abstract: In revision total hip arthroplasty (THA), consensus is lacking regarding the optimal method for reconstruction of the most severe @entity7195 . Porous @entity11608 (TM) buttress augments were designed for the most severe postero-superior defects. The purpose of this study was to report the results of a consecutive series of acetabular reconstructions utilizing TM buttress augments. Eight complex acetabular reconstructions utilizing a TM buttress augment were performed at two centers. All were Paprosky 3A or Paprosky 3B @entity604 , with severe superior and posterior column deficiency where wedge augments were insufficient for mechanical support. The acetabular cup sizes ranged from 64-78, and a buttress shim was used in 7 of 8 cases. Clinical and radiographic follow-up averaged 16.5 months (range, 10-28) and no cases were lost to follow-up. There were no cases of clinical or radiographic loosening, and no case had required reoperation or revision. All @entity1 except one were ambulating with either no assist device or a single cane at final follow-up. There was one complication of an iliac wing @entity174 noted incidentally on postoperative x-rays in the lone @entity1 in whom a buttress shim was not used. At short-term follow-up, TM acetabular buttress augments appear to effectively substitute for the use of structural allografts or cages, which would otherwise be used in this challenging setting. The potential for biologic fixation is promising for the durability of these reconstructions; however, longer-term follow-up is required for full evaluation.

title: Porous XXXX Buttress Augments for Severe Acetabular Posterior Column Deficiency.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity7195 :: ('OMIM:142700', 'Disease') :: ['acetabular defects']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss classification']

answer: @entity11608 :: (MESH:D013635,Chemical) :: ['Tantalum']


abstract: OBJECTIVE: To compare the @entity410 and developmental outcomes in @entity1 and young @entity1 with @entity302 who have undergone surgical and medical treatments. METHODS: An international, multicenter, observational cohort study was undertaken. A total of 317 @entity1 aged <6years, who had frequent disabling @entity410 despite intensive medical treatments, were registered. Among the enrolled @entity1 , 250 were treated medically (medical group), 31 underwent resective surgery (resective group), and 36 underwent palliative surgery [callosotomy (n=30) or vagal nerve stimulation (n=6); palliative group] on admission. @entity410 and developmental outcomes were obtained for 230 @entity1 during the 3-year follow-up period. Cox proportional hazard model was used to adjust for clinical backgrounds among treatment groups when comparing the @entity410 -free survival rates. RESULTS: At the 3-year follow-up, @entity410 -free survival was 15.7%, 32.1%, and 52.4% in the medical, palliative, and resective groups, respectively. The adjusted hazard ratios for @entity410 recurrence in the resective and palliative groups versus the medical group were 0.43 (95% CI, 0.21-0.87, P=0.019) and 0.82 (95% CI, 0.46-1.46, P=0.50), respectively; the former was statistically significant. Regarding the developmental outcome, the mean DQs in the resective group increased significantly compared to those in the medical group during the follow-up (P<0.01). As for subgroup analysis, better @entity410 and development outcomes were demonstrated in the resective group compared to the medical group in @entity1 with @entity302 (those to which no known @entity302 syndromes were applicable). SIGNIFICANCE: These results suggest that surgical treatments, particularly resective surgeries, are associated with better @entity410 and developmental outcomes compared with successive medical treatment. The present observations may facilitate the identification of @entity1 and young @entity1 with @entity302 who could benefit from surgery.

title: Surgical versus medical treatment for @entity1 with XXXX in infancy and early childhood: Results of an international multicenter cohort study in Far-East Asia (the FACE study).

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'infants']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'Seizure']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic encephalopathy', 'epilepsy', 'nonsyndromic epilepsies']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epileptic encephalopathy']


abstract: OBJECTIVE: To compare the @entity410 and developmental outcomes in @entity1 and young @entity1 with @entity302 who have undergone surgical and medical treatments. METHODS: An international, multicenter, observational cohort study was undertaken. A total of 317 @entity1 aged <6years, who had frequent disabling @entity410 despite intensive medical treatments, were registered. Among the enrolled @entity1 , 250 were treated medically (medical group), 31 underwent resective surgery (resective group), and 36 underwent palliative surgery [callosotomy (n=30) or vagal nerve stimulation (n=6); palliative group] on admission. @entity410 and developmental outcomes were obtained for 230 @entity1 during the 3-year follow-up period. Cox proportional hazard model was used to adjust for clinical backgrounds among treatment groups when comparing the @entity410 -free survival rates. RESULTS: At the 3-year follow-up, @entity410 -free survival was 15.7%, 32.1%, and 52.4% in the medical, palliative, and resective groups, respectively. The adjusted hazard ratios for @entity410 recurrence in the resective and palliative groups versus the medical group were 0.43 (95% CI, 0.21-0.87, P=0.019) and 0.82 (95% CI, 0.46-1.46, P=0.50), respectively; the former was statistically significant. Regarding the developmental outcome, the mean DQs in the resective group increased significantly compared to those in the medical group during the follow-up (P<0.01). As for subgroup analysis, better @entity410 and development outcomes were demonstrated in the resective group compared to the medical group in @entity1 with @entity302 (those to which no known @entity302 syndromes were applicable). SIGNIFICANCE: These results suggest that surgical treatments, particularly resective surgeries, are associated with better @entity410 and developmental outcomes compared with successive medical treatment. The present observations may facilitate the identification of @entity1 and young @entity1 with @entity302 who could benefit from surgery.

title: Surgical versus medical treatment for XXXX with @entity302 in infancy and early childhood: Results of an international multicenter cohort study in Far-East Asia (the FACE study).

answer: @entity1 :: (9606,Species) :: ['children']


abstract: UNASSIGNED: Dystocias are common in dairy @entity291 and often adversely affect production, reproduction, animal welfare, labor, and economics within the dairy industry. An automated device that accurately predicts the onset of calving could potentially minimize the effect of @entity1266 by enabling producers to intervene early. Although many well-documented indicators can detect the imminence of calving, research is limited on their effectiveness to predict calving when measured by automated devices. The objective of this experiment was to determine if a decrease in vaginal temperature (VT), @entity3685 ( @entity3685 ), and lying time (LT), or an increase in lying bouts (LB), as measured by 3 automated devices, could accurately predict the onset of calving within 24, 12, and 6 h. The combination of these 4 calving indicators was also evaluated. Forty-two multiparous Holstein @entity291 housed in tie-stalls were fitted with a temperature logger inserted in the vaginal cavity 7    2 d before their expected calving date; VT was recorded at 1-min intervals. An ear-attached sensor recorded @entity3685 time every hour based on ear movement while an accelerometer fitted to the right hind leg recorded @entity291 position at 1-min intervals. On average, VT were 0.3    0.03  C lower, and @entity3685 and LT were 41    17 and 52    28 min lower, respectively, on the calving day compared with the previous 4 @entity291 had 2    1 more LB on the calving day. Of the 4 indicators, a decrease in VT >=  0.1  C was best able to predict calving within the next 24 h with a sensitivity of 74%, specificity of 74%, positive and negative predictive values of 51 and 89%, and area under the curve of 0.80. Combining the indicators enhanced the performance to predict calving within the next 24, 12, and 6 h with best overall results obtained by combining the 3 devices for prediction within the next 24 h (sensitivity: 77%, specificity: 77%, positive and negative predictive values: 56 and 90%, area under the curve: 0.82). These results indicate that a device that could simultaneously measure these 4 calving indicators could not precisely determine the onset of calving, but the information collected would assist dairy farmers in monitoring the onset of calving.

title: Evaluation of calving indicators measured by automated monitoring devices to predict the onset of calving in Holstein dairy XXXX .

entities_list: @entity3685 :: ('MESH:D019959', 'Disease') :: ['RT', 'rumination']

entities_list: @entity1266 :: ('MESH:D004420', 'Disease') :: ['dystocias']

answer: @entity291 :: (9913,Species) :: ['cows']


abstract: BACKGROUND: Mortality for refractory @entity1455 remains high. In this @entity1 cohort, there have been mixed results in mechanical circulatory support device use as a bridge-to-decision therapy. We evaluated a continuous-flow external ventricular assist device (VAD), CentriMag VAD (Thoratec Corp., Pleasanton, CA), in @entity1 with various causes of refractory @entity1455 . METHODS AND RESULTS: This is a retrospective review of adult @entity1 who underwent surgical CentriMag VAD insertion as bridge-to-decision therapy. From January 2007 through June 2012, 143 @entity1 received CentriMag VAD. The cause of refractory @entity1455 was failure of medical management in 71 @entity1 , @entity1457 in 37, graft failure post-heart transplantation in 22, and @entity67 post-implantable left VAD in 13. Mean age was 52  16 years, and 71% were in INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) profile 1. Among 158 device runs, device configuration was BiVAD in 67%, isolated right VAD in 26%, and isolated left VAD in 8%. Median duration of support was 14 days (interquartile range, 8-26). Survival was 69% at 30 days and 49% at 1 year. The next destination after the CentriMag VAD was myocardial recovery in 30%, device exchange to an implantable VAD in 15%, and heart transplantation in 18%. The failure of medical management and the graft failure post-heart transplantation groups had higher 30-day survival compared with the @entity1457 group. Major @entity548 events occurred in 33% and cerebrovascular accidents in 14%. There was no CentriMag pump failure or @entity715 . CONCLUSIONS: Bridge-to-decision therapy with CentriMag VAD is feasible in a variety of refractory @entity1455 settings. @entity1 with @entity1457 have inferior survival.

title: Bridge-to-decision therapy with a continuous-flow external ventricular assist device in refractory XXXX of various causes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['postcardiotomy shock']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['right ventricular failure']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

answer: @entity1455 :: (MESH:D012770,Disease) :: ['cardiogenic shock']


abstract: BACKGROUND: National data demonstrate minimal improvement in survival for @entity1 diagnosed with @entity2 despite a number of apparent advances during the past 3 decades. We wished to know how demographic characteristics, staging, therapy, and survival have changed over time for @entity1 with @entity2 who were accessioned to the @entity5 registry of a large community hospital in southern California. @entity1 AND METHODS: Clinical features and survival data were collected on @entity1 diagnosed during each of the successive 6-year eras of 1986 to 1991 (n = 812), 1992 to 1997 (n = 1072), 1998 to 2003 (n = 1209), and 2004 to 2009 (n = 1365). RESULTS: Median survival improved from 11 to 13 to 16 to 26 months and overall 5-year survival steadily improved from 16.5% to 19.1% to 24.0% to 31.1%. The proportion of @entity1 with @entity66 at diagnosis increased from 18.4% to 24.1% to 24.9% to 31.6%. Improvements in relative survival were much greater than have occurred nationally. Other obvious trends over time were increasing age of @entity1 , increasing proportions with diagnoses of @entity420 with concomitant decreases in squamous cell and small cell histologies, and decreases in the proportion of @entity152 with reciprocal increases in neuroendocrine diagnoses. The use of chemotherapy for @entity1 with @entity66 tripled in the most recent era. CONCLUSION: Survival has steadily improved for @entity1 in this community who were diagnosed with @entity2 . The explanations for this improvement are multifactorial, but include earlier stage at diagnosis, decreases in histologic types associated with active smoking, and increased use of systemic therapies.

title: Steadily improving survival in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['localized disease', 'local disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity152 :: ('MESH:D018287', 'Disease') :: ['large cell carcinoma']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: OBJECTIVE: To compare the initial clinical, biological, and radiographic findings of @entity625 by positivity for rheumatoid factor (RF) and/or anticyclic citrullinated peptide antibodies (anti-CCP), and to validate a @entity1 profile based on this serologic information. METHODS: The ESPOIR cohort comprises @entity1 presenting @entity603 of at least 2 joints for 6 weeks to 6 months. @entity1 underwent testing for IgM rheumatoid factor (IgM-RF) and anti- @entity14965 antibodies and were divided into 4 groups: RF- and anti-CCP- (group 1), RF+ and anti-CCP- (group 2), RF- and anti-CCP+ (group 3), RF+ and anti-CCP+ (group 4). We compared the groups in terms of clinical, biological, and radiographic features (baseline scores and 6-month and 12-month progression). RESULTS: Of the 813 recruited @entity1 , 406 (50%) were in group 1, 91 (11.2%) in group 2, 34 (4.1%) in group 3, and 281 (34.6%) in group 4. Mean baseline erythrocyte sedimentation rate and @entity1851 were higher for anti-CCP+ groups (groups 3 and 4) than for other groups (p < 0.001), and van der Heijde-modified Sharp score for radiographs was higher for group 4 than for other groups (p < 0.001). Clinical presentation was not consistently associated with serologic profile. Radiographic progression at 1 year was higher for anti-CCP+ groups than other groups (p < 0.001). CONCLUSION: The phenotype of @entity1 with @entity625 with or without anti-CCP and/or RF positivity did not correspond to a particular clinical presentation. However, baseline acute-phase reactants and short-term radiographic progression were high in patients with anti-CCP positivity, which may be associated with the inflammatory process and @entity74 in @entity1 with @entity625 .

title: Association of anticyclic citrullinated peptide antibodies and/or rheumatoid factor status and clinical presentation in XXXX : results from the ESPOIR cohort.

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['early arthritis']

entities_list: @entity603 :: ('MESH:D013585', 'Disease') :: ['synovitis']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['progressive disease']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity625 :: (MESH:D001168,Disease) :: ['early arthritis']


abstract: PURPOSE: The social needs of nursing home (NH) residents with @entity303 are often ignored even though they are capable of expressing their emotions and responding in social interactions. Insufficient social engagement in this population is known to be associated with low quality of life as well as many negative health outcomes, such as mortality, @entity2146 , and functional decline. The purpose of this study was to identify the correlates of social engagement in NH residents with @entity303 . METHODS: The study used a descriptive, correlational design. A total of 153 older adults with @entity303 in 17 Iowa NHs participated in this study. Minimum Data Set for NH version 2.0 served as an outcome measure to evaluate social engagement, cognitive and physical functions, @entity308 , and behavioral symptoms. Demographic data were obtained from the @entity1 ' medical records. RESULTS: The findings indicated that no significant relationship was found between demographic characteristics and social engagement. There were significant and negative correlations between the degree of social engagement and the levels of @entity73 , activities of daily living impairment, @entity308 , and vision. Among these correlates, @entity308 was the most potent predictor of engagement. CONCLUSION: The study provided information about the correlates of social engagement in NH residents with @entity303 . Future research needs to be conducted to develop nursing interventions to involve these individuals in social activities tailored to functional levels, and @entity308 in more diverse geographic regions.

title: Correlates of social engagement in nursing home residents with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation']

answer: @entity303 :: (MESH:D003704,Disease) :: ['dementia']


abstract: Mutation is associated with developmental and @entity74 , aging, and @entity5 . While we understand some mutational processes operative in @entity1 disease, most remain mysterious. We used @entity2199 whole-genome sequencing to model mutational signatures, analyzing 183 worm populations across 17 DNA repair-deficient backgrounds propagated for 20 generations or exposed to carcinogens. The baseline mutation rate in @entity2199 was approximately one per genome per generation, not overtly altered across several DNA repair deficiencies over 20 generations. Telomere erosion led to complex chromosomal rearrangements initiated by breakage-fusion-bridge cycles and completed by simultaneously acquired, localized clusters of breakpoints. @entity4078 induced substitutions of guanines in a GpC context, as observed in @entity11189 -induced @entity96 . Mutational burden increased with impaired @entity377 excision repair. @entity900 and @entity3700 , DNA crosslinking agents, caused dose- and genotype-dependent signatures among indels, substitutions, and rearrangements. Strikingly, both agents induced clustered rearrangements resembling "chromoanasynthesis," a replication-based mutational signature seen in constitutional genomic disorders, suggesting that interstrand crosslinks may play a pathogenic role in such events. @entity900 mutagenicity was most pronounced in xpf-1 mutants, suggesting that this gene critically protects cells against @entity902 chemotherapy. Thus, experimental model systems combined with genome sequencing can recapture and mechanistically explain mutational signatures associated with @entity1 disease.

title: XXXX whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency.

entities_list: @entity2199 :: ('6239', 'Species') :: ['C. elegans', 'Caenorhabditis elegans']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cancers']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['Cisplatin']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['hereditary disorders']

entities_list: @entity4078 :: ('MESH:D016604', 'Chemical') :: ['Aflatoxin B1']

entities_list: @entity11189 :: ('MESH:D000348', 'Chemical') :: ['aflatoxin']

entities_list: @entity3700 :: ('MESH:D008466', 'Chemical') :: ['mechlorethamine']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity2199 :: (6239,Species) :: ['C. elegans']


abstract: Purpose To evaluate the diagnostic performance of three-dimensional ( 3D three-dimensional ) quantitative enhancement-based and diffusion-weighted volumetric magnetic resonance (MR) imaging assessment of @entity157 ( @entity157 ) lesions in determining the extent of pathologic @entity39 ( @entity3375 transarterial chemoembolization ). Materials and Methods This institutional review board-approved retrospective study included 17 @entity1 with @entity157 who underwent @entity3375 transarterial chemoembolization before surgery. Semiautomatic 3D three-dimensional volumetric segmentation of target lesions was performed at the last MR examination before orthotopic liver transplantation or surgical resection. The amount of @entity5 tissue on contrast material-enhanced arterial phase MR images and the amount of diffusion-restricted @entity5 tissue on apparent diffusion coefficient ( ADC apparent diffusion coefficient ) maps were expressed as a percentage of the total @entity5 volume. Visual assessment of the extent of @entity5 @entity39 and @entity5 response according to European Association for the Study of the Liver ( EASL European Association for the Study of the Liver ) criteria was performed. Pathologic @entity5 @entity39 was quantified by using slide-by-slide segmentation. Correlation analysis was performed to evaluate the predictive values of the radiologic techniques. Results At histopathologic examination, the mean percentage of @entity5 @entity39 was 70% (range, 10%-100%). Both 3D three-dimensional quantitative techniques demonstrated a strong correlation with @entity5 @entity39 at pathologic examination (R(2) = 0.9657 and R(2) = 0.9662 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively) and a strong intermethod agreement (R(2) = 0.9585). Both methods showed a significantly lower discrepancy with pathologically measured @entity39 (residual standard error [ RSE residual standard error ] = 6.38 and 6.33 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively), when compared with non- 3D three-dimensional techniques ( RSE residual standard error = 12.18 for visual assessment). Conclusion This radiologic-pathologic correlation study demonstrates the diagnostic accuracy of 3D three-dimensional quantitative MR imaging techniques in identifying pathologically measured @entity5 @entity39 in @entity157 lesions treated with @entity3375 transarterial chemoembolization .    RSNA, 2014 Online supplemental material is available for this article.

title: Radiologic-Pathologic Analysis of Contrast-enhanced and Diffusion-weighted MR Imaging in @entity1 with HCC after XXXX : Diagnostic Accuracy of 3D Quantitative Image Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'tumor necrosis after transarterial chemoembolization']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'necrotic tumor']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC hepatocellular carcinoma', 'hepatocellular carcinoma']

answer: @entity3375 :: (6868,Gene) :: ['TACE']


abstract: Purpose To evaluate the diagnostic performance of three-dimensional ( 3D three-dimensional ) quantitative enhancement-based and diffusion-weighted volumetric magnetic resonance (MR) imaging assessment of @entity157 ( @entity157 ) lesions in determining the extent of pathologic @entity39 ( @entity3375 transarterial chemoembolization ). Materials and Methods This institutional review board-approved retrospective study included 17 @entity1 with @entity157 who underwent @entity3375 transarterial chemoembolization before surgery. Semiautomatic 3D three-dimensional volumetric segmentation of target lesions was performed at the last MR examination before orthotopic liver transplantation or surgical resection. The amount of @entity5 tissue on contrast material-enhanced arterial phase MR images and the amount of diffusion-restricted @entity5 tissue on apparent diffusion coefficient ( ADC apparent diffusion coefficient ) maps were expressed as a percentage of the total @entity5 volume. Visual assessment of the extent of @entity5 @entity39 and @entity5 response according to European Association for the Study of the Liver ( EASL European Association for the Study of the Liver ) criteria was performed. Pathologic @entity5 @entity39 was quantified by using slide-by-slide segmentation. Correlation analysis was performed to evaluate the predictive values of the radiologic techniques. Results At histopathologic examination, the mean percentage of @entity5 @entity39 was 70% (range, 10%-100%). Both 3D three-dimensional quantitative techniques demonstrated a strong correlation with @entity5 @entity39 at pathologic examination (R(2) = 0.9657 and R(2) = 0.9662 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively) and a strong intermethod agreement (R(2) = 0.9585). Both methods showed a significantly lower discrepancy with pathologically measured @entity39 (residual standard error [ RSE residual standard error ] = 6.38 and 6.33 for quantitative EASL European Association for the Study of the Liver and quantitative ADC apparent diffusion coefficient , respectively), when compared with non- 3D three-dimensional techniques ( RSE residual standard error = 12.18 for visual assessment). Conclusion This radiologic-pathologic correlation study demonstrates the diagnostic accuracy of 3D three-dimensional quantitative MR imaging techniques in identifying pathologically measured @entity5 @entity39 in @entity157 lesions treated with @entity3375 transarterial chemoembolization .    RSNA, 2014 Online supplemental material is available for this article.

title: Radiologic-Pathologic Analysis of Contrast-enhanced and Diffusion-weighted MR Imaging in XXXX with HCC after @entity3375 : Diagnostic Accuracy of 3D Quantitative Image Analysis.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: PURPOSE: To evaluate whether adding a contrast-enhanced fluid-attenuated inversion recovery (FLAIR) sequence to routine magnetic resonance imaging (MRI) can detect additional abnormalities in the brains of symptomatic @entity1 with mild @entity131 . MATERIALS AND METHODS: Fifty-four @entity1 with persistent symptoms following mild @entity6075 were included in our retrospective study (M     F = 32     22, mean age: 59.8    16.4, age range: 26-84 years). All MRI examinations were obtained within 14 days after @entity542 (mean: 3.2    4.1 days, range: 0.2-14 days). Two neuroradiologists recorded (1) the presence of traumatic @entity75 on MR images with and without contrast-enhanced FLAIR images and (2) the pattern and location of meningeal enhancement depicted on contrast-enhanced FLAIR images. The number of additional traumatic @entity75 diagnosed with contrast-enhanced FLAIR was recorded. Correlations between meningeal enhancement and clinical findings were also evaluated. RESULTS: Traumatic @entity75 were detected on routine image sequences in 25 @entity1 . Three additional cases of @entity75 were detected with the contrast-enhanced FLAIR images. Meningeal enhancement was identified on contrast-enhanced FLAIR images in 9 cases while the other routine image sequences showed no findings of @entity131 . Overall, the additional contrast-enhanced FLAIR images revealed more extensive abnormalities than routine imaging in 37 cases (p<0.001). In multivariate logistic regression analysis, subdural @entity1410 and @entity909 showed a significant association with meningeal enhancement on contrast-enhanced FLAIR images, with odds ratios 13.068 (95% confidence interval 2.037 to 83.852), and 15.487 (95% confidence interval 2.545 to 94.228), respectively. CONCLUSION: Meningeal enhancement on contrast-enhanced FLAIR images can help detect traumatic @entity75 as well as additional abnormalities not identified on routine unenhanced MRI. Therefore contrast-enhanced FLAIR MR imaging is recommended when a contrast MR study is indicated in a @entity1 with a symptomatic prior closed mild @entity542 .

title: Contrast-enhanced FLAIR (fluid-attenuated inversion recovery) for evaluating mild XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain abnormality', 'brain lesions']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head trauma', 'head injury']

entities_list: @entity909 :: ('MESH:D014474', 'Disease') :: ['posttraumatic loss of consciousness']

entities_list: @entity6075 :: ('MESH:D016489', 'Disease') :: ['closed head injury']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: OBJECTIVE: The aim of this study was to evaluate the efficacy and safety of anterior cervical corpectomy and fusion (ACCF) and anterior cervical discectomy and fusion (ACDF) for treating two-adjacent-level @entity4720 ( @entity4720 ). DESIGN: A meta-analysis of the two anterior fusion methods was conducted. The electronic databases of PubMed, the Cochrane Central Register of Controlled Trials, ScienceDirect, CNKI, WANFANG DATA and CQVIP were searched. Quality assessment of the included studies was evaluated using the Cochrane Risk of Bias Tool and the Methodological Index for Non-Randomised Studies criteria. Pooled risk ratios of dichotomous outcomes and standardised mean differences (SMDs) of continuous outcomes were generated. Using the   (2) and I(2) tests, the statistical heterogeneity was assessed. Subgroup and sensitivity analyses were also performed. @entity1 : Nine eligible trials with a total of 631 @entity1 and a male-to-female ratio of 1.38:1 were included in this meta-analysis. INCLUSION CRITERIA: Randomised controlled trials (RCTs) and non-randomised controlled trials that adopted ACCF and ACDF to treat two-adjacent-level @entity4720 were included. RESULTS: No significant differences were identified between the two groups regarding hospital stay, the Japanese Orthopaedic Association (JOA) score, visual analogue scale (VAS) scores for neck and arm @entity158 (ROM), fusion ROM, fusion rate, adjacent-level ossification and complications, while ACDF had significantly less @entity548 ( @entity7126 =1.14, 95% CI (0.74 to 1.53)); a shorter operation time ( @entity7126 =1.13, 95% CI (0.82 to 1.45)); greater cervical @entity1515 , total cervical ( @entity7126 =-2.95, 95% CI (-4.79 to -1.12)) and fused segment ( @entity7126 =-2.24, 95% CI (-3.31 to -1.17)); higher segmental height ( @entity7126 =-0.68, 95% CI (-1.03 to -0.34)) and less graft subsidence ( @entity7126 =0.40, 95% CI (0.06 to 0.75)) compared to ACCF. CONCLUSIONS: The results suggested that ACDF has more advantages compared to ACCF. However, additional high-quality RCTs and a longer follow-up duration are needed.

title: Comparison of two anterior fusion methods in two-level XXXX : a meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain, total cervical range of motion']

entities_list: @entity4720 :: ('MESH:D055009', 'Disease') :: ['CSM', 'cervical spondylosis myelopathy']

answer: @entity4720 :: (MESH:D055009,Disease) :: ['cervical spondylosis myelopathy']


abstract: OBJECTIVE: To relate neurophysiologic changes after mild/moderate @entity131 to @entity73 in a longitudinal diffusion tensor imaging investigation. METHODS: Fifty-three @entity1 were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three @entity1 were rescanned 1 year later. Thirty-three matched control subjects were recruited. At the time of scanning, @entity1 completed cognitive testing. Tract-Based Spatial Statistics was used to conduct voxel-wise analysis on diffusion changes and to explore regressions between diffusion metrics and cognitive performance. RESULTS: Acutely, increased axial diffusivity drove a fractional anisotropy (FA) increase, while decreased radial diffusivity drove a negative regression between FA and Verbal Letter Fluency across widespread white matter regions, but particularly in the ascending fibers of the corpus callosum. Raised FA is hypothesized to be caused by astrogliosis and compaction of axonal neurofilament, which would also affect cognitive functioning. Chronically, FA was decreased, suggesting @entity17 , but still regressed negatively with Verbal Letter Fluency in the anterior forceps. CONCLUSIONS: Acute mild/moderate @entity131 is characterized by increased tissue FA, which represents a clear neurobiological link between @entity73 and @entity62 after mild/moderate injury.

title: White matter correlates of @entity73 after mild XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity17 :: ('MESH:D003711', 'Disease') :: ['myelin sheath disintegration']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficit', 'cognitive dysfunction']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter injury']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: OBJECTIVE: To relate neurophysiologic changes after mild/moderate @entity131 to @entity73 in a longitudinal diffusion tensor imaging investigation. METHODS: Fifty-three @entity1 were scanned an average of 6 days postinjury (range = 1-14 days). Twenty-three @entity1 were rescanned 1 year later. Thirty-three matched control subjects were recruited. At the time of scanning, @entity1 completed cognitive testing. Tract-Based Spatial Statistics was used to conduct voxel-wise analysis on diffusion changes and to explore regressions between diffusion metrics and cognitive performance. RESULTS: Acutely, increased axial diffusivity drove a fractional anisotropy (FA) increase, while decreased radial diffusivity drove a negative regression between FA and Verbal Letter Fluency across widespread white matter regions, but particularly in the ascending fibers of the corpus callosum. Raised FA is hypothesized to be caused by astrogliosis and compaction of axonal neurofilament, which would also affect cognitive functioning. Chronically, FA was decreased, suggesting @entity17 , but still regressed negatively with Verbal Letter Fluency in the anterior forceps. CONCLUSIONS: Acute mild/moderate @entity131 is characterized by increased tissue FA, which represents a clear neurobiological link between @entity73 and @entity62 after mild/moderate injury.

title: White matter correlates of XXXX after mild @entity131 .

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive dysfunction']


abstract: BACKGROUND: Newer approaches to mammography, including digital image acquisition and computer-aided detection (CAD), and adjunct imaging (e.g., magnetic resonance imaging [MRI]) have diffused into clinical practice. The impact of these technologies on screening-related cost and outcomes remains undefined, particularly among older @entity1 . METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare linked database, we constructed two cohorts of @entity1 without a history of @entity0 and followed each cohort for 2 years. We compared the use and cost of screening mammography including digital mammography and CAD, adjunct procedures including breast ultrasound, MRI, and biopsy between the period of 2001 and 2002 and the period of 2008 and 2009 using   (2) and t test. We also assessed the change in @entity0 stage and incidence rates using   (2) and Poisson regression. All statistical tests were two-sided. RESULTS: There were 137150 @entity1 (mean age = 76.0 years) in the early cohort (2001-2002) and 133097 @entity1 (mean age = 77.3 years) in the later cohort (2008-2009). The use of digital image acquisition for screening mammography increased from 2.0% in 2001 and 2002 to 29.8% in 2008 and 2009 (P < .001). CAD use increased from 3.2% to 33.1% (P < .001). Average screening-related cost per capita increased from  76 to  112 (P < .001), with annual national fee-for-service Medicare spending increasing from  666 million to  962 million. There was no statistically significant change in detection rates of early-stage @entity5 (2.45 vs 2.57 per 1000 @entity1 -years; P = .41). CONCLUSIONS: Although @entity0 screening-related costs increased substantially from 2001 through 2009 among Medicare beneficiaries, a clinically significant change in stage at diagnosis was not observed.

title: Evolution of XXXX screening in the Medicare population: clinical and economic implications.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'person']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: @entity167 directly modulates the BK @entity972 channel to alter behaviors in species ranging from invertebrates to @entity1 . In the @entity2199 @entity2199 , mutations that eliminate the BK channel, @entity70798 , convey dramatic resistance to intoxication by @entity1068 . We hypothesized that certain conserved @entity1522 are critical for @entity1068 modulation, but not for basal channel function. To identify such residues, we screened @entity2199 strains with different missense mutations in the @entity70798 channel. A strain with the @entity70798 missense mutation @entity70799 in the RCK1 domain was highly resistant to intoxication. This mutation did not interfere with other BK channel-dependent behaviors, suggesting that the mutant channel retained normal in vivo function. Knock-in of wild-type versions of the worm or @entity1 BK channel rescued intoxication and other BK channel-dependent behaviors in a @entity4030 -null mutant background. In contrast, knock-in of the worm @entity70799 or equivalent @entity1 @entity70800 mutant BK channel selectively rescued BK channel-dependent behaviors while conveying resistance to intoxication. Single-channel patch-clamp recordings confirmed that the @entity1 BK channel engineered with the @entity70800 missense mutation was insensitive to activation by @entity1068 , but otherwise had normal conductance, @entity972 selectivity, and only subtle differences in voltage dependence. Together, our behavioral and electrophysiological results demonstrate that the @entity70800 mutation selectively disrupts @entity1068 modulation of the BK channel. The @entity70800 mutation may alter a binding site for @entity1068 and/or interfere with @entity1068 -induced conformational changes that are critical for behavioral responses to @entity1068 .

title: Conserved single residue in the BK @entity972 channel required for activation by XXXX and intoxication in @entity2199 .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity2199 :: ('6239', 'Species') :: ['nematode', 'C. elegans', 'Caenorhabditis elegans']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['Alcohol']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']


abstract: @entity167 directly modulates the BK @entity972 channel to alter behaviors in species ranging from invertebrates to @entity1 . In the @entity2199 @entity2199 , mutations that eliminate the BK channel, @entity70798 , convey dramatic resistance to intoxication by @entity1068 . We hypothesized that certain conserved @entity1522 are critical for @entity1068 modulation, but not for basal channel function. To identify such residues, we screened @entity2199 strains with different missense mutations in the @entity70798 channel. A strain with the @entity70798 missense mutation @entity70799 in the RCK1 domain was highly resistant to intoxication. This mutation did not interfere with other BK channel-dependent behaviors, suggesting that the mutant channel retained normal in vivo function. Knock-in of wild-type versions of the worm or @entity1 BK channel rescued intoxication and other BK channel-dependent behaviors in a @entity4030 -null mutant background. In contrast, knock-in of the worm @entity70799 or equivalent @entity1 @entity70800 mutant BK channel selectively rescued BK channel-dependent behaviors while conveying resistance to intoxication. Single-channel patch-clamp recordings confirmed that the @entity1 BK channel engineered with the @entity70800 missense mutation was insensitive to activation by @entity1068 , but otherwise had normal conductance, @entity972 selectivity, and only subtle differences in voltage dependence. Together, our behavioral and electrophysiological results demonstrate that the @entity70800 mutation selectively disrupts @entity1068 modulation of the BK channel. The @entity70800 mutation may alter a binding site for @entity1068 and/or interfere with @entity1068 -induced conformational changes that are critical for behavioral responses to @entity1068 .

title: Conserved single residue in the BK @entity972 channel required for activation by @entity167 and intoxication in XXXX .

answer: @entity2199 :: (6239,Species) :: ['C. elegans']


abstract: @entity167 directly modulates the BK @entity972 channel to alter behaviors in species ranging from invertebrates to @entity1 . In the @entity2199 @entity2199 , mutations that eliminate the BK channel, @entity70798 , convey dramatic resistance to intoxication by @entity1068 . We hypothesized that certain conserved @entity1522 are critical for @entity1068 modulation, but not for basal channel function. To identify such residues, we screened @entity2199 strains with different missense mutations in the @entity70798 channel. A strain with the @entity70798 missense mutation @entity70799 in the RCK1 domain was highly resistant to intoxication. This mutation did not interfere with other BK channel-dependent behaviors, suggesting that the mutant channel retained normal in vivo function. Knock-in of wild-type versions of the worm or @entity1 BK channel rescued intoxication and other BK channel-dependent behaviors in a @entity4030 -null mutant background. In contrast, knock-in of the worm @entity70799 or equivalent @entity1 @entity70800 mutant BK channel selectively rescued BK channel-dependent behaviors while conveying resistance to intoxication. Single-channel patch-clamp recordings confirmed that the @entity1 BK channel engineered with the @entity70800 missense mutation was insensitive to activation by @entity1068 , but otherwise had normal conductance, @entity972 selectivity, and only subtle differences in voltage dependence. Together, our behavioral and electrophysiological results demonstrate that the @entity70800 mutation selectively disrupts @entity1068 modulation of the BK channel. The @entity70800 mutation may alter a binding site for @entity1068 and/or interfere with @entity1068 -induced conformational changes that are critical for behavioral responses to @entity1068 .

title: Conserved single residue in the BK XXXX channel required for activation by @entity167 and intoxication in @entity2199 .

answer: @entity972 :: (MESH:D011188,Chemical) :: ['potassium']


abstract: UNASSIGNED: Essentials Elastic compression stocking (ECS) therapy is used to prevent @entity715 ( @entity715 ). We aimed to elicit @entity1 preferences regarding ECS therapy after @entity1150 . The most valued attributes were @entity715 risk reduction and the ability to put on the ECS independently. Heterogeneous results with respect to education level stress the importance of proper counselling. SUMMARY: Background Elastic compression stocking (ECS) therapy is used for prevention of @entity715 ( @entity715 ) after @entity1150 ( @entity1150 ). Current evidence on its effectiveness is conflicting. Compliance, a major determinant of the effectiveness of ECS therapy, remained largely ignored in former studies. Objectives To gain insight into preferences regarding ECS therapy in @entity1 after @entity1150 . @entity1 /methods A discrete choice experiment was conducted 3 months after @entity1150 in @entity1 enrolled in the IDEAL @entity1150 study, a randomized controlled trial comparing 2 years of ECS therapy with individually tailored duration of ECS therapy for the prevention of @entity715 . Nine unlabeled, forced-choice sets of two hypothetical types of ECS were presented to each @entity1 . Data were analyzed with multinomial logit models. Results The respondent sample consisted of 81% (300/369) of invited @entity1 . The most important determinants of preference were @entity715 risk reduction and putting on the ECS. @entity1 were willing to increase the duration of therapy by 1 year if this increases the @entity715 risk reduction with 10%. @entity1 accepted an increase in the risk of @entity715 of 29% if they were able to put on the ECS themselves. Preferences were heterogeneous with respect to education level. Conclusions Reduction of the risk of @entity715 and the ability to put on the ECS without help are the most important characteristics of ECS therapy. Physicians should pay considerable attention to @entity1 education regarding @entity715 . In addition, @entity1 should be supported in their ability to put on and take off the ECS independently. These rather simple interventions could improve compliance.

title: Eliciting @entity1 ' preferences for elastic compression stocking therapy after XXXX : potential for improving compliance.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['post-thrombotic syndrome', 'PTS']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis', 'DVT']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']


abstract: UNASSIGNED: Essentials Elastic compression stocking (ECS) therapy is used to prevent @entity715 ( @entity715 ). We aimed to elicit @entity1 preferences regarding ECS therapy after @entity1150 . The most valued attributes were @entity715 risk reduction and the ability to put on the ECS independently. Heterogeneous results with respect to education level stress the importance of proper counselling. SUMMARY: Background Elastic compression stocking (ECS) therapy is used for prevention of @entity715 ( @entity715 ) after @entity1150 ( @entity1150 ). Current evidence on its effectiveness is conflicting. Compliance, a major determinant of the effectiveness of ECS therapy, remained largely ignored in former studies. Objectives To gain insight into preferences regarding ECS therapy in @entity1 after @entity1150 . @entity1 /methods A discrete choice experiment was conducted 3 months after @entity1150 in @entity1 enrolled in the IDEAL @entity1150 study, a randomized controlled trial comparing 2 years of ECS therapy with individually tailored duration of ECS therapy for the prevention of @entity715 . Nine unlabeled, forced-choice sets of two hypothetical types of ECS were presented to each @entity1 . Data were analyzed with multinomial logit models. Results The respondent sample consisted of 81% (300/369) of invited @entity1 . The most important determinants of preference were @entity715 risk reduction and putting on the ECS. @entity1 were willing to increase the duration of therapy by 1 year if this increases the @entity715 risk reduction with 10%. @entity1 accepted an increase in the risk of @entity715 of 29% if they were able to put on the ECS themselves. Preferences were heterogeneous with respect to education level. Conclusions Reduction of the risk of @entity715 and the ability to put on the ECS without help are the most important characteristics of ECS therapy. Physicians should pay considerable attention to @entity1 education regarding @entity715 . In addition, @entity1 should be supported in their ability to put on and take off the ECS independently. These rather simple interventions could improve compliance.

title: Eliciting XXXX ' preferences for elastic compression stocking therapy after @entity1150 : potential for improving compliance.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Glandular @entity3 (GMs) (pancreas, breast, parotid, thyroid, or contralateral adrenal) are rare in metastatic @entity1358 (mccRCC). In a multicenter study we have assessed outcome from mccRCC with or without GMs. @entity1 AND METHODS: @entity1 with mccRCC and @entity7419 or non- @entity7419 (NGM) at first presentation of mccRCC, treated at 9 European centers (5 French, 3 UK, and 1 Belgian centers) between January 2004 and October 2013, were retrospectively analyzed. Association between overall survival (OS) and site of @entity3 was assessed using the log-rank test for univariate analysis and the chi-square test for multivariable Cox regression. RESULTS: In all, 138 @entity1 with @entity7419 mccRCC and 420 with NGM mccRCC were included; 37.2% @entity1 with @entity7419 had Memorial Sloan-Kettering Cancer Center (MSKCC)-favorable risk vs. 18% NGM @entity1 ; 10.7% @entity1 with @entity7419 had MSKCC-poor risk vs. 27% NGM @entity1 (P<0.0001). Median interval from @entity3 to treatment was 4.2 months (range: 0-221.3mo). Median OS was 61.5 months (51.4-81.6mo) for @entity7419 and 37.4 months (31.3-42mo) for NGM (hazard ratio [HR] = 1.7; 95% CI = 1.3-2.2, P<0.001). In univariate OS analysis, age, delay between initial diagnosis and @entity3 , MSKCC, bone/lung @entity3 , and @entity7419 or NGM group were significant parameters (P<0.001). In multivariate analysis, adjusted according to MSKCC risk group, NGM vs. @entity7419 was a strong prognostic factor (HR = 1.4; 95% CI = 1.0-1.8, P=0.026); bone or liver @entity3 were also significant (HR = 1.3; 95% CI = 1.1-1.7, P<0.02; HR = 1.4; 95% CI = 1.1-1.7, P<0.02, respectively). Even in @entity1 without bone or liver @entity3 , @entity7419 status was significant (HR = 1.8; 95% CI = 1.2-2.7, P<0.004). CONCLUSIONS: This large retrospective study shows that the presence of at least 1 @entity7419 site in development of mccRCC was associated with a significantly longer OS. The presence of GMs vs. NGM disease was an independent prognostic factor for survival irrespective of the presence or absence of bone or liver @entity3 . This finding could affect daily practice in which @entity1 with mccRCC and GMs should receive more aggressive treatment with a potential for long-term survival. The causal mechanisms for this improved prognosis in @entity7419 mccRCC would be evaluated in translational studies.

title: Effect of glandular @entity3 on overall survival of @entity1 with metastatic XXXX in the antiangiogenic therapy era.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['clear cell renal cell carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['clear cell renal cell carcinoma']


abstract: BACKGROUND: Glandular @entity3 (GMs) (pancreas, breast, parotid, thyroid, or contralateral adrenal) are rare in metastatic @entity1358 (mccRCC). In a multicenter study we have assessed outcome from mccRCC with or without GMs. @entity1 AND METHODS: @entity1 with mccRCC and @entity7419 or non- @entity7419 (NGM) at first presentation of mccRCC, treated at 9 European centers (5 French, 3 UK, and 1 Belgian centers) between January 2004 and October 2013, were retrospectively analyzed. Association between overall survival (OS) and site of @entity3 was assessed using the log-rank test for univariate analysis and the chi-square test for multivariable Cox regression. RESULTS: In all, 138 @entity1 with @entity7419 mccRCC and 420 with NGM mccRCC were included; 37.2% @entity1 with @entity7419 had Memorial Sloan-Kettering Cancer Center (MSKCC)-favorable risk vs. 18% NGM @entity1 ; 10.7% @entity1 with @entity7419 had MSKCC-poor risk vs. 27% NGM @entity1 (P<0.0001). Median interval from @entity3 to treatment was 4.2 months (range: 0-221.3mo). Median OS was 61.5 months (51.4-81.6mo) for @entity7419 and 37.4 months (31.3-42mo) for NGM (hazard ratio [HR] = 1.7; 95% CI = 1.3-2.2, P<0.001). In univariate OS analysis, age, delay between initial diagnosis and @entity3 , MSKCC, bone/lung @entity3 , and @entity7419 or NGM group were significant parameters (P<0.001). In multivariate analysis, adjusted according to MSKCC risk group, NGM vs. @entity7419 was a strong prognostic factor (HR = 1.4; 95% CI = 1.0-1.8, P=0.026); bone or liver @entity3 were also significant (HR = 1.3; 95% CI = 1.1-1.7, P<0.02; HR = 1.4; 95% CI = 1.1-1.7, P<0.02, respectively). Even in @entity1 without bone or liver @entity3 , @entity7419 status was significant (HR = 1.8; 95% CI = 1.2-2.7, P<0.004). CONCLUSIONS: This large retrospective study shows that the presence of at least 1 @entity7419 site in development of mccRCC was associated with a significantly longer OS. The presence of GMs vs. NGM disease was an independent prognostic factor for survival irrespective of the presence or absence of bone or liver @entity3 . This finding could affect daily practice in which @entity1 with mccRCC and GMs should receive more aggressive treatment with a potential for long-term survival. The causal mechanisms for this improved prognosis in @entity7419 mccRCC would be evaluated in translational studies.

title: Effect of glandular XXXX on overall survival of @entity1 with metastatic @entity1358 in the antiangiogenic therapy era.

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastases']


abstract: BACKGROUND: Glandular @entity3 (GMs) (pancreas, breast, parotid, thyroid, or contralateral adrenal) are rare in metastatic @entity1358 (mccRCC). In a multicenter study we have assessed outcome from mccRCC with or without GMs. @entity1 AND METHODS: @entity1 with mccRCC and @entity7419 or non- @entity7419 (NGM) at first presentation of mccRCC, treated at 9 European centers (5 French, 3 UK, and 1 Belgian centers) between January 2004 and October 2013, were retrospectively analyzed. Association between overall survival (OS) and site of @entity3 was assessed using the log-rank test for univariate analysis and the chi-square test for multivariable Cox regression. RESULTS: In all, 138 @entity1 with @entity7419 mccRCC and 420 with NGM mccRCC were included; 37.2% @entity1 with @entity7419 had Memorial Sloan-Kettering Cancer Center (MSKCC)-favorable risk vs. 18% NGM @entity1 ; 10.7% @entity1 with @entity7419 had MSKCC-poor risk vs. 27% NGM @entity1 (P<0.0001). Median interval from @entity3 to treatment was 4.2 months (range: 0-221.3mo). Median OS was 61.5 months (51.4-81.6mo) for @entity7419 and 37.4 months (31.3-42mo) for NGM (hazard ratio [HR] = 1.7; 95% CI = 1.3-2.2, P<0.001). In univariate OS analysis, age, delay between initial diagnosis and @entity3 , MSKCC, bone/lung @entity3 , and @entity7419 or NGM group were significant parameters (P<0.001). In multivariate analysis, adjusted according to MSKCC risk group, NGM vs. @entity7419 was a strong prognostic factor (HR = 1.4; 95% CI = 1.0-1.8, P=0.026); bone or liver @entity3 were also significant (HR = 1.3; 95% CI = 1.1-1.7, P<0.02; HR = 1.4; 95% CI = 1.1-1.7, P<0.02, respectively). Even in @entity1 without bone or liver @entity3 , @entity7419 status was significant (HR = 1.8; 95% CI = 1.2-2.7, P<0.004). CONCLUSIONS: This large retrospective study shows that the presence of at least 1 @entity7419 site in development of mccRCC was associated with a significantly longer OS. The presence of GMs vs. NGM disease was an independent prognostic factor for survival irrespective of the presence or absence of bone or liver @entity3 . This finding could affect daily practice in which @entity1 with mccRCC and GMs should receive more aggressive treatment with a potential for long-term survival. The causal mechanisms for this improved prognosis in @entity7419 mccRCC would be evaluated in translational studies.

title: Effect of glandular @entity3 on overall survival of XXXX with metastatic @entity1358 in the antiangiogenic therapy era.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: To establish a series of objective parameters to predict the risk of relapse from axillary lymph node-negative (ANN) @entity0 , and evaluate the patterns of recurrence according to molecular subtypes, we collected information on 2126 consecutive @entity0 @entity1 operated between 2002 and 2006. In this case-control study, 212 @entity1 experiencing recurrence or @entity0 related @entity204 were defined as 'poor group'. Another 212 @entity1 were selected from the remaining cases with stratified sampling method to comprise the 'good group'. Significant differences were found in vascular invasion, grade and molecular subtype between the two groups. Expression of ER and PR in the 'poor group' was lower (P < 0.05). However, positive rates of Ki67, @entity876 and @entity7 in the 'poor group' were higher (P < 0.05). Multivariate analysis revealed that molecular subtype, expression of @entity7 , @entity5 grade, and vascular invasion were closely correlated with bad outcome. Analysis of the 'poor group' demonstrated that ' @entity1722 positive' and 'triple negative' subtypes more commonly suffered from distant metastases and @entity204 . No @entity3 was found in @entity1 with pure invasive @entity1377 , invasive @entity420 or @entity2347 , whereas the diagnoses of invasive @entity189 , invasive @entity189 , invasive @entity1377 mixed @entity513 , or @entity189 were correlated with distant @entity3 and @entity204 . In conclusion, molecular subtype and expression of @entity7 are useful markers for predicting prognosis of ANN @entity0 @entity1 . 'Luminal A-like' subtype has better outcome than others. Moreover, molecular subtypes have different recurrence patterns.

title: Predictors of recurrence in XXXX subtypes with negative lymph node in a Chinese population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinoma']

entities_list: @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['micropapillary carcinoma', 'apocrine carcinoma', 'metaplastic carcinoma']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['with invasive ductal carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['cribriform carcinoma']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: @entity9 is generally defined as a @entity1118 state resulting from peripheral and/or central @entity128 . There is a lack of effective treatment for @entity9 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity6108 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity1118 induced by peripheral administration of inflammatory agents such as @entity406 . In this study, we aimed to show the effect of @entity6108 on @entity158 behavior and serum @entity4665 level in a @entity8638 ( @entity8638 ) model of @entity9 . METHODS: @entity35 male @entity35 (150-200 g, n = 8) were divided into three groups: @entity8638 vehicle-treated, sham-operated, and @entity8638 drug-treated group. @entity6108 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity4665 level was measured on day 7 after the surgery. RESULTS: @entity6108 (50 mg/kg) decreased mechanical and cold @entity1931 (P < 0.001) and produced a decline in serum @entity4665 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity158 behavior and serum @entity4665 levels was seen in @entity35 following administration of @entity6108 in @entity8638 model of @entity9 . High concentration of @entity6108 was able to reduce the chronic @entity9 induced by @entity8638 model and the serum level of @entity4665 .

title: The Attenuation of Pain Behavior and Serum @entity4665 Concentration by @entity6108 in a @entity35 Model of XXXX .

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury']

entities_list: @entity6108 :: ('MESH:D003474', 'Chemical') :: ['Curcumin', 'curcumin']

entities_list: @entity8638 :: ('MESH:D020208', 'Disease') :: ['Chronic Constriction Injury', 'CCI']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'Neuropathic pain']

answer: @entity9 :: (MESH:D009437,Disease) :: ['Neuropathic Pain']


abstract: BACKGROUND: @entity9 is generally defined as a @entity1118 state resulting from peripheral and/or central @entity128 . There is a lack of effective treatment for @entity9 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity6108 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity1118 induced by peripheral administration of inflammatory agents such as @entity406 . In this study, we aimed to show the effect of @entity6108 on @entity158 behavior and serum @entity4665 level in a @entity8638 ( @entity8638 ) model of @entity9 . METHODS: @entity35 male @entity35 (150-200 g, n = 8) were divided into three groups: @entity8638 vehicle-treated, sham-operated, and @entity8638 drug-treated group. @entity6108 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity4665 level was measured on day 7 after the surgery. RESULTS: @entity6108 (50 mg/kg) decreased mechanical and cold @entity1931 (P < 0.001) and produced a decline in serum @entity4665 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity158 behavior and serum @entity4665 levels was seen in @entity35 following administration of @entity6108 in @entity8638 model of @entity9 . High concentration of @entity6108 was able to reduce the chronic @entity9 induced by @entity8638 model and the serum level of @entity4665 .

title: The Attenuation of Pain Behavior and Serum XXXX Concentration by @entity6108 in a @entity35 Model of @entity9 .

answer: @entity4665 :: (26198(Tax:10116),Gene) :: ['COX-2']


abstract: BACKGROUND: @entity9 is generally defined as a @entity1118 state resulting from peripheral and/or central @entity128 . There is a lack of effective treatment for @entity9 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity6108 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity1118 induced by peripheral administration of inflammatory agents such as @entity406 . In this study, we aimed to show the effect of @entity6108 on @entity158 behavior and serum @entity4665 level in a @entity8638 ( @entity8638 ) model of @entity9 . METHODS: @entity35 male @entity35 (150-200 g, n = 8) were divided into three groups: @entity8638 vehicle-treated, sham-operated, and @entity8638 drug-treated group. @entity6108 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity4665 level was measured on day 7 after the surgery. RESULTS: @entity6108 (50 mg/kg) decreased mechanical and cold @entity1931 (P < 0.001) and produced a decline in serum @entity4665 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity158 behavior and serum @entity4665 levels was seen in @entity35 following administration of @entity6108 in @entity8638 model of @entity9 . High concentration of @entity6108 was able to reduce the chronic @entity9 induced by @entity8638 model and the serum level of @entity4665 .

title: The Attenuation of Pain Behavior and Serum @entity4665 Concentration by XXXX in a @entity35 Model of @entity9 .

answer: @entity6108 :: (MESH:D003474,Chemical) :: ['Curcumin']


abstract: BACKGROUND: @entity9 is generally defined as a @entity1118 state resulting from peripheral and/or central @entity128 . There is a lack of effective treatment for @entity9 , which may possibly be related to poor understanding of pathological mechanisms at the molecular level. @entity6108 , a therapeutic herbal extract, has shown to be effectively capable of reducing @entity1118 induced by peripheral administration of inflammatory agents such as @entity406 . In this study, we aimed to show the effect of @entity6108 on @entity158 behavior and serum @entity4665 level in a @entity8638 ( @entity8638 ) model of @entity9 . METHODS: @entity35 male @entity35 (150-200 g, n = 8) were divided into three groups: @entity8638 vehicle-treated, sham-operated, and @entity8638 drug-treated group. @entity6108 (12.5, 25, 50 mg/kg, IP) was injected 24 h before surgery and continued daily for 7 days post-surgery. Behavioral tests were performed once before and following the days 1, 3, 5, 7 after surgery. The serum @entity4665 level was measured on day 7 after the surgery. RESULTS: @entity6108 (50 mg/kg) decreased mechanical and cold @entity1931 (P < 0.001) and produced a decline in serum @entity4665 level (P < 0.001). CONCLUSIONS: A considerable decline in @entity158 behavior and serum @entity4665 levels was seen in @entity35 following administration of @entity6108 in @entity8638 model of @entity9 . High concentration of @entity6108 was able to reduce the chronic @entity9 induced by @entity8638 model and the serum level of @entity4665 .

title: The Attenuation of Pain Behavior and Serum @entity4665 Concentration by @entity6108 in a XXXX Model of @entity9 .

answer: @entity35 :: (10116,Species) :: ['Rat']


abstract: PURPOSE: It is known that antiepileptic drugs might adversely affect neuronal function and thus influence brain development. However, we have reported that @entity4218 are one of the most prominent disturbances caused by @entity4481 ( @entity11974 ) in the developing embryo. The aim of this work is to gain a better understanding of possible molecular mechanisms behind the @entity85 and @entity4218 associated with @entity11974 . METHODS: Pregnant @entity19 divided into four groups. Each @entity19 received an intraperitoneal injection (IP) of 0, 20 (group I), 40 (group II) or 80 (group III) mg/kg/day of @entity11974 during the organogenesis period. On gestational day 18, embryos were separated and their limbs were dissected. Levels of apoptotic proteins were analyzed by Western blotting. To establish whether apoptosis is present in the limbs, the specimens were examined by TUNEL. Pathological findings were also reported as a score ranging from 1 to 3 based on the level of differentiation. RESULTS: Western blot analysis demonstrated that @entity11974 in all @entity11974 -treated groups significantly upregulated the levels of cleaved caspase-3, 8 and 9. Also, the results showed that @entity11974 exposure increased the percentage of TUNEL positive cells in different limb tissues especially the mesenchymal tissue. The histopathological findings revealed that @entity11974 administration to pregnant @entity19 inhibited limb tissue differentiation, albeit to varying degrees. CONCLUSIONS: The result of our study revealed that apoptosis and inhibition of limb tissue differentiation play an important role in the pathogenesis of @entity11974 -induced @entity4218 . Both intrinsic and extrinsic caspase-dependent pathways of cell death are important in mediating the abnormal limb development triggered by insult with the @entity11974 . Evaluating the effect of @entity11974 on molecules involved in the cross-talk between intrinsic and extrinsic apoptotic pathways and cell adhesion, migration, proliferation, and differentiation during embryonic development can further help to identify and clarify the involved mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

title: Pathogenesis of XXXX -Induced @entity4218 in @entity19 Embryos.

entities_list: @entity4218 :: ('MESH:D017880', 'Disease') :: ['limb deformities', 'limb malformations']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal injuries']

entities_list: @entity4481 :: ('MESH:C080245', 'Chemical') :: ['pregabalin']

answer: @entity4481 :: (MESH:C080245,Chemical) :: ['Pregabalin']


abstract: PURPOSE: It is known that antiepileptic drugs might adversely affect neuronal function and thus influence brain development. However, we have reported that @entity4218 are one of the most prominent disturbances caused by @entity4481 ( @entity11974 ) in the developing embryo. The aim of this work is to gain a better understanding of possible molecular mechanisms behind the @entity85 and @entity4218 associated with @entity11974 . METHODS: Pregnant @entity19 divided into four groups. Each @entity19 received an intraperitoneal injection (IP) of 0, 20 (group I), 40 (group II) or 80 (group III) mg/kg/day of @entity11974 during the organogenesis period. On gestational day 18, embryos were separated and their limbs were dissected. Levels of apoptotic proteins were analyzed by Western blotting. To establish whether apoptosis is present in the limbs, the specimens were examined by TUNEL. Pathological findings were also reported as a score ranging from 1 to 3 based on the level of differentiation. RESULTS: Western blot analysis demonstrated that @entity11974 in all @entity11974 -treated groups significantly upregulated the levels of cleaved caspase-3, 8 and 9. Also, the results showed that @entity11974 exposure increased the percentage of TUNEL positive cells in different limb tissues especially the mesenchymal tissue. The histopathological findings revealed that @entity11974 administration to pregnant @entity19 inhibited limb tissue differentiation, albeit to varying degrees. CONCLUSIONS: The result of our study revealed that apoptosis and inhibition of limb tissue differentiation play an important role in the pathogenesis of @entity11974 -induced @entity4218 . Both intrinsic and extrinsic caspase-dependent pathways of cell death are important in mediating the abnormal limb development triggered by insult with the @entity11974 . Evaluating the effect of @entity11974 on molecules involved in the cross-talk between intrinsic and extrinsic apoptotic pathways and cell adhesion, migration, proliferation, and differentiation during embryonic development can further help to identify and clarify the involved mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

title: Pathogenesis of @entity4481 -Induced XXXX in @entity19 Embryos.

answer: @entity4218 :: (MESH:D017880,Disease) :: ['Limb Defects']


abstract: PURPOSE: It is known that antiepileptic drugs might adversely affect neuronal function and thus influence brain development. However, we have reported that @entity4218 are one of the most prominent disturbances caused by @entity4481 ( @entity11974 ) in the developing embryo. The aim of this work is to gain a better understanding of possible molecular mechanisms behind the @entity85 and @entity4218 associated with @entity11974 . METHODS: Pregnant @entity19 divided into four groups. Each @entity19 received an intraperitoneal injection (IP) of 0, 20 (group I), 40 (group II) or 80 (group III) mg/kg/day of @entity11974 during the organogenesis period. On gestational day 18, embryos were separated and their limbs were dissected. Levels of apoptotic proteins were analyzed by Western blotting. To establish whether apoptosis is present in the limbs, the specimens were examined by TUNEL. Pathological findings were also reported as a score ranging from 1 to 3 based on the level of differentiation. RESULTS: Western blot analysis demonstrated that @entity11974 in all @entity11974 -treated groups significantly upregulated the levels of cleaved caspase-3, 8 and 9. Also, the results showed that @entity11974 exposure increased the percentage of TUNEL positive cells in different limb tissues especially the mesenchymal tissue. The histopathological findings revealed that @entity11974 administration to pregnant @entity19 inhibited limb tissue differentiation, albeit to varying degrees. CONCLUSIONS: The result of our study revealed that apoptosis and inhibition of limb tissue differentiation play an important role in the pathogenesis of @entity11974 -induced @entity4218 . Both intrinsic and extrinsic caspase-dependent pathways of cell death are important in mediating the abnormal limb development triggered by insult with the @entity11974 . Evaluating the effect of @entity11974 on molecules involved in the cross-talk between intrinsic and extrinsic apoptotic pathways and cell adhesion, migration, proliferation, and differentiation during embryonic development can further help to identify and clarify the involved mechanisms.This article is open to POST-PUBLICATION REVIEW. Registered readers (see "For Readers") may comment by clicking on ABSTRACT on the issue's contents page.

title: Pathogenesis of @entity4481 -Induced @entity4218 in XXXX Embryos.

answer: @entity19 :: (10090,Species) :: ['Mouse']


abstract: UNASSIGNED: Based on the recently proposed Chinese @entity385 (CISS) system, intracranial branch @entity66 (BAD) is divided into large artery @entity731 (LAA) and @entity455 ( @entity455 ). In the current retrospective analysis, we compared the general characteristics of BAD-LAA with BAD- @entity455 , BAD-LAA with non-BAD-LAA and BAD- @entity455 with non-BAD- @entity455 . The study included a total of 80 cases, including 45 cases of BAD and 35 cases of non-BAD. Subjects were classified using CISS system: BAD-LAA, BAD- @entity455 , non-BAD-LAA and non-BAD- @entity455 . In addition to analysis of general characteristics, the correlation between the factors and the two subtypes of BAD was evaluated. The number of cases included in the analysis was: 32 cases of BAD-LAA, 13 cases of BAD- @entity455 , 21 cases of non-BAD-LAA, and 14 cases of non-BAD- @entity455 . @entity6 affected more non-BAD-LAA @entity1 than BAD-LAA @entity1 (P=0.035). In comparison with non-BAD- @entity455 , @entity1 with BAD- @entity455 were younger (P=0.040), had higher initial NIHSS score (P<0.001) and morbidity of @entity741 (P=0.033). Within @entity1 with BAD, the @entity455 subtype was associated with smoking (OR=0.043; P=0.011), higher low-density lipoprotein (OR=5.339; P=0.029), @entity741 (OR=9.383; P=0.047) and @entity6 (OR=12.59; P=0.020). It was concluded that large artery @entity731 was the primary mechanism of BAD. The general characteristics showed no significant differences between the CISS subtypes of LAA and @entity455 within BAD, as well as between the BAD and non-BAD within LAA subtype. Several differences between @entity455 subtypes of BAD and non-BAD were revealed.

title: Comparative analysis of general characteristics of XXXX of BAD and non-BAD CISS subtypes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['penetrating artery disease', 'PAD']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['atheromatous disease']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes mellitus', 'diabetes mellitus']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke subclassification']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: Purpose. We present a case with @entity4917 that had unilateral mature @entity231 and @entity1715 . Case Report. A 17-year-old @entity1 with @entity4917 presented to the clinic of ophthalmology for @entity4064 in the right eye. His best corrected visual acuity (BCVA) was hand motion in the right eye and 20/20 in the left eye. Anterior segment examination revealed mature @entity231 in the right. During the physical examination, @entity3809 were noted over right side of his face, ankle, and toes. He had asymmetric face and his head was larger on the right side. Leg lengths were symmetrical, although he had @entity272 . Cranial magnetic resonance imaging studies showed @entity194 discordant to his age, asymmetric vascular dilatations in the right hemisphere, @entity1184 in the right periorbital soft tissue, and choroidal plexus. The @entity1 received an uncomplicated @entity231 surgery. His BCVA in the right eye improved to 20/200 after the surgery. After removing cataractous lens, we were able to examine the fundus that revealed severe @entity1715 and @entity3193 . Conclusion. This case emphasizes the importance of prompt ophthalmic examination in @entity1 with @entity4917 .

title: @entity231 and XXXX in a case with @entity4917 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'boy']

entities_list: @entity1715 :: ('MESH:D018630', 'Disease') :: ['vitreoretinopathy']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity3809 :: ('MESH:D019339', 'Disease') :: ['port-wine stains']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin hypertrophy']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['cortical atrophy']

entities_list: @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal hemangioma']

entities_list: @entity4917 :: ('MESH:D007715', 'Disease') :: ['KT syndrome', 'Klippel-Trenaunay (KT) syndrome']

entities_list: @entity4064 :: ('MESH:D015354', 'Disease') :: ['low vision']

answer: @entity1715 :: (MESH:D018630,Disease) :: ['vitreoretinopathy']


abstract: Purpose. We present a case with @entity4917 that had unilateral mature @entity231 and @entity1715 . Case Report. A 17-year-old @entity1 with @entity4917 presented to the clinic of ophthalmology for @entity4064 in the right eye. His best corrected visual acuity (BCVA) was hand motion in the right eye and 20/20 in the left eye. Anterior segment examination revealed mature @entity231 in the right. During the physical examination, @entity3809 were noted over right side of his face, ankle, and toes. He had asymmetric face and his head was larger on the right side. Leg lengths were symmetrical, although he had @entity272 . Cranial magnetic resonance imaging studies showed @entity194 discordant to his age, asymmetric vascular dilatations in the right hemisphere, @entity1184 in the right periorbital soft tissue, and choroidal plexus. The @entity1 received an uncomplicated @entity231 surgery. His BCVA in the right eye improved to 20/200 after the surgery. After removing cataractous lens, we were able to examine the fundus that revealed severe @entity1715 and @entity3193 . Conclusion. This case emphasizes the importance of prompt ophthalmic examination in @entity1 with @entity4917 .

title: XXXX and @entity1715 in a case with @entity4917 .

answer: @entity231 :: (MESH:D002386,Disease) :: ['Unilateral cataract']


abstract: Purpose. We present a case with @entity4917 that had unilateral mature @entity231 and @entity1715 . Case Report. A 17-year-old @entity1 with @entity4917 presented to the clinic of ophthalmology for @entity4064 in the right eye. His best corrected visual acuity (BCVA) was hand motion in the right eye and 20/20 in the left eye. Anterior segment examination revealed mature @entity231 in the right. During the physical examination, @entity3809 were noted over right side of his face, ankle, and toes. He had asymmetric face and his head was larger on the right side. Leg lengths were symmetrical, although he had @entity272 . Cranial magnetic resonance imaging studies showed @entity194 discordant to his age, asymmetric vascular dilatations in the right hemisphere, @entity1184 in the right periorbital soft tissue, and choroidal plexus. The @entity1 received an uncomplicated @entity231 surgery. His BCVA in the right eye improved to 20/200 after the surgery. After removing cataractous lens, we were able to examine the fundus that revealed severe @entity1715 and @entity3193 . Conclusion. This case emphasizes the importance of prompt ophthalmic examination in @entity1 with @entity4917 .

title: @entity231 and @entity1715 in a case with XXXX .

answer: @entity4917 :: (MESH:D007715,Disease) :: ['klippel-trenaunay syndrome']


abstract: UNASSIGNED: @entity957 ( @entity957 ) is a rare @entity5 for which there are limited treatment options due to a poor understanding of the molecular alterations underlying disease development and progression. Therefore, we performed comprehensive, targeted next-generation sequencing to identify relevant somatic genomic alterations in a retrospective cohort of 60 fixed @entity5 samples from 43 @entity957 cases (including 14 matched primary/ @entity3 pairs). We identified a median of two relevant somatic mutations and one high-level copy-number alteration per sample (range, 0-5 and 0-6, respectively). Expression of HPV and @entity986 was detectable in 12% and 28% of @entity1 , respectively. Furthermore, advanced clinical stage, lack of @entity986 expression, and MYC and @entity4910 amplifications were significantly associated with shorter time to progression or @entity957 -specific survival. Notably, four cases harbored @entity470 amplifications and one demonstrated @entity8985 amplification, genes for which approved and investigational targeted therapies are available. Importantly, although paired @entity5 and lymph node @entity3 were largely homogeneous for relevant somatic mutations, we identified heterogeneous @entity470 amplification in primary @entity5 /lymph node @entity3 in 4 of 14 cases, despite uniform @entity470 protein overexpression. Likewise, activating @entity8498 mutations occurred in 8 of 43 cases. Taken together, we provide the first comprehensive molecular @entity957 analysis, which offers new insight into potential precision medicine approaches for this disease, including strategies targeting @entity470 . @entity5 Res; 75(24); 5219-27.   2015 AACR.

title: Genomic Profiling of XXXX Reveals New Opportunities for Targeted Therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'malignancy', 'Cancer']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['Penile squamous cell carcinoma', 'PeSCCA']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

answer: @entity957 :: (MESH:D002294,Disease) :: ['Penile Squamous Cell Carcinoma']


abstract: A pregnant @entity1 presented with acute upper @entity490 and @entity390 at 15 weeks' gestation. She had a history of cesarean delivery for abruption after the removal of a Shirodkar cerclage that was placed because of cervical @entity3207 caused by conization. She became pregnant again 14 months later. Ultrasonography revealed no significant findings, and a single intrauterine pregnancy with positive fetal heart activity was confirmed. An @entity1321 was suspected because abdominal radiography showed multiple air-fluid levels in the colon. Over the 3 hours following admission, her symptoms gradually worsened, and plain abdominal computed tomography (CT) showed a large @entity548 in the abdominal cavity, but the uterine wall appeared intact at this time. Subsequently, dynamic CT revealed discontinuity of the uterine muscle layer. During laparotomy, uterine @entity397 with complete opening of the uterine wall at the site of the previous transverse scar was identified. A dead fetus was located within the amniotic sac in a blood-filled abdominal cavity. She received a total of 10 units of packed red blood cells and 6 units of fresh frozen plasma for the resuscitation. She was discharged on the eighth postoperative day without any complications.

title: Spontaneous uterine XXXX at 15 weeks' gestation in a @entity1 with a history of cesarean delivery after removal of shirodkar cerclage.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity3207 :: ('MESH:C535850', 'Disease') :: ['shortening']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

answer: @entity397 :: (MESH:D012421,Disease) :: ['rupture']


abstract: A pregnant @entity1 presented with acute upper @entity490 and @entity390 at 15 weeks' gestation. She had a history of cesarean delivery for abruption after the removal of a Shirodkar cerclage that was placed because of cervical @entity3207 caused by conization. She became pregnant again 14 months later. Ultrasonography revealed no significant findings, and a single intrauterine pregnancy with positive fetal heart activity was confirmed. An @entity1321 was suspected because abdominal radiography showed multiple air-fluid levels in the colon. Over the 3 hours following admission, her symptoms gradually worsened, and plain abdominal computed tomography (CT) showed a large @entity548 in the abdominal cavity, but the uterine wall appeared intact at this time. Subsequently, dynamic CT revealed discontinuity of the uterine muscle layer. During laparotomy, uterine @entity397 with complete opening of the uterine wall at the site of the previous transverse scar was identified. A dead fetus was located within the amniotic sac in a blood-filled abdominal cavity. She received a total of 10 units of packed red blood cells and 6 units of fresh frozen plasma for the resuscitation. She was discharged on the eighth postoperative day without any complications.

title: Spontaneous uterine @entity397 at 15 weeks' gestation in a XXXX with a history of cesarean delivery after removal of shirodkar cerclage.

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity2167 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity1 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity1 had been diagnosed with either @entity2395 major (BTM) or @entity2395 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity68 chelator-either @entity27101 , @entity5532 ( @entity5532 in the United States), @entity23224 , or a combination of @entity5532 and @entity23224 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity1 . In the right ears, the overall incidence of @entity2167 as manifested by @entity1274 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity2167 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity2167 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity1 with suspected @entity2395 in order arrive at a prompt diagnosis and initiate timely management.

title: XXXX in @entity2395 @entity1 treated with @entity68 chelation.

entities_list: @entity5532 :: ('MESH:D003676', 'Chemical') :: ['deferoxamine', 'desferrioxamine']

entities_list: @entity2167 :: ('MESH:D006311', 'Disease') :: ['ototoxicity']

entities_list: @entity23224 :: ('MESH:C044919', 'Chemical') :: ['deferiprone']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss']

entities_list: @entity27101 :: ('MESH:C415250', 'Chemical') :: ['deferasirox']

entities_list: @entity2395 :: ('MESH:D013789', 'Disease') :: ['b-thalassemia']

answer: @entity1274 :: (MESH:D006319,Disease) :: ['Sensorineural hearing loss']


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity2167 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity1 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity1 had been diagnosed with either @entity2395 major (BTM) or @entity2395 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity68 chelator-either @entity27101 , @entity5532 ( @entity5532 in the United States), @entity23224 , or a combination of @entity5532 and @entity23224 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity1 . In the right ears, the overall incidence of @entity2167 as manifested by @entity1274 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity2167 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity2167 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity1 with suspected @entity2395 in order arrive at a prompt diagnosis and initiate timely management.

title: @entity1274 in XXXX @entity1 treated with @entity68 chelation.

answer: @entity2395 :: (MESH:D013789,Disease) :: ['b-thalassemia']


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity2167 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity1 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity1 had been diagnosed with either @entity2395 major (BTM) or @entity2395 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity68 chelator-either @entity27101 , @entity5532 ( @entity5532 in the United States), @entity23224 , or a combination of @entity5532 and @entity23224 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity1 . In the right ears, the overall incidence of @entity2167 as manifested by @entity1274 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity2167 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity2167 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity1 with suspected @entity2395 in order arrive at a prompt diagnosis and initiate timely management.

title: @entity1274 in @entity2395 @entity1 treated with XXXX chelation.

answer: @entity68 :: (MESH:D007501,Chemical) :: ['iron']


abstract: UNASSIGNED: The predictive value of pure-tone audiometry (PTA) in the early detection of @entity2167 has been questioned, particularly in the higher frequencies. Otoacoustic emissions testing appears to be more sensitive to cochlear insult than conventional PTA. We conducted a cross-sectional descriptive study to compare the efficacy of distortion-product otoacoustic emissions (DPOAE) testing with that of PTA as a method of audiologic monitoring. Our study group was made up of 159 @entity1 (318 ears)-69 males (43.4%) and 90 females (56.6%), aged 5 to 61 years (mean: 23.59    12.55). All @entity1 had been diagnosed with either @entity2395 major (BTM) or @entity2395 intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an @entity68 chelator-either @entity27101 , @entity5532 ( @entity5532 in the United States), @entity23224 , or a combination of @entity5532 and @entity23224 . PTA and DPOAE evaluations were performed by the same audiologist using the same audiometer for all @entity1 . In the right ears, the overall incidence of @entity2167 as manifested by @entity1274 was 39.0% on PTA and 22.0% on DPOAE testing; in the left ears, the corresponding figures were 27.7 and 19.5%, respectively. There were no statistically significant differences in the incidence of @entity2167 between the BTM and BTI groups with any of the four different drug regimens on PTA (p = 0.765, p = 0.378, p = 0.265, and p = 0.579, respectively) or on DPOAE testing (p = 0.890, p = 0.263, p = 0.390, and p = 0.340, respectively). Based on these data, we found no significant difference between PTA and DPOAE testing in their ability to detect @entity2167 . We conclude that periodic testing with both PTA and DPOAE is necessary for @entity1 with suspected @entity2395 in order arrive at a prompt diagnosis and initiate timely management.

title: @entity1274 in @entity2395 XXXX treated with @entity68 chelation.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION: @entity2828 ( @entity2828 ) is the second most common @entity3478 in @entity1 . Current chemotherapeutic regimens include high-dose @entity8253 and alkylating agents with significant variation in treatment length. The Memorial Sloan Kettering Cancer Center P6 regimen (MSKCC P6) treatment protocol is a highly aggressive regimen given over 21 weeks only. We present the outcome of @entity2828 @entity1 treated in our center with this protocol over the last 15 years. PROCEDURE: We retrospectively analyzed data on the presentation, @entity1 characteristics, treatment, and outcome of all @entity2828 @entity1 treated according to the MSKCC P6 regimen from 1999 to 2014. RESULTS: Of 48 @entity1 , 37 (77%) presented with a nonmetastatic disease and 26 (54%) with @entity5 located in the extremities. The 5-year overall survival (OS) of the entire cohort was 55.9%  8%. @entity66 conferred a better prognosis with a 5-year OS of 68.4%  8.5%. @entity1 with a nonmetastatic extremity @entity5 had the most favorable outcome with 5-year OS of 72.2%  9.8%. CONCLUSION: The outcome of @entity2828 @entity1 after a short aggressive course of chemotherapy (the MSKCC P6 protocol), is comparable to that following other first-line treatment regimens in use, with potentially fewer long-term adverse events.

title: XXXX : A 15-Year Experience of a Single Center With the MSKCC P6 Treatment Protocol.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient']

entities_list: @entity2828 :: ('MESH:D012512', 'Disease') :: ['ES', 'Ewing sarcoma']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Nonmetastatic disease']

entities_list: @entity8253 :: ('MESH:D018943', 'Chemical') :: ['anthracyclines']

entities_list: @entity3478 :: ('MESH:D001859', 'Disease') :: ['bone tumor']

answer: @entity2828 :: (MESH:D012512,Disease) :: ['Ewing Sarcoma']