abstract: INTRODUCTION: @entity9 of the face, especially @entity4254 and @entity5587 are indications for surgical interventions after failed medical therapy. In contrast to other forms of @entity10 or atypical @entity158 , where surgical measures are considered to be contraindicated, percutaneous procedures or @entity5663 are able to produce immediate and @entity158 relief. Careful preoperative evaluation is essential to confirm the clinical diagnosis and to rule out other causes as @entity15 or @entity5 afflicting the cranial nerves. The following study will summarize the common surgical techniques and their role considering a mechanism-based therapy as well as document long-term results of these measures. METHODS: Between 1977 and 1997 316 thermo-controlled radiofrequency trigeminal rhizotomies (TK) and 379 @entity5663 ( @entity5663 ) were performed in our hospital to treat @entity4254 ; additional 6 MVDs for @entity5587 and one @entity5663 of the intermediate facial nerve were carried out. Questionnaires were sent out to all @entity1 still living in 1981, 1982, 1992 and 1998. For all other @entity1 , interviews with relatives or the general practitioners were conducted. A retrospective analysis of @entity282 relief was performed using Kaplan-Meier curves at the latest follow-up. Additionally 80 @entity1 underwent careful quantitative sensory testing with Von-Frey-hairs. RESULTS: 225 @entity1 who underwent @entity5663 and 206 with radiofrequency trigeminal rhizotomies were further analyzed. There was a 50% risk for @entity158 recurrence two years after radiofrequency rhizotomy. On the other hand 64% of @entity1 who underwent @entity5663 remained painfree 20 years postoperatively. @entity1 with @entity5663 without @entity51 were painfree significantly longer than @entity1 with @entity86 . DISCUSSION: Etiology and pathogenesis of @entity31465 are far from understood despite several hypotheses. Based on current models there is no explanation for the immediate @entity158 relief especially after @entity5663 . Some authors even discuss surgical @entity130 as the only cause for @entity282 relief.

title: [Neurosurgical therapy of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity4254 :: ('MESH:D014277', 'Disease') :: ['trigeminal neuralgia']

entities_list: @entity5663 :: ('MESH:D003665', 'Disease') :: ['microvascular decompressions', 'MVD', 'microvascular decompression']

entities_list: @entity31465 :: ('MESH:D005156', 'Disease') :: ['facial neuralgias']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['sensory deficit']

entities_list: @entity5587 :: ('MESH:D020435', 'Disease') :: ['glossopharyngeal neuralgia']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative hypesthesia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['facial pain', 'pain', 'longstanding pain']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['Neuralgias']

answer: @entity31465 :: (MESH:D005156,Disease) :: ['facial neuralgias']


abstract: Nineteen adult @entity1 with poor-risk @entity1583 received @entity784 ( @entity784 ) hematopoietic progenitor cell (HPC) transplant from partially mismatched related donors (PMRD). The preparative regimen (FITFA) included fractionated @entity131 , thiotepa, @entity3118 , and @entity1641 (n = 3) or @entity95 (n = 16) anti-thymocyte anti-sera (ATG). GVHD prophylaxis consisted of @entity784 by positive/negative selection using the Isolex 300i system and pre-transplant ATG with no post-transplant immunosuppression. The mean number (+/-s.d.) of transplanted @entity2280 (+) and CD3(+) cells were 8.9 x 10(6)/kg +/-4.3 (range 2.6-19.3) and 1.4 x 10(4)/kg +/-1.2 (range 0.3-4.6) respectively. Seventeen @entity1 evaluable for neutrophil engraftment achieved an ANC >0.5 x 10(9)/l at a median of 12 days (range 9-27), with evidence of full donor chimerism. Thirteen @entity1 died of the following causes: relapse (n = 6), @entity281 (n = 5), @entity401 (n = 1), and unknown causes (n = 1) None of the recipients of @entity95 ATG required therapy for acute or chronic GVHD. Five @entity1 are alive and disease-free at a median time of 303 days post transplant (range 100-660). The FITFA preparative regimen using fractionated @entity131 is well tolerated and is sufficiently immunosuppressive to allow rapid and stable donor origin hematopoietic engraftment without 'mega' doses of @entity2280 (+) cells. Combination of stringent ex vivo @entity784 and pre-transplant ATG is effective GVHD prophylaxis.

title: Rapid hematopoietic engraftment following fractionated XXXX conditioning and transplantation with @entity2280 (+) enriched hematopoietic progenitor cells from partially mismatched related donors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T cell-depleted', 'TCD']

entities_list: @entity3118 :: ('MESH:C024352', 'Chemical') :: ['fludarabine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancy']

entities_list: @entity401 :: ('MESH:D017563', 'Disease') :: ['interstitial pneumonia']

answer: @entity131 :: (MESH:D001930,Disease) :: ['TBI']


abstract: Nineteen adult @entity1 with poor-risk @entity1583 received @entity784 ( @entity784 ) hematopoietic progenitor cell (HPC) transplant from partially mismatched related donors (PMRD). The preparative regimen (FITFA) included fractionated @entity131 , thiotepa, @entity3118 , and @entity1641 (n = 3) or @entity95 (n = 16) anti-thymocyte anti-sera (ATG). GVHD prophylaxis consisted of @entity784 by positive/negative selection using the Isolex 300i system and pre-transplant ATG with no post-transplant immunosuppression. The mean number (+/-s.d.) of transplanted @entity2280 (+) and CD3(+) cells were 8.9 x 10(6)/kg +/-4.3 (range 2.6-19.3) and 1.4 x 10(4)/kg +/-1.2 (range 0.3-4.6) respectively. Seventeen @entity1 evaluable for neutrophil engraftment achieved an ANC >0.5 x 10(9)/l at a median of 12 days (range 9-27), with evidence of full donor chimerism. Thirteen @entity1 died of the following causes: relapse (n = 6), @entity281 (n = 5), @entity401 (n = 1), and unknown causes (n = 1) None of the recipients of @entity95 ATG required therapy for acute or chronic GVHD. Five @entity1 are alive and disease-free at a median time of 303 days post transplant (range 100-660). The FITFA preparative regimen using fractionated @entity131 is well tolerated and is sufficiently immunosuppressive to allow rapid and stable donor origin hematopoietic engraftment without 'mega' doses of @entity2280 (+) cells. Combination of stringent ex vivo @entity784 and pre-transplant ATG is effective GVHD prophylaxis.

title: Rapid hematopoietic engraftment following fractionated @entity131 conditioning and transplantation with XXXX (+) enriched hematopoietic progenitor cells from partially mismatched related donors.

answer: @entity2280 :: (947,Gene) :: ['CD34']


abstract: OBJECTIVE: To evaluate racial differences in limb loss caused by @entity1095 in a diverse, statewide population. DESIGN: Retrospective analysis of a cohort of dysvascular amputees. SETTING: Maryland State Hospital Discharge Data from 1986 to 1997. @entity1 : @entity1 with a procedure code for lower-limb amputation (ICD9-CM code 84.11-.19) were identified. @entity1 with limb loss because of @entity130 , @entity5 , or @entity154 were excluded. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Incidence rates standardized for age, gender, and race; and time trends. RESULTS: There were 27,149 discharges with dysvascular amputations, yielding an average annual rate of 44.3 per 100,000 @entity1 . Incidence rates for dysvascular amputations increased from 41.4 per 100,000 in 1986 to 47.2 per 100,000 in 1997. For all levels of amputation, annual incidence rates among African Americans were considerably higher than those of other @entity1 . African Americans were 2 to 4 times more likely to lose a lower limb than white @entity1 of similar age and gender. CONCLUSIONS: Rising rates of lower-limb amputations in the general population combined with disproportionately higher rates among African Americans are concerning and warrant further investigation into their underlying causes and consequences.

title: Racial differences in the incidence of limb loss secondary to XXXX : a population-based study.

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease']

entities_list: @entity1 :: ('9606', 'Species') :: ['Persons', 'Patients', 'persons', 'PARTICIPANTS']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital anomalies']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

answer: @entity1095 :: (MESH:D016491,Disease) :: ['peripheral vascular disease']


abstract: BACKGROUND: @entity1561 ( @entity1561 ) has been recognized as a cause of @entity409 . Its main risk factor is @entity28 . AIM: To describe the clinical and liver pathological findings in a group of @entity1 who underwent surgery as @entity28 treatment. @entity1 AND METHODS: Sixty eight @entity1 with severe or morbid @entity28 were subjected to surgery as @entity28 treatment. Each @entity1 was evaluated with a complete clinical and laboratory medical assessment. A wedge of liver was excised during surgery. Liver biopsies were analyzed without knowledge of clinical and laboratory findings. The presence of @entity1560 , @entity32 (portal or lobular), @entity82 and @entity82 were recorded in the pathological analysis. Age and body mass index (BMI) were correlated with pathological data. Significance was set at a p value of less than 0.05. RESULTS: Ninety one percent of @entity1 had @entity1560 , 45% @entity32 and 47% @entity82 . One @entity1 had @entity82 (1.4%). There was a statistically significant association between BMI and moderate or severe @entity1560 (p < 0.03). There was also an association between BMI and portal (p = 0.017) and @entity32 (p = 0.034). A BMI over 40 kg/m2 (morbid @entity28 ) was significantly associated with the presence of @entity82 (p = 0.032). Moreover, the presence of moderate or severe @entity1560 was a risk factor for the development of @entity1575 (p = 0.026). CONCLUSIONS: Obesity is a major and independent risk factor for @entity1560 and @entity82 . The degree of @entity1560 in the liver biopsy, is a risk factor for the development of @entity82 .

title: [Obesity: risk factor for XXXX and @entity1575 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['lobular inflammation', 'inflammation']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatohepatitis', 'steatosis']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['chronic liver disease']

entities_list: @entity1561 :: ('MESH:D065626', 'Disease') :: ['Nonalcoholic fatty liver', 'NAFL']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['hepatic fibrosis']

answer: @entity1560 :: (MESH:D005234,Disease) :: ['steatohepatitis']


abstract: BACKGROUND: @entity1561 ( @entity1561 ) has been recognized as a cause of @entity409 . Its main risk factor is @entity28 . AIM: To describe the clinical and liver pathological findings in a group of @entity1 who underwent surgery as @entity28 treatment. @entity1 AND METHODS: Sixty eight @entity1 with severe or morbid @entity28 were subjected to surgery as @entity28 treatment. Each @entity1 was evaluated with a complete clinical and laboratory medical assessment. A wedge of liver was excised during surgery. Liver biopsies were analyzed without knowledge of clinical and laboratory findings. The presence of @entity1560 , @entity32 (portal or lobular), @entity82 and @entity82 were recorded in the pathological analysis. Age and body mass index (BMI) were correlated with pathological data. Significance was set at a p value of less than 0.05. RESULTS: Ninety one percent of @entity1 had @entity1560 , 45% @entity32 and 47% @entity82 . One @entity1 had @entity82 (1.4%). There was a statistically significant association between BMI and moderate or severe @entity1560 (p < 0.03). There was also an association between BMI and portal (p = 0.017) and @entity32 (p = 0.034). A BMI over 40 kg/m2 (morbid @entity28 ) was significantly associated with the presence of @entity82 (p = 0.032). Moreover, the presence of moderate or severe @entity1560 was a risk factor for the development of @entity1575 (p = 0.026). CONCLUSIONS: Obesity is a major and independent risk factor for @entity1560 and @entity82 . The degree of @entity1560 in the liver biopsy, is a risk factor for the development of @entity82 .

title: [Obesity: risk factor for @entity1560 and XXXX ].

answer: @entity1575 :: (MESH:D008103,Disease) :: ['hepatic fibrosis']


abstract: Severe chronic @entity1142 is defined as less than two bowel movements per week, hard stools, non productive urgency and the need of digital maneuvers in more than 25% of bowel evacuations. The best studied causes of chronic severe @entity1142 are slow bowel transit @entity3087 . However, there are mixed forms that cross link with @entity1744 . The main diagnostic tests are anorrectal manometry, bowel evacuation, X-ray studies and anorrectal sphincteromyomectomy, that can be therapeutic. Five percent of @entity1 are surgical candidates. In cases of slow bowel movement, total colectomy with @entity254 has satisfactory results in 80 to 90% of @entity1 . Some @entity1 with pelvic floor dysfunction have an occult rectal prolapse, rectocele or sigmoidocele and obtain benefits with the correction of these conditions. The remaining @entity1 require a training of bowel evacuation, known as biofeedback. We have performed a total colectomy in 10 @entity1 with @entity717 with good functional results in 80%. After 56 months of follow-up, a mean 2.6 bowel movements per day is reported by the @entity1 . Four @entity1 were also operated due to a solitary rectal ulcer and two @entity1 due to a sigmoidocele, with satisfactory results.

title: [Severe chronic XXXX . Is it a problem of surgery?].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3087 :: ('MESH:D059952', 'Disease') :: ['constipation and pelvic floor dysfunction']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['ileorectal anastomosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['slow bowel movements']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable colon syndrome']

answer: @entity1142 :: (MESH:D003248,Disease) :: ['constipation']


abstract: PURPOSE: To analyze the effect of intensified topical @entity479 therapy after Descemet membrane endothelial keratoplasty combined with @entity231 surgery (triple-DMEK) on the incidence of @entity1103 ( @entity1103 ). DESIGN: Single-center comparative clinical study with historical controls. METHODS: Setting: Department of Ophthalmology, University of Cologne, Germany, tertiary hospital, performing 500 corneal transplant surgeries per year. @entity1 : Total of 131 @entity1 (150 eyes) undergoing triple-DMEK surgery. Inclusion Criterion: Triple-DMEK surgery. EXCLUSION CRITERIA: Prior retinal surgery, history of prior @entity1103 . INTERVENTIONS: @entity12356 eye drops 1% 5 times daily for the first week after surgery. After an internal change of therapy regimen: @entity12356 eye drops 1% hourly for the first postoperative week. We compared 75 consecutive eyes before with 75 consecutive eyes after the change of therapy regimen. @entity1 received macular spectral-domain optical coherence tomography (SD OCT) preoperatively, as well as 6  weeks and 3 and 6  months post surgery. MAIN OUTCOME MEASURE: Development of @entity1103 detected by macular SD OCT during 6  months postoperatively. RESULTS: Both groups were comparable regarding baseline age, sex, central corneal thickness, rebubbling rate, and visual acuity. With topical @entity479 therapy 5 times per day during the first postoperative week, we observed 9 cases of subsequent @entity1103 (12%). With hourly topical @entity479 therapy none of the @entity1 developed @entity1103 subsequently (P  = .003). Apart from the topical @entity230 during the first week, medical treatment was identical in both groups. CONCLUSIONS: Early intensified postoperative topical  @entity479 therapy constitutes an effective prophylactic treatment to reduce incidence of @entity1103 after triple-DMEK surgery.

title: Intensified Topical XXXX as Prophylaxis for Macular Edema After Posterior Lamellar Keratoplasty Combined With Cataract Surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity1103 :: ('MESH:D008269', 'Disease') :: ['postoperative cystoid macular edema', 'CME']

entities_list: @entity12356 :: ('MESH:C009935', 'Chemical') :: ['Prednisolone acetate']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity230 :: (MESH:D013256,Chemical) :: ['Steroids']


abstract: BACKGROUND: Ischemic @entity1066 are usually found above the lateral, and @entity3179 at the medial malleoli. Leg @entity1066 occur in at least 25% of @entity3458 ( @entity15838 ) @entity1 in clinic populations, usually in the malleolar region. The function of the large leg veins in most @entity15838 @entity1 is unimpaired. @entity1 AND METHODS: We determined leg @entity1066 location in 41 @entity3458 (SS), and 4 sickle-beta 0 thalassemic @entity1 with longstanding chronic and/or recurrent leg ulceration, and reviewed published reports of @entity6008 in @entity7276 . RESULTS: Of the 57 legs of the 45 @entity15838 @entity1 with only 1 @entity1066 , 42 (74%) were medial and 15 lateral. The difference was significant (p < 0.001). Of @entity1 with only a single @entity1066 , 22 were medial and 4 lateral. Of 15 reported @entity1 with @entity6008 related to @entity8682 or @entity2395 , 20/24 (83%) @entity1066 were medial. CONCLUSIONS: The medial malleoli are the most common site of leg ulceration in @entity15838 and in other chronic @entity5714 . This suggests that @entity3179 may play a role in the leg ulceration associated with chronic @entity5714 .

title: Predilection of XXXX for the medial malleolus.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity7276 :: ('MESH:D013103', 'Disease') :: ['hereditary spherocytosis and thalassemias']

entities_list: @entity2395 :: ('MESH:D013789', 'Disease') :: ['thalassemia']

entities_list: @entity3458 :: ('MESH:D000755', 'Disease') :: ['sickle cell anemia', 'sickle cell disease']

entities_list: @entity3179 :: ('MESH:D014647', 'Disease') :: ['stasis', 'venous stasis ulcers']

entities_list: @entity5714 :: ('MESH:D000743', 'Disease') :: ['hemolytic anemias', 'hemolytic anemia']

entities_list: @entity8682 :: ('MESH:C567159', 'Disease') :: ['spherocytosis']

entities_list: @entity6008 :: ('MESH:D007871', 'Disease') :: ['leg ulcers']

answer: @entity5714 :: (MESH:D000743,Disease) :: ['hemolytic anemia-associated leg ulcers']


abstract: AIMS: @entity1567 ( @entity1567 ) is a @entity5 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity26 concentration is reduced in specific areas of the @entity5 microenvironment, which leads to intratumoral @entity519 . Crosstalk between @entity125 , @entity12943 , @entity7738 and @entity20107 under @entity519 conditions has been implicated in invadopodia formation, @entity5 invasiveness and @entity3 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity1567 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity1567 , 8 cases of @entity5 ( @entity5 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity125 , anti- @entity12943 , anti- @entity7738 and anti- @entity20107 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity1567 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity1567 exhibited increased presence of proteins associated with @entity5 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity5 . This article is protected by copyright. All rights reserved.

title: Role of @entity519 -related proteins in invasion of @entity1567 cells: crosstalk between @entity125 , @entity7738 , XXXX , and @entity20107 .

entities_list: @entity1567 :: ('MESH:D000564', 'Disease') :: ['AME', 'Ameloblastoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'calcifying cystic odontogenic tumors', 'benign tumor', 'CCOTs']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['Oxygen']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia', 'hypoxic']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity12943 :: (8038,Gene) :: ['ADAM-12']


abstract: AIMS: @entity1567 ( @entity1567 ) is a @entity5 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity26 concentration is reduced in specific areas of the @entity5 microenvironment, which leads to intratumoral @entity519 . Crosstalk between @entity125 , @entity12943 , @entity7738 and @entity20107 under @entity519 conditions has been implicated in invadopodia formation, @entity5 invasiveness and @entity3 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity1567 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity1567 , 8 cases of @entity5 ( @entity5 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity125 , anti- @entity12943 , anti- @entity7738 and anti- @entity20107 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity1567 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity1567 exhibited increased presence of proteins associated with @entity5 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity5 . This article is protected by copyright. All rights reserved.

title: Role of @entity519 -related proteins in invasion of @entity1567 cells: crosstalk between XXXX , @entity7738 , @entity12943 , and @entity20107 .

answer: @entity125 :: (4851,Gene) :: ['NOTCH1']


abstract: AIMS: @entity1567 ( @entity1567 ) is a @entity5 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity26 concentration is reduced in specific areas of the @entity5 microenvironment, which leads to intratumoral @entity519 . Crosstalk between @entity125 , @entity12943 , @entity7738 and @entity20107 under @entity519 conditions has been implicated in invadopodia formation, @entity5 invasiveness and @entity3 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity1567 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity1567 , 8 cases of @entity5 ( @entity5 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity125 , anti- @entity12943 , anti- @entity7738 and anti- @entity20107 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity1567 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity1567 exhibited increased presence of proteins associated with @entity5 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity5 . This article is protected by copyright. All rights reserved.

title: Role of @entity519 -related proteins in invasion of XXXX cells: crosstalk between @entity125 , @entity7738 , @entity12943 , and @entity20107 .

answer: @entity1567 :: (MESH:D000564,Disease) :: ['ameloblastoma']


abstract: AIMS: @entity1567 ( @entity1567 ) is a @entity5 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity26 concentration is reduced in specific areas of the @entity5 microenvironment, which leads to intratumoral @entity519 . Crosstalk between @entity125 , @entity12943 , @entity7738 and @entity20107 under @entity519 conditions has been implicated in invadopodia formation, @entity5 invasiveness and @entity3 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity1567 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity1567 , 8 cases of @entity5 ( @entity5 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity125 , anti- @entity12943 , anti- @entity7738 and anti- @entity20107 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity1567 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity1567 exhibited increased presence of proteins associated with @entity5 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity5 . This article is protected by copyright. All rights reserved.

title: Role of XXXX -related proteins in invasion of @entity1567 cells: crosstalk between @entity125 , @entity7738 , @entity12943 , and @entity20107 .

answer: @entity519 :: (MESH:D000860,Disease) :: ['hypoxia']


abstract: AIMS: @entity1567 ( @entity1567 ) is a @entity5 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity26 concentration is reduced in specific areas of the @entity5 microenvironment, which leads to intratumoral @entity519 . Crosstalk between @entity125 , @entity12943 , @entity7738 and @entity20107 under @entity519 conditions has been implicated in invadopodia formation, @entity5 invasiveness and @entity3 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity1567 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity1567 , 8 cases of @entity5 ( @entity5 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity125 , anti- @entity12943 , anti- @entity7738 and anti- @entity20107 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity1567 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity1567 exhibited increased presence of proteins associated with @entity5 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity5 . This article is protected by copyright. All rights reserved.

title: Role of @entity519 -related proteins in invasion of @entity1567 cells: crosstalk between @entity125 , @entity7738 , @entity12943 , and XXXX .

answer: @entity20107 :: (1839,Gene) :: ['HB-EGF']


abstract: AIMS: @entity1567 ( @entity1567 ) is a @entity5 characterized by local invasiveness, high recurrence rates and diverse histological patterns. @entity26 concentration is reduced in specific areas of the @entity5 microenvironment, which leads to intratumoral @entity519 . Crosstalk between @entity125 , @entity12943 , @entity7738 and @entity20107 under @entity519 conditions has been implicated in invadopodia formation, @entity5 invasiveness and @entity3 development. The objective of this study was to analyze the expression of these proteins to further elucidate mechanisms underlying @entity1567 invasiveness. METHODS AND RESULTS: A total of 20 cases of @entity1567 , 8 cases of @entity5 ( @entity5 ) and 10 samples of dental follicle were used to investigate the expression of these proteins by immunohistochemistry using the primary antibodies anti- @entity125 , anti- @entity12943 , anti- @entity7738 and anti- @entity20107 . Immunostaining results were expressed as the percentage of stained area in images acquired in an AxioScope microscope equipped with an AxioCamHRc camera and a 40* objective. The results showed that immunoexpression of all proteins were higher in the @entity1567 samples than in the CCOT and dental follicle samples (p<0.05). CONCLUSIONS: @entity1567 exhibited increased presence of proteins associated with @entity5 invasiveness, which indicates a possible role of these proteins in the biological behavior of this @entity5 . This article is protected by copyright. All rights reserved.

title: Role of @entity519 -related proteins in invasion of @entity1567 cells: crosstalk between @entity125 , XXXX , @entity12943 , and @entity20107 .

answer: @entity7738 :: (3091,Gene) :: ['HIF-1a']


abstract: UNASSIGNED: The DNA repair pathway mismatch repair (MMR) is responsible for the recognition and correction of DNA biosynthetic errors caused by inaccurate @entity4334 incorporation during replication. Faulty MMR leads to failure to address the mispairs or insertion deletion loops (IDLs) left behind by the replicative polymerases and results in increased mutation load at the genome. The realization that defective MMR leads to a hypermutation phenotype and increased risk of tumorigenesis highlights the relevance of this pathway for @entity1 disease. The association of MMR defects with increased risk of @entity5 development was first observed in @entity14 @entity1 that carried inactivating germline mutations in MMR genes and the disease was named as @entity14 ( @entity14 ). Currently, a growing list of @entity5 is found to be MMR defective and @entity14 has been renamed @entity4309 ( @entity4309 ) partly to include the associated risk of developing @entity694 . In addition, a number of non-hereditary, mostly epigenetic, alterations of MMR genes have been described in @entity5 . Besides conferring a strong @entity5 predisposition, genetic or epigenetic inactivation of MMR genes also renders cells resistant to some chemotherapeutic agents. Therefore, diagnosis of @entity5527 has important implications for the management of the @entity1 , the surveillance of their relatives in the case of @entity4309 and for the choice of treatment. Some of the alterations found in MMR genes have already been well defined and their pathogenicity assessed. Despite this substantial wealth of knowledge, the effects of a large number of alterations remain uncharacterized (variants of uncertain significance, VUSs). The advent of personalized genomics is likely to increase the list of VUSs found in MMR genes and anticipates the need of diagnostic tools for rapid assessment of their pathogenicity. This review describes current tools and future strategies for addressing the relevance of MMR gene alterations in @entity1 disease.

title: Approaches to diagnose DNA mismatch repair gene defects in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome', 'LS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['sporadic tumors', 'cancers', 'cancer']

entities_list: @entity5527 :: ('MESH:C536928', 'Disease') :: ['MMR deficiency']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['HNPCC', 'hereditary non-polyposis colorectal cancer', 'colorectal cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['extra-colonic cancers']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND: It is unknown, whether cardiac troponin (cTn) I or @entity10020 is the preferred biomarker in the detection of exercise-induced @entity741 . METHODS: We investigated @entity1 with suspected @entity741 referred for exercise or pharmacological rest/stress myocardial perfusion single-photon emission computed tomography (SPECT) to directly compare the diagnostic accuracy of high-sensitivity @entity6949 (hs- @entity6949 ) and hs- @entity10020 . Diagnostic performance was analyzed separately according to stress modality. Hs- @entity6949 and hs- @entity10020 were measured before, immediately after, as well as 2h and 4h after maximal exercise in a blinded fashion. Further, all clinical information available to the treating cardiologist was used to quantify the clinical judgment regarding the presence of @entity741 using a visual analog scale twice: once prior and once after stress-testing. The presence of stress-induced @entity741 was adjudicated using SPECT combined with coronary angiography findings. RESULT: A total of 403 consecutive @entity1 were enrolled in our study, of which 229 underwent exercise stress and 174 @entity1 pharmacological stress. Exercise-stress-induced @entity741 was detected in 90 @entity1 (39.3% of 229). Levels of hs- @entity6949 and hs- @entity10020 were both significantly higher at all time-points examined in @entity1 with exercise-induced @entity741 as compared to @entity1 without @entity741 (all p<0.001). Correlation of hs- @entity6949 and hs- @entity10020 was high in direct comparison of time-points (Spearman's rho all >= 0.7). The AUCs for baseline/peak/2h/4h for hs- @entity6949 and hs- @entity10020 were 0.71/0.71/0.72/0.69 vs. 0.74/0.73/0.71/0.72, respectively (all p=ns for hs- @entity6949 versus hs- @entity10020 ). In @entity1 undergoing pharmacological stress, the AUCs for baseline/peak/2h/4h for hs- @entity6949 and hs- @entity10020 were 0.66/0.66/0.68/0.67 and 0.61/0.62/0.64/0.59, respectively (all p=ns for hs- @entity6949 versus hs- @entity10020 ). Also the combinations including clinical judgment or changes during serial sampling were similar for hs- @entity6949 and hs- @entity10020 (all p=ns). CONCLUSIONS: Hs- @entity6949 and hs- @entity10020 provide comparable diagnostic information regarding exercise-induced @entity741 . Overall, their diagnostic accuracy seems moderate. UNIQUE IDENTIFIER: NCT01838148.

title: Direct comparison of cardiac troponin I and cardiac troponin T in the detection of exercise-induced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

answer: @entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']


abstract: AIMS: @entity6 ( @entity6 ) is considered to be one of the important risk factors for @entity299 . Frank @entity6 is usually preceded by long term abnormality in @entity413 homeostasis which is called pre- @entity6 . The hypothesis that @entity6 @entity1 have greater risk and worse prognosis of @entity583 ( @entity583 ) than pre- @entity6 is controversial. Considering that India has been declared as a @entity6 capital of the world, the study aimed to assess the load of pre @entity6 , @entity6 and non- @entity6 landing in @entity583 . MATERIALS AND METHODS: The study consisted of through physiological and biochemical evaluation of 200 @entity1 of newly diagnosed @entity583 and evaluating the load of non- @entity6 , pre- @entity6 and @entity6 among them. RESULT: It was found that the total non- @entity6 population (normoglycaemic and pre- @entity6 ) formed the bulk of @entity583 @entity1 (69%) in our study. The degree of biochemical alterations seen among the three groups suggests that abnormal @entity413 homeostasis is not the sole determinant of the severity of @entity583 . The study data also suggests that glycaemic status, which poses a risk for @entity583 , differs in male and female individuals. Males even with normal @entity413 level are at increased risk to develop MI. CONCLUSION: The study concludes that both males and females with their blood @entity413 in pre- @entity6 range are seen to be vulnerable to develop @entity583 . Thus all individuals irrespective of their glycaemic status around the age of forty should be screened and individuals with fasting sugar in pre- @entity6 range should take extra precaution in terms of healthy diet, life style and regular check up.

title: Glycaemic status in @entity1 of XXXX : A detailed analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic', 'diabetes', 'Diabetes mellitus', 'DM']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac diseases']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['Acute Myocardial Infarction', 'AMI', 'myocardial infarction']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']


abstract: AIMS: @entity6 ( @entity6 ) is considered to be one of the important risk factors for @entity299 . Frank @entity6 is usually preceded by long term abnormality in @entity413 homeostasis which is called pre- @entity6 . The hypothesis that @entity6 @entity1 have greater risk and worse prognosis of @entity583 ( @entity583 ) than pre- @entity6 is controversial. Considering that India has been declared as a @entity6 capital of the world, the study aimed to assess the load of pre @entity6 , @entity6 and non- @entity6 landing in @entity583 . MATERIALS AND METHODS: The study consisted of through physiological and biochemical evaluation of 200 @entity1 of newly diagnosed @entity583 and evaluating the load of non- @entity6 , pre- @entity6 and @entity6 among them. RESULT: It was found that the total non- @entity6 population (normoglycaemic and pre- @entity6 ) formed the bulk of @entity583 @entity1 (69%) in our study. The degree of biochemical alterations seen among the three groups suggests that abnormal @entity413 homeostasis is not the sole determinant of the severity of @entity583 . The study data also suggests that glycaemic status, which poses a risk for @entity583 , differs in male and female individuals. Males even with normal @entity413 level are at increased risk to develop MI. CONCLUSION: The study concludes that both males and females with their blood @entity413 in pre- @entity6 range are seen to be vulnerable to develop @entity583 . Thus all individuals irrespective of their glycaemic status around the age of forty should be screened and individuals with fasting sugar in pre- @entity6 range should take extra precaution in terms of healthy diet, life style and regular check up.

title: Glycaemic status in XXXX of @entity583 : A detailed analysis.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: CONTEXT: New therapies have evolved from our improved understanding of the biology of @entity3458 ( @entity3458 ) and the availability of a useful transgenic animal model. Several therapeutic options are available that interrupt the sickling process at various key pathways. @entity842 (NO)is a critical factor in the pathophysiology of @entity3458 and is a promising antisickling agent with vasodilation properties. NO regulates blood vessel tone, endothelial adhesion, and the severity of ischaemia-reperfusion injury and @entity417 in @entity3458 . Although NO is difficult to administer, its precursor, @entity8561 , is an oral supplement. STARTING POINT: J R Romero and colleagues recently demonstrated in sickle @entity19 that oral @entity369 supplementation induced NO production and reduced red-cell density by inhibiting the Gardos channel, which modulates cell hydration and polymerisation of haemoglobin S (Blood 2002; 99:1103-08). Haemoglobinopathies can be cured by stem-cell transplantation. This therapy is now accepted treatment in symptomatic @entity1 . However, most @entity1 lack a genotypically identical family donor. G La Nasa and colleagues demonstrated unrelated-donor stem-cell transplantation may give similar results to related-donor stem-cell transplantation when extended phenotypic matching is used (Blood 2002; 99: 4350-56). This pilot study offers the possibility of cure to @entity1 without a family donor. WHERE NEXT: Although potential opportunities to prevent morbidity in @entity3458 through new therapies are exciting, most @entity1 do not have access to standard multidisciplinary specialty care. @entity1 require both.

title: New therapies in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity19 :: ('10090', 'Species') :: ['transgenic mice']

entities_list: @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCD', 'sickle cell disease']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity3458 :: (MESH:D000755,Disease) :: ['sickle cell disease']


abstract: Percutaneous stenting has become the procedure of choice for treatment of obstructive @entity8 . @entity256 , however, continues to be in the range of 15-25% of treated vessels. In this study, clinical and angiographic predictors of @entity256 were assessed. Of 132 vessels included, fifty-eight were followed for @entity256 using duplex Doppler (n=15), conventional angiogram (n=33) or multislice computed tomography (CT) angiogram (n=10). Fifteen vessels (26%) met the criteria for @entity256 (lesion > or =50% by conventional or CT angiography or >60% by Doppler) at a follow-up range of 2-20 months (5% <2 months; 68% 3-12 months; 27% 13-20 months). Cox Regression analyses were performed for selected variables. A p-value <0.05 was considered statistically significant. History of smoking [odds ratio (OR), 6.6:1; p=0.005] and time to evaluate for @entity256 were independent predictors of the occurrence of @entity256 . Also, a high @entity256 rate (40%) was seen in vessels < or =4 mm in diameter (n=20) in contrast to larger vessels (n=38) >4 mm (18.4%). Although statistical significance was not reached (possibly because of the small sample size), clinically this is a significant finding. A significant drop in systolic (-15.6 mmHg) and diastolic (-6.2 mmHg) blood pressures was seen following @entity8 stenting with no significant change in the total number of antihypertensives used (2.4 versus 2.5 for pre- and post-renal stenting, respectively). CONCLUSION: @entity256 occurred in 26% of successfully stented RAs. History of smoking, time to evaluate for @entity256 and small vessels (< or =4 mm) were predictors of its occurrence. Clinically, a significant drop in blood pressure was seen with @entity8 stenting without a change in the total number of antihypertensives on follow-up.

title: Clinical and angiographic predictors of XXXX stenting.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['atherosclerotic renal artery (RA) disease', 'RA']

entities_list: @entity256 :: ('MESH:D023903', 'Disease') :: ['Restenosis', 'restenosis']

answer: @entity8 :: (MESH:D007674,Disease) :: ['restenosis following renal artery']


abstract: A @entity1 given intravesical BCG immunotherapy developed @entity1907 . After resection of a superficial @entity150 , the @entity1 was given weekly intravesical BCG infusions. After the 4th session, the @entity1 developed @entity221 (40 degrees C), shivers, dry cough, profuse sweating, and @entity353 . Initially, the chest x-ray was normal. The @entity1 was given isoniazid (5 mg/kg) in a single-drug regimen. Rapid degradation of the general status led to a new chest x-ray, 10 days later, which demonstrated a @entity751 . High-resolution thoracic CT confirmed the diagnosis of @entity1907 . A three-drug antituberculosis regimen associated with @entity288 was followed by restoration of the general status. Antituberculosis therapy was continued for 9 months. The 9-month thoracic CT revealed a smaller number of micronodules in the @entity358 . This case illustrates the discussion concerning the appropriate treatment for @entity1 who develop a @entity281 after intravesical BCG-therapy.

title: [ XXXX following intravesical BCG-therapy].

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['systemic infection']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder tumor']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary parenchyma']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['reticulonodular syndrome']

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['miliary pulmonary tuberculosis']

answer: @entity1907 :: (MESH:D014397,Disease) :: ['Miliary pulmonary tuberculosis']


abstract: AIM: To assess the level of evidence for subjective and objective parameters in clinical orofacial examination and determine if predictors for @entity1348 ( @entity1348 ) involvement in @entity4932 ( @entity4932 ) @entity1 exist in the current literature. METHOD: A comprehensive systematic electronic search strategy was performed in all major medical databases in June 2015. Studies were selected independently by two reviewers in accordance with a prespecified protocol and a risk of bias assessment for all included studies. Subjective examination outcome measures assessed were @entity158 , decreased @entity1348 function, and @entity1348 sounds. The objective outcome measures assessed were maximal incisor opening, mandibular asymmetric opening, condylar translation, protrusion, @entity158 on palpation, @entity7439 , and micro- or retrognathism. RESULTS: The electronic database search identified 345 unique citations. After application of our strict, predefined inclusion and exclusion criteria, 21 articles were included and data extracted. The study heterogeneity did not allow for meta-analyses. No singular outcome measure can be suggested as a predictor of @entity1348 involvement in @entity4932 , as sensitivity and/or specificity is too low compared to contrast-enhanced magnetic resonance imaging. CONCLUSION: The current low level of evidence and study heterogeneity do not allow us to conclude on singular clinical outcome measures. To increase study comparability, we call for a standardized terminology and evidence-based guidelines for clinical orofacial examination parameters in @entity4932 @entity1 .

title: Clinical predictors of temporomandibular joint arthritis in XXXX : A systematic literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4932 :: ('MESH:D001171', 'Disease') :: ['JIA', 'juvenile idiopathic arthritis']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['myofascial pain', 'pain']

entities_list: @entity7439 :: ('MESH:D005146', 'Disease') :: ['facial asymmetry']

entities_list: @entity1348 :: ('MESH:D013706', 'Disease') :: ['TMJ', 'temporomandibular joint']

answer: @entity4932 :: (MESH:D001171,Disease) :: ['juvenile idiopathic arthritis']


abstract: @entity1 with @entity412 levels over 1,000 mg/dl are at high risk of developing acute @entity788 . This study aimed to determine the effectiveness of plasma exchange (PE) in reducing @entity412 levels during an acute attack of @entity788 ( @entity788 ). A total of 17 @entity6308 @entity1 with the complication of acute @entity788 received one course of PE treatment for one or two consecutive sessions. The respective mean removal rates during a single PE for @entity412 , @entity165 , amylase, and lipase were 66.3, 62.1, 70.0, and 84.8%, respectively. An additional one exchange increased the removal rate to 83.3, 66.2, 85.5, and 87.0%, respectively. For the two-sessions of treatment, the removal rates were higher for @entity412 (P=0.0015) and amylase with a borderline statistical significance (P=0.0641). Better @entity412 clearance correlated well with lower levels of transmembrane pressure ( @entity1597 ) at 90 minutes after PE (r2=0.5782, P=0.0010) and shorter plasmapheresis duration (r2=0.2241, P=0.0427). Thirteen of seventeen @entity1 (76.5%) recovered completely, eight @entity1 in a single-session, and five in two-sessions. Two @entity1 developed @entity6177 , necessitating surgical drainage and two @entity1 died due to both @entity326 and @entity881 . No significant predictor of clinical outcome was identified. In summary, PE treatment is an effective method to clear lipids and enzymes from plasma in a single session for most @entity788 @entity1 . A greater extraction of @entity412 would result in a reduced @entity1597 and a shorter duration of PE treatment.

title: Plasmapheresis for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['hyperlipidemic pancreatitis', 'pancreatitis', 'HLP']

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock']

entities_list: @entity6177 :: ('MESH:D018784', 'Disease') :: ['intra-abdominal abscess']

entities_list: @entity6308 :: ('MESH:D064250', 'Disease') :: ['hypertriglyceridemic']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multi-organ failure']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity788 :: (MESH:D010190,Disease) :: ['hyperlipidemic pancreatitis']


abstract: INTRODUCTION: Approximately 60 000 prosthetic valves are implanted annually in the USA. The risk of prosthesis dysfunction ranges from 0.1% to 4% per year. Prosthesis @entity340 is usually caused by a @entity715 obstructing the prosthetic discs. However, 10% of prosthetic valves are dysfunctional due to @entity2070 formation, and 12% of prostheses are damaged by both fibrinous and @entity715 components. The authors present two @entity1 with dysfunctional aortic prostheses who were referred for cardiac surgery. Different surgical solutions were used in the treatment of each case. CASE STUDY 1: The first @entity1 was a 71-year-old @entity1 whose medical history included arterial @entity101 , stable @entity453 , @entity6 , @entity1030 ( @entity1030 ), and @entity1007 ; she had previously undergone left-sided mastectomy and radiotherapy. The @entity1 was admitted to the Cardiac Surgery Department due to @entity2333 . Transthoracic echocardiography revealed @entity3885 and a severe reduction in the mobility of the second. The mean transvalvular gradient was very high. During the operation, @entity2070 covering the discs' surface was found. A biological aortic prosthesis was reimplanted without complications. CASE STUDY 2: The second @entity1 was an 87-year-old @entity1 with arterial @entity101 , persistent @entity955 , and @entity1030 , whose past medical history included @entity2275 and @entity385 . As in the case of the first @entity1 , she was admitted due to @entity340 . Preoperative transthoracic echocardiography revealed an obstruction of the posterior prosthetic disc and significant @entity337 . Transesophageal echocardiography and fluoroscopy confirmed the prosthetic dysfunction. During the operation, a @entity715 growing around a minor @entity2070 was found. The @entity715 and @entity2070 were removed, and normal functionality of the prosthetic valve was restored. CONCLUSIONS: Precise and modern diagnostic methods facilitated selection of the treatment method. However, the intraoperative view also seems to be crucial in individualizing the surgical approach.

title: Artificial aortic valve dysfunction due to XXXX and @entity715 - different methods of cardiac surgical management.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['complete obstruction of one disc']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic prosthesis dysfunction']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'thrombotic']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valve dysfunction', 'valvular prosthesis dysfunction']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

entities_list: @entity2275 :: ('MESH:D013276', 'Disease') :: ['gastric ulcer disease']

answer: @entity2070 :: (MESH:C537858,Disease) :: ['pannus']


abstract: INTRODUCTION: Approximately 60 000 prosthetic valves are implanted annually in the USA. The risk of prosthesis dysfunction ranges from 0.1% to 4% per year. Prosthesis @entity340 is usually caused by a @entity715 obstructing the prosthetic discs. However, 10% of prosthetic valves are dysfunctional due to @entity2070 formation, and 12% of prostheses are damaged by both fibrinous and @entity715 components. The authors present two @entity1 with dysfunctional aortic prostheses who were referred for cardiac surgery. Different surgical solutions were used in the treatment of each case. CASE STUDY 1: The first @entity1 was a 71-year-old @entity1 whose medical history included arterial @entity101 , stable @entity453 , @entity6 , @entity1030 ( @entity1030 ), and @entity1007 ; she had previously undergone left-sided mastectomy and radiotherapy. The @entity1 was admitted to the Cardiac Surgery Department due to @entity2333 . Transthoracic echocardiography revealed @entity3885 and a severe reduction in the mobility of the second. The mean transvalvular gradient was very high. During the operation, @entity2070 covering the discs' surface was found. A biological aortic prosthesis was reimplanted without complications. CASE STUDY 2: The second @entity1 was an 87-year-old @entity1 with arterial @entity101 , persistent @entity955 , and @entity1030 , whose past medical history included @entity2275 and @entity385 . As in the case of the first @entity1 , she was admitted due to @entity340 . Preoperative transthoracic echocardiography revealed an obstruction of the posterior prosthetic disc and significant @entity337 . Transesophageal echocardiography and fluoroscopy confirmed the prosthetic dysfunction. During the operation, a @entity715 growing around a minor @entity2070 was found. The @entity715 and @entity2070 were removed, and normal functionality of the prosthetic valve was restored. CONCLUSIONS: Precise and modern diagnostic methods facilitated selection of the treatment method. However, the intraoperative view also seems to be crucial in individualizing the surgical approach.

title: Artificial aortic valve dysfunction due to @entity2070 and XXXX - different methods of cardiac surgical management.

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombus']


abstract: BACKGROUND: Japan has four seasons and many chances of low atmospheric pressure or approaches of typhoon, therefore it has been empirically known that the fluctuation of weather induces @entity2704 in @entity1 . Generally, its mechanism has been interpreted as follows: physical loading, attributed by atmospheric pressure to @entity1 bodies, compresses or dilates @entity1 blood vessels, which leads to abnormality in blood flow and induces @entity2704 . We report our examination of the stage in which @entity2704 tends to be induced focusing on the variation of atmospheric pressure. FINDINGS: Subjects were 34 @entity1 with @entity2704 , who were treated in our hospital. The @entity1 included 31 females and three males, whose mean age was 32      6.7. 22 @entity1 had @entity2795 and 12 @entity1 had @entity5330 . All of @entity1 with @entity2704 maintained a @entity10 diary to record atmospheric pressures when they developed a @entity2704 . The standard atmospheric pressure was defined as 1013  hPa, and with this value as the criterion, we investigated slight fluctuations in the atmospheric pressure when they developed a @entity2704 . It was found that the atmospheric pressure when the @entity1 developed a @entity2704 was within 1003-1007  hPa in the approach of low atmospheric pressure and that the @entity1 developed a @entity2704 when the atmospheric pressure decreased by 6-10  hPa, slightly less than the standard atmospheric pressure. CONCLUSION: Small decreases of 6-10  hPa relative to the standard atmospheric pressure of 1013  hPa induced @entity2704 attacks most frequently in @entity1 with @entity2704 .

title: Examination of fluctuations in atmospheric pressure related to XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'people']

entities_list: @entity2795 :: ('MESH:D020325', 'Disease') :: ['migraine with aura']

entities_list: @entity5330 :: ('MESH:D020326', 'Disease') :: ['migraine without aura']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity2704 :: (MESH:D008881,Disease) :: ['migraine']


abstract: OBJECTIVE: To evaluate the sensitivity and specificity of immunohistochemical (IHC) staining of DNA mismatch repair (MMR) protein for the screening of @entity124 ( @entity124 ) @entity14 ( @entity14 ). METHODS: A total of 255 @entity14 cases were studied, including 140 cases of routine paraffin-embedded tissue samples and 115 cases constructed on tissue microarray. Expressions of 4 MMR proteins including MHL1, @entity4311 , @entity4638 and @entity14437 were investigated by IHC. Negative protein expression was defined as complete absence of nuclear staining within @entity5 cells in the presence of positively labeled internal non-neoplastic cells. Focal staining was defined as the presence of staining in < 5% of the @entity5 cells. CRCs showing negative staining for any MMR proteins were interpreted as MMR deficient @entity5 . PCR-genescan @entity124 analysis was performed in each case by a five marker panel including Bat26, Bat25, NR-21, NR-24 and MONO-27. RESULTS: Among the 140 CRCs with routine formalin-fixed paraffin embedded tissue sections, concordance rate between IHC and PCR-genescan was 98.6% (138/140), the sensitivity and specificity of IHC in detecting @entity5 were 94.9% (37/39) and 100.0% (101/101), respectively. The 2 disconcordant cases showed focal staining in at least one of the MMR proteins but were confirmed to be @entity124 CRCs by PCR-genescan assay. On tissue microarray, 91.3% (105/115) of the cases had informative results. The concordance rate between IHC and PCR-genescan was 100.0% (105/105). Both the specificity and sensitivity of IHC in detecting @entity5 on available tissue microarray samples were 100.0%. Ten cases were inclusive due to the presence of negative stains of MMR proteins in both the @entity5 and internal control cells. CONCLUSIONS: Detection of 4 MMR proteins expression by IHC is reliable for identifying @entity124 CRCs and is recommended for routine practice. @entity5 with focal MMR protein staining are highly suspected for the presence of @entity124 and PCR-genescan based @entity124 analysis should be performed to confirm.

title: [Value of detection of DNA mismatch repair proteins deficiency by immunohistochemistry in predicting XXXX microsatellite status].

entities_list: @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI-H', 'MSI', 'microsatellite instability']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'MSI tumors', 'tumors']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: BACKGROUND: Red cell distribution width (RDW) is associated with morbidity and mortality in chronic @entity299 . The aim of the present study was to investigate the role of RDW as a predictor of adverse outcome in @entity1 with @entity2998 . MATERIALS AND METHODS: We prospectively studied 1065 of 1286 consecutive @entity1 with neurological asymptomatic @entity543 as assessed by duplex Doppler sonography. The study endpoints were all-cause mortality and cardiovascular mortality respectively. RESULTS: During a median follow-up time of 6.2 years (interquartile range 5.9 to 6.6), corresponding to 5,551 overall @entity1 -years, 275 @entity1 (25.8%) died. Of these, 182 @entity1 (66.2%) died due to cardiovascular causes. RDW was significantly associated with adverse outcome. In a continuous multivariate Cox regression analysis, the adjusted hazard ratio for each percent increase in RDW was 1.39 (95% CI 1.27-1.53; p<0.001) for all-cause and 1.43 (95% CI 1.28-1.60; p<0.001) for cardiovascular mortality, respectively. Kaplan-Meier estimates showed a gradual relationship between increasing quartiles of RDW and @entity204 (log rank p<0.001). Adjusted hazard ratios for all-cause @entity204 ranged from 0.89 to 1.94 for the highest versus the lowest quartile (p<0.001 for trend) and for @entity65 from 1.08 to 2.34 for the highest versus the lowest quartile (p<0.001 for trend), respectively. CONCLUSIONS: RDW was significantly and independently associated with all-cause and @entity65 in @entity1 with asymptomatic @entity2998 . This article is protected by copyright. All rights reserved.

title: Red cell distribution width and mortality in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'person']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular death']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease']

entities_list: @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid artery stenosis']

answer: @entity2998 :: (MESH:D002340,Disease) :: ['carotid atherosclerosis']


abstract: OBJECTIVES: To summarize the characteristics of backfill in @entity1 with @entity1691 (SpA) and @entity1 with @entity615 ( @entity615 ) and healthy controls, and to assess the value of backfill in diagnosing axial SpA. METHODS: Three readers blinded recorded backfill seen on T1SE MRI scans from 647  subjects: 297  @entity1 with @entity1691 ( @entity1691 ), 126  @entity1 with non-radiographic axial SpA (nr-axSpA), 147  @entity1 with @entity615 , and 77  healthy controls. The SPARCC SIJ Structural Score (SSS) method was used to assess backfill. The changes of backfill were evaluated by the follow-up MRI scans from 157  @entity1 . We summarized the characteristics of backfill and calculated its sensitivity and specificity for diagnosing axial SpA. RESULTS: Backfill was recorded in 78.8% @entity1691 @entity1 , 11.1% nr-axSpA @entity1 , 1.8% @entity1 with @entity615 , and no healthy control. Backfill affected more frequently at ilium bone, lower half of sacroiliac joints in axial SpA (both P<0.05). The SSS score of backfill was much higher in axial SpA than in @entity1 with @entity615 (both P<0.01) and it did not correlate with demographics and BASDAI, BASFI, and CRP (all P>0.05). The score of backfill only positively correlated with symptom duration in @entity1691 (r=0.251, P<0.01) and in nr-axSpA (r=0.743, P<0.01) @entity1 . Only 8.9% @entity1 had the change of backfill in an average follow-up time of 1.09  years. Backfill had high specificity (0.98) and moderate sensitivity (0.59) for diagnosing axial SpA. CONCLUSIONS: We summarized the characteristics of backfill and found that backfill is a specific sign of axial SpA seen on T1SE MRI.

title: Backfill is a specific sign of XXXX seen on MRI.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['NSBP', 'non-specific back pain']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['axial spondyloarthritis', 'ankylosing spondylitis', 'AS']

answer: @entity1691 :: (MESH:D013167,Disease) :: ['axial spondyloarthritis']


abstract: Eleven pairs of symmetrically conjoined twins underwent surgical separation at the Queen Sirikit National Institute of @entity1 Health. Six were omphalopagus, 4 were thoracopagus and 1 was pygopagus. Eight were female and 3 were male. Three pairs were separated on emergency or semi-emergency bases, and the remaining 8 pairs were separated electively at an older age. Of the 3 pairs who had early emergency separations, one pair, whose combined birth weight was only 2,500 g, underwent emergency separation at the age of 44 days after the death of one twin. The second twin also expired one hour after the separation. In the remaining 2 pairs, early separation was done because of the deterioration of one twin due to @entity299 . In both cases, the @entity1 with @entity299 expired but the others survived the separation satisfactorily. In one pair of @entity7411 , one twin had cyanotic @entity299 . They were electively separated at the age of 2 years and 9 months. The twin with @entity299 expired 2 hours after surgery, but the other survived the separation satisfactorily. In the remaining 7 pairs who underwent elective separations, both twins of each pair survived the separation satisfactorily. However, one twin expired unexpectedly 10 days after the separation.

title: XXXX : surgical separation in 11 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'infants']

entities_list: @entity7411 :: ('MESH:D014428', 'Disease') :: ['thoracopagus conjoined twins']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['complex cardiac anomalies', 'cardiac anomalies']

answer: @entity7411 :: (MESH:D014428,Disease) :: ['Conjoined twins']


abstract: UNASSIGNED: The aim of this study is to investigate the epidemiology, diagnosis, treatment and risk factors of @entity1582 @entity1 with @entity3 ( @entity3 ) in China. We analyzed @entity1582 ( @entity1582 ) @entity1 receiving chemotherapy in a prospective multicenter study. Basic characteristics, the diagnosis, and treatment of @entity3 were recorded. A total of 395 @entity1582 @entity1 were enrolled, who received a total of 443 chemotherapy courses. Among them, 17 IFDs were diagnosed during one chemotherapy course. Fourteen of these were possible @entity3 and 3 were probable @entity3 . Ten of the 14 @entity1 with possible @entity3 had @entity358 . Thirty eight (8.6  %) patients received antifungal prophylaxis, and 47.4  % of them were administered with @entity2380 . @entity1 who had a history of @entity3 or underwent a combined therapy with two antibiotics for over 7  days and with a history of @entity3028 or ductus venosus insertion were more likely to be treated with antifungal prophylaxis. All of first-line antifungal therapies were monotherapy. Eleven (84.6  %) cases were treated with @entity8201 . The median time of initial antifungal therapy was 8  days. The general condition of two @entity1 with probable @entity3 and 10 @entity1 (90.9  %) with possible @entity3 improved, while 1 @entity1 with possible @entity3 died. Multivariate analysis revealed that history of @entity3 is an independent risk factor of @entity3 . The present multicenter study suggests that the incidence of @entity3 per chemotherapy courses in @entity1582 @entity1 is 3.8  % and most @entity1 are labelled as having possible @entity3 . @entity2380 is the most common antifungal agent for prophylaxis and @entity18111 for therapeutic treatment. Previous @entity3 is a probable independent risk factor of @entity3 in @entity1582 @entity1 receiving chemotherapy.

title: Epidemiology and treatment of invasive fungal diseases in @entity1 with XXXX : findings from a multicenter prospective study from China.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity2380 :: ('MESH:D015725', 'Chemical') :: ['Fluconazole', 'fluconazole']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung infection']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive fungi disease', 'IFD']

entities_list: @entity18111 :: ('MESH:D065819', 'Chemical') :: ['voriconazole']

entities_list: @entity3028 :: ('MESH:D000380', 'Disease') :: ['granulocytopenia']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['multiple myeloma']


abstract: UNASSIGNED: The aim of this study is to investigate the epidemiology, diagnosis, treatment and risk factors of @entity1582 @entity1 with @entity3 ( @entity3 ) in China. We analyzed @entity1582 ( @entity1582 ) @entity1 receiving chemotherapy in a prospective multicenter study. Basic characteristics, the diagnosis, and treatment of @entity3 were recorded. A total of 395 @entity1582 @entity1 were enrolled, who received a total of 443 chemotherapy courses. Among them, 17 IFDs were diagnosed during one chemotherapy course. Fourteen of these were possible @entity3 and 3 were probable @entity3 . Ten of the 14 @entity1 with possible @entity3 had @entity358 . Thirty eight (8.6  %) patients received antifungal prophylaxis, and 47.4  % of them were administered with @entity2380 . @entity1 who had a history of @entity3 or underwent a combined therapy with two antibiotics for over 7  days and with a history of @entity3028 or ductus venosus insertion were more likely to be treated with antifungal prophylaxis. All of first-line antifungal therapies were monotherapy. Eleven (84.6  %) cases were treated with @entity8201 . The median time of initial antifungal therapy was 8  days. The general condition of two @entity1 with probable @entity3 and 10 @entity1 (90.9  %) with possible @entity3 improved, while 1 @entity1 with possible @entity3 died. Multivariate analysis revealed that history of @entity3 is an independent risk factor of @entity3 . The present multicenter study suggests that the incidence of @entity3 per chemotherapy courses in @entity1582 @entity1 is 3.8  % and most @entity1 are labelled as having possible @entity3 . @entity2380 is the most common antifungal agent for prophylaxis and @entity18111 for therapeutic treatment. Previous @entity3 is a probable independent risk factor of @entity3 in @entity1582 @entity1 receiving chemotherapy.

title: Epidemiology and treatment of invasive fungal diseases in XXXX with @entity1582 : findings from a multicenter prospective study from China.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: @entity2969 ( @entity2969 ) represent the most common @entity5 group in the age group of 20 to 40-years old @entity1 . The potentially curable effect of cytotoxic therapy in @entity2969 is mediated mainly by the induction of apoptosis. Autophagy has been discussed as an alternative mechanism of cell death but also of treatment resistance in various types of @entity5 . However, in @entity2969 the expression and role of core autophagy-associated factors is hitherto unknown. We designed the study in order to evaluate the potential role of autophagy-associated factors in the development and progression of @entity5 . Eighty-four @entity1 were assessed for autophagy ( @entity5266 , @entity10407 ) and apoptosis (cleaved caspase  3) markers using immunohistochemistry (IHC) on tissue micro- arrays. In addition, western blot analyses of frozen tissue of @entity4797 and @entity4797 were performed. Our findings show that @entity5266 was significantly upregulated in @entity4797 as compared to @entity4797 but not to normal testicular tissue. No significant difference of @entity10407 expression was detected between neoplastic and normal tissue or between @entity4797 and @entity4797 . @entity5266 and @entity10407 showed distinct loco  -regional expression patterns in normal and neoplastic @entity1 testicular tissues. In contrast to the autophagic markers, apoptosis rate was significantly higher in @entity5 as compared to normal testicular tissue, but not between different @entity2969 subtypes. The present study, for the first time, examined the expression of central autophagy proteins @entity5266 and @entity10407 in @entity5 . Our findings imply that in general apoptosis but not autophagy induction differs between normal and neoplastic testis tissue.

title: Autophagy-associated proteins @entity5266 and @entity10407 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'men']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['testicular cancers', 'testicular cancer', 'malignant tumor', 'testicular tumors', 'tumors']

entities_list: @entity2969 :: ('MESH:C563236', 'Disease') :: ['Testicular germ cell tumors', 'TGCT']

entities_list: @entity4797 :: ('MESH:D018239', 'Disease') :: ['non-seminoma', 'seminoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['testicular cancer']


abstract: UNASSIGNED: @entity2969 ( @entity2969 ) represent the most common @entity5 group in the age group of 20 to 40-years old @entity1 . The potentially curable effect of cytotoxic therapy in @entity2969 is mediated mainly by the induction of apoptosis. Autophagy has been discussed as an alternative mechanism of cell death but also of treatment resistance in various types of @entity5 . However, in @entity2969 the expression and role of core autophagy-associated factors is hitherto unknown. We designed the study in order to evaluate the potential role of autophagy-associated factors in the development and progression of @entity5 . Eighty-four @entity1 were assessed for autophagy ( @entity5266 , @entity10407 ) and apoptosis (cleaved caspase  3) markers using immunohistochemistry (IHC) on tissue micro- arrays. In addition, western blot analyses of frozen tissue of @entity4797 and @entity4797 were performed. Our findings show that @entity5266 was significantly upregulated in @entity4797 as compared to @entity4797 but not to normal testicular tissue. No significant difference of @entity10407 expression was detected between neoplastic and normal tissue or between @entity4797 and @entity4797 . @entity5266 and @entity10407 showed distinct loco  -regional expression patterns in normal and neoplastic @entity1 testicular tissues. In contrast to the autophagic markers, apoptosis rate was significantly higher in @entity5 as compared to normal testicular tissue, but not between different @entity2969 subtypes. The present study, for the first time, examined the expression of central autophagy proteins @entity5266 and @entity10407 in @entity5 . Our findings imply that in general apoptosis but not autophagy induction differs between normal and neoplastic testis tissue.

title: Autophagy-associated proteins XXXX and @entity10407 in @entity5 .

answer: @entity5266 :: (9531,Gene) :: ['BAG3']


abstract: UNASSIGNED: @entity2969 ( @entity2969 ) represent the most common @entity5 group in the age group of 20 to 40-years old @entity1 . The potentially curable effect of cytotoxic therapy in @entity2969 is mediated mainly by the induction of apoptosis. Autophagy has been discussed as an alternative mechanism of cell death but also of treatment resistance in various types of @entity5 . However, in @entity2969 the expression and role of core autophagy-associated factors is hitherto unknown. We designed the study in order to evaluate the potential role of autophagy-associated factors in the development and progression of @entity5 . Eighty-four @entity1 were assessed for autophagy ( @entity5266 , @entity10407 ) and apoptosis (cleaved caspase  3) markers using immunohistochemistry (IHC) on tissue micro- arrays. In addition, western blot analyses of frozen tissue of @entity4797 and @entity4797 were performed. Our findings show that @entity5266 was significantly upregulated in @entity4797 as compared to @entity4797 but not to normal testicular tissue. No significant difference of @entity10407 expression was detected between neoplastic and normal tissue or between @entity4797 and @entity4797 . @entity5266 and @entity10407 showed distinct loco  -regional expression patterns in normal and neoplastic @entity1 testicular tissues. In contrast to the autophagic markers, apoptosis rate was significantly higher in @entity5 as compared to normal testicular tissue, but not between different @entity2969 subtypes. The present study, for the first time, examined the expression of central autophagy proteins @entity5266 and @entity10407 in @entity5 . Our findings imply that in general apoptosis but not autophagy induction differs between normal and neoplastic testis tissue.

title: Autophagy-associated proteins @entity5266 and XXXX in @entity5 .

answer: @entity10407 :: (23636,Gene) :: ['p62']


abstract: PURPOSE: The goal of our study was to determine the benefits of screening by non-mydriatic retinal camera in the @entity15164 region and to present the results of this screening. @entity1 AND METHODS: We report a prospective study of 430  @entity6 @entity1 , or 860  eyes, compiled between December  2012 and June  2013 in the Dokkarat health center, "integrated referral center for management of @entity6 and @entity101 " in the region of @entity15164 . All @entity1 underwent an examination by non-mydriatic fundus camera, obtaining two digital images per eye. The photos are taken by a nurse and a general practitioner. Interpretation of the images was performed in the ophthalmology department of the Hassan  II University Medical Center of @entity15164 . RESULTS: A total of 430  @entity1 were screened (78.4% female, 21.6% male). The mean age was 54.7  years (range, 10-80  years). The average duration of @entity6 was 7.7  years (  5.9). Most @entity1 had @entity164  2 @entity6 (94%). Insulin therapy was found in 35.3%. The mean HbA1c (obtained from 421  @entity1 ) was 8.21%. 38,8% of @entity1 had never consulted an ophthalmologist before. The fundus photographs were not interpretable for at least one eye in 75  cases (17.4%). Among the interpretable images, the prevalence of @entity6 ( @entity6 ) was 44.6%. @entity6 was present in at least one eye in 2.5% and @entity6 in 32  cases (9%). After screening, 69% of @entity1 with @entity6 were seen by the ophthalmologist. CONCLUSION: These data confirm the benefits of screening by non-mydriatic retinal camera, because it helps reintegrate @entity1 into the healthcare system and thus provides a real benefit in terms of public health and prevention of complications.

title: [Screening for @entity6 by non-mydriatic retinal camera in the region of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'Proliferative diabetic retinopathy', 'diabetes', 'DR', 'diabetic maculopathy', 'diabetic retinopathy']

answer: @entity15164 :: (389549,Gene) :: ['Fez']


abstract: PURPOSE: The goal of our study was to determine the benefits of screening by non-mydriatic retinal camera in the @entity15164 region and to present the results of this screening. @entity1 AND METHODS: We report a prospective study of 430  @entity6 @entity1 , or 860  eyes, compiled between December  2012 and June  2013 in the Dokkarat health center, "integrated referral center for management of @entity6 and @entity101 " in the region of @entity15164 . All @entity1 underwent an examination by non-mydriatic fundus camera, obtaining two digital images per eye. The photos are taken by a nurse and a general practitioner. Interpretation of the images was performed in the ophthalmology department of the Hassan  II University Medical Center of @entity15164 . RESULTS: A total of 430  @entity1 were screened (78.4% female, 21.6% male). The mean age was 54.7  years (range, 10-80  years). The average duration of @entity6 was 7.7  years (  5.9). Most @entity1 had @entity164  2 @entity6 (94%). Insulin therapy was found in 35.3%. The mean HbA1c (obtained from 421  @entity1 ) was 8.21%. 38,8% of @entity1 had never consulted an ophthalmologist before. The fundus photographs were not interpretable for at least one eye in 75  cases (17.4%). Among the interpretable images, the prevalence of @entity6 ( @entity6 ) was 44.6%. @entity6 was present in at least one eye in 2.5% and @entity6 in 32  cases (9%). After screening, 69% of @entity1 with @entity6 were seen by the ophthalmologist. CONCLUSION: These data confirm the benefits of screening by non-mydriatic retinal camera, because it helps reintegrate @entity1 into the healthcare system and thus provides a real benefit in terms of public health and prevention of complications.

title: [Screening for XXXX by non-mydriatic retinal camera in the region of @entity15164 ].

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic retinopathy']


abstract: OBJECTIVE: To report the incidence and analyze the factor predisposing to @entity65 after orthotopic liver transplantation (OLTx). METHODS: A retrospective study was made for the @entity1 who develop of all cases in which @entity1 presented with @entity65 after OLTx from April 1993 to December 2001 in the First Affiliated Hospital of Sun Yat-sen University, Guangzhou. RESULTS: Eighty-nine liver transplants were performed in 88 @entity1 . @entity65 developed in 65 (73%) @entity1 . Among these 65 complications, 6 were @entity63 , 9 were @entity712 , 59 were @entity101 and 5 were @entity120 . portoperative mortality rate related to @entity65 was 12.4% (11/89). Except for the preexisting @entity453 , the unbalance between coagulant and anticoagulant function in @entity1 after OLTx may play a role in @entity63 after OLTx. @entity712 was correlated with massive intraoperative blood transplantation (chi2=5.714, P<0.05). CONCLUSION: @entity65 are common after OLTx. They are severe and highly related to mortality. The unbalance between coagulant and anticoagulant function in @entity1 after OLTx resulting in the @entity715 in coronary artery may be the cause of @entity63 . Massive intraoperative blood transplantation may be responsible for @entity712 .

title: [The clinical management of XXXX after orthotopic liver transplantation].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure', 'heart failure']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['myocardiac ischemia']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular complications', 'cardiovascular complications', 'cardiovascular complication']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular complications']


abstract: @entity1 @entity70835 ( @entity70835 ) is the autoantigen recognized by anti-liver cytosol type 1 (LC1) autoantibodies in @entity775 ( @entity775 ) @entity1 . In @entity35 , this octameric protein is localized on the Golgi apparatus and binds brain microtubules (MTs) and vimentin. Subcellular localization of @entity1 @entity70835 and its implication in the pathogenesis of @entity775 are unknown. Localization of the @entity1 @entity70835 in @entity1 hepatocytes was done using indirect immunofluorescence and subcellular fractionations followed by in vitro binding techniques. The @entity70835 antigen at two distinct locations in hepatocytes, free in the cytosol and associated with the Golgi membranes are recognized by anti-liver cytosol type 1 autoantibodies. The @entity1 @entity70835 binds reversibly to the Golgi membranes and this complex formation is increased by anti-liver cytosol type 1 autoantibodies. Finally, @entity1 @entity70835 does not interact with liver-specific cytoskeleton proteins. Anti-liver cytosol type 1 autoantibodies are directed against the mature high molecular form of @entity1 @entity70835 . Therefore, the subcellular location of the protein may influence the production of autoantibodies and their role in the pathogenesis of @entity775 . This antigen-driven response does not appear to be facilitated or enhanced by a possible interaction between @entity1 @entity70835 and hepatocyte cytoskeleton proteins.

title: Characterization of the antigenicity of the XXXX in @entity775 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'Human']

entities_list: @entity775 :: ('MESH:D019693', 'Disease') :: ['type 2 autoimmune hepatitis', 'AIH', 'autoimmune hepatitis']

entities_list: @entity70835 :: ('10841', 'Gene') :: ['hFTCD', 'formiminotransferase-cyclodeaminase']

answer: @entity70835 :: (10841,Gene) :: ['formiminotransferase-cyclodeaminase']


abstract: @entity1 @entity70835 ( @entity70835 ) is the autoantigen recognized by anti-liver cytosol type 1 (LC1) autoantibodies in @entity775 ( @entity775 ) @entity1 . In @entity35 , this octameric protein is localized on the Golgi apparatus and binds brain microtubules (MTs) and vimentin. Subcellular localization of @entity1 @entity70835 and its implication in the pathogenesis of @entity775 are unknown. Localization of the @entity1 @entity70835 in @entity1 hepatocytes was done using indirect immunofluorescence and subcellular fractionations followed by in vitro binding techniques. The @entity70835 antigen at two distinct locations in hepatocytes, free in the cytosol and associated with the Golgi membranes are recognized by anti-liver cytosol type 1 autoantibodies. The @entity1 @entity70835 binds reversibly to the Golgi membranes and this complex formation is increased by anti-liver cytosol type 1 autoantibodies. Finally, @entity1 @entity70835 does not interact with liver-specific cytoskeleton proteins. Anti-liver cytosol type 1 autoantibodies are directed against the mature high molecular form of @entity1 @entity70835 . Therefore, the subcellular location of the protein may influence the production of autoantibodies and their role in the pathogenesis of @entity775 . This antigen-driven response does not appear to be facilitated or enhanced by a possible interaction between @entity1 @entity70835 and hepatocyte cytoskeleton proteins.

title: Characterization of the antigenicity of the @entity70835 in XXXX .

answer: @entity775 :: (MESH:D019693,Disease) :: ['type 2 autoimmune hepatitis']


abstract: PURPOSE: To investigate the feasibility of raster scanned heavy charged particle therapy in the treatment of @entity263 (PCa,) with special regard to the influence of internal organ motion on the dose distribution. METHODS AND MATERIALS: The CT data of 8 @entity1 with PCa who underwent three-dimensional conformal radiotherapy (RT) were chosen. In addition to the routine treatment planning scan, three to five additional positioning control CT scans were performed. The organs at risk and the target volumes were defined on all CT scans. Primary and boost @entity505 ion plans were calculated to deliver 66 Gy to the clinical target volume/planning target volume, with an additional 10 Gy to the gross @entity5 volume (GTV). To estimate the influence of internal organ motion on plan quality, the dose was recalculated on the basis of the control CT scans. The comparative analysis was based on the dose-volume histogram-derived physical parameters. RESULTS: The average 90% target coverage was 99.1% for the GTV. The maximal dose to the rectum was 71.8 Gy. The average rectal mean dose was 19 Gy. The volume of the rectum receiving 70 and 68 Gy was 0.1 and 0.3 cm3. The average difference in the 90% coverage for the GTV on control CT cubes was 3.6%. The maximal rectal dose increased to 76.2 Gy. The deviation in the mean rectal dose was <1 Gy on average. The rectal volume receiving 70 and 68 Gy increased to 2.5 and 3.3 cm3. CONCLUSION: The investigation demonstrated the feasibility of raster scanned @entity505 ions for PCa RT. Excellent coverage of the target volume and optimal sparing of the rectum were acquired. The combination of photon intensity-modulated RT and a @entity505 ion boost to the GTV is the most rational solution for the gain of clinical experience in heavy ion RT for PCa @entity1 .

title: Evaluation of therapeutic potential of heavy ion therapy for @entity1 with locally advanced XXXX .

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: PURPOSE: To investigate the feasibility of raster scanned heavy charged particle therapy in the treatment of @entity263 (PCa,) with special regard to the influence of internal organ motion on the dose distribution. METHODS AND MATERIALS: The CT data of 8 @entity1 with PCa who underwent three-dimensional conformal radiotherapy (RT) were chosen. In addition to the routine treatment planning scan, three to five additional positioning control CT scans were performed. The organs at risk and the target volumes were defined on all CT scans. Primary and boost @entity505 ion plans were calculated to deliver 66 Gy to the clinical target volume/planning target volume, with an additional 10 Gy to the gross @entity5 volume (GTV). To estimate the influence of internal organ motion on plan quality, the dose was recalculated on the basis of the control CT scans. The comparative analysis was based on the dose-volume histogram-derived physical parameters. RESULTS: The average 90% target coverage was 99.1% for the GTV. The maximal dose to the rectum was 71.8 Gy. The average rectal mean dose was 19 Gy. The volume of the rectum receiving 70 and 68 Gy was 0.1 and 0.3 cm3. The average difference in the 90% coverage for the GTV on control CT cubes was 3.6%. The maximal rectal dose increased to 76.2 Gy. The deviation in the mean rectal dose was <1 Gy on average. The rectal volume receiving 70 and 68 Gy increased to 2.5 and 3.3 cm3. CONCLUSION: The investigation demonstrated the feasibility of raster scanned @entity505 ions for PCa RT. Excellent coverage of the target volume and optimal sparing of the rectum were acquired. The combination of photon intensity-modulated RT and a @entity505 ion boost to the GTV is the most rational solution for the gain of clinical experience in heavy ion RT for PCa @entity1 .

title: Evaluation of therapeutic potential of heavy ion therapy for XXXX with locally advanced @entity263 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Three obstetric groups matched for parity, age, color, marital and socioeconomic status, were compared for the psychosocial antecedents to abortion or term delivery and sequelae that did exist. One group had induced abortion by suction curettage, the second had induced abortion by saline injection, and the third had term delivery. 373 @entity1 were interviewed during pregnancy; 211 were included in follow-up after an average of 16 months for abortion @entity1 and 13 months for the term delivery group. The 373 @entity1 received a structured 90-minute interview about family relationships, consort relationships, living arrangements, income, education, religious behavior, sexual behavior, contraceptive knowledge and use, pregnancy history and desired family size. The Srole @entity5547 scale and the Rosenberg Self-Esteem scale were also used. At the followup interview, similar questions were asked and the two attitude scales were again presented. The MMPI (Minnesota Multiphasic Personality Inventory) and the SCL (Symptom Check List) were also used. 12% of the 211 follow-up scored higher than 70 on the MMPI for @entity162 and psychopathy scales; these @entity1 were evenly divided among the three groups. SCL scales showed the three groups of @entity1 to be similar after abortion or birth, with the only statistically significant difference being the suction curettage group, which had fewer complaints after abortion than either of the other two groups. There was no difference on the @entity5547 or self-esteem scale between pre- or post-procedure for any of the groups. The data suggest neither great harm nor great benefit with regard to these variables due to either @entity5852 or term birth. Early abortion by suction curettage was possibly more therapeutic than carrying a pregnancy to term. There were striking improvements with regard to contraceptive use after the procedure. 71% of each group used effective contraception for more than 12 months after abortion or birth: a 20% increase for the term birth group, a 13% increase for the suction curettage group, and a 26% increase for the saline abortion group. Among abortion @entity1 , those found to have low self-esteem, low contraceptive knowledge, high alienation, and who delayed in seeking abortion were related to long recovery times, a high MMPI psychopathology scale, and a number of unpleasant body symptoms post-abortion. These @entity1 could be predicted with accuracy 32% better than chance alone.

title: Psychiatric sequelae to term birth and induced XXXX : a longitudinal study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity5852 :: ('MESH:D000031', 'Disease') :: ['early or late abortion']

entities_list: @entity5547 :: ('MESH:D000849', 'Disease') :: ['anomia', 'Anomia']

answer: @entity5852 :: (MESH:D000031,Disease) :: ['early and late abortion']


abstract: The majority of @entity204 among @entity1 after renal transplantation is attributed to @entity65 ( @entity65 ). @entity121 ( @entity121 ) of the common carotid artery is related to @entity453 . One of the major causes of @entity204 due to @entity65 is @entity1187 , which is precipitated by @entity301 and subsequent @entity715 . The aim of the study was to evaluate associations between some fibrinolytic factors: antigens of @entity3479 ( @entity3479 ), plasminogen activator inhibitor ( @entity2289 ), and @entity557 ( @entity557 ), and @entity121 in a population of renal transplant recipients. The study was performed on 33 Caucasian, clinically stable kidney transplant recipients (11 @entity1 , mean age 43 years, range 26 to 62 years). All the @entity1 were on triple immunosuppressive regimen ( @entity205 , @entity229 , and @entity500 ) and had stable graft function (serum @entity1011 1.7 +/- 0.7 mg/dL). The mean time since transplantation was 49.9 months (range 4.1 to 131.8 months). In univariate analysis @entity121 correlated significantly with age (r =.5; P =.001), pulse pressure (PP) (r =.4; P =.05), time on dialysis prior to transplantation (r =.6; P =.001), @entity2002 (r =.4; P =.02), and @entity3479 (r =.6; P =.001). Multiple regression analysis showed that @entity3479 antigen concentration (P =.001), @entity2002 (P <.05), and time on dialysis prior to transplantation (P <.05) were positive independent predictors of @entity121 . These data support the concept of the coincidence of disturbances in fibrinolysis and arterial remodelling in @entity1 after kidney transplantation. On the other hand the study shows that the duration of dialysis therapy before transplantation is detrimental to the arterial vasculature.

title: Plasma XXXX , @entity2002 , and time on dialysis prior to transplantation are related to carotid intima media thickness in renal transplant recipients.

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary plaque rupture']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity557 :: ('1361', 'Gene') :: ['TAFI', 'thrombin-activatable fibrinolysis inhibitor']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary and cerebrovascular arterial disease']

entities_list: @entity3479 :: ('5327', 'Gene') :: ['t-PA', 'tissue-type plasminogen activator']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'Intima media thickness']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

answer: @entity3479 :: (5327,Gene) :: ['tissue-type plasminogen activator']