abstract: BACKGROUND: Major @entity308 is diagnosed in 18% of @entity1 following @entity583 ( @entity583 ), and the antidepressant @entity905 is shown to effectively decrease @entity308 and improve @entity301 prognosis. We observed the effect of @entity905 on cardiac electrophysiology in vivo in a @entity35 model of @entity583 and the potential mechanism. METHODS AND RESULTS: Eighty adult male @entity35 (200-250 g) were randomly assigned to five groups: normal control (control group), @entity583 ( @entity583 group), @entity308 ( @entity308 group), @entity583 (model group), and @entity583 treated with intragastric administration of 10 mg/kg @entity905 ( @entity905 group). @entity583 was induced by left anterior descending coronary artery ligation. @entity308 was developed by 4-week chronic mild stress (CMS). Behavior measurement was done before and during the experiment. Electrophysiology study in vivo and Western blot analysis were carried on after 4 weeks of CMS. After 4 weeks of CMS, @entity308 -like behaviors were observed in the @entity583 , @entity308 , and model groups, and chronic @entity905 administration could significantly improve those behaviors (P<0.05 vs model group). @entity905 significantly increased the @entity2224 threshold compared with the model group (20.20  9.32 V vs 14.67  1.85 V, P<0.05). Expression of @entity26739 was significantly reduced by 29%  12%, 24%  6%, and 41%  15%, respectively, in the @entity583 group, CMS group, and model group, which could be improved by @entity905 (30%  9%). But @entity905 showed no improvement on the @entity583 -induced loss of @entity10277 . CONCLUSION: The susceptibility to @entity943 was @entity308 and @entity583 @entity35 , and @entity905 may reduce the incidence of @entity943 in @entity583 @entity35 and thus improve the prognosis. This may be related in part to the upregulation of @entity26739 by @entity905 .

title: Effect and mechanism of @entity905 on electrophysiology in vivo in a @entity35 model of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'increased in depression', 'depressive symptoms', 'depression']

entities_list: @entity905 :: ('MESH:D005473', 'Chemical') :: ['fluoxetine', 'Fluoxetine']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rats', 'rats']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['post-MI depression', 'myocardial infarction', 'MI']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmia', 'ventricular arrhythmias']

answer: @entity308 :: (MESH:D003866,Disease) :: ['postmyocardial infarction depression']


abstract: BACKGROUND: Major @entity308 is diagnosed in 18% of @entity1 following @entity583 ( @entity583 ), and the antidepressant @entity905 is shown to effectively decrease @entity308 and improve @entity301 prognosis. We observed the effect of @entity905 on cardiac electrophysiology in vivo in a @entity35 model of @entity583 and the potential mechanism. METHODS AND RESULTS: Eighty adult male @entity35 (200-250 g) were randomly assigned to five groups: normal control (control group), @entity583 ( @entity583 group), @entity308 ( @entity308 group), @entity583 (model group), and @entity583 treated with intragastric administration of 10 mg/kg @entity905 ( @entity905 group). @entity583 was induced by left anterior descending coronary artery ligation. @entity308 was developed by 4-week chronic mild stress (CMS). Behavior measurement was done before and during the experiment. Electrophysiology study in vivo and Western blot analysis were carried on after 4 weeks of CMS. After 4 weeks of CMS, @entity308 -like behaviors were observed in the @entity583 , @entity308 , and model groups, and chronic @entity905 administration could significantly improve those behaviors (P<0.05 vs model group). @entity905 significantly increased the @entity2224 threshold compared with the model group (20.20  9.32 V vs 14.67  1.85 V, P<0.05). Expression of @entity26739 was significantly reduced by 29%  12%, 24%  6%, and 41%  15%, respectively, in the @entity583 group, CMS group, and model group, which could be improved by @entity905 (30%  9%). But @entity905 showed no improvement on the @entity583 -induced loss of @entity10277 . CONCLUSION: The susceptibility to @entity943 was @entity308 and @entity583 @entity35 , and @entity905 may reduce the incidence of @entity943 in @entity583 @entity35 and thus improve the prognosis. This may be related in part to the upregulation of @entity26739 by @entity905 .

title: Effect and mechanism of XXXX on electrophysiology in vivo in a @entity35 model of @entity308 .

answer: @entity905 :: (MESH:D005473,Chemical) :: ['fluoxetine']


abstract: BACKGROUND: Major @entity308 is diagnosed in 18% of @entity1 following @entity583 ( @entity583 ), and the antidepressant @entity905 is shown to effectively decrease @entity308 and improve @entity301 prognosis. We observed the effect of @entity905 on cardiac electrophysiology in vivo in a @entity35 model of @entity583 and the potential mechanism. METHODS AND RESULTS: Eighty adult male @entity35 (200-250 g) were randomly assigned to five groups: normal control (control group), @entity583 ( @entity583 group), @entity308 ( @entity308 group), @entity583 (model group), and @entity583 treated with intragastric administration of 10 mg/kg @entity905 ( @entity905 group). @entity583 was induced by left anterior descending coronary artery ligation. @entity308 was developed by 4-week chronic mild stress (CMS). Behavior measurement was done before and during the experiment. Electrophysiology study in vivo and Western blot analysis were carried on after 4 weeks of CMS. After 4 weeks of CMS, @entity308 -like behaviors were observed in the @entity583 , @entity308 , and model groups, and chronic @entity905 administration could significantly improve those behaviors (P<0.05 vs model group). @entity905 significantly increased the @entity2224 threshold compared with the model group (20.20  9.32 V vs 14.67  1.85 V, P<0.05). Expression of @entity26739 was significantly reduced by 29%  12%, 24%  6%, and 41%  15%, respectively, in the @entity583 group, CMS group, and model group, which could be improved by @entity905 (30%  9%). But @entity905 showed no improvement on the @entity583 -induced loss of @entity10277 . CONCLUSION: The susceptibility to @entity943 was @entity308 and @entity583 @entity35 , and @entity905 may reduce the incidence of @entity943 in @entity583 @entity35 and thus improve the prognosis. This may be related in part to the upregulation of @entity26739 by @entity905 .

title: Effect and mechanism of @entity905 on electrophysiology in vivo in a XXXX model of @entity308 .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: The hyperinflammation that begins with @entity295 is essential for eradicating @entity281 but also causes hypoperfusion and organ failure. To understand the innate immune status of septic @entity1 , the functional and phenotypic changes of neutrophils during @entity295 and their clinical implication were studied. METHODS: Seventy-four @entity1 who were admitted to intensive care unit due to severe @entity295 or @entity326 were enrolled. Surface antigens of neutrophils ( @entity10685 , @entity2282 , and @entity4071 ) were detected by flow cytometry. Respiratory burst activity (RBA) was measured by flow cytometry using @entity21184 and @entity1359 . The parameters were serially examined at Days 1 and 8 in @entity326 @entity1 . RESULTS: High @entity10685 and low @entity2282 and @entity4071 on Day 1 was associated with @entity295 severity (P   =   0.003, 0.017, and 0.007, respectively). On Day 1, RBA and @entity10685 were higher in survivors than in nonsurvivors of @entity326 @entity1 (P   =   0.012 and 0.027, respectively), and on Day 8, @entity2282 and @entity4071 were higher in survivors than in nonsurvivors (P   =   0.019 and 0.036, respectively). High RBA and high @entity10685 on Day 1 showed low 28-day mortality in univariate analysis (P   =   0.018 and 0.034, respectively). In multivariate analysis, RBA maintained statistical significance (P   =   0.042) but @entity10685 revealed only a tendency (P   =   0.064). CONCLUSIONS: Neutrophil surface antigen ( @entity10685 , @entity2282 , and @entity4071 ) could reflect @entity295 severity. High @entity10685 expression and high RBA at early phase of @entity295 might be associated with better prognosis, whereas high expression of @entity2282 and @entity4071 at late phase of @entity295 might be associated with better prognosis.    2015 International Clinical Cytometry Society.

title: Flow cytometric measurement of respiratory burst activity and surface expression of neutrophils for septic XXXX prognosis.

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock']

entities_list: @entity1359 :: ('CHEBI:37537', 'Chemical') :: ['phorbol-12-myristate-13-acetate']

entities_list: @entity21184 :: ('MESH:C029569', 'Chemical') :: ["2',7'-dichlorofluorescein diacetate"]

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: UNASSIGNED: Although a complete thoracic spinal cord section in various mammals induces paralysis of @entity717 , the spinal lumbosacral circuitry below the lesion retains its ability to generate hindlimb locomotion. This important capacity may contribute to the overall locomotor recovery after partial @entity1566 ( @entity1566 ). In @entity35 , it is usually triggered by pharmacological and/or electrical stimulation of the cord while a robot sustains the animals in an upright posture. In the present study we daily trained a group of adult spinal (T7) @entity35 to walk with the hindlimbs for 10 wk (10 min/day for 5 days/wk), using only perineal stimulation. Kinematic analysis and terminal electromyographic recordings revealed a strong effect of training on the reexpression of hindlimb locomotion. Indeed, trained animals gradually improved their locomotion while untrained animals worsened throughout the post- @entity1566 period. Kinematic parameters such as averaged and instant swing phase velocity, step cycle variability, foot drag duration, off period duration, and relationship between the swing features returned to normal values only in trained animals. The present results clearly demonstrate that treadmill training alone, in a normal horizontal posture, elicited by noninvasive perineal stimulation is sufficient to induce a persistent hindlimb locomotor recovery without the need for more complex strategies. This provides a baseline level that should be clearly surpassed if additional locomotor-enabling procedures are added. Moreover, it has a clinical value since intrinsic spinal reorganization induced by training should contribute to improve locomotor recovery together with afferent feedback and supraspinal modifications in @entity1 with incomplete @entity1566 .

title: Inducing hindlimb locomotor recovery in adult XXXX after complete thoracic spinal cord section using repeated treadmill training with perineal stimulation only.

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['voluntary movements']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: AIM OF THE STUDY: @entity85 are relatively rare, and their geographic distribution varies greatly around the world. In this study, we present the incidence, age distribution and localization of @entity85 diagnosed and/or treated at a tertiary referral orthopedic department, catering to an entire Southeastern European country. METHODS: This was a retrospective study of prospectively collected data, in which all @entity1 diagnosed and/or treated for @entity85 at our Department in the period of 30 years (1981-2010) were included. RESULTS: Data of a total of 3482 @entity1 with @entity85 were collected. Average age of @entity1 was 33.5 years (range, 2 months-88 years), with even distribution according to sex. @entity5 were seen in 20.7% of @entity1 , more often in @entity1 (56.9%). Most common @entity5 were @entity421 (estimated incidence: 1.68/million/year), @entity511 (0.79/million/year) and @entity2828 (0.76/million/year). @entity5 and @entity5 -like lesions were found in 79.3% of @entity1 , with slight female predominance. Most common @entity79 were @entity705 (5.81/million/year), simple bone cyst (2.13/million/year), and @entity83 (2.05/million/year). CONCLUSION: This report represents a first of its kind in our region, and gives representative results to be compared to other middle and south European countries. Further nationwide studies are needed to improve strategies in @entity3478 diagnosis and treatment.

title: Epidemiology of XXXX in a national referral orthopedic department. A study of 3482 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma']

entities_list: @entity511 :: ('MESH:D002813', 'Disease') :: ['chondrosarcoma']

entities_list: @entity3478 :: ('MESH:D001859', 'Disease') :: ['bone tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Benign tumors', 'malignant tumors', 'Malignant tumors']

entities_list: @entity705 :: ('MESH:D015831', 'Disease') :: ['osteochondroma']

entities_list: @entity83 :: ('MESH:D002812', 'Disease') :: ['enchondroma']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['benign bone lesions']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal tumors', 'Musculoskeletal tumors']

answer: @entity85 :: (MESH:D009140,Disease) :: ['musculoskeletal tumors']


abstract: PURPOSE: To describe the efficacy of combined excimer laser photoablation and amniotic overlay membrane in the relief of symptomatic discomfort in a 17-year-old @entity1 who had @entity14671 . METHODS: The best-corrected visual acuity (BCVA) was measured with Snellen letters. Slit-lamp examination of the ocular surface and anterior chamber was performed at baseline. Results were photodocumented. Excimer laser photoablation was performed and subsequently 2 amniotic membranes were transconjunctivally fixated with 10.0 nylon sutures. Investigations and documentation were performed at baseline, every 2 months in the first year, and then every 6 months. The duration of follow-up was 22 months. RESULTS: At baseline, the BCVA was 20/70 in the right eye and 20/200 in the left eye. The @entity1 reported distinct @entity3917 . Slit-lamp examination was difficult because of @entity9663 . Although gelatinous drops developed again and the BCVA decreased to 2/200, the @entity1 reported significant relief after both microsurgical treatments and remained comfortable at 20 and 22 months. CONCLUSIONS: Excimer laser photocoagulation combined with amniotic membrane overlay does not stop the development of @entity14671 but may improve subjective comfort. Such treatment does not hinder subsequent lamellar or penetrating grafts and is helpful in providing the necessary time for preparation of matched keratoplasties.

title: Combined Excimer Laser Photoablation and Amniotic Membrane Overlay for Relief of Symptomatic Discomfort in XXXX .

entities_list: @entity14671 :: ('MESH:C535480', 'Disease') :: ['gelatinous drop-like corneal dystrophy']

entities_list: @entity3917 :: ('MESH:D020795', 'Disease') :: ['photophobia']

entities_list: @entity9663 :: ('MESH:D001764', 'Disease') :: ['blepharospasm']

answer: @entity14671 :: (MESH:C535480,Disease) :: ['Gelatinous Drop-like Corneal Dystrophy']


abstract: The aim of this research was to examine the mediating roles played by a range of biographic and illness-related factors in preferences for strategies for coping with @entity102 . @entity102 @entity1 assessed their own coping strategy preference by ranking six clusters of strategies. Information was also obtained about their demographic characteristics, life styles, illness roles, the degree of their disability, their perceived handicaps and their perceived achievement of their rehabilitation goals. Multiple regression analyses of each of these six sets of variables on each coping strategy were carried out to identify patterns of association between them. (1) Preferences for action strategies were found to be associated with @entity1 -related factors (demographic characteristics, life style and illness role). (2) Control strategies were associated with illness-related factors (illness role, degree of disability, perceived handicap and achievement of rehabilitation goals). (3) Escape strategies were ranked higher by @entity1 than by @entity1 , sex being their only significant predictor. (4) Preferences for @entity3329 , unlike those for action strategies, were associated with relatively low social status and relatively little interpersonal involvement or social commitment. (5) Preferences for optimism were related only to @entity1 ' perceptions of their handicaps. (6) Interpersonal coping was not found to be associated with any of this wide range of biographic illness-related factors.

title: Coping with XXXX : the mediating role of biographic and illness-related factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic illness', 'Chronically-ill']

answer: @entity102 :: (MESH:D002908,Disease) :: ['chronic illness']


abstract: Background: There is a need for improved clinical identification of hospitalized @entity1 at risk of @entity1173 . We evaluated our novel phonetic test in a broad spectrum of intensive or intermediate care unit @entity1 at risk for @entity1173 . Methods: We prospectively enrolled 60 hospitalized @entity1 with @entity1173 risk, between December 2009 and September 2011, who subsequently underwent audio-recorded 3-component phonetic bedside evaluation. The recordings were scored by two blinded speech-language pathologists. The institutional " @entity1282 Admission Screening Test" was performed by a bedside nurse. The primary outcomes, @entity1282 and @entity1173 , were assessed by videofluoroscopic swallowing study and/or fiberoptic endoscopic evaluation of swallowing. We assessed the short and long-term clinical outcomes (length of stay, subsequent @entity1174 and @entity1576 , survival), and how these associated with the phonetic and swallow assessments. Results: Statistically significant linear associations with @entity1282 were noted for all three individual phonetic components. Also, there were statistically significant linear associations with @entity1173 for diadochokinesis (P=0.050) and Consensus Auditory-Perceptual Evaluation of voice (P=0.025). Diadochokinesis alone predicted @entity1282 (AUC: 0.74, P=0.001) and @entity1173 (AUC: 0.67, P=0.012). Its predictive ability improved when combined with normalized @entity1282 admission screening test results (AUC: 0.79, P=0.001). The short and long-term clinical outcomes were adversely affected by the worse phonetic/swallowing scores, though not statistically different. Conclusions: Abnormal phonation among intensive and intermediate care unit @entity1 is associated with @entity1282 and @entity1173 . Future investigative efforts should uncover the most effective combination of evaluations for accurate bedside detection of @entity1282 and @entity1173 risk in a broad spectrum of @entity1 .

title: Novel Bedside Phonetic Evaluation to Identify XXXX and Aspiration Risk.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1174 :: ('MESH:D011015', 'Disease') :: ['aspiration pneumonia']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['Dysphagia', 'dysphagia']

entities_list: @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspiration']

answer: @entity1282 :: (MESH:D003680,Disease) :: ['Dysphagia']


abstract: BACKGROUND: @entity177 ( @entity177 ) remains a significant problem in limited @entity151 (LD- @entity4153 ) @entity1 treated with definitive chemoradiotherapy. Dose-escalation may be a way forward to reduce the failure rate. However, the risk of @entity137 rises with increasing doses. Knowledge on factors associated with @entity177 could aid the selection of @entity1 for more aggressive treatment. Therefore, the aim of this study is to evaluate factors correlated with @entity177 in a cohort of LD- @entity4153 @entity1 treated with definitive chemoradiotherapy. Moreover, factors associated with improved survival were investigated. MATERIAL AND METHODS: We included 147 consecutive LD- @entity4153 @entity1 treated from 2007 to 2013. Radiotherapy was delivered as either 45 Gy in 1.5-Gy fractions twice daily or 46-50 Gy in 2-Gy fractions once daily. Chemotherapy was @entity2879 combined with either @entity3003 or @entity900 given mainly concomitantly with radiotherapy. Pattern of first failure and survival were evaluated retrospectively. @entity7184 ( @entity7184 ) and @entity1349 ( @entity1349 ) were calculated by the Kaplan-Meier method. The impact of covariates on @entity177 and @entity1349 was evaluated by using Cox proportional hazards model. RESULTS: With a median follow-up time of 42.2 months, 37 @entity1 experienced @entity177 as first failure. Isolated @entity177 was seen in 16 @entity1 , but no isolated regional failure was seen. The @entity7184 rate was 22% at 1-year and 43% at 3-years. N3-stage was an independent prognostic factor correlated with @entity177 development (p = 0.043). Median @entity1349 was 24.1 months (95% CI 19-29 months) and a three-year survival of 34%. Prognostic factors associated with improved @entity1349 were staging including a positron emission tomography (PET) scan (p = 0.004) and receiving prophylactic cranial irradiation (PCI) (p = 0.006). CONCLUSION: N3-stage was an independent prognostic factor for @entity177 . Receiving a pretreatment PET scan and receiving PCI were prognostic factors for improved @entity1349 . Reduction in @entity177 may be achieved with dose-escalation in @entity1 with N3-stage. This can be evaluated in prospective dose-escalation trials.

title: Evaluation of factors associated with loco-regional failure and survival in limited XXXX @entity1 treated with chemoradiotherapy.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity7184 :: ('MESH:D012090', 'Disease') :: ['Cumulative LRF', 'CLRF']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['Loco-regional failure', 'LRF']

entities_list: @entity151 :: ('MESH:D055752', 'Disease') :: ['disease small cell lung cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity151 :: (MESH:D055752,Disease) :: ['disease small cell lung cancer']


abstract: BACKGROUND: @entity177 ( @entity177 ) remains a significant problem in limited @entity151 (LD- @entity4153 ) @entity1 treated with definitive chemoradiotherapy. Dose-escalation may be a way forward to reduce the failure rate. However, the risk of @entity137 rises with increasing doses. Knowledge on factors associated with @entity177 could aid the selection of @entity1 for more aggressive treatment. Therefore, the aim of this study is to evaluate factors correlated with @entity177 in a cohort of LD- @entity4153 @entity1 treated with definitive chemoradiotherapy. Moreover, factors associated with improved survival were investigated. MATERIAL AND METHODS: We included 147 consecutive LD- @entity4153 @entity1 treated from 2007 to 2013. Radiotherapy was delivered as either 45 Gy in 1.5-Gy fractions twice daily or 46-50 Gy in 2-Gy fractions once daily. Chemotherapy was @entity2879 combined with either @entity3003 or @entity900 given mainly concomitantly with radiotherapy. Pattern of first failure and survival were evaluated retrospectively. @entity7184 ( @entity7184 ) and @entity1349 ( @entity1349 ) were calculated by the Kaplan-Meier method. The impact of covariates on @entity177 and @entity1349 was evaluated by using Cox proportional hazards model. RESULTS: With a median follow-up time of 42.2 months, 37 @entity1 experienced @entity177 as first failure. Isolated @entity177 was seen in 16 @entity1 , but no isolated regional failure was seen. The @entity7184 rate was 22% at 1-year and 43% at 3-years. N3-stage was an independent prognostic factor correlated with @entity177 development (p = 0.043). Median @entity1349 was 24.1 months (95% CI 19-29 months) and a three-year survival of 34%. Prognostic factors associated with improved @entity1349 were staging including a positron emission tomography (PET) scan (p = 0.004) and receiving prophylactic cranial irradiation (PCI) (p = 0.006). CONCLUSION: N3-stage was an independent prognostic factor for @entity177 . Receiving a pretreatment PET scan and receiving PCI were prognostic factors for improved @entity1349 . Reduction in @entity177 may be achieved with dose-escalation in @entity1 with N3-stage. This can be evaluated in prospective dose-escalation trials.

title: Evaluation of factors associated with loco-regional failure and survival in limited @entity151 XXXX treated with chemoradiotherapy.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Whether a coronary artery @entity460 (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department @entity1 with acute @entity662 remains unsettled. We sought to determine the value of CAC scan in @entity1 with acute @entity662 undergoing CCTA. METHODS AND RESULTS: In the multicenter Rule Out Myocardial Infarction using Computer-Assisted Tomography (ROMICAT) II trial, we enrolled low-intermediate risk emergency department @entity1 with symptoms suggesting @entity1187 ( @entity1187 ). In this prespecified subanalysis of 473 @entity1 (54  8 years, 53% @entity1 ) who underwent both CAC scanning and CCTA, the @entity1187 rate was 8%. Overall, 53% of @entity1 had CAC=0 of whom 2 (0.8%) developed @entity1187 , whereas 7% had CAC>400 with 49% whom developed @entity1187 . C-statistic of CAC>0 was 0.76, whereas that using the optimal cut point of CAC>= 22 was 0.81. Continuous CAC score had lower discriminatory capacity than CCTA (c-statistic, 0.86 versus 0.92; P=0.03). Compared with CCTA alone, there was no benefit combining CAC score with CCTA (c-statistic, 0.93; P=0.88) or with selective CCTA strategies after initial CAC>0 or optimal cut point CAC>= 22 (P>= 0.09). Mean radiation dose from CAC acquisition was 1.4  0.7 @entity2073 . Higher CAC scores resulted in more nondiagnostic CCTA studies although the majority remained interpretable. CONCLUSIONS: In emergency department @entity1 with acute @entity662 , CAC score does not provide incremental value beyond CCTA for @entity1187 diagnosis. CAC=0 does not exclude @entity1187 , nor a high CAC score preclude interpretation of CCTA in most @entity1 . Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01084239.

title: Use of Coronary Artery XXXX Scanning Beyond Coronary Computed Tomographic Angiography in the Emergency Department Evaluation for Acute @entity662 : The ROMICAT II Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['Calcium']


abstract: BACKGROUND: Whether a coronary artery @entity460 (CAC) scan provides added value to coronary computed tomographic angiography (CCTA) in emergency department @entity1 with acute @entity662 remains unsettled. We sought to determine the value of CAC scan in @entity1 with acute @entity662 undergoing CCTA. METHODS AND RESULTS: In the multicenter Rule Out Myocardial Infarction using Computer-Assisted Tomography (ROMICAT) II trial, we enrolled low-intermediate risk emergency department @entity1 with symptoms suggesting @entity1187 ( @entity1187 ). In this prespecified subanalysis of 473 @entity1 (54  8 years, 53% @entity1 ) who underwent both CAC scanning and CCTA, the @entity1187 rate was 8%. Overall, 53% of @entity1 had CAC=0 of whom 2 (0.8%) developed @entity1187 , whereas 7% had CAC>400 with 49% whom developed @entity1187 . C-statistic of CAC>0 was 0.76, whereas that using the optimal cut point of CAC>= 22 was 0.81. Continuous CAC score had lower discriminatory capacity than CCTA (c-statistic, 0.86 versus 0.92; P=0.03). Compared with CCTA alone, there was no benefit combining CAC score with CCTA (c-statistic, 0.93; P=0.88) or with selective CCTA strategies after initial CAC>0 or optimal cut point CAC>= 22 (P>= 0.09). Mean radiation dose from CAC acquisition was 1.4  0.7 @entity2073 . Higher CAC scores resulted in more nondiagnostic CCTA studies although the majority remained interpretable. CONCLUSIONS: In emergency department @entity1 with acute @entity662 , CAC score does not provide incremental value beyond CCTA for @entity1187 diagnosis. CAC=0 does not exclude @entity1187 , nor a high CAC score preclude interpretation of CCTA in most @entity1 . Thus, CAC results should not influence the decision to proceed with CCTA, and the decision to perform a CAC scan should be balanced with the additional radiation exposure required. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT01084239.

title: Use of Coronary Artery @entity460 Scanning Beyond Coronary Computed Tomographic Angiography in the Emergency Department Evaluation for Acute XXXX : The ROMICAT II Trial.

answer: @entity662 :: (MESH:D002637,Disease) :: ['Chest Pain']


abstract: PURPOSE OF THE REPORT: @entity1419 's incidence is increasing. We studied the efficacy of Y selective internal radiation therapy (SIRT) as first-line treatment, with chemotherapy, and compared with the results of chemotherapy alone. @entity1 AND METHODS: We retrospectively studied data from @entity1 treated at our institution with glass microspheres SIRT for @entity1419 as part of first-line treatment in combination with chemotherapy. We compared results with those of similar @entity1 treated in the ABC-02 study (a study in advanced @entity1125 that defined the current standard chemotherapy), assessed as not progressing after the first evaluation. We assessed progression-free survival (PFS) and overall survival (OS). RESULTS: Twenty-four @entity1 were treated with SIRT. Chemotherapy was given concomitantly in 10 (42%), as induction before SIRT in 13 (54%) or after SIRT in 1 (4%). Grade 3 adverse events were reported in 1 (4%). Median PFS after SIRT was 10.3 months. Longer PFS was observed when chemotherapy was given concomitantly than when chemotherapy was given before SIRT, with respective median of 20.0 versus 8.8 months (P = 0.001). Median OS after SIRT was not reached. Eleven @entity1 went to surgery (46%). Thirty-three @entity1 in ABC-02 had locally advanced nonextrahepatic @entity201 , not progressing after first evaluation. From the start of any treatment, the median PFS was 16.0 months in our cohort versus 11.3 months in ABC-02 (P = 0.25), whereas the median OS was significantly higher in our cohort, not reached versus 17.9 months, respectively (P = 0.026). CONCLUSIONS: Selective internal radiation therapy combined with concomitant chemotherapy seems a promising strategy as first-line treatment for unresectable @entity1419 .

title: Glass Microspheres 90Y Selective Internal Radiation Therapy and Chemotherapy as First-Line Treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma']

entities_list: @entity1419 :: ('MESH:C535533', 'Disease') :: ['Intrahepatic cholangiocarcinoma', 'intrahepatic cholangiocarcinoma']

entities_list: @entity1125 :: ('MESH:D001661', 'Disease') :: ['biliary tract cancer']

answer: @entity1419 :: (MESH:C535533,Disease) :: ['Intrahepatic Cholangiocarcinoma']


abstract: UNASSIGNED: The @entity1573 chorioallantoic membrane (CAM) model has been successfully used to study angiogenesis, @entity5 progression and its pharmacological treatment, @entity5 pharmacokinetics, and properties of novel nanomaterials. MRI is an attractive technique for non-invasive and longitudinal monitoring of physiological processes and @entity5 growth. This study proposes an age-adapted cooling regime for immobilization of the @entity1573 embryo, enabling high-resolution MRI of the embryo and the @entity5 xenograft. 64 @entity1573 embryos were enrolled in this study. The novel immobilization and imaging protocol was optimized in 29 embryos. From d7 to d18 immobilization of the embryo up to 90   min was achieved by cooling at 4     C pre-imaging, with cooling times adapted to age. Its application to @entity5 growth monitoring was evaluated in 15 embryos after xenotransplantation of @entity1 MDA-MB-231 @entity0 cells on CAM. @entity5 volumes were monitored from d4 to d9 after grafting (d11 to d16 after incubation) applying a T2 -weighted multislice RARE sequence. At d9 after grafting, the @entity5 were collected and compared with the MRI-derived data by histology and weight measurements. Additional imaging methods comprising DWI, T2 mapping, and the bio-distribution of contrast agents were tested at d9 after grafting in 20 further embryos. With the adaptive cooling regime, motion artifacts could be completely avoided for up to 90   min scan time, enabling high-resolution in ovo imaging. Excellent anatomical details could be obtained in the embryo and @entity5 . @entity5 volumes could be quantified over time. The results prove the feasibility of high-resolution MRI for @entity5 and organ growth monitoring. The suggested method is promising for future applications such as testing tailored and/or targeted treatment strategies, longitudinal monitoring of @entity5 development, analysis of therapeutic efficacies of drugs, or assessment of @entity5 pharmacokinetics. The method provides an alternative to animal experimentation. Copyright    2015 John Wiley _ Sons, Ltd.

title: High-resolution MRI analysis of XXXX xenograft on the @entity1573 chorioallantoic membrane.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'CAM tumor', 'cancer', 'Tumor', 'longitudinal tumor', 'tumors']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: UNASSIGNED: The @entity1573 chorioallantoic membrane (CAM) model has been successfully used to study angiogenesis, @entity5 progression and its pharmacological treatment, @entity5 pharmacokinetics, and properties of novel nanomaterials. MRI is an attractive technique for non-invasive and longitudinal monitoring of physiological processes and @entity5 growth. This study proposes an age-adapted cooling regime for immobilization of the @entity1573 embryo, enabling high-resolution MRI of the embryo and the @entity5 xenograft. 64 @entity1573 embryos were enrolled in this study. The novel immobilization and imaging protocol was optimized in 29 embryos. From d7 to d18 immobilization of the embryo up to 90   min was achieved by cooling at 4     C pre-imaging, with cooling times adapted to age. Its application to @entity5 growth monitoring was evaluated in 15 embryos after xenotransplantation of @entity1 MDA-MB-231 @entity0 cells on CAM. @entity5 volumes were monitored from d4 to d9 after grafting (d11 to d16 after incubation) applying a T2 -weighted multislice RARE sequence. At d9 after grafting, the @entity5 were collected and compared with the MRI-derived data by histology and weight measurements. Additional imaging methods comprising DWI, T2 mapping, and the bio-distribution of contrast agents were tested at d9 after grafting in 20 further embryos. With the adaptive cooling regime, motion artifacts could be completely avoided for up to 90   min scan time, enabling high-resolution in ovo imaging. Excellent anatomical details could be obtained in the embryo and @entity5 . @entity5 volumes could be quantified over time. The results prove the feasibility of high-resolution MRI for @entity5 and organ growth monitoring. The suggested method is promising for future applications such as testing tailored and/or targeted treatment strategies, longitudinal monitoring of @entity5 development, analysis of therapeutic efficacies of drugs, or assessment of @entity5 pharmacokinetics. The method provides an alternative to animal experimentation. Copyright    2015 John Wiley _ Sons, Ltd.

title: High-resolution MRI analysis of @entity0 xenograft on the XXXX chorioallantoic membrane.

answer: @entity1573 :: (9031,Species) :: ['chick']


abstract: PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the continuous heating and circulation of chemotherapy throughout the abdominal cavity in an attempt to enhance @entity137 . Despite the potential of this chemotherapy procedure, there are scant anatomical temperature distribution studies reporting on this therapeutic process. @entity1 AND METHODS: We prospectively evaluated the temperature of select anatomical (e.g. upper abdominal, mid-abdominal and supra-pubic) sites in 11 advanced stage @entity43 @entity1 who were treated with consolidation HIPEC @entity3003 (AUC 10). The temperature of the aforementioned anatomical regions and the inflow/outflow tubing was measured at baseline and at 15-min intervals until the procedure's completion. RESULTS: The lowest observed mean composite temperature was 41.1     C at the supra-pubic site whereas the highest temperature was 42.6     C, in association with the inflow/outflow tubing. During the various time intervals we also ascertained that the lowest composite temperature was 40.9     C at baseline (i.e. time 0), whereas the highest value (41.8     C) occurred at multiple time periods (e.g. 15, 45 and 60   min). CONCLUSION: The HIPEC temperature variation amongst the various abdominal sites and time intervals was minimal. We also discerned that uniform temperature distribution throughout the abdominal cavity was facilitated when the abdomen was both maximally distended with fluid and a high flow rate was maintained.

title: Intra-abdominal temperature distribution during consolidation hyperthermic intraperitoneal chemotherapy with XXXX in the treatment of @entity43 .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

answer: @entity3003 :: (MESH:D016190,Chemical) :: ['carboplatin']


abstract: PURPOSE: Hyperthermic intraperitoneal chemotherapy (HIPEC) involves the continuous heating and circulation of chemotherapy throughout the abdominal cavity in an attempt to enhance @entity137 . Despite the potential of this chemotherapy procedure, there are scant anatomical temperature distribution studies reporting on this therapeutic process. @entity1 AND METHODS: We prospectively evaluated the temperature of select anatomical (e.g. upper abdominal, mid-abdominal and supra-pubic) sites in 11 advanced stage @entity43 @entity1 who were treated with consolidation HIPEC @entity3003 (AUC 10). The temperature of the aforementioned anatomical regions and the inflow/outflow tubing was measured at baseline and at 15-min intervals until the procedure's completion. RESULTS: The lowest observed mean composite temperature was 41.1     C at the supra-pubic site whereas the highest temperature was 42.6     C, in association with the inflow/outflow tubing. During the various time intervals we also ascertained that the lowest composite temperature was 40.9     C at baseline (i.e. time 0), whereas the highest value (41.8     C) occurred at multiple time periods (e.g. 15, 45 and 60   min). CONCLUSION: The HIPEC temperature variation amongst the various abdominal sites and time intervals was minimal. We also discerned that uniform temperature distribution throughout the abdominal cavity was facilitated when the abdomen was both maximally distended with fluid and a high flow rate was maintained.

title: Intra-abdominal temperature distribution during consolidation hyperthermic intraperitoneal chemotherapy with @entity3003 in the treatment of XXXX .

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

answer: @entity43 :: (MESH:D010051,Disease) :: ['advanced stage ovarian carcinoma']


abstract: UNASSIGNED: Mild @entity75 with a reversible @entity75 ( @entity7822 ) is a clinico-radiological syndrome characterized by a transient mild @entity75 and a reversible lesion in the splenium of the corpus callosum on MRI. This syndrome has almost universally been described in @entity1 from Japan and East Asia. Here we describe seven cases of @entity7822 occurring in Caucasian Australian @entity1 from one centre seen over a 3 year period. All @entity1 had a fever-associated @entity75 (n  =  7), which presented with @entity911 (n  =  4), @entity146 (n  =  3), lethargy (n  =  3), slurred speech (n  =  3), drowsiness (n  =  2) and @entity1833 (n  =  2). Other @entity16 included @entity2055 (n  =  5) and @entity410 (n  =  1). These symptoms resolved rapidly over 4-6 days followed by complete neurological recovery. In all @entity1 , MRI performed within 1-3 days of onset of @entity75 demonstrated a symmetrical diffusion-restricted lesion in the splenium of the corpus callosum. Three @entity1 had additional lesions involving other parts of the corpus callosum and adjacent periventricular white matter. These same three @entity1 had mild persisting white matter changes evident at followup MRI, while the other @entity1 had complete resolution of radiological changes. A potential trigger was present in five of the seven cases: @entity573 , @entity5746 , @entity2803 , influenza B and adenovirus (all n  =  1). Elevated white cell count (n  =  4), elevated @entity1851 (n  =  5) and @entity2753 (n  =  6) were commonly observed. CSF was performed in four @entity1 , which showed no pleocytosis. This case series of @entity7822 demonstrates this condition occurs outside of East Asia and is an important differential to consider in @entity1 presenting with acute @entity75 .

title: Mild @entity75 with reversible XXXX : An important differential of encephalitis.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity2803 :: ('MESH:D003586', 'Disease') :: ['cytomegalovirus']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity573 :: ('MESH:C537014', 'Disease') :: ['Kawasaki disease']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['irritability']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['splenial lesion', 'encephalopathy']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms']

entities_list: @entity1833 :: ('MESH:D006212', 'Disease') :: ['hallucinations']

entities_list: @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion']

entities_list: @entity5746 :: ('MESH:D012480', 'Disease') :: ['Salmonella']

entities_list: @entity2753 :: ('MESH:D007010', 'Disease') :: ['hyponatremia']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C reactive protein']

answer: @entity75 :: (MESH:D001927,Disease) :: ['splenial lesion']


abstract: UNASSIGNED: Mild @entity75 with a reversible @entity75 ( @entity7822 ) is a clinico-radiological syndrome characterized by a transient mild @entity75 and a reversible lesion in the splenium of the corpus callosum on MRI. This syndrome has almost universally been described in @entity1 from Japan and East Asia. Here we describe seven cases of @entity7822 occurring in Caucasian Australian @entity1 from one centre seen over a 3 year period. All @entity1 had a fever-associated @entity75 (n  =  7), which presented with @entity911 (n  =  4), @entity146 (n  =  3), lethargy (n  =  3), slurred speech (n  =  3), drowsiness (n  =  2) and @entity1833 (n  =  2). Other @entity16 included @entity2055 (n  =  5) and @entity410 (n  =  1). These symptoms resolved rapidly over 4-6 days followed by complete neurological recovery. In all @entity1 , MRI performed within 1-3 days of onset of @entity75 demonstrated a symmetrical diffusion-restricted lesion in the splenium of the corpus callosum. Three @entity1 had additional lesions involving other parts of the corpus callosum and adjacent periventricular white matter. These same three @entity1 had mild persisting white matter changes evident at followup MRI, while the other @entity1 had complete resolution of radiological changes. A potential trigger was present in five of the seven cases: @entity573 , @entity5746 , @entity2803 , influenza B and adenovirus (all n  =  1). Elevated white cell count (n  =  4), elevated @entity1851 (n  =  5) and @entity2753 (n  =  6) were commonly observed. CSF was performed in four @entity1 , which showed no pleocytosis. This case series of @entity7822 demonstrates this condition occurs outside of East Asia and is an important differential to consider in @entity1 presenting with acute @entity75 .

title: Mild XXXX with reversible @entity75 : An important differential of encephalitis.

answer: @entity75 :: (MESH:D001927,Disease) :: ['encephalopathy']


abstract: INTRODUCTION: Rupture of the ventricular septum complicates @entity583 in 0.2% of cases in the thrombolytic era. @entity1757 ( @entity1757 ) has a mortality of 90-95% in medically managed and 19-60% in surgically treated @entity1 . METHODS: A retrospective analysis was performed of 41 @entity1 , 26 females (63.4%) and 15 males (36.6%), average age 67.5    15 years, with post-infarction @entity1757 who were treated in the VUL SK intensive cardiology unit between 1991 and 2007. RESULTS: Thirty-seven @entity1 had @entity101 (90.2%); anterior wall @entity583 ( @entity583 ) was found in 27 @entity1 (68%). @entity1757 was more frequent in @entity1 than in @entity1 (p=0.043). In 36 @entity1 (87%) treatment was started 24 hours or later after the development of @entity583 symptoms. In 34 @entity1 (83%) the @entity397 occurred during the first episode of @entity583 and in the majority of these (19 @entity1 , 46.3%), preoperative coronary angiography demonstrated disease of only one coronary artery. During the first 10 days after the onset of @entity583 , 5 @entity1 (12.2%) were treated surgically but did not survive the operation; 33 @entity1 (80.5%) underwent operation 3-4 weeks after the onset of @entity583 and all survived. CONCLUSIONS: Female sex, advanced age, arterial @entity101 , anterior wall @entity583 , absence of previous @entity583 , and late arrival at hospital are associated with a higher risk of mortality from acute @entity1757 . The most important factor that determines operative mortality and intra-hospital survival is the time from the onset of @entity583 to operation.

title: Post-infarction XXXX : risk factors and early outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['Ventricular septal defect', 'VSD']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']

answer: @entity1757 :: (MESH:D006345,Disease) :: ['ventricular septal defect']


abstract: Diminished insulin sensitivity in the peripheral tissues and failure of pancreatic beta cells to secrete insulin are known major determinants of @entity6 . @entity71563 , an intestine-specific microsomal transfer protein inhibitor, has been shown to suppress high fat-induced @entity28 and ameliorate @entity13897 while enhancing @entity15212 ( @entity15212 ) secretion. We investigated the effects of @entity71563 on glucose metabolism and elucidated the mechanism of action, direct effects on insulin sensitivity and glucose-stimulated insulin secretion in a high fat diet-induced @entity28 @entity35 model. Male @entity35 fed a high-fat diet were treated with a single administration of @entity71563 . Glucose tolerance, @entity1602 clamp and hyperinsulinemic-euglycemic testing were performed to assess effects on insulin sensitivity and glucose-stimulated insulin secretion, respectively. Plasma @entity15212 and tissue triglyceride content were also determined under the same conditions. A single administration of @entity71563 suppressed plasma glucose elevations after oral glucose loading and increased the disposition index while elevating @entity15212 . @entity71563 also enhanced glucose-stimulated insulin secretion in @entity1602 clamp tests, whereas @entity1720 was observed in @entity1062 . Single-dose administration of @entity71563 decreased lipid content in the liver and skeletal muscle. @entity71563 demonstrated acute and direct hypoglycemic effects by enhancing insulin secretion and/or insulin sensitivity.

title: Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of  microsomal triglyceride transfer protein (MTP) in XXXX @entity35 .

entities_list: @entity13897 :: ('MESH:D018149', 'Disease') :: ['impaired glucose tolerance']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['type 2 diabetes mellitus']

entities_list: @entity1062 :: ('MESH:D013736', 'Disease') :: ['hyperinsulinemic-euglycemic clamp tests']

entities_list: @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague Dawley rats']

entities_list: @entity1720 :: ('MESH:D007333', 'Disease') :: ['increased insulin sensitivity']

entities_list: @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: Diminished insulin sensitivity in the peripheral tissues and failure of pancreatic beta cells to secrete insulin are known major determinants of @entity6 . @entity71563 , an intestine-specific microsomal transfer protein inhibitor, has been shown to suppress high fat-induced @entity28 and ameliorate @entity13897 while enhancing @entity15212 ( @entity15212 ) secretion. We investigated the effects of @entity71563 on glucose metabolism and elucidated the mechanism of action, direct effects on insulin sensitivity and glucose-stimulated insulin secretion in a high fat diet-induced @entity28 @entity35 model. Male @entity35 fed a high-fat diet were treated with a single administration of @entity71563 . Glucose tolerance, @entity1602 clamp and hyperinsulinemic-euglycemic testing were performed to assess effects on insulin sensitivity and glucose-stimulated insulin secretion, respectively. Plasma @entity15212 and tissue triglyceride content were also determined under the same conditions. A single administration of @entity71563 suppressed plasma glucose elevations after oral glucose loading and increased the disposition index while elevating @entity15212 . @entity71563 also enhanced glucose-stimulated insulin secretion in @entity1602 clamp tests, whereas @entity1720 was observed in @entity1062 . Single-dose administration of @entity71563 decreased lipid content in the liver and skeletal muscle. @entity71563 demonstrated acute and direct hypoglycemic effects by enhancing insulin secretion and/or insulin sensitivity.

title: Mechanism of action of hypoglycemic effects of an intestine-specific inhibitor of  microsomal triglyceride transfer protein (MTP) in @entity28 XXXX .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: AIM: Local excision of early @entity5 (ERCa) offers comparable survival and reduced operative morbidity compared with radical surgery yet it risks an adverse oncological outcome if performed in the wrong setting. This retrospective review considers the impact of the introduction of a specialist Early Rectal Cancer MDT (ERCaMDT) on the investigation and management of ERCa. METHOD: A retrospective comparative cohort study was undertaken. @entity1 with a final diagnosis of @entity2558 @entity5 at our unit were identified for two 12-month periods before and after the introduction of the specialist ERCaMDT. Data on investigations and therapeutic interventions were compared. RESULTS: Nineteen @entity1 from 2006 and 24 from 2011 were included. In 2006, 12 @entity1 underwent @entity2996 and four transrectal ultrasound (TRUS) examination while in 2011, 18 and 20 received @entity2996 ( @entity2996 ) and TRUS. In 2006 four @entity1 underwent incidental ERCa polypectomy with all having a positive resection margin leading to anterior resection. In 2011 only one case with a positive margin following extended EMR was identified. Definitive local excision without subsequent resection occurred in two @entity1 in 2006 and in 16 in 2011. CONCLUSION: The study demonstrates an improvement in pre-operative ERCa staging, a reduction in margin positivity and an increase in the use of local excision following the implementation of a specialist ERCa MDT. The increased detection of @entity188 through screening and surveillance programmes requires further investigation and management. A specialist ERCa MDT will improve management and should be available to all practioners involved with @entity1 with early @entity5 . This article is protected by copyright. All rights reserved.

title: The impact of a dedicated multidisciplinary team on the management of early XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer']

entities_list: @entity2996 :: ('MESH:C564543', 'Disease') :: ['MRI', 'magnetic resonance imaging']

entities_list: @entity188 :: ('MESH:D012004', 'Disease') :: ['rectal neoplasms']

answer: @entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']


abstract: UNASSIGNED: Although diagnosis is a central issue in medical care, in psychiatry its value is still controversial. The function of diagnosis is to indicate treatments and to help clinicians take better care of @entity1 . The fundamental role of diagnosis is to predict outcome and prognosis. To date serious concern persists regarding the clinical utility and predictive validity of the diagnosis system in psychiatry, which is at the most syndromal. @entity161 and @entity162 , which nosologists consider two distinct disorders, are the most discussed @entity146 illnesses. Recent findings in different fields of @entity146 research, such as neuroimaging, neuropathology, neuroimmunology, neuropsychology and genetics, have led to other conceptualizations. Individuals with @entity161 or @entity162 vary greatly with regard to symptoms, illness course, treatment response, @entity73 and biological correlates. In fact, it is possible to find heterogeneous correlates even within the same syndrome, i.e., from one stage of the disorder to another. Thus, it is possible to identify different subsyndromes, which share some clinical and neurobiological characteristics. The main goal of modern psychiatry is to ovethrow these barriers and to obtain a better understanding of the biological profiles underlying heterogeneous clinical features and thus reduce the variance and lead to a homogeneous definition. The translational research model, which connects the basic neuroscience research field with clinical experience in psychiatry, aims to investigate different neurobiological features of syndromes and of the shared neurobiological features between two syndromes. In fact, this approach should help us to better understand the neurobiological pathways underlying clinical entities, and even to distinguish different, more homogeneous, diagnostic subtypes.

title: @entity161 and XXXX : The road from similarities and clinical heterogeneity to neurobiological types.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive and functional impairment']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']

answer: @entity162 :: (MESH:D001714,Disease) :: ['bipolar disorder']


abstract: UNASSIGNED: Although diagnosis is a central issue in medical care, in psychiatry its value is still controversial. The function of diagnosis is to indicate treatments and to help clinicians take better care of @entity1 . The fundamental role of diagnosis is to predict outcome and prognosis. To date serious concern persists regarding the clinical utility and predictive validity of the diagnosis system in psychiatry, which is at the most syndromal. @entity161 and @entity162 , which nosologists consider two distinct disorders, are the most discussed @entity146 illnesses. Recent findings in different fields of @entity146 research, such as neuroimaging, neuropathology, neuroimmunology, neuropsychology and genetics, have led to other conceptualizations. Individuals with @entity161 or @entity162 vary greatly with regard to symptoms, illness course, treatment response, @entity73 and biological correlates. In fact, it is possible to find heterogeneous correlates even within the same syndrome, i.e., from one stage of the disorder to another. Thus, it is possible to identify different subsyndromes, which share some clinical and neurobiological characteristics. The main goal of modern psychiatry is to ovethrow these barriers and to obtain a better understanding of the biological profiles underlying heterogeneous clinical features and thus reduce the variance and lead to a homogeneous definition. The translational research model, which connects the basic neuroscience research field with clinical experience in psychiatry, aims to investigate different neurobiological features of syndromes and of the shared neurobiological features between two syndromes. In fact, this approach should help us to better understand the neurobiological pathways underlying clinical entities, and even to distinguish different, more homogeneous, diagnostic subtypes.

title: XXXX and @entity162 : The road from similarities and clinical heterogeneity to neurobiological types.

answer: @entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']


abstract: BACKGROUND: Initial tissue sampling for diagnosis of suspected @entity1491 ( @entity1491 ) is typically performed using a shave biopsy technique or punch biopsy. METHODS: Our realization of no residual @entity1491 findings after excision in some @entity1 with biopsy-proven @entity1491 diagnosed through a shave biopsy prompted us to conduct a retrospective study of all consecutive @entity1 with 127 BCCs who were treated in our department between 2006 and 2012. All @entity1 with incompletely excised BCCs after shave biopsy diagnosis were operated on by a single surgeon (R.G.), eliminating variables in preoperative evaluation and surgical technique including margin control and reconstructive approach. @entity1 demographics, initial @entity1491 site, size, subtype, duration between shave biopsy and surgery, size of excision, findings of intraoperative frozen section analysis, type of closure technique, and final pathology reports were analyzed. RESULTS: There were 108 residual BCCs diagnosed after surgical excision. Most of the108 BCCs were nodular (52) or micronodular (21) subtype. Eighteen BCCs were treated with excision and primary closure. Flap procedure was performed in 64 BCCs after excision. Twenty-six defects after excision were reconstructed using skin grafts. There was no evidence of residual @entity1491 in 15% of BCCs (19 @entity1 ) after surgical treatment. In other words, shave biopsy was found to be curative in 15% of BCCs. Seven @entity1 in no residual @entity1491 group received excision and primary closure. Eleven @entity1 underwent flap reconstruction, whereas only 1 @entity1 required skin grafting. Most of the @entity1 in this group had nodular or micronodular type @entity1491 (14/19). CONCLUSIONS: We were not able to identify any clinically significant predictors of residual versus no residual @entity1491 , at least within the context of the current study. Although most @entity1 diagnosed with @entity1491 had @entity41 for which they received surgical treatment, 15% of @entity1 had to undergo primary closure, skin graft, or flap procedure for negative residual @entity1491 . We would like to promote greater awareness on the subject among plastic surgeons treating BCCs. And, it is extremely important that the informed consent should include statements regarding possible reconstructive procedures even in the case of nonpersistent @entity5 from medicolegal standpoint.

title: Nonpersistence of XXXX After Diagnostic Shave Biopsy: Reconstruction When Specimen Is Negative During Surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumors']

entities_list: @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma', 'BCC']

answer: @entity1491 :: (MESH:D002280,Disease) :: ['Basal Cell Carcinoma']


abstract: @entity5822 ( @entity5822 ) negative @entity0 are reported to occur rarely. We studied 14 @entity5822 negative cases of @entity513 ( @entity513 ) detected during sentinel lymph node @entity3 work-up and immunohistochemistry panel in the work-up of metastatic @entity189 . Axillary lymph node @entity3 were present in seven @entity1 (50%). Oestrogen receptor (ER) was strongly positive in all cases: @entity7273 in 78%, @entity1722 in 7% and high proliferation index with Ki-67 >20% was seen in 71% of the cases. @entity3 and/or recurrence were found in 8 of 14 @entity1 (57%) with the mean clinical follow-up of 55   months. @entity3 sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 @entity1 received adjuvant chemotherapy. All 14 @entity1 received hormonal therapy and radiation therapy. Morphologically, @entity513 with neuroendocrine features was noted in 57%. @entity5473 stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these @entity5822 negative @entity0 were ER positive, mostly @entity1722 negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.

title: @entity5822 negative invasive XXXX : clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast tumours', 'breast carcinomas']

entities_list: @entity7273 :: ('5241', 'Gene') :: ['progesterone receptor']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of unknown origin']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['IDC', 'primary invasive ductal carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'Metastatic']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast carcinoma']


abstract: @entity5822 ( @entity5822 ) negative @entity0 are reported to occur rarely. We studied 14 @entity5822 negative cases of @entity513 ( @entity513 ) detected during sentinel lymph node @entity3 work-up and immunohistochemistry panel in the work-up of metastatic @entity189 . Axillary lymph node @entity3 were present in seven @entity1 (50%). Oestrogen receptor (ER) was strongly positive in all cases: @entity7273 in 78%, @entity1722 in 7% and high proliferation index with Ki-67 >20% was seen in 71% of the cases. @entity3 and/or recurrence were found in 8 of 14 @entity1 (57%) with the mean clinical follow-up of 55   months. @entity3 sites include multiple bones, brain, spinal cord, liver, pancreas, ovary, lung, lymph node other than ipsilateral axillary and skin. 12 of 14 @entity1 received adjuvant chemotherapy. All 14 @entity1 received hormonal therapy and radiation therapy. Morphologically, @entity513 with neuroendocrine features was noted in 57%. @entity5473 stain was positive in 57% and chromogranin was positive in 21% of the cases. In conclusion, these @entity5822 negative @entity0 were ER positive, mostly @entity1722 negative, had high Ki-67 and frequently showed neuroendocrine differentiation. More than half of these cases had a poor outcome.

title: XXXX negative invasive @entity0 : clinicopathological and immunohistochemical analysis of 14 cases with clinical follow-up.

answer: @entity5822 :: (3855,Gene) :: ['Cytokeratin 7']


abstract: UNASSIGNED: @entity1164 due to a @entity3291 is rarely reported in the literature. @entity299 are @entity5 of the heart, most frequently located in the left atrium. @entity1002 are rare. @entity1002 attached to the anterior papillary muscle are especially rare, with only 1 case being reported in the literature. @entity3291 have the potential to cause @entity887 , or @entity943 . We report a case of a 32-year-old @entity1 who sustained @entity944 and was found to have a left @entity67 attached to the anterior papillary muscle at autopsy. Although the subject also had evidence of a distant @entity583 and @entity384 , the @entity3291 was apparently clinically silent. @entity299 may be treated by surgical excision with excellent prognosis. However, they can remain silent and undiagnosed and, hence, have the potential for causing @entity1164 . In addition to the case report, we present a literature review of these issues involving @entity299 .

title: XXXX Causing @entity944 .

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['Sudden cardiac death', 'sudden cardiac death']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['benign tumors']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy']

entities_list: @entity3291 :: ('MESH:D009232', 'Disease') :: ['Myxomas', 'myxoma']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolization, obstruction']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac myxomas', 'Cardiac myxomas']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular myxoma']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['Left ventricular myxomas']

answer: @entity1002 :: (MESH:D018487,Disease) :: ['Left Ventricular Myxoma']


abstract: UNASSIGNED: @entity1164 due to a @entity3291 is rarely reported in the literature. @entity299 are @entity5 of the heart, most frequently located in the left atrium. @entity1002 are rare. @entity1002 attached to the anterior papillary muscle are especially rare, with only 1 case being reported in the literature. @entity3291 have the potential to cause @entity887 , or @entity943 . We report a case of a 32-year-old @entity1 who sustained @entity944 and was found to have a left @entity67 attached to the anterior papillary muscle at autopsy. Although the subject also had evidence of a distant @entity583 and @entity384 , the @entity3291 was apparently clinically silent. @entity299 may be treated by surgical excision with excellent prognosis. However, they can remain silent and undiagnosed and, hence, have the potential for causing @entity1164 . In addition to the case report, we present a literature review of these issues involving @entity299 .

title: @entity1002 Causing XXXX .

answer: @entity944 :: (MESH:D003645,Disease) :: ['Sudden Death']


abstract: Despite the established role of @entity2957 as a vector of various neurotropic viruses, such as the Rift Valley and West Nile viruses, as well as @entity3754 , little is known regarding the organism's reproductive physiology. As in other oviparous animals, @entity71564 , the most important source of nutrients for the embryo development, is digested by intracellular proteases. Using mass spectrometry, we have identified two @entity71565 homologues partially purified by self-proteolysis of Cx. quinquefasciatus total egg extract. The transcriptional profile of these two @entity71565 homologues was determined by quantitative RT-PCR, and the enzymatic activity associated with the peptidase was determined in ovaries after female engorgement. According to the VectorBase (vectorbase.org) annotation, both @entity71565 homologues shared approximately 66% identity in their @entity535 sequences. The two @entity71565 genes are expressed simultaneously in the fat body of the vitellogenic females, and enzymatic activity was detected within the ovaries, suggesting an extra-ovarian origin. Similar to the transcriptional profile of @entity71564 , @entity71565 transcripts were shown to accumulate post-blood meal and reached their highest expression at 36 h PBM. However, while @entity71564 expression decreased drastically at 48 h PBM, the expression of the cathepsins increased until 84 h PBM, at which time the females of our colony were ready for oviposition. The similarity between their transcriptional profiles strongly suggests a role for the @entity71565 homologues in vitellin degradation.

title: Two Cathepsins B Are Responsible for the Yolk Protein Hydrolysis in XXXX .

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity3754 :: ('MESH:D004605', 'Disease') :: ['lymphatic filariasis']

entities_list: @entity2957 :: ('7176', 'Species') :: ['Culex quinquefasciatus']

answer: @entity2957 :: (7176,Species) :: ['Culex quinquefasciatus']


abstract: UNASSIGNED: @entity16 are serious complications after hematopoietic stem cell transplantation (HSCT) and significantly contribute to morbidity and mortality. The purpose of this study was to investigate the clinical features and prognosis in pediatric @entity1 who had @entity16 after allogeneic HSCT. We retrospectively reviewed the medical records of @entity1 and adolescents (19 years old or younger) who underwent allogeneic HSCT at our institution from 2000 to 2012. A total of 383 @entity1 underwent 430 allogeneic transplantations. Among them, 73 episodes of @entity16 occurred in 70 @entity1 . The cumulative incidence of @entity16 at day 400 was 20.0%. Almost two thirds of the episodes (63.0%, 46 of 73) occurred within 100 days after transplantation. @entity9909 -related @entity2359 was observed as the most common cause of @entity2359 (47.9%, 35 of 73) and was significantly associated with earlier onset @entity16 , @entity410 , and @entity400 . It also showed a significant association with lower probability of @entity10 , @entity129 , and neurologic sequelae. In a multivariate analysis, days to neutrophil engraftment after HSCT, extensive @entity2132 ( @entity2132 ) and the existence of neurologic sequelae were identified as risk factors for mortality in @entity1 who had @entity16 (hazard ratio [HR], 1.08; 95% confidence interval [CI], 1.02 to 1.15; P  = .011; HR, 5.98; 95% CI, 1.71 to 20.90; P  = .005; and HR, 4.37; 95% CI, 1.12 to 17.05; P  = .034, respectively). However, there was no significant difference in the 5-year overall survival between the @entity1 who had @entity16 without sequelae and the @entity1 who did not have any @entity16 (57.3% versus 61.8%, P  = .906). In conclusion, we found that the major significant risk factors for mortality in pediatric recipients with @entity16 were the existence of neurologic sequelae and extensive @entity2132 .

title: Neurologic Complications after Allogeneic Hematopoietic Stem Cell Transplantation in XXXX : Analysis of Prognostic Factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['abnormality of cranial nerve']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurologic complications', 'neurologic complications']

entities_list: @entity9909 :: ('23523', 'Gene') :: ['Calcineurin inhibitor']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'chronic GVHD', 'chronic graft-versus-host disease']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity5 . No study has compared these variables after @entity0 to pre- @entity5 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity308 were measured with the six-item Center for Epidemiologic Studies @entity308 scale. Assessments occurred before and after the @entity5 diagnosis. @entity5 QOL and @entity308 to levels post-diagnosis and tested whether pre- @entity5 physical activity, stressful life events, @entity25 , and @entity158 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity5 levels, @entity308 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity308 returned to pre- @entity5 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity5 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity5 predictors were associated with all outcomes. @entity158 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity308 increased and QOL decreased following @entity0 compared with pre- @entity5 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: XXXX and quality of life before and after @entity0 in older @entity1 from the @entity1 's Health Initiative.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Women', 'people']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depressive symptoms', 'Depressive symptoms']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer diagnosis', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Hierarchical linear modeling compared pre-cancer', 'cancer']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbance']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity5 . No study has compared these variables after @entity0 to pre- @entity5 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity308 were measured with the six-item Center for Epidemiologic Studies @entity308 scale. Assessments occurred before and after the @entity5 diagnosis. @entity5 QOL and @entity308 to levels post-diagnosis and tested whether pre- @entity5 physical activity, stressful life events, @entity25 , and @entity158 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity5 levels, @entity308 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity308 returned to pre- @entity5 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity5 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity5 predictors were associated with all outcomes. @entity158 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity308 increased and QOL decreased following @entity0 compared with pre- @entity5 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: @entity308 and quality of life before and after XXXX in older @entity1 from the @entity1 's Health Initiative.

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer diagnosis']


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity5 . No study has compared these variables after @entity0 to pre- @entity5 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity308 were measured with the six-item Center for Epidemiologic Studies @entity308 scale. Assessments occurred before and after the @entity5 diagnosis. @entity5 QOL and @entity308 to levels post-diagnosis and tested whether pre- @entity5 physical activity, stressful life events, @entity25 , and @entity158 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity5 levels, @entity308 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity308 returned to pre- @entity5 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity5 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity5 predictors were associated with all outcomes. @entity158 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity308 increased and QOL decreased following @entity0 compared with pre- @entity5 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: @entity308 and quality of life before and after @entity0 in older XXXX from the @entity1 's Health Initiative.

answer: @entity1 :: (9606,Species) :: ['women']


abstract: PURPOSE: Distress and reduced quality of life (QOL) are common among @entity1 with @entity5 . No study has compared these variables after @entity0 to pre- @entity5 diagnosis levels. METHODS: Data on @entity1 with @entity0 50  years of age or older (n   =   6949) were analyzed from the @entity1 's Health Initiative (1993-2013). Health-related QOL (physical function, mental health) was measured using Rand-36. @entity308 were measured with the six-item Center for Epidemiologic Studies @entity308 scale. Assessments occurred before and after the @entity5 diagnosis. @entity5 QOL and @entity308 to levels post-diagnosis and tested whether pre- @entity5 physical activity, stressful life events, @entity25 , and @entity158 predicted post-diagnosis outcomes. RESULTS: Compared with pre- @entity5 levels, @entity308 increased (20.0  % increase at 0-6  months, 12.9  % increase at 6-12  months), while physical function (-3.882 points at 0-6  months, -3.545 at 6-12  months) and mental health decreased (-2.899 points at 0-6  months, -1.672 at 6-12  months) in the first year after diagnosis (all p   <   .01). @entity308 returned to pre- @entity5 levels after 10  years, but QOL remained significantly lower. At more than 10  years post-diagnosis, physical function was 2.379 points lower than pre- @entity5 levels (p   <   0.01) while mental health was 1.922 points lower (p   <   0.01). All pre- @entity5 predictors were associated with all outcomes. @entity158 predicted uniquely greater decreases in physical function post-diagnosis. CONCLUSIONS: @entity308 increased and QOL decreased following @entity0 compared with pre- @entity5 levels, particularly in the first year. IMPLICATIONS FOR CANCER SURVIVORS: QOL may remain lower for years after @entity0 , although decreases are small.

title: @entity308 and quality of life before and after @entity0 in older @entity1 from the XXXX 's Health Initiative.

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: Extensive evidence exists regarding the efficacy and acceptability of medical abortion through 63 days since last menstrual period (LMP). In Mexico City's Secretariat of Health (SSDF) outpatient facilities, @entity3927 - @entity396 medical abortion is the first-line approach for abortion care in this pregnancy range. Recent research demonstrates continued high rates of complete abortion through 70 days LMP. To expand access to legal abortion services in Mexico City (where abortion is legal through 12 weeks LMP), this study sought to assess the efficacy and acceptability of the standard outpatient approach through 70 days in two SSDF points of service. One thousand and one @entity1 seeking pregnancy termination were enrolled and given 200 mg @entity3927 followed by 800  g @entity396 24-48 hours later. @entity1 were asked to return to the clinic one week later for evaluation. The great majority of @entity1 (93.3%; 95% CI: 91.6-94.8) had complete abortions. @entity1 with pregnancies  <=8 weeks LMP had significantly higher success rates than @entity1 in the 9th or 10th weeks (94.9% vs. 90.5%; p = 0.01). The difference in success rates between the 9th and 10th weeks was not significant (90.0% vs. 91.2%; p = 0.71). The majority of @entity1 found the side effects (82.9%) and the use of @entity396 (84.4%) to be very acceptable or acceptable. This study provides additional evidence supporting an extended outpatient medical abortion regimen through 10 weeks LMP.

title: Safety, efficacy and acceptability of outpatient XXXX - @entity396 medical abortion through 70 days since last menstrual period in public sector facilities in Mexico City.

entities_list: @entity3927 :: ('MESH:D015735', 'Chemical') :: ['mifepristone']

entities_list: @entity396 :: ('MESH:D016595', 'Chemical') :: ['misoprostol']

answer: @entity3927 :: (MESH:D015735,Chemical) :: ['mifepristone']


abstract: Extensive evidence exists regarding the efficacy and acceptability of medical abortion through 63 days since last menstrual period (LMP). In Mexico City's Secretariat of Health (SSDF) outpatient facilities, @entity3927 - @entity396 medical abortion is the first-line approach for abortion care in this pregnancy range. Recent research demonstrates continued high rates of complete abortion through 70 days LMP. To expand access to legal abortion services in Mexico City (where abortion is legal through 12 weeks LMP), this study sought to assess the efficacy and acceptability of the standard outpatient approach through 70 days in two SSDF points of service. One thousand and one @entity1 seeking pregnancy termination were enrolled and given 200 mg @entity3927 followed by 800  g @entity396 24-48 hours later. @entity1 were asked to return to the clinic one week later for evaluation. The great majority of @entity1 (93.3%; 95% CI: 91.6-94.8) had complete abortions. @entity1 with pregnancies  <=8 weeks LMP had significantly higher success rates than @entity1 in the 9th or 10th weeks (94.9% vs. 90.5%; p = 0.01). The difference in success rates between the 9th and 10th weeks was not significant (90.0% vs. 91.2%; p = 0.71). The majority of @entity1 found the side effects (82.9%) and the use of @entity396 (84.4%) to be very acceptable or acceptable. This study provides additional evidence supporting an extended outpatient medical abortion regimen through 10 weeks LMP.

title: Safety, efficacy and acceptability of outpatient @entity3927 - XXXX medical abortion through 70 days since last menstrual period in public sector facilities in Mexico City.

answer: @entity396 :: (MESH:D016595,Chemical) :: ['misoprostol']


abstract: BACKGROUND: Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. @entity205 ( @entity9472 ), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these infectious changes, based on random clinical observations. In the present study, the effects of @entity2348 on @entity9472 metabolism were studied in renal transplant @entity1 and subsequent nephrotoxicity was monitored. METHODS: Twenty renal transplant @entity1 , diagnosed with fungal or @entity2348 , were recruited from the renal transplantation outpatient clinic in Alexandria University Hospitals. No dose adjustment in @entity9472 was performed at least 1  week before the onset of @entity281 . Exclusion criteria were @entity1 with acute or chronic unstable @entity409 , elderly @entity1 , and @entity1 on concomitant drugs affecting @entity9472 metabolism. @entity9472 trough levels and serum @entity1011 (SCR) concentrations were measured by fluorescence polarization immunoassay and enzymatic assay, respectively, pre- @entity281 , during @entity281 and in many cases, post @entity281 . RESULTS: @entity9472 trough levels and SCR concentrations increased significantly during the @entity281 (P  <  0.001, P  =  0.002) respectively. Of the @entity1 , 87% experienced a concomitant rise in @entity9472 trough level and SCR concentrations. No significant difference between pre- @entity281 and post- @entity281 levels of @entity9472 trough and SCR was found. CONCLUSIONS: @entity9472 trough and SCR levels increased during @entity2348 and returned to pre- @entity281 levels once the @entity281 was resolved. The data generated stress the importance of monitoring @entity9472 levels during episodes of @entity281 . Our recommendations concerning @entity9472 dose adjustment differ according to severity and duration of @entity281 .

title: Effect of active @entity281 on cytochrome P450-mediated metabolism of XXXX in renal transplant @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial and fungal infections', 'bacterial infection', 'bacterial and fungal infection']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['Cyclosporine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity205 :: (MESH:D016572,Chemical) :: ['cyclosporine']


abstract: BACKGROUND: Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. @entity205 ( @entity9472 ), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these infectious changes, based on random clinical observations. In the present study, the effects of @entity2348 on @entity9472 metabolism were studied in renal transplant @entity1 and subsequent nephrotoxicity was monitored. METHODS: Twenty renal transplant @entity1 , diagnosed with fungal or @entity2348 , were recruited from the renal transplantation outpatient clinic in Alexandria University Hospitals. No dose adjustment in @entity9472 was performed at least 1  week before the onset of @entity281 . Exclusion criteria were @entity1 with acute or chronic unstable @entity409 , elderly @entity1 , and @entity1 on concomitant drugs affecting @entity9472 metabolism. @entity9472 trough levels and serum @entity1011 (SCR) concentrations were measured by fluorescence polarization immunoassay and enzymatic assay, respectively, pre- @entity281 , during @entity281 and in many cases, post @entity281 . RESULTS: @entity9472 trough levels and SCR concentrations increased significantly during the @entity281 (P  <  0.001, P  =  0.002) respectively. Of the @entity1 , 87% experienced a concomitant rise in @entity9472 trough level and SCR concentrations. No significant difference between pre- @entity281 and post- @entity281 levels of @entity9472 trough and SCR was found. CONCLUSIONS: @entity9472 trough and SCR levels increased during @entity2348 and returned to pre- @entity281 levels once the @entity281 was resolved. The data generated stress the importance of monitoring @entity9472 levels during episodes of @entity281 . Our recommendations concerning @entity9472 dose adjustment differ according to severity and duration of @entity281 .

title: Effect of active XXXX on cytochrome P450-mediated metabolism of @entity205 in renal transplant @entity1 .

answer: @entity281 :: (MESH:D007239,Disease) :: ['infection']


abstract: BACKGROUND: Infections downregulate cytochrome-P activities and thus may alter drug disposition, especially for drugs with a narrow therapeutic index. @entity205 ( @entity9472 ), still used for the prevention of allograft rejection in renal transplant recipients in Egypt, seems to be affected by these infectious changes, based on random clinical observations. In the present study, the effects of @entity2348 on @entity9472 metabolism were studied in renal transplant @entity1 and subsequent nephrotoxicity was monitored. METHODS: Twenty renal transplant @entity1 , diagnosed with fungal or @entity2348 , were recruited from the renal transplantation outpatient clinic in Alexandria University Hospitals. No dose adjustment in @entity9472 was performed at least 1  week before the onset of @entity281 . Exclusion criteria were @entity1 with acute or chronic unstable @entity409 , elderly @entity1 , and @entity1 on concomitant drugs affecting @entity9472 metabolism. @entity9472 trough levels and serum @entity1011 (SCR) concentrations were measured by fluorescence polarization immunoassay and enzymatic assay, respectively, pre- @entity281 , during @entity281 and in many cases, post @entity281 . RESULTS: @entity9472 trough levels and SCR concentrations increased significantly during the @entity281 (P  <  0.001, P  =  0.002) respectively. Of the @entity1 , 87% experienced a concomitant rise in @entity9472 trough level and SCR concentrations. No significant difference between pre- @entity281 and post- @entity281 levels of @entity9472 trough and SCR was found. CONCLUSIONS: @entity9472 trough and SCR levels increased during @entity2348 and returned to pre- @entity281 levels once the @entity281 was resolved. The data generated stress the importance of monitoring @entity9472 levels during episodes of @entity281 . Our recommendations concerning @entity9472 dose adjustment differ according to severity and duration of @entity281 .

title: Effect of active @entity281 on cytochrome P450-mediated metabolism of @entity205 in renal transplant XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Preoperative @entity5 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity1 with differentiated @entity259 is still unclear. METHODS: Seventy-six DTC @entity1 were prospectively recruited. Preoperative serum samples were collected and measured for @entity878 , @entity3658 , @entity877 , @entity7 , and @entity9205 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity7 serum levels were independent predictors of extrathyroidal extension. The @entity9205 serum level was an independent factor for lymph node @entity3 and @entity7 was an independent factor for distant @entity3 . None of these serum angiogenetic factors were significantly different between @entity1 who were disease free and those with recurrences. The presence of lymph node @entity3 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity7 and @entity9205 levels were significantly elevated in DTC @entity1 with distant and lymph node @entity3 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: @entity9205 and A Preoperative Serum Levels Predict Nodal and Distant @entity3 in Differentiated XXXX @entity1 .

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']

answer: @entity259 :: (MESH:D013964,Disease) :: ['Thyroid Cancer']


abstract: BACKGROUND: Preoperative @entity5 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity1 with differentiated @entity259 is still unclear. METHODS: Seventy-six DTC @entity1 were prospectively recruited. Preoperative serum samples were collected and measured for @entity878 , @entity3658 , @entity877 , @entity7 , and @entity9205 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity7 serum levels were independent predictors of extrathyroidal extension. The @entity9205 serum level was an independent factor for lymph node @entity3 and @entity7 was an independent factor for distant @entity3 . None of these serum angiogenetic factors were significantly different between @entity1 who were disease free and those with recurrences. The presence of lymph node @entity3 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity7 and @entity9205 levels were significantly elevated in DTC @entity1 with distant and lymph node @entity3 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: @entity9205 and A Preoperative Serum Levels Predict Nodal and Distant XXXX in Differentiated @entity259 @entity1 .

answer: @entity3 :: (MESH:D009362,Disease) :: ['Metastases']


abstract: BACKGROUND: Preoperative @entity5 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity1 with differentiated @entity259 is still unclear. METHODS: Seventy-six DTC @entity1 were prospectively recruited. Preoperative serum samples were collected and measured for @entity878 , @entity3658 , @entity877 , @entity7 , and @entity9205 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity7 serum levels were independent predictors of extrathyroidal extension. The @entity9205 serum level was an independent factor for lymph node @entity3 and @entity7 was an independent factor for distant @entity3 . None of these serum angiogenetic factors were significantly different between @entity1 who were disease free and those with recurrences. The presence of lymph node @entity3 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity7 and @entity9205 levels were significantly elevated in DTC @entity1 with distant and lymph node @entity3 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: XXXX and A Preoperative Serum Levels Predict Nodal and Distant @entity3 in Differentiated @entity259 @entity1 .

answer: @entity9205 :: (2277,Gene) :: ['VEGF-D']


abstract: BACKGROUND: Preoperative @entity5 aggressiveness biomarkers may help surgeons decide the extent of an operation. However, whether serum angiogenetic factors can be used to predict the prognosis of @entity1 with differentiated @entity259 is still unclear. METHODS: Seventy-six DTC @entity1 were prospectively recruited. Preoperative serum samples were collected and measured for @entity878 , @entity3658 , @entity877 , @entity7 , and @entity9205 levels. The potential correlations between their serum levels and clinicopathologic features as well as their prognoses were analyzed. RESULTS: Older age (>45 years old) and higher @entity7 serum levels were independent predictors of extrathyroidal extension. The @entity9205 serum level was an independent factor for lymph node @entity3 and @entity7 was an independent factor for distant @entity3 . None of these serum angiogenetic factors were significantly different between @entity1 who were disease free and those with recurrences. The presence of lymph node @entity3 was the only independent factor for recurrence over the 2-year follow-up. CONCLUSION: Preoperative serum @entity7 and @entity9205 levels were significantly elevated in DTC @entity1 with distant and lymph node @entity3 . These findings, when combined with other clinicopathological factors, may help in surgical decisions.

title: @entity9205 and A Preoperative Serum Levels Predict Nodal and Distant @entity3 in Differentiated @entity259 XXXX .

answer: @entity1 :: (9606,Species) :: ['Patients']