abstract: UNASSIGNED: Specific targets for most @entity28 candidate genes discovered by genomewide association studies remain unknown. Such genes are often highly expressed in the hypothalamus, indicating their role in energy homeostasis. We aimed to evaluate the associations of selected gene variants with adiposity and dietary traits. Anthropometric parameters, fat mass, dietary intake (total energy, fat, protein, @entity1735 , fiber, and @entity460 ) and 10 gene variants (in/near @entity20903 , @entity21944 , @entity23157 , @entity11620 , @entity2252 , @entity23156 , @entity1628 and @entity18957 ) were analyzed in 1953 Czech individuals aged 10.0 to 18.0 years (1035 nonoverweight and 918 overweight: body mass index [BMI] >= 90th percentile). Obesity risk alleles of @entity20903 @entity71825 , @entity23156 @entity71826 , and @entity18957 @entity18956 were related to increased body weight and BMI (P < .005). The @entity18957 variant also showed a significant positive association with waist circumference and fat mass (P < .001). Overweight adolescents had a lower total energy intake (P < .001) but a higher percentage of fat (P = .009) and protein intake (P < .001) than the nonoverweight subjects. There was also a lower @entity460 intake in the overweight group (P < .001). An association with at least one component of dietary intake was found in 3 of 10 studied gene variants. The @entity1628 @entity24854 was associated negatively with protein (P = .012) and positively associated with fiber (P = .032) intakes. The @entity28 risk alleles of @entity2252 @entity23158 and @entity18957 @entity18956 were related to a lower @entity460 intake (P = .001 and .037). The effects of @entity18957 and @entity1628 variants, however, disappeared after corrections for multiple testing. Our results suggest that the common @entity2252 variant may influence dietary @entity460 intake independent of BMI.

title: A common variant near XXXX is associated with dietary @entity460 intake in adolescents.

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

answer: @entity2252 :: (627,Gene) :: ['BDNF']


abstract: BACKGROUND: @entity1 who develop critical @entity943 during left ventricular assist device (LVAD) perfusion have a low survival rate. For diagnosis of unexpected @entity299 , new heart-monitoring methods are required for @entity1 supported by LVAD perfusion. Ventricular electrocardiography using electrodes implanted in the ventricle to detect heart contractions is unsuitable if the heart is abnormal. Left ventricular impedance (LVI) is useful for monitoring heart movement but does not show abnormal action potential in the heart muscle. OBJECTIVES: To detect detailed abnormal heart conditions, we obtained ventricular electrocardiograms (v-ECGs) and LVI simultaneously in porcine models connected to LVADs. METHODS: In the porcine models, electrodes were set on the heart apex and ascending aorta for real-time measurements of v-ECGs and LVI. As the carrier current frequency of the LVI was adjusted to 30  kHz, it was easily derived from the original v-ECG signal by using a high-pass filter (cutoff: 10  kHz). In addition, v-ECGs with a frequency band of 0.1   -   120  Hz were easily derived using a low-pass filter. Simultaneous v-ECG and LVI data were compared to detect heart volume changes during the Q-T period when the heart contracted. A new real-time algorithm for comparison of v-ECGs and LVI determined whether the porcine heartbeats were normal or abnormal. Several abnormal heartbeats were detected using the LVADs operating in asynchronous mode, most of which were @entity1540 ( @entity1540 ). To evaluate the accuracy of the new method, the results obtained were compared to normal ECG data and cardiac output measured simultaneously using commercial devices. RESULTS: The new method provided more accurate detection of abnormal @entity299 . This method can be used for various @entity299 , even those in which the cardiac output is heavily affected by LVAD operation.

title: Heart monitoring using left ventricle impedance and ventricular electrocardiography in left ventricular assist device XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity1540 :: ('MESH:D018879', 'Disease') :: ['premature ventricle contractions', 'PVCs']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart diseases', 'heart abnormalities', 'heart movements']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: This study was designed to analyze the three-dimensional structure of platelet-rich fibrin (PRF) gel as scaffold for dental pulp regeneration, and to investigate the effect of PRF gel on the proliferation of @entity1 dental pulp cells (hDPCs) in vitro. METHODS: PRF gel prepared by Choukroun's protocols was evaluated by light microscope and scanning electron microscope (SEM). The extract of PRF gel was collected at the time point of 7th day. The experimental group was divided into 2 subgroups (25% and 75%) according to the volume fraction of PRF gel extract. The 2 subgroups were named 1PRF and 3PRF, respectively. The hDPCs were isolated and cultured in DMEM with 1PRF and 3PRF, respectively. Cell proliferation was detected using cell counting kit-8 (CCK-8) at 24, 48, 72, 96, 120, 144 and 168 h, respectively. The data was analyzed with SPSS16.0 software package. RESULTS: Platelet and leukocyte were mainly distributed at the junction between the red corpuscles and the PRF gel, which was called "buffy coat". "Buffy coat" was constructed by large and dense fibrin clusters. At 24, 48, 72 and 96 h, there was no significant difference ( @entity5771 ) value of optical density( @entity5771 ) between experimental group and control group(P>0.05). At 120, 144 and 168 h, the @entity5771 value in the experimental group was significant higher than that of the control group (P<0.05); there was no significant difference of @entity5771 value between group 1PRF and 3PRF (P>0.05). CONCLUSIONS: The results confirm that the three-dimensional structure of PRF gel is constituted by fibrin network. A large amount of platelet and leukocyte which can release high quantities of growth factors are concentrated in the PRF gel. The extract of PRF gel can accelerate the proliferation of hDPCs in time-dependent manner. PRF gel may be a proper scaffold for pulp regeneration. Supported by National Natural Science Foundation of China (81160133).

title: [Three-dimensional structure of platelet-rich fibrin gel and its effect on proliferation of XXXX dental pulp cells in vitro].

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: Polymerase epsilon (POLE) is a DNA polymerase with a proofreading (exonuclease) domain, responsible for the recognition and excision of mispaired bases, thereby allowing high-fidelity DNA replication to occur. The Cancer Genome Atlas research network recently identified an ultramutated group of @entity1204 , characterized by mutations in POLE, and exceptionally high substitution mutation rates. These POLE mutated @entity1204 were almost exclusively of the endometrioid histotype. The prevalence and patterns of POLE mutated @entity5 in @entity4348 of the ovary, however, have not been studied in detail. MATERIALS AND METHODS: In this study, we investigate the frequency of POLE exonuclease domain mutations in a series of 89 @entity43 . RESULTS: We found POLE mutations in 4 of 89 (4.5%) cases, occurring in 3 of 23 (13%) International Federation of Gynecology and Obstetrics (FIGO) grade 1, 1 of 43 (2%) FIGO grade 2, and 0 of 23 (0%) FIGO grade 3 @entity5 . All mutations were somatic missense point mutations, occurring at the commonly reported hotspots, @entity41259 and @entity54846 . All 3 POLE-mutated FIGO grade 1 @entity5 displayed prototypical histology, and the POLE-mutated FIGO grade 2 @entity5 displayed morphologic heterogeneity with focally high-grade features. All 4 @entity1 with POLE-mutated @entity5 followed an uneventful clinical course with no disease recurrence; however, this finding was not statistically significant (P = 0.59). CONCLUSIONS: The low rate of POLE mutations in @entity43 and their predominance within the low FIGO grade @entity5 are in contrast to the findings in the endometrium.

title: Polymerase Epsilon Exonuclease Domain Mutations in Ovarian XXXX .

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial tumors', 'endometrial carcinomas']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian endometrioid carcinoma', 'ovarian endometrioid carcinomas']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity4348 :: ('MESH:D018269', 'Disease') :: ['endometrioid carcinomas']

answer: @entity4348 :: (MESH:D018269,Disease) :: ['Endometrioid Carcinoma']


abstract: OBJECTIVE: To establish C6 @entity13 models using stereotactic technique, and to study effects of @entity1986 ( @entity1986 ) in @entity35 models of @entity11 . METHODS: C6 @entity11 cells were cultured in dulbecco's minimum essential medium (DMEM) cell culture medium. The in vitro C6 cell cultures were stereotaxically implanted into the right caudate nucleus of @entity35 brain. Presence of @entity5 was confirmed with Factor VIII R, @entity1710 - @entity1711 stain, staining of glial fibrillary acid protein, and S-100 immunohistochemistry. After magnetic resonance (MR) scanning and correction of @entity5 location, the models were divided into groups according to the treating time and laser power (2-10 W). Semiconductor laser optical fibers were inserted in @entity5 for @entity1986 . Cortex's temperature conducted from the center target was measured using infrared thermograph, and deep-tissue temperature around the target was measured using a thermocouple. RESULTS: @entity35 C6 @entity11 were inoculated with optimized stereotactic technique. These @entity11 resembled @entity1 @entity11 in terms of histopathological features. Such models are more reliable and reproducible, with 100% yield of @entity5 and no extracranial growth extension. The difference between cortex temperature conducted from center target and deep-tissue temperature around target was not statistically significant. CONCLUSION: The @entity35 C6 @entity13 model established in the study was a perfect model to study @entity1986 of @entity11 . Infrared thermograph technique measured temperature conveniently and effectively. The technique is noninvasive, and the obtained data could be further processed using software used in @entity1986 research. To measure deep-tissue temperature, combining thermocouple with infrared thermograph technique would present better results.

title: Establishment of C6 XXXX models through stereotactic technique for @entity1986 research.

entities_list: @entity13 :: ('MESH:C564230', 'Disease') :: ['brain glioma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'intracranial tumor']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma', 'gliomas']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity1986 :: ('MESH:D009395', 'Disease') :: ['laser interstitial thermotherapy', 'LITT']

answer: @entity13 :: (MESH:C564230,Disease) :: ['brain glioma']


abstract: OBJECTIVE: To establish C6 @entity13 models using stereotactic technique, and to study effects of @entity1986 ( @entity1986 ) in @entity35 models of @entity11 . METHODS: C6 @entity11 cells were cultured in dulbecco's minimum essential medium (DMEM) cell culture medium. The in vitro C6 cell cultures were stereotaxically implanted into the right caudate nucleus of @entity35 brain. Presence of @entity5 was confirmed with Factor VIII R, @entity1710 - @entity1711 stain, staining of glial fibrillary acid protein, and S-100 immunohistochemistry. After magnetic resonance (MR) scanning and correction of @entity5 location, the models were divided into groups according to the treating time and laser power (2-10 W). Semiconductor laser optical fibers were inserted in @entity5 for @entity1986 . Cortex's temperature conducted from the center target was measured using infrared thermograph, and deep-tissue temperature around the target was measured using a thermocouple. RESULTS: @entity35 C6 @entity11 were inoculated with optimized stereotactic technique. These @entity11 resembled @entity1 @entity11 in terms of histopathological features. Such models are more reliable and reproducible, with 100% yield of @entity5 and no extracranial growth extension. The difference between cortex temperature conducted from center target and deep-tissue temperature around target was not statistically significant. CONCLUSION: The @entity35 C6 @entity13 model established in the study was a perfect model to study @entity1986 of @entity11 . Infrared thermograph technique measured temperature conveniently and effectively. The technique is noninvasive, and the obtained data could be further processed using software used in @entity1986 research. To measure deep-tissue temperature, combining thermocouple with infrared thermograph technique would present better results.

title: Establishment of C6 @entity13 models through stereotactic technique for XXXX research.

answer: @entity1986 :: (MESH:D009395,Disease) :: ['laser interstitial thermotherapy']


abstract: BACKGROUND: Inhaled corticosteroids (ICS) treatment for @entity565 control is generally focused on lung function and symptoms, but inadequately correlated with @entity32 . OBJECTIVE: To compare @entity565 control in a group of @entity1 whose treatment was based on fraction of exhaled @entity842 (FENO) and sputum eosinophils (intervention group) with a group in whom treatment was based on clinical score (control group). Study design and primary outcome: Randomized parallel-group longitudinal 24-month study including 5 visits every 6 months. A combination of @entity565 exacerbation rate and symptom score at 24 months was the primary outcome. @entity1 : Fourteen @entity1 with @entity1712 per group were included. RESULTS: In the intervention group, exacerbation rate/ @entity1 /year was reduced at 12 months (0.82) (-73%) and, to a greater extent at 24 months (0.5) (-84%) compared with baseline (3.21, p<0.01). In the control group, a significant reduction in exacerbation rate/ @entity1 /year was only observed between month 12 (3.0) and 24 (2.0, -33%, p<0.01). At 24 months, exacerbation rate was lower (-75%) in the intervention (0.5) than in the control group (2.0, p<0.05). Compared with baseline, mean symptom scores at 24 months were reduced in both groups (intervention group: -72%; control group: -60%), but were lower in the intervention (8.1  1.0, p<0.05; -27%) than in the control group (11  2.6). ICS dose gradually increased in both groups throughout the study, with no between-group differences. CONCLUSION: Compared with conventional strategy, longitudinal monitoring of FENO and sputum eosinophils improves @entity1712 control in terms of reduced symptoms and exacerbations without additional increase in ICS treatment.

title: The Combined Impact of Exhaled XXXX and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['airway inflammation']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilic asthma']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

answer: @entity842 :: (MESH:D009569,Chemical) :: ['Nitric Oxide']


abstract: OBJECTIVE: To evaluate the efficacy of pre-treatment of idiopathic oligozoospermic @entity1 with r-hFSH to improve the clinical results of ICSI. @entity1 AND METHODS: 82 infertile couples due to male factor who attended our center were included in the study. Thirty-six were randomized to the treatment group (group A) and forty-six to the control group (group B). The male partners in group A were treated with recombinant @entity1 FSH (r-hFSH; Gonal F  ) 150 IU subcutaneously three times a week for a 3-months period. The control group (group B) did not receive any treatment. After the treatment couples of both groups underwent a cycle of ICSI. RESULTS: The fertilization rate was comparable in both groups. However, in the treatment group (group A), the clinical pregnancy rate was significantly higher (42%) compared to the control group (group B) (20%) (p < 0.02). Also, the implantation rate was significantly higher in treatment group (26%) compared to the control (15%) (p < 0.04). Miscarriage rate was lower (15.7%) in the treatment group than in the control (43.7%), and this difference was statistically significant (p < 0.05). CONCLUSIONS: Treatment of @entity4810 with r-hFSH before ICSI improves clinical pregnancy rate, increases implantation rate and decreases the early @entity393 .

title: The use of r-hFSH in treatment of XXXX before ICSI.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PATIENTS']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['pregnancy loss']

entities_list: @entity4810 :: ('MESH:D007248', 'Disease') :: ['idiopathic male factor infertility']

answer: @entity4810 :: (MESH:D007248,Disease) :: ['idiopathic male factor infertility']


abstract: OBJECTIVE: The prognostic role of phosphatase and tensin homolog ( @entity983 ) in @entity1149 ( @entity1149 ) has been controversial. @entity1 AND METHODS: In this study, levels of @entity983 expression were investigated in @entity1149 @entity1 and their prognostic value in @entity1149 was assessed. @entity983 expression in @entity5 tissues from 68 @entity1149 @entity1 was analyzed using immunohistochemistry and confocal microscopy. Survival analysis was performed using the log-rank test and Cox proportional hazards regression analysis. RESULTS: @entity1149 @entity1 classified as expressers of high levels of @entity983 (n = 46) had better prognoses than those classified as expressers of low levels (mean survival 17.1 versus 12.9 months, log-rank p = 0.038). In @entity1 with @entity420 ( @entity420 ), high @entity983 expression (n = 9) was associated with significantly longer survival than low @entity983 expression (mean survival 23.50 versus 15.54 months, log-rank p = 0.043). High levels of @entity983 expression resulted in 43% reduction in risk for all @entity1149 @entity1 (HR = 0.57, 95% CI: 0.33-0.98, p = 0.041). @entity983 expression and clinical stage remained significantly associated with survival after adjustment for age, sex and @entity5 type (HR = 0.56, 95% CI: 0.32-0.99; p = 0.048; HR = 0.54, 95% CI: 0.36-0.97; p = 0.045). No significant difference in continuous @entity983 expression levels was observed among groups with different clinical or pathological characteristics (p > 0.17). When levels of @entity983 expression were binarized using the optimal cutpoint, higher levels of @entity983 expression were observed in @entity1 with T1/T2 than in those with T3/T4 (80% and 58% respectively, p = 0.049) and in @entity1 with @entity420 than in those with @entity957 ( @entity957 ) (78% and 58% respectively, p = 0.08). No significant difference in binarized @entity983 expression levels was found among groups with any other clinical/pathologic characteristic (p > 0.28). CONCLUSIONS: Our results suggest that high levels of @entity983 expression may be favorable prognostic marker in @entity1149 @entity1 .

title: High levels of phosphatase and tensin homolog expression predict favorable prognosis in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous-cell carcinoma', 'SCC']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['AC', 'adenocarcinoma']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']


abstract: OBJECTIVE: The prognostic role of phosphatase and tensin homolog ( @entity983 ) in @entity1149 ( @entity1149 ) has been controversial. @entity1 AND METHODS: In this study, levels of @entity983 expression were investigated in @entity1149 @entity1 and their prognostic value in @entity1149 was assessed. @entity983 expression in @entity5 tissues from 68 @entity1149 @entity1 was analyzed using immunohistochemistry and confocal microscopy. Survival analysis was performed using the log-rank test and Cox proportional hazards regression analysis. RESULTS: @entity1149 @entity1 classified as expressers of high levels of @entity983 (n = 46) had better prognoses than those classified as expressers of low levels (mean survival 17.1 versus 12.9 months, log-rank p = 0.038). In @entity1 with @entity420 ( @entity420 ), high @entity983 expression (n = 9) was associated with significantly longer survival than low @entity983 expression (mean survival 23.50 versus 15.54 months, log-rank p = 0.043). High levels of @entity983 expression resulted in 43% reduction in risk for all @entity1149 @entity1 (HR = 0.57, 95% CI: 0.33-0.98, p = 0.041). @entity983 expression and clinical stage remained significantly associated with survival after adjustment for age, sex and @entity5 type (HR = 0.56, 95% CI: 0.32-0.99; p = 0.048; HR = 0.54, 95% CI: 0.36-0.97; p = 0.045). No significant difference in continuous @entity983 expression levels was observed among groups with different clinical or pathological characteristics (p > 0.17). When levels of @entity983 expression were binarized using the optimal cutpoint, higher levels of @entity983 expression were observed in @entity1 with T1/T2 than in those with T3/T4 (80% and 58% respectively, p = 0.049) and in @entity1 with @entity420 than in those with @entity957 ( @entity957 ) (78% and 58% respectively, p = 0.08). No significant difference in binarized @entity983 expression levels was found among groups with any other clinical/pathologic characteristic (p > 0.28). CONCLUSIONS: Our results suggest that high levels of @entity983 expression may be favorable prognostic marker in @entity1149 @entity1 .

title: High levels of phosphatase and tensin homolog expression predict favorable prognosis in XXXX with @entity1149 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity64 rates were found to have seasonal variations. However, previous studies using air temperature, humidity, or air pressure separately were not adequate, and the study catchment was not clearly drawn. Therefore, here we proposed to use a thermal index called physiologically equivalent temperature (PET) that incorporates air temperature, humidity, wind speed, cloud cover, air pressure and radiation flux from a biometeorological approach to estimate the effect of weather as physiologically equivalent on @entity385 onsets in an Austrian population. Eight thousand four hundred @entity64 events in Vienna registered within the Austrian @entity64 Unit Register from January 1, 2004 to December 31, 2010 were included and were correlated with the weather data, obtained from the Central Institute for Meteorology and Geodynamics in the same area and study time period and calculated as PET (  C). Statistical analysis involved Poisson regression modeling. The median age was 74  years, and @entity1 made up 49  % of the entire population. Eighty percent had @entity101 while 25.4  % were current smokers. Of note, 26.5  % had @entity6 , 28.9  % had pre- @entity64 , and 11.5  % had pre- @entity583 . We have observed that onsets were higher on the weekdays than on the weekend. However, we did not find any significant association between PETs and @entity385 onsets by subtypes in Vienna. We did not observe any significant associations between PETs and @entity385 onsets by subtypes in Vienna. Hospital admission peaks on the weekdays might be due to hospital administration reasons.

title: Weather as physiologically equivalent was not associated with XXXX onsets in Vienna, 2004-2010.

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'eleven stroke', 'Stroke']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: BACKGROUND: Cortical lesions account for a larger proportion of @entity62 . They are often missed on conventional MRI. Recently studies improved the detection of cortical lesions using 7T T2(   ), 7T MPRAGE and 3T @entity17367 but it seems that we are still able to detect only "the tip of the iceberg". In this study we report for the first time the systematic use of high resolution MTR in @entity15 and compare MTR lesion detection with 7T MPRAGE, 7T T2(   ) and 3T 3D @entity17367 . OBJECTIVES: We report the use of high resolution, fast, magnetisation transfer imaging (MTI) at 7T in @entity15 focusing on the detection of cortical lesions. SUBJECTS AND METHODS: Eighteen @entity1 with @entity15 were scanned (Expanded Disability Status Scale score: 3.0, mean age: 48 years, mean disease duration: 7.25 years). The scans were compared to nine healthy control subjects (mean age 36.5 years). DATA ACQUISITION: We acquired 7T MPRAGE images, 7T MTR maps, 7T T2(   )and 3T 3D @entity17367 . The WM was segmented from the MPRAGE and removed to obtain only the cortical grey matter ribbon (cGMR) mask. The mask was then applied to the different modalities (MPRAGE, MTR, @entity17367 , T2(   )w) previously registered onto the MPRAGE volume. The analysis of the cGMR was performed by two observers blinded to the disease state. RESULTS: In @entity1 with @entity15 365 lesions in total were detected with 7T MTR (mean 20.28 lesions per @entity1 ), 289 lesions were detected with 7T MPRAGE (mean 16.06 lesions) and 231 lesions were detected with 7T T2(   ) (mean 12.83 lesions). In the 8 @entity15 subjects who had 3T 3D @entity17367 acquired on the same day, a total of 136 lesions (mean 17 lesions per @entity1 ) were detected as opposed to 171 lesions with 7T MTR, 147 lesions were detected with 7T MPRAGE and 126 lesions with 7T T2(   ) in the same @entity1 . CONCLUSION: We found that 7T MTR, in less than 10min scanning time, was able to detect cortical lesions. In this study we found that 7T MTR was better in detecting intracortical lesions in comparison with 7T T2(   ), 7T MPRAGE, and 3T 3D @entity17367 . since only a very few intracortical lesions were detected in healthy controls in our blind assessment, it is likely that the lesions detected represent focal grey matter demyelination. High resolution MT imaging has especially revealed cortical changes that have not been recognised by other MR sequences. MTR maps were noisier than MPRAGE, T2(   ) and @entity17367 , but also better in localising cortical lesions. As MTR is more pathologically specific than other sequences in detecting tissue myelination, it raises the possibility that high resolution MTR will be able to demonstrate cortical remyelination in vivo.

title: Improved detection of focal cortical lesions using 7T magnetisation transfer imaging in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['brain demyelination than white matter (WM) lesions']

answer: @entity15 :: (MESH:D009103,Disease) :: ['multiple sclerosis']


abstract: BACKGROUND: Cortical lesions account for a larger proportion of @entity62 . They are often missed on conventional MRI. Recently studies improved the detection of cortical lesions using 7T T2(   ), 7T MPRAGE and 3T @entity17367 but it seems that we are still able to detect only "the tip of the iceberg". In this study we report for the first time the systematic use of high resolution MTR in @entity15 and compare MTR lesion detection with 7T MPRAGE, 7T T2(   ) and 3T 3D @entity17367 . OBJECTIVES: We report the use of high resolution, fast, magnetisation transfer imaging (MTI) at 7T in @entity15 focusing on the detection of cortical lesions. SUBJECTS AND METHODS: Eighteen @entity1 with @entity15 were scanned (Expanded Disability Status Scale score: 3.0, mean age: 48 years, mean disease duration: 7.25 years). The scans were compared to nine healthy control subjects (mean age 36.5 years). DATA ACQUISITION: We acquired 7T MPRAGE images, 7T MTR maps, 7T T2(   )and 3T 3D @entity17367 . The WM was segmented from the MPRAGE and removed to obtain only the cortical grey matter ribbon (cGMR) mask. The mask was then applied to the different modalities (MPRAGE, MTR, @entity17367 , T2(   )w) previously registered onto the MPRAGE volume. The analysis of the cGMR was performed by two observers blinded to the disease state. RESULTS: In @entity1 with @entity15 365 lesions in total were detected with 7T MTR (mean 20.28 lesions per @entity1 ), 289 lesions were detected with 7T MPRAGE (mean 16.06 lesions) and 231 lesions were detected with 7T T2(   ) (mean 12.83 lesions). In the 8 @entity15 subjects who had 3T 3D @entity17367 acquired on the same day, a total of 136 lesions (mean 17 lesions per @entity1 ) were detected as opposed to 171 lesions with 7T MTR, 147 lesions were detected with 7T MPRAGE and 126 lesions with 7T T2(   ) in the same @entity1 . CONCLUSION: We found that 7T MTR, in less than 10min scanning time, was able to detect cortical lesions. In this study we found that 7T MTR was better in detecting intracortical lesions in comparison with 7T T2(   ), 7T MPRAGE, and 3T 3D @entity17367 . since only a very few intracortical lesions were detected in healthy controls in our blind assessment, it is likely that the lesions detected represent focal grey matter demyelination. High resolution MT imaging has especially revealed cortical changes that have not been recognised by other MR sequences. MTR maps were noisier than MPRAGE, T2(   ) and @entity17367 , but also better in localising cortical lesions. As MTR is more pathologically specific than other sequences in detecting tissue myelination, it raises the possibility that high resolution MTR will be able to demonstrate cortical remyelination in vivo.

title: Improved detection of focal cortical lesions using 7T magnetisation transfer imaging in XXXX with @entity15 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity3264 ( @entity367 ) is a taste enhancer that contributes to the characteristic flavour of foods. In fruit of @entity523 ( @entity523 .), the @entity367 content increases dramatically during the ripening process, becoming the most abundant free @entity3689 when the fruit become red. There is also a concomitant increase in @entity2125 -dependent @entity3264 dehydrogenase ( @entity71827 ) activity during the ripening transition. This enzyme is located in the mitochondria and catalyses the reversible amination of @entity15706 to @entity367 . To investigate the potential effect of @entity71827 on @entity367 metabolism, the abundance of @entity71827 was altered by artificial microRNA technology. Efficient silencing of all the endogenous SlGDH genes was achieved, leading to a dramatic decrease in total @entity71827 activity. This decrease in @entity71827 activity did not lead to any clear morphological or metabolic phenotype in leaves or green fruit. However, red fruit on the transgenic plants showed markedly reduced levels of @entity367 and a large increase in @entity5906 , @entity413 and @entity948 content in comparison to wild-type fruit. These results suggest that @entity71827 is involved in the synthesis of @entity367 in @entity523 fruit during the ripening processes. This contrasts with the biological role ascribed to @entity71827 in many other tissues and species. Overall, these findings suggest that @entity71827 has a major effect on the control of metabolic composition during @entity523 fruit ripening, but not at other stages of development.

title: Reduced levels of XXXX -dependent @entity3264 dehydrogenase decrease the @entity3264 content of ripe @entity523 fruit but have no effect on green fruit or leaves.

entities_list: @entity3264 :: ('D018698', 'Chemical') :: ['glutamate', 'Glutamate']

entities_list: @entity15706 :: ('MESH:C029743', 'Chemical') :: ['2-oxoglutarate']

entities_list: @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose']

entities_list: @entity523 :: ('4081', 'Species') :: ['Solanum lycopersicum L', 'tomato']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity2125 :: (MESH:D009243,Chemical) :: ['NADH']


abstract: @entity3264 ( @entity367 ) is a taste enhancer that contributes to the characteristic flavour of foods. In fruit of @entity523 ( @entity523 .), the @entity367 content increases dramatically during the ripening process, becoming the most abundant free @entity3689 when the fruit become red. There is also a concomitant increase in @entity2125 -dependent @entity3264 dehydrogenase ( @entity71827 ) activity during the ripening transition. This enzyme is located in the mitochondria and catalyses the reversible amination of @entity15706 to @entity367 . To investigate the potential effect of @entity71827 on @entity367 metabolism, the abundance of @entity71827 was altered by artificial microRNA technology. Efficient silencing of all the endogenous SlGDH genes was achieved, leading to a dramatic decrease in total @entity71827 activity. This decrease in @entity71827 activity did not lead to any clear morphological or metabolic phenotype in leaves or green fruit. However, red fruit on the transgenic plants showed markedly reduced levels of @entity367 and a large increase in @entity5906 , @entity413 and @entity948 content in comparison to wild-type fruit. These results suggest that @entity71827 is involved in the synthesis of @entity367 in @entity523 fruit during the ripening processes. This contrasts with the biological role ascribed to @entity71827 in many other tissues and species. Overall, these findings suggest that @entity71827 has a major effect on the control of metabolic composition during @entity523 fruit ripening, but not at other stages of development.

title: Reduced levels of @entity2125 -dependent @entity3264 dehydrogenase decrease the @entity3264 content of ripe XXXX fruit but have no effect on green fruit or leaves.

answer: @entity523 :: (4081,Species) :: ['tomato']


abstract: @entity3264 ( @entity367 ) is a taste enhancer that contributes to the characteristic flavour of foods. In fruit of @entity523 ( @entity523 .), the @entity367 content increases dramatically during the ripening process, becoming the most abundant free @entity3689 when the fruit become red. There is also a concomitant increase in @entity2125 -dependent @entity3264 dehydrogenase ( @entity71827 ) activity during the ripening transition. This enzyme is located in the mitochondria and catalyses the reversible amination of @entity15706 to @entity367 . To investigate the potential effect of @entity71827 on @entity367 metabolism, the abundance of @entity71827 was altered by artificial microRNA technology. Efficient silencing of all the endogenous SlGDH genes was achieved, leading to a dramatic decrease in total @entity71827 activity. This decrease in @entity71827 activity did not lead to any clear morphological or metabolic phenotype in leaves or green fruit. However, red fruit on the transgenic plants showed markedly reduced levels of @entity367 and a large increase in @entity5906 , @entity413 and @entity948 content in comparison to wild-type fruit. These results suggest that @entity71827 is involved in the synthesis of @entity367 in @entity523 fruit during the ripening processes. This contrasts with the biological role ascribed to @entity71827 in many other tissues and species. Overall, these findings suggest that @entity71827 has a major effect on the control of metabolic composition during @entity523 fruit ripening, but not at other stages of development.

title: Reduced levels of @entity2125 -dependent XXXX dehydrogenase decrease the @entity3264 content of ripe @entity523 fruit but have no effect on green fruit or leaves.

answer: @entity3264 :: (D018698,Chemical) :: ['glutamate']


abstract: @entity3264 ( @entity367 ) is a taste enhancer that contributes to the characteristic flavour of foods. In fruit of @entity523 ( @entity523 .), the @entity367 content increases dramatically during the ripening process, becoming the most abundant free @entity3689 when the fruit become red. There is also a concomitant increase in @entity2125 -dependent @entity3264 dehydrogenase ( @entity71827 ) activity during the ripening transition. This enzyme is located in the mitochondria and catalyses the reversible amination of @entity15706 to @entity367 . To investigate the potential effect of @entity71827 on @entity367 metabolism, the abundance of @entity71827 was altered by artificial microRNA technology. Efficient silencing of all the endogenous SlGDH genes was achieved, leading to a dramatic decrease in total @entity71827 activity. This decrease in @entity71827 activity did not lead to any clear morphological or metabolic phenotype in leaves or green fruit. However, red fruit on the transgenic plants showed markedly reduced levels of @entity367 and a large increase in @entity5906 , @entity413 and @entity948 content in comparison to wild-type fruit. These results suggest that @entity71827 is involved in the synthesis of @entity367 in @entity523 fruit during the ripening processes. This contrasts with the biological role ascribed to @entity71827 in many other tissues and species. Overall, these findings suggest that @entity71827 has a major effect on the control of metabolic composition during @entity523 fruit ripening, but not at other stages of development.

title: Reduced levels of @entity2125 -dependent @entity3264 dehydrogenase decrease the XXXX content of ripe @entity523 fruit but have no effect on green fruit or leaves.

answer: @entity3264 :: (D018698,Chemical) :: ['glutamate']


abstract: AIM: The differentiation between @entity99 ( @entity99 ) and @entity2876 ( @entity2876 ) is not always possible despite all the currently available diagnostic modalities. In this study, an attempt has been made to evaluate the role of @entity842 (NO) levels in the peripheral blood to differentiate between the two conditions, one requiring early surgical intervention ( @entity2876 ) and the other amenable to conservative medical management ( @entity99 ). @entity1 AND METHODS: Twenty @entity1 who presented to the pediatric surgical service, over a 2 years period, with features of @entity1448 were enrolled in the study. The diagnostic workup included documentation of history and clinical examination, biochemical liver function tests, ultrasonography, hepatobiliary scintigraphy (HS), and magnetic resonance cholangio-pancreaticography (MRCP). These @entity1 did not show excretion on HS and intrahepatic ducts on MRCP. Hence, they were subjected to mini-laparotomy and operative cholangiography (OC). The @entity2876 @entity1 were treated with the Kasai's portoenterostomy procedure, and the extrahepatic ducts were flushed with normal saline in @entity99 @entity1 . All @entity1 were evaluated preoperatively for levels of NO in the peripheral blood by the Greiss reaction spectrophotometrically at 540 nm. Normal values were determined from a cohort of controls. The median (range) levels of NO in @entity1 with @entity2876 and @entity99 were compared, and the statistical significance of the difference was calculated by applying the Wilcox Rank Sum test. A P = 0.05 was considered as significant. RESULTS: Of the 20 @entity1 enrolled in the study, 17 @entity1 were treated for @entity2876 (Group I) and the remaining 3 @entity1 had patent ducts on OC and were thus diagnosed as @entity99 (Group II). The mean age of the @entity1 in Groups I and II was comparable: 2.79    0.75 and 2.67    0.58 months, respectively (P = 0.866). The median NO levels were significantly elevated in each of the two groups as compared to the controls (5.6  mol/l, range 1.26-11.34  mol/l); when compared among themselves, the NO levels were significantly higher in Group I, 64.05  mol/l (range 24.11-89.43  mol/l), when compared with Group II, 41.72  mol/l (range 23.53-45.63  mol/l) (P = 0.022). CONCLUSION: The serum levels of NO were found to be significantly higher in @entity1 with @entity2876 as compared to those with @entity99 . Hence, this may be a useful biochemical marker for the preoperative differentiation of @entity2876 from @entity99 . However, a larger study is required for establishing the validity of the statistical significance.

title: Evaluation of blood levels of @entity842 as a means of differentiation between XXXX and @entity2876 : A pilot study.

entities_list: @entity1448 :: ('MESH:D002779', 'Disease') :: ['neonatal cholestasis']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity2876 :: ('MESH:D001656', 'Disease') :: ['EHBA', 'extrahepatic biliary atresia']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['NH', 'neonatal hepatitis']

answer: @entity99 :: (MESH:D056486,Disease) :: ['neonatal hepatitis']


abstract: AIM: The differentiation between @entity99 ( @entity99 ) and @entity2876 ( @entity2876 ) is not always possible despite all the currently available diagnostic modalities. In this study, an attempt has been made to evaluate the role of @entity842 (NO) levels in the peripheral blood to differentiate between the two conditions, one requiring early surgical intervention ( @entity2876 ) and the other amenable to conservative medical management ( @entity99 ). @entity1 AND METHODS: Twenty @entity1 who presented to the pediatric surgical service, over a 2 years period, with features of @entity1448 were enrolled in the study. The diagnostic workup included documentation of history and clinical examination, biochemical liver function tests, ultrasonography, hepatobiliary scintigraphy (HS), and magnetic resonance cholangio-pancreaticography (MRCP). These @entity1 did not show excretion on HS and intrahepatic ducts on MRCP. Hence, they were subjected to mini-laparotomy and operative cholangiography (OC). The @entity2876 @entity1 were treated with the Kasai's portoenterostomy procedure, and the extrahepatic ducts were flushed with normal saline in @entity99 @entity1 . All @entity1 were evaluated preoperatively for levels of NO in the peripheral blood by the Greiss reaction spectrophotometrically at 540 nm. Normal values were determined from a cohort of controls. The median (range) levels of NO in @entity1 with @entity2876 and @entity99 were compared, and the statistical significance of the difference was calculated by applying the Wilcox Rank Sum test. A P = 0.05 was considered as significant. RESULTS: Of the 20 @entity1 enrolled in the study, 17 @entity1 were treated for @entity2876 (Group I) and the remaining 3 @entity1 had patent ducts on OC and were thus diagnosed as @entity99 (Group II). The mean age of the @entity1 in Groups I and II was comparable: 2.79    0.75 and 2.67    0.58 months, respectively (P = 0.866). The median NO levels were significantly elevated in each of the two groups as compared to the controls (5.6  mol/l, range 1.26-11.34  mol/l); when compared among themselves, the NO levels were significantly higher in Group I, 64.05  mol/l (range 24.11-89.43  mol/l), when compared with Group II, 41.72  mol/l (range 23.53-45.63  mol/l) (P = 0.022). CONCLUSION: The serum levels of NO were found to be significantly higher in @entity1 with @entity2876 as compared to those with @entity99 . Hence, this may be a useful biochemical marker for the preoperative differentiation of @entity2876 from @entity99 . However, a larger study is required for establishing the validity of the statistical significance.

title: Evaluation of blood levels of @entity842 as a means of differentiation between @entity99 and XXXX : A pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

answer: @entity2876 :: (MESH:D001656,Disease) :: ['extrahepatic biliary atresia']


abstract: AIM: The differentiation between @entity99 ( @entity99 ) and @entity2876 ( @entity2876 ) is not always possible despite all the currently available diagnostic modalities. In this study, an attempt has been made to evaluate the role of @entity842 (NO) levels in the peripheral blood to differentiate between the two conditions, one requiring early surgical intervention ( @entity2876 ) and the other amenable to conservative medical management ( @entity99 ). @entity1 AND METHODS: Twenty @entity1 who presented to the pediatric surgical service, over a 2 years period, with features of @entity1448 were enrolled in the study. The diagnostic workup included documentation of history and clinical examination, biochemical liver function tests, ultrasonography, hepatobiliary scintigraphy (HS), and magnetic resonance cholangio-pancreaticography (MRCP). These @entity1 did not show excretion on HS and intrahepatic ducts on MRCP. Hence, they were subjected to mini-laparotomy and operative cholangiography (OC). The @entity2876 @entity1 were treated with the Kasai's portoenterostomy procedure, and the extrahepatic ducts were flushed with normal saline in @entity99 @entity1 . All @entity1 were evaluated preoperatively for levels of NO in the peripheral blood by the Greiss reaction spectrophotometrically at 540 nm. Normal values were determined from a cohort of controls. The median (range) levels of NO in @entity1 with @entity2876 and @entity99 were compared, and the statistical significance of the difference was calculated by applying the Wilcox Rank Sum test. A P = 0.05 was considered as significant. RESULTS: Of the 20 @entity1 enrolled in the study, 17 @entity1 were treated for @entity2876 (Group I) and the remaining 3 @entity1 had patent ducts on OC and were thus diagnosed as @entity99 (Group II). The mean age of the @entity1 in Groups I and II was comparable: 2.79    0.75 and 2.67    0.58 months, respectively (P = 0.866). The median NO levels were significantly elevated in each of the two groups as compared to the controls (5.6  mol/l, range 1.26-11.34  mol/l); when compared among themselves, the NO levels were significantly higher in Group I, 64.05  mol/l (range 24.11-89.43  mol/l), when compared with Group II, 41.72  mol/l (range 23.53-45.63  mol/l) (P = 0.022). CONCLUSION: The serum levels of NO were found to be significantly higher in @entity1 with @entity2876 as compared to those with @entity99 . Hence, this may be a useful biochemical marker for the preoperative differentiation of @entity2876 from @entity99 . However, a larger study is required for establishing the validity of the statistical significance.

title: Evaluation of blood levels of XXXX as a means of differentiation between @entity99 and @entity2876 : A pilot study.

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: AIM: To investigate whether expression of selected miRNAs obtained from fibrotic liver biopsies correlate with @entity82 stage. METHODS: Altogether, 52 @entity1 were enrolled in the study representing various etiologic backgrounds of @entity82 : 24 cases with @entity3619 (types B, C), 19 with @entity409 ( @entity775 , @entity2835 , @entity991 , @entity3928 cases), and 9 of mixed etiology (alcoholic and nonalcoholic @entity1560 , cryptogenic cases). Severity of @entity82 was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNA isolation, expression levels of @entity10017 , @entity2853 , @entity15453 , @entity494 , @entity10074 , and @entity14908 were determined using TaqMan MicroRNA Assays applying @entity31219 as the reference. Selection of miRNAs was based on their characteristic up- or downregulation observed in @entity157 . Relative expression of miRNAs was correlated with @entity82 stage and @entity409 ( @entity409 ) value measured by transient elastography, as well as with serum @entity3929 aminotransferase (ALT) level. RESULTS: The expression of individual miRNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of @entity2853 in stage F4 was statistically significant (P < 0.04). When analyzing miRNA expression in relation to @entity82 , levels of @entity2853 and @entity494 showed negative correlations with @entity82 stage, and @entity2853 was found to correlate negatively and @entity14908 positively with @entity409 values (all P < 0.05). ALT levels displayed a positive correlation with @entity10017 (P < 0.04). Negative correlations were observed in the @entity82 samples of mixed etiology between @entity2853 and @entity82 stage and @entity409 values (P < 0.05), and in the samples of chronic @entity99 , between @entity494 and @entity82 stage (P < 0.01), whereas @entity10017 showed positive correlation with ALT values in the samples of @entity409 (P < 0.03). The results also revealed a strong correlation between @entity82 stage and @entity409 values (P < 0.01) when etiology of @entity82 was not taken into account. CONCLUSION: Reduced expression of @entity2853 in advanced @entity82 and its correlation with @entity82 stage and @entity409 values seem to be characteristic of @entity1575 of various etiologies.

title: XXXX negatively correlates with @entity1575 as detected by histology and FibroScan.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2835 :: ('MESH:D008105', 'Disease') :: ['primary biliary cirrhosis']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatosis']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis']

entities_list: @entity3928 :: ('MESH:C536030', 'Disease') :: ['overlapping syndrome']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['autoimmune liver diseases', 'LS', 'liver stiffness']

entities_list: @entity991 :: ('MESH:D015209', 'Disease') :: ['primary sclerosing cholangitis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

entities_list: @entity3619 :: ('MESH:D006521', 'Disease') :: ['chronic hepatitis infections']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['viral hepatitis']

entities_list: @entity775 :: ('MESH:D019693', 'Disease') :: ['autoimmune hepatitis']

answer: @entity2853 :: (406906,Gene) :: ['miR-122']


abstract: AIM: To investigate whether expression of selected miRNAs obtained from fibrotic liver biopsies correlate with @entity82 stage. METHODS: Altogether, 52 @entity1 were enrolled in the study representing various etiologic backgrounds of @entity82 : 24 cases with @entity3619 (types B, C), 19 with @entity409 ( @entity775 , @entity2835 , @entity991 , @entity3928 cases), and 9 of mixed etiology (alcoholic and nonalcoholic @entity1560 , cryptogenic cases). Severity of @entity82 was determined by both histologic staging using the METAVIR scoring system and noninvasive transient elastography. Following RNA isolation, expression levels of @entity10017 , @entity2853 , @entity15453 , @entity494 , @entity10074 , and @entity14908 were determined using TaqMan MicroRNA Assays applying @entity31219 as the reference. Selection of miRNAs was based on their characteristic up- or downregulation observed in @entity157 . Relative expression of miRNAs was correlated with @entity82 stage and @entity409 ( @entity409 ) value measured by transient elastography, as well as with serum @entity3929 aminotransferase (ALT) level. RESULTS: The expression of individual miRNAs showed deregulated patterns in stages F1-F4 as compared with stage F0, but only the reduced level of @entity2853 in stage F4 was statistically significant (P < 0.04). When analyzing miRNA expression in relation to @entity82 , levels of @entity2853 and @entity494 showed negative correlations with @entity82 stage, and @entity2853 was found to correlate negatively and @entity14908 positively with @entity409 values (all P < 0.05). ALT levels displayed a positive correlation with @entity10017 (P < 0.04). Negative correlations were observed in the @entity82 samples of mixed etiology between @entity2853 and @entity82 stage and @entity409 values (P < 0.05), and in the samples of chronic @entity99 , between @entity494 and @entity82 stage (P < 0.01), whereas @entity10017 showed positive correlation with ALT values in the samples of @entity409 (P < 0.03). The results also revealed a strong correlation between @entity82 stage and @entity409 values (P < 0.01) when etiology of @entity82 was not taken into account. CONCLUSION: Reduced expression of @entity2853 in advanced @entity82 and its correlation with @entity82 stage and @entity409 values seem to be characteristic of @entity1575 of various etiologies.

title: @entity2853 negatively correlates with XXXX as detected by histology and FibroScan.

answer: @entity1575 :: (MESH:D008103,Disease) :: ['liver fibrosis']


abstract: The present study was conducted to examine whether heat-processed Scutellariae Radix has an ameliorative effect on lipopolysaccharide- ( @entity558 -) induced @entity647 in @entity19 . The effects of Scutellariae Radix heat-processed at 160  C ( @entity27736 ) were compared with those of nonheat-processed Scutellariae Radix (NSR). The @entity558 -treated group displayed a markedly decreased body weight and significantly increased lung weight; however, the administration of NSR or @entity27736 improved both the body and lung weights. The increased oxidative stress and inflammatory biomarker levels in the serum and lung were reduced significantly with @entity27736 . The reduced @entity224 dismutase and @entity5533 increased significantly by both NSR and @entity27736 . Also, the dysregulated oxidative stress and @entity32 were significantly ameliorated by NSR and @entity27736 . The expression of inflammatory mediators and cytokines by nuclear factor-kappa B activation was modulated through inhibition of a nuclear factor kappa Ba degradation. Also, lung histological change was markedly suppressed by @entity27736 rather than NSR. Overall, the ameliorative effects of @entity27736 were superior to those when being nonheat-processed. The representative @entity3096 contents of Scutellariae Radix that include @entity7651 , @entity19988 , and @entity42095 were greater by heat process. These data reveal heat-processed Scutellariae Radix may be a critical factor involved in the improvement of @entity358 caused by @entity558 .

title: Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced XXXX in @entity19 via NF- k B Signaling.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity19988 :: ('MESH:C006680', 'Chemical') :: ['baicalein']

entities_list: @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid']

entities_list: @entity7651 :: ('MESH:C038044', 'Chemical') :: ['baicalin']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disorders']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury']

answer: @entity647 :: (MESH:D055371,Disease) :: ['Acute Lung Injury']


abstract: The present study was conducted to examine whether heat-processed Scutellariae Radix has an ameliorative effect on lipopolysaccharide- ( @entity558 -) induced @entity647 in @entity19 . The effects of Scutellariae Radix heat-processed at 160  C ( @entity27736 ) were compared with those of nonheat-processed Scutellariae Radix (NSR). The @entity558 -treated group displayed a markedly decreased body weight and significantly increased lung weight; however, the administration of NSR or @entity27736 improved both the body and lung weights. The increased oxidative stress and inflammatory biomarker levels in the serum and lung were reduced significantly with @entity27736 . The reduced @entity224 dismutase and @entity5533 increased significantly by both NSR and @entity27736 . Also, the dysregulated oxidative stress and @entity32 were significantly ameliorated by NSR and @entity27736 . The expression of inflammatory mediators and cytokines by nuclear factor-kappa B activation was modulated through inhibition of a nuclear factor kappa Ba degradation. Also, lung histological change was markedly suppressed by @entity27736 rather than NSR. Overall, the ameliorative effects of @entity27736 were superior to those when being nonheat-processed. The representative @entity3096 contents of Scutellariae Radix that include @entity7651 , @entity19988 , and @entity42095 were greater by heat process. These data reveal heat-processed Scutellariae Radix may be a critical factor involved in the improvement of @entity358 caused by @entity558 .

title: Heat-Processed Scutellariae Radix Enhances Anti-Inflammatory Effect against Lipopolysaccharide-Induced @entity647 in XXXX via NF- k B Signaling.

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: BACKGROUND: @entity1148 can follow surgery and has occasionally been observed after major orthopaedic surgery. The aim of the present study was to ascertain the platelet count (PLTC) change in @entity1 admitted to a rehabilitation unit after major joint surgery and whether @entity1150 ( @entity1150 ) and poor outcomes occurred in those who had @entity1148 . METHOD: PLTC, red blood cells (RBC), haemoglobin (Hb), @entity2002 , and D-dimers were assessed in @entity1 on admission and at discharge after major joint surgery. Functional outcomes were ascertained using the Barthel Scale (BS), the Functional Independence Measure (FIM) and gait evaluation. @entity1148 was considered to have occurred when PLTC was greater than or equal to 500 * 100(9)/L. All subjects with @entity1148 had ultrasonography to assess @entity1150 occurrence. The @entity1 were divided into "young" and "old" groups according to an age cut-off of 75  years to investigate potential age-related differences. RESULTS: Two hundred and seventy-five @entity1 were identified and 142 (36  M and 106  F, mean age 77.2        10.7) were enrolled. Seventy-six (53.5%) underwent total hip arthroplasty (THA), 40 (51.1%) underwent hip internal fixation and 26 (18.3%) subjects underwent total knee arthroplasty (TKA). The young and old groups included 60 and 82 @entity1 , respectively. Fifty-nine (42.4%) @entity1 had PLTC above 400 * 100(9)/L. Of these, 28 (20.1%) had @entity1148 with PLTC above 500 * 100(9)/L, and 15 of them (10.7%) had very high values above 600 * 100(9)/L. Increased levels of @entity2002 and D-dimers were also detected. No subject with @entity1148 had @entity1150 . Outcome was not affected by PLTC. At discharge, significant improvement in all functional assessments was observed in young compared to old @entity1 ; gait: 2.9        0.2 vs. 2.2        0.8; BS: 97        6.9 vs. 70.5        25.6; and FIM: 116.4        10.9 vs. 83.6        31.2 (p   <   0.004), respectively. BS and FIM mean scores were positively correlated with Hb level. CONCLUSION: Elevated PLTC and @entity1148 were not uncommon in @entity1 after major joint surgery, but no subject developed @entity1150 . Platelet count change did not affect the outcome. Higher age and lower haemoglobin level correlated with poorer functional recovery.

title: XXXX after hip and knee surgery in the rehabilitation setting: is it an occasional phenomenon? Relationship with @entity1150 and functional outcome.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis', 'DVT']

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['Thrombocytosis', 'thrombocytosis']

answer: @entity1148 :: (MESH:D013922,Disease) :: ['Thrombocytosis']


abstract: BACKGROUND: @entity1148 can follow surgery and has occasionally been observed after major orthopaedic surgery. The aim of the present study was to ascertain the platelet count (PLTC) change in @entity1 admitted to a rehabilitation unit after major joint surgery and whether @entity1150 ( @entity1150 ) and poor outcomes occurred in those who had @entity1148 . METHOD: PLTC, red blood cells (RBC), haemoglobin (Hb), @entity2002 , and D-dimers were assessed in @entity1 on admission and at discharge after major joint surgery. Functional outcomes were ascertained using the Barthel Scale (BS), the Functional Independence Measure (FIM) and gait evaluation. @entity1148 was considered to have occurred when PLTC was greater than or equal to 500 * 100(9)/L. All subjects with @entity1148 had ultrasonography to assess @entity1150 occurrence. The @entity1 were divided into "young" and "old" groups according to an age cut-off of 75  years to investigate potential age-related differences. RESULTS: Two hundred and seventy-five @entity1 were identified and 142 (36  M and 106  F, mean age 77.2        10.7) were enrolled. Seventy-six (53.5%) underwent total hip arthroplasty (THA), 40 (51.1%) underwent hip internal fixation and 26 (18.3%) subjects underwent total knee arthroplasty (TKA). The young and old groups included 60 and 82 @entity1 , respectively. Fifty-nine (42.4%) @entity1 had PLTC above 400 * 100(9)/L. Of these, 28 (20.1%) had @entity1148 with PLTC above 500 * 100(9)/L, and 15 of them (10.7%) had very high values above 600 * 100(9)/L. Increased levels of @entity2002 and D-dimers were also detected. No subject with @entity1148 had @entity1150 . Outcome was not affected by PLTC. At discharge, significant improvement in all functional assessments was observed in young compared to old @entity1 ; gait: 2.9        0.2 vs. 2.2        0.8; BS: 97        6.9 vs. 70.5        25.6; and FIM: 116.4        10.9 vs. 83.6        31.2 (p   <   0.004), respectively. BS and FIM mean scores were positively correlated with Hb level. CONCLUSION: Elevated PLTC and @entity1148 were not uncommon in @entity1 after major joint surgery, but no subject developed @entity1150 . Platelet count change did not affect the outcome. Higher age and lower haemoglobin level correlated with poorer functional recovery.

title: @entity1148 after hip and knee surgery in the rehabilitation setting: is it an occasional phenomenon? Relationship with XXXX and functional outcome.

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep venous thrombosis']


abstract: BACKGROUND: Findings on the demographic and sexual health characteristics associated with the experience of a crisis pregnancy are important to inform the public health policy of a country, including Ireland. Studies from other jurisdictions have suggested that certain demographic groups are at risk for unintended pregnancies and the disparity between the groups has been growing in recent years. Ireland is a country which experienced much economic and societal change in the first decade of the 21(st) century; changes which are likely to have affected demographic variables pertaining to sexual health. The current study had two aims: to investigate changes in the socioeconomic characteristics associated with crisis pregnancies over a seven year period [2003 to 2010], and to investigate the recent [2010] socioeconomic risk factors associated with crisis pregnancies in Ireland. METHODS: The study compared the results from 18-45 year old @entity1 using data from three broadly similar nationally representative Irish @entity458 carried out in 2003, 2004-2006 and 2010. Chi square analysis compared of the socioeconomic characteristics across the seven year period. A logistic regression then investigated the sexual health history and socioeconomic factors associated with the experience of a recent crisis pregnancy using the most recent 2010 data. RESULTS: In 2010, 74% of @entity1 experienced parenthood and 23% experienced abortion as the outcome of their crisis pregnancy. Receipt of sex education and contraception use at first sex significantly predicted the experiencing of a recent crisis pregnancy. Younger @entity1 and those with a lower level of education were more likely to report having experienced a recent crisis pregnancy. CONCLUSION: Similar demographic groups are at risk for experiencing a crisis pregnancy in Ireland compared with international research, yet the disparities between demographic groups who have experienced a crisis pregnancy appear to be decreasing rather than increasing over a seven year period. Recommendations are made with regard to the provision of continued sex education throughout the lifespan, particularly for those @entity1 who are at an increased risk of experiencing a crisis pregnancy.

title: Factors associated with crisis pregnancies in Ireland: findings from three nationally representative XXXX .

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual health surveys']

answer: @entity458 :: (MESH:D020018,Disease) :: ['sexual health surveys']


abstract: @entity191 ( @entity191 ) leads to impairment in multiple cognitive domains. Micrographia is a relatively early @entity191 , characterized by a global reduction in writing size and a decrement in size during writing. Here we aimed to investigate the effect of @entity227 on writing size in @entity1 with @entity191 . Twenty-five @entity1 with @entity191 without @entity73 and twenty-five age-matched controls had to write a standard sentence with and without @entity227 . We assessed the effect of @entity227 by measuring vertical word size (i), horizontal length of the sentence (ii), and the summed horizontal word length without interspacing (iii), comparing @entity1 with controls. In both @entity1 and controls, writing was significantly larger without @entity227 . This enlargement did not significantly differ between the groups. Smaller handwriting significantly correlated with @entity66 severity. Contrary to previous observations that @entity227 caused increased writing size in specifically @entity191 , we did not find differences between @entity1 and controls. Both groups wrote larger without @entity227 , which adds insight in general neuronal mechanisms underlying the balance between feed-forward and feedback in visuomotor control, mechanisms that also hold for grasping movements.

title: The Effect of Visual Feedback on Writing Size in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['withdrawal of visual feedback', 'visual feedback']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['increased disease']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive dysfunction']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'non-tremor-dominant PD', 'PD sign of visuomotor dysfunction', 'PD']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's Disease']


abstract: AIM: The appropriate additional surgery after non-curative resection of Endoscopic Mucosal Resection (ESD) for early @entity356 is herein discussed. @entity1 AND METHODS: Data on 54 @entity1 after non-curative resection of ESD were evaluated. These @entity1 were broadly classified according to the risk of lymph node @entity3 with lesions into group A (without risk) (n=26) and group B (with risk) (n=28). Their treatment results were evaluated. RESULTS: The incidence of residual lesion was 7.7% in group A and 14.3% in group B. Risk factors were piecemeal resection, involvement of the horizontal margin ( @entity19291 ) or unclear involvement of the horizontal margin (HMX) and with @entity1066 . Lymph node @entity3 was detected in one @entity1 with lymphatic invasion, total diameter of 3 cm or more and submucosal invasion over 0.5 mm ( @entity3578 ). The 5-year survival rate was 93% and none of the @entity1 died of @entity356 . CONCLUSION: Follow-up observation was reasonable in group A. @entity1 who are judged as having undergone piecemeal resection, @entity19291 or HMX and with @entity1066 , should be treated by additional surgery and @entity1 judged with @entity3578 or total diameter of 3 cm or more or lymphatic invasion should be treated by additional surgery with lymphadectomy in groupB.

title: Additional Surgery After Non-curative Resection of ESD for Early XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']


abstract: BACKGROUND/AIM: @entity1 with @entity2 often develop a @entity5474 after treatment of the initial @entity5 . In those cases, it is difficult to distinguish @entity2 ( @entity2 ) from lung metastasis. Therefore, both local therapy for a single lung lesions and systemic therapy for micrometastases are needed. This retrospective study aimed to evaluate the safety and tolerability of concurrent stereotactic body radiation therapy (SBRT) and chemotherapy in @entity1 with metachronous @entity2 . @entity1 AND METHODS: We reviewed the records of 10 @entity1 with metachronous @entity2 treated with SBRT and concurrent chemotherapy with curative intent from 2007 to 2013. The delivered radiation dose was 48 Gy in four fractions. RESULTS: All @entity1 received SBRT with concurrent chemotherapy on schedule. Complete response rate was 90%. Safety profile of this treatment was compatible with that of traditional chemoradiotherapy. CONCLUSION: Our study showed good feasibility and safety for SBRT with concurrent chemoradiotherapy.

title: A new strategy for metachronous XXXX : stereotactic body radiation therapy with concurrent chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['primary lung cancer', 'malignant lung cancer', 'PLC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity5474 :: ('MESH:D003074', 'Disease') :: ['solitary pulmonary nodule']

answer: @entity2 :: (MESH:D008175,Disease) :: ['primary lung cancer']


abstract: PURPOSE: @entity12740 ( @entity12740 ) are the perceptions that @entity1 have about their overall worth and capability. @entity12740 may be a useful global indicator of adaptation to disability and subjective well-being. The Core Self-Evaluations Scale (CSES) is the most common direct measure of @entity12740 , but its use with @entity1 with disabilities has not been validated. This study aims to evaluate the factorial and concurrent validity of the CSES in @entity1 with @entity1566 . METHOD: Two hundred forty-seven individuals with @entity1566 completed an online survey consisting of the CSES, measures of the four @entity12740 traits, and selected psychosocial variables. RESULTS: Confirmatory factor analysis results provide support for the one-factor measurement structure of the CSES. When correlated with selected psychosocial variables, the CSES was found to perform in a similar fashion to an indirect measure of @entity12740 constructed from measures of the individual @entity12740 traits. CONCLUSIONS: The CSES demonstrated acceptable psychometric properties, and its use as a brief, cost-effective measure of @entity12740 in rehabilitation research and practice is supported. Implications for Rehabilitation @entity12740 ( @entity12740 ) are the perceptions that @entity1 have about their overall worth and capability, and the construct has promise as a global indicator of adaptation to disability and subjective well-being in rehabilitation research and practice. The Core Self-Evaluations Scale (CSES) is a brief, valuable and cost-effective instrument that can be easily used in both rehabilitation research and practice and has the potential to reduce burden associated with client/ @entity1 assessment. This study provided evidence of the factorial and concurrent validity of the CSES in @entity1 with @entity1566 , and supports its use in rehabilitation settings.

title: Psychometric validation of the Core Self-Evaluations Scale in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participant', 'people', 'persons']

entities_list: @entity12740 :: ('MESH:D020512', 'Disease') :: ['Core self-evaluations', 'CSE']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: PURPOSE: @entity12740 ( @entity12740 ) are the perceptions that @entity1 have about their overall worth and capability. @entity12740 may be a useful global indicator of adaptation to disability and subjective well-being. The Core Self-Evaluations Scale (CSES) is the most common direct measure of @entity12740 , but its use with @entity1 with disabilities has not been validated. This study aims to evaluate the factorial and concurrent validity of the CSES in @entity1 with @entity1566 . METHOD: Two hundred forty-seven individuals with @entity1566 completed an online survey consisting of the CSES, measures of the four @entity12740 traits, and selected psychosocial variables. RESULTS: Confirmatory factor analysis results provide support for the one-factor measurement structure of the CSES. When correlated with selected psychosocial variables, the CSES was found to perform in a similar fashion to an indirect measure of @entity12740 constructed from measures of the individual @entity12740 traits. CONCLUSIONS: The CSES demonstrated acceptable psychometric properties, and its use as a brief, cost-effective measure of @entity12740 in rehabilitation research and practice is supported. Implications for Rehabilitation @entity12740 ( @entity12740 ) are the perceptions that @entity1 have about their overall worth and capability, and the construct has promise as a global indicator of adaptation to disability and subjective well-being in rehabilitation research and practice. The Core Self-Evaluations Scale (CSES) is a brief, valuable and cost-effective instrument that can be easily used in both rehabilitation research and practice and has the potential to reduce burden associated with client/ @entity1 assessment. This study provided evidence of the factorial and concurrent validity of the CSES in @entity1 with @entity1566 , and supports its use in rehabilitation settings.

title: Psychometric validation of the Core Self-Evaluations Scale in XXXX with @entity1566 .

answer: @entity1 :: (9606,Species) :: ['people']


abstract: PURPOSE: The main objective of this study was to optimize @entity205 ( @entity9472 ) nanomicellar solution and study in vivo ocular @entity9472 tissue distribution with a topical drop. METHODS: An optimized blend of hydrogenated castor oil-40 and @entity6000 -40 was prepared to entrap @entity9472 within nanomicelles. In vivo studies were conducted in New Zealand White albino @entity95 with topical drop instillation. RESULTS: Average size of @entity9472 -loaded nanomicelles was approximately 22.4 nm. Ocular tissue @entity9472 quantification with single and multiple dosing revealed that @entity9472 levels followed as @entity267  >  iris-ciliary body  >  aqueous humor  >  lens. @entity205 levels were also found to be in the following order: conjunctiva  >  sclera  >  retina/choroid  >  vitreous humor. High @entity9472 level was detected in retina/choroid (53.7 ng/g tissue). CONCLUSIONS: Ocular tissue @entity9472 distribution studies revealed high @entity9472 concentrations in anterior ocular tissues. Moreover, it appears that nanomicelles are transported through a conjunctival-scleral pathway and deliver @entity9472 to the retina/choroid. Results suggest polymeric blend to be a safe carrier for anterior and posterior ocular tissues. TRANSLATIONAL RELEVANCE: This study has significant translational relevance, disclosing results that suggest that aqueous nanomicellar approach can provide high corneal and conjunctival @entity9472 concentrations. Aqueous nanomicelles can deliver high drug concentrations not only to anterior but also to back of the eye tissues, including retina. This article provides a platform for noninvasive back of the eye drug delivery with topical eye drops. Aqueous @entity9472 nanomicelles have no perceptible @entity137 such as cell membrane damage or @entity137 to corneal and retinal pigment epithelial cells. Clear aqueous nanomicellar solution can be translated to @entity1 conditions for @entity9849 sicca and other anti-inflammatory conditions.

title: Topical, Aqueous, Clear XXXX Formulation Design for Anterior and Posterior Ocular Delivery.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity']

entities_list: @entity6000 :: ('MESH:D017830', 'Chemical') :: ['octoxynol']

entities_list: @entity9849 :: ('MESH:D007637', 'Disease') :: ['keratoconjunctivitis']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['Cyclosporine', 'cyclosporine']

answer: @entity205 :: (MESH:D016572,Chemical) :: ['Cyclosporine']


abstract: BACKGROUND: Older African Americans carry a disproportionate share of @entity102 . The purpose of this study was to identify the characteristics of urban-dwelling African Americans with @entity102 participating in @entity102 Self-Management Education (CDSME) programs and to examine factors related to successful program completion (i.e., attending at least four of the six sessions). METHODS: Data were analyzed from 11,895 African Americans who attended a CDSME program at one of the five leading delivery sites (i.e., senior center, health care organization, residential facility, community location, faith-based organization). Logistic regression analyses were used to assess the associations of demographic, delivery site, and neighborhood characteristics with CDSME program successful completion. RESULTS: Approximately, half of the African American @entity1 were aged 65-79   years, 83% were female, and 92% lived alone. Approximately, 44% of @entity1 had three or more chronic conditions and 35% resided in an impoverished area (i.e., 200% below federal poverty level). Successful completion of the CDSME program was associated with being between the ages of 50-64 and 65-79   years, being female, living alone, living in an impoverished community, and attending a CDSME program at a residential facility or community center. CONCLUSION: Findings highlight the unique patterns of attendance and delivery within the context of self-management interventions among this unique and traditionally underserved target population. Understanding such patterns can inform policy and practice efforts to engage more organizations in urban areas to increase CDSME program adoption. Particularly, employing strategies to implement CDSME programs across all delivery site types may increase reach to African American @entity1 .

title: XXXX Self-Management Education (CDSME) Program Delivery and Attendance among Urban-Dwelling African Americans.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic Disease', 'chronic disease', 'chronic diseases']

answer: @entity102 :: (MESH:D002908,Disease) :: ['Chronic Disease']


abstract: Disease management is becoming increasingly important in workplace health promotion given the aging workforce, rising @entity102 prevalence, and needs to maintain a productive and competitive American workforce. Despite the widespread availability of the @entity102 Self-Management Program (CDSMP), and its known health-related benefits, program adoption remains low in workplace settings. The primary purpose of this study is to compare personal and delivery characteristics of adults who attended CDSMP in the workplace relative to other settings (e.g., senior centers, healthcare organizations, residential facilities). This study also contrasts characteristics of CDSMP workplace @entity1 to those of the greater United States workforce and provides recommendations for translating CDSMP for use in workplace settings. Data were analyzed from 25,664 adults collected during a national dissemination of CDSMP. Only states and territories that conducted workshops in workplace settings were included in analyses (n   =   13 states and Puerto Rico). Chi-squared tests and t-tests were used to compare CDSMP @entity1 characteristics by delivery site type. CDSMP workplace @entity1 characteristics were then compared to reports from the United States Bureau of Labor Statistics. Of the 25,664 CDSMP @entity1 in this study, 1.7% (n   =   435) participated in workshops hosted in worksite settings. Compared to CDSMP @entity1 in non-workplace settings, workplace setting @entity1 were significantly younger and had fewer chronic conditions. Differences were also observed based on @entity102 types. On average, CDSMP workshops in workplace settings had smaller class sizes and workplace setting @entity1 attended more workshop sessions. CDSMP @entity1 in workplace settings were substantially older and a larger proportion were female than the general United States workforce. Findings indicate opportunities to translate CDSMP for use in the workplace to reach new target audiences.

title: XXXX self-management program in the workplace: opportunities for health improvement.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'participant']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic Disease', 'chronic disease']

answer: @entity102 :: (MESH:D002908,Disease) :: ['Chronic disease']


abstract: OBJECTIVE: To investigate the patterns and mechanisms of @entity73 associated with @entity551 . METHODS: We had consecutively recruited 16 @entity1 with @entity551 at the Neurology Center of Pusan National University Hospital for two years. Spontaneous, gaze-evoked, and positional @entity346 were recorded using 3D video-oculography in all @entity1 , and the majority of them also had pure tone audiometry and bithermal caloric tests. RESULTS: Of the 16 @entity1 , five (31.3%) reported neuro-otological symptoms along with the @entity10 while laboratory evaluation demonstrated @entity73 in ten (62.5%). Oculographic analyses documented spontaneous and/or positional @entity346 in six @entity1 (37.5%) including weak spontaneous @entity346 with positional modulation (n=4) and pure positional @entity346 (n=2). One @entity1 presented with recurrent spontaneous vertigo and @entity392 mimicking @entity9303 , and showed unidirectional horizontal and torsional @entity346 with normal head impulse tests during the attacks. Bithermal caloric tests were normal in all nine @entity1 tested. Audiometry showed unilateral (n=6) or bilateral (n=1) @entity1274 in seven (53.8%) of the 13 @entity1 tested. CONCLUSIONS: @entity551 frequently induces @entity73 . In addition to endolymphatic @entity4 and irritation of the vestibulocochlear nerve, compression or traction of the brainstem or cerebellum due to loss of @entity2841 buoyancy may be considered as a mechanism of frequent spontaneous or positional @entity346 in @entity1 with @entity551 .

title: @entity73 associated with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['audiovestibular impairments']

entities_list: @entity9303 :: ('MESH:D008575', 'Disease') :: ["Meniere's disease"]

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['hydrops']

entities_list: @entity346 :: ('MESH:D009759', 'Disease') :: ['vertical nystagmus', 'nystagmus']

entities_list: @entity392 :: ('MESH:D014012', 'Disease') :: ['tinnitus']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['orthostatic headache']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['intracranial hypotension', 'Intracranial hypotension']

answer: @entity551 :: (MESH:D007022,Disease) :: ['intracranial hypotension']


abstract: OBJECTIVE: To investigate the patterns and mechanisms of @entity73 associated with @entity551 . METHODS: We had consecutively recruited 16 @entity1 with @entity551 at the Neurology Center of Pusan National University Hospital for two years. Spontaneous, gaze-evoked, and positional @entity346 were recorded using 3D video-oculography in all @entity1 , and the majority of them also had pure tone audiometry and bithermal caloric tests. RESULTS: Of the 16 @entity1 , five (31.3%) reported neuro-otological symptoms along with the @entity10 while laboratory evaluation demonstrated @entity73 in ten (62.5%). Oculographic analyses documented spontaneous and/or positional @entity346 in six @entity1 (37.5%) including weak spontaneous @entity346 with positional modulation (n=4) and pure positional @entity346 (n=2). One @entity1 presented with recurrent spontaneous vertigo and @entity392 mimicking @entity9303 , and showed unidirectional horizontal and torsional @entity346 with normal head impulse tests during the attacks. Bithermal caloric tests were normal in all nine @entity1 tested. Audiometry showed unilateral (n=6) or bilateral (n=1) @entity1274 in seven (53.8%) of the 13 @entity1 tested. CONCLUSIONS: @entity551 frequently induces @entity73 . In addition to endolymphatic @entity4 and irritation of the vestibulocochlear nerve, compression or traction of the brainstem or cerebellum due to loss of @entity2841 buoyancy may be considered as a mechanism of frequent spontaneous or positional @entity346 in @entity1 with @entity551 .

title: XXXX associated with @entity551 .

answer: @entity73 :: (MESH:D003072,Disease) :: ['Audiovestibular impairments']


abstract: AIMS: To investigate clinicopathologic characteristics, therapeutic methods, and prognostic factors in @entity1 with synchronous primary @entity43 (SEOCs). METHODS: A retrospective review of 2 @entity5 registry databases in @entity233 was conducted to identify @entity1 diagnosed with SEOCs between January 1995 and December 2012. @entity1 with recurrent, metastatic, and metachronously occurring @entity5 were excluded. Multivariate logistic regression models were used to identify prognostic predictors for progression-free survival (PFS) and @entity1349 ( @entity1349 ). RESULTS: The analysis included 63 @entity1 with SEOCs. Seventy-six percent of the @entity1 had @entity1204 , and 60% of the @entity1 had @entity43 . Thirty-seven @entity1 (58.7%) had endometrioid/endometrioid histology. Optimal cytoreduction was obtained in 47 (74.6%) @entity1 . Recurrence developed in 17 @entity1 (27%). Multivariate analysis confirmed lymphovascular space invasion (LVSI) as an independent poor prognostic factor for @entity1349 ( @entity8604 , p = 0.045), whereas early-stage disease and optimal cytoreduction were found to be independent good prognostic factors for both PFS (OR 12.85, p<0.001 and OR 4.58, p = 0.004, respectively) and @entity1349 (OR 7.31, p = 0.002 and OR 2.95, p = 0.028, respectively). The 3- and 5-year @entity1349 rates were 74% and 69%, respectively. CONCLUSIONS: Our study demonstrated that optimal cytoreduction, early-stage disease, and LVSI are the most significant factors affecting survival in @entity1 with SEOC.

title: Synchronous primary XXXX : a multicenter review of 63 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['endometrial and ovarian cancers', 'stage I ovarian cancer']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['stage I endometrial cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity43 :: (MESH:D010051,Disease) :: ['endometrial and ovarian cancers']


abstract: UNASSIGNED: @entity4677 ( @entity29279 ) efficacy in the treatment of chorea in Huntington disease, paroxysmal nonkinesigenic dyskinesia, paroxysmal kinesigenic choreoathetosis, and dyskinetic cerebral palsy was reported in some studies. We described a case of a @entity1 with Sydenham chorea treated with @entity29279 . A 7.5-year-old male @entity1 presented with chorea, orofacial dyskinesia, speech impairment, and irritability. Echocardiographic examination revealed mitral insufficiency. Sydenham chorea was diagnosed after excluding other diseases causing chorea. Although his choreiform movements were decreased substantially with @entity1767 treatment, speech impairment, orofacial dyskinesia, and light chorea were continued. Therefore, on day 9, @entity29279 was added, and his complaints resolved in a few days. The severity of the chorea according to the Universidade Federal de Minas Gerais Sydenham's Chorea Rating Scale decreased from 47 to 5 points after @entity29279 treatment. Thus, on day 13, the dose of @entity1767 was reduced and gradually discontinued within 4 days. Symptoms did not reoccur. The follow-up at 1.5 months revealed recurrence of complaints due to discontinuation of @entity29279 by parents. Signs and symptoms were regressed completely within 1 week after @entity29279 retreatment. We suggest that @entity29279 with fewer adverse effects comparing to other drugs may be considered to be a good alternative in the treatment of Sydenham chorea.

title: A New Alternative Drug With Fewer Adverse Effects in the Treatment of Sydenham Chorea: XXXX Efficacy in a @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'child']

entities_list: @entity4677 :: ('MESH:C026098', 'Chemical') :: ['Levetiracetam']

entities_list: @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']

answer: @entity4677 :: (MESH:C026098,Chemical) :: ['Levetiracetam']


abstract: UNASSIGNED: @entity4677 ( @entity29279 ) efficacy in the treatment of chorea in Huntington disease, paroxysmal nonkinesigenic dyskinesia, paroxysmal kinesigenic choreoathetosis, and dyskinetic cerebral palsy was reported in some studies. We described a case of a @entity1 with Sydenham chorea treated with @entity29279 . A 7.5-year-old male @entity1 presented with chorea, orofacial dyskinesia, speech impairment, and irritability. Echocardiographic examination revealed mitral insufficiency. Sydenham chorea was diagnosed after excluding other diseases causing chorea. Although his choreiform movements were decreased substantially with @entity1767 treatment, speech impairment, orofacial dyskinesia, and light chorea were continued. Therefore, on day 9, @entity29279 was added, and his complaints resolved in a few days. The severity of the chorea according to the Universidade Federal de Minas Gerais Sydenham's Chorea Rating Scale decreased from 47 to 5 points after @entity29279 treatment. Thus, on day 13, the dose of @entity1767 was reduced and gradually discontinued within 4 days. Symptoms did not reoccur. The follow-up at 1.5 months revealed recurrence of complaints due to discontinuation of @entity29279 by parents. Signs and symptoms were regressed completely within 1 week after @entity29279 retreatment. We suggest that @entity29279 with fewer adverse effects comparing to other drugs may be considered to be a good alternative in the treatment of Sydenham chorea.

title: A New Alternative Drug With Fewer Adverse Effects in the Treatment of Sydenham Chorea: @entity4677 Efficacy in a XXXX .

answer: @entity1 :: (9606,Species) :: ['Child']


abstract: BACKGROUND: @entity33019 ( @entity15093 ) is a 5-hydroxytryptamine 2A and 1A receptor agonist that exhibits potent psychoactive properties in @entity1 . Recreational use of this drug has increased precipitously and is likely to result in an increase in @entity1 presenting with substance-induced psychoses. The present case provides an early example of substance-induced psychosis attributable to repeated use of @entity15093 . CASE: A 42-year-old white @entity1 , with no significant past psychiatric history, was brought to the emergency department by the police and was found to exhibit disinhibited behavior, elevated affect, disorganized thought process, and delusions of reference. Laboratory studies revealed elevated @entity1011 kinase level indicative of rhabdomyolysis. The @entity1 endorsed recent and repeated use of @entity15093 , as well as long-term Cannabis (marijuana) use. Over the course of the next 3 weeks, the @entity1 was successfully treated with @entity1089 for psychosis, @entity1092 (Depakote) for impulsivity, @entity2682 for anxiety, and @entity5774 for sleep, which resulted in the resolution of his symptoms and development of reasonable insight and judgment. Approximately 6 months after discharge, the @entity1 remained treatment compliant, as well as drug and symptom free. CONCLUSIONS: This case report illustrates an important example of substance-induced psychosis that resolved with antipsychotic treatment in a 42-year-old white @entity1 with no past psychiatric history likely attributable to the use of @entity15093 . Given the increasing use of this substance, the emergency department, primary care, and inpatient services are likely to see a significant increase in similar cases.

title: XXXX -Induced Psychosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patients', 'patient', 'man']

entities_list: @entity2682 :: ('MESH:C040029', 'Chemical') :: ['gabapentin']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['divalproex sodium']

entities_list: @entity5774 :: ('MESH:D006919', 'Chemical') :: ['hydroxyzine']

entities_list: @entity33019 :: ('MESH:D004130', 'Chemical') :: ['N,N-dimethyltryptamine']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity1089 :: ('MESH:C069541', 'Chemical') :: ['quetiapine']

answer: @entity33019 :: (MESH:D004130,Chemical) :: ['N,N-Dimethyltryptamine']


abstract: Fifty-one evaluable @entity1 with @entity1821 were reviewed. Two-thirds of the @entity1 were referred after local recurrence. One-third with primary surgery at RPMI had local recurrence rate of 31.6%. Overall, one or more local recurrences presented in 78% of @entity1 . Pulmonary metastases, occurred in 45%, while liver metastases in 13.6%. Most common primary sites were the lower extremity, followed by the retroperitoneal area and upper extremity. Median survival is better for upper and lower extremities than other areas (P less than 0.01). The medium survival was longer in the group that received radiation after resection although the difference was not statistically significant. The high rate of local recurrences suggests the adjuvant use of radiation postoperatively when the surgical margins have not been adequate. Sixteen @entity1 are alive and disease-free, with 10 of them having had five years or longer follow-up.

title: XXXX : prognosis and management.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1821 :: ('MESH:D008080', 'Disease') :: ['liposarcomas']

answer: @entity1821 :: (MESH:D008080,Disease) :: ['Liposarcomas']


abstract: @entity5229 recurs at a certain rate after thoracoscopic surgery, and risk factors for that recurrence are in question. The medical records of 248 @entity1 with @entity5229 who were followed for more than 2 years after thoracoscopic surgery were reviewed and retrospectively analyzed. Univariate and multivariate binary logistic regression analysis were used to identify possible risk factors. Twelve @entity1 experienced the recurrence of @entity5229 . @entity1 who experienced the recurrence of @entity5229 were younger than @entity1 who experienced no recurrence. A larger proportion of the @entity1 who experienced recurrence did not undergo pleurodesis. The variables age, height, weight, body mass index, duration of air leakage, and pleurodesis (performed or not) with a p value less than 0.2 in univariate analysis were entered in multivariate analysis. A younger age and not undergoing pleurodesis were associated with a higher risk of postoperative ipsilateral recurrence of @entity5229 . Not undergoing pleurodesis and a younger age are possible risk factors for recurrence of @entity5229 after thoracoscopic surgery. @entity1514 surgeons should pay more attention to pleurodesis, especially in younger @entity1 .

title: Risk factors for recurrence of XXXX after thoracoscopic surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5229 :: ('MESH:D011030', 'Disease') :: ['Primary spontaneous pneumothorax', 'primary spontaneous pneumothorax']

answer: @entity5229 :: (MESH:D011030,Disease) :: ['primary spontaneous pneumothorax']


abstract: BACKGROUND: Whether @entity28 affects surgical outcomes in @entity1 with @entity157 ( @entity157 ) is controversial. Here we retrospectively evaluated the impact of @entity28 on outcomes in @entity157 @entity1 after curative hepatectomy. METHODS: @entity1 with @entity1 -Pugh A liver function who underwent curative hepatectomy between 2006 and 2010 were categorized as @entity28 (BMI >= 25 kg/m2, n = 68) and @entity28 (<25 kg/m2, n = 242). To reduce interference from baseline differences between the two groups, propensity score-matched analysis was performed in the ratio 1:2 using a caliper width of 0.1. Surgical outcomes were compared for 61 @entity28 and 115 @entity28 @entity1 . RESULTS: @entity28 @entity1 had higher levels of albumin and @entity5906 aminotransferase, and more @entity5 compared to the @entity28 @entity1 (all P<0.05). In the propensity-matched cohort, baseline characteristics did not differ between the two groups (all P>0.05). @entity28 and @entity28 @entity1 had comparable 30-day mortality (1.6% vs. 2.6%, P = 1.000), 90-day mortality (3.3% vs. 4.3%, P = 1.000), and incidence of @entity260 (19.7% vs. 18.3%, P = 0.819). Overall survival at 1, 3, and 5 years was similar for @entity28 @entity1 (83.6%, 63.6%, 41.6%) as for @entity28 @entity1 (80.9%, 65.9%, 49.1%; P = 0.358). Disease-free survival at 1, 3, and 5 years was also similar for @entity28 @entity1 (71.5%, 36.3%, 24.3%) as for @entity28 ones (60.2%, 43.7%, 27.7%; P = 0.969). CONCLUSION: Our propensity score-matched analysis strengthens the case that @entity28 does not adversely affect surgical outcomes of @entity157 @entity1 undergoing curative hepatectomy.

title: Obesity Does Not Influence Outcomes in XXXX @entity1 following Curative Hepatectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'Patients', 'patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['Obese', 'non-obese', 'obese', 'obesity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['solitary tumors']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']