abstract: UNASSIGNED: @entity1593 ( @entity1593 ) is a common @entity792 characterized by heightened immunological response to ingested gluten. Certain gene polymorphisms of @entity1199 / @entity15787 ( @entity12549 and @entity71062 ) and @entity31694 ( @entity31703 ) may influence susceptibility to @entity1593 , although the effects remain unclear. We performed a meta-analysis of the associations between @entity12549 , @entity71062 , and @entity31703 polymorphisms and @entity1593 risk. PubMed, EMBASE, and the China National Knowledge Infrastructure were searched. ORs and 95%CIs of each single nucleotide polymorphism (SNP) were estimated using the fixed-effect model if I(2) < 50% in the test of heterogeneity; otherwise, the random-effect model was used. Our meta-analysis included 12,986 @entity1593 cases and 28,733 controls from 16 independent samples, and the analysis of each SNP contained a subset of the total. We found that the minor allele T of both @entity12549 (T vs G, OR = 0.72, 95%CI = 0.67-0.78, P < 0.001) and @entity71062 (T vs C, OR = 0.76, 95%CI = 0.71-0.83, P < 0.001) in @entity1199 / @entity15787 significantly decreased the risk of @entity1593 . However, the minor allele A of @entity31703 (A vs G, OR = 1.18, 95%CI = 1.12-1.24, P < 0.001) in @entity31694 significantly increased @entity1593 susceptibility. The estimated lambda values were 0.49, 0.50, and 0.53 for @entity12549 , @entity71062 , and @entity31703 , respectively, suggesting that a co-dominant model of genotype effect was most appropriate for the three SNPs. Our results support associations between the three SNPs and @entity1593 and provide a strong argument for further research.

title: Association between @entity1199 / XXXX and @entity31694 polymorphisms and risk of celiac disease: a meta-analysis.

answer: @entity15787 :: (59067,Gene) :: ['IL21']


abstract: During an 18-month period, 82 consecutive @entity1 (37 @entity1 and 45 @entity1 ), with a mean age of 50 yr (range 15 to 74), underwent hemodialysis with 91 @entity2636 double-lumen subclavian superior vena cava catheters inserted via the right subclavian vein. Upon catheter removal, venograms were performed in 53 which revealed @entity715 in 13. Autopsy performed in 13 other @entity1 revealed @entity715 in three. Mean catheter duration was 27 days (range 1 to 138). Catheter duration was significantly (p less than .01) longer in the 16 cases complicated by @entity715 . There was no significant difference in the frequency of @entity715 between @entity1 and @entity1 . Two @entity1 developed symptoms of subclavian @entity2994 after the creation of an @entity2548 on the same side as a previous hemodialysis catheter. Overall, @entity715 was found in 23% and increased with longer catheter duration. We recommend phlebography to exclude @entity715 before creating an @entity2548 on the same side as the previous hemodialysis catheter. There was no case of clinical discernible @entity1151 .

title: @entity715 caused by XXXX double-lumen subclavian superior vena cava catheter and hemodialysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity2994 :: ('MESH:D012170', 'Disease') :: ['vein occlusion']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity2548 :: ('MESH:D001164', 'Disease') :: ['arteriovenous fistula']

entities_list: @entity2636 :: ('MESH:D011140', 'Chemical') :: ['polyurethane']

answer: @entity2636 :: (MESH:D011140,Chemical) :: ['polyurethane']


abstract: During an 18-month period, 82 consecutive @entity1 (37 @entity1 and 45 @entity1 ), with a mean age of 50 yr (range 15 to 74), underwent hemodialysis with 91 @entity2636 double-lumen subclavian superior vena cava catheters inserted via the right subclavian vein. Upon catheter removal, venograms were performed in 53 which revealed @entity715 in 13. Autopsy performed in 13 other @entity1 revealed @entity715 in three. Mean catheter duration was 27 days (range 1 to 138). Catheter duration was significantly (p less than .01) longer in the 16 cases complicated by @entity715 . There was no significant difference in the frequency of @entity715 between @entity1 and @entity1 . Two @entity1 developed symptoms of subclavian @entity2994 after the creation of an @entity2548 on the same side as a previous hemodialysis catheter. Overall, @entity715 was found in 23% and increased with longer catheter duration. We recommend phlebography to exclude @entity715 before creating an @entity2548 on the same side as the previous hemodialysis catheter. There was no case of clinical discernible @entity1151 .

title: XXXX caused by @entity2636 double-lumen subclavian superior vena cava catheter and hemodialysis.

answer: @entity715 :: (MESH:D013927,Disease) :: ['Thrombosis']


abstract: Normally a freeze-thaw cycle is a very efficient method of killing @entity1 cells. However, this report describes conditions that prevent killing of cultured @entity1 cells by nucleated freezing at -24 degrees C. Optimal protection from cell killing at -24 degrees C was obtained in isotonic solutions containing an organic cryoprotectant such as @entity3733 ( @entity3733 ; 10%, v/v), a @entity1735 such as @entity969 over a broad concentration range from 50 to 150 mM, and @entity413 . @entity653 was also an effective cryoprotectant but other organic solvents were ineffective, although in some cases they appeared to protect cell membranes, while not protecting other vital components. A wide variety of @entity1735 structures were effective at protecting cells from freeze-thaw killing, with @entity7970 being particularly effective. The degree of resistance to killing by a freeze-thaw cycle under these conditions varied widely among different cell lines. If @entity137 of @entity3733 was responsible for this variability of cryoprotection, it must have been due to short-term, not longer term, @entity137 of @entity3733 . Studies on the mechanism by which cells are protected from killing under these conditions indicated that neither vitrification of the medium nor the concentrating of components during freezing were involved. One model not eliminated by the mechanistic studies proposes that the organic solvent cryoprotectant component acts by fluidizing membranes under the thawing conditions, so that any holes produced by ice crystals propagating through membranes can reseal during the thawing process. In this model one of the mechanisms by which the @entity1735 component could act is by entering the cells and stabilizing vital intracellular components. Consistent with this, a freeze-thaw cycle promoted the uptake of labeled @entity969 into cultured cells.

title: Studies on the mechanisms of XXXX cell killing by a freeze-thaw cycle: conditions that prevent cell killing using nucleated freezing.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity7970 :: ('MESH:D014199', 'Chemical') :: ['trehalose']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['saccharide']

entities_list: @entity3733 :: ('MESH:D004121', 'Chemical') :: ['dimethyl sulfoxide', 'DMSO']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['Glycerol']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1 :: (9606,Species) :: ['mammalian']


abstract: Eyes of laboratory @entity235 with an @entity74 were abnormally lightly pigmented. The development of pigmentation was followed morphologically from 7 days postnatal to 9 years of age. At all postnatal ages the iris pigmented epithelia contained no normal melanosomes, only organelles resembling secondary lysosomes or residual bodies. The ciliary body pigmented epithelium contained a variety of melanosome organelles at the earliest stages examined, but in fewer numbers than in normal animals. These included premelanosomes, partially melanized and some fully melanized pigment granules. However, the melanin deposition was usually patchy and irregular. With time, many of these granules appeared to condense into residual bodies. The retinal pigmented epithelium in peripheral and inferior posterior regions of affected animals never contained normal appearing melanin granules at any stage of postnatal development. The iris and @entity3193 had melanosomes of normal size and shape, but many fewer than in normal animals. These results imply that there is local cellular control over melanosome production and regression, since the @entity854 do not follow the anterior to posterior development of @entity2118 . It is proposed that a defect in synthesis of the matrix component of melanosomes could result in absent or abnormal deposition of melanin and initiate a process of autophagy of these organelles.

title: Melanosome abnormalities of ocular pigmented epithelial cells in XXXX with hereditary tapetal degeneration.

entities_list: @entity235 :: ('9615', 'Species') :: ['beagle dogs']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['melanosome abnormalities']

entities_list: @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal stroma']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited tapetal degeneration']

entities_list: @entity2118 :: ('MESH:D010859', 'Disease') :: ['pigment in ocular epithelia']

answer: @entity235 :: (9615,Species) :: ['beagle dogs']


abstract: Exercise can cause @entity925 for a number of reasons. Usually the @entity158 is experienced during the exercise and recovers rapidly afterwards. There is one type of @entity925 that has a very different and characteristic time course. In this situation the exercise itself, and the immediate post-exercise period are painfree. The @entity158 is not felt for about eight hours and is maximal 1 or 2 days later. Delayed onset @entity925 occurs after unaccustomed, high force contractions and is particularly associated with eccentric contractions. The concensus of opinion is that the @entity158 is caused by some form of damage, but the mechanism for the @entity158 is not known. This review summarises the literature on the consequences of eccentric contractions and relates them to delayed onset @entity925 . There is clear evidence of damage to the muscle fibres themselves, their membranes and, at a later stage, mononuclear cell infiltration, but all these have very different time courses and none are the same as the @entity158 . Intramuscular pressures are raised in some, but not all, painful compartments and even when raised follow a different time course to the @entity158 . Anti-inflammatory agents do not affect the @entity158 , but due to the incomplete understanding of the action of these drugs, the role of @entity32 in delayed onset @entity925 is uncertain. Despite the considerable evidence of damage after eccentric contractions, the cause of delayed onset @entity925 is still unknown.

title: The consequences of eccentric contractions and their relationship to delayed onset XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle pain']

answer: @entity925 :: (MESH:D063806,Disease) :: ['muscle pain']


abstract: Fifty-three @entity1 with @entity1358 received treatment with combinations of recombinant alpha (rIFN-alpha-2a) and gamma ( @entity3692 ) interferons on three different treatment schedules. On treatment schedule A, 13 @entity1 received i.m. rIFN-alpha-2a and @entity3692 simultaneously at a 1:1 ratio by dose units (2 X 10(6) U/m2), equivalent to a 1:10 ratio by protein weight. Results included severe constitutional symptoms in 62% of the @entity1 and no partial remissions (PR) or complete remissions among 10 evaluable @entity1 . On treatment schedule B, 25 @entity1 received an i.m. injection of rIFN-alpha-2a and @entity3692 simultaneously at a 1:1 ratio by protein weight (2 X 10(6) U/m2 and 2 X 10(5) U/m2, respectively). This schedule was well tolerated, allowing a 25-50% increment in over 75% of the @entity1 . Four @entity1 (16%) achieved PR. On treatment schedule C, 15 @entity1 received alternating weekly therapy: first @entity3692 /m2 daily for 7 days) followed by rIFN-alpha-2a (10 X 10(6) U/m2 daily for 7 days). One of 13 evaluable @entity1 in treatment schedule C achieved an 80% @entity5 reduction and was rendered free of disease after the primary @entity5 was resected. @entity137 was similar in nature to that of rIFN-alpha-2a or @entity3692 separately. The @entity137 of treatment schedule A suggested additive toxic effects. No distinct synergistic antitumor effect was observed.

title: Recombinant interferon alpha and gamma in combination as treatment for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['metastatic-renal cell carcinoma']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['metastatic renal cell carcinoma']


abstract: BACKGROUND AND AIMS: @entity8324 represents 3% of @entity1790 in @entity1 . Two genes have been identified as the main genetic causes of @entity8324 , @entity32372 and @entity15007 , with an autosomal recessive mode of inheritance. In the present study, we studied for the first time, genetically and clinically, all the cystinuric families identified so far in the Greek-Cypriot population. METHODS: Discovery of mutations was performed through polymerase chain reaction (PCR)-single analysis and DNA resequencing. New families were investigated through PCR-RFLPs. Clinical data were collected through the hospital @entity1 ' records and analytical follow-up of the families. RESULTS AND DISCUSSION: We found a total of five mutations in 28 Greek-Cypriot cystinuric @entity1 belonging in 12 families. The most frequent mutation among the 28 Greek-Cypriot @entity1 is the @entity32372 - @entity58545 , which is also the second most frequent mutation in Europe, representing a genetic founder effect. Sixteen of the 28 @entity1 are homozygous for this mutation. Even though a consanguinity loop was obvious in only one family, other @entity1 were from families in small villages where endogamy was practiced for many centuries. Timely clinical and genetic diagnosis, accompanied by early treatment, is significant for the good health of most of our @entity1 . Only    14% of them developed @entity177 , and only one reached @entity454 ( @entity454 ). CONCLUSION: Five @entity32372 and @entity15007 mutations appear to be responsible for the genetic basis of @entity8324 in the Greek-Cypriot @entity1 ; having such a limited number of causative mutations will simplify diagnostics for this population.

title: Molecular and Clinical Investigation of XXXX in the Greek-Cypriot Population.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patients']

entities_list: @entity8324 :: ('MESH:D003555', 'Disease') :: ['cystinuria', 'Cystinuria']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure']

entities_list: @entity1790 :: ('MESH:D053040', 'Disease') :: ['nephrolithiasis']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']

answer: @entity8324 :: (MESH:D003555,Disease) :: ['Cystinuria']


abstract: The administration of fat emulsion and total parenteral nutrition ( @entity8856 ) was evaluated in 68 @entity1 with @entity409 who underwent surgical treatment for esophageal varices. The subjects were divided into two groups, fat group (28 cases) and non-fat group (40 cases) according to with or without the administration of fat emulsion during the period of postoperative @entity8856 . The results of liver function tests, blood @entity413 levels, intravenous fat tolerance tests, serum lipid levels, @entity844 composition in serum total lipids, @entity1568 balances and body weight changes during the period of postoperative @entity8856 were compared between both groups. Conclusions as follows; 1. The administration of fat emulsion during the period of postoperative @entity8856 did not worsen the results of liver function tests, and relatively low levels of blood @entity413 were retained. 2. The removal rates of fat emulsion from the blood (K2 values) during the period of postoperative @entity8856 were significantly higher than in those preoperative period, and changes in serum lipid level revealed no tendency toward retention of fat emulsion administered intravenously. 3. Cumulative @entity1568 balance were almost similar in both groups. 4. The administration of fat emulsion the period of during postoperative @entity8856 corrected the abnormalities of @entity844 composition in serum total lipid. Further, it was suggested that approximately more than 5 ml/kg/day of 10% fat emulsion would be advisable to prevent the decrease of @entity4722 . 5. These results suggested that the administration of fat emulsion was useful for the @entity1 with esophageal varices during the period of postoperative @entity8856 .

title: [Postoperative total parenteral nutrition with fat emulsion for XXXX with esophageal varices].

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disorders']

entities_list: @entity4722 :: ('MESH:D019787', 'Chemical') :: ['linoleic acid']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Persistent or recurrent @entity298 ( @entity298 ) documented at second-look surgery has proved relatively refractory to second-line therapy. The majority of these @entity5 do not respond to @entity900 based chemotherapy. Because of the relatively high response rate we observed with systemically administered @entity1138 plus @entity1487 , we initiated a trial of intraperitoneal (IP) @entity1138 (10 mg/m2 in 2 L dialysate fluid every 4 weeks) in 14 @entity1 with refractory @entity298 secondary to gynecologic @entity5 . All but one @entity1 had @entity298 secondary to @entity43 documented at second-look cytoreductive surgery following intense @entity900 based drug therapy. One @entity1 had @entity1204 and had been treated previously with radiation. In all, 49 courses of intraperitoneal @entity1138 were administered to 14 @entity1 . Systemic @entity137 was minimal, except for mild @entity882 that occurred in four @entity1 . However, @entity490 due to @entity298 was cumulative and dose limiting after three to five courses of therapy. Of the seven @entity1 with measurable disease (positive serum CA-125 or intraperitoneal cytology), six had normalization of at least one of these two parameters. Eight of the 14 @entity1 remain alive without clinical evidence of disease with a median follow-up duration of 10 months. We conclude that IP @entity1138 is a well-tolerated and potentially effective treatment modality in @entity1 with limited @entity298 following second-look surgical debulking for gynecologic @entity5 .

title: Intraperitoneal XXXX in the treatment of @entity298 following second-look surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies', 'malignancy', 'tumors']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal carcinomatosis', 'PC', 'chemical peritonitis']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin C']


abstract: Persistent or recurrent @entity298 ( @entity298 ) documented at second-look surgery has proved relatively refractory to second-line therapy. The majority of these @entity5 do not respond to @entity900 based chemotherapy. Because of the relatively high response rate we observed with systemically administered @entity1138 plus @entity1487 , we initiated a trial of intraperitoneal (IP) @entity1138 (10 mg/m2 in 2 L dialysate fluid every 4 weeks) in 14 @entity1 with refractory @entity298 secondary to gynecologic @entity5 . All but one @entity1 had @entity298 secondary to @entity43 documented at second-look cytoreductive surgery following intense @entity900 based drug therapy. One @entity1 had @entity1204 and had been treated previously with radiation. In all, 49 courses of intraperitoneal @entity1138 were administered to 14 @entity1 . Systemic @entity137 was minimal, except for mild @entity882 that occurred in four @entity1 . However, @entity490 due to @entity298 was cumulative and dose limiting after three to five courses of therapy. Of the seven @entity1 with measurable disease (positive serum CA-125 or intraperitoneal cytology), six had normalization of at least one of these two parameters. Eight of the 14 @entity1 remain alive without clinical evidence of disease with a median follow-up duration of 10 months. We conclude that IP @entity1138 is a well-tolerated and potentially effective treatment modality in @entity1 with limited @entity298 following second-look surgical debulking for gynecologic @entity5 .

title: Intraperitoneal @entity1138 in the treatment of XXXX following second-look surgery.

answer: @entity298 :: (MESH:D010538,Disease) :: ['peritoneal carcinomatosis']


abstract: To estimate the actual states of uterine body invasion of @entity2622 , 301 radically hysterectomized specimens were reviewed histologically. Incidence of uterine body invasion was 21.6% in all cases (65 cases out of 301), 7.8% in stage Ib, 25.5% in stage IIa, and 38.2% in stage IIb. Most of the positive invasion cases had spread to other surrounding tissues. Vaginal wall was invaded in 58.5% of all positive cases, parametrial infiltration was recognized in 87.7%, and pelvic lymph node @entity3 was seen in 52.3%. On the contrary, in negative cases these were 33.9, 19.1, and 15.7%, respectively. There was a higher incidence of the L type of Imai's CPL classification among positive cases of uterine body invasion than among negative cases (81.5% vs 38.1%). When @entity5 spread into the uterine body, peritoneal @entity189 and distant @entity3 increased. Thus the outcome of @entity1 with positive invasion was, naturally, poor. @entity1 with negative invasion had a 5-year survival rate of 92.4%, compared to 53.8% in @entity1 with positive uterine body invasion. These results suggest that uterine body invasion of @entity2622 is an important prognostic factor and treatment should be modified in such cases.

title: Uterine body invasion of XXXX as seen from surgical specimens.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer']

entities_list: @entity2622 :: ('MESH:D002583', 'Disease') :: ['carcinoma of the uterine cervix']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity2622 :: (MESH:D002583,Disease) :: ['carcinoma of the uterine cervix']


abstract: OBJECTIVE: Uncontrolled @entity548 from junctional wounds that cannot be controlled by traditional tourniquets accounts for one in five preventable battlefield exsanguination deaths. Products for treating these wounds are costly and require special training. However, chemically treated gauze products are inexpensive, potentially effective, and require only minimal training. This study was designed to assess the efficacy of three hemostatic gauze products following brief training, using a consensus @entity1707 groin injury model. METHODS: After viewing a 15-minute PowerPoint presentation, without demonstration or practice, 24 U.S. Navy Corpsmen, most with little to no live tissue or hemostatic agent experience, applied one of three hemostatic agents: QuikClot Combat Gauze, Celox @entity130 Gauze, or Hemcon ChitoGauze. Animals were resuscitated and monitored for 150 minutes to assess @entity1613 , @entity190 , rebleeding, and survival. @entity1 completed a survey before training and following testing. RESULTS: Products were similar in @entity1613 , @entity190 , and rebleeding. Twenty-three @entity1707 survived (96%). Ease of use and perceived efficacy of training ratings were high. Comfort level with application improved following training. CONCLUSIONS: Hemostatic gauze can potentially be effective for treating junctional wounds following minimal training, which has important implications for corpsmen, self-aid/buddy-aid, civilian providers, and Tactical Combat Casualty Care guidelines.

title: Control of Junctional XXXX in a Consensus @entity1707 Model With Hemostatic Gauze Products Following Minimal Training.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity1613 :: ('MESH:D011230', 'Disease') :: ['initial hemostasis']

answer: @entity548 :: (MESH:D006470,Disease) :: ['Hemorrhage']


abstract: OBJECTIVE: Uncontrolled @entity548 from junctional wounds that cannot be controlled by traditional tourniquets accounts for one in five preventable battlefield exsanguination deaths. Products for treating these wounds are costly and require special training. However, chemically treated gauze products are inexpensive, potentially effective, and require only minimal training. This study was designed to assess the efficacy of three hemostatic gauze products following brief training, using a consensus @entity1707 groin injury model. METHODS: After viewing a 15-minute PowerPoint presentation, without demonstration or practice, 24 U.S. Navy Corpsmen, most with little to no live tissue or hemostatic agent experience, applied one of three hemostatic agents: QuikClot Combat Gauze, Celox @entity130 Gauze, or Hemcon ChitoGauze. Animals were resuscitated and monitored for 150 minutes to assess @entity1613 , @entity190 , rebleeding, and survival. @entity1 completed a survey before training and following testing. RESULTS: Products were similar in @entity1613 , @entity190 , and rebleeding. Twenty-three @entity1707 survived (96%). Ease of use and perceived efficacy of training ratings were high. Comfort level with application improved following training. CONCLUSIONS: Hemostatic gauze can potentially be effective for treating junctional wounds following minimal training, which has important implications for corpsmen, self-aid/buddy-aid, civilian providers, and Tactical Combat Casualty Care guidelines.

title: Control of Junctional @entity548 in a Consensus XXXX Model With Hemostatic Gauze Products Following Minimal Training.

answer: @entity1707 :: (9823,Species) :: ['Swine']


abstract: Idiopathic @entity3454 , also called @entity195 , has been estimated to affect 5 p. 100 of the general population. Normally a benign disease, it becomes life-threatening in only a very small number of cases. High risk subjects could be detected by simple TM-mode echocardiography, provided this examination is of good quality and reproducible, for it shows a 5 mm or more thickening of mitral leaflets. Should this be the case, according to the Mayo Clinic authors, serious complications, such as @entity944 , @entity884 or @entity64 , would be expected to occur in 10 p. 100 of the @entity1 . @entity944 , of which only 60 cases have been published, is exceptional; it mainly concerns young subjects (mean age 40 years), predominantly @entity1 , with a family history of @entity944 , who have experienced one or several @entity1163 and present with severe per- or intercritical @entity943 . Such subjects must be regularly supervised clinically as well as by basal or ambulatory electrocardiography and, if necessary, by electrophysiological or even haemodynamic exploration. Treatment with appropriate beta-blockers or antiarrhythmic agents is often required as is, in refractory cases, implantation of an @entity10804 . @entity884 is a cause of @entity204 in 10 to 20 p. 100 of the @entity1 . It mainly threatens subjects whose @entity339 is suspected on the presence of a holo- or end-systolic murmur and confirmed by Doppler echocardiography.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [ XXXX and risk for life].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic cerebral vascular accidents']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral valve regurgitation']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death', 'Sudden death']

entities_list: @entity10804 :: ('MESH:C537069', 'Disease') :: ['automatic defibrillator']

entities_list: @entity3454 :: ('MESH:D008945', 'Disease') :: ['mitral valve prolapse']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Barlow's disease"]

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['dysrhythmias']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['Infective endocarditis', 'infective endocarditis']

answer: @entity195 :: (MESH:D000544,Disease) :: ['Barlow's disease']


abstract: Between 1983 and 1986, 41 @entity1 with a @entity957 without hematogenic @entity3 were treated with a combination of radio- and chemotherapy preoperatively. Treatment consisted of @entity1138 (10 mg/sqm/day 1) and continuous infusion of 5 @entity1487 (1000 mg/sqm/day-day 1 to 4) with a maximum of 1500 mg per day. On day 2 radiotherapy was started. After the administration of 36 Gy all @entity1 were restaged. Nine @entity1 were referred to surgery. In 13 cases surgery was refused, because of inoperability, due to local or distant @entity3 . In these @entity1 radiotherapy was continued up to 50 to 60 Gy for palliation. Although the disease was confined to the oesophagus no surgery was performed in 19 @entity1 , because of age, enhanced risk of anaesthesia or refusal by the @entity1 . These @entity1 were treated with radiotherapy alone (60 Gy) with curative intention. 32 @entity1 treated without surgery were followed up. For the @entity1 treated with curative intent, the one year survival rate was 62%, the two year survival rate was 42%. Compared to a group treated in 1970 bis 1982 with the same dosage of irradiation without the combination of chemotherapy the median survival could be raized from nine to 24 months, the two year survival rate improved from 18% to 42%. @entity1 treated for palliation only did not survive the first year after therapy.

title: [Simultaneous radio- and chemotherapy of XXXX of the esophagus].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma of the oesophagus']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']

answer: @entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinoma']


abstract: The temporal relationship between @entity7438 release and gonadotropin secretion as well as the effects of castration on @entity7438 release were investigated in conscious, freely moving male @entity35 . @entity7438 release was measured in @entity1640 /median eminence perfusates, while levels of pituitary gonadotropins (LH, FSH) were determined in sequential blood samples obtained via atrial catheters. Twenty-four to 26 h before experiments, @entity35 underwent sham surgery or castration. @entity7438 release in push-pull perfusates from both groups was pulsatile, and nearly all identified LH pulses (83.3%) were temporally associated with @entity7438 pulses. Of the fewer irregular FSH pulses that were observed, only 43.7% were temporally associated with @entity7438 pulses. Mean @entity7438 pulse amplitude and mean @entity7438 levels were not different in intact and castrate animals. The frequency of @entity7438 pulses was moderately increased in castrate @entity35 (1.30 pulses/h) compared to that in intact animals (0.83 pulses/h), and this acceleration was accompanied by a significant increase in LH pulse frequency, pulse amplitude, and mean level. It was also noted that the number of silent @entity7438 pulses (those not associated with LH pulses) was dramatically reduced in castrate animals. Characteristics of gonadotropin release (pulse frequency, pulse amplitude, and mean level) were not significantly different in animals undergoing push-pull perfusion/bleeding procedures from those in @entity35 not receiving push-pull cannula implants. We conclude from these studies that 1) LH pulses show a high concordance with @entity7438 pulses, providing evidence that the @entity7438 pulse generator operates as the neural determinant of LH pulses in male @entity35 , 2) FSH secretion is not associated with @entity7438 release in an obvious and consistent manner, suggesting that @entity7438 /FSH relationships are not easily discerned in these animals or that a FSH-releasing factor distinct from the @entity7438 decapeptide may regulate FSH secretion, 3) a modest increase in @entity7438 pulse frequency occurs 24-30 h after castration, and 4) silent @entity7438 pulses occur with much greater regularity in intact than in castrate @entity35 . The latter two observations suggest that both @entity1640 and intrapituitary sequelae of castration may be critically important in the development of postcastration increases in LH secretion and the negative feedback of gonadal @entity230 .

title: Simultaneous measurement of luteinizing hormone (LH)-releasing hormone, LH, and follicle-stimulating hormone release in intact and short-term castrate XXXX .

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity1640 :: ('MESH:D007027', 'Disease') :: ['hypothalamic']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: Monoclonal antibodies were produced against serum-derived @entity291 immunoglobulin E (IgE). Culture supernatants of hybridomas were initially screened by enzyme-linked immunosorbent assay (ELISA). Supernatant-derived antibodies were concentrated and further characterized using ELISA, reverse cutaneous anaphylaxis, immunohistochemical staining, and immunoblotting of IgE-containing samples separated by @entity214 - @entity2975 gel electrophoresis (PAGE). Eight monoclonal antibodies showed specificity for @entity291 epsilon immunoglobulin heavy chain. Two antibodies (E2 and E32) reacted in immunoblots of @entity214 -PAGE of serum IgE under reducing conditions. Additionally, E2, E5, and E32 detected epsilon chain in serum separated by @entity214 -PAGE and then renatured. Antigen-specific IgE was detected in Western blots by E5 and E32. Immunoperoxidase staining of IgE-containing cells in mesenteric lymph node sections was detected with E5, E21 and E32. All eight antibodies produced positive reverse cutaneous anaphylaxis reactions in @entity291 skin. All functioned well in ELISA as a plate-sensitizing reagent for quantitation of total IgE; E5 and E32 worked well as a primary antibody in antigen-specific IgE assays. These antibodies will be useful in research applications and in diagnostic assays.

title: Generation and characterization of murine monoclonal antibodies specific for XXXX immunoglobulin E.

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: PURPOSE: To evaluate irregularity of the anterior @entity267 before and after Descemet stripping endothelial keratoplasty (DSEK) for @entity2372 and its effect on visual acuity. METHODS: Corneal data were acquired using a topographic unit before and up to 12 months after DSEK. Anterior corneal elevation data were decomposed into a set of Zernike polynomials up to the 8th order within a 6.0-mm diameter region. Total @entity2008 ( @entity2008 ) and root mean square from the 3rd to 8th order were calculated. The effects of anterior surface irregularity on visual acuity were evaluated. RESULTS: This clinical study comprised 20 consecutive eyes of 20 @entity1 with @entity2372 . The mean corrected distance visual acuity (CDVA) was 1.00    0.12 logMAR (SD) preoperatively and 0.24    0.16 logMAR 12 months postoperatively. Before DSEK, corneas with @entity2372 had higher total @entity2008 compared with those in controls (p<0.05). There were no significant differences in anterior surface @entity2008 between preoperatively and 12 months (p>0.05). CONCLUSIONS: Postoperative CDVA correlated with irregularity of the corneal anterior surface. Corneal anterior @entity2008 are higher in @entity1 with @entity2372 than in controls, and remain higher through 12 months after DSEK. In addition to corneal transparency, regularity of the corneal anterior surface is an important factor in visual acuity after DSEK.

title: Anterior corneal surface irregularity after Descemet-stripping endothelial keratoplasty for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['HOAs', 'higher-order aberrations']

entities_list: @entity2372 :: ('MESH:C562399', 'Disease') :: ['bullous keratopathy']

answer: @entity2372 :: (MESH:C562399,Disease) :: ['bullous keratopathy']


abstract: Transabdominal posterior rectopexy with resection of the redundant left colon (Frykman-Goldberg operation) was performed on 48 selected @entity1 with @entity3577 . Uterine suspension was also performed on most of the @entity1 . The 30-day mortality rate was 2.1%. Prolapse recurred in 4 (9%) of the 45 @entity1 followed up for 1-10 (mean 4.3) years. There were no complications attributable to bowel resection or @entity254 . Adequate data on both preoperative and postoperative anal function and bowel habit were available in 41 cases. All but two of the 32 @entity1 with associated @entity322 experienced improved anal control after the operation (9 regained normal continence). Bowel habit improved in 23 @entity1 (56%), especially in those with chronic @entity1142 . No @entity1 reported increased problems of bowel management. The operation does not involve the risks associated with implantation of foreign material and can be especially beneficial for constipated @entity1 with @entity3577 who are fit for major abdominal surgery.

title: Abdominal rectopexy and sigmoid resection (Frykman-Goldberg operation) for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity3577 :: ('MESH:D056887', 'Disease') :: ['complete rectal prolapse', 'rectal prolapse']

answer: @entity3577 :: (MESH:D056887,Disease) :: ['rectal prolapse']


abstract: The choroid plexus and its associated epiplexus cells in the fourth ventricle in @entity468 were studied with scanning and transmission electron microscopy (SEM, TEM) following a cisternal injection of @entity36315 complex (phospholipase A2). In SEM, the epiplexus cells of the control animals were predominantly stellate with long radiating processes. At 2 h after the administration of crotoxin complex, these radiating processes flattened out forming sheet-like membranes covering the ventricular surface of the choroid epithelial cells. The membranous coverings remained extended in 5-hour-survival @entity468 . Numerous @entity4530 of different sizes were observed in areas that were not covered by the cytoplasmic membrane in 5-hour animals. Some of the @entity4530 appeared to have @entity397 . In TEM, the microvilli of the choroid epithelial cells in crotoxin complex-treated @entity35 were dilated. The luminal surface of the epithelial cells showed eruption of @entity4530 filled with amorphous materials. Pinocytotic vesicles increased in number in the apical cytoplasm. The lumen of the ventricle often contained portions of cytoplasm believed to be derived from the extrusion of the @entity4530 . These appeared to be engulfed by the overlying epiplexus cells. It was concluded that the injected crotoxin complex stimulated both the secretory as well as pinocytotic activity of the choroid epithelial cells. The phagocytosis of the secretory products from the epithelial cells by epiplexus cells suggests a close functional relationship between the two cell types.

title: Electron-microscopical study of the choroid plexus and epiplexus cells in XXXX following a cisternal injection of crotoxin complex.

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptured']

answer: @entity468 :: (9685,Species) :: ['cats']


abstract: The process of prenatal diagnosis is unique in that the diagnosis and prognosis are made without seeing the @entity1 . 45, @entity31370 presents a special problem in this regard. The phenotype of 45,X/46,XY postnatally diagnosed @entity1 (pediatric group) was compared to that of 6 fetuses who were diagnosed from 7,000 amniocenteses (prenatal group). These amniocenteses were performed primarily because of an increased risk of @entity2008 . The pediatric group (age birth-18 yr) were all phenotypically abnormal, although none were @entity1032 . Seven @entity1 presented with @entity4998 , while 2 had primary @entity2588 . Sexual assignment was changed in 2. Abnormalities included @entity790 , @entity2650 , undescended testes, and @entity851 . All 9 @entity1 required at least one surgical procedure. In contrast, the prenatally diagnosed fetuses (ages 3 months to 3 1/2 yr) were all phenotypically normal males. Four were noted to have male genitalia on ultrasonography. Thus, the phenotype of 45, @entity31370 in prenatally diagnosed fetuses can be markedly different from that of individuals diagnosed postnatally. This must be considered when counseling @entity1 .

title: 45, XXXX : contrast of prenatal and postnatal diagnosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mentally retarded']

entities_list: @entity4998 :: ('MESH:D012734', 'Disease') :: ['ambiguous genitalia']

entities_list: @entity2650 :: ('MESH:D007021', 'Disease') :: ['hypospadias']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['short stature']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosome abnormality']

entities_list: @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea']

entities_list: @entity790 :: ('MESH:D014564', 'Disease') :: ['rudimentary phallus, urogenital sinus']

answer: @entity31370 :: (MESH:C564513,Disease) :: ['X/46,XY mosaicism']


abstract: Between 1961 and 1985, 44 cases of @entity5 were experienced at Gunma University Hospital. We statistically analyzed 42 of them. The average age was 56.9 years old, ranging from 28 to 86 years old. Interval from onset of the disease to first visit to our hospital ranged from 0 to 50 months, averaging 9 months. The main chief complaints were mass formation, spontaneous @entity158 , @entity1066 , and abnormality of urinary stream. More than 75% of them had phimosis. Thirty-one percent had stage 1, 29% stage 2, 38% stage 3, and 2% stage 4 @entity5 , according to Jackson's classification. All of them were diagnosed with @entity957 . Surgical treatment was given to 37 @entity1 (radical or partial penectomy was performed in most cases). Chemotherapy was given to 23 @entity1 (main chemotherapeutic agent was @entity1732 or @entity6030 ) and irradiation to 26 @entity1 . Five-year survival was seen in 77% of the cases, 92% in low stage group (stage 1 and 2) and 63% in high stage group (stage 3 and 4). Ten-year survival was seen in 62% of the cases, 79% in low stage group and 43% in high stage group (Kaplan-Meier method).

title: [Statistical study of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['penile cancer', 'cancer']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']

entities_list: @entity6030 :: ('MESH:D017663', 'Chemical') :: ['peplomycin']

answer: @entity5 :: (MESH:D009369,Disease) :: ['penile cancer']


abstract: @entity9990 of salivary glands are relative rare and it has often been difficult to correlate the pathologic features and clinical aspects. The literature recommends long term follow-up studies. The object of the present study was therefore to follow this recommendation. The clinico-pathological features of 39 @entity9990 are presented. The material was retrieved from the files of the pathological institute, Rigshospitalet, Copenhagen, during the period 1941-75. All @entity1 , 24 males, 15 females, were followed for a minimum of 5 years. The lesions were classified into low grade (13 cases), intermediate grade (14 cases) and high grade (12 cases). The corresponding 5, 10 and 15 years cumulative survival rates were 92%, 92%, 92% for low grade, 47.4%, 47.4%, 35.5% for intermediate grade and 0%, 0%, 0% for high grade @entity5 . Thus we found a close correlation between pathology and clinical course. Furthermore, a 5 year observation period appeared an acceptable approach, because 17 of the 18 @entity1 who succumbed of the disease, did so within 4 years following surgery. We consider all grades of @entity9990 to be potential malignant. In our study one @entity1 with a low grade @entity5 died of the disease.

title: XXXX of salivary glands. A long term follow-up study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity9990 :: ('MESH:D018298', 'Disease') :: ['mucoepidermoid tumors', 'Mucoepidermoid tumors']

answer: @entity9990 :: (MESH:D018298,Disease) :: ['Mucoepidermoid tumors']


abstract: Two major forms of hepatic microsomal cytochrome P-450 were purified from starved and @entity1324 -treated @entity35 . On the basis of @entity535 sequence analysis, they were identified as @entity11920 and @entity4921 . @entity1068 or @entity1324 treatment of @entity35 caused a 9-fold increase in the amount of @entity11920 in liver microsomes accompanied by similar increases in the rate of @entity1110 -dependent metabolism of @entity4314 , @entity1324 , and @entity7935 . Immunological experiments indicated that @entity11920 constitutes the major catalyst of the microsomal metabolism of the latter agents and contributes by about 50% to microsomal P-450-dependent @entity1068 oxidation under the conditions used. The @entity11920 -dependent catalytic activities had a high rate of turnover. In contrast, this was not the case for the immunodetectable @entity11920 , indicating the occurrence of inactive forms of this protein in microsomes. Starvation or @entity1068 or @entity1324 treatment caused 10-30-fold increases in the amount of both mRNA and apoprotein of @entity4921 ,e compared to control. Run-on experiments and the concomitant increases of the @entity4921 gene products at the mRNA and protein levels indicated the appearance of mainly a transcriptional activation by @entity1324 , @entity1068 , or starvation. Fasting exerted, in addition, a pronounced synergistic effect on @entity1324 -dependent induction of @entity4921 ,e mRNA (3-fold), apo- @entity4921 ,e (4.3-fold), @entity11920 mRNA (2-fold), and apo- @entity11920 (2-fold). No increase of mRNA coding for @entity11920 , compared to control, was seen after @entity1324 or @entity1068 treatment alone. The results indicate that effects of @entity1068 , @entity1324 , and/or starvation on drug and xenobiotic metabolism are caused by the induction of P-450 forms belonging to at least two gene subfamilies.

title: XXXX -, fasting-, and @entity1324 -inducible cytochromes P-450 in @entity35 liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies.

entities_list: @entity4314 :: ('MESH:D002251', 'Chemical') :: ['carbon tetrachloride']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity1068 :: ('MESH:D000431', 'Chemical') :: ['Ethanol', 'ethanol']

answer: @entity1068 :: (MESH:D000431,Chemical) :: ['Ethanol']


abstract: Two major forms of hepatic microsomal cytochrome P-450 were purified from starved and @entity1324 -treated @entity35 . On the basis of @entity535 sequence analysis, they were identified as @entity11920 and @entity4921 . @entity1068 or @entity1324 treatment of @entity35 caused a 9-fold increase in the amount of @entity11920 in liver microsomes accompanied by similar increases in the rate of @entity1110 -dependent metabolism of @entity4314 , @entity1324 , and @entity7935 . Immunological experiments indicated that @entity11920 constitutes the major catalyst of the microsomal metabolism of the latter agents and contributes by about 50% to microsomal P-450-dependent @entity1068 oxidation under the conditions used. The @entity11920 -dependent catalytic activities had a high rate of turnover. In contrast, this was not the case for the immunodetectable @entity11920 , indicating the occurrence of inactive forms of this protein in microsomes. Starvation or @entity1068 or @entity1324 treatment caused 10-30-fold increases in the amount of both mRNA and apoprotein of @entity4921 ,e compared to control. Run-on experiments and the concomitant increases of the @entity4921 gene products at the mRNA and protein levels indicated the appearance of mainly a transcriptional activation by @entity1324 , @entity1068 , or starvation. Fasting exerted, in addition, a pronounced synergistic effect on @entity1324 -dependent induction of @entity4921 ,e mRNA (3-fold), apo- @entity4921 ,e (4.3-fold), @entity11920 mRNA (2-fold), and apo- @entity11920 (2-fold). No increase of mRNA coding for @entity11920 , compared to control, was seen after @entity1324 or @entity1068 treatment alone. The results indicate that effects of @entity1068 , @entity1324 , and/or starvation on drug and xenobiotic metabolism are caused by the induction of P-450 forms belonging to at least two gene subfamilies.

title: @entity1068 -, fasting-, and XXXX -inducible cytochromes P-450 in @entity35 liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies.

answer: @entity1324 :: (MESH:D000096,Chemical) :: ['acetone']


abstract: Two major forms of hepatic microsomal cytochrome P-450 were purified from starved and @entity1324 -treated @entity35 . On the basis of @entity535 sequence analysis, they were identified as @entity11920 and @entity4921 . @entity1068 or @entity1324 treatment of @entity35 caused a 9-fold increase in the amount of @entity11920 in liver microsomes accompanied by similar increases in the rate of @entity1110 -dependent metabolism of @entity4314 , @entity1324 , and @entity7935 . Immunological experiments indicated that @entity11920 constitutes the major catalyst of the microsomal metabolism of the latter agents and contributes by about 50% to microsomal P-450-dependent @entity1068 oxidation under the conditions used. The @entity11920 -dependent catalytic activities had a high rate of turnover. In contrast, this was not the case for the immunodetectable @entity11920 , indicating the occurrence of inactive forms of this protein in microsomes. Starvation or @entity1068 or @entity1324 treatment caused 10-30-fold increases in the amount of both mRNA and apoprotein of @entity4921 ,e compared to control. Run-on experiments and the concomitant increases of the @entity4921 gene products at the mRNA and protein levels indicated the appearance of mainly a transcriptional activation by @entity1324 , @entity1068 , or starvation. Fasting exerted, in addition, a pronounced synergistic effect on @entity1324 -dependent induction of @entity4921 ,e mRNA (3-fold), apo- @entity4921 ,e (4.3-fold), @entity11920 mRNA (2-fold), and apo- @entity11920 (2-fold). No increase of mRNA coding for @entity11920 , compared to control, was seen after @entity1324 or @entity1068 treatment alone. The results indicate that effects of @entity1068 , @entity1324 , and/or starvation on drug and xenobiotic metabolism are caused by the induction of P-450 forms belonging to at least two gene subfamilies.

title: @entity1068 -, fasting-, and @entity1324 -inducible cytochromes P-450 in XXXX liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: In recent years, several attempts have been made to characterize the nature of the @entity73 shown by @entity1 with @entity191 . It has been suggested variously that they have difficulty in switching cognitive set, in performing effortful (or controlled) as opposed to automatic tasks, or that their impairment is found in tasks which maximize the amount of 'self-directed task specific planning'. It is proposed that this latter distinction may be reformulated in terms of the degree of internal versus external attentional control which is required by the task. An experiment is described which attempted to manipulate this parameter. A version of the Stroop colour-word test was used, in which the words 'red' and 'green' were presented in the complementary coloured 'ink'. Subjects responded either to the colour of the ink in which the word was written or the colour named by the word. The relevant attribute changed at intervals during the course of the experiment. In one condition, the relevant stimulus attribute was cued before each trial. In another condition, subjects had to remember which attribute was currently relevant. Results revealed that @entity1 with @entity191 were impaired mainly on the second version of the task which required internal attentional control. The results are discussed in relation to the models of Working Memory (Baddeley, 1986), and attentional control (Norman and Shallice, 1980). Exploration of these models leads to the formulation of a theory in which the crucial @entity73 in @entity191 is reduced resources in the Supervisory Attentional System. Provided the demands of the task are within the @entity1 's available attentional resources the @entity1 may not show any deficit. If, however, the attentional demands exceed available resources, as in tasks which depend upon internal cues, then deficits will be observed.

title: Internal versus external cues and the control of attention in XXXX .

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits', 'determinant of cognitive impairment']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: @entity5260 / @entity1068 extract of normal @entity35 liver, both in vitro and in vivo, inhibited the invasion by a highly invasive subpopulation of @entity35 ascites @entity157 cells, AH 130 (LC-AH cells). The addition of 10-80 micrograms/ml extract inhibited the formation of penetrated colonies of LC-AH cells underneath the cultured mesothelial cell (M-cell) monolayer. The @entity5 cells pretreated with the extract showed the diminished colony formation. Preincubation of the extract with plasma membranes prepared from LC-AH cells abolished the effect of the extract, suggesting a binding of the inhibitory entity [tentatively termed as "invasion-inhibiting factor" (IIF)] to the @entity5 cell surface. The extract did not inhibit the growth of LC-AH cells, but suppressed their directed migration underneath the M-cell monolayer. A concomitant i.p. injection of the extract with LC-AH cells into @entity35 prevented the invasion by @entity5 cells of the peritoneum and formation of @entity5 nodules in the peritoneum and mediastinum, indicating that IIF inhibited the @entity5 cell invasion and @entity3 in vivo, as well. Upon ultrafiltration and gel fractionation, about 60% of IIF activity was recovered in the fraction corresponding to the molecular weight in the range of Mr 3000-4000. This activity was heat-stable at 100 degrees C at neutral pH but labile at acidic pH and was inactivated by the treatment with pronase. The rest of the activity of IIF was found in the fraction of more than Mr 25,000.

title: Factor from @entity35 liver with antiinvasive potential on @entity35 ascites XXXX cells.

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatoma']


abstract: @entity5260 / @entity1068 extract of normal @entity35 liver, both in vitro and in vivo, inhibited the invasion by a highly invasive subpopulation of @entity35 ascites @entity157 cells, AH 130 (LC-AH cells). The addition of 10-80 micrograms/ml extract inhibited the formation of penetrated colonies of LC-AH cells underneath the cultured mesothelial cell (M-cell) monolayer. The @entity5 cells pretreated with the extract showed the diminished colony formation. Preincubation of the extract with plasma membranes prepared from LC-AH cells abolished the effect of the extract, suggesting a binding of the inhibitory entity [tentatively termed as "invasion-inhibiting factor" (IIF)] to the @entity5 cell surface. The extract did not inhibit the growth of LC-AH cells, but suppressed their directed migration underneath the M-cell monolayer. A concomitant i.p. injection of the extract with LC-AH cells into @entity35 prevented the invasion by @entity5 cells of the peritoneum and formation of @entity5 nodules in the peritoneum and mediastinum, indicating that IIF inhibited the @entity5 cell invasion and @entity3 in vivo, as well. Upon ultrafiltration and gel fractionation, about 60% of IIF activity was recovered in the fraction corresponding to the molecular weight in the range of Mr 3000-4000. This activity was heat-stable at 100 degrees C at neutral pH but labile at acidic pH and was inactivated by the treatment with pronase. The rest of the activity of IIF was found in the fraction of more than Mr 25,000.

title: Factor from XXXX liver with antiinvasive potential on @entity35 ascites @entity157 cells.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: @entity5260 / @entity1068 extract of normal @entity35 liver, both in vitro and in vivo, inhibited the invasion by a highly invasive subpopulation of @entity35 ascites @entity157 cells, AH 130 (LC-AH cells). The addition of 10-80 micrograms/ml extract inhibited the formation of penetrated colonies of LC-AH cells underneath the cultured mesothelial cell (M-cell) monolayer. The @entity5 cells pretreated with the extract showed the diminished colony formation. Preincubation of the extract with plasma membranes prepared from LC-AH cells abolished the effect of the extract, suggesting a binding of the inhibitory entity [tentatively termed as "invasion-inhibiting factor" (IIF)] to the @entity5 cell surface. The extract did not inhibit the growth of LC-AH cells, but suppressed their directed migration underneath the M-cell monolayer. A concomitant i.p. injection of the extract with LC-AH cells into @entity35 prevented the invasion by @entity5 cells of the peritoneum and formation of @entity5 nodules in the peritoneum and mediastinum, indicating that IIF inhibited the @entity5 cell invasion and @entity3 in vivo, as well. Upon ultrafiltration and gel fractionation, about 60% of IIF activity was recovered in the fraction corresponding to the molecular weight in the range of Mr 3000-4000. This activity was heat-stable at 100 degrees C at neutral pH but labile at acidic pH and was inactivated by the treatment with pronase. The rest of the activity of IIF was found in the fraction of more than Mr 25,000.

title: Factor from @entity35 liver with antiinvasive potential on XXXX ascites @entity157 cells.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: 1. Alkaline phosphatase activity in @entity53424 -induced @entity35 mammary @entity5 was compared with activity in normal and lactating mammary gland. 2. Both @entity5 and normal mammary alkaline phosphatase were sensitive to heat inactivation and inhibition by @entity815 . 3. Specific activity of enzyme in @entity5 was comparable to normal mammary tissue. 4. Mammary gland alkaline phosphatase increased markedly in late pregnancy and early lactation. 5. @entity9697 treatment had no effect on enzyme activity in lactating mammary gland.

title: Comparison of alkaline phosphatase activity in normal, lactating and neoplastic XXXX mammary tissue.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity9697 :: ('CHEBI:3181', 'Chemical') :: ['Bromocryptine']

entities_list: @entity815 :: ('CHEBI:28044', 'Chemical') :: ['phenylalanine']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Recent biochemical studies have led to the identification of abnormal spectrins in the erythrocytes of @entity1 with @entity21427 ( @entity21427 ) and @entity9048 ( @entity9048 ). In this report we describe the biochemical characterization of the erythrocytes from a proband with severe @entity21427 who is doubly heterozygous for two mutant spectrins (Sp): @entity3231 I/74 and a new, previously undetected, mutant of alpha-spectrin designated @entity3231 I/61. The proband's erythrocytes are unstable when exposed to 45 degrees C, and her membrane skeletons exhibit instability to shear stress. The content of spectrin in the proband's erythrocyte membranes is decreased to 75% of control values. The amount of spectrin dimers in crude 4 degrees C spectrin extracts is increased (58%) as compared with control values (6% +/- 4%). Limited tryptic digestion reveals a marked decrease in the normal 80,000-dalton alpha I domain, an increase in the 74,000-dalton fragment that is characteristic of @entity3231 I/74, and an increase in a series of new fragments of 61,000, 55,000, 21,000, and 16,000 daltons. Both parents are asymptomatic, but they have increased amounts of spectrin dimers (17% to 25%). Limited tryptic digestion of the father's spectrin demonstrates the presence of a previously identified abnormal spectrin ( @entity3231 I/74) that is characterized by a decrease in content of the 80,000-dalton peptide and an increase in concentration of the 74,000-dalton peptide. The mother's spectrin digests show a decrease in the amount of 80,000-dalton peptide and the formation of new peptides of 61,000, 55,000, 21,000, and 16,000 daltons. The data indicate that this severe form of @entity21427 is due to the inheritance of two distinct abnormal spectrins, @entity3231 I/74 and a new spectrin mutant, @entity3231 I/61.

title: Spectrin-alpha I/61: a new structural variant of alpha-spectrin in a double-heterozygous form of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity21427 :: ('MESH:C563004', 'Disease') :: ['HPP', 'hereditary pyropoikilocytosis']

entities_list: @entity9048 :: ('MESH:D004612', 'Disease') :: ['HE', 'hereditary elliptocytosis']

answer: @entity21427 :: (MESH:C563004,Disease) :: ['hereditary pyropoikilocytosis']


abstract: Forty @entity1 with relapsed (26) or refractory (14) @entity1582 were treated with @entity1259 of doses of 75, 90, 105, and 120 mg/m2 in groups of 6 or more @entity1 to test for response, maximum tolerated dose, and @entity137 . Thirteen @entity1 had received prior @entity632 and were included in the dose findings part of the study only. Staging was I (1), II (5), and III (34). Partial responses were seen in 5 @entity1 (18.5%) (duration 1.5, 2, 2.5, 10, and 18 months) not previously treated with @entity632 . No responses were seen in @entity1 treated with prior @entity4349 . Responses were not dependent upon dose level of @entity1259 . Median nadir white blood cell count at the four-dose levels were 2,300, 1,000, 1,600, and 1,700/mm3 with median nadir granulocyte counts of 897, 720, 688, and 192/mm3. @entity221 / @entity1398 was infrequently observed at the three lower dose levels but occurred in 6 of 10 @entity1 at 120 mg/m2. Platelet nadirs were 110,000, 83,000, 169,000, and 42,000/mm3. Nonhematological @entity137 was not dose dependent and included @entity1665 (100%), @entity390 / @entity391 (40%), and @entity3136 (25%). Six @entity1 had greater than or equal to 0.10 changes in the resting ejection fraction with one @entity1 developing @entity712 that responded to medical management. This @entity1 had received prior @entity632 and had a history of @entity583 . @entity1259 can produce remissions in @entity1 with previously treated @entity1582 who have not received prior @entity632 . Since the response rate was not enhanced at 120/m2 and since @entity221 / @entity1398 was seen regularly at this dose level, the recommended dose for further study is 105 mg/m2.

title: Phase I-II study of XXXX in @entity1582 .

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity4349 :: ('CHEBI:48120', 'Chemical') :: ['anthracycline']

entities_list: @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin', 'Epirubicin']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity1259 :: (MESH:D015251,Chemical) :: ['epirubicin']


abstract: Forty @entity1 with relapsed (26) or refractory (14) @entity1582 were treated with @entity1259 of doses of 75, 90, 105, and 120 mg/m2 in groups of 6 or more @entity1 to test for response, maximum tolerated dose, and @entity137 . Thirteen @entity1 had received prior @entity632 and were included in the dose findings part of the study only. Staging was I (1), II (5), and III (34). Partial responses were seen in 5 @entity1 (18.5%) (duration 1.5, 2, 2.5, 10, and 18 months) not previously treated with @entity632 . No responses were seen in @entity1 treated with prior @entity4349 . Responses were not dependent upon dose level of @entity1259 . Median nadir white blood cell count at the four-dose levels were 2,300, 1,000, 1,600, and 1,700/mm3 with median nadir granulocyte counts of 897, 720, 688, and 192/mm3. @entity221 / @entity1398 was infrequently observed at the three lower dose levels but occurred in 6 of 10 @entity1 at 120 mg/m2. Platelet nadirs were 110,000, 83,000, 169,000, and 42,000/mm3. Nonhematological @entity137 was not dose dependent and included @entity1665 (100%), @entity390 / @entity391 (40%), and @entity3136 (25%). Six @entity1 had greater than or equal to 0.10 changes in the resting ejection fraction with one @entity1 developing @entity712 that responded to medical management. This @entity1 had received prior @entity632 and had a history of @entity583 . @entity1259 can produce remissions in @entity1 with previously treated @entity1582 who have not received prior @entity632 . Since the response rate was not enhanced at 120/m2 and since @entity221 / @entity1398 was seen regularly at this dose level, the recommended dose for further study is 105 mg/m2.

title: Phase I-II study of @entity1259 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['multiple myeloma']


abstract: Intravertebral infusion of angiotensin II ( @entity51038 II) increases mean arterial pressure (MAP), but the contribution of cardiac output (CO) and total peripheral resistance (TPR) to this increase is unclear. In the present study, the effects of @entity51038 II infusion on CO and regional blood flow was determined by the microsphere technique in eight conscious, chronically catheterized @entity235 . @entity51038 II was infused into both vertebral arteries at 0.33 and 1.0 ng/kg/min, and intravenously at 0.66, 2.0 and 5.0 ng/kg/min. Intravertebral infusion of @entity51038 II at 0.33 ng/kg/min increased MAP by increasing CO without changing TPR or peripheral plasma @entity51038 II concentration. MAP also was increased with intravertebral infusion of @entity51038 II at 1.0 ng/kg/min, but this resulted from small increases in both CO and TPR. In contrast, intravenous infusion of @entity51038 II at 2.0 and 5.0 ng/kg/min increased MAP by increasing TPR in association with a decrease in CO. The increase in CO with intravertebral infusion of @entity51038 II at 0.33 ng/kg/min was distributed primarily to the muscles, kidneys, heart, and brain. Intravenous infusion of @entity51038 II at 5.0 ng/kg/min and, to a lesser extent, 2.0 ng/kg/min decreased blood flow to the skin, splanchnic region, and kidneys. These data indicate that the increase in MAP produced by a low intravertebral dose of @entity51038 II results from an increase in CO, which is distributed primarily to the muscle, kidney, heart, and brain. In contrast, the increase in MAP produced by a higher intravertebral dose of @entity51038 II results from increases in CO and TPR. This latter action is apparently due to a peripheral action of @entity51038 II to increase resistance in the skin, @entity8 .

title: Effect of intravertebral angiotensin II on cardiac output and its distribution in conscious XXXX .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['splanchnic, and renal circulations']

answer: @entity235 :: (9615,Species) :: ['dogs']


abstract: We studied 980 @entity1 with a first episode of @entity1459 or @entity583 ( @entity583 ), to examine age-related differences in risk factors and in-hospital complications and mortality. Of the total group, 52.9% were over 60 years of age and 24.3% over 70 years. The proportion of females rose with increasing age, as did the proportion of ex-smokers, while the proportion of current smokers fell. Age correlated negatively with total @entity165 levels, and positively with high-density lipoprotein @entity165 levels. The proportion of @entity101 rose with age, as did in-hospital systolic, but not diastolic, blood pressure. Older @entity1 were more likely to have @entity6 , and to have had chronic @entity951 . There was no relation between age and either size or site of @entity1188 . the proportion admitted with @entity1459 fell with age, and, among @entity1188 , the proportion developing complications rose. Mortality rose from 3.1% in the under 60 subjects to 20.0% in those over 70. @entity1455 tended to become more lethal with advancing age, but the outcome of @entity2224 was not influenced by age. With the current aging coronary care population, management and secondary prevention methods derived from studies confined to younger subjects may be inappropriate.

title: Risk factors and in-hospital course of first XXXX in the elderly.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity1459 :: ('MESH:D000789', 'Disease') :: ['unstable angina']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions', 'infarction']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['Cardiogenic shock']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: The design of a microperfusion chamber is presented for use with spermatozoa or other cell suspensions. This chamber allows perfusion of a small number of spermatozoa during simultaneous observation of cell behavior at the microscope. The chamber is made from a flat glass capillary tube that is fitted at both ends with a filter unit containing Millipore filter discs. The entire assembly is designed to fit the stage of an inverted microscope. A population containing as few as several hundred sperm cells may be observed in the chamber during successive changes of the suspending medium as controlled by a perfusion pump. Several experiments are presented demonstrating sperm survival in the sealed chamber and the response of @entity95 and @entity1 sperm @entity1319 after the washing process. For these manipulations, the percentage of motile cells, linear swimming speed and incidence of hyperactivated @entity1319 are reported. Simple incubation in the chamber for 1 hour was not deleterious to the @entity1319 of @entity95 spermatozoa. @entity1 seminal spermatozoa showed no decline in vigorous @entity1319 after the washing procedure. Compared with in vitro capacitated spermatozoa, however, washing of @entity95 seminal spermatozoa showed a variable response. Finally, partially capacitated @entity1 spermatozoa were examined for any alteration of @entity1319 during chamber incubation with a subsequent wash. When small numbers of spermatozoa or other cell types must be manipulated, the methodology can be effectively substituted for the standard washing procedure that uses repeated centrifugation and resuspension.

title: A microperfusion chamber for study of XXXX spermatozoa.

answer: @entity1 :: (9606,Species) :: ['mammalian']


abstract: The decision to seek secondary treatment for @entity2419 is often the result of concerns about the esthetic acceptability of appearance. There are no standard techniques to assess @entity2419 for esthetic acceptability. Therefore, it is not possible to evaluate objectively either the need for or the benefits of treatment. If it could be shown that @entity1 agree closely on how they rate the esthetic appearance of @entity2419 that vary in severity, then esthetic measures of @entity2419 could be developed with @entity1 judgment as the yardstick. The goals of this study were: (1) to examine the reliability with which @entity1 express their preferences for @entity2419 that vary in severity, (2) to determine if other facial characteristics influence the reliability of @entity1 's preferences for @entity2419 , and (3) to evaluate if age and gender of @entity1 influence preferences for @entity2419 . Based on preratings, eight types of photographic slides were created that varied in severity of @entity2419 and global facial attractiveness. A second sample of subjects then rated the slides on the esthetic acceptability of appearance. @entity1 ranked the photographic types consistently. They least preferred the photographic types depicting severe @entity73 , or both, and most preferred faces with no impairment or moderate attractiveness, or both. There were also developmental effects in that younger @entity1 tended to have less consensus in their ratings of appearance than older @entity1 . Finally, @entity1 displayed greater consensus than @entity1 .

title: Reliability of esthetic ratings of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human', 'Children', 'boys', 'girls', 'people']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impairment or low facial attractiveness']

entities_list: @entity2419 :: ('MESH:D002972', 'Disease') :: ['cleft impairments', 'facial clefts', 'cleft impairment']

answer: @entity2419 :: (MESH:D002972,Disease) :: ['cleft impairment']


abstract: With the theory that @entity4391 is caused by sympathetic inhibition of contractility in the colon as a basis, 18 @entity1 with acute @entity4391 were enrolled in a treatment program assessing the safety and efficacy of sympathetic blockade, by epidural anesthesia, in those who failed conservative management. In some cases colonoscopy had been performed initially and, if unsuccessful, these @entity1 were referred for treatment with epidural anesthesia. Seven @entity1 recovered with conservative treatment alone. One @entity1 refused further treatment and died of her underlying disease. Five of eight @entity1 treated by epidural anesthesia responded. There were no recurrences following successful epidural anesthesia. Five of eight @entity1 treated by colonoscopic decompression responded. No @entity1 required surgical intervention. One @entity1 suffered a @entity1188 during colonoscopy. There were no significant complications from epidural anesthesia. Epidural anesthesia is safe, effective, simple, and well tolerated in the management of @entity4391 .

title: Epidural anesthesia for XXXX ( @entity4391 ).

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['subendocardial infarction']

entities_list: @entity4391 :: ('MESH:D003112', 'Disease') :: ["Ogilvie's syndrome", 'colonic pseudo-obstruction']

answer: @entity4391 :: (MESH:D003112,Disease) :: ['acute pseudo-obstruction of the colon']


abstract: With the theory that @entity4391 is caused by sympathetic inhibition of contractility in the colon as a basis, 18 @entity1 with acute @entity4391 were enrolled in a treatment program assessing the safety and efficacy of sympathetic blockade, by epidural anesthesia, in those who failed conservative management. In some cases colonoscopy had been performed initially and, if unsuccessful, these @entity1 were referred for treatment with epidural anesthesia. Seven @entity1 recovered with conservative treatment alone. One @entity1 refused further treatment and died of her underlying disease. Five of eight @entity1 treated by epidural anesthesia responded. There were no recurrences following successful epidural anesthesia. Five of eight @entity1 treated by colonoscopic decompression responded. No @entity1 required surgical intervention. One @entity1 suffered a @entity1188 during colonoscopy. There were no significant complications from epidural anesthesia. Epidural anesthesia is safe, effective, simple, and well tolerated in the management of @entity4391 .

title: Epidural anesthesia for @entity4391 ( XXXX ).

answer: @entity4391 :: (MESH:D003112,Disease) :: ['Ogilvie's syndrome']


abstract: One hundred and sixty-one @entity1 who were treated with @entity1568 mustard, @entity1891 , @entity4174 , and @entity617 (MOPP) chemotherapy for @entity978 have been observed for a median of 10.2 years. Eighty-two percent of those @entity1 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity1 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity353 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity1 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity1 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity1 who had died at the time of the analysis of this series, 46 died of progressive @entity978 . All four @entity1 who developed secondary @entity3052 had received radiation as well as MOPP.

title: @entity1568 mustard, XXXX , @entity4174 , and @entity617 for relapse after radiation in @entity978 . An analysis of long-term follow-up.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity4174 :: ('MESH:D011344', 'Chemical') :: ['procarbazine']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute nonlymphocytic leukemia']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

answer: @entity1891 :: (MESH:D014750,Chemical) :: ['vincristine']


abstract: One hundred and sixty-one @entity1 who were treated with @entity1568 mustard, @entity1891 , @entity4174 , and @entity617 (MOPP) chemotherapy for @entity978 have been observed for a median of 10.2 years. Eighty-two percent of those @entity1 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity1 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity353 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity1 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity1 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity1 who had died at the time of the analysis of this series, 46 died of progressive @entity978 . All four @entity1 who developed secondary @entity3052 had received radiation as well as MOPP.

title: XXXX mustard, @entity1891 , @entity4174 , and @entity617 for relapse after radiation in @entity978 . An analysis of long-term follow-up.

answer: @entity1568 :: (MESH:D009584,Chemical) :: ['Nitrogen']


abstract: One hundred and sixty-one @entity1 who were treated with @entity1568 mustard, @entity1891 , @entity4174 , and @entity617 (MOPP) chemotherapy for @entity978 have been observed for a median of 10.2 years. Eighty-two percent of those @entity1 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity1 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity353 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity1 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity1 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity1 who had died at the time of the analysis of this series, 46 died of progressive @entity978 . All four @entity1 who developed secondary @entity3052 had received radiation as well as MOPP.

title: @entity1568 mustard, @entity1891 , @entity4174 , and @entity617 for relapse after radiation in XXXX . An analysis of long-term follow-up.

answer: @entity978 :: (MESH:D006689,Disease) :: ['Hodgkin's disease']


abstract: One hundred and sixty-one @entity1 who were treated with @entity1568 mustard, @entity1891 , @entity4174 , and @entity617 (MOPP) chemotherapy for @entity978 have been observed for a median of 10.2 years. Eighty-two percent of those @entity1 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity1 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity353 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity1 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity1 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity1 who had died at the time of the analysis of this series, 46 died of progressive @entity978 . All four @entity1 who developed secondary @entity3052 had received radiation as well as MOPP.

title: @entity1568 mustard, @entity1891 , XXXX , and @entity617 for relapse after radiation in @entity978 . An analysis of long-term follow-up.

answer: @entity4174 :: (MESH:D011344,Chemical) :: ['procarbazine']


abstract: One hundred and sixty-one @entity1 who were treated with @entity1568 mustard, @entity1891 , @entity4174 , and @entity617 (MOPP) chemotherapy for @entity978 have been observed for a median of 10.2 years. Eighty-two percent of those @entity1 received MOPP after relapse from previous irradiation. The complete response (CR) rate was 71%. For the 116 @entity1 achieving CR the relapse-free survival at 5 years was 83% and at 10 years, 79%. The overall survival was 72% at 5 years and 64% at 10 years. In a stepwise logistic regression analysis the most important clinical factors influencing response were B symptoms at presentation (fever greater than 38 degrees C, night sweats, @entity353 greater than 10% of body weight), histologic subtype, and lung or pleural involvement. @entity1 who received MOPP as first-line therapy had a significantly worse response rate than those who received MOPP upon relapse after radiotherapy. This difference is reduced when adjustments are made for the presence of the above prognostic factors. A Cox regression analysis showed that Stage IV at presentation and lymphocyte-depleted histology were the most important factors indicating reduced survival. @entity1 who achieved a CR to MOPP had a significantly improved survival. Of the 65 @entity1 who had died at the time of the analysis of this series, 46 died of progressive @entity978 . All four @entity1 who developed secondary @entity3052 had received radiation as well as MOPP.

title: @entity1568 mustard, @entity1891 , @entity4174 , and XXXX for relapse after radiation in @entity978 . An analysis of long-term follow-up.

answer: @entity617 :: (MESH:D011239,Chemical) :: ['prednisolone']


abstract: With single-beat analysis, the new concept of systolic @entity296 is applied to provide a new approach for the assessment of myocardial contractility in aortic and @entity339 . Seventy @entity1 underwent diagnostic right and left heart catheterization. Twenty-six @entity1 had @entity472 , 18 had @entity337 , and 26 had @entity339 . @entity1 with @entity472 were divided into two groups on the basis of left ventricular mass index less than 172 g/m2 ( @entity1673 ) and mass index greater than or equal to 172 g/m2 (AS2). The @entity339 @entity1 were divided into those in normal sinus rhythm ( @entity29817 ) and those in @entity955 (MR2). Nine @entity1 without significant @entity65 served as controls. Thirteen @entity1 with @entity472 and eight with @entity337 were evaluated (average, approximately 18 months) after successful aortic valve replacement. With simultaneous left ventricular pressure and cineangiographic methods, myocardial contractility was assessed by the conventional ejection fraction-afterload relation (uncorrected for preload) and by two new methods that permit the correction of the ejection fraction for preload. Assessments of the contractile state by these two new methods differed from those by the conventional method in 20-40% of the cases studied. Contractile state improved postoperatively in @entity472 and @entity337 even in @entity1 with preoperative depressed contractile states. In @entity1 with @entity339 , there was considerable heterogeneity of contractile function preoperatively. Severe left @entity123 in @entity472 was not a marker for postoperative outcome since contractility was normal postoperatively in @entity1673 and AS2 in equal numbers. This study demonstrates that preload correction is important in a preoperative assessment of contractility in aortic and @entity339 but that it is less important postoperatively, presumably because of reductions in the preload.

title: Correction for preload in assessment of myocardial contractility in aortic and @entity339 . Application of the concept of systolic XXXX .

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial stiffness']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral valve disease', 'mitral regurgitation']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic insufficiency']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity123 :: ('MESH:D024741', 'Disease') :: ['ventricular hypertrophy']

entities_list: @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic stenosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['coronary or cardiovascular disease']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial stiffness']


abstract: With single-beat analysis, the new concept of systolic @entity296 is applied to provide a new approach for the assessment of myocardial contractility in aortic and @entity339 . Seventy @entity1 underwent diagnostic right and left heart catheterization. Twenty-six @entity1 had @entity472 , 18 had @entity337 , and 26 had @entity339 . @entity1 with @entity472 were divided into two groups on the basis of left ventricular mass index less than 172 g/m2 ( @entity1673 ) and mass index greater than or equal to 172 g/m2 (AS2). The @entity339 @entity1 were divided into those in normal sinus rhythm ( @entity29817 ) and those in @entity955 (MR2). Nine @entity1 without significant @entity65 served as controls. Thirteen @entity1 with @entity472 and eight with @entity337 were evaluated (average, approximately 18 months) after successful aortic valve replacement. With simultaneous left ventricular pressure and cineangiographic methods, myocardial contractility was assessed by the conventional ejection fraction-afterload relation (uncorrected for preload) and by two new methods that permit the correction of the ejection fraction for preload. Assessments of the contractile state by these two new methods differed from those by the conventional method in 20-40% of the cases studied. Contractile state improved postoperatively in @entity472 and @entity337 even in @entity1 with preoperative depressed contractile states. In @entity1 with @entity339 , there was considerable heterogeneity of contractile function preoperatively. Severe left @entity123 in @entity472 was not a marker for postoperative outcome since contractility was normal postoperatively in @entity1673 and AS2 in equal numbers. This study demonstrates that preload correction is important in a preoperative assessment of contractility in aortic and @entity339 but that it is less important postoperatively, presumably because of reductions in the preload.

title: Correction for preload in assessment of myocardial contractility in aortic and XXXX . Application of the concept of systolic @entity296 .

answer: @entity339 :: (MESH:D008944,Disease) :: ['mitral valve disease']


abstract: We studied 19 young @entity1 (aged 15 to 39 months) who had had a @entity56 after imported fire ant (IFA) sting. Skin testing was performed with whole body extract (WBE) of both @entity39874 species; positive reactions to @entity15173 was noted in 94% and to @entity39874 in 100%. Serum was tested for total IgE level and for specific IgE antibodies by RAST with WBE and venom (V) of @entity15173 . In vitro results were compared with those of 19 age and sex-matched atopic control subjects. The range of total serum IgE level was 31 to 1720 IU/ml (geometric mean 160 IU/ml), compared with 7.5 to 6756 IU/ml (geometric mean 85 IU/ml) in the control subjects. The difference between the two groups, however, was not statistically significant (p greater than 0.05). In the IFA- @entity56 group, the IFA WBE RAST mean binding was 13.5% (range 2.0% to 30.2%), and the IFA V RAST mean was 29.2% (range 7.8% to 46.7%). The control sera demonstrated low levels of activity to both IFA WBE RAST (0.7% to 4.8%) and IFA V RAST (0.7% to 5.9%). IFA WBE RAST demonstrated that 26% of the IFA- @entity56 @entity1 had counts within the range of the atopic control subjects. In contrast, the IFA V RAST clearly separated all IFA- @entity56 @entity1 from their age and sex-matched atopic control subjects. A scoring system for IFA V RAST is proposed. These results demonstrate superiority of IFA V over IFA WBE RAST in the diagnosis of @entity566 to @entity15173 .

title: Imported fire ant XXXX in young @entity1 : skin reactivity and serum IgE antibodies to venom and whole body extract.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity39874 :: ('30203', 'Species') :: ['S. richteri', 'Solenopsis']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['systemic allergic reaction', 'allergic']

answer: @entity566 :: (MESH:D006967,Disease) :: ['allergy']


abstract: We studied 19 young @entity1 (aged 15 to 39 months) who had had a @entity56 after imported fire ant (IFA) sting. Skin testing was performed with whole body extract (WBE) of both @entity39874 species; positive reactions to @entity15173 was noted in 94% and to @entity39874 in 100%. Serum was tested for total IgE level and for specific IgE antibodies by RAST with WBE and venom (V) of @entity15173 . In vitro results were compared with those of 19 age and sex-matched atopic control subjects. The range of total serum IgE level was 31 to 1720 IU/ml (geometric mean 160 IU/ml), compared with 7.5 to 6756 IU/ml (geometric mean 85 IU/ml) in the control subjects. The difference between the two groups, however, was not statistically significant (p greater than 0.05). In the IFA- @entity56 group, the IFA WBE RAST mean binding was 13.5% (range 2.0% to 30.2%), and the IFA V RAST mean was 29.2% (range 7.8% to 46.7%). The control sera demonstrated low levels of activity to both IFA WBE RAST (0.7% to 4.8%) and IFA V RAST (0.7% to 5.9%). IFA WBE RAST demonstrated that 26% of the IFA- @entity56 @entity1 had counts within the range of the atopic control subjects. In contrast, the IFA V RAST clearly separated all IFA- @entity56 @entity1 from their age and sex-matched atopic control subjects. A scoring system for IFA V RAST is proposed. These results demonstrate superiority of IFA V over IFA WBE RAST in the diagnosis of @entity566 to @entity15173 .

title: Imported fire ant @entity566 in young XXXX : skin reactivity and serum IgE antibodies to venom and whole body extract.

answer: @entity1 :: (9606,Species) :: ['children']


abstract: A new periacetabular osteotomy of the pelvis has been used for the treatment of residual @entity572 in adolescents and adults. The identification of the joint capsule is performed through a Smith-Petersen approach, which also permits all osteotomies to be performed about the acetabulum. This osteotomy does not change the diameter of the true pelvis, but allows an extensive acetabular reorientation including medial and lateral displacement. Preparations and injections of the vessels of the hip joint on cadavers have shown that the osteotomized fragment perfusion after correction is sufficient. Because the posterior pillar stays mechanically intact the acetabular fragment can be stabilized sufficiently using two screws. This stability allows @entity1 to partially bear weight after osteotomy without immobilization. Since 1984, 75 periacetabular osteotomies of the hip have been performed. The corrections are 31 degrees for the vertical center-edge (VCE) angle of Wiberg and 26 degrees for the corresponding angle of Lequesne and de Seze in the sagittal plane. Complications have included two @entity7334 , a @entity2096 that resolved, one nonunion, and ectopic bone formation in four @entity1 prior to the prophylactic use of @entity3352 . Thirteen @entity1 required screw removal. There was no evidence of @entity455 of the osteotomized fragment.

title: A new periacetabular osteotomy for the treatment of XXXX . Technique and preliminary results.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular impairment']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['hip dysplasias']

entities_list: @entity7334 :: ('MESH:D057072', 'Disease') :: ['intraarticular osteotomies']

entities_list: @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin']

entities_list: @entity2096 :: ('MESH:D020428', 'Disease') :: ['femoral nerve palsy']

answer: @entity572 :: (MESH:D006617,Disease) :: ['hip dysplasias']