abstract: BACKGROUND: @entity4006 is an a4b2 partial nicotinic agonist approved for smoking cessation. There have been spontaneous postmarketing reports of neuropsychiatric adverse events (NPAEs) in smokers without a history of @entity146 quitting with @entity4006 . METHODS: One hundred ten smokers without history of @entity146 (screened by Structured Clinical Interview for DSM-IV) were randomized to 12 weeks of @entity4006 1 mg twice daily (n = 55) or placebo. Adverse events were solicited systematically. @entity308 , @entity148 , @entity146 , and @entity146 were measured at baseline and weekly using the Montgomery-  sberg Depression Rating Scale (MADRS), the Hamilton Anxiety Scale (HAM-A), and the Overt Aggression Scale-Modified ( @entity35166 -M). The Profile of Mood States (POMS) was administered daily. Mixed-model analysis of repeated measures was conducted to compare mean changes in scores between groups across study periods. RESULTS: @entity1 ' mean baseline characteristics were 33 years of age, 22 cigarettes/day and Fagerstr  m Test for @entity1239 @entity734 score > 7. Reported NPAEs were similar between groups. No suicidal events were reported. There were no significant differences between groups for the MADRS ( @entity34 vs. placebo = .03, 95% confidence interval [CI] -.68-.73; NS), HAM-A ( @entity34 [ @entity34 ] = .14, 95% CI -.62-.90; NS), @entity35166 -M Aggression subscale ( @entity34 = .5, 95% CI -1.18-2.18; NS), @entity35166 -M Irritability subscale ( @entity34 = .08, 95% CI -.17-.34; NS), and the POMS total scores ( @entity34 = .5, 95% CI -.52-1.53; NS). CONCLUSIONS: There were no significant differences between groups on measures of @entity308 , @entity148 , or @entity146 /hostility. Systematically solicited NPAEs were similar between the @entity4006 and placebo groups.

title: A double-blind randomized placebo-controlled pilot study of neuropsychiatric adverse events in abstinent smokers treated with XXXX or placebo.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'Depressive symptoms']

entities_list: @entity4006 :: ('MESH:C500838', 'Chemical') :: ['varenicline', 'Varenicline']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression', 'psychiatric illness', 'irritability']

entities_list: @entity1239 :: ('MESH:D009538', 'Chemical') :: ['Nicotine']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['Dependence']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['TD', 'treatment difference']

answer: @entity4006 :: (MESH:C500838,Chemical) :: ['varenicline']


abstract: OBJECTIVE: To investigate acute @entity32 in the peritoneal cavity in adhesion formation. DESIGN: Prospective randomized, controlled trial. SETTING: University laboratory research center. ANIMAL(S): 9- to 10-week-old BALB/c female @entity19 . INTERVENTION(S): In a laparoscopic @entity19 model, acute @entity32 in the peritoneal cavity evaluated in @entity515 @entity516 enhanced @entity1104 , by @entity515 @entity516 plus manipulation, and in the latter group plus @entity619 . MAIN OUTCOME MEASURE(S): Qualitative and quantitative adhesion scores and an acute @entity32 score (neoangiogenesis, diapedesis, and leukocyte accumulation). RESULT(S): Adhesions at the lesion site were enhanced by the @entity515 @entity516 , further enhanced by manipulation, and decreased by the administration of @entity619 . The acute @entity32 scores (total, neoangiogenesis, diapedesis, and leukocyte accumulation) strongly correlated with the total adhesion score. @entity32 scores were similar at both the surgical lesion and the parietal peritoneum. CONCLUSION(S): Acute @entity32 of the entire peritoneum cavity is an important mechanism involved in adhesion formation and enhances adhesion formation at the lesion site.

title: Postoperative inflammation in the abdominal cavity increases adhesion formation in a laparoscopic XXXX model.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation']

entities_list: @entity516 :: ('MESH:D011027', 'Disease') :: ['pneumoperitoneum']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity1104 :: ('MESH:D000267', 'Disease') :: ['adhesions']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: @entity120 is a rare but well-established complication of @entity101 with a prevalence of 0.73% in one large autopsy series. In this report, we review the findings on chest radiographs in eight @entity1 with this complication. Portal @entity101 in these @entity1 was evidenced by the presence of @entity2312 . The causes of @entity101 were @entity1575 in seven @entity1 and portal @entity49 in one @entity1 . @entity120 was established by right heart catheterization and pressure measurement. Qualitative assessment of the radiographs showed that four @entity1 had the classic findings of @entity120 including prominent central pulmonary arteries and @entity4266 , three had @entity854 , and one had only @entity1283 . Measurements of the width of the right descending pulmonary artery and the pulmonary lobar diameter/transverse thoracic diameter ratio were made in five of the @entity1 in whom postero-anterior radiographs were available. The results confirmed our qualitative analysis, although they did not establish the diagnosis in borderline cases. We also observed that pulmonary vascular redistribution to the upper lobes was present in four @entity1 , a finding that has been reported in @entity1 with other causes of @entity120 . We conclude that the possibility of @entity120 should be raised in @entity1 with @entity101 , even when only subtle chest radiographic findings are present to suggest that diagnosis.

title: XXXX complicating @entity101 : findings on chest radiographs.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'portal hypertension']

entities_list: @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiomegaly']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'Pulmonary hypertension']

entities_list: @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['subtle abnormalities']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

entities_list: @entity2312 :: ('MESH:D004932', 'Disease') :: ['esophageal varices and/or ascites']

entities_list: @entity4266 :: ('MESH:D018497', 'Disease') :: ['right ventricular enlargement']

answer: @entity120 :: (MESH:D006976,Disease) :: ['Pulmonary hypertension']


abstract: @entity120 is a rare but well-established complication of @entity101 with a prevalence of 0.73% in one large autopsy series. In this report, we review the findings on chest radiographs in eight @entity1 with this complication. Portal @entity101 in these @entity1 was evidenced by the presence of @entity2312 . The causes of @entity101 were @entity1575 in seven @entity1 and portal @entity49 in one @entity1 . @entity120 was established by right heart catheterization and pressure measurement. Qualitative assessment of the radiographs showed that four @entity1 had the classic findings of @entity120 including prominent central pulmonary arteries and @entity4266 , three had @entity854 , and one had only @entity1283 . Measurements of the width of the right descending pulmonary artery and the pulmonary lobar diameter/transverse thoracic diameter ratio were made in five of the @entity1 in whom postero-anterior radiographs were available. The results confirmed our qualitative analysis, although they did not establish the diagnosis in borderline cases. We also observed that pulmonary vascular redistribution to the upper lobes was present in four @entity1 , a finding that has been reported in @entity1 with other causes of @entity120 . We conclude that the possibility of @entity120 should be raised in @entity1 with @entity101 , even when only subtle chest radiographic findings are present to suggest that diagnosis.

title: @entity120 complicating XXXX : findings on chest radiographs.

answer: @entity101 :: (MESH:D006973,Disease) :: ['portal hypertension']


abstract: BACKGROUND: @entity497 ( @entity497 ) is the leading cause of death in @entity1 worldwide and a substantial proportion of childhood @entity497 is caused by viruses. A better understanding of the role of @entity778 in this condition is needed to improve clinical management and preventive measures. The aim of the study was therefore to assess the association between specific @entity10201 viruses and childhood @entity497 . METHODS: A case-control study was conducted during 3   years in Stockholm, Sweden. Cases were @entity1 aged  <=5   years with radiological @entity497 . Healthy controls were consecutively enrolled at @entity1 health units during routine visits and matched to cases on age and calendar time. Nasopharyngeal aspirates were obtained and analysed by real-time PCR for 15 viruses. Multivariate conditional logistic regression was used to account for @entity325 with other viruses and baseline characteristics. RESULTS: A total of 121 cases, of which 93 cases met the WHO criteria for radiological @entity55 , and 240 controls were included in the study. Viruses were detected in 81% of the cases (n=98) and 56% of the controls (n=134). Influenza virus, metapneumovirus and @entity10201 were detected in 60% of cases and were significantly associated with @entity497 with ORs >10. There was no association with @entity15609 virus, @entity1 @entity9488 and coronavirus and bocavirus were negatively associated with @entity497 . CONCLUSIONS: Our study indicates viral @entity497 is an underestimated disease and points out @entity14536 as a new important target for the prevention of childhood @entity497 .

title: XXXX viruses associated with community-acquired @entity55 in @entity1 : matched case-control study.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human', 'child']

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['virus infections']

entities_list: @entity10201 :: ('12814', 'Species') :: ['respiratory', 'respiratory syncytial virus']

entities_list: @entity9488 :: ('MESH:D004769', 'Disease') :: ['enterovirus or rhinovirus']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity15609 :: ('MESH:D018184', 'Disease') :: ['parainfluenza']

entities_list: @entity497 :: ('MESH:D003147', 'Disease') :: ['Community-acquired pneumonia', 'CAP']

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['coinfections']

answer: @entity10201 :: (12814,Species) :: ['Respiratory']


abstract: BACKGROUND: @entity497 ( @entity497 ) is the leading cause of death in @entity1 worldwide and a substantial proportion of childhood @entity497 is caused by viruses. A better understanding of the role of @entity778 in this condition is needed to improve clinical management and preventive measures. The aim of the study was therefore to assess the association between specific @entity10201 viruses and childhood @entity497 . METHODS: A case-control study was conducted during 3   years in Stockholm, Sweden. Cases were @entity1 aged  <=5   years with radiological @entity497 . Healthy controls were consecutively enrolled at @entity1 health units during routine visits and matched to cases on age and calendar time. Nasopharyngeal aspirates were obtained and analysed by real-time PCR for 15 viruses. Multivariate conditional logistic regression was used to account for @entity325 with other viruses and baseline characteristics. RESULTS: A total of 121 cases, of which 93 cases met the WHO criteria for radiological @entity55 , and 240 controls were included in the study. Viruses were detected in 81% of the cases (n=98) and 56% of the controls (n=134). Influenza virus, metapneumovirus and @entity10201 were detected in 60% of cases and were significantly associated with @entity497 with ORs >10. There was no association with @entity15609 virus, @entity1 @entity9488 and coronavirus and bocavirus were negatively associated with @entity497 . CONCLUSIONS: Our study indicates viral @entity497 is an underestimated disease and points out @entity14536 as a new important target for the prevention of childhood @entity497 .

title: @entity10201 viruses associated with community-acquired XXXX in @entity1 : matched case-control study.

answer: @entity55 :: (MESH:D011014,Disease) :: ['pneumonia']


abstract: BACKGROUND: @entity497 ( @entity497 ) is the leading cause of death in @entity1 worldwide and a substantial proportion of childhood @entity497 is caused by viruses. A better understanding of the role of @entity778 in this condition is needed to improve clinical management and preventive measures. The aim of the study was therefore to assess the association between specific @entity10201 viruses and childhood @entity497 . METHODS: A case-control study was conducted during 3   years in Stockholm, Sweden. Cases were @entity1 aged  <=5   years with radiological @entity497 . Healthy controls were consecutively enrolled at @entity1 health units during routine visits and matched to cases on age and calendar time. Nasopharyngeal aspirates were obtained and analysed by real-time PCR for 15 viruses. Multivariate conditional logistic regression was used to account for @entity325 with other viruses and baseline characteristics. RESULTS: A total of 121 cases, of which 93 cases met the WHO criteria for radiological @entity55 , and 240 controls were included in the study. Viruses were detected in 81% of the cases (n=98) and 56% of the controls (n=134). Influenza virus, metapneumovirus and @entity10201 were detected in 60% of cases and were significantly associated with @entity497 with ORs >10. There was no association with @entity15609 virus, @entity1 @entity9488 and coronavirus and bocavirus were negatively associated with @entity497 . CONCLUSIONS: Our study indicates viral @entity497 is an underestimated disease and points out @entity14536 as a new important target for the prevention of childhood @entity497 .

title: @entity10201 viruses associated with community-acquired @entity55 in XXXX : matched case-control study.

answer: @entity1 :: (9606,Species) :: ['children']


abstract: PURPOSE: @entity177 ( @entity177 ) is frequent in @entity1 eligible for cardiac resynchronization therapy (CRT) and may be worsened by the use of contrast agents. We sought to determine the feasibility of CRT implantation without contrast injection in @entity1 with contraindication to @entity1496 . METHODS: @entity1 eligible for CRT and presenting with @entity177 were prospectively included (non-contrast NC group). A contemporary control group (CG) of CRT @entity1 with contrast injection was used for comparison. An over-the-wire coronary sinus (CS) lead with an angled distal tip was selected for this "blind harpooning" technique. RESULTS: Seventeen @entity1 in the NC group were included (78        7  years). Serum @entity1011 was 208        86   mol/L (glomerular filtration rate 33        15  mL/ @entity1009 .73  m(2)). CG included 25 @entity1 (70        7  years, serum @entity1011 85        21   mol/L). CRT implantation was successful in 16/17 @entity1 (94.1  %) without contrast injection. The mean procedure and fluoroscopy times were similar in the two groups: 146        29 in the NC group versus 153        25  min (p   =   0.57) and 25        12 in the NC group versus 23        16  min (p   =   0.7) respectively. The mean CS lead implantation time was 36        19 (NC group) versus 39        15  min (p   =   0.64). No major procedure-related complications were observed in both groups. CONCLUSION: CRT implantation is feasible in the majority of the cases (94.1  %) without contrast injection and without lengthening the procedure time in @entity1 with @entity177 .

title: Non-contrast cardiac resynchronization therapy implantation is feasible in case of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['Renal insufficiency', 'RI']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity177 :: (MESH:D051437,Disease) :: ['renal insufficiency']


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity1 with @entity164 2 @entity6 are not well-understood. The study objective was to evaluate effects of conjugated @entity4722 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity32 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity4722 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity28 @entity1 with @entity164 2 @entity6 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity1851 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity165 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity4722 in serum of @entity1 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity32 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity6 treatments to improve risk factors for @entity2412 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity32 and blood lipids in @entity28 , post-menopausal @entity1 with XXXX 2 @entity6 : a randomized, double-masked, crossover study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'people']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity2412 :: ('MESH:D048909', 'Disease') :: ['diabetes-related complications']

entities_list: @entity4722 :: ('MESH:D019787', 'Chemical') :: ['linoleic acid']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity1 with @entity164 2 @entity6 are not well-understood. The study objective was to evaluate effects of conjugated @entity4722 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity32 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity4722 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity28 @entity1 with @entity164 2 @entity6 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity1851 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity165 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity4722 in serum of @entity1 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity32 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity6 treatments to improve risk factors for @entity2412 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity32 and blood lipids in XXXX , post-menopausal @entity1 with @entity164 2 @entity6 : a randomized, double-masked, crossover study.

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity1 with @entity164 2 @entity6 are not well-understood. The study objective was to evaluate effects of conjugated @entity4722 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity32 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity4722 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity28 @entity1 with @entity164 2 @entity6 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity1851 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity165 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity4722 in serum of @entity1 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity32 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity6 treatments to improve risk factors for @entity2412 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity32 and blood lipids in @entity28 , post-menopausal @entity1 with @entity164 2 XXXX : a randomized, double-masked, crossover study.

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity1 with @entity164 2 @entity6 are not well-understood. The study objective was to evaluate effects of conjugated @entity4722 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity32 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity4722 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity28 @entity1 with @entity164 2 @entity6 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity1851 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity165 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity4722 in serum of @entity1 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity32 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity6 treatments to improve risk factors for @entity2412 .

title: Time-dependent effects of safflower oil to improve glycemia, XXXX and blood lipids in @entity28 , post-menopausal @entity1 with @entity164 2 @entity6 : a randomized, double-masked, crossover study.

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: BACKGROUND _ AIMS: Metabolic effects of dietary fat quality in @entity1 with @entity164 2 @entity6 are not well-understood. The study objective was to evaluate effects of conjugated @entity4722 (CLA) and safflower (SAF) oils on glycemia, blood lipids, and @entity32 . The hypothesis we tested is that dietary oils improve glycemia, lipids, and inflammatory markers in a time-dependent way that follows accumulation of @entity4722 and CLA isomers in serum of subjects supplemented with dietary oils. METHODS: Fifty-five post-menopausal, @entity28 @entity1 with @entity164 2 @entity6 enrolled, and 35 completed this randomized, double-masked crossover study. Treatments were 8  g daily of CLA and SAF for 16 weeks each. We used a multiple testing procedure with pre-determined steps analysis to determine the earliest time that a significant effect was detected. RESULTS: CLA did not alter measured metabolic parameters. SAF decreased HbA1c (-0.64      0.18%, p  =  0.0007) and @entity1851 (-13.6      8.2  mg/L, p  =  0.0472), increased QUICKI (0.0077      0.0035, p  =  0.0146) with a minimum time to effect observed 16 weeks after treatment. SAF increased HDL @entity165 (0.12      0.05  mmol/L, p  =  0.0228) with the minimum time to detect an effect of SAF at 12 weeks. The minimum time to detect an increase of c9t11-CLA, t10c12-CLA, and @entity4722 in serum of @entity1 supplemented CLA or SAF, respectively, was four weeks. CONCLUSIONS: We conclude that 8  g of SAF daily improved glycemia, @entity32 , and blood lipids, indicating that small changes in dietary fat quality may augment @entity6 treatments to improve risk factors for @entity2412 .

title: Time-dependent effects of safflower oil to improve glycemia, @entity32 and blood lipids in @entity28 , post-menopausal XXXX with @entity164 2 @entity6 : a randomized, double-masked, crossover study.

answer: @entity1 :: (9606,Species) :: ['women']


abstract: UNASSIGNED: @entity2679 and perforation are severe complications of @entity14784 , which have a challenging preoperative diagnosis. Early identification allows better surgical management. Contrast-enhanced computed tomography (ceCT) is the current diagnostic gold standard. Contrast-enhanced ultrasonography (CEUS) is a promising tool for the diagnosis of @entity1085 , but data from the literature concerning efficacy are sparse. The aim of the study was to evaluate CEUS findings in pathologically proven complicated @entity2679 ( @entity13879 , @entity1085 , @entity733 ). A total of 8 @entity1 submitted to preoperative CEUS, and with subsequent proven acute complicated @entity2679 at surgical inspection and pathological analysis, were retrospectively identified. The final diagnosis was @entity13879 /phlegmonous @entity2679 (n. 2), phlegmonous/ulcerative changes plus @entity733 (n. 2), perforated plus @entity733 (n. 3), or perforated plus pericholecystic biliary collection (n. 1). Conventional US findings revealed irregularly thickened gallbladder walls in all 8 @entity1 , with vaguely defined walls in 7 @entity1 , four of whom also had striated wall thickening. CEUS revealed irregular enhancing gallbladder walls in all @entity1 . A distinct wall defect was seen in six @entity1 , confirmed as @entity13879 /phlegmonous @entity2679 at pathology in all six, and in four as perforation at macroscopic surgical inspection. CEUS is a non-invasive easily repeatable technique that can be performed at the bedside, and is able to accurately diagnose complicated/perforated @entity2679 . Despite the limited sample size in the present case series, CEUS appears as a promising tool for the management of @entity1 with the clinical possibility of having an acute complicated @entity2679 .

title: Contrast-enhanced ultrasonography to diagnose complicated XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1085 :: ('MESH:D005705', 'Disease') :: ['gallbladder perforation', 'perforated gallbladder']

entities_list: @entity13879 :: ('MESH:D005734', 'Disease') :: ['gangrenous']

entities_list: @entity733 :: ('MESH:D000038', 'Disease') :: ['pericholecystic abscess']

entities_list: @entity2679 :: ('MESH:D002764', 'Disease') :: ['cholecystitis', 'Gangrenous cholecystitis']

entities_list: @entity14784 :: ('MESH:D041881', 'Disease') :: ['acute cholecystitis']

answer: @entity14784 :: (MESH:D041881,Disease) :: ['acute cholecystitis']


abstract: STUDY DESIGN: Mixed retrospective-prospective cohort study. OBJECTIVES: To determine 2-year survival following discharge from hospital after @entity1566 in Bangladesh. SETTING: Bangladesh. METHODS: Medical records were used to identify all @entity1 admitted in 2011 with a recent @entity1566 to the Centre for Rehabilitation of the Paralysed, a large Bangladeshi hospital that specialises in care of @entity1 with @entity1566 . @entity1 or their families were subsequently visited or contacted by telephone in 2014. Vital status and, where relevant, date and cause of @entity204 were determined by verbal autopsy. RESULTS: 350 of 371 @entity1 admitted with a recent @entity1566 in 2011 were discharged alive from hospital. All but eleven were accounted for two years after discharge (97% follow-up). Two-year survival was 87% (95% CI 83% to 90%). Two-year survival of those who were wheelchair-dependent was 81% (95% CI 76% to 86%). The most common cause of @entity204 was @entity295 due to pressure @entity1066 . CONCLUSION: In Bangladesh, approximately one in five @entity1 with @entity1566 who are wheelchair-dependent die within two years of discharge from hospital. Most @entity204 are due to @entity295 from potentially preventable pressure @entity1066 .Spinal Cord advance online publication, 16 June 2015; doi:10.1038/sc.2015.92.

title: Two-year survival following discharge from hospital after XXXX in Bangladesh.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'people']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: In @entity1860 ( @entity1860 ) and @entity981 ( @entity981 ) the @entity12297 chromosome (22q-) is the most frequent @entity2008 encountered. At the molecular level the @entity1861 gene from chr. 9 is translocated to the bcr gene on chr. 22. As a result, a chimeric @entity1861 gene is generated, which encodes chimeric proteins. Since these proteins are only expressed in @entity12297 positive cells, they are per definition @entity5 -specific. In this report we describe the reactivity of polyvalent antisera raised against synthetic peptides corresponding to the @entity5 -specific @entity1861 junctions. Native chimeric proteins were specifically recognized by these junction-specific antisera. Therefore we conclude that the @entity1861 junctions are antigenically exposed on the chimeric proteins. We discuss the relevance of these antisera for @entity1860 and @entity981 diagnosis.

title: Detection of @entity5 -specific antigens in XXXX .

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal aberration']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['ALL', 'acute lymphoblastic leukemia']

entities_list: @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML', 'chronic myeloid leukemia']

answer: @entity1860 :: (MESH:D015464,Disease) :: ['Philadelphia chromosome positive leukemias']


abstract: In @entity1860 ( @entity1860 ) and @entity981 ( @entity981 ) the @entity12297 chromosome (22q-) is the most frequent @entity2008 encountered. At the molecular level the @entity1861 gene from chr. 9 is translocated to the bcr gene on chr. 22. As a result, a chimeric @entity1861 gene is generated, which encodes chimeric proteins. Since these proteins are only expressed in @entity12297 positive cells, they are per definition @entity5 -specific. In this report we describe the reactivity of polyvalent antisera raised against synthetic peptides corresponding to the @entity5 -specific @entity1861 junctions. Native chimeric proteins were specifically recognized by these junction-specific antisera. Therefore we conclude that the @entity1861 junctions are antigenically exposed on the chimeric proteins. We discuss the relevance of these antisera for @entity1860 and @entity981 diagnosis.

title: Detection of XXXX -specific antigens in @entity1860 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: An algorithm is proposed for the conversion of a virtual-bond polypeptide chain (connected C alpha atoms) to an all-atom backbone, based on determining the most extensive @entity3884 -bond network between the peptide groups of the backbone, while maintaining all of the backbone atoms in energetically feasible conformations. @entity3884 bonding is represented by aligning the peptide-group dipoles. These peptide groups are not contiguous in the @entity535 sequence. The first dipoles to be aligned are those that are both sufficiently close in space to be arranged in approximately linear arrays termed dipole paths. The criteria used in the construction of dipole paths are: to assure good alignment of the greatest possible number of dipoles that are close in space; to optimize the electrostatic interactions between the dipoles that belong to different paths close in space; and to avoid locally unfavorable @entity535 residue conformations. The equations for dipole alignment are solved separately for each path, and then the remaining single dipoles are aligned optimally with the electrostatic field from the dipoles that belong to the dipole-path network. A least-squares minimizer is used to keep the geometry of the alpha- @entity505 trace of the resulting backbone close to that of the input virtual-bond chain. This procedure is sufficient to convert the virtual-bond chain to a real chain; in applications to real systems, however, the final structure is obtained by minimizing the total ECEPP/2 (empirical conformational energy program for peptides) energy of the system, starting from the geometry resulting from the solution of the alignment equations. When applied to model alpha-helical and beta-sheet structures, the algorithm, followed by the ECEPP/2 energy minimization, resulted in an energy and backbone geometry characteristic of these alpha-helical and beta-sheet structures. Application to the alpha- @entity505 trace of the backbone of the crystallographic 5PTI structure of @entity291 pancreatic trypsin inhibitor, followed by ECEPP/2 energy minimization with C alpha-distance constraints, led to a structure with almost as low energy and root mean square deviation as the ECEPP/2 geometry analog of 5PTI, the best agreement between the crystal and reconstructed backbone being observed for the residues involved in the dipole-path network.

title: Calculation of protein backbone geometry from alpha- XXXX coordinates based on peptide-group dipole alignment.

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity3884 :: ('MESH:D006859', 'Chemical') :: ['hydrogen', 'Hydrogen']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['carbon']


abstract: OBJECTIVE: The aim was to study whether basal or cytokine stimulated generation of @entity842 (NO) modulates platelet adhesion to @entity1 umbilical vein endothelial cells (HUVEC). METHODS: The adhesion of 111In labelled @entity1 platelets to transfected HUVEC (SGHEC-7) was measured either alone or after incubation of SGHEC-7 cells for 18 h with @entity1356 ( @entity1356 ) and/or @entity5 necrosis factor alpha ( @entity310 ). The activity of NO synthase in these cells was measured by formation of @entity7792 . The effects of @entity619 (0.3 microM) and @entity7293 ( @entity7293 , 100 microM) on these two variables were determined. RESULTS: Stimulation of SGHEC-7 cells with @entity1356 or @entity310 (each at 1-30 ng.ml-1) caused them to express the @entity3623 , an effect that was prevented by @entity619 . Platelet adhesion to unstimulated SGHEC-7 cells was < 0.1% (n = 3) and was increased to 0.7 (SEM 0.2)% by @entity7293 but was not affected by @entity619 . Stimulation of the cells with @entity1356 and @entity310 @entity1423 to a maximum of 2.2(0.4)%. This increase was enhanced by both @entity619 and @entity7293 . The effect of @entity7293 was prevented by @entity534 . CONCLUSIONS: Inhibition of NO synthesis by @entity7293 potentiates platelet adhesion to unstimulated SGHEC-7 cells, showing that basally released NO regulates platelet adhesion. Stimulation of SGHEC-7 cells by cytokines increases their adhesive properties but at the same time causes them to express the @entity3623 . @entity842 generated by this enzyme contributes to the modulation of the adhesive properties of the endothelial cells. Thus both constitutive and inducible NO synthases modulate endothelial cell thrombogenicity.

title: Platelet adhesion to @entity1 vascular endothelium is modulated by constitutive and cytokine induced XXXX .

entities_list: @entity7792 :: ('CHEBI:16349', 'Chemical') :: ['citrulline']

entities_list: @entity1356 :: ('3553', 'Gene') :: ['interleukin-1 beta', 'IL-1 beta']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['increased platelet adhesion']

entities_list: @entity534 :: ('CHEBI:16467', 'Chemical') :: ['L-arginine']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity7293 :: ('CHEBI:28229', 'Chemical') :: ['L-NMMA', 'NG-monomethyl-L-arginine']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide', 'nitric oxide']

entities_list: @entity3623 :: ('4843', 'Gene') :: ['inducible NO synthase']

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: OBJECTIVE: The aim was to study whether basal or cytokine stimulated generation of @entity842 (NO) modulates platelet adhesion to @entity1 umbilical vein endothelial cells (HUVEC). METHODS: The adhesion of 111In labelled @entity1 platelets to transfected HUVEC (SGHEC-7) was measured either alone or after incubation of SGHEC-7 cells for 18 h with @entity1356 ( @entity1356 ) and/or @entity5 necrosis factor alpha ( @entity310 ). The activity of NO synthase in these cells was measured by formation of @entity7792 . The effects of @entity619 (0.3 microM) and @entity7293 ( @entity7293 , 100 microM) on these two variables were determined. RESULTS: Stimulation of SGHEC-7 cells with @entity1356 or @entity310 (each at 1-30 ng.ml-1) caused them to express the @entity3623 , an effect that was prevented by @entity619 . Platelet adhesion to unstimulated SGHEC-7 cells was < 0.1% (n = 3) and was increased to 0.7 (SEM 0.2)% by @entity7293 but was not affected by @entity619 . Stimulation of the cells with @entity1356 and @entity310 @entity1423 to a maximum of 2.2(0.4)%. This increase was enhanced by both @entity619 and @entity7293 . The effect of @entity7293 was prevented by @entity534 . CONCLUSIONS: Inhibition of NO synthesis by @entity7293 potentiates platelet adhesion to unstimulated SGHEC-7 cells, showing that basally released NO regulates platelet adhesion. Stimulation of SGHEC-7 cells by cytokines increases their adhesive properties but at the same time causes them to express the @entity3623 . @entity842 generated by this enzyme contributes to the modulation of the adhesive properties of the endothelial cells. Thus both constitutive and inducible NO synthases modulate endothelial cell thrombogenicity.

title: Platelet adhesion to XXXX vascular endothelium is modulated by constitutive and cytokine induced @entity842 .

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The Augsburg @entity583 Register recorded in 1985, 999 coronary events (734 @entity1 , 265 @entity1 ) occurring in 25-74-year-old residents of the city of Augsburg and the counties of Augsburg and Aichach-Friedberg (study population: 156,489 @entity1 and 171,093 @entity1 ). On average, 444 @entity1 and 138 @entity1 per 100,000 of the population suffered an @entity583 ( @entity583 ) in 1985. The risk of morbidity increased with age in both @entity1 and @entity1 , but gained significance for @entity1 only after their 55th year of life. The 28-day case fatality was 54% for male @entity583 cases and 66% for females; 34% of the @entity583 @entity1 died without ever reaching a hospital. Cardiopulmonary resuscitation (CPR) was attempted by a physician in one-in-three of these out-of-hospital deaths. Although one of two out-of-hospital deaths occurred in the presence of a medical lay @entity1 ; lay CPR was the exception. Broader population education in CPR techniques may thus constitute one method of reducing the number of early @entity583 . The median prehospital time for interviewed hospital @entity1 (66%) was 5 h, and approximately 2 h for @entity1 with systemic thrombolysis (n = 71). The combination of fatal coronary events from the official cause-of-death statistics and the results from the Augsburg register were used to estimate @entity583 morbidity for the whole of the FRG in 1985. This leads to an expected morbidity of 210,000 @entity583 , of which 141,000 @entity583 will be fatal (both sexes).

title: [The XXXX status of a South German population: results of the Augsburg @entity583 register l985].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'person', 'men']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'Myocardial Infarction', 'acute myocardial infarction', 'AMI deaths']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarct']


abstract: The Augsburg @entity583 Register recorded in 1985, 999 coronary events (734 @entity1 , 265 @entity1 ) occurring in 25-74-year-old residents of the city of Augsburg and the counties of Augsburg and Aichach-Friedberg (study population: 156,489 @entity1 and 171,093 @entity1 ). On average, 444 @entity1 and 138 @entity1 per 100,000 of the population suffered an @entity583 ( @entity583 ) in 1985. The risk of morbidity increased with age in both @entity1 and @entity1 , but gained significance for @entity1 only after their 55th year of life. The 28-day case fatality was 54% for male @entity583 cases and 66% for females; 34% of the @entity583 @entity1 died without ever reaching a hospital. Cardiopulmonary resuscitation (CPR) was attempted by a physician in one-in-three of these out-of-hospital deaths. Although one of two out-of-hospital deaths occurred in the presence of a medical lay @entity1 ; lay CPR was the exception. Broader population education in CPR techniques may thus constitute one method of reducing the number of early @entity583 . The median prehospital time for interviewed hospital @entity1 (66%) was 5 h, and approximately 2 h for @entity1 with systemic thrombolysis (n = 71). The combination of fatal coronary events from the official cause-of-death statistics and the results from the Augsburg register were used to estimate @entity583 morbidity for the whole of the FRG in 1985. This leads to an expected morbidity of 210,000 @entity583 , of which 141,000 @entity583 will be fatal (both sexes).

title: [The @entity583 status of a South German population: results of the Augsburg XXXX register l985].

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarct']


abstract: OBJECTIVE: Our goal was to evaluate whether treatment of @entity6981 during pregnancy with 2% @entity3402 vaginal cream reduces the incidence of either @entity3152 or low birth weight or of both. STUDY DESIGN: A multicenter, double-blind, randomized, placebo-controlled trial in Indonesia compared a 2% @entity3402 vaginal cream with a placebo cream. @entity1 seeking prenatal care at 14 to 26 weeks of gestational age who had @entity6981 (Gram stain score > 6 and pH of vaginal fluid > 4.5) were invited to participate. Of the 745 @entity1 enrolled, 681 (91.4%) @entity1 were followed up through delivery. RESULTS: @entity3402 vaginal cream was an effective treatment for @entity6981 . Two weeks after completion of the treatment, 85.5% of the @entity1 were cured. The rate of @entity3152 (< 37 weeks) was 15.0% for @entity3402 @entity1 and 13.5% for placebo @entity1 (odds ratio 1.1, 95% confidence interval 0.7 to 1.7). The rate of low birth weight was 9.0% for @entity3402 @entity1 and 6.8% for placebo @entity1 (odds ratio 1.3, 95% confidence interval 0.8 to 2.4). CONCLUSIONS: Treatment of @entity6981 with @entity3402 vaginal cream did not reduce @entity3152 or low birth weight. Although @entity3402 vaginal cream is an effective treatment for @entity6981 , intravaginal treatment would not be effective against @entity6981 harbored in the upper genital tract. Systemic treatment may be required to eradicate upper tract infection to reduce @entity3152 .

title: Intravaginal @entity3402 treatment for @entity6981 : effects on XXXX and low birth weight.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women']

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery']

entities_list: @entity6981 :: ('MESH:D016585', 'Disease') :: ['bacterial vaginosis-associated microorganisms', 'bacterial vaginosis']

entities_list: @entity3402 :: ('MESH:D002981', 'Chemical') :: ['clindamycin', 'Clindamycin']

answer: @entity3152 :: (MESH:D007752,Disease) :: ['preterm delivery']


abstract: OBJECTIVE: Our goal was to evaluate whether treatment of @entity6981 during pregnancy with 2% @entity3402 vaginal cream reduces the incidence of either @entity3152 or low birth weight or of both. STUDY DESIGN: A multicenter, double-blind, randomized, placebo-controlled trial in Indonesia compared a 2% @entity3402 vaginal cream with a placebo cream. @entity1 seeking prenatal care at 14 to 26 weeks of gestational age who had @entity6981 (Gram stain score > 6 and pH of vaginal fluid > 4.5) were invited to participate. Of the 745 @entity1 enrolled, 681 (91.4%) @entity1 were followed up through delivery. RESULTS: @entity3402 vaginal cream was an effective treatment for @entity6981 . Two weeks after completion of the treatment, 85.5% of the @entity1 were cured. The rate of @entity3152 (< 37 weeks) was 15.0% for @entity3402 @entity1 and 13.5% for placebo @entity1 (odds ratio 1.1, 95% confidence interval 0.7 to 1.7). The rate of low birth weight was 9.0% for @entity3402 @entity1 and 6.8% for placebo @entity1 (odds ratio 1.3, 95% confidence interval 0.8 to 2.4). CONCLUSIONS: Treatment of @entity6981 with @entity3402 vaginal cream did not reduce @entity3152 or low birth weight. Although @entity3402 vaginal cream is an effective treatment for @entity6981 , intravaginal treatment would not be effective against @entity6981 harbored in the upper genital tract. Systemic treatment may be required to eradicate upper tract infection to reduce @entity3152 .

title: Intravaginal @entity3402 treatment for XXXX : effects on @entity3152 and low birth weight.

answer: @entity6981 :: (MESH:D016585,Disease) :: ['bacterial vaginosis']


abstract: OBJECTIVE: Our goal was to evaluate whether treatment of @entity6981 during pregnancy with 2% @entity3402 vaginal cream reduces the incidence of either @entity3152 or low birth weight or of both. STUDY DESIGN: A multicenter, double-blind, randomized, placebo-controlled trial in Indonesia compared a 2% @entity3402 vaginal cream with a placebo cream. @entity1 seeking prenatal care at 14 to 26 weeks of gestational age who had @entity6981 (Gram stain score > 6 and pH of vaginal fluid > 4.5) were invited to participate. Of the 745 @entity1 enrolled, 681 (91.4%) @entity1 were followed up through delivery. RESULTS: @entity3402 vaginal cream was an effective treatment for @entity6981 . Two weeks after completion of the treatment, 85.5% of the @entity1 were cured. The rate of @entity3152 (< 37 weeks) was 15.0% for @entity3402 @entity1 and 13.5% for placebo @entity1 (odds ratio 1.1, 95% confidence interval 0.7 to 1.7). The rate of low birth weight was 9.0% for @entity3402 @entity1 and 6.8% for placebo @entity1 (odds ratio 1.3, 95% confidence interval 0.8 to 2.4). CONCLUSIONS: Treatment of @entity6981 with @entity3402 vaginal cream did not reduce @entity3152 or low birth weight. Although @entity3402 vaginal cream is an effective treatment for @entity6981 , intravaginal treatment would not be effective against @entity6981 harbored in the upper genital tract. Systemic treatment may be required to eradicate upper tract infection to reduce @entity3152 .

title: Intravaginal XXXX treatment for @entity6981 : effects on @entity3152 and low birth weight.

answer: @entity3402 :: (MESH:D002981,Chemical) :: ['clindamycin']


abstract: AIM: To investigate spleen status in @entity1569 and its relationship with @entity1560 , Psoriasis Area and Severity Index, and insulin resistance. METHODS: Seventy-nine psoriatic @entity1 who were not suffering from any chronic @entity32 were retrospectively selected for inclusion in this study, and their complete medical records were accessed. An age- and sex-matched group of 80 non-psoriatic, @entity28 @entity1 was included as a control. The following relevant data were collected: age, sex, weight, height, body mass index, waist circumference, blood pressure, insulin resistance status, age at @entity1569 onset, and severity of @entity1569 . Abdominal ultrasonography was performed to determine spleen longitudinal diameter (SLD), and @entity1560 grade. RESULTS: The SLD of control @entity28 @entity1 was greater than that of psoriatic subjects (P = 0.013), but body mass index predicted the size of the spleen in psoriatic @entity1 (P < 0.001). The SLD of psoriatic @entity1 with normal weight was significantly reduced with respect to the overweight/ @entity28 psoriatic @entity1 (P = 0.002). A multiple regression analysis revealed that body mass index was a unique predictor of the spleen size (P < 0.001). Finally, the disease duration predicted the spleen size in psoriatic subjects (P = 0.038). CONCLUSION: This study shows a correlation between the SLD and the duration of @entity1569 .

title: Nonalcoholic fatty liver disease, spleen and XXXX : New aspects of low-grade chronic @entity32 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['hepatic steatosis']

answer: @entity1569 :: (MESH:D011565,Disease) :: ['psoriasis']


abstract: AIM: To investigate spleen status in @entity1569 and its relationship with @entity1560 , Psoriasis Area and Severity Index, and insulin resistance. METHODS: Seventy-nine psoriatic @entity1 who were not suffering from any chronic @entity32 were retrospectively selected for inclusion in this study, and their complete medical records were accessed. An age- and sex-matched group of 80 non-psoriatic, @entity28 @entity1 was included as a control. The following relevant data were collected: age, sex, weight, height, body mass index, waist circumference, blood pressure, insulin resistance status, age at @entity1569 onset, and severity of @entity1569 . Abdominal ultrasonography was performed to determine spleen longitudinal diameter (SLD), and @entity1560 grade. RESULTS: The SLD of control @entity28 @entity1 was greater than that of psoriatic subjects (P = 0.013), but body mass index predicted the size of the spleen in psoriatic @entity1 (P < 0.001). The SLD of psoriatic @entity1 with normal weight was significantly reduced with respect to the overweight/ @entity28 psoriatic @entity1 (P = 0.002). A multiple regression analysis revealed that body mass index was a unique predictor of the spleen size (P < 0.001). Finally, the disease duration predicted the spleen size in psoriatic subjects (P = 0.038). CONCLUSION: This study shows a correlation between the SLD and the duration of @entity1569 .

title: Nonalcoholic fatty liver disease, spleen and @entity1569 : New aspects of low-grade chronic XXXX .

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: AIM: To review and assess the evidence related to cetuximab treatment in metastatic @entity14 (mCRC) with regard to @entity984 status. METHODS: PubMed, EMBASE, Cochrane database and American Society of Clinical Oncology meeting abstracts were searched for randomized controlled trials (RCTs) reporting the effect of @entity984 status on efficacy of chemotherapy regimen with or without cetuximab in mCRC. Baseline information such as sex and age was summarized from the included studies. Hazard ratios of progression-free survival (PFS) and @entity1349 ( @entity1349 ) as well as objective response based on @entity984 status were extracted for analysis. RESULTS: A total of 8 RCTs with 6780 @entity1 were included. The combined analysis showed that cetuximab failed to improve the @entity1349 and PFS in @entity1 with mCRC. However, in subgroup analysis, the pooled data showed that addition of cetuximab to @entity2600 containing chemotherapy regimen was sufficient to improve @entity1349 and PFS in wild-type @entity984 mCRC @entity1 , but not in @entity1 with mutant-type @entity984 . The addition of cetuximab increased the incidence of adverse events such as @entity294 , @entity1910 , skin @entity137 / @entity1910 , and @entity390 and @entity391 . There was no significant publication bias existing in the included studies. CONCLUSION: The clinical benefit of cetuximab was only confirmed in @entity1 with wild-type @entity984 . @entity984 status could be considered a biomarker of efficacy of cetuximab.

title: Standard chemotherapy with cetuximab for treatment of XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2600 :: ('MESH:C051890', 'Chemical') :: ['irinotecan']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: @entity3017 is a rare @entity788 with a distinctive histologic appearance that generally affects @entity1 and young @entity1 . We have studied 14 cases of @entity3017 and reviewed 41 previously reported examples. Nine of our cases occurred in @entity1 (from newborn to 4 years old; mean, 2.4), and five affected adults (from 19 to 56 years old; mean, 40). There were 8 male cases and 6 female cases. Most @entity1 presented with incidental abdominal masses, although @entity158 , @entity353 , and @entity3883 were present, but rarely. The @entity5 were very cellular microscopically, with cytologically uniform epithelial cells arranged in sheets and nests. Well-formed acinar structures were a consistent feature, and several cases contained ectatic ductular formations, rarely exhibiting intracellular mucin. Consistently present were squamoid corpuscles: circumscribed, whorled nests of plump spindle cells with a squamous appearance and occasional keratinization. The stroma was moderate to abundant and frequently quite cellular (especially in the pediatric cases). By immunohistochemistry, the @entity5 exhibited acinar, endocrine, and ductal differentiation, with positivity for pancreatic enzymes (100%), endocrine markers (82%), and carcinoembryonic antigen (85%). Ultrastructural examination most commonly revealed acinar differentiation, although mucigen granules and neurosecretory granules were also occasionally found. The behavior was variable: 36% of @entity1 developed @entity3 , especially to the liver. The adult @entity1 did poorly: three of five died of @entity5 (mean survival, 18 months), and two were alive at 5 and 15 months, respectively. In contrast, five of the six evaluable pediatric @entity1 were alive from 22 months to 22 years after diagnosis, and only one died of @entity5 after 16 months. Good responses to chemotherapy were noted in the pediatric group.

title: XXXX . A clinicopathologic study and review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants']

entities_list: @entity3883 :: ('MESH:D041781', 'Disease') :: ['obstructive jaundice']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic tumor']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity3017 :: ('MESH:C537162', 'Disease') :: ['Pancreatoblastoma', 'pancreatoblastoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity3017 :: (MESH:C537162,Disease) :: ['Pancreatoblastoma']


abstract: (Full text is available at http://www.manu.edu.mk/prilozi). With the introduction of new techniques in diagnostic and interventional radiology and progress in micro neurosurgery, accurate knowledge of the brain blood vessels is essential for daily clinical work. The aim of this study was to describe the morphological characteristics of the @entity76 and to emphasize their clinical significance. In this study we examined radiographs of 109 @entity1 who had CT angiography at the University Clinic for Radiology in Skopje, R. Macedonia. This study included 49 females and 60 males, ranging in age from 27 to 83 years; mean age 57.4    11.8 years. In 105 @entity1 SCA arose from the basilar artery on both sides as a single vessel. In two @entity1 SCA arose as a duplicate trunk from the basilar artery. We found unilateral duplication on the right SCA in one @entity1 , and bilateral duplication in one @entity1 . In two @entity1 was noticed origin of the SCA from PCA as a single trunk from adult type of the PCA. Through knowledge of the anatomy and variations of SCA is important for clinicians as well as basic scientists who deal with problems related to intracranial vasculature in daily basis for save performance of diagnostic and interventional procedures. Key words: @entity76 , anatomy, variations, basilar artery.

title: Morphological characteristics of the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity76 :: ('MESH:D002526', 'Disease') :: ['superior cerebellar artery']

answer: @entity76 :: (MESH:D002526,Disease) :: ['superior cerebellar artery']


abstract: Although @entity4098 tattooing is now a well-accepted step in breast reconstruction, little is known about its long-term effectiveness. A retrospective study of our 6-year experience in tattooing 151 @entity1 was thus carried out. @entity1 were surveyed regarding color match, satisfaction, and complications. Follow-up ranged from 1 to 75 months (mean, 25.2 months). Fifty-seven percent of respondents said their tattoo looked similar to the normal areola. There were five (3%) @entity281 , one @entity1910 , and one slough. Ten percent of tattoos needed a touch-up later to correct for excessive fading. Nearly 60% of tattoos were ultimately lighter than the normal. Eighty-four percent of the tattoos were rated as satisfactory, and 86% of the @entity1 said they would repeat the procedure if given the same choice again. Nipple-areola tattooing done with @entity1933 and @entity6701 pigments thus appears to be a reasonably safe and effective procedure in most @entity1 but may require one or more subsequent touch-ups for appropriate color match.

title: Long-term experience with XXXX tattooing.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4098 :: ('MESH:D010144', 'Disease') :: ['nipple-areola']

entities_list: @entity1933 :: ('MESH:C000499', 'Chemical') :: ['iron oxide']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity6701 :: ('MESH:C009495', 'Chemical') :: ['titanium dioxide']

answer: @entity4098 :: (MESH:D010144,Disease) :: ['nipple-areola']


abstract: PURPOSE: Recently, a novel multi-model monitor has been available, which integrates real-time signals of transcranial Doppler (TCD) and video-EEG (vEEG) into one workstation. We sought to test the feasibility of this device in detecting @entity531 in @entity1 with @entity302 . METHOD: Cerebral blood flow velocity (CBFV) of bilateral middle cerebral arteries and vEEG during @entity410 episodes were recorded simultaneously in 12 @entity1 (age 17-58 years) with @entity302 . The correlations between vEEG and CBFV findings were analyzed. RESULTS: Eleven @entity410 episodes were detected in 5 @entity1 . Of them, bilateral CBFV increase with interhemispheric asymmetry was observed in 4 @entity410 episodes of 3 @entity1 . EEG abnormalities preceded CBFV increase by 1-3s at the onset of a @entity410 . In a @entity1 with bilateral @entity2500 , no apparent CBFV changes were detected during 2 of 3 @entity410 episodes. Another @entity1 with previous frontal @entity548 displayed CBFV increase without interhemispheric asymmetry during 4 @entity410 episodes. CONCLUSION: It is feasible to evaluate @entity531 with good temporal correlation in @entity1 with frequent @entity410 episodes by real-time TCD-vEEG monitoring.

title: Real-time TCD-vEEG monitoring for XXXX in @entity302 .

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery stenosis']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'partial epilepsies']

entities_list: @entity531 :: ('MESH:D013901', 'Disease') :: ['neurovascular coupling']

answer: @entity531 :: (MESH:D013901,Disease) :: ['neurovascular coupling']


abstract: PURPOSE: Recently, a novel multi-model monitor has been available, which integrates real-time signals of transcranial Doppler (TCD) and video-EEG (vEEG) into one workstation. We sought to test the feasibility of this device in detecting @entity531 in @entity1 with @entity302 . METHOD: Cerebral blood flow velocity (CBFV) of bilateral middle cerebral arteries and vEEG during @entity410 episodes were recorded simultaneously in 12 @entity1 (age 17-58 years) with @entity302 . The correlations between vEEG and CBFV findings were analyzed. RESULTS: Eleven @entity410 episodes were detected in 5 @entity1 . Of them, bilateral CBFV increase with interhemispheric asymmetry was observed in 4 @entity410 episodes of 3 @entity1 . EEG abnormalities preceded CBFV increase by 1-3s at the onset of a @entity410 . In a @entity1 with bilateral @entity2500 , no apparent CBFV changes were detected during 2 of 3 @entity410 episodes. Another @entity1 with previous frontal @entity548 displayed CBFV increase without interhemispheric asymmetry during 4 @entity410 episodes. CONCLUSION: It is feasible to evaluate @entity531 with good temporal correlation in @entity1 with frequent @entity410 episodes by real-time TCD-vEEG monitoring.

title: Real-time TCD-vEEG monitoring for @entity531 in XXXX .

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: PURPOSE: This study aimed to chart patterns of simultaneous trajectories over 8  months in @entity0 survivors' (BCS) supportive care needs, @entity458 , social support, and posttraumatic growth. Clusters of BCS among these trajectories were identified and characterized. METHODS: Of 426 BCS study @entity1 , 277 (65  %) provided full assessments in the last week of primary @entity5 treatment and 4 and 8  months later. Latent trajectories were obtained using growth mixture modeling for @entity1 who responded to all scores for at least one time point (n   =   348). Then, classification of BCS was performed by hierarchical agglomerative clustering on axes derived from a multiple factor analysis of trajectory assignments. Self-esteem, attachment security, and satisfaction with care were assessed at baseline. RESULTS: Four trajectory clusters were identified, including two BCS subgroups (63  %) with low needs and @entity258 . Two others (37  %) exhibited high or increasing needs and concerning levels of @entity458 . These latter clusters were characterized by higher insecure attachment, lower satisfaction with care, and either lower education or younger age, and having undergone chemotherapy. CONCLUSION: More than a third of BCS present unfavorable patterns in supportive care needs over 8  months after primary @entity5 treatment. Identified @entity5 care characteristics point to targets for enhanced BCS supportive care.

title: Identifying trajectory clusters in XXXX survivors' supportive care needs, psychosocial difficulties, and resources from the completion of primary treatment to 8  months later.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'psychosocial and cancer']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['low psychological distress']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: The epidemiology of suicidality shows considerable variation across sites. However, one of the strongest predictors of suicide is a suicidal attempt. Knowledge of the epidemiology of suicidal ideas and attempts in the general population as well as in the health care system is of importance for designing preventive strategies. In this study, we will explore the role of the @entity146 hospital in suicide prevention by investigating treated incidence of suicidal ideation and attempt, and further, discern whether sociodemographic, clinical and service utilization factors differ between these two groups at admission. METHODS: The study was a prospective cohort study on treated incidence in a 1-year period and 12-month follow-up. The two @entity146 hospitals in northern Norway, serving a population of about 500,000 @entity1 , participated in the study. A total of 676 first-time admissions were retrospectively checked for suicidality at the time of admission. A study sample of 168 @entity1 was found eligible for logistic regression analysis to elucidate the risk profiles of suicidal ideators versus suicidal attempters. GAF, HoNOS and SCL-90-R were used to assess symptomatology at baseline. RESULTS: 52.2% of all @entity1 admitted had suicidal ideas at admission and 19.7% had attempted suicide. In the study sample, there were no differences in risk profile between the two groups with regard to sociodemographic and clinical factors. Males who had made a suicide attempt were less likely to have been in contact with an out- @entity1 clinic before the attempt. The rating scales not measuring suicidality directly showed no differences in symptomatology. CONCLUSION: The findings provide evidence for the importance of the @entity146 hospital in suicide prevention. About half of the admissions were related to suicidality and the similar risk profiles found in suicidal ideators and suicidal attempters indicate that it is the ideators who mostly need treatment that get admitted to the hospital, and should be evaluated and treated with equal concern as those who have attempted suicide.

title: Suicidality related to first-time admissions to XXXX hospital.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'people', 'patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: The female genital tract (FGT) harbors very large numbers of bacterial species that are known to play an important role on vaginal health. Previous studies have focused on bacterial diversity in the vagina, but little is known about the ectocervical microbiota associated with @entity5860 . In our study, vaginal swabs and ectocervical swabs were collected from 100 @entity1 in China, including 30 @entity1 with @entity6981 ( @entity6981 ; @entity6981 group), 22 @entity1 with @entity3799 (Cer group), 18 @entity1 with @entity6981 in combination with @entity3799 (BC group) and 30 healthy control @entity1 (CN group). The diversity and richness of cervicovaginal microbiota were investigated with culture-independent polymerase chain reaction (PCR)-denaturing gradient gel electrophoresis (DGGE) and quantitative PCR (qPCR) targeting 11 microorganisms that have been associated with @entity5860 . Despite significant interpersonal variations, the PCR-DGGE profiles revealed that vaginal microbiota and ectocervical microbiota were clearly much more complex in the @entity6981 group, while the ectocervical microbiota showed no significant difference between healthy and diseased @entity1 . Using species-specific qPCR, @entity6981 and @entity3799 were significantly associated with a dramatic decrease in Lactobacillus species (p   <   0.05), and potential pathogenic species such as Gardnerella, Atopobium, Eggerthella, Leptotrichia/Sneathia, and Prevotella were more common and in higher copy numbers in @entity6981 than in CN samples (p values ranged from 0.000 to 0.021). No significant differences were observed between healthy and @entity3799 samples (p   >   0.05) in ectocervical microbiota. The total numbers of bacteria were significantly lower in the ectocervix as compared in the vagina (p   <   0.05). Intriguingly, vaginal microbiota from @entity1 with @entity6981 in combination with @entity3799 was quite different from that of @entity1 with @entity6981 or @entity3799 alone. Our study demonstrated that the cervicovaginal microbiota was actively involved in the process of @entity5860 . The predominant bacteria of the cervicovaginal communities were clearly associated with @entity6981 ; however, there was not sufficient evidence that the ectocervical microbiota is directly involved in the development of @entity3799 .

title: Diversity of cervicovaginal microbiota associated with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity5860 :: ('MESH:D060737', 'Disease') :: ['FGT infections']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['cervicitis']

entities_list: @entity6981 :: ('MESH:D016585', 'Disease') :: ['BV', 'bacterial vaginosis']

answer: @entity5860 :: (MESH:D060737,Disease) :: ['female lower genital tract infections']


abstract: The variegated Saintpaulia cultivar Thamires (Saintpaulia sp.), which has pink petals with blue splotches, is generally maintained by leaf cuttings. In contrast, tissue culture-derived progeny of the cultivar showed not only a high percentage of mutants with solid-blue petals but also other solid-color variants, which have not been observed from leaf cuttings. Solid-color phenotypes were inherited stably by their progeny from tissue culture. Petals from each solid-color variant were analyzed by high-performance liquid chromatography and shown to contain different proportions of three main @entity4211 derivatives: @entity65607 , @entity71137 , and @entity65608 . Analysis of @entity3096 3', 5'-hydroxylase (F3'5'H) sequences showed no differences in the coding region among the variants and variegated individuals. However, a transposon belonging to the hAT superfamily was found in the promoter region of variegated individuals, and the presence of transposon-related insertions or deletions correlated with the observed flower-color phenotypes. Solid-blue flower mutants contained 8-base pair (bp) insertions (transposon excision footprints), while solid-pink mutants had 58- to 70-bp insertions, and purple- and deep-purple mutants had 21- and 24-bp deletions, respectively. Real-time reverse transcription polymerase chain reaction (RT-PCR) analysis showed that F3'5'H expression levels correlated with insertions and deletions (indels) caused by hAT excision, resulting in flower-color differences. Our results showed that tissue culture of Saintpaulia 'Thamires' elicits transposon excision, which in turn alters F3'5'H expression levels and flower colors.

title: Tissue culture-induced flower-color changes in Saintpaulia caused by excision of the transposon inserted in the XXXX 3', 5' hydroxylase (F3'5'H) promoter.

entities_list: @entity65608 :: ('MESH:C066957', 'Chemical') :: ['pelargonidin']

entities_list: @entity4211 :: ('MESH:D000872', 'Chemical') :: ['anthocyanin']

entities_list: @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid']

answer: @entity3096 :: (CHEBI:47916,Chemical) :: ['flavonoid']


abstract: A series of 98 @entity1 with a total of 105 @entity7334 were operated on during a 10-year period between 1983 and 1992. We were able to follow up 60 @entity1 with 64 @entity174 an average of 44 months (range, 18-105 months) postoperatively. At the time of follow up, 83.9% of @entity1 had been back to work, 78.6% with the same employer as before. Five of the @entity1 followed up had had to retire from work; each of these had one or more severe coexisting @entity130 . A compromising @entity128 occurred postoperatively in 3 out of 58 @entity1 with @entity6044 , in all cases following surgery with a medial or bilateral approach. In only 1 of the 58 @entity1 followed up after @entity6044 did a @entity281 requiring arthrodesis occur. One @entity1 had sympathetic @entity6865 (Sudeck). A good functional result in the lower ankle joint correlated with a good outcome. In contrast, postoperative improvement of the tuber angle and the degree of @entity4040 seen radiographically did not. We conclude that operative repair of intraarticular calcaneal @entity174 is a procedure that can safely be procedure used to restore the ability to work in the majority of @entity1 . The medial approach should preferably not be used, nor should the metal be extracted from the medial approach if this can be avoided.

title: [Dislocated intra-articular calcaneus XXXX . Long-term follow-up after open reposition and osteosynthesis].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity6044 :: ('MESH:D005596', 'Disease') :: ['closed fractures']

entities_list: @entity4040 :: ('MESH:C537208', 'Disease') :: ['arthrosis']

entities_list: @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury']

entities_list: @entity6865 :: ('MESH:D012019', 'Disease') :: ['reflex dystrophy']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['deep infection']

entities_list: @entity7334 :: ('MESH:D057072', 'Disease') :: ['intra-articular fractures of the os calcis']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: @entity1420 profiles were monitored in @entity1237 housed in single (n = 9) or group (n = 14) pens during winter (JJA) and spring ( @entity73131 ). Normal cycles (n = 97) were < or = 30 days. Extended cycles (n = 45) were > 30 days and, except for one cycle with a persistent corpus luteum, had periovulatory periods of 10 to 20 days (n = 29) or averaging 65.1 days in length (n = 15), mostly characterised by recurrent oestrus and/or occasional transient rises in @entity1420 . The proportion of normal cycles occurring in winter was 87.5% (28/32) and 77.7% (42/54) for @entity1237 in single and group pens respectively, falling to 62.5% (15/24) and 37.5% (12/32) respectively in spring. The distribution of normal vs extended cycles according to season was significant (P < 0.05, single; P < 0.001 group pens). @entity1237 housed communally experienced a greater fall in the percentage of normal cycles in spring, possibly due to increased stress associated with group feeding. Within each season, however, housing per se did not influence the distribution of normal vs extended cycles. For normal cycles, Harvey's Analysis of Variance showed that season was significantly associated with length of the periovulatory period (3.99 days (JJA) vs 5.79 days ( @entity73131 ); P < 0.001), oestrus detection rate (87% (JJA) vs 55% ( @entity73131 ); P < 0.01) and oestrus duration (1.94 days (JJA) vs 1.13 days ( @entity73131 ); P < 0.05). In contrast, luteal phase length was not affected by season, but was significantly associated with housing (16.93 days (single pens) vs 18.32 days (group pens); P < 0.01). The reduction in ovarian activity observed in spring may reflect a seasonal reduction in fertility, possibly linked with increasing temperature and photoperiod.

title: Influence of season and housing on ovarian activity of indigenous XXXX in Zimbabwe.

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone']

answer: @entity1237 :: (9925,Species) :: ['goats']


abstract: The Collaborative Pathology Study is one of the most impressive programs of the Bogalusa Heart Study. Attempts are made to obtain complete and uniform necropsy coverage of all decreased young @entity1 who may have been examined in the Bogalusa Heart Study. Since 1978, autopsy specimens have been collected from 190 deaths, representing 65% of all known deaths in the study age category. The relation of antemortem risk factors for @entity65 to early @entity731 in the aorta and coronary arteries was assessed in those individuals previously examined in the Bogalusa Heart Study (N = 59). Aortic fatty streaks were strongly related to both total and low-density lipoprotein (LDL) @entity165 (r = 0.62, P < 0.0001 for each association), and were inversely correlated with the ratio of high-density lipoprotein (HDL) @entity165 to LDL plus very-low-density lipoprotein (VLDL) @entity165 (r = -0.29, P < 0.01). Coronary artery fatty streaks were associated with elevated total @entity165 , LDL @entity165 , VLDL @entity165 , and systolic blood pressure. Higher levels of LDL and VLDL @entity165 , @entity1674 , systolic and diastolic blood pressure, and a lower ratio of HDL to LDL plus VLDL were found in those @entity1 with coronary artery fibrous plaques. Microscopy offered additional information about the characteristics of the aortic and coronary arterial intimal disease. Histologic observations have confirmed some of the relationships indicated with gross observations and show the complexity of this disease process. These findings emphasize the importance of an approach to preventive cardiology early in life.

title: Risk factors and XXXX in youth autopsy findings of the Bogalusa Heart Study.

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic lesions']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']


abstract: OBJECTIVE: Our purpose was to determine the concentration of calcitonin gene-related peptide, a potent vasodilator, in maternal plasma, fetal plasma, and placental tissue from pregnancies complicated by severe @entity1468 . STUDY DESIGN: The following groups were studied: severe @entity1468 (group 1, n = 21), normal pregnancies matched for mode of delivery (group 2, n = 21), and nonpregnant @entity1 (group 3, n = 17). Maternal venous blood samples were drawn before labor, and fetal venous samples were drawn from the chorionic plate immediately after delivery. Calcitonin gene-related peptide was also quantified in placental tissue samples from 15 @entity1 in group 1 and 15 @entity1 in group 2. Calcitonin gene-related peptide was measured with a sensitive and specific radioimmunoassay. RESULTS: No differences were found between maternal plasma calcitonin gene-related peptide concentrations in groups 1 and 2 (29.8 +/- 4.2 and 30.4 +/- 4.3 pmol/L, respectively). Both had levels similar to those in group 3 (28.5 +/- 5.4 pmol/L). Maternal plasma concentrations in the preeclamptic group were unchanged 3 days post partum (29.1 +/- 3.6 pmol/L). Fetal plasma calcitonin gene-related peptide concentrations were similar in groups 1 and 2 (30.2 +/- 3.9 and 32.2 +/- 8.8 pmol/L, respectively). A significant correlation was found between maternal and fetal calcitonin gene-related peptide concentrations (r = 0.43, p < 0.01). Like plasma levels, calcitonin gene-related peptide levels in the supernatants of placental extracts were not different in preeclamptic and normal pregnancies (108.0 +/- 70.4 and 100.9 +/- 56.1 fmol/gm, respectively). CONCLUSION: On the basis of plasma and placental concentrations, calcitonin gene-related peptide does not seem to play an important role in the pathophysiologic mechanisms of @entity1468 .

title: Plasma and placental calcitonin gene-related peptide in pregnancies complicated by severe XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']

answer: @entity1468 :: (MESH:D011225,Disease) :: ['preeclampsia']


abstract: The blind test-retest reliability of lifetime prevalence and age of onset of @entity146 diagnoses, based on the SADS-L interview and RDC over a three-to-five year period, was examined in 143 probands and their relatives. Reliability of lifetime prevalence of @entity308 was excellent; reliability of @entity10420 , @entity4697 , @entity734 , @entity9372 , @entity308 , and @entity988 was good; reliability of @entity3119 and @entity913 was acceptable but lower. The reliability of hyperthymia or cyclothymia was not acceptable. Reliability for @entity308 did not vary substantially by age or sex of the informant, but recall of @entity308 was significantly higher in the probands than in their relatives. The test-retest reliability for the age of onset of @entity308 and @entity4697 was excellent, and for @entity913 , @entity9372 and @entity988 , was acceptable. Both probands and relatives recalled the age of onset of their @entity308 fairly accurately. However, there was a reduction in agreement over time. Recall after 3-4 yr was better than 5-6 yr. There was a tendency for older respondents to systematically increase the age of onset of their @entity308 across the two interviews, although the increase was only a few years. Recall of age of onset did not differ significantly by sex of respondent or whether the respondent was a proband or relative. These findings are discussed in light of several available studies of reliability of lifetime prevalence of @entity146 diagnoses.

title: Lifetime prevalence and age of onset of XXXX : recall 4 years later.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive personality', 'depression', 'major depression']

entities_list: @entity4697 :: ('MESH:D016584', 'Disease') :: ['panic disorder']

entities_list: @entity10420 :: ('MESH:D000987', 'Disease') :: ['antisocial personality']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity988 :: ('MESH:D000437', 'Disease') :: ['alcoholism']

entities_list: @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive-compulsive disorder']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['drug abuse']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric disorders']


abstract: In T-cells, the Shaker-related gene, @entity2302 encodes the type n K+ channel, whereas the type l channel is a product of the Shaw. subfamily gene, @entity36216 . Both these genes are also expressed in the brain. We have used the @entity1238 oocyte heterologous expression system to study the modulatory effects of @entity750 ( @entity750 , @entity750 ) on both these cloned channels. In oocytes coexpressing the @entity19 @entity36768 receptor and @entity19 @entity2302 channel, addition of 100 nM @entity750 causes a complete and sustained suppression of @entity2302 currents in approximately 20 min. In contrast, @entity750 has no effect on @entity19 @entity36216 currents when coexpressed with @entity36768 receptor. The @entity750 -mediated suppression of @entity2302 currents proceeds via activation of a pertussis toxin-sensitive G protein and a subsequent rise in intracellular @entity141 , but @entity141 does not directly block the channel. @entity10179 ( @entity10179 ) C activation is not part of the pathway linking @entity36768 receptor to @entity2302 channels. However, @entity4996 independently suppress @entity2302 currents. Deletion of the first 146 @entity1522 from the @entity2733 -terminal, containing putative @entity669 kinase and PKA phosphorylation sites, does not alter the time course of @entity750 -mediated suppression of @entity2302 currents, indicating that these residues are not necessary for modulation. Treatment of oocytes with calmodulin or phosphatase inhibitors does not alter @entity750 -mediated modulation. Collectively, these experiments indicate that the @entity19 @entity2302 channel is capable of being modulated by @entity750 via @entity36768 receptor in a G protein and @entity141 -dependent manner, but the subsequent steps in the pathway remain elusive.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Full-length and truncated XXXX K+ channels are modulated by @entity36768 receptor activation and independently by PKC.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['5-hydroxytryptamine', 'serotonin', '5-HT']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity4996 :: ('MESH:D010703', 'Chemical') :: ['phorbol esters']

answer: @entity2302 :: (16491(Tax:10090),Gene) :: ['Kv1.3']


abstract: In T-cells, the Shaker-related gene, @entity2302 encodes the type n K+ channel, whereas the type l channel is a product of the Shaw. subfamily gene, @entity36216 . Both these genes are also expressed in the brain. We have used the @entity1238 oocyte heterologous expression system to study the modulatory effects of @entity750 ( @entity750 , @entity750 ) on both these cloned channels. In oocytes coexpressing the @entity19 @entity36768 receptor and @entity19 @entity2302 channel, addition of 100 nM @entity750 causes a complete and sustained suppression of @entity2302 currents in approximately 20 min. In contrast, @entity750 has no effect on @entity19 @entity36216 currents when coexpressed with @entity36768 receptor. The @entity750 -mediated suppression of @entity2302 currents proceeds via activation of a pertussis toxin-sensitive G protein and a subsequent rise in intracellular @entity141 , but @entity141 does not directly block the channel. @entity10179 ( @entity10179 ) C activation is not part of the pathway linking @entity36768 receptor to @entity2302 channels. However, @entity4996 independently suppress @entity2302 currents. Deletion of the first 146 @entity1522 from the @entity2733 -terminal, containing putative @entity669 kinase and PKA phosphorylation sites, does not alter the time course of @entity750 -mediated suppression of @entity2302 currents, indicating that these residues are not necessary for modulation. Treatment of oocytes with calmodulin or phosphatase inhibitors does not alter @entity750 -mediated modulation. Collectively, these experiments indicate that the @entity19 @entity2302 channel is capable of being modulated by @entity750 via @entity36768 receptor in a G protein and @entity141 -dependent manner, but the subsequent steps in the pathway remain elusive.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Full-length and truncated @entity2302 K+ channels are modulated by XXXX receptor activation and independently by PKC.

answer: @entity36768 :: (15560(Tax:10090),Gene) :: ['5-HT1c']


abstract: We describe 11 @entity1 with a distinctive @entity14253 . Most of the @entity1 were adult @entity1 who presented with a painless mass. Nine @entity5 arose in minor salivary glands of the oral cavity (82%). Microscopically, they were characterized by the formation of trabeculae, cords, islands, and/or nests of monomorphic clear cells that were glycogen rich and mucin negative and were surrounded by hyalinized bands with foci of myxohyaline stroma. Cells with eosinophilic and granular cytoplasm were also noted. Both cell types showed minimal nuclear pleomorphism and a very low mitotic index. The @entity5 all had infiltrative borders. Immunohistochemically, the @entity5 cells expressed cytokeratins and epithelial membrane antigen, but not @entity4483 protein and smooth muscle actin. Ultrastructurally, the @entity5 cells contained abundant glycogen, desmosomes, peripheral tonofilaments, and prominent interdigitating microvilli without actin myofilaments or dense bodies. These immunohistochemical and ultrastructural findings provide evidence of epithelial differentiation without myoepithelial differentiation. For these @entity5 , we propose the name, @entity1358 ( @entity1358 ). These are low-grade malignant @entity5 . Two @entity1 had ipsilateral cervical lymph node @entity3 at presentation, but with surgical excision and either preoperative or post-operative radiotherapy in three cases, eight of 10 @entity1 with clinical follow-up are alive and well without evidence of recurrence. The mean clinical follow-up is 3.6 years, with a range of 6 months to 11 years. One @entity1 died as a result of surgery, another died of unrelated causes, and one @entity1 was lost to follow-up.

title: XXXX of salivary gland.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasms', 'tumors']

entities_list: @entity14253 :: ('MESH:D012468', 'Disease') :: ['salivary gland neoplasm']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['hyalinizing clear cell carcinoma', 'HCCC']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['Hyalinizing clear cell carcinoma']


abstract: The efficacy of @entity396 (a synthetic analogue of @entity5015 ) and @entity4444 in the treatment of @entity2275 was evaluated. Thirty-two @entity1 with endoscopically proven @entity2275 were randomized, in a double-blind manner, in one of three groups that received four daily doses of either @entity396 , 50 or 200 micrograms, or @entity4444 , 300 mg. @entity1066 healing was assessed endoscopically after 4 weeks of treatment. The three groups were fairly comparable in their @entity167 and @entity5834 intake, previous @entity1066 history and @entity1066 size. A relatively high proportion of @entity1 in the @entity4444 -treated group was smokers. Only one @entity1 was withdrawn from the study. On the @entity396 low dose, healing of the @entity1066 was observed in 20% of the @entity1 . In contrast, healing on the high dose of @entity396 (70%) was not significantly different from that on @entity4444 (73%). No important clinical side effects were observed in any of the @entity1 . These results (part of a multicenter, international study) suggest that the divided daily dose of 800 micrograms @entity396 is safe and effective in the short-term treatment of @entity2275 .

title: Comparison of @entity396 and XXXX in the treatment of @entity2275 .

entities_list: @entity4444 :: ('MESH:D002927', 'Chemical') :: ['cimetidine']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity396 :: ('MESH:D016595', 'Chemical') :: ['misoprostol']

entities_list: @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine']

entities_list: @entity5015 :: ('MESH:D000527', 'Chemical') :: ['prostaglandin E1']

entities_list: @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcer']

answer: @entity4444 :: (MESH:D002927,Chemical) :: ['cimetidine']


abstract: The efficacy of @entity396 (a synthetic analogue of @entity5015 ) and @entity4444 in the treatment of @entity2275 was evaluated. Thirty-two @entity1 with endoscopically proven @entity2275 were randomized, in a double-blind manner, in one of three groups that received four daily doses of either @entity396 , 50 or 200 micrograms, or @entity4444 , 300 mg. @entity1066 healing was assessed endoscopically after 4 weeks of treatment. The three groups were fairly comparable in their @entity167 and @entity5834 intake, previous @entity1066 history and @entity1066 size. A relatively high proportion of @entity1 in the @entity4444 -treated group was smokers. Only one @entity1 was withdrawn from the study. On the @entity396 low dose, healing of the @entity1066 was observed in 20% of the @entity1 . In contrast, healing on the high dose of @entity396 (70%) was not significantly different from that on @entity4444 (73%). No important clinical side effects were observed in any of the @entity1 . These results (part of a multicenter, international study) suggest that the divided daily dose of 800 micrograms @entity396 is safe and effective in the short-term treatment of @entity2275 .

title: Comparison of @entity396 and @entity4444 in the treatment of XXXX .

answer: @entity2275 :: (MESH:D013276,Disease) :: ['gastric ulcer']


abstract: The efficacy of @entity396 (a synthetic analogue of @entity5015 ) and @entity4444 in the treatment of @entity2275 was evaluated. Thirty-two @entity1 with endoscopically proven @entity2275 were randomized, in a double-blind manner, in one of three groups that received four daily doses of either @entity396 , 50 or 200 micrograms, or @entity4444 , 300 mg. @entity1066 healing was assessed endoscopically after 4 weeks of treatment. The three groups were fairly comparable in their @entity167 and @entity5834 intake, previous @entity1066 history and @entity1066 size. A relatively high proportion of @entity1 in the @entity4444 -treated group was smokers. Only one @entity1 was withdrawn from the study. On the @entity396 low dose, healing of the @entity1066 was observed in 20% of the @entity1 . In contrast, healing on the high dose of @entity396 (70%) was not significantly different from that on @entity4444 (73%). No important clinical side effects were observed in any of the @entity1 . These results (part of a multicenter, international study) suggest that the divided daily dose of 800 micrograms @entity396 is safe and effective in the short-term treatment of @entity2275 .

title: Comparison of XXXX and @entity4444 in the treatment of @entity2275 .

answer: @entity396 :: (MESH:D016595,Chemical) :: ['misoprostol']


abstract: UNASSIGNED: Widespread use of cross-sectional imaging and increasing age of the general population has increased the number of detected @entity660 . However, several pathological entities with a variety in malignant potential have to be discriminated to allow clinical decision making. Discrimination between mucinous @entity788 ( @entity788 ) and nonmucinous @entity660 is the primary step in the clinical work-up, as malignant transformation is mostly associated with mucinous PCN. We performed a retrospective analysis of all resected PCN in our tertiary center from 2000 to 2014, to evaluate preoperative diagnostic performance and the results of implementation of the consensus guidelines over time. This was followed by a prospective cohort study of @entity1 with an undefined @entity45 , where the added value of cytopathological mucin evaluation to @entity787 ( @entity787 ) in cyst fluid for the discrimination of mucinous PCN and nonmucinous cysts was investigated. Retrospective analysis showed 115 @entity1 operated for a PCN, with a correct preoperative classification in 96.2% of the @entity1 . High-grade @entity1141 or @entity189 was observed in only 32.3% of mucinous PCN. In our prospective cohort (n=71), 57.7% of @entity1 were classified as having a mucinous PCN. @entity787 >= 192ng/mL had an accuracy of 63.4%, and cytopathological mucin evaluation an accuracy of 73.0%. Combining these 2 tests further improved diagnostic accuracy of a mucinous @entity22097 to 76.8%. @entity787 level and mucin evaluation were not predictive of the degree of @entity1141 . These findings show that adding cytopathology to cyst fluid biochemistry improves discrimination between mucinous PCN and nonmucinous cysts.

title: Cytopathological Analysis of Cyst Fluid Enhances Diagnostic Accuracy of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['PCNs', 'pancreatic cystic neoplasms']

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic lesions', 'pancreatic cystic lesions']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma']

entities_list: @entity787 :: ('1084', 'Gene') :: ['carcinoembryonic antigen', 'CEA']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['pancreatic cyst']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity788 :: (MESH:D010190,Disease) :: ['Mucinous Pancreatic Cystic Neoplasms']