abstract: The haemodynamic effects of a simultaneous infusion of @entity3045 and @entity1854 were measured in 20 @entity1 with @entity583 and severe @entity1002 . Six @entity1 also had clinical manifestations of @entity1455 . Ten @entity1 received @entity3045 first with the subsequent addition of @entity1854 ; in the other 10 @entity1 @entity1854 was infused first. @entity3045 was infused at a constant rate of 20 micrograms/min in all @entity1 , while the dose of @entity1854 , which averaged 51.25 micrograms/min, was adjusted to reduce left ventricular filling pressure (measured as pulmonary artery end-diastolic pressure) to approximately 15 mm Hg with reference to sternal angle. Cardiac index increased in all @entity1 from a mean of 1.8 to 2.6 l/min/m2 while pulmonary artery end-diastolic pressure fell significantly from 24 to 16 mm Hg. The adverse effects were small in most @entity1 : heart rate did not increase significantly and systolic arterial pressure fell on average from 112 to 96 mm Hg. Ten of the 20 @entity1 survived to leave hospital. @entity1854 accounted for most of the fall in filling pressure irrespective of treatment sequence, whereas both drugs contributed to the @entity998 . The haemodynamic benefits of this combined regimen were considerably greater than those achieved by either drug alone. Thus @entity3045 and @entity1854 have synergistic effects which influence favourably the two principal manifestations of @entity1002 after extensive @entity583 .

title: Synergistic effects of a combined @entity3045 - XXXX regimen in @entity583 and severe @entity1002 .

entities_list: @entity998 :: ('MESH:D002303', 'Disease') :: ['augmented cardiac output']

entities_list: @entity3045 :: ('MESH:D000420', 'Chemical') :: ['salbutamol', 'Salbutamol']

entities_list: @entity1854 :: ('MESH:D009599', 'Chemical') :: ['Nitroprusside', 'nitroprusside']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'acute myocardial infarction']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular failure', 'left ventricular dysfunction']

answer: @entity1854 :: (MESH:D009599,Chemical) :: ['nitroprusside']


abstract: The haemodynamic effects of a simultaneous infusion of @entity3045 and @entity1854 were measured in 20 @entity1 with @entity583 and severe @entity1002 . Six @entity1 also had clinical manifestations of @entity1455 . Ten @entity1 received @entity3045 first with the subsequent addition of @entity1854 ; in the other 10 @entity1 @entity1854 was infused first. @entity3045 was infused at a constant rate of 20 micrograms/min in all @entity1 , while the dose of @entity1854 , which averaged 51.25 micrograms/min, was adjusted to reduce left ventricular filling pressure (measured as pulmonary artery end-diastolic pressure) to approximately 15 mm Hg with reference to sternal angle. Cardiac index increased in all @entity1 from a mean of 1.8 to 2.6 l/min/m2 while pulmonary artery end-diastolic pressure fell significantly from 24 to 16 mm Hg. The adverse effects were small in most @entity1 : heart rate did not increase significantly and systolic arterial pressure fell on average from 112 to 96 mm Hg. Ten of the 20 @entity1 survived to leave hospital. @entity1854 accounted for most of the fall in filling pressure irrespective of treatment sequence, whereas both drugs contributed to the @entity998 . The haemodynamic benefits of this combined regimen were considerably greater than those achieved by either drug alone. Thus @entity3045 and @entity1854 have synergistic effects which influence favourably the two principal manifestations of @entity1002 after extensive @entity583 .

title: Synergistic effects of a combined XXXX - @entity1854 regimen in @entity583 and severe @entity1002 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity3045 :: (MESH:D000420,Chemical) :: ['salbutamol']


abstract: The haemodynamic effects of a simultaneous infusion of @entity3045 and @entity1854 were measured in 20 @entity1 with @entity583 and severe @entity1002 . Six @entity1 also had clinical manifestations of @entity1455 . Ten @entity1 received @entity3045 first with the subsequent addition of @entity1854 ; in the other 10 @entity1 @entity1854 was infused first. @entity3045 was infused at a constant rate of 20 micrograms/min in all @entity1 , while the dose of @entity1854 , which averaged 51.25 micrograms/min, was adjusted to reduce left ventricular filling pressure (measured as pulmonary artery end-diastolic pressure) to approximately 15 mm Hg with reference to sternal angle. Cardiac index increased in all @entity1 from a mean of 1.8 to 2.6 l/min/m2 while pulmonary artery end-diastolic pressure fell significantly from 24 to 16 mm Hg. The adverse effects were small in most @entity1 : heart rate did not increase significantly and systolic arterial pressure fell on average from 112 to 96 mm Hg. Ten of the 20 @entity1 survived to leave hospital. @entity1854 accounted for most of the fall in filling pressure irrespective of treatment sequence, whereas both drugs contributed to the @entity998 . The haemodynamic benefits of this combined regimen were considerably greater than those achieved by either drug alone. Thus @entity3045 and @entity1854 have synergistic effects which influence favourably the two principal manifestations of @entity1002 after extensive @entity583 .

title: Synergistic effects of a combined @entity3045 - @entity1854 regimen in @entity583 and severe XXXX .

answer: @entity1002 :: (MESH:D018487,Disease) :: ['left ventricular failure']


abstract: The haemodynamic effects of a simultaneous infusion of @entity3045 and @entity1854 were measured in 20 @entity1 with @entity583 and severe @entity1002 . Six @entity1 also had clinical manifestations of @entity1455 . Ten @entity1 received @entity3045 first with the subsequent addition of @entity1854 ; in the other 10 @entity1 @entity1854 was infused first. @entity3045 was infused at a constant rate of 20 micrograms/min in all @entity1 , while the dose of @entity1854 , which averaged 51.25 micrograms/min, was adjusted to reduce left ventricular filling pressure (measured as pulmonary artery end-diastolic pressure) to approximately 15 mm Hg with reference to sternal angle. Cardiac index increased in all @entity1 from a mean of 1.8 to 2.6 l/min/m2 while pulmonary artery end-diastolic pressure fell significantly from 24 to 16 mm Hg. The adverse effects were small in most @entity1 : heart rate did not increase significantly and systolic arterial pressure fell on average from 112 to 96 mm Hg. Ten of the 20 @entity1 survived to leave hospital. @entity1854 accounted for most of the fall in filling pressure irrespective of treatment sequence, whereas both drugs contributed to the @entity998 . The haemodynamic benefits of this combined regimen were considerably greater than those achieved by either drug alone. Thus @entity3045 and @entity1854 have synergistic effects which influence favourably the two principal manifestations of @entity1002 after extensive @entity583 .

title: Synergistic effects of a combined @entity3045 - @entity1854 regimen in XXXX and severe @entity1002 .

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']


abstract: The role of proprioceptive input from the ankle extensor triceps surae in the control of walking was examined in premammillary @entity468 walking on a treadmill. The left hindlimb was rigidly fixed in one position after denervating almost all the leg muscles except the ankle extensor (triceps surae) and ankle flexor (tibialis anterior). Rhythmic alternating @entity2472 of the isolated ankle flexor and extensor occurred in the fixed hindleg during periods of walking in the other three intact limbs. These rhythmic @entity2472 disappeared when the isolated triceps surae was stretched so as to increase the force of the active @entity2472 to beyond 4 kg. With maintained stretch the periodic @entity2472 in the ankle flexor and extensor returned only after the force in the stretched triceps surae gradually decreased and fell below approximately 4 kg. Isometric @entity2472 of the triceps surae produced either by stimulation of ventral root S1 or by large amplitude vibrations also led to the @entity3681 . Inhibition of the locomotory rhythm could also be produced in all muscles of a single intact hindleg by clamping the ankle joint in a flexed position so as to stretch the ankle extensor. In all these cases, an increased rate of stepping of the contralateral hindleg was associated with the inhibition of the rhythmic locomotory activity. It is suggested that triceps surae proprioceptors signalling the presence of loading of the hindlimb extensor muscles inhibit the central generation of hindlimb flexion. During normal walking this mechanism could be of major importance during stance to prevent the initiation of the swing phase of a time when hindlimb extension is fully needed to support the weight of the animal. Thus a necessary, but not always sufficient, condition for the initiation of swing may be an unloading of leg extensor muscles.

title: Inhibition of flexor burst generation by loading ankle extensor muscles in walking XXXX .

entities_list: @entity3681 :: ('MESH:D016512', 'Disease') :: ['sudden disappearance of ankle flexor bursts']

entities_list: @entity2472 :: ('MESH:C536214', 'Disease') :: ['contractions']

answer: @entity468 :: (9685,Species) :: ['cats']


abstract: BACKGROUND: Traumatic @entity8495 (TDIs) are significant clinical problems that may have complex etiologies and may cause physical and physiological impairment. AIM: The aim of this study was to determine the demographic and clinical characteristics of TDIs in a group of Turkish subjects. MATERIALS AND METHODS: The prevalence of TDIs and the pattern of traumatized teeth were studied in relation to age, gender, cause, location, and @entity130 . This study was carried out to include all age groups and teeth. TDIs were recorded using the World Health Organization classification modified by Andreasen et al. RESULTS: The prevalence of TDIs was found to be 4.4% (255 injured @entity1 /5800 presented @entity1 ), and the injuries were most commonly observed in the age group of 11-20 years. Males were more affected than females (males, 153; females, 102). The most common cause of @entity130 was falling (68.2%), and the most common place of @entity130 was outdoors (56.1%). 4, 7% of @entity1 injured because of their @entity262 diseases. The most frequently injured teeth were the upper central incisors (primary teeth, 64.5%; permanent teeth, 72.5%), and the most common type of @entity8495 was uncomplicated crown @entity174 in both primary (63%) and permanent dentition (47%). CONCLUSION: In the surveyed population, the prevalence of TDIs was found to be low. However, the teacher and family of adolescents and the caregivers of @entity1 with some @entity262 diseases like @entity302 should be warned about TDIs.

title: Evaluation of traumatic XXXX in a group of Turkish population.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic']

entities_list: @entity8495 :: ('MESH:D018677', 'Disease') :: ['dental injuries', 'dental injury']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury', 'type of injury', 'trauma']

answer: @entity8495 :: (MESH:D018677,Disease) :: ['dental injuries']


abstract: OBJECTIVES: Simultaneous lateral augmentation and implant placement is considered as standard procedure in @entity5386 in oral implantology. Histological studies monitoring osteogenesis after application of alloplastic bone substitutes in @entity1 are scarce. Bone formation upon simultaneous augmentation with @entity71723 (BCP) and implantation was histologically investigated after 6  months in situ. The results of this secondary analysis are reported tempting to ascribe specific observations to uneventful submerged healing or compromised healing of soft tissues including occurrence of dehiscences and premature graft exposure. MATERIALS AND METHODS: Histology of biopsies from lateral, crestal bone augmentations using alloplastic BCP comprising seven sites with compromised, prematurely exposed healing and six sites with uneventful submerged healing was investigated for expression of osteogenic, osteoclastogenic, and angiogenic differentiation markers. RESULTS: Histology revealed @entity623 ( @entity623 )-positive osteoblasts and immunoreactivity for osteogenic markers osteocalcin and collagen type I in biopsies with submerged healing, while inflammatory infiltrates and accumulations of multinucleated giant cells around BCP granules were observed in compromised sites. All specimens presented adequate vessel density. Multinucleated giant cells showed inconsistent staining for the osteoclast marker @entity5272 -resistant acid phosphatase (TRAP). CONCLUSIONS: The histological findings of this study indicate an osteoconductive nature of the BCP applied. Premature exposure of the bone substitute reduced new bone formation and may bear a risk for inflammatory and foreign body reactions. CLINICAL RELEVANCE: A predictable appositional bone formation in simultaneously augmented sites using BCP is linked to an uneventful healing process.

title: Tissue reactions after simultaneous alveolar ridge augmentation with biphasic calcium phosphate and implant insertion-histological and immunohistochemical evaluation in XXXX .

entities_list: @entity5272 :: ('MESH:C029768', 'Chemical') :: ['tartrate']

entities_list: @entity5386 :: ('MESH:D007575', 'Disease') :: ['deficient edentulous ridges']

entities_list: @entity71723 :: ('MESH:C074950', 'Chemical') :: ['biphasic calcium phosphate']

entities_list: @entity623 :: ('250', 'Gene') :: ['ALP', 'alkaline phosphatase']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: BACKGROUND: Only a few recent reports have suggested a correlation between @entity28 and @entity1744 ( @entity1744 ). We aimed to determine the prevalence and severity of @entity1744 in a prospective cohort of @entity28 @entity1 undergoing bariatric surgery in Nice Hospital (France). METHODS: One @entity28 @entity1 were included prospectively before bariatric surgery. A diagnosis of @entity1744 and each subtype was performed according to Rome-III criteria using a Bristol scale for stool consistency. @entity1 provided information on @entity1744 -related comorbidities, including chronic fatigue, @entity2704 , @entity615 , @entity354 ( @entity354 ), genitourinary problems, and @entity2210 . @entity1 completed questionnaires to assess the severity of @entity1744 , @entity354 , psychological factors ( @entity148 , @entity308 ), fatigue, and quality of life. RESULTS: Thirty @entity1 fulfilled the Rome-III criteria for @entity1744 . There was no difference in age, gender, or BMI between @entity28 @entity1 with or without @entity1744 . @entity28 @entity1 with @entity1744 reported a significantly higher prevalence of @entity354 , @entity2704 , @entity615 , genitourinary problems, chronic fatigue, and @entity2210 . @entity28 @entity1 with @entity1744 had significant higher scores of fatigue, @entity148 , @entity308 , and poorer quality of life. @entity28 @entity1 that had both @entity1744 and @entity354 had significantly higher @entity1744 severity scores than those without @entity354 . In a logistic regression model including BMI, @entity148 , @entity308 , gender, and @entity354 score, only @entity148 was significantly and independently associated with @entity1744 . CONCLUSIONS: Thirty percent of @entity28 @entity1 had @entity1744 : its severity was not correlated with BMI. However, @entity148 was independently associated with @entity1744 , suggesting that psychological factors are key features of @entity1744 , whatever the presence of @entity28 .

title: Increased Prevalence of Irritable Bowel Syndrome in a Cohort of French Morbidly XXXX @entity1 Candidate for Bariatric Surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['hundred obese', 'Obese', 'obese', 'obesity']

entities_list: @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine', 'migraines']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['lower back pain']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease', 'GERD']

entities_list: @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome', 'IBS']

answer: @entity28 :: (MESH:D009765,Disease) :: ['Obese']


abstract: BACKGROUND: Only a few recent reports have suggested a correlation between @entity28 and @entity1744 ( @entity1744 ). We aimed to determine the prevalence and severity of @entity1744 in a prospective cohort of @entity28 @entity1 undergoing bariatric surgery in Nice Hospital (France). METHODS: One @entity28 @entity1 were included prospectively before bariatric surgery. A diagnosis of @entity1744 and each subtype was performed according to Rome-III criteria using a Bristol scale for stool consistency. @entity1 provided information on @entity1744 -related comorbidities, including chronic fatigue, @entity2704 , @entity615 , @entity354 ( @entity354 ), genitourinary problems, and @entity2210 . @entity1 completed questionnaires to assess the severity of @entity1744 , @entity354 , psychological factors ( @entity148 , @entity308 ), fatigue, and quality of life. RESULTS: Thirty @entity1 fulfilled the Rome-III criteria for @entity1744 . There was no difference in age, gender, or BMI between @entity28 @entity1 with or without @entity1744 . @entity28 @entity1 with @entity1744 reported a significantly higher prevalence of @entity354 , @entity2704 , @entity615 , genitourinary problems, chronic fatigue, and @entity2210 . @entity28 @entity1 with @entity1744 had significant higher scores of fatigue, @entity148 , @entity308 , and poorer quality of life. @entity28 @entity1 that had both @entity1744 and @entity354 had significantly higher @entity1744 severity scores than those without @entity354 . In a logistic regression model including BMI, @entity148 , @entity308 , gender, and @entity354 score, only @entity148 was significantly and independently associated with @entity1744 . CONCLUSIONS: Thirty percent of @entity28 @entity1 had @entity1744 : its severity was not correlated with BMI. However, @entity148 was independently associated with @entity1744 , suggesting that psychological factors are key features of @entity1744 , whatever the presence of @entity28 .

title: Increased Prevalence of Irritable Bowel Syndrome in a Cohort of French Morbidly @entity28 XXXX Candidate for Bariatric Surgery.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: INTRODUCTION: @entity854 in @entity1 with opium addiction have not been widely evaluated by endoscopic ultrasonography before. MATERIALS AND METHODS: @entity1 without any @entity66 during 10 months were enrolled in this study. Common bile duct (CBD), @entity788 ( @entity788 ) and portal vein (PV) diameters, gallbladder wall thickness and surface area of the @entity854 were evaluated in both groups by endosonography. RESULTS: In total, 199 @entity1 were evaluated. 36 (18.1%) cases were addicted to opium. Mean age of the @entity1 was 56.0    14.2 years. Opium users had a statistically significant higher (all P < 0.001) mean diameters of distal CBD (4.6    1.9 vs. 3.1    1.0 mm), middle part of CBD (7.5    3.1 vs. 4.6    1.6 mm), @entity788 in head (3.3    1.3 vs. 2.3    0.7 mm) and PV (10.3    2.3 vs. 8.9    2.1 mm). However, the difference in the diameters of @entity788 in the body of pancreas and gallbladder wall thickness did not reach statistical significance. The size of the papilla as measured by the surface area of the papilla of Vater was also significantly larger in opium users (40.6    17.1 vs. 29.9    13.5, P < 0.001). CONCLUSION: Opium addicted @entity1 have larger diameters of CBD, PV and a larger surface area of the papilla of Vater. Dilated @entity788 only in the head of the pancreas might be an important clue to differentiate @entity15149 -induced CBD dilation from @entity5 and chronic @entity788 . The clinical significance of these findings warrants further investigation.

title: Evaluation of opium effect on pancreatobiliary system in opium addicted XXXX by endoscopic ultrasonography.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'persons']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'pancreatic duct', 'PD']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['pancreatobiliary disease or symptom']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['periampullary tumors']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['Pancreatobiliary abnormalities', 'papilla and abnormalities']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: The study objectives were to estimate @entity10108 prevalence among @entity1 living next to an industrial area, to compare it to that in a control population, and to establish clinical and biological follow-up of the poisoned @entity1 . This is a descriptive cross-sectional study including 150 @entity1 (exposed and unexposed) performed between January 2012 and April 2013. It was meant to determine blood lead levels (BLLs) in @entity1 considered to be an exposed population (EP N 90), living in the industrial area Ain Nokb @entity15164 compared with BLLs of @entity1 of other areas belonging to the same city supposed to be unexposed [UP (N  =  60)]. A sociodemographic questionnaire was obtained, and a blood lead analysis was performed. Clinical and biological follow-up has been performed of poisoned @entity1 . The sample consisted of 90 EP @entity1 with an average age of 6.82      3.32  years and male-to-female sex ratio (SR) of 1.5 and 60 UP @entity1 with an average age of 6.45      3.29  years and an SR of 1.2. Among the 150 @entity1 recruited, the average of BLLs was 58.21      36    g/L (18-202.3   g/L). The average of BLLs in EP @entity1 (71      40    g/L) was statistically greater (p  <  0.0001) than that registered in UP @entity1 (38      13    g/L). All poisoned @entity1 belonged to the EP group at a prevalence of 21.1  %. The clinical and biological examinations of poisoned @entity1 showed a few perturbations such as @entity417 , hypocalcaemia, and deficiencies in @entity1760 and @entity68 . No @entity8 or objective @entity16 were observed. In the follow-up of the @entity1 with BLL >= 100    g/L (19 cases). BLL monitoring showed a significant decrease in average of blood concentration ranging from 136.75      32.59 to 104.58      32.73    g/L (p  <  0.0001) and in @entity10108 prevalence (p  <  0.001), which decreased to 7.8  % from 21.1. Our study showed a high prevalence of @entity10108 (21.1  %) in EP @entity1 . The relocation of the industrial site associated with corrective and preventive measures has contributed to a decrease of exposure and @entity10108 prevalence in the aforementioned population.

title: Screening for Childhood XXXX in the Industrial Region of @entity15164 , Morocco.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease']

entities_list: @entity10108 :: ('MESH:D007855', 'Disease') :: ['lead poisoning']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity10108 :: (MESH:D007855,Disease) :: ['Lead Poisoning']


abstract: UNASSIGNED: The study objectives were to estimate @entity10108 prevalence among @entity1 living next to an industrial area, to compare it to that in a control population, and to establish clinical and biological follow-up of the poisoned @entity1 . This is a descriptive cross-sectional study including 150 @entity1 (exposed and unexposed) performed between January 2012 and April 2013. It was meant to determine blood lead levels (BLLs) in @entity1 considered to be an exposed population (EP N 90), living in the industrial area Ain Nokb @entity15164 compared with BLLs of @entity1 of other areas belonging to the same city supposed to be unexposed [UP (N  =  60)]. A sociodemographic questionnaire was obtained, and a blood lead analysis was performed. Clinical and biological follow-up has been performed of poisoned @entity1 . The sample consisted of 90 EP @entity1 with an average age of 6.82      3.32  years and male-to-female sex ratio (SR) of 1.5 and 60 UP @entity1 with an average age of 6.45      3.29  years and an SR of 1.2. Among the 150 @entity1 recruited, the average of BLLs was 58.21      36    g/L (18-202.3   g/L). The average of BLLs in EP @entity1 (71      40    g/L) was statistically greater (p  <  0.0001) than that registered in UP @entity1 (38      13    g/L). All poisoned @entity1 belonged to the EP group at a prevalence of 21.1  %. The clinical and biological examinations of poisoned @entity1 showed a few perturbations such as @entity417 , hypocalcaemia, and deficiencies in @entity1760 and @entity68 . No @entity8 or objective @entity16 were observed. In the follow-up of the @entity1 with BLL >= 100    g/L (19 cases). BLL monitoring showed a significant decrease in average of blood concentration ranging from 136.75      32.59 to 104.58      32.73    g/L (p  <  0.0001) and in @entity10108 prevalence (p  <  0.001), which decreased to 7.8  % from 21.1. Our study showed a high prevalence of @entity10108 (21.1  %) in EP @entity1 . The relocation of the industrial site associated with corrective and preventive measures has contributed to a decrease of exposure and @entity10108 prevalence in the aforementioned population.

title: Screening for Childhood @entity10108 in the Industrial Region of XXXX , Morocco.

answer: @entity15164 :: (389549,Gene) :: ['Fez']


abstract: BACKGROUND: Most survival studies comparing non-radical resections to bypass surgery in @entity1 with @entity788 often do not differentiate between an R1 and R2 resection. The aim of this study was to evaluate whether non-radical R1 and R2 resections have better postoperative outcomes and survival compared to a palliative bypass. METHODS: A single center cohort study was performed analyzing mortality, morbidity and 1-year survival after R1 ( @entity5 cells within 1  mm from the circumferential margin), R2 and bypass surgery in @entity1 with @entity788 . For the systematic review, studies were identified comparing R1 or R2 resections with bypass, in @entity1 with @entity788 . Postoperative outcomes were compared including the cohort study. RESULTS: The cohort study (n=405) showed higher morbidity rates after R1 (n=191) and R2 (n=11) resections compared to bypass (52% and 73% vs. 34%, p  <  0.01). In-hospital mortality did not differ (overall 1.7%). 1-year survival rates were 71%, 46% and 32% after R1, R2 resection and bypass (p=0.6 between R2 and bypass). The systematic review identified 8 studies, after including the cohort study 1535 @entity1 were analyzed. Increased morbidity after R1-R2 resection (48%) compared to bypass (30-34%) was found. Median survival was 14-18 months after R1 resection vs. 9-13 months after bypass and 8.5-11.5 months after R2 resection vs. 7.5-10.7 months after bypass. CONCLUSION: An R2 resection should be avoided in @entity1 with @entity788 due to its poor prognosis. Survival benefit after an R1 resection, as compared to bypass surgery, justifies a resection despite the increased morbidity rate.

title: Non-radical resection versus bypass procedure for XXXX - A consecutive series and systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']


abstract: INTRODUCTION: The etiology of true and false @entity438 is different, but the differential X-ray contrast diagnosis could be difficult. Purpose - to detect endoscopic ultrasonography (EUS) diagnostic capability for false and true @entity438 by considering two clinical cases: With suspected stomach and @entity660 . MATERIALS AND METHODS:                 <AbstractText Label="FIRST CASE" NlmCategory="METHODS"> @entity1 , female, 50-year-old with suspected @entity75 , complicated by @entity356 . Endoscopy - acute gastric @entity1066 . X-ray - submucosal @entity356 . The @entity1 was sent to the EUS with fine-needle aspiration. SECOND CASE: @entity1 , male, 73-year-old with suspected @entity788 . Ultrasound - pancreatic cysts. Computed tomography (CT) - @entity5 of the @entity788 body. @entity438 . The @entity1 was sent to the EUS to clarify the diagnosis. RESULTS: First @entity1 EUS - anechoic rounded lesion with thick wall close to the stomach. Stomach wall layers were not differentiated above the lesion. Doppler - turbulent blood flow. EUS excluded @entity75 and proved the presence of @entity439 . CT confirmed the @entity439 . Post-operative histology - splenic artery @entity2849 , destruction of the stomach wall and pancreatic parenchyma. Second @entity1 EUS - ovoid solid-cystic lesion with thin hyperechoic "capsule." Doppler in cystic part - arterial blood flow. EUS suspected saccular @entity438 with the neck and the residual lumen. Post-operative histology - true @entity438 with @entity715 masses near the wall, pancreatic parenchyma was intact. CONCLUSION: EUS can reliably differentiate @entity438 from @entity1819 and differentiate true and false @entity439 with high probability.

title: True and false XXXX on endoscopic ultrasonography: Two-case analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'Patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreas', 'pancreatic neoplasm']

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric submucosal lesion']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['submucosal lesion', 'stomach lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm']

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic lesions']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric tumor', 'gastric bleeding']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['Celiacography - splenic artery aneurysm', 'splenic artery aneurysm']

answer: @entity438 :: (MESH:D002532,Disease) :: ['splenic artery aneurysm']


abstract: UNASSIGNED: Apoptosis is involved in many physiological processes of the ovary, such as recruitment of prenatal germ cells, follicular @entity1146 , ovulation, and luteolysis. Based on the need for the involvement of phagocytic cells to achieve apoptosis clearance and that follicular @entity1146 is triggered by weak apoptotic stimuli, we postulate that granulosa cells engullng apoptotic corpses (ACs) must carry out this macrophagic process. Since apoptosis was early defined in terms of morphological aspects, here we describe apoptosis induced by a @entity1176 analog ( @entity3086 , LA) at histological level on @entity291 granulosa cells (primary culture, CPGB, and an established cell line, BGC-1). We observed two main types of apoptosis. In type A, the whole cell or most of it is compacted into a single large AC that is then engulfed by neighboring cells or simply detached. In type B, small portions of cells, either with or without nuclear material, become ACs that are also phagocytosed. Apoptosis and homologous phagocytosis were confirmed by TUNEL and immunocytochemistry for @entity28974 and active caspase 3. Induction of apoptosis was significant in BGC-1 cells treated for 24h with 100nM LA. CPGB cells showed two types of response with different doses of LA. Fetal calf serum was necessary to find apoptosis induced by LA.

title: Apoptosis in ovarian granulosa cells of XXXX : Morphological features and clearance by homologous phagocytosis.

entities_list: @entity3086 :: ('MESH:D016729', 'Chemical') :: ['leuprolide acetate']

answer: @entity291 :: (9913,Species) :: ['cattle']


abstract: UNASSIGNED: @entity8434 is the infection by the larvae of cestode parasites belonging to the @entity12047 sensu lato species complex. Local host responses are strikingly subdued in relation to the size and persistence of these larvae, which develop within @entity1 organs as "hydatid cysts" measuring up to tens of cm in diameter. In a context in which helminth-derived immune-suppressive, as well as Th2-inducing, molecules garner much interest, knowledge on the interactions between @entity12047 molecules and the immune system lags behind. Here we discuss what is known and what are the open questions on @entity12047 molecules and structures interacting with the innate and adaptive immune systems, potentially or in demonstrated form. We attempt a global biological approach on molecules that have been given consideration primarily as protective (Eg95) or diagnostic antigens (antigen B, antigen 5). We integrate glycobiological information, which traverses the discussions on antigen 5, the mucin-based protective laminated layer and immunologically active preparations from protoscoleces. We also highlight some less well known molecules that appear as promising candidates to possess immune-regulatory activities. Finally, we point out gaps in the molecular-level knowledge of this infectious agent that hinder our understanding of its immunology. This article is protected by copyright. All rights reserved.

title: Parasite molecules and host responses in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity8434 :: ('MESH:D004443', 'Disease') :: ['Cystic echinococcosis']

entities_list: @entity12047 :: ('6210', 'Species') :: ['E. granulosus', 'Echinococcus granulosus']

answer: @entity8434 :: (MESH:D004443,Disease) :: ['cystic echinococcosis']


abstract: BACKGROUND _ PURPOSE: In this work, we demonstrate @entity26 extraction fraction (OEF) measurement using 7T MRI with susceptibility-weighted imaging (SWI), in sedated and nonsedated adults. METHODS: Ten healthy subjects (30.3    4.5 years, 9 @entity1 , 1 @entity1 ) formed control (n = 5) and sedation groups (n = 5). @entity1363 and @entity1875 injection was administered to the same sedation group subjects during 2 different scanning sessions. Two-dimensional SPGR imaging was performed before, during, and twice after ( @entity1875 , +10, +30 minutes; @entity1363 , +10, +40 minutes) conscious sedation. The equivalent procedure was performed with the control group without sedation. After SWI analysis, change in OEF between scans was quantified, and parcelated   OEF maps were generated with 77 gray matter (GM)-containing volumes-of-interest (VOIs). RESULTS: Significant decreases in OEF were shown in 14 GM VOIs during sedation relative to the control group, most notably during @entity1363 sedation (P < .05). In contrast, no significant decrease was observed after 10 minutes and in only 4 VOIs after 40 minutes recovery. CONCLUSION: Significant change in   OEF during conscious sedation using @entity1363 and @entity1875 could be measured using SWI at 7T in vivo. This may be a potentially useful approach for the noninvasive assessment of OEF in the brain on a clinical basis.

title: Susceptibility-Weighted Phase Imaging and XXXX Extraction Fraction Measurement during Sedation and Sedation Recovery using 7T MRI.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam', 'Midazolam']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['Oxygen']


abstract: Case 1. A 48-year-old @entity1 with no history of @entity101 was referred to our hospital with a 1 cm @entity150 . According to cystoscopy, magnetic resonance imaging and 131I-MIBG scintigraphy, we diagnosed it as a @entity1494 . Partial cystectomy was performed. The histological findings supported the diagnosis of @entity1494 . Six years later, he was free of any evidence of recurrence. Case 2. A 64-year-old @entity1 with @entity101 was pointed out to have a 1cm bladder mass by ultrasound in a health examination. She was referred to our hospital for further examination. Cystoscopoy revealed a 1 cm intramural nodule covered by intact urothelium at the right posterior wall. @entity150 was not diagnosed as @entity1823 by cold punch biopsy. So, transurethral resection of the @entity150 was performed for differential diagnosis. The @entity5 was hypervascular and involved the muscular layer of the bladder. Although a transient elevation of blood pressure occurred during the procedure, the @entity5 was resected as completely as possible. The histological diagnosis was @entity1494 . She has been followed up for 27 months after operation without any evidence of recurrence.

title: [ XXXX : two case reports].

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['paraganglioma of the bladder']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor', 'Submucosal bladder tumor']

entities_list: @entity1823 :: ('MESH:D010235', 'Disease') :: ['paraganglioma']

answer: @entity1494 :: (MESH:D001745,Disease) :: ['Paraganglioma of the bladder']


abstract: A 94-year-old @entity1 visited a local urological clinic in January 2011 complaining of @entity3833 that lasted for a month. Clinical examination showed a @entity1410 -like @entity5 at the external urethral meatus. She refused an operation. After 2 months, the @entity5 became @entity548 and she was referred to our hospital for operation. A black @entity5 of fingertip-size was seen at the external urethral meatus. Urinary sediment examination and urine cytology revealed @entity320 cells. The @entity5 showed T1WI high intensity, and T2WI low intensity by magnetic resonance imaging. Collectively, the @entity1 was diagnosed with @entity320 . The @entity5 was extirpated. Pathological diagnosis showed @entity320 . However, additional therapy was not performed due to her age and thereafter, the @entity1 was followed up carefully. After 3 months, right inguinal LN swelled, and @entity5 recurred at the external urethral meatus. She died from multiple metastases 11 months from the initial consultation. We herein report this case of primary @entity320 of the female urethra in an elderly @entity1 .

title: [A case of primary XXXX of the female urethra at age 94 : a case report].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic']

entities_list: @entity3833 :: ('MESH:D053159', 'Disease') :: ['dysuria and vulvar discomfort']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['malignant melanoma', 'malignant nodular melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma']


abstract: In 147 cases of @entity189 , 388 serial mammographies were performed before final treatment. The average retrospective observation time was 27 months with a range of two months to 11 years. The number of serial mammographies per case ranged between two and 11. The @entity5 volume doubling times (TV); obtained by measuring the growth of the @entity5 nucleus shadow in the mammographies, ranged from 44 to 1869 days with an average of 212 days. No correlation between volume doubling time and histologic differentiation could be found. One hundred of these @entity5 @entity1 were found in a screening population of 22,000 @entity1 receiving serial mammographies in a time period ranging from two to 16 years. An additional 40 @entity5 @entity1 surfaced in this group without roentgenologic but with foregoing clinical or thermographic abnormalities before final diagnosis. An additional 21 @entity5 @entity1 surfaced without any @entity854 . The follow-up @entity5 ranged between three months and two years with a mean time of one year and nine months. Not considering @entity5 size, pathologic-thermographic signs appeared with greater frequency the faster the @entity5 grew. Theoretically, an average of more than 16 years should elapse before an initial @entity5 cell develops into a 10-mm primary @entity189 (30 doubling times). Therefore the length of time necessary for a 2-mm @entity5 to grow to a size of 10-mm is, on the average, four years.

title: Growth rate of 147 mammary XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['foregoing abnormalities']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['mammary carcinoma']

answer: @entity189 :: (MESH:D002277,Disease) :: ['carcinomas']


abstract: OBJECTIVE: To characterize a sample of Brazilian @entity1 with @entity6602 ( @entity6602 ) diagnosed between 1992 and 2011. METHODS: In this retrospective study, @entity1 were identified through a national reference laboratory for the diagnosis of @entity6602 and through contact with other medical genetics services across Brazil. Data were collected by means of a chart review. RESULTS: Eighty-three @entity1 from 75 families were enrolled in the study (median age, 3 years; interquartile range [IQR], 0.57-7). Median age at onset of symptoms was 10 days (IQR 5-30), whereas median age at diagnosis was 60 days (IQR 29-240, p=0.001). Only three (3.6%) @entity1 were diagnosed before the onset of clinical manifestations. A comparison between @entity1 with (n=12) and without (n=71) an early diagnosis shows that early diagnosis is associated with the presence of positive family history and decreased prevalence of clinical manifestations at the time of diagnosis, but not with a better outcome. Overall, 98.8% of @entity1 have some @entity245 . CONCLUSION: In Brazil, @entity1 with @entity6602 are usually diagnosed late and exhibit @entity16 and poor survival even with early diagnosis. We suggest that specific public policies for diagnosis and treatment of @entity6602 should be developed and implemented in the country.

title: XXXX in Brazil: a panorama of the last two decades.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological involvement']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['psychomotor or neurodevelopmental delay']

entities_list: @entity6602 :: ('MESH:D008375', 'Disease') :: ['maple syrup urine disease', 'MSUD']

answer: @entity6602 :: (MESH:D008375,Disease) :: ['Maple Syrup Urine Disease']


abstract: Objectives. The aim of this study was to determine prognostic factors in @entity1 with well-differentiated @entity259 (WDTC).Methods. This retrospective study included 181 well-differentiated @entity259 @entity1 who were operated between Decembers 1996-2007. Total of 181 @entity1 [139 (76.8%) @entity1 and 42 (23.2%) @entity1 with a  mean age of 46.3 years] who were subjected to a  complete follow-up, were enrolled in the study. The mean follow-up period was 7.1 years (range 3.1 to 14.9 years). Medical records were reviewed regarding to age, gender, extent of surgery, @entity5 size, multifocality, clinical stage, capsule infiltration, extracapsular invasion, histological type, lymph node @entity3 , distant @entity3 , radioactive @entity1496 treatment and prognosis.Results. During follow-up, in 41 (22.6%) @entity1 locoregional recurrences were detected and 5 (2.7%) @entity1 passed away. Determined statistically significant prognostic factors were as follows; @entity5 size (histopathologically), extent of surgery, histological type, lymph node @entity3 , @entity5 invasion (capsule and extracapsular) and clinical stage.Conclusions. Well-differentiated @entity259 is a  disease with good prognosis when detected early and appropriate treatment applied. Despite the prognosis, it is good to apply the right treatment and reduce recurrence and mortality rates, prognostic factors are well known and must be considered in @entity1 management. KEYWORDS: @entity259 ; prognostic factors; thyroidectomy.

title: Prognostic factors of survival and recurrence pattern in differentiated XXXX : A retrospective study from Western Turkey.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']

answer: @entity259 :: (MESH:D013964,Disease) :: ['thyroid cancer']


abstract: UNASSIGNED: During development, @entity2042 undergoes many morphological and physiological transformations as a result of profound changes in gene expression. Proteins containing @entity219 finger motifs usually play an important role in DNA recognition, RNA packaging, and transcriptional activation. In our current study, we cloned the open reading frame (ORF) of SjZFP1 of @entity2043 , which encodes a @entity219 finger protein. We analyzed the complementary DNA (cDNA) sequence of SjZFP1 and examined the expression of SjZFP1 messenger RNA (mRNA) at various developmental stages. We also tested the effects of RNA interference (RNAi) silencing on worm burden, spawning, and egg hatching. The ORF in the SjZFP1 cDNA was 1017  bp in length and was predicted to encode a 338-aa protein with a molecular mass of approximately 38.5  kDa and theoretical isoelectric point (pI) of 7.08. Several conserved regions, including a B-box-type @entity219 -binding domain, two bipartite nuclear localization signal domains, a paired amphipathic helix repeat, and overlapping RING and PHD finger domains, were identified in the predicted @entity535 sequence of SjZFP1. Using real-time PCR, we showed that the SjZFP1 mRNA was expressed across all of the developmental stages of the parasite and that the level of transcription was highest in the cercariae, eggs, schistosomula, and mature adult worms. The level of SjZFP1 mRNA expression in cultured schistosomula treated with one of two SjZFP1-specific small interfering RNAs (siRNAs; AY770 and AY546) was reduced by over 80  %, compared with that in the controls. In RNAi experiments in BALB/c @entity19 , the level of SjZFP1 mRNA increased significantly when the @entity19 were treated with the same SjZFP1-specific siRNAs during the early stages of infection. By contrast, the level of SjZFP1 mRNA decreased significantly when the @entity19 were treated with the SjZFP1-specific siRNAs during the middle to late stages of infection. In four independent experiments, fewer worms were recovered from @entity19 treated with the SjZFP1-specific siRNAs, compared with the number of worms recovered from the control @entity19 . Both the average number and hatching rates of liver eggs recovered from @entity19 treated with the SjZFP1-specific siRNAs during the middle to late stages of infection were significantly lower than those of the liver eggs recovered from the control @entity19 . Our results suggest that the SjZFP1 gene might be important for parasite development, spawning in the vertebrate host, and egg hatching.

title: The molecular characterization and RNAi silencing of SjZFP1 in XXXX .

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity2042 :: ('6182', 'Species') :: ['Schistosoma japonicum']

answer: @entity2042 :: (6182,Species) :: ['Schistosoma japonicum']


abstract: BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is currently being widely accepted for its role in the treatment of morbid @entity28 . Staple-line leakage is one of the most reported complications found in 0.5-7  % of the population, in which the Over-the-Scope @entity23396 (OTSC) (Ovesco Endoscopy, T  bingen, Germany), a novel device, is employed. We present our experience with this system in LSG leaks. METHODS: A retrospective analysis of prospectively collected data from @entity1 with LSG leakage was performed, and these @entity1 were treated with the OTSC system. Efficiency was defined as complete oral nutrition without any evidence of additional leakage. RESULTS: Overall, 26 @entity1 underwent endoscopic OTSC treatment. The median age was 39  years (range 26-60), and 12 were male @entity1 (46.15  %). The mean body mass index (BMI) was 42.89  kg/m(2), and 10 @entity1 (38.46  %) came from a revisional bariatric procedure (SRVG or LAGB). Twenty-two @entity1 (84.61  %) had upper staple-line leaks (near the GEJ), and the remaining 4 (15.38  %) had lower antral leaks. Number of endoscopy sessions ranged from 2 to 7 (median 3). There were five failures: 2 of them had an antral leak, and the remaining 3 had an upper staple-line leak. Twenty-one (80.76  %) leaks were successfully treated within 32  days' median time till complete oral nutrition was attained (range 14-70). CONCLUSIONS: The success rate was high with the OTSC system, and it is concluded to be a safe and effective treatment for LSG leaks.

title: Over-the-Scope XXXX (OTSC) System for Sleeve Gastrectomy Leaks.

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity23396 :: (6249,Gene) :: ['Clip']


abstract: UNASSIGNED: Polar lipids of bacteria from the class Thermomicrobia are known to contain long-chain 1,2-diols instead of @entity653 , although the nature of polar head groups has not been investigated. We have studied phospholipid classes of two species from the class Thermomicrobia- @entity5859 and Thermomicrobia sp. WKT50.2. TLC and @entity9715 -NMR analysis of polar lipids revealed that both @entity5859 and Thermomicrobia sp. WKT50.2 contain the same set of four major phospholipid classes. Structures of the novel phospholipids in @entity5859 were established as 2-acylalkyldiol-1-O-phosphoinositol, 2-acylalkyldiol-1-O-phosphoinositol mannoside, 2-acylalkyldiol-1-O-phospho-acylmannoside, and 2-acylalkyldiol-1-O-phosphoinositol acylmannoside. To our knowledge, this is the first report of a phospholipid with a @entity3913 directly bound to the @entity1391 . We also analyzed @entity1718 and long-chain 1,2-diols of @entity5859 and Thermomicrobia sp. WKT50.2 and compared our data with available information for @entity71724 . All species share a similar set of @entity1718 , with 12-Me 18:0 being the major @entity844 . The major @entity27716 in @entity5859 was identified as 13-Me 19:0 (66.2  %). The 21:0 @entity27716 was the major component both in Thermomicrobia sp. WKT50.2 (50.6  %) and in @entity71724 (56.6  %).

title: Novel Long-Chain XXXX Phospholipids from Some Bacteria Belonging to the Class Thermomicrobia.

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity5859 :: ('2057', 'Species') :: ['S.  thermophilus', 'Sphaerobacter thermophilus', 'S. thermophilus']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

answer: @entity27716 :: (CHEBI:23824,Chemical) :: ['Diol']


abstract: UNASSIGNED: Free radical polymerization is often used to prepare protein and peptide-loaded hydrogels for the design of controlled release systems and molecular imprinting materials. Peroxodisulfates (ammonium peroxodisulfates (APS) or potassium peroxodisulfates (KPS)) with @entity71725 ( @entity71725 ) are frequently used as initiator and catalyst. However, exposure to these free radical polymerization reagents may lead to modification of the protein and peptide. In this work, we show the modification of @entity376 residues by ammonium peroxodisulfate (APS)/TEMED of the immunostimulant @entity36808 (TP5). Parallel studies on a decapeptide and a library of 15 @entity9881 were performed to reveal the mechanism of modification. LC-MS of APS/TEMED-exposed TP5 revealed a major reaction product with an increased mass (+12 Da) with respect to TP5. LC-MS(2) and LC-MS(3) were performed to obtain structural information on the modified peptide and localize the actual modification site. Interpretation of the obtained data demonstrates the formation of a @entity845 bridge between the @entity376 and @entity369 residue in the presence of TEMED, while replacing TEMED with a @entity4389 catalyst did not show this modification. Studies with the other peptides showed that the TEMED radical can induce methyleneation on peptides when @entity376 is next to @entity369 , @entity1521 , @entity462 , aspargine, @entity1160 , @entity3793 , @entity669 , @entity2340 , and @entity2574 residues. Stability of peptides and protein needs to be considered when using APS/TEMED in in situ polymerization systems. The use of an alternative catalyst such as @entity4389 may preserve the chemical integrity of peptides during in situ polymerization.

title: Methyleneation of Peptides by XXXX (TEMED) under Conditions Used for Free Radical Polymerization: A Mechanistic Study.

entities_list: @entity2574 :: ('CHEBI:22660', 'Chemical') :: ['aspartic acid']

entities_list: @entity462 :: ('MESH:D003545', 'Chemical') :: ['cysteine']

entities_list: @entity845 :: ('CHEBI:29358', 'Chemical') :: ['methylene']

entities_list: @entity36808 :: ('MESH:D016305', 'Chemical') :: ['thymopentin']

entities_list: @entity1160 :: ('CHEBI:28300', 'Chemical') :: ['glutamine']

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

entities_list: @entity3793 :: ('CHEBI:27570', 'Chemical') :: ['histidine']

entities_list: @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

entities_list: @entity71725 :: ('MESH:C005798', 'Chemical') :: ['TEMED', 'N,N,N,N-tetramethylethylenediamine']

entities_list: @entity4389 :: ('MESH:C009279', 'Chemical') :: ['sodium bisulfite']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity9881 :: ('MESH:D004151', 'Chemical') :: ['dipeptides']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity71725 :: (MESH:C005798,Chemical) :: ['N,N,N,N-Tetramethylethylenediamine']


abstract: PURPOSE: To evaluate the ability of longitudinal Useful Field of View (UFOV) and simulated driving measurements to predict future occurrence of @entity1957 ( @entity1957 ) in drivers with @entity726 . DESIGN: Prospective observational cohort study. @entity1 : 117 drivers with @entity726 followed for an average of 2.1    0.5 years. METHODS: All subjects had standard automated perimetry (SAP), UFOV, driving simulator, and cognitive assessment obtained at baseline and every 6 months during follow-up. The driving simulator evaluated reaction times to high and low contrast peripheral divided attention stimuli presented while negotiating a winding country road, with central driving task performance assessed as "curve coherence". Drivers with @entity1957 during follow-up were identified from Department of Motor Vehicle records. MAIN OUTCOME MEASURES: Survival models were used to evaluate the ability of driving simulator and UFOV to predict @entity1957 over time, adjusting for potential confounding factors. RESULTS: Mean age at baseline was 64.5    12.6 years. 11 of 117 (9.4%) drivers had a @entity1957 during follow-up. In the multivariable models, low contrast reaction time was significantly predictive of @entity1957 , with a hazard ratio (HR) of 2.19 per 1 SD slower reaction time (95% CI, 1.30 to 3.69; P = 0.003). UFOV divided attention was also significantly predictive of @entity1957 with a HR of 1.98 per 1 SD worse (95% CI, 1.10 to 3.57; P = 0.022). @entity2194 were not predictive of @entity1957 . The longitudinal model including driving simulator performance was a better predictor of @entity1957 compared to UFOV (R2 = 0.41 vs R2 = 0.18). CONCLUSIONS: Longitudinal divided attention metrics on the UFOV test and during simulated driving were significantly predictive of risk of @entity1957 in @entity726 @entity1 . These findings may help improve the understanding of factors associated with driving impairment related to @entity726 .

title: Predicting Risk of Motor Vehicle Collisions in @entity1 with XXXX : A Longitudinal Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity1957 :: ('MESH:D019957', 'Disease') :: ['MVC', 'motor vehicle collision']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['Global SAP visual field indices in the better or worse eye']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

answer: @entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']


abstract: PURPOSE: To evaluate the ability of longitudinal Useful Field of View (UFOV) and simulated driving measurements to predict future occurrence of @entity1957 ( @entity1957 ) in drivers with @entity726 . DESIGN: Prospective observational cohort study. @entity1 : 117 drivers with @entity726 followed for an average of 2.1    0.5 years. METHODS: All subjects had standard automated perimetry (SAP), UFOV, driving simulator, and cognitive assessment obtained at baseline and every 6 months during follow-up. The driving simulator evaluated reaction times to high and low contrast peripheral divided attention stimuli presented while negotiating a winding country road, with central driving task performance assessed as "curve coherence". Drivers with @entity1957 during follow-up were identified from Department of Motor Vehicle records. MAIN OUTCOME MEASURES: Survival models were used to evaluate the ability of driving simulator and UFOV to predict @entity1957 over time, adjusting for potential confounding factors. RESULTS: Mean age at baseline was 64.5    12.6 years. 11 of 117 (9.4%) drivers had a @entity1957 during follow-up. In the multivariable models, low contrast reaction time was significantly predictive of @entity1957 , with a hazard ratio (HR) of 2.19 per 1 SD slower reaction time (95% CI, 1.30 to 3.69; P = 0.003). UFOV divided attention was also significantly predictive of @entity1957 with a HR of 1.98 per 1 SD worse (95% CI, 1.10 to 3.57; P = 0.022). @entity2194 were not predictive of @entity1957 . The longitudinal model including driving simulator performance was a better predictor of @entity1957 compared to UFOV (R2 = 0.41 vs R2 = 0.18). CONCLUSIONS: Longitudinal divided attention metrics on the UFOV test and during simulated driving were significantly predictive of risk of @entity1957 in @entity726 @entity1 . These findings may help improve the understanding of factors associated with driving impairment related to @entity726 .

title: Predicting Risk of Motor Vehicle Collisions in XXXX with @entity726 : A Longitudinal Study.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: We describe a protocol for the insertion of ultrashort single-walled @entity505 nanotubes (SWCNTs) to form nanopores in a Montal-Mueller lipid bilayer. The SWCNTs are designed to bind to a specific analyte of interest; binding will result in the reduction of current in single-channel recording experiments. The first stage of the PROCEDURE is to cut and separate the SWCNTs. We cut long, purified SWCNTs with sonication in concentrated @entity8316 / @entity32428 (3/1). Isolation of ultrashort SWCNTs is carried out by size-exclusion @entity1172 . The second stage is to insert these short SWCNTs into the lipid bilayer. This step requires a microinjection probe made from a glass capillary. The setup for protein nanopore research can be adopted for the single-channel recording experiments without any special treatment. The obtained current traces are of very high quality, showing stable baselines and little background noise. Example procedures are shown for investigating ion transport and DNA translocation through these SWCNT nanopores. This nanopore has potential applications in molecular sensing, nanopore DNA sequencing and early disease diagnosis. For example, we have selectively detected modified @entity54926 in single-stranded DNA (ssDNA), which may have implications in screening specific genomic DNA sequences. The protocol takes    15 d, including SWCNT purification, cutting and separation, as well as the formation of SWCNT nanopores for DNA analyses.

title: Fabrication of nanopores with ultrashort single-walled XXXX nanotubes inserted in a lipid bilayer.

entities_list: @entity8316 :: ('MESH:C033158', 'Chemical') :: ['sulfuric acid']

entities_list: @entity32428 :: ('MESH:D017942', 'Chemical') :: ['nitric acid']

entities_list: @entity1172 :: ('MESH:D001010', 'Disease') :: ['HPLC separation']

entities_list: @entity54926 :: ('MESH:C011865', 'Chemical') :: ['5-hydroxymethylcytosine']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['carbon']


abstract: UNASSIGNED: Chloroquine-primaquine (CQ-PQ) continues to be the frontline therapy for radical cure of @entity3965 @entity311 . Emergence of CQ-resistant (CQR) @entity3965 parasites requires shifting to @entity507 combination therapies (ACTs), which imposes a significant financial, logistical, and safety burden. Monitoring therapeutic efficacy of CQ is thus important. Here we evaluated therapeutic efficacy of CQ-PQ for @entity3965 @entity311 in northeast Myanmar. We recruited 587 @entity1 with @entity3965 mono- @entity281 attending local @entity311 clinics during 2012-2013. These @entity1 received three daily doses of CQ at a total dose of 24 mg base/kg body weight and an 8-day PQ treatment (0.375 mg/kg/day) commencing at the same time as first CQ dose. Of the 401 @entity1 who finished 28-day follow-up, the cumulative incidence of recurrent @entity5895 was 5.20% (95% CI, 3.04%-7.36%). Among 361 (61%) @entity1 finishing 42-day follow-up, the cumulative incidence of recurrent blood stage @entity281 reached 7.98% (95% CI, 5.20%-10.76%). The cumulative risk of gametocyte carriage at day 28 and 42 was 2.21% (95% CI, 0.78%-3.64%) and 3.93% (95% CI, 1.94%-5.92%), respectively. Interestingly, all 15 @entity1 with recurrent gametocytemias were associated with concurrent asexual stages. Genotyping of recurrent parasites at the merozoite surface protein 3a locus among 12 @entity1 with recurrent @entity5895 within 28 days revealed that 10 of these were the same genotype as day 0, suggesting of recrudescence or relapse. Similar studies in 70 @entity1 in the same area in 2007 showed no recurrent @entity5895 within 28 days. Sensitivity to @entity503 of @entity3965 in northeastern Myanmar may be deteriorating.

title: Therapeutic Responses of @entity3965 Malaria to XXXX and Primaquine Treatment in Northeastern Myanmar.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3965 :: ('5855', 'Species') :: ['P. vivax', 'Plasmodium vivax']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity507 :: ('MESH:C031327', 'Chemical') :: ['artemisinin']

entities_list: @entity5895 :: ('MESH:D018512', 'Disease') :: ['parasitemia', 'parasitemias']

entities_list: @entity503 :: ('MESH:D002738', 'Chemical') :: ['chloroquine']

answer: @entity503 :: (MESH:D002738,Chemical) :: ['Chloroquine']


abstract: UNASSIGNED: Chloroquine-primaquine (CQ-PQ) continues to be the frontline therapy for radical cure of @entity3965 @entity311 . Emergence of CQ-resistant (CQR) @entity3965 parasites requires shifting to @entity507 combination therapies (ACTs), which imposes a significant financial, logistical, and safety burden. Monitoring therapeutic efficacy of CQ is thus important. Here we evaluated therapeutic efficacy of CQ-PQ for @entity3965 @entity311 in northeast Myanmar. We recruited 587 @entity1 with @entity3965 mono- @entity281 attending local @entity311 clinics during 2012-2013. These @entity1 received three daily doses of CQ at a total dose of 24 mg base/kg body weight and an 8-day PQ treatment (0.375 mg/kg/day) commencing at the same time as first CQ dose. Of the 401 @entity1 who finished 28-day follow-up, the cumulative incidence of recurrent @entity5895 was 5.20% (95% CI, 3.04%-7.36%). Among 361 (61%) @entity1 finishing 42-day follow-up, the cumulative incidence of recurrent blood stage @entity281 reached 7.98% (95% CI, 5.20%-10.76%). The cumulative risk of gametocyte carriage at day 28 and 42 was 2.21% (95% CI, 0.78%-3.64%) and 3.93% (95% CI, 1.94%-5.92%), respectively. Interestingly, all 15 @entity1 with recurrent gametocytemias were associated with concurrent asexual stages. Genotyping of recurrent parasites at the merozoite surface protein 3a locus among 12 @entity1 with recurrent @entity5895 within 28 days revealed that 10 of these were the same genotype as day 0, suggesting of recrudescence or relapse. Similar studies in 70 @entity1 in the same area in 2007 showed no recurrent @entity5895 within 28 days. Sensitivity to @entity503 of @entity3965 in northeastern Myanmar may be deteriorating.

title: Therapeutic Responses of XXXX Malaria to @entity503 and Primaquine Treatment in Northeastern Myanmar.

answer: @entity3965 :: (5855,Species) :: ['Plasmodium vivax']


abstract: BACKGROUND: United States and European cardiovascular society guidelines recommend physicians counsel @entity1 about resuming sexual activity after @entity583 ( @entity583 ), but little is known about @entity1 ' experience with counseling about sexual activity after @entity583 . METHODS AND RESULTS: The prospective, longitudinal Variation in Recovery: Role of Gender on Outcomes of Young @entity583 @entity1 (VIRGO) study, conducted at 127 hospitals in the United States and Spain, was designed, in part, to evaluate gender differences in baseline sexual activity, function, and @entity1 experience with physician counseling about sexual activity after an @entity583 . This study used baseline and 1-month data collected from the 2:1 sample of @entity1 (N=2349) and @entity1 (N=1152) ages 18 to 55 years with @entity583 . Median age was 48 years. Among those who reported discussing sexual activity with a physician in the month after @entity583 (12% of @entity1 , 19% of @entity1 ), 68% were given restrictions: limit sex (35%), take a more passive role (26%), and/or keep the heart rate down (23%). In risk-adjusted analyses, factors associated with not discussing sexual activity with a physician included female gender (relative risk, 1.07; 95% confidence interval, 1.03-1.11), age (relative risk, 1.05 per 10 years; 95% confidence interval, 1.02-1.08), and sexual inactivity at baseline (relative risk, 1.11; 95% confidence interval, 1.08-1.15). Among @entity1 who received counseling, @entity1 in Spain were significantly more likely to be given restrictions than U.S. @entity1 (relative risk; 1.36, 95% confidence interval, 1.11-1.66). CONCLUSIONS: Very few @entity1 reported counseling for sexual activity after @entity583 . Those who did were commonly given restrictions not supported by evidence or guidelines. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00597922.

title: Sexual activity and counseling in the first month after XXXX among younger adults in the United States and Spain: a prospective, observational study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'men']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']


abstract: STUDY DESIGN: Retrospective cohort. OBJECTIVE: The purpose of this study was to compare outcomes of surgical treatment of @entity3799 between smokers and nonsmokers as assessed by the Nurick score. SUMMARY OF BACKGROUND DATA: The harmful effects of smoking on healing have been well established. However, the effect of smoking on postoperative outcomes for @entity3799 has not been specifically evaluated. METHODS: The medical records of 212 @entity1 who underwent surgery for cervical @entity602 were reviewed. Inclusion criteria were the diagnosis of cervical @entity602 with a Nurick score, surgical intervention, and at least 2 years of follow-up. The @entity1 were categorized into 2 groups according to smoking status and stratified according to pack years and packs per day. Age at presentation, sex, preoperative and postoperative Nurick score, duration of symptoms preoperatively, duration of follow-up, procedure performed, surgical approach, number of levels fused, @entity6 status, @entity2072 use, @entity1068 use, preoperative magnetic resonance imaging signal change, and whether the @entity1 belonged to the Veterans Administration (VA) were recorded. Analysis was done using simple linear regression and multiple regression. RESULTS: Univariate analysis demonstrated a postoperative improvement in nonsmokers of 1.53 points on the Nurick scale compared with 0.6 points in smokers (P < 0.001). There is a progressive decrease in improvement as the number of pack years and packs per day increase (P < 0.001). There is a greater improvement in Nurick score with greater (worse) preoperative score but only in @entity1 with fewer than 25 pack years. Smoking status is not associated with preoperative Nurick score. CONCLUSION: Smoking status is associated with poor improvement in Nurick score after surgical treatment of @entity3799 . Smoking may have a directly toxic effect on the intrinsic healing capability of the spinal cord, particularly beyond 25 pack years. LEVEL OF EVIDENCE: 3.

title: The Effect of Smoking on Spinal Cord Healing Following Surgical Treatment of Cervical XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['spondylotic myelopathy']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['cervical myelopathy']

answer: @entity602 :: (MESH:D013118,Disease) :: ['Myelopathy']


abstract: OBJECTIVE: To determine clinical and radiological factors that predict the successful outcome of @entity5663 ( @entity5663 ) in @entity1 with lumbar @entity3976 ( @entity3976 ). METHODS: We retrospectively reviewed the clinical and radiological features of @entity1 who underwent lumbar @entity5663 from April 2009 to March 2013. Sixty-nine @entity1 with lumbar @entity3976 were studied. Clinical outcome was assessed by the visual analogue scale (VAS) and the @entity717 Index (ODI). Multivariate logistic regression analysis was performed to assess relationship among clinical and radiological factors and the successful outcome of the @entity5663 . RESULTS: The VAS and the ODI decreased significantly at 1 year follow-up (p<0.01). One year after @entity5663 , the reduction of the VAS (  VAS) was significantly greater in the @entity1 with @entity158 for <6 months (p=0.03) and subarticular @entity3976 (p=0.015). The reduction of the ODI (  ODI) was significantly greater in the @entity1 with high intensity zone (p=0.04). Multivariate logistic regression analysis revealed the following 5 factors that were associated with the successful outcome after @entity5663 : @entity158 duration for <6 months (odds ratio [OR]=14.036; p=0.006), positive straight leg raising test (OR=8.425, p=0.014), the extruded @entity3976 (OR=0.106, p=0.04), the sequestrated @entity3976 (OR=0.037, p=0.026), and the subarticular @entity3976 (OR=10.876, p=0.012). CONCLUSION: @entity5663 provided significant improvement of @entity158 and disability of @entity1 . The results of the analysis indicated that the duration of @entity158 <6 months, positive straight leg raising test, the subarticular @entity3976 , and the protruded @entity3976 were predicting factors associated with the successful response of @entity5663 in @entity1 with lumbar @entity3976 .

title: The Factors Associated With the Successful Outcomes of Percutaneous Disc Decompression in XXXX With Lumbar Herniated Nucleus Pulposus.

entities_list: @entity3976 :: ('MESH:D004677', 'Disease') :: ['herniated nucleus pulposus', 'HNP']

entities_list: @entity5663 :: ('MESH:D003665', 'Disease') :: ['PDD', 'percutaneous disc decompression']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: RATIONALE: Annual low-radiation-dose computed tomography (LDCT) screening for @entity2 has been shown to reduce @entity2 mortality among high-risk individuals and is now recommended by multiple organizations. However, LDCT screening is complex, and implementation requires careful planning to ensure benefits outweigh harms. Little guidance has been provided for sites wishing to develop and @entity2 screening programs. OBJECTIVES: To promote successful implementation of comprehensive LDCT screening programs that are safe, effective, and sustainable. METHODS: The American @entity1514 Society (ATS) and American College of Chest Physicians (ACCP) convened a committee with expertise in @entity2 screening, pulmonary nodule evaluation, and implementation science. The committee reviewed the evidence from systematic reviews, clinical practice guidelines, surveys, and the experience of early-adopting LDCT screening programs and summarized potential strategies to implement LDCT screening programs successfully. MEASUREMENTS AND MAIN RESULTS: We address steps that sites should consider during the main three phases of developing an LDCT screening program: planning, implementation, and maintenance. We present multiple strategies to implement the nine core elements of comprehensive @entity2 screening programs enumerated in a recent ACCP/ATS statement, which will allow sites to select the strategy that best fits with their local context and workflow patterns. Although we do not comment on cost-effectiveness of LDCT screening, we outline the necessary costs associated with starting and sustaining a high-quality LDCT screening program. CONCLUSIONS: Following the strategies delineated in this policy statement may help sites to develop comprehensive LDCT screening programs that are safe and effective.

title: An Official American XXXX Society/American College of Chest Physicians Policy Statement: Implementation of Low-Dose Computed Tomography Lung Cancer Screening Programs in Clinical Practice.

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'implement lung cancer']

answer: @entity1514 :: (MESH:D013896,Disease) :: ['Thoracic']


abstract: OBJECTIVE: @entity1702 ( @entity1702 ) are widely used for the palliative management of malignant proximal gastroduodenal obstruction because of its low morbidity and mortality rates compared with surgical bypass. However, stent placement for @entity9727 beyond the first part of the duodenum is considered technically difficult and is not routinely performed. We report our experience with @entity1702 placement for these @entity1 . METHODS: Between 2006 and 2015, 51 @entity1 with unresectable or metastatic malignancy underwent @entity1702 placements under combined endoscopic and fluoroscopic guidance. Eighteen @entity1 had @entity1321 distal to the duodenal bulb. Their demographics, technical and clinical outcomes, periprocedural morbidity and mortality, length of hospital stay, further interventions and overall survival were analysed. RESULTS: Out of the 18 cases, nine cases of @entity1321 were due to primary @entity5 , three due to @entity356 , three from other @entity5 and three were the result of @entity3 . In 12 @entity1 , the obstruction involved the second part (D2), in four the third part (D3) and in two the fourth part (D4) of the duodenum. A front-facing therapeutic gastroscope was used to visualize the duodenum before the stricture was crossed under direct vision and fluoroscopic guidance, with a catheter and guidewire, and a through-the-scope @entity1702 deployed using an 'over-the-wire' technique. Technical success rate was 89%. The mean gastric outlet obstruction scores improved from 0.63 to 2.57 (P<0.0001). Four @entity1 died within 30 days of the procedure, although none of the deaths were procedure related. The median length of postprocedural hospital stay was 4 days and the median overall survival was 58 days.

title: Self-expandable metal stent placement for XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['locoregional cancers', 'malignancy of the pancreas']

entities_list: @entity9727 :: ('MESH:D004380', 'Disease') :: ['duodenal obstruction']

entities_list: @entity1702 :: ('MESH:D013651', 'Disease') :: ['Self-expandable metal stents', 'SEMS']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric malignancy']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignant duodenal obstruction distal to the bulb']


abstract: UNASSIGNED: This study aimed to investigate the influence of the "good-old-days" bias, neuropsychological functioning and cued recall of life events on self-concept change. Forty seven adults with @entity131 (70% male, 1-5 years post-injury) and 47 matched controls rated their past and present self-concept on the @entity542 Semantic Differential Scale (HISD) III. @entity131 @entity1 also completed a battery of neuropsychological tests. The matched control group of 47 were from a sample of 78 uninjured @entity1 who were randomised to complete either the Social Readjustment Rating Scale-Revised (cued recall) or HISD (non-cued recall) first. Consistent with the good-old-days bias, @entity1 with @entity131 rated their pre-injury self-concept as more positive than their present self-concept and the present self-concept of controls (p   <   .05). More positive pre-injury self-concept ratings were related to lower estimated premorbid IQ and poorer verbal fluency and delayed memory (p   <   .05). For uninjured @entity1 , cued recall, life events and event appraisals each accounted for unique variance in self-concept change (p   <   .01) after controlling for negative affect. The cued recall group rated their past self-concept as significantly more negative than the non-cued group (p   <   .01). Overall, the good-old-days bias, neuropsychological functioning and cued recall influenced reports of self-concept change by affecting retrospective ratings of past self-concept. Further research is needed to investigate the impact of contextual cues on self-concept change after @entity131 .

title: A biopsychosocial investigation of changes in self-concept on the XXXX Semantic Differential Scale.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['Head Injury']

answer: @entity542 :: (MESH:D006259,Disease) :: ['Head Injury']


abstract: BACKGROUND: Misdiagnosing @entity162 can lead to very deleterious consequences of mistreatment. Although @entity308 may be similarly expressed in unipolar and @entity162 , changes in specific brain networks could be very distinct, being therefore informative markers for the differential diagnosis. We aimed to characterize specific alterations in candidate large-scale networks (frontoparietal, cingulo-opercular, and default mode) in symptomatic unipolar and @entity162 @entity1 using resting state fMRI, a cognitively low demanding paradigm ideal to investigate @entity1 . METHODS: Networks were selected after independent component analysis, compared across 40 @entity1 acutely depressed (20 unipolar, 20 @entity162 ), and 20 controls well-matched for age, gender, and education levels, and alterations were correlated to clinical parameters. RESULTS: Despite comparable symptoms, @entity1 groups were robustly differentiated by large-scale network alterations. Differences were driven in @entity162 @entity1 by increased functional connectivity in the frontoparietal network, a central executive and externally-oriented network. Conversely, unipolar @entity1 presented increased functional connectivity in the default mode network, an introspective and self-referential network, as much as reduced connectivity of the cingulo-opercular network to default mode regions, a network involved in detecting the need to switch between internally and externally oriented demands. These findings were mostly unaffected by current medication, comorbidity, and structural changes. Moreover, network alterations in unipolar @entity1 were significantly correlated to the number of @entity308 episodes. CONCLUSION: Unipolar and @entity162 groups displaying similar symptomatology could be clearly distinguished by characteristic changes in large-scale networks, encouraging further investigation of network fingerprints for clinical use. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

title: Differentiating XXXX by alterations in large-scale brain networks.

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar depression', 'bipolar disorder', 'bipolar']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'depressive']

answer: @entity162 :: (MESH:D001714,Disease) :: ['unipolar and bipolar depression']


abstract: UNASSIGNED: @entity4929 ( @entity4929 ) are characterized by the growth of epithelial components with @entity3558 production in the main pancreatic duct, or a large branch. We report a case of @entity1377 ( @entity1377 ) of the pancreatic head, complicated by pancreaticobiliary maljunction (PBM) and an aberrant pancreatic duct draining into the stomach. A 50-year-old @entity1 with malaise and @entity1087 was found to have a mass in the pancreatic head at a local hospital. He was clinically diagnosed with @entity1377 with invasion to the stomach and duodenum after extensive endoscopic and radiological evaluation and a pancreaticoduodenectomy was performed. Histologically, most of the lesion exhibited proliferation of atypical glands, with irregular papillary and villoglandular structures lined by mucinous columnar epithelium, which extended intraepithelially along the dilated pancreatic duct wall. @entity5 cells spread into the duodenal wall formed mucous nodules. The pancreatic ducts of this lesion uniquely showed two @entity600 ; PBM, and an aberrant pancreatic duct opening to the gastric wall. This case was rare in the sense that @entity1377 extended into such unique structures. We report a case of @entity1377 with rare localization. The pathogenesis of this type of @entity5 in an abnormal pancreatic duct will be discussed.

title: XXXX involving pancreaticobiliary maljunction and an aberrant pancreatic duct draining into the stomach: A case report and review of the literature.

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['IPMC', 'intraductal papillary mucinous carcinoma']

entities_list: @entity4929 :: ('MESH:C565310', 'Disease') :: ['IPMN', 'Intraductal papillary mucinous neoplasms']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations']

answer: @entity4929 :: (MESH:C565310,Disease) :: ['Intraductal papillary mucinous neoplasm']


abstract: UNASSIGNED: The surprising results published by FIRE-3 revealed that the overall survival (OS) of RAS wild-type metastatic @entity14 (mCRC) @entity1 treated with Cetuximab(Cmab) and FOLFIRI combination was prolonged to 33.1  months. The substantial increase in testing and treatment costs, however, impose a considerable health burden on @entity1 and society. Hence the study was aimed to assess the cost-effectiveness of RAS screening before monoclonal antibodies (mAbs) therapy based on FIRE-3 study. Four groups were analyzed: group 1, @entity1 with @entity984 testing treated with Cmab and FOLFIRI; group 2, @entity1 with RAS testing treated with Cmab and FOLFIRI; group 3, @entity1 with @entity984 testing treated with bevacizumab(Bmab) and FOLFIRI; group 4, @entity1 with RAS testing treated with Bmab and FOLFIRI. A Markov model comprising 3 health states (progression-free survival, progressive disease and @entity204 ) was built. The costs were calculated from a Chinese payer perspective, and survival was reported in quality-adjusted life-months (QALMs). Average total lifetime costs ranged from  104,682.44 (RAS-Bmab) to  136,867.44 (RAS-Cmab), while the survival gained varied from 16.88 QALMs in RAS-Bmab to 21.85 QALMs in RAS-Cmab. The cost per QALM was  6,263.86 for RAS-Cmab,  6,145.84 for @entity984 -Bmab,  6,201.57 for RAS-Bmab and  6,960.70 for @entity984 -Cmab respectively. The @entity984 -Cmab strategy was dominated by the other 3 groups. The first-treatment cost of RAS-Cmab was the most influential one to the model. In all, the RAS screening prior to Cmab treatment in mCRC seems to be a cost-effective strategy in the time of monoclonal antibodies (mAbs) therapy with the most gained QALMs.

title: Cost-effectiveness of RAS screening before monoclonal antibodies therapy in metastatic XXXX based on FIRE3 Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: OBJECTIVE: The objective of this study was to characterize the @entity74 in two fetuses with @entity154 in prenatal screening. MATERIALS AND METHODS: The mother of Fetus 1 was 26  years old and had a second trimester serum screening that indicated the fetus was at low risk. The prenatal ultrasound and magnetic resonance imaging (MRI) at 28  weeks of gestation showed mild @entity1276 , @entity4242 , and agenesis of the @entity6789 . The mother of Fetus 2 was 25  years old and also had a second trimester serum screening that indicated the fetus was at low risk. The prenatal ultrasound at 32  weeks of gestation showed the presence of @entity8 with @entity15740 bilaterally and a persistent @entity4264 (PLSVC). Both pregnant @entity1 underwent cord blood samplings because of the abnormal imaging results. Karyotype analysis revealed normal results in the two fetuses. Chromosome microarray analysis (CMA) was then performed to provide genetic analysis of the cord blood and parental blood samples. Ultimately, the pregnancies were both terminated. RESULTS: CMA detected a 1.56-Mb duplication at 17q12 in Fetus 1 and a 1.93-Mb deletion of 17q12 in Fetus 2. Both the duplicated and deleted regions included the @entity5456 and @entity21956 genes. Neither the duplication nor deletion was inherited from the parents. CONCLUSION: This study is the first to report the prenatal diagnosis of a 17q12 duplication syndrome. Our results further confirmed that genes in this region, including @entity5456 and @entity21956 , are essential for normal brain and kidney development, and also indicated some genes that may be associated with the @entity65 . Combined with imaging examination, the use of CMA will improve the diagnosis of submicroscopic chromosomal aberrations in fetuses with @entity154 .

title: Prenatal diagnosis of 17q12 duplication and deletion syndrome in two fetuses with XXXX .

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital anomalies']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['hyperechogenic and enlarged kidneys']

entities_list: @entity4264 :: ('MESH:D013479', 'Disease') :: ['left superior vena cava']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['ventriculomegaly']

entities_list: @entity15740 :: ('MESH:D021782', 'Disease') :: ['multicystic renal dysplasia']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic abnormalities']

entities_list: @entity4242 :: ('MESH:D008831', 'Disease') :: ['microcephaly']

entities_list: @entity6789 :: ('MESH:D061085', 'Disease') :: ['corpus callosum']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular abnormality']

answer: @entity154 :: (MESH:D000013,Disease) :: ['congenital anomalies']


abstract: In recent years, the nucleus accumbens (NAS) has gained prominence because of an interest in the role of @entity2922 in the intracranial self-stimulation (ICSS). The NAS receives strong projections from @entity935 of the ventral tegmemtal area (VTA) which form the meso-limbic @entity935 pathway (A10). The major purpose of the present study was to investigate the ICSS of NAS with special emphasis on its associated behavior. The results obtained were as follows: 1. ICSS was observed in @entity35 with electrodes in the NAS. The rate of its ICSS was 230 +/- 142/15 min. 2. @entity12463 ( @entity12463 ) in the VTA were observed with stimulation of NAS including stimulation of sites associated with ICSS. The latency of @entity12463 was 25.5 +/- 4.3 msec. (range 10.0-42.0 msec). 3. ICSS of NAS was chiefly associated with "approach-escape" behavior and/or sniffing for which its electrodes were observed to distribute on widespread scatter through NAS. The electrodes of digging and/or licking groups were localized historogically in the vicinity of the commissura anterior.

title: [Intracranial self-stimulation of the nucleus accumbens of the XXXX and its associated behavior (author's transl)].

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity12463 :: ('MESH:D031261', 'Disease') :: ['AS', 'Antidromic spikes']

entities_list: @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: With regard to the toxic effects of Ricinus lectin, @entity689 -treated @entity157 cells have been found to be the most sensitive, and untreated @entity157 cells the least. Cells treated with @entity689 and @entity3649 oxidase exhibited an intermediate sensitivity. At 37 degrees C, the number of Ricinus lectin molecules bound to untreated, @entity689 -treated and @entity689 and @entity3649 oxidase-treated cells required to being about 30% @entity137 within 2 h was 15 . 10(5), 7.5 . 10(5) and 11.5 . 10(5) molecules/cell, respectively. This difference was rather small and suggests that the additional binding sites exposed following enzyme treatment were as efficient in mediating lectin @entity137 as those present before enzyme treatment. Positive cooperativity was observed during Ricinus lectin binding to enzyme-treated cells at 37 degrees C and the apparent association constant increased with the increase of binding site occupancy. The binding sites on enzyme-treated cells appeared to be homogeneous since under different physical conditions (4 degrees C) the shape of the Scatchard plot could be altered in such a way as to produce a single line of slope. In contrast to enzyme-treated cells, untreated cells did not exhibit a positive cooperative process either at 37 degrees C or at 4 degrees C. We found that the @entity137 of Ricinus lectin paralleled the irreversible specific binding of lectin, suggesting that only this was able to mediate the toxic effect. Our results are discussed in terms of the possible entry into the cells of Ricinus lectin and this occurs more rapidly in enzyme-treated than in untreated cells. This difference agrees with the sequence of events proposed: (i) Binding of Ricinus lectin; (ii) Clustering of lectin binding sites; and (iii) Endocytosis.

title: Toxic effect of Ricinus lectin on XXXX cells in relation to enzyme modification of the cell surface.

entities_list: @entity689 :: ('4758', 'Gene') :: ['neuraminidase']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatoma']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity3649 :: ('MESH:D005690', 'Chemical') :: ['galactose']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatoma']


abstract: BACKGROUND: The role of @entity1229 in anterior @entity583 ( @entity583 ) complicated by @entity1002 in @entity1 treated with primary percutaneous coronary intervention (PCI) and dual antiplatelet therapy is unclear. @entity1229 may prevent cardioembolic events but significantly increases @entity548 in the setting of dual antiplatelet therapy. HYPOTHESIS: The incidence of LV @entity715 in anterior @entity583 @entity1 treated with PCI is low, and clinical predictors might be valuable in determining @entity1 at risk. METHODS: We performed a retrospective, single-center study of 687 consecutive @entity1 with anterior @entity583 treated with PCI from 2006 to 2013. Baseline variables were evaluated in 310 @entity1 at high risk for LV @entity715 based on echocardiographic criteria. @entity1 with definite, probable, and no LV @entity715 were compared by ANOVA,   (2) , or t test where appropriate. Logistic regression analysis was performed. RESULTS: The incidence of LV @entity715 was 15% (n   =   47 probable/definite @entity715 ). @entity1167 was the only independent characteristic associated with increased risk of LV @entity715 (odds ratio [OR]: 4.06, 95% confidence interval [CI]: 1.3-12.7). Trends were observed for a lower risk in @entity1455 (OR: 0.33, 95% CI: 0.10-1.05) and @entity117 use at baseline (OR: 0.43, 95% CI: 0.17-1.1). Treatment variables associated with LV @entity715 included unfractionated heparin use post-PCI (OR: 2.43, 95% CI: 1.16-5.1) and use of balloon angioplasty without stent. CONCLUSIONS: In contemporary practice with primary PCI, definite LV @entity715 following anterior @entity583 with @entity1002 is challenging to predict. Further investigation is needed to determine if there is a subset of @entity1 that should be treated with prophylactic @entity1229 .

title: Incidence and Predictors of XXXX After Primary Percutaneous Coronary Intervention for Anterior ST-Segment Elevation @entity583 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['Warfarin', 'warfarin']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['Cardiac arrest']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-segment elevation myocardial infarction']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular (LV) dysfunction', 'LV dysfunction']

answer: @entity1002 :: (MESH:D018487,Disease) :: ['Left Ventricular Thrombus']


abstract: BACKGROUND: The role of @entity1229 in anterior @entity583 ( @entity583 ) complicated by @entity1002 in @entity1 treated with primary percutaneous coronary intervention (PCI) and dual antiplatelet therapy is unclear. @entity1229 may prevent cardioembolic events but significantly increases @entity548 in the setting of dual antiplatelet therapy. HYPOTHESIS: The incidence of LV @entity715 in anterior @entity583 @entity1 treated with PCI is low, and clinical predictors might be valuable in determining @entity1 at risk. METHODS: We performed a retrospective, single-center study of 687 consecutive @entity1 with anterior @entity583 treated with PCI from 2006 to 2013. Baseline variables were evaluated in 310 @entity1 at high risk for LV @entity715 based on echocardiographic criteria. @entity1 with definite, probable, and no LV @entity715 were compared by ANOVA,   (2) , or t test where appropriate. Logistic regression analysis was performed. RESULTS: The incidence of LV @entity715 was 15% (n   =   47 probable/definite @entity715 ). @entity1167 was the only independent characteristic associated with increased risk of LV @entity715 (odds ratio [OR]: 4.06, 95% confidence interval [CI]: 1.3-12.7). Trends were observed for a lower risk in @entity1455 (OR: 0.33, 95% CI: 0.10-1.05) and @entity117 use at baseline (OR: 0.43, 95% CI: 0.17-1.1). Treatment variables associated with LV @entity715 included unfractionated heparin use post-PCI (OR: 2.43, 95% CI: 1.16-5.1) and use of balloon angioplasty without stent. CONCLUSIONS: In contemporary practice with primary PCI, definite LV @entity715 following anterior @entity583 with @entity1002 is challenging to predict. Further investigation is needed to determine if there is a subset of @entity1 that should be treated with prophylactic @entity1229 .

title: Incidence and Predictors of @entity1002 After Primary Percutaneous Coronary Intervention for Anterior ST-Segment Elevation XXXX .

answer: @entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']


abstract: OBJECTIVE: The facial esthetics after orthodontic treatment and orthognathic surgery may be affected by the @entity1 's natural head position. The purpose of this study was to evaluate the natural head position for the three skeletal classes of @entity3232 . MATERIALS AND METHODS: Our sample consisted of 102 lateral cephalometric radiographs of @entity1 aged 15 to 18 years; class I (n=32), class II (n=40) and class III (n=30). Nine landmarks of the craniofacial skeleton and three landmarks of the cervical vertebrae were determined. Variables consisted of two angles for cervical posture (OPT/Hor and @entity19312 /Hor), three angles for craniofacial posture (SN/Ver, PNS-ANS/Ver, and ML/Ver ) and five for craniofacial angulation (SN/OPT, SN/ @entity19312 , PNS-ANS/OPT, PNS-ANS/ @entity19312 , ML/ @entity19312 ). The data were analyzed statistically using ANOVA and post hoc tests. RESULTS: PNS-ANS/Ver and SN/Ver differed significantly (p<0.05) among the three groups. There were no significant differences between class I and class II @entity3232 for the indicator angles of cranial posture except for ML/Ver. The SN/ @entity19312 was significantly different for class I compared to class III @entity1 . A head posture camouflaging the underlying skeletal class III was observed in our population. CONCLUSION: A more forward head posture was observed in skeletal class III @entity1 compared to skeletal class I and II and that class III @entity1 tended to incline their head more ventral compared to class I @entity1 . These findings may have implications for the amount of @entity89 during surgery particularly in @entity1 with a @entity3233 .

title: Comparison of natural head position in different anteroposterior XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity3233 :: ('MESH:D008313', 'Disease') :: ['class III malocclusion']

entities_list: @entity3232 :: ('MESH:D008310', 'Disease') :: ['malocclusions', 'malocclusion']

entities_list: @entity89 :: ('MESH:D007571', 'Disease') :: ['jaw movements']

answer: @entity3232 :: (MESH:D008310,Disease) :: ['malocclusions']