abstract: @entity1358 is the most frequent type of @entity703 . Recently, attention has been focused in the expression of angiogenic factors by these @entity5 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity1 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity1358 were studied. Clinical and pathological data were collected. @entity5 were studied to assess immunohistochemical expression of the following markers: @entity7 , @entity7738 , @entity2280 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7738 was directly related to Furhman grade, invasion of the renal vein and @entity5 stage. Likewise, @entity5 proliferation index, assessed with Ki67, was directly related to the presence of @entity39 , capsular invasion and advanced @entity5 stage. Regarding the expression of @entity2280 , vascular density was inversely related to @entity5 @entity39 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity5 evolution and prognostic evaluation of these @entity5 .

title: Expression of @entity7 , @entity7738 , @entity2280 and Ki67 in XXXX and their relationship with conventional prognostic markers.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['Clear cell renal carcinoma', 'clear cell renal cell carcinoma']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal carcinoma']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['clear cell renal cell carcinomas']


abstract: @entity1358 is the most frequent type of @entity703 . Recently, attention has been focused in the expression of angiogenic factors by these @entity5 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity1 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity1358 were studied. Clinical and pathological data were collected. @entity5 were studied to assess immunohistochemical expression of the following markers: @entity7 , @entity7738 , @entity2280 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7738 was directly related to Furhman grade, invasion of the renal vein and @entity5 stage. Likewise, @entity5 proliferation index, assessed with Ki67, was directly related to the presence of @entity39 , capsular invasion and advanced @entity5 stage. Regarding the expression of @entity2280 , vascular density was inversely related to @entity5 @entity39 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity5 evolution and prognostic evaluation of these @entity5 .

title: Expression of XXXX , @entity7738 , @entity2280 and Ki67 in @entity1358 and their relationship with conventional prognostic markers.

answer: @entity7 :: (7422,Gene) :: ['VEGF-A']


abstract: @entity1358 is the most frequent type of @entity703 . Recently, attention has been focused in the expression of angiogenic factors by these @entity5 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity1 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity1358 were studied. Clinical and pathological data were collected. @entity5 were studied to assess immunohistochemical expression of the following markers: @entity7 , @entity7738 , @entity2280 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7738 was directly related to Furhman grade, invasion of the renal vein and @entity5 stage. Likewise, @entity5 proliferation index, assessed with Ki67, was directly related to the presence of @entity39 , capsular invasion and advanced @entity5 stage. Regarding the expression of @entity2280 , vascular density was inversely related to @entity5 @entity39 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity5 evolution and prognostic evaluation of these @entity5 .

title: Expression of @entity7 , @entity7738 , XXXX and Ki67 in @entity1358 and their relationship with conventional prognostic markers.

answer: @entity2280 :: (947,Gene) :: ['CD34']


abstract: @entity1358 is the most frequent type of @entity703 . Recently, attention has been focused in the expression of angiogenic factors by these @entity5 , which would justify in part their capacity to grow, invade and disseminate, stating a worse evolution of those @entity1 with an unfavorable angiogenic profile. 83 samples of nephrectomy with a diagnosis of @entity1358 were studied. Clinical and pathological data were collected. @entity5 were studied to assess immunohistochemical expression of the following markers: @entity7 , @entity7738 , @entity2280 and Ki67. Results indicated a direct linear relationship between expressions of these four markers. Besides, the expression of @entity7738 was directly related to Furhman grade, invasion of the renal vein and @entity5 stage. Likewise, @entity5 proliferation index, assessed with Ki67, was directly related to the presence of @entity39 , capsular invasion and advanced @entity5 stage. Regarding the expression of @entity2280 , vascular density was inversely related to @entity5 @entity39 and overall survival. These findings are controversial compared with the available literature. Then, a research scenery would be open, where the importance of generating prospective and more standardized studies are highlighted to determine the role of these angiogenic factors in @entity5 evolution and prognostic evaluation of these @entity5 .

title: Expression of @entity7 , XXXX , @entity2280 and Ki67 in @entity1358 and their relationship with conventional prognostic markers.

answer: @entity7738 :: (3091,Gene) :: ['HIF-1 A']


abstract: BACKGROUND: Pulsed dye laser (PDL) treatments have been suggested to be a safe and effective therapeutic approach for treating @entity1491 ( @entity1491 ). However, robust supporting evidence is lacking due to inconsistent design of available studies. OBJECTIVES: To evaluate PDL efficacy and safety in treating superficial BCC (sBCC) at low-risk anatomical sites in an evidence-based study setting. MATERIALS AND METHODS: Thirty-nine @entity1 (27 @entity1 and 12 @entity1 , 75  9      10  years) with a total of 100 sBCCs were randomized to receive PDL treatment (wavelength 595  nm; fluence 8  J  cm(-2) ; pulse duration 0  5  ms; spot size 10  mm) or sham treatment. The primary endpoint was complete clinical and histological remission of the @entity5 at 6-month follow-up; the secondary endpoints were the evaluation of side-effects and @entity158 as well as @entity1 satisfaction. RESULTS: The primary endpoint showed significant superiority of the laser group to the sham group (P  <  0  0001). Complete remission was achieved in 44 of 56 cases (78  6%) in the laser and in two of 44 cases (4  5%) in the sham treatment arm. The main adverse events in the laser group were crusts, @entity4182 . An average of 72% of @entity1 stated at the individual sessions that they were 'satisfied' with the laser treatment, whereas 25% were 'very satisfied'. CONCLUSIONS: PDL is an effective and safe method for treating sBCC. However, the occurrence of persistent dyspigmentation still limits the potential for excellent cosmetic outcomes.

title: The role of the 595-nm pulsed dye laser in treating XXXX : outcome of a double-blind randomized placebo-controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity4182 :: ('MESH:D017496', 'Disease') :: ['hyper- and hypopigmentation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinomas', 'BCCs']

answer: @entity1491 :: (MESH:D002280,Disease) :: ['superficial basal cell carcinoma']


abstract: Clinically evident @entity370 involving the heart has been noted in at least 2 to 7% of @entity1 with @entity370 , but occult involvement is much higher (> 20%). @entity299 is often not recognized antemortem, as @entity944 may be the presenting feature. Cardiac involvement may occur at any point during the course of @entity370 and may occur in the absence of pulmonary or systemic involvement. @entity370 can involve any part of the heart, with protean manifestations. Prognosis of @entity299 is related to extent and site(s) of involvement. Most deaths due to @entity299 are due to @entity943 or @entity8526 , but granulomatous infiltration of the myocardium may be lethal. The definitive diagnosis of isolated @entity299 is difficult. The yield of endomyocardial biopsies is low; treatment of @entity299 is often warranted even in the absence of histologic proof. Radionuclide scans are integral to the diagnosis. Currently, @entity419 positron emission tomography/computed tomography and @entity2287 -enhanced magnetic resonance imaging scans are the key imaging modalities to diagnose @entity299 . The prognosis of @entity299 is variable, but mortality rates of untreated @entity299 are high. Although randomized therapeutic trials have not been done, @entity288 (alone or combined with additional immunosuppressive medications) remain the mainstay of treatment. Because of the potential for @entity1164 , implantable cardioverter-defibrillators should be placed in any @entity1 with @entity299 and serious @entity943 or @entity616 , and should be considered for @entity296 . Cardiac transplantation is a viable option for @entity1 with end-stage @entity299 refractory to medical therapy.

title: Cardiac involvement in XXXX : evolving concepts in diagnosis and treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy']

entities_list: @entity419 :: ('MESH:D019788', 'Chemical') :: ['18F-fluorodeoxyglucose']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['Cardiac sarcoidosis', 'cardiac sarcoidosis']

entities_list: @entity8526 :: ('MESH:C562490', 'Disease') :: ['conduction defects']

entities_list: @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis', 'Sarcoidosis']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'arrhythmias']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['heart block']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity370 :: (MESH:D012507,Disease) :: ['sarcoidosis']


abstract: BACKGROUND: Several different methods have been used to assess pulmonary permeability in response to @entity647 ( @entity647 ). However, these methods often involve complicated procedures and algorithms that are difficult to precisely control. The purpose of the current study is to establish a feasible method to evaluate alterations in lung permeability by instilling fluorescently labeled dextran ( @entity2823 -Dextran) intranasally. METHODS/PRINCIPAL FINDINGS: For the @entity19 model of direct @entity647 , lipopolysaccharide (LPS) was administered intranasally. @entity2823 -Dextran was instilled intranasally one hour before the @entity19 were euthanized. Plasma fluorescence intensities from the LPS group were significantly higher than in the control group. To determine the reliability and reproducibility of the procedure, we also measured the lung wet-to-dry weight ratio, the protein concentration of the bronchoalveolar lavage fluid, tight and adherens junction markers and pathological changes. Consistent results were observed when the LPS group was compared with the control group. Simultaneously, we found that the concentration of plasma @entity2823 -Dextran was LPS dose-dependent. The concentration of plasma @entity2823 -Dextran also increased with initial intranasal @entity2823 -Dextran doses. Furthermore, increased fluorescence intensity of plasma @entity2823 -Dextran was found in the intraperitoneally LPS-induced @entity647 model. CONCLUSION/SIGNIFICANCE: In conclusion, the measurement of @entity2823 -Dextran in plasma after intranasal instillation is a simple, reliable, and reproducible method to evaluate lung permeability alterations in vivo. The concentration of @entity2823 -Dextran in the plasma may be useful as a potential peripheral biomarker of @entity647 in experimental clinical studies.

title: Pulmonary permeability assessed by fluorescent-labeled dextran instilled intranasally into @entity19 with LPS-induced XXXX .

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury', 'ALI']

answer: @entity647 :: (MESH:D055371,Disease) :: ['acute lung injury']


abstract: BACKGROUND: Several different methods have been used to assess pulmonary permeability in response to @entity647 ( @entity647 ). However, these methods often involve complicated procedures and algorithms that are difficult to precisely control. The purpose of the current study is to establish a feasible method to evaluate alterations in lung permeability by instilling fluorescently labeled dextran ( @entity2823 -Dextran) intranasally. METHODS/PRINCIPAL FINDINGS: For the @entity19 model of direct @entity647 , lipopolysaccharide (LPS) was administered intranasally. @entity2823 -Dextran was instilled intranasally one hour before the @entity19 were euthanized. Plasma fluorescence intensities from the LPS group were significantly higher than in the control group. To determine the reliability and reproducibility of the procedure, we also measured the lung wet-to-dry weight ratio, the protein concentration of the bronchoalveolar lavage fluid, tight and adherens junction markers and pathological changes. Consistent results were observed when the LPS group was compared with the control group. Simultaneously, we found that the concentration of plasma @entity2823 -Dextran was LPS dose-dependent. The concentration of plasma @entity2823 -Dextran also increased with initial intranasal @entity2823 -Dextran doses. Furthermore, increased fluorescence intensity of plasma @entity2823 -Dextran was found in the intraperitoneally LPS-induced @entity647 model. CONCLUSION/SIGNIFICANCE: In conclusion, the measurement of @entity2823 -Dextran in plasma after intranasal instillation is a simple, reliable, and reproducible method to evaluate lung permeability alterations in vivo. The concentration of @entity2823 -Dextran in the plasma may be useful as a potential peripheral biomarker of @entity647 in experimental clinical studies.

title: Pulmonary permeability assessed by fluorescent-labeled dextran instilled intranasally into XXXX with LPS-induced @entity647 .

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: Treatment of @entity1751 has been studied, but treatment strategies and outcomes have not been reported for a large community-based group of @entity1 . OBJECTIVE: We sought to determine the treatments most commonly prescribed and the performance of all systemic and surgical treatments used in @entity1751 @entity1 in Olmsted County, Minnesota, treated over a 40-year period. METHODS: A retrospective chart review was performed to evaluate @entity1751 treatments in 376 episodes with 115 Olmsted County @entity1 seen by a clinician at Mayo Clinic in Rochester, Minnesota, between 1968 and 2008. Treatment episode outcomes were recorded from clinical notes for the 73 treatment episodes that had a follow-up period of more than 30 days. RESULTS: Systemic antibiotics alone were prescribed most frequently in 70.0% of episodes. Systemic antibiotics alone improved 39 of 49 treatment episodes (79.6%), including 13 episodes (26.5%) when the disease was fully cleared. All 5 of 5 episodes (100%) of surgical treatment alone improved, including 4 (80%) in which the disease was fully cleared. Surgery in combination with systemic antibiotic treatment yielded improvement in 5 episodes (71.4%), with 2 episodes (28.6%) showing complete clearance. CONCLUSION: Systemic antibiotics were the most frequently prescribed treatment type in 115 @entity1 over a 40-year period. Both systemic antibiotic therapy and surgical treatment are effective in disease management.

title: Treatment experience in a local population with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1751 :: ('MESH:D017497', 'Disease') :: ['hidradenitis suppurativa']

answer: @entity1751 :: (MESH:D017497,Disease) :: ['hidradenitis suppurativa']


abstract: OBJECTIVES: Seasonal trends were demonstrated in reproduction and sexual activity. Through the secretion ofmelatonin the pineal gland plays an important role in the neuroendocrine control of sexual function and reproductive physiology. We hypothesized that inhibition of the pineal gland activity through a light treatment may favorably affect sexual function. METHODS: We recruited 24 subjects with a diagnosis of @entity458 and/or primary @entity458 . The subjects were randomly assigned to either active light treatment (ALT) or placebo light treatment (L-PBO). @entity1 were assessed during the first evaluation and after 2 weeks of treatment, using the Structured Clinical Interview for Sexual Disorders DSM-IV (SCID-S) and a self-administered rating scale of the level of sexual satisfaction (1 to 10). Repeated ANOVA measures were performed to compare the two groups of @entity1 . Post-hoc analysis was performed by Holm-Sidak test for repeated comparisons. Results. At baseline the two groups were comparable. After 2 weeks the group treated with Light Therapy showed a significant improvement in sexual satisfaction, about 3 times higher than the group that received placebo, while no significant improvement was observed in the group L-PBO. Conclusions. Our results confirm a potentially beneficial effect of Light Therapy on primary @entity250 . In the future, we propose to correlate clinical findings with @entity251 levels pre/post treatment.

title: [Light therapy as a treatment for XXXX --beyond a pilot study].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Participants']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['hypoactive sexual desire disorder', 'sexual arousal disorder']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity250 :: (MESH:D012735,Disease) :: ['sexual dysfunctions']


abstract: Mutations in the @entity51945 gene result in @entity5 , characterized by persistent @entity2265 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity4571 is reported to lower serum @entity1391 by decreasing @entity1372 -dependent @entity1391 co-transporters in the gut and kidney. However, its effectiveness in @entity5 remains unknown. In this study, we investigated @entity4571 as a potential therapy for @entity5 , using a @entity19 model of the disease- @entity51945 knockout @entity19 . Initially, five different doses of @entity4571 were given to normal heterozygous @entity19 intraperitoneally or orally. Treatment had no effect on serum @entity1391 levels, but serum levels of a phosphaturic hormone, @entity51946 ( @entity51946 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity4571 (40mM) was tested in @entity51945 knockout @entity19 fed a high @entity1391 diet. The radiographic data pre- and post-treatment showed that @entity4571 did not reverse the @entity730 . However, the treatment retarded @entity730 growth after 4weeks, while in the untreated animals, @entity730 increased in size. The therapy did not affect serum @entity1391 levels, but intact @entity51946 decreased in the treated @entity19 . The treated @entity19 also had increased @entity460 in the heart. In summary, @entity4571 did not alter serum @entity1391 levels, likely due to compensatory decrease in @entity51946 to counteract the @entity1391 lowering effect of @entity4571 . Although increased @entity460 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity730 .

title: @entity4571 treatment in a @entity19 model of @entity5 reduces serum XXXX and raises heart @entity460 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['familial tumoral calcinosis', 'tumoral calcinosis']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcifications', 'calcification']

entities_list: @entity2265 :: ('MESH:D054559', 'Disease') :: ['hyperphosphatemia']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity4571 :: ('MESH:D009536', 'Chemical') :: ['Nicotinamide', 'nicotinamide']

answer: @entity51946 :: (64654(Tax:10090),Gene) :: ['Fgf23']


abstract: Mutations in the @entity51945 gene result in @entity5 , characterized by persistent @entity2265 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity4571 is reported to lower serum @entity1391 by decreasing @entity1372 -dependent @entity1391 co-transporters in the gut and kidney. However, its effectiveness in @entity5 remains unknown. In this study, we investigated @entity4571 as a potential therapy for @entity5 , using a @entity19 model of the disease- @entity51945 knockout @entity19 . Initially, five different doses of @entity4571 were given to normal heterozygous @entity19 intraperitoneally or orally. Treatment had no effect on serum @entity1391 levels, but serum levels of a phosphaturic hormone, @entity51946 ( @entity51946 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity4571 (40mM) was tested in @entity51945 knockout @entity19 fed a high @entity1391 diet. The radiographic data pre- and post-treatment showed that @entity4571 did not reverse the @entity730 . However, the treatment retarded @entity730 growth after 4weeks, while in the untreated animals, @entity730 increased in size. The therapy did not affect serum @entity1391 levels, but intact @entity51946 decreased in the treated @entity19 . The treated @entity19 also had increased @entity460 in the heart. In summary, @entity4571 did not alter serum @entity1391 levels, likely due to compensatory decrease in @entity51946 to counteract the @entity1391 lowering effect of @entity4571 . Although increased @entity460 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity730 .

title: XXXX treatment in a @entity19 model of @entity5 reduces serum @entity51946 and raises heart @entity460 .

answer: @entity4571 :: (MESH:D009536,Chemical) :: ['Nicotinamide']


abstract: Mutations in the @entity51945 gene result in @entity5 , characterized by persistent @entity2265 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity4571 is reported to lower serum @entity1391 by decreasing @entity1372 -dependent @entity1391 co-transporters in the gut and kidney. However, its effectiveness in @entity5 remains unknown. In this study, we investigated @entity4571 as a potential therapy for @entity5 , using a @entity19 model of the disease- @entity51945 knockout @entity19 . Initially, five different doses of @entity4571 were given to normal heterozygous @entity19 intraperitoneally or orally. Treatment had no effect on serum @entity1391 levels, but serum levels of a phosphaturic hormone, @entity51946 ( @entity51946 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity4571 (40mM) was tested in @entity51945 knockout @entity19 fed a high @entity1391 diet. The radiographic data pre- and post-treatment showed that @entity4571 did not reverse the @entity730 . However, the treatment retarded @entity730 growth after 4weeks, while in the untreated animals, @entity730 increased in size. The therapy did not affect serum @entity1391 levels, but intact @entity51946 decreased in the treated @entity19 . The treated @entity19 also had increased @entity460 in the heart. In summary, @entity4571 did not alter serum @entity1391 levels, likely due to compensatory decrease in @entity51946 to counteract the @entity1391 lowering effect of @entity4571 . Although increased @entity460 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity730 .

title: @entity4571 treatment in a @entity19 model of XXXX reduces serum @entity51946 and raises heart @entity460 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['familial tumoral calcinosis']


abstract: Mutations in the @entity51945 gene result in @entity5 , characterized by persistent @entity2265 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity4571 is reported to lower serum @entity1391 by decreasing @entity1372 -dependent @entity1391 co-transporters in the gut and kidney. However, its effectiveness in @entity5 remains unknown. In this study, we investigated @entity4571 as a potential therapy for @entity5 , using a @entity19 model of the disease- @entity51945 knockout @entity19 . Initially, five different doses of @entity4571 were given to normal heterozygous @entity19 intraperitoneally or orally. Treatment had no effect on serum @entity1391 levels, but serum levels of a phosphaturic hormone, @entity51946 ( @entity51946 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity4571 (40mM) was tested in @entity51945 knockout @entity19 fed a high @entity1391 diet. The radiographic data pre- and post-treatment showed that @entity4571 did not reverse the @entity730 . However, the treatment retarded @entity730 growth after 4weeks, while in the untreated animals, @entity730 increased in size. The therapy did not affect serum @entity1391 levels, but intact @entity51946 decreased in the treated @entity19 . The treated @entity19 also had increased @entity460 in the heart. In summary, @entity4571 did not alter serum @entity1391 levels, likely due to compensatory decrease in @entity51946 to counteract the @entity1391 lowering effect of @entity4571 . Although increased @entity460 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity730 .

title: @entity4571 treatment in a XXXX model of @entity5 reduces serum @entity51946 and raises heart @entity460 .

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: Mutations in the @entity51945 gene result in @entity5 , characterized by persistent @entity2265 and ectopic calcific masses in soft tissues. Since calcific masses often recur after surgical removal, a more permanent solution to the problem is required. @entity4571 is reported to lower serum @entity1391 by decreasing @entity1372 -dependent @entity1391 co-transporters in the gut and kidney. However, its effectiveness in @entity5 remains unknown. In this study, we investigated @entity4571 as a potential therapy for @entity5 , using a @entity19 model of the disease- @entity51945 knockout @entity19 . Initially, five different doses of @entity4571 were given to normal heterozygous @entity19 intraperitoneally or orally. Treatment had no effect on serum @entity1391 levels, but serum levels of a phosphaturic hormone, @entity51946 ( @entity51946 ), decreased in a dose-dependent manner. Subsequently, high-dose @entity4571 (40mM) was tested in @entity51945 knockout @entity19 fed a high @entity1391 diet. The radiographic data pre- and post-treatment showed that @entity4571 did not reverse the @entity730 . However, the treatment retarded @entity730 growth after 4weeks, while in the untreated animals, @entity730 increased in size. The therapy did not affect serum @entity1391 levels, but intact @entity51946 decreased in the treated @entity19 . The treated @entity19 also had increased @entity460 in the heart. In summary, @entity4571 did not alter serum @entity1391 levels, likely due to compensatory decrease in @entity51946 to counteract the @entity1391 lowering effect of @entity4571 . Although increased @entity460 accumulation in the heart is a concern, the therapy appears to slow down the progression of ectopic @entity730 .

title: @entity4571 treatment in a @entity19 model of @entity5 reduces serum @entity51946 and raises heart XXXX .

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: BACKGROUND: @entity291 vein diameters during compression with two different stocking brands are assessed as well as quality of life. @entity1 AND METHODS: 60 subjects (53 female) with @entity158 were randomized to either wearing the Venotrain micro   (VM) or the Venotrain ulcertec   (VU) compression stocking for 2 weeks. All @entity291 - veins were assessed in cross - sectional plane by Duplexsonography native and through the compression stockings. The diameters of 2 gastrocnemius muscle - veins (GV), the short saphenous vein ( @entity12432 ) and the posterior tibial vein ( @entity343 ) were compared intra - individually, with and without compression. RESULTS: Mean diameters (   SD) decreased significantly under compression (p < 0.0001) in the standing position: in the antero-posterior (ap) plane of the GV by 6.5 (   16.6) % under VU and 8.2 (   16.5) % under VM, in the @entity12432 9.7 (   15.8) % under VU and 5.7 (   19.2) % under VM. No significant change (p = 0.48) was seen in the @entity343 . In the prone position the relative ap - diameter changes in the medial GV were significantly smaller for the VM (37.5    51.0 %) compared to the VU compression stocking (52.4    51.8 %) (p = 0.016). The quality of life assessment scores improved significantly for the VU - and the VM - compression stocking. Venous diameters did not correlate with quality of life scores. CONCLUSIONS: Intra - individually tested the @entity291 muscle vein diameters decrease under compression, more pronounced in the prone than in the standing position. In the ankle area the @entity343 does not decrease in standing subjects. Quality of life assessed increases for both compression stockings.

title: Impact of compression stockings on XXXX -vein diameters and on quality of life parameters in subjects with @entity158 .

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['painful legs']

answer: @entity291 :: (9913,Species) :: ['calf']


abstract: BACKGROUND: @entity291 vein diameters during compression with two different stocking brands are assessed as well as quality of life. @entity1 AND METHODS: 60 subjects (53 female) with @entity158 were randomized to either wearing the Venotrain micro   (VM) or the Venotrain ulcertec   (VU) compression stocking for 2 weeks. All @entity291 - veins were assessed in cross - sectional plane by Duplexsonography native and through the compression stockings. The diameters of 2 gastrocnemius muscle - veins (GV), the short saphenous vein ( @entity12432 ) and the posterior tibial vein ( @entity343 ) were compared intra - individually, with and without compression. RESULTS: Mean diameters (   SD) decreased significantly under compression (p < 0.0001) in the standing position: in the antero-posterior (ap) plane of the GV by 6.5 (   16.6) % under VU and 8.2 (   16.5) % under VM, in the @entity12432 9.7 (   15.8) % under VU and 5.7 (   19.2) % under VM. No significant change (p = 0.48) was seen in the @entity343 . In the prone position the relative ap - diameter changes in the medial GV were significantly smaller for the VM (37.5    51.0 %) compared to the VU compression stocking (52.4    51.8 %) (p = 0.016). The quality of life assessment scores improved significantly for the VU - and the VM - compression stocking. Venous diameters did not correlate with quality of life scores. CONCLUSIONS: Intra - individually tested the @entity291 muscle vein diameters decrease under compression, more pronounced in the prone than in the standing position. In the ankle area the @entity343 does not decrease in standing subjects. Quality of life assessed increases for both compression stockings.

title: Impact of compression stockings on @entity291 -vein diameters and on quality of life parameters in subjects with XXXX .

answer: @entity158 :: (MESH:D010146,Disease) :: ['painful legs']


abstract: The Grynfeltt-Lesshaft @entity547 is a rare posterior abdominal wall defect that allows for the herniation of retro- and intraperitoneal structures through the upper lumbar triangle. While this @entity547 may initially present as a small asymptomatic bulge, the defect typically enlarges over time and can become symptomatic with potentially serious complications. In order to avoid that outcome, it is advisable to electively repair Grynfeltt hernias in @entity1 without significant contraindications to surgery. Due to the limited number of lumbar hernioplasties performed, there has not been a large study that definitively identifies the best repair technique. It is generally accepted that @entity4036 such as these should be repaired by tension-free methods. Both laparoscopic and open techniques are described in modern literature with unique advantages and complications for each. We present the case of an unexpected Grynfeltt @entity547 diagnosed following an attempted @entity362 resection. We chose to perform an open repair involving a combination of fascial approximation and dual-layer @entity7502 mesh placement. The @entity1 's recovery was uneventful and there has been no evidence of recurrence at over six months. Our goal herein is to increase awareness of @entity547 and to discuss approaches to their surgical management.

title: Grynfeltt Hernia: A Deceptive Lumbar Mass with a XXXX -Like Presentation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4036 :: ('MESH:D046449', 'Disease') :: ['abdominal hernias']

entities_list: @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene']

entities_list: @entity547 :: ('MESH:D006547', 'Disease') :: ['upper lumbar hernias', 'hernia']

answer: @entity362 :: (MESH:D008067,Disease) :: ['Lipoma']


abstract: Endogenous @entity7447 ( @entity7447 ) is a lipid-soluble antioxidant and essential for the electron transport chain. We previously demonstrated that @entity273 enhanced @entity7447 levels, whereas disruption of mitochondrial membrane potential by a chemical uncoupler suppressed @entity7447 levels, in @entity1 143B cells. In this study, we investigated how @entity7447 levels and expression of two PDSS and eight COQ genes were affected by @entity4626 , which inhibited @entity855 synthesis at Complex V without uncoupling the mitochondria. We confirmed that @entity4626 increased the production of reactive @entity26 species (ROS) and decreased mitochondria-dependent @entity855 production in 143B cells. We also demonstrated that @entity7447 levels were decreased by @entity4626 after 42 or 48 h of treatment, but not at earlier time points. Expression of @entity26874 and @entity26875 - @entity41384 were up-regulated after 18-hour @entity4626 treatment, and the expression of @entity6217 (PGC1-1a) elevated concurrently. Knockdown of @entity6217 down-regulated the basal mRNA levels of @entity26874 and five COQ genes and suppressed the induction of @entity70791 and @entity41384 genes by @entity4626 , but did not affect @entity7447 levels under these conditions. @entity898 suppressed the augmentation of ROS levels and the enhanced expression of @entity26875 , @entity70792 , @entity43054 , and @entity41384 induced by @entity4626 , but did not modulate the changes in @entity7447 levels. These results suggested that the condition of @entity2383 induced by @entity4626 decreased @entity7447 levels independent of oxidative stress. Up-regulation of @entity26874 and several COQ genes by @entity4626 might be regulated by multiple mechanisms, including the signaling pathways mediated by @entity6217 and ROS, but it would not restore @entity7447 levels.

title: Suppression of coenzyme Q       levels and the induction of multiple PDSS and COQ genes in @entity1 cells following XXXX treatment.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity898 :: ('MESH:D000111', 'Chemical') :: ['N-acetylcysteine']

entities_list: @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide']

entities_list: @entity4626 :: ('MESH:D009840', 'Chemical') :: ['oligomycin']

entities_list: @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']

answer: @entity4626 :: (MESH:D009840,Chemical) :: ['oligomycin']


abstract: Endogenous @entity7447 ( @entity7447 ) is a lipid-soluble antioxidant and essential for the electron transport chain. We previously demonstrated that @entity273 enhanced @entity7447 levels, whereas disruption of mitochondrial membrane potential by a chemical uncoupler suppressed @entity7447 levels, in @entity1 143B cells. In this study, we investigated how @entity7447 levels and expression of two PDSS and eight COQ genes were affected by @entity4626 , which inhibited @entity855 synthesis at Complex V without uncoupling the mitochondria. We confirmed that @entity4626 increased the production of reactive @entity26 species (ROS) and decreased mitochondria-dependent @entity855 production in 143B cells. We also demonstrated that @entity7447 levels were decreased by @entity4626 after 42 or 48 h of treatment, but not at earlier time points. Expression of @entity26874 and @entity26875 - @entity41384 were up-regulated after 18-hour @entity4626 treatment, and the expression of @entity6217 (PGC1-1a) elevated concurrently. Knockdown of @entity6217 down-regulated the basal mRNA levels of @entity26874 and five COQ genes and suppressed the induction of @entity70791 and @entity41384 genes by @entity4626 , but did not affect @entity7447 levels under these conditions. @entity898 suppressed the augmentation of ROS levels and the enhanced expression of @entity26875 , @entity70792 , @entity43054 , and @entity41384 induced by @entity4626 , but did not modulate the changes in @entity7447 levels. These results suggested that the condition of @entity2383 induced by @entity4626 decreased @entity7447 levels independent of oxidative stress. Up-regulation of @entity26874 and several COQ genes by @entity4626 might be regulated by multiple mechanisms, including the signaling pathways mediated by @entity6217 and ROS, but it would not restore @entity7447 levels.

title: Suppression of coenzyme Q       levels and the induction of multiple PDSS and COQ genes in XXXX cells following @entity4626 treatment.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Objective To determine the economic feasibility in Australian general practices of using a practice nurse (PN)-led care model of @entity102 management. Methods A cost-analysis of item numbers from the @entity1442 ( @entity1442 ) was performed in three Australian general practices, one urban, one regional and one rural. @entity1 (n =254; >18 years of age) with chronic conditions (type 2 @entity6 , @entity101 , @entity299 ) but without unstable or major health problems were randomised into usual general practitioner (GP) or PN-led care for management of their condition over a period of 12 months. After the 12-month intervention, total @entity1442 item charges were evaluated for @entity1 managed for their stable chronic condition by usual GP or PN-led care. Zero-skewness log transformation was applied to cost data and log-linear regression analysis was undertaken. Results There was an estimated A 129 mean increase in total @entity1442 item charges over a 1-year period (controlled for age, self-reported quality of life and geographic location of practice) associated with PN-led care. The frequency of GP and PN visits varied markedly according to the @entity102 . Conclusions Medicare reimbursements provided sufficient funding for general practices to employ PNs within limits of workloads before the new Practice Nurse Incentive Program was introduced in July 2012. What is known about the topic? The integration of practice nurses (PN) into the Australian health system is limited compared with the UK and other parts of Europe. There are known @entity1 benefits of PNs collaborating with general practitioners, especially in @entity102 management, but the benefits from a financial perspective are less clear. What does this paper add? The cost-analysis of a PN-led model of @entity102 management in Australian general practice is reported, providing an indication of the financial impact of using PNs in primary healthcare. What are the implications for practitioners? Taking into account general practice and individual PN workloads, sufficient funding for employment of PNs is provided by Medicare reimbursements.

title: Revenue effects of practice nurse-led care for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['MBS', 'Medicare Benefit Schedule']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['ischaemic heart disease']

answer: @entity102 :: (MESH:D002908,Disease) :: ['chronic diseases']


abstract: Xp11.2 @entity1358 ( @entity1358 ) is rare and predominantly found in @entity1 and young adults. Because of the property of overexpressed @entity19409 ( @entity19409 ) fusion protein, immunohistochemical (IHC) staining with @entity19409 antibody makes an excellent diagnostic tool. This study analyzed preliminary experiences of eight Xp11.2 translocation RCCs in our institution between 2007 and 2012. In four males and four females with a mean age of 28.4 years. Xp11.2 translocation RCCs were diagnosed. @entity19409 IHC stain was positive in all @entity5 specimens. As the initial presentation, four @entity1 suffered from @entity490 , three cases had gross @entity811 , and one case had @entity5492 caused by existing lung @entity3 . The @entity5 was located in the right kidney (75%) with mean diameter of 5.85    2.64 cm. Three cases (38%, 3/8) presented with lymph node @entity3 at the time of diagnosis. In five cases (63%, 5/8), the initial diagnosis was Stage III and IV. Treatment included open surgery (one partial nephrectomy and five radical nephrectomies), cryoablation, immunotherapy, and target therapy. The mean follow-up time was 32 months. One @entity1 died after 23.4 months of follow-up. The application of @entity19409 IHC stain will improve the diagnostic accuracy for detecting XP11.2 @entity1358 . Surgery or cryoablation both had excellent prognosis in early stages. Although the disease is believed to be indolent, an increasingly aggressive clinical course should be kept in mind, especially for @entity1 and young adults.

title: The preliminary experiences of XXXX and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['translocation renal cell carcinoma', 'RCC']

entities_list: @entity19409 :: ('7030', 'Gene') :: ['TFE3', 'transcription factor E3']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria']

entities_list: @entity5492 :: ('MESH:D006469', 'Disease') :: ['hemoptysis']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['translocation renal cell carcinoma']


abstract: BACKGROUND: Olfactory loss is highly prevalent, and comorbid @entity1316 are common. Considering olfactory input is highly interconnected with the limbic system, and that the limbic system manages mood, it is predictable that impairments in the sense of smell may result in mood changes. METHODOLOGY: Chronic olfactory deficits were induced by repeated intranasal irrigation of @entity5937 for 12 weeks in BALB/c @entity19 . H_E staining, OMP staining, and @entity415 chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate @entity308 , as well as open field, elevated plus maze tests were applied to assess @entity148 . The mRNA levels of glucocorticoid receptor (GR) and corticotropin releasing hormone ( @entity8740 ) were measured by real-time PCR to confirm relevant molecular changes. RESULTS: Disruption of the olfactory epithelium and olfactory loss was confirmed in histological studies and @entity415 chip finding test. Behavioral tests show that the chronic anosmic state caused increased @entity308 and reduced @entity148 . PCR data showed that mRNA levels of GR in the hypothalamus and @entity8740 in the amygdala were significantly decreased. CONCLUSIONS: These results propose that @entity5937 -induced chronic anosmia can cause a @entity308 and anxiolytic state via decreased hypothalamic GR and amygdalar @entity8740 .

title: Chronic anosmia induces depressive behavior and reduced XXXX via dysregulation of glucocorticoid receptor and @entity8740 in a @entity19 model.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depressive']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders']

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: BACKGROUND: Olfactory loss is highly prevalent, and comorbid @entity1316 are common. Considering olfactory input is highly interconnected with the limbic system, and that the limbic system manages mood, it is predictable that impairments in the sense of smell may result in mood changes. METHODOLOGY: Chronic olfactory deficits were induced by repeated intranasal irrigation of @entity5937 for 12 weeks in BALB/c @entity19 . H_E staining, OMP staining, and @entity415 chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate @entity308 , as well as open field, elevated plus maze tests were applied to assess @entity148 . The mRNA levels of glucocorticoid receptor (GR) and corticotropin releasing hormone ( @entity8740 ) were measured by real-time PCR to confirm relevant molecular changes. RESULTS: Disruption of the olfactory epithelium and olfactory loss was confirmed in histological studies and @entity415 chip finding test. Behavioral tests show that the chronic anosmic state caused increased @entity308 and reduced @entity148 . PCR data showed that mRNA levels of GR in the hypothalamus and @entity8740 in the amygdala were significantly decreased. CONCLUSIONS: These results propose that @entity5937 -induced chronic anosmia can cause a @entity308 and anxiolytic state via decreased hypothalamic GR and amygdalar @entity8740 .

title: Chronic anosmia induces depressive behavior and reduced @entity148 via dysregulation of glucocorticoid receptor and XXXX in a @entity19 model.

answer: @entity8740 :: (12918(Tax:10090),Gene) :: ['corticotropin-releasing hormone']


abstract: BACKGROUND: Olfactory loss is highly prevalent, and comorbid @entity1316 are common. Considering olfactory input is highly interconnected with the limbic system, and that the limbic system manages mood, it is predictable that impairments in the sense of smell may result in mood changes. METHODOLOGY: Chronic olfactory deficits were induced by repeated intranasal irrigation of @entity5937 for 12 weeks in BALB/c @entity19 . H_E staining, OMP staining, and @entity415 chip finding test were performed to confirm olfactory loss. Tail suspension, forced swim, and splash tests were performed to evaluate @entity308 , as well as open field, elevated plus maze tests were applied to assess @entity148 . The mRNA levels of glucocorticoid receptor (GR) and corticotropin releasing hormone ( @entity8740 ) were measured by real-time PCR to confirm relevant molecular changes. RESULTS: Disruption of the olfactory epithelium and olfactory loss was confirmed in histological studies and @entity415 chip finding test. Behavioral tests show that the chronic anosmic state caused increased @entity308 and reduced @entity148 . PCR data showed that mRNA levels of GR in the hypothalamus and @entity8740 in the amygdala were significantly decreased. CONCLUSIONS: These results propose that @entity5937 -induced chronic anosmia can cause a @entity308 and anxiolytic state via decreased hypothalamic GR and amygdalar @entity8740 .

title: Chronic anosmia induces depressive behavior and reduced @entity148 via dysregulation of glucocorticoid receptor and @entity8740 in a XXXX model.

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: The purpose of this study was to determine if bone metastasis characteristics on axial skeleton MRI are associated with either skeletal-related events (SREs) or survival in @entity0 @entity1 . A retrospective review was performed on 247 @entity0 @entity1 with bone metastases identified on axial skeleton MRI. MRI studies were reviewed for metastases T1 signal, signal uniformity, complete vertebral metastatic marrow replacement, metastases quantity, and distribution. Odds ratio (OR) and hazard ratios (HR) were calculated, with 95  % confidence intervals (95  % CI), to determine association with either future SREs or survival. At the time of analysis, 174 (70  %) @entity1 had developed SREs and 176 (71  %) @entity1 were dead. Features of skeletal metastases associated with SREs included the presence of complete metastatic marrow replacement within any vertebra; OR 2.363 (95  % CI 1.240-4.504, P  =  0.0090), and more widely distributed metastases; OR 1.239 (95  % CI 1.070-1.435, P  =  0.0040). Features associated with shorter survival included the presence of complete metastatic marrow replacement within any vertebra; HR 1.500 (95  % CI 1.105-2.036, P  =  0.0093), and more widely distributed metastases; HR 1.141 (95  % CI 1.047-1.243, P  =  0.0027). Metastases T1 signal, signal uniformity, and surprisingly quantity were not associated with SREs or survival. Axial skeleton MRI was able to identify characteristics predictive of future SREs and survival. These characteristics could be used for risk stratification for future trials if prospectively validated.

title: XXXX and bone metastases: the association of axial skeleton MRI findings with skeletal-related events and survival.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast cancer']


abstract: BACKGROUND: The association between maternal @entity308 and adverse outcomes in @entity1 is well established. Similar links have been found for maternal @entity734 . One proposed pathway of risk transmission is reduced maternal emotional availability. Our aim was to investigate whether sensitive parenting is impaired in mothers with @entity308 in remission, and whether among these mothers @entity734 has an additional impact. METHODS: The mother- @entity1 interaction of 188 dyads was assessed during a play situation using the Emotional Availability Scales, which measure the overall affective quality of the interaction: maternal sensitivity, structuring, nonhostility, and nonintrusiveness. Mothers with @entity308 in remission were compared to healthy mothers. @entity1 were between 5 and 12 years old. Group differences and impact of additional @entity734 were analyzed by one-factorial analyses of covariance and planned contrasts. RESULTS: Mothers with @entity308 in remission showed less emotional availability during mother- @entity1 interaction compared to healthy control mothers. Specifically, they were less sensitive and, at trend-level, less structuring and more hostile. Among these mothers, we found an additional effect of severe maternal @entity734 on maternal sensitivity: Mothers with @entity308 in remission and a history of severe @entity734 were less sensitive than remitted mothers without @entity734 . CONCLUSIONS: Our data suggest that @entity308 impacts on maternal emotional availability during remission, which might represent a trait characteristic of @entity308 . Mothers with @entity308 in remission and additional severe @entity734 were particularly affected. These findings may contribute to the understanding of @entity1 's vulnerability to develop a @entity308 themselves.

title: EMOTIONAL AVAILABILITY IN MOTHER- XXXX INTERACTION: THE EFFECTS OF MATERNAL DEPRESSION IN REMISSION AND ADDITIONAL HISTORY OF CHILDHOOD ABUSE.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children', 'child']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder', 'depression']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['childhood abuse']

answer: @entity1 :: (9606,Species) :: ['CHILD']


abstract: OBJECTIVES: To detect metastatic @entity2 of less than 1 mm in size by focusing on the clearance of contrast material using synchrotron radiation (SR) angiography characterized by high spatial resolution and high-sensitivity receiver. METHODS: C6 cells, derived from @entity35 @entity11 cells, were injected to the @entity35 tail vein. Two weeks after injection, the @entity35 underwent SR angiography using a high-gain avalanche rushing amorphous photoconductor (HARP) receiver of extra-high sensitivity with high contrast resolution. The 256-grayscale value was employed in the analysis of images. RESULTS: 19 nodules were identified in images. The @entity5 were confirmed histopathologically. The average @entity5 size was 621  193   m. The clearance curve of the densities was expressed as a logarithm function. @entity5 showed delayed clearance of contrast material, taking up to 28 s, compared with arteries, which cleared rapidly at 8 s. In 256 grayscale, the distance was 50. This gap in density clearance made it possible to identify @entity5 . CONCLUSIONS: SR angiography with a HARP receiver provides high sensitivity and spatial resolution and makes it possible to diagnose metastatic @entity2 of less than 1 mm in size by focusing on differences in the clearance times of contrast material.

title: Focusing on delayed clearance for identifying small-sized metastatic XXXX using synchrotron radiation angiography with a highly sensitive receiver.

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'tumors']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung tumors']


abstract: PURPOSE: The detection of circulating @entity5 cells (CTCs) provides important prognostic information in @entity1 with @entity263 . We aim to determine the rate of detection of CTCs in @entity1 with high-risk non- @entity263 using the CellSearch(  ) method. METHOD: Samples of peripheral blood (7.5  mL) were drawn from 36 @entity1 with newly diagnosed high-risk non- @entity263 , prior to any initiation of therapy and analyzed for CTCs using the CellSearch(  ) method. RESULTS: The median age was 70  years, median PSA was 14.1, and the median Gleason score was 9. The median 5-year risk of progression of disease using a validated nomogram was 39  %. Five out of 36 @entity1 (14  %, 95  % CI 5-30  %) had CTCs detected in their circulation. Four @entity1 had only 1 CTC per 7.5  mL of blood detected. One @entity1 had 3 CTCs per 7.5  mL of blood detected, which included a circulating @entity5 microemboli. Both on univariate analysis and multivariate analysis, there were no correlations found between CTC positivity and the classic prognostic factors including PSA, Gleason score, T-stage and age. CONCLUSION: This study demonstrates that @entity1 with high-risk, non- @entity263 present infrequently with small number of CTCs in peripheral blood. This finding is consistent with the limited literature available in this setting. Other CTC isolation and detection technologies with improved sensitivity and specificity may enable detection of CTCs with mesenchymal phenotypes, although none as yet have been validated for clinical use. Newer assays are emerging for detection of new putative biomarkers for @entity263 . Correlation of disease control outcomes with CTC detection will be important.

title: Circulating @entity5 cell detection in high-risk non- XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['metastatic prostate cancer', 'prostate cancer']

answer: @entity263 :: (MESH:D011471,Disease) :: ['metastatic prostate cancer']


abstract: PURPOSE: The detection of circulating @entity5 cells (CTCs) provides important prognostic information in @entity1 with @entity263 . We aim to determine the rate of detection of CTCs in @entity1 with high-risk non- @entity263 using the CellSearch(  ) method. METHOD: Samples of peripheral blood (7.5  mL) were drawn from 36 @entity1 with newly diagnosed high-risk non- @entity263 , prior to any initiation of therapy and analyzed for CTCs using the CellSearch(  ) method. RESULTS: The median age was 70  years, median PSA was 14.1, and the median Gleason score was 9. The median 5-year risk of progression of disease using a validated nomogram was 39  %. Five out of 36 @entity1 (14  %, 95  % CI 5-30  %) had CTCs detected in their circulation. Four @entity1 had only 1 CTC per 7.5  mL of blood detected. One @entity1 had 3 CTCs per 7.5  mL of blood detected, which included a circulating @entity5 microemboli. Both on univariate analysis and multivariate analysis, there were no correlations found between CTC positivity and the classic prognostic factors including PSA, Gleason score, T-stage and age. CONCLUSION: This study demonstrates that @entity1 with high-risk, non- @entity263 present infrequently with small number of CTCs in peripheral blood. This finding is consistent with the limited literature available in this setting. Other CTC isolation and detection technologies with improved sensitivity and specificity may enable detection of CTCs with mesenchymal phenotypes, although none as yet have been validated for clinical use. Newer assays are emerging for detection of new putative biomarkers for @entity263 . Correlation of disease control outcomes with CTC detection will be important.

title: Circulating XXXX cell detection in high-risk non- @entity263 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: The aim of the present study was to find out whether early cardiac changes in @entity1 receiving chemotherapy can be detected by the conventional and deformation parameters of 2D and 3D echocardiography. Twenty-five healthy subjects with normal regional left ventricular function (group 1) and 25 @entity1 receiving chemotherapy (group 2) underwent 2D and 3D transthoracic echocardiography (Toshiba Artida Medical System). All @entity1 (group 2) were examined before and during @entity1370 chemotherapy at a 3-month follow-up. Left ventricular volumes, ejection fraction, muscle mass, global longitudinal, global radial, global circumferential strain, and rotation were analyzed with 2D and 3D echocardiography, while twist and time-to-peak-intervals were analyzed with 3D echocardiography. For left ventricular volumes and muscle mass, no significant differences were seen between the two study groups (P<0.05). According to our results, @entity296 induced by @entity1370 chemotherapy can be detected by 2D global radial strain. Detecting @entity296 by global longitudinal and circumferential strain requires more than 3 months follow-up. Changes in rotation, twist or time-to-peak intervals could not be verified at the 3-month follow-up in the present study. 2D global radial strain seems to be the most sensitive and robust parameter to detect early @entity296 during chemotherapy. 3D echocardiography is not yet an established method to detect @entity296 in clinical practice due to lower spatial and temporal resolution.

title: Early detection of XXXX by 2D and 3D deformation imaging in @entity1 receiving chemotherapy.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage', 'myocardial dysfunction']

entities_list: @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxic']

answer: @entity1370 :: (MESH:D066126,Disease) :: ['cardiotoxicity']


abstract: The aim of the present study was to find out whether early cardiac changes in @entity1 receiving chemotherapy can be detected by the conventional and deformation parameters of 2D and 3D echocardiography. Twenty-five healthy subjects with normal regional left ventricular function (group 1) and 25 @entity1 receiving chemotherapy (group 2) underwent 2D and 3D transthoracic echocardiography (Toshiba Artida Medical System). All @entity1 (group 2) were examined before and during @entity1370 chemotherapy at a 3-month follow-up. Left ventricular volumes, ejection fraction, muscle mass, global longitudinal, global radial, global circumferential strain, and rotation were analyzed with 2D and 3D echocardiography, while twist and time-to-peak-intervals were analyzed with 3D echocardiography. For left ventricular volumes and muscle mass, no significant differences were seen between the two study groups (P<0.05). According to our results, @entity296 induced by @entity1370 chemotherapy can be detected by 2D global radial strain. Detecting @entity296 by global longitudinal and circumferential strain requires more than 3 months follow-up. Changes in rotation, twist or time-to-peak intervals could not be verified at the 3-month follow-up in the present study. 2D global radial strain seems to be the most sensitive and robust parameter to detect early @entity296 during chemotherapy. 3D echocardiography is not yet an established method to detect @entity296 in clinical practice due to lower spatial and temporal resolution.

title: Early detection of @entity1370 by 2D and 3D deformation imaging in XXXX receiving chemotherapy.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: When @entity65 are viewed from an evolutionary biology perspective, a heightened thrifty and an inflammatory design could be their mechanisms. @entity1 ancestors confronted a greater infectious load and were subjected to the selection for proinflammatory genes and a strong inflammatory function. Ancestors also faced starvation periods that pressed for a thrifty genotype which caused fat accumulation. The pressure of sustaining gluconeogenesis during periods of poor nourishment selected individuals with insulin resistance. Obesity induces a proinflammatory state due to the secretion of adipokines which underlie @entity66 . Our actual lifestyle needs no more of such proinflammatory and thrifty genotypes and these ancestral genes might increase predisposition to diseases. Risk factors for @entity731 and @entity6 are based on inflammatory and genetic foundations that can be accounted for by excess fat. Longevity has also increased in recent times and is related to a proinflammatory response with cardiovascular consequences. If @entity1 ancestral lifestyle could be recovered by increasing exercise and adapting a calorie restriction diet, @entity28 would decrease and the effects on chronic low-grade @entity32 would be limited. Thereby, the rates of both @entity731 and @entity6 could be reduced.

title: An Evolutionary Perspective of Nutrition and Inflammation as Mechanisms of XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cardiometabolic diseases']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity65 :: (MESH:D002318,Disease) :: ['Cardiovascular Disease']


abstract: BACKGROUND: Assessment of bone quality can guide spinal surgery. However, surgeons infrequently evaluate bone quality in a quantitative manner. Recent literature suggests a role for computed tomography (CT) Hounsfield units (HUs) as a marker for bone quality. Limited data exist regarding its utility with respect to posterolateral lumbar fusion (PLF). METHODS: From fall 2010 to winter 2012, 10 @entity1 underwent revision surgery for symptomatic @entity1516 (defined as intractable @entity158 associated with either radiographic evidence of nonunion or intraoperative evidence of nonunion) after a prior L4-S1 PLF. These @entity1 were age-matched (  5 years) to 10 @entity1 who underwent L4-S1 PLF with no clinical signs of @entity1516 at 1-year follow-up. Available CT imaging (with or without instrumentation) was evaluated from L1 to L5 for the averaged HU. Data were pooled among L1-L3 values and between L4 and L5 values. RESULTS: Within the @entity1516 group, the pooled L1-L3 HU value was similar to the pooled L4-L5 HU value (168.39    22.84 HU vs. 166.98    23.20 HU respectively, P = 0.89). The same pattern was observed for the control group (190.24    37.13 HU vs. 201.89    36.59 HU respectively, P = 0.44). On the other hand, the pooled L1-L3 and L4-L5 HU values were larger for the control group compared to the @entity1516 group, with the pooled L4-L5 HU demonstrating statistical significance, P = 0.01. CONCLUSION: Currently, CT imaging is typically not obtained prior to lumbar fusion. Results demonstrated that CT HU values were significantly larger for @entity1 who did not exhibit symptomatic @entity1516 at 1-year follow-up compared to those who required revision surgery. As such, CT HU values may serve as a predictor for bony fusion to guide surgical management of @entity1 under consideration for PLF.

title: Posterolateral lumbar fusion: Relationship between computed tomography Hounsfield units and symptomatic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1516 :: ('MESH:D011542', 'Disease') :: ['pseudoarthrosis']

answer: @entity1516 :: (MESH:D011542,Disease) :: ['pseudoarthrosis']


abstract: BACKGROUND: Aim of the present study was to evaluate prognostic factors, in particular standard laboratory parameters, for better outcome after @entity1274 (SSNHL). METHODS: Using a retrospective review, 173 @entity1 were included presenting between 2006 and 2009 with unilateral SSNHL, >= 30  dB bone conduction in three succeeding frequencies between 0.125 to 8  kHz in pure tone audiometry (PTA), and a time interval between first symptoms and diagnostics    <=   4  weeks. Hearing gain of <10  dB versus >= 10  dB in the affected ear in 6PTA values was the primary outcome criterion. Univariate and multivariate statistical tests were used to analyze predictors for better outcome. RESULTS: The initial @entity393 was 50.6        27.2  dB. The absolute @entity393 was 15.6        20.1  dB. Eighty-one @entity1 (47%) had a final @entity393 of >= 10  dB. @entity4365 (p <0.0001); start of inpatient treatment <4  days after onset (p   =   0.018); first SSNHL (versus recurrent SSNHL, p   =   0.001); initial @entity393   >=    60  dB (p   <   0.0001); an initial quick value lower than the reference values (p   =   0.040); and a pretherapeutic hyperfibrinogenemia (p   =   0.007) were significantly correlated to better outcome (>= 10  dB absolute @entity393 ). Multivariate analysis revealed that first SSNHL (p   =   0.004), start of treatment <4  days after onset (p   =   0.015), initial @entity393   >=    60  dB (p   =   0.001), and hyperfibrinogenemia (p   =   0.032) were independent prognostic factors for better hearing recovery. CONCLUSION: Better @entity393 in @entity1 with hyperfibrinogenemia might be explained by the rheological properties of the applied therapy and supports the hypothesis that SSNHL is caused in part by vascular factors.

title: Prognostic impact of standard laboratory values on outcome in @entity1 with sudden XXXX .

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing gain', 'hearing loss']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['idiopathic sudden sensorineural hearing loss']

entities_list: @entity4365 :: ('MESH:C565121', 'Disease') :: ['Low-frequency hearing loss']

answer: @entity1274 :: (MESH:D006319,Disease) :: ['sensorineural hearing loss']


abstract: BACKGROUND: Aim of the present study was to evaluate prognostic factors, in particular standard laboratory parameters, for better outcome after @entity1274 (SSNHL). METHODS: Using a retrospective review, 173 @entity1 were included presenting between 2006 and 2009 with unilateral SSNHL, >= 30  dB bone conduction in three succeeding frequencies between 0.125 to 8  kHz in pure tone audiometry (PTA), and a time interval between first symptoms and diagnostics    <=   4  weeks. Hearing gain of <10  dB versus >= 10  dB in the affected ear in 6PTA values was the primary outcome criterion. Univariate and multivariate statistical tests were used to analyze predictors for better outcome. RESULTS: The initial @entity393 was 50.6        27.2  dB. The absolute @entity393 was 15.6        20.1  dB. Eighty-one @entity1 (47%) had a final @entity393 of >= 10  dB. @entity4365 (p <0.0001); start of inpatient treatment <4  days after onset (p   =   0.018); first SSNHL (versus recurrent SSNHL, p   =   0.001); initial @entity393   >=    60  dB (p   <   0.0001); an initial quick value lower than the reference values (p   =   0.040); and a pretherapeutic hyperfibrinogenemia (p   =   0.007) were significantly correlated to better outcome (>= 10  dB absolute @entity393 ). Multivariate analysis revealed that first SSNHL (p   =   0.004), start of treatment <4  days after onset (p   =   0.015), initial @entity393   >=    60  dB (p   =   0.001), and hyperfibrinogenemia (p   =   0.032) were independent prognostic factors for better hearing recovery. CONCLUSION: Better @entity393 in @entity1 with hyperfibrinogenemia might be explained by the rheological properties of the applied therapy and supports the hypothesis that SSNHL is caused in part by vascular factors.

title: Prognostic impact of standard laboratory values on outcome in XXXX with sudden @entity1274 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To evaluate the early clinical results of keratoconic eyes treated with transepithelial iontophoresis corneal collagen cross-linking (i-CXL) within 1 year. METHODS: Propective nonrandomized study. Twenty-three eyes of 23 @entity1 with progressive @entity9042 with minimum corneal thickness from 380   m to 420   m (including the epithelium) were included in this prospective, nonrandomized clinical study and treated with i-CXL. Scoring of @entity158 , slit lamp examination, uncorrected visual acuity (UCVA) and best corrected distance visual acuity (BCVA), corneal topography, anterior segment optical coherence tomography (AS-OCT), in vivo corneal confocal microscopy and endothelial cell count were assessed before surgery and at 1, 3, 6 and 12 months (m) postoperatively. Paired t test was applied for statistical analysis. RESULTS: Moderate @entity158 were reported by most @entity1 on postoperative Day (D) 1, but rapidly decreased and eventually disappeared on D3. Mild epithelial damage was observed on D1, and the epithelium fully recovered on D3. Improvement of UCVA and BCVA were recorded at 3 months and 12 months postoperatively. Orbscan II corneal topography revealed the significant reductions of Kmax and @entity28680 from 3m to 12m (Kmax, t = 2.912, P < 0.01, @entity28680 , t = 2.508, P < 0.05) postoperatively while the other parameters remained stable. The Kmax and @entity28680 at 12m was (52.94    4.87) and (46.78    3.71) respectively, while the preoperative values was (54.37    5.56) and (48.53    3.57) respectively. Within 1m postoperatively, AS-OCT exhibited an increase of reflectance with a white line (demarcation line) in the anterior stroma, in vivo confocal microscopy also showed the significant thickening and increased connections of collagen fibers with maximal depth of about 133   m. The corneal endothelial cell density remained stable (t = 0.915, P > 0.05). None of the @entity1 showed @entity260 such as @entity281 , scarring, @entity1066 , persistent epithelial defect, etc. CONCLUSIONS: Priliminary clinical results within 1 year postoperatively demonstrated the efficacy and safety of i-CXL for the management of progressive @entity9042 . This technique was applicable for keratoconic eyes with minimum corneal thickness around 400   m. i-CXL showed the advantage of short time consuming in surgery, rapid recovery and few complication, and has the potential to become a valid alternative for the treatment of @entity9042 .

title: [Transepithelial iontophoresis corneal collagen cross-linking for progressive XXXX : one year results].

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['corneal infection']

entities_list: @entity9042 :: ('MESH:D007640', 'Disease') :: ['keratoconus']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain and foreign body sensation']

answer: @entity9042 :: (MESH:D007640,Disease) :: ['keratoconus']


abstract: BACKGROUND AND OBJECTIVES: The objective was to compare the dietary intakes of individuals with @entity1723 ( @entity1723 ) to individuals without @entity6 in China. METHODS AND STUDY DESIGN: Data are from 1) the 3C Nutrition Ancillary Study, a cross-sectional study of individuals with @entity1723 in China, and 2) the China Health and Nutrition Survey. Dietary intake in both samples was assessed using three 24-hour recalls. ANCOVA and multivariable logistic regression, adjusted for sex, age, and urban-rural residence, were used to assess differences in nutrient and food group intake between @entity1 without @entity6 (n=1059) and @entity1 with @entity1723 (n=97), who were stratified by insulin regimen (basal-bolus, n=49, versus fixed, n=48). RESULTS: @entity1 with @entity1723 had a lower percentage of energy from @entity3363 , higher vegetable intake, and were more likely to consume lowfat cakes and fungi/sea weed compared to @entity1 without @entity6 (all p<0.05). Distinguishing characteristics of insulin regimen groups also emerged. @entity1 on fixed regimens had higher intakes of @entity3505 and were less likely to consume fruit and more likely to consume high-fat cakes and dairy compared to @entity1 without @entity6 (all p<0.05). @entity1 on basal-bolus regimens were less likely to consume fried foods and more likely to consume fish/shellfish compared to @entity1 without @entity6 (all p<0.05). CONCLUSIONS: Differences in dietary intake between @entity1 with and without @entity1723 in China suggest that dietary modifications are common and reflect @entity1735 -conscious nutrition recommendations for individuals with @entity1723 . Future research should focus on the health effects of these modifications.

title: Comparison of the dietary intakes of individuals with and without XXXX in China.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['T1D', 'type 1 diabetes']

entities_list: @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']

answer: @entity1723 :: (MESH:D003922,Disease) :: ['type 1 diabetes']


abstract: BACKGROUND: The present study summarizes the 11-year laparoscopic @entity356 surgery experience of a single institution in South Korea and evaluates the current trends of laparoscopic @entity356 surgery through our experience. METHODS: A total of 3000 minimally invasive @entity356 surgeries were performed at Seoul National University Bundang Hospital between May 2003 and January 2014. The types of laparoscopic gastrectomy used, surgical techniques, postoperative morbidities, and long-term oncologic outcomes were analyzed. RESULTS: The proportion of challenging procedures such as laparoscopic total gastrectomy and laparoscopic gastrectomy for @entity1 with advanced @entity356 increased during the study period. The frequency of laparoscopic function-preserving gastrectomy for @entity1 with early-stage @entity5 also increased. The overall rate of complications was 16.7  %; surgical and systemic complication rates were 11.8 and 6.2  %, respectively. There was one case of postoperative mortality due to delayed @entity548 after discharge. Male gender, high BMI, long operating times, combined resection of other organs, and total and proximal gastrectomies were independent predictors of surgical morbidities; however, pathologic T-stage was not a predictable factor. Accumulated experience in laparoscopic surgery decreased the surgical complication rates of total and proximal gastrectomies more than it did in distal gastrectomy over time. The 5-year overall survival rates of @entity1 in advanced stages and those who underwent laparoscopic total gastrectomy were comparable to those reported previously. CONCLUSIONS: Our results indicate the trends toward the expansion of laparoscopic approaches to technically demanding procedures and an increased use of laparoscopic function-preserving surgeries for @entity1 with EGC with acceptable outcomes.

title: Eleven-year experience with 3000 cases of laparoscopic XXXX surgery in a single institution: analysis of postoperative morbidities and long-term oncologic outcomes.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: BACKGROUND: @entity7415 and @entity7416 , cell surface receptors of @entity687 , regulate cell migration and alteration of their expression has been associated with poor prognosis of @entity5 . The aim of this study was to detect their expression in @entity356 to identify associations with another cell adhesion molecule, @entity1495 ( @entity1495 ), and with clinicopathological data ex vivo, and then explore their potential role in @entity356 cells in vitro. MATERIALS AND METHODS: A total of 172 cases of @entity356 tissue specimens were collected for immunohistochemical analysis of @entity7415 , @entity7416 , and @entity1495 expression. Expression of @entity7415 and @entity7416 proteins was knocked in or down using their cDNA and shRNA, respectively, in @entity356 cell lines to assess the changed cell phenotypes and gene expression. RESULTS: @entity7415 , @entity7416 , and @entity1495 were expressed in 61.0%, 77.9%, and 75.6% of @entity356 tissues, respectively. Moreover, @entity7415 and @entity7416 expression was associated with @entity5 differentiations, advanced clinical stages, lymph node, and distant @entity3 of @entity356 . Similarly, @entity1495 expression was associated with @entity7415 and @entity7416 . Expression of these three proteins was interrelated. In vitro study showed that levels of @entity7415 and @entity7416 proteins were associated with the capacity of @entity356 cell migration, while knockdown of their expression inhibited @entity356 cell migration and invasion abilities in vitro. In contrast, overexpression of @entity7415 and @entity7416 proteins promoted @entity5 cell migration and invasion. At the gene levels, knockdown of @entity7415 or @entity7416 expression suppressed expression of @entity12136 , @entity7242 , and @entity4675 proteins and phosphorylated @entity1178 and @entity1366 . Conversely, upregulation of @entity7415 or @entity7416 promoted expression of @entity12136 , @entity7242 , @entity4675 , and @entity1178 proteins and phosphorylated @entity4675 , @entity1178 and @entity1366 . CONCLUSIONS: These findings suggest that @entity7415 and @entity7416 play an important role in @entity356 progression. Further study will be performed to investigate whether target of their expression can be used as a novel strategy in clinical control of @entity356 @entity3 .

title: Association of CXCR1 and 2 expressions with XXXX @entity3 in ex vivo and @entity5 cell invasion in vitro.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'various cancers']

entities_list: @entity1495 :: ('4318', 'Gene') :: ['matrix metalloproteinase-9', 'MMP9']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: BACKGROUND: @entity7415 and @entity7416 , cell surface receptors of @entity687 , regulate cell migration and alteration of their expression has been associated with poor prognosis of @entity5 . The aim of this study was to detect their expression in @entity356 to identify associations with another cell adhesion molecule, @entity1495 ( @entity1495 ), and with clinicopathological data ex vivo, and then explore their potential role in @entity356 cells in vitro. MATERIALS AND METHODS: A total of 172 cases of @entity356 tissue specimens were collected for immunohistochemical analysis of @entity7415 , @entity7416 , and @entity1495 expression. Expression of @entity7415 and @entity7416 proteins was knocked in or down using their cDNA and shRNA, respectively, in @entity356 cell lines to assess the changed cell phenotypes and gene expression. RESULTS: @entity7415 , @entity7416 , and @entity1495 were expressed in 61.0%, 77.9%, and 75.6% of @entity356 tissues, respectively. Moreover, @entity7415 and @entity7416 expression was associated with @entity5 differentiations, advanced clinical stages, lymph node, and distant @entity3 of @entity356 . Similarly, @entity1495 expression was associated with @entity7415 and @entity7416 . Expression of these three proteins was interrelated. In vitro study showed that levels of @entity7415 and @entity7416 proteins were associated with the capacity of @entity356 cell migration, while knockdown of their expression inhibited @entity356 cell migration and invasion abilities in vitro. In contrast, overexpression of @entity7415 and @entity7416 proteins promoted @entity5 cell migration and invasion. At the gene levels, knockdown of @entity7415 or @entity7416 expression suppressed expression of @entity12136 , @entity7242 , and @entity4675 proteins and phosphorylated @entity1178 and @entity1366 . Conversely, upregulation of @entity7415 or @entity7416 promoted expression of @entity12136 , @entity7242 , @entity4675 , and @entity1178 proteins and phosphorylated @entity4675 , @entity1178 and @entity1366 . CONCLUSIONS: These findings suggest that @entity7415 and @entity7416 play an important role in @entity356 progression. Further study will be performed to investigate whether target of their expression can be used as a novel strategy in clinical control of @entity356 @entity3 .

title: Association of CXCR1 and 2 expressions with @entity356 XXXX in ex vivo and @entity5 cell invasion in vitro.

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: BACKGROUND: @entity7415 and @entity7416 , cell surface receptors of @entity687 , regulate cell migration and alteration of their expression has been associated with poor prognosis of @entity5 . The aim of this study was to detect their expression in @entity356 to identify associations with another cell adhesion molecule, @entity1495 ( @entity1495 ), and with clinicopathological data ex vivo, and then explore their potential role in @entity356 cells in vitro. MATERIALS AND METHODS: A total of 172 cases of @entity356 tissue specimens were collected for immunohistochemical analysis of @entity7415 , @entity7416 , and @entity1495 expression. Expression of @entity7415 and @entity7416 proteins was knocked in or down using their cDNA and shRNA, respectively, in @entity356 cell lines to assess the changed cell phenotypes and gene expression. RESULTS: @entity7415 , @entity7416 , and @entity1495 were expressed in 61.0%, 77.9%, and 75.6% of @entity356 tissues, respectively. Moreover, @entity7415 and @entity7416 expression was associated with @entity5 differentiations, advanced clinical stages, lymph node, and distant @entity3 of @entity356 . Similarly, @entity1495 expression was associated with @entity7415 and @entity7416 . Expression of these three proteins was interrelated. In vitro study showed that levels of @entity7415 and @entity7416 proteins were associated with the capacity of @entity356 cell migration, while knockdown of their expression inhibited @entity356 cell migration and invasion abilities in vitro. In contrast, overexpression of @entity7415 and @entity7416 proteins promoted @entity5 cell migration and invasion. At the gene levels, knockdown of @entity7415 or @entity7416 expression suppressed expression of @entity12136 , @entity7242 , and @entity4675 proteins and phosphorylated @entity1178 and @entity1366 . Conversely, upregulation of @entity7415 or @entity7416 promoted expression of @entity12136 , @entity7242 , @entity4675 , and @entity1178 proteins and phosphorylated @entity4675 , @entity1178 and @entity1366 . CONCLUSIONS: These findings suggest that @entity7415 and @entity7416 play an important role in @entity356 progression. Further study will be performed to investigate whether target of their expression can be used as a novel strategy in clinical control of @entity356 @entity3 .

title: Association of CXCR1 and 2 expressions with @entity356 @entity3 in ex vivo and XXXX cell invasion in vitro.

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: When @entity1426 (AA) was given to a @entity95 which was previously heparinized, its arterial pressure began to fall. Indomethacin erased this vasodepressive power without modifying the sensitivity of the cardiovascular apparatus to @entity2918 . Thus, it seems to depend on the biosynthesis of the @entity2918 . This @entity551 action is used as an indication of natural factors which modify the biosynthesis of @entity2918 in living subjects. @entity2340 was used on 8 male @entity95 who had been fed normally, weighing 2.3-2.8 kg. The standard dose of .12 mg/kg of AA was injected in 80 seconds. 3 experiments were done without heparin, using a manometer in which the liquid had been made incoaguable by @entity1792 . With 5 others, after injection of AA, the isotonic liquid with @entity1792 was replaced by a manometer with heparin (20 mg/kg of heparin to avoid reabsorption of @entity1792 during @entity551 ). Several injections of AA were given until a constant @entity551 action resulted; then 4 mg/kg of @entity2340 were given and 10 minutes later, a new injection of AA. The results were: 1) With .12 mg/kg there was no @entity551 effect in the @entity95 without heparin. 2) A previous treatment with 4 mg/kg of @entity2340 achieved a fall of 5-15%. 3) In heparinized @entity95 , after AA injections, there were falls of pressure which intensified and attained 25% 40 minutes after the heparin injection. 4) The injection of @entity2340 obtained @entity551 of 45-50% in 5 @entity95 . It is concluded that in @entity95 @entity2340 is an activator of the biosynthesis of @entity2918 .

title: [Proceedings: Influence of @entity2340 on the XXXX effect of @entity1426 ].

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins']

entities_list: @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['Tryptophan', 'tryptophan']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive', 'hypotensions', 'hypotension']

answer: @entity551 :: (MESH:D007022,Disease) :: ['hypotensive']


abstract: When @entity1426 (AA) was given to a @entity95 which was previously heparinized, its arterial pressure began to fall. Indomethacin erased this vasodepressive power without modifying the sensitivity of the cardiovascular apparatus to @entity2918 . Thus, it seems to depend on the biosynthesis of the @entity2918 . This @entity551 action is used as an indication of natural factors which modify the biosynthesis of @entity2918 in living subjects. @entity2340 was used on 8 male @entity95 who had been fed normally, weighing 2.3-2.8 kg. The standard dose of .12 mg/kg of AA was injected in 80 seconds. 3 experiments were done without heparin, using a manometer in which the liquid had been made incoaguable by @entity1792 . With 5 others, after injection of AA, the isotonic liquid with @entity1792 was replaced by a manometer with heparin (20 mg/kg of heparin to avoid reabsorption of @entity1792 during @entity551 ). Several injections of AA were given until a constant @entity551 action resulted; then 4 mg/kg of @entity2340 were given and 10 minutes later, a new injection of AA. The results were: 1) With .12 mg/kg there was no @entity551 effect in the @entity95 without heparin. 2) A previous treatment with 4 mg/kg of @entity2340 achieved a fall of 5-15%. 3) In heparinized @entity95 , after AA injections, there were falls of pressure which intensified and attained 25% 40 minutes after the heparin injection. 4) The injection of @entity2340 obtained @entity551 of 45-50% in 5 @entity95 . It is concluded that in @entity95 @entity2340 is an activator of the biosynthesis of @entity2918 .

title: [Proceedings: Influence of XXXX on the @entity551 effect of @entity1426 ].

answer: @entity2340 :: (CHEBI:27897,Chemical) :: ['tryptophan']


abstract: When @entity1426 (AA) was given to a @entity95 which was previously heparinized, its arterial pressure began to fall. Indomethacin erased this vasodepressive power without modifying the sensitivity of the cardiovascular apparatus to @entity2918 . Thus, it seems to depend on the biosynthesis of the @entity2918 . This @entity551 action is used as an indication of natural factors which modify the biosynthesis of @entity2918 in living subjects. @entity2340 was used on 8 male @entity95 who had been fed normally, weighing 2.3-2.8 kg. The standard dose of .12 mg/kg of AA was injected in 80 seconds. 3 experiments were done without heparin, using a manometer in which the liquid had been made incoaguable by @entity1792 . With 5 others, after injection of AA, the isotonic liquid with @entity1792 was replaced by a manometer with heparin (20 mg/kg of heparin to avoid reabsorption of @entity1792 during @entity551 ). Several injections of AA were given until a constant @entity551 action resulted; then 4 mg/kg of @entity2340 were given and 10 minutes later, a new injection of AA. The results were: 1) With .12 mg/kg there was no @entity551 effect in the @entity95 without heparin. 2) A previous treatment with 4 mg/kg of @entity2340 achieved a fall of 5-15%. 3) In heparinized @entity95 , after AA injections, there were falls of pressure which intensified and attained 25% 40 minutes after the heparin injection. 4) The injection of @entity2340 obtained @entity551 of 45-50% in 5 @entity95 . It is concluded that in @entity95 @entity2340 is an activator of the biosynthesis of @entity2918 .

title: [Proceedings: Influence of @entity2340 on the @entity551 effect of XXXX ].

answer: @entity1426 :: (MESH:D016718,Chemical) :: ['arachidonic acid']


abstract: OBJECTIVES: An exaggerated blood pressure (BP) response to exercise is associated with adverse cardiovascular outcomes, even in normotensive individuals. The purpose of this study was to compare myocardial function between normotensive individuals with and without an exaggerated BP response. METHODS: We evaluated global myocardial function using speckle tracking echocardiography in normotensive individuals. Two-dimensional speckle tracking echocardiography and a treadmill exercise test were performed simultaneously in 171 normotensive individuals (mean age: 48  8 years; 97 @entity1 ) without any structural @entity299 . RESULTS: Among 171 normotensive individuals, 19 (11%) exhibited an exaggerated BP response (>= 200 mmHg for @entity1 and >= 190 mmHg for @entity1 ) during the treadmill test. Conventional echocardiographic parameters were similar between the two groups. However, on strain analyses, the systolic and early @entity6475 of the left ventricle (LV) and left atrium were lower in individuals with an exaggerated BP response to exercise. The peak @entity13519 during exercise was inversely related to @entity299 of the LV (r=-0.35, P<0.01) and left atrium (r=-0.41, P<0.01). On multivariate analyses, an exaggerated BP response to exercise was shown to be an independent determinant of reduced global longitudinal strain of the LV (b=-0.20, P<0.05) and left atrium (b=-0.28, P<0.05). CONCLUSION: Normotensive individuals with an exaggerated BP response to exercise exhibit @entity296 . Even without apparent @entity101 , an exaggerated BP response could cause repeated increases in afterload and result in subclinical @entity296 .

title: An exaggerated blood pressure response to exercise is associated with subclinical XXXX in normotensive individuals.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['impairment in longitudinal myocardial function', 'myocardial dysfunction']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6475 :: ('MESH:D013180', 'Disease') :: ['diastolic global longitudinal strains']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['systolic global longitudinal strain', 'heart disease']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial dysfunction']


abstract: PURPOSE: @entity11702 ( @entity11702 , MIM#310600) is an @entity1112 characterized by severe @entity21747 at birth. We report the results of causative @entity48178 gene analysis in three male siblings with @entity11702 and describe the associated phenotypes. METHODS: Three brothers with suspected @entity11702 and their mother presented for clinical examination. After obtaining informed consent, DNA was extracted from the peripheral blood of the proband, one of his brothers and his unaffected mother. Exons 1-3 of the @entity48178 gene were amplified by polymerase chain reaction (PCR), and direct sequencing was performed. Multiplex ligation-dependent probe amplification (MLPA) was also performed to search for copy number variants in the @entity48178 gene. RESULTS: The clinical findings of the three brothers included no light perception, @entity5575 , @entity8707 , leukocoria, @entity1713 and @entity1032 . Exon 2 of the @entity48178 gene was not amplified in the proband and one brother, even when the PCR primers for exon 2 were changed, whereas the other two exons showed no mutations by direct sequencing. MLPA analysis showed deletion of exon 2 of the @entity48178 gene in the proband and one brother, while there was only one copy of exon 2 in the mother. CONCLUSION: @entity11702 was diagnosed in three @entity1 from a Japanese family by clinical examination and was confirmed by genetic analysis. To localize the defect, confirmation of copy number variation by the MLPA method was useful in the present study.

title: Familial cases of XXXX detected by copy number analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation']

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['total retinal detachment']

entities_list: @entity1112 :: ('MESH:D040181', 'Disease') :: ['X-linked disorder']

entities_list: @entity5575 :: ('MESH:D003318', 'Disease') :: ['corneal opacity']

entities_list: @entity8707 :: ('MESH:C535679', 'Disease') :: ['shallow anterior chamber']

entities_list: @entity21747 :: ('MESH:D015792', 'Disease') :: ['vitreoretinal dysplasia']

entities_list: @entity11702 :: ('MESH:C537849', 'Disease') :: ['Norrie disease', 'ND']

answer: @entity11702 :: (MESH:C537849,Disease) :: ['Norrie disease']


abstract: BACKGROUND: @entity834 remains a concern in general surgical practice. The significance lies in the resultant @entity1661 , related morbidity and mortality, risk of @entity393 , permanent stoma creation and the effect on local recurrence and overall @entity1 survival in @entity14 cases. OBJECTIVES: This study serves to determine the leak rates and the mortality thereof related to colonic and rectal anastomoses at the University Hospital of the West Indies (UHWI) in Kingston, Jamaica. Independent factors contributing to @entity834 in these @entity1 will also be assessed and correlations determined. METHODS: A review of the medical records of one hundred and thirty-three cases of colonic and rectal anastomoses identified retrospectively over a three-year period provided relevant information for analysis. RESULTS: @entity834 were identified in twelve @entity1 , providing a leak rate of 9.0%. No 30-day mortality related to @entity834 was noted. Based on a multivariate analysis, male gender was identified as the sole independent factor related to @entity834 . Conclusion: Colorectal anastomotic leak rates at UHWI fell at the upper limit of leak rates typically quoted in the literature. No modifiable risk factor appeared to contribute to this leak rate. Early identification and intervention is critical in limiting mortality associated with @entity14 .

title: XXXX at the university hospital of the west indies: an analysis of risk factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['Anastomotic leakage', 'Anastomotic leaks', 'anastomotic leaks', 'anastomotic leakage']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal sepsis']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer', 'colorectal anastomotic leakage']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['anastomotic loss']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal anastomotic leakage']