abstract: Three hundred and nine consecutive cases of @entity2075 due to @entity1756 --representing 34% of the total number of @entity1 with @entity439 observed in a 12-year period--were evaluated; of these, 211 were submitted to computed tomography scan. @entity1410 were present on admission in 71% of @entity1 and occurred at rebleeding in 29%. @entity438 caused an @entity2075 more frequently than @entity439 in other locations. Ventricular @entity1410 were frequently observed--especially at rebleeding--in cases with anterior communicating @entity438 . @entity21915 were detected in eight cases with internal carotid bifurcation @entity439 and in three with @entity438 . @entity3439 were observed in 32 cases, mainly due to @entity438 . As for clinical evolution, a rapid deterioration was observed in 39% of cases and a chronic course in 46%; a subacute deterioration was far less frequent. @entity245 from @entity2553 was observed in 8% of cases, and appeared to be related to the amount of @entity510 associated with the @entity1410 . One hundred and forty-two @entity1 were submitted to surgical treatment (evacuation of @entity1410 together with exclusion of @entity439 ); deep @entity772 , poor medical condition, stabilized @entity16 , or combinations of these factors accounted for the high number of @entity1 not operated upon. Regardless of treatment, 24% of @entity1 showed good results and 58% died. Presence of a large @entity1410 , @entity548 , and shift of the ventricles represented significant risk factors, associated with a poor prognosis. A comparison between two groups of @entity1 admitted within 3 days of @entity548 --47 operated on early, and 149 with delayed treatment--showed that better results were achieved by early operations, especially for cases in Hunt's grades IV and V.

title: Intracranial XXXX following @entity1756 : experience with 309 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3439 :: ('MESH:D006408', 'Disease') :: ['Subdural hematomas']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'ventricular hemorrhage']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['artery aneurysms', 'Ruptured middle cerebral artery aneurysms', 'middle cerebral artery aneurysms', 'ruptured middle-cerebral-artery and internal-carotid-artery aneurysms']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid bleeding']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disability']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['Delayed deterioration']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematoma', 'hematomas', 'Hematomas']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm', 'aneurysms']

entities_list: @entity2075 :: ('MESH:D020198', 'Disease') :: ['intracranial hematoma', 'intracranial hematomas']

entities_list: @entity21915 :: ('MESH:D020145', 'Disease') :: ['Basal ganglia hematomas']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['vasospasm']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['aneurysmal rupture']

answer: @entity1410 :: (MESH:D006406,Disease) :: ['hematomas']


abstract: Three hundred and nine consecutive cases of @entity2075 due to @entity1756 --representing 34% of the total number of @entity1 with @entity439 observed in a 12-year period--were evaluated; of these, 211 were submitted to computed tomography scan. @entity1410 were present on admission in 71% of @entity1 and occurred at rebleeding in 29%. @entity438 caused an @entity2075 more frequently than @entity439 in other locations. Ventricular @entity1410 were frequently observed--especially at rebleeding--in cases with anterior communicating @entity438 . @entity21915 were detected in eight cases with internal carotid bifurcation @entity439 and in three with @entity438 . @entity3439 were observed in 32 cases, mainly due to @entity438 . As for clinical evolution, a rapid deterioration was observed in 39% of cases and a chronic course in 46%; a subacute deterioration was far less frequent. @entity245 from @entity2553 was observed in 8% of cases, and appeared to be related to the amount of @entity510 associated with the @entity1410 . One hundred and forty-two @entity1 were submitted to surgical treatment (evacuation of @entity1410 together with exclusion of @entity439 ); deep @entity772 , poor medical condition, stabilized @entity16 , or combinations of these factors accounted for the high number of @entity1 not operated upon. Regardless of treatment, 24% of @entity1 showed good results and 58% died. Presence of a large @entity1410 , @entity548 , and shift of the ventricles represented significant risk factors, associated with a poor prognosis. A comparison between two groups of @entity1 admitted within 3 days of @entity548 --47 operated on early, and 149 with delayed treatment--showed that better results were achieved by early operations, especially for cases in Hunt's grades IV and V.

title: Intracranial @entity1410 following XXXX : experience with 309 cases.

answer: @entity1756 :: (MESH:D017542,Disease) :: ['aneurysmal rupture']


abstract: Recruitment, work load and morbidity linked to newborn @entity1763 during delivery at term: a study from Pediatric Mobile Intensive Care Units. OBJECTIVE: In a population of term neonates transported by the mobile intensive care units (MICU), we aimed to determine the incidence of neonates with @entity2806 related to @entity1763 , to analyze in this population the difficulties of management, and to try to identify which of these newborns require new therapeutic strategies. METHODS: This retrospective study was performed over a 2-year period (2000 and 2001) in 3 paediatric MICU from the Ile de France area. During this period, 7,648 @entity1 were transported including 3,301 newborns of more than 36 weeks of gestational age and less than 72 hours of life. These neonates came from 73 different hospitals. Among these 3,301 @entity1 , 237 neonates (124 @entity1 and 113 @entity1 ) with @entity2806 related to @entity1763 were selected in the present study. Inclusion criteria were association of one obligatory criterion of fetal distress during delivery and at least one criterion of @entity1763 or one criterion of @entity2806 . Data were compiled and analyzed with Epidata package and Epi info package, respectively. RESULTS: These 237 neonates with @entity63 represented 12% of MICU activity at the same gestational and postnatal ages. The mean gestational age was 39.5 + 1.5 weeks. The mean birth weight was 3,188 + 559 g. More than 50% of these neonates were born in level I maternities. Fifty-three percent of the @entity1 were born by caesarean section. Eighty-three percent of the neonates had an Apgar score at 1 minute <3. Eighty-eight percent of the neonates received resuscitation care at 5 minutes of life and 34% of these had an Apgar score at 10 minutes <5. In 50% of the cases, the MICUs arrived at the maternity of delivery within 1 h 45 min of life and transportation of the neonates was completed after 3 hours of life. The neonates were transported to an intensive care unit in 88% of the cases (half to a polyvalent intensive care unit and half to a neonatal intensive care unit). Forty-four percent of transported neonates had no @entity75 , 30% had a severe @entity75 or @entity410 , 27% had @entity881 . Mortality reached 28% and @entity75 accounted for two thirds of these deaths. Neonates who arrived in pediatric care units after 3 hours of life had more severe morbidity than neonates who arrived before 3 hours of life. CONCLUSION: Pediatric MICUs transport the most severely affected neonates. The initial clinical state is critical, and @entity149 are frequent and severe. Calls to the MICU should be made earlier in order to enable a better impact of new neuroprotective strategies.

title: [Newborn XXXX at term during delivery].

entities_list: @entity1 :: ('9606', 'Species') :: ['infants', 'girls', 'boys']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['anoxic-ischemic encephalopathy']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['anoxic-ischemic']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['systemic and neurological complications']

entities_list: @entity1763 :: ('MESH:D001237', 'Disease') :: ['neonatal asphyxia', 'asphyxia']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure']

answer: @entity1763 :: (MESH:D001237,Disease) :: ['asphyxia']


abstract: BACKGROUND: This study was performed to determine the echo layer structures of the normal gastric wall and early @entity356 when visualized with a 30-MHz ultrasonic miniprobe. METHODS: Twelve surgically resected gastric specimens were used for an ex vivo study. Eighteen normal sites and 12 early @entity356 sites were scanned with an Olympus (XUM-S30-25R) probe with a frequency of 30-MHz. Endoscopic ultrasound images were compared with corresponding histopathologic sections stained with @entity1710 and @entity1711 . RESULTS: The normal mucosa was visualized as at least four alternating echo layers; the muscularis mucosa was delineated at all normal sites. Lymphoid aggregates within the mucosa could be seen. The submucosa was clearly visualized in most cases, but the muscularis propria and subserosa were seldom depicted due to attenuation of ultrasound waves. At the sites of @entity356 , the layered architecture of the mucosa was disturbed by an irregular @entity75 . Minimal submucosal infiltration (400 and 750 micrometer) was clearly depicted in two cases, without @entity1066 at or around the @entity5 site. However, attenuation at the site of a deep @entity1066 scar prevented adequate visualization of the @entity5 extent in two other cases with @entity1066 . CONCLUSION: A 30-MHz ultrasonic miniprobe may provide additional imaging information of the gastric wall and could play a role in the assessment of early @entity5 .

title: Visualizing the gastric wall with a 30-MHz ultrasonic miniprobe: ex vivo imaging of normal gastric sites and sites of early XXXX .

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['hypoechoic lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer lesions']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulceration']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: BACKGROUND: We present the computed tomographic (CT) findings of @entity738 . METHODS: Five of 652 (0.9%) @entity1 who had undergone appendectomy for clinically suspected @entity697 over a 19-month period proved to have @entity738 . One @entity1 had surgery based on a clinical diagnosis of @entity697 . Four @entity1 (three @entity1 and one @entity1 ; age range = 14-39 years) underwent abdominal CT. The CT findings were retrospectively reviewed with special attention to the @entity854 . RESULTS: All four @entity1 presented with subacute clinical presentation. Enlarged appendices of 4.5 and 2 cm in diameter with thickened walls of soft tissue density were found in two @entity1 , and periappendicular inflammatory masses were found in the other two. Enlarged mesenteric lymph nodes and right lower quadrant fat stranding was seen in all four @entity1 . Histopathology showed numerous @entity738 within the inflamed appendix. CONCLUSION: Radiologists should be familiar with the rare entity of @entity738 in @entity1 examined by CT for suspected @entity697 . An insidious clinical presentation with CT findings of an exceptionally large appendix and associated periappendiceal inflammatory changes should raise the possibility of @entity738 or @entity189 or @entity706 .

title: XXXX presenting as right lower quadrant pain: CT findings.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient', 'men']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute appendicitis']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomatous appendicitis', 'granulomas']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma of the appendix']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['appendiceal abnormalities']

answer: @entity738 :: (MESH:D006099,Disease) :: ['Granulomatous appendicitis']


abstract: Although the thyroid gland itself is a major site of the autoimmune response, the study of T-cell function in @entity1669 has usually relied on peripheral blood as a source of cells. In this study, we have established thyroid-derived T-cell lines from six @entity1 with @entity2743 and one @entity1 with @entity2621 by culturing the thyroid lymphocytes on an autologous thyroid follicular cell monolayer in the presence of exogenous @entity1199 ( @entity1199 ). These T-cell lines have allowed in vitro investigation of thyroid-derived T-cell function, an approach which was previously limited by the number of lymphocytes obtained from the gland. The lines were predominantly OKT3, OKT4, and HLA-DR positive but showed heterogeneous proliferative responses. Some lines gave autologous or allogeneic mixed lymphocyte reactions but other did not. Only one of the seven lines responded well to the thyroid antigens thyroglobulin and microsomes presented by autologous monocytes. However, six of the lines proliferated in the presence of live but not dead autologous thyroid follicular cells, particularly when @entity379 ( @entity379 ) was added. This treatment has been shown to enhance HLA-DR and -DQ antigen expression by thyroid follicular cells in vitro. Furthermore, the proliferation induced by @entity379 -treated thyroid follicular cells was increased when thyroglobulin was also added. Together these results support the hypothesis that the expression of Ia antigens such as HLA-DR by thyroid follicular cells in @entity1669 may be important in enhancing the autoimmune response, conferring on these cells the ability to present thyroid autoantigens to T cells. The use of thyroid-derived T-cell lines should permit a more detailed evaluation of the disordered immuno-regulation in @entity2743 and @entity2621 than has been possible previously.

title: The production and characterization of thyroid-derived T-cell lines in XXXX and @entity2621 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ["Graves' disease"]

entities_list: @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease']

entities_list: @entity2621 :: ('MESH:D050031', 'Disease') :: ["Hashimoto's thyroiditis"]

entities_list: @entity379 :: ('3458', 'Gene') :: ['interferon-gamma', 'IFN-gamma']

answer: @entity2743 :: (MESH:D006111,Disease) :: ['Graves' disease']


abstract: Although the thyroid gland itself is a major site of the autoimmune response, the study of T-cell function in @entity1669 has usually relied on peripheral blood as a source of cells. In this study, we have established thyroid-derived T-cell lines from six @entity1 with @entity2743 and one @entity1 with @entity2621 by culturing the thyroid lymphocytes on an autologous thyroid follicular cell monolayer in the presence of exogenous @entity1199 ( @entity1199 ). These T-cell lines have allowed in vitro investigation of thyroid-derived T-cell function, an approach which was previously limited by the number of lymphocytes obtained from the gland. The lines were predominantly OKT3, OKT4, and HLA-DR positive but showed heterogeneous proliferative responses. Some lines gave autologous or allogeneic mixed lymphocyte reactions but other did not. Only one of the seven lines responded well to the thyroid antigens thyroglobulin and microsomes presented by autologous monocytes. However, six of the lines proliferated in the presence of live but not dead autologous thyroid follicular cells, particularly when @entity379 ( @entity379 ) was added. This treatment has been shown to enhance HLA-DR and -DQ antigen expression by thyroid follicular cells in vitro. Furthermore, the proliferation induced by @entity379 -treated thyroid follicular cells was increased when thyroglobulin was also added. Together these results support the hypothesis that the expression of Ia antigens such as HLA-DR by thyroid follicular cells in @entity1669 may be important in enhancing the autoimmune response, conferring on these cells the ability to present thyroid autoantigens to T cells. The use of thyroid-derived T-cell lines should permit a more detailed evaluation of the disordered immuno-regulation in @entity2743 and @entity2621 than has been possible previously.

title: The production and characterization of thyroid-derived T-cell lines in @entity2743 and XXXX .

answer: @entity2621 :: (MESH:D050031,Disease) :: ['Hashimoto's thyroiditis']


abstract: In practice, relapses of @entity5 after long time of surgical resection occur. However, few published data are available for duration, intensity and imaging sources of follow-up in radically excised @entity1 with @entity66 . Therefore, every single institution chooses the surveillance schedule according to its experience. The aim of this study was to describe the late recurrences of disease 5 years after the primary @entity5 's excision in a series of @entity1 with recurrent @entity677 from our institution. We retrospectively reviewed 42 @entity1 with "recurrent" @entity677 , collected since 2001. Ten @entity1 were always followed at our institution, and 32 @entity1 came to our attention at the time of recurrence. The analysed series were divided into two groups: @entity1 who developed recurrence before 5 years and @entity1 who developed recurrence 5 years after the primary @entity5 's excision. Among 42 @entity1 , 36 @entity1 developed the recurrence within 5 years of the primary @entity5 excision, whereas 6 @entity1 developed the recurrence 5 years after primary @entity5 excision diagnosed during follow-up or casually for other reasons. All @entity1 had distant recurrence, involving liver and peritoneum, whereas no local relapse was observed. These @entity1 were heterogeneous in primary @entity5 site, risk classification and molecular analysis. Duration of the follow-up for radically excised @entity1 with @entity677 remains still unsettled; however, the integration of every clinical, pathological and molecular parameter is essential to optimize the duration and intensity of the follow-up for each single @entity1 .

title: Late recurrences of @entity5 ( XXXX ) after 5 years of follow-up.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['gastrointestinal stromal tumours', 'tumour']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['localized disease']

answer: @entity5 :: (MESH:D009369,Disease) :: ['GISTs']


abstract: In practice, relapses of @entity5 after long time of surgical resection occur. However, few published data are available for duration, intensity and imaging sources of follow-up in radically excised @entity1 with @entity66 . Therefore, every single institution chooses the surveillance schedule according to its experience. The aim of this study was to describe the late recurrences of disease 5 years after the primary @entity5 's excision in a series of @entity1 with recurrent @entity677 from our institution. We retrospectively reviewed 42 @entity1 with "recurrent" @entity677 , collected since 2001. Ten @entity1 were always followed at our institution, and 32 @entity1 came to our attention at the time of recurrence. The analysed series were divided into two groups: @entity1 who developed recurrence before 5 years and @entity1 who developed recurrence 5 years after the primary @entity5 's excision. Among 42 @entity1 , 36 @entity1 developed the recurrence within 5 years of the primary @entity5 excision, whereas 6 @entity1 developed the recurrence 5 years after primary @entity5 excision diagnosed during follow-up or casually for other reasons. All @entity1 had distant recurrence, involving liver and peritoneum, whereas no local relapse was observed. These @entity1 were heterogeneous in primary @entity5 site, risk classification and molecular analysis. Duration of the follow-up for radically excised @entity1 with @entity677 remains still unsettled; however, the integration of every clinical, pathological and molecular parameter is essential to optimize the duration and intensity of the follow-up for each single @entity1 .

title: Late recurrences of XXXX ( @entity5 ) after 5 years of follow-up.

answer: @entity5 :: (MESH:D009369,Disease) :: ['gastrointestinal stromal tumours']


abstract: PURPOSE: In recent years there has been worldwide increase in childhood @entity28 . However, in the beginning laparoscopic appendectomy in @entity28 @entity1 was contraindicated, now it is commonly used for the treatment of @entity698 . The purpose of this study was to compare open versus laparoscopic @entity28 @entity1 . METHODS: The hospital records of 1,383 consecutive @entity1 , who underwent appendectomy for @entity697 between 2000 and 2009 were analyzed. 238 @entity1 (17.2%) were @entity28 . @entity28 was defined, as greater than 2 standard deviations above the standardized mean weight for age. 61 of 238 (25.6%) @entity1 had open appendectomy and 177 (74.3%) underwent laparoscopic appendectomy. The length of hospital stay, operation time, complication rate and frequency of taking @entity282 relief were compared between open and laparoscopic @entity28 @entity1 . RESULTS: The incidence of complicated and non-complicated @entity698 was similar both in open and laparoscopic appendectomy group. Laparoscopic appendectomy for @entity697 in @entity28 @entity1 is associated with significantly shorter operating time (46.8 vs. 59.87 min, P < 0.05), lower overall complication rate (5 vs. 8.2%, P < 0.05) and lesser postoperative analgesia requirement (6.97  vs. 4.73 , P < 0.05). CONCLUSION: Laparoscopic appendectomy should be the procedure of choice for the treatment of @entity697 in @entity28 @entity1 .

title: Laparoscopic appendectomy is associated with lower morbidity in extremely obese XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity698 :: ('MESH:D001064', 'Disease') :: ['appendicitis']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['appendectomy in extremely obese', 'obese', 'obesity', 'extremely obese', 'Extremely obese']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: The anti-anginal drug @entity1481 ( @entity2904 ) has been shown to increase the synthesis of phospholipids in ventricular myocytes, including @entity4357 (PI). This study focused on the consequences of increasing PI metabolism on alpha-adrenergic signaling pathway in cultured @entity35 cardiomyocytes. In the cells treated with @entity2904 , the synthesis of PI from @entity8580 was largely increased as compared with the control (+55% in 60 min). The stimulation of alpha-adrenergic receptors by @entity2647 (PE) induced a dose-dependent production of inositide @entity6546 (IPs) by phospholipase C (PLC) activation. However, the amount of available IPs was significantly lower in @entity2904 -treated cells, in a dose-dependent manner. This effect was observed in the presence and absence of the IP1-phosphatase inhibitor @entity4113 . The in vitro determination of PLC activity revealed that this effect could not be attributed to the direct inhibition of the enzyme by @entity2904 . The @entity2904 -induced reduction of IPs in the PE-stimulated cardiomyocytes should be attributed to the increase of @entity8580 recycling and incorporation in membrane structures, elicited by increased phospholipid synthesis. The consequences of this reduction in IPs availability were investigated on the cardiomyocyte @entity1184 induced by alpha-adrenergic chronic stimulation. Acute stimulation with PE increased protein synthesis (+50%), but this increase was largely prevented by @entity2904 . In conclusion, @entity2904 reduces cell available IPs, by accelerating their recycling in membranes as PI. This effect results in a cytoprotection in the pathological process of @entity1184 elicited by chronic alpha-adrenergic stimulation.

title: XXXX effect on phospholipid synthesis in ventricular myocytes: consequences in alpha-adrenergic signaling.

entities_list: @entity8580 :: ('MESH:D007294', 'Chemical') :: ['inositol']

entities_list: @entity6546 :: ('MESH:D010710', 'Chemical') :: ['phosphates']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

entities_list: @entity1481 :: ('MESH:D014292', 'Chemical') :: ['trimetazidine']

entities_list: @entity4357 :: ('MESH:D010716', 'Chemical') :: ['phosphatidyl-inositol']

answer: @entity1481 :: (MESH:D014292,Chemical) :: ['Trimetazidine']


abstract: The effect of a fermented soy milk product (FSP) on various @entity1 @entity0 cell lines was investigated, and it was shown to have a growth-inhibitory effect, especially on MCF-7 cells. Thus the MCF-7 cell line was used to study the mechanism of action. In female severe combined @entity3230 @entity19 implanted with MCF-7 cells, pretreatment with FSP significantly inhibited @entity5 growth. The inhibitory effect of FSP on MCF-7 cells seemed to be caused by the additive effects of a wide variety of constituents. The active components of FSP are mainly in the water phase, and the lipid-soluble fraction, which includes the soy @entity6400 such as @entity670 and @entity8139 , is relatively ineffective. A variety of methods were used to demonstrate that FSP caused apoptotic cell death in MCF-7 cells. FSP induced generation of reactive @entity26 species (ROS). Growth inhibition and ROS generation induced by FSP could be inhibited by catalase and @entity5532 , indicating that the ROS production probably was the cause of this apoptotic cell death. This study suggests that @entity5 growth in vivo and can trigger apoptosis in vitro. It may, therefore, be a potential nutritional supplement in chemotherapy.

title: Growth inhibition and induction of apoptosis in MCF-7 XXXX cells by fermented soy milk.

entities_list: @entity8139 :: ('MESH:C004742', 'Chemical') :: ['daidzein']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma']

entities_list: @entity5532 :: ('MESH:D003676', 'Chemical') :: ['deferoxamine']

entities_list: @entity670 :: ('MESH:D019833', 'Chemical') :: ['genistein']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'FSP retards tumor']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3230 :: ('MESH:C565469', 'Disease') :: ['immune deficiency']

entities_list: @entity6400 :: ('MESH:D007529', 'Chemical') :: ['isoflavones']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND AND OBJECTIVES: Inferior vena cava (IVC) @entity1822 are rare and are a relatively small subset of @entity242 . The current approach is resection and ligation or reconstruction of the IVC. This study was undertaken to analyze the outcomes associated with the use of neoadjuvant radiotherapy and IVC reconstruction in the treatment of @entity6323 . METHODS: A retrospective clinicopathological review of @entity1 treated during a 10-year period. RESULTS: Four @entity1 were treated with neoadjuvant radiotherapy, median 47.5   Gy, all underwent margin negative resection with 75% of the @entity5 being high grade and all @entity1 requiring resection of adjacent organs. Reconstruction of the IVC was performed with an autologous superficial femoral vein graft. There were no mortalities and the morbidity rate was 50%. At a median follow up of 37 months; two @entity1 had a patent IVC, no @entity1 had a local recurrence, and one @entity1 developed a distant @entity3 treated successfully with metastectomy. CONCLUSIONS: Neoadjuvant radiotherapy and resection of the @entity6323 resulted in 100% local control, and all @entity1 are alive at median follow up of 37 months. IVC reconstruction with the superficial femoral vein is safe and associated with acceptable short and long term morbidity.

title: Neoadjuvant radiotherapy and reconstruction using autologous vein graft for the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['retroperitoneal sarcomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity1822 :: ('MESH:D007890', 'Disease') :: ['leiomyosarcomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity6323 :: ('MESH:C563013', 'Disease') :: ['IVC leiomyosarcoma']

answer: @entity6323 :: (MESH:C563013,Disease) :: ['inferior vena cava leiomyosarcoma']


abstract: OBJECTIVES: @entity64 attributable to malignant @entity1313 is a rarely reported phenomenon and even various imaging techniques including angiography do not necessarily lead to an accurate diagnosis. CASE DESCRIPTION: A 46-year-old, previously healthy @entity1 developed apoplectic symptoms with slight right sided @entity1269 and @entity2026 . The computed tomography (CT) scan showed lesions of the left temporal lobe and the paraventricular white matter suggestive of @entity2500 . Carotid angiography demonstrated compression of the M1 segment of the MCA and occlusion of temporal MCA. The @entity1 initially refused magnetic resonance imaging (MRI) because of @entity913 . Because of fluctuating symptoms and successive worsening of the condition over weeks an MRI scan was conducted under general anaesthesia. Beneath temporal, opercular, and @entity1188 it revealed a left temporal @entity5 . A @entity5 biopsy disclosed a @entity3038 (WHO grade IV). Microscopical examination of the surgical specimen demonstrated invasion of @entity5 cells into the wall of a greater pre-existing blood vessel. CONCLUSIONS: Malignant @entity1313 may cause @entity1188 . This is a rare but important differential diagnosis for the origin of @entity64 . The authors describe the first case with infiltration of intracranial blood vessels by @entity5 cells of a @entity3038 .

title: A case of @entity3038 appearing as XXXX .

entities_list: @entity3038 :: ('MESH:D018316', 'Disease') :: ['gliosarcoma']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'Ischaemic stroke']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumour', 'brain tumours']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['left middle cerebral artery (MCA) infarction']

entities_list: @entity913 :: ('MESH:D010698', 'Disease') :: ['claustrophobia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity2026 :: ('MESH:D001037', 'Disease') :: ['global aphasia']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['ischaemic infarction', 'subcortical infarctions']

answer: @entity64 :: (MESH:D020521,Disease) :: ['ischaemic stroke']


abstract: OBJECTIVES: @entity64 attributable to malignant @entity1313 is a rarely reported phenomenon and even various imaging techniques including angiography do not necessarily lead to an accurate diagnosis. CASE DESCRIPTION: A 46-year-old, previously healthy @entity1 developed apoplectic symptoms with slight right sided @entity1269 and @entity2026 . The computed tomography (CT) scan showed lesions of the left temporal lobe and the paraventricular white matter suggestive of @entity2500 . Carotid angiography demonstrated compression of the M1 segment of the MCA and occlusion of temporal MCA. The @entity1 initially refused magnetic resonance imaging (MRI) because of @entity913 . Because of fluctuating symptoms and successive worsening of the condition over weeks an MRI scan was conducted under general anaesthesia. Beneath temporal, opercular, and @entity1188 it revealed a left temporal @entity5 . A @entity5 biopsy disclosed a @entity3038 (WHO grade IV). Microscopical examination of the surgical specimen demonstrated invasion of @entity5 cells into the wall of a greater pre-existing blood vessel. CONCLUSIONS: Malignant @entity1313 may cause @entity1188 . This is a rare but important differential diagnosis for the origin of @entity64 . The authors describe the first case with infiltration of intracranial blood vessels by @entity5 cells of a @entity3038 .

title: A case of XXXX appearing as @entity64 .

answer: @entity3038 :: (MESH:D018316,Disease) :: ['gliosarcoma']


abstract: The reaction of soil microorganisms to the contamination of soil artificially polluted with @entity2555 ( @entity2556 ) was evaluated in pot experiments. The plant used in the tests was cock's foot (Dactylis glomerata). Three different soils artificially contaminated with @entity2556 were applied in the studies. Three selected @entity2556 ( @entity10517 , @entity11966 , and @entity9435 ) were used at the doses of 100, 500, and 1000 mg/kg d.m. of soil and diesel fuel at the doses of 100, 500, and 1000 mg/kg d.m. of soil. For evaluation of the synergistic effect of @entity1568 fixing bacteria, the following strains were selected: associative Azospirillum spp. and @entity4190 stutzerii. Additionally, in the bioremediation process, the inoculation of plants with a mixture of the bacterial strains in the amount of 1 ml suspension per 500 g of soil was used. Chamber pot-tests were carried out in controlled conditions during four weeks of plant growth period. The basic physical, microbiological and biochemical properties in contaminated soils were determined. The obtained results showed a statistically important increase in the physical properties of soils polluted with @entity2556 and diesel fuel compared with the control and also an important decrease in the content of @entity2556 and heavy metals in soils inoculated with Azospirillum spp. and @entity4190 after cock's foot grass growth. The bioremediation processes were especially intensive in calcareous rendzina soil artificially polluted with @entity2556 .

title: Phytoremediation of XXXX in Soils Artificially Polluted Using Plant-Associated-Endophytic Bacteria and Dactylis glomerata as the Bioremediation Plant.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity10517 :: ('MESH:C034020', 'Chemical') :: ['anthracene']

entities_list: @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons']

entities_list: @entity4190 :: ('316', 'Species') :: ['Pseudomonas', 'P. stutzeri']

entities_list: @entity11966 :: ('MESH:C031181', 'Chemical') :: ['phenanthrene']

answer: @entity2555 :: (MESH:D011084,Chemical) :: ['Polycyclic Aromatic Hydrocarbons']


abstract: OBJECTIVE: To study the diagnosis and therapy of @entity10470 . METHOD: A total of 44 @entity1 with @entity10470 were received and cured in @entity1 's hospital of Wuhan University from 1990 to 2010. Two of them were bilateral carotid body @entity5 @entity1 . The operation were performed in all @entity1 to remove the @entity5 . Among these @entity1 , 39 of them were undertaken only @entity5 resecting, 6 were performed resecting of both @entity5 and external carotid artery and 1 were subjected to @entity5 resecting including internal carotid artery. RESULT: None of the @entity1 died after operation. In addition, none were detected @entity1158 except that 2 had temporary hoarseness. No recurrence were observed during a follow-up of 2-24 months. CONCLUSION: The most effective way to cure carotid body @entity5 is surgical operation. A better result may attribute to some key factors included adequate preoperative preparation, making sure the anatomic relationship with vessels and @entity162 under microscope.

title: [Diagnosis and treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar coagulation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity10470 :: ('MESH:D002345', 'Disease') :: ['carotid body tumors']

answer: @entity10470 :: (MESH:D002345,Disease) :: ['carotid body tumors']


abstract: UNASSIGNED: Multichannel processing of environmental information constitutes a fundamental basis of functioning of sensory systems in the vertebrate brain. Two distinct parallel visual systems - the tectofugal and thalamofugal exist in all amniotes. The vertebrate central nervous system contains high concentrations of intracellular @entity460 -binding proteins (CaBPrs) and each of them has a restricted expression pattern in different brain regions and specific neuronal subpopulations. This study aimed at describing the patterns of distribution of @entity72375 (PV) and @entity72376 ( @entity72376 ) in the visual thalamic and mesencephalic centers of the pigeon ( @entity22036 ). We used a combination of immunohistochemistry and double labeling immunofluorescent technique. Structures studied included the thalamic relay centers involved in the tectofugal (nucleus rotundus, Rot) and thalamofugal (nucleus geniculatus lateralis, pars dorsalis, GLd) visual pathways as well as pretectal, mesencephalic, isthmic and thalamic structures inducing the driver and/or modulatory action to the visual processing. We showed that neither of these proteins was unique to the Rot or GLd. The Rot contained i) numerous PV-immunoreactive (ir) neurons and a dense neuropil, and ii) a few @entity72376 -ir neurons mostly located in the anterior dorsal part and associated with a light neuropil. These latter neurons partially overlapped with the former and some of them colocalized both proteins. The distinct subnuclei of the GLd were also characterized by different patterns of distribution of CaBPrs. Some (nucleus dorsolateralis anterior, pars magnocellularis, DLAmc; pars lateralis, DLL; pars rostrolateralis, DLAlr; nucleus lateralis anterior thalami, LA) contained both @entity72376 - and PV-ir neurons in different proportions with a predominance of the former in the DLAmc and DLL. The nucleus lateralis dorsalis of nuclei optici principalis thalami only contained PV-ir neurons and a neuropil similar to the interstitial pretectal/thalamic nuclei of the tectothalamic tract, nucleus pretectalis and thalamic reticular nucleus. The overlapping distribution of PV and @entity72376 immunoreactivity was typical for the pretectal nucleus lentiformis mesencephali and the the nucleus ectomamillaris as well as for the visual isthmic nuclei. The findings are discussed in the light of the contributive role of the phylogenetic and functional factors determining the circuits' specificity of the different CaBPr types.

title: Distribution of XXXX -binding proteins in the pigeon visual thalamic centers and related pretectal and mesencephalic nuclei. Phylogenetic and functional determinants.

entities_list: @entity22036 :: ('8932', 'Species') :: ['Columba livia']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: UNASSIGNED: Currently, the lack of awareness of deficits, i.e., @entity1054 , is a major obstacle in the healthcare circuit that delays the diagnosis of @entity195 ( @entity195 ). However, a clear framework is lacking in the literature related to this phenomenon in terms of its definition, mechanisms, and objects. The aim of this study is to assess the different levels of @entity73 using a prediction-performance procedure and to identify the potential correlates of these levels. A  sample of @entity1 with probable @entity195 was divided into three groups according to the severity of @entity303 (mild (MiD), moderate (MoD), and moderately severe ( @entity11159 ) @entity303 ), ranked according to the results of the Mini-Mental State Examination. We observed the following three scores: the real score, the prediction score, and the @entity1054 score. These scores were calculated based on the prediction-performance task MISAwareness from the @entity303 Rating Scale for cognitive processes (i.e., Attention, Initiation, Conceptualization, Construction, and Memory). We obtained a strong plateau effect between the MiD and MoD groups for @entity1054 scores for actual performance or prediction for both the level of overall functioning and for specific processes. The sole exception was the result for memory processes. Moreover, the profiles of the @entity1 ' responses on the Memory subscale were substantially different and, indeed, opposite from those for the other processes. The main results confirm the multidimensionality of @entity1054 and its variability with the stage of @entity303 and specifically implicate memory processes that indicate a cleavage between memory and other cognitive functions.

title: Heterogeneity of XXXX and  its Variation with the Severity of  @entity303 in @entity1 with @entity195 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['Dementia', 'dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive anosognosia']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['anosognosia']

answer: @entity73 :: (MESH:D003072,Disease) :: ['Cognitive Anosognosia']


abstract: UNASSIGNED: Currently, the lack of awareness of deficits, i.e., @entity1054 , is a major obstacle in the healthcare circuit that delays the diagnosis of @entity195 ( @entity195 ). However, a clear framework is lacking in the literature related to this phenomenon in terms of its definition, mechanisms, and objects. The aim of this study is to assess the different levels of @entity73 using a prediction-performance procedure and to identify the potential correlates of these levels. A  sample of @entity1 with probable @entity195 was divided into three groups according to the severity of @entity303 (mild (MiD), moderate (MoD), and moderately severe ( @entity11159 ) @entity303 ), ranked according to the results of the Mini-Mental State Examination. We observed the following three scores: the real score, the prediction score, and the @entity1054 score. These scores were calculated based on the prediction-performance task MISAwareness from the @entity303 Rating Scale for cognitive processes (i.e., Attention, Initiation, Conceptualization, Construction, and Memory). We obtained a strong plateau effect between the MiD and MoD groups for @entity1054 scores for actual performance or prediction for both the level of overall functioning and for specific processes. The sole exception was the result for memory processes. Moreover, the profiles of the @entity1 ' responses on the Memory subscale were substantially different and, indeed, opposite from those for the other processes. The main results confirm the multidimensionality of @entity1054 and its variability with the stage of @entity303 and specifically implicate memory processes that indicate a cleavage between memory and other cognitive functions.

title: Heterogeneity of @entity73 and  its Variation with the Severity of  @entity303 in @entity1 with XXXX .

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']


abstract: UNASSIGNED: Currently, the lack of awareness of deficits, i.e., @entity1054 , is a major obstacle in the healthcare circuit that delays the diagnosis of @entity195 ( @entity195 ). However, a clear framework is lacking in the literature related to this phenomenon in terms of its definition, mechanisms, and objects. The aim of this study is to assess the different levels of @entity73 using a prediction-performance procedure and to identify the potential correlates of these levels. A  sample of @entity1 with probable @entity195 was divided into three groups according to the severity of @entity303 (mild (MiD), moderate (MoD), and moderately severe ( @entity11159 ) @entity303 ), ranked according to the results of the Mini-Mental State Examination. We observed the following three scores: the real score, the prediction score, and the @entity1054 score. These scores were calculated based on the prediction-performance task MISAwareness from the @entity303 Rating Scale for cognitive processes (i.e., Attention, Initiation, Conceptualization, Construction, and Memory). We obtained a strong plateau effect between the MiD and MoD groups for @entity1054 scores for actual performance or prediction for both the level of overall functioning and for specific processes. The sole exception was the result for memory processes. Moreover, the profiles of the @entity1 ' responses on the Memory subscale were substantially different and, indeed, opposite from those for the other processes. The main results confirm the multidimensionality of @entity1054 and its variability with the stage of @entity303 and specifically implicate memory processes that indicate a cleavage between memory and other cognitive functions.

title: Heterogeneity of @entity73 and  its Variation with the Severity of  XXXX in @entity1 with @entity195 .

answer: @entity303 :: (MESH:D003704,Disease) :: ['Dementia']


abstract: UNASSIGNED: Currently, the lack of awareness of deficits, i.e., @entity1054 , is a major obstacle in the healthcare circuit that delays the diagnosis of @entity195 ( @entity195 ). However, a clear framework is lacking in the literature related to this phenomenon in terms of its definition, mechanisms, and objects. The aim of this study is to assess the different levels of @entity73 using a prediction-performance procedure and to identify the potential correlates of these levels. A  sample of @entity1 with probable @entity195 was divided into three groups according to the severity of @entity303 (mild (MiD), moderate (MoD), and moderately severe ( @entity11159 ) @entity303 ), ranked according to the results of the Mini-Mental State Examination. We observed the following three scores: the real score, the prediction score, and the @entity1054 score. These scores were calculated based on the prediction-performance task MISAwareness from the @entity303 Rating Scale for cognitive processes (i.e., Attention, Initiation, Conceptualization, Construction, and Memory). We obtained a strong plateau effect between the MiD and MoD groups for @entity1054 scores for actual performance or prediction for both the level of overall functioning and for specific processes. The sole exception was the result for memory processes. Moreover, the profiles of the @entity1 ' responses on the Memory subscale were substantially different and, indeed, opposite from those for the other processes. The main results confirm the multidimensionality of @entity1054 and its variability with the stage of @entity303 and specifically implicate memory processes that indicate a cleavage between memory and other cognitive functions.

title: Heterogeneity of @entity73 and  its Variation with the Severity of  @entity303 in XXXX with @entity195 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: @entity1164 ( @entity1164 ) accounts for approximately 15-20% of all @entity204 worldwide. While the majority of SCDs occur in adults, @entity1 , and adults <35 years (<1%) may also be affected. Currently the most effective strategy for both primary and secondary prevention of @entity1164 is the @entity737 ( @entity737 ). However, identification of @entity1 who will benefit from @entity737 implantation remains challenging. @entity1002 ( @entity1002 ) is the most frequent imaging parameter used to select @entity1 for @entity737 implantation for primary prevention. However, @entity1002 has shown to be suboptimal for prediction of benefit. Non-invasive cardiac imaging permits characterization of the arrhythmogenic substrate, including dispersion of electromechanical activation, presence of @entity296 , and cardiac innervation status. The arrhythmogenic substrate may change across the different underlying diseases. While in @entity296 , differentiation and characterization of @entity1188 core and peri- @entity1188 zone have been shown to refine the risk stratification of @entity1 , in non-ischemic @entity296 , the substrate may be more heterogeneous and tissue characterization assessing focal and diffuse @entity82 and @entity32 processes may be more relevant. Furthermore, in channelopathies, assessment of mechanical dispersion between @entity296 may identify the @entity1 with increased risk of @entity943 . Finally, potential triggers of @entity943 such as @entity741 can be evaluated. The role of noninvasive imaging in the risk stratification of @entity1164 and the selection of candidates for @entity737 will be discussed in this article.

title: Noninvasive imaging markers associated with XXXX .

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['Sudden cardiac death', 'SCD']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathies', 'myocardial scar', 'ischemic cardiomyopathy', 'myocardial layers']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias']

entities_list: @entity737 :: ('MESH:D057873', 'Disease') :: ['ICD', 'implantable cardioverter-defibrillator']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['Left ventricular ejection fraction', 'LVEF']

answer: @entity1164 :: (MESH:D016757,Disease) :: ['sudden cardiac death']


abstract: CONTEXT: Exercise could be beneficial for @entity263 survivors. However, no systematic review across @entity5 stages and treatment types addressing potential benefits and harms exists to date. OBJECTIVE: To assess the effects of exercise on @entity5 -specific quality of life and adverse events in @entity263 trials. EVIDENCE ACQUISITION: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, AMED, CINAHL, PsycINFO, SPORTDiscus, and PEDro. We also searched grey literature databases, including trial registers. Searches were from database inception to March 2015. Standardised mean differences (SMDs) were calculated for meta-analysis. EVIDENCE SYNTHESIS: We included 16 randomised controlled trials (RCTs) involving 1574 @entity1 with @entity263 . Follow-up varied from 8 wk to 12 mo. RCTs involved @entity1 with stage I-IV @entity5 . A high risk of bias was frequently due to problematic intervention adherence. Seven trials involving 912 @entity1 measured @entity5 -specific quality of life. Pooling of the data from these seven trials revealed no significant effect on this outcome ( @entity7126 0.13, 95% confidence interval [CI] -0.08 to 0.34, median follow-up 12 wk). Sensitivity analysis of studies that were judged to be of high quality indicated a moderate positive effect estimate ( @entity7126 0.33, 95% CI 0.08-0.58; median follow-up 12 wk). Similar beneficial effects were seen for @entity5 , submaximal @entity410 , and lower body strength. We found no evidence of benefit for disease progression, @entity65 , or sexual function. There were no deaths attributable to exercise interventions. Other serious adverse events (eg, @entity583 ) were equivalent to those seen in controls. CONCLUSIONS: These results support the hypothesis that exercise interventions improve @entity5 -specific quality of life, @entity5 , submaximal @entity410 , and lower body strength. @entity1 SUMMARY: This review shows that exercise/physical activity interventions can improve quality of life, @entity1295 , @entity410 , and function for @entity1 with @entity263 .

title: Exercise for @entity1 with XXXX : A Systematic Review and Meta-analysis.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'cancer-specific fatigue']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular health']

answer: @entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']


abstract: CONTEXT: Exercise could be beneficial for @entity263 survivors. However, no systematic review across @entity5 stages and treatment types addressing potential benefits and harms exists to date. OBJECTIVE: To assess the effects of exercise on @entity5 -specific quality of life and adverse events in @entity263 trials. EVIDENCE ACQUISITION: We searched the Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, AMED, CINAHL, PsycINFO, SPORTDiscus, and PEDro. We also searched grey literature databases, including trial registers. Searches were from database inception to March 2015. Standardised mean differences (SMDs) were calculated for meta-analysis. EVIDENCE SYNTHESIS: We included 16 randomised controlled trials (RCTs) involving 1574 @entity1 with @entity263 . Follow-up varied from 8 wk to 12 mo. RCTs involved @entity1 with stage I-IV @entity5 . A high risk of bias was frequently due to problematic intervention adherence. Seven trials involving 912 @entity1 measured @entity5 -specific quality of life. Pooling of the data from these seven trials revealed no significant effect on this outcome ( @entity7126 0.13, 95% confidence interval [CI] -0.08 to 0.34, median follow-up 12 wk). Sensitivity analysis of studies that were judged to be of high quality indicated a moderate positive effect estimate ( @entity7126 0.33, 95% CI 0.08-0.58; median follow-up 12 wk). Similar beneficial effects were seen for @entity5 , submaximal @entity410 , and lower body strength. We found no evidence of benefit for disease progression, @entity65 , or sexual function. There were no deaths attributable to exercise interventions. Other serious adverse events (eg, @entity583 ) were equivalent to those seen in controls. CONCLUSIONS: These results support the hypothesis that exercise interventions improve @entity5 -specific quality of life, @entity5 , submaximal @entity410 , and lower body strength. @entity1 SUMMARY: This review shows that exercise/physical activity interventions can improve quality of life, @entity1295 , @entity410 , and function for @entity1 with @entity263 .

title: Exercise for XXXX with @entity263 : A Systematic Review and Meta-analysis.

answer: @entity1 :: (9606,Species) :: ['Men']


abstract: Dystrophinopathies are due to mutations in the @entity4714 gene on chromosome Xp21.1 and comprise the allelic entities @entity1555 ( @entity1555 ), @entity1555 ( @entity1555 ) and @entity34195 ( @entity34195 ). In all three entities, the heart is affected to various degrees, depending on the stage of the disease and the type of the mutation (cardiac involvement, CI). The pathoanatomic evidence of CI in dystrophinopathies is the replacement of myocardium by connective tissue or fat. In @entity1555 / @entity1555 , the left ventricular posterobasal and lateral walls are most extensively affected, sparing the right ventricle and the atrium. Degree and dynamics of CI vary among the three entities. In @entity1555 / @entity1555 , CI usually remains subclinical in the early stages of the disease. Typical initial manifestations of CI in @entity1555 / @entity1555 are @entity7129 , tall R1 in V1, prominent Q in I, aVL, V6 or in II, III, and aVF, @entity1162 and possibly @entity5433 . Initially, echocardiography is normal or shows regional wall motion abnormalities in areas of @entity82 . With spreading of @entity82 , @entity1002 and @entity943 additionally occur. In the final stages of the disease, systolic function may lead to @entity712 and @entity944 . Subclinical or clinical CI is present in about 90% of the @entity1555 / @entity1555 @entity1 but is the cause of @entity204 in only 20% of the @entity1555 and 50% of the @entity1555 @entity1 . @entity34195 is a rapidly progressive, almost exclusively @entity296 , starting in teenage males as @entity712 due to dilative @entity296 ( @entity296 ), leading to @entity204 from intractable @entity712 within 1-2 years after diagnosis. Therapy of @entity943 and @entity296 in all three disorders follows the established cardiological recommendations. Due to its protective effect, ACE inhibitors are recommended already at the early stages of the disease. Beta-blockers may be an additional option if indicated.

title: The heart in XXXX dystrophinopathies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'arrhythmias']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'myocardial disorder', 'CMP']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ['BMD', 'Becker muscular dystrophy', 'Duchenne muscular dystrophy', 'DMD']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['increased QT dispersion']

entities_list: @entity7129 :: ('MESH:D013616', 'Disease') :: ['sinus tachycardia']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular dysfunction']

entities_list: @entity34195 :: ('OMIM:302045', 'Disease') :: ['X-linked dilative cardiomyopathy', 'XLDCM']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: In cadaveric liver transplantation, the Milan criteria have been accepted as the selection criteria for @entity157 ( @entity157 ) @entity1 in considering organ allocation. However, the situation is different in living-donor liver transplantation (LDLT), in which the donor has a strong preference for altruism. The authors describe herein their experience with LDLT for @entity157 @entity1 using their @entity1 selection criteria. From February 1999 to March 2002, right lobe LDLT was performed in 56 @entity1 with @entity157 . The authors' exclusion criteria included only those with extrahepatic @entity3 or vascular invasion detected during preoperative evaluation. Thirty @entity1 (54%) were in @entity5 , node, @entity3 stage IVa and 25 @entity1 (45%) did not meet the Milan criteria at the time of LDLT. The follow-up period was 1 to 39 months (median, 11 months). The overall survival rates at 1 and 3 years were 73% and 55%, respectively, and the latter was significantly lower than that of adult right lobe LDLT without @entity157 (71% at 3 years). Fourteen @entity1 died because of @entity260 without @entity5 recurrence. Thirty-six @entity1 survived without recurrence and six @entity1 had recurrence. Among the six @entity1 with recurrence, four had survived for 11 to 36 months after LDLT. In the analysis of @entity1 who survived longer than 3 months after transplantation, 19 of 20 within the Milan criteria survived without recurrence. However, 15 of 20 @entity1 beyond the criteria also survived without recurrence for 3 to 33 months (median, 12 months) and three of five @entity1 with recurrence were alive for 11 to 36 months (median, 20 months). Histopathologic grading and microscopic portal venous invasion had significant negative impact on @entity5 recurrence. LDLT was an effective treatment for uncontrollable @entity157 . Because many @entity1 who did not meet the Milan criteria survived without @entity5 recurrence after transplantation, different @entity1 selection criteria are necessary in LDLT to save those with advanced @entity157 .

title: Living-donor liver transplantation for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: PURPOSE OF REVIEW: This review analyses the recently published literature focusing on nutritional assessment in intensive care unit @entity1 . The metabolic response to nutritional intervention is difficult to evaluate in critically ill @entity1 whose body weight is influenced largely by massive fluid administration or losses. Visceral protein plasma levels have been proposed for this purpose, because they reflect hepatic synthesis in response to nutrient supply. However, in acute inflammatory states, liver activity is converted to the synthesis of acute-phase response proteins, resulting in a dramatic drop in visceral proteins, despite nutritional support. RECENT FINDINGS: The data regarding visceral protein levels were examined in relation to nutritional supplementation, and compared with other nutritional parameters and clinical outcomes. @entity20117 and @entity904 -binding protein levels seem to be the most sensitive to nutritional intervention. They are also the earliest to rise at the decrease of acute-phase protein levels, therefore representing a good index of the reversing reprioritization of hepatic protein synthesis. An inconsistent relationship was found between visceral protein plasma levels and clinical outcome in intensive care unit @entity1 , probably because of the difficulty in demonstrating clearly a beneficial effect of nutritional supplementation in highly catabolic conditions. SUMMARY: In the acute stage of @entity3124 , the bi-weekly measurement of @entity20117 together with acute-phase response protein plasma levels seems to be a 'window' on the metabolic condition (anabolism versus catabolism). However, only in the presence of stable inflammatory parameters do @entity20117 levels reflect the adequacy of nutritional coverage.

title: The role of visceral proteins in the nutritional assessment of intensive care unit XXXX .

entities_list: @entity20117 :: ('7276', 'Gene') :: ['transthyretin', 'Transthyretin']

entities_list: @entity904 :: ('MESH:D014801', 'Chemical') :: ['retinol']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: Spontaneous dissection of the carotid and vertebral arteries represents a rare pathology. Its pathogenesis, probably multi-factorial, can be related to neck @entity130 and to a genetic basis, extensively demonstrated in the cases of association with type IV @entity4267 , @entity4243 , @entity1614 , @entity12977 and @entity6926 . Onset symptoms include neck, @entity158 and @entity10 . @entity129 has been also described. The aim of this study was to evaluate MR angiography and MR findings in a population of @entity1 with @entity4066 . MATERIALS AND METHODS: We reviewed the MR angiography and MR exams of 15 @entity1 (10 males, 5 females, average age 42.0, age range 30-55) with carotid and/or @entity4066 ; the serial MR follow-up studies were also examined. RESULTS: Twelve internal carotid arteries (ICA) showed the presence of an @entity850 ; three of these showed complete occlusion. In two @entity1 both ICA were involved. Six vertebral arteries (VA) showed @entity850 (only one @entity1 suffered from both CI and VA dissection); in one case there was also a @entity2849 of the VA. Follow-up studies showed vessel lumen re-opening in 5/11 ICA (one @entity1 underwent vascular stent positioning) and in 3/6 VA. CONCLUSIONS: The present study confirms the usefulness of MR angiography and MR in the diagnosis and follow-up of @entity1 with @entity4066 .

title: Carotid and XXXX : Magnetic Resonance findings in 15 cases.

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['Cranial nerve palsy']

entities_list: @entity4066 :: ('MESH:D020217', 'Disease') :: ['carotid and vertebral artery dissections', 'carotid and vertebral artery dissection', 'vertebral artery dissection']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['irregular stenosis']

entities_list: @entity1614 :: ('MESH:D008382', 'Disease') :: ["Marfan's syndrome"]

entities_list: @entity4267 :: ('MESH:D005352', 'Disease') :: ['fibromuscular dysplasia']

entities_list: @entity4243 :: ('MESH:D004535', 'Disease') :: ['Ehlers-Danlos syndrome']

entities_list: @entity12977 :: ('MESH:D011561', 'Disease') :: ['pseudoxanthoma elasticum']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['facial pain']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['diffuse headache']

entities_list: @entity6926 :: ('MESH:D010013', 'Disease') :: ['osteogenesis imperfecta']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm']

answer: @entity4066 :: (MESH:D020217,Disease) :: ['vertebral artery dissection']


abstract: BACKGROUND: Prompt recognition of invasive @entity57 ( @entity9348 ) after heart transplantation is essential for achieving a successful outcome. However, the significance of the isolation of from respiratory specimens in heart transplant recipients is not established. METHODS: From 1990 to 1999, we analyzed first respiratory specimens with spp. growth from heart transplant @entity1 in our institution. All specimens were cultured in both fungal and conventional media. Diagnosis of proven and probable @entity9348 or colonization was made according to criteria of the Mycoses Study Group. RESULTS: During the 10-year study period, spp. was recovered from 30 episodes from 27 heart transplant recipients (incidence: 10.5%). Three episodes were classified as indeterminate and were included in the analysis in a double way, first considering them as true positives and afterward as true negatives, so ranges were obtained. After applying diagnostic criteria, 18 of 30 episodes were proven or probable @entity9348 , and 9 episodes were colonizations. Accordingly, 7 to 8% of heart transplant recipients suffered an @entity9348 , and the overall positive predictive value ( @entity2286 ) was 60% to 70%. When analyzed by species, the @entity2286 of recovering was 78% to 91%, whereas it was 0% for other species. The @entity2286 increased to 88% to 100% when was recovered from a respiratory specimen other than sputum and decreased to 50% to 67% when it was recovered from sputum. The sensitivities of fungal and conventional media for the recovery of spp. were 95% to 100% and 33% to 38%, respectively. CONCLUSION: The isolation of from the respiratory tract of a heart transplant recipient is highly predictive of @entity3 .

title: The isolation of Aspergillus fumigatus from respiratory tract specimens in heart transplant recipients is highly predictive of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity57 :: ('MESH:D055732', 'Disease') :: ['pulmonary aspergillosis']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive aspergillosis']

answer: @entity3 :: (MESH:D009362,Disease) :: ['invasive aspergillosis']


abstract: OBJECTIVES: To test the validity of the comparative audit tool of POSSUM (Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity) against a cohort of 92 consecutive laryngectomies at a major tertiary referral centre for @entity135 . The major outcome measurements were 30-day mortality rates, formation of a pharyngo-cutaneous @entity292 , and length of hospital stay. METHODS: By means of a prospective and retrospective case note analysis. RESULTS: No significant difference between the mean POSSUM morbidity scores of those @entity1 who did, or did not develop a @entity292 , was found (p=0.535, 95% C.I. -4.36 to 8.33). No significant correlation was observed between POSSUM predicted morbidity and bed occupancy [r=0.137 (95% C.I. -0.070 to 0.334)]. The Portsmouth POSSUM equation for mortality however did accurately predict the mortality rate (observed to expected ratio of 1.05). CONCLUSION: The authors propose that whilst there are many similar factors linked to mortality between cohorts of general surgical and head and neck @entity1 , there are several highly specific risk factors in open surgery of the upper aero-digestive tract in the head and neck which are linked with wound breakdown and morbidity which are omitted from the POSSUM scoring system. The authors warn against the use of this comparative audit tool in its current state for such surgical procedures and recommend the creation of a specific POSSUM for @entity135 surgery.

title: Is POSSUM predictive of morbidity and mortality in laryngectomy XXXX ?

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Damage to the airway epithelium is one prominent feature of the damage seen in chronic @entity565 . Cortico- @entity230 induce apoptosis in inflammatory cells, which in part explains their ability to suppress @entity32 . However, corticosteroid therapy does not necessarily reverse the epithelial damage seen in asthmatic airways. OBJECTIVE: We hypothesized that @entity288 might induce airway epithelial cell apoptosis as one potential explanation for this persistent damage. METHODS: BALB/c @entity19 were treated with 1 mg/kg @entity619 by means of intraperitoneal injection for 3 days to 4 weeks. Additional @entity19 were sensitized and challenged with @entity10328 and then followed for 14 days with or without @entity619 treatment starting on day 4 after challenge. Apoptosis was measured by using terminal deoxynucleotidyl transferase-mediated @entity9342 nick end labeling and immunohistochemistry for the @entity14881 cleavage product of @entity12874 polymerase. Shed epithelial cells were counted in bronchoalveolar lavage fluid. RESULTS: In a time-dependent manner @entity619 treatment increased epithelial cell apoptosis and shedding into the airway lumen. This was not associated with any change in the abundance of the apoptotic regulator @entity26667 . In animals sensitized and challenged with @entity10328 , treatment with 1 mg/kg @entity619 starting 4 days after challenge reversed the inflammatory changes but did not reverse either epithelial cell shedding or apoptosis seen after allergen challenge. CONCLUSION: Corticosteroids might induce apoptotic cell death of airway epithelium in vivo and fail to mitigate epithelial cell shedding and apoptosis elicited by means of allergen challenge. This raises the possibility that at least one of the major components of chronic airway damage in @entity565 , epithelial shedding, might in part result from a major therapy used for disease control.

title: Corticosteroid-induced apoptosis in @entity19 airway epithelium: effect in normal airways and after allergen-induced XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['airway inflammation']

entities_list: @entity12874 :: ('MESH:D011064', 'Chemical') :: ['poly (adenosine diphosphate-ribose)']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity9342 :: ('MESH:C027078', 'Chemical') :: ['deoxyuridine triphosphate']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity32 :: (MESH:D007249,Disease) :: ['airway inflammation']


abstract: BACKGROUND: Damage to the airway epithelium is one prominent feature of the damage seen in chronic @entity565 . Cortico- @entity230 induce apoptosis in inflammatory cells, which in part explains their ability to suppress @entity32 . However, corticosteroid therapy does not necessarily reverse the epithelial damage seen in asthmatic airways. OBJECTIVE: We hypothesized that @entity288 might induce airway epithelial cell apoptosis as one potential explanation for this persistent damage. METHODS: BALB/c @entity19 were treated with 1 mg/kg @entity619 by means of intraperitoneal injection for 3 days to 4 weeks. Additional @entity19 were sensitized and challenged with @entity10328 and then followed for 14 days with or without @entity619 treatment starting on day 4 after challenge. Apoptosis was measured by using terminal deoxynucleotidyl transferase-mediated @entity9342 nick end labeling and immunohistochemistry for the @entity14881 cleavage product of @entity12874 polymerase. Shed epithelial cells were counted in bronchoalveolar lavage fluid. RESULTS: In a time-dependent manner @entity619 treatment increased epithelial cell apoptosis and shedding into the airway lumen. This was not associated with any change in the abundance of the apoptotic regulator @entity26667 . In animals sensitized and challenged with @entity10328 , treatment with 1 mg/kg @entity619 starting 4 days after challenge reversed the inflammatory changes but did not reverse either epithelial cell shedding or apoptosis seen after allergen challenge. CONCLUSION: Corticosteroids might induce apoptotic cell death of airway epithelium in vivo and fail to mitigate epithelial cell shedding and apoptosis elicited by means of allergen challenge. This raises the possibility that at least one of the major components of chronic airway damage in @entity565 , epithelial shedding, might in part result from a major therapy used for disease control.

title: Corticosteroid-induced apoptosis in XXXX airway epithelium: effect in normal airways and after allergen-induced @entity32 .

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: @entity1457 ( @entity1457 ) are the most abundant heat stress-induced proteins in plants. In @entity579 , there are at least seven members of class-I @entity1457 . A 1.6-kb DNA fragment was isolated from the EcoRI-digested @entity579 genomic library probed with the cDNA pTS1 encoding a 16.9-kDa class-I @entity1457 . This fragment was composed of 365-bp tandem direct repeats (DRs) and 441-bp near perfect long terminal inverted repeats (LTIRs). The DRs contain 123-bp regions with 99% @entity377 identity to the 5' coding region of the Oshsp16.9B gene. Two putative pseudogenes were deduced from the DRs. Using the LTIR as a specific probe, Southern-blotting analysis showed that there was a single copy of this 1.6-kb DNA fragment in the @entity579 genome. By genomic walking, we located this fragment in proximity 5'-upstream of the Oshsp16.9B gene that was mapped on chromosome 1 with other two class-I @entity1457 genes, Oshsp16.9A and Oshsp16.9C. By comparative analysis of the @entity377 sequences of class-I @entity1457 genes clustered on chromosome 1 between Tainung No. 67 and Nipponbare cultivars, we confirmed our mapping results of these genes and only the promoter region of Oshsp16.9B was different. However, we found that the expression profile of Oshsp16.9B upon different heat stresses in Nipponbare was not significantly different relative to that in Tainung No. 67.

title: Characterization of a unique genomic clone located 5' upstream of the Oshsp16.9B gene on chromosome 1 in XXXX ( @entity579 . cv Tainung No. 67).

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['sHSP', 'Small heat-shock proteins']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

answer: @entity579 :: (4530,Species) :: ['rice']


abstract: @entity1457 ( @entity1457 ) are the most abundant heat stress-induced proteins in plants. In @entity579 , there are at least seven members of class-I @entity1457 . A 1.6-kb DNA fragment was isolated from the EcoRI-digested @entity579 genomic library probed with the cDNA pTS1 encoding a 16.9-kDa class-I @entity1457 . This fragment was composed of 365-bp tandem direct repeats (DRs) and 441-bp near perfect long terminal inverted repeats (LTIRs). The DRs contain 123-bp regions with 99% @entity377 identity to the 5' coding region of the Oshsp16.9B gene. Two putative pseudogenes were deduced from the DRs. Using the LTIR as a specific probe, Southern-blotting analysis showed that there was a single copy of this 1.6-kb DNA fragment in the @entity579 genome. By genomic walking, we located this fragment in proximity 5'-upstream of the Oshsp16.9B gene that was mapped on chromosome 1 with other two class-I @entity1457 genes, Oshsp16.9A and Oshsp16.9C. By comparative analysis of the @entity377 sequences of class-I @entity1457 genes clustered on chromosome 1 between Tainung No. 67 and Nipponbare cultivars, we confirmed our mapping results of these genes and only the promoter region of Oshsp16.9B was different. However, we found that the expression profile of Oshsp16.9B upon different heat stresses in Nipponbare was not significantly different relative to that in Tainung No. 67.

title: Characterization of a unique genomic clone located 5' upstream of the Oshsp16.9B gene on chromosome 1 in @entity579 ( XXXX . cv Tainung No. 67).

answer: @entity579 :: (4530,Species) :: ['Oryza sativa L']


abstract: BACKGROUND: The application of a single allergen specific IgE (sIgE) cut point, such as 0.35 kU/L, to determine sensitization for all allergens may be suboptimal. OBJECTIVES: To analyze self-reported symptoms suggestive of @entity235 and cat @entity566 in relation to the test performance characteristics of low level, but reliably detectable, sIgE and to compare these cut points to the traditional 0.35-kU/L cut point. METHODS: Interviews and blood samples were collected among 564 young adult @entity1 of a general risk birth cohort. Data collected from the @entity1 ' parents were analyzed as validation populations. A history of symptoms consistent with @entity566 on exposure to pets was obtained by standardized questionnaire. Allergen sIgE levels for @entity235 and cat were evaluated with Pharmacia @entity9527 . Receiver operating characteristic curves were constructed and the performance characteristics of the traditional sIgE cut point of 0.35 kU/L were compared with cut points as low as 0.1 kU/L. RESULTS: Using the Youden J criteria, based on the highest sum of sensitivity and specificity for a diagnostic test, cut points of 0.12 kU/L for cat and 0.2 kU/L for @entity235 were identified as performing optimally among the @entity1 population. In 2 validation populations, consisting of the @entity1 ' mothers and fathers, the performance of these alternative cut points were superior or similar to the traditional 0.35-kU/L sIgE level. CONCLUSIONS: Accurately measured sIgE at levels approaching the lower limit of detection of current assays may be useful in confirming sensitization. Optimal clinical application of these tests will continue to require careful integration of the result and the strength of the @entity1 's history.

title: Analysis of allergen specific IgE cut points to cat and XXXX in the Childhood Allergy Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'patient']

answer: @entity235 :: (9615,Species) :: ['dog']


abstract: OBJECTIVES: To report 3 cases @entity19417 ( @entity19417 ) that developed in @entity1 suffering from @entity785 ( @entity785 ) and to review previously reported cases. METHODS: We describe 3 @entity1 diagnosed with @entity785 who developed severe @entity19417 that presented as @entity11278 . A retrospective review of the literature was performed using the PubMed database. RESULTS: The first @entity1 presented with rapidly progressive @entity177 and then with 2 episodes of @entity548 . She was partially refractory to treatment with @entity288 and @entity786 but responded promptly to treatment with rituximab. The second @entity1 suffered from 2 episodes of @entity548 ; the first responded to intravenous @entity288 , but the second was fatal despite aggressive immune suppression with @entity288 and @entity786 . The third @entity1 presented with a clinical picture compatible with @entity8 ( @entity8 ) but was later diagnosed with crescentic GN and subsequently died from probable @entity548 . Thirty-seven cases of @entity19417 in @entity785 @entity1 have been described in the English literature. Clinical manifestations include rapidly progressive GN, @entity548 , @entity63 , and @entity1910 . In contrast to @entity8 that usually develops early in the course of @entity785 , ANCA-associated GN in @entity785 @entity1 occurred later, after several years of illness. @entity101 , @entity2106 , and @entity882 that are the hallmark of @entity8 were observed only in a minority of @entity19417 cases. Almost all cases of @entity19417 in @entity785 were positive for MPO-ANCA. CONCLUSIONS: @entity19417 in the setting of @entity785 is a diagnostic challenge. Differential diagnosis from @entity8 is crucial as treatment approach for these conditions completely differs. High doses of @entity288 and immune suppression are advocated in severe @entity19417 . In resistant cases, treatment with rituximab may be considered.

title: Anti-neutrophil antibody associated vasculitis in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['SRC', 'scleroderma renal crisis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['massive alveolar hemorrhage', 'alveolar hemorrhage', 'fulminant alveolar hemorrhage']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['limb ischemia']

entities_list: @entity1910 :: ('MESH:D005076', 'Disease') :: ['vasculitic skin rash']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity11278 :: ('MESH:C538458', 'Disease') :: ['crescentic glomerulonephritis (GN) and/or alveolar hemorrhage']

entities_list: @entity2106 :: ('MESH:D011697', 'Disease') :: ['microangiopathic hemolytic anemia']

entities_list: @entity19417 :: ('MESH:D056648', 'Disease') :: ['AAV', 'ANCA-associated vasculitis']

entities_list: @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic sclerosis', 'SSc']

answer: @entity785 :: (MESH:D012595,Disease) :: ['systemic sclerosis']


abstract: OBJECTIVE: To report the magnetic resonance (MR) imaging findings of enlarged veins in the spinoglenoid notch as a cause of @entity2850 . DESIGN AND @entity1 : Six @entity1 presented to MR imaging for evaluation of chronic @entity158 . Clinical information and MR imaging studies were reviewed. The spinoglenoid notch vascular structures were compared with measurements made in 10 age-matched controls. RESULTS: Spinoglenoid notch vascular structures measured in 10 asymptomatic age-matched control @entity1 ranged from 1 to 4 mm in diameter with an average of 2.2 mm. The six study @entity1 had vascular structures that ranged from 6 to 10 mm in diameter with an average of 8.4 mm. @entity194 and @entity1560 of the infraspinatus muscle was noted as an associated finding at MR imaging in all six @entity1 . Surgery was performed in three of the six @entity1 , at which time a venous varix was identified in the spinoglenoid notch in all three @entity1 . CONCLUSION: We describe distended veins in the spinoglenoid notch. These may be readily apparent at MR imaging and should be distinguished from @entity2850 in the absence of labral tears, especially if percutaneous aspiration of a ganglion cyst is entertained.

title: Enlarged spinoglenoid notch veins causing XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty infiltration']

entities_list: @entity2850 :: ('MESH:D009408', 'Disease') :: ['paralabral ganglion cysts compressing the suprascapular nerve', 'suprascapular nerve compression']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['shoulder pain']

answer: @entity2850 :: (MESH:D009408,Disease) :: ['suprascapular nerve compression']


abstract: The impact of @entity209 ( @entity2246 ) and @entity4903 in pediatrics has markedly increased during the last few decades. Critical periods in the development of the central nervous system need special attention in @entity1 with these disorders. Early diagnosis and treatment are important in order to prevent @entity1032 and serious handicaps in some of these @entity1 . Certain @entity1 with @entity209 lack early clinical symptoms or have so non-specific signs that permanent @entity16 are present when the @entity1 are finally diagnosed. One way to identify these @entity1 is by means of mass screening. A blood sample is then collected from every newborn @entity1 and analyzed for abnormal levels of metabolites or hormones. It is possible to detect at least thirty different disorders in this way. In most European countries screening programmes involve @entity814 ( @entity814 ) and @entity6750 . The prognosis for these @entity1 has improved dramatically after the introduction of screening. The Swedish neonatal metabolic screening programme was started in 1965 by screening for @entity814 . Subsequently, screening for @entity1624 and @entity6750 was added. The result of the screening programme 1965-1985 is as follows: (table; see text) The main benefit of early detection and treatment of @entity1 with @entity814 , @entity6750 and @entity1624 is the prevention of @entity1032 and other handicaps. Recently nationwide pilot screening for @entity774 ( @entity25248 ) was started.

title: Neonatal screening for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infant']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation']

entities_list: @entity25248 :: ('MESH:D047808', 'Disease') :: ['adrenogenital syndrome']

entities_list: @entity6750 :: ('MESH:D003409', 'Disease') :: ['congenital hypothyroidism']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological handicaps']

entities_list: @entity814 :: ('MESH:D010661', 'Disease') :: ['PKU', 'phenylketonuria']

entities_list: @entity774 :: ('MESH:D000312', 'Disease') :: ['congenital adrenal hyperplasia']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic diseases', 'metabolic and endocrine disorders']

entities_list: @entity1624 :: ('MESH:D005693', 'Disease') :: ['galactosemia']

entities_list: @entity4903 :: ('MESH:D004700', 'Disease') :: ['endocrine disorders']

entities_list: @entity2246 :: ('MESH:D008661', 'Disease') :: ['inborn errors of metabolism']

answer: @entity209 :: (MESH:D008659,Disease) :: ['metabolic and endocrine disorders']


abstract: BACKGROUND AND AIMS: The Barcelona Clinic @entity96 (BCLC) staging system is the algorithm most widely used to manage @entity1 with @entity157 ( @entity157 ). We aimed to investigate the extent to which the BCLC recommendations effectively guide clinical practice and assess the reasons for any deviation from the recommendations. MATERIAL AND METHODS: The first-line treatments assigned to @entity1 included in the prospective Bern @entity157 cohort were analyzed. RESULTS: Among 223 @entity1 included in the cohort, 116 were not treated according to the BCLC algorithm. Eighty percent of the @entity1 in BCLC stage 0 (very early @entity157 ) and 60% of the @entity1 in BCLC stage A (early @entity157 ) received recommended curative treatment. Only 29% of the BCLC stage B @entity1 (intermediate @entity157 ) and 33% of the BCLC stage C @entity1 (advanced @entity157 ) were treated according to the algorithm. Eighty-nine percent of the BCLC stage D @entity1 (terminal @entity157 ) were treated with best supportive care, as recommended. In 98 @entity1 (44%) the performance status was disregarded in the stage assignment. CONCLUSION: The management of @entity157 in clinical practice frequently deviates from the BCLC recommendations. Most of the curative therapy options, which have well-defined selection criteria, were allocated according to the recommendations, while the majority of the palliative therapy options were assigned to @entity1 with @entity5 stages not aligned with the recommendations. The only parameter which is subjective in the algorithm, the performance status, is also the least respected.

title: Treatment allocation in XXXX : Assessment of the BCLC algorithm.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['Liver Cancer']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: PURPOSE: To evaluate the effectiveness of acellular @entity291 pericardium grafts (Normal GEN  ) used as scaffolds for conjunctival reconstruction. METHOD: The acellular @entity291 pericardium graft and the amnion graft were implanted into the bulbar conjunctival defects of adult @entity95 . Conjunctival samples of implanted materials and @entity154 controls were observed at day 3, 7, 14, 21, 28, and 56 postoperatively. Histological examination was observed at day 14, 28, and 56 of surgery, including @entity1710 - @entity1711 staining, periodic acid-Schiff staining, and Masson's trichrome staining, while immunofluorescent microscopy was observed at 14  days and 28  days after surgery. Results were compared among the Normal GEN  , amnion, and @entity154 controls. RESULTS: All three groups showed complete conjunctival reconstruction. Wounds that were not grafted closed by formation of conjunctival scar characterized by a linear array of densely packed collagen fibers in Tenon's capsule. Subepithelial tissue in the grafted groups comprised a loosely organized network of randomly oriented collagen that resembled that of the normal bulbar conjunctiva. However, there was a dense layer of aligned collagen between the conjunctival Tenon's capsule and the sclera in the NormalGEN   group, about 250   m in thickness. CONCLUSIONS: Implantation of the NormalGEN   graft promoted the formation of conjunctiva as a kind of scaffold both in structure and in function. It had more advantageous mechanical properties than the amnion, strong and elastic, during the period of conjunctival reconstruction.

title: Conjunctival structural and functional reconstruction using acellular XXXX pericardium graft (Normal GEN  ) in @entity95 .

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['blank defect']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: PURPOSE: To evaluate the effectiveness of acellular @entity291 pericardium grafts (Normal GEN  ) used as scaffolds for conjunctival reconstruction. METHOD: The acellular @entity291 pericardium graft and the amnion graft were implanted into the bulbar conjunctival defects of adult @entity95 . Conjunctival samples of implanted materials and @entity154 controls were observed at day 3, 7, 14, 21, 28, and 56 postoperatively. Histological examination was observed at day 14, 28, and 56 of surgery, including @entity1710 - @entity1711 staining, periodic acid-Schiff staining, and Masson's trichrome staining, while immunofluorescent microscopy was observed at 14  days and 28  days after surgery. Results were compared among the Normal GEN  , amnion, and @entity154 controls. RESULTS: All three groups showed complete conjunctival reconstruction. Wounds that were not grafted closed by formation of conjunctival scar characterized by a linear array of densely packed collagen fibers in Tenon's capsule. Subepithelial tissue in the grafted groups comprised a loosely organized network of randomly oriented collagen that resembled that of the normal bulbar conjunctiva. However, there was a dense layer of aligned collagen between the conjunctival Tenon's capsule and the sclera in the NormalGEN   group, about 250   m in thickness. CONCLUSIONS: Implantation of the NormalGEN   graft promoted the formation of conjunctiva as a kind of scaffold both in structure and in function. It had more advantageous mechanical properties than the amnion, strong and elastic, during the period of conjunctival reconstruction.

title: Conjunctival structural and functional reconstruction using acellular @entity291 pericardium graft (Normal GEN  ) in XXXX .

answer: @entity95 :: (9986,Species) :: ['rabbits']


abstract: OBJECTIVE: To determine if the characteristics of @entity1 with @entity1478 changed as minimally invasive modalities for diagnosis and surgical treatment were integrated to our clinical practice. MATERIALS AND METHODS: The pathologic reports of all @entity1 diagnosed with @entity1478 in 1990 (220 @entity1 ) and 1996 (386 @entity1 ) were reviewed. The respective medical records were reviewed for anthropomorphic factors, bleeding pattern, diagnosis, and modality of surgical removal. Comparisons of dichotomous data and analysis of nominal variables with two or more categories were carried out with the chi(2) test. RESULTS: Differences in @entity1 characteristics or pattern of bleeding were minimal. In both groups, @entity1478 were more frequent in @entity1 with @entity548 , reaching almost 80%. Diagnostic and therapeutic modalities were significantly different in 1990 vs. 1996. Diagnosis by ultrasound increased fivefold (3.6 vs. 16.8%) and operative hysteroscopy increased threefold (6.4 vs. 19.7). The frequency of incidental diagnosis of @entity1478 at the time of hysterectomy decreased significantly. The most frequent modality of surgery done in 1990 was dilatation and curettage (44.6%), followed in frequency by endometrial biopsy and abdominal hysterectomy. In contrast, the most frequent modality in 1996 was hysteroscopic resection (36.8%), followed by dilatation and curettage (12.8%). CONCLUSIONS: The introduction of minimally invasive methods of diagnosis and treatment of @entity1478 has not changed the overall @entity1 population with this lesion.

title: Does the introduction of new technology change population demographics? Minimally invasive technologies and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial polyps']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['abnormal bleeding']

answer: @entity1478 :: (MESH:D014591,Disease) :: ['endometrial polyps']


abstract: @entity263 is a slowly developing but very common @entity5 in males that may be amenable to preventive strategies that are not toxic. Chinese red @entity375 @entity579 (RYR), a food herb made by fermenting Monascus purpureus Went @entity375 on white @entity579 , contains a mixture of eight different monacolins that inhibit cholesterogenesis in addition to red pigments with antioxidant properties. Monacolin K is identical to lovastatin (LV), but LV unlike RYR can be used in individuals intolerant to statins due to @entity925 . Both LV and RYR inhibit de novo cholesterogenesis, which is critical to the growth of @entity5 cells. Long-term use of statin drugs has been associated with a reduced risk of @entity263 . We have previously shown that RYR inhibited @entity342 -dependent and @entity342 receptor-overexpressing @entity342 -independent @entity263 cell proliferation in vitro. This study was designed to determine whether RYR and @entity263 growth in @entity915 @entity19 . RYR significantly reduced @entity5 volumes of @entity342 -dependent and @entity342 -independent prostate xenograft @entity5 compared with animals receiving vehicle alone (P < 0.05). Inhibition by RYR was greater than that observed with LV at the dose found in RYR, showing that other compounds in RYR contributed to the antiproliferative effect. There was a significant correlation of @entity5 volume to serum @entity165 (P < 0.001). RYR decreased gene expression of @entity342 synthesizing enzymes (HSD3B2, AKR1C3, and SRD5A1) in both type of @entity5 (P < 0.05). Clinical studies of RYR for @entity263 prevention in the increasing population of @entity1 undergoing active surveillance should be considered.

title: Chinese red XXXX @entity579 @entity263 growth in @entity915 @entity19 .

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['LV inhibit prostate tumor', 'Prostate cancer', 'prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle pain']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity375 :: (4932,Species) :: ['yeast']


abstract: @entity263 is a slowly developing but very common @entity5 in males that may be amenable to preventive strategies that are not toxic. Chinese red @entity375 @entity579 (RYR), a food herb made by fermenting Monascus purpureus Went @entity375 on white @entity579 , contains a mixture of eight different monacolins that inhibit cholesterogenesis in addition to red pigments with antioxidant properties. Monacolin K is identical to lovastatin (LV), but LV unlike RYR can be used in individuals intolerant to statins due to @entity925 . Both LV and RYR inhibit de novo cholesterogenesis, which is critical to the growth of @entity5 cells. Long-term use of statin drugs has been associated with a reduced risk of @entity263 . We have previously shown that RYR inhibited @entity342 -dependent and @entity342 receptor-overexpressing @entity342 -independent @entity263 cell proliferation in vitro. This study was designed to determine whether RYR and @entity263 growth in @entity915 @entity19 . RYR significantly reduced @entity5 volumes of @entity342 -dependent and @entity342 -independent prostate xenograft @entity5 compared with animals receiving vehicle alone (P < 0.05). Inhibition by RYR was greater than that observed with LV at the dose found in RYR, showing that other compounds in RYR contributed to the antiproliferative effect. There was a significant correlation of @entity5 volume to serum @entity165 (P < 0.001). RYR decreased gene expression of @entity342 synthesizing enzymes (HSD3B2, AKR1C3, and SRD5A1) in both type of @entity5 (P < 0.05). Clinical studies of RYR for @entity263 prevention in the increasing population of @entity1 undergoing active surveillance should be considered.

title: Chinese red @entity375 XXXX @entity263 growth in @entity915 @entity19 .

answer: @entity579 :: (4530,Species) :: ['rice']