abstract: UNASSIGNED: @entity5343 is extremely rare. To investigate the clinical characteristics and further enrich the limited knowledge on its diagnosis and treatment, the present study retrospectively analyzed the detailed clinical data of five @entity1 with primary @entity774 treated in the Peking Union Medical College Hospital (Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China) between March 2009 and February 2014. The five @entity1 were female, aged from 16 to 51 years (mean, 36.0  16.3 years), with solitary lesions that were incidentally found on routine physical examinations. The @entity5 size ranged from 2.4 to 9.0 cm (mean, 6.0  2.7 cm). Ultrasonography revealed a mixed echo in four @entity1 , and computed tomography showed mixed density masses with fat components and calcification in three @entity1 . Adrenal-related endocrine tests were normal in all five @entity1 , and no abnormalities were found in the three @entity1 who underwent @entity1943 receptor scintigraphy examination. All @entity1 were treated with retroperitoneal laparoscopic surgery, with no complications, and the resected @entity5 were identified as mature cystic @entity44 pathologically. To date, the @entity1 have been followed up for 4-60 months post-operatively, with no recurrence. In conclusion, this rare @entity774 is an occult entity to which reproductive females are susceptible. The @entity5 exhibits no typical clinical manifestations or adrenal-related @entity854 , and the pre-operative diagnosis mainly relies on imaging characteristics of a heterogeneous lesion containing fat components with scattered and marginal @entity730 . The preferred treatment is retroperitoneal laparoscopic surgery, and the prognosis is good.

title: XXXX : Clinical characteristics and retroperitoneal laparoscopic resection in five adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcifications']

entities_list: @entity5343 :: ('MESH:D000224', 'Disease') :: ['Primary adrenal teratoma']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['laboratory abnormalities']

entities_list: @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratomas']

entities_list: @entity774 :: ('MESH:D000312', 'Disease') :: ['adrenal teratoma', 'adrenal teratomas']

answer: @entity5343 :: (MESH:D000224,Disease) :: ['Primary adrenal teratoma']


abstract: UNASSIGNED: The present study aimed to investigate the effects of blocking nuclear factor (NF)-kB and/or @entity3963 ( @entity3963 ) signaling pathways on proliferation and apoptosis of @entity320 cells in vitro. A375 @entity1 @entity320 cells were treated with @entity5732 ( @entity3963 signaling pathway inhibitor) and @entity36607 (NF-kB inhibitor), alone or in combination. At 12, 24 and 48 h after treatment, cell viability was assessed using the @entity2454 assay, cell cycle progression and apoptosis were evaluated by flow cytometry, and @entity588 protein content was determined by western blot analysis. @entity36607 and @entity5732 significantly inhibited A375 cell proliferation in a dose- and time-dependent manner (P<0.01). The rate of proliferation inhibition at 24 h was 35.41  1.38% for @entity36607 alone, 30.64  2.86% for @entity5732 alone, and 77.27  2.70% for @entity36607 and @entity5732 in combination. The difference between combination and single treatment was significantly different (P<0.01). The proportion of cells in S phase was 14.20, 18.40 and 22.64% following treatment with @entity36607 , @entity5732 , and @entity36607 and @entity5732 in combination, respectively; these values were all significantly reduced compared with the untreated control group (P<0.01). The apoptosis rate was 24.98  1.03% in the @entity36607 group, 13.96  0.96% in the @entity5732 group and 38.91  1.46% in the combination group; all significantly increased compared with the control group (P<0.01). @entity588 protein content in A375 cells was significantly increased following treatment with @entity36607 and @entity5732 , alone or in combination, when compared with the untreated control group (P<0.01). Therefore, NF-kB and @entity3963 signaling pathway inhibitors may serve as potential therapeutic targets for @entity320 .

title: Effects of nuclear factor-kB and @entity3963 signaling transduction pathway inhibitors on @entity1 XXXX cell proliferation in vitro.

entities_list: @entity3963 :: ('5594', 'Gene') :: ['extracellular signal-regulated kinase', 'ERK']

entities_list: @entity2454 :: ('MESH:C022616', 'Chemical') :: ['3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['melanoma']


abstract: UNASSIGNED: The present study aimed to investigate the effects of blocking nuclear factor (NF)-kB and/or @entity3963 ( @entity3963 ) signaling pathways on proliferation and apoptosis of @entity320 cells in vitro. A375 @entity1 @entity320 cells were treated with @entity5732 ( @entity3963 signaling pathway inhibitor) and @entity36607 (NF-kB inhibitor), alone or in combination. At 12, 24 and 48 h after treatment, cell viability was assessed using the @entity2454 assay, cell cycle progression and apoptosis were evaluated by flow cytometry, and @entity588 protein content was determined by western blot analysis. @entity36607 and @entity5732 significantly inhibited A375 cell proliferation in a dose- and time-dependent manner (P<0.01). The rate of proliferation inhibition at 24 h was 35.41  1.38% for @entity36607 alone, 30.64  2.86% for @entity5732 alone, and 77.27  2.70% for @entity36607 and @entity5732 in combination. The difference between combination and single treatment was significantly different (P<0.01). The proportion of cells in S phase was 14.20, 18.40 and 22.64% following treatment with @entity36607 , @entity5732 , and @entity36607 and @entity5732 in combination, respectively; these values were all significantly reduced compared with the untreated control group (P<0.01). The apoptosis rate was 24.98  1.03% in the @entity36607 group, 13.96  0.96% in the @entity5732 group and 38.91  1.46% in the combination group; all significantly increased compared with the control group (P<0.01). @entity588 protein content in A375 cells was significantly increased following treatment with @entity36607 and @entity5732 , alone or in combination, when compared with the untreated control group (P<0.01). Therefore, NF-kB and @entity3963 signaling pathway inhibitors may serve as potential therapeutic targets for @entity320 .

title: Effects of nuclear factor-kB and XXXX signaling transduction pathway inhibitors on @entity1 @entity320 cell proliferation in vitro.

answer: @entity3963 :: (5594,Gene) :: ['ERK']


abstract: UNASSIGNED: The present study aimed to investigate the effects of blocking nuclear factor (NF)-kB and/or @entity3963 ( @entity3963 ) signaling pathways on proliferation and apoptosis of @entity320 cells in vitro. A375 @entity1 @entity320 cells were treated with @entity5732 ( @entity3963 signaling pathway inhibitor) and @entity36607 (NF-kB inhibitor), alone or in combination. At 12, 24 and 48 h after treatment, cell viability was assessed using the @entity2454 assay, cell cycle progression and apoptosis were evaluated by flow cytometry, and @entity588 protein content was determined by western blot analysis. @entity36607 and @entity5732 significantly inhibited A375 cell proliferation in a dose- and time-dependent manner (P<0.01). The rate of proliferation inhibition at 24 h was 35.41  1.38% for @entity36607 alone, 30.64  2.86% for @entity5732 alone, and 77.27  2.70% for @entity36607 and @entity5732 in combination. The difference between combination and single treatment was significantly different (P<0.01). The proportion of cells in S phase was 14.20, 18.40 and 22.64% following treatment with @entity36607 , @entity5732 , and @entity36607 and @entity5732 in combination, respectively; these values were all significantly reduced compared with the untreated control group (P<0.01). The apoptosis rate was 24.98  1.03% in the @entity36607 group, 13.96  0.96% in the @entity5732 group and 38.91  1.46% in the combination group; all significantly increased compared with the control group (P<0.01). @entity588 protein content in A375 cells was significantly increased following treatment with @entity36607 and @entity5732 , alone or in combination, when compared with the untreated control group (P<0.01). Therefore, NF-kB and @entity3963 signaling pathway inhibitors may serve as potential therapeutic targets for @entity320 .

title: Effects of nuclear factor-kB and @entity3963 signaling transduction pathway inhibitors on XXXX @entity320 cell proliferation in vitro.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Introduction   In @entity394 ( @entity394 ), caloric tests allow evaluation of @entity425 ( @entity425 ) and directional preponderance (DP), where different criteria of normality are adopted in Brazil and worldwide. The Brazilian version of the Dizziness Handicap Inventory (Brazilian DHI) evaluates the impact of @entity1296 on the quality of life of an individual. Objectives   The objective of this research is to evaluate the impact of @entity1296 on the quality of life of @entity1 undergoing @entity394 , and to relate these findings to the results obtained according to national and international criteria. Methods   Cross-sectional analytic study of 235 @entity1 referred for @entity394 in two hospitals. The authors performed the Brazilian DHI, history, static, and dynamic balance tests, positional @entity346 , and the Dix-Hallpike maneuver, as well as vectoelectronystagmography. Subjects were divided into three groups according to @entity425 and DP values. Descriptive statistics and comparisons between groups were performed, considering a significance level of 5% in all analyses. Results   @entity1 groups had 20.9% @entity1 , and 79.1% @entity1 . There was no significant difference between groups for the scores obtained in the Brazilian DHI. There was, however, a statistically significant difference in the redistribution of individuals according to the @entity425 and DP values. Conclusion   There was no relationship between @entity394 results and the impact of @entity1296 in the quality of life. A review of normal values for @entity425 and DP adopted in Brazil is suggested, as well as the application of the Brazilian DHI as an additional tool to evaluate the impact of @entity1296 on quality of life in all @entity1 undergoing @entity394 .

title: The Impact of Dizziness on the Quality of Life of 235 Individuals who Completed XXXX in Brazil.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['unilateral weakness', 'UW']

entities_list: @entity346 :: ('MESH:D009759', 'Disease') :: ['nystagmus']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity394 :: ('MESH:D015837', 'Disease') :: ['VT', 'Vestibular Testing']

answer: @entity394 :: (MESH:D015837,Disease) :: ['Vestibular Testing']


abstract: UNASSIGNED: Understanding how @entity311 parasites gain entry into @entity1 red blood cells is essential for developing strategies to stop blood stage infection. @entity3965 preferentially invades reticulocytes, which are immature red blood cells. The organism has two erythrocyte-binding protein families: namely, the Duffy-binding protein (PvDBP) and the reticulocyte-binding protein (PvRBP) families. Several members of the PvRBP family bind reticulocytes, specifically suggesting a role in mediating host cell selectivity of @entity3965 . Here, we present, to our knowledge, the first high-resolution crystal structure of an erythrocyte-binding domain from PvRBP2a, solved at 2.12    resolution. The monomeric molecule consists of 10 a-helices and one short b-hairpin, and, although the structural fold is similar to that of PfRh5-the essential invasion ligand in @entity3964 -its surface properties are distinct and provide a possible mechanism for recognition of alternate receptors. Sequence alignments of the crystallized fragment of PvRBP2a with other PvRBPs highlight the conserved placement of @entity1520 bonds. PvRBP2a binds mature red blood cells through recognition of an erythrocyte receptor that is neuraminidase- and chymotrypsin-resistant but trypsin-sensitive. By examining the patterns of sequence diversity within field isolates, we have identified and mapped polymorphic residues to the PvRBP2a structure. Using mutagenesis, we have also defined the critical residues required for erythrocyte binding. Characterization of the structural features that govern functional erythrocyte binding for the PvRBP family provides a framework for generating new tools that block @entity3965 blood stage infection.

title: Structurally conserved erythrocyte-binding domain in XXXX provides a versatile scaffold for alternate receptor engagement.

entities_list: @entity3965 :: ('5855', 'Species') :: ['P. vivax', 'Plasmodium vivax']

entities_list: @entity1520 :: ('CHEBI:48343', 'Chemical') :: ['disulfide']

entities_list: @entity3964 :: ('5833', 'Species') :: ['Plasmodium falciparum']

answer: @entity3964 :: (5833,Species) :: ['Plasmodium']


abstract: BACKGROUND: Disturbed circadian rhythms have been associated with @entity308 and @entity148 , but it is unclear if disturbances in the 24-hr activity rhythm and sleep are independently and specifically related to these disorders. METHODS: In 1,714 middle-aged and elderly @entity1 of the Rotterdam Study, we collected actigraphy recordings of at least 96 hr (138    14 hr, mean    standard deviation). Activity rhythms were quantified calculating the fragmentation of the rhythm, stability of the rhythm over days, and timing of the rhythm. Total sleep time, sleep onset latency, and wake after sleep onset were also estimated with actigraphy. @entity308 symptoms were assessed with the Center for Epidemiologic Studies @entity308 scale, @entity1 with clinically relevant @entity308 were interviewed to diagnose @entity308 . @entity148 were determined with the Munich version of the Composite International Diagnostic Interview. RESULTS: More fragmented rhythms were associated with clinically relevant @entity308 (odds ratio (OR): 1.27, 95% confidence interval (CI): 1.04;1.54) and @entity148 (OR: 1.39, 95% CI: 1.14;1.70) after covariate adjustment. Less stable rhythms, longer sleep onset latency, and more wake after sleep onset were related to clinically relevant @entity308 or @entity148 only if not adjusted for covariates and other activity rhythm and sleep indicators. CONCLUSIONS: Our study in middle-aged and elderly @entity1 suggests that fragmentation of the 24-hr activity rhythm is associated with @entity308 and @entity148 . Moreover, this association also largely accounts for the effect of disturbed sleep on these @entity146 .

title: 24-HOUR ACTIVITY RHYTHM AND SLEEP DISTURBANCES IN DEPRESSION AND ANXIETY: A POPULATION-BASED STUDY OF MIDDLE-AGED AND OLDER XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'persons']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depressive', 'Depression', 'depressive symptoms', 'DSM-IV-depressive disorder', 'depression']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'Anxiety disorders', 'anxiety disorders']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders']

answer: @entity1 :: (9606,Species) :: ['PERSONS']


abstract: AIM: To validate the association between atypical endoscopic features and @entity1600 ( @entity1600 ). METHODS: A total of 247 @entity1 with @entity8799 (NETs) were analyzed. Endoscopic images were reviewed independently by two endoscopists, each of whom classified @entity5 by sized and endoscopic features, such as shape, color, and surface change (kappa coefficient 0.76 for inter-observer agreement). All of @entity1 underwent computed tomography scans of abdomen and pelvis for evaluation of @entity1600 . Univariate and multivariate analyses were performed to identify the factors associated with @entity1600 . Additionally, the association between endoscopic atypical features and immunohistochemical staining of @entity5 was analyzed. RESULTS: Of 247 @entity1 , 156 (63.2%) were male and 15 (6.1%) were showed positive for @entity1600 . On univariate analysis, @entity5 size (P < 0.001), shape (P < 0.001), color (P < 0.001) and surface changes (P < 0.001) were significantly associated with @entity1600 . On multivariate analysis, @entity5 size (OR = 11.53, 95%CI: 2.51-52.93, P = 0.002) and atypical surface (OR = 27.44, 95%CI: 5.96-126.34, P < 0.001) changes were independent risk factors for @entity1600 . The likelihood of atypical endoscopic features increased as @entity5 size increased. Atypical endoscopic features were associated with @entity1600 in rectal NETs < 10 mm (P = 0.005) and 10-19 mm (P = 0.041) in diameter. Immunohistochemical staining showed that the rate of atypical endoscopic features was higher in non L-cell @entity5 . CONCLUSION: Atypical endoscopic features as well as @entity5 size are predictive factors of @entity1600 in @entity1 with rectal NETs.

title: Clinical impact of atypical endoscopic features in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis', 'LNM']

entities_list: @entity8799 :: ('MESH:D018358', 'Disease') :: ['rectal neuroendocrine tumors']

answer: @entity8799 :: (MESH:D018358,Disease) :: ['rectal neuroendocrine tumors']


abstract: AIM: To investigate the progression rate of small @entity660 and identify characteristics associated with their progression. METHODS: @entity1 with @entity660 with at least 1-year of follow-up were evaluated retrospectively. We excluded @entity1 with cysts larger than 3 cm or with features that were a concern for malignancy. In total, 135 @entity1 were evaluated. The interval progression of the cysts was examined. Characteristics were compared between @entity1 with and without progression. RESULTS: The @entity45 ranged from 3 to 29 mm. The mean follow-up period was 4.5    2.3 years and the mean progression rate was 1.0    1.3 mm/year. Ninety @entity1 showed interval progression and were divided into two groups; the minimal-change group (n = 41), who had cyst progression at less than 1 mm/year, and the progression group (n = 49), who had a progression rate of more than 1 mm/year. Compared with the cysts without progression, the lesions of the progression group were more frequently associated with tubular cyst, septation or a prominent pancreatic duct (P < 0.05). The odds ratio for progression was 5.318 for septation and 4.582 for tubular cysts. CONCLUSION: Small @entity45 progress slowly. Lesions with tubular shape, septa, or prominent pancreatic duct were more likely to progress, and required further diagnostic intervention or shorter surveillance interval.

title: Features associated with progression of small XXXX : A retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic cystic lesions']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['pancreatic cysts']

answer: @entity660 :: (MESH:D010182,Disease) :: ['pancreatic cystic lesions']


abstract: UNASSIGNED: @entity14911 ( @entity14912 ) and @entity5248 ( @entity5248 ) have both been reported to induce adverse effects including immunotoxicity. Despite the widespread presence of these two chemicals in estuaries and seawater, their health effects on marine fish have received little attention. Oryzias melastigma is a potential marine fish model for immunological studies. In the present study, immune-related genes in O.  melastigma were enriched at the transcriptome level. Three-month-old fish were exposed to @entity14912 and @entity5248 (single or combined) for one week. The liver index-hepatosomatic index (HSI) of the fish was higher in the @entity14912 -exposed group and combined group than in the control group. This result indicates that @entity14912 might lead to liver @entity137 . The mRNA level of @entity1356 ( @entity1356 ) was upregulated after exposure. For catalase (CAT), @entity2041 peroxidase (GPx) and cluster of differentiation 3 (CD3), single exposure did not affect mRNA levels, but the combined exposure did significantly alter the expression of these genes. In all, our study provides a useful reference for immunotoxicological studies with O.  melastigma; it also highlights the importance of assessing the combined effects of pollutant mixtures when determining the risk to aquatic organisms.

title: Immunotoxic effects of XXXX and @entity5248 on the marine fish Oryzias melastigma.

entities_list: @entity14911 :: ('MESH:C076994', 'Chemical') :: ['Perfluorooctane sulfonate']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5248 :: ('MESH:D004051', 'Chemical') :: ['DEHP', 'di(2-ethylhexyl) phthalate']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

answer: @entity14911 :: (MESH:C076994,Chemical) :: ['perfluorooctane sulfonate']


abstract: UNASSIGNED: @entity14911 ( @entity14912 ) and @entity5248 ( @entity5248 ) have both been reported to induce adverse effects including immunotoxicity. Despite the widespread presence of these two chemicals in estuaries and seawater, their health effects on marine fish have received little attention. Oryzias melastigma is a potential marine fish model for immunological studies. In the present study, immune-related genes in O.  melastigma were enriched at the transcriptome level. Three-month-old fish were exposed to @entity14912 and @entity5248 (single or combined) for one week. The liver index-hepatosomatic index (HSI) of the fish was higher in the @entity14912 -exposed group and combined group than in the control group. This result indicates that @entity14912 might lead to liver @entity137 . The mRNA level of @entity1356 ( @entity1356 ) was upregulated after exposure. For catalase (CAT), @entity2041 peroxidase (GPx) and cluster of differentiation 3 (CD3), single exposure did not affect mRNA levels, but the combined exposure did significantly alter the expression of these genes. In all, our study provides a useful reference for immunotoxicological studies with O.  melastigma; it also highlights the importance of assessing the combined effects of pollutant mixtures when determining the risk to aquatic organisms.

title: Immunotoxic effects of @entity14911 and XXXX on the marine fish Oryzias melastigma.

answer: @entity5248 :: (MESH:D004051,Chemical) :: ['di(2-ethylhexyl) phthalate']


abstract: BACKGROUND: Various parts of Pandanus foetidus Roxb. are used as traditional medicines. However, scientific reports concerning the effect of this plant on central nervous system (CNS) @entity308 and @entity1337 are unavailable. This study investigated the CNS depressant and antinociceptive effects of Pandanus foetidus leaf extracts in a rodent model. METHODS: The sedative and anxiolytic activities of Pandanus foetidus extract (500 g) were tested using behavioural models of Swiss albino @entity19 , and the analgesic activity was assessed by @entity406 -induced @entity158 and tail immersion tests at 200 mg/kg body weight of the @entity19 . The data were analysed by a one-way ANOVA, a repeated measure of ANOVA and a non-parametric test (Kruskal-Wallis test) using the SPSS software. Acute @entity137 was tested using an established method. RESULTS: Compared with the aqueous fraction, the @entity1042 , @entity8144 and @entity3636 fractions of the extract exhibited a more significant (P < 0.001) @entity2915 in the @entity19 in the open field, hole-cross, and elevated plus maze (EPM). The @entity1042 fraction maximized the duration of sleeping time caused by the thiopental @entity1372 induction. The extract produced a significant step-down in @entity158 , as shown by the paw licking time in the early and late phases of the @entity406 test. In the tail immersion test, the @entity3636 fraction maximally reduced the heat-induced @entity1337 . The extract was found to be non toxic. CONCLUSION: The @entity1042 , @entity8144 , and @entity3636 fractions of P. foetidus have strong CNS depressant and antinociceptive effects and thus merit further pharmaceutical studies.

title: CNS Depressant and Antinociceptive Effects of Different Fractions of Pandanus Foetidus Roxb. Leaf Extract in XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity3636 :: ('MESH:D002725', 'Chemical') :: ['chloroform']

entities_list: @entity8144 :: ('MESH:C004544', 'Chemical') :: ['petroleum ether']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['reduction of locomotor activity']

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: BACKGROUND: @entity27 ( @entity27 ) is a highly prevalent @entity25 that is associated with increased risk of @entity101 ( @entity101 ) and @entity301 . This study aimed to evaluate the correlation between the @entity27 and @entity453 ( @entity453 ) severity. METHODS: The cross-sectional study was conducted from September 2012 to December 2013. We enrolled 127 @entity1 with @entity5749 who were referred for coronary angiographic studies in Shahid Chamran and Nour Hospitals in Isfahan, Iran. The Berlin questionnaire (BQ) was used for estimate the probability of @entity27 in @entity1 as a low or high probability. Demographic characteristics and metabolic risk factors including @entity6 , @entity101 , @entity28 , and smoking also were recorded. The severity of @entity453 was assessed and compared based on the Gensini score with Mann-Whitney U statistical test. Independent t-test for continuous variables and chi-square test for categorical variables were used. RESULTS: Totally, 65.4% of subjects were considered as high and 34.6% as low probability for @entity27 , which 81.1% of them had @entity453 . There was a significant difference between body mass index, systolic blood pressure, diastolic blood pressure, and @entity63 heart disease drug consumption with @entity27 probability (P < 0.0500). @entity453 was accompanied by @entity27 significantly (P = 0.0260). The Gensini score was significantly higher in @entity1 with high @entity27 probability (100.4    69.1 vs. 65.3    68.9; P = 0.0030). @entity27 also increase odds of @entity453 based on regression analysis (odds ratio, 95% confidence interval = 2.7). CONCLUSION: This study indicates that more severe @entity453 is associated with high @entity27 probability identified by BQ.

title: Obstructive sleep apnea, diagnosed by the Berlin questionnaire and association with XXXX severity.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'HTN']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['OSAS', 'Obstructive sleep apnea syndrome']

entities_list: @entity5749 :: ('MESH:D060050', 'Disease') :: ['chronic stable angina']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep-related disorder']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: BACKGROUND: It is critical to follow up @entity157 ( @entity157 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4831 deposition, whereas it is difficult to @entity5 masked by @entity4831 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity5 , but cannot display @entity4831 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4831 deposition and @entity5 for @entity157 @entity1 after TACE. @entity1 AND METHODS: Ten @entity157 @entity1 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity1496 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity1 . They were found in @entity1496 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity1496 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity1496 -based material decomposition images of spectral CT in assessment of both @entity4831 deposition and @entity5 for follow-up of @entity157 @entity1 previously treated with TACE.

title: Assessment of XXXX Deposition and @entity5 for @entity157 After Transcatheter Arterial Chemoembolization via @entity1496 -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['residual cancer', 'assess hypovascular residual cancer']

entities_list: @entity4831 :: ('MESH:D004998', 'Chemical') :: ['lipiodol']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity4831 :: (MESH:D004998,Chemical) :: ['Lipiodol']


abstract: BACKGROUND: It is critical to follow up @entity157 ( @entity157 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4831 deposition, whereas it is difficult to @entity5 masked by @entity4831 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity5 , but cannot display @entity4831 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4831 deposition and @entity5 for @entity157 @entity1 after TACE. @entity1 AND METHODS: Ten @entity157 @entity1 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity1496 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity1 . They were found in @entity1496 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity1496 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity1496 -based material decomposition images of spectral CT in assessment of both @entity4831 deposition and @entity5 for follow-up of @entity157 @entity1 previously treated with TACE.

title: Assessment of @entity4831 Deposition and @entity5 for @entity157 After Transcatheter Arterial Chemoembolization via XXXX -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

answer: @entity1496 :: (MESH:D007455,Chemical) :: ['Iodine']


abstract: BACKGROUND: It is critical to follow up @entity157 ( @entity157 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4831 deposition, whereas it is difficult to @entity5 masked by @entity4831 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity5 , but cannot display @entity4831 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4831 deposition and @entity5 for @entity157 @entity1 after TACE. @entity1 AND METHODS: Ten @entity157 @entity1 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity1496 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity1 . They were found in @entity1496 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity1496 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity1496 -based material decomposition images of spectral CT in assessment of both @entity4831 deposition and @entity5 for follow-up of @entity157 @entity1 previously treated with TACE.

title: Assessment of @entity4831 Deposition and XXXX for @entity157 After Transcatheter Arterial Chemoembolization via @entity1496 -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

answer: @entity5 :: (MESH:D009369,Disease) :: ['Residual Cancer']


abstract: BACKGROUND: It is critical to follow up @entity157 ( @entity157 ) after transcatheter arterial chemoembolization (TACE) in clinical practice. Computed tomography (CT) is used to assess @entity4831 deposition, whereas it is difficult to @entity5 masked by @entity4831 . In contrast, magnetic resonance imaging (MRI) is superior to CT in showing @entity5 , but cannot display @entity4831 deposition. OBJECTIVES: The aim of this study was to investigate the value of spectral CT imaging in both @entity4831 deposition and @entity5 for @entity157 @entity1 after TACE. @entity1 AND METHODS: Ten @entity157 @entity1 after treated with TACE underwent Discovery CT750 HD and MRI750 3T examination. Receiver operating characteristic (ROC) curves of @entity1496 -based material decomposition images, monochromatic images and conventional CT images were generated. RESULTS: Consequently, 30 residual lesions were detected in MRI of 10 @entity1 . They were found in @entity1496 -based images and monochromatic images versus 29 in conventional CT images. The area under ROC curves for the lesion-to-normal parenchyma ratio (LNR) on arterial phase (AP) in @entity1496 -based material decomposition images, monochromatic images and conventional CT images were 0.933, 0.833 and 0.817, respectively. CONCLUSION: The study data highlighted good value of @entity1496 -based material decomposition images of spectral CT in assessment of both @entity4831 deposition and @entity5 for follow-up of @entity157 @entity1 previously treated with TACE.

title: Assessment of @entity4831 Deposition and @entity5 for XXXX After Transcatheter Arterial Chemoembolization via @entity1496 -Based Material Decomposition Images with Spectral Computed Tomography Imaging: A Preliminary Study.

answer: @entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']


abstract: Studies with selective lesions of cerebral structures have revealed the involvement of @entity750 in sleep and wakefulness. However, the mechanisms underlying the role of @entity750 remain obscure. An appreciation of the interrelationships between @entity750 and other transmitter systems might lead to a better understanding of the functions subserved by @entity750 . A serotoninergic projection from the median raph   nucleus to @entity935 neurons in the substantia nigra has been reported. We have therefore investigated the possible influence of the raph   system on the nigro striatal @entity935 pathway in the @entity35 using the "turning" model described by UNGERSTEDT (1971). An unilateral lesion in the median raph   nucleus induces contralateral turning similar to that observed following @entity3826 administration to @entity35 with a unilaterally degenerated nigro striatal pathway. Similarly, unilateral application of 2.5 micrograms of @entity10105 to the median raph   nucleus of normal @entity35 also provokes contralateral turning. On the other hand, unilateral injection of @entity10105 into the zona compacta of the substantia nigra induces turning ipsilateral to the site of injection. The above results, and also those from several experiments in which @entity3826 or @entity10105 was applied systematically, suggest that @entity750 neurons in the median raph   nucleus exert an inhibitory influence on the dopaminergic nigro striatal system. These studies demonstrate that the serotoninergic median raph   system, in addition to its involvement in sleep and wakefulness, also exerts an important influence on motor functions.

title: [Involvement of serotoninergic mechanisms in the circling behaviour induced by XXXX and @entity10105 in @entity35 (author's transl)].

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity3826 :: ('MESH:D001058', 'Chemical') :: ['apomorphine']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

answer: @entity3826 :: (MESH:D001058,Chemical) :: ['apomorphine']


abstract: Studies with selective lesions of cerebral structures have revealed the involvement of @entity750 in sleep and wakefulness. However, the mechanisms underlying the role of @entity750 remain obscure. An appreciation of the interrelationships between @entity750 and other transmitter systems might lead to a better understanding of the functions subserved by @entity750 . A serotoninergic projection from the median raph   nucleus to @entity935 neurons in the substantia nigra has been reported. We have therefore investigated the possible influence of the raph   system on the nigro striatal @entity935 pathway in the @entity35 using the "turning" model described by UNGERSTEDT (1971). An unilateral lesion in the median raph   nucleus induces contralateral turning similar to that observed following @entity3826 administration to @entity35 with a unilaterally degenerated nigro striatal pathway. Similarly, unilateral application of 2.5 micrograms of @entity10105 to the median raph   nucleus of normal @entity35 also provokes contralateral turning. On the other hand, unilateral injection of @entity10105 into the zona compacta of the substantia nigra induces turning ipsilateral to the site of injection. The above results, and also those from several experiments in which @entity3826 or @entity10105 was applied systematically, suggest that @entity750 neurons in the median raph   nucleus exert an inhibitory influence on the dopaminergic nigro striatal system. These studies demonstrate that the serotoninergic median raph   system, in addition to its involvement in sleep and wakefulness, also exerts an important influence on motor functions.

title: [Involvement of serotoninergic mechanisms in the circling behaviour induced by @entity3826 and XXXX in @entity35 (author's transl)].

answer: @entity10105 :: (MESH:D008238,Chemical) :: ['LSD 25']


abstract: Studies with selective lesions of cerebral structures have revealed the involvement of @entity750 in sleep and wakefulness. However, the mechanisms underlying the role of @entity750 remain obscure. An appreciation of the interrelationships between @entity750 and other transmitter systems might lead to a better understanding of the functions subserved by @entity750 . A serotoninergic projection from the median raph   nucleus to @entity935 neurons in the substantia nigra has been reported. We have therefore investigated the possible influence of the raph   system on the nigro striatal @entity935 pathway in the @entity35 using the "turning" model described by UNGERSTEDT (1971). An unilateral lesion in the median raph   nucleus induces contralateral turning similar to that observed following @entity3826 administration to @entity35 with a unilaterally degenerated nigro striatal pathway. Similarly, unilateral application of 2.5 micrograms of @entity10105 to the median raph   nucleus of normal @entity35 also provokes contralateral turning. On the other hand, unilateral injection of @entity10105 into the zona compacta of the substantia nigra induces turning ipsilateral to the site of injection. The above results, and also those from several experiments in which @entity3826 or @entity10105 was applied systematically, suggest that @entity750 neurons in the median raph   nucleus exert an inhibitory influence on the dopaminergic nigro striatal system. These studies demonstrate that the serotoninergic median raph   system, in addition to its involvement in sleep and wakefulness, also exerts an important influence on motor functions.

title: [Involvement of serotoninergic mechanisms in the circling behaviour induced by @entity3826 and @entity10105 in XXXX (author's transl)].

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: UNASSIGNED: There are limited data to guide the choice of @entity34 ( @entity34 ) regimen before autologous hematopoietic cell transplantation (AHCT) for @entity1 with Hodgkin ( @entity1733 ) and @entity1893 ( @entity1893 ). We studied 4917 @entity1 ( @entity1893 , n  = 3905; @entity1733 , n  = 1012) who underwent AHCT from 1995 to 2008 using the most common @entity34 platforms: carmustine (BCNU), etoposide, cytarabine, and melphalan (BEAM) (n  = 1730); cyclophosphamide, BCNU, and etoposide (CBV) (n  = 1853); busulfan and cyclophosphamide (BuCy) (n  = 789); and @entity348 ( @entity348 )-containing treatment (n  = 545). CBV was divided into CBV(high) and CBV(low) based on BCNU dose. We analyzed the impact of regimen on development of @entity358 ( @entity358 ), transplantation-related mortality (TRM), and progression-free and overall survival. The 1-year incidence of @entity358 was 3% to 6% and was highest in recipients of CBV(high) (hazard ratio [HR], 1.9) and @entity348 (HR, 2.0) compared with BEAM. One-year TRM was 4% to 8%, respectively, and was similar between regimens. Among @entity1 with @entity1893 , there was a significant interaction between histology, @entity34 regimen, and outcome. Compared with BEAM, CBV(low) (HR, .63) was associated with lower mortality in @entity706 (P < .001), and CBV(high) (HR, 1.44) was associated with higher mortality in diffuse large B cell lymphoma (P  = .001). For @entity1 with @entity1733 , CBV(high) (HR, 1.54), CBV(low) (HR, 1.53), BuCy (HR, 1.77), and @entity348 (HR, 3.39) were associated with higher mortality compared with BEAM (P < .001). The impact of specific AHCT regimen on post-transplantation survival is different depending on histology; therefore, further studies are required to define the best regimen for specific diseases.

title: Impact of Conditioning Regimen on Outcomes for @entity1 with XXXX Undergoing High-Dose Therapy with Autologous Hematopoietic Cell Transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['follicular lymphoma']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['IPS', 'idiopathic pulmonary syndrome']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['total body irradiation', 'TBI']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphoma']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['high-dose therapy', 'HDT']

answer: @entity706 :: (MESH:D008223,Disease) :: ['Lymphoma']


abstract: UNASSIGNED: There are limited data to guide the choice of @entity34 ( @entity34 ) regimen before autologous hematopoietic cell transplantation (AHCT) for @entity1 with Hodgkin ( @entity1733 ) and @entity1893 ( @entity1893 ). We studied 4917 @entity1 ( @entity1893 , n  = 3905; @entity1733 , n  = 1012) who underwent AHCT from 1995 to 2008 using the most common @entity34 platforms: carmustine (BCNU), etoposide, cytarabine, and melphalan (BEAM) (n  = 1730); cyclophosphamide, BCNU, and etoposide (CBV) (n  = 1853); busulfan and cyclophosphamide (BuCy) (n  = 789); and @entity348 ( @entity348 )-containing treatment (n  = 545). CBV was divided into CBV(high) and CBV(low) based on BCNU dose. We analyzed the impact of regimen on development of @entity358 ( @entity358 ), transplantation-related mortality (TRM), and progression-free and overall survival. The 1-year incidence of @entity358 was 3% to 6% and was highest in recipients of CBV(high) (hazard ratio [HR], 1.9) and @entity348 (HR, 2.0) compared with BEAM. One-year TRM was 4% to 8%, respectively, and was similar between regimens. Among @entity1 with @entity1893 , there was a significant interaction between histology, @entity34 regimen, and outcome. Compared with BEAM, CBV(low) (HR, .63) was associated with lower mortality in @entity706 (P < .001), and CBV(high) (HR, 1.44) was associated with higher mortality in diffuse large B cell lymphoma (P  = .001). For @entity1 with @entity1733 , CBV(high) (HR, 1.54), CBV(low) (HR, 1.53), BuCy (HR, 1.77), and @entity348 (HR, 3.39) were associated with higher mortality compared with BEAM (P < .001). The impact of specific AHCT regimen on post-transplantation survival is different depending on histology; therefore, further studies are required to define the best regimen for specific diseases.

title: Impact of Conditioning Regimen on Outcomes for XXXX with @entity706 Undergoing High-Dose Therapy with Autologous Hematopoietic Cell Transplantation.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Previous studies suggest that @entity8779 / @entity2592 (ara-C)/ @entity8673 (IAP) is an active salvage regimen for @entity1 with @entity3052 . We therefore investigated this regimen in @entity1 with newly-diagnosed @entity3052 or @entity4289 (>= 10% blasts). @entity1 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity1 received @entity8673 (1,280 mg/day po; days 1-8), @entity2592 (1.5 g/m(2) /day; days 4-7), and @entity8779 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity66 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity1 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity1 were included. Conventional CR was achieved in 15 (63%) @entity1 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity1 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity1 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity1 died within 28 days from @entity177 . The most common grade 3-4 adverse effects were @entity1398 (75%) and @entity294 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity1 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity1 subset.

title: XXXX , @entity2592 , and @entity8673 as induction therapy for untreated @entity3052 and high-risk myelodysplastic syndrome.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

entities_list: @entity8779 :: ('MESH:D015255', 'Chemical') :: ['idarubicin']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['multiorgan failure']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['febrile neutropenia']

entities_list: @entity8673 :: ('MESH:D017035', 'Chemical') :: ['pravastatin']

answer: @entity8779 :: (MESH:D015255,Chemical) :: ['Idarubicin']


abstract: Previous studies suggest that @entity8779 / @entity2592 (ara-C)/ @entity8673 (IAP) is an active salvage regimen for @entity1 with @entity3052 . We therefore investigated this regimen in @entity1 with newly-diagnosed @entity3052 or @entity4289 (>= 10% blasts). @entity1 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity1 received @entity8673 (1,280 mg/day po; days 1-8), @entity2592 (1.5 g/m(2) /day; days 4-7), and @entity8779 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity66 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity1 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity1 were included. Conventional CR was achieved in 15 (63%) @entity1 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity1 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity1 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity1 died within 28 days from @entity177 . The most common grade 3-4 adverse effects were @entity1398 (75%) and @entity294 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity1 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity1 subset.

title: @entity8779 , XXXX , and @entity8673 as induction therapy for untreated @entity3052 and high-risk myelodysplastic syndrome.

answer: @entity2592 :: (MESH:D003561,Chemical) :: ['cytarabine']


abstract: Previous studies suggest that @entity8779 / @entity2592 (ara-C)/ @entity8673 (IAP) is an active salvage regimen for @entity1 with @entity3052 . We therefore investigated this regimen in @entity1 with newly-diagnosed @entity3052 or @entity4289 (>= 10% blasts). @entity1 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity1 received @entity8673 (1,280 mg/day po; days 1-8), @entity2592 (1.5 g/m(2) /day; days 4-7), and @entity8779 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity66 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity1 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity1 were included. Conventional CR was achieved in 15 (63%) @entity1 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity1 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity1 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity1 died within 28 days from @entity177 . The most common grade 3-4 adverse effects were @entity1398 (75%) and @entity294 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity1 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity1 subset.

title: @entity8779 , @entity2592 , and @entity8673 as induction therapy for untreated XXXX and high-risk myelodysplastic syndrome.

answer: @entity3052 :: (MESH:D015470,Disease) :: ['acute myeloid leukemia']


abstract: Previous studies suggest that @entity8779 / @entity2592 (ara-C)/ @entity8673 (IAP) is an active salvage regimen for @entity1 with @entity3052 . We therefore investigated this regimen in @entity1 with newly-diagnosed @entity3052 or @entity4289 (>= 10% blasts). @entity1 were eligible if the anticipated treatment-related mortality (TRM) was <10%. @entity1 received @entity8673 (1,280 mg/day po; days 1-8), @entity2592 (1.5 g/m(2) /day; days 4-7), and @entity8779 (12 mg/m(2) /day, days 4-6). Up to 3 cycles of consolidation with a shortened course was permitted. The primary endpoints were "good CR" rate (CR on day 35 without minimal @entity66 ) and TRM in the first 28 days. The study was to stop if after each cohort of 5 @entity1 (a) the Bayesian posterior probability was   <   5% that the true "good CR rate" was   >=    70% or (b) the posterior probability was >25% that the TRM rate was >= 5%. Twenty-four @entity1 were included. Conventional CR was achieved in 15 (63%) @entity1 but only 12 (50%) achieved "good CR". 4 of 12 (33%) @entity1 with "good CR" relapsed at median of 16 weeks (10.5-19). Five (21%) @entity1 had refractory disease. Survival probability at 1 year was 72% (48.7-64). Two (8.3%) @entity1 died within 28 days from @entity177 . The most common grade 3-4 adverse effects were @entity1398 (75%) and @entity294 (25%). Based on the stopping rules accrual ceased after entry of these 24 @entity1 . IAP did not meet the predefined efficacy criteria for success. Therefore, we would not recommend this regimen for phase three testing in this @entity1 subset.

title: @entity8779 , @entity2592 , and XXXX as induction therapy for untreated @entity3052 and high-risk myelodysplastic syndrome.

answer: @entity8673 :: (MESH:D017035,Chemical) :: ['pravastatin']


abstract: UNASSIGNED: Sections of fecal cylinders were analyzed using fluorescence in situ hybridization targeting 180 bacterial groups. Samples were collected from three groups of @entity1 (N=20 each) treated for @entity6981 with @entity2177 + @entity868 . Group A only received the combined antibiotic regimen, whereas the A/Sb group received concomitant @entity375 boulardii CNCM I-745 treatment, and the A_Sb group received S. boulardii prophylaxis following the 14-day antibiotic course. The number of stool cylinders analyzed was 188 out of 228 in group A, 170 out of 228 in group A/Sb, and 172 out of 216 in group A_Sb. The colonic biomass was organized into a separate mucus layer with no bacteria, a 10-30 m broad unstirred transitional layer enriched with bacteria, and a patchy fermentative area that mixed digestive leftovers with bacteria. The antibiotics suppressed bacteria mainly in the fermentative area, whereas abundant bacterial clades retreated to the transitional mucus and survived. As a result, the total concentration of bacteria decreased only by one order. These effects were lasting, since the overall recovery of the microbial mass, bacterial diversity and concentrations were still below pre-antibiotic values 4 months after the end of antibiotic treatment. Sb-prophylaxis markedly reduced antibiotic effects and improved the recovery rates. Since the colon is a sophisticated bioreactor, the study indicated that the spatial anatomy of its biomass was crucial for its function.

title: Functional anatomy of the colonic bioreactor: Impact of antibiotics and XXXX boulardii on bacterial composition in @entity1 fecal cylinders.

entities_list: @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity6981 :: ('MESH:D016585', 'Disease') :: ['bacterial vaginosis']

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces']

answer: @entity375 :: (4932,Species) :: ['Saccharomyces']


abstract: UNASSIGNED: Sections of fecal cylinders were analyzed using fluorescence in situ hybridization targeting 180 bacterial groups. Samples were collected from three groups of @entity1 (N=20 each) treated for @entity6981 with @entity2177 + @entity868 . Group A only received the combined antibiotic regimen, whereas the A/Sb group received concomitant @entity375 boulardii CNCM I-745 treatment, and the A_Sb group received S. boulardii prophylaxis following the 14-day antibiotic course. The number of stool cylinders analyzed was 188 out of 228 in group A, 170 out of 228 in group A/Sb, and 172 out of 216 in group A_Sb. The colonic biomass was organized into a separate mucus layer with no bacteria, a 10-30 m broad unstirred transitional layer enriched with bacteria, and a patchy fermentative area that mixed digestive leftovers with bacteria. The antibiotics suppressed bacteria mainly in the fermentative area, whereas abundant bacterial clades retreated to the transitional mucus and survived. As a result, the total concentration of bacteria decreased only by one order. These effects were lasting, since the overall recovery of the microbial mass, bacterial diversity and concentrations were still below pre-antibiotic values 4 months after the end of antibiotic treatment. Sb-prophylaxis markedly reduced antibiotic effects and improved the recovery rates. Since the colon is a sophisticated bioreactor, the study indicated that the spatial anatomy of its biomass was crucial for its function.

title: Functional anatomy of the colonic bioreactor: Impact of antibiotics and @entity375 boulardii on bacterial composition in XXXX fecal cylinders.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: PURPOSE: This study investigated the relationship between family composition and the prevalence of @entity209 by gender in Korean adults aged 45 years and older. METHODS: The sample consisted of 11,291 @entity1 in the Korea National Health and Nutrition Examination Survey from 2010 to 2012. We used complex sample analyses, including strata, cluster, and sample weighting, to allow generalization to the Korean population. Complex samples crosstabs and chi-square tests were conducted to compare the percentage of sociodemographic characteristics to the prevalence of @entity209 and its components by gender and family composition. Next, a complex sample logistic regression was performed to examine the association between family composition and the prevalence of @entity209 by gender. RESULTS: The percentage of adults living alone was 5.6% for @entity1 and 13.9% for @entity1 . Slightly more @entity1 (14.0%) than @entity1 (10.1%) reported living with three generations. The percentage of @entity209 in Korean adults aged 45 years and older was 53.2% for @entity1 and 35.7% for @entity1 . For @entity1 , we found that living with one or three generations was significantly associated with a higher risk of @entity209 , blood pressure, and @entity412 abnormality after adjusting for age, education, household income, smoking, physical activity, and body mass index, when compared to living alone. No significant relationships were found for @entity1 . CONCLUSIONS: A national strategy, tailored on gender and family composition, needs to be developed in order to prevent the increase of @entity209 in Korean @entity1 over middle age.

title: Association of Family Composition and XXXX in Korean Adults Aged over 45 Years Old.

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

answer: @entity209 :: (MESH:D008659,Disease) :: ['Metabolic Syndrome']


abstract: BACKGROUND AND STUDY AIMS: Magnifying narrow-band imaging (NBI) is more useful than conventional endoscopy for diagnosing early @entity356 (EGC). However, evaluation of irregular microvascular patterns is subjective and is often difficult, even with expert eyes. The aim of this study was to clarify the most important microvascular patterns in magnifying NBI for diagnosis of EGC. @entity1 AND METHODS: This was a post-hoc analysis of a multicenter prospective trial among nine Japanese hospitals. A total of 1353 @entity1 underwent screening with white-light endoscopy and 362 @entity1 had small ( <=10mm) @entity308 . They were randomly assigned to magnifying NBI or white-light endoscopy followed by magnifying NBI. During diagnosis, magnifying NBI images were recorded before biopsy. All magnifying NBI images were reviewed and evaluated for the association of four features of microvessels - that is, dilation, tortuosity, difference in caliber, and variation in shape - with @entity5 diagnosis. RESULTS: Images of 343 lesions (40 cancerous and 303 benign @entity308 ) were evaluable. The diagnostic performance (sensitivity/specificity) of each finding was: dilation, 25/90%; tortuosity, 55/24%; difference in caliber, 13/99%; and variation in shape, 70/95%. Multivariate analysis identified only variation in shape as being statistically significantly associated with diagnosis of @entity5 (odds ratio 38.0, 95% confidence interval: 16.1-95.7, P<0.001). All findings showed moderate agreement (k values): dilation, 0.44; tortuosity, 0.33; difference in caliber, 0.26; and variation in shape, 0.48. CONCLUSIONS: A variation in shape was the most significant feature of microvessels observed in magnifying NBI for diagnosis of small depressed-type EGC. STUDY REGISTRATION: UMIN-CTR000001072.

title: A significant feature of microvessels in magnifying narrow-band imaging for diagnosis of early XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression lesions', 'depressed lesions']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: UNASSIGNED: The @entity2151 reductase  M2 subunit ( @entity16071 ) modulates the enzymatic activity of @entity2151 reductase, and is involved in @entity5 progression. Recently, high levels of @entity16071 expression were reported to correlate with poor survival outcomes in @entity1 with @entity14 . However, changes in @entity16071 expression in @entity189 ( @entity189 ), and its effect on the prognosis of this disease remain unknown. The aim of the present study was to analyze the expression of @entity16071 in @entity189 cell lines, and to identify whether @entity16071 may serve as a biomarker with which to assess the prognosis of @entity189 . The present study found that @entity16071 expression was higher in @entity189 cell lines and tissue samples than in noncancerous nasopharyngeal epithelial cell lines and noncancerous tissues, as shown by reverse transcription  -quantitative polymerase chain reaction analysis, western blotting and immunohistochemistry staining. Kaplan  -Meier survival analysis demonstrated that @entity1 with higher @entity16071 expression levels had poorer disease  -free survival outcomes than those with lower expression levels of @entity16071 . Univariate analysis showed that a lower survival rate was significantly associated with high @entity16071 expression levels [hazard ratio (HR),  6.424; 95%  confidence interval  (CI),  2.381  -17.333; P<0.001]. Multivariate analysis indicated that @entity16071 expression is an independent prognostic factor for @entity1 with @entity189 (HR, 3.461; 95 % CI, 1.204  -9.949; P=0.021). Overexpression of @entity16071 led to increased cell proliferation, colony formation, migration and invasion in  vivo. These results suggest that high levels of @entity16071 expression may be a useful predictor for survival in @entity1 with @entity189 and may serve as a novel prognostic indicator for these individuals.

title: @entity2151 reductase  M2 subunit expression and prognostic value in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal and bladder cancer']

entities_list: @entity2151 :: ('CHEBI:26561', 'Chemical') :: ['ribonucleotide']

answer: @entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']


abstract: UNASSIGNED: The @entity2151 reductase  M2 subunit ( @entity16071 ) modulates the enzymatic activity of @entity2151 reductase, and is involved in @entity5 progression. Recently, high levels of @entity16071 expression were reported to correlate with poor survival outcomes in @entity1 with @entity14 . However, changes in @entity16071 expression in @entity189 ( @entity189 ), and its effect on the prognosis of this disease remain unknown. The aim of the present study was to analyze the expression of @entity16071 in @entity189 cell lines, and to identify whether @entity16071 may serve as a biomarker with which to assess the prognosis of @entity189 . The present study found that @entity16071 expression was higher in @entity189 cell lines and tissue samples than in noncancerous nasopharyngeal epithelial cell lines and noncancerous tissues, as shown by reverse transcription  -quantitative polymerase chain reaction analysis, western blotting and immunohistochemistry staining. Kaplan  -Meier survival analysis demonstrated that @entity1 with higher @entity16071 expression levels had poorer disease  -free survival outcomes than those with lower expression levels of @entity16071 . Univariate analysis showed that a lower survival rate was significantly associated with high @entity16071 expression levels [hazard ratio (HR),  6.424; 95%  confidence interval  (CI),  2.381  -17.333; P<0.001]. Multivariate analysis indicated that @entity16071 expression is an independent prognostic factor for @entity1 with @entity189 (HR, 3.461; 95 % CI, 1.204  -9.949; P=0.021). Overexpression of @entity16071 led to increased cell proliferation, colony formation, migration and invasion in  vivo. These results suggest that high levels of @entity16071 expression may be a useful predictor for survival in @entity1 with @entity189 and may serve as a novel prognostic indicator for these individuals.

title: XXXX reductase  M2 subunit expression and prognostic value in @entity189 .

answer: @entity2151 :: (CHEBI:26561,Chemical) :: ['Ribonucleotide']


abstract: Hepatic stellate cells (HSCs) play an important role in liver @entity82 and @entity101 . This study established a new @entity35 HSC cell line LSC-1. Liver ex vivo perfusion with collagenase IV and density gradient centrifugation were used to isolate @entity35 HSC. Cells have been maintained in culture for multiple passages. LSC-1 cell biological characteristics were studied. LSC-1 cell have been maintained in culture over 100 passages. This new HSC cell line express telomerase reverse transcriptase (TRT) and @entity10740 , suggesting that it is immortalized spontaneously. LSC-1 cells have a doubling time of 46 hours and their growth is serum-dependent. Karyotypic analysis revealed that LSC-1 cells possess normal chromosome phenotype. Moreover, LSC-1 cells do not grow in soft agar or induce @entity5 in @entity19 , suggesting that they are not transformed. LSC-1 cells express desmin, glial fibrillary acidic proteins (GFAP), collagen type I and III, a-smooth muscle actin (a-SMA), @entity1810 ( @entity1810 ), @entity672 ( @entity672 ) and inducible @entity842 synthase (iNOS). @entity1810 stimulation increased collagen type I and III expression in LSC-1 cells. Additionally, LSC-1 cells proliferate in response to PDGF-BB, and contract in response to @entity1827 (ET-1). In summary, LSC-1 cells exhibit activated HSC phenotype characteristics, and therefore are useful tool to study the pathogenesis of liver @entity82 and @entity101 .

title: Establishment and characterization of an immortalized XXXX hepatic stellate cell line.

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['portal hypertension']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['transforming growth factor b1', 'TGF-b1']

entities_list: @entity672 :: ('24628(Tax:10116)', 'Gene') :: ['platelet derived growth factor B', 'PDGF-B']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVES:: We aim to characterize a group of @entity1 with eosinophilic @entity2883 with @entity2883 (EGPA) with an initial presentation of @entity1897 . METHODS:: A retrospective analysis of 11 @entity1 with EGPA. RESULTS:: The most common chief complaint was @entity9 and @entity1183 (100%), followed by @entity425 (82%). Nine (82%) @entity1 had acute to subacute onset. All @entity1 had a history of @entity565 and serum @entity1712 of more than 11%. Combining clinical and electrophysiological data, 10 (91%) @entity1 demonstrated notable asymmetric involvement, whereas 1 @entity1 presented with a length-dependent symmetrical axonal @entity305 . All @entity1 improved significantly after immunotherapy, with average time to improvement of 9 weeks. Ten (91%) @entity1 improved steadily and experienced no relapse, whereas 1 relapsed within the first year. CONCLUSIONS:: EGPA should be suspected in @entity1 with asymmetric @entity1897 associated with @entity565 and @entity1712 . Early diagnosis and aggressive treatment help to achieve favorable outcome.

title: Eosinophilic Granulomatosis With @entity2883 (Churg-Strauss Syndrome) Presenting With XXXX -A Case Series.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity305 :: ('MESH:D011115', 'Disease') :: ['polyneuropathy']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['extremity weakness']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['axonal peripheral neuropathy', 'peripheral neuropathy']

entities_list: @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic limb pain']

answer: @entity305 :: (MESH:D011115,Disease) :: ['Polyneuropathy']


abstract: OBJECTIVES:: We aim to characterize a group of @entity1 with eosinophilic @entity2883 with @entity2883 (EGPA) with an initial presentation of @entity1897 . METHODS:: A retrospective analysis of 11 @entity1 with EGPA. RESULTS:: The most common chief complaint was @entity9 and @entity1183 (100%), followed by @entity425 (82%). Nine (82%) @entity1 had acute to subacute onset. All @entity1 had a history of @entity565 and serum @entity1712 of more than 11%. Combining clinical and electrophysiological data, 10 (91%) @entity1 demonstrated notable asymmetric involvement, whereas 1 @entity1 presented with a length-dependent symmetrical axonal @entity305 . All @entity1 improved significantly after immunotherapy, with average time to improvement of 9 weeks. Ten (91%) @entity1 improved steadily and experienced no relapse, whereas 1 relapsed within the first year. CONCLUSIONS:: EGPA should be suspected in @entity1 with asymmetric @entity1897 associated with @entity565 and @entity1712 . Early diagnosis and aggressive treatment help to achieve favorable outcome.

title: Eosinophilic Granulomatosis With XXXX (Churg-Strauss Syndrome) Presenting With @entity305 -A Case Series.

answer: @entity2883 :: (MESH:D014890,Disease) :: ['Polyangiitis']


abstract: @entity9 caused by nervous system @entity66 . The pathogenesis and the mechanism underlying @entity9 remains unclear. The only known neurobiological component involved in the @entity9 is @entity842 (NO). NO is synthesized by @entity842 synthase ( @entity5612 ) from @entity8561 and @entity26 . @entity5612 is involved in the @entity158 and @entity9 . In this study, we aimed to identify whether @entity14374 reduced the @entity158 in the @entity35 . Sixty adult male SD @entity35 were randomly divided into 4 groups. Sham group and model group were not received treatment. Experimental group received intrathecal injection of @entity14374 , and negative control group received @entity3733 injection 30 min before @entity158 test. After last test of @entity158 threshold, the @entity35 were sacrificed and lumbar spinal tissues were sampled for analysis of the expression of pnNOS and pCaMK II by quantitative PCR and Western blotting. @entity158 threshold was increased in the @entity35 received @entity14374 treatment (P<0.01), and the expression levels of pnNOS was increased (P<0.05) in experimental group and accompanied with decrease of CaMK II expression (P<0.05). By administration of @entity14374 , the interaction of @entity5612 and the adaptor protein @entity71541 was reduced through inhibition of CaMK II by @entity14374 . In conclusion, this study reveals that @entity14374 can reduce @entity9 via inhibiting the activity of CaMK II, and then increase the level of phosphorylated @entity5612 , to reduce the interaction with @entity71541 .

title: Phosphorylated neuronal XXXX synthase in @entity9 in @entity35 .

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['damage or system dysfunction']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['inflammatory pain', 'Pain', 'pain']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'Neuropathic pain']

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: @entity9 caused by nervous system @entity66 . The pathogenesis and the mechanism underlying @entity9 remains unclear. The only known neurobiological component involved in the @entity9 is @entity842 (NO). NO is synthesized by @entity842 synthase ( @entity5612 ) from @entity8561 and @entity26 . @entity5612 is involved in the @entity158 and @entity9 . In this study, we aimed to identify whether @entity14374 reduced the @entity158 in the @entity35 . Sixty adult male SD @entity35 were randomly divided into 4 groups. Sham group and model group were not received treatment. Experimental group received intrathecal injection of @entity14374 , and negative control group received @entity3733 injection 30 min before @entity158 test. After last test of @entity158 threshold, the @entity35 were sacrificed and lumbar spinal tissues were sampled for analysis of the expression of pnNOS and pCaMK II by quantitative PCR and Western blotting. @entity158 threshold was increased in the @entity35 received @entity14374 treatment (P<0.01), and the expression levels of pnNOS was increased (P<0.05) in experimental group and accompanied with decrease of CaMK II expression (P<0.05). By administration of @entity14374 , the interaction of @entity5612 and the adaptor protein @entity71541 was reduced through inhibition of CaMK II by @entity14374 . In conclusion, this study reveals that @entity14374 can reduce @entity9 via inhibiting the activity of CaMK II, and then increase the level of phosphorylated @entity5612 , to reduce the interaction with @entity71541 .

title: Phosphorylated neuronal @entity842 synthase in XXXX in @entity35 .

answer: @entity9 :: (MESH:D009437,Disease) :: ['neuropathic pain']


abstract: @entity9 caused by nervous system @entity66 . The pathogenesis and the mechanism underlying @entity9 remains unclear. The only known neurobiological component involved in the @entity9 is @entity842 (NO). NO is synthesized by @entity842 synthase ( @entity5612 ) from @entity8561 and @entity26 . @entity5612 is involved in the @entity158 and @entity9 . In this study, we aimed to identify whether @entity14374 reduced the @entity158 in the @entity35 . Sixty adult male SD @entity35 were randomly divided into 4 groups. Sham group and model group were not received treatment. Experimental group received intrathecal injection of @entity14374 , and negative control group received @entity3733 injection 30 min before @entity158 test. After last test of @entity158 threshold, the @entity35 were sacrificed and lumbar spinal tissues were sampled for analysis of the expression of pnNOS and pCaMK II by quantitative PCR and Western blotting. @entity158 threshold was increased in the @entity35 received @entity14374 treatment (P<0.01), and the expression levels of pnNOS was increased (P<0.05) in experimental group and accompanied with decrease of CaMK II expression (P<0.05). By administration of @entity14374 , the interaction of @entity5612 and the adaptor protein @entity71541 was reduced through inhibition of CaMK II by @entity14374 . In conclusion, this study reveals that @entity14374 can reduce @entity9 via inhibiting the activity of CaMK II, and then increase the level of phosphorylated @entity5612 , to reduce the interaction with @entity71541 .

title: Phosphorylated neuronal @entity842 synthase in @entity9 in XXXX .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: The effects of @entity8903 , a vasodilator, on blood pressure and heart rate, were tested in 13 ambulant @entity1 with mild to severe @entity101 . The @entity1 received @entity8903 in total oral doses ranging from 1.5 to 4 mg/kg over a 3-5 day period. Standard laboratory tests were done 24 h before and after the study. Standing and supine blood pressure and heart rate were determined before, and every hour for 6-8 h after drug administration. ECGs were recorded before, during and at the end of each study day. @entity8903 reduced the pretreatment standing and supine-blood pressure from 213 +/- 34/126 +/- 21 mmHg and 218 +/- 31/130 +/- 20 mmHg to 156 +/- 33/85 +/- 9 mmHg and 158 +/- 25/88 +/- 11 mmHg at the end of Day 5. Heart rate was only transiently increased in @entity1 with pretreatment values of less than 90 beats/min. Although abnormal ECGs tended towards normalization, there were 2 cases of T-wave inversion (the @entity1 remained asymptomatic). Raised BUN levels tended to decrease towards normal. Side effects reported spontaneously by @entity1 ( @entity10 , palpitations, @entity1296 , @entity390 and one case of water retention) appeared to be transient in nature. @entity8903 appeared to be a very potent and long lasting antihypertensive agent, whose inherent side effects were only transient in nature.

title: Antihypertensive effects of a novel peripheral vasodilator, XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches']

answer: @entity8903 :: (MESH:C028934,Chemical) :: ['Ro 12-4713']


abstract: UNASSIGNED: @entity174 increase the risk of posttraumatic @entity625 and thus the risk of @entity572 ( @entity572 ). We previously presented the ten-year results of @entity572 performed for posttraumatic @entity625 after an @entity174 ; we now present the twenty-year outcomes. The original publication included sixty-six @entity1 who underwent @entity572 between 1970 and 1993 for posttraumatic @entity625 after open reduction and internal fixation (ORIF) of an @entity174 . Clinical outcomes, implant survivorship, radiographic results, and complications were evaluated. A total of thirty-six @entity1 had died. The mean Harris hip score was 80 at the latest follow-up. Nineteen acetabular and/or femoral components had been revised: eleven for @entity1349 , seven for @entity3061 , and one for instability. Twenty-year survivorship of the acetabular component was 71% free from revision for @entity1349 and 57% free from revision for any reason. @entity572 after ORIF of an @entity174 was associated with fair implant survivorship at twenty years after surgery. It is possible that newer implants with improved fixation surfaces and bearing materials may enhance long-term results, as the most common reasons for failure at twenty years were @entity1349 and @entity3061 . LEVEL OF EVIDENCE: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.

title: Total Hip Arthroplasty After Operatively Treated XXXX : A Concise Follow-up, at a Mean of Twenty Years, of a Previous Report.

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['acetabular fracture', 'Acetabular fractures']

entities_list: @entity3061 :: ('MESH:D010014', 'Disease') :: ['osteolysis']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['aseptic loosening']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Acetabular Fracture']


abstract: BACKGROUND AND AIMS: Middle ear surgery requires bloodless surgical field for better operating conditions, deep level of anaesthesia and rapid emergence. Recent studies suggest that a2 agonists could provide desired surgical field, sedation and @entity1337 . The present study was aimed to evaluate the clinical effects of @entity6948 infusion as anaesthetic adjuvant during middle ear surgery using operating microscope. METHODS: Sixty four adult @entity1 aged 18-58 years, American Society of Anaesthesiologists Grades I and II, of both gender were randomised into two comparable equal groups of 32 @entity1 each for middle ear surgery under general anaesthesia with standard anaesthetic technique. After induction of general anaesthesia, @entity1 of Group I were given @entity6948 infusion of 0.5  g/kg/h and @entity1 of Group II were given placebo infusion of normal saline. @entity5161 concentration was titrated to achieve a systolic blood pressure 30% below the baseline value. All @entity1 were assessed intra-operatively for @entity548 at surgical field, haemodynamic changes, awakening time and post-operative recovery. RESULTS: Statistically significant reduction was observed in the required percentage of @entity5161 (0.8    0.6%) to maintain the systolic blood pressure 30% below the baseline values in @entity1 receiving @entity6948 infusion when compared to those receiving placebo infusion (1.6    0.7%). @entity1 receiving @entity6948 infusion had statistically significant lesser @entity548 at surgical field (P < 0.05). The mean awakening time and recovery from anaesthesia did not show any significant difference between the groups. CONCLUSION: @entity6948 infusion can be safely used to provide oligaemic surgical field for better visualization using operating microscope for middle ear surgery.

title: XXXX infusion during middle ear surgery under general anaesthesia to provide oligaemic surgical field: A prospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity5161 :: ('MESH:D007530', 'Chemical') :: ['Isoflurane', 'isoflurane']

entities_list: @entity6948 :: ('MESH:D020927', 'Chemical') :: ['dexmedetomidine', 'Dexmedetomidine']

answer: @entity6948 :: (MESH:D020927,Chemical) :: ['Dexmedetomidine']


abstract: Invasive @entity2583 in @entity1 with @entity1503 mostly occurs in the lungs. Invasive @entity2583 of other anatomical sites is relatively infrequent and its pathogenesis has not so far been well elucidated. Here, we describe an autopsy case of @entity2 complicated by @entity999 with @entity1188 . A 77-year-old Japanese @entity1 with relapsed @entity3052 complained of left visual disturbance and weakness of the lower limbs. The diagnosis of @entity2617 to the central nervous system was made. Repeated intrathecal injection of @entity1499 plus @entity2592 resulted in partial amelioration of the @entity16 . However, the @entity1 then developed @entity221 , @entity1353 , and subsequent @entity1269 . A computed tomography (CT) scan showed a consolidative shadow with halo sign in the left lung field, which was compatible with either invasive @entity57 or @entity2583 . These findings accounted for @entity221 and @entity1353 , but not @entity1269 . Despite antifungal therapy, the @entity1 succumbed to @entity204 after two weeks. Autopsy revealed @entity2 with a fungal ball in the lumina of the adjacent ascending aorta. Intriguingly, autopsy and postmortem CT scan identified left @entity385 due to @entity2583 , which accounted for the @entity1269 . It is likely that the fungal ball caused the @entity999 through @entity6831 . We should suspect @entity6831 when we see a @entity1 with @entity2 developing @entity16 .

title: XXXX through @entity6831 of pulmonary mucormycosis complicating relapsed leukemia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'woman', 'patients']

entities_list: @entity2583 :: ('MESH:D009091', 'Disease') :: ['mucormycosis']

entities_list: @entity57 :: ('MESH:D055732', 'Disease') :: ['pulmonary aspergillosis']

entities_list: @entity2617 :: ('MESH:D017254', 'Disease') :: ['leukemic infiltration']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['right hemiparesis', 'hemiparesis']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic symptoms']

entities_list: @entity999 :: ('MESH:D020766', 'Disease') :: ['cerebral embolism']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['pulmonary invasive mucormycosis']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematological diseases']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine']

entities_list: @entity6831 :: ('MESH:D004673', 'Disease') :: ['hematogenous dissemination']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarct']

answer: @entity999 :: (MESH:D020766,Disease) :: ['Cerebral embolism']


abstract: Invasive @entity2583 in @entity1 with @entity1503 mostly occurs in the lungs. Invasive @entity2583 of other anatomical sites is relatively infrequent and its pathogenesis has not so far been well elucidated. Here, we describe an autopsy case of @entity2 complicated by @entity999 with @entity1188 . A 77-year-old Japanese @entity1 with relapsed @entity3052 complained of left visual disturbance and weakness of the lower limbs. The diagnosis of @entity2617 to the central nervous system was made. Repeated intrathecal injection of @entity1499 plus @entity2592 resulted in partial amelioration of the @entity16 . However, the @entity1 then developed @entity221 , @entity1353 , and subsequent @entity1269 . A computed tomography (CT) scan showed a consolidative shadow with halo sign in the left lung field, which was compatible with either invasive @entity57 or @entity2583 . These findings accounted for @entity221 and @entity1353 , but not @entity1269 . Despite antifungal therapy, the @entity1 succumbed to @entity204 after two weeks. Autopsy revealed @entity2 with a fungal ball in the lumina of the adjacent ascending aorta. Intriguingly, autopsy and postmortem CT scan identified left @entity385 due to @entity2583 , which accounted for the @entity1269 . It is likely that the fungal ball caused the @entity999 through @entity6831 . We should suspect @entity6831 when we see a @entity1 with @entity2 developing @entity16 .

title: @entity999 through XXXX of pulmonary mucormycosis complicating relapsed leukemia.

answer: @entity6831 :: (MESH:D004673,Disease) :: ['hematogenous dissemination']


abstract: @entity565 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity28 could increase the risk of @entity565 , and insulin resistance, or @entity209 are an important risk factor for @entity28 @entity565 . Some studies identified that upstream of the transcription start site within the @entity310 gene promoter region-308 polymorphism was associated insulin resistance or @entity209 , while this site was closely related to @entity565 . But no research was performed to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Here, we recruited 248 @entity748 @entity1 , who were separated into @entity565 with Mets/ @entity565 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Single nucleotide polymorphism of @entity310 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity40610 did not show significant difference between @entity748 @entity1 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity565 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity1 and genotype of @entity310 @entity15646 , we found levels of LDL @entity165 , @entity310 and insulin, and HOMA-IR were significantly higher in the @entity748 @entity1 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity40610 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity310 @entity15646 variation was related to metabolic phenotype in @entity565 @entity1 . Furthermore, we first identified @entity310 -308 A allele was the risk factor for @entity748 @entity1 with Mets in Hebei population, China.

title: Genetic polymorphisms of the @entity310 @entity15646 are associated with XXXX in @entity748 @entity1 from Hebei province, China.

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma', 'Asthma']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome', 'metabolic disorders']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']


abstract: @entity565 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity28 could increase the risk of @entity565 , and insulin resistance, or @entity209 are an important risk factor for @entity28 @entity565 . Some studies identified that upstream of the transcription start site within the @entity310 gene promoter region-308 polymorphism was associated insulin resistance or @entity209 , while this site was closely related to @entity565 . But no research was performed to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Here, we recruited 248 @entity748 @entity1 , who were separated into @entity565 with Mets/ @entity565 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Single nucleotide polymorphism of @entity310 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity40610 did not show significant difference between @entity748 @entity1 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity565 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity1 and genotype of @entity310 @entity15646 , we found levels of LDL @entity165 , @entity310 and insulin, and HOMA-IR were significantly higher in the @entity748 @entity1 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity40610 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity310 @entity15646 variation was related to metabolic phenotype in @entity565 @entity1 . Furthermore, we first identified @entity310 -308 A allele was the risk factor for @entity748 @entity1 with Mets in Hebei population, China.

title: Genetic polymorphisms of the @entity310 XXXX are associated with @entity209 in @entity748 @entity1 from Hebei province, China.

answer: @entity15646 :: (c|SUB|G|-308|A,DNAMutation) :: ['-308G/A']


abstract: @entity565 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity28 could increase the risk of @entity565 , and insulin resistance, or @entity209 are an important risk factor for @entity28 @entity565 . Some studies identified that upstream of the transcription start site within the @entity310 gene promoter region-308 polymorphism was associated insulin resistance or @entity209 , while this site was closely related to @entity565 . But no research was performed to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Here, we recruited 248 @entity748 @entity1 , who were separated into @entity565 with Mets/ @entity565 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Single nucleotide polymorphism of @entity310 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity40610 did not show significant difference between @entity748 @entity1 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity565 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity1 and genotype of @entity310 @entity15646 , we found levels of LDL @entity165 , @entity310 and insulin, and HOMA-IR were significantly higher in the @entity748 @entity1 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity40610 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity310 @entity15646 variation was related to metabolic phenotype in @entity565 @entity1 . Furthermore, we first identified @entity310 -308 A allele was the risk factor for @entity748 @entity1 with Mets in Hebei population, China.

title: Genetic polymorphisms of the XXXX @entity15646 are associated with @entity209 in @entity748 @entity1 from Hebei province, China.

answer: @entity310 :: (7124,Gene) :: ['TNF-a']


abstract: @entity565 is a complex inflammatory disease involving the critical actions of several important cytokines. Epidemiological data show that @entity28 could increase the risk of @entity565 , and insulin resistance, or @entity209 are an important risk factor for @entity28 @entity565 . Some studies identified that upstream of the transcription start site within the @entity310 gene promoter region-308 polymorphism was associated insulin resistance or @entity209 , while this site was closely related to @entity565 . But no research was performed to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Here, we recruited 248 @entity748 @entity1 , who were separated into @entity565 with Mets/ @entity565 without Mets groups and 226 matched healthy controls from Hebei Province to evaluate the influence of @entity310 @entity15646 polymorphism on @entity209 in @entity748 @entity1 . Single nucleotide polymorphism of @entity310 -308 locus was genotyped using PCR-RFLP. Some biochemical variables were also determined. Our result showed that the genotypic and allelic frequency of @entity40610 did not show significant difference between @entity748 @entity1 and normal controls. However, the frequency of A allele was signi   cantly higher in @entity565 group with Mets (22.36%) than in controls (15.71%) (P = 0.02; OR = 0.647; 95% CI = 0.447-0.936). After analyzing the relationship between biochemical features of @entity1 and genotype of @entity310 @entity15646 , we found levels of LDL @entity165 , @entity310 and insulin, and HOMA-IR were significantly higher in the @entity748 @entity1 carrying the GA and AA genotypes than in the carriers of GG genotype of @entity40610 (P = 0.029, P = 0.022, P = 0.043, respectively). Thus, our data suggested that @entity310 @entity15646 variation was related to metabolic phenotype in @entity565 @entity1 . Furthermore, we first identified @entity310 -308 A allele was the risk factor for @entity748 @entity1 with Mets in Hebei population, China.

title: Genetic polymorphisms of the @entity310 @entity15646 are associated with @entity209 in XXXX @entity1 from Hebei province, China.

answer: @entity748 :: (MESH:D013224,Disease) :: ['asthmatic']