abstract: BACKGROUND: The effectiveness of intra-articular platelet-rich plasma ( @entity7676 ) injections has been evaluated in knee chondroplasty and @entity571 ( @entity571 ); however, little evidence of its efficacy in @entity570 exists. PURPOSE: To compare the therapeutic efficacy of autologous @entity7676 , @entity7245 ( @entity7245 ), or a combination of both ( @entity7676 + @entity7245 ) in @entity570 . STUDY DESIGN: Randomized controlled trial; Level of evidence, 1. METHODS: @entity1 aged between 18 and 65 years who were treated with outpatient surgery and who had @entity570 and @entity158 intensity at baseline of >20 on a 100-mm visual analog scale (VAS) were recruited for this study. Exclusion criteria were extensive surgery; presence of @entity65 . The primary outcome measure was a change in @entity158 intensity as assessed by the VAS at 2, 6, and 12 months after treatment. Secondary outcome measures were the Harris Hip Score, Western Ontario and McMaster Universities @entity571 Index (WOMAC), and concentration of growth factors in @entity7676 and their correlation with clinical outcomes. Clinical outcomes were evaluated by assessors and collectors blinded to the type of treatment administered. RESULTS: A total of 111 @entity1 were randomly assigned to 3 groups and received 3 weekly injections of either @entity7676 (44 @entity1 ), @entity7676 + @entity7245 (31 @entity1 ), or @entity7245 (36 @entity1 ). At all follow-ups, the @entity7676 group had the lowest VAS scores. In particular, at 6-month follow-up, the mean VAS score was 21 (95% CI, 15-28) in the @entity7676 group, 35 (95% CI, 26-45) in the @entity7676 + @entity7245 group, and 44 (95% CI, 36-52) in the @entity7245 group (P < .0005 [ @entity7676 vs @entity7245 ] and P = .007 [ @entity7676 vs @entity7676 + @entity7245 ]; F = 0.663). The WOMAC score of the @entity7676 group was significantly better at 2-month follow-up (mean, 73; 95% CI, 68-78) and 6-month follow-up (mean, 72; 95% CI, 67-76) but not at 12-month follow-up. A significant, "moderate" correlation was found between @entity688 and variations of the VAS score (r = 0.392; P = .040). Significant improvements were achieved in @entity158 and ameliorating quality of life and functional recovery. CONCLUSION: Results indicated that intra-articular @entity7676 injections offer a significant clinical improvement in @entity1 with @entity570 without relevant side effects. The benefit was significantly more stable up to 12 months as compared with the other tested treatments. The addition of @entity7676 + @entity7245 did not lead to a significant improvement in @entity158 symptoms.

title: Ultrasound-Guided Injection of Platelet-Rich Plasma and Hyaluronic Acid, Separately and in Combination, for XXXX : A Randomized Controlled Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity7245 :: ('MESH:D000592', 'Disease') :: ['hyaluronic acid', 'HA']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA', 'Osteoarthritis']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'reducing pain']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['excessive deformities; or rheumatic, infective, cardiovascular, or immune system disorders']

answer: @entity570 :: (MESH:D015207,Disease) :: ['Hip Osteoarthritis']


abstract: BACKGROUND: Lesogaberan ( @entity29226 ) is a novel reflux inhibitor developed as an add-on treatment to proton pump inhibitors (PPIs) for symptom relief in @entity1 with @entity354 who have a partial response to PPI therapy. OBJECTIVE: The aim of this study was to evaluate the pharmacokinetic profile of lesogaberan in healthy subjects after single oral and intravenous administration of @entity3209 -labeled lesogaberan and non- @entity3209 -labeled lesogaberan. STUDY DESIGN: This was an open-label, single-center, randomized, two-way crossover, phase I study. @entity1 : Ten healthy male subjects took part in the study. INTERVENTION: Volunteers were randomized to receive a single dose of either orally dosed (100   mg) or intravenously infused (20   mg) non- @entity3209 -labeled lesogaberan, and then orally (100   mg) or intravenously (20   mg) administered @entity3209 -labeled lesogaberan in a crossover design. Treatment periods were separated by a washout period of at least 7 days. MAIN OUTCOME MEASURES: Analyses of the rate and route of excretion, dose recovery, area under the plasma concentration versus time curve (AUC), AUC to the last quantifiable concentration, maximal plasma concentration (C(max)), time to C(max), the apparent elimination half-life, bioavailability, total clearance, renal clearance, fraction of the bioavailable dose excreted unchanged in the urine, cumulative amount of drug excreted unchanged in urine, and the apparent volume of distribution at steady state of lesogaberan. RESULTS: @entity29226 was rapidly and extensively absorbed from the gastrointestinal tract and C(max) was achieved within 1-2 hours of oral dosing. The terminal half-life of lesogaberan was between 11 and 13 hours. Renal clearance accounted for approximately 22% of total body clearance. Based on the recovery of administered radioactivity, approximately 84% of the dose was excreted into the urine either as the parent compound or as water-soluble metabolite(s). There were no safety concerns raised during the study. CONCLUSION: Orally administered @entity29226 is rapidly absorbed with high bioavailability and the majority of the dose is excreted by the kidneys either as the parent compound or as metabolites. The major elimination pathway for lesogaberan in @entity1 is metabolism.

title: Pharmacokinetic profile of lesogaberan ( XXXX ) in healthy subjects: a novel GABA(B)-receptor agonist reflux inhibitor.

entities_list: @entity29226 :: ('MESH:C545087', 'Chemical') :: ['lesogaberan', 'Lesogaberan', 'AZD3355']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'man', 'PARTICIPANTS']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease']

answer: @entity29226 :: (MESH:C545087,Chemical) :: ['AZD3355']


abstract: BACKGROUND: A plethora of studies have described repair of @entity85 in @entity1 , but only few reports have described this repair in adults. The purpose of this study was to review our 30-year experience with surgical repair of @entity85 in adults. METHODS: A retrospective review of all adult @entity1 (> 16 years old) who underwent repair of congenital @entity85 from 1971 through 2001. RESULTS: There were 77 @entity1 , 64 @entity1 and 13 @entity1 . Sixty-eight @entity1 underwent surgery for @entity1408 and 9 for pectus carinatum; median age was 22 years old (range, 16 to 68 years old). Indication for repair was medical concerns in all @entity1 . Preoperative symptoms were @entity1353 on exertion in 43 @entity1 , @entity1353 at rest in 22 @entity1 , @entity662 in 8 @entity1 , and palpitations in 8 @entity1 . Preoperative electrocardiogram findings included @entity714 in 9 @entity1 , sinus @entity1168 in 8 @entity1 , @entity4032 in 6 @entity1 , and right @entity384 in 5 @entity1 . Patterns of the pectus defect were symmetric and localized in 29 @entity1 , symmetric and diffuse in 21, asymmetric and localized in 18, and asymmetric and diffuse in 9 @entity1 . Intraoperative classifications were severe in 38 @entity1 , moderate in 33 @entity1 , and mild in 6 @entity1 . There were no operative deaths. Complications occurred in 11 @entity1 (14.3%). Mean hospital stay was 4 days (range, 2 to 8 days). Mean follow-up was 12 +/- 7 years (range, 4 months old to 24 years old); 1 @entity1 (1.3%) required reoperation for recurrent @entity1408 . @entity1 satisfaction and relief of medical symptoms was excellent in 70 @entity1 (90.9%), good in 6 @entity1 , and fair in 1 @entity1 . CONCLUSIONS: Repair of @entity154 of the sternum in adults can be performed safely with low morbidity and no mortality. Long-term results are excellent with requirement for reoperation rare.

title: Thirty-year experience with repair of XXXX in adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'patients', 'patient', 'Patient', 'men']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital defects']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath', 'dyspnea']

entities_list: @entity714 :: ('MESH:D002037', 'Disease') :: ['right bundle branch block']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['atrial dilatation']

entities_list: @entity4032 :: ('MESH:D059446', 'Disease') :: ['left atrial enlargement']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['pectus deformities']

entities_list: @entity1408 :: ('MESH:D005660', 'Disease') :: ['pectus excavatum']

answer: @entity85 :: (MESH:D009140,Disease) :: ['pectus deformities']


abstract: OBJECTIVES: Although both radiation therapy and chemotherapy are frequently used to treat @entity788 ( @entity788 ) @entity1 , the role of radiation therapy remains controversial with data evaluating its efficacy mostly derived from small randomized trials. In this study, we evaluate the survival benefit of radiation therapy using SEER dataset in @entity1 with @entity788 . MATERIALS AND METHODS: The SEER Registry dataset from 2004 to 2011 was queried to identify @entity788 (TNM stage III) @entity1 . @entity1 with survival <2 months, unknown radiation status, or who received postoperative radiation were excluded. Multivariate analyses of prognostic factors related to survival were performed using a Cox proportional hazard-regression model. Propensity scores were estimated using probit regression. RESULTS: Our search identified 4460 @entity1 ; 59% who received radiation and 41% who did not. Radiation group @entity1 were younger (below 65 y old: 49% vs. 38%), had smaller @entity5 size (largest dimension <4.5 cm: 80% vs. 75%), less lymph node involvement (33% vs. 36%), and lower rate of surgical resection (4% vs. 9%). @entity1 who received radiation therapy had better survival (HR=0.773; 95% CI, 0.687-0.782). The 12-month overall survival in the radiation group and nonradiation group was 43% versus 29%, respectively (P<0.001). On multivariate analyses, radiation was independently associated with improved outcomes. The survival benefit with radiation was observed in propensity score-matched cohort. CONCLUSIONS: Radiation therapy was associated with improved survival. Prospective randomized trials are needed to confirm these findings. The optimal schedule and radiation type remain undetermined.

title: Use of Radiation Therapy in Locally Advanced XXXX Improves Survival: A SEER Database Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['locally advanced pancreatic cancer', 'LAPC']

answer: @entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']


abstract: UNASSIGNED: Thalamic @entity548 are associated with a variety of @entity73 , and it is well known that such cognitive changes constitute a limiting factor of recovery of the activities of daily living (ADL). The relationship between @entity73 and @entity1410 is unclear. In this study, we investigated the relationship between @entity2026 /neglect and @entity1410 volume, @entity1410 type, and the ADL. One hundred fifteen @entity1 with @entity548 (70 @entity1 and 45 @entity1 ) were studied. Their mean age was 68.9      10.3  years, and @entity1 with both @entity75 were included. We calculated @entity1410 volume and examined the presence or absence of @entity2026 /neglect and the relationships between these dysfunctions and @entity1410 volume, @entity1410 type, and the ADL. Fifty-nine @entity1 were found to have @entity2026 and 35 were found to have neglect. Although there was no relationship between @entity1410 type and @entity73 , @entity1410 volume showed a correlation with the severity of @entity73 . The ADL score and ratio of @entity1 discharge for @entity1 with @entity2026 /neglect were lower than those for @entity1 without @entity2026 /neglect. We observed a correlation between the @entity1410 volume in @entity548 and @entity73 . @entity2026 /neglect is found frequently in @entity1 with @entity548 and may influence the ADL.

title: XXXX and unilateral spatial neglect due to @entity548 : clinical correlations and outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['thalamic hemorrhage', 'acute thalamic hemorrhage', 'hemorrhages']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['left and right lesions']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunctions', 'cognitive dysfunction']

entities_list: @entity2026 :: ('MESH:D001037', 'Disease') :: ['aphasia', 'Aphasia']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas', 'hematoma']

answer: @entity2026 :: (MESH:D001037,Disease) :: ['Aphasia']


abstract: UNASSIGNED: Thalamic @entity548 are associated with a variety of @entity73 , and it is well known that such cognitive changes constitute a limiting factor of recovery of the activities of daily living (ADL). The relationship between @entity73 and @entity1410 is unclear. In this study, we investigated the relationship between @entity2026 /neglect and @entity1410 volume, @entity1410 type, and the ADL. One hundred fifteen @entity1 with @entity548 (70 @entity1 and 45 @entity1 ) were studied. Their mean age was 68.9      10.3  years, and @entity1 with both @entity75 were included. We calculated @entity1410 volume and examined the presence or absence of @entity2026 /neglect and the relationships between these dysfunctions and @entity1410 volume, @entity1410 type, and the ADL. Fifty-nine @entity1 were found to have @entity2026 and 35 were found to have neglect. Although there was no relationship between @entity1410 type and @entity73 , @entity1410 volume showed a correlation with the severity of @entity73 . The ADL score and ratio of @entity1 discharge for @entity1 with @entity2026 /neglect were lower than those for @entity1 without @entity2026 /neglect. We observed a correlation between the @entity1410 volume in @entity548 and @entity73 . @entity2026 /neglect is found frequently in @entity1 with @entity548 and may influence the ADL.

title: @entity2026 and unilateral spatial neglect due to XXXX : clinical correlations and outcomes.

answer: @entity548 :: (MESH:D006470,Disease) :: ['acute thalamic hemorrhage']


abstract: OBJECTIVES: The association between @entity82 and @entity194 (IFTA) and the clinical outcomes in @entity2316 ( @entity2316 ) remains unclear. This study is to evaluate the clinical predictors and renal prognosis of IFTA score in @entity1 with @entity2316 . METHODS: 52 cases with @entity2316 with renal biopsy were divided into three groups according to IFTA score. The   (2) test or Fisher's exact test, Mann-Whitney U-test, Kruskal-Wallis H-test and Spearman's correlation analysis were used in this subject. Ordinal regression mode was utilized to evaluate which clinical factors might be the predictors of IFTA score. RESULTS: Compared to IFTA score 1 group, the @entity1 in score 3 were younger and have greatly lower level of @entity470 and hemoglobin and higher serum @entity1011 (p<0.01). A close relationship between the clinical findings and IFTA was observed, such as IFTA with @entity470 (r=-0.58, P<0.01), @entity412 (r=-0.29, P=0.04), Hb (r=-0.38, P<0.01), systolic blood pressure (r=0.29, P=0.04) and urinary protein level (r=0.46, P<0.01); in addition, @entity470 (OR 0.31 (95%Cl -1.883 to -0.485) p=0.001) showed statistical significance with IFTA. The 5-year renal survival rate was estimated as 100% in IFTA score 0, 88.9% in score 1, 76.9% in score 2, and 20.0% in score 3. Furthermore, greatly lower level of @entity470 , and higher serum @entity1011 and BUN in the glomerular class IV were seen (p<0.01 vs class II), with positive correlation with IFTA (r=0.51, P<0.01). CONCLUSION: The renal pathologic diagnosis in IFTA score was a good predictor for renal prognosis in @entity3918 . @entity470 might be a predictor of IFTA in @entity1 with @entity2316 .

title: Validation of the XXXX and @entity194 on the new pathological classification in @entity1 with @entity2316 : A single-center study in China.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy', 'DN']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['tubular atrophy']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity82 :: (MESH:D005355,Disease) :: ['interstitial fibrosis']


abstract: OBJECTIVES: The association between @entity82 and @entity194 (IFTA) and the clinical outcomes in @entity2316 ( @entity2316 ) remains unclear. This study is to evaluate the clinical predictors and renal prognosis of IFTA score in @entity1 with @entity2316 . METHODS: 52 cases with @entity2316 with renal biopsy were divided into three groups according to IFTA score. The   (2) test or Fisher's exact test, Mann-Whitney U-test, Kruskal-Wallis H-test and Spearman's correlation analysis were used in this subject. Ordinal regression mode was utilized to evaluate which clinical factors might be the predictors of IFTA score. RESULTS: Compared to IFTA score 1 group, the @entity1 in score 3 were younger and have greatly lower level of @entity470 and hemoglobin and higher serum @entity1011 (p<0.01). A close relationship between the clinical findings and IFTA was observed, such as IFTA with @entity470 (r=-0.58, P<0.01), @entity412 (r=-0.29, P=0.04), Hb (r=-0.38, P<0.01), systolic blood pressure (r=0.29, P=0.04) and urinary protein level (r=0.46, P<0.01); in addition, @entity470 (OR 0.31 (95%Cl -1.883 to -0.485) p=0.001) showed statistical significance with IFTA. The 5-year renal survival rate was estimated as 100% in IFTA score 0, 88.9% in score 1, 76.9% in score 2, and 20.0% in score 3. Furthermore, greatly lower level of @entity470 , and higher serum @entity1011 and BUN in the glomerular class IV were seen (p<0.01 vs class II), with positive correlation with IFTA (r=0.51, P<0.01). CONCLUSION: The renal pathologic diagnosis in IFTA score was a good predictor for renal prognosis in @entity3918 . @entity470 might be a predictor of IFTA in @entity1 with @entity2316 .

title: Validation of the @entity82 and XXXX on the new pathological classification in @entity1 with @entity2316 : A single-center study in China.

answer: @entity194 :: (MESH:D001284,Disease) :: ['tubular atrophy']


abstract: OBJECTIVES: The association between @entity82 and @entity194 (IFTA) and the clinical outcomes in @entity2316 ( @entity2316 ) remains unclear. This study is to evaluate the clinical predictors and renal prognosis of IFTA score in @entity1 with @entity2316 . METHODS: 52 cases with @entity2316 with renal biopsy were divided into three groups according to IFTA score. The   (2) test or Fisher's exact test, Mann-Whitney U-test, Kruskal-Wallis H-test and Spearman's correlation analysis were used in this subject. Ordinal regression mode was utilized to evaluate which clinical factors might be the predictors of IFTA score. RESULTS: Compared to IFTA score 1 group, the @entity1 in score 3 were younger and have greatly lower level of @entity470 and hemoglobin and higher serum @entity1011 (p<0.01). A close relationship between the clinical findings and IFTA was observed, such as IFTA with @entity470 (r=-0.58, P<0.01), @entity412 (r=-0.29, P=0.04), Hb (r=-0.38, P<0.01), systolic blood pressure (r=0.29, P=0.04) and urinary protein level (r=0.46, P<0.01); in addition, @entity470 (OR 0.31 (95%Cl -1.883 to -0.485) p=0.001) showed statistical significance with IFTA. The 5-year renal survival rate was estimated as 100% in IFTA score 0, 88.9% in score 1, 76.9% in score 2, and 20.0% in score 3. Furthermore, greatly lower level of @entity470 , and higher serum @entity1011 and BUN in the glomerular class IV were seen (p<0.01 vs class II), with positive correlation with IFTA (r=0.51, P<0.01). CONCLUSION: The renal pathologic diagnosis in IFTA score was a good predictor for renal prognosis in @entity3918 . @entity470 might be a predictor of IFTA in @entity1 with @entity2316 .

title: Validation of the @entity82 and @entity194 on the new pathological classification in @entity1 with XXXX : A single-center study in China.

answer: @entity2316 :: (MESH:D003928,Disease) :: ['diabetic nephropathy']


abstract: OBJECTIVES: The association between @entity82 and @entity194 (IFTA) and the clinical outcomes in @entity2316 ( @entity2316 ) remains unclear. This study is to evaluate the clinical predictors and renal prognosis of IFTA score in @entity1 with @entity2316 . METHODS: 52 cases with @entity2316 with renal biopsy were divided into three groups according to IFTA score. The   (2) test or Fisher's exact test, Mann-Whitney U-test, Kruskal-Wallis H-test and Spearman's correlation analysis were used in this subject. Ordinal regression mode was utilized to evaluate which clinical factors might be the predictors of IFTA score. RESULTS: Compared to IFTA score 1 group, the @entity1 in score 3 were younger and have greatly lower level of @entity470 and hemoglobin and higher serum @entity1011 (p<0.01). A close relationship between the clinical findings and IFTA was observed, such as IFTA with @entity470 (r=-0.58, P<0.01), @entity412 (r=-0.29, P=0.04), Hb (r=-0.38, P<0.01), systolic blood pressure (r=0.29, P=0.04) and urinary protein level (r=0.46, P<0.01); in addition, @entity470 (OR 0.31 (95%Cl -1.883 to -0.485) p=0.001) showed statistical significance with IFTA. The 5-year renal survival rate was estimated as 100% in IFTA score 0, 88.9% in score 1, 76.9% in score 2, and 20.0% in score 3. Furthermore, greatly lower level of @entity470 , and higher serum @entity1011 and BUN in the glomerular class IV were seen (p<0.01 vs class II), with positive correlation with IFTA (r=0.51, P<0.01). CONCLUSION: The renal pathologic diagnosis in IFTA score was a good predictor for renal prognosis in @entity3918 . @entity470 might be a predictor of IFTA in @entity1 with @entity2316 .

title: Validation of the @entity82 and @entity194 on the new pathological classification in XXXX with @entity2316 : A single-center study in China.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: To evaluate long-term safety and efficacy of iStent trabecular micro-bypass stent implantation during @entity231 surgery in @entity1 with primary open-angle, @entity9998 , @entity2790 , or secondary or post-traumatic @entity726 . SETTING: AaM Augenklinik am Marienplatz, Munich, Germany. DESIGN: Prospective, open-label, non-randomized study. METHODS: Preoperative and postoperative evaluations included intra-ocular pressure (IOP), @entity551 medication use, cup/disc ratio, corrected-distance visual acuity (CDVA), complications, and adverse events. RESULTS: A single trabecular micro-bypass stent was implanted through the same temporal, limbal incision used for @entity231 surgery via phacoemulsification in a consecutive series of 62 eyes of 43 @entity1 . To date, a total of 41 eyes have been followed for 3  years postoperatively, whereas long-term postoperative follow-up on the remaining @entity1 is ongoing. Mean preoperative IOP was 24.1      6.9 mm Hg on a mean of 1.8 medications (  0.9). Analyses of eyes with no secondary surgical intervention showed mean IOP reduction to 14.8      4.2 mm Hg at 12  months (n  =  61), 14.5      2.2 mm Hg at 24  months (n  =  42), and 14.9      2.3 mm Hg at 36  months (n  =  39). Medications were eliminated in 74% of eyes at 36  months. Five eyes, 4 with previous @entity726 surgeries and 1 with @entity9998 , required additional @entity726 surgery after stent implantation. No intra-operative or postoperative complications typically seen with conventional @entity726 surgeries occurred after stent implantation. At 36  months, CDVA was 20/40 or better in 38 eyes (93%). CONCLUSION: Trabecular micro-bypass stent implantation during @entity231 surgery was safe and effective in @entity1 with @entity2790 or @entity726 as measured by a sustained reduction in IOP and medication use and an excellent safety profile through 3  years after surgery. FINANCIAL DISCLOSURES: Dr. Neuhann has no financial or proprietary interest in any material or method mentioned. Glaukos Corp. provided editorial assistance in the preparation of the manuscript.

title: Trabecular micro-bypass stent implantation during small-incision @entity231 surgery for open-angle glaucoma or XXXX : Long-term results.

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity9998 :: ('MESH:D017889', 'Disease') :: ['pseudo-exfoliation glaucoma', 'pseudo-exfoliation syndrome']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity2790 :: ('MESH:D009798', 'Disease') :: ['ocular hypertension']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['topical ocular hypotensive']

answer: @entity2790 :: (MESH:D009798,Disease) :: ['ocular hypertension']


abstract: PURPOSE: To evaluate long-term safety and efficacy of iStent trabecular micro-bypass stent implantation during @entity231 surgery in @entity1 with primary open-angle, @entity9998 , @entity2790 , or secondary or post-traumatic @entity726 . SETTING: AaM Augenklinik am Marienplatz, Munich, Germany. DESIGN: Prospective, open-label, non-randomized study. METHODS: Preoperative and postoperative evaluations included intra-ocular pressure (IOP), @entity551 medication use, cup/disc ratio, corrected-distance visual acuity (CDVA), complications, and adverse events. RESULTS: A single trabecular micro-bypass stent was implanted through the same temporal, limbal incision used for @entity231 surgery via phacoemulsification in a consecutive series of 62 eyes of 43 @entity1 . To date, a total of 41 eyes have been followed for 3  years postoperatively, whereas long-term postoperative follow-up on the remaining @entity1 is ongoing. Mean preoperative IOP was 24.1      6.9 mm Hg on a mean of 1.8 medications (  0.9). Analyses of eyes with no secondary surgical intervention showed mean IOP reduction to 14.8      4.2 mm Hg at 12  months (n  =  61), 14.5      2.2 mm Hg at 24  months (n  =  42), and 14.9      2.3 mm Hg at 36  months (n  =  39). Medications were eliminated in 74% of eyes at 36  months. Five eyes, 4 with previous @entity726 surgeries and 1 with @entity9998 , required additional @entity726 surgery after stent implantation. No intra-operative or postoperative complications typically seen with conventional @entity726 surgeries occurred after stent implantation. At 36  months, CDVA was 20/40 or better in 38 eyes (93%). CONCLUSION: Trabecular micro-bypass stent implantation during @entity231 surgery was safe and effective in @entity1 with @entity2790 or @entity726 as measured by a sustained reduction in IOP and medication use and an excellent safety profile through 3  years after surgery. FINANCIAL DISCLOSURES: Dr. Neuhann has no financial or proprietary interest in any material or method mentioned. Glaukos Corp. provided editorial assistance in the preparation of the manuscript.

title: Trabecular micro-bypass stent implantation during small-incision XXXX surgery for open-angle glaucoma or @entity2790 : Long-term results.

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']


abstract: CONTEXT: The terrorist attacks on Israeli society have been ongoing since September 2000. However, few studies have examined the impact of @entity13390 on nationally representative population samples, and no study has examined the psychological impact of ongoing @entity13390 in Israel. OBJECTIVES: To determine the level of exposure to terrorist attacks and the prevalence of traumatic stress-related (TSR) symptoms, symptoms of @entity1005 ( @entity1005 ), and sense of safety after 19 months of @entity13390 in Israel, and to identify correlates of the psychological sequelae and the modes of coping with the @entity13390 . DESIGN, SETTING, AND @entity1 : Telephone survey conducted April-May 2002, using a strata sampling method, of 902 eligible households and a representative sample of 742 Israeli residents older than 18 years (82% contact rate) and a final participation of 512 (57%). MAIN OUTCOME MEASURES: Number of TSR symptoms, rates of those with symptom criteria for @entity1005 and @entity14469 assessed by the Stanford Acute Stress Reaction Questionnaire, self-reported feelings of @entity308 , optimism, sense of safety, help-seeking, and modes of coping. RESULTS: Of 512 survey @entity1 , 84 (16.4%) had been directly exposed to a terrorist attack and 191 (37.3%) had a family member or friend who had been exposed. Of 510 @entity1 who responded to questions about TSR symptoms, 391 (76.7%) had at least 1 TSR symptom (mean, 4.0 [SD, 4.5]; range, 0-23; mean intensity, 0.8; range, 0-4). Symptom criteria for @entity1005 were met by 48 @entity1 (9.4%) and criteria for @entity14469 , by 1 @entity1 ; 299 (58.6%) reported feeling @entity308 . The majority of respondents expressed optimism about their personal future (421/512 [82.2%]) and the future of Israel (307/509 [66.8%]), and expressed self-efficacy with regard to their ability to function in a terrorist attack (322/431 [74.6%]). Most expressed a low sense of safety with respect to themselves (307/509 [60.4%]) and their relatives (345/507 [67.9%]). Few reported a need for professional help (27/506 [5.3%]). Female sex, sense of safety, and use of tranquilizers, @entity167 , and cigarettes to cope were associated with TSR symptoms and symptom criteria for @entity1005 ; level of exposure and objective risk were not. The most prevalent coping mechanisms were active information search about loved ones and social support. CONCLUSIONS: Considering the nature and length of the Israeli traumatic experience, the psychological impact may be considered moderate. Although the survey @entity1 showed distress and lowered sense of safety, they did not develop high levels of @entity146 , which may be related to a habituation process and to coping mechanisms.

title: Exposure to XXXX , stress-related mental health symptoms, and @entity146 among a nationally representative sample in Israel.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'PARTICIPANTS']

entities_list: @entity14469 :: ('MESH:D040701', 'Disease') :: ['acute stress disorder']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric distress']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['posttraumatic stress disorder', 'PTSD']

answer: @entity13390 :: (MESH:D020184,Disease) :: ['terrorism']


abstract: CONTEXT: The terrorist attacks on Israeli society have been ongoing since September 2000. However, few studies have examined the impact of @entity13390 on nationally representative population samples, and no study has examined the psychological impact of ongoing @entity13390 in Israel. OBJECTIVES: To determine the level of exposure to terrorist attacks and the prevalence of traumatic stress-related (TSR) symptoms, symptoms of @entity1005 ( @entity1005 ), and sense of safety after 19 months of @entity13390 in Israel, and to identify correlates of the psychological sequelae and the modes of coping with the @entity13390 . DESIGN, SETTING, AND @entity1 : Telephone survey conducted April-May 2002, using a strata sampling method, of 902 eligible households and a representative sample of 742 Israeli residents older than 18 years (82% contact rate) and a final participation of 512 (57%). MAIN OUTCOME MEASURES: Number of TSR symptoms, rates of those with symptom criteria for @entity1005 and @entity14469 assessed by the Stanford Acute Stress Reaction Questionnaire, self-reported feelings of @entity308 , optimism, sense of safety, help-seeking, and modes of coping. RESULTS: Of 512 survey @entity1 , 84 (16.4%) had been directly exposed to a terrorist attack and 191 (37.3%) had a family member or friend who had been exposed. Of 510 @entity1 who responded to questions about TSR symptoms, 391 (76.7%) had at least 1 TSR symptom (mean, 4.0 [SD, 4.5]; range, 0-23; mean intensity, 0.8; range, 0-4). Symptom criteria for @entity1005 were met by 48 @entity1 (9.4%) and criteria for @entity14469 , by 1 @entity1 ; 299 (58.6%) reported feeling @entity308 . The majority of respondents expressed optimism about their personal future (421/512 [82.2%]) and the future of Israel (307/509 [66.8%]), and expressed self-efficacy with regard to their ability to function in a terrorist attack (322/431 [74.6%]). Most expressed a low sense of safety with respect to themselves (307/509 [60.4%]) and their relatives (345/507 [67.9%]). Few reported a need for professional help (27/506 [5.3%]). Female sex, sense of safety, and use of tranquilizers, @entity167 , and cigarettes to cope were associated with TSR symptoms and symptom criteria for @entity1005 ; level of exposure and objective risk were not. The most prevalent coping mechanisms were active information search about loved ones and social support. CONCLUSIONS: Considering the nature and length of the Israeli traumatic experience, the psychological impact may be considered moderate. Although the survey @entity1 showed distress and lowered sense of safety, they did not develop high levels of @entity146 , which may be related to a habituation process and to coping mechanisms.

title: Exposure to @entity13390 , stress-related mental health symptoms, and XXXX among a nationally representative sample in Israel.

answer: @entity146 :: (MESH:D001523,Disease) :: ['coping behaviors']


abstract: BACKGROUND: On-going @entity311 transmission is increasingly mediated by outdoor-biting vectors, especially where indoor insecticidal interventions such as long-lasting insecticide treated nets (LLINs) are widespread. Often, the vectors are also physiologically resistant to insecticides, presenting major obstacles for elimination. We tested a combination of electrocuting grids with synthetic odours as an alternative killing mechanism against outdoor-biting mosquitoes. METHODS: An odour-baited device, the Mosquito Landing Box (MLB), was improved by fitting it with low-cost electrocuting grids to instantly kill mosquitoes attracted to the odour lure, and automated photo switch to activate attractant-dispensing and mosquito-killing systems between dusk and dawn. MLBs fitted with one, two or three electrocuting grids were compared outdoors in a @entity311 endemic village in Tanzania, where vectors had lost susceptibility to @entity312 . MLBs with three grids were also tested in a large semi-field cage (9.6*9.6*4.5m), to assess effects on biting-densities of laboratory-reared Anopheles arabiensis on volunteers sitting near MLBs. RESULTS: Significantly more mosquitoes were killed when MLBs had two or three grids, than one grid in wet and dry seasons (P<0.05). The MLBs were highly efficient against Mansonia species and @entity311 vector, An. arabiensis. Of all mosquitoes, 99% were non-blood fed, suggesting host-seeking status. In the semi-field, the MLBs reduced mean number of @entity311 mosquitoes attempting to bite @entity1 fourfold. CONCLUSION: The improved odour-baited MLBs effectively kill outdoor-biting @entity311 vector mosquitoes that are behaviourally and physiologically resistant to insecticidal interventions e.g. LLINs. The MLBs reduce @entity1 -biting vector densities even when used close to @entity1 , and are insecticide-free, hence potentially antiresistance. The devices could either be used as surveillance tools or complementary mosquito control interventions to accelerate @entity311 elimination where outdoor transmission is significant.

title: Combining Synthetic XXXX Odours and Low-Cost Electrocuting Grids to Attract and Kill Outdoor-Biting Mosquitoes: Field and Semi-Field Evaluation of an Improved Mosquito Landing Box.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity312 :: ('MESH:D011722', 'Chemical') :: ['pyrethroids']

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: CONTEXT: Studies suggested a potential value of preablative stimulated Tg (ps-Tg) on predicting the recurrent and persistent diseases of @entity259 ( @entity259 ), whereas its correlations with therapeutic response remain uncertain. OBJECTIVE: To establish the correlation between ps-Tg and therapeutic response proposed in 2015 American Thyroid Association (ATA) guidelines, and calculate a cut-off ps-Tg threshold for predicting a poor response. DESIGN/SETTING: @entity1 who underwent total thyroidectomy and radioactive @entity1496 (RAI) therapy in a University hospital participated in this retrospective study. @entity1 : Totally, 452 @entity259 @entity1 were followed for a median of 38 months and were divided into three groups in terms of ps-Tg level: Group1:<1ng/ml (n=82), Group2: 1-10ng/ml (n=173), Group3:>= 10ng/ml (n=197). MAIN OUTCOME MEASURE: Clinical outcomes were assessed based on response to therapy re-staging system, dividing response into excellent (ER), indeterminate (IDR), biomedical incomplete (BIR), and structural incomplete (SIR). RESULTS: Therapeutic responses could be obviously distinguished by different ps-Tg strata. SIR was identified in none of Group 1, 1.73% of Group 2, and 42.74% of Group 3, respectively ((2)=123.037, p<0.001). A cut-off value of ps-Tg at 26.75 ng/ml was obtained by receiver operating characteristic (ROC) curve for differentiating SIR from either ER, IDR, or BIR. The area under curve (AUC) was 0.947 and negative predictive value (NPV) was 96.99%. Ps-Tg was an independent predictive variable of SIR (OR: 42.312, p<0.001). CONCLUSIONS: Ps-Tg has a great performance in predicting therapeutic response and providing incremental value for decision making of RAI therapy, especially for @entity1 with high ps-Tg level.

title: Preablative stimulated thyroglobulin correlates to new therapy response system in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['DTC', 'differentiated thyroid cancer']

answer: @entity259 :: (MESH:D013964,Disease) :: ['differentiated thyroid cancer']


abstract: The acute @entity137 of @entity72788 (CMT) was studied in @entity35 . CMT was found to produce @entity410 and @entity3126 . The ED50s for @entity410 were 32 mg/kg (95% C.I. 24-42 mg/kg) p.o. and 20 mg/kg (95% C.I. 15-26 mg/kg) i.p. The LD50s for p.o. and i.p. administration were 22 mg/kg (95% C.I. 19-26 mg/kg) and 14 mg/kg (95% C.I. 10-20 mg/kg), respectively. Approximately 13-16% of the administered dose was recovered in the urine from 0 to 48 h post-dosing. The majority of this material was present as an organometallic form of @entity921 other than CMT. @entity109 pretreatment prevented the @entity410 and @entity358 produced by a 50 mg/kg i.p. dose of CMT. @entity35 pretreated with CMT (5 mg/kg, i.p.) for 3 days exhibited @entity410 but no deaths after treatment with a 34 mg/kg p.o. dose of CMT. These results suggest that CMT does not require metabolic activation to produce toxic effects, and that prior exposure to CMT produces tolerance.

title: The acute XXXX of @entity72788 in the @entity35 .

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsion', 'convulsions']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity72788 :: ('MESH:C044679', 'Chemical') :: ['cyclopentadienyl manganese tricarbonyl']

entities_list: @entity921 :: ('MESH:D008345', 'Chemical') :: ['manganese']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['pulmonary edema']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary damage']

entities_list: @entity109 :: ('MESH:D010634', 'Chemical') :: ['Phenobarbital']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: The acute @entity137 of @entity72788 (CMT) was studied in @entity35 . CMT was found to produce @entity410 and @entity3126 . The ED50s for @entity410 were 32 mg/kg (95% C.I. 24-42 mg/kg) p.o. and 20 mg/kg (95% C.I. 15-26 mg/kg) i.p. The LD50s for p.o. and i.p. administration were 22 mg/kg (95% C.I. 19-26 mg/kg) and 14 mg/kg (95% C.I. 10-20 mg/kg), respectively. Approximately 13-16% of the administered dose was recovered in the urine from 0 to 48 h post-dosing. The majority of this material was present as an organometallic form of @entity921 other than CMT. @entity109 pretreatment prevented the @entity410 and @entity358 produced by a 50 mg/kg i.p. dose of CMT. @entity35 pretreated with CMT (5 mg/kg, i.p.) for 3 days exhibited @entity410 but no deaths after treatment with a 34 mg/kg p.o. dose of CMT. These results suggest that CMT does not require metabolic activation to produce toxic effects, and that prior exposure to CMT produces tolerance.

title: The acute @entity137 of XXXX in the @entity35 .

answer: @entity72788 :: (MESH:C044679,Chemical) :: ['cyclopentadienyl manganese tricarbonyl']


abstract: The acute @entity137 of @entity72788 (CMT) was studied in @entity35 . CMT was found to produce @entity410 and @entity3126 . The ED50s for @entity410 were 32 mg/kg (95% C.I. 24-42 mg/kg) p.o. and 20 mg/kg (95% C.I. 15-26 mg/kg) i.p. The LD50s for p.o. and i.p. administration were 22 mg/kg (95% C.I. 19-26 mg/kg) and 14 mg/kg (95% C.I. 10-20 mg/kg), respectively. Approximately 13-16% of the administered dose was recovered in the urine from 0 to 48 h post-dosing. The majority of this material was present as an organometallic form of @entity921 other than CMT. @entity109 pretreatment prevented the @entity410 and @entity358 produced by a 50 mg/kg i.p. dose of CMT. @entity35 pretreated with CMT (5 mg/kg, i.p.) for 3 days exhibited @entity410 but no deaths after treatment with a 34 mg/kg p.o. dose of CMT. These results suggest that CMT does not require metabolic activation to produce toxic effects, and that prior exposure to CMT produces tolerance.

title: The acute @entity137 of @entity72788 in the XXXX .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: Exaggerated postprandial @entity412 concentration is believed to be atherogenic, and to influence the risk of @entity715 . Both elevated @entity2289 ( @entity2289 ) and increased factor VII coagulant activity (FVIIc) are potential important contributors to the increased risk of @entity65 in @entity164 2 @entity6 . AIM: We aimed to investigate the effect of adding four different protein types (i.e. casein, whey, cod, and gluten) to a fat-rich meal on postprandial responses of @entity2289 and FVIIc in @entity164 2 @entity6 @entity1 . METHODS: Twelve @entity164 2 @entity6 @entity1 ingested four isocaloric test meals in random order. The test meals contained 100 g of butter and 45 g of @entity1735 in combination with 45 g of casein (Cas-meal), whey (Whe-meal), cod (Cod-meal), or gluten ( @entity367 -meal), respectively. Plasma concentrations of @entity2289 and FVIIc were measured before meal, and at regular intervals for 8-h postprandially. RESULTS: The postprandial @entity2289 concentration decreased significantly by 49% to 56% in response to the four test meals. There were no significant differences between the outcomes from the four test-meals. The FVIIc levels decreased by 8% to 11% after the meals. Again, we observed no significant differences in outcomes between the four protein-enriched meals. CONCLUSIONS: The four proteins casein, whey, cod, and gluten, added to a fat-rich meal, all decreased the @entity2289 and FVIIc concentrations postprandially in @entity164 2 @entity6 subjects. However, postprandial levels of @entity2289 and FVIIc were not acutely influenced by the protein source.

title: Effects of different protein sources on plasminogen inhibitor-1 and factor VII coagulant activity added to a fat-rich meal in XXXX 2 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2289 :: ('5054', 'Gene') :: ['PAI-1', 'plasminogen inhibitor 1']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: BACKGROUND: Exaggerated postprandial @entity412 concentration is believed to be atherogenic, and to influence the risk of @entity715 . Both elevated @entity2289 ( @entity2289 ) and increased factor VII coagulant activity (FVIIc) are potential important contributors to the increased risk of @entity65 in @entity164 2 @entity6 . AIM: We aimed to investigate the effect of adding four different protein types (i.e. casein, whey, cod, and gluten) to a fat-rich meal on postprandial responses of @entity2289 and FVIIc in @entity164 2 @entity6 @entity1 . METHODS: Twelve @entity164 2 @entity6 @entity1 ingested four isocaloric test meals in random order. The test meals contained 100 g of butter and 45 g of @entity1735 in combination with 45 g of casein (Cas-meal), whey (Whe-meal), cod (Cod-meal), or gluten ( @entity367 -meal), respectively. Plasma concentrations of @entity2289 and FVIIc were measured before meal, and at regular intervals for 8-h postprandially. RESULTS: The postprandial @entity2289 concentration decreased significantly by 49% to 56% in response to the four test meals. There were no significant differences between the outcomes from the four test-meals. The FVIIc levels decreased by 8% to 11% after the meals. Again, we observed no significant differences in outcomes between the four protein-enriched meals. CONCLUSIONS: The four proteins casein, whey, cod, and gluten, added to a fat-rich meal, all decreased the @entity2289 and FVIIc concentrations postprandially in @entity164 2 @entity6 subjects. However, postprandial levels of @entity2289 and FVIIc were not acutely influenced by the protein source.

title: Effects of different protein sources on plasminogen inhibitor-1 and factor VII coagulant activity added to a fat-rich meal in @entity164 2 XXXX .

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: OBJECTIVE: The purpose of the study was to assess patterns of primary pancreatic lesions by contrast-enhanced sonography for differentiating @entity513 from other @entity788 . METHODS: One hundred six consecutive @entity1 with pancreatic masses, consisting of 83 @entity189 , 5 intraductal papillary mucinous @entity5 , 3 cases of autoimmune-related @entity788 , 3 solid @entity5 , 2 cases of chronic @entity788 , 1 @entity12679 , 1 @entity2967 , and 1 @entity706 , were examined by contrast-enhanced sonography with coded harmonic imaging in a phase inversion harmonic technique. The contrast enhancement patterns were assessed, and specimens removed during pancreatectomy were subjected to pathologic examination. RESULTS: Internal tumoral vascularity was detected in 47 (56.6%) of the 83 @entity513 . Vascular image spreading and homogeneous staining throughout the @entity5 were observed in all endocrine @entity189 . Two of the 5 intraductal papillary mucinous @entity5 were positive for enhancement effects. Enhancement effects were observed in all 3 cases of autoimmune-related @entity788 , but the degree varied. There was a significant correlation between the intensity of enhancement effects and the ratio of patent vessels in the @entity5 (P < .05). CONCLUSIONS: Vascularity was detected by contrast-enhanced sonography in only about half of the @entity513 , confirming the difficulty in distinguishing those @entity5 from other @entity788 . There was a correlation between the patency of the vessels in the @entity5 and their vascularity.

title: Evaluation of contrast enhancement patterns in XXXX by coded harmonic sonographic imaging with a microbubble contrast agent.

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'pancreatic tumors']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['follicular lymphoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['pseudopapillary tumors', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'ductal carcinomas, 7 endocrine carcinomas']

entities_list: @entity2967 :: ('MESH:D005870', 'Disease') :: ['osteoclastoid giant cell tumor']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinomas']

entities_list: @entity12679 :: ('MESH:D018293', 'Disease') :: ['serous cystadenoma']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic tumors']


abstract: BACKGROUND: @entity6711 ( @entity6711 ) immunotherapy has proven efficacy in treating @entity2023 ( @entity2023 ) symptoms. This trial evaluated the dose-response relationship of SLIToneULTRA   @entity6711 mix based on immunological parameters and safety in subjects with moderate-to-severe @entity6711 @entity2023 not controlled by symptomatic medication. MATERIALS AND METHODS: A randomized, parallel-group, open-label, clinical trial compared 50/150/300 standard reactivity unit (SRU) doses of SLIToneULTRA   @entity6711 mix for 6 months. Subjects had moderate-to-severe @entity6711 @entity2023 , positive skin prick and IgE against @entity7130 / @entity8786 (DP/DF). The primary end point was change from baseline in the IgE-blocking factor against DP after 6 months. Secondary end points measured changes in the IgE-blocking factor for DP at 3 months and for DF at 3 and 6 months, and in IgG4 and specific IgE to DP/DF after 3 and 6 months. Tolerability was assessed through the evaluation of all adverse events (AEs). RESULTS: A total of 219 subjects were randomized and 196 completed the trial. Dose effect was significant on DP IgE-BF after 6 months (p = 0.018). The change in the DP IgE-blocking factor at a 300-SRU dose was higher than at other doses after 3 (p = 0.008) and 6 (p = 0005) months of treatment. Similar changes were observed for IgG4 and allergen-specific IgE. The number of AEs increased with the dose and were mild-to-moderate, with no severe treatment-related AEs reported. The most frequent AEs were @entity5773 , mouth @entity4 and @entity490 . CONCLUSIONS: Data showed a dose-response for immunological markers and safety with a better immunological response for 300 SRU. The highest dose (300 SRU daily) was considered as the optimal maintenance dose.

title: Dose-Dependent Immunological Responses after a 6-Month Course of Sublingual House Dust Mite Immunotherapy in Patients with XXXX .

entities_list: @entity5773 :: ('MESH:D014060', 'Disease') :: ['oral/tongue pruritus']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['AR', 'allergic rhinitis']

entities_list: @entity7130 :: ('6956', 'Species') :: ['Dermatophagoides pteronyssinus']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema']

entities_list: @entity8786 :: ('6954', 'Species') :: ['Dermatophagoides farinae']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal upper pain']

entities_list: @entity6711 :: ('MESH:D008924', 'Disease') :: ['HDM', 'House dust mite']

answer: @entity2023 :: (MESH:D006255,Disease) :: ['Allergic Rhinitis']


abstract: OBJECTIVE: To evaluate the results of TSRH instrumentation in the correction of coronal, sagittal and @entity717 of @entity1635 . METHODS: From January 1998 to December 1999, thirty-two consecutive @entity1 (6 males, 26 females)with @entity1635 underwent anterior or posterior spinal instrumentation and fusion using TSRH instrumentation. Of these cases, 21 were @entity2112 and 11 were @entity1635 . The average age at surgery was 16.4 years (range, 11 approximately 45 years). The mean Cobb angle at surgery was 71.2 degrees range, 44 degrees approximately 125 degrees) in the coronal plane, and 49. degrees range, 16 degrees aprroximately 67degrees in the sagittal plane. @entity717 (Nash-Moe) ranged from I to III degree. Preoperative apical translation averaged 4.8 cm (range, 3 approximately 9 cm). RESULTS: The average follow-up duration was 13.3 months (range, 10 approximately 24 months). At the final follow-up, the mean Cobb angle in the coronal plane was 26.6 (range, 10 degrees approximately 73 degrees), with a 63.8% of improvement. Sagittal alignment was well maintained with a mean Cobb angle of 28 degrees (range, 10 degrees approximatelky 45 degrees). The average correction of rotation of the apical vertebra was I degree. The average apical translation was 1.6 cm (range, 0.5 approximately 5.0 cm) representing a correction rate of 66, 7%. Complication was noted in two cases with an incidence of 3.1%, one case had superficial infection and the other one had lower hook dislocation. There was no neurologic deficit and pseudoarthrodesis in this series. CONCLUSION: TSRH instrumentation is an effective and convenient three-dimensional correction system with a lower rate of complication, which can not only correct the @entity717 , but maintain the sagittal alignment as well.

title: Three-dimensional correction of XXXX using TSRH instrumentation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Rotational deformity', 'rotational deformity', 'coronal and rotational deformity']

entities_list: @entity2112 :: ('MESH:C564593', 'Disease') :: ['idiopathic scoliosis']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis', 'congenital scoliosis']

answer: @entity1635 :: (MESH:D012600,Disease) :: ['scoliosis']


abstract: PURPOSE: Acute dislocation of the peroneal tendon is caused by massive combined flexion-torsion @entity130 supported by preexisting @entity10089 of the ankle joint. This study aimed to investigate the clinical outcome of combined treatment of peroneal @entity924 and lateral and medial @entity10089 . METHODS: Between 2005 and 2007, forty-two @entity1 with peroneal @entity924 and coexisting @entity10089 were treated. The superior extensor retinaculum was reconstructed using anchor technique and periosteal flap repair, whereas the preexisting @entity10089 with regard to the extensor inferior retinaculum was addressed using anchor reconstruction. All @entity1 underwent arthroscopy prior to surgery. Thirty-eight of a total of 42 @entity1 (aged 17-31) completed the 24-month follow-up. Clinical and arthroscopic examination was accomplished consistently by always the same two surgeons. Postoperative follow-up comprised clinical evaluation after 3, 6, 12 and 24 months. RESULTS: Clinical results showed a significant (P<0.0001) increase in the AOFAS-Hindfoot Score as an often used but not validated outcome measure, as well as a significant decrease in the Visual Analogue Scale and in the internal and external rotation, after 3 months. The clinical outcome was confirmed at the 6-, 12- and 24-months measuring points. No dislocation of the peroneal tendon recurred within the 24-month follow-up. Subjective @entity1 satisfaction was stated as high. CONCLUSIONS: Combined treatment of peroneal @entity924 and coexisting lateral and medial @entity10089 in the ankle joint following arthroscopy results in good clinical outcome and high @entity1 satisfaction. LEVEL OF EVIDENCE: Case series, Level IV.

title: Treatment of peroneal @entity924 and coexisting medial and lateral XXXX in the ankle joint.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['tendon dislocation']

entities_list: @entity10089 :: ('MESH:C536012', 'Disease') :: ['ligamentous laxity']

answer: @entity10089 :: (MESH:C536012,Disease) :: ['ligamentous laxity']


abstract: PURPOSE: Acute dislocation of the peroneal tendon is caused by massive combined flexion-torsion @entity130 supported by preexisting @entity10089 of the ankle joint. This study aimed to investigate the clinical outcome of combined treatment of peroneal @entity924 and lateral and medial @entity10089 . METHODS: Between 2005 and 2007, forty-two @entity1 with peroneal @entity924 and coexisting @entity10089 were treated. The superior extensor retinaculum was reconstructed using anchor technique and periosteal flap repair, whereas the preexisting @entity10089 with regard to the extensor inferior retinaculum was addressed using anchor reconstruction. All @entity1 underwent arthroscopy prior to surgery. Thirty-eight of a total of 42 @entity1 (aged 17-31) completed the 24-month follow-up. Clinical and arthroscopic examination was accomplished consistently by always the same two surgeons. Postoperative follow-up comprised clinical evaluation after 3, 6, 12 and 24 months. RESULTS: Clinical results showed a significant (P<0.0001) increase in the AOFAS-Hindfoot Score as an often used but not validated outcome measure, as well as a significant decrease in the Visual Analogue Scale and in the internal and external rotation, after 3 months. The clinical outcome was confirmed at the 6-, 12- and 24-months measuring points. No dislocation of the peroneal tendon recurred within the 24-month follow-up. Subjective @entity1 satisfaction was stated as high. CONCLUSIONS: Combined treatment of peroneal @entity924 and coexisting lateral and medial @entity10089 in the ankle joint following arthroscopy results in good clinical outcome and high @entity1 satisfaction. LEVEL OF EVIDENCE: Case series, Level IV.

title: Treatment of peroneal XXXX and coexisting medial and lateral @entity10089 in the ankle joint.

answer: @entity924 :: (MESH:D052256,Disease) :: ['tendon dislocation']


abstract: OBJECTIVE: To introduce a new spinal internal fixation system, @entity580 ( @entity580 ), and to investigate its early clinical outcomes. METHODS: The preliminary clinical outcomes of 15 @entity1 with thoracolumbar or lumbar @entity1635 treated by anterior spinal fusion with @entity580 instrumentation were studied retrospectively. Fourteen @entity1 were diagnosed as @entity2112 and 1 as @entity4094 . RESULTS: Preoperatively, the Cobb's angle on the coronal plane was 55.8 degrees (range 35 degrees to approximately 78 degrees), and 14 degrees postoperatively, with an average correction of 74.8%. The average unfused thoracical curve was 35.9 degrees preoperatively (range 26 degrees to approximately 51 degrees) and 21.8 degrees (10 degrees to approximately 42 degrees) postoperatively, with 40% correction. The sagittal curve of lumbar was kept physiologically, preoperative 27.9 degrees and postoperative 25.7 degrees respectively. The trunk shift was 13.4 mm (5 to approximately 28 mm) preoperatively and 3.5 mm (0 to approximately 7 mm) postoperatively. The averaged apic vertebra derivation was 47.8 mm (21 to approximately 69 mm) before operation and 10.8 mm (3 to approximately 20 mm) after operation. The distance of C7 to center sacrum vertical line (CSVL) was 19.5 mm (16 to approximately 42) preoperatively and 11.3 mm (0 to approximately 32 mm) postoperatively. The apical vertebra rotation was 3 degree in 15 @entity1 preoperatively, and were improved to normal in 10 @entity1 , 1 degree in 4 @entity1 , and 2 degree in 1 @entity1 postoperatively. None had @entity16 and @entity281 . Only 1 @entity1 complained a cool feeling in the low extremity of concave side, and the symptom vanished at 3-month followed up. CONCLUSION: If used appropriately, @entity580 anterior spinal system is a good teatment for low thoracic or @entity1514 .

title: Anterior spinal fusion with @entity580 instrumentation for XXXX .

entities_list: @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular scoliosis']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological injury']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic lumbar scoliosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity580 :: ('MESH:D003428', 'Disease') :: ['Texas Scottish Rite Hospital', 'TSRH']

answer: @entity1635 :: (MESH:D012600,Disease) :: ['scoliosis']


abstract: OBJECTIVE: To introduce a new spinal internal fixation system, @entity580 ( @entity580 ), and to investigate its early clinical outcomes. METHODS: The preliminary clinical outcomes of 15 @entity1 with thoracolumbar or lumbar @entity1635 treated by anterior spinal fusion with @entity580 instrumentation were studied retrospectively. Fourteen @entity1 were diagnosed as @entity2112 and 1 as @entity4094 . RESULTS: Preoperatively, the Cobb's angle on the coronal plane was 55.8 degrees (range 35 degrees to approximately 78 degrees), and 14 degrees postoperatively, with an average correction of 74.8%. The average unfused thoracical curve was 35.9 degrees preoperatively (range 26 degrees to approximately 51 degrees) and 21.8 degrees (10 degrees to approximately 42 degrees) postoperatively, with 40% correction. The sagittal curve of lumbar was kept physiologically, preoperative 27.9 degrees and postoperative 25.7 degrees respectively. The trunk shift was 13.4 mm (5 to approximately 28 mm) preoperatively and 3.5 mm (0 to approximately 7 mm) postoperatively. The averaged apic vertebra derivation was 47.8 mm (21 to approximately 69 mm) before operation and 10.8 mm (3 to approximately 20 mm) after operation. The distance of C7 to center sacrum vertical line (CSVL) was 19.5 mm (16 to approximately 42) preoperatively and 11.3 mm (0 to approximately 32 mm) postoperatively. The apical vertebra rotation was 3 degree in 15 @entity1 preoperatively, and were improved to normal in 10 @entity1 , 1 degree in 4 @entity1 , and 2 degree in 1 @entity1 postoperatively. None had @entity16 and @entity281 . Only 1 @entity1 complained a cool feeling in the low extremity of concave side, and the symptom vanished at 3-month followed up. CONCLUSION: If used appropriately, @entity580 anterior spinal system is a good teatment for low thoracic or @entity1514 .

title: Anterior spinal fusion with XXXX instrumentation for @entity1635 .

answer: @entity580 :: (MESH:D003428,Disease) :: ['TSRH']


abstract: BACKGROUND: The aim of this study was to compare two different sympathicotomy procedures for primary @entity1119 in terms of @entity3190 , complications, safety and effectiveness. METHODS: The data of 78 consecutive @entity1 who underwent bilateral endoscopic thoracic sympathicotomy (156 laterals) for @entity1119 between January 2005 and September 2009 were studied retrospectively. The first 29 consecutive @entity1 were treated with a T2-3 sympathicotomy (Group A). After November 2007, all @entity1 (49 @entity1 ) were treated with a T3 sympathicotomy alone (Group B). The chest tubes were always removed after checking for pneumothorax with roentgenography. All @entity1 were followed up and evaluated for results, side effects, complications, and satisfaction levels. The differences between the two groups were analyzed. RESULTS: The mean age of the 47 (60.2%) female and 31 (39.8%) male @entity1 was 25.2 years. @entity4820 and pneumothorax was not detected in either group. The mean follow-up time was 20.82 months (6-52 months). Effectiveness of the procedure at the time of discharge and at follow-up was 100% and 97.5%, respectively. There was no significant difference between groups with regard to any analyzed parameter. CONCLUSION: This study demonstrates that preserving the T2 ganglion is safe, and does not compromise the effectiveness of the procedure. Sympathicotomy has the same success rate as sympathectomy, but requires significantly less dissection and results in less tissue @entity130 .

title: Preserving T2 in thoracic sympathicotomy for XXXX : less tissue @entity130 , same effectiveness.

entities_list: @entity1119 :: ('MESH:D006945', 'Disease') :: ['palmar hyperhidrosis', 'hyperhidrosis']

entities_list: @entity3190 :: ('MESH:D006946', 'Disease') :: ['compensatory sweating']

entities_list: @entity4820 :: ('MESH:D006732', 'Disease') :: ["Horner's syndrome"]

answer: @entity1119 :: (MESH:D006945,Disease) :: ['palmar hyperhidrosis']


abstract: BACKGROUND: The aim of this study was to compare two different sympathicotomy procedures for primary @entity1119 in terms of @entity3190 , complications, safety and effectiveness. METHODS: The data of 78 consecutive @entity1 who underwent bilateral endoscopic thoracic sympathicotomy (156 laterals) for @entity1119 between January 2005 and September 2009 were studied retrospectively. The first 29 consecutive @entity1 were treated with a T2-3 sympathicotomy (Group A). After November 2007, all @entity1 (49 @entity1 ) were treated with a T3 sympathicotomy alone (Group B). The chest tubes were always removed after checking for pneumothorax with roentgenography. All @entity1 were followed up and evaluated for results, side effects, complications, and satisfaction levels. The differences between the two groups were analyzed. RESULTS: The mean age of the 47 (60.2%) female and 31 (39.8%) male @entity1 was 25.2 years. @entity4820 and pneumothorax was not detected in either group. The mean follow-up time was 20.82 months (6-52 months). Effectiveness of the procedure at the time of discharge and at follow-up was 100% and 97.5%, respectively. There was no significant difference between groups with regard to any analyzed parameter. CONCLUSION: This study demonstrates that preserving the T2 ganglion is safe, and does not compromise the effectiveness of the procedure. Sympathicotomy has the same success rate as sympathectomy, but requires significantly less dissection and results in less tissue @entity130 .

title: Preserving T2 in thoracic sympathicotomy for @entity1119 : less tissue XXXX , same effectiveness.

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: BACKGROUND: Hybrid video-assisted thoracic surgery (hybrid VATS), combining television monitoring and direct visualization through mini-thoracotomy, has been established as a secure and minimally invasive operation for @entity2 . This study aimed to determine @entity282 levels after hybrid VATS in which intraoperative internal intercostal nerve block is performed. We also examined whether additional use of postoperative continuous infusion of @entity3575 improves @entity282 control. METHODS: Data from 131 @entity1 undergoing hybrid VATS were retrospectively analyzed. Thoracoscopic, internal intercostal nerve block was performed at the end of the procedure. @entity282 levels after hybrid VATS, and the impact of postoperative continuous infusion of @entity3575 on @entity282 levels and the incidence of @entity1209 ( @entity1209 ) were examined. RESULTS: 46.6% of @entity1 experienced severe @entity282 (numerical rating scale 7-10) after hybrid VATS. Postoperative continuous infusion of @entity3575 was not associated with reduction in @entity282 score, but was independently associated with @entity1209 [odds ratio 3.44 (1.52-8.20); P = 0.0027]. CONCLUSIONS: Intraoperative internal intercostal nerve block did not provide sufficient @entity1337 after hybrid VATS. Additional use of postoperative continuous infusion of @entity3575 did not reduce @entity158 score, but increased the incidence of @entity1209 .

title: [Postoperative XXXX after Hybrid Video-assisted Thoracic Surgery].

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain', 'Postoperative pain']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['PONV', 'postoperative nausea and vomiting']

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: BACKGROUND: Wound dehiscence complicated by gastrointestinal (GI) @entity292 to belong ,, @entity1661 ". Therapy is prolonged and connected with high morbidity and mortality rate. METHODS: In the period from October 2006 to July 2009 we performed 12 reconstructive surgical procedures on gastrointestinal tract in @entity1 with @entity1661 . Treatment of 12 consecutive @entity1 (9 @entity1 , 3 @entity1 ) was managed according to a standardize protocol. The protocol consists of treatment of septic complications, optimisation of nutritional state, special wound procedures, diagnosis of @entity344 and GI tract, timing of surgical procedures, reconstruction of GI tract and postoperative care. RESULTS: Reconstructive surgery of GI tract was successful on 11 @entity1 . One @entity1 developed recurrence of @entity344 . In four @entity1 we let open abdomen to heal per secundam. We observed no deaths after operation. CONCLUSION: With regard to complex character of therapy of @entity1661 there is a need of multidisciplinary approach. Considering long-lasting and expensive therapy there is logical step to concentrate these @entity1 into special centres which are experienced, equipped and their staff is trained in treatment of such a seriously impaired @entity1 .

title: [Abdominal catastrophe--abdominal wall defect associated with XXXX --strategy of therapy].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal catastrophe']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal fistulas', 'early GI fistula']

answer: @entity344 :: (MESH:D005767,Disease) :: ['gastrointestinal fistula']


abstract: INTRODUCTION: Perceptual evaluation is considered the gold standard to evaluate speech nasality. Several procedures are used to collect and analyze perceptual data, which makes it susceptible to errors. Therefore, there has been an increasing desire to find methods that can improve the assessment. OBJECTIVE: To describe and compare the results of speech nasality obtained by assessments of live speech, the Test of @entity2422 (THYPER), assessments of audio recorded speech, and nasometry. METHODS: A retrospective study consisting of 331 @entity1 with operated @entity3384 . Speech nasality was assessed by four methods of assessment: live perceptual judgement, THYPER, audio-recorded speech sample judgement by multiple judges, and nasometry. All data were collected from medical records of @entity1 , with the exception of the speech sample recording assessment, which was carried out by multiple judges. RESULTS: The results showed that the highest percentages of absence of @entity2422 were obtained from judgements performed live and from the THYPER, with equal results between them (79%). Lower percentages were obtained from the recordings by judges (66%) and from nasometry (57%). CONCLUSION: The best results among the four speech nasality evaluation methods were obtained for the ones performed live (live nasality judgement by a speech pathologist and THYPER).

title: Speech nasality and nasometry in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3384 :: ('MESH:D002971', 'Disease') :: ['unilateral cleft lip and palate']

entities_list: @entity2422 :: ('MESH:C537724', 'Disease') :: ['Hypernasality', 'hypernasality']

answer: @entity3384 :: (MESH:D002971,Disease) :: ['cleft lip and palate']


abstract: Isovolumetrically contracting left ventricle of the anesthetized @entity235 was used to evaluate the end-diastolic pressure-volume relationship [LVEDP (P)-LVEDV (V) relationship (curve)] following changes in heart rate, @entity63 and administration of beta-adrenergic blocking drug. At the same time, relaxation indices were also obtained. Initial left ventricular volume was set at the end-diastolic pressure of 2.0 mmHg. Comparison of each parameters after intervention was done when each initial left ventricular volume was increased by 10 ml. With increase in heart rate, LVEDP increased significantly from 5.1 +/- 2.1 to 14.0 +/- 2.2 mmHg (at 160 bpm, p less than 0.02, vs 100 bpm) and to 24.0 +/- 1.0 mmHg (at 180 bpm, vs p less than 0.001, vs 100 bpm). Regional @entity63 also increased LVEDP significantly from 6.4 +/- 1.4 mmHg to 12.8 +/- 4.1 mmHg (after 30 min, p less than 0.01, vs control) and to 14.1 +/- 4.7 mmHg (after 45 min, p less than 0.01, vs control). However, global @entity63 produced by decreasing coronary perfusion pressure to 50 mmHg, or administration of @entity1169 (1.0 mg/kg) brought about no significant changes in LVEDP. Among the relaxation indices, peak negative dp/dt decreased significantly following global @entity63 , regional @entity63 and administration of @entity1169 (from 1101 +/- 131 to 733 +/- 49 mmHg/sec, p less than 0.01, from 888 +/- 425 to 268 +/- 94 mmHg/sec after 45 min, p less than 0.01 and from 562 +/- 160 to 291 +/- 100 mmHg/sec, p less than 0.01, respectively). On the other hand, time constant (T) of the left ventricular pressure fall was prolonged significantly following regional @entity63 from 44.7 +/- 5.2 to 72.0 +/- 8.6 msec (after 30 min, p less than 0.001) and 95.4 +/- 26.0 msec (after 30 min, p less than 0.001) and 95.4 +/- 26.0 msec (after 45 min, p less than 0.001). Therefore, it is concluded that LV diastolic compliance decreases by @entity591 (160 and 180 bpm) and regional @entity63 , while the changes of the relaxation indices were not necessarily parallel to those of the LV compliance.

title: [The diastolic pressure-volume relationship of the left ventricle--evaluation of XXXX isovolumetric contracting left ventricle].

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

answer: @entity235 :: (9615,Species) :: ['canine']


abstract: UNASSIGNED: Bed rest, a ground-based spaceflight analog, induces robust @entity194 of skeletal muscle, an effect that is exacerbated with increasing age. We examined the effect of 14 days of bed rest on skeletal muscle satellite cell content and fiber @entity194 in middle-aged adults, an understudied age demographic with few overt signs of muscle aging that is representative of astronauts who perform long-duration spaceflight. Muscle biopsies were obtained from the vastus lateralis of healthy middle-aged adults (n=7 [4M;3F]; age: 51  1 y) before (Pre-BR) and after (Post-BR) 14 days of bed rest. Immunohistochemical analyses were used to quantify @entity9740 ( @entity9740 ) isoform expression, cross-sectional area (CSA), satellite cell and myonuclear content, and capillary density. Peak @entity26 consumption, knee extensor strength, and body composition were also measured Pre- and Post-BR. Post-BR @entity9740 Type 2a fiber percentage was reduced and mean CSA decreased in all fiber types (-24  5%; P<0.05). Satellite cell content was also reduced Post-BR (-39  9%; P<0.05) and the change in satellite cell content was significantly correlated with the change in mean fiber CSA (R2=0.60; P<0.05). A decline in capillary density was observed Post-BR (-23  6%; P<0.05), and Post-BR capillary content was significantly associated with Post-BR peak aerobic capacity (R2=0.59; P<0.05). A subtle decline in myonuclear content occurred during bed rest (-5  1%; P<0.05). The rapid maladaptation of skeletal muscle to 14 days of mechanical unloading in middle-aged adults emphasizes the need for robust countermeasures to preserve muscle function in astronauts.

title: 14 days of bed rest induces a decline in satellite cell content and robust XXXX of skeletal muscle fibers in middle-aged adults.

entities_list: @entity9740 :: ('4624', 'Gene') :: ['MyHC', 'myosin heavy chain']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['type atrophy', 'atrophy']

answer: @entity194 :: (MESH:D001284,Disease) :: ['atrophy']


abstract: OBJECTIVE: To compare the hematopoietic support provided by telomerized @entity1 mesenchymal stem cells (MSCs) and telomerized MSC-derived stromal cells. METHODS: We transfected the @entity1 @entity2215 (hTERT) gene into primary MSCs to establish hTERT-transduced MSCs (hTERT-MSCs). Stromal induction of hTERT-MSCs was performed by replacing the culture medium with Dexter-type culture medium. @entity1583 support was examined by coculture with cord blood @entity2280 (+) cells. RESULTS: The hTERT-MSCs were morphologically identical with the primary MSCs and expressed surface antigens including CD105, @entity12359 , and @entity2394 . hTERT-MSCs showed a similar doubling time as primary MSCs and continued to proliferate to over 80 @entity14485 ( @entity14485 ), although the primary MSCs underwent crisis in vitro at 16 @entity14485 . The osteogenic, chondrogenic, adipogenic, neurogenic, and stromal differentiation potential of hTERT-MSCs were maintained up to at least 40 @entity14485 . The degree of expansion of @entity2280 (+) cells and total number of colony-forming units in culture (CFU-C) upon 12-day coculture with the hTERT-MSC-derived stromal cells were nearly the same as those upon 12-day coculture with hTERT-MSCs ( @entity2280 , 33.0-fold+/-2.8-fold vs 36.1-fold+/-1.7-fold of the initial cell number; CFUs, 344.4-fold+/-62.5-fold vs 239.3-fold+/-87.0-fold; CFU-mix, 368.4-fold+/-113.7-fold vs 341.3-fold+/-234.3-fold). However, on day 18 of coculture, the number of cobblestone areas (CA) observed beneath the stromal cells was 15 times higher than that beneath hTERT-MSCs (CA, 146.9+/-54.6 vs 9.4+/-8.1, p<0.01). CONCLUSION: Stromal induction of hTERT-MSCs exclusively enhanced the support of CA formation provided by hTERT-MSCs. Our @entity1 hTERT-MSCs will be useful for elucidating the mechanism of the formation of CAs.

title: Telomerized XXXX multipotent mesenchymal cells can differentiate into hematopoietic and cobblestone area-supporting cells.

entities_list: @entity14485 :: ('MESH:D005671', 'Disease') :: ['population doublings', 'PD']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['Hematopoietic']

entities_list: @entity2215 :: ('7015', 'Gene') :: ['telomerase catalytic subunit']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: The presence of @entity5 in advanced @entity5 @entity1 is associated with both a poor prognosis and quality of life with a risk of @entity1320 and @entity295 . Contemporary noninvasive visualization methods such as ultrasound, computed tomography, and magnetic resonance imaging (MRI) often struggle to differentiate @entity5 from surrounding tissues. This study aimed to determine the utility of selective @entity4358 imaging in the abdominal cavity with a free radical probe and @entity20962 ( @entity2768 ) contrast agent using in vivo dynamic nuclear polarization-MRI (DNP-MRI). Phantom imaging experiments established a linear relationship between @entity4358 volume and image intensity using in vivo DNP-MRI. Similar results were obtained when the radical-D2O probe was used to determine selective and spatial information on @entity4358 in vivo, modeled by the injection of saline into the abdominal cavity of @entity19 . To demonstrate the utility of this method for disease, @entity5 in peritoneal @entity3 animal model was selected as one of the typical examples. In vivo DNP-MRI of peritoneal @entity3 animal model was performed 7-21 days after intraperitoneal injection of luciferase, stably expressing the @entity1 @entity3123 (SUIT-2). The image intensity with increasing @entity5 was significantly increased at days 7, 16, and 21. This increase corresponded to in vivo @entity5 progression, as measured by bioluminescent imaging. These results suggest that @entity4358 signal enhancement in DNP-MRI using radical-D2O contrast is positively associated with the progression of dissemination and could be a useful biomarker for @entity5 with @entity5 @entity3 .

title: Selective Imaging of Malignant Ascites in a @entity19 Model of Peritoneal XXXX Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity3123 :: ('MESH:C562463', 'Disease') :: ['pancreatic carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant ascites', 'tumor', 'cancer']

entities_list: @entity20962 :: ('MESH:D017666', 'Chemical') :: ['deuterium oxide']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['abdominal infection']

answer: @entity3 :: (MESH:D009362,Disease) :: ['Metastasis']


abstract: UNASSIGNED: The presence of @entity5 in advanced @entity5 @entity1 is associated with both a poor prognosis and quality of life with a risk of @entity1320 and @entity295 . Contemporary noninvasive visualization methods such as ultrasound, computed tomography, and magnetic resonance imaging (MRI) often struggle to differentiate @entity5 from surrounding tissues. This study aimed to determine the utility of selective @entity4358 imaging in the abdominal cavity with a free radical probe and @entity20962 ( @entity2768 ) contrast agent using in vivo dynamic nuclear polarization-MRI (DNP-MRI). Phantom imaging experiments established a linear relationship between @entity4358 volume and image intensity using in vivo DNP-MRI. Similar results were obtained when the radical-D2O probe was used to determine selective and spatial information on @entity4358 in vivo, modeled by the injection of saline into the abdominal cavity of @entity19 . To demonstrate the utility of this method for disease, @entity5 in peritoneal @entity3 animal model was selected as one of the typical examples. In vivo DNP-MRI of peritoneal @entity3 animal model was performed 7-21 days after intraperitoneal injection of luciferase, stably expressing the @entity1 @entity3123 (SUIT-2). The image intensity with increasing @entity5 was significantly increased at days 7, 16, and 21. This increase corresponded to in vivo @entity5 progression, as measured by bioluminescent imaging. These results suggest that @entity4358 signal enhancement in DNP-MRI using radical-D2O contrast is positively associated with the progression of dissemination and could be a useful biomarker for @entity5 with @entity5 @entity3 .

title: Selective Imaging of Malignant Ascites in a XXXX Model of Peritoneal @entity3 Using in Vivo Dynamic Nuclear Polarization-Magnetic Resonance Imaging.

answer: @entity19 :: (10090,Species) :: ['Mouse']


abstract: AIMS: We evaluated if killer cell immunoglobulin-like receptor 3DL2 gene ( @entity30026 ) polymorphisms are a key factor in the development of @entity1468 . METHODS: In this case-control study, 105 pregnant @entity1 with PE (PE group) were enrolled. Their @entity72789 in exon 3 and @entity72790 in exon 9 polymorphisms of the @entity30026 genotypes were determined by polymorphism chain reaction-restriction fragment length polymorphism (PCR-RFLP) from venous blood samples and compared with the corresponding @entity30026 genotypes of 103 pregnant @entity1 with uncomplicated pregnancies (control group). RESULTS: Carriers of the A allele in exon 3 of @entity30026 gene occurred less frequently in PE than in controls [P=0.001; odds ratio (OR)=2.65, range: 1.5-4.7]. No significant difference was found about allelic frequencies of @entity30026 gene @entity72790 in exon 9 in @entity1 with @entity1468 as compared to controls. A significant difference between the two groups of genotypic frequencies of @entity30026 gene @entity72789 in exon 3 and @entity30026 gene @entity72790 in exon 9 polymorphisms was found (P=0.003 and P=0.000). There was no significant difference between genotypic or allelic frequencies in @entity1 with mild @entity1468 compared to sever @entity1468 . CONCLUSIONS: Our results suggest that carriers of A allele in exon 3 have a decreased susceptibility to PE. It is likely that the presence of the CC genotype in exon 9 has a considerable effect on disease progression. The mutation of the two sites is not associated with the severity of @entity1468 .

title: Genetic polymorphisms of killer cell immunoglobulin-like receptor 3DL2 in XXXX .

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']

answer: @entity1468 :: (MESH:D011225,Disease) :: ['preeclampsia']


abstract: Thirty-two @entity1 treated for @entity5249 were retrospectively reviewed. The results of treatment were assessed by clinical and radiographic parameters and arbitrarily classified good, fair, or poor. Five @entity1 were definitively treated with braces; five extremities were rated good and one poor. Twelve @entity1 were treated with a proximal tibial osteotomy performed before their fifth birthday. Nineteen extremities were rated good, one fair, and three poor. Fifteen @entity1 had their initial surgical procedure after the fifth birthday. Eight extremities were rated good, six fair, and seven poor. Recurrence of the @entity85 secondary to an unsuspected medial bony physeal bar occurred in four @entity1 . Resection of this bony bridge concomitant with a varus correcting osteotomy may be indicated. For severe @entity85 in older @entity1 , several different salvage procedures were used.

title: XXXX : a retrospective review and recommendations for treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['deformity', 'varus deformity']

entities_list: @entity5249 :: ('MESH:C536237', 'Disease') :: ["Blount's disease"]

answer: @entity5249 :: (MESH:C536237,Disease) :: ['Blount's disease']


abstract: The detection of either impairment of coronary flow reserve at rest or abnormalities of regional myocardial function during an @entity63 stress are both means of defining the physiologic significance of @entity3979 . The relation between these two indexes has not been defined previously, particularly in the setting of mild @entity73 of coronary flow reserve. Therefore, this relation was investigated in nine open chest anesthetized @entity235 . Graded, subcritical @entity3979 were produced that impaired postocclusion hyperemic flow, but not coronary blood flow at rest. Subendocardial ultrasonic crystals were used to measure segment length shortening at rest and after maximal atrial pacing. There was a curvilinear relation between pacing-induced deterioration of segment length shortening and @entity73 at rest with the most substantial decrease in regional function occurring when less than 20 to 40% of control reactive @entity450 remained. This corresponded to a reactive hyperemic ratio between 1.7 and 2.3. This nonlinear relation was paralleled by the relation between deterioration of regional function and the percent of control blood flow recorded at the time of regional postpacing dysfunction in the presence of @entity3979 . It is concluded that coronary flow reserve may be substantially reduced before regional dysfunction induced by atrial pacing becomes pronounced. The extent of regional dysfunction during atrial pacing is, in large part, due to the alterations in coronary blood flow occurring during this form of stress in the presence of @entity3979 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Relation between graded, XXXX of coronary flow reserve and regional myocardial dysfunction induced by atrial pacing in @entity235 .

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment in reactive hyperemia', 'subtotal impairment']

entities_list: @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia']

entities_list: @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary stenosis', 'coronary stenoses']

answer: @entity73 :: (MESH:D003072,Disease) :: ['subcritical impairments']


abstract: The detection of either impairment of coronary flow reserve at rest or abnormalities of regional myocardial function during an @entity63 stress are both means of defining the physiologic significance of @entity3979 . The relation between these two indexes has not been defined previously, particularly in the setting of mild @entity73 of coronary flow reserve. Therefore, this relation was investigated in nine open chest anesthetized @entity235 . Graded, subcritical @entity3979 were produced that impaired postocclusion hyperemic flow, but not coronary blood flow at rest. Subendocardial ultrasonic crystals were used to measure segment length shortening at rest and after maximal atrial pacing. There was a curvilinear relation between pacing-induced deterioration of segment length shortening and @entity73 at rest with the most substantial decrease in regional function occurring when less than 20 to 40% of control reactive @entity450 remained. This corresponded to a reactive hyperemic ratio between 1.7 and 2.3. This nonlinear relation was paralleled by the relation between deterioration of regional function and the percent of control blood flow recorded at the time of regional postpacing dysfunction in the presence of @entity3979 . It is concluded that coronary flow reserve may be substantially reduced before regional dysfunction induced by atrial pacing becomes pronounced. The extent of regional dysfunction during atrial pacing is, in large part, due to the alterations in coronary blood flow occurring during this form of stress in the presence of @entity3979 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Relation between graded, @entity73 of coronary flow reserve and regional myocardial dysfunction induced by atrial pacing in XXXX .

answer: @entity235 :: (9615,Species) :: ['dogs']


abstract: BACKGROUND: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on @entity5 , @entity65 ( @entity65 ) and all-cause mortality, and most included @entity286 avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. METHODS: In 1992 and 1993, 111,966 nonsmoking @entity1 and @entity1 in the @entity5 Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American @entity5 Society @entity5 prevention guidelines on body mass index, physical activity, diet, and @entity167 consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of @entity204 and 95% CI were computed by Cox proportional hazard regression. RESULTS: During 14 years of follow-up, 10,369 @entity1 and 6,613 @entity1 died. The RR of all-cause mortality was lower for @entity1 with high (7, 8) versus low (0-2) scores ( @entity1 , RR = 0.58, 95% CI: 0.53-0.62; @entity1 , RR = 0.58, 95% CI: 0.52-0.64). Inverse associations were found with @entity65 mortality ( @entity1 , RR = 0.52, 95% CI: 0.45-0.59; @entity1 , RR = 0.42, 95% CI: 0.35-0.51) and @entity5 mortality ( @entity1 , RR = 0.70, 95% CI: 0.61-0.80; @entity1 , RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. CONCLUSION: Adherence to @entity5 prevention guidelines for @entity28 , diet, physical activity, and @entity167 consumption is associated with lower risk of @entity204 from @entity5 , @entity65 , and all causes in nonsmokers. IMPACT: Beyond @entity286 avoidance, following other @entity5 prevention guidelines may substantially lower risk of premature mortality in older adults.

title: Following @entity5 prevention guidelines reduces risk of @entity5 , XXXX , and all-cause mortality.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']


abstract: BACKGROUND: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on @entity5 , @entity65 ( @entity65 ) and all-cause mortality, and most included @entity286 avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. METHODS: In 1992 and 1993, 111,966 nonsmoking @entity1 and @entity1 in the @entity5 Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American @entity5 Society @entity5 prevention guidelines on body mass index, physical activity, diet, and @entity167 consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of @entity204 and 95% CI were computed by Cox proportional hazard regression. RESULTS: During 14 years of follow-up, 10,369 @entity1 and 6,613 @entity1 died. The RR of all-cause mortality was lower for @entity1 with high (7, 8) versus low (0-2) scores ( @entity1 , RR = 0.58, 95% CI: 0.53-0.62; @entity1 , RR = 0.58, 95% CI: 0.52-0.64). Inverse associations were found with @entity65 mortality ( @entity1 , RR = 0.52, 95% CI: 0.45-0.59; @entity1 , RR = 0.42, 95% CI: 0.35-0.51) and @entity5 mortality ( @entity1 , RR = 0.70, 95% CI: 0.61-0.80; @entity1 , RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. CONCLUSION: Adherence to @entity5 prevention guidelines for @entity28 , diet, physical activity, and @entity167 consumption is associated with lower risk of @entity204 from @entity5 , @entity65 , and all causes in nonsmokers. IMPACT: Beyond @entity286 avoidance, following other @entity5 prevention guidelines may substantially lower risk of premature mortality in older adults.

title: Following XXXX prevention guidelines reduces risk of @entity5 , @entity65 , and all-cause mortality.

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on @entity5 , @entity65 ( @entity65 ) and all-cause mortality, and most included @entity286 avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. METHODS: In 1992 and 1993, 111,966 nonsmoking @entity1 and @entity1 in the @entity5 Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American @entity5 Society @entity5 prevention guidelines on body mass index, physical activity, diet, and @entity167 consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of @entity204 and 95% CI were computed by Cox proportional hazard regression. RESULTS: During 14 years of follow-up, 10,369 @entity1 and 6,613 @entity1 died. The RR of all-cause mortality was lower for @entity1 with high (7, 8) versus low (0-2) scores ( @entity1 , RR = 0.58, 95% CI: 0.53-0.62; @entity1 , RR = 0.58, 95% CI: 0.52-0.64). Inverse associations were found with @entity65 mortality ( @entity1 , RR = 0.52, 95% CI: 0.45-0.59; @entity1 , RR = 0.42, 95% CI: 0.35-0.51) and @entity5 mortality ( @entity1 , RR = 0.70, 95% CI: 0.61-0.80; @entity1 , RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. CONCLUSION: Adherence to @entity5 prevention guidelines for @entity28 , diet, physical activity, and @entity167 consumption is associated with lower risk of @entity204 from @entity5 , @entity65 , and all causes in nonsmokers. IMPACT: Beyond @entity286 avoidance, following other @entity5 prevention guidelines may substantially lower risk of premature mortality in older adults.

title: Following @entity5 prevention guidelines reduces risk of XXXX , @entity65 , and all-cause mortality.

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: The ultraviolet (UV) region of solar radiation is a critical factor in the initiation and development of a number of @entity272 . However, it is not only skin which is directly exposed to solar light that is affected by UV radiation, through low molecular weight mediators, generated upon irradiation, "non-skin" tissues can also be affected. The aim of this study was to examine in detail, the acute effects of UVA and UVB wavebands on hairless @entity19 . Female SKH-1 hairless @entity19 were exposed to a single dose of UVB (200, 800 mJ/cm(2)) or UVA (10, 20 J/cm(2)) using a solar simulator. The effects on haematological parameters, activity and/or expression of antioxidant enzymes, level of @entity2041 ( @entity2197 ), markers of oxidative damage (lipid peroxidation and carbonylated proteins) were analysed in erythrocytes, plasma, liver and whole skin homogenates. No macroscopic changes were observed either 4 or 24 h after UVA/UVB exposure. The blood count showed a significant increase in leukocyte number and reduction of platelets 4 h following UVA and UVB irradiation, which disappeared 24 h after irradiation except for the higher UVA dose. Changes in oxidative stress-related parameters, particularly activity of catalase (CAT) and @entity224 dismutase (SOD) and level of @entity2197 and lipid peroxidation products, were found in skin, erythrocytes and liver. The expression of several enzymes (CAT, SOD, @entity2041 transferase (GST), @entity2125 ( @entity1391 ) @entity3276 oxidoreductase ( @entity26662 ) and hem oxygenase-1 (HO-1)) in skin was affected following UVA and UVB radiation. Increase in carbonylated proteins was found in plasma and skin samples.

title: Acute exposure to solar simulated ultraviolet radiation affects oxidative stress-related biomarkers in skin, liver and blood of hairless XXXX .

entities_list: @entity2125 :: ('MESH:D009243', 'Chemical') :: ['nicotinamide adenine dinucleotide']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin diseases']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

answer: @entity19 :: (10090,Species) :: ['mice']