abstract: UNASSIGNED: Intralesional injection with @entity228 remains the mainstay of therapy for @entity2805 and @entity12347 , however some lesions are unresponsive or may result in @entity272 . Intralesional @entity1732 injection is an alternative therapy that has been widely reported. In order to compare the effectiveness and safety of @entity1732 for the treatment of @entity12347 and @entity2805 in skin of color population, Fitzpatrick skin type III to V @entity1 with @entity12347 or @entity2805 were randomized into two groups. Group A was treated monthly with intralesional @entity2995 (10  mg/mL), while group B with intralesional @entity1732 (1  mg/mL) for three consecutive months. Evaluation of the treatment was performed using " @entity1 and Observer Scar Assessment Scale" (POSAS), self-rated @entity1 satisfaction score, photography, and ultrasonography. Two @entity1 had their @entity1732 blood levels monitored. Twenty-six @entity1 with @entity12347 or @entity2805 were recruited. The clinical improvement as assessed by the POSAS was not statistically significant. In terms of @entity1 satisfaction score, one half of both groups reported a very good improvement. Photographic as well as ultrasonographic evaluation showed no difference between the two groups. @entity1732 was found to enter the blood circulation in a very small amount. The major side effect was @entity2117 . There was no @entity272 detected in this study. Intralesional @entity1732 is a safe and effective treatment for @entity12347 and @entity2805 . The treatment is comparable to intralesional @entity2713 . Unfortunately, @entity2117 was the major side effect in darker skin type.

title: The Treatment of XXXX and @entity2805 with intralesional @entity1732 in skin of color.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide']

entities_list: @entity2117 :: ('MESH:D017495', 'Disease') :: ['hyperpigmentation']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity2805 :: ('MESH:D017439', 'Disease') :: ['hypertrophic scars']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['Bleomycin', 'bleomycin']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin atrophy']

entities_list: @entity2713 :: ('MESH:D014221', 'Chemical') :: ['triamcinolone']

answer: @entity12347 :: (MESH:D007627,Disease) :: ['keloids']


abstract: UNASSIGNED: Intralesional injection with @entity228 remains the mainstay of therapy for @entity2805 and @entity12347 , however some lesions are unresponsive or may result in @entity272 . Intralesional @entity1732 injection is an alternative therapy that has been widely reported. In order to compare the effectiveness and safety of @entity1732 for the treatment of @entity12347 and @entity2805 in skin of color population, Fitzpatrick skin type III to V @entity1 with @entity12347 or @entity2805 were randomized into two groups. Group A was treated monthly with intralesional @entity2995 (10  mg/mL), while group B with intralesional @entity1732 (1  mg/mL) for three consecutive months. Evaluation of the treatment was performed using " @entity1 and Observer Scar Assessment Scale" (POSAS), self-rated @entity1 satisfaction score, photography, and ultrasonography. Two @entity1 had their @entity1732 blood levels monitored. Twenty-six @entity1 with @entity12347 or @entity2805 were recruited. The clinical improvement as assessed by the POSAS was not statistically significant. In terms of @entity1 satisfaction score, one half of both groups reported a very good improvement. Photographic as well as ultrasonographic evaluation showed no difference between the two groups. @entity1732 was found to enter the blood circulation in a very small amount. The major side effect was @entity2117 . There was no @entity272 detected in this study. Intralesional @entity1732 is a safe and effective treatment for @entity12347 and @entity2805 . The treatment is comparable to intralesional @entity2713 . Unfortunately, @entity2117 was the major side effect in darker skin type.

title: The Treatment of @entity12347 and XXXX with intralesional @entity1732 in skin of color.

answer: @entity2805 :: (MESH:D017439,Disease) :: ['hypertrophic scars']


abstract: UNASSIGNED: Intralesional injection with @entity228 remains the mainstay of therapy for @entity2805 and @entity12347 , however some lesions are unresponsive or may result in @entity272 . Intralesional @entity1732 injection is an alternative therapy that has been widely reported. In order to compare the effectiveness and safety of @entity1732 for the treatment of @entity12347 and @entity2805 in skin of color population, Fitzpatrick skin type III to V @entity1 with @entity12347 or @entity2805 were randomized into two groups. Group A was treated monthly with intralesional @entity2995 (10  mg/mL), while group B with intralesional @entity1732 (1  mg/mL) for three consecutive months. Evaluation of the treatment was performed using " @entity1 and Observer Scar Assessment Scale" (POSAS), self-rated @entity1 satisfaction score, photography, and ultrasonography. Two @entity1 had their @entity1732 blood levels monitored. Twenty-six @entity1 with @entity12347 or @entity2805 were recruited. The clinical improvement as assessed by the POSAS was not statistically significant. In terms of @entity1 satisfaction score, one half of both groups reported a very good improvement. Photographic as well as ultrasonographic evaluation showed no difference between the two groups. @entity1732 was found to enter the blood circulation in a very small amount. The major side effect was @entity2117 . There was no @entity272 detected in this study. Intralesional @entity1732 is a safe and effective treatment for @entity12347 and @entity2805 . The treatment is comparable to intralesional @entity2713 . Unfortunately, @entity2117 was the major side effect in darker skin type.

title: The Treatment of @entity12347 and @entity2805 with intralesional XXXX in skin of color.

answer: @entity1732 :: (MESH:D001761,Chemical) :: ['bleomycin']


abstract: BACKGROUND: The mechanism of @entity205 ( @entity870 )-induced nephrotoxicity has been suggested to be vasoconstriction due to reduced @entity842 (NO), providing tissue @entity82 by elevation of transforming growth factor beta and @entity6667 ( @entity6667 ). In this study using a @entity35 model of CsA-induced nephrotoxicity, we administered a phosphodiesterase-5 inhibitor to ameliorate the @entity8 and alter the expression of endothelial No synthase (eNOS) and @entity6667 . METHODS: A right nephrectomy was performed in @entity35 (n = 30; 200-250 g, all male). The @entity63 group (n = 6) underwent ligation of the @entity8 for 45 minutes (IR) before observation for 28 days. After IR, the @entity28281 group (n = 6) was treated with 10 mg/kg drug orally, the CsA group (n = 6) received 15 mg/kg CsA injected subcutaneously and the CsA plus @entity28281 group (n = 6) received 15 mg/kg CsA injected subcutaneously together with the oral administration of 10 mg/kg @entity28281 . RESULTS: Administration of @entity28281 significantly decreased serum @entity1011 either alone (0.21    0.04 mg/dL) or in combination with CsA (1.86    0.35 mg/dL) versus the @entity63 (0.85    0.22 mg/dL) and the CsA alone (3. 10    0.77 mg/dL) group. (P = .002; P = .002). Comparing the @entity1710 - @entity1711 staining of the @entity63 (0.41    0.09) and CsA (0.44    0.08) groups showed a significantly decreased loss of nuclei in proximal tubules after the administration of @entity28281 (0.27    0.05 [P = .004] and 0.26    0.02 [P = .002] respectively). Immunohistochemical staining showed strong eNOS staining in the @entity28281 and CsA plus @entity28281 groups. Western blots for eNOS showed decreased expression in the CsA group and increased expression in the @entity28281 group. Western blots for @entity6667 revealed reduced expression only in the CsA plus @entity28281 group. eNOS mRNA was decreased in the CsA (0.017    0.010) compared with the @entity63 group (0.048    0.015; P = .000). @entity6667 mRNA which was decreased in the CsA group (2.026    1.109), showed greater tendency after administration of @entity28281 (0.440    0.449) (P = .003). CONCLUSION: The phosphodiesterase inhibitor ameliorated @entity8 in a @entity35 model of CsA-induced nephrotoxicity, possibly related to increased eNOS and reduced @entity6667 expression.

title: Effects of a cGMP-specific phosphodiesterase inhibitor on expression of endothelial @entity842 synthase and @entity6667 in @entity35 with XXXX -induced nephrotoxicity.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['left renal artery', 'renal injury']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemia']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['Hematoxylin']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity35 :: ('10116', 'Species') :: ['rat', 'Sprague-Dawley rats']

entities_list: @entity6667 :: ('83785(Tax:10116)', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

answer: @entity205 :: (MESH:D016572,Chemical) :: ['cyclosporine']


abstract: BACKGROUND: The mechanism of @entity205 ( @entity870 )-induced nephrotoxicity has been suggested to be vasoconstriction due to reduced @entity842 (NO), providing tissue @entity82 by elevation of transforming growth factor beta and @entity6667 ( @entity6667 ). In this study using a @entity35 model of CsA-induced nephrotoxicity, we administered a phosphodiesterase-5 inhibitor to ameliorate the @entity8 and alter the expression of endothelial No synthase (eNOS) and @entity6667 . METHODS: A right nephrectomy was performed in @entity35 (n = 30; 200-250 g, all male). The @entity63 group (n = 6) underwent ligation of the @entity8 for 45 minutes (IR) before observation for 28 days. After IR, the @entity28281 group (n = 6) was treated with 10 mg/kg drug orally, the CsA group (n = 6) received 15 mg/kg CsA injected subcutaneously and the CsA plus @entity28281 group (n = 6) received 15 mg/kg CsA injected subcutaneously together with the oral administration of 10 mg/kg @entity28281 . RESULTS: Administration of @entity28281 significantly decreased serum @entity1011 either alone (0.21    0.04 mg/dL) or in combination with CsA (1.86    0.35 mg/dL) versus the @entity63 (0.85    0.22 mg/dL) and the CsA alone (3. 10    0.77 mg/dL) group. (P = .002; P = .002). Comparing the @entity1710 - @entity1711 staining of the @entity63 (0.41    0.09) and CsA (0.44    0.08) groups showed a significantly decreased loss of nuclei in proximal tubules after the administration of @entity28281 (0.27    0.05 [P = .004] and 0.26    0.02 [P = .002] respectively). Immunohistochemical staining showed strong eNOS staining in the @entity28281 and CsA plus @entity28281 groups. Western blots for eNOS showed decreased expression in the CsA group and increased expression in the @entity28281 group. Western blots for @entity6667 revealed reduced expression only in the CsA plus @entity28281 group. eNOS mRNA was decreased in the CsA (0.017    0.010) compared with the @entity63 group (0.048    0.015; P = .000). @entity6667 mRNA which was decreased in the CsA group (2.026    1.109), showed greater tendency after administration of @entity28281 (0.440    0.449) (P = .003). CONCLUSION: The phosphodiesterase inhibitor ameliorated @entity8 in a @entity35 model of CsA-induced nephrotoxicity, possibly related to increased eNOS and reduced @entity6667 expression.

title: Effects of a cGMP-specific phosphodiesterase inhibitor on expression of endothelial XXXX synthase and @entity6667 in @entity35 with @entity205 -induced nephrotoxicity.

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: BACKGROUND: The mechanism of @entity205 ( @entity870 )-induced nephrotoxicity has been suggested to be vasoconstriction due to reduced @entity842 (NO), providing tissue @entity82 by elevation of transforming growth factor beta and @entity6667 ( @entity6667 ). In this study using a @entity35 model of CsA-induced nephrotoxicity, we administered a phosphodiesterase-5 inhibitor to ameliorate the @entity8 and alter the expression of endothelial No synthase (eNOS) and @entity6667 . METHODS: A right nephrectomy was performed in @entity35 (n = 30; 200-250 g, all male). The @entity63 group (n = 6) underwent ligation of the @entity8 for 45 minutes (IR) before observation for 28 days. After IR, the @entity28281 group (n = 6) was treated with 10 mg/kg drug orally, the CsA group (n = 6) received 15 mg/kg CsA injected subcutaneously and the CsA plus @entity28281 group (n = 6) received 15 mg/kg CsA injected subcutaneously together with the oral administration of 10 mg/kg @entity28281 . RESULTS: Administration of @entity28281 significantly decreased serum @entity1011 either alone (0.21    0.04 mg/dL) or in combination with CsA (1.86    0.35 mg/dL) versus the @entity63 (0.85    0.22 mg/dL) and the CsA alone (3. 10    0.77 mg/dL) group. (P = .002; P = .002). Comparing the @entity1710 - @entity1711 staining of the @entity63 (0.41    0.09) and CsA (0.44    0.08) groups showed a significantly decreased loss of nuclei in proximal tubules after the administration of @entity28281 (0.27    0.05 [P = .004] and 0.26    0.02 [P = .002] respectively). Immunohistochemical staining showed strong eNOS staining in the @entity28281 and CsA plus @entity28281 groups. Western blots for eNOS showed decreased expression in the CsA group and increased expression in the @entity28281 group. Western blots for @entity6667 revealed reduced expression only in the CsA plus @entity28281 group. eNOS mRNA was decreased in the CsA (0.017    0.010) compared with the @entity63 group (0.048    0.015; P = .000). @entity6667 mRNA which was decreased in the CsA group (2.026    1.109), showed greater tendency after administration of @entity28281 (0.440    0.449) (P = .003). CONCLUSION: The phosphodiesterase inhibitor ameliorated @entity8 in a @entity35 model of CsA-induced nephrotoxicity, possibly related to increased eNOS and reduced @entity6667 expression.

title: Effects of a cGMP-specific phosphodiesterase inhibitor on expression of endothelial @entity842 synthase and XXXX in @entity35 with @entity205 -induced nephrotoxicity.

answer: @entity6667 :: (83785(Tax:10116),Gene) :: ['vascular endothelial growth factor']


abstract: BACKGROUND: The mechanism of @entity205 ( @entity870 )-induced nephrotoxicity has been suggested to be vasoconstriction due to reduced @entity842 (NO), providing tissue @entity82 by elevation of transforming growth factor beta and @entity6667 ( @entity6667 ). In this study using a @entity35 model of CsA-induced nephrotoxicity, we administered a phosphodiesterase-5 inhibitor to ameliorate the @entity8 and alter the expression of endothelial No synthase (eNOS) and @entity6667 . METHODS: A right nephrectomy was performed in @entity35 (n = 30; 200-250 g, all male). The @entity63 group (n = 6) underwent ligation of the @entity8 for 45 minutes (IR) before observation for 28 days. After IR, the @entity28281 group (n = 6) was treated with 10 mg/kg drug orally, the CsA group (n = 6) received 15 mg/kg CsA injected subcutaneously and the CsA plus @entity28281 group (n = 6) received 15 mg/kg CsA injected subcutaneously together with the oral administration of 10 mg/kg @entity28281 . RESULTS: Administration of @entity28281 significantly decreased serum @entity1011 either alone (0.21    0.04 mg/dL) or in combination with CsA (1.86    0.35 mg/dL) versus the @entity63 (0.85    0.22 mg/dL) and the CsA alone (3. 10    0.77 mg/dL) group. (P = .002; P = .002). Comparing the @entity1710 - @entity1711 staining of the @entity63 (0.41    0.09) and CsA (0.44    0.08) groups showed a significantly decreased loss of nuclei in proximal tubules after the administration of @entity28281 (0.27    0.05 [P = .004] and 0.26    0.02 [P = .002] respectively). Immunohistochemical staining showed strong eNOS staining in the @entity28281 and CsA plus @entity28281 groups. Western blots for eNOS showed decreased expression in the CsA group and increased expression in the @entity28281 group. Western blots for @entity6667 revealed reduced expression only in the CsA plus @entity28281 group. eNOS mRNA was decreased in the CsA (0.017    0.010) compared with the @entity63 group (0.048    0.015; P = .000). @entity6667 mRNA which was decreased in the CsA group (2.026    1.109), showed greater tendency after administration of @entity28281 (0.440    0.449) (P = .003). CONCLUSION: The phosphodiesterase inhibitor ameliorated @entity8 in a @entity35 model of CsA-induced nephrotoxicity, possibly related to increased eNOS and reduced @entity6667 expression.

title: Effects of a cGMP-specific phosphodiesterase inhibitor on expression of endothelial @entity842 synthase and @entity6667 in XXXX with @entity205 -induced nephrotoxicity.

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: Objective To assess the association of the @entity71916 ( @entity41599 ) polymorphism of the gene @entity8166 in the @entity6 with the need for additional treatment and the occurrence of large newborns for the gestational age. Subjects and methods One hundred and five @entity1 recruited in Joinville - Brazil were evaluated between November 2010 and October 2012. Pregnant @entity1 were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. The variants of the polymorphism @entity71916 were identified by restriction fragment lengths polymorphisms (RFLP). Anthropometric and biochemical parameters of the mother and the newborn, and the necessity of additional therapy associated with diet were assessed as the primary outcomes. Results Thirty-five point two percent of the evaluated @entity1 carried at least one mutated allele of @entity71916 polymorphism. There were no significant differences in @entity1017 , parity, age, body mass index and gestational age of arrival at maternity between the two groups. The groups of @entity1 with or without the mutated allele did not differ in the need for additional treatment associated with diet (16.2% vs. 26.7%) respectively and with the occurrence of large newborns for gestational age (24.3% vs. 13.2%). Conclusion Our data showed that the polymorphism @entity71916 of the gene @entity8166 had no effect in the need for additional treatment associated with the diet-based therapy and in the occurrence of large newborns for gestational age in the studied population. Arq Bras Endocrinol Metab. 2014;58(9):900-5.

title: [Study of polymorphism @entity71916 of XXXX gene in @entity6 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['gestational diabetes mellitus']

entities_list: @entity71916 :: ('p|SUB|G|54|D', 'ProteinMutation') :: ['G54D']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

answer: @entity8166 :: (4153,Gene) :: ['MBL2']


abstract: Objective To assess the association of the @entity71916 ( @entity41599 ) polymorphism of the gene @entity8166 in the @entity6 with the need for additional treatment and the occurrence of large newborns for the gestational age. Subjects and methods One hundred and five @entity1 recruited in Joinville - Brazil were evaluated between November 2010 and October 2012. Pregnant @entity1 were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. The variants of the polymorphism @entity71916 were identified by restriction fragment lengths polymorphisms (RFLP). Anthropometric and biochemical parameters of the mother and the newborn, and the necessity of additional therapy associated with diet were assessed as the primary outcomes. Results Thirty-five point two percent of the evaluated @entity1 carried at least one mutated allele of @entity71916 polymorphism. There were no significant differences in @entity1017 , parity, age, body mass index and gestational age of arrival at maternity between the two groups. The groups of @entity1 with or without the mutated allele did not differ in the need for additional treatment associated with diet (16.2% vs. 26.7%) respectively and with the occurrence of large newborns for gestational age (24.3% vs. 13.2%). Conclusion Our data showed that the polymorphism @entity71916 of the gene @entity8166 had no effect in the need for additional treatment associated with the diet-based therapy and in the occurrence of large newborns for gestational age in the studied population. Arq Bras Endocrinol Metab. 2014;58(9):900-5.

title: [Study of polymorphism @entity71916 of @entity8166 gene in XXXX ].

answer: @entity6 :: (MESH:D003920,Disease) :: ['gestational diabetes mellitus']


abstract: Objective To assess the association of the @entity71916 ( @entity41599 ) polymorphism of the gene @entity8166 in the @entity6 with the need for additional treatment and the occurrence of large newborns for the gestational age. Subjects and methods One hundred and five @entity1 recruited in Joinville - Brazil were evaluated between November 2010 and October 2012. Pregnant @entity1 were divided in two groups correspondents to the presence (n = 37) or absence (n = 68) of the mutant allele. The variants of the polymorphism @entity71916 were identified by restriction fragment lengths polymorphisms (RFLP). Anthropometric and biochemical parameters of the mother and the newborn, and the necessity of additional therapy associated with diet were assessed as the primary outcomes. Results Thirty-five point two percent of the evaluated @entity1 carried at least one mutated allele of @entity71916 polymorphism. There were no significant differences in @entity1017 , parity, age, body mass index and gestational age of arrival at maternity between the two groups. The groups of @entity1 with or without the mutated allele did not differ in the need for additional treatment associated with diet (16.2% vs. 26.7%) respectively and with the occurrence of large newborns for gestational age (24.3% vs. 13.2%). Conclusion Our data showed that the polymorphism @entity71916 of the gene @entity8166 had no effect in the need for additional treatment associated with the diet-based therapy and in the occurrence of large newborns for gestational age in the studied population. Arq Bras Endocrinol Metab. 2014;58(9):900-5.

title: [Study of polymorphism XXXX of @entity8166 gene in @entity6 ].

answer: @entity71916 :: (p|SUB|G|54|D,ProteinMutation) :: ['G54D']


abstract: AIM: To determine whether short-term intensive group-based therapy combining modified constraint-induced movement therapy and bimanual therapy (hybrid- @entity6481 ) is more effective than an equal total dose of distributed individualized occupational therapy (standard care) on upper limb motor and individualized outcomes. METHOD: Fifty-three @entity1 with @entity306 (69% males; mean age 7y 10mo, SD 2y 4mo; Manual Ability Classification System level I, n=24; level II, n=23) were randomly allocated, and 44 received either hybrid- @entity6481 (n=25) or standard care (n=19). Standard care comprised six weekly occupational therapy sessions and a 12-week home programme. Outcomes were assessed at baseline, 13  weeks, and 26  weeks after treatment. RESULTS: Groups were equivalent at baseline. Standard care achieved greater gains on satisfaction with occupational performance after intervention (estimated mean difference -1.2, 95% CI -2.2 to -0.1; p=0.04) and Assisting Hand Assessment at 26  weeks (estimated mean difference 3.1, 95% CI 0.2-6.0; p=0.04). Both groups demonstrated significant improvements in dexterity of the @entity3140 , and bimanual and occupational performance over time. The differences between groups were not clinically meaningful. INTERPRETATION: There were no differences between the two models of therapy delivery. Group-based intensive camps may not be readily available; however, individualized standard care augmented with a home programme may offer an effective alternative but needs to be provided at a sufficient dose.

title: Randomized comparison trial of density and context of upper limb intensive group versus individualized occupational therapy for @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity3140 :: ('MESH:D038062', 'Disease') :: ['impaired upper limb']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['unilateral cerebral palsy']

answer: @entity306 :: (MESH:D002547,Disease) :: ['unilateral cerebral palsy']


abstract: AIM: To determine whether short-term intensive group-based therapy combining modified constraint-induced movement therapy and bimanual therapy (hybrid- @entity6481 ) is more effective than an equal total dose of distributed individualized occupational therapy (standard care) on upper limb motor and individualized outcomes. METHOD: Fifty-three @entity1 with @entity306 (69% males; mean age 7y 10mo, SD 2y 4mo; Manual Ability Classification System level I, n=24; level II, n=23) were randomly allocated, and 44 received either hybrid- @entity6481 (n=25) or standard care (n=19). Standard care comprised six weekly occupational therapy sessions and a 12-week home programme. Outcomes were assessed at baseline, 13  weeks, and 26  weeks after treatment. RESULTS: Groups were equivalent at baseline. Standard care achieved greater gains on satisfaction with occupational performance after intervention (estimated mean difference -1.2, 95% CI -2.2 to -0.1; p=0.04) and Assisting Hand Assessment at 26  weeks (estimated mean difference 3.1, 95% CI 0.2-6.0; p=0.04). Both groups demonstrated significant improvements in dexterity of the @entity3140 , and bimanual and occupational performance over time. The differences between groups were not clinically meaningful. INTERPRETATION: There were no differences between the two models of therapy delivery. Group-based intensive camps may not be readily available; however, individualized standard care augmented with a home programme may offer an effective alternative but needs to be provided at a sufficient dose.

title: Randomized comparison trial of density and context of upper limb intensive group versus individualized occupational therapy for XXXX with @entity306 .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND:: Both @entity1875 infusions with @entity26 delivered through nasal cannula and @entity5161 / @entity3727 ( @entity3810 ) delivered via a laryngeal mask airway (LMA) are used to provide anesthesia for @entity1 undergoing magnetic resonance imaging scans. We compared the incidence of adverse events and perioperative physiologic responses in @entity1 anesthetized with these 2 regimens. METHODS:: One hundred-fifty healthy @entity1 , ages 1 to 10 years, were randomized to receive either a @entity1875 infusion (starting at 300   g kg  min) with @entity26 via nasal cannula (n = 75) or @entity5161 with 70% @entity3727 in @entity26 delivered via an LMA (n = 75), both after a @entity2614 / @entity3727 / @entity26 induction. Adverse airway events, as well as hemodynamic, respiratory, and other physiologic responses were recorded during the magnetic resonance imaging scans and in the postanesthesia care unit by a single research nurse who was blind to the treatments. All parents were contacted postoperatively to complete a postanesthetic follow-up. RESULTS:: All 150 @entity1 completed their scans. The frequency of all adverse airway events during emergence and recovery after @entity1875 (12%) was significantly less than that after @entity5161 / @entity3727 /LMA (49%) (95% confidence interval for the risk difference was 23%-50%) (P = 0.0001). Hemodynamic responses and recovery times for the 2 treatments were similar. Early recovery, defined as the time interval from admission to the postanesthesia care unit until eye opening and wakefulness (modified Aldrete score >5), after @entity1875 was more rapid than that after @entity5161 / @entity3727 /LMA (P = 0.0001 and P = 0.0012, respectively). No scans had to be repeated. CONCLUSIONS:: The frequency of adverse airway events during emergence and recovery after @entity1875 infusion with @entity26 by nasal cannula is less than with @entity5161 / @entity3727 /LMA in @entity1 .

title: @entity1875 Anesthesia for @entity1 Undergoing Magnetic Resonance Imaging: A Comparison with XXXX , @entity3810 , and a Laryngeal Mask Airway.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

entities_list: @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide']

entities_list: @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane']

entities_list: @entity5161 :: ('MESH:D007530', 'Chemical') :: ['isoflurane']

answer: @entity5161 :: (MESH:D007530,Chemical) :: ['Isoflurane']


abstract: BACKGROUND:: Both @entity1875 infusions with @entity26 delivered through nasal cannula and @entity5161 / @entity3727 ( @entity3810 ) delivered via a laryngeal mask airway (LMA) are used to provide anesthesia for @entity1 undergoing magnetic resonance imaging scans. We compared the incidence of adverse events and perioperative physiologic responses in @entity1 anesthetized with these 2 regimens. METHODS:: One hundred-fifty healthy @entity1 , ages 1 to 10 years, were randomized to receive either a @entity1875 infusion (starting at 300   g kg  min) with @entity26 via nasal cannula (n = 75) or @entity5161 with 70% @entity3727 in @entity26 delivered via an LMA (n = 75), both after a @entity2614 / @entity3727 / @entity26 induction. Adverse airway events, as well as hemodynamic, respiratory, and other physiologic responses were recorded during the magnetic resonance imaging scans and in the postanesthesia care unit by a single research nurse who was blind to the treatments. All parents were contacted postoperatively to complete a postanesthetic follow-up. RESULTS:: All 150 @entity1 completed their scans. The frequency of all adverse airway events during emergence and recovery after @entity1875 (12%) was significantly less than that after @entity5161 / @entity3727 /LMA (49%) (95% confidence interval for the risk difference was 23%-50%) (P = 0.0001). Hemodynamic responses and recovery times for the 2 treatments were similar. Early recovery, defined as the time interval from admission to the postanesthesia care unit until eye opening and wakefulness (modified Aldrete score >5), after @entity1875 was more rapid than that after @entity5161 / @entity3727 /LMA (P = 0.0001 and P = 0.0012, respectively). No scans had to be repeated. CONCLUSIONS:: The frequency of adverse airway events during emergence and recovery after @entity1875 infusion with @entity26 by nasal cannula is less than with @entity5161 / @entity3727 /LMA in @entity1 .

title: @entity1875 Anesthesia for @entity1 Undergoing Magnetic Resonance Imaging: A Comparison with @entity5161 , XXXX , and a Laryngeal Mask Airway.

answer: @entity3810 :: (MESH:D009609,Chemical) :: ['Nitrous Oxide']


abstract: BACKGROUND:: Both @entity1875 infusions with @entity26 delivered through nasal cannula and @entity5161 / @entity3727 ( @entity3810 ) delivered via a laryngeal mask airway (LMA) are used to provide anesthesia for @entity1 undergoing magnetic resonance imaging scans. We compared the incidence of adverse events and perioperative physiologic responses in @entity1 anesthetized with these 2 regimens. METHODS:: One hundred-fifty healthy @entity1 , ages 1 to 10 years, were randomized to receive either a @entity1875 infusion (starting at 300   g kg  min) with @entity26 via nasal cannula (n = 75) or @entity5161 with 70% @entity3727 in @entity26 delivered via an LMA (n = 75), both after a @entity2614 / @entity3727 / @entity26 induction. Adverse airway events, as well as hemodynamic, respiratory, and other physiologic responses were recorded during the magnetic resonance imaging scans and in the postanesthesia care unit by a single research nurse who was blind to the treatments. All parents were contacted postoperatively to complete a postanesthetic follow-up. RESULTS:: All 150 @entity1 completed their scans. The frequency of all adverse airway events during emergence and recovery after @entity1875 (12%) was significantly less than that after @entity5161 / @entity3727 /LMA (49%) (95% confidence interval for the risk difference was 23%-50%) (P = 0.0001). Hemodynamic responses and recovery times for the 2 treatments were similar. Early recovery, defined as the time interval from admission to the postanesthesia care unit until eye opening and wakefulness (modified Aldrete score >5), after @entity1875 was more rapid than that after @entity5161 / @entity3727 /LMA (P = 0.0001 and P = 0.0012, respectively). No scans had to be repeated. CONCLUSIONS:: The frequency of adverse airway events during emergence and recovery after @entity1875 infusion with @entity26 by nasal cannula is less than with @entity5161 / @entity3727 /LMA in @entity1 .

title: XXXX Anesthesia for @entity1 Undergoing Magnetic Resonance Imaging: A Comparison with @entity5161 , @entity3810 , and a Laryngeal Mask Airway.

answer: @entity1875 :: (MESH:D015742,Chemical) :: ['Propofol']


abstract: BACKGROUND:: Both @entity1875 infusions with @entity26 delivered through nasal cannula and @entity5161 / @entity3727 ( @entity3810 ) delivered via a laryngeal mask airway (LMA) are used to provide anesthesia for @entity1 undergoing magnetic resonance imaging scans. We compared the incidence of adverse events and perioperative physiologic responses in @entity1 anesthetized with these 2 regimens. METHODS:: One hundred-fifty healthy @entity1 , ages 1 to 10 years, were randomized to receive either a @entity1875 infusion (starting at 300   g kg  min) with @entity26 via nasal cannula (n = 75) or @entity5161 with 70% @entity3727 in @entity26 delivered via an LMA (n = 75), both after a @entity2614 / @entity3727 / @entity26 induction. Adverse airway events, as well as hemodynamic, respiratory, and other physiologic responses were recorded during the magnetic resonance imaging scans and in the postanesthesia care unit by a single research nurse who was blind to the treatments. All parents were contacted postoperatively to complete a postanesthetic follow-up. RESULTS:: All 150 @entity1 completed their scans. The frequency of all adverse airway events during emergence and recovery after @entity1875 (12%) was significantly less than that after @entity5161 / @entity3727 /LMA (49%) (95% confidence interval for the risk difference was 23%-50%) (P = 0.0001). Hemodynamic responses and recovery times for the 2 treatments were similar. Early recovery, defined as the time interval from admission to the postanesthesia care unit until eye opening and wakefulness (modified Aldrete score >5), after @entity1875 was more rapid than that after @entity5161 / @entity3727 /LMA (P = 0.0001 and P = 0.0012, respectively). No scans had to be repeated. CONCLUSIONS:: The frequency of adverse airway events during emergence and recovery after @entity1875 infusion with @entity26 by nasal cannula is less than with @entity5161 / @entity3727 /LMA in @entity1 .

title: @entity1875 Anesthesia for XXXX Undergoing Magnetic Resonance Imaging: A Comparison with @entity5161 , @entity3810 , and a Laryngeal Mask Airway.

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: BACKGROUND: Hepato-renal function is a valuable predictor of success after left ventricular assist device therapy and heart transplantation. Hence, we analyzed the importance of the Model for End-stage @entity409 excluding international normalized ratio (MELD-XI) score to outcomes after heart transplant. METHODS: Adults undergoing heart transplant from the United Network for Organ Sharing (UNOS) database were identified (1994 to 2014). Individual MELD-XI scores were calculated; @entity1 were stratified by MELD-XI quartiles (Q1 to Q4). Multivariate logistic regression and the Cox proportional hazard model were implemented to determine any association between MELD-XI scores, survival and other outcomes. RESULTS: From 39,711 @entity1 undergoing OHT during the study period, MELD-XI score [median 10.7 (interquartile range 7.0 to 14.4)] was calculated for 36,005 @entity1 (76% male and 75% white, 34% Status 1A). Higher MELD-XI scores had higher rates of pre-transplant extracorporeal membrane oxygenation, intra-aortic balloon pump, inotrope use and mechanical ventilation (p < 0.001 for all). Adjusted long-term mortality (median follow-up 8.1 years) was associated with MELD-XI score (hazard ratio [HR] 1.021 [1.016 to 1.026], p < 0.001). The highest MELD-XI quartile was associated with an HR 1.364 [1.255 to 1.482] risk of mortality compared with Q1. MELD-XI score was also associated with @entity8 (adjusted HR Q4 vs Q1: 1.364 [1.153 to 1.614], p < 0.001), @entity64 (adjusted HR Q4 vs Q1: 1.410 [1.074 to 1.852], p = 0.013), dialysis (adjusted HR Q4 vs Q1: 3.982 [3.386 to 4.683], p < 0.001), rejection (adjusted HR Q4 vs Q1: 1.519 [1.286 to 1.795], p = 0.003) and prolonged hospitalization (adjusted HR Q4 vs Q1: 1.635 [1.429 to 1.871], p < 0.001). CONCLUSION: @entity8 , measured with MELD-XI score, predicts morbidity and mortality in @entity1 undergoing orthotopic heart transplantation. @entity8 should be sought and treated before heart transplantation.

title: Model for end-stage XXXX excluding international normalized ratio (MELD-XI) score predicts heart transplant outcomes: Evidence from the registry of the united network for organ sharing.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Hepato-renal dysfunction', 'Etiology of hepato-renal dysfunction', 'increased post-transplant infections']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['Liver Disease']

answer: @entity409 :: (MESH:D008107,Disease) :: ['liver disease']


abstract: UNASSIGNED: @entity170 is a @entity79 that commonly results in a 30% incidence of @entity174 in hens used to produce eggs for @entity1 consumption. One of the causes of @entity170 is the lack of mechanical strain placed on weight-bearing bones. In conventionally-caged hens, there is inadequate space for @entity1573 to exercise and induce mechanical strain on their bones. One approach is to encourage mechanical stress on bones by the addition of perches to conventional cages. Our study focuses on the molecular mechanism of bone remodeling in end-of-lay hens (71 weeks) with access to perches. We examined bone-specific transcripts that are actively involved during development and remodeling. Using real-time quantitative PCR, we examined seven transcripts ( @entity9723 ), @entity39961 ( @entity39961 ), @entity39960 ( @entity39960 ), @entity46200 ( @entity46200 ), @entity71917 ( @entity71917 ), @entity71918 ( @entity71918 ), and @entity8377 (Sry-related high mobility group box)) in phalange, tibia and femur. Our results indicate that the only significant effect was a difference among bones for @entity9723 (femur > phalange). Therefore, we conclude that access to a perch did not alter transcript expression. Furthermore, because hens have been used as a model for @entity1 bone metabolism and @entity170 , the results indicate that bone remodeling due to mechanical loading in @entity1573 may be a product of different pathways than those involved in the @entity1 model.

title: Bone-Remodeling Transcript Levels Are Independent of Perching in End-of-Lay White Leghorn XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian', 'human']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['Osteoporosis', 'osteoporosis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone disease']

entities_list: @entity39961 :: ('428067(Tax:9031)', 'Gene') :: ['receptor activator of nuclear factor kappa-B ligand', 'RANKL']

answer: @entity1573 :: (9031,Species) :: ['Chickens']


abstract: UNASSIGNED: Treatment of @entity15198 is still controversial. We reviewed retrospectively 19 @entity1 with @entity15198 (two bilateral, 21cases) who underwent surgery to the radius and ulna to improve range of motion, decrease @entity158 and improve appearance of the wrist. Nineteen @entity1 underwent 21distal radial osteotomy procedures using three different techniques: subtraction, addition or dome osteotomy. Ulnar shortening and redirection of the distal ulna was performed in 12cases; a long oblique osteotomy was used in 10 of these cases. The Sauv  -Kapandji technique was performed in five cases, an ulnar distal epiphysiodesis in two cases and a combination of osteotomy and epiphysiodesis in one case. The aim was to reduce the distal radial slope and to restore the orientation and congruity of the distal radio-ulnar joint and to improve its function. @entity158 was reduced as a result of the procedure: more than 75% of the cases had no or intermittent @entity158 at the review. Pronation improved from 63   to 68   (P=0.467, not significant) and supination improved from 48   to 72   on average (P=0.034, significant). Grip strength increased from 11 to 18kgf (P=0.013, significant). @entity15198 is not always a benign condition and it responds well to corrective osteotomies.

title: Treatment of XXXX .

entities_list: @entity15198 :: ('MESH:C562398', 'Disease') :: ["Madelung's deformity"]

answer: @entity15198 :: (MESH:C562398,Disease) :: ['Madelung's deformity']


abstract: UNASSIGNED: Study Design Clinical measurement, cross-sectional. Objective To determine if spinal joint @entity2693 is different in individuals with non-specific @entity4048 , and whether @entity2693 magnitude is associated with @entity158 intensity and disability. Background Manual therapists commonly evaluate spinal joint @entity2693 in @entity1 presenting with non-specific @entity4048 . However, a relationship between @entity2693 and @entity4048 has not yet been demonstrated. Methods Spinal @entity2693 at C7 was objectively measured in @entity1 with chronic non-specific @entity4048 whose symptomatic spinal level was identified as C7 (n= 12), and age and gender matched asymptomatic controls (n = 12). @entity2693 (slope of the linear region of the force-displacement curve) was quantified using a device applying 5 standardized mechanical force cycles to the C7 spinous process while concurrently measuring displacement and resistance to movement. @entity2693 was compared between groups using an independent t-test. Spearman's rho and Pearson's r were used to determine the extent @entity2693 magnitude was associated with @entity158 intensity (visual analogue scale) and level of disability (Neck Disability Index) respectively, in the group with @entity4048 . Results @entity1 with non-specific @entity4048 had greater spinal joint @entity2693 at C7 compared with asymptomatic individuals (mean difference 1.78 N/mm, 95% CI 0.28, 3.27, P = .022). However, @entity2693 magnitude in the group with @entity4048 was not associated (P>.05) with @entity158 intensity or level of disability. Conclusion These preliminary results suggest that cervical @entity3570 may be greater in the presence of non-specific @entity4048 . However, judgements regarding @entity158 intensity and level of disability should not be inferred from examinations of spinal joint @entity2693 . J Orthop Sports Phys Ther, Epub 27 Jan 2015. doi:10.2519/jospt.2015.5711.

title: Comparison of Cervical @entity3570 in Individuals With XXXX and an Asymptomatic Comparison Group.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity3570 :: ('MESH:D016135', 'Disease') :: ['spine stiffness']

entities_list: @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness', 'Stiffness']

answer: @entity4048 :: (MESH:D019547,Disease) :: ['Chronic Nonspecific Neck Pain']


abstract: UNASSIGNED: Study Design Clinical measurement, cross-sectional. Objective To determine if spinal joint @entity2693 is different in individuals with non-specific @entity4048 , and whether @entity2693 magnitude is associated with @entity158 intensity and disability. Background Manual therapists commonly evaluate spinal joint @entity2693 in @entity1 presenting with non-specific @entity4048 . However, a relationship between @entity2693 and @entity4048 has not yet been demonstrated. Methods Spinal @entity2693 at C7 was objectively measured in @entity1 with chronic non-specific @entity4048 whose symptomatic spinal level was identified as C7 (n= 12), and age and gender matched asymptomatic controls (n = 12). @entity2693 (slope of the linear region of the force-displacement curve) was quantified using a device applying 5 standardized mechanical force cycles to the C7 spinous process while concurrently measuring displacement and resistance to movement. @entity2693 was compared between groups using an independent t-test. Spearman's rho and Pearson's r were used to determine the extent @entity2693 magnitude was associated with @entity158 intensity (visual analogue scale) and level of disability (Neck Disability Index) respectively, in the group with @entity4048 . Results @entity1 with non-specific @entity4048 had greater spinal joint @entity2693 at C7 compared with asymptomatic individuals (mean difference 1.78 N/mm, 95% CI 0.28, 3.27, P = .022). However, @entity2693 magnitude in the group with @entity4048 was not associated (P>.05) with @entity158 intensity or level of disability. Conclusion These preliminary results suggest that cervical @entity3570 may be greater in the presence of non-specific @entity4048 . However, judgements regarding @entity158 intensity and level of disability should not be inferred from examinations of spinal joint @entity2693 . J Orthop Sports Phys Ther, Epub 27 Jan 2015. doi:10.2519/jospt.2015.5711.

title: Comparison of Cervical XXXX in Individuals With @entity4048 and an Asymptomatic Comparison Group.

answer: @entity3570 :: (MESH:D016135,Disease) :: ['Spine Stiffness']


abstract: PURPOSE: To evaluate the influence of the cyclosporine in liver regeneration in @entity35 submitted to an experimental model of 70% hepatectomy. METHODS: Forty male @entity35 were randomly divided in four subgroups (C.24h, C.7d, E.24h, E.7d), according to the drug used and the day of sacrifice (24 hours and 7 days). Cyclosporine (10mg/Kg/day) was given to the study subgroup and 1 ml of 0.9% sodium chloride was to the control subgroup. Resection of left lateral lobe and median lobe performing 70% of @entity409 . During the animals' @entity204 , KWON formula was applied. Counting of mitotic figures and percentage of positive nucleus with PCNA and Ki-67 were evaluated. RESULTS: In the 2nd, 4th PO and @entity204 days, E.7d lose more weight than C.7d. Regarding to the KWON formula, the C.7d regenerated more than the C.24h and the same with the E.7d. Comparing between the groups, only E7d subgroup was statistically significant compared with C.7d, showing the stimulating effect of cyclosporine in liver regeneration. Immunohistochemestry had significant results between the study subgroups. The mitotic index revealed statistical differences in the control subgroups. CONCLUSION: Cyclosporine, in spite of being an immunosuppressive drug, has a positive effect in liver regeneration, although reduce the animal's body weight.

title: Effect of cyclosporine on liver regeneration in partial hepatectomized XXXX .

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver mass']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: The fine structural features of microcirculation in benign @entity11 , as compared to those in @entity463 have insufficiently been studied. 36 @entity816 and @entity816 (grades I and II) were examined with the electron microscope in order to classify the arterioles, capillaries and venules of these @entity5 . In all the @entity11 , the number of arterioles was smaller than in the normal brain parenchyma. A thickening of the subendothelial basement membrane could be assessed regularly. In the architecture of the small vessels numerous transitional forms could be found in many cases. On this basis the designation "capillary-like" and "venule-like" vessels seems to be justified. As a rule, the venule-like vessels are more numerous than the capillaries. The pericapillary and particularly the perivenular spaces are frequently dilated. In a few areas no continuous perivascular sheath of astrocytic foot processes are formed. At places glial processes can be found in the perivascular spaces which are not covered by a basement membrane. Lack of arterioles can lead to disturbances in autoregulation, and the frequently pathological structure of the capillaries and venules can result in disordered transport of water and ions with consecutive @entity4 .

title: [Ultrastructural systematization of vascular changes in XXXX ].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['gliomas']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['oligoastrocytomas', 'astrocytomas']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas']

answer: @entity11 :: (MESH:D005910,Disease) :: ['gliomas']


abstract: BACKGROUND: A sensitive and reproducible Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry method has been developed for the simultaneous quantification of the 29 commonly prescribed @entity1245 and z-drugs in hair. The method was validated according to international guidelines. METHODS: After decontamination (with @entity1044 and water), compounds were extracted from 20 mg of pulverized hair samples using @entity1042 at 45  C and sonication for 2 hours. The drugs were recovered by liquid-liquid extraction using @entity42111 , evaporated to dryness, and reconstituted with 100  L of @entity1042 before injection in the UPLC-MS/MS. RESULTS: The applied gradient ensured the elution of all the compounds within 7 minutes using 0.1% @entity5189 in water and @entity1042 as mobile phase. The lower limit of quantification values ranged from 0.5 to 5 pg/mg of hair. Calibration curves were linear for almost all the compounds and ranged from the limit of quantification to 620 pg/mg hair. The bias and relative standard deviation of the intraday and interday imprecision were lower than 15% in 3 fortified "in-house" quality control samples, 1 external quality control sample, and 1 authentic hair sample (from a @entity3175 user). No significant matrix effects were observed for most of the compounds, and the extraction efficiency of the sample cleanup procedure ranged from 19% to 82% with a relative standard deviation <15% [except for clobazam (16%), @entity68629 (20%), @entity11465 (18%), and @entity71919 (20%)]. The method was then successfully applied to the analysis of 40 hair samples from the workplace drug testing, containing @entity1401 , @entity17133 , @entity2053 , @entity3175 , @entity2492 , and @entity71920 (and metabolites). CONCLUSIONS: The method was completely validated and can be of interest to clinical and forensic laboratories.

title: Detection of XXXX and z-Drugs in Hair Using an UHPLC-MS/MS Validated Method: Application to Workplace Drug Testing.

entities_list: @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam']

entities_list: @entity42111 :: ('MESH:C006854', 'Chemical') :: ['1-chlorobutane']

entities_list: @entity1044 :: ('MESH:D008752', 'Chemical') :: ['dichloromethane']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity71920 :: ('MESH:C033473', 'Chemical') :: ['desalkylflurazepam']

entities_list: @entity68629 :: ('MESH:C020168', 'Chemical') :: ['loprazolam']

entities_list: @entity17133 :: ('MESH:D004949', 'Chemical') :: ['estazolam']

entities_list: @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepines']

entities_list: @entity1401 :: ('MESH:D000525', 'Chemical') :: ['alprazolam']

entities_list: @entity11465 :: ('MESH:C020960', 'Chemical') :: ['brotizolam']

entities_list: @entity71919 :: ('MESH:C020860', 'Chemical') :: ['7-aminoclonazepam']

entities_list: @entity2053 :: ('MESH:D002998', 'Chemical') :: ['clonazepam']

entities_list: @entity5189 :: ('MESH:C030544', 'Chemical') :: ['formic acid']

entities_list: @entity2492 :: ('MESH:C049109', 'Chemical') :: ['zolpidem']

answer: @entity1245 :: (MESH:D001569,Chemical) :: ['Benzodiazepines']


abstract: INTRODUCTION: The effects of nanoparticles on pregnancy remain unclear. In this study, we investigate whether nanoparticles of a specific size can cross the placenta and affect trophoblast function. METHODS: Fluorescently labelled @entity3338 -modified @entity852 beads with diameters of 20, 40, 100, 200, and 500 nm were chosen as model particles. In vitro, trophoblast cell line (3A-Sub-E) or primary culture of term trophoblasts was used for nanoparticle uptake analysis using flow cytometry, confocal microscopy, @entity1603 proliferation assay and analysis of cell apoptosis using Western blot. Intravenous injection of nanoparticles into pregnant @entity19 at embryonic day 17 was used to study whether nanoparticles can cross the placenta. The @entity19 placentas were collected and quantitatively analyzed using high-performance liquid chromatography for nanoparticle uptake. RESULTS: Fluorescent @entity852 particles with diameters of up to 500 nm were taken up by the placenta and were able to cross the placental barrier. The fluorescent @entity852 particles were observed in various organs of fetuses after 4 h of administration to pregnant @entity19 . The nanoparticle uptake by placental tissue was significantly increased in nanoparticles with a diameter of 40 nm. No linear association was evident between nanoparticle size and uptake. Nanoparticles with diameters of 20 nm (200  g/ml) and 40 nm (500  g/ml) could induce trophoblast cell apoptosis with increased cleaved caspase 3 and reduced cell proliferation. DISCUSSION: Our findings suggest that nanoparticles can cross the placenta and be taken up by fetal organs. Certain concentrations of @entity3338 -modified @entity852 nanoparticles may be cytotoxic to trophoblasts, which could alter placental function.

title: Nanoparticles can cross XXXX placenta and induce trophoblast apoptosis.

entities_list: @entity852 :: ('MESH:D011137', 'Chemical') :: ['polystyrene']

entities_list: @entity3338 :: ('CHEBI:35757', 'Chemical') :: ['carboxylate']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: UNASSIGNED: This study investigates the mechanical properties and in vitro @entity137 of one- and two-dimensional @entity8240 nanomaterials-reinforced biodegradable polymeric nanocomposites. @entity49474 ( @entity2848 ) nanocomposites were fabricated using crosslinking agent @entity71921 and inorganic nanomaterials: @entity8240 nanotubes (BNNTs) and @entity8240 nanoplatelets (BNNPs) dispersed at 0.2 wt % in the polymeric matrix. The incorporation of BNNPs and BNNTs resulted in a    38 and    15% increase in compressive (Young's) modulus, and    31 and    6% increase in compressive yield strength compared to @entity2848 control, respectively. The nanocomposites showed a time-dependent increased protein adsorption for collagen I protein. The @entity137 evaluation of aqueous BNNT and BNNP dispersions (at 1-100  g/mL concentrations) using @entity19 MC3T3 preosteoblast cells showed    73-99% viability. The @entity137 evaluation of media extracts of nanocomposites before crosslinking, after crosslinking, and upon degradation (using 1*-100* dilutions) showed dose-dependent @entity137 responses. Crosslinked nanocomposites showed excellent (   79-100%) cell viability, cellular attachment (   57-67%), and spreading similar to cells grown on the surface of tissue culture @entity852 control. The media extracts of degradation products showed a dose-dependent @entity137 . The favorable cytocompatibility results in combination with improved mechanical properties of BNNT and BNNP nanocomposites opens new avenues for further in vitro and in vivo safety and efficacy studies towards bone tissue engineering applications.    2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2015.

title: XXXX nanotubes and nanoplatelets as reinforcing agents of polymeric matrices for bone tissue engineering.

entities_list: @entity8240 :: ('MESH:C017282', 'Chemical') :: ['boron nitride']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity49474 :: ('MESH:C097850', 'Chemical') :: ['Poly(propylene fumarate)']

entities_list: @entity71921 :: ('MESH:C042670', 'Chemical') :: ['N-vinyl pyrrolidone']

answer: @entity8240 :: (MESH:C017282,Chemical) :: ['Boron nitride']


abstract: UNASSIGNED: In drug-resistant @entity1315 ( @entity1315 ), MRI studies have shown consistent mesiotemporal and neocortical structural alterations when comparing @entity1 to healthy controls. It remains, however, relatively unclear whether the side of @entity410 focus differentially impacts the degree of structural damage. This work performed a comprehensive surface-based analysis of mesiotemporal and neocortical morphology on preoperative 1.5 T MRI in 25/35 LTLE/RTLE @entity1 that achieved @entity410 freedom after surgery (i.e., Engel-I outcome; 7        2 years follow-up), an imaging-independent confirmation of focus lateralization. Compared to 46 age- and sex-matched controls, both @entity1315 groups displayed marked @entity194 in mesiotemporal regions, while cortical thinning was bilateral. Direct contrasts between LTLE and RTLE did not reveal significant differences. Bootstrap simulations indicated low reproducibility of observing a between-cohort difference; power analysis revealed that more than 110 @entity1 would be necessary to detect subtle differences. No difference between LTLE and RTLE was confirmed when using voxel-based morphometry, an independent proxy of gray matter volume. Similar results were obtained analyzing a separate 3 T dataset (15/15 LTLE/RTLE @entity1 ; Engel-I after 4        2 years follow-up; 42 controls). Our results strongly support equivalent gray matter compromise in left and right @entity1315 . The morphological profile of @entity410 -free @entity1 , presenting with ipsilateral mesiotemporal and bilateral cortical @entity194 , motivates the development of neuromarkers of outcome that consider both mesiotemporal and neocortical structures. Hum Brain Mapp, 2015.    2015 Wiley Periodicals, Inc.

title: Gray matter structural compromise is equally distributed in left and right XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1315 :: ('MESH:D004833', 'Disease') :: ['TLE', 'temporal lobe epilepsy']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy', 'ipsilateral atrophy']

answer: @entity1315 :: (MESH:D004833,Disease) :: ['temporal lobe epilepsy']


abstract: BACKGROUND: @entity927 ( @entity24451 ) is a novel therapeutic agent for hyperpigmented @entity272 . The efficacy and safety of topical @entity24451 in @entity1 with @entity1709 has not been heretofore studied. The main objective of this study is to evaluate the efficacy and safety of topical @entity24451 combined with intense pulsed light (IPL) treatment in Asians with @entity1709 . METHODS: A randomized, split-face (internally controlled) study was conducted in 15 @entity1 who received four monthly sessions of IPL to both sides of the face. Topical @entity24451 or vehicle was applied to a randomly assigned side during and after IPL treatment. @entity1 were followed up for 12 weeks after completing the IPL treatments. Baseline and follow-up @entity894 ( @entity894 ; measured by Mexameter  , Courage and Khazaka, Cologne, Germany) and modified @entity1709 area and severity index (mMASI) scores were determined. RESULTS: Thirteen subjects completed the study without serious adverse events. @entity894 and mMASI decreased significantly from baseline to 12 weeks after the last IPL treatment on the topical @entity24451 side but not on the vehicle side. The efficacy of topical @entity24451 in preventing rebound pigmentation after IPL treatment was also statistically significant. CONCLUSION: Topical @entity24451 can be considered an effective and safe adjuvant to conventional treatment for @entity1709 .

title: Topical @entity927 as an adjuvant treatment in XXXX : Side-by-side comparison clinical study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity894 :: ('MESH:C566784', 'Disease') :: ['MI', 'melanin index']

entities_list: @entity927 :: ('MESH:D014148', 'Chemical') :: ['Tranexamic acid']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disorders']

answer: @entity1709 :: (MESH:D008548,Disease) :: ['melasma']


abstract: BACKGROUND: @entity927 ( @entity24451 ) is a novel therapeutic agent for hyperpigmented @entity272 . The efficacy and safety of topical @entity24451 in @entity1 with @entity1709 has not been heretofore studied. The main objective of this study is to evaluate the efficacy and safety of topical @entity24451 combined with intense pulsed light (IPL) treatment in Asians with @entity1709 . METHODS: A randomized, split-face (internally controlled) study was conducted in 15 @entity1 who received four monthly sessions of IPL to both sides of the face. Topical @entity24451 or vehicle was applied to a randomly assigned side during and after IPL treatment. @entity1 were followed up for 12 weeks after completing the IPL treatments. Baseline and follow-up @entity894 ( @entity894 ; measured by Mexameter  , Courage and Khazaka, Cologne, Germany) and modified @entity1709 area and severity index (mMASI) scores were determined. RESULTS: Thirteen subjects completed the study without serious adverse events. @entity894 and mMASI decreased significantly from baseline to 12 weeks after the last IPL treatment on the topical @entity24451 side but not on the vehicle side. The efficacy of topical @entity24451 in preventing rebound pigmentation after IPL treatment was also statistically significant. CONCLUSION: Topical @entity24451 can be considered an effective and safe adjuvant to conventional treatment for @entity1709 .

title: Topical XXXX as an adjuvant treatment in @entity1709 : Side-by-side comparison clinical study.

answer: @entity927 :: (MESH:D014148,Chemical) :: ['tranexamic acid']


abstract: While reactive @entity26 species (ROS) play a role in muscle repair, excessive amounts of ROS for extended periods may lead to oxidative stress. Antioxidants, as @entity4025 (RS), may reduce oxidative stress, restore mitochondrial function and promote myogenesis and @entity1184 . However, RS dose-effectiveness for muscle plasticity is unclear. Therefore, we investigated RS dose-response on C2C12 myoblast and myotube plasticity 1. in the presence and 2. absence of different degrees of oxidative stress. Low RS concentration (10    M) stimulated myoblast cell cycle arrest, @entity4222 and sprouting, which were inhibited by higher doses (40-60    M). RS did not increase oxidative capacity. In contrast, RS induced mitochondria loss, reduced cell viability and ROS production, and activated stress response pathways [Hsp70 and pSer36- @entity19490 ( @entity9703 ) proteins]. However, the deleterious effects of @entity274 (1000     M) on cell @entity4222 were alleviated after preconditioning with 10     M-RS. This dose also enhanced cell motility mediated by 100     M- @entity274 , while higher RS-doses augmented the @entity274 -induced impaired myoblast regeneration and mitochondrial dehydrogenase activity. In conclusion, low @entity4025 doses promoted in vitro muscle regeneration and attenuated the impact of ROS, while high doses augmented the reduced plasticity and metabolism induced by oxidative stress. Thus, the effects of @entity4025 depend on its dose and degree of oxidative stress.

title: The impact of XXXX and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction.

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity4222 :: ('MESH:D014085', 'Disease') :: ['migration']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol']

answer: @entity4025 :: (MESH:C059514,Chemical) :: ['resveratrol']


abstract: UNASSIGNED: The study aimed to evaluate the prognostic significance of prechemotherapy neutrophil to lymphocyte ratio and platelet to lymphocyte ratio, and preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in locally @entity1544 . We analyzed retrospectively locally @entity1544 @entity1 who had received neoadjuvant chemotherapy before undergoing a radical esophagectomy between 2009 and 2012. Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio before chemotherapy and before the surgery were calculated. Univariate analyses showed that prechemotherapy neutrophil to lymphocyte ratio >5 (P = 0.048, hazard ratio = 2.86; 95% confidence interval: 1.01-8.12) and prechemotherapy platelet to lymphocyte ratio >130 (P = 0.025, hazard ratio = 5.50; 95% confidence interval: 1.23-24.55) were associated significantly with @entity1349 ( @entity1349 ), and prechemotherapy platelet to lymphocyte ratio >130 (P = 0.026, hazard ratio = 3.18; 95% confidence interval: 1.15-8.85) was associated significantly with progression-free survival. However, only prechemotherapy neutrophil to lymphocyte ratio >5 (P = 0.024, hazard ratio = 3.50; 95% confidence interval: 1.18-10.40) remained significantly associated with @entity1349 in multivariate analyses. Neither preoperative neutrophil to lymphocyte ratio nor platelet to lymphocyte ratio was associated with @entity1349 or progression-free survival. The prechemotherapy neutrophil to lymphocyte ratio >5 to preoperative neutrophil to lymphocyte ratio  <=5 group showed significantly worse @entity1349 than the prechemotherapy neutrophil to lymphocyte ratio  <=5 to preoperative neutrophil to lymphocyte ratio  <=5 group (P = 0.050). The prechemotherapy platelet to lymphocyte ratio >130 to preoperative platelet to lymphocyte ratio  <=130 group (P = 0.016) and platelet to lymphocyte ratio >130 to preoperative platelet to lymphocyte ratio >130 group (P = 0.042) showed significantly worse @entity1349 than the prechemotherapy platelet to lymphocyte ratio  <=30 to preoperative platelet to lymphocyte ratio  <=130 group. In conclusions, prechemotherapy neutrophil to lymphocyte ratio is an independent prognostic factor for @entity1349 in @entity1 with @entity1544 treated with neoadjuvant chemotherapy, and, as an adverse prognostic predictor, increased prechemotherapy neutrophil to lymphocyte ratio is superior to platelet to lymphocyte ratio. Maintaining a low neutrophil to lymphocyte ratio and platelet to lymphocyte ratio throughout treatment is a predictor of better @entity1349 .

title: Prechemotherapy neutrophil   :   lymphocyte ratio is superior to the platelet   :   lymphocyte ratio as a prognostic indicator for locally XXXX treated with neoadjuvant chemotherapy.

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['advanced esophageal squamous cell cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['overall survival', 'OS']

answer: @entity1544 :: (MESH:D018307,Disease) :: ['advanced esophageal squamous cell cancer']


abstract: UNASSIGNED: With the exception of @entity2204 , genome-wide association studies have failed to identify strong genetic risk factors for late-onset @entity195 , despite strong evidence of heritability, suggesting that many low penetrance genes may be involved. Additionally, the nature of the identified genetic risk factors and their relation to disease pathology is also largely obscure. Previous studies have found that a @entity5 -associated variant of the cell cycle inhibitor gene @entity994 is associated with increased risk of @entity195 . The aim of this study was to confirm this association and to elucidate the effects of the variant on protein function and Alzheimer-type pathology. We examined the association of the @entity994 variant with @entity195 and @entity191 with @entity303 . The genotyping studies were performed on 719 @entity1 of the Oxford Project to Investigate Memory and Ageing, 225 @entity1 of a @entity191 DNA bank, and 477 @entity1 of the @entity1 Random Control collection available from the European Collection of Cell Cultures. The post mortem studies were carried out on 190 @entity1 . In the in-vitro study, @entity1 @entity8 were transfected with either the common or rare @entity994 variant; and cytometry was used to assess cell cycle kinetics, @entity994 protein expression and sub-cellular localisation. The variant was associated with an increased risk of @entity195 , and @entity191 with @entity303 , relative to age matched controls. Furthermore, the variant was associated with an earlier age of onset of @entity195 , and a more severe phenotype, with a primary influence on the accumulation of tangle pathology. In the in-vitro study, we found that the SNPs reduced the cell cycle inhibitory and anti-apoptotic activity of @entity994 . The results suggest that the @entity5 -associated variant of @entity994 may contribute to the loss of cell cycle control in neurons that may lead to @entity179 .

title: The Effects of Two Polymorphisms on XXXX Function and Their Association with @entity195 in a Population of European Descent.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'human', 'Human']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['embryonic kidney cells']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['Alzheimer-type neurodegeneration']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"]

answer: @entity994 :: (1026,Gene) :: ['p21cip1']


abstract: UNASSIGNED: With the exception of @entity2204 , genome-wide association studies have failed to identify strong genetic risk factors for late-onset @entity195 , despite strong evidence of heritability, suggesting that many low penetrance genes may be involved. Additionally, the nature of the identified genetic risk factors and their relation to disease pathology is also largely obscure. Previous studies have found that a @entity5 -associated variant of the cell cycle inhibitor gene @entity994 is associated with increased risk of @entity195 . The aim of this study was to confirm this association and to elucidate the effects of the variant on protein function and Alzheimer-type pathology. We examined the association of the @entity994 variant with @entity195 and @entity191 with @entity303 . The genotyping studies were performed on 719 @entity1 of the Oxford Project to Investigate Memory and Ageing, 225 @entity1 of a @entity191 DNA bank, and 477 @entity1 of the @entity1 Random Control collection available from the European Collection of Cell Cultures. The post mortem studies were carried out on 190 @entity1 . In the in-vitro study, @entity1 @entity8 were transfected with either the common or rare @entity994 variant; and cytometry was used to assess cell cycle kinetics, @entity994 protein expression and sub-cellular localisation. The variant was associated with an increased risk of @entity195 , and @entity191 with @entity303 , relative to age matched controls. Furthermore, the variant was associated with an earlier age of onset of @entity195 , and a more severe phenotype, with a primary influence on the accumulation of tangle pathology. In the in-vitro study, we found that the SNPs reduced the cell cycle inhibitory and anti-apoptotic activity of @entity994 . The results suggest that the @entity5 -associated variant of @entity994 may contribute to the loss of cell cycle control in neurons that may lead to @entity179 .

title: The Effects of Two Polymorphisms on @entity994 Function and Their Association with XXXX in a Population of European Descent.

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']


abstract: Alternative splicing is a fundamental process of gene regulation that contributes to protein diversity, a common phenomenon in the @entity1 genome. Alternative splicing events not only happen in the normal gene regulation process, but are also closely related to certain diseases, including @entity5 . In this review, we briefly demonstrate the proof of concept (POC) of the relationship between alternative splicing and DNA damage, and describe the associations among alternative splicing and @entity5 pathogenesis, DNA damage, and @entity1820 . We discuss whether alternative splicing leads to genetic instability, which is considered to be a driving force for tumorigenesis. @entity71922 is a c-myc transcriptional suppressor. A splice variant of FIR that lacks exon 2 in the transcriptional repressor domain ( @entity71922 exon2), upregulates c-myc transcription by inactivating wild-type FIR. FIR+/- m @entity19 exhibited marked c-myc mRNA upregulation, particularly in the peripheral blood (PB), without any significant pathogenic phenotype. Because the single knockout of T @entity186 generates t @entity6732 FIR+/-T @entity186 /- m @entity19 developed T @entity11511 (T @entity981 with increased organ or bone marrow invasion and showed a poor prognosis. After describing the POC of alternative splicing of FIR in DNA damage and c @entity105 clinical application for c @entity5 diagnosis and treatment by FIR/F @entity71922 exon2 was briefly summarized. Chiba University has prepared a biobank to support studies to develop biomarker detection, molecular diagnosis, and "Omics" research. In conclusion, alternative splicing of FIR, generating FI @entity71922 xon2, potentially contributes to not only colorectal car @entity105 ut also leukemogenesis, and a better understanding of the role and mechanism of alternative splicing in tumorigenesis may reveal new directions for can @entity5 omarker detection.

title: [Alternative Splicing Detection as Biomarker Candidates for XXXX Diagnosis and Treatment with Establishment of Clinical Biobank in Chiba University].

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancers']

entities_list: @entity6732 :: ('MESH:D013953', 'Disease') :: ['thymic lymphoma']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

entities_list: @entity11511 :: ('MESH:D054218', 'Disease') :: ['T-cell type acute lymphocytic/lymphoblastic leukemia']

entities_list: @entity71922 :: ('67959(Tax:10090)', 'Gene') :: ['FUSE-binding protein (FBP) -interacting repressor (FIR)', 'FIR']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: OBJECTIVE:: Adverse early life events are key factors for development of @entity344 ( @entity344 ). @entity293 ( @entity293 ) is associated with chronic @entity2371 in adults, a finding that has been recapitulated in @entity19 models, but the relation between @entity490 has not been studied in @entity1 . We hypothesized that @entity293 in infancy increases the risk of @entity344 and @entity490 ( @entity490 ) in childhood. METHODS:: The present study included @entity1 , ages 4 to 18 years, with a single @entity293 in the first year of life and their siblings with no history of @entity293 . Parents completed the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-III) by telephone. @entity1 meeting QPGS-III criteria for @entity344 but with @entity158 less than once weekly were considered to have @entity490 . RESULTS:: A total of 57 @entity1 with @entity293 and 58 sibling controls were identified. Mean age at @entity293 was 4.8 months, and mean time since @entity293 was 9.3 years. At the time of survey, mean age of @entity1 was 9.7 years (5-16 years, 40% @entity1 ) and that of controls was 9.6 years (range 4-17 years, 57% @entity1 ). @entity344 were diagnosed in 6 of 57 (11%) @entity1 , and 1 of 58 (2%) controls (P=0.06). @entity490 was identified in 10 of 57 (18%) @entity1 and 2 of 58 (3%) controls (P=0.02). Predominant sex (female), infecting organism ( @entity526 ), and treatment (third-generation cephalosporin) were similar in @entity1 with @entity293 with and without @entity490 . CONCLUSIONS:: We show for the first time that @entity293 is associated with @entity490 in childhood. We speculate that pelvic organ sensory convergence explains our findings.

title: XXXX in Infancy Is a Risk Factor for Chronic @entity490 in Childhood.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'boys']

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['FGIDs', 'functional gastrointestinal disorders']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['UTI and chronic pelvic and abdominal pain', 'CAP', 'chronic abdominal pain']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['UTI', 'Urinary tract infection']

answer: @entity293 :: (MESH:D014552,Disease) :: ['Urinary Tract Infection']


abstract: OBJECTIVE:: Adverse early life events are key factors for development of @entity344 ( @entity344 ). @entity293 ( @entity293 ) is associated with chronic @entity2371 in adults, a finding that has been recapitulated in @entity19 models, but the relation between @entity490 has not been studied in @entity1 . We hypothesized that @entity293 in infancy increases the risk of @entity344 and @entity490 ( @entity490 ) in childhood. METHODS:: The present study included @entity1 , ages 4 to 18 years, with a single @entity293 in the first year of life and their siblings with no history of @entity293 . Parents completed the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III Version (QPGS-III) by telephone. @entity1 meeting QPGS-III criteria for @entity344 but with @entity158 less than once weekly were considered to have @entity490 . RESULTS:: A total of 57 @entity1 with @entity293 and 58 sibling controls were identified. Mean age at @entity293 was 4.8 months, and mean time since @entity293 was 9.3 years. At the time of survey, mean age of @entity1 was 9.7 years (5-16 years, 40% @entity1 ) and that of controls was 9.6 years (range 4-17 years, 57% @entity1 ). @entity344 were diagnosed in 6 of 57 (11%) @entity1 , and 1 of 58 (2%) controls (P=0.06). @entity490 was identified in 10 of 57 (18%) @entity1 and 2 of 58 (3%) controls (P=0.02). Predominant sex (female), infecting organism ( @entity526 ), and treatment (third-generation cephalosporin) were similar in @entity1 with @entity293 with and without @entity490 . CONCLUSIONS:: We show for the first time that @entity293 is associated with @entity490 in childhood. We speculate that pelvic organ sensory convergence explains our findings.

title: @entity293 in Infancy Is a Risk Factor for Chronic XXXX in Childhood.

answer: @entity490 :: (MESH:D015746,Disease) :: ['Abdominal Pain']


abstract: BACKGROUND: Nature images are frequently used for therapeutic purposes in hospital settings. Nature images may distract @entity1 from @entity158 and promote psychological and physiological well-being, yet limited research is available to guide the selection process of nature images. OBJECTIVE: The hypothesis is that higher degrees of presence and/or influence in the still photograph make it more effective at holding the viewer's attention, which therefore may distract the viewer from @entity158 , and therefore be considered therapeutic. Research questions include: (1) Is there a significant difference in the level of perceived presence among the selected images? (2) Is there a significant difference in the level of perceived influence among the selected images? (3) Is there a correlation between levels of presence and levels of influence? METHODS: 109 college students were randomly assigned to one of four different image categories defined by Appleton's prospect refuge theory of landscape preference. Categories included prospect, refuge, hazard, and mixed prospect and refuge. A control group was also included. Each investigation was divided into five periods: prereporting, rest, a @entity158 stressor (hand in ice water for up to 120 seconds), recovery, and postreporting. Physiological readings (vital signs) were measured repeatedly using a Dinamap automatic vital sign tracking machine. Psychological responses (mood) to the image were collected using a reliable instrument, the Profile of Mood States. RESULTS: No significant statistical difference in levels of presence was found among the four image categories. However, levels of influence differed and the hazard nature image category had significantly higher influence ratings and lower diastolic blood pressure readings during the @entity158 treatment. A correlation (r = .62) between presence and influence was identified; as one rose, so did the other. Mood state was significantly low for the hazard nature image after the @entity158 stressor experience. CONCLUSIONS: Though the hazard image caused distraction from @entity158 , it is nontherapeutic because of the low mood ratings it received. These preliminary findings contribute methodology to the research field and stimulate interest for additional research into the visual effects of nature images on @entity158 .

title: The effects of presence and influence in nature images in a simulated hospital XXXX room.

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: BACKGROUND The results of @entity8 in a large degree on appropriate @entity788 allograft donor selection. Several risk factors of early surgical complications or @entity788 allograft loss following transplantation have been identified, but the final decision on @entity788 harvesting for transplantation belongs to the surgeon. In the present study we aimed to assess whether histopathological examination may be utilized for detection of @entity82 and @entity6574 in tissue from a potential @entity788 allograft. Additionally, we aimed to test whether presence of pancreatic @entity82 and @entity6574 may be explained solely by donor age and/or body mass index (BMI). MATERIAL AND METHODS Pancreata retrieved from 50 deceased organ donors referred to our institution and not transplanted between 2010 and 2013 were used for the present study. Tissue samples were excised from pancreata, fixed in @entity406 , and embedded in @entity982 . Presence and intensity of pancreatic @entity82 and @entity6574 were assessed semi-quantitatively. RESULTS @entity82 was found in the majority of study samples (72%), but it was usually mild or moderate. @entity6574 was present in 34% of the study cases. Presence of @entity82 was more frequent in older donors, but was still not rare in donors under 40 years old. Presence of @entity6574 did not seem to be significantly related to donor age. Neither pancreatic @entity82 nor @entity6574 was related to donor BMI. CONCLUSIONS There is no clear relationship between histological parenchymal changes in potential @entity788 allograft and donor age and BMI. Histopathological assessment of pancreatic @entity82 and/or @entity6574 can potentially facilitate decision making on @entity788 allograft acceptance for solid organ transplantation.

title: Histopathological Examination may be Useful for Assessment of XXXX and Lipomatosis of Pancreas Allograft Prior to Solid Organ Transplantation.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['pancreas transplantation depend']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'Fibrosis']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreas']

entities_list: @entity6574 :: ('MESH:D008068', 'Disease') :: ['Lipomatosis', 'lipomatosis']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

answer: @entity82 :: (MESH:D005355,Disease) :: ['Fibrosis']


abstract: INTRODUCTION: Chronic @entity3540 media, apart from destruction of bones and possibility of otogenous complications, is characterized by possibility of recurrence of the disease after non radical treatment or presence of risk factors. AIM: This paper intends to analyze changes typical for @entity3540 , observed during otosurgery including the results of bacteriological investigations. MATERIAL AND METHODS: Nearly 450 otosurgeries were performed in Department of Otolaryngology at Jagiellonian University 2004-2007. Analysis refers to @entity1 reoperated on chronic @entity3540 media. RESULTS: 47 reoperations in the course of chronic @entity2346 media were performed. Bacteriological analysis was provided in 21 cases. The most common bacteria were @entity794 and @entity796 . Biofilms were not observed in specimens. CONCLUSIONS: The recurrence of the process should be expected in @entity1 with @entity3540 . They require regular, periodical follow-up examination.

title: [Reoperations in XXXX with chronic otitis media cholesteatomatosa].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity3540 :: ('MESH:D002781', 'Disease') :: ['cholesteatoma', 'cholesteatoma otitis']

entities_list: @entity2346 :: ('MESH:D010031', 'Disease') :: ['choleateatoma otitis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND AND PURPOSE: The present study was undertaken to investigate an effect of @entity2781 , a potent arrhythmic blocker of the voltage-gated @entity3529 channel, @entity9493 , on cardiac autonomic control. Combined with effects on ardiomyocytes, these properties could influence its arrhythmic potency. EXPERIMENTAL APPROACH: The short-term variability of beat-to-beat QT interval (STVQT ), induced by @entity2781 is a strong surrogate of @entity1166 . Involvement of autonomic modulation in STVQT was investigated in healthy @entity5434 and @entity235 by power spectral analysis under conditions of autonomic blockade with @entity4033 . KEY RESULTS: Increase in STVQT induced by @entity2781 in monkeys and @entity235 was closely associated with an enhancement of endogenous heart rate and @entity2198 . These effects were fully suppressed under conditions of autonomic blockade with @entity4033 . @entity943 , including @entity1166 in monkeys, were prevented in both species @entity2198 were suppressed by autonomic blockade. Similar enhancements of heart rate @entity2198 were found in @entity235 with other @entity9493 blockers described as causing @entity1166 in @entity1 . CONCLUSIONS AND IMPLICATIONS: These results demonstrate for the first time that beat-to-beat ventricular repolarization variability and @entity943 induced by @entity2781 are dependent on endogenous HF autonomic oscillations in heart rate. When combined with evidence of @entity9493 -blocking properties, enhancement of endogenous @entity2198 in heart rate could constitute an earlier and more sensitive biomarker than STVQT for @entity1166 , applicable to preclinical regulatory studies conducted in healthy animals.

title: Short-term variability in QT interval and XXXX induced by @entity2781 are dependent on high-frequency autonomic oscillations.

entities_list: @entity4033 :: ('MESH:D018738', 'Chemical') :: ['hexamethonium']

entities_list: @entity2781 :: ('MESH:C063533', 'Chemical') :: ['dofetilide']

entities_list: @entity2198 :: ('MESH:D006316', 'Disease') :: ['HF oscillations', 'when HF oscillations', 'QT interval high-frequency (HF) oscillations']

entities_list: @entity1166 :: ('MESH:D016171', 'Disease') :: ['Torsades de pointes liability', 'Torsades de pointes']

entities_list: @entity235 :: ('9615', 'Species') :: ['beagle dogs', 'dogs']

entities_list: @entity5434 :: ('9541', 'Species') :: ['cynomolgus monkeys']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'Ventricular arrhythmias']

answer: @entity943 :: (MESH:D001145,Disease) :: ['ventricular arrhythmias']


abstract: BACKGROUND AND PURPOSE: The present study was undertaken to investigate an effect of @entity2781 , a potent arrhythmic blocker of the voltage-gated @entity3529 channel, @entity9493 , on cardiac autonomic control. Combined with effects on ardiomyocytes, these properties could influence its arrhythmic potency. EXPERIMENTAL APPROACH: The short-term variability of beat-to-beat QT interval (STVQT ), induced by @entity2781 is a strong surrogate of @entity1166 . Involvement of autonomic modulation in STVQT was investigated in healthy @entity5434 and @entity235 by power spectral analysis under conditions of autonomic blockade with @entity4033 . KEY RESULTS: Increase in STVQT induced by @entity2781 in monkeys and @entity235 was closely associated with an enhancement of endogenous heart rate and @entity2198 . These effects were fully suppressed under conditions of autonomic blockade with @entity4033 . @entity943 , including @entity1166 in monkeys, were prevented in both species @entity2198 were suppressed by autonomic blockade. Similar enhancements of heart rate @entity2198 were found in @entity235 with other @entity9493 blockers described as causing @entity1166 in @entity1 . CONCLUSIONS AND IMPLICATIONS: These results demonstrate for the first time that beat-to-beat ventricular repolarization variability and @entity943 induced by @entity2781 are dependent on endogenous HF autonomic oscillations in heart rate. When combined with evidence of @entity9493 -blocking properties, enhancement of endogenous @entity2198 in heart rate could constitute an earlier and more sensitive biomarker than STVQT for @entity1166 , applicable to preclinical regulatory studies conducted in healthy animals.

title: Short-term variability in QT interval and @entity943 induced by XXXX are dependent on high-frequency autonomic oscillations.

answer: @entity2781 :: (MESH:C063533,Chemical) :: ['dofetilide']


abstract: UNASSIGNED: In @entity1 , @entity8450 delays the onset of sweating and cutaneous vasodilation during heat stress. However, it remains unknown if hyperosmolality exerts this effect through a central (i.e. central nervous system) and/or peripheral (i.e. effector organ) modulation of thermoregulatory activity. We examined if intravenous infusion of hyperosmotic saline affects skin sympathetic nerve activity (SSNA) during whole-body passive heating in healthy @entity1 . Furthermore, we examined if local intradermal infusion of hyperosmotic saline affects sweating and cutaneous vasodilation during passive heating. Following intravenous infusion of either 0.9% ( @entity8670 ) or 3.0% (HYPER) @entity4202 saline, 12 subjects were passively heated until core temperature increased by    0.6  C. During each condition, sweating and cutaneous vascular conductance were measured over two intradermal microdialysis probes, one perfused with @entity8670 saline and the other with HYPER saline. Intravenous infusion of HYPER saline increased plasma osmolality (294      3 to 316      5 mOsm/kgH2 O, P   <=  0.01), which remained greater than @entity8670 throughout heating. Plasma hyperosmolality delayed the mean body temperature onset of sweating (+1.24      0.18  vs. +1.60      0.18  C, P   <=  0.01) and cutaneous vasodilation (+1.15      0.18  vs. +1.53      0.22  C, P   <=  0.01), and attenuated the increase in SSNA during heating (+147      178  vs. +427      281%, P   <=  0.01). Intradermal infusion of HYPER saline increased baseline CVC (P   <=  0.01), which did not increase further during the subsequent heating period (P  =  0.11). In contrast, intradermal infusion of HYPER saline did not affect sweating (P  =  0.99). These results provide direct evidence that @entity8450 exerts a central modulatory effect governing efferent thermoregulatory activity in @entity1 . This article is protected by copyright. All rights reserved.

title: Plasma hyperosmolality attenuates skin sympathetic nerve activity during passive heat stress in XXXX .

entities_list: @entity8450 :: ('MESH:D054219', 'Disease') :: ['plasma hyperosmolality']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: UNASSIGNED: Sleep is beneficial to learning, but the underlying mechanisms remain controversial. The synaptic homeostasis hypothesis (SHY) proposes that the cognitive function of sleep is related to a generalized rescaling of synaptic weights to intermediate levels, due to a passive downregulation of plasticity mechanisms. A competing hypothesis proposes that the active upscaling and downscaling of synaptic weights during @entity25 memories in circuits respectively activated or deactivated during prior waking experience, leading to memory changes beyond rescaling. Both theories have empirical support but the experimental designs underlying the conflicting studies are not congruent, therefore a consensus is yet to be reached. To advance this issue, we used real-time PCR and electrophysiological recordings to assess gene expression related to synaptic plasticity in the hippocampus and primary somatosensory cortex of @entity35 exposed to novel objects, then kept awake (WK) for 60min and finally killed after a 30min period rich in WK, @entity25 ( @entity25 ) or @entity11755 ( @entity11755 ). Animals similarly treated but not exposed to novel objects were used as controls. We found that the mRNA levels of Arc, @entity11970 , @entity5019 , @entity71923 and @entity71924 were significantly increased in the hippocampus of exposed animals allowed to enter @entity11755 , in comparison with control animals. Experience-dependent changes during sleep were not significant in the hippocampus for @entity2136 , @entity49370 , @entity14889 , and @entity27803 , and no differences were detected between exposed and control @entity25 groups for any of the genes tested. No significant changes in gene expression were detected in the primary somatosensory cortex during sleep, in contrast with previous studies using longer post-stimulation intervals (>180min). The experience-dependent induction of multiple plasticity-related genes in the hippocampus during early @entity11755 adds experimental support to the synaptic embossing theory.

title: Experience-dependent upregulation of multiple plasticity factors in the hippocampus during early XXXX sleep.

entities_list: @entity11755 :: ('MESH:D020187', 'Disease') :: ['rapid-eye-movement sleep', 'REM']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['slow-wave sleep', 'SWS', 'sleep embosses']

answer: @entity11755 :: (MESH:D020187,Disease) :: ['REM']


abstract: BACKGROUND: Anti- @entity3391 ( @entity3391 ) encephalitis is an autoimmune disorder of the central nervous system which presents acutely with seizures, disturbances in consciousness and behavioural change. Although there is an increasing amount of information about the diagnosis and acute treatment strategies, little is known about rehabilitation needs and outcomes for this @entity1 group. CASE REPORT: This study presents a 52-year old @entity1 who initially presented with generalized seizures and drowsiness. She was admitted to hospital where autoimmune encephalitis was diagnosed based on a positive serum anti- @entity3391 antibody titre. When medically stabilized, she was transferred to a specialist neurorehabilitation unit for ongoing care. Her main clinical issues were around behavioural disturbance, communication, continence, mobility and cognition. A multi-disciplinary approach was taken to her problems and she was eventually discharged back to community living having made substantial improvements in all domains of functioning. The clinical challenges encountered throughout her rehabilitation and the approach to ameliorating these is described. CONCLUSION: Although having a relatively rare diagnosis, the specific rehabilitation needs of this @entity1 were met through an existing specialist neurorehabilitation service. A broader case series is required to determine needs and effective approaches across this @entity1 group as a whole.

title: Rehabilitation following anti- XXXX encephalitis.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity3391 :: ('D016202', 'Chemical') :: ['NMDA', 'N-methyl D-Aspartate']

answer: @entity3391 :: (D016202,Chemical) :: ['NMDA']


abstract: Periodontal @entity281 cause inflammatory destruction of the tooth supporting tissues. We recently developed a dynamic, in vitro periodontal organotypic tissue model in a perfusion bioreactor system, in co-culture with an 11-species subgingival biofilm, which may recapitulate early events during the establishment of periodontal @entity281 . This study aimed to characterize the global proteome regulations in this host-biofilm interaction model. Semi-quantitative shotgun proteomics were applied for protein identification and quantification in the co-culture supernatants ( @entity1 and bacterial) and the biofilm lysates (bacterial). A total of 896 and 3363 proteins were identified as secreted in the supernatant and expressed in the biofilm lysate, respectively. Enriched gene ontology analysis revealed that the regulated secreted @entity1 tissue proteins were related to processes of cytoskeletal rearrangement, stress responses, apoptosis, and antigen presentation, all of which are commensurate with deregulated host responses. Most secreted bacterial biofilm proteins derived from their cytoplasmic domain. In the presence of the tissue, the levels of @entity8209 , Actinomyces oris and Campylobacter rectus proteins were significantly regulated. The functions of the up-regulated intracellular (biofilm lysate) proteins were associated with cytokinesis. In conclusion, the proteomic overview of regulated pathways in this host-biofilm interaction model provides insights to the early events of periodontal pathogenesis.

title: Proteomic profiling of host-biofilm interactions in an XXXX model resembling the periodontal pocket.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity8209 :: ('851', 'Species') :: ['Fusobacterium nucleatum']

answer: @entity281 :: (MESH:D007239,Disease) :: ['oral infection']