abstract: OBJECTIVES: The purpose of this study was to evaluate the usefulness of MRI-guidance for core decompression of @entity2530 of the @entity2738 . MATERIALS AND METHODS: Twelve MRI-guided core decompressions were performed on @entity1 with different stages of @entity2530 of the @entity2738 . The @entity1 were asked to evaluate their @entity158 and their ability to function before and after the procedure and imaging findings were reviewed respectively. RESULTS: Technical success in reaching the target was 100  % without complications. Mean duration of the procedure itself was 54  min. All @entity1 with ARCO stage 1 @entity2530 experienced clinical benefit and pathological MRI findings were seen to diminish. @entity1 with more @entity1442 gained less, if any, benefit and total hip arthroplasty was eventually performed on four @entity1 . CONCLUSIONS: MRI-guidance seems technically feasible, accurate and safe for core decompression of @entity2530 of the @entity2738 . @entity1 with early stage @entity2530 may benefit from the procedure. KEY POINTS:     MRI is a useful guidance method for minimally invasive musculoskeletal interventions.     Bone drilling seems beneficial at early stages of @entity2530 .     MRI-guidance is safe and accurate for @entity79 .

title: MRI-guidance in percutaneous core decompression of XXXX of the @entity2738 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

answer: @entity2530 :: (MESH:D010020,Disease) :: ['osteonecrosis']


abstract: BACKGROUND AND PURPOSE: Mid-size sphincterotomy associated with @entity384 is an alternative to wide @entity9279 . However, which of the two techniques is most effective remains unclear. Hence, we conducted this study to compare both methods prospectively. METHOD: Since January 2012 until March 2014, 133 consecutive @entity1 with complex stones were included. Group A underwent mid-size sphincterotomy associated with @entity384 and group B underwent wide sphincterotomy alone. Success rates were assessed for: Extraction of stones, ductal patency rate, the use of mechanical lithotripsy, dose, time and dose per radioscopy area as well as procedure-related complications. RESULTS: Group A comprised 44 @entity1 and group B comprised 69 @entity1 . Overall success rate for extraction was 86.4% in group A and 70% in group B (p = 0.069). In @entity9279 , effective extraction was 89.3% in group A and 58.6% in group B (p = 0.019). Use of mechanical lithotripsy was 15.9% and 30.4%, respectively (p = 0.142). Total radiotherapy dose was 39.8 mGy vs. 26.2 mGy, respectively (p = 0.134). Complications occurred in 6.8% and 5.5% of the procedures in each group, without significant differences among them (p = 0.856). CONCLUSION: @entity384 is more effective and equally safe than conventional sphincterotomy for the management of giant main bile duct lithiasis.

title: XXXX versus sphincterotomy alone for the extraction of complex lithiasis: A prospective analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['large balloon dilation', 'Sphincterotomy plus large balloon dilation']

entities_list: @entity9279 :: ('MESH:D020347', 'Disease') :: ['giant lithiasis', 'sphincterotomy to remove complex lithiases']

answer: @entity384 :: (MESH:D002311,Disease) :: ['Sphincterotomy plus large balloon dilation']


abstract: BACKGROUND: Severe or prolonged stress can trigger @entity146 illnesses including mood and @entity148 . Recent work indicates that @entity19381 plays an important role in regulating stress effects. In rodents, exogenous @entity19381 administration can produce persistent elevations in the acoustic startle response, which may reflect @entity148 -like signs including hypervigilance. We investigated whether @entity19381 causes acute or persistent alterations in behaviors that reflect other core features of mood and @entity148 (motivation, social interaction, and attention). METHODS: Using male @entity35 , we examined if @entity19381 (.25-1.0   g, intracerebroventricular infusion) affects motivation as measured in the intracranial self-stimulation test. We also examined if @entity19381 alters interactions with a conspecific in the social interaction test. Finally, we examined if @entity19381 affects performance in the 5-choice serial reaction time task, which quantifies attention and error processing. RESULTS: Dose-dependent disruptions in motivation, social interaction, and attention were produced by @entity19381 , as reflected by increases in reward thresholds, decreases in social behaviors, and decreases in correct responses and alterations in posterror accuracy. Behavior normalized quickly in the intracranial self-stimulation and 5-choice serial reaction time task tests but remained dysregulated in the social interaction test. Effects on attention were attenuated by the corticotropin-releasing factor receptor-1 antagonist @entity31085 but not the k opioid receptor antagonist JDTic. CONCLUSIONS: Our findings suggest that @entity19381 affects numerous domains often dysregulated in mood and @entity148 , but that individual signs depend on brain substrates that are at least partially independent. This work may help to devise therapeutics that mitigate specific signs of these disorders.

title: Pituitary Adenylate Cyclase-Activating Polypeptide Disrupts Motivation, Social Interaction, and Attention in Male XXXX .

entities_list: @entity19381 :: ('24166(Tax:10116)', 'Gene') :: ['PACAP', 'pituitary adenylate cyclase-activating polypeptide (PACAP)']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'anxiety disorders']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity31085 :: ('MESH:C103016', 'Chemical') :: ['antalarmin']

answer: @entity35 :: (10116,Species) :: ['Sprague-Dawley Rats']


abstract: BACKGROUND: Sickle cell (SC) disease leading to @entity23984 induces skeletal changes in the form of @entity4421 , @entity1463 of femoral canal and @entity2530 of the femoral head. All these make @entity572 ( @entity572 ) difficult and prolonged. There is increased risk of @entity281 , SC crisis and increased complication rate. Our paper aims to highlight preoperative, intraoperative and postoperative hurdles encountered in performing @entity572 in sicklers and the short term outcome using cementless implants. MATERIALS AND METHODS: Thirty-nine @entity1 with @entity3458 , who had @entity2530 of the femoral head, were operated between 2007 and 2011. The mean age of @entity1 was 22 years (range 13-49 years). There were twenty eight females and 11 males. @entity572 (THR) was performed in 11 @entity1 (22 hips) and in the rest unilateral (28 hips). Preoperative and postoperative modified Harris hip score was evaluated. The average followup was 3.8 years (range 2-6 years). RESULTS: The average operating time was 96 min (range 88-148 min). The average @entity190 was 880 ml (range 650-1200 ml). The average intraoperative blood transfused was 2.3 units (range 2-5 units). All @entity1 showed an improvement in Harris hip score from 42 points preoperatively to 92 points at latest followup. Intraoperatively, one @entity1 had a @entity3564 . Six @entity1 developed @entity11511 and were managed in intensive care unit. Three @entity1 developed wound @entity1410 . Three @entity1 developed limb length discrepancy less than 1 cm. None had early or late dislocations, @entity281 , @entity2736 , @entity1930 and @entity1349 . CONCLUSION: @entity572 in sicklers involves considerable challenge for the orthopedic surgeon. Management requires a multidisciplinary approach involving the anesthetist, hematologist and the orthopedic surgeon. Contrary to previous reports, @entity572 in sicklers now has a predictable outcome especially with the use of cementless implants.

title: Short term results of XXXX in sicklers.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity23984 :: ('MESH:D004692', 'Disease') :: ['endarteritis']

entities_list: @entity3458 :: ('MESH:D000755', 'Disease') :: ['SC disease']

entities_list: @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'Bilateral cementless total hip replacement', 'total hip arthroplasty']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['aseptic loosening']

entities_list: @entity2736 :: ('MESH:D009999', 'Disease') :: ['heterotopic ossification']

entities_list: @entity11511 :: ('MESH:D054218', 'Disease') :: ['acute SC crisis']

entities_list: @entity1930 :: ('MESH:D020426', 'Disease') :: ['sciatic nerve palsy']

entities_list: @entity3564 :: ('MESH:D057068', 'Disease') :: ['periprosthetic fracture']

entities_list: @entity2530 :: ('MESH:D010020', 'Disease') :: ['osteonecrosis']

answer: @entity572 :: (MESH:D006617,Disease) :: ['cementless total hip arthroplasty']


abstract: PURPOSE: Long-term outcomes of @entity1 with T1 @entity14 ( @entity14 ) treated by endoscopic resection (ER) or surgical resection are unclear in relation to the curative criteria in the Japanese Society for @entity694 (JSCCR) guidelines. The aim of this study was to retrospectively compare the long-term outcomes among @entity1 with T1 @entity14 in relation to the treatment methods. METHODS: We examined 322 T1 @entity14 cases treated between January 1992 and August 2008 at Hiroshima University Hospital. @entity1 who did not meet the curative criteria in the JSCCR guidelines were defined as "non-endoscopically curable" and classified into three groups: underwent ER alone (group A: 45 @entity1 ), underwent additional surgery after ER (group B: 106 @entity1 ), and underwent surgical resection alone (group C: 92 @entity1 ). RESULTS: Of the 322 T1 @entity14 @entity1 , 79 were categorized as endoscopically curable and 243 as non-endoscopically curable. Among the endoscopically curable T1 @entity14 @entity1 , recurrence and 5-year @entity3012 rates were 0 and 94.2  %, respectively. In groups A, B, and C, recurrence rates were 4.4, 6.6, and 4.3  %, and @entity3012 rates were 85.6, 95.1, and 96.3  %, respectively (p   <   0.05). Local recurrence or distant/lymph node @entity3 was observed in 13 @entity1 (group A: 2; group B: 7; group C: 4). Death due to primary @entity14 occurred in six @entity1 (group B: 4; group C: 2). CONCLUSION: Long-term outcomes support the curative criteria according to the JSCCR guidelines. ER for T1 @entity14 did not worsen clinical outcomes in cases that required additional surgical resection.

title: Long-term outcomes after treatment for T1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal carcinoma']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['Cancer of the Colon and Rectum']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']


abstract: Fluorescein angiography was performed in 71 @entity1 at risk to develop Leber's @entity1781 (L.O.N.), in 10 females carriers of this disease and in 5 @entity1 during the acute phase. The examination was performed in three university eye clinics. The angiograms were randomly mixed with an equal number of 'controls' and reviewed in a blind fashion on two occasions by two observers. A scoring system was developed on the basis of the peripapillary microvascular changes known to occur in the acute phase of L.O.N. All 5 @entity1 could be recognised in this manner. In the pictures of one of the clinics, which were of good quality, a significant difference in scoring between the at risk and control groups appeared to exist. The results suggest that carriers also may have the same @entity941 angiographic abnormalities. One @entity1 from the at risk group who obtained high abnormal scores-identical to @entity1 in the acute phase-developed L.O.N. 6 months later.

title: Leber's XXXX II. @entity941 angiographic studies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'man', 'persons']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['Optic Neuropathy']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

answer: @entity1781 :: (MESH:D009901,Disease) :: ['optic neuropathy']


abstract: Fluorescein angiography was performed in 71 @entity1 at risk to develop Leber's @entity1781 (L.O.N.), in 10 females carriers of this disease and in 5 @entity1 during the acute phase. The examination was performed in three university eye clinics. The angiograms were randomly mixed with an equal number of 'controls' and reviewed in a blind fashion on two occasions by two observers. A scoring system was developed on the basis of the peripapillary microvascular changes known to occur in the acute phase of L.O.N. All 5 @entity1 could be recognised in this manner. In the pictures of one of the clinics, which were of good quality, a significant difference in scoring between the at risk and control groups appeared to exist. The results suggest that carriers also may have the same @entity941 angiographic abnormalities. One @entity1 from the at risk group who obtained high abnormal scores-identical to @entity1 in the acute phase-developed L.O.N. 6 months later.

title: Leber's @entity1781 II. XXXX angiographic studies.

answer: @entity941 :: (MESH:D019793,Chemical) :: ['Fluorescein']


abstract: AIM: The aim was to report the effectiveness and safety @entity9381 (Botox, Allergan, Inc., Irvine, CA, USA) intradetrusor injections in spinal cord-injured (SCI) @entity1 with refractory neurogenic detrusor overactivity. And to assess the result based on SCI level. MATERIALS AND METHODS: We reviewed the chart of 103 @entity1 with @entity1494 secondary to SCI at the rehab center who received @entity9381 in our Neurourology Department for treatment of lower urinary tract symptoms between January 2007 and December 2013. All @entity1 had a clinical examination, urinalysis, and an urodynamic study at baseline and 3 months after treatment as well as a visual analogue scale (VAS; range scale: 0-10) and a bladder diary checked for 3 days. 300 IU of @entity9381 , detrusor muscle injections were performed in 30 sites under cystoscopic guidance. Outcome measures included frequency of urge urinary @entity322 collected by bladder diaries; changes in urodynamic parameters such as maximum cystometric bladder capacity, reflex volume, maximum detrusor pressure; side-effects; antimuscarinic drug consumption and quality of life (QOL) measured with VAS. RESULTS: The study includes 32 female and 71 male with a mean @entity1 age of 29 years (range: 18-56 year). The effect of Botox injection on bladder function was observed within 1-2 week after treatment. The urodynamic parameters were improved significantly after treatment compared with baseline values. There were significant reductions in the frequencies of @entity322 episodes after treatment as seen in the voiding diary. A significant improvement in @entity1 satisfaction was found after treatment which was expressed on the VAS assessment, with an improvement of the mean of 3 points. @entity1 with @entity764 have better result compare to @entity130 @entity1 . The earliest recurrence of clinical symptoms was at 10 weeks. Overall, the mean duration of symptomatic improvement was 8 (2.5-21) months. CONCLUSION: Intradetrusor @entity9381 injections are an effective and well-tolerated treatment for @entity2182 that will increase @entity1 satisfaction and improve QOL with persisted clinical efficacy for more than 8 months.

title: The effect of spinal cord-injury level on the outcome of XXXX treatment using @entity9381 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['neurogenic bladder']

entities_list: @entity9381 :: ('MESH:C542870', 'Chemical') :: ['onabotulinumtoxinA', 'OnabotulinumtoxinA']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['thoracic and lumbar injury']

entities_list: @entity2182 :: ('MESH:D053201', 'Disease') :: ['neurogenic overactive bladder']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['cervical injury']

answer: @entity1494 :: (MESH:D001745,Disease) :: ['neurogenic bladder']


abstract: AIM: The aim was to report the effectiveness and safety @entity9381 (Botox, Allergan, Inc., Irvine, CA, USA) intradetrusor injections in spinal cord-injured (SCI) @entity1 with refractory neurogenic detrusor overactivity. And to assess the result based on SCI level. MATERIALS AND METHODS: We reviewed the chart of 103 @entity1 with @entity1494 secondary to SCI at the rehab center who received @entity9381 in our Neurourology Department for treatment of lower urinary tract symptoms between January 2007 and December 2013. All @entity1 had a clinical examination, urinalysis, and an urodynamic study at baseline and 3 months after treatment as well as a visual analogue scale (VAS; range scale: 0-10) and a bladder diary checked for 3 days. 300 IU of @entity9381 , detrusor muscle injections were performed in 30 sites under cystoscopic guidance. Outcome measures included frequency of urge urinary @entity322 collected by bladder diaries; changes in urodynamic parameters such as maximum cystometric bladder capacity, reflex volume, maximum detrusor pressure; side-effects; antimuscarinic drug consumption and quality of life (QOL) measured with VAS. RESULTS: The study includes 32 female and 71 male with a mean @entity1 age of 29 years (range: 18-56 year). The effect of Botox injection on bladder function was observed within 1-2 week after treatment. The urodynamic parameters were improved significantly after treatment compared with baseline values. There were significant reductions in the frequencies of @entity322 episodes after treatment as seen in the voiding diary. A significant improvement in @entity1 satisfaction was found after treatment which was expressed on the VAS assessment, with an improvement of the mean of 3 points. @entity1 with @entity764 have better result compare to @entity130 @entity1 . The earliest recurrence of clinical symptoms was at 10 weeks. Overall, the mean duration of symptomatic improvement was 8 (2.5-21) months. CONCLUSION: Intradetrusor @entity9381 injections are an effective and well-tolerated treatment for @entity2182 that will increase @entity1 satisfaction and improve QOL with persisted clinical efficacy for more than 8 months.

title: The effect of spinal cord-injury level on the outcome of @entity1494 treatment using XXXX .

answer: @entity9381 :: (MESH:C542870,Chemical) :: ['OnabotulinumtoxinA']


abstract: Cancers can be addicted to continued and relatively high expression of nuclear oncoproteins. This is evident in @entity14 ( @entity14 ) where the oncoprotein and transcription factor @entity17227 is over expressed and essential to continued proliferation and @entity5 cell survival. Historically, targeting transcription factors in the context of @entity5 has been very challenging. Nevertheless, we formulated a DNA vaccine to generate a @entity17227 -specific immune response in the belief @entity17227 peptides might be aberrantly presented on the cell surface of @entity14 cells. @entity17227 , like many @entity5 antigens, is weakly immunogenic as it is a 'self' antigen and is subject to tolerance. To break tolerance, a fusion vaccine was generated comprising a full-length @entity17227 complementary DNA (cDNA) flanked by two potent @entity1961 -epitopes derived from @entity116 toxoid. Vaccination was achieved against @entity5 initiated by two distinct highly aggressive, syngeneic @entity5 cell lines (CT26 and MC38) that express @entity17227 . This was done in BALB/c and C57BL/6 @entity19 strains respectively. We introduced multiple inactivating mutations into the oncogene sequence for safety and sub-cloned the cDNA into a Food and Drug Administration (FDA)-compliant vector. We used low dose @entity786 (CY) to overcome T-regulatory cell immune suppression, and anti-program cell death receptor 1 (anti- @entity1707 ) antibodies to block T-cell exhaustion. Anti-PD-1 administered alone slightly delayed @entity5 growth in MC38 and more effectively in CT26 bearing @entity19 , while CY treatment alone did not. We found that therapeutic vaccination elicits protection when MC38 @entity5 burden is low, mounts @entity5 -specific cell killing and affords enhanced protection when MC38 and CT26 @entity5 burden is higher but only in combination with anti-PD-1 antibody or low dose CY, respectively.

title: Therapeutic DNA vaccination against @entity14 by targeting the XXXX oncoprotein.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours', 'tumour']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

answer: @entity17227 :: (17863(Tax:10090),Gene) :: ['MYB']


abstract: Cancers can be addicted to continued and relatively high expression of nuclear oncoproteins. This is evident in @entity14 ( @entity14 ) where the oncoprotein and transcription factor @entity17227 is over expressed and essential to continued proliferation and @entity5 cell survival. Historically, targeting transcription factors in the context of @entity5 has been very challenging. Nevertheless, we formulated a DNA vaccine to generate a @entity17227 -specific immune response in the belief @entity17227 peptides might be aberrantly presented on the cell surface of @entity14 cells. @entity17227 , like many @entity5 antigens, is weakly immunogenic as it is a 'self' antigen and is subject to tolerance. To break tolerance, a fusion vaccine was generated comprising a full-length @entity17227 complementary DNA (cDNA) flanked by two potent @entity1961 -epitopes derived from @entity116 toxoid. Vaccination was achieved against @entity5 initiated by two distinct highly aggressive, syngeneic @entity5 cell lines (CT26 and MC38) that express @entity17227 . This was done in BALB/c and C57BL/6 @entity19 strains respectively. We introduced multiple inactivating mutations into the oncogene sequence for safety and sub-cloned the cDNA into a Food and Drug Administration (FDA)-compliant vector. We used low dose @entity786 (CY) to overcome T-regulatory cell immune suppression, and anti-program cell death receptor 1 (anti- @entity1707 ) antibodies to block T-cell exhaustion. Anti-PD-1 administered alone slightly delayed @entity5 growth in MC38 and more effectively in CT26 bearing @entity19 , while CY treatment alone did not. We found that therapeutic vaccination elicits protection when MC38 @entity5 burden is low, mounts @entity5 -specific cell killing and affords enhanced protection when MC38 and CT26 @entity5 burden is higher but only in combination with anti-PD-1 antibody or low dose CY, respectively.

title: Therapeutic DNA vaccination against XXXX by targeting the @entity17227 oncoprotein.

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: AIM: The aim of this study was to investigate the relationship between @entity28 and lower urinary tract symptoms and prostate volume in @entity1 who underwent prostate biopsies. MATERIALS AND METHODS: Between December 2008 and November 2009, transrectal ultrasound-guided prostate biopsy was performed on @entity1 who had elevated @entity1486 levels or abnormal digital rectal examination findings. A total of 211 @entity1 were included in this study. Prostate volumes, International Prostate Symptom Score (IPSS) values, and the @entity1 's height and weight were all recorded during the biopsy. Body mass index (BMI) <18.5 was determined as underweight, 18.5-23.0 normal, 23.0-27.5 overweight, and >27.5 @entity28 . RESULTS: The mean age of the @entity1 was 68.0    6.3 years, and the mean BMI was 28.0    4.9 kg/m(2). The mean prostate volume of the normal, overweight, and @entity28 groups was 30, 50, and 70 ml, respectively. The positive and statistically significant correlation between BMI and prostate volume was determined (P < 0.001). According to BMI, the mean IPSS was 8.0, 16.5, and 20.0 in the groups, respectively. Similarly, a statistically positive correlation between BMI and IPSS was demonstrated (P < 0.001). CONCLUSIONS: As the result of a rise in BMI, prostate volumes and IPSS increase in @entity1 . Prostate volume and IPSS decrease due to weight loss, and hence that fewer urinary symptoms occur, and the quality-of-life of @entity1 may increase.

title: Effect of XXXX on International Prostate Symptom Score and prostate volume.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: UNASSIGNED: In order to assess potential associations between @entity72 ( @entity72 ) phenotype, functional @entity74 and fecal microbiota, we recruited simplex families, which had only a single @entity72 proband and neurotypical (NT) siblings, through the Simons Simplex Community at the Interactive @entity2438 Network (SSC@IAN). Fecal samples and metadata related to functional @entity74 and diet were collected from @entity72 probands and NT siblings of @entity72 probands (age 7-14). @entity344 ( @entity344 ) were assessed using the parent-completed ROME III questionnaire for pediatric FGIDs, and problem behaviors were assessed using the @entity1 Behavior Check List (CBCL). Targeted quantitative polymerase chain reaction (qPCR) assays were conducted on selected taxa implicated in @entity72 , including Sutterella spp., Bacteroidetes spp. and Prevotella spp. Illumina sequencing of the V1V2 and the V1V3 regions of the bacterial 16S rRNA genes from fecal DNA was performed to an average depth of 208,000 and 107,000 high-quality reads respectively. Twenty-five of 59 @entity72 @entity1 and 13 of 44 NT siblings met ROME III criteria for at least one @entity344 . Functional @entity1142 was more prevalent in @entity72 (17 of 59) compared to NT siblings (6 of 44, P = 0.035). The mean CBCL scores in NT siblings with @entity344 , @entity72 @entity1 with @entity344 and @entity72 without @entity344 were comparably higher (58-62 vs. 44, P < 0.0001) when compared to NT @entity1 without @entity344 . There was no significant difference in macronutrient intake between @entity72 and NT siblings. There was no significant difference in @entity72 severity scores between @entity72 @entity1 with and without @entity344 . No significant difference in diversity or overall microbial composition was detected between @entity72 @entity1 with NT siblings. Exploratory analysis of the 16S rRNA sequencing data, however, identified several low abundance taxa binned at the genus level that were associated with @entity72 and/or first order @entity72 * @entity344 interactions (FDR <0.1).

title: Comparison of Fecal Microbiota in @entity1 with XXXX Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'children']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['FGID', 'Functional gastrointestinal disorders']

entities_list: @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorder']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['GI disorders']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

answer: @entity2438 :: (MESH:D001321,Disease) :: ['Autism']


abstract: UNASSIGNED: In order to assess potential associations between @entity72 ( @entity72 ) phenotype, functional @entity74 and fecal microbiota, we recruited simplex families, which had only a single @entity72 proband and neurotypical (NT) siblings, through the Simons Simplex Community at the Interactive @entity2438 Network (SSC@IAN). Fecal samples and metadata related to functional @entity74 and diet were collected from @entity72 probands and NT siblings of @entity72 probands (age 7-14). @entity344 ( @entity344 ) were assessed using the parent-completed ROME III questionnaire for pediatric FGIDs, and problem behaviors were assessed using the @entity1 Behavior Check List (CBCL). Targeted quantitative polymerase chain reaction (qPCR) assays were conducted on selected taxa implicated in @entity72 , including Sutterella spp., Bacteroidetes spp. and Prevotella spp. Illumina sequencing of the V1V2 and the V1V3 regions of the bacterial 16S rRNA genes from fecal DNA was performed to an average depth of 208,000 and 107,000 high-quality reads respectively. Twenty-five of 59 @entity72 @entity1 and 13 of 44 NT siblings met ROME III criteria for at least one @entity344 . Functional @entity1142 was more prevalent in @entity72 (17 of 59) compared to NT siblings (6 of 44, P = 0.035). The mean CBCL scores in NT siblings with @entity344 , @entity72 @entity1 with @entity344 and @entity72 without @entity344 were comparably higher (58-62 vs. 44, P < 0.0001) when compared to NT @entity1 without @entity344 . There was no significant difference in macronutrient intake between @entity72 and NT siblings. There was no significant difference in @entity72 severity scores between @entity72 @entity1 with and without @entity344 . No significant difference in diversity or overall microbial composition was detected between @entity72 @entity1 with NT siblings. Exploratory analysis of the 16S rRNA sequencing data, however, identified several low abundance taxa binned at the genus level that were associated with @entity72 and/or first order @entity72 * @entity344 interactions (FDR <0.1).

title: Comparison of Fecal Microbiota in XXXX with @entity2438 Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection.

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: OBJECTIVE: we performed a three-stages door-to-door survey to estimate incidence and prevalence of @entity302 associated with @entity410 seizures (EACS) in a rural area of Bolivia. METHODS: the study was carried out in the Cordillera Province, southern-eastern Bolivia. One hundred fourteen rural communities with a total population of 18,907 inhabitants were included in the survey. In order to identify subjects with EACS, trained fieldworkers administered a validated single screening question to the householders (stage I). A second face-to-face questionnaire was administered to each positive subject (stage II) that, in case of positive answer, underwent a complete neurological examination to confirm the diagnosis (stage III). We estimated age and sex specific life-time and active EACS prevalence at the prevalence day (30th June 2010). Incidence risk was evaluated for the 10-year period between January 2000 and December 2010. RESULTS: on prevalence day we identified 136 subjects with EACS, 124 of whom had active @entity302 . The life-time prevalence of EACS was 7.2/1,000 (7.6/1,000 age-adjusted to the world standard population) while the prevalence of active EACS was 6.6/1,000 (6.7/1,000 age-adjusted to the world standard population). Both life-time and active prevalence showed a peak (10.3/1,000) in the 15-24 years age group and, overall, were higher among @entity1 . During the incidence study period, 105 @entity1 living in the study area had the onset of EACS. The crude incidence risk was 55.4/100,000 (49.5/100,000 age-adjusted to the world standard population). Incidence was slightly but not significantly higher among @entity1 (58.9/100,000 versus 51.9/100,000). CONCLUSIONS: the present study demonstrated a considerable burden of EACS in the Bolivian Chaco, showing prevalence and incidence estimates close to those reported for low and middle- income countries and underlying the need of treatment programs.

title: Prevalence and Incidence of @entity302 Associated with XXXX . A Global Campaign against @entity302 Project.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsive']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

answer: @entity410 :: (MESH:D012640,Disease) :: ['Convulsive Seizures in Rural Bolivia']


abstract: OBJECTIVE: we performed a three-stages door-to-door survey to estimate incidence and prevalence of @entity302 associated with @entity410 seizures (EACS) in a rural area of Bolivia. METHODS: the study was carried out in the Cordillera Province, southern-eastern Bolivia. One hundred fourteen rural communities with a total population of 18,907 inhabitants were included in the survey. In order to identify subjects with EACS, trained fieldworkers administered a validated single screening question to the householders (stage I). A second face-to-face questionnaire was administered to each positive subject (stage II) that, in case of positive answer, underwent a complete neurological examination to confirm the diagnosis (stage III). We estimated age and sex specific life-time and active EACS prevalence at the prevalence day (30th June 2010). Incidence risk was evaluated for the 10-year period between January 2000 and December 2010. RESULTS: on prevalence day we identified 136 subjects with EACS, 124 of whom had active @entity302 . The life-time prevalence of EACS was 7.2/1,000 (7.6/1,000 age-adjusted to the world standard population) while the prevalence of active EACS was 6.6/1,000 (6.7/1,000 age-adjusted to the world standard population). Both life-time and active prevalence showed a peak (10.3/1,000) in the 15-24 years age group and, overall, were higher among @entity1 . During the incidence study period, 105 @entity1 living in the study area had the onset of EACS. The crude incidence risk was 55.4/100,000 (49.5/100,000 age-adjusted to the world standard population). Incidence was slightly but not significantly higher among @entity1 (58.9/100,000 versus 51.9/100,000). CONCLUSIONS: the present study demonstrated a considerable burden of EACS in the Bolivian Chaco, showing prevalence and incidence estimates close to those reported for low and middle- income countries and underlying the need of treatment programs.

title: Prevalence and Incidence of XXXX Associated with @entity410 . A Global Campaign against @entity302 Project.

answer: @entity302 :: (MESH:D004827,Disease) :: ['Epilepsy']


abstract: OBJECTIVE: we performed a three-stages door-to-door survey to estimate incidence and prevalence of @entity302 associated with @entity410 seizures (EACS) in a rural area of Bolivia. METHODS: the study was carried out in the Cordillera Province, southern-eastern Bolivia. One hundred fourteen rural communities with a total population of 18,907 inhabitants were included in the survey. In order to identify subjects with EACS, trained fieldworkers administered a validated single screening question to the householders (stage I). A second face-to-face questionnaire was administered to each positive subject (stage II) that, in case of positive answer, underwent a complete neurological examination to confirm the diagnosis (stage III). We estimated age and sex specific life-time and active EACS prevalence at the prevalence day (30th June 2010). Incidence risk was evaluated for the 10-year period between January 2000 and December 2010. RESULTS: on prevalence day we identified 136 subjects with EACS, 124 of whom had active @entity302 . The life-time prevalence of EACS was 7.2/1,000 (7.6/1,000 age-adjusted to the world standard population) while the prevalence of active EACS was 6.6/1,000 (6.7/1,000 age-adjusted to the world standard population). Both life-time and active prevalence showed a peak (10.3/1,000) in the 15-24 years age group and, overall, were higher among @entity1 . During the incidence study period, 105 @entity1 living in the study area had the onset of EACS. The crude incidence risk was 55.4/100,000 (49.5/100,000 age-adjusted to the world standard population). Incidence was slightly but not significantly higher among @entity1 (58.9/100,000 versus 51.9/100,000). CONCLUSIONS: the present study demonstrated a considerable burden of EACS in the Bolivian Chaco, showing prevalence and incidence estimates close to those reported for low and middle- income countries and underlying the need of treatment programs.

title: Prevalence and Incidence of @entity302 Associated with @entity410 . A Global Campaign against XXXX Project.

answer: @entity302 :: (MESH:D004827,Disease) :: ['Epilepsy']


abstract: Traditional histopathological diagnosis of @entity0 has been extended in recent years through the results of additional methods. Today, the results of the detection of hormone receptors, @entity1722 , and Ki67 antigen are thus an integral part of the histopathological diagnosis. A critical factor for the success of these tests is the fulfillment of pre-analytical phase conditions - i.e. optimal fixation, as well as taking into account the heterogeneous nature of the neoplastic population. In addition to the above-mentioned markers - which have become a routine practice in recent years, there are many efforts to include the molecular characteristics of @entity5 both in @entity5 classification as well as in the prediction of results of @entity5 treatment. Most of the work is based on the use of gene expression profiles. On the basis of the detection of increased or decreased expression of a large number of genes, it is possible to find a set of multiple genes correlating with the biological behavior of the @entity5 . Using this approach, four basic subgroups of @entity0 have been identified - luminal, basal-like, @entity1722 enriched and normal gland-like. Over the course of time, the number of molecular categories has expanded - originally a homogenous group of @entity5 has been subclassified into the luminal A, B and C. @entity1491 additional subgroups have been identified. However, the results of studies dealing with the analysis of gene expression profiles suggest that our understanding of the biology of @entity0 is far from being complete. The individual categories are defined differently in various publications and thus the comparison of the results of these studies is very difficult. Another approach for the molecular classification of @entity0 is the immunohistochemical detection of various proteins used as a surrogate marker instead of the detection of the mRNA of individual genes. The advantage of this approach is the possibility to use even archive material, as well as much lower costs. On the other hand, its main limitation is the inability of parallel detection of thousands of markers, unlike in genomic profiling. The results of molecular classification are, however, not fundamentally surprising. The fact that @entity0 stem cells can differentiate towards myoepithelial (or basal) and luminal cells has been known for a long time. These two lines of differentiation are - among others - characterized by differential expression of cytoskeletal proteins as well as of other molecules. These findings have been confirmed by the results of molecular studies - either those based on gene expression profiling or immunohistochemical ones. Research results in gene expression profiling have relatively quickly translated into clinical practice. At present, several commercially available certified tests serve as a complementary source of information for decisions about clinical treatment.

title: [Hopes and pitfalls of the molecular classification of XXXX ].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'luminal cancers', 'cancer', 'tumors']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast cancer tumor']

entities_list: @entity1491 :: ('MESH:D002280', 'Disease') :: ['Also within basal-like carcinomas']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: Drugs used to treat @entity716 may take weeks to be effective. In the interim, additional 'as required' doses of medication can be used to calm @entity1 in @entity146 wards. The practice is widespread, with 20% to 50% of @entity1 on acute @entity146 wards receiving at least one 'as required' dose of psychotropic medication during their admission. OBJECTIVES: To compare the effects of 'as required' medication regimens with regular patterns of medication for the treatment of @entity716 or behavioural disturbance, thought to be secondary to @entity716 . These regimens may be given alone or in addition to any regular psychotropic medication for the long-term treatment of @entity161 or @entity161 -like illnesses. SEARCH METHODS: We searched the Cochrane @entity161 Group's Trials Register, which is based on regular searches of MEDLINE, EMBASE, PubMed, CINAHL, BIOSIS, AMED, PsycINFO and registries of clinical trials, in November 2001, March 2006, July 2012 andOctober 2013. SELECTION CRITERIA: We aimed to include all relevant randomised controlled trials involving hospital inpatients with @entity161 or @entity161 -like illnesses, comparing any regimen of medication administered for the short-term relief of behavioural disturbance, or @entity716 , to be given at the discretion of ward staff ('as required', 'prn') with fixed non-discretionary patterns of drug administration of the same drug(s). This was in addition to regular psychotropic medication for the long-term treatment of @entity161 or @entity161 -like illnesses where prescribed. DATA COLLECTION AND ANALYSIS: We independently inspected abstracts and papers for inclusion. If trials had been found, we would have extracted data from the papers and quality assessed the data. For dichotomous data we would have calculated the risk ratios (RR), with the 95% confidence intervals (CI). We would have conducted analyses on an intention-to-treat basis. If data were available we would have completed a 'Summary of findings' table using GRADE. MAIN RESULTS: We have not been able to identify any randomised trials comparing 'as required' medication regimens to regular regimens of the same drug. Our main outcomes of interest were important changes in (i) mental state, (ii) behaviour, (iii) dose of medication used, (iv) adverse events, (v) satisfaction with care and (iv) cost of care. AUTHORS' CONCLUSIONS: There is currently no evidence from within randomised trials to support this common practice. Current practice is based on clinical experience and habit rather than high quality evidence.

title: 'As required' medication regimens for seriously mentally ill XXXX in hospital.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic illness', 'psychotic illnesses', 'psychotic symptoms']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: IMPORTANCE: After @entity15 ( @entity15 ) relapse while a @entity1 is receiving an injectable disease-modifying drug, many physicians advocate therapy switch, but the relative effectiveness of different switch decisions is often uncertain. OBJECTIVE: To compare the effect of the oral immunomodulator fingolimod with that of all injectable immunomodulators (interferons or @entity1638 ) on relapse rate, disability, and treatment persistence in @entity1 with active @entity15 . DESIGN, SETTING, AND @entity1 : Matched retrospective analysis of data collected prospectively from MSBase, an international, observational cohort study. The MSBase cohort represents a population of @entity1 with @entity15 monitored at large @entity15 centers. The analyzed data were collected between July 1996 and April 2014. @entity1 included @entity1 with relapsing-remitting @entity15 who were switching therapy to fingolimod or injectable immunomodulators up to 12 months after on-treatment clinical disease activity (relapse or @entity717 ), matched on demographic and clinical variables. Median follow-up duration was 13.1 months (range, 3-80). Indication and attrition bias were controlled with propensity score matching and pairwise censoring, respectively. Head-to-head analyses of relapse and disability outcomes used paired, weighted, negative binomial models or frailty proportional hazards models adjusted for magnetic resonance imaging variables. Sensitivity analyses were conducted. EXPOSURES: @entity1 had received fingolimod, interferon beta, or @entity1638 for a minimum of 3 months following a switch of immunomodulatory therapy. MAIN OUTCOMES AND MEASURES: Annualized relapse rate and proportion of relapse-free @entity1 , as well as the proportion of @entity1 without sustained disability progression. RESULTS: Overall, 379 @entity1 in the injectable group were matched to 148 @entity1 in the fingolimod group. The fingolimod group had a lower mean annualized relapse rate (0.31 vs 0.42; 95% CI, 0.02-0.19; P=.009), lower hazard of first on-treatment relapse (hazard ratio [HR], 0.74; 95% CI, 0.56-0.98; P=.04), lower hazard of disability progression (HR, 0.53; 95% CI, 0.31-0.91; P=.02), higher rate of disability regression (HR, 2.0; 95% CI, 1.2-3.3; P=.005), and lower hazard of treatment discontinuation (HR, 0.55; P=.04) compared with the injectable group. CONCLUSIONS AND RELEVANCE: Switching from injectable immunomodulators to fingolimod is associated with fewer relapses, more favorable disability outcomes, and greater treatment persistence compared with switching to another injectable preparation following on-treatment activity of @entity15 .

title: Comparison of switch to fingolimod or interferon beta/ @entity1638 in active XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Participants', 'PARTICIPANTS']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['progression of disability']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']

entities_list: @entity1638 :: ('MESH:C089995', 'Chemical') :: ['glatiramer acetate']

answer: @entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']


abstract: IMPORTANCE: After @entity15 ( @entity15 ) relapse while a @entity1 is receiving an injectable disease-modifying drug, many physicians advocate therapy switch, but the relative effectiveness of different switch decisions is often uncertain. OBJECTIVE: To compare the effect of the oral immunomodulator fingolimod with that of all injectable immunomodulators (interferons or @entity1638 ) on relapse rate, disability, and treatment persistence in @entity1 with active @entity15 . DESIGN, SETTING, AND @entity1 : Matched retrospective analysis of data collected prospectively from MSBase, an international, observational cohort study. The MSBase cohort represents a population of @entity1 with @entity15 monitored at large @entity15 centers. The analyzed data were collected between July 1996 and April 2014. @entity1 included @entity1 with relapsing-remitting @entity15 who were switching therapy to fingolimod or injectable immunomodulators up to 12 months after on-treatment clinical disease activity (relapse or @entity717 ), matched on demographic and clinical variables. Median follow-up duration was 13.1 months (range, 3-80). Indication and attrition bias were controlled with propensity score matching and pairwise censoring, respectively. Head-to-head analyses of relapse and disability outcomes used paired, weighted, negative binomial models or frailty proportional hazards models adjusted for magnetic resonance imaging variables. Sensitivity analyses were conducted. EXPOSURES: @entity1 had received fingolimod, interferon beta, or @entity1638 for a minimum of 3 months following a switch of immunomodulatory therapy. MAIN OUTCOMES AND MEASURES: Annualized relapse rate and proportion of relapse-free @entity1 , as well as the proportion of @entity1 without sustained disability progression. RESULTS: Overall, 379 @entity1 in the injectable group were matched to 148 @entity1 in the fingolimod group. The fingolimod group had a lower mean annualized relapse rate (0.31 vs 0.42; 95% CI, 0.02-0.19; P=.009), lower hazard of first on-treatment relapse (hazard ratio [HR], 0.74; 95% CI, 0.56-0.98; P=.04), lower hazard of disability progression (HR, 0.53; 95% CI, 0.31-0.91; P=.02), higher rate of disability regression (HR, 2.0; 95% CI, 1.2-3.3; P=.005), and lower hazard of treatment discontinuation (HR, 0.55; P=.04) compared with the injectable group. CONCLUSIONS AND RELEVANCE: Switching from injectable immunomodulators to fingolimod is associated with fewer relapses, more favorable disability outcomes, and greater treatment persistence compared with switching to another injectable preparation following on-treatment activity of @entity15 .

title: Comparison of switch to fingolimod or interferon beta/ XXXX in active @entity15 .

answer: @entity1638 :: (MESH:C089995,Chemical) :: ['glatiramer acetate']


abstract: OBJECTIVE: To evaluate the efficiency of using a continuous (one-step) protocol with a single medium for the culture of @entity1 embryos in a @entity1054 ( @entity1054 ). DESIGN: Prospective cohort study on sibling donor oocytes. SETTING: University-affiliated @entity52 ( @entity52 ) center. @entity1 (S): Embryos from 59 @entity1 . INTERVENTION(S): Culture in a @entity1054 in a single medium with or without renewal of the medium on day-3. MAIN OUTCOME MEASURE(S): Embryo morphology and morphokinetic parameters, clinical pregnancy, take-home baby rate, and perinatal outcomes. RESULT(S): The blastocyst rates (68.3 vs. 66.8%) and the proportion of @entity2085 (transferred plus frozen) obtained with the two-step (80.0%) protocol were statistically significantly similar to those obtained in the one-step protocol (72.2%). Similarly, morphokinetic events from early cleavage until late blastocyst stages were statistically significantly equivalent between both groups. No differences were found either in clinical pregnancy rates when comparing pure transfers performed with embryos selected from the two-step (75.0%), one-step (70.0%, respectively), and mixed (57.1%) groups. A total of 55 out of 91 embryos transferred implanted successfully (60.4%), resulting in a total of 37 newborns with a comparable birth weight mean among groups. CONCLUSION(S): Our findings support the idea that in a @entity1054 with a controlled air purification system, @entity1 embryos can be successfully cultured continuously from day 0 onward in single medium with no need to renew it on day-3. This strategy does not affect embryo morphokinetics or development to term and offers more stable culture conditions for embryos as well as practical advantages and reduced costs for the @entity52 laboratory.

title: Blastocyst development in single medium with or without renewal on  day 3: a prospective cohort study on sibling donor oocytes in a XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PATIENT']

entities_list: @entity2085 :: ('MESH:D020964', 'Disease') :: ['good-quality blastocysts']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['time-lapse incubator', 'TLI']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in  vitro fertilization']

answer: @entity1054 :: (MESH:D000377,Disease) :: ['time-lapse incubator']


abstract: OBJECTIVE: Evaluate effect of pelvic floor muscle training (PFMT) on vaginal symptoms and @entity458 , @entity546 and @entity322 in primiparous @entity1 stratified by major or no defects of the levator ani muscle. DESIGN: Randomised controlled trial (RCT). SETTING: Akershus University Hospital, Norway. SAMPLE: About 175 primiparous @entity1 with a singleton vaginal delivery. METHODS: Two-armed assessor blinded parallel group RCT from 6 weeks to 6 months postpartum comparing effect of PFMT versus control. MAIN OUTCOME MEASURES: International Consultation on Incontinence Modular Questionnaire-vaginal symptoms questionnaire (ICIQ-VS) and ICIQ @entity458 module (ICIQ-FLUTSsex). RESULTS: Overall, analysis (n = 175) showed no difference between training and control groups in @entity1 having vaginal symptoms or symptoms related to @entity250 6 months postpartum. The majority of @entity1 (88%) had intercourse and there was no difference between groups. Unadjusted subgroup analysis of @entity1 with a major defect of the levator ani muscle (n = 55) showed that @entity1 in the training group had 45% less risk of having the symptom 'vagina feels loose or lax' compared with the control group (relative risk 0.55, 95% confidence interval 0.31, 0.95; P = 0.03). CONCLUSIONS: Unadjusted analysis showed that in @entity1 with major defect of the levator ani muscle, significantly fewer in the training group had the symptom 'vagina feels loose or lax' compared with the control group. No difference was found between groups for symptoms related to @entity250 . More studies are needed to explore effect of PFMT on vaginal symptoms and @entity250 . TWEETABLE ABSTRACT: Unadjusted analysis shows that PFMT might prevent symptoms of 'vagina feels loose or lax'.

title: Effect of postpartum pelvic floor muscle training on vaginal symptoms and XXXX -secondary analysis of a randomised trial.

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['coital incontinence']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual matters']

entities_list: @entity546 :: ('MESH:D004414', 'Disease') :: ['dyspareunia']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity250 :: (MESH:D012735,Disease) :: ['sexual dysfunction']


abstract: UNASSIGNED: Pathogenic and non-pathogenic fungi synthesize glycosphingolipids, which have a crucial role in growth and viability. Glycosphingolipids also contribute to fungal-associated pathogenesis. The opportunistic @entity375 pathogen @entity5132 synthesizes phospholipomannan (PLM), which is a glycosphingolipid of the @entity71566 family. Through its lipid and glycan moieties, PLM contributes to the initial recognition of the @entity375 , causing @entity1200 and persistent @entity364 through activation of host signaling pathways. The lipid moiety of PLM activates the deregulation signaling pathway involved in @entity375 phagocytosis whereas its glycan moiety, composed of b-1,2 @entity71567 (b- @entity1 ), participates to inflammatory processes through a mechanism involving Galectin-3. Biosynthesis of PLM b- @entity1 involves two b-1,2 mannosyltransferases (Bmts) that initiate ( @entity71568 ) and elongate (Bmt6) the glycan chains. After generation of double bmts   mutants, we show that @entity71568 has redundant activity with @entity71569 , which can replace @entity71568 in @entity71568   mutant. We also report that PLM is located in the inner layer of the @entity375 cell wall. PLM seems to be not essential for @entity281 of the @entity375 . However, defect of PLM b-mannosylation increases resistance of @entity5132 to inhibitors of b-glucans and chitin synthesis, highlighting a role of PLM in cell wall homeostasis.

title: Initiation of phospholipomannan b-1,2 mannosylation involves Bmts with redundant activity, influences its cell wall location and regulates b-glucans homeostasis but is dispensable for @entity5132 XXXX .

entities_list: @entity71567 :: ('MESH:D008362', 'Chemical') :: ['mannosides']

entities_list: @entity71566 :: ('MESH:C479822', 'Chemical') :: ['mannosylinositol phosphorylceramide']

entities_list: @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C.  albicans']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['systemic infection']

entities_list: @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune system disorder']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal disease']

answer: @entity281 :: (MESH:D007239,Disease) :: ['systemic infection']


abstract: UNASSIGNED: Pathogenic and non-pathogenic fungi synthesize glycosphingolipids, which have a crucial role in growth and viability. Glycosphingolipids also contribute to fungal-associated pathogenesis. The opportunistic @entity375 pathogen @entity5132 synthesizes phospholipomannan (PLM), which is a glycosphingolipid of the @entity71566 family. Through its lipid and glycan moieties, PLM contributes to the initial recognition of the @entity375 , causing @entity1200 and persistent @entity364 through activation of host signaling pathways. The lipid moiety of PLM activates the deregulation signaling pathway involved in @entity375 phagocytosis whereas its glycan moiety, composed of b-1,2 @entity71567 (b- @entity1 ), participates to inflammatory processes through a mechanism involving Galectin-3. Biosynthesis of PLM b- @entity1 involves two b-1,2 mannosyltransferases (Bmts) that initiate ( @entity71568 ) and elongate (Bmt6) the glycan chains. After generation of double bmts   mutants, we show that @entity71568 has redundant activity with @entity71569 , which can replace @entity71568 in @entity71568   mutant. We also report that PLM is located in the inner layer of the @entity375 cell wall. PLM seems to be not essential for @entity281 of the @entity375 . However, defect of PLM b-mannosylation increases resistance of @entity5132 to inhibitors of b-glucans and chitin synthesis, highlighting a role of PLM in cell wall homeostasis.

title: Initiation of phospholipomannan b-1,2 mannosylation involves Bmts with redundant activity, influences its cell wall location and regulates b-glucans homeostasis but is dispensable for XXXX @entity281 .

answer: @entity5132 :: (5476,Species) :: ['Candida albicans']


abstract: OBJECTIVE: This study aims to examine the prevalence and diameter of the bony canal structure of the @entity1416 ( @entity1416 ), @entity604 height, and distance of its inferior border from the alveolar crest using cone-beam computed tomography (CBCT). METHODS: CBCT images of maxilla in 116 @entity1 were randomly selected from @entity1 who underwent maxillary sinus augmentation procedure and/or posterior teeth implant therapy from April 2011 to September 2012. The lower border of the bony canal to the alveolar crest, diameter of the bony canal, and @entity604 height below the sinus floor to the ridge crest were measured from CBCT scans. Data were presented using descriptive statistics. RESULTS: The prevalence of the bony canal was 75.14% (133/177). The mean diameter of the bony canal was (0.96    0.29) mm. The @entity604 height was (7.14    3.64) mm. The distance of the bony canal's inferior border from the alveolar crest was (17.92    5.68) mm. No statistically significant differences between the right and left sides were observed (F = 0.295, P > 0.05). The mean diameter of the bony canal was significantly smaller in females than that in males (F = 0.187, P < 0.05). The maxillary alveolar dimension was significantly correlated with the @entity604 height. CONCLUSION: The results from this study suggest that CBCT is a valuable tool in evaluating the presence of the bony canal of the PSAAs efore maxillary sinus surgery.

title: [Evaluating the bony canal structure of the XXXX using cone-beam computed tomography].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['residual alveolar bone']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['posterior superior alveolar artery', 'PSAA']

answer: @entity1416 :: (MESH:D020762,Disease) :: ['posterior superior alveolar artery']


abstract: OBJECTIVE: To evaluate the clinical and radiographic characteristics of @entity165 @entity738 of the petrous apex, as well as the outcomes of operative and conservative management. STUDY DESIGN: Retrospective chart review. SETTING: Two independent tertiary academic referral centers. @entity1 : Adult and pediatric @entity1 with @entity165 @entity738 of the petrous apex were identified from the experience of two separate centers. @entity1 were included after radiographic diagnosis and clinical evaluation. All @entity1 with less than 6 months of follow-up and those with iatrogenic postoperative @entity165 @entity738 were excluded. INTERVENTION: Demographic information, presenting symptoms, imaging characteristics, treatment strategies, and outcomes were recorded. MAIN OUTCOME MEASURES: @entity1 were evaluated on the basis of symptom and radiographic evolution during time, with or without operative intervention. RESULTS: Ninety petrous apex @entity165 @entity738 were analyzed (57.8% females, 55.6% right-sided). The average age at presentation was 43.1 years (median 42.0, range 8.0-77.0 years). The most common presenting symptom was @entity10 (56.7%), and the average lesion size in the greatest dimension was 2.1cm (median 1.7, range 0.7-5.0cm). During a mean follow-up of 46.0 months, no cases of spontaneous @entity397 or @entity130 occurred. Twenty-three @entity1 (25.6%) ultimately underwent surgical management, most commonly for intractable @entity10 , and only 47.8% of these @entity1 experienced durable symptom improvement by their last postoperative follow-up. CONCLUSION: Many @entity165 @entity738 of the petrous apex remain stable during time and can be safely managed with primary observation. Surgery should be reserved for lesions that are causing, or threatening, @entity51 because of mass effect or erosion of critical structures such as the otic capsule. @entity129 associated with @entity165 @entity738 may improve after operative management; however, symptoms such as @entity10 and @entity1296 are less likely to benefit from surgery. As a general guideline, in the presence of a radiologically stable @entity165 @entity738 in the petrous apex, alternative etiologies for @entity10 and @entity1296 should be considered and treated before offering surgical intervention.

title: The Natural History and Management of Petrous Apex @entity165 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['Cranial neuropathy']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas', 'granuloma']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['carotid injury']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic dysfunction']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity738 :: (MESH:D006099,Disease) :: ['Granulomas']


abstract: OBJECTIVE: To evaluate the clinical and radiographic characteristics of @entity165 @entity738 of the petrous apex, as well as the outcomes of operative and conservative management. STUDY DESIGN: Retrospective chart review. SETTING: Two independent tertiary academic referral centers. @entity1 : Adult and pediatric @entity1 with @entity165 @entity738 of the petrous apex were identified from the experience of two separate centers. @entity1 were included after radiographic diagnosis and clinical evaluation. All @entity1 with less than 6 months of follow-up and those with iatrogenic postoperative @entity165 @entity738 were excluded. INTERVENTION: Demographic information, presenting symptoms, imaging characteristics, treatment strategies, and outcomes were recorded. MAIN OUTCOME MEASURES: @entity1 were evaluated on the basis of symptom and radiographic evolution during time, with or without operative intervention. RESULTS: Ninety petrous apex @entity165 @entity738 were analyzed (57.8% females, 55.6% right-sided). The average age at presentation was 43.1 years (median 42.0, range 8.0-77.0 years). The most common presenting symptom was @entity10 (56.7%), and the average lesion size in the greatest dimension was 2.1cm (median 1.7, range 0.7-5.0cm). During a mean follow-up of 46.0 months, no cases of spontaneous @entity397 or @entity130 occurred. Twenty-three @entity1 (25.6%) ultimately underwent surgical management, most commonly for intractable @entity10 , and only 47.8% of these @entity1 experienced durable symptom improvement by their last postoperative follow-up. CONCLUSION: Many @entity165 @entity738 of the petrous apex remain stable during time and can be safely managed with primary observation. Surgery should be reserved for lesions that are causing, or threatening, @entity51 because of mass effect or erosion of critical structures such as the otic capsule. @entity129 associated with @entity165 @entity738 may improve after operative management; however, symptoms such as @entity10 and @entity1296 are less likely to benefit from surgery. As a general guideline, in the presence of a radiologically stable @entity165 @entity738 in the petrous apex, alternative etiologies for @entity10 and @entity1296 should be considered and treated before offering surgical intervention.

title: The Natural History and Management of Petrous Apex XXXX @entity738 .

answer: @entity165 :: (MESH:D002784,Chemical) :: ['Cholesterol']


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Daouri, a combination of several plants, is an old African Traditional Medicine based on ancestral knowledge transmitted from generation to generation and is used by the Kotokoli Community in Togo. The combination of several plants may potentiate or attenuate the @entity137 of individual plants. The present investigation aims to study the composition and potential @entity137 of Daouri used in @entity1 in the Kotokoli community. MATERIALS AND METHODS: Surveys were performed using a semi-structured questionnaire to determine the composition of Daouri. On the basis of these data collected, Standard Daouri was formulated, and its aqueous extract was orally administered at 300, 600 and 1200mg/kg to @entity35 for 28 days. On the 29th day, the @entity35 were sacrificed and their serum were analysed to evaluate @entity99 . RESULTS: Four categories of Daouri were collected. The plant combinations used in each Daouri formulation varied according to the pathological conditions, including the age of the @entity1 and the availability of each plant. The most plants cited in the four Daouri were Khaya senegalensis (Desv.) A. Juss, Odina acida (A. Rich.) Oliv.,Lophira lanceolata Tiegh, Paullinia pinnata L. and Pteleopsis suberosa Engl. _ Diels. Although there was an increase in the alkaline phosphatase concentration, different doses of the aqueous extract of Standard Daouri were not toxic after 28 days of administration. In addition, the concentrations of @entity493 transaminase, @entity1011 and @entity1133 were not different between the Daouri-treated and control groups. CONCLUSION: Daouri is plant combination used in @entity1 in the Kotokoli community as a part of African Traditional Medicine. Standard Daouri is not toxic in @entity35 .

title: Toxicological screening of Daouri, a polyherbal formulation used in XXXX in the Central Region of Togo.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic and renal toxicities']

entities_list: @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: AIM: To test the efficacy of lay open (deroofing, not excision) with curettage under local anesthesia (LOCULA) for @entity2869 as an outpatient procedure. METHODS: LOCULA procedure was done for all types of @entity66 . The primary outcome measure was cure rate. The secondary outcome measures were hospital stay, operating time, return to work, healing time and complication rate. RESULTS: Thirty-three (M/ @entity16963 , mean age-23.4    5.8 years) consecutive @entity1 were operated and followed for 24 mo (6-46 mo). Eleven were @entity2869 and 22 were chronic @entity66 . Six had recurrent disease. Operating time and the hospital stay was 22.3    5.6 min and 63.8    22.3 min respectively. The @entity1 could resume normal work in 4.3    3.2 d and the healing time was 42.9    8.1 d. Thirty (93.8%) @entity1 had complete resolution of the disease and two (6.2%) had a recurrence. Both the recurrences happened in @entity1 who had complete healing but ignored the prescribed recommendations. One out of these got cured after getting operated again with the same procedure. Thus the overall success rate of this procedure was 96.9%. CONCLUSION: Lay open (deroofing) with curettage procedure under local anesthesia is an effective procedure to treat both simple and complicated @entity2869 . It is a simple procedure, has a high cure rate (up to 97%), doesn't require admission and is associated with minimal morbidity and scarring. Considering the distinct advantages, this procedure has the potential to become the first line procedure for treating @entity66 .

title: Laying open (deroofing) and curettage under local anesthesia for XXXX : An outpatient procedure.

entities_list: @entity2869 :: ('MESH:D010864', 'Disease') :: ['pilonidal sinus and abscess', 'pilonidal abscess', 'pilonidal sinus']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['pilonidal disease']

answer: @entity66 :: (MESH:D004194,Disease) :: ['pilonidal disease']


abstract: OBJECTIVE: To compare the efficacy and tolerance of adjuvant chemotherapy and radiotherapy delivered in sequential (chemotherapy followed by radiation) versus "sandwich" fashion (chemotherapy, interval radiation, and remaining chemotherapy) after surgery in @entity1 with FIGO stage III uterine @entity4348 . METHODS: From 2004 to 2011, we identified 51 @entity1 treated at our institution fitting the above criteria. All @entity1 received surgical staging followed by adjuvant chemoradiation (external-beam radiation therapy (EBRT) with or without @entity1168 ( @entity1168 ) vaginal brachytherapy (VB)). Of these, 73% and 27% of @entity1 received their adjuvant therapy in sequential and sandwich fashion, respectively. RESULTS: There were no significant differences in clinical or pathologic factors between @entity1 treated with either regimen. Thirty-nine (76%) @entity1 had stage IIIC disease. The majority of @entity1 received 6cycles of @entity1311 with @entity3003 or @entity900 . Median EBRT dose was 45Gy and 54% of @entity1 received @entity1168 VB boost (median dose 21Gy). There were no significant differences in the estimated 5-year overall survival, local progression-free survival, and distant metastasis-free survival between the sequential and sandwich groups: 87% vs. 77% (p=0.37), 89% vs. 100% (p=0.21), and 78% vs. 85% (p=0.79), respectively. No grade 3-4 genitourinary or gastrointestinal @entity137 were reported in either group. There was a trend towards higher incidence of grade 3-4 hematologic @entity137 in the sandwich group. CONCLUSION: Adjuvant chemoradiation for FIGO stage III endometrioid uterine @entity5 given in either sequential or sandwich fashion appears to offer equally excellent early clinical outcomes and acceptably low @entity137 .

title: Sequential versus "sandwich" sequencing of adjuvant chemoradiation for the treatment of stage III uterine XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['high-dose rate', 'HDR']

entities_list: @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid adenocarcinoma']

answer: @entity4348 :: (MESH:D018269,Disease) :: ['endometrioid adenocarcinoma']


abstract: UNASSIGNED: A @entity717 ( @entity717 ) taskforce recently proposed diagnostic criteria for @entity191 with features of mild @entity73 ( @entity1726 ). This study first examined the prevalence and nature of @entity1726 in a non-demented cohort using the @entity717 criteria. Using the generic Monte Carlo simulation method developed by Crawford and colleagues (2007), this study then estimated the base rate of the representative population who would demonstrate @entity1726 due to chance alone. A total of 104 @entity1 with idiopathic @entity1726 underwent extensive motor and neuropsychological testing at baseline and 2 years later. The Unified @entity191 Rating Scale (UPDRS) was used to assess motor symptoms of @entity1726 and a range of established neuropsychological tests was used to assess @entity1726 in accord with @entity717 criteria. In accord with @entity717 criteria, 38% of this cohort demonstrated @entity1726 at baseline and 48% at follow-up. Of the 36 @entity1 in the multiple-domain @entity1726 subtype at time-1, 9 (25%) demonstrated no @entity1726 at follow up. Analysis revealed that approximately 13% of the representative population would demonstrate abnormally low scores for 2 of the 9 tests used, thereby meeting @entity717 criteria for @entity1726 . Clinicians and researchers need to approach a single diagnosis (i.e., based on one assessment) of @entity1726 with considerable caution. (JINS, 2015, 21, 1-9).

title: Retrospective Assessment of XXXX Criteria for Mild @entity73 in @entity191 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", "Parkinson's Disease"]

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['MDS', 'Movement Disorder Society']

answer: @entity717 :: (MESH:D009069,Disease) :: ['Movement Disorder Society']


abstract: UNASSIGNED: A @entity717 ( @entity717 ) taskforce recently proposed diagnostic criteria for @entity191 with features of mild @entity73 ( @entity1726 ). This study first examined the prevalence and nature of @entity1726 in a non-demented cohort using the @entity717 criteria. Using the generic Monte Carlo simulation method developed by Crawford and colleagues (2007), this study then estimated the base rate of the representative population who would demonstrate @entity1726 due to chance alone. A total of 104 @entity1 with idiopathic @entity1726 underwent extensive motor and neuropsychological testing at baseline and 2 years later. The Unified @entity191 Rating Scale (UPDRS) was used to assess motor symptoms of @entity1726 and a range of established neuropsychological tests was used to assess @entity1726 in accord with @entity717 criteria. In accord with @entity717 criteria, 38% of this cohort demonstrated @entity1726 at baseline and 48% at follow-up. Of the 36 @entity1 in the multiple-domain @entity1726 subtype at time-1, 9 (25%) demonstrated no @entity1726 at follow up. Analysis revealed that approximately 13% of the representative population would demonstrate abnormally low scores for 2 of the 9 tests used, thereby meeting @entity717 criteria for @entity1726 . Clinicians and researchers need to approach a single diagnosis (i.e., based on one assessment) of @entity1726 with considerable caution. (JINS, 2015, 21, 1-9).

title: Retrospective Assessment of @entity717 Criteria for Mild @entity73 in XXXX .

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's Disease']


abstract: UNASSIGNED: A @entity717 ( @entity717 ) taskforce recently proposed diagnostic criteria for @entity191 with features of mild @entity73 ( @entity1726 ). This study first examined the prevalence and nature of @entity1726 in a non-demented cohort using the @entity717 criteria. Using the generic Monte Carlo simulation method developed by Crawford and colleagues (2007), this study then estimated the base rate of the representative population who would demonstrate @entity1726 due to chance alone. A total of 104 @entity1 with idiopathic @entity1726 underwent extensive motor and neuropsychological testing at baseline and 2 years later. The Unified @entity191 Rating Scale (UPDRS) was used to assess motor symptoms of @entity1726 and a range of established neuropsychological tests was used to assess @entity1726 in accord with @entity717 criteria. In accord with @entity717 criteria, 38% of this cohort demonstrated @entity1726 at baseline and 48% at follow-up. Of the 36 @entity1 in the multiple-domain @entity1726 subtype at time-1, 9 (25%) demonstrated no @entity1726 at follow up. Analysis revealed that approximately 13% of the representative population would demonstrate abnormally low scores for 2 of the 9 tests used, thereby meeting @entity717 criteria for @entity1726 . Clinicians and researchers need to approach a single diagnosis (i.e., based on one assessment) of @entity1726 with considerable caution. (JINS, 2015, 21, 1-9).

title: Retrospective Assessment of @entity717 Criteria for Mild XXXX in @entity191 .

answer: @entity73 :: (MESH:D003072,Disease) :: ['Cognitive Impairment']


abstract: A survey of medical examinations has been made on occupational @entity751 (O.M.A.S.). We have examined and treated on 358 @entity1 with O.M.A.S. during the past 10-15 years at two clinics; one was a company's clinic (this company has 15,000 employees) and the other was the clinic at the Dept. of Mental Health, Osaka Prefectural Institute of Public Health during the past 15 years. Discussions have been made on 150 @entity1 whom we directly treated. Our 358 subjects having O.M.A.S. do not include those with secondary O.M.A. resulting from @entity716 , @entity308 , @entity11167 and @entity73 . From that reason, our subjects are categorized in a narrow sense, in a category which may be called as " @entity2166 ." The results are summarized as follows. 1. The @entity1 with O.M.A.S. were found almost in males and most commonly found among @entity1 in the twenties. 2. The average rate of @entity1 with O.M.A.S. among all the @entity1 who visited two clinics, was 4.1% at our clinic and 16.7% at the company's clinic. 3. At our clinic, the number of @entity1 with O.M.A.S. was followed by the number of those with @entity11167 , @entity161 and @entity162 . This trend was also the same at the company's clinic. 4. As the cause of O.M.A.S., we found the following occupational factors; firstly, transposition by selective promotion, secondly, complication of job-quality, and thirdly, promotion to middle management position. As to personal factors, i.e. as to characteristic individual personality we found mostly rigid and serious trait, next @entity44 and egotism, and timidity and nervousness. 5. The relation between the occupational and individual factors was examined from the psychodynamic point of view. From the result, O.M.A.S. was classified into 5 groups which consisted of the core group, dropout group, special job maladjustment group, transient reaction group and others. 6. In conclusion of the above mentioned data, the authors emphasize that it is important to explain and advise by the therapists not only for @entity1 and their families, but also for their colleagues or superiors in their working place.

title: [Studies on the occupational XXXX . With reference to the survey of examinations, etiological factors and treatment].

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['manic-depressive psychotic zone']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['physical impairment']

entities_list: @entity2166 :: ('MESH:D000275', 'Disease') :: ['adjustment disorder']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['maladjustment syndrome']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['immaturity']

answer: @entity751 :: (MESH:D013577,Disease) :: ['maladjustment syndrome']


abstract: BACKGROUND: The burden of @entity6 ( @entity6 ) is on the rise especially in developing countries like India. Due to its chronic @entity6 tends to cause many debilitating complications and @entity1897 ( @entity1897 ) is one of them. The aim of this study is to determine the prevalence of @entity1897 among @entity1 attending a tertiary care hospital and to identify the determinants associated with it. DESIGN AND METHODS: A cross sectional study was conducted in Government Wenlock Hospital, Mangalore (India), during January-February 2014. A total of 208 @entity1 with >5 year duration of @entity6 were asked to respond to the @entity1 history version of @entity16 Screening Instrument (MNSI) and examinations were conducted after obtaining consent from them. The statistical analysis was done in terms of descriptive statistics and association between variables was tested using logistic regression test. RESULTS: The prevalence of @entity1897 using the MNSI history version and MNSI examination were found to be 18.3% and 32.2% respectively. The major determinants associated with @entity1897 were found to be male gender (OR: 2.7, CI: 1.4-5.1, P=0.001), smoking (OR: 5.8, CI: 1.9-17.3, P=0.001) and age >40 years (OR: 2.7, CI: 1.2-5.8, P=0.011). CONCLUSIONS: The burden of undetected @entity1897 was found to be higher among @entity6 , with an especially higher prevalence among males, smokers and those with @entity6 . Interventions in the form of early detection through routine screening, smoking cessation and regular follow up examinations would go a long way in reducing the @entity717 among @entity6 and improve their quality of life significantly. Significance for public healthThe findings of the current research hold importance since @entity6 is one of the leading causes of morbidity and mortality across the world. Due to its chronic nature and effects of hyperglycaemia, @entity6 tends to be associated with many comorbidities, like @entity1897 , @entity8 , @entity989 etc. The presence of @entity1897 leads to a reduced quality of life among @entity6 @entity1 due to the @entity130 and consequent gangrenes andamputation. The concept of secondary prevention can be applied to the prevention of @entity1897 using easy to apply screening tools and thus help in early diagnosis and treatment to reduce the burden of this debilitating illness.

title: XXXX and its Determinants among @entity1 Attending a Tertiary Health Care Centre in Mangalore, India.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic', 'long standing diabetes mellitus', 'diabetes', 'diabetes mellitus', 'DM', 'nature DM']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Michigan Neuropathy']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['DPN', 'peripheral neuropathy', 'diabetic peripheral neuropathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['burden of disability']

answer: @entity1897 :: (MESH:D010523,Disease) :: ['Diabetic Peripheral Neuropathy']


abstract: BACKGROUND: The burden of @entity6 ( @entity6 ) is on the rise especially in developing countries like India. Due to its chronic @entity6 tends to cause many debilitating complications and @entity1897 ( @entity1897 ) is one of them. The aim of this study is to determine the prevalence of @entity1897 among @entity1 attending a tertiary care hospital and to identify the determinants associated with it. DESIGN AND METHODS: A cross sectional study was conducted in Government Wenlock Hospital, Mangalore (India), during January-February 2014. A total of 208 @entity1 with >5 year duration of @entity6 were asked to respond to the @entity1 history version of @entity16 Screening Instrument (MNSI) and examinations were conducted after obtaining consent from them. The statistical analysis was done in terms of descriptive statistics and association between variables was tested using logistic regression test. RESULTS: The prevalence of @entity1897 using the MNSI history version and MNSI examination were found to be 18.3% and 32.2% respectively. The major determinants associated with @entity1897 were found to be male gender (OR: 2.7, CI: 1.4-5.1, P=0.001), smoking (OR: 5.8, CI: 1.9-17.3, P=0.001) and age >40 years (OR: 2.7, CI: 1.2-5.8, P=0.011). CONCLUSIONS: The burden of undetected @entity1897 was found to be higher among @entity6 , with an especially higher prevalence among males, smokers and those with @entity6 . Interventions in the form of early detection through routine screening, smoking cessation and regular follow up examinations would go a long way in reducing the @entity717 among @entity6 and improve their quality of life significantly. Significance for public healthThe findings of the current research hold importance since @entity6 is one of the leading causes of morbidity and mortality across the world. Due to its chronic nature and effects of hyperglycaemia, @entity6 tends to be associated with many comorbidities, like @entity1897 , @entity8 , @entity989 etc. The presence of @entity1897 leads to a reduced quality of life among @entity6 @entity1 due to the @entity130 and consequent gangrenes andamputation. The concept of secondary prevention can be applied to the prevention of @entity1897 using easy to apply screening tools and thus help in early diagnosis and treatment to reduce the burden of this debilitating illness.

title: @entity1897 and its Determinants among XXXX Attending a Tertiary Health Care Centre in Mangalore, India.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVE: The aims of this article are to review the imaging characteristics of ischiofemoral impingement (IFI), summarize measurement thresholds for radiologic diagnosis based on a meta-analysis of the literature and raise awareness among radiologists and clinicians of this entity. MATERIALS AND METHODS: A PubMed search restricted to the English language containing the keywords "ischiofemoral impingement" and "quadratus femoris MRI" was performed, and citations in these articles were also used to identify a total of 27 studies discussing ischiofemoral impingement. After excluding case reports and non-representative studies, there were five remaining articles including 193 hip MRIs of IFI in 154 subjects (133 female, 21 male) and 135 asymptomatic control hip MRIs from 74 subjects (55 female, 19 male). Additionally, we performed a retrospective database search of pelvic and hip MRI reports from our institution including the terms "quadratus femoris" or "ischiofemoral impingement" from a 9-year period and 24 hip MRIs from 21 @entity1 (18 female, 3 male) with IFI with 5 asymptomatic contralateral control hip MRIs identified. In all, 217 hip MRIs of IFI and 140 control cases were included. A meta-analysis of these hip MRIs was conducted to determine optimal thresholds of the ischiofemoral space (IFS) and @entity3626 ( @entity3626 ) for identifying IFI. RESULTS: Cases of IFI showed significantly smaller IFS and @entity3626 compared to controls (14.91    4.8 versus 26.01    7.98 and 9.57    3.7 versus 15.97    6.07, measured in mm, respectively, p   <   0.0001 for both). Pooled analysis revealed that for IFS, using a cutoff of    <=15  mm yielded a sensitivity of 76.9  %, specificity of 81.0  % and overall accuracy of 78.3  %. For @entity3626 , a cutoff of    <=   10.0  mm resulted in 78.7  % sensitivity, 74.1  % specificity and 77.1  % overall accuracy. CONCLUSION: IFI is a potential cause of @entity158 that can be accurately diagnosed with MRI in conjunction with clinical findings. Using the proposed measurement thresholds may better identify @entity1 with this @entity5818 so that optimal treatment options can be pursued.

title: XXXX : a meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3626 :: ('MESH:D018489', 'Disease') :: ['QFS', 'quadratus femoris space']

entities_list: @entity5818 :: ('MESH:D019534', 'Disease') :: ['impingement syndrome']

answer: @entity5818 :: (MESH:D019534,Disease) :: ['Ischiofemoral impingement syndrome']


abstract: During complete medical checkup of proximal gastrointestinal tract, the esophagus pH measurement is an adventive procedure that requires probes usage, which is introduced through the endoscope biopsy channel. Such procedure cannot be used for everyday dynamic treatment control because of its invasiveness. The main aim of this article is to develop an effective everyday quality control of @entity66 non-traumatic antisecretory treatment. We solve the problem by measuring the air-ionic esophagus internal environment characteristics with the help of the air exhaled by the @entity1 analysis. Initial examination is provided during endoscopic research in the period of @entity1 's planned checkup. Esophagus air tests are get through biopsy channel and analyzed by computer air-ionic complex. The range of air-ionic concentration in the esophagus air content is 0.060-0.040 (60-40%) in electrical voltage 0.020-0.050 V, which corresponds to pH 5.0-7.0. The esophagus air content indexes, received from primary samples are used as gauging for air-ionic characteristics of air exhausted by @entity1 . Hereafter, during the therapy course we study only air samples exhausted by the @entity1 on a daily basis. Air-ionic esophageal pH - measurement is used during checkup and treatment of 42 @entity1 with @entity354 diagnose. Parallel usage of invasive esophageal pH determination method demonstrated complete results match. Thus, the proposed method is an advanced non-invasive diagnostic method, which allows to measure intra-esophagus pH indexes and provides probable assessment of antisecretory drugs treatment efficacy with an ability of therapeutic course operative correction.

title: Dynamic control of pH in XXXX treatment.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['esophagus diseases']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease']

answer: @entity66 :: (MESH:D004194,Disease) :: ['esophagus diseases']


abstract: BACKGROUND: Using a simple standing-up test in normotensive subjects, we evaluated orthostatic upright postural blood pressure (BP) changes and autonomic nervous function, as well as the relationship between orthostatic BP changes and subclinical markers of @entity731 . METHODS: A total of 515 normotensive subjects aged 35-75 years (58.4  10.0 years) were enrolled. We measured body mass index (BMI), @entity13519 (DBP), serum lipids, hemoglobin A1c (HbA1c), high-sensitivity C-reactive protein (hs-CRP), and urinary albumin-to- @entity1011 ratio. Brachial to ankle pulse wave velocity (baPWV) and carotid mean @entity121 ( @entity121 ) were measured. @entity1 underwent a simple standing-up test involving sitting then standing for 2 minutes each, followed again by sitting. To evaluate autonomic fluctuations, we calculated the coefficient of variation of the R-R interval, the ratio of low to high frequency heart rate variability (LF/HF), and the coefficient of component variance of high frequency. RESULTS: @entity13519 and DBP decreased when standing, with a reduction of @entity13519 when changing position of -8.0  10.2mm Hg. @entity551 ( @entity551 ) produced a significantly higher @entity13519 than without @entity551 . The baPWV was significantly higher in @entity551 than in without @entity551 . Stepwise regression analysis adjusted for age, sex, BMI, baseline @entity13519 , @entity1674 , high-density lipoprotein @entity165 , low-density lipoprotein @entity165 , fasting @entity413 , HbA1c, hs-CRP, @entity121 , late systolic peak of the pressure wave form ( @entity24022 ), and baPWV confirmed that baPWV, @entity24022 , and @entity1674 were independently related to orthostatic BP changes. Multiple regression analyses showed that a decrease in @entity13519 as well as baseline @entity13519 , age, BMI, and fasting @entity413 were independent determinants of @entity122 . CONCLUSIONS: We have shown that increased arterial stiffness was associated with @entity551 during a standing-up test. Arterial stiffness may contribute to greater BP responses to postural changes from standing.

title: Orthostatic Blood Pressure Changes and Subclinical Markers of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity13519 :: ('8991', 'Gene') :: ['systolic BP (SBP) and diastolic BP', 'SBP']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['Orthostatic hypotension', 'OH']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']


abstract: UNASSIGNED: Background and purpose - There is no consensus on which type of shoulder prosthesis should be used in @entity1 with @entity309 ( @entity309 ). We describe @entity1 with @entity309 who were treated with shoulder replacement, regarding @entity1 -reported outcome, prosthesis survival, and causes of revision, and we compare outcome after @entity11126 ( @entity11126 ) and @entity11126 ( @entity11126 ). @entity1 and methods - We used data from the national Danish Shoulder Arthroplasty Registry and included @entity1 with @entity309 who underwent shoulder arthroplasty in Denmark between 2006 and 2010. @entity1 -reported outcome was obtained 1-year postoperatively using the Western Ontario @entity571 of the Shoulder index (WOOS), and rates of revision were calculated by checking revisions reported until December 2011. The @entity1 -reported outcome of @entity11126 was compared to that of @entity11126 using regression analysis with adjustment for age, sex, and previous surgery. Results - During the study period, 167 @entity1 underwent shoulder arthroplasty because of @entity309 , 80 (48%) of whom received @entity11126 and 34 (26%) of whom received @entity11126 . 16 @entity1 were treated with @entity348 ( @entity348 ), and 24 were treated with reverse shoulder arthroplasty (rTSA). 130 @entity1 returned a completed questionnaire, and the total mean WOOS score was 63. The cumulative 5-year revision rate was 7%. Most revisions occurred after @entity11126 , with a revision rate of 14%. Mean WOOS score was similar for @entity11126 and for @entity11126 . Interpretation - This study shows that shoulder arthroplasty, regardless of design, is a good option in terms of reducing @entity158 and improving function in @entity309 @entity1 . The high revision rate in the @entity11126 group suggests that other designs may offer better implant survival. However, this should be confirmed in larger studies.

title: Resurfacing shoulder arthroplasty for the treatment of severe XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient']

entities_list: @entity11126 :: ('MESH:C565524', 'Disease') :: ['RHA', 'resurfacing hemi-arthroplasty', 'stemmed hemi-arthroplasty', 'SHA']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['TSA', 'total stemmed shoulder arthroplasty']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: This study was aimed to investigate the effect of stress induced by high-intensity exercises on the cardiovascular system. In the epidemiological investigation, 200 subjects (test group) engaged in special high-intensity exercises, and 97 who lived and worked in the same environment and conditions as those in the test group, but did not participate in the exercises served as controls. In the second part of the study, 50 @entity19 were randomly divided into control group, exhaustive swimming group, white noise group, exhaustive swimming plus white noise group, and pioglitazone intervention group. The results showed that the plasma concentrations of the @entity296 markers heart fatty acid-binding protein (H-FABP), @entity24759 ( @entity24759 ), b-endorphin (b-EP) and levels of psychological stress were significantly increased in test group as compared with control group; special high-intensity exercises resulted in a significant elevation of the incidence of @entity943 . Animal experiments showed that the plasma levels of corticosterone (CORT) and troponin I (TnI) were raised while the level of SOD was reduced in exhaustive swimming group, white noise group, and exhaustive swimming plus white noise group. The expression levels of PPARy mRNA and protein were decreased in myocardial tissues in these groups as well. HE staining showed no remarkable change in myocardial tissues in all the groups. Treatment with pioglitazone significantly decreased the plasma levels of TnI and CORT, while increased the level of SOD and the expression levels of PPARy mRNA and protein. It was concluded that the high-intensity exercises may induce a heavy physical and psychological stress and predispose the subjects to accumulated @entity1949 ; high-intensity exercises also increases the incidence of @entity943 and @entity296 . PPARy may be involved in the physical and psychological changes induced by high-intensity exercises.

title: Association between cardiac changes and stress, and the effect of peroxisome proliferator-activated receptor-y on stress-induced XXXX in @entity19 .

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury']

entities_list: @entity1949 :: ('MESH:D012892', 'Disease') :: ['fatigue and sleep deprivation']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmias', 'arrhythmias']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial injury']