abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity4562 combined with @entity900 and @entity136 for advanced @entity1149 . MATERIALS AND METHODS: A total of 57 @entity1 with advanced @entity1149 ( @entity1149 ), who received @entity902 -based chemotherapy regimens for more than 1 cycle, were treated with @entity4562 combined with @entity900 and @entity136 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity1 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity1 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity294 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity3 was foudn in 31.6% (18/57). CONCLUSIONS: @entity4562 combined with @entity900 andgemcitabine, is effective for @entity1 with IIIb~IV @entity1149 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with @entity4562 Combined with XXXX and @entity136 for Advanced @entity1149 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4562 :: ('MESH:C419708', 'Chemical') :: ['gefitinib', 'Gefitinib']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['Cisplatin']


abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity4562 combined with @entity900 and @entity136 for advanced @entity1149 . MATERIALS AND METHODS: A total of 57 @entity1 with advanced @entity1149 ( @entity1149 ), who received @entity902 -based chemotherapy regimens for more than 1 cycle, were treated with @entity4562 combined with @entity900 and @entity136 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity1 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity1 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity294 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity3 was foudn in 31.6% (18/57). CONCLUSIONS: @entity4562 combined with @entity900 andgemcitabine, is effective for @entity1 with IIIb~IV @entity1149 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with @entity4562 Combined with @entity900 and @entity136 for Advanced XXXX .

answer: @entity1149 :: (MESH:D002289,Disease) :: ['Non- small Cell Lung Cancer']


abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity4562 combined with @entity900 and @entity136 for advanced @entity1149 . MATERIALS AND METHODS: A total of 57 @entity1 with advanced @entity1149 ( @entity1149 ), who received @entity902 -based chemotherapy regimens for more than 1 cycle, were treated with @entity4562 combined with @entity900 and @entity136 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity1 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity1 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity294 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity3 was foudn in 31.6% (18/57). CONCLUSIONS: @entity4562 combined with @entity900 andgemcitabine, is effective for @entity1 with IIIb~IV @entity1149 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with XXXX Combined with @entity900 and @entity136 for Advanced @entity1149 .

answer: @entity4562 :: (MESH:C419708,Chemical) :: ['Gefitinib']


abstract: OBJECTIVE: To analyze the efficacy and survival associated factors of @entity4562 combined with @entity900 and @entity136 for advanced @entity1149 . MATERIALS AND METHODS: A total of 57 @entity1 with advanced @entity1149 ( @entity1149 ), who received @entity902 -based chemotherapy regimens for more than 1 cycle, were treated with @entity4562 combined with @entity900 and @entity136 until disease progression. Efficacy, survival time and adverse reactions were observed. The Kaplan-Meier method was adopted for analysis of survival and Cox regression for associated influencing factors. RESULTS: The @entity1 were followed up until October 31, 2013, and the median follow-up time was 19 months. Of 57 @entity1 , there were 4 (7.0%) with complete remission (CR), 8 (14.0%) with partial remission, 31 (54.4%) with stable disease, and 14 (24.6%) with disease progression. The remission rate was 21.1% and the disease control rate was 75.4%. The median progression-free survival (PFS) time and the median overall survival time were 10 months and 15.2 months. The one-year, two-year and three- year survival rates were 47.4%, 23.3% and 10.0%. Gender and pathological types were the independent risk factors influencing PFS time (P=0.028, P=0.009). Tumor pathological type and early efficacy were independent factors for the prognosis (P=0.018, P=0.000). Adverse reactions were mostly rashes of I~II degree and @entity294 and slightly increasing level of aminopherase. The skin adverse event incidence of III degree or above was 1.8% (1/57) and brain @entity3 was foudn in 31.6% (18/57). CONCLUSIONS: @entity4562 combined with @entity900 andgemcitabine, is effective for @entity1 with IIIb~IV @entity1149 who received multiple cycles of chemotherapy.

title: Efficacy and Survival-associated Factors with @entity4562 Combined with @entity900 and XXXX for Advanced @entity1149 .

answer: @entity136 :: (MESH:C056507,Chemical) :: ['Gemcitabine']


abstract: BACKGROUND: Esophagogastroduodenoscopy (EGD) is the standard technique for diagnosis of @entity1 presenting with @entity344 . Some reports have shown high prevalence of @entity418 in the northern part of Afghanistan. The aim of this study was to investigate epidemiological profile of @entity418 among @entity1 in this region. MATERIALS AND METHODS: We identified 364 consecutive @entity1 that received EGD examinations to examine upper gastrointestinal tract at the endoscopy unit of Balkh regional Hospital from March 2012 to March 2013. The case subjects included both in- @entity1 and out- @entity1 aged 16 years or more. We evaluated the results retrospectively. RESULTS: The cases consisted of 184 (51%) males and 180 (49%) females. The mean age was 47.3  17.8 and the age range 17-88 years. Ninety two cases had @entity418 , out of which 58 (63.0%) were male. The mean age at time of diagnosis was 57.8  13.2 years. Uzbek-Turkmen @entity1 were more common among @entity1 with @entity418 (52.2%). @entity1282 was the most frequent symptom among @entity1 with @entity418 at the time of presentation, seen in 77 (84.8%) of cases. CONCLUSIONS: Our results showed high incidence of @entity418 in the northern part of Afghanistan, especially in the Uzbek-Turkmen ethnic group.

title: Prevalence of XXXX in the northern part of afghanistan.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'peoples']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['upper gastrointestinal symptoms']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['Dysphagia']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

answer: @entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']


abstract: OBJECTIVES: We aimed to investigate the feasibility and safety of @entity285 septal ablation (ASA) via transradial approach using a sheathless guiding catheter. BACKGROUND: Although ASA is conventionally performed via the femoral artery, there is a potential risk of @entity548 and other @entity455 . The transradial approach may be associated with a lower rate of such complications. A sheathless guiding catheter, with an advanced hydrophilic coating along its full length, could reduce radial @entity432 and @entity2473 . METHODS: We enrolled 14 consecutive @entity1 with @entity1121 treated with ASA via the radial access at Sendai Kousei Hospital from December 2012 to May 2014. Left radial access was used for the sheathless guiding catheter, while right radial access was used for monitoring left ventricular pressure with a 4 Fr diagnostic catheter. A temporary pacemaker was inserted via the right jugular vein. RESULTS: Procedural success rate was 93% (13/14 @entity1 ). The left ventricular outflow tract pressure gradient at rest was reduced from a median of 128 mm Hg (interquartile range, 49-147 mm Hg) at baseline to a median of 16 mm Hg (interquartile range, 13-26 mm Hg) at 30-day follow-up (P=.01). The New York Heart Association functional class improved from a median of II (II-III) at baseline to a median of I (I-I) at 30-day follow-up (P=.01). There were no cases of access-site complication, including radial @entity432 and @entity2473 . CONCLUSIONS: The transradial approach using a sheathless guiding catheter was feasible and safe for ASA.

title: Transradial Approach of XXXX Septal Ablation Using a Sheathless Guiding Catheter: A Feasibility Study.

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular complications']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['artery occlusion']

entities_list: @entity1121 :: ('MESH:D002312', 'Disease') :: ['hypertrophic obstructive cardiomyopathy']

answer: @entity285 :: (D000431,Chemical) :: ['Alcohol']


abstract: BACKGROUND:: The optimal treatment for hyperacute @entity64 attributable to cervical internal carotid artery (C-ICA) occlusion remains controversial. OBJECTIVE:: This study sought to evaluate clinical outcomes and prognostic factors after @entity2998 ( @entity2998 ) in @entity1 with hyperacute @entity64 within 6 hours of onset. METHODS:: Forty-seven @entity1 with hyperacute @entity64 attributable to @entity432 underwent emergent @entity2998 . Forty-two @entity1 (89.4%) had @entity432 ( @entity432 ). When @entity1 showed remnant M1 or proximal M2 occlusions after @entity2998 , intracranial recanalization therapy was performed by using pharmacologic thrombolysis and mechanical thrombectomy with a Solitaire stent. Clinical and radiologic data were compared between @entity1 with favorable (modified Rankin scale, 0-2) and unfavorable outcomes. Binary logistic regression analysis was used to find independent prognostic factors. RESULTS:: Emergent @entity2998 was successful in all but 1 @entity1 . Seven (16.7%) of 42 @entity1 with @entity432 did not need further treatment, because thrombolysis in @entity2806 >= 2b was achieved immediately after @entity2998 . Of the 35 @entity1 who underwent intracranial recanalization therapy for remnant @entity432 , thrombolysis in @entity2806 >= 2b was achieved in 71.4% (25 of 35). Twenty-six @entity1 (55.3%) had favorable outcomes, and mortality was 6.4% at 3 months. Time from symptom onset to carotid recanalization was inversely and independently associated with a favorable outcome for all @entity1 and for those with @entity432 (P < .05). CONCLUSION:: In our @entity1 group, emergent @entity2998 for hyperacute @entity64 caused by @entity432 seemed to be effective and safe. Time to carotid recanalization was inversely and independently associated with a favorable outcome. ABBREVIATIONS:: ACST, acute carotid stent thrombosisCAS, carotid artery stentingCI, confidence intervalC-ICA, cervical internal carotid arteryCR, carotid recanalizationICH, intracranial hemorrhageIR, intracranial recanalizationIV, intravenousMCA, middle cerebral arterymRS, modified Rankin scaleNIHSS, National Institutes of Health @entity64 ScalertPA, recombinant tissue plasminogen activatorTICI, thrombolysis in cerebral ischemiaTIO, @entity432 .

title: Outcomes and Prognostic Factors After Emergent Carotid Artery Stenting for Hyperacute XXXX Within 6 Hours of Symptom Onset.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid artery stenting', 'CAS']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['atherosclerotic C-ICA occlusion', 'TIO', 'tandem intracranial artery occlusion']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: UNASSIGNED: Endometriosis is a disease characterized by the growth of endometrial tissue outside the uterus and is associated with chronic @entity2371 . Peritoneal fluid (PF) of @entity1 with @entity46 is a dynamic milieu and is rich in inflammatory markers, @entity158 -inducing prostaglandins prostaglandin E2 and prostaglandin F2a, and lipid peroxides; and the endometriotic tissue is innervated with nociceptors. Our clinical study showed that the abundance of oxidatively modified lipoproteins in the PF of @entity1 with @entity46 and the ability of antioxidant supplementation to alleviate @entity158 . We hypothesized that oxidatively modified lipoproteins present in the PF are the major source of nociceptive molecules that play a key role in @entity158 . In this study, PF obtained from @entity1 with @entity46 or control @entity1 were used for (1) the detection of lipoprotein-derived oxidation-sensitive @entity158 molecules, (2) the ability of such molecules to induce nociception, and (3) the ability of antioxidants to suppress this nociception. LC-MS/MS showed the generation of eicosanoids by oxidized-lipoproteins to be similar to that seen in the PF. Oxidatively modified lipoproteins induced @entity2332 (intracerebroventricular) in CD-1 @entity19 and nociception in the Hargreaves paw withdrawal latency assay in Sprague-Dawley rats. Antioxidants, vitamin E and N-acetylcysteine, and the nonsteroidal anti-inflammatory drug indomethacin suppressed the @entity158 -inducing ability of oxidatively modified lipoproteins. Treatment of @entity1 endometrial cells with oxidatively modified lipoproteins or PF from @entity1 with @entity46 showed upregulation of similar genes belonging to opioid and inflammatory pathways. Our finding that oxidatively modified lipoproteins can induce nociception has a broader impact not only on the treatment of @entity158 but also on other diseases associated with @entity1118 .

title: Oxidation-sensitive nociception involved in XXXX .

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['endometriosis-associated pain', 'pain']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

answer: @entity158 :: (MESH:D010146,Disease) :: ['endometriosis-associated pain']


abstract: UNASSIGNED: Several studies have shown that psychological factors such as learning, expectation, and emotions can affect pharmacological treatment and shape both favorable and adverse effects of drugs. This study investigated whether nocebo information provided during administration of an analgesic cream could reverse topical @entity1337 to @entity1931 . Furthermore, we tested whether nocebo effects were mediated by negative emotional activation. A total of 142 healthy volunteers (73 @entity1 ) were randomized into 6 groups. A topical analgesic cream (Emla) was administered together with suggestions of @entity1337 in 1 group, whereas another group received Emla with suggestions of @entity1931 . Two other groups received a placebo cream together with the same information as the groups receiving Emla. A fifth group received Emla with no specific information about the effect, and the sixth group received no treatment but the same @entity158 induction as the other groups. @entity158 stimulation (48  C) was administered during a pretest and 2 posttests. @entity158 was continuously recorded during stimulation, and measures of subjective stress and blood pressure were obtained before the pretest, after the application of cream, and after the posttests. The results revealed that @entity158 was significantly lower in the group receiving Emla with positive information and highest in the groups receiving suggestions of @entity1931 , regardless of whether Emla or the placebo was administered. Mediation analyses showed that stress and blood pressure mediated @entity1931 after nocebo suggestions. These results suggest that nocebo information can reverse topical @entity1337 and that emotional factors can explain a significant proportion of variance in nocebo @entity1931 .

title: Opposite effects of the same drug: reversal of topical XXXX by nocebo information.

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'Heat pain', 'pain']

answer: @entity1337 :: (MESH:D000699,Disease) :: ['analgesia']


abstract: The incidence of traumatic @entity438 are rare. In review of literature, only six cases of @entity439 in posterior fossa are reported. The @entity1 , 15-year-old @entity1 , was admitted on Dec. 18th, 1979, presented with unconsciousness after a traffic accident. She was developed @entity1662 and @entity1269 with @entity4265 and @entity1415 . Skull film showed an @entity174 and a laminal fracture of the atlas. CT scan demonstrated traumatic subarachnoid, @entity548 and @entity5745 . After accident, she regained consciousness with conservative therapy, but she deteriorated on the 10th hospitalized day. On the 17th day, lumbar puncture and CT scan revealed recurrent subarachnoid and @entity548 . The @entity439 on the lateral medullary segment of the right posterior @entity5487 was obtained by cerebral angiogram on the 35th day. The configuration and size of the @entity439 was easily demonstrated by CT scans and cerebral angigrams. On the 43rd day, the clipping of the common trunk of the right posterior @entity5487 was employed. Her postoperative course was uneventful and she was discharged on the 97th day in @entity558 . This @entity439 was suggested to be induced by severe @entity542 with clinical ad operative findings. With the introduction of CT scan, CT scan is more available diagnostic modality than cerebral angiography in the follow up study with severe @entity542 . And in the absence of pathological CT scan findings, suspicion of traumatic @entity73 such as @entity439 should be paid. As the conservative management of traumatic @entity438 carries high mortality rate up to 30-50%, the prompt diagnosis and direct surgical intervention are recommended.

title: [Traumatic XXXX (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patient']

entities_list: @entity5745 :: ('MESH:D011007', 'Disease') :: ['pneumocephalus']

entities_list: @entity558 :: ('MESH:C536528', 'Disease') :: ['good condition']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['occipital linear fracture']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intraventricular hemorrhage']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['left hemiparesis']

entities_list: @entity1415 :: ('MESH:D004844', 'Disease') :: ['nasal bleeding']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cerebrovascular impairments']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injuries', 'head injury']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['saccular aneurysm', 'traumatic aneurysms', 'aneurysm']

entities_list: @entity5487 :: ('MESH:D014854', 'Disease') :: ['inferior cerebellar artery']

entities_list: @entity1662 :: ('MESH:D003244', 'Disease') :: ['impaired consciousness']

entities_list: @entity4265 :: ('MESH:C535682', 'Disease') :: ['right hemotympanum']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms']

answer: @entity5487 :: (MESH:D014854,Disease) :: ['aneurysm of the posterior inferior cerebellar artery']


abstract: The aim of this article was to evaluate the results of relapsed @entity5149 management using a simple frame construct of Ilizarov external fixator. Between 2003 and 2008, 18 feet in 13 @entity1 with relapsed @entity5149 were treated by Ilizarov external fixator. All @entity1 underwent previous surgery (1-3 operations). Average @entity1 age at the time of the operation was 5.5 years and the average follow-up period was 15.8 months. Midtarsal osteotomy was undertaken in 3 feet and soft tissue distraction was undertaken in 15 feet with no soft tissue release except in 3 feet that needed tendoachillis lengthening. The average time of fixator application was 4.5 months. Out of 18 feet, 2 (11.1%) were rated as excellent, 11 (61.1%) as good, 4 (22.2%) as fair, and 1 (5.6%) as poor. Excellent and good results (72.2%) were considered satisfactory, while fair and poor results (27.8%) were considered unsatisfactory. Thus, the Ilizarov technique gave satisfactory results in cases of relapsed @entity5149 that were difficult to treat by conventional methods. Longer follow-up is needed to assess the achieved correction and to detect any recurrence of the deformity.

title: The use of the Ilizarov method in management of relapsed XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5149 :: ('MESH:D003025', 'Disease') :: ['club feet', 'club foot']

answer: @entity5149 :: (MESH:D003025,Disease) :: ['club foot']


abstract: Percutaneous kyphoplasty is a minimally invasive technique that has become an effective and routine alternative for managing @entity3814 . This article reports the clinical outcome of a series of 54 cases of @entity3814 treated by percutaneous kyphoplasty. Fifty-four @entity1 with confirmed @entity170 and at least 1 level of thoracolumbar vertebrae compression @entity174 were retrospectively selected. Pre- and postoperative and last follow-up clinical evaluation and radiological data were analyzed, including change of visual analog scale (VAS), reduced use of painkillers, locomotor activity, Cobb's angle, and average vertebral body height. Mean follow-up was 20.4 months (range, 6-36 months). In all cases, percutaneous kyphoplasty treatment was successful, significantly increasing vertebral body height, diminishing @entity1513 in the fractured vertebrae, and decreasing painkiller use. In all @entity1 , percutaneous kyphoplasty partially or completely relieved back @entity158 . No new @entity85 was found within the follow-up period, nor were any other complications. The cement leakage rate was 3.86% (8 of 207 vertebrae) with percutaneous kyphoplasty, but no neurological or other complaints were received. Percutaneous kyphoplasty is a simple and safe procedure in managing @entity3814 . It relieves @entity158 quickly, restores vertebral height, prevents further @entity174 , and improves @entity1 quality of life.

title: Efficacy of percutaneous kyphoplasty in treating XXXX .

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity3814 :: ('MESH:D050815', 'Disease') :: ['osteoporotic thoracolumbar vertebrae compression fractures', 'osteoporotic vertebral compression fractures', 'osteoporotic vertebrae compression fractures']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['deformity']

answer: @entity3814 :: (MESH:D050815,Disease) :: ['osteoporotic multithoracolumbar vertebral compression fractures']


abstract: IMPORTANCE OF THE FIELD: In developed countries, colonoscopy volume has increased dramatically over the past 15 years and is the principle method used to screen for @entity694 . Preparations used for colon cleaning have evolved over the past 30 years. Some preparations have been shown to be unsafe and are now used on a limited basis. There has been progress on limiting the volume required and on taste improvement. AREAS COVERED IN THIS REVIEW: This review provides an account of preparations used from 1980 when @entity970 -based preparations became widely available, until the present day. The review highlights their mechanism of action and principle @entity137 . The handling of solutes and solute-free fluid by the colon is also reviewed. WHAT THE READER WILL GAIN: The reader will gain a perspective on the factors considered in developing colonic purgatives and the rationale for choosing selected preparations based on @entity1 factors such as age, co-morbidities and concomitant medications. TAKE HOME MESSAGE: Although generally safe and effective, colonic purgatives have both acute and permanent @entity137 . The safest preparations utilize @entity970 combined with a balanced electrolyte solution. Limitations of this preparation center on the volume required and poor taste. Alternative formulations are now available; however, those using @entity10457 have fallen out of favor due to a risk of @entity8 .

title: Mechanism of action and XXXX of purgatives used for colonoscopy preparation.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal toxicity']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity10457 :: ('MESH:C018279', 'Chemical') :: ['sodium phosphate']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicities']


abstract: UNASSIGNED: As a result of nuclear power plants accidents such as Chernobyl or Fukushima, some @entity1 were exposed to external and internal ionizing radiation (IR). @entity1 brain is highly sensitive to IR during fetal and postnatal period when the molecular processes are not completely finished. Various studies have shown that exposure to low doses of IR causes a higher incidence of @entity73 . On the other hand, in industrialized countries, @entity1 are daily exposed to a number of toxicant pollutants. Exposure to environmental chemicals, such as paraquat (PQ), may potentiate the toxic effects induced by radiation on brain development. In this study, we evaluated the cognitive effects of concomitant exposure to low doses of internal radiation ((137)Cs) and PQ during neonatal brain development. At the postnatal day 10 (PND10), two groups of @entity19 (C57BL/6J) were exposed to (137)Cs (4000 and 8000Bq/kg) and/or PQ (7mg/kg). To investigate the spontaneous behavior, learning, memory capacities and @entity148 , behavioral tests were conducted in the offspring at two months of age. The results showed that cognitive functions were not significantly affected when (137)Cs or PQ were administered alone. However, alterations in the working memory and @entity148 were detected in @entity19 exposed to (137)Cs combined with PQ.

title: Neurobehavioral effects of concurrent exposure to cesium-137 and paraquat during neonatal development in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Human', 'people']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND AND PURPOSE: The main objective of this study was to compare the hand and finger performance of @entity64 @entity1 in standing and sitting positions. METHODS: The study subjects were 11 males and 3 females with history of @entity64 (age, 68.6    6.3 years, mean    SD). Inclusion criteria were right-handedness before @entity64 , @entity1269 due to left hemisphere lesion induced by @entity64 , at least 4 months between @entity64 and study enrollment, and ability to stand for more than 10 minutes. Tests of dexterity (peg board test), attention, unilateral @entity1057 , and cognition were conducted in comfortable sitting and standing positions. Seven subjects started in standing position, and the other seven subjects were tested first in sitting position. Tests in the first position were performed on one day, and repeated one week later but performed in a different position. RESULTS: The mean performance time on the peg board test in standing position was significantly faster than in sitting position (p=0.022). However, the results of the @entity2205 making test-part A, line cancellation test, line bisection and Mini Mental State conducted in standing position were similar to those of sitting position. There were no differences between the first and second trial tests. CONCLUSIONS: Our results showed that standing position improved the functional performance of hand and arm on the un-affected side in @entity64 @entity1 , but had no effects on consistent attention, unilateral @entity1057 , or cognition.

title: Standing position improves arm and hand performance on un-affected side in hemiplegic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['right hemiparesis']

entities_list: @entity1057 :: ('MESH:D058069', 'Disease') :: ['spatial neglect']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To investigate the demographic, clinical, radiological, pathological and surgical features and outcomes of @entity1313 , the second most common @entity5 in @entity1 . @entity1 AND METHODS: We conducted a retrospective study in the Department of Pediatric Neurosurgery at the @entity6910 El-Reish @entity1 's Hospital from 2005 to 2008. RESULTS: Out of 451 @entity1 with primary @entity1313 (age 0-14 years), 21 @entity1 (<1 year) underwent surgery, representing 4.7% of total cases. The most common @entity5 was @entity2846 (23.8%), followed by @entity44 (19%) then @entity816 and @entity424 (14.3% each). Of the 21 surgical cases, 90% were intra-axial, 80% were in the supratentorial region, and 57% were intraventricular. There was only 1 case of intraoperative mortality (4.8%). Gross total excision was achieved in 65%, debulking in 30%, and biopsy in 5%. Three @entity1 received chemotherapy, but none received radiotherapy. The statistically significant predictors of prognosis were the extent of resection and @entity5 grade. CONCLUSION: Although the prognosis for @entity1313 is worse than for older @entity1 , an overall promising outcome with low operative morbidity and mortality was achieved using gross total excision and appropriate adjuvant chemotherapy as part of a multidisciplinary approach.

title: XXXX : characteristics and surgical outcomes of a contemporary series of 21 cases in an Egyptian referral center.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'PATIENTS', 'infants']

entities_list: @entity424 :: ('MESH:D004806', 'Disease') :: ['ependymoma']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['intracranial neoplasms', 'infantile intracranial neoplasms']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['astrocytoma']

entities_list: @entity2846 :: ('MESH:D020288', 'Disease') :: ['choroid plexus papilloma']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratoma']

answer: @entity1313 :: (MESH:D001932,Disease) :: ['Infantile intracranial neoplasms']


abstract: PURPOSE:: @entity15787 plays an important role in primary @entity751 ( @entity751 ) pathogenesis. The purpose of this study was to evaluate @entity15787 expression in tears and the conjunctiva and to analyze the impact of @entity15787 on primary @entity751 dry eyes. METHODS:: Eighty subjects were enrolled in this study: 30 @entity1 with @entity936 (30 eyes); 30 @entity1 with non- @entity751 dry eye (30 eyes), and 20 normal controls. Tear @entity15787 levels were measured by flow cytometry, and @entity15787 gene expression in the conjunctiva from impression cytology was evaluated by quantitative polymerase chain reaction. @entity2194 Index, tear film breakup time, Schirmer I test, and ocular surface staining scores were obtained for all @entity1 . RESULTS:: Primary @entity751 dry eyes had significantly higher tear @entity15787 levels than non- @entity751 dry eyes and normal controls (P < 0.01). In addition, @entity15787 gene expression in the conjunctiva was also higher in primary @entity751 dry eyes than in non- @entity751 dry eyes and normal controls (P < 0.01). However, there were no significant differences in @entity15787 expression in tears and the conjunctiva between non- @entity751 dry eyes and controls. The tear @entity15787 level was significantly correlated with ocular surface stain scores (r = 0.54, P < 0.01) and Schirmer I test values (r = -0.23, P < 0.05) in primary @entity751 dry eyes. CONCLUSIONS:: Our findings suggest that severity of @entity936 is associated with @entity15787 .

title: Association of @entity15787 Cytokine With Severity of Primary Sj  gren XXXX .

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['Ocular Surface Disease']

entities_list: @entity936 :: ('MESH:D015352', 'Disease') :: ['primary SS dry eye']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['Sj  gren syndrome', 'SS']

answer: @entity936 :: (MESH:D015352,Disease) :: ['Syndrome Dry Eye']


abstract: PURPOSE:: @entity15787 plays an important role in primary @entity751 ( @entity751 ) pathogenesis. The purpose of this study was to evaluate @entity15787 expression in tears and the conjunctiva and to analyze the impact of @entity15787 on primary @entity751 dry eyes. METHODS:: Eighty subjects were enrolled in this study: 30 @entity1 with @entity936 (30 eyes); 30 @entity1 with non- @entity751 dry eye (30 eyes), and 20 normal controls. Tear @entity15787 levels were measured by flow cytometry, and @entity15787 gene expression in the conjunctiva from impression cytology was evaluated by quantitative polymerase chain reaction. @entity2194 Index, tear film breakup time, Schirmer I test, and ocular surface staining scores were obtained for all @entity1 . RESULTS:: Primary @entity751 dry eyes had significantly higher tear @entity15787 levels than non- @entity751 dry eyes and normal controls (P < 0.01). In addition, @entity15787 gene expression in the conjunctiva was also higher in primary @entity751 dry eyes than in non- @entity751 dry eyes and normal controls (P < 0.01). However, there were no significant differences in @entity15787 expression in tears and the conjunctiva between non- @entity751 dry eyes and controls. The tear @entity15787 level was significantly correlated with ocular surface stain scores (r = 0.54, P < 0.01) and Schirmer I test values (r = -0.23, P < 0.05) in primary @entity751 dry eyes. CONCLUSIONS:: Our findings suggest that severity of @entity936 is associated with @entity15787 .

title: Association of XXXX Cytokine With Severity of Primary Sj  gren @entity936 .

answer: @entity15787 :: (59067,Gene) :: ['IL-21']


abstract: INTRODUCTION: @entity16546 is an @entity74 resulting in @entity2122 , and divided into types 1 and 2. Scoliosis has not been reported as one of the extra-cranial manifestations of @entity16546 . CASE PRESENTATION: We present a 14-year-old British Caucasian @entity1 with @entity16546 who developed a severe double thoracic @entity1635 measuring 39   and 68   respectively. Her @entity1635 was associated with @entity1514 , causing a marked reduction in the anteroposterior diameter of her chest and consequent severe @entity358 . The @entity85 was noted by her local pediatrician as part of a @entity5837 assessment when she was aged 13 years, and gradually progressed as the result of spinal growth. Our @entity1 underwent a posterior spinal arthrodesis using a single concave pedicle hook and screw rod construct and locally harvested autologous graft supplemented by allograft bone. This spinal fixation technique was selected because of our @entity1 's low body weight to avoid prominence of the instrumentation causing skin healing problems and @entity158 . Her @entity1635 was corrected to 18   and 30   and we achieved a balanced spine in the coronal and sagittal planes. An underarm spinal jacket was provided for six months after surgery. During her latest follow-up at skeletal maturity, our @entity1 had an excellent cosmetic outcome with no @entity85 correction or detected @entity1516 and a normal level of activities. CONCLUSION: Scoliosis can develop in young @entity1 with @entity16546 , with the @entity85 deteriorating around the pubertal growth spurt. Surgical treatment can correct the @entity85 , balance the spine and prevent @entity615 . It can also stabilize the chest area and avoid respiratory complications developing as the @entity1635 progresses, which can result in severe @entity358 . The use of single concave instrumentation is indicated in very slim @entity1 with poor muscle bulk; in our @entity1 , this produced satisfactory @entity85 correction and a favorable outcome at completion of growth. Peri-operative care in this group of @entity1 can be very challenging because of associated co-morbidities as well as the presence of severe behavioral issues that result in poor @entity1 compliance.

title: Surgical treatment of XXXX in @entity16546 : a case report.

entities_list: @entity2122 :: ('MESH:D019465', 'Disease') :: ['congenital craniofacial deformities']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girl', 'patients', 'patient']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic hypokyphosis']

entities_list: @entity5837 :: ('MESH:D056586', 'Disease') :: ['chest infection']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['mechanical back pain']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['restrictive lung disease', 'restrictive pulmonary disease']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal dominant disorder']

entities_list: @entity16546 :: ('MESH:D012415', 'Disease') :: ['Rubinstein-Taybi type 2 syndrome', 'Rubinstein-Taybi syndrome', 'Rubinstein-Taybi syndrome type 2']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['deformity', 'loss of deformity']

entities_list: @entity1516 :: ('MESH:D011542', 'Disease') :: ['pseudoarthrosis']

answer: @entity1635 :: (MESH:D012600,Disease) :: ['scoliosis']


abstract: INTRODUCTION: @entity16546 is an @entity74 resulting in @entity2122 , and divided into types 1 and 2. Scoliosis has not been reported as one of the extra-cranial manifestations of @entity16546 . CASE PRESENTATION: We present a 14-year-old British Caucasian @entity1 with @entity16546 who developed a severe double thoracic @entity1635 measuring 39   and 68   respectively. Her @entity1635 was associated with @entity1514 , causing a marked reduction in the anteroposterior diameter of her chest and consequent severe @entity358 . The @entity85 was noted by her local pediatrician as part of a @entity5837 assessment when she was aged 13 years, and gradually progressed as the result of spinal growth. Our @entity1 underwent a posterior spinal arthrodesis using a single concave pedicle hook and screw rod construct and locally harvested autologous graft supplemented by allograft bone. This spinal fixation technique was selected because of our @entity1 's low body weight to avoid prominence of the instrumentation causing skin healing problems and @entity158 . Her @entity1635 was corrected to 18   and 30   and we achieved a balanced spine in the coronal and sagittal planes. An underarm spinal jacket was provided for six months after surgery. During her latest follow-up at skeletal maturity, our @entity1 had an excellent cosmetic outcome with no @entity85 correction or detected @entity1516 and a normal level of activities. CONCLUSION: Scoliosis can develop in young @entity1 with @entity16546 , with the @entity85 deteriorating around the pubertal growth spurt. Surgical treatment can correct the @entity85 , balance the spine and prevent @entity615 . It can also stabilize the chest area and avoid respiratory complications developing as the @entity1635 progresses, which can result in severe @entity358 . The use of single concave instrumentation is indicated in very slim @entity1 with poor muscle bulk; in our @entity1 , this produced satisfactory @entity85 correction and a favorable outcome at completion of growth. Peri-operative care in this group of @entity1 can be very challenging because of associated co-morbidities as well as the presence of severe behavioral issues that result in poor @entity1 compliance.

title: Surgical treatment of @entity1635 in XXXX : a case report.

answer: @entity16546 :: (MESH:D012415,Disease) :: ['Rubinstein-Taybi syndrome type 2']


abstract: OBJECTIVES: To investigate Toll-like receptor activation in @entity1 skin using tape stripping and imiquimod cream challenges in healthy volunteers. SUBJECTS, TREATMENT AND METHODS: Seventeen male Caucasian subjects underwent a baseline biopsy on their lower back prior to two tape stripping procedures 7  days apart. Subjects were then treated with 5  % imiquimod for 2 and 4  days on separate sites in the same area. Further biopsies were taken 22-24  h after each challenge and mRNA and microRNA extracted and expression values analysed using robust statistical and pathway analysis methods. RESULTS: Fifteen of the 17 subjects completed the study according to protocol. No adverse events were associated with the procedures. A significant change (p  <  0.05, fold change >1.5 or <-1.5) in mRNA expression of 7,996 genes was evident in biopsies taken at both time points post tape stripping, compared to baseline biopsy expression values. The induction of mRNAs involved in various pathways including adhesion and migration was evident. mRNA markers representing inflammatory cells [e.g., @entity5750 , @entity12710 (p  <  0.0001)] and mRNAs encoding genes regulated by @entity3027 [e.g., @entity13434 , @entity22167 and @entity371 (p  <  0.0001)] were significantly up-regulated. @entity3027 and @entity371 proteins were detectable in exudates released 1 and 4  h post tape stripping. A putative signalling network associating these transcripts and six microRNAs (hsa-miR, -31, -132, -155, 548c, 548n and 574) was identified using a meta-regulation network model. microRNAs not previously associated with @entity3027 signalling have been identified. In contrast, only 223 known transcripts were significantly changed after imiquimod treatment, including @entity371 , and @entity22167 . CONCLUSION: Results suggest that @entity3027 signalling is important in these translational models and novel miRNA may be new targets in the treatment of @entity3027 associated @entity272 .

title: A model of skin inflammation in XXXX leads to a rapid and reproducible increase in the interferon response signature: a potential translational model for drug development.

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease']

entities_list: @entity3027 :: ('3439', 'Gene') :: ['IFNa', 'IFN', 'type 1 interferon (IFN)']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: UNASSIGNED: @entity740 is frequent and usually responsible of @entity79 . These abnormalities lead to increased morbidity and mortality. To become active, native vitamin  D needs a first hydroxylation in the liver, and a second one in the kidney. Next to its action on bone metabolism, vitamin  D also possesses pleiotropic actions on cardiovascular, immune and neurological systems as well as antineoplastic activities. @entity454 ( @entity454 ) is also associated with a decrease in vitamin  D activity by mechanisms including the increase of plasma phosphate concentration, secretion of @entity11648  and decrease in 1a-hydroxylase activity. The prevalence of 25  hydroxy- @entity41910 depends on the chosen cut-off value to define this lack. Currently it is well established that a @entity1 has to be substituted when 25  hydroxy-vitamin  D level is under 30  ng/mL. The use and monitoring of 1.25  hydroxy-vitamin  D is still not recommended in routine practice. The goals of vitamin  D treatment in case of @entity454 are to substitute the @entity942 or treat @entity2742 . Interest of native vitamin  D in first intention is now well demonstrated. This review article describes the vitamin  D metabolism and physiology and also the treatment for @entity41910 in @entity454 population.

title: [Native vitamin  D in dialysis XXXX .]

entities_list: @entity41910 :: ('MESH:D014808', 'Disease') :: ['vitamin  D deficiency']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['mineral and bone disorder']

entities_list: @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['deficiency and to prevent']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRD', 'End-stage renal disease']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND _ AIMS: Bioelectrical impedance analysis (BIA) provides a simple method to assess changes in body composition. Raw BIA variables such as phase angle provide direct information on cellular mass and integrity, without the assumptions inherent in estimating body compartments, e.g. @entity1386 ( @entity1386 ). Phase angle is a strong functional and prognostic marker in many disease states, but data in @entity1030 are lacking. Our aims were to describe the measurement of phase angle in @entity1 with stable @entity1030 and determine the construct and discriminate validity of phase angle by assessing its relationship with established markers of function, disease severity and prognosis. METHODS: 502 outpatients with stable @entity1030 were studied. Phase angle and @entity1386 by BIA, quadriceps strength (QMVC), 4-m gait speed (4MGS), 5 sit-to-stand time (5STS), incremental shuttle walk (ISW), and composite prognostic indices (ADO, iBODE) were measured. @entity1 were stratified into normal and low phase angle and @entity1386 index. RESULTS: Phase angle correlated positively with @entity1386 and functional outcomes (r  =  0.35-0.66, p  <  0.001) and negatively with prognostic indices (r  =  -0.35 to  -0.48, p  <  0.001). In regression models, phase angle was independently associated with ISW, ADO and iBODE whereas @entity1386 was removed. One hundred and seventy @entity1 (33.9% [95% CI, 29.9-38.1]) had a low phase angle. Phenotypic characteristics included lower QMVC, ISW, and 4MGS, higher 5STS, ADO and iBODE scores, and more exacerbations and hospital days in past year. The proportion of @entity1 to have died was significantly higher in @entity1 with low phase angle compared to those with normal phase angle (8.2% versus 3.6%, p  =  0.02). CONCLUSION: Phase angle relates to markers of function, disease severity and prognosis in @entity1 with @entity1030 . As a directly measured variable, phase angle offers more useful information than @entity1386 indices.

title: Bioelectrical impedance phase angle relates to function, disease severity and prognosis in stable XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['FFM', 'fat-free mass']

answer: @entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']


abstract: This work improved military nursing staff knowledge on selected mass gathering @entity166 at Hajj. The results showed that only (20%) of the participating nurses attended training program about health hazard during pilgrim. But only (40.0%) of them found the training programs were specific to nurses. Majority found the program useful (70.0%), and the average duration of this training program in weeks was 3.5+1.1. There was significant improvement P = < 0.001, of correct knowledge about @entity693 regarding causes, organisms, mode of spread, @entity1 at risk, transmission, prevention and treatment, the highest improvement was in causes of @entity693 the lowest was in adult vaccination. 25% of @entity1 had adequate knowledge (> 60% from total score) in pre-test 93% in post-test 72% after 3 month with significant difference among tests regarding adequate knowledge. There was significant improvement of correct knowledge P = <0.001 about seasonal influenza and @entity1576 during pilgrim, the highest improvement was in influenza vaccine strains the lowest was in antiviral drugs. 23% of nurses had adequate knowledge (> 60% from total score) in pre-test 94% in post-test 66% after 3 month with significant difference among tests regarding adequate knowledge. There was significant improvement P = < 0.001 of correct knowledge about @entity344 and @entity6766 during pilgrim among nurses at military hospital, the highest improvement was in risk factors of @entity6766 the lowest was in what GE @entity1 should do. 22% of @entity1 had adequate knowledge (> 60% from total score) in pre-test 91% in post-test 58% after 3 month with significant difference among tests regarding adequate knowledge. There was significant improvement P = < 0.001 of correct knowledge about heat exhaustion during pilgrim among nurses at military hospital, the highest improvement was in non-communicable diseases the lowest was in sun @entity64 prevention. 27% of @entity1 had adequate knowledge (> 60% from total score) in the pre-test 94% in the post-test 74% after 3 month with significant difference among pre, post and FU regarding adequate knowledge. Also, there were significant improvement P = < 0.001 of correct knowledge about @entity101 , @entity779 , @entity272 _ others diseases during pilgrim among nurses at military hospital, the highest improvement was in @entity272 prevention the lowest was in first aid bag. 28% of @entity1 had adequate knowledge (> 60% from total score) in the pre-test 92% in the post-test 61% after 3 month with significant difference among pre, post and FU regarding adequate knowledge. There was a significant difference between total knowledge score according to education, and work experience (P > 0.05). in the pre, post and after 3 month in age and in all intervention time in department the highest was ICU then ward then operation room.

title: An interventional program for nursing staff on selected mass gathering XXXX at Hajj.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'patient', 'people']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6766 :: ('MESH:D005517', 'Disease') :: ['food poisoning']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal diseases']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory diseases']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin scalding']

entities_list: @entity779 :: ('MESH:D003715', 'Disease') :: ['dengue fever']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases']

answer: @entity166 :: (MESH:D003141,Disease) :: ['infectious diseases']


abstract: BACKGROUND: Intraplaque @entity548 is a widely known factor facilitating plaque instability. Neovascularization of plaque can be regarded as a compensatory response to the blood supply in the deep intimal and medial areas of the artery. Due to the physiological function, the deformation of @entity2998 would happen under the action of blood pressure and blood flow. Neovessels are subject to mechanical loading and likely undergo deformation. The @entity397 of neovessels may deteriorate the instability of plaque. This study focuses on the local mechanical environments around neovessels and investigates the relationship between the biomechanics and the morphological specificity of neovessels. METHODS: Stress and stretch were used to evaluate the @entity397 risk of the neovessels in plaque. Computational structural analysis was performed based on two @entity1 carotid plaque slice samples. Two-dimensional models containing neovessels and other components were built according to the plaque slice samples. Each component was assumed to be non-linear isotropic, piecewise homogeneous and incompressible. Different mechanical boundary conditions, i.e. static pressures, were imposed in the carotid lumen and neovessels lumen respectively. Finite element method was used to simulate the mechanical conditions in the @entity731 . RESULTS: Those neovessels closer to the carotid lumen undergo larger stress and stretch. With the same distance to the carotid lumen, the longer the perimeter of neovessels is, the larger stress and the deformation of the neovessels will be. Under the same conditions, the neovessels with larger curvature suffer greater stress and stretch. Neovessels surrounded by red blood cells undergo a much larger stretch. CONCLUSIONS: Local mechanical conditions may result in the @entity548 of neovessels and accelerate the @entity397 . The mechanical environments of the neovessel are related to its shape, curvature, distance to the carotid lumen and the material properties of plaque.

title: Finite element analysis of mechanics of neovessels with intraplaque @entity548 in XXXX .

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerotic plaque']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture', 'rupture of plaque']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic plaque']

answer: @entity2998 :: (MESH:D002340,Disease) :: ['carotid atherosclerosis']


abstract: BACKGROUND: Intraplaque @entity548 is a widely known factor facilitating plaque instability. Neovascularization of plaque can be regarded as a compensatory response to the blood supply in the deep intimal and medial areas of the artery. Due to the physiological function, the deformation of @entity2998 would happen under the action of blood pressure and blood flow. Neovessels are subject to mechanical loading and likely undergo deformation. The @entity397 of neovessels may deteriorate the instability of plaque. This study focuses on the local mechanical environments around neovessels and investigates the relationship between the biomechanics and the morphological specificity of neovessels. METHODS: Stress and stretch were used to evaluate the @entity397 risk of the neovessels in plaque. Computational structural analysis was performed based on two @entity1 carotid plaque slice samples. Two-dimensional models containing neovessels and other components were built according to the plaque slice samples. Each component was assumed to be non-linear isotropic, piecewise homogeneous and incompressible. Different mechanical boundary conditions, i.e. static pressures, were imposed in the carotid lumen and neovessels lumen respectively. Finite element method was used to simulate the mechanical conditions in the @entity731 . RESULTS: Those neovessels closer to the carotid lumen undergo larger stress and stretch. With the same distance to the carotid lumen, the longer the perimeter of neovessels is, the larger stress and the deformation of the neovessels will be. Under the same conditions, the neovessels with larger curvature suffer greater stress and stretch. Neovessels surrounded by red blood cells undergo a much larger stretch. CONCLUSIONS: Local mechanical conditions may result in the @entity548 of neovessels and accelerate the @entity397 . The mechanical environments of the neovessel are related to its shape, curvature, distance to the carotid lumen and the material properties of plaque.

title: Finite element analysis of mechanics of neovessels with intraplaque XXXX in @entity2998 .

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhage']


abstract: Eighteen @entity5 @entity1 receiving intensive chemotherapy developed @entity1431 , @entity221 , @entity1282 , and oropharyngeal soreness. Superficial esophageal ulceration suggestive of @entity2910 was demonstrated by radiographic examination in 33% of the @entity1 (5/15). Upper gastrointestinal endoscopy revealed superficial ulceration and white mucosal patches in all @entity1 . There was no morbidity associated with the endoscopic procedures. Sixty-one percent of the @entity1 (11/18) had monilia albicans cultured from the oropharyngeal cavity, and 50% (9/18) had monilia cultured from the esophageal lesions. The evolution of the @entity2910 correlated well with the survival of the @entity1 . The @entity2910 persisted in six @entity1 who all died within 24 days of @entity7553 . After initial improvement five additional @entity1 succumbed; three of them from severe @entity364 . There was resolution of the @entity2910 in the remaining seven @entity1 who survived longer. However, two of them had recurrent @entity2910 and succumbed to @entity6923 . The other five have remained free of @entity2910 , their underlying @entity5 have remained under control, and so far they have survived an average of one and a half years. Endoscopy is more accurate than radiography in detecting @entity2910 . This complication can be fatal, since it is often followed by @entity6923 .

title: XXXX : the endoscopic diagnosis and its impact on survival.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6923 :: ('MESH:C536777', 'Disease') :: ['systemic candidiasis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancies']

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis', 'postchemotherapy esophagitis', 'monilial esophagitis']

entities_list: @entity7553 :: ('MESH:D002177', 'Disease') :: ['systemic moniliasis']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infection']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

answer: @entity2910 :: (MESH:D004941,Disease) :: ['Postchemotherapy esophagitis']


abstract: BACKGROUND: This study aims to assess the prevalence of @entity851 among a nationally representative sample of Iranian adolescents according to the socioeconomic status (SES) of their living area. METHODS: This nationwide cross-sectional survey was conducted among a representative sample of 5624 adolescents aged 10-18 years. They were selected by multistage cluster sampling from 27 provinces of Iran. Subnational classification of the country was based on geography and social class of each region. Analysis of variance and Chi-square tests were used to compare the prevalence of @entity851 according to sex and SES of the living regions. RESULTS: The mean and standard deviation for body mass index was 19.42 (4.09) kg/m(2), with a significant trend from the Southeast region with lowest SES to the Central part with highest SES (ptrend  <  0.001). The prevalence of @entity28 , combined overweight and @entity28 , as well as abdominal adiposity increased with a significant trend from low to high SES (all ptrend  <  0.001, except for @entity1 ' height, ptrend  =  0.003). The opposite direction was documented for the prevalence of underweight and short stature, with the highest frequencies in the Southeast (lowest SES) and the lowest in Central part (highest SES). CONCLUSION: Excess weight was more prevalent in high SES regions, whereas underweight and short stature were more prevalent in low SES regions. These findings underscore the necessity of implementing evidence-based health promotion programs and preventive strategies according to SES.

title: Prevalence of XXXX in a Nationally Representative Sample of Iranian Adolescents According to Socioeconomic Status: The CASPIAN-III Study.

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['growth disorders']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity851 :: (MESH:D006130,Disease) :: ['Growth Disorders']


abstract: OBJECTIVE AND DESIGN: We sought to determine the effect of @entity39 -induced activation of the complement protein C3 in @entity2946 . MATERIALS/METHODS: Twelve @entity2946 surgical specimens were evaluated for complement activation using immunohistochemistry, with H_E stains performed on adjacent tissue sections to determine the relationship of complement activation to @entity39 tissue. Flow cytometry and Western blot were performed on three established @entity2946 lines and one surgically-procured cell culture to determine expression of @entity54597 ( @entity54597 ) in @entity2946 . In vitro proliferation of siRNA @entity54597 knockdown cells was compared to that of control siRNA cells with cell line Daoy. RESULTS: Three surgical specimens were found to have @entity39 on H_E sections. In each case, iC3b staining was identified on adjacent sections, limited to the @entity39 region. In no case did @entity39 occur without iC3b staining on adjacent sections. @entity54597 protein was demonstrated on both the three established cell lines and on the surgical culture. Proliferation assays of @entity1 cells with siRNA knockdown vs. control siRNA revealed significantly reduced proliferation at 72  h (p  =  0.001). CONCLUSIONS: @entity39 is associated with complement activation in @entity2946 . @entity2946 cells express @entity54597 , and siRNA-mediated knockdown of @entity54597 inhibits proliferation of these cells in vitro.

title: Tumor @entity39 -initiated complement activation stimulates proliferation of XXXX cells.

entities_list: @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma', 'Medulloblastoma']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic', 'necrosis', 'Necrosis']

answer: @entity2946 :: (MESH:D008527,Disease) :: ['medulloblastoma']


abstract: OBJECTIVE AND DESIGN: We sought to determine the effect of @entity39 -induced activation of the complement protein C3 in @entity2946 . MATERIALS/METHODS: Twelve @entity2946 surgical specimens were evaluated for complement activation using immunohistochemistry, with H_E stains performed on adjacent tissue sections to determine the relationship of complement activation to @entity39 tissue. Flow cytometry and Western blot were performed on three established @entity2946 lines and one surgically-procured cell culture to determine expression of @entity54597 ( @entity54597 ) in @entity2946 . In vitro proliferation of siRNA @entity54597 knockdown cells was compared to that of control siRNA cells with cell line Daoy. RESULTS: Three surgical specimens were found to have @entity39 on H_E sections. In each case, iC3b staining was identified on adjacent sections, limited to the @entity39 region. In no case did @entity39 occur without iC3b staining on adjacent sections. @entity54597 protein was demonstrated on both the three established cell lines and on the surgical culture. Proliferation assays of @entity1 cells with siRNA knockdown vs. control siRNA revealed significantly reduced proliferation at 72  h (p  =  0.001). CONCLUSIONS: @entity39 is associated with complement activation in @entity2946 . @entity2946 cells express @entity54597 , and siRNA-mediated knockdown of @entity54597 inhibits proliferation of these cells in vitro.

title: Tumor XXXX -initiated complement activation stimulates proliferation of @entity2946 cells.

answer: @entity39 :: (MESH:D009336,Disease) :: ['necrosis']


abstract: OBJECTIVE: To evaluate the relationship between clinical or @entity1375 and positive thyroid autoantibody before 20 weeks pregnancy and risk of @entity600 . METHODS: Literature search was done in PubMed, EMBASE, Wanfang Medical Database, @entity4207 Database and China Biology Medicine disc databases from January 1st, 1980 to December 31th, 2013. The following search terms were used: @entity1375 , @entity1375 , hypothyroxinnism, thyroid antibody, @entity3152 , @entity600 , etc. (1) Criteria for inclusion:cohort studies and clinical studies were included; only articles that described at least 10 @entity1 were eligible;the exposure was clinical or @entity1375 and positive thyroid autoantihody, and outcome was @entity600 . (2) The excluded subjects were articles that described less than 10 @entity1 ; controls were pregnant @entity1 without eurothyrodisim. Meta-analysis was performed by RevMan 5. The relationship between clinical or @entity1375 and positive thyroid autoantibody and risk of @entity600 was evaluated by OR or RR. RESULTS: (1) Twenty cohort studies were enrolled. A total of 39 596 cases of @entity600 occurred among 498 418 pregnant @entity1 . The controls in these studies were pregnant @entity1 with eurothyrodisim. (2) @entity1375 in pregnancy: eight studies were included, reported data on 478 418 pregnant @entity1 (5 473 @entity1 with clinical @entity1375 and 472 945 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with clinical @entity1375 was higher than those eurothyroid pregnant @entity1 in control group (OR = 1.25, 95% CI:1.15-1.36, P < 0.01). (3) @entity1375 in pregnancy: ten studies were included, reported data on 277 531 pregnant @entity1 (5 257 @entity1 with @entity1375 and 272 274 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with @entity1375 was higher than those in control group by random effects analysis (OR = 1.25, 95% CI:1.14-1.36, P < 0.01). (4) Thyroid autoantibodys positive in pregnancy:eleven studies were included, reported data on 28 781 pregnant @entity1 (3 036 @entity1 with @entity1374 745 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with positive thyroid autoantibody was higher than those negative thyroid autoantibody in control group (OR = 1.47, 95% CI: 1.27- 1.70, P < 0.01). The funnel plots presented symmetrical graphics, indicating that there was no publication bias. CONCLUSION: Clinical or @entity1375 and positive thyroid autoantibody in pregnant @entity1 is risk factors of @entity600 .

title: [Clinical or @entity1375 and thyroid autoantibody before 20 weeks pregnancy and risk of XXXX : a systematic review].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism', 'hypothyroidism', 'Subclinical hypothyroidism', 'Clinical hypothyroidism']

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm labor']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth']

entities_list: @entity4207 :: ('MESH:D007859', 'Disease') :: ['China Academic Journal Network Publishing']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid autoanti body positive and 25']

answer: @entity600 :: (MESH:D000014,Disease) :: ['preterm birth']


abstract: OBJECTIVE: To evaluate the relationship between clinical or @entity1375 and positive thyroid autoantibody before 20 weeks pregnancy and risk of @entity600 . METHODS: Literature search was done in PubMed, EMBASE, Wanfang Medical Database, @entity4207 Database and China Biology Medicine disc databases from January 1st, 1980 to December 31th, 2013. The following search terms were used: @entity1375 , @entity1375 , hypothyroxinnism, thyroid antibody, @entity3152 , @entity600 , etc. (1) Criteria for inclusion:cohort studies and clinical studies were included; only articles that described at least 10 @entity1 were eligible;the exposure was clinical or @entity1375 and positive thyroid autoantihody, and outcome was @entity600 . (2) The excluded subjects were articles that described less than 10 @entity1 ; controls were pregnant @entity1 without eurothyrodisim. Meta-analysis was performed by RevMan 5. The relationship between clinical or @entity1375 and positive thyroid autoantibody and risk of @entity600 was evaluated by OR or RR. RESULTS: (1) Twenty cohort studies were enrolled. A total of 39 596 cases of @entity600 occurred among 498 418 pregnant @entity1 . The controls in these studies were pregnant @entity1 with eurothyrodisim. (2) @entity1375 in pregnancy: eight studies were included, reported data on 478 418 pregnant @entity1 (5 473 @entity1 with clinical @entity1375 and 472 945 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with clinical @entity1375 was higher than those eurothyroid pregnant @entity1 in control group (OR = 1.25, 95% CI:1.15-1.36, P < 0.01). (3) @entity1375 in pregnancy: ten studies were included, reported data on 277 531 pregnant @entity1 (5 257 @entity1 with @entity1375 and 272 274 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with @entity1375 was higher than those in control group by random effects analysis (OR = 1.25, 95% CI:1.14-1.36, P < 0.01). (4) Thyroid autoantibodys positive in pregnancy:eleven studies were included, reported data on 28 781 pregnant @entity1 (3 036 @entity1 with @entity1374 745 euthyroid pregnant @entity1 ). The risk of @entity600 in pregnant @entity1 with positive thyroid autoantibody was higher than those negative thyroid autoantibody in control group (OR = 1.47, 95% CI: 1.27- 1.70, P < 0.01). The funnel plots presented symmetrical graphics, indicating that there was no publication bias. CONCLUSION: Clinical or @entity1375 and positive thyroid autoantibody in pregnant @entity1 is risk factors of @entity600 .

title: [Clinical or XXXX and thyroid autoantibody before 20 weeks pregnancy and risk of @entity600 : a systematic review].

answer: @entity1375 :: (MESH:D007037,Disease) :: ['subclinical hypothyroidism']


abstract: Crossed @entity2026 is reported to be more frequent in traumatic series than in series of @entity1 with other pathologies. A right-handed young @entity1 suffered a closed- @entity542 and became aphasic and hemiparetic on the left. CT scan revealed a @entity75 . Neuropsychological examination revealed a fluent @entity2026 and a @entity1052 . These signs were compatible with left @entity71152 . However, the presence of a @entity75 suggested that this @entity1 could be a crossed aphasic. Subsequent EEG study showed a left occipitotemporal focus and a right frontal one. Aphasic signs could thus be due to the @entity75 , which was the result of a contrecoup mechanism. Fluent aphasias have been reported in closed- @entity542 with right frontal impact. Attention is called for the possible bias of including cases like this in series of traumatic crossed @entity2026 .

title: Contrecoup injury in the misdiagnosis of crossed XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity1052 :: ('MESH:D005862', 'Disease') :: ['Gerstmann syndrome']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['right frontal-lobe lesion', 'right frontal-lobe hematoma', 'left lesion']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head trauma']

entities_list: @entity71152 :: ('MESH:C564353', 'Disease') :: ['supramarginal gyrus syndrome']

answer: @entity2026 :: (MESH:D001037,Disease) :: ['aphasia']


abstract: A typing scheme for @entity2718 based on slide agglutination with rabbit antisera was previously described. It allows the differentiation of 10 serogroups designated A, B, C, D, F, G, H, I, K, and X. We studied the correlation between serogrouping and @entity2975 gel electrophoresis (PAGE) of whole-cell proteins. A total of 202 isolates from different sources were analyzed by PAGE after ultrasonic disintegration of cells from an 18-h liquid culture and treatment with @entity3208 and @entity6514 . A total of 21 different patterns were observed. The reference strains from the 10 serogroups showed different profiles. For each serogroup except A, the patterns obtained with the clinical isolates were identical to the patterns obtained with the reference strains. For the 48 strains belonging to serogroup A, 12 different profiles were observed. Five of these involved strains isolated from patients with antibiotic-associated @entity294 . Typing by @entity3208 -PAGE thus correlates with serogrouping. In addition, it allows discrimination within the heterogeneous serogroup A.

title: Comparison of serogrouping and @entity2975 gel electrophoresis for typing XXXX .

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecyl sulfate']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity6514 :: ('MESH:D008623', 'Chemical') :: ['2-mercaptoethanol']

entities_list: @entity2718 :: ('1496', 'Species') :: ['Clostridium difficile']

answer: @entity2718 :: (1496,Species) :: ['Clostridium difficile']


abstract: A typing scheme for @entity2718 based on slide agglutination with rabbit antisera was previously described. It allows the differentiation of 10 serogroups designated A, B, C, D, F, G, H, I, K, and X. We studied the correlation between serogrouping and @entity2975 gel electrophoresis (PAGE) of whole-cell proteins. A total of 202 isolates from different sources were analyzed by PAGE after ultrasonic disintegration of cells from an 18-h liquid culture and treatment with @entity3208 and @entity6514 . A total of 21 different patterns were observed. The reference strains from the 10 serogroups showed different profiles. For each serogroup except A, the patterns obtained with the clinical isolates were identical to the patterns obtained with the reference strains. For the 48 strains belonging to serogroup A, 12 different profiles were observed. Five of these involved strains isolated from patients with antibiotic-associated @entity294 . Typing by @entity3208 -PAGE thus correlates with serogrouping. In addition, it allows discrimination within the heterogeneous serogroup A.

title: Comparison of serogrouping and XXXX gel electrophoresis for typing @entity2718 .

answer: @entity2975 :: (CHEBI:51135,Chemical) :: ['polyacrylamide']


abstract: OBJECTIVE: The aim of this study was to evaluate the efficacy, impact on quality of life, and safety of pregabalin for the treatment of @entity697 ( @entity697 ) and @entity9 ( @entity9 ). DESIGN: Multicenter, parallel-group, single-blind, 4-week, randomized clinical trial. SETTING: Conducted in the department of @entity158 clinic of participating hospitals. SUBJECTS: Three hundred @entity1 with @entity697 or @entity9 (of which 239 completed the study). METHODS: @entity1 were treated with oxycodone (A group) or combination of oxycodone and pregabalin (B group). @entity1 with @entity697 belonged to A1 group and B1 group. @entity1 with @entity9 belonged to A2 group and B2 group. @entity158 intensity was rated on an 11-point numerical rating scale (NRS). Other outcomes included mean daily oxycodone doses, quality of life, and adverse effects. RESULTS: Pregabalin-treated @entity1 had greater NRS decrement: 74% in B1 (vs 58% in A1; P   <   0.05); 69% in B2 (vs 53% in A2; P   <   0.05). Significant improvement in quality of life was observed in all groups, and pregabalin-treated @entity1 improved more, with 72.7% in B1 (vs 63.7% in A1; P   <   0.05) and 74.5% in B2 (vs 59.6% in A2; P   <   0.05). The maximum tolerated dose of oxycodone for pregabalin-treated @entity1 was lower. Pregabalin had acceptable tolerability. CONCLUSIONS: Both combination therapy with oxycodone plus pregabalin and oxycodone monotherapy were effective and safe for @entity9 . In addition, subjects on combination therapy showed shortened time to @entity158 relief, reduced @entity158 intensity, and greater improvement than oxycodone alone.

title: Pregabalin in the treatment of XXXX : results of a multicenter chinese study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['AHN', 'acute herpetic neuralgia']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['herpetic neuralgia', 'subacute herpetic neuralgia', 'SHN']

answer: @entity9 :: (MESH:D009437,Disease) :: ['herpetic neuralgia']


abstract: AIMS: The @entity2182 symptom score (OABSS) is a useful tool for assessing the four key symptoms of @entity2182 ( @entity2182 ), but it sometimes misrepresents a @entity1 's actual voiding status. To examine whether the @entity1 -determined OABSS underestimates or overestimates the true status, its results were compared to those of the OABSS derived from a 7-day bladder diary (OABSS-BD). METHODS: Records of @entity1 who visited our outpatient clinic with lower urinary tract symptoms were evaluated retrospectively. The @entity1 were asked to complete the OABSS and the 7-day bladder diary (BD). The OABSS-BD was created from the 7-day BD. Questions were compared between the OABSS and the OABSS-BD. RESULTS: A total of 44 @entity1 and 31 @entity1 were evaluated. For daytime frequency, the mean OABSS score was 1.03        0.57 and the OABSS-BD score was 0.69        0.52 (P   <   0.01). For nighttime frequency, the mean OABSS score was 2.27        0.84, and the OABSS-BD score was 1.96        1.00 (P   =   0.04). For urinary urgency, the mean OABSS score was 2.49        1.83, and the OABSS-BD score was 2.70        1.90 (P   =   0.27). For urgency incontinence, the mean OABSS score was 1.67        1.92, and the OABSS-BD score was 1.52        1.87 (P   =   0.28). For the total score, the mean OABSS total score was 7.26        3.92, and the OABSS-BD score was 6.98        3.26 (P   =   0.23). CONCLUSIONS: The OABSS is a very simple and useful tool. However, compared to the results from the 7-day FVC, the present @entity1 overestimated daytime and nighttime frequency. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Comparison of the XXXX symptom score and the @entity2182 symptom score derived from the bladder diaries.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity2182 :: ('MESH:D053201', 'Disease') :: ['overactive bladder', 'OAB']

answer: @entity2182 :: (MESH:D053201,Disease) :: ['overactive bladder']


abstract: AIMS: The @entity2182 symptom score (OABSS) is a useful tool for assessing the four key symptoms of @entity2182 ( @entity2182 ), but it sometimes misrepresents a @entity1 's actual voiding status. To examine whether the @entity1 -determined OABSS underestimates or overestimates the true status, its results were compared to those of the OABSS derived from a 7-day bladder diary (OABSS-BD). METHODS: Records of @entity1 who visited our outpatient clinic with lower urinary tract symptoms were evaluated retrospectively. The @entity1 were asked to complete the OABSS and the 7-day bladder diary (BD). The OABSS-BD was created from the 7-day BD. Questions were compared between the OABSS and the OABSS-BD. RESULTS: A total of 44 @entity1 and 31 @entity1 were evaluated. For daytime frequency, the mean OABSS score was 1.03        0.57 and the OABSS-BD score was 0.69        0.52 (P   <   0.01). For nighttime frequency, the mean OABSS score was 2.27        0.84, and the OABSS-BD score was 1.96        1.00 (P   =   0.04). For urinary urgency, the mean OABSS score was 2.49        1.83, and the OABSS-BD score was 2.70        1.90 (P   =   0.27). For urgency incontinence, the mean OABSS score was 1.67        1.92, and the OABSS-BD score was 1.52        1.87 (P   =   0.28). For the total score, the mean OABSS total score was 7.26        3.92, and the OABSS-BD score was 6.98        3.26 (P   =   0.23). CONCLUSIONS: The OABSS is a very simple and useful tool. However, compared to the results from the 7-day FVC, the present @entity1 overestimated daytime and nighttime frequency. Neurourol. Urodynam.    2015 Wiley Periodicals, Inc.

title: Comparison of the @entity2182 symptom score and the XXXX symptom score derived from the bladder diaries.

answer: @entity2182 :: (MESH:D053201,Disease) :: ['overactive bladder']


abstract: A new @entity43 cell line has been established from the dispersed cells taken from a heterotransplanted @entity5 at the 6th passage in @entity19 which had been serially transplanted with a @entity75 of @entity189 (FIGO) of the ovary. Selection of cancerous epithelioid cells was completed by the 4th passage by means of the colonial cloning method. The cell line designated TYK-nu was subcultured serially in Eagle's MEM with 10% FCS more than 100 times over 31 months at March, 1986 and was observed to produce a @entity5 on implantation into @entity19 histologically similar to the @entity5 . These cells form a monolayer in a pavement-like arrangement with polygonal cells including giant cells and reveal a lack of contact inhibition. PAS positive substance can be seen in the cytoplasm. Desmosome structure, well-developed cell organelles and glycogen granules can be found by electron microscopy. The population doubling time was about 37 hours and the plating efficiency was 13-17%. All cells were seen to be of the @entity1 karyotype on chromosomal analysis and the number of chromosome in the majority of cells was hyperdiploidy with a mode of 56 at the 6th and 84th passages. A submetacentric marker chromosome was present. Using in vitro colony assay, TYK-nu was studied for drug sensitivity to @entity900 , @entity632 , @entity1891 , @entity1487 and @entity2879 , and found to be sensitive to @entity900 .

title: [Establishment of a cell line from @entity1 @entity43 ( XXXX of FIGO classification) and analysis of its cell-biological characteristics and sensitivity to anticancer drugs].

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'original tumor']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['undifferentiated carcinoma']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity189 :: (MESH:D002277,Disease) :: ['undifferentiated carcinoma']


abstract: A new @entity43 cell line has been established from the dispersed cells taken from a heterotransplanted @entity5 at the 6th passage in @entity19 which had been serially transplanted with a @entity75 of @entity189 (FIGO) of the ovary. Selection of cancerous epithelioid cells was completed by the 4th passage by means of the colonial cloning method. The cell line designated TYK-nu was subcultured serially in Eagle's MEM with 10% FCS more than 100 times over 31 months at March, 1986 and was observed to produce a @entity5 on implantation into @entity19 histologically similar to the @entity5 . These cells form a monolayer in a pavement-like arrangement with polygonal cells including giant cells and reveal a lack of contact inhibition. PAS positive substance can be seen in the cytoplasm. Desmosome structure, well-developed cell organelles and glycogen granules can be found by electron microscopy. The population doubling time was about 37 hours and the plating efficiency was 13-17%. All cells were seen to be of the @entity1 karyotype on chromosomal analysis and the number of chromosome in the majority of cells was hyperdiploidy with a mode of 56 at the 6th and 84th passages. A submetacentric marker chromosome was present. Using in vitro colony assay, TYK-nu was studied for drug sensitivity to @entity900 , @entity632 , @entity1891 , @entity1487 and @entity2879 , and found to be sensitive to @entity900 .

title: [Establishment of a cell line from @entity1 XXXX ( @entity189 of FIGO classification) and analysis of its cell-biological characteristics and sensitivity to anticancer drugs].

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: A new @entity43 cell line has been established from the dispersed cells taken from a heterotransplanted @entity5 at the 6th passage in @entity19 which had been serially transplanted with a @entity75 of @entity189 (FIGO) of the ovary. Selection of cancerous epithelioid cells was completed by the 4th passage by means of the colonial cloning method. The cell line designated TYK-nu was subcultured serially in Eagle's MEM with 10% FCS more than 100 times over 31 months at March, 1986 and was observed to produce a @entity5 on implantation into @entity19 histologically similar to the @entity5 . These cells form a monolayer in a pavement-like arrangement with polygonal cells including giant cells and reveal a lack of contact inhibition. PAS positive substance can be seen in the cytoplasm. Desmosome structure, well-developed cell organelles and glycogen granules can be found by electron microscopy. The population doubling time was about 37 hours and the plating efficiency was 13-17%. All cells were seen to be of the @entity1 karyotype on chromosomal analysis and the number of chromosome in the majority of cells was hyperdiploidy with a mode of 56 at the 6th and 84th passages. A submetacentric marker chromosome was present. Using in vitro colony assay, TYK-nu was studied for drug sensitivity to @entity900 , @entity632 , @entity1891 , @entity1487 and @entity2879 , and found to be sensitive to @entity900 .

title: [Establishment of a cell line from XXXX @entity43 ( @entity189 of FIGO classification) and analysis of its cell-biological characteristics and sensitivity to anticancer drugs].

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: We investigated whether extracorporeal shock wave (ECSW) therapy can attenuate cyclophosphamide (CYP)-induced @entity2335 ( @entity2335 ) in @entity35 . METHODS AND RESULTS: Eighteen male-adult @entity35 were equally divided into group 1 (sham control), group 2 ( @entity2335 induced by 150 mg/kg CYP by intra-peritoneal injection) and group 3 ( @entity2335 + ECSW 200 impulses at 0.11 mJ/mm(2) to the urinary bladder at 3 and 24 h after CYP treatment). Smooth-muscle cells co-culture with menadione (25   M) with and without ECSW treatment was performed. Western-blot results demonstrated that ECSW significant attenuated oxidative stress and inflammatory reactions in this in-vitro studies (all p < 0.001). 24-hour urine amount and microscopic findings of red-blood-cell count (i.e., @entity811 ) were higher in group 2 than in groups 1 and 3, and significantly higher in group 3 than in group 1 (all p < 0.001). The urine levels of albumin and @entity568 showed an identical pattern of @entity811 among all three groups (all p < 0.001). The cellular and mRNA expressions of @entity23346 ( @entity19984 )+, @entity26832 +, @entity22519 +, substance p+, and @entity4665 + cells in the bladder tissue exhibited an identical pattern of @entity811 among all groups (all p < 0.0001). The integrity of epithelial layer and collagen-deposition area as stained by Sirius red displayed an opposite pattern of @entity811 among the three groups (p < 0.0001). The protein expression of IL-12, @entity1506 , @entity1505 , @entity4026 , @entity6929 , @entity12613 , @entity8562 , @entity16620 , and Oxyblot displayed an identical pattern of @entity811 among all groups (all p < 0.01). CONCLUSION: ECSW therapy markedly attenuated CYP-induced @entity2335 through inhibitions of the @entity32 and oxidative stress.

title: Extracorporeal shock wave therapy ameliorates cyclophosphamide-induced @entity35 XXXX though inhibiting @entity32 and oxidative stress-in vitro and in vivo experiment studies.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

entities_list: @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria']

entities_list: @entity2335 :: ('MESH:D003556', 'Disease') :: ['AIC', 'acute interstitial cystitis']

entities_list: @entity23346 :: ('103694877', 'Gene') :: ['macrophage migration inhibitory factor']

answer: @entity2335 :: (MESH:D003556,Disease) :: ['acute interstitial cystitis']


abstract: BACKGROUND: We investigated whether extracorporeal shock wave (ECSW) therapy can attenuate cyclophosphamide (CYP)-induced @entity2335 ( @entity2335 ) in @entity35 . METHODS AND RESULTS: Eighteen male-adult @entity35 were equally divided into group 1 (sham control), group 2 ( @entity2335 induced by 150 mg/kg CYP by intra-peritoneal injection) and group 3 ( @entity2335 + ECSW 200 impulses at 0.11 mJ/mm(2) to the urinary bladder at 3 and 24 h after CYP treatment). Smooth-muscle cells co-culture with menadione (25   M) with and without ECSW treatment was performed. Western-blot results demonstrated that ECSW significant attenuated oxidative stress and inflammatory reactions in this in-vitro studies (all p < 0.001). 24-hour urine amount and microscopic findings of red-blood-cell count (i.e., @entity811 ) were higher in group 2 than in groups 1 and 3, and significantly higher in group 3 than in group 1 (all p < 0.001). The urine levels of albumin and @entity568 showed an identical pattern of @entity811 among all three groups (all p < 0.001). The cellular and mRNA expressions of @entity23346 ( @entity19984 )+, @entity26832 +, @entity22519 +, substance p+, and @entity4665 + cells in the bladder tissue exhibited an identical pattern of @entity811 among all groups (all p < 0.0001). The integrity of epithelial layer and collagen-deposition area as stained by Sirius red displayed an opposite pattern of @entity811 among the three groups (p < 0.0001). The protein expression of IL-12, @entity1506 , @entity1505 , @entity4026 , @entity6929 , @entity12613 , @entity8562 , @entity16620 , and Oxyblot displayed an identical pattern of @entity811 among all groups (all p < 0.01). CONCLUSION: ECSW therapy markedly attenuated CYP-induced @entity2335 through inhibitions of the @entity32 and oxidative stress.

title: Extracorporeal shock wave therapy ameliorates cyclophosphamide-induced @entity35 @entity2335 though inhibiting XXXX and oxidative stress-in vitro and in vivo experiment studies.

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: BACKGROUND: We investigated whether extracorporeal shock wave (ECSW) therapy can attenuate cyclophosphamide (CYP)-induced @entity2335 ( @entity2335 ) in @entity35 . METHODS AND RESULTS: Eighteen male-adult @entity35 were equally divided into group 1 (sham control), group 2 ( @entity2335 induced by 150 mg/kg CYP by intra-peritoneal injection) and group 3 ( @entity2335 + ECSW 200 impulses at 0.11 mJ/mm(2) to the urinary bladder at 3 and 24 h after CYP treatment). Smooth-muscle cells co-culture with menadione (25   M) with and without ECSW treatment was performed. Western-blot results demonstrated that ECSW significant attenuated oxidative stress and inflammatory reactions in this in-vitro studies (all p < 0.001). 24-hour urine amount and microscopic findings of red-blood-cell count (i.e., @entity811 ) were higher in group 2 than in groups 1 and 3, and significantly higher in group 3 than in group 1 (all p < 0.001). The urine levels of albumin and @entity568 showed an identical pattern of @entity811 among all three groups (all p < 0.001). The cellular and mRNA expressions of @entity23346 ( @entity19984 )+, @entity26832 +, @entity22519 +, substance p+, and @entity4665 + cells in the bladder tissue exhibited an identical pattern of @entity811 among all groups (all p < 0.0001). The integrity of epithelial layer and collagen-deposition area as stained by Sirius red displayed an opposite pattern of @entity811 among the three groups (p < 0.0001). The protein expression of IL-12, @entity1506 , @entity1505 , @entity4026 , @entity6929 , @entity12613 , @entity8562 , @entity16620 , and Oxyblot displayed an identical pattern of @entity811 among all groups (all p < 0.01). CONCLUSION: ECSW therapy markedly attenuated CYP-induced @entity2335 through inhibitions of the @entity32 and oxidative stress.

title: Extracorporeal shock wave therapy ameliorates cyclophosphamide-induced XXXX @entity2335 though inhibiting @entity32 and oxidative stress-in vitro and in vivo experiment studies.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Experiments were carried out to establish whether infusion of relaxin prolongs gestation and labour in the @entity35 by suppressing release of @entity398 , and whether the effects of relaxin on birth could be reversed by the opioid antagonist @entity1510 . Female @entity35 were implanted with subcutaneous osmotic minipumps for the infusion of purified porcine relaxin into the jugular vein for 84 h from either day 19 or day 20 of gestation. Infusion of relaxin delayed the onset of labour and in those animals which delivered during relaxin infusion, delivery was longer by approximately 45 min. Plasma @entity398 levels 40 min after delivery of the first fetus were 45.25 +/- 3.6 pmol/l (mean +/- S.D.) in unoperated controls and significantly (P less than 0.01) depressed (23.89 +/- 3.9) in @entity35 that delivered during infusion of relaxin. @entity35 that delivered after the infusion of relaxin had finished, gave birth significantly (P less than 0.05) faster than controls and plasma @entity398 levels were significantly (P less than 0.01) raised (77.87 +/- 15.9 pmol/l). @entity1510 treatment (1 mg/kg; i.m.) given immediately after the delivery of the first fetus reversed the inhibitory effect of relaxin and the interval between successive deliveries was slightly faster than that of controls. Plasma @entity398 levels in relaxin-infused @entity1510 -treated @entity35 were significantly (P less than 0.01) higher than values in unoperated control @entity35 . The results confirm that relaxin suppresses @entity398 release possibly through an opioid system and this may be important in the control of the timing of birth.

title: Relaxin acts centrally to inhibit XXXX release during parturition: an effect that is reversed by @entity1510 .

entities_list: @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin']

entities_list: @entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone', 'naloxone']

answer: @entity398 :: (MESH:D010121,Chemical) :: ['oxytocin']


abstract: Experiments were carried out to establish whether infusion of relaxin prolongs gestation and labour in the @entity35 by suppressing release of @entity398 , and whether the effects of relaxin on birth could be reversed by the opioid antagonist @entity1510 . Female @entity35 were implanted with subcutaneous osmotic minipumps for the infusion of purified porcine relaxin into the jugular vein for 84 h from either day 19 or day 20 of gestation. Infusion of relaxin delayed the onset of labour and in those animals which delivered during relaxin infusion, delivery was longer by approximately 45 min. Plasma @entity398 levels 40 min after delivery of the first fetus were 45.25 +/- 3.6 pmol/l (mean +/- S.D.) in unoperated controls and significantly (P less than 0.01) depressed (23.89 +/- 3.9) in @entity35 that delivered during infusion of relaxin. @entity35 that delivered after the infusion of relaxin had finished, gave birth significantly (P less than 0.05) faster than controls and plasma @entity398 levels were significantly (P less than 0.01) raised (77.87 +/- 15.9 pmol/l). @entity1510 treatment (1 mg/kg; i.m.) given immediately after the delivery of the first fetus reversed the inhibitory effect of relaxin and the interval between successive deliveries was slightly faster than that of controls. Plasma @entity398 levels in relaxin-infused @entity1510 -treated @entity35 were significantly (P less than 0.01) higher than values in unoperated control @entity35 . The results confirm that relaxin suppresses @entity398 release possibly through an opioid system and this may be important in the control of the timing of birth.

title: Relaxin acts centrally to inhibit @entity398 release during parturition: an effect that is reversed by XXXX .

answer: @entity1510 :: (MESH:D009270,Chemical) :: ['naloxone']