abstract: OBJECTIVE: To evaluate whether the use of intraoperative @entity6948 ( @entity9170 ) during @entity2 surgery may reduce the incidence of @entity810 ( @entity810 ). DESIGN: A retrospective study. SETTING: An academic hospital. @entity1 : Data were collected from 1,207 adult @entity1 who underwent resection for non-small-cell @entity2 between January 2004 and December 2012. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: All @entity1 had a general balanced anesthetic technique, and @entity6948 use was at the discretion of the anesthesiologist. Data analysis was done utilizing the Wilcoxon rank sum tests and Chi-square tests to compare continuous variables and categoric variables between the 2 groups, respectively. Multivariate logistic analysis with backward selection was fitted to find out factors for @entity810 incidence. Overall, 8.1% of the @entity1 developed @entity810 during their hospital stay. There were no statistically significant differences in demographic, perioperative variables, and the incidence of @entity810 between @entity1 who did and did not receive @entity9170 . A logistic regression model was fitted to determine factors independently associated with @entity810 . Factors that were independently associated with @entity810 included body mass index, American Society of Anesthesiologists 3-4, @entity101 , smoking status, and thoracotomy procedure. DISCUSSION: The authors hypothesized that @entity9170 use would be associated with a decreased incidence of @entity810 in thoracic surgery; however, they were unable to prove this hypothesis. Their results did demonstrate that there are 5 factors independently associated with @entity810 .

title: The Use of Intraoperative XXXX is Not Associated With a Reduction in Acute Kidney Injury After Lung Cancer Surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury']

entities_list: @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine']

answer: @entity6948 :: (MESH:D020927,Chemical) :: ['Dexmedetomidine']


abstract: OBJECTIVE AND IMPORTANCE: Traumatic @entity438 present diagnostic and therapeutic challenges. Owing to their fragile nature, endovascular intervention has become the first-line treatment; however, direct surgery has an advantage in certain cases. CLINICAL PRESENTATION: A 34-year-old @entity1 in @entity772 was admitted after a motor vehicle accident. Brain computed tomographic scans revealed deep bifrontal, left intraventricular, and @entity510 . Three-dimensional computed tomographic angiography and digital subtraction angiography revealed an @entity439 arising from the left pericallosal artery. INTERVENTION: A massive @entity1779 prompted us to perform emergency surgical intervention. We immediately removed the @entity1410 and extirpated the @entity439 . After @entity1410 evacuation via the interhemispheric approach, a pulsating red sphere projecting from the pericallosal artery, with no obvious solid wall or neck, was encountered. While retracting the frontal lobe, it suddenly ruptured. Under temporary trapping of the parent artery, the point of @entity548 was identified. No @entity439 wall or fibrous tissue was present, whereas a 1.5-mm laceration was observed at the pericallosal artery close to its branching point. The laceration was sutured with 10-0 nylon. Postoperative digital subtraction angiography confirmed patency of the pericallosal artery. CONCLUSIONS: Although recent technologic advances of intravascular surgery have enabled successful treatment of @entity2849 , open surgical intervention still has some advantages of providing definitive hemostasis, allowing for parent artery reconstruction, and facilitating mass reduction. The case in the current study was quite unusual in that angiographic @entity439 had disrupted easily, leaving @entity4551 . This finding implies the probability of unavoidable parent artery occlusion when endovascular treatment is applied.

title: Surgical Repair of Lacerated Anterior Cerebral Artery Presented With Massive XXXX .

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhages']

entities_list: @entity4551 :: ('MESH:D022125', 'Disease') :: ['arterial laceration']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hematoma']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['traumatic pseudoaneurysms']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms']

answer: @entity1779 :: (MESH:D002543,Disease) :: ['Intracerebral Hemorrhage']


abstract: OBJECTIVE: To investigate the clinical features and outcome of outpatient-based physiotherapy (manual stretch) of @entity9282 ( @entity9282 ) with @entity135 limitation (>= 10  ) according to whether the finding on ultrasonography (US) is normal or abnormal. DESIGN: Case-control study. SETTING: Institutional practice. @entity1 : A total of 149 @entity1 with @entity9282 who met eligibility criteria were included: age at presentation  <=6 months, limitation of passive @entity717 (  ROT) or lateral flexion (  LAT) >= 10  , and completion of our outpatient-based physiotherapy program. INTERVENTIONS: @entity1 were allocated to the US-normal or US-abnormal group. @entity1 underwent physiotherapy and were followed-up monthly until   ROT and   LAT were  <=5   or did not respond to treatment. MAIN OUTCOME MEASUREMENTS: Baseline characteristics, initial   ROT and   LAT, age at presentation, treatment durations, and success rates of physiotherapy were compared between 2 groups. Treatment duration was adjusted for initial   ROT,   LAT, and age at presentation using analysis of covariance. RESULTS: Mean initial   ROT and   LAT in US-abnormal (28.5  ; 17.0  ) were greater than in US-normal (7.9  , P < .001; 12.3  , P = .001, respectively). Mean age at presentation was older in US-normal (3.8 months) than in US-abnormal (1.8 months, P < .001). Treatment duration was shorter in the US-normal (5.1 weeks) than US-abnormal (14.9 weeks, P < .001). Adjusted treatment duration was also shorter in US-normal (9.7 weeks) than US-abnormal (13.8 weeks, P < .05). The success rates of physiotherapy were 95% in US-abnormal and 100% in US-normal. Two of 6 treatment failures in the US-abnormal group underwent surgery. CONCLUSIONS: In @entity9282 with @entity135 limitation (>= 10  ), @entity1 in the US-normal group demonstrated lesser @entity135 limitation and older age at presentation than US-abnormal. It seems that US-normal showed shorter treatment duration irrespective of severity of neck motion limitation and age at presentation. Additionally, manual stretching applied before 6 months of age appears to show generally good outcome regardless of US findings.

title: A Clinical Comparative Study of Ultrasound-Normal Versus Ultrasound-Abnormal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['passive neck motion']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['neck rotation']

entities_list: @entity9282 :: ('MESH:C535425', 'Disease') :: ['congenital muscular torticollis', 'CMT']

answer: @entity9282 :: (MESH:C535425,Disease) :: ['Congenital Muscular Torticollis']


abstract: AIM: To report on a possible relationship between the use of dental floss or superfloss and the development of @entity737 . MATERIALS AND METHODS: Ten @entity1 with progressive @entity737 with an intensive oral hygiene protocol, which consisted of extensive professional supra- and submucosal cleaning, and not responding to this therapy were scheduled for examination. Plaque and @entity548 indices and probing depth measurements were assessed, and radiographic examination was performed every two years. RESULTS: In all ten cases, remnants of dental floss were found around the neck and coronal part of a dental implant. After careful removal of these floss remnants and implant cleansing, a significant improvement in the peri-implant conditions in nine of ten cases was noted. In one case, peri-implant probing depth decreased substantially. However, @entity548 on probing was still present. In vitro testing yielded that the application of various types of dental floss on the exposed rough implant surfaces may easily lead to tearing of floss fibers. This may result in the deposition of floss remnants on rough implant surfaces, which, in turn, may lead to the development of plaque-related peri-implant inflammation and, subsequently, @entity604 . CONCLUSION: In case of exposed rough surfaces of the dental implant, the peri-implant conditions may be jeopardized by the application of dental floss, and hence, the utilization of interproximal brushes or toothpicks may be preferred for daily home care practices.

title: Dental floss as a possible risk for the development of XXXX : an observational study of 10 cases.

entities_list: @entity737 :: ('MESH:D057873', 'Disease') :: ['peri-implantitis']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

answer: @entity737 :: (MESH:D057873,Disease) :: ['peri-implant disease']


abstract: Recent studies support the use of @entity1749 -based therapies in light chain @entity2783 ( @entity2783 ). We performed a retrospective analysis of the safety, efficacy and long-term survival (median follow-up 3 years) after @entity1749 -based treatment in 28 consecutive @entity1 with de novo @entity2783 deemed ineligible at initial presentation. The first 14 @entity1 received @entity1749 and @entity619 (VD), and the second 14 @entity1 received @entity786 , @entity1749 and @entity619 (CVD; CyBorD). Both regimens were well tolerated with no treatment-related mortality. The overall hematological response (HR) rate was 93% in both the groups. Median time to response was shorter in the CVD group (39 days vs 96 days in the VD group; P=0.002). Hematological and organ responses induced with @entity1749 -based therapy enabled 8 (33%) of initially transplant ineligible @entity1 to undergo autologous hematopoietic stem cell transplantation (AHCT), including 4 @entity1 with cardiac stage III or IV. Seven of the eight @entity1 (88%) who underwent subsequent AHCT achieved sustained HR at a median of 33 months posttransplant. These data suggest that @entity1749 -based induction followed by AHCT is a viable therapeutic strategy for transplant-ineligible @entity2783 . Larger, multicenter prospective trials are necessary to confirm our findings.

title: XXXX -based induction for transplant ineligible @entity2783 and feasibility of later transplantation.

entities_list: @entity2783 :: ('MESH:D000686', 'Disease') :: ['AL', 'amyloidosis']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity1749 :: ('MESH:C400082', 'Chemical') :: ['bortezomib']

answer: @entity1749 :: (MESH:C400082,Chemical) :: ['Bortezomib']


abstract: Recent studies support the use of @entity1749 -based therapies in light chain @entity2783 ( @entity2783 ). We performed a retrospective analysis of the safety, efficacy and long-term survival (median follow-up 3 years) after @entity1749 -based treatment in 28 consecutive @entity1 with de novo @entity2783 deemed ineligible at initial presentation. The first 14 @entity1 received @entity1749 and @entity619 (VD), and the second 14 @entity1 received @entity786 , @entity1749 and @entity619 (CVD; CyBorD). Both regimens were well tolerated with no treatment-related mortality. The overall hematological response (HR) rate was 93% in both the groups. Median time to response was shorter in the CVD group (39 days vs 96 days in the VD group; P=0.002). Hematological and organ responses induced with @entity1749 -based therapy enabled 8 (33%) of initially transplant ineligible @entity1 to undergo autologous hematopoietic stem cell transplantation (AHCT), including 4 @entity1 with cardiac stage III or IV. Seven of the eight @entity1 (88%) who underwent subsequent AHCT achieved sustained HR at a median of 33 months posttransplant. These data suggest that @entity1749 -based induction followed by AHCT is a viable therapeutic strategy for transplant-ineligible @entity2783 . Larger, multicenter prospective trials are necessary to confirm our findings.

title: @entity1749 -based induction for transplant ineligible XXXX and feasibility of later transplantation.

answer: @entity2783 :: (MESH:D000686,Disease) :: ['AL amyloidosis']


abstract: OBJECTIVE: To assess the diagnostic accuracy of recommendations for self-monitoring blood pressure (BP) for diagnosing @entity101 in primary care. METHODS: Two hundred and forty-seven consecutive @entity1 with raised (>= 130mmHg systolic) BP measured by their general practitioner from four primary care practices in the United Kingdom underwent 28 days of self-monitoring followed by 24-h ambulatory BP monitoring (ABPM). Diagnostic accuracy of the first 7 days of self-monitored BP (minimum 4 days, discarding readings on day 1) in detecting @entity101 with ambulatory blood pressure was taken as reference. RESULTS: Two hundred and three @entity1 were included, 109 (53.7%) of whom were diagnosed with @entity101 using daytime ambulatory BP. The average of days 2-7 self-monitored BP correctly classified 150 of 203 @entity1 [sensitivity 93.6%, 95% confidence interval (CI) 87.2-97.4%; specificity 51.1%, 95% CI 40.5-61.5%). However, the average of days 2-5 self-monitoring correctly classified 152 of 203 @entity1 due to better specificity (53.2%, 95% CI 42.6-63.6%). In sensitivity analysis, diagnostic accuracy was not improved by inclusion of readings beyond day 5, and inclusion of readings taken on day 1 had no impact on diagnostic accuracy. Self-monitoring in the clinic was more accurate than readings taken by the general practitioner, but not self-monitoring outside of the clinic. CONCLUSION: @entity101 can be ruled out in the majority of @entity1 with elevated clinic BP using the average of the first 5 consecutive days of self-monitored BP, supporting lower limits for self-monitoring readings in current guidelines. Performing readings beyond day 5 and including readings taken on the first day had no clinical impact on diagnostic accuracy.

title: Accuracy of self-monitored blood pressure for diagnosing XXXX in primary care.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: BACKGROUND/AIMS: This multicenter and single arm phase II clinical trial was performed to examine the safety and efficacy of modified FOLFOX6 (mFOLFOX6) as adjuvant treatment after resection of liver metastases from @entity14 . METHODOLOGY: @entity1 who had undergone R0-1 resection of liver metastases were assigned to 12 cycles of mFOLFOX6. The primary end point was disease-free survival (DFS). RESULTS: We enrolled 49 cases and analyzed adverse events in 48 cases, since in one @entity1 @entity5 recurred before starting treatment. As to the relative dose intensity, @entity1487 was 78.8%, and @entity901 was 75.9%. Adverse events of Grade 3 and above includ- ed 18 cases of @entity1398 (37.5%), 4 cases of @entity16 (8.3%), 4 cases of @entity882 (8.3%) and 4 cases of @entity566 (8.3%), and there were no cases of @entity3329 caused by adverse events. The most difference of adverse event compared with MOSAIC trial (Multicenter International Study of @entity901 / @entity1487 -LV in the Adjuvant Treatment of @entity694 ) was @entity882 . The 2-year DFS was 59.2% (95% CI: 36.7-78.4) in the 49 enrolled cases. CONCLUSION: mFOLFOX6 after hepatectomy was tolerable. And mFOLFOX6 also seemed to improve DFS. mFOLFOX is one of the options for such @entity1 and appears promising as an adjuvant treatment.

title: Feasibility Assessment of Modified FOLFOX-6 as adjuvant treatment after resection of liver metastases from XXXX : analyses of a multicenter phase II clinical trial (Miyagi-HBPCOG Trial-001).

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patient', 'patients']

entities_list: @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin', 'Oxaliplatin']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['sensory neuropathy']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['Colon Cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: BACKGROUND: Little is known of the epidemiology of @entity12967 in sub-Saharan Africa. We performed a population-based survey in Zambia using methods previously tested in multiple other countries. METHODS: This cross-sectional survey was conducted by visiting households unannounced, using cluster-randomized sampling, in the mostly urban Lusaka Province and mostly rural Southern Province. Within clusters, households were selected randomly, as was one adult member (18-65 years old) of each selected household. A structured questionnaire, translated into the local languages, was administered face-to-face by trained interviewers. Demographic enquiry was followed by diagnostic questions based on @entity1605 . A random sub-sample of @entity1 were invited for subsequent physician-interview to validate the diagnostic part of the questionnaire. RESULTS: Of 1,134 eligible household members contacted, 1,085 (450 male, 887 urban) consented to interview (refusal rate 4.3%). Others who had been selected but remained unavailable on three visits were not counted as refusals since their reasons were unknown, but gave rise to gender biases, being mostly male in urban areas and mostly female in rural areas. Statistical correction was applied. Adjusted for gender and habitation (urban/rural), the 1-year prevalence of any @entity10 was 61.6%, of @entity2704 22.9%, of @entity2701 ( @entity2701 ) 22.8%, of @entity10 on >= 15 days/month 11.5% and of probable medication-overuse @entity10 (pMOH) 7.1%. The adjusted point-prevalence of any @entity10 ( @entity10 yesterday) was 19.1%. There was a small proportion (5.3%) of unclassified @entity10 , some of which may have been secondary. The overwhelmingly strong association was between urban dwelling and pMOH (OR: 8.6; P=0.0001), with an urban prevalence of 14.5% (gender-adjusted). Validation of the questionnaire was limited by @entity1 ' reluctance to present for physician review, substantial delays in doing so and major self-selection bias among those who did. These were unavoidable problems in resource-limited Zambia. CONCLUSIONS: @entity12967 , common in high-income countries, are at least as prevalent in Zambia, a sub-Saharan African country. The selectively urban problem of pMOH seems likely to reflect ready availability of non-prescription analgesics, without easy access to professional health care for @entity10 or any focused public-health education regarding correct usage of analgesics or the dangers of their overuse.

title: The epidemiology of XXXX in Zambia: a population-based door-to-door survey.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['ICHD-II criteria']

entities_list: @entity12967 :: ('MESH:D051270', 'Disease') :: ['Primary headache disorders', 'primary headache disorders']

entities_list: @entity2701 :: ('MESH:D018781', 'Disease') :: ['tension-type headache', 'TTH']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity12967 :: (MESH:D051270,Disease) :: ['primary headache disorders']


abstract: PURPOSE: To investigate changes in cytokine levels in tears of type 2 @entity6 with or without @entity989 . METHODS: Tears were collected from 15 type 2 @entity6 without @entity989 (DNR), 15 @entity1 with @entity989 (DR), and 15 age and gender matched non- @entity6 controls. Tear concentrations of 27 cytokines were measured by multiplex bead immunoassay. Cytokine differences between groups, ratios of type-1 T helper ( @entity1198 )/type-2 T helper (Th2) cytokines and anti-angiogenic/pro-angiogenic cytokines were analyzed statistically. RESULTS: The most abundant cytokine detected in tears was @entity371 ( @entity371 ). In comparison with controls, @entity371 and @entity2842 ( @entity2842 ) levels were significantly elevated in DR (p=0.016 and 0.036, respectively) and DNR groups (p=0.021 and 0.026, respectively). @entity1193 ( @entity1193 ) levels were significantly increased in DNR (p=0.016). @entity1198 /Th2 cytokines @entity379 ( @entity379 )/ @entity225 and @entity1199 / @entity225 ratios were significantly increased in DR compared to controls (p=0.037 and 0.031, respectively). Anti-angiogenic/angiogenic cytokines @entity379 / @entity2842 and @entity3646 / @entity2842 ratios in DR and DNR were significantly decreased compared to controls (p<0.05). @entity3646 / @entity687 and IL-12p70/ @entity687 ratios were also significantly decreased in DR compared to controls (p=0.02 and 0.045, respectively). No significant correlation was demonstrated between tear cytokine concentrations and glycosylated hemoglobin (HbA1c) or fasting plasma @entity413 (FPG). CONCLUSIONS: @entity6 tears exhibited elevated levels of @entity371 and @entity2842 . The @entity1198 /Th2 cytokine balance may shift to a predominantly @entity1198 state in DR @entity1 . Pro-angiogenic cytokines are more highly represented than anti-angiogenic cytokines in the tears of @entity6 @entity1 .

title: Changes to tear cytokines of type 2 XXXX @entity1 with or without @entity989 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetics', 'diabetic']

entities_list: @entity1193 :: ('3557', 'Gene') :: ['Interleukin-1 (IL-1) receptor antagonist', 'IL-1ra']

entities_list: @entity2842 :: ('6347', 'Gene') :: ['MCP-1', 'monocyte chemoattracant protein-1']

entities_list: @entity379 :: ('3458', 'Gene') :: ['IFN-y', 'interferon-gamma']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity371 :: ('3627', 'Gene') :: ['IP-10', 'interferon-induced protein-10']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic']


abstract: PURPOSE: To investigate changes in cytokine levels in tears of type 2 @entity6 with or without @entity989 . METHODS: Tears were collected from 15 type 2 @entity6 without @entity989 (DNR), 15 @entity1 with @entity989 (DR), and 15 age and gender matched non- @entity6 controls. Tear concentrations of 27 cytokines were measured by multiplex bead immunoassay. Cytokine differences between groups, ratios of type-1 T helper ( @entity1198 )/type-2 T helper (Th2) cytokines and anti-angiogenic/pro-angiogenic cytokines were analyzed statistically. RESULTS: The most abundant cytokine detected in tears was @entity371 ( @entity371 ). In comparison with controls, @entity371 and @entity2842 ( @entity2842 ) levels were significantly elevated in DR (p=0.016 and 0.036, respectively) and DNR groups (p=0.021 and 0.026, respectively). @entity1193 ( @entity1193 ) levels were significantly increased in DNR (p=0.016). @entity1198 /Th2 cytokines @entity379 ( @entity379 )/ @entity225 and @entity1199 / @entity225 ratios were significantly increased in DR compared to controls (p=0.037 and 0.031, respectively). Anti-angiogenic/angiogenic cytokines @entity379 / @entity2842 and @entity3646 / @entity2842 ratios in DR and DNR were significantly decreased compared to controls (p<0.05). @entity3646 / @entity687 and IL-12p70/ @entity687 ratios were also significantly decreased in DR compared to controls (p=0.02 and 0.045, respectively). No significant correlation was demonstrated between tear cytokine concentrations and glycosylated hemoglobin (HbA1c) or fasting plasma @entity413 (FPG). CONCLUSIONS: @entity6 tears exhibited elevated levels of @entity371 and @entity2842 . The @entity1198 /Th2 cytokine balance may shift to a predominantly @entity1198 state in DR @entity1 . Pro-angiogenic cytokines are more highly represented than anti-angiogenic cytokines in the tears of @entity6 @entity1 .

title: Changes to tear cytokines of type 2 @entity6 @entity1 with or without XXXX .

answer: @entity989 :: (MESH:D012164,Disease) :: ['retinopathy']


abstract: PURPOSE: To investigate changes in cytokine levels in tears of type 2 @entity6 with or without @entity989 . METHODS: Tears were collected from 15 type 2 @entity6 without @entity989 (DNR), 15 @entity1 with @entity989 (DR), and 15 age and gender matched non- @entity6 controls. Tear concentrations of 27 cytokines were measured by multiplex bead immunoassay. Cytokine differences between groups, ratios of type-1 T helper ( @entity1198 )/type-2 T helper (Th2) cytokines and anti-angiogenic/pro-angiogenic cytokines were analyzed statistically. RESULTS: The most abundant cytokine detected in tears was @entity371 ( @entity371 ). In comparison with controls, @entity371 and @entity2842 ( @entity2842 ) levels were significantly elevated in DR (p=0.016 and 0.036, respectively) and DNR groups (p=0.021 and 0.026, respectively). @entity1193 ( @entity1193 ) levels were significantly increased in DNR (p=0.016). @entity1198 /Th2 cytokines @entity379 ( @entity379 )/ @entity225 and @entity1199 / @entity225 ratios were significantly increased in DR compared to controls (p=0.037 and 0.031, respectively). Anti-angiogenic/angiogenic cytokines @entity379 / @entity2842 and @entity3646 / @entity2842 ratios in DR and DNR were significantly decreased compared to controls (p<0.05). @entity3646 / @entity687 and IL-12p70/ @entity687 ratios were also significantly decreased in DR compared to controls (p=0.02 and 0.045, respectively). No significant correlation was demonstrated between tear cytokine concentrations and glycosylated hemoglobin (HbA1c) or fasting plasma @entity413 (FPG). CONCLUSIONS: @entity6 tears exhibited elevated levels of @entity371 and @entity2842 . The @entity1198 /Th2 cytokine balance may shift to a predominantly @entity1198 state in DR @entity1 . Pro-angiogenic cytokines are more highly represented than anti-angiogenic cytokines in the tears of @entity6 @entity1 .

title: Changes to tear cytokines of type 2 @entity6 XXXX with or without @entity989 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: STUDY OBJECTIVE: The adaptive value of the endogenous circadian clock arises from its ability to synchronize (i.e., entrain) to external light-dark (LD) cycles at an appropriate phase. Studies have suggested that advanced circadian phase alignment might result from shortening of the period length of the clock. Here we explore mechanisms that contribute to an early activity phase in @entity36992 ( @entity36992 ) @entity19 . METHODS: We investigated circadian rhythms of wheel-running activity in C57BL/6J (B6), @entity36992 and 2 strains of B6. @entity36992 congenic @entity19 , which carry @entity36992 segments introgressed in a B6 genome. RESULTS: When entrained, all @entity36992 @entity19 initiate daily activity several hours earlier than normal @entity19 . This difference could not be explained by alterations in the endogenous period, as activity onset did not correlate with period length. However, the photic phase-shifting responses in these @entity19 were phase-lagged by 3 hours relative to their activity. Attenuated light masking responses were also found in @entity36992 @entity19 , which allow for activity normally inhibited by light. A previously identified quantitative trait locus (QTL), @entity53837 , which contributes to the early activity trait, was confirmed and refined here using two B6. @entity36992 congenic strains. Surprisingly, these B6. @entity36992 @entity19 exhibited longer rather than shorter endogenous periods, further demonstrating that the advanced phase in these @entity19 is not due to alterations in period. CONCLUSIONS: @entity36992 @entity19 have an advanced activity phase similar to @entity1 @entity1442 . This advanced phase is not due to its shorter period length or smaller light-induced phase shifts, but appears to be related to both light masking and altered coupling of the circadian pacemaker with various outputs. Lastly, a QTL influencing this trait was confirmed and narrowed using congenic @entity19 as a first step toward gene identification.

title: Behavioral and genetic dissection of a @entity19 model for XXXX .

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced sleep phase syndrome']

answer: @entity1442 :: (MESH:D020178,Disease) :: ['advanced sleep phase syndrome']


abstract: STUDY OBJECTIVE: The adaptive value of the endogenous circadian clock arises from its ability to synchronize (i.e., entrain) to external light-dark (LD) cycles at an appropriate phase. Studies have suggested that advanced circadian phase alignment might result from shortening of the period length of the clock. Here we explore mechanisms that contribute to an early activity phase in @entity36992 ( @entity36992 ) @entity19 . METHODS: We investigated circadian rhythms of wheel-running activity in C57BL/6J (B6), @entity36992 and 2 strains of B6. @entity36992 congenic @entity19 , which carry @entity36992 segments introgressed in a B6 genome. RESULTS: When entrained, all @entity36992 @entity19 initiate daily activity several hours earlier than normal @entity19 . This difference could not be explained by alterations in the endogenous period, as activity onset did not correlate with period length. However, the photic phase-shifting responses in these @entity19 were phase-lagged by 3 hours relative to their activity. Attenuated light masking responses were also found in @entity36992 @entity19 , which allow for activity normally inhibited by light. A previously identified quantitative trait locus (QTL), @entity53837 , which contributes to the early activity trait, was confirmed and refined here using two B6. @entity36992 congenic strains. Surprisingly, these B6. @entity36992 @entity19 exhibited longer rather than shorter endogenous periods, further demonstrating that the advanced phase in these @entity19 is not due to alterations in period. CONCLUSIONS: @entity36992 @entity19 have an advanced activity phase similar to @entity1 @entity1442 . This advanced phase is not due to its shorter period length or smaller light-induced phase shifts, but appears to be related to both light masking and altered coupling of the circadian pacemaker with various outputs. Lastly, a QTL influencing this trait was confirmed and narrowed using congenic @entity19 as a first step toward gene identification.

title: Behavioral and genetic dissection of a XXXX model for @entity1442 .

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: OBJECTIVE: The physiological persistence of fetal cells in the circulation and tissue of a previously pregnant @entity1 is called fetal cell microchimerism (FCM). It has been hypothesized to play a role in @entity792 ; however, only limited data are available regarding its role in @entity1669 ( @entity1669 ). DESIGN: Circulating FCM was analyzed in a large series of previously pregnant @entity1 with @entity2743 ( @entity2743 ), @entity2621 ( @entity2621 ), or no disease (healthy controls (HCs)). To exclude the possible bias related to placental factors, the polymorphic pattern of human leukocyte antigen-G ( @entity6393 ) gene, which is known to be involved in the tolerance of fetal cells by the maternal immune system, was investigated. METHODS: FCM was evaluated by PCR in the peripheral blood, and the Y chromosome was identified by fluorescence in situ hybridization in some @entity2743 tissues. @entity6393 polymorphism typing was assessed by real-time PCR. RESULTS: FCM was significantly more frequent in HC (63.6%) than in @entity2743 (33.3%) or @entity2621 (27.8%) @entity1 (P=0.0004 and P=0.001 respectively). A quantitative analysis confirmed that circulating male DNA was more abundant in HC than it was in @entity2743 or @entity2621 . Microchimeric cells were documented in vessels and in thyroid follicles. In neither @entity2743 / @entity2621 @entity1 nor HC @entity1 was the @entity6393 typing different between FCM-positive and FCM-negative cases. CONCLUSION: The higher prevalence of FCM in HC as compared to @entity2743 and @entity2621 @entity1 suggests that it plays a possible protective role in @entity1669 . Placental factors have been excluded as determinants of the differences found. The vascular and tissue localization of microchimeric cells further highlights the ability of those cells to migrate to damaged tissues.

title: Fetal cell microchimerism: a protective role in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patients']

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ["Graves' disease", 'GD']

entities_list: @entity2621 :: ('MESH:D050031', 'Disease') :: ["Hashimoto's thyroiditis", 'HT']

entities_list: @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease', 'AITD', 'autoimmune thyroid disorders']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['systemic autoimmune disease']

answer: @entity1669 :: (MESH:D013967,Disease) :: ['autoimmune thyroid diseases']


abstract: BACKGROUND: The demand for scientific biodiversity data is increasing, but taxonomic expertise is often limited or not available. DNA sequencing is a potential remedy to overcome this taxonomic impediment. Mitochondrial DNA is most commonly used, e.g., for species identification ("DNA barcoding"). Here, we present the first study in arthropods based on a near-complete species sampling of a family-level taxon from the entire Australian region. We aimed to assess how reliably mtDNA data can capture species diversity when many sister species pairs are included. Then, we contrasted phylogenetic subsampling with the hitherto more commonly applied geographical subsampling, where sister species are not necessarily captured. METHODOLOGY/PRINCIPAL FINDINGS: We sequenced 800 bp @entity9859 for 1,439 individuals including 260 Australian species (78% species coverage). We used clustering with thresholds of 1 to 10% and general mixed Yule Coalescent (GMYC) analysis for the estimation of species @entity3794 . The performance metrics used were taxonomic accuracy and agreement between the morphological and molecular species @entity3794 estimation. Clustering (at the 3% level) and GMYC reliably estimated species diversity for single or multiple geographic regions, with an error for larger clades of lower than 10%, thus outperforming parataxonomy. However, the rates of error were higher for some individual genera, with values of up to 45% when very recent species formed nonmonophyletic clusters. Taxonomic accuracy was always lower, with error rates above 20% and a larger variation at the genus level (0 to 70%). S  rensen similarity indices calculated for morphospecies, 3% clusters and GMYC entities for different pairs of localities was consistent among methods and showed expected decrease over distance. CONCLUSION/SIGNIFICANCE: @entity9859 sequence data are a powerful tool for large-scale species @entity3794 estimation, with a great potential for use in ecology and b-diversity studies and for setting conservation priorities. However, error rates can be high in individual lineages.

title: Mitochondrial XXXX sequence data reliably uncover patterns of insect diversity but suffer from high lineage-idiosyncratic error rates.

answer: @entity9859 :: (4512,Gene) :: ['cox1']


abstract: OBJECTIVE: To analyze the causes of the @entity455 and @entity39 of free flaps used for reconstruction of defects following @entity135 resection and the managements of these issues. METHODS: A total of 850 cases with @entity135 who underwent free flap reconstruction from October 2010 to April 2014 were studied retrospectively. The risks for @entity455 and @entity39 were analyzed with one-factor analysis and multivariate analysis. RESULTS: The total success rate of 95.1% (808/850) for the free flap reconstruction was obtained. Twelve flaps due to poor blood supply indicated during operation were replaced by other free flaps. Among 73 flaps with @entity455 , 31 flaps were salvaged by surgical exploration and subcutaneous injection of low molecular heparin @entity460 . Obesity, smoking, preoperative radiotherapy and surgeon's experience, rather than age, @entity101 and @entity6 , were the risk factors of @entity39 . Two-vein @entity254 had a higher success rate than one-vein @entity254 . CONCLUSIONS: The @entity39 rate of free flaps can be reduced by the choice of suitable flaps, subtly preparation of flaps, carefully vascular @entity254 , and prompt perioperative managements. The two-vein @entity254 is recommended. @entity6 , @entity101 and elderly @entity1 are not the contraindications for free flap reconstruction.

title: [Analysis of the causes of flap XXXX after head and neck reconstruction].

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer', 'head and neck tumors']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular crisis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'skin flap necrosis']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity39 :: (MESH:D009336,Disease) :: ['necrosis']


abstract: INTRODUCTION: @entity5 chemotherapy in the United States has been delivered mostly in an office-based setting since the late 1980s. However, in the past 5 years, more @entity1 have been treated in hospitals as a result of reimbursement changes. Intraperitoneal (IP) chemotherapy for @entity43 has been similarly affected. This report examines changes in care of @entity1 treated with IP chemotherapy in an office- versus hospital-based setting. METHODS: Over 10 years, 140 @entity1 with @entity43 were identified as candidates for IP chemotherapy. Of these @entity1 , 92 were treated in an oncology-dedicated infusion center in the office of a physicians' group; 48 were treated in a local hospital. Location was determined based on insurance coverage and reimbursement. Data collected included demographics, number of treatment cycles completed, length of each treatment, and adverse events. RESULTS: The age and ethnicity of @entity1 treated in the office versus hospital were similar. All six doses of intravenous IP chemotherapy were completed by 73 (79%) of 92 @entity1 treated in the office versus 23 (48%) of 48 @entity1 treated in the hospital (P < .001). The time of each infusion was longer in the hospital-versus office-based setting (P < .001). There were more adverse events associated with treatment in the hospital. CONCLUSION: IP chemotherapy is associated with worse outcomes in the hospital- compared with office-based setting. The reason seems to involve a relative lack of resources directed specifically to chemotherapy administration. If current reimbursement trends continue, this could result in decreased survival for @entity1 with @entity43 .

title: Impact of shifting from office- to hospital-based treatment facilities on the administration of intraperitoneal chemotherapy for XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: OBJECTIVE: To explore the computed tomographic (CT) and pathological findings of small @entity1419 and improve its understanding. METHODS: A total of 20 @entity1 with bile duct non-dilatation peripheral small @entity1419 were retrospectively analyzed. All of them were examined by plain and enhanced CT and pathological studies. RESULTS: CT plain scan:there were 15 cases of low-density lesions with fibers and @entity39 tissue and surviving @entity5 tissue in peripheral or central portions. There were 4 cases of lesions with mixed high and low densities. Abundant @entity39 tissues were found with a rare vascular distribution.Or abundant fibers and connective tissues around @entity5 were manifested as @entity201 .One lesion showed equal density with abundant @entity39 tissue and fibrous connective tissue with @entity1263 tissue; dynamic contrast-enhanced CT: (1) there were 6 cases of lesion with peripheral thin ring-enhanced and @entity5 margin of viable @entity5 tissue. And internal @entity5 was fibrous tissue; (2) there were 7 cases of lesions with peripheral thick ring-enhanced and enhanced portion was surviving @entity5 tissue, no enhanced central portion was mainly @entity39 tissue mixed with little fibrous tissue; (3) there were 2 cases of @entity5 without enhancement. There were significant @entity548 and @entity39 with few surviving @entity5 cells in @entity5 and normal liver tissue; (4) there were 5 cases of lesions with heterogeneous enhancement and the heterogeneous enhancement portion was surviving @entity5 tissue and little fibrous connective tissue. And some @entity39 tissue remained; (5) only one case had overall enhancement of same-sized @entity5 cells without @entity39 . CONCLUSION: CT scanning of peripheral small @entity201 lacks distinguishing characteristics. However the findings of contrast-enhanced CT have certain characteristics. Due to different pathological types, each attribute has corresponding characteristic with different pathological features.

title: [Comparison study of small peripheral XXXX with computed tomographic and pathological findings].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1263 :: ('MESH:D010524', 'Disease') :: ['peripheral tumor']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['whole tumors', 'tumor']

entities_list: @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma', 'hardened cholangiocarcinoma']

entities_list: @entity1419 :: ('MESH:C535533', 'Disease') :: ['intrahepatic cholangiocarcinoma']

answer: @entity1419 :: (MESH:C535533,Disease) :: ['intrahepatic cholangiocarcinoma']


abstract: INTRODUCTION: When occurring in childhood, @entity21383 joint is responsible for complex @entity85 , including mandibular growth deficiency. We present a case of temporomandibular joint @entity3947 associated with severe mandibular asymmetry treated by mandibular bone distraction performed under computer assistance. OBSERVATION: A 27-year-old @entity1 presented with a severe @entity7439 consisting in @entity509 of the left hemi-mandible and maxilla. Mouth opening was non-existent. The CT-scan showed a left @entity21383 . A left mandibular distraction was decided. The distraction characteristics (choice and positioning of the distractor, @entity2270 and amount of distraction) were determined preoperatively on the 3D CT-scan. The planning has been transferred to a navigation console (Kolibri(  ), Brainlab(  )). A combined intraoral and cutaneous was performed. Navigation allowed for an appropriate placement of the osteotomy line and fixation of the distractor. Distraction was started at the 5th postoperative day at the rate of 1mm per day and lasted 25 days without complication. DISCUSSION: 3D planning allows for better indication setting, better preparation of the procedure, reducing complications and operative time. It may help as an educational tool for young surgeons and for a better understanding from the @entity1 . Navigation is an accurate method for the transfer of the planning in the operation room.

title: [3D mandibular distraction planification in a case of severe XXXX ].

entities_list: @entity21383 :: ('MESH:C536957', 'Disease') :: ['temporomandibular ankylosis']

entities_list: @entity3947 :: ('MESH:D000844', 'Disease') :: ['ankylosis']

entities_list: @entity509 :: ('MESH:C538429', 'Disease') :: ['hypoplasia']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['maxillofacial deformities']

entities_list: @entity7439 :: ('MESH:D005146', 'Disease') :: ['facial asymmetry']

answer: @entity21383 :: (MESH:C536957,Disease) :: ['temporomandibular ankylosis']


abstract: Background. The aim was to examine the association of @entity308 with fish eating habits, in elderly individuals. Methods. From June to October of 2009, we studied 330 @entity1 and 343 @entity1 , aged 65 to 100 years, permanent inhabitants of Ikaria Island. Among several characteristics, @entity308 was assessed with the Geriatric @entity308 scale (GDS range 0-15), while dietary habits through a valid semiquantitative food frequency questionnaire. Results. @entity1 had significantly higher values of the GDS compared to @entity1 (4.8    3.5 versus 3.3    3.1, P = .001). @entity1 in the upper tertile of @entity308 scale ate less frequent fish and consumed higher quantities of @entity167 , compared to those in the lowest tertile (all P < .05). Regarding fish consumption, 50% of the individuals reported consuming 1-2 times weekly, 32% 3 to 5 times weekly, 11% 2-3 times monthly, while the rest reported rare (4.5%) and everyday (1.2%) consumption. Logistic regression showed that increased fish consumption (>3 times/week versus never/rare) was inversely associated with the odds of having GDS greater the median value (i.e., 4) (odds      ratio = 0.34, 95% CI: 0.19, 0.61), after controlling for several cofounders. Conclusion. Frequent fish consumption in elderly seems to moderate @entity308 mood.

title: Fish Consumption Moderates Depressive Symptomatology in Elderly XXXX and @entity1 from the IKARIA Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Women', 'Participants', 'men']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depressive symptoms', 'depression']

answer: @entity1 :: (9606,Species) :: ['Men']


abstract: Background. The aim was to examine the association of @entity308 with fish eating habits, in elderly individuals. Methods. From June to October of 2009, we studied 330 @entity1 and 343 @entity1 , aged 65 to 100 years, permanent inhabitants of Ikaria Island. Among several characteristics, @entity308 was assessed with the Geriatric @entity308 scale (GDS range 0-15), while dietary habits through a valid semiquantitative food frequency questionnaire. Results. @entity1 had significantly higher values of the GDS compared to @entity1 (4.8    3.5 versus 3.3    3.1, P = .001). @entity1 in the upper tertile of @entity308 scale ate less frequent fish and consumed higher quantities of @entity167 , compared to those in the lowest tertile (all P < .05). Regarding fish consumption, 50% of the individuals reported consuming 1-2 times weekly, 32% 3 to 5 times weekly, 11% 2-3 times monthly, while the rest reported rare (4.5%) and everyday (1.2%) consumption. Logistic regression showed that increased fish consumption (>3 times/week versus never/rare) was inversely associated with the odds of having GDS greater the median value (i.e., 4) (odds      ratio = 0.34, 95% CI: 0.19, 0.61), after controlling for several cofounders. Conclusion. Frequent fish consumption in elderly seems to moderate @entity308 mood.

title: Fish Consumption Moderates Depressive Symptomatology in Elderly @entity1 and XXXX from the IKARIA Study.

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: AIM: Increased serum levels of the activated aspartic lysosomal endopeptidase @entity10815 ( @entity10815 ) have been found in @entity1 with @entity583 ( @entity583 ). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of @entity712 . This study aimed to evaluate the role of serum @entity10815 activity in the development of @entity712 in @entity1 with @entity583 ( @entity583 ). @entity1 AND METHODS: Eighty-eight consecutive @entity1 (79.5   % @entity1 , mean age 57.4        10.2  years) with @entity583 were included in this study. Serum @entity10815 activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. @entity1 were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal @entity583 , unplanned PCI, new-onset @entity712 , and @entity65 . RESULTS: Serum @entity10815 activity was significantly higher in @entity1 with @entity583 after PCI and during follow-up (FU) than that in age-matched controls (16.2        7.5 and 29.8        8.9 vs. 8.5        4.2 RFU; p   <   0.001 for each time point). At the 6-month follow-up, serum @entity10815 activity in these @entity1 was inversely related to new-onset @entity299 compared with @entity1 with preserved and improved LVEF after treatment (23.1        3.2 vs. 28.8        7.0 and 29.7        5.0 RFU respectively, p   <   0.01). @entity1 suffering from MACE during a follow-up period of 6  months had lower serum levels of activated @entity10815 than those without any MACE (23.8        4.6 vs 29.6        6.9 RFU; p   <   0.001). CONCLUSIONS: Serum @entity10815 activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in @entity1 with new-onset @entity299 , and lower levels of serum @entity10815 were associated with MACE at the 6-month post-MI follow-up.

title: Role of @entity10815 activation in major adverse cardiovascular events and new-onset XXXX after @entity583 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS', 'men']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['post-MI heart failure', 'heart failure']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['ST-segment elevation acute myocardial infarction', 'STEMI', 'AMI', 'myocardial infarction', 'acute myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: AIM: Increased serum levels of the activated aspartic lysosomal endopeptidase @entity10815 ( @entity10815 ) have been found in @entity1 with @entity583 ( @entity583 ). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of @entity712 . This study aimed to evaluate the role of serum @entity10815 activity in the development of @entity712 in @entity1 with @entity583 ( @entity583 ). @entity1 AND METHODS: Eighty-eight consecutive @entity1 (79.5   % @entity1 , mean age 57.4        10.2  years) with @entity583 were included in this study. Serum @entity10815 activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. @entity1 were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal @entity583 , unplanned PCI, new-onset @entity712 , and @entity65 . RESULTS: Serum @entity10815 activity was significantly higher in @entity1 with @entity583 after PCI and during follow-up (FU) than that in age-matched controls (16.2        7.5 and 29.8        8.9 vs. 8.5        4.2 RFU; p   <   0.001 for each time point). At the 6-month follow-up, serum @entity10815 activity in these @entity1 was inversely related to new-onset @entity299 compared with @entity1 with preserved and improved LVEF after treatment (23.1        3.2 vs. 28.8        7.0 and 29.7        5.0 RFU respectively, p   <   0.01). @entity1 suffering from MACE during a follow-up period of 6  months had lower serum levels of activated @entity10815 than those without any MACE (23.8        4.6 vs 29.6        6.9 RFU; p   <   0.001). CONCLUSIONS: Serum @entity10815 activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in @entity1 with new-onset @entity299 , and lower levels of serum @entity10815 were associated with MACE at the 6-month post-MI follow-up.

title: Role of XXXX activation in major adverse cardiovascular events and new-onset @entity712 after @entity583 .

answer: @entity10815 :: (1509,Gene) :: ['cathepsin D']


abstract: AIM: Increased serum levels of the activated aspartic lysosomal endopeptidase @entity10815 ( @entity10815 ) have been found in @entity1 with @entity583 ( @entity583 ). However, to date there have been no analyses of clinical follow-up data measuring the enzyme course and its role in the development of @entity712 . This study aimed to evaluate the role of serum @entity10815 activity in the development of @entity712 in @entity1 with @entity583 ( @entity583 ). @entity1 AND METHODS: Eighty-eight consecutive @entity1 (79.5   % @entity1 , mean age 57.4        10.2  years) with @entity583 were included in this study. Serum @entity10815 activity was measured directly after primary percutaneous coronary intervention (PCI), before discharge, and at the 6-month follow-up. @entity1 were monitored for major adverse cardiovascular events (MACE), defined as hospitalization due to cardiovascular causes, recurrent nonfatal @entity583 , unplanned PCI, new-onset @entity712 , and @entity65 . RESULTS: Serum @entity10815 activity was significantly higher in @entity1 with @entity583 after PCI and during follow-up (FU) than that in age-matched controls (16.2        7.5 and 29.8        8.9 vs. 8.5        4.2 RFU; p   <   0.001 for each time point). At the 6-month follow-up, serum @entity10815 activity in these @entity1 was inversely related to new-onset @entity299 compared with @entity1 with preserved and improved LVEF after treatment (23.1        3.2 vs. 28.8        7.0 and 29.7        5.0 RFU respectively, p   <   0.01). @entity1 suffering from MACE during a follow-up period of 6  months had lower serum levels of activated @entity10815 than those without any MACE (23.8        4.6 vs 29.6        6.9 RFU; p   <   0.001). CONCLUSIONS: Serum @entity10815 activity as a marker of healthy endogenous phagocytosis and remodeling was impaired in @entity1 with new-onset @entity299 , and lower levels of serum @entity10815 were associated with MACE at the 6-month post-MI follow-up.

title: Role of @entity10815 activation in major adverse cardiovascular events and new-onset @entity712 after XXXX .

answer: @entity583 :: (MESH:D009203,Disease) :: ['STEMI']


abstract: AIMS: The typical ultrasound features of @entity5123 are considered to be the well-defined contour, the regular, sometimes lobulated shape, homogeneous structure and poor vascularization. The goal of our study was to verify the validity of these features and to identify a typical sonoelastographic pattern for @entity5123 . @entity1 AND METHODS: Between April 2007 and February 2010, 70 salivary gland masses were examined prospectively (58 in the parotid gland, 12 in the submandibular gland). The following features were targeted: size, limits, contour, structure, echogenicity, vascularization, elasticity/stiffness. RESULTS: Of the 70 @entity5 , 32 (45.7%) were @entity5123 , 12 (17.1%) Warthin @entity5 , 9 (12.8%) other @entity5 , 13 (18.5%) primary @entity5 , 3 metastases from @entity189 , and 1 @entity1893 . Among @entity5123 , 15 (46.9%) were inhomogeneous, 7 (21.9%) contained @entity39 areas and 14 (43.7%) were well-vascularized. The lobulated contour was identified in 14 @entity5123 (43.7%), no other @entity5 presented this type of contour, but it was identified in 2 @entity5 (15.3%). On sonoelastography, most @entity5123 were heterogeneous. The elastic component represented more than 50% of the @entity5 tissue in 22 cases (68.7%). This aspect was also identified for 6 @entity5 (46.1%). CONCLUSIONS: Our results demonstrate that features such as heterogeneous structure, rich vascularization and intra-tumoral @entity39 may be identified in a significant number of @entity5123 . The most specific element in our group was the presence of a lobulated contour, which was not seen in any other @entity5 , but may rarely appear in certain @entity5 . The elastographic aspect was heterogeneous for most @entity5 , but the elastic composition identified in most @entity5123 was also present in a significant proportion of @entity5 . Therefore, a typical sonoelastographic pattern for @entity5123 could not be identified.

title: Ultrasonographic and sonoelastographic features of XXXX of the salivary glands.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumor', 'malignant tumors', 'benign tumors', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma']

entities_list: @entity5123 :: ('MESH:D008949', 'Disease') :: ['pleomorphic adenomas']

answer: @entity5123 :: (MESH:D008949,Disease) :: ['pleomorphic adenomas']


abstract: Working with animals on agricultural operations is hazardous for youths. This study evaluated the associations between activities and @entity130 related to specific animal types. A case-control study within the Regional Rural Injury Study II included 425 youths (less than 20 years of age) with @entity130 related to their operation and 1,886 controls (randomly selected youths). Exposures of interest were collected for the months prior to injury events for cases and randomly selected months for controls, based on an injury incidence algorithm. Multivariate logistic regression characterized associations between specific animal-related activities and injury outcomes among youths who reported working with the same animals. Large proportions of cases and controls, respectively, worked with beef @entity291 (47%, 28%), followed by @entity1641 (28%, 14%), and dairy @entity291 (22%, 12%). Feeding was the primary activity associated with animals; over 80% of cases and controls were involved in this activity during relevant exposure months, followed by milking (63%, 44%) among those working with dairy @entity291 and herding (81%, 61%) among beef @entity291 workers. Elevated risk of dairy @entity291 -related injury was associated with milking (odds ratio [OR]: 2.5; 95% confidence interval [CI]: 1.0-6.6) whereas beef @entity291 -related @entity130 were associated with calving (OR: 4.2; 95% CI: 2.1-8.6) and footwork (OR: 2.2; 95% CI: 1.0-4.9). Among youths working with animals, explicit activities can be identified that are associated with animal-specific @entity130 . The identification of relevant hazardous tasks is necessary for the development of effective prevention measures.

title: Animal-related activities as risk factors for XXXX among youth on agricultural operations.

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']

answer: @entity130 :: (MESH:D014947,Disease) :: ['injuries']


abstract: BACKGROUND: @entity1 who have suffered from @entity2806 have a high risk of recurrent vascular events. Predictive models based on classical risk factors typically have limited prognostic value. Given that @entity2806 has a heritable component, genetic information might improve performance of these risk models. Our aim was to develop and compare two models: one containing traditional vascular risk factors, the other also including genetic information. METHODS AND RESULTS: We studied 1020 @entity1 with @entity2806 and genotyped them with the Illumina Immunochip. Median follow-up time was 6.5 years; the annual incidence of new @entity63 events (primary outcome, n=198) was 3.0%. The prognostic model based on classical vascular risk factors had an area under the receiver operating characteristics curve (AUC-ROC) of 0.65 (95% confidence interval 0.61-0.69). When we added a genetic risk score based on prioritized SNPs from a genome-wide association study of @entity385 (using summary statistics from the METASTROKE study which included 12389 cases and 62004 controls), the AUC-ROC remained the same. Similar results were found for the secondary outcome @entity385 . CONCLUSIONS: We found no additional value of genetic information in a prognostic model for the risk of @entity63 events in @entity1 with @entity2806 of arterial origin. This is consistent with a complex, polygenic architecture, where many genes of weak effect likely act in concert to influence the heritable risk of an individual to develop (recurrent) vascular events. At present, genetic information cannot help clinicians to distinguish @entity1 at high risk for recurrent vascular events.

title: No Additional Prognostic Value of Genetic Information in the Prediction of Vascular Events after XXXX of Arterial Origin: The PROMISe Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['Cerebral Ischemia']


abstract: Dental @entity158 arises from exposed dentin following bacterial, chemical, or mechanical erosion of enamel and/or recession of gingiva. Thus, dentin tissue and more specifically patent dentinal tubules represent the first structure involved in dentin sensitivity. Interestingly, the architecture of dentin could allow for the transfer of information to the underlying dental pulp via odontoblasts (dentin-forming cells), via their apical extension bathed in the dentinal fluid running in the tubules, or via a dense network of trigeminal sensory axons intimately related to odontoblasts. Therefore, external stimuli causing dentinal fluid movements and odontoblasts and/or nerve complex responses may represent a unique mechanosensory system bringing a new role for odontoblasts as sensor cells. How cells sense signals and how the latter are transmitted to axons represent the main questions to be resolved. However, several lines of evidence have demonstrated that odontoblasts express mechano- and/or thermosensitive transient receptor potential ion channels ( @entity13812 , @entity22269 , @entity22268 , @entity23128 , @entity41857 , @entity22646 , @entity24351 ) that are likely to sense heat and/or cold or movements of dentinal fluid within tubules. Added to this, voltage-gated @entity1372 channels confer excitable properties of odontoblasts in vitro in response to injection of depolarizing currents. In vivo, @entity1372 channels co-localize with nerve terminals at the apical pole of odontoblasts and correlate with the spatial distribution of stretch-activated @entity22646 channels. This highlights the terminal web as the pivotal zone of the pulp/dentin complex for sensing external stimuli. Crosstalk between odontoblasts and axons may take place by the release of mediators in the gap space between odontoblasts and axons in view of evidence for nociception-transducing receptors on trigeminal afferent fibers and expression of putative effectors by odontoblasts. Finally, how axons are guided to the target cells and which kind of signaling molecules are involved is extensively discussed in this review.

title: Topical review. Dental XXXX and odontoblasts: facts and hypotheses.

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: The complex implantation process is initiated by the recognition and adhesion between the embryo and uterine endometrial epithelium. The expression and interactions between the adhesive molecules from both fetal and maternal sides are crucial for the successful implantation. In this study, we aimed to investigate the expression and adhesive function of sLeX on the trophoblasts and @entity1196 on uterine epithelial cells mediated the adhesion at the fetal-maternal interface, and to further explore whether this adhesion system could induce endometrial apoptosis, using in vitro implantation model consisting of the @entity1 trophoblast cell line (JAR) and @entity1 uterine epithelial cell line (RL95-2). The results showed that sLeX was expressed on JAR cells by indirect immunofluorescence staining. After transfection of JAR cells with @entity23521 ( @entity23521 ) which is the key enzyme for sLeX synthesis, the expression of @entity23521 and sLeX synthesis were increased, and the percent adhesion of trophoblast cells to @entity1 cell monolayer was significantly increased (P  <  0.01). @entity1196 was strongly expressed but not E- and @entity8729 on epithelial @entity1 cells by RT-PCR, Western blot. Blocking @entity1196 with specific antibody or heparin pretreatment in @entity1 cells inhibited the adhesion of JAR cells to @entity1 cell monolayer. Furthermore, regulating the expression of sLeX on JAR cells or blocking @entity1196 on @entity1 cells could activate the apoptosis of uterine epithelial cells. These results suggest the sLeX/ @entity1196 adhesion system at fetal-maternal interface not only mediates the adhesion of embryo to uterine epithelium, but also effectively induces the apoptosis in uterine epithelium. The study supplies a molecular basis for the elucidation of the initial recognition and adhesion during embryo implantation.

title: sLeX/ XXXX mediates adhesion in vitro implantation model.

entities_list: @entity23521 :: ('2529', 'Gene') :: ['FUT7', 'fucosyltransferase VII']

answer: @entity1196 :: (6402,Gene) :: ['L-selectin']


abstract: Immunosenescence involves age-associated restructuring changes of innate and adaptative immune functions. We have suggested that these changes of the immune system participate in the rate of ageing through modulating oxi-inflamm-ageing. Thus, age-related changes in the immune system can be biological age markers and predictors of longevity. Gender differences in oxidation status and immune functions have been observed in @entity35 , with males showing higher oxidation and immunosenescence than females of the same age. Oestrogens are sex hormones that actively participate in modulating the @entity1 immune function and, therefore, the age-related impairment of the immune response is drastically accelerated in females during the menopausal transition. Ovariectomy in rodents constitutes a good model for mimicking @entity1 oestrogen loss and thus the menopausal situation. Recently, we have shown the deleterious effects of @entity2931 loss on several functions of leukocytes from immune organs in @entity35 and @entity19 . In addition, ovariectomised @entity35 show similar levels in these immune functions to those in males. The present work studied several functions as well as inflammatory and oxidative stress parameters in @entity19 peritoneal macrophages and lymphocytes from old sham and ovariectomised females, as well as in males of the same age. In general, the results show that females, which have a higher immune response and a lower oxidation and @entity32 than males, appear similar to males in the parameters studied when they have lost oestrogens by ovariectomy. Thus, these data support the positive role of @entity2931 in the immune function through the ageing process.

title: Ovariectomy causes immunosenescence and oxi-inflamm-ageing in peritoneal leukocytes of aged female XXXX similar to that in aged males.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian', 'human']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen', 'oestrogens']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: Bevacizumab is a humanized monoclonal antibody that blocks vascular endothelial factor. It demonstrated an efficacy in many @entity5 types. The standard recommendation of administration is the 90-, 60-, and 30-min infusion sequence for all doses. We evaluated in this study the possibility of reducing infusion time to 10 min for bevacizumab given at 5 or 7.5 mg/kg in metastatic @entity14 (MCRC). @entity1 AND METHODS: All @entity1 who received bevacizumab for MCRC were analyzed. @entity1 were divided into two groups: Group A (bevacizumab was given in the 90-, 60-, and 30-min infusion sequence) and group B (bevacizumab was given over 10 min). @entity1 ' medical records were used to identify any @entity56 ( @entity56 ) possibly related to bevacizumab. RESULTS: There were 38 @entity1 in group A and 43 in group B. In group A, 459 doses of bevacizumab were given (286 doses at 5 mg/kg and 173 doses at 7.5 mg/kg). No @entity56 occurred in this group. In group B, 527 doses of bevacizumab were given (335 doses at 5 mg/kg and 192 doses at 7.5 mg/kg). Only two events of @entity56 grade 2 were reported in the 7.5 mg/kg infusions. Both of them were easily resolved with symptomatic treatment. CONCLUSIONS: Bevacizumab 5 or 7.5 mg/kg in MCRC can be infused safely over 10 min.

title: Bevacizumab 5 or 7.5 mg/kg in metastatic XXXX can be infused safely over 10 minutes.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['HSR', 'hypersensitivity reactions']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: CPFE-combined @entity3794 and @entity2415 is a new term for a syndrome whose main characteristic is @entity82 in @entity358 with simultaneous @entity2415 in @entity358 . CPFE @entity1 have well preserved pulmonary test values for unexpectedly long period, but extremely lowered @entity1223 diffusion capacity and significant arterial @entity101 . All CPFE studies indicate that CPFE occurs predominately in older male population. Smoking is considered main cause in developing CPFE. Reduced survival rate is linked with arterial @entity101 extent, and mortality rate is greater than that for @entity1 with isolated @entity3794 or @entity2415 . This study is focused on characteristics of twelve CPFE @entity1 . This paper describes cases of 12 @entity1 with the syndrome of @entity3794 associated with @entity2415 . All @entity1 were male, mean age of 68 years. At the certain period of life they all were smokers, but most of them were also exposed to air pollution due to their profession. Shortness of breath on exertion was present in all @entity1 . All @entity1 had neat pulmonary function tests with significantly reduced diffusing capacity for @entity505 mon- @entity8369 (average 39%). @entity120 ( @entity120 ) averaged 56 mmHg (range 25-75 mmHg) was present in 75% of @entity1 . Four @entity1 died during the period of four months, of which three @entity1 had @entity120 greater than 70 mmHg. The fourth @entity1 died of @entity2 .

title: [Combined XXXX and @entity2415 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['PAH', 'Pulmonary arterial hypertension']

entities_list: @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lower pulmonary lobes', 'upper pulmonary lobes']

answer: @entity3794 :: (MESH:D011658,Disease) :: ['pulmonary fibrosis']


abstract: CPFE-combined @entity3794 and @entity2415 is a new term for a syndrome whose main characteristic is @entity82 in @entity358 with simultaneous @entity2415 in @entity358 . CPFE @entity1 have well preserved pulmonary test values for unexpectedly long period, but extremely lowered @entity1223 diffusion capacity and significant arterial @entity101 . All CPFE studies indicate that CPFE occurs predominately in older male population. Smoking is considered main cause in developing CPFE. Reduced survival rate is linked with arterial @entity101 extent, and mortality rate is greater than that for @entity1 with isolated @entity3794 or @entity2415 . This study is focused on characteristics of twelve CPFE @entity1 . This paper describes cases of 12 @entity1 with the syndrome of @entity3794 associated with @entity2415 . All @entity1 were male, mean age of 68 years. At the certain period of life they all were smokers, but most of them were also exposed to air pollution due to their profession. Shortness of breath on exertion was present in all @entity1 . All @entity1 had neat pulmonary function tests with significantly reduced diffusing capacity for @entity505 mon- @entity8369 (average 39%). @entity120 ( @entity120 ) averaged 56 mmHg (range 25-75 mmHg) was present in 75% of @entity1 . Four @entity1 died during the period of four months, of which three @entity1 had @entity120 greater than 70 mmHg. The fourth @entity1 died of @entity2 .

title: [Combined @entity3794 and XXXX ].

answer: @entity2415 :: (MESH:D004646,Disease) :: ['emphysema syndrome']


abstract: AIM: The aim of the study was to identify the presence of @entity1005 ( @entity1005 ) in @entity1 who had sustained @entity8494 , additionally, we aimed to identify other variables that may modify the psychological response to @entity130 that include gender, age and presence of disfigurement post-treatment and visible scars/orthopedic injuries. MATERIALS AND METHODS: @entity1 comprised of 460 @entity1 from several multinodal @entity130 centers in Bengaluru City, Karnataka, who had sustained @entity8494 that had healed either with or without significant disfigurement or scarring and with visible/orthopedic injuries. One hundred and eleven @entity1 of the chosen 460 had sustained nondisfiguring @entity8494 while 153 @entity1 sustained disfiguring @entity8494 , 64 @entity1 who sustained @entity8494 (i.e. 19.5%) were lost to follow-up and were not included in the study. One hundred and thirty-two had sustained orthopedic/visible injuries; however, in this group, 18 (i.e. 13.6%) @entity1 were lost to follow-up and were excluded from the study. The impact of events scale (IES) was used to check the presence of @entity1005 . RESULTS: Statistically significant higher means of IES were present in @entity1 with disfiguring @entity8494 compared to nondisfiguring @entity8494 , female @entity1 compared to male @entity1 , @entity1 with disfiguring @entity8494 compared to orthopedic/visible injuries and @entity1 who were younger than 50 years of age compared to @entity1 who were older than 50 years of age and the results observed were similar at all three study intervals (date of discharge (DOD), 1 month and 6 months postoperatively). CONCLUSION: @entity1 with disfiguring @entity8494 had significantly higher @entity1005 levels compared to @entity1 with nondisfiguring @entity8494 , @entity1 with orthopedic/visible injuries had statistically significant lower IES scores which could not be strictly termed @entity1005 when compared to @entity1 with disfiguring @entity8494 who had high scores of IES corresponding to high levels of @entity1005 and these results were observed at all three study intervals (DOD, 1 and 6 months postoperatively). Female @entity1 with disfiguring @entity8494 had significantly higher @entity1005 levels compared to male @entity1 (at all the study intervals) and @entity1 younger than 50 years of age had significantly higher @entity1005 levels compared to older @entity1 .

title: @entity1005 in XXXX : A Comparative Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Participants']

entities_list: @entity8494 :: ('MESH:D005151', 'Disease') :: ['facial injury', 'facial injuries']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['post-traumatic stress disorder', 'PTSD']

answer: @entity8494 :: (MESH:D005151,Disease) :: ['Facial Injuries']


abstract: AIM: The aim of the study was to identify the presence of @entity1005 ( @entity1005 ) in @entity1 who had sustained @entity8494 , additionally, we aimed to identify other variables that may modify the psychological response to @entity130 that include gender, age and presence of disfigurement post-treatment and visible scars/orthopedic injuries. MATERIALS AND METHODS: @entity1 comprised of 460 @entity1 from several multinodal @entity130 centers in Bengaluru City, Karnataka, who had sustained @entity8494 that had healed either with or without significant disfigurement or scarring and with visible/orthopedic injuries. One hundred and eleven @entity1 of the chosen 460 had sustained nondisfiguring @entity8494 while 153 @entity1 sustained disfiguring @entity8494 , 64 @entity1 who sustained @entity8494 (i.e. 19.5%) were lost to follow-up and were not included in the study. One hundred and thirty-two had sustained orthopedic/visible injuries; however, in this group, 18 (i.e. 13.6%) @entity1 were lost to follow-up and were excluded from the study. The impact of events scale (IES) was used to check the presence of @entity1005 . RESULTS: Statistically significant higher means of IES were present in @entity1 with disfiguring @entity8494 compared to nondisfiguring @entity8494 , female @entity1 compared to male @entity1 , @entity1 with disfiguring @entity8494 compared to orthopedic/visible injuries and @entity1 who were younger than 50 years of age compared to @entity1 who were older than 50 years of age and the results observed were similar at all three study intervals (date of discharge (DOD), 1 month and 6 months postoperatively). CONCLUSION: @entity1 with disfiguring @entity8494 had significantly higher @entity1005 levels compared to @entity1 with nondisfiguring @entity8494 , @entity1 with orthopedic/visible injuries had statistically significant lower IES scores which could not be strictly termed @entity1005 when compared to @entity1 with disfiguring @entity8494 who had high scores of IES corresponding to high levels of @entity1005 and these results were observed at all three study intervals (DOD, 1 and 6 months postoperatively). Female @entity1 with disfiguring @entity8494 had significantly higher @entity1005 levels compared to male @entity1 (at all the study intervals) and @entity1 younger than 50 years of age had significantly higher @entity1005 levels compared to older @entity1 .

title: XXXX in @entity8494 : A Comparative Study.

answer: @entity1005 :: (MESH:D013313,Disease) :: ['Post-traumatic Stress Disorder']


abstract: BACKGROUND: @entity955 ( @entity3257 ) is an important risk factor for @entity63 ( @entity63 ). However, little is known about the characteristics of @entity63 @entity1 with @entity3257 . This study investigated the characteristics of such @entity1 , using data from a retrospective, observational, multicenter study. METHODS: @entity63 @entity1 admitted to 13 @entity64 centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between @entity1 with and without @entity3257 ( @entity3257 and @entity3257 ). RESULTS: A total of 464 @entity1 (292 @entity1 ; mean age 68.5    13.2 years) were registered. Of these, 79 @entity1 (17%) had @entity3257 . @entity1 in the @entity3257 group were older (73.9    9.1 vs. 67.4    13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and @entity2026 (9 vs. 3%, p = 0.007) than @entity1 in the non- @entity3257 group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion >= 15 mm (11 vs. 4%, p = 0.006), and a single lesion >= 15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the @entity3257 group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion >= 15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of @entity3257 . CONCLUSIONS: In this study, 17% of our @entity63 @entity1 had @entity3257 . We found an association between the @entity2806 pattern on DWI of a single lesion >= 15 mm and @entity3257 in @entity63 @entity1 . These results might lead to a better diagnosis of @entity63 @entity1 with @entity3257 .

title: Clinical Characteristics of @entity63 @entity1 with XXXX : Analyses of a Multicenter Retrospective Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['acute ischemic lesion']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['transient ischemic attack', 'TIA']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['Atrial fibrillation']

entities_list: @entity3257 :: ('MESH:C580335', 'Disease') :: ['AF', 'non-AF groups']

answer: @entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']


abstract: BACKGROUND: @entity955 ( @entity3257 ) is an important risk factor for @entity63 ( @entity63 ). However, little is known about the characteristics of @entity63 @entity1 with @entity3257 . This study investigated the characteristics of such @entity1 , using data from a retrospective, observational, multicenter study. METHODS: @entity63 @entity1 admitted to 13 @entity64 centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between @entity1 with and without @entity3257 ( @entity3257 and @entity3257 ). RESULTS: A total of 464 @entity1 (292 @entity1 ; mean age 68.5    13.2 years) were registered. Of these, 79 @entity1 (17%) had @entity3257 . @entity1 in the @entity3257 group were older (73.9    9.1 vs. 67.4    13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and @entity2026 (9 vs. 3%, p = 0.007) than @entity1 in the non- @entity3257 group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion >= 15 mm (11 vs. 4%, p = 0.006), and a single lesion >= 15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the @entity3257 group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion >= 15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of @entity3257 . CONCLUSIONS: In this study, 17% of our @entity63 @entity1 had @entity3257 . We found an association between the @entity2806 pattern on DWI of a single lesion >= 15 mm and @entity3257 in @entity63 @entity1 . These results might lead to a better diagnosis of @entity63 @entity1 with @entity3257 .

title: Clinical Characteristics of XXXX @entity1 with @entity955 : Analyses of a Multicenter Retrospective Study.

answer: @entity63 :: (MESH:D007511,Disease) :: ['Transient Ischemic Attack']


abstract: BACKGROUND: @entity955 ( @entity3257 ) is an important risk factor for @entity63 ( @entity63 ). However, little is known about the characteristics of @entity63 @entity1 with @entity3257 . This study investigated the characteristics of such @entity1 , using data from a retrospective, observational, multicenter study. METHODS: @entity63 @entity1 admitted to 13 @entity64 centers in Japan within 7 days of onset between January 2008 and December 2009 were included. The present analyses compared baseline characteristics, clinical symptoms, findings from diffusion-weighted imaging (DWI), and clinical outcomes between @entity1 with and without @entity3257 ( @entity3257 and @entity3257 ). RESULTS: A total of 464 @entity1 (292 @entity1 ; mean age 68.5    13.2 years) were registered. Of these, 79 @entity1 (17%) had @entity3257 . @entity1 in the @entity3257 group were older (73.9    9.1 vs. 67.4    13.6 years, p < 0.001) and more likely to show disturbance of consciousness (13 vs. 6%, p = 0.046) and @entity2026 (9 vs. 3%, p = 0.007) than @entity1 in the non- @entity3257 group. Although no difference in the overall DWI-positive rate was seen between the groups (28 vs. 20%, p = 0.102), a single lesion (23 vs. 10%, p < 0.001), a lesion >= 15 mm (11 vs. 4%, p = 0.006), and a single lesion >= 15 mm (11 vs. 2%, p < 0.001) on DWI were more frequent in the @entity3257 group. Multivariate logistic regression analysis identified increased age [odds ratio (OR) 1.04; 95% confidence interval (CI) 1.02-1.07] and DWI single lesion >= 15 mm (OR 5.67; 95% CI 1.92-16.7) as independently associated with the presence of @entity3257 . CONCLUSIONS: In this study, 17% of our @entity63 @entity1 had @entity3257 . We found an association between the @entity2806 pattern on DWI of a single lesion >= 15 mm and @entity3257 in @entity63 @entity1 . These results might lead to a better diagnosis of @entity63 @entity1 with @entity3257 .

title: Clinical Characteristics of @entity63 XXXX with @entity955 : Analyses of a Multicenter Retrospective Study.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: Thyroid @entity3 (TM) are uncommon. Dependent on study design, the reported frequency of TM is in the range of 0.1-6% in different analyses. While clinical and histopathological features of TM were well described in the literature, radiological publications consist predominantly of isolated case reports or small series. PURPOSE: To estimate the prevalence, clinical signs, and radiological appearances of TM. MATERIAL AND METHODS: From 1997 to 2013, a total of 8849 @entity1 with various disorders of the thyroid gland were treated in our institution. In 33 @entity1 TM were diagnosed. Ultrasound (US) images were available in all @entity1 , computed tomography (CT) of the neck in 16 @entity1 , and magnetic resonance imaging (MRI) in nine @entity1 . RESULTS: Clinically, most @entity1 (85%) presented with a painless neck mass. @entity5 were @entity1358 (79%), @entity14 (12%), @entity2 (3%), @entity980 (3%), and @entity0 (3%). On US, most lesions were irregular in shape with inhomogenous texture. On CT, all TM were hypodense. On T1-weighted images, most TM were inhomogenously iso-to-hyperintense in comparison to the normal thyroid tissue, and slightly hyperintense on T2-weighted images with an inhomogenous contrast enhancement. CONCLUSION: The prevalence of TM was 0.4%. Most of the TM originated from @entity1358 . The identified radiological features of TM should be taken into consideration in the differential diagnosis of @entity1374 .

title: Radiological features of XXXX to the thyroid.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Primary tumors']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity980 :: ('MESH:D012208', 'Disease') :: ['rhabdomyosarcoma']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid lesions']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastases']


abstract: INTRODUCTION: The QTc interval depends largely on cardiac repolarization since the duration of @entity299 is fairly constant in the normal heart. QTc at rest as well as during exercise has many clinical implications. In this study, we have compared the relative effects of dynamic and static exercise on QTc. AIM: To measure QTc interval in young @entity1 at rest and also assess how it is further modulated by submaximal dynamic and static exercises. MATERIALS AND METHODS: This observational study was conducted in the Department of Physiology on 30 non-obese young @entity1 randomly selected from the students of our institute after obtaining the consent and institutional ethical clearance. Continuous blood pressure monitoring and ECG recording was done in the subjects. Baseline (pre-exercise), post submaximal dynamic (Harvard's step test) and post submaximal static exercise (hand-grip exercise) recordings of @entity15032 and ECG were taken for analysis. The measured QT interval was corrected for heart rate using the formula of Bazett et al., {QTc=QT/RR(1/2)}.Statistical analysis was done using Graph pad Prism 5 software (California, USA). The baseline and post-exercise data were compared using paired t-test. A p<0.05 was taken to be statistical significant. RESULTS: There were statistically significant increases in HR, @entity13519 , @entity13520 and QTc interval after dynamic exercise in comparison to the baseline values (p<0.05). Significant increase in HR (p<0.05) with no significant change in QTc and other @entity65 were recorded following static exercise (p>0.05). CONCLUSION: Significant increase in QTc interval was observed after dynamic exercise, however, no change in QTc was observed following static exercise, and hence we conclude that static exercises may not be useful in assessing the cardiovascular status of an individual or in predicting @entity65 .

title: Effect of Sub Maximal Dynamic and Static Exercises on QTc interval in Healthy Young XXXX .

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac depolarization']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular parameters', 'cardiovascular events']

answer: @entity1 :: (9606,Species) :: ['Men']


abstract: BACKGROUND: @entity4710 are a known complication late after Fontan operation. Limited information is available on their prognostic value. METHODS: All @entity1 with previous Fontan operation followed at our institution since 1999 were identified from the electronic database and included in this study. Demographic and clinical characteristics including history of @entity4710 were recorded at the earliest full clinical assessment and @entity1 were followed thereafter for all-cause mortality and hospitalization. RESULTS: A total of 98 @entity1 , mean age 31.5    8.9 years, 43.8% male, 31.6% with a total cavopulmonary connection (TCPC) were identified. A history of @entity4710 was present at baseline in 60.2% of @entity1 who were older (33.0    8.3 vs 29.1    9.4 years, p=0.002), less likely to have a TCPC (13.5% vs 58.9%, p<0.001), and more symptomatic in terms of NYHA class (51.9% vs 26.7%, p=0.007) compared to @entity943 -free @entity1 . During a median follow-up of 6.7 years 18 @entity1 died and 64 @entity1 were hospitalized. Even after adjustment for baseline clinical characteristics, @entity4710 was an independent predictor of @entity204 (propensity score adjusted HR 9.35, 95% CI: 1.10-79.18, p=0.04, c-statistic 0.88) and composite of @entity204 or hospitalization (propensity score adjusted HR 5.00, 95% CI: 2.47-10.09, p<0.0001). CONCLUSIONS: In adult @entity1 with a Fontan-type operation, the presence of @entity4710 is associated with higher morbidity and mortality at mid-term follow-up. Whether early @entity943 targeting intervention may improve clinical outcome needs to be studied in a prospective manner.

title: XXXX late after Fontan operation are related to increase in mortality and hospitalization.

entities_list: @entity4710 :: ('MESH:D013617', 'Disease') :: ['Atrial tachyarrhythmias', 'atrial tachyarrhythmia', 'atrial tachyarrhythmias']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity4710 :: (MESH:D013617,Disease) :: ['Atrial tachyarrhythmias']


abstract: UNASSIGNED: Background: Dermoid cysts are frequent unilateral @entity5 that can be found at different locations throughout the body. In the orbital region, @entity48 occur predominantly in the supero-temporal quadrant. However, different orbital locations are possible, making this entity an important differential diagnosis for @entity5 . @entity1 and Methods: We retrospectively reviewed the charts of 23 consecutive @entity1 operated in our institution between 2005 and 2014 for @entity5 that were diagnosed as congenital dermoid or @entity4890 . Results: There were 21 dermoid and 2 @entity4890 . The median age at surgery time was 7 years (range 1-41). There were 15 females and 8 males. Eleven cysts were located supero-temporally (47.8%), seven supero-medially (30.4%), two temporally (8.7%), one at the frontal bone (4.4%) and two in the fossa of the lacrimal gland (8.7%). The mean cyst diameter was 13.1   mm      5.0 (SD). None had signs of @entity5 . No recurrence was observed after complete excision. Conclusion: Dermoid cysts of orbital region are mostly located in the supero-temporal quadrant. However, other orbital locations are possible and @entity48 must thus be considered in the differential diagnosis of any mass in the orbital region.

title: Different Locations of XXXX in the Orbital Region.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['orbital tumors', 'malignant disease', 'congenital benign tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4890 :: ('MESH:D004814', 'Disease') :: ['epidermoid cysts']

entities_list: @entity48 :: ('MESH:D003884', 'Disease') :: ['dermoid cysts']

answer: @entity48 :: (MESH:D003884,Disease) :: ['Dermoid Cysts']


abstract: OBJECTIVE: To evaluate treatment effectiveness (diet alone, insulin or @entity5217 ) on maternal weight @entity6677 (GDM). METHODS: GDM @entity1 were treated with diet alone, insulin or @entity5217 . @entity1017 was stratified into: prior to GDM diagnosis, from diagnosis to @entity1017 . Good glycemic control was defined as mean blood @entity413  <=105   mg/dl and @entity28 as Body Mass Index (BMI)   >=    30   kg/m(2), overweight BMI 25-29   kg/m(2) and normal <   25   kg/m(2). RESULTS: Total @entity1017 was similar in all the treatment groups. Two-thirds of @entity1017 occurred prior to diagnosis (diet 85%, insulin 67% and @entity5217 78%). Post-diagnosis, @entity1 on diet alone gained less weight than those on insulin or @entity5217 (p   <   0.001); insulin-treated @entity1 showed greater @entity1017 than @entity5217 -treated @entity1 (p   <   0.001). @entity1 on diet with good glycemic control showed less @entity1017 after diagnosis than @entity1 on insulin or @entity5217 (2.8        13, 6.6        10, 5.2        7.9 lbs, respectively, p   <   0.02). Poorly-controlled @entity1 , regardless of treatment, had similar patterns of @entity1017 throughout pregnancy. CONCLUSION: Patterns of maternal @entity1017 in GDM pregnancies are associated with treatment modality and level of glycemic control.

title: Weight XXXX : the effect of treatment modality.

entities_list: @entity6677 :: ('MESH:D016640', 'Disease') :: ['gain in gestational diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity5217 :: ('MESH:D005905', 'Chemical') :: ['glyburide']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['Weight gain', 'delivery and total pregnancy weight gain', 'weight gain']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6677 :: (MESH:D016640,Disease) :: ['gain in gestational diabetes']


abstract: Background. Vacuum-assisted closure (V.A.C.   Therapy, KCI, San Antonio, TX) has been widely used to increase the healing rate of a variety of wounds. It has been hypothesized that one of the actions of VAC is to increase perfusion and subsequent oxygenation of tissue. The aim of the present study was to investigate the effect of VAC therapy on transcutaneous oximetry measurements (TCOM) of skin surrounding chronic ven @entity3179 ETHODS: This was a prospective, experimental pilot study. Pat @entity1 dergoing compression therapy were recruited from a community wound clinic. All pat @entity1 d ankle-brachial pressure indices (ABPI) > 0.8. Three TCOM values were taken from around the ulc @entity1066 d a reference TCOM was taken from the chest. Negative pressure was applied on the ulc @entity1066 125-mmHg continuous subatmospheric pressure and four-layer compression bandaging over the VAC drapes. The duration of the study was 6 days. On day 6, dressings were removed and TCOM was repeated at the same skin sites. RESULTS: Fourteen of the 17 pat @entity1 mpleted the trial. The median age was 73 years (range 49-85). No significant difference was found in oxy @entity26 rtial pressure pre-and post-VAC therapy around the ulc @entity1066 te (mean 41.5 mmHg versus 40 mmHg [P = 0.67]). There was a significant difference in TCOM between the reference point and the periwound area (mean 60.5 versus 40 [P < 0.0005]). CONCLUSION: This pilot study suggests that VAC therapy does not change oxy @entity26 rtial pressure around ven @entity3179 COM of the skin around ulcers were low despite normal ABPIs.

title: The Effect of Vacuum-assisted Closure on the Tissue Oxygenation of Venous Ulcers: A P XXXX .

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous ulcers']

answer: @entity3179 :: (MESH:D014647,Disease) :: ['Venous Ulcers']