abstract: UNASSIGNED: Currently, few techniques are available for the evaluation of bacterial biofilm adhesion. These detection tools generally require time for culture and/or arduous handling steps.In this work, the Biofilm Ring Test   (BRT), a new technology, was used to estimate the biofilm formation kinetics of twenty-five strains of @entity796 , isolated from sputum of @entity1577 ( @entity1577 ) @entity1 . The new assay principle is based on the mobility measurement of magnetic microbeads mixed with a bacterial suspension in a @entity852 microplate. If free to move under the magnet action, particles gather to a visible central spot in the well bottom. Therefore, the absence of spot formation in the plate reflects the bead immobilisation by a biofilm in formation.The BRT device allowed us to classify the bacterial strains in three general adhesion profiles. The group 1 consists in bacteria, which are able to form a solid biofilm in less than two hours. The group 2 comprises the strains, which progressively set up a biofilm during 24h. Lastly, the group 3 includes the strains, which stay in a planktonic form. The belonging of our strains to these profiles didn't differ according to culture conditions as the use of different sets of beads or culture media.The BRT is shown to be an informative tool for the characterization of biofilm-forming bacteria. Various application perspectives could be investigated for that device, such as the addition of antibiotics to the bacterial suspension to select the ones, which would have the ability to inhibit the biofilm formation.

title: The Biofilm Ring Test  : a rapid method for the routine analysis of XXXX biofilm formation kinetics.

entities_list: @entity852 :: ('MESH:D011137', 'Chemical') :: ['polystyrene']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa']

entities_list: @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'cystic fibrosis']

answer: @entity796 :: (287,Species) :: ['P. aeruginosa']


abstract: @entity124 ( @entity124 ) and @entity2007 are inversely related phenomena. We tested whether ploidy status influences the clinical impact of @entity124 in @entity1204 ( @entity1204 ). We analyzed 167 EECs for @entity124 and ploidy. @entity5 were classified in three categories according to @entity124 and ploidy status. Associations with clinicopathological and molecular variables, survival, and treatment response were assessed. All @entity5 (23%) were scored as diploid, and 14% of microsatellite stable (MSS) @entity5 presented @entity2007 . @entity5 associated with older age at diagnosis, @entity28 , high histological grade, and advanced surgical stage. @entity5 also associated with higher grade and advanced stage. In multivariate survival analysis @entity124 did not influence disease-free survival (DFS) or @entity5 -specific survival (CSS). However, when just @entity5 were considered for the analysis, @entity124 significantly contributed to worse DFS and CSS, and the same was observed for @entity2007 when @entity5 were analyzed alone. In @entity5 , a differential response to postoperative radiotherapy (RT) was observed according to @entity124 , since it predicted poor DFS and CSS in the multivariate analysis. We conclude that ploidy status influences the clinical impact of @entity124 in @entity1204 . Among @entity5 those with @entity124 have poor clinical outcome and respond worse to RT.

title: XXXX and ploidy status define three categories with distinctive prognostic impact in @entity1204 .

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrioid endometrial cancer', 'EEC']

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy']

entities_list: @entity124 :: ('MESH:D053842', 'Disease') :: ['Microsatellite instability', 'MSI']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['non-obesity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors', 'MSS tumors', 'MSI tumors', 'cancer', 'MSS-aneuploid tumors', 'diploid tumors', 'tumors']

answer: @entity124 :: (MESH:D053842,Disease) :: ['Microsatellite instability']


abstract: @entity124 ( @entity124 ) and @entity2007 are inversely related phenomena. We tested whether ploidy status influences the clinical impact of @entity124 in @entity1204 ( @entity1204 ). We analyzed 167 EECs for @entity124 and ploidy. @entity5 were classified in three categories according to @entity124 and ploidy status. Associations with clinicopathological and molecular variables, survival, and treatment response were assessed. All @entity5 (23%) were scored as diploid, and 14% of microsatellite stable (MSS) @entity5 presented @entity2007 . @entity5 associated with older age at diagnosis, @entity28 , high histological grade, and advanced surgical stage. @entity5 also associated with higher grade and advanced stage. In multivariate survival analysis @entity124 did not influence disease-free survival (DFS) or @entity5 -specific survival (CSS). However, when just @entity5 were considered for the analysis, @entity124 significantly contributed to worse DFS and CSS, and the same was observed for @entity2007 when @entity5 were analyzed alone. In @entity5 , a differential response to postoperative radiotherapy (RT) was observed according to @entity124 , since it predicted poor DFS and CSS in the multivariate analysis. We conclude that ploidy status influences the clinical impact of @entity124 in @entity1204 . Among @entity5 those with @entity124 have poor clinical outcome and respond worse to RT.

title: @entity124 and ploidy status define three categories with distinctive prognostic impact in XXXX .

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrioid endometrial cancer']


abstract: CONTEXT: Scilla scilloides Druce (Liliaceae) is a folk medicine to treat dermal @entity32 ; however, the medicinal properties of this plant have not been completely established. OBJECTIVE: The current study investigates the potent anti-inflammatory effects of S. scilloides bulbs for its traditional usage using lipoxygenase and hyaluronidase as the @entity32 model. To gain insight into the active constituents, nine homoisoflavones (1-9) were subsequently tested. MATERIALS AND METHODS: Lipoxygenase and hyaluronidase inhibition of @entity1046 extract from the bulbs of this plant within 2000     g/mL or homoisoflavones within 1000     M were determined by colorimetric methods. RAW264.7 cells were incubated with 10 or 50     M @entity6400 plus lipopolysaccharide (LPS) for 24   h. The culture media were collected and analyzed for determination of the @entity842 (NO) level by the colorimetric Griess method to measure the extent of @entity32 . RESULTS: The extract exhibited inhibitory effects on lipoxygenase and hyaluronidase activities with IC50 values 31.5 and 169     g/mL, respectively. Among the nine homoisoflavones tested, four (1 and 3-5) resulted in 79.3-97.9% higher lipoxygenase inhibition than 6.7-32.7% of the others at 500     M. Calculated IC50 values indicated 5 as the compound responsible for strong lipoxygenase inhibition with 15.8     M as the IC50 value. In the hyaluronidase assay, all homoisoflavones tested at 1000     M demonstrated 16.2-58.0% inhibition. Incubating the cells in the presence of all nine homoisoflavones tested at 50     M significantly suppressed the NO production, downward to 1.5-66.0%, in the LPS-activated macrophage cells as a model. DISCUSSION AND CONCLUSION: These results may indicate a potential role of S. scilloides for anti-inflammatory purposes.

title: Inhibitory effects of the XXXX extract from bulbs of Scilla scilloides on lipoxygenase and hyaluronidase activities.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity6400 :: ('MESH:D007529', 'Chemical') :: ['homoisoflavones']

entities_list: @entity1046 :: ('MESH:C007650', 'Chemical') :: ['ethyl acetate']

answer: @entity1046 :: (MESH:C007650,Chemical) :: ['ethyl acetate']


abstract: AIMS: The extended usage of unreamed tibial nailing resulted in reports of an increased rate of complications, especially for the distal portion of the @entity2091 . Unreamed nailing favours biology at the expense of the achievable mechanical stability, it is therefore of interest to define the limits of the clinical indications for this method. Extra-articular @entity174 of the distal tibial metaphysis, meta-diaphyseal junction, and adjacent diaphysis are distinct in their management from impaction derived '' @entity174 and @entity174 . The goals of this work were to gain a thorough understanding of the load-sharing mechanism between unreamed nail and bones in a @entity174 . With this purpose a complete model of the @entity1 leg was realised, simulating a mid-diaphyseal fracture, classified as A2 type 1, according to the AO classification. The analysis of the entire chain allows to have a complete picture of the stress distribution and of the most stressed bones and soft tissues, but, more importantly can overcome problems connected with boundary conditions imposed at single bony components. METHODS: Model consists of six bony structures: pelvis, femur, @entity12352 , fibula, @entity2091 , and a simplified lump of the feet, configured in a standing up position. Their articular cartilage layers, were simulated by 3D membranes of opportune stiffness connecting the different segments. Moreover an unreamed intra-medullary nail Expert Tibial Nail (DePuy Synthes(  )) stabilized the @entity174 . A load of 700  N has been applied at the top of pelvis and a part the feet, at the tip, was rigidly fixed. Five different contact interfaces have been imposed at the different bony surfaces in contact. RESULTS: Three different conditions were analysed: the initially healthy @entity2091 , the A2 type 1 @entity174 with the Expert tibial nail implanted, and the follow up stage after complete healing of @entity2091 . Non-linear finite element analysis of the models were performed with Abaqus version 5.4 (Hibbitt, Karlsson and Sorensen, Inc., Pawtucket, RI) using the geometric non linearity and automatic time stepping options. CONCLUSION: The obtained results reveal interesting consequences deriving by taking into account how the stress shielding can influence the integrity and resistance of bones, in order to identify the mechanical reasons for the unfavourable clinical results, and to identify borderline indications due to biomechanical factors. The evolution of treatment options for these @entity174 has been closely linked to developments in implant technology and surgical technique. Further developments in this area, particularly with respect to minimally invasive plating techniques and nail design are ongoing.

title: The healing stages of an intramedullary implanted XXXX : A stress strain comparative analysis of the calcification process.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fractured tibia', "pilon'' type fractures", 'mid-diaphyseal fractures']

answer: @entity2091 :: (MESH:C535563,Disease) :: ['tibia']


abstract: BACKGROUND: @entity2040 is one of the most prevalent @entity4801 worldwide and is a public health problem. @entity380 is the most widespread species responsible for @entity2040 in the Americas, Middle East and Africa. Adult female worms (mated to males) release eggs in the hepatic portal vasculature and are the principal cause of morbidity. Comparative separate transcriptomes of female and male adult worms were previously assessed with using microarrays and Serial Analysis of Gene Expression (SAGE), thus limiting the possibility of finding novel genes. Moreover, the egg transcriptome was analyzed only once with limited bacterially cloned cDNA libraries. METHODOLOGY/PRINCIPAL FINDINGS: To compare the gene expression of @entity383 eggs, females, and males, we performed RNA-Seq on these three parasite forms using 454/Roche technology and reconstructed the transcriptome using Trinity de novo assembly. The resulting contigs were mapped to the genome and were cross-referenced with predicted Smp genes and H3K4me3 ChIP-Seq public data. For the first time, we obtained separate, unbiased gene expression profiles for @entity383 eggs and female and male adult worms, identifying enriched biological processes and specific enriched functions for each of the three parasite forms. Transcripts with no match to predicted genes were analyzed for their protein-coding potential and the presence of an encoded conserved protein domain. A set of 232 novel protein-coding genes with putative functions related to reproduction, metabolism, and cell biogenesis was detected, which contributes to the understanding of parasite biology. CONCLUSIONS/SIGNIFICANCE: Large-scale RNA-Seq analysis using de novo assembly associated with genome-wide information for histone marks in the vicinity of gene models constitutes a new approach to transcriptome analysis that has not yet been explored in schistosomes. Importantly, all data have been consolidated into a UCSC Genome Browser search- and download-tool (http:// @entity380 .usp.br/). This database provides new ways to explore the schistosome genome and transcriptome and will facilitate molecular research on this important parasite.

title: XXXX Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA-Seq.

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic diseases']

entities_list: @entity380 :: ('6183', 'Species') :: ['Schistosoma mansoni', 'schistosoma']

entities_list: @entity2040 :: ('MESH:D012552', 'Disease') :: ['schistosomiasis', 'Schistosomiasis']

answer: @entity380 :: (6183,Species) :: ['Schistosoma mansoni']


abstract: OBJECTIVE: To determine the impact of processing delay, temperature, and transport tube type on results of quantitative bacterial culture (QBC) of @entity235 urine. DESIGN: Diagnostic test evaluation. SAMPLE: 60 mL of pooled urine from 4 @entity235 , divided into six 10-mL aliquots. PROCEDURES: Urine aliquots were spiked with bacteria from 1 of 6 independent @entity526 cultures to achieve a target bacterial concentration of 10(5) CFUs/mL. One milliliter from each aliquot was transferred into 5 @entity1346 -coated clot tubes (SCTs) and 5 urine transport tubes (UTTs). Samples were stored at 4  C (39  F) and 25  C (77  F) for 0, 8, and 24 hours, and then standard QBCs were performed. RESULTS: Median bacterial concentration for urine samples stored in a UTT for 24 hours at 4  C was lower than that for samples stored in an @entity12497 under the same conditions. Conversely, a substantial decrease in median bacterial concentration was identified for samples stored for 24 hours in an @entity12497 at 25  C, compared with the median concentration for samples stored in a UTT under the same conditions. Median bacterial concentration in samples stored in an @entity12497 at 25  C for 24 hours (275 CFUs/mL) was less than the cutoff typically used to define clinically important @entity793 by use of urine samples obtained via cystocentesis (ie, > 1,000 CFUs/mL). CONCLUSIONS AND CLINICAL RELEVANCE: @entity235 urine samples submitted for immediate QBC should be transported in plain sterile tubes such as SCTs. When prolonged (24-hour) storage at room temperature is anticipated, urine samples should be transported in UTTs.

title: Effects of processing delay, temperature, and transport tube type on results of quantitative bacterial culture of XXXX urine.

entities_list: @entity235 :: ('9615', 'Species') :: ['canine', 'Canine', 'dogs']

entities_list: @entity793 :: ('MESH:D001437', 'Disease') :: ['bacteriuria']

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity235 :: (9615,Species) :: ['canine']


abstract: Importance: Topical @entity23782 therapy is used to treat symptomatic @entity102 ( @entity102 ). However, the potential adverse impact of this therapy on the sinus microbiota has not been well quantified. Objective: To determine changes in microbiologic culture results before and after topical @entity23782 therapy in @entity1 with @entity102 with medically and surgically refractory disease. Design, Setting, and @entity1 : We performed a retrospective medical chart review for 22 consecutive adults evaluated and treated between January 1, 2012, and January 1, 2014, at an otolaryngology-rhinology clinic at a regional academic medical center. The @entity1 were 14 @entity1 and 8 @entity1 , who had undergone functional endoscopic sinus surgery for @entity102 , and in whom sinus aspirate cultures were performed before and after topical @entity23782 therapy for symptomatic disease. Analyses were performed in April 2014. Exposures: @entity1 underwent treatment with saline sinus rinse, with the addition of @entity23782 , for at least 1 week. Main Outcomes and Measures: Bacterial isolates from sinus aspirate culture. Results: The @entity1 included 14 @entity1 and 8 @entity1 , 18 to 75 years old, who underwent a mean of 1.9 functional endoscopic sinus surgical procedures. The mean (range) duration of @entity23782 therapy was 6 (2-12) weeks. Before @entity23782 therapy, cultures from symptomatic @entity1 (14 @entity1 and 8 @entity1 , ages 18-75 years) revealed common bacteria implicated in @entity102 , which are characteristically gram-positive. After @entity23782 therapy, cultures from symptomatic @entity1 shifted significantly: 19 were gram-positive vs 3 gram-negative before treatment; 9 were gram-positive vs 13 gram-negative after treatment (P   =   .004), with increased growth of pathogenic gram-negative bacteria and Corynebacterium. Conclusions and Relevance: These data present evidence supporting the distinct abrogation of culturable sinus bacteria after @entity23782 rinses, identifying a shift toward increased pathogenic bacteria. Consideration of healthy host microbiome and @entity1200 should guide future treatment considerations.

title: Alteration in Bacterial Culture After Treatment With Topical XXXX for Recalcitrant @entity102 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'Participants', 'men']

entities_list: @entity23782 :: ('MESH:D016712', 'Chemical') :: ['mupirocin']

entities_list: @entity1200 :: ('MESH:D007154', 'Disease') :: ['immune dysfunction']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['CRS', 'chronic sinusitis']

answer: @entity23782 :: (MESH:D016712,Chemical) :: ['Mupirocin']


abstract: Importance: Topical @entity23782 therapy is used to treat symptomatic @entity102 ( @entity102 ). However, the potential adverse impact of this therapy on the sinus microbiota has not been well quantified. Objective: To determine changes in microbiologic culture results before and after topical @entity23782 therapy in @entity1 with @entity102 with medically and surgically refractory disease. Design, Setting, and @entity1 : We performed a retrospective medical chart review for 22 consecutive adults evaluated and treated between January 1, 2012, and January 1, 2014, at an otolaryngology-rhinology clinic at a regional academic medical center. The @entity1 were 14 @entity1 and 8 @entity1 , who had undergone functional endoscopic sinus surgery for @entity102 , and in whom sinus aspirate cultures were performed before and after topical @entity23782 therapy for symptomatic disease. Analyses were performed in April 2014. Exposures: @entity1 underwent treatment with saline sinus rinse, with the addition of @entity23782 , for at least 1 week. Main Outcomes and Measures: Bacterial isolates from sinus aspirate culture. Results: The @entity1 included 14 @entity1 and 8 @entity1 , 18 to 75 years old, who underwent a mean of 1.9 functional endoscopic sinus surgical procedures. The mean (range) duration of @entity23782 therapy was 6 (2-12) weeks. Before @entity23782 therapy, cultures from symptomatic @entity1 (14 @entity1 and 8 @entity1 , ages 18-75 years) revealed common bacteria implicated in @entity102 , which are characteristically gram-positive. After @entity23782 therapy, cultures from symptomatic @entity1 shifted significantly: 19 were gram-positive vs 3 gram-negative before treatment; 9 were gram-positive vs 13 gram-negative after treatment (P   =   .004), with increased growth of pathogenic gram-negative bacteria and Corynebacterium. Conclusions and Relevance: These data present evidence supporting the distinct abrogation of culturable sinus bacteria after @entity23782 rinses, identifying a shift toward increased pathogenic bacteria. Consideration of healthy host microbiome and @entity1200 should guide future treatment considerations.

title: Alteration in Bacterial Culture After Treatment With Topical @entity23782 for Recalcitrant XXXX .

answer: @entity102 :: (MESH:D002908,Disease) :: ['Chronic Rhinosinusitis']


abstract: Importance: @entity810 ( @entity810 ) affects as many as 40% of @entity1 undergoing surgery and is associated with increased all-cause mortality. @entity740 ( @entity740 ) is a well-known risk factor for cardiovascular mortality. Objective: To determine the association between @entity8 and long-term cardiovascular-specific mortality after vascular surgery. Design, Setting, and @entity1 : A single-center cohort of 3646 @entity1 underwent inpatient vascular surgery from January 1, 2000, to November 30, 2010, at a tertiary care teaching hospital. To determine cause-specific mortality for @entity1 undergoing vascular surgery, a proportional subdistribution hazards regression analysis was used to model long-term cardiovascular-specific mortality while treating any other cause of @entity204 as a competing risk. @entity8 constituted the main covariate after adjusting for baseline @entity1 characteristics, surgery type, and admission hemoglobin level. Final follow-up was completed July 2014 to assess survival through January 31, 2014, and data were analyzed from June 1, 2014, to September 7, 2015. Main Outcomes and Measures: Perioperative @entity810 , presence of @entity740 , and overall and cause-specific mortality. Results: Among the 3646 @entity1 undergoing vascular surgery, perioperative @entity810 occurred in 1801 (49.4%) and @entity740 was present in 496 (13.6%). The top 2 causes among the 1577 @entity204 in our cohort were @entity65 (845 of 1577 [53.6%]) and @entity5 (173 of 1577 [11.0%]). Adjusted cardiovascular mortality estimates at 10 years were 17%, 31%, 30%, and 41%, respectively, for @entity1 with no @entity8 , @entity810 without @entity740 , @entity740 without @entity810 , and @entity810 with @entity740 . Adjusted hazard ratios (95% CIs) for cardiovascular mortality were significantly elevated among @entity1 with @entity810 without @entity740 (2.07 [1.74-2.45]), @entity740 without @entity810 (2.01 [1.46-2.78]), and @entity810 with @entity740 (2.99 [2.37-3.78]) and were higher than those for other risk factors, including increasing age (1.03 per 1-year increase; 1.02-1.04), emergent surgery (1.47; 1.27-1.71), and admission hemoglobin levels lower than 10 g/dL (1.39; 1.14-1.69) compared with a hemoglobin level of 12 g/dL or higher. Conclusions and Relevance: Perioperative @entity810 is common in @entity1 undergoing vascular surgery and is associated with a high risk for cardiovascular-specific mortality comparable to that seen with @entity740 . These findings reinforce the importance of preoperative and postoperative risk stratification for @entity8 and the implementation of strategies now available to help prevent perioperative @entity810 .

title: Cardiovascular-Specific Mortality and XXXX in @entity1 Undergoing Vascular Surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Participants']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Kidney disease', 'kidney disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease', 'CKD']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'Acute kidney injury']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity8 :: (MESH:D007674,Disease) :: ['Kidney Disease']


abstract: Importance: @entity810 ( @entity810 ) affects as many as 40% of @entity1 undergoing surgery and is associated with increased all-cause mortality. @entity740 ( @entity740 ) is a well-known risk factor for cardiovascular mortality. Objective: To determine the association between @entity8 and long-term cardiovascular-specific mortality after vascular surgery. Design, Setting, and @entity1 : A single-center cohort of 3646 @entity1 underwent inpatient vascular surgery from January 1, 2000, to November 30, 2010, at a tertiary care teaching hospital. To determine cause-specific mortality for @entity1 undergoing vascular surgery, a proportional subdistribution hazards regression analysis was used to model long-term cardiovascular-specific mortality while treating any other cause of @entity204 as a competing risk. @entity8 constituted the main covariate after adjusting for baseline @entity1 characteristics, surgery type, and admission hemoglobin level. Final follow-up was completed July 2014 to assess survival through January 31, 2014, and data were analyzed from June 1, 2014, to September 7, 2015. Main Outcomes and Measures: Perioperative @entity810 , presence of @entity740 , and overall and cause-specific mortality. Results: Among the 3646 @entity1 undergoing vascular surgery, perioperative @entity810 occurred in 1801 (49.4%) and @entity740 was present in 496 (13.6%). The top 2 causes among the 1577 @entity204 in our cohort were @entity65 (845 of 1577 [53.6%]) and @entity5 (173 of 1577 [11.0%]). Adjusted cardiovascular mortality estimates at 10 years were 17%, 31%, 30%, and 41%, respectively, for @entity1 with no @entity8 , @entity810 without @entity740 , @entity740 without @entity810 , and @entity810 with @entity740 . Adjusted hazard ratios (95% CIs) for cardiovascular mortality were significantly elevated among @entity1 with @entity810 without @entity740 (2.07 [1.74-2.45]), @entity740 without @entity810 (2.01 [1.46-2.78]), and @entity810 with @entity740 (2.99 [2.37-3.78]) and were higher than those for other risk factors, including increasing age (1.03 per 1-year increase; 1.02-1.04), emergent surgery (1.47; 1.27-1.71), and admission hemoglobin levels lower than 10 g/dL (1.39; 1.14-1.69) compared with a hemoglobin level of 12 g/dL or higher. Conclusions and Relevance: Perioperative @entity810 is common in @entity1 undergoing vascular surgery and is associated with a high risk for cardiovascular-specific mortality comparable to that seen with @entity740 . These findings reinforce the importance of preoperative and postoperative risk stratification for @entity8 and the implementation of strategies now available to help prevent perioperative @entity810 .

title: Cardiovascular-Specific Mortality and @entity8 in XXXX Undergoing Vascular Surgery.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: AIM: This study aims to evaluate the clinical efficacy and safety of intravenous Cefoselis injection for the treatment of acute moderate and severe @entity2348 . @entity1 AND METHODS: A multicenter, double-blind, randomized clinical trial was carried out using Cefepime as control. @entity1 received 1.0 g of either Cefoselis or Cefepime for moderate @entity281 or 2.0 g for severe @entity281 at an interval of 12 hours for 7 to 14 days. A total of 276 @entity1 (138 with Cefoselis, 138 with Cefepime) with @entity1729 were enrolled in the study. Up to 137 and 124 @entity1 receiving Cefoselis and 132 and 125 @entity1 receiving Cefepime were eligible for the ITT (intent to treat) and PP (per protocol) analyses, respectively. RESULTS: At the end of the treatment, the cure rates and effective rates were 59.68% (74/124) and 93.55% (116/124) with Cefoselis, and 56.00% (74/124) and 90.40% (116/124) with Cefepime. The bacterial eradication rates of the two groups were 90.32% and 93.85%, respectively. No statistical differences were observed on the above-mentioned parameters between the two groups (all p > 0.05). Adverse events, mainly mild aminotransferase elevation and mild @entity1431 , were observed in 11.59% (16/138) and 13.77% (19/138) of @entity1 with Cefoselis and @entity6944 , respectively (p > 0.05). CONCLUSIONS: Cefoselis is an effective and safe choice against acute moderate and severe @entity1729 and @entity293 ( @entity293 ).

title: Multicenter, double-blind, randomized clinical trial of parenterally administered Cefoselis versus Cefepime for the treatment of acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity6944 :: ('MESH:C043266', 'Chemical') :: ['Cefepime']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infections', 'respiratory or urinary tract infections']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection', 'UTI']

answer: @entity2348 :: (MESH:D001424,Disease) :: ['bacterial infections']


abstract: OBJECTIVE: The present double-blind randomized clinical trial aimed to compare the efficacy in reducing dentin @entity56 of a dentifrice formulation containing nano- @entity692 with a @entity1388 dentifrice and a placebo. METHOD AND MATERIALS: 105 subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: 1) nano- @entity692 15% toothpaste, @entity1388 -free; 2) @entity1388 toothpaste; 3) placebo. Groups 1, 2, and 3 were instructed to brush their teeth for 2 minutes twice a day with the provided toothpaste. The @entity1 's dentin @entity56 was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analog scale (VAS) was used. RESULTS: Significantly lower values of cold air sensitivity and tactile sensitivity (P<.001) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significantly (P<.001) lower values of sensitivity were reported for group 1 compared to groups 2 and 3, at 2 and 4 weeks respectively. The VAS scores were significantly lower (P<.001) in the test group at 2 and 4 weeks compared to baseline and to the control groups. CONCLUSION: The findings of the present study encourage the application of nano- @entity692 in @entity1388 -free toothpaste as an effective desensitizing agent providing quick relief from symptoms after 2 and 4 weeks.

title: Effectiveness of nano- @entity692 toothpaste in reducing dentin XXXX : a double-blind randomized controlled trial.

entities_list: @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite']

entities_list: @entity1 :: ('9606', 'Species') :: ['participant']

entities_list: @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity']

answer: @entity56 :: (MESH:D004342,Disease) :: ['hypersensitivity']


abstract: OBJECTIVE: The present double-blind randomized clinical trial aimed to compare the efficacy in reducing dentin @entity56 of a dentifrice formulation containing nano- @entity692 with a @entity1388 dentifrice and a placebo. METHOD AND MATERIALS: 105 subjects were recruited to participate in the study. A computer-generated random table with blocking to one of the three study treatments was used in order to have 35 subjects per group: 1) nano- @entity692 15% toothpaste, @entity1388 -free; 2) @entity1388 toothpaste; 3) placebo. Groups 1, 2, and 3 were instructed to brush their teeth for 2 minutes twice a day with the provided toothpaste. The @entity1 's dentin @entity56 was evaluated at baseline and after 2 and 4 weeks using airblast and tactile tests. In addition, a subjective evaluation using a visual analog scale (VAS) was used. RESULTS: Significantly lower values of cold air sensitivity and tactile sensitivity (P<.001) were found for the test group at 2 weeks and 4 weeks. In addition, statistically significantly (P<.001) lower values of sensitivity were reported for group 1 compared to groups 2 and 3, at 2 and 4 weeks respectively. The VAS scores were significantly lower (P<.001) in the test group at 2 and 4 weeks compared to baseline and to the control groups. CONCLUSION: The findings of the present study encourage the application of nano- @entity692 in @entity1388 -free toothpaste as an effective desensitizing agent providing quick relief from symptoms after 2 and 4 weeks.

title: Effectiveness of nano- XXXX toothpaste in reducing dentin @entity56 : a double-blind randomized controlled trial.

answer: @entity692 :: (MESH:D017886,Chemical) :: ['hydroxyapatite']


abstract: @entity358 is a @entity364 endemic to the desert regions of the southwestern United States, Mexico, Central America, and South America. The incidence of reported disease increased substantially between 1998 and 2011, and the @entity281 is encountered beyond the endemic areas because of a mobile society. The disease is caused by inhalation of spores of Coccidioides species. Individuals at high risk are those exposed to frequent soil aerosolization. The diagnosis is established by direct visualization of mature spherules by using special stains or cultures from biologic specimens. Serologic testing of anticoccidioidal antibodies is used for diagnosis and treatment monitoring. The @entity281 is self-limited in 60% of cases. When the disease is symptomatic, the lung is the primary site of involvement. On the basis of clinical presentation and imaging abnormalities, @entity358 is categorized into acute, disseminated, and chronic forms, each with a spectrum of imaging findings. In @entity1 with @entity697 , the most common findings are lobar or segmental consolidation, multifocal consolidation, and nodules. Adenopathy and @entity1143 are also seen, usually in association with parenchymal disease. @entity66 is rare and occurs in less than 1% of @entity1 . Pulmonary findings are miliary nodules and confluent parenchymal opacities. Acute @entity649 is an infrequent complication of disseminated disease. The acute findings resolve in most @entity1 , with chronic changes developing in approximately 5% of @entity1 . Manifestations of @entity102 include residual nodules, chronic @entity6675 , persistent @entity55 with or without adenopathy, @entity1143 , and regressive changes. Unusual complications of @entity102 are @entity13443 , @entity733 formation, and @entity292 . @entity1 in an immunocompromised state, those with @entity6 , pregnant @entity1 , and those belonging to certain ethnic groups may show severe, progressive, or disseminated disease.

title: XXXX : pictorial review of chest radiographic and CT findings.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Patients']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion', 'pleural effusions']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute disease']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Disseminated disease']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal disease']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['Pulmonary coccidioidomycosis', 'pulmonary involvement']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['bronchopleural fistula']

answer: @entity358 :: (MESH:D008171,Disease) :: ['Pulmonary coccidioidomycosis']


abstract: @entity4617 in @entity1 are rare, are more commonly benign, and differ in types when compared with those in adults. @entity4618 , @entity44 , and @entity81 are the most common @entity4617 in fetuses and neonates. In @entity1 and @entity1 , the most common @entity4617 are @entity4618 and @entity81 , which are benign primary @entity4617 , whereas in adults, @entity715 is the most common cardiac mass and @entity3291 is the most common primary @entity4617 . @entity242 are the most common primary @entity4617 in both @entity1 and adults. Metastatic @entity4617 are less common in @entity1 than in adults and include @entity242 , @entity706 , @entity5 , and @entity3969 . @entity1 with @entity4617 can be asymptomatic or may present with murmur, @entity943 , @entity712 , or @entity944 . Echocardiography is the primary modality for initial evaluation of symptomatic @entity1 . Cardiac magnetic resonance imaging provides further characterization of cardiac masses and @entity5 for diagnostic purposes and can be used to assess cardiac and extracardiac involvement for treatment planning. Treatment varies from conservative management or surgical resection to transplantation, depending on the diagnosis and the @entity1 's symptoms. @entity4618 typically regresses spontaneously during early childhood and does not require surgical intervention if asymptomatic. However, @entity81 is generally resected because it does not regress. An understanding of the types of @entity4617 that occur in @entity1 and @entity1 , their clinical implications and associations, and their imaging appearances will facilitate @entity1 management.

title: XXXX : clinical and imaging features.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'infants', 'Patients', 'children', 'patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'Sarcomas']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'testicular cancer']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity4617 :: ('MESH:D006338', 'Disease') :: ['cardiac tumors', 'malignant cardiac tumors', 'cardiac tumor', 'Cardiac tumors']

entities_list: @entity4618 :: ('MESH:D012207', 'Disease') :: ['Rhabdomyoma', 'rhabdomyoma']

entities_list: @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumor']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity81 :: ('MESH:D005350', 'Disease') :: ['fibroma']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratoma']

answer: @entity4617 :: (MESH:D006338,Disease) :: ['Pediatric cardiac tumors']


abstract: BACKGROUND: @entity1 with @entity1278 ( @entity1278 ) have @entity51 in @entity1442 ( @entity1442 ) and central coherence (CC) consistent with an inflexible thinking style and overly detailed processing style, respectively. This study investigates brain activation during @entity1442 and CC tasks in @entity1 with @entity1278 and tests whether this activation is a biomarker that predicts response to treatment. METHODS: FMRI data were collected from 21 females with @entity1278 while performing an @entity1442 task (the Wisconsin Card Sort) and a CC task (embedded figures), and used to predict outcome following 16 weeks of treatment (either 16 weeks of cognitive behavioral therapy or 8 weeks cognitive remediation therapy followed by 8 weeks of cognitive behavioral therapy). RESULTS: Significant activation during the @entity1442 task included bilateral dorsolateral and ventrolateral prefrontal cortex and left anterior middle frontal gyrus. Higher scores on the neuropsychological test of @entity1442 (measured outside the scanner at baseline) were correlated with greater DLPFC and VLPFC/insula activation. Improvements in @entity1442 following treatment were significantly predicted by a combination of low VLPFC/insula and high anterior middle frontal activation (R squared  =  .68, p  =  .001). For the CC task, visual and parietal cortical areas were activated, but were not significantly correlated with neuropsychological measures of CC and did not predict outcome. CONCLUSION: Cognitive flexibility requires the support of several prefrontal cortex resources. As previous studies suggest that the VLPFC is important for selecting context-appropriate responses, @entity1 who have difficulties with this skill may benefit the most from cognitive therapy with or without cognitive remediation therapy. The ability to sustain inhibition of an unwanted response, subserved by the anterior middle frontal gyrus, is a cognitive feature that predicts favorable outcome to cognitive treatment. @entity51 may not be an effective predictor of clinical outcome.

title: Predicting clinical outcome using brain activation associated with set-shifting and central coherence skills in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['CC deficits', 'neuropsychological deficits']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['SS', 'Set-Shifting']

entities_list: @entity1278 :: ('MESH:D000856', 'Disease') :: ['AN', 'Anorexia Nervosa']

answer: @entity1278 :: (MESH:D000856,Disease) :: ['Anorexia Nervosa']


abstract: BACKGROUND: Age, estimated @entity8 ( @entity470 ), and ejection fraction are preprocedural predictors of contrast-induced @entity810 (CI-AKI) after primary percutaneous coronary intervention. The effect of renal function-adjusted contrast volume (CV) remains not totally explored, and a threshold has not yet been established. METHODS AND RESULTS: Logistic regression and receiver-operating characteristic curve analyses were used to assess whether CV/ @entity470 was an independent predictor of CI-AKI. The increased discriminative value of CV/ @entity470 over the preprocedural model based on age, @entity470 , and ejection fraction was examined using the net reclassification improvement analysis. Of 470 @entity1 enrolled, we observed 25 (5.3%) cases of CI-AKI. @entity1 with CI-AKI had received a higher renal function-adjusted CV (CV/ @entity470 3.62 versus 1.96; P<0.001), and CI-AKI incidence was higher (15%; P<0.001) in @entity1 in the highest quartile of CV/ @entity470 , corresponding to the cutoff indicated by the receiver-operating characteristic curve (>2.5; area under the curve, 0.77). At multivariable analysis, CV/ @entity470 above the cutoff (odds ratio, 5.57; P=0.002) remained an independent predictor of CI-AKI. The model with CV/ @entity470 demonstrated a statistically significantly net reclassification improvement of 0.23 (P=0.021) over the baseline preprocedural model, largely driven by a correct decrease in risk estimates for @entity1 not experiencing CI-AKI, with a likelihood ratio   (2) of 5.973 (P=0.029). CONCLUSIONS: CV remains a key risk factor for CI-AKI after primary percutaneous coronary intervention and our study supports the need for minimizing CV, independently from baseline preprocedural risk. A CV restricted to no more than twice and a half the baseline @entity470 might be valuable in reducing the risk of CI-AKI.

title: Renal function-adjusted contrast volume redefines the baseline estimation of contrast-induced XXXX risk in @entity1 undergoing primary percutaneous coronary intervention.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular renal function']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury']

answer: @entity810 :: (MESH:D058186,Disease) :: ['acute kidney injury']


abstract: BACKGROUND: Age, estimated @entity8 ( @entity470 ), and ejection fraction are preprocedural predictors of contrast-induced @entity810 (CI-AKI) after primary percutaneous coronary intervention. The effect of renal function-adjusted contrast volume (CV) remains not totally explored, and a threshold has not yet been established. METHODS AND RESULTS: Logistic regression and receiver-operating characteristic curve analyses were used to assess whether CV/ @entity470 was an independent predictor of CI-AKI. The increased discriminative value of CV/ @entity470 over the preprocedural model based on age, @entity470 , and ejection fraction was examined using the net reclassification improvement analysis. Of 470 @entity1 enrolled, we observed 25 (5.3%) cases of CI-AKI. @entity1 with CI-AKI had received a higher renal function-adjusted CV (CV/ @entity470 3.62 versus 1.96; P<0.001), and CI-AKI incidence was higher (15%; P<0.001) in @entity1 in the highest quartile of CV/ @entity470 , corresponding to the cutoff indicated by the receiver-operating characteristic curve (>2.5; area under the curve, 0.77). At multivariable analysis, CV/ @entity470 above the cutoff (odds ratio, 5.57; P=0.002) remained an independent predictor of CI-AKI. The model with CV/ @entity470 demonstrated a statistically significantly net reclassification improvement of 0.23 (P=0.021) over the baseline preprocedural model, largely driven by a correct decrease in risk estimates for @entity1 not experiencing CI-AKI, with a likelihood ratio   (2) of 5.973 (P=0.029). CONCLUSIONS: CV remains a key risk factor for CI-AKI after primary percutaneous coronary intervention and our study supports the need for minimizing CV, independently from baseline preprocedural risk. A CV restricted to no more than twice and a half the baseline @entity470 might be valuable in reducing the risk of CI-AKI.

title: Renal function-adjusted contrast volume redefines the baseline estimation of contrast-induced @entity810 risk in XXXX undergoing primary percutaneous coronary intervention.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Small-cell @entity263 is an aggressive @entity5 whose rarity has prevented the development of a consensus management approach. The objective of the current study was to determine the treatment patterns and evaluate factors affecting overall survival for @entity1 with localized small-cell @entity263 . METHODS: After querying the National @entity5 Database, we identified all @entity1 diagnosed with localized small-cell @entity263 between 1998 and 2011 (n=287). Using Kaplan-Meier curves and Cox regression analyses, we assessed the effect of treatment and clinical stage on overall survival. RESULTS: Treatments included radiation therapy in 46% (n=131), chemotherapy in 38% (n=107), @entity342 deprivation therapy (ADT) in 22% (n=63) and radical prostatectomy in 13% (n=38). Median overall survival was 14.8 months. Upon multivariate analysis, local therapy (radical prostatectomy or radiation therapy) was associated with improved survival (hazard ratio (HR) 0.23, 95% confidence interval (CI) 0.14-0.38, P<0.001). Advanced clinical stage predicted worse survival among all @entity1 ( @entity16178 : HR 2.83, 95% CI 1.27-6.32, P=0.011; cT4: HR 3.26, 95% CI 1.50-7.07, P=0.003) and @entity1 who received local therapy ( @entity16178 : HR 4.67, 95% CI 1.41-15.44, P=0.012; cT4: HR 4.01, 95% CI 1.14-14.08, P=0.03) but not among @entity1 who received no local therapy ( @entity16178 : HR 1.64, 95% CI 0.51-5.27, P=0.4; cT4: HR 2.35, 95% CI 0.74-7.48, P=0.15). Age, receipt of chemotherapy and ADT, and clinical stage T2 disease (compared with T1) did not predict survival. CONCLUSION: @entity1 with localized small-cell @entity263 have a poor overall survival. Local therapy may represent a suitable and underused modality for select @entity1 .

title: Population-based analysis of treatment modalities and survival for clinically localized small-cell XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Men', 'men']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['carcinoma of the prostate']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['carcinoma of the prostate']


abstract: UNASSIGNED: @entity52680 is a rare, benign disease that is characterized by a local but not metastatic invasivity. In particular, @entity765 of the chest wall represent only 10-20% of all deep @entity81 . The disease occurs more often in females and has a higher incidence between puberty and the fourth decade of life. The present study reports the case of a 34-year-old female who came to our attention due to a voluminous mass in the right subcostal region. The magnetic resonance imaging of the upper abdomen confirmed the presence of a @entity5 localized between the anterior hepatic margin and the right costal plane. Through a right subcostal laparotomy, the voluminous 95*45*94-mm @entity5 was excised. Histological examination showed evidence consistent with @entity52680 . The @entity1 has not shown recurrence of the disease for 4 years since the surgery. Overall, radical surgery with disease-free resection margins is the prime treatment option for this disease. Other therapeutic options, such as radiotherapy, hormonal therapy or treatment with @entity2213 , can also be considered in certain cases.

title: XXXX : Clinical and therapeutic considerations based on an illustrative case.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm']

entities_list: @entity765 :: ('MESH:D018222', 'Disease') :: ['desmoid tumors']

entities_list: @entity52680 :: ('MESH:D018221', 'Disease') :: ['Extra-abdominal fibromatosis', 'extra-abdominal fibromatosis']

entities_list: @entity81 :: ('MESH:D005350', 'Disease') :: ['fibromatoses']

entities_list: @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib mesylate']

answer: @entity52680 :: (MESH:D018221,Disease) :: ['Extra-abdominal fibromatosis']


abstract: Introduction   Numerous surgical methods are used to treat nasal obstruction due to inferior turbinate @entity1184 . The primary goal of the therapy is to maximize the nasal airway for as extended a period of time as possible while minimizing therapeutic complications. Objectives   The aim of this study was to assess the effects of radiofrequency thermal ablation (RFTA) and bipolar electrocautery (BEC) on the removal of nasal obstruction in @entity1 with inferior turbinate @entity1184 and on nasal mucociliary clearance (MCC). @entity1 in both groups were also evaluated in terms of postoperative morbidity. Methods   We compared the outcomes of two groups of @entity1 : those treated with RFTA (n   =   23) and those who underwent BEC (n   =   20). Nasal obstruction was graded using a visual analog scale (VAS) and MCC was measured using a @entity8021 clearance test. Both measurements were performed before and 2 months after treatment. Results   Pre- and postoperative VAS scores showed significant improvement for both groups. However, MCC results did not significantly differ between two groups. Neither @entity4 nor crust formation persisted for more than 1   week in any @entity1 . Conclusion   Submucosal cauterization with preservation of the nasal mucosa and periosteum is as effective and safe as RFTA and should be considered when planning inferior turbinate interventions.

title: Radiofrequency Thermal Ablation versus Bipolar Electrocautery for the Treatment of Inferior Turbinate XXXX : Comparison of Efficacy and Postoperative Morbidity.

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity8021 :: ('MESH:D012439', 'Chemical') :: ['saccharin']

answer: @entity1184 :: (MESH:D006984,Disease) :: ['Hypertrophy']


abstract: Introduction   The relevance of @entity2023 is unquestionable. This condition affects @entity1 's quality of life and its incidence has increased over the last years. Objective   Thus, this study aims to analyze the effectiveness of subcutaneous injectable immunotherapy in cases of nasal itching, sneeze, @entity5254 and nasal congestion in @entity2023 @entity1 . Methods   In the present study, the same researcher analyzed the records of 281 @entity1 . Furthermore, the researchers identified allergens through puncture cutaneous tests using standardized extracts containing acari, fungi, pet hair, flower pollen, and feathers. Then, the @entity1 underwent treatment with subcutaneous specific immunotherapy, using four vaccine vials for desensitization, associated with environmental hygiene. The authors analyzed conditions of nasal itching, sneeze, @entity5254 , and nasal congestion throughout the treatment, and assigned them with a score ranging from zero (0), meaning absence of these symptoms to three (3), for severe cases. The symptoms were statistically compared in the beginning, during, and after treatment. Results   In this study, authors analyzed the cases distribution according to age and the evolution of symptomatology according to the scores, comparing all phases of treatment. The average score for the entire population studied was 2.08 before treatment and 0.44 at the end. These results represent an overall improvement of    79% in symptomatology of @entity2023 in the studied population. Conclusion   The subcutaneous immunotherapy as treatment of @entity2023 led to a reduction in all symptoms studied, improving the quality of life of @entity1 , proving itself as an important therapeutic tool for these pathological conditions.

title: Subcutaneous Immunotherapy Improves the Symptomatology of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['people', 'patients']

entities_list: @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis']

answer: @entity2023 :: (MESH:D006255,Disease) :: ['Allergic Rhinitis']


abstract: PURPOSE: To review the diagnosis and treatment of @entity378 of the sternoclavicular joint in 13 @entity1 . METHODS: Records of 9 @entity1 and 4 @entity1 aged 26 to 47 (mean, 36.5) years who presented with @entity378 of the right (n=8) or left (n=5) sternoclavicular joint were reviewed. RESULTS: All 13 @entity1 had a raised erythrocyte sedimentation rate at presentation. Nine @entity1 presented with systemic symptoms including malaise, @entity221 , or loss of weight/appetite. Local symptoms included @entity733 (n=5), tenderness and non-fluctuant swelling (n=4), and discharging sinus (n=4). The mean duration of symptoms was 2.7 (range, 1-7) months. Four @entity1 had multifocal involvement of the proximal ulna (n=1), lung (n=2), and meninges (n=1). Aspiration (n=3), fine needle aspiration cytology (n=4), drainage (n=2), or curettage (n=4) of the swelling, @entity733 , or sinus was performed, and the diagnosis was confirmed by histopathology (n=8), polymerase chain reaction (n=5), or culture (n=1). Two @entity1 were diagnosed based on clinical suspicion. 11 @entity1 responded to antituberculous therapy (ATT), and symptoms resolved after 6 to 8 weeks. Two @entity1 did not respond to ATT after 3 months and were screened for immunocompromising disorders or drug resistance. Their @entity404 count and @entity404 : @entity405 ratio was low, and an immunomodulation regimen was prescribed as an adjunct to ATT. CONCLUSION: A high level of clinical suspicion is needed to diagnose @entity378 of the sternoclavicular joint in @entity1 with @entity158 /tenderness, discharging sinus, or @entity733 . A combination of histopathological and microbiological tests, and PCR can confirm the diagnosis.

title: XXXX of the sternoclavicular joint.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity733 :: ('MESH:D000038', 'Disease') :: ['cold abscess', 'abscess']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

answer: @entity378 :: (MESH:D014376,Disease) :: ['Tuberculosis']


abstract: PURPOSE: @entity15127 has been shown to be effective in treating @entity1103 ( @entity1103 ). In the original Phase II/III trial, however, @entity1 with @entity63 were excluded. In this study, we treated @entity1 with @entity63 @entity1103 . METHODS: @entity63 was defined as a 30% increase in the area of the foveal avascular zone (FAZ) at 45 seconds on fundus @entity941 angiography. In addition, the @entity1 had diffuse foveal-involving @entity1103 with a central subfield thickness (CST) of >300  m on spectral-domain optical coherence tomography. Five intravitreal @entity15127 injections were given 6 weeks apart. The final study visit was 6 weeks after the fifth injection. The primary outcome was change in the size of FAZ. Secondary outcomes were change in best-corrected visual acuity (BCVA) and the change in CST. RESULTS: Thirty @entity1 were enrolled. Three were unable to complete the full course of treatment. Their outcomes were carried forward for the first part of this analysis. There was no statistically significant change in the mean size of the FAZ from baseline to the final visit. Subclassifying @entity1 as those with minimal/moderate @entity63 (16 @entity1 , FAZ area <1,000 pixels) and those with more severe @entity63 (14 @entity1 , FAZ area >1,000 pixels) also showed no statistically significant change in the mean area of the FAZ. On average, BCVA increased and CST decreased from baseline to the final visit, but these changes were not statistically significant. Using per protocol analysis on those @entity1 who completed the full course of treatment, the mean BCVA increased from 49.2 to 53.9 letters (P=0.046). CONCLUSION: In this study, intravitreal injection of @entity15127 did not significantly alter the size of the FAZ in @entity1 with varying degrees of @entity63 @entity1103 . There was, however, a significant improvement in mean BCVA in those who completed the treatment course.

title: Intravitreal @entity15127 for the treatment of @entity63 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity15127 :: ('MESH:C495058', 'Chemical') :: ['Pegaptanib', 'pegaptanib']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['Macular ischemia', 'ischemia', 'macular ischemia', 'ischemic']

entities_list: @entity1103 :: ('MESH:D008269', 'Disease') :: ['DME', 'diabetic macular edema']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

answer: @entity1103 :: (MESH:D008269,Disease) :: ['diabetic macular edema']


abstract: PURPOSE: @entity15127 has been shown to be effective in treating @entity1103 ( @entity1103 ). In the original Phase II/III trial, however, @entity1 with @entity63 were excluded. In this study, we treated @entity1 with @entity63 @entity1103 . METHODS: @entity63 was defined as a 30% increase in the area of the foveal avascular zone (FAZ) at 45 seconds on fundus @entity941 angiography. In addition, the @entity1 had diffuse foveal-involving @entity1103 with a central subfield thickness (CST) of >300  m on spectral-domain optical coherence tomography. Five intravitreal @entity15127 injections were given 6 weeks apart. The final study visit was 6 weeks after the fifth injection. The primary outcome was change in the size of FAZ. Secondary outcomes were change in best-corrected visual acuity (BCVA) and the change in CST. RESULTS: Thirty @entity1 were enrolled. Three were unable to complete the full course of treatment. Their outcomes were carried forward for the first part of this analysis. There was no statistically significant change in the mean size of the FAZ from baseline to the final visit. Subclassifying @entity1 as those with minimal/moderate @entity63 (16 @entity1 , FAZ area <1,000 pixels) and those with more severe @entity63 (14 @entity1 , FAZ area >1,000 pixels) also showed no statistically significant change in the mean area of the FAZ. On average, BCVA increased and CST decreased from baseline to the final visit, but these changes were not statistically significant. Using per protocol analysis on those @entity1 who completed the full course of treatment, the mean BCVA increased from 49.2 to 53.9 letters (P=0.046). CONCLUSION: In this study, intravitreal injection of @entity15127 did not significantly alter the size of the FAZ in @entity1 with varying degrees of @entity63 @entity1103 . There was, however, a significant improvement in mean BCVA in those who completed the treatment course.

title: Intravitreal @entity15127 for the treatment of XXXX @entity1103 .

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemic']


abstract: PURPOSE: @entity15127 has been shown to be effective in treating @entity1103 ( @entity1103 ). In the original Phase II/III trial, however, @entity1 with @entity63 were excluded. In this study, we treated @entity1 with @entity63 @entity1103 . METHODS: @entity63 was defined as a 30% increase in the area of the foveal avascular zone (FAZ) at 45 seconds on fundus @entity941 angiography. In addition, the @entity1 had diffuse foveal-involving @entity1103 with a central subfield thickness (CST) of >300  m on spectral-domain optical coherence tomography. Five intravitreal @entity15127 injections were given 6 weeks apart. The final study visit was 6 weeks after the fifth injection. The primary outcome was change in the size of FAZ. Secondary outcomes were change in best-corrected visual acuity (BCVA) and the change in CST. RESULTS: Thirty @entity1 were enrolled. Three were unable to complete the full course of treatment. Their outcomes were carried forward for the first part of this analysis. There was no statistically significant change in the mean size of the FAZ from baseline to the final visit. Subclassifying @entity1 as those with minimal/moderate @entity63 (16 @entity1 , FAZ area <1,000 pixels) and those with more severe @entity63 (14 @entity1 , FAZ area >1,000 pixels) also showed no statistically significant change in the mean area of the FAZ. On average, BCVA increased and CST decreased from baseline to the final visit, but these changes were not statistically significant. Using per protocol analysis on those @entity1 who completed the full course of treatment, the mean BCVA increased from 49.2 to 53.9 letters (P=0.046). CONCLUSION: In this study, intravitreal injection of @entity15127 did not significantly alter the size of the FAZ in @entity1 with varying degrees of @entity63 @entity1103 . There was, however, a significant improvement in mean BCVA in those who completed the treatment course.

title: Intravitreal XXXX for the treatment of @entity63 @entity1103 .

answer: @entity15127 :: (MESH:C495058,Chemical) :: ['pegaptanib']


abstract: BACKGROUND: In @entity1 with advanced-stage @entity1204 ( @entity1204 ), extended-field radiotherapy (efrt) is traditionally delivered by the 3-dimensional conformal (3d-crt) 4-field box technique. In recent years, the use of intensity-modulated radiotherapy (imrt) in gynecologic @entity5 has increased. We compared the delivery of efrt by the 3d-crt and contemporary imrt techniques. METHODS: After surgical staging and adjuvant chemotherapy in 38 @entity1204 @entity1 , efrt was delivered by either imrt or 3d-crt. Doses to the organs at risk, side effects, and outcomes were compared between the techniques. RESULTS: Of the 38 @entity1204 @entity1 , 33 were stage iiic, and 5 were stage ivb. In the imrt group, maximal doses to rectum, small intestine, and bladder were significantly higher, and mean dose to bladder was lower (p < 0.0001). Most acute gastrointestinal, genitourinary, and hematologic side effects were grade i or ii and were comparable between the groups. In long-term follow-up, only grade 1 @entity2335 at 3 months was statistically higher in the imrt @entity1 . No grade iii or iv @entity344 were observed. No statistically significant differences in overall and disease-free survival or recurrence rates were observed between the techniques. CONCLUSIONS: In advanced @entity1204 @entity1 , imrt is a safe and effective technique for delivering efrt to the pelvis and para-aortic region, and it is comparable to the 3d-crt 4-field box technique in both side effects and efficacy. For centres in which imrt is not readily available, 3d-crt is a valid alternative.

title: Para-aortic and pelvic extended-field radiotherapy for XXXX : dosimetric and toxicity comparison between the four-field box and intensity-modulated techniques.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'eca']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal or genitourinary toxicities']

answer: @entity5 :: (MESH:D009369,Disease) :: ['advanced-stage uterine cancer']


abstract: BACKGROUND: We estimated the relations of sociodemographic, organizational, disease, and treatment variables with the risk of @entity204 from @entity14 ( @entity14 ) in a Quebec population-based sample of @entity1 with locally advanced @entity14 (lacrc) who underwent @entity5 resection with curative intent. METHODS: Information from medical records and administrative databases was obtained for a random sample of 633 @entity1 surgically treated for stages ii-iii rectal and stage iii @entity694 and @entity5 registry in 1998 and 2003. We measured personal, disease, and clinical management characteristics, relative survival, and through multivariate modelling, relative excess rate (rer) of @entity204 . RESULTS: The relative 5- and 10-year survivals in this cohort were 67.7% [95% confidence interval (ci): 65.8% to 69.6%] and 61.2% (95% ci: 58.3% to 64.0%) respectively. Stage T4, stage N2, and emergency rather than elective surgery affected 18%, 24% and 10% of @entity1 respectively. Those disease progression characteristics each independently increased the rer of @entity204 by factors of 2 to almost 5. Grade, vascular invasion, and @entity5 location were also significantly associated with the rer for @entity204 . Receiving guideline-adherent treatment was associated with a 60% reduction in the rer for @entity204 (0.41; 95% ci: 0.28 to 0.61), an effect that was consistent across age groups. Clear margins (proximal-distal, radial) and clinical trial enrolment were each associated with a nonsignificant 50% reduction in the rer. Of @entity1 less than 70 years of age and 70 years of age and older, 81.3% and 42.0% respectively received guideline-adherent treatment. CONCLUSIONS: This study is the first Quebec population-based examination of @entity1 with lacrc and their management, outcomes, and outcome determinants. The results can help in planning @entity14 control strategies at a population level.

title: Characteristics affecting survival after locally advanced XXXX in Quebec.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['declared to the Quebec cancer', 'tumour']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['crc', 'colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: Targeting @entity1 @entity3138 with the monoclonal antibody (mAb) CB.219 reduces intestinal inflammation in a @entity1960 model where T cells carry @entity1 @entity3138 . Here, we asked whether this mAb has adverse effects on infection control. @entity19 expressing @entity1 @entity3138 on T cells (huCD2tg) were orally infected with @entity3204 ( @entity3204 and treated with the @entity1 @entity3138 -specific mAb CB.219 in a preventive setting. The intestinal @entity3204 loads in CB.219 treated @entity19 did not differ from the control group. Histologically, huCD2tg @entity19 showed moderate @entity32 that did not change with CB.219 treatment. In the ileum, CB.219 treatment reduced the protein levels of interferon-y, transforming growth factor b and @entity650 , whereas @entity8923 mRNA was slightly increased. The infiltration of neutrophils, macrophages, and T cells into the ileum was unaffected by CB.219 treatment. However, CB.219 treatment decreased the numbers of @entity3744 (+) regulatory T cells (Treg) in ileum and liver of huCD2tg @entity19 . This was confirmed in vitro using @entity1 peripheral blood mononuclear cells. Taken together, targeting @entity3138 (+) T cells by the @entity1 @entity3138 mAb CB.219 does not prevent beneficial immune reactions necessary for pathogen control. Further experiments will address gut specificity, underlying mechanisms, and general applicability of CB.219 treatment.

title: Preventive Anti-CD2 Treatment does not Impair Parasite Control in a XXXX Toxoplasmosis Model.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['ileal inflammation']

entities_list: @entity3204 :: ('5811', 'Species') :: ['T.) gondii', 'Toxoplasma', 'T. gondii']

answer: @entity19 :: (10090,Species) :: ['Murine']


abstract: BACKGROUND: The prevalence of @entity3885 is probably underestimated. Early detection and screening may alter the course and prognosis associated with @entity358 . We investigated the effectiveness of @entity358 function screening program and the agreement between the Global Initiative for @entity1030 (GOLD) and the lower limit of normal (LLN) standard for public screening in Xi'an China. METHODS: Pulmonary function testing was conducted on volunteers recruited from eight community centers in Xi'an, China between July and August 2012. @entity1 underwent three forced vital capacity (FVC) maneuvers. The maneuver with the best FEV1 was retained. @entity1 filled out a medical history survey before undergoing pulmonary function testing. @entity1 that self-reported @entity358 on the health survey were excluded from the analysis. RESULTS: A total of 803 volunteers participated in this study. And 722 @entity1 (93.8%) did not self-report chronic @entity358 and were analyzed. Of these @entity1 , 143 subjects (19.8%) were diagnosed by GOLD standard and 134 subjects (18.6%) had obstruction with LLN definition. GOLD definition can identify more asymptomatic subjects (19.1%) with respect to LLN. GOLD definition can detect more @entity3885 in elder subjects compared with young @entity1 , the difference is significant (P=0.0007). The overall agreement between the 2 methods was good: the kappa estimate was 0.822. The agreement in subjects aged 40-49, 50-59 and 60-69 years was good: the kappa estimate was 0.82, 0.936 and 0.907 respectively and the agreement in subjects aged 18-29 was inferior: the kappa estimate was only 0.555. CONCLUSIONS: Voluntary lung function screening program with GOLD standard may be a simple and effective approach to ensuring high yield detection of @entity3885 in subjects aged 40-69.

title: XXXX with GOLD standard: an effective and simple approach to detect @entity3885 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'Participants', 'people']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease', 'voluntary lung']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['lung obstruction']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['Chronic Obstructive Lung Disease']

answer: @entity358 :: (MESH:D008171,Disease) :: ['Voluntary pulmonary function screening']


abstract: BACKGROUND: The prevalence of @entity3885 is probably underestimated. Early detection and screening may alter the course and prognosis associated with @entity358 . We investigated the effectiveness of @entity358 function screening program and the agreement between the Global Initiative for @entity1030 (GOLD) and the lower limit of normal (LLN) standard for public screening in Xi'an China. METHODS: Pulmonary function testing was conducted on volunteers recruited from eight community centers in Xi'an, China between July and August 2012. @entity1 underwent three forced vital capacity (FVC) maneuvers. The maneuver with the best FEV1 was retained. @entity1 filled out a medical history survey before undergoing pulmonary function testing. @entity1 that self-reported @entity358 on the health survey were excluded from the analysis. RESULTS: A total of 803 volunteers participated in this study. And 722 @entity1 (93.8%) did not self-report chronic @entity358 and were analyzed. Of these @entity1 , 143 subjects (19.8%) were diagnosed by GOLD standard and 134 subjects (18.6%) had obstruction with LLN definition. GOLD definition can identify more asymptomatic subjects (19.1%) with respect to LLN. GOLD definition can detect more @entity3885 in elder subjects compared with young @entity1 , the difference is significant (P=0.0007). The overall agreement between the 2 methods was good: the kappa estimate was 0.822. The agreement in subjects aged 40-49, 50-59 and 60-69 years was good: the kappa estimate was 0.82, 0.936 and 0.907 respectively and the agreement in subjects aged 18-29 was inferior: the kappa estimate was only 0.555. CONCLUSIONS: Voluntary lung function screening program with GOLD standard may be a simple and effective approach to ensuring high yield detection of @entity3885 in subjects aged 40-69.

title: @entity358 with GOLD standard: an effective and simple approach to detect XXXX .

answer: @entity3885 :: (MESH:D008173,Disease) :: ['lung obstruction']


abstract: Twenty-two @entity1 with @entity15202 were surgically treated between 1967 and July 1975. Five (23%) were under 1 year of age (group I) and 17 (77%) were between 2 and 24 years (group II). All @entity1 exhibited severe @entity712 and electrocardiographi (ECG) evidence of @entity4346 ( @entity4346 ) with strain pattern. In group II, angina was present in three cases, @entity1163 and fatigue in two; the ECG indicated @entity4346 in 10 cases (59%) with strain pattern in five (29%). A bicuspid aortic valve was present in 77% (17/22) of the cases; 32% had other @entity299 . Aortic valvotomy was performed on cardiopulmonary bypass in 20 cases, and with deep @entity2332 and @entity1167 in two. Three @entity1 under 1 month of age with associated anomalies died (hospital mortality 14%). Intraoperative average peak left ventricular-aortic systolic pressure gradient decreased from 86 to 21 mmHg (P less than 0.001). Late clinical (in all cases) and haemodynamic (26%) follow-up showed severe @entity256 in two @entity1 of group II; one of them had a second operation, the other one died three and a half years postoperatively. Results assessed on the basis of symptoms, ECG changes, aortic valve function, and/or haemodynamic findings were fair in the two surviving @entity1 . Results in group II were excellent in three, satisfactory in seven, fair in four, and poor in two cases. In @entity1 , aortic valvotomy is a palliative procedure which carries a high risk. In the older age group, early and late results are more gratifying.

title: Surgical treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'infants']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis']

entities_list: @entity15202 :: ('MESH:C535576', 'Disease') :: ['congenital valvular aortic stenosis']

entities_list: @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy', 'LVH']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac anomalies']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['circulatory arrest']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

answer: @entity15202 :: (MESH:C535576,Disease) :: ['congenital valvular aortic stenosis']


abstract: UNASSIGNED: OBJECTIVE The @entity131 Foundation recommendation regarding the timing of surgical evacuation of @entity4282 and @entity3439 is to perform the procedure as soon as possible. Indeed, faster evacuation is associated with better outcome. However, to the authors' knowledge, no study has looked at where delays in intrahospital care occurred for @entity1 suffering from traumatic intracranial mass lesions. The goals of this study were as follows: 1) to characterize the performance of a Level 1 @entity130 center in terms of delays for @entity130 , 2) to review step by step where delays occurred in @entity1 care, and 3) to propose ways to improve performance. METHODS A retrospective review was conducted covering a 5-year period of all @entity130 . Demographic data, injury severity, @entity16 , and functional outcome data were collected. The time elapsed between @entity341 ( @entity341 ) arrival and CT imaging, between CT imaging and arrival at the operating room (OR), between @entity341 arrival and OR arrival, between OR arrival and skin incision, and between @entity341 arrival and skin incision were calculated. @entity1 were also subcategorized as either having immediate life-threatening emergencies (E0) or life-threatening emergencies (E1). The operative technique was also reviewed (standard craniotomy opening vs immediate bur hole decompression followed by craniotomy). RESULTS The study included 166 @entity1 . Of these, 58 (35%) were classified into the E0 group and 108 (64.2%) into the E1 group. The median @entity341 -to-CT delay was 54 minutes with no significant difference between the E0 and the E1 groups. The median CT-to-OR time delay was 57 minutes. The median delay for the E0 group was 39 minutes and that for the E1 group was 70 minutes (p = 0.002). The median delay from @entity341 to OR arrival for @entity1 with a CT scanning done at an outside hospital was 75 minutes. The median delay from @entity341 to OR arrival was 85 minutes for the E0 group and 127 minutes for the E1 group (p < 0.0001). The median delay from OR arrival to skin incision was 35 minutes (E0: median 27 minutes; E1: median 39 minutes; p < 0.0001). The median total time elapsed between @entity341 arrival and skin incision was 150 minutes (E0: median 131 minutes; E1: median 180 minutes). Overall, only 17% of @entity1 underwent immediate bur hole decompression, but the proportion climbed to 41% in the E0 group. A lower Glasgow @entity772 Scale score was associated with a shorter delay (p = 0.0004). CONCLUSIONS A long delay until surgery still exists for @entity1 requiring urgent mass lesion evacuation. Many factors contribute to this delay, including performing imaging and transfer to and preparation in the OR. Strategies can be implemented to reduce delays and improve the delivery of care.

title: Temporal delays in XXXX craniotomies.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['Brain Trauma']

entities_list: @entity4282 :: ('MESH:D046748', 'Disease') :: ['epidural hematomas']

entities_list: @entity3439 :: ('MESH:D006408', 'Disease') :: ['subdural hematomas']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological status']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['emergency trauma craniotomies', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: OBJECTIVE: The caudal zona incerta (cZI) is a promising, clinically beneficial target for deep brain stimulation (DBS) in @entity191 ( @entity191 ). To assess whether DBS of the cZI affects the rate of @entity935 terminal dysfunction, @entity191 @entity1 with and without DBS were followed prospectively with I FP-Cit single photon emission tomography from the first diagnosis and up to 8 years. METHODS: Six @entity1 underwent DBS of the cZI during the survey period. Twenty-two @entity191 @entity1 only on pharmacotherapy served as controls. I FP-Cit and clinical assessment were performed at baseline and after 1, 3 and 5 years in all @entity1 . Ten @entity1 also underwent a I FP-Cit after 8 years. Image data were evaluated semiquantitatively. Mixed-model analysis was used to assess the relative change in I FP-Cit uptake and comparison between surgically and conservatively treated @entity191 @entity1 . RESULTS: The relative decrease in I FP-Cit uptake was more pronounced in DBS-treated @entity1 than in controls in the more affected caudate (P=0.037) and putamen (P=0.013). The annual decrease rates were higher in the less affected than the more affected putamen, and were slightly greater in DBS-treated @entity1 (4.8%, 95%confidence interval: 8.5-2.2%) than in controls (4.0%, 95% confidence interval: 5.1-3.1%). CONCLUSION: This long-term prospective study confirms that the underlying @entity409 continues despite clinical improvement in @entity191 @entity1 with DBS of the cZI. A slightly faster rate of decrease in I FP-Cit uptake in these @entity1 compared with conservatively treated @entity191 @entity1 may reflect a more aggressive form of @entity191 .

title: Long-term XXXX transporter imaging in @entity191 treated with zona incerta stimulation.

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['dopaminergic dysfunction']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD']

answer: @entity935 :: (MESH:D004298,Chemical) :: ['dopamine']


abstract: OBJECTIVE: The caudal zona incerta (cZI) is a promising, clinically beneficial target for deep brain stimulation (DBS) in @entity191 ( @entity191 ). To assess whether DBS of the cZI affects the rate of @entity935 terminal dysfunction, @entity191 @entity1 with and without DBS were followed prospectively with I FP-Cit single photon emission tomography from the first diagnosis and up to 8 years. METHODS: Six @entity1 underwent DBS of the cZI during the survey period. Twenty-two @entity191 @entity1 only on pharmacotherapy served as controls. I FP-Cit and clinical assessment were performed at baseline and after 1, 3 and 5 years in all @entity1 . Ten @entity1 also underwent a I FP-Cit after 8 years. Image data were evaluated semiquantitatively. Mixed-model analysis was used to assess the relative change in I FP-Cit uptake and comparison between surgically and conservatively treated @entity191 @entity1 . RESULTS: The relative decrease in I FP-Cit uptake was more pronounced in DBS-treated @entity1 than in controls in the more affected caudate (P=0.037) and putamen (P=0.013). The annual decrease rates were higher in the less affected than the more affected putamen, and were slightly greater in DBS-treated @entity1 (4.8%, 95%confidence interval: 8.5-2.2%) than in controls (4.0%, 95% confidence interval: 5.1-3.1%). CONCLUSION: This long-term prospective study confirms that the underlying @entity409 continues despite clinical improvement in @entity191 @entity1 with DBS of the cZI. A slightly faster rate of decrease in I FP-Cit uptake in these @entity1 compared with conservatively treated @entity191 @entity1 may reflect a more aggressive form of @entity191 .

title: Long-term @entity935 transporter imaging in XXXX treated with zona incerta stimulation.

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: INTRODUCTION: Air pollution exposure has been linked to @entity73 , but little is known about biomarkers modifying this association. MicroRNAs (miRNAs) control gene expression and neuronal programming. miRNA levels vary due to single nucleotide polymorphisms (SNPs) in genes processing miRNAs from precursor molecules. OBJECTIVES: To investigate whether SNPs in miRNA-processing genes are associated with cognition and modify the relationship between black @entity505 (BC), marker of traffic-related pollution, and cognitive functions. METHODS: 533 Normative Aging Study @entity1 (mean  SD 72  7years) were tested  <=4 times (mean=1.7 times) using seven cognitive tests between 1995 and 2007. We tested interactions of 16 miRNA-related SNPs with 1-year average BC from a validated land-use-regression model. We used covariate-adjusted logistic regression for low ( <=25) Mini-Mental tate Examination (MMSE) and mixed-effect regression for a global cognitive score combining six other tests. RESULTS: Global cognition was negatively associated with the homozygous minor variant of @entity70793 @entity21178 (-0.42SD; 95%CI: (-0.71, -0.13)) relative to the major variant. BC-MMSE association was stronger in heterozygous carriers of @entity11778 @entity10405 (OR=1.99; 95%CI: (1.39, 2.85)) and minor variant carriers of @entity58556 @entity70794 (OR=1.34; 95%CI: (1.05, 1.7)), compared to their major variant. The BC-global-cognition association was stronger in heterozygous carriers of @entity58556 @entity60721 (-0.10SD; 95%CI: (-0.18, -0.02)), and @entity58556 @entity70795 (-0.09SD; 95%CI: (-0.17, -0.02)) relative to the major variant. Blood miRNA expression analyses showed associations only of @entity10405 @entity11778 with miR-9 and @entity26365 . CONCLUSIONS: Carriers of particular miRNA-processing SNPs had higher susceptibility to BC in BC-cognition associations, possibly due to influences on miRNA expression.

title: Long-term exposure to black XXXX , cognition and single nucleotide polymorphisms in microRNA processing genes in older @entity1 .

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired cognitive aging']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['carbon']


abstract: INTRODUCTION: Air pollution exposure has been linked to @entity73 , but little is known about biomarkers modifying this association. MicroRNAs (miRNAs) control gene expression and neuronal programming. miRNA levels vary due to single nucleotide polymorphisms (SNPs) in genes processing miRNAs from precursor molecules. OBJECTIVES: To investigate whether SNPs in miRNA-processing genes are associated with cognition and modify the relationship between black @entity505 (BC), marker of traffic-related pollution, and cognitive functions. METHODS: 533 Normative Aging Study @entity1 (mean  SD 72  7years) were tested  <=4 times (mean=1.7 times) using seven cognitive tests between 1995 and 2007. We tested interactions of 16 miRNA-related SNPs with 1-year average BC from a validated land-use-regression model. We used covariate-adjusted logistic regression for low ( <=25) Mini-Mental tate Examination (MMSE) and mixed-effect regression for a global cognitive score combining six other tests. RESULTS: Global cognition was negatively associated with the homozygous minor variant of @entity70793 @entity21178 (-0.42SD; 95%CI: (-0.71, -0.13)) relative to the major variant. BC-MMSE association was stronger in heterozygous carriers of @entity11778 @entity10405 (OR=1.99; 95%CI: (1.39, 2.85)) and minor variant carriers of @entity58556 @entity70794 (OR=1.34; 95%CI: (1.05, 1.7)), compared to their major variant. The BC-global-cognition association was stronger in heterozygous carriers of @entity58556 @entity60721 (-0.10SD; 95%CI: (-0.18, -0.02)), and @entity58556 @entity70795 (-0.09SD; 95%CI: (-0.17, -0.02)) relative to the major variant. Blood miRNA expression analyses showed associations only of @entity10405 @entity11778 with miR-9 and @entity26365 . CONCLUSIONS: Carriers of particular miRNA-processing SNPs had higher susceptibility to BC in BC-cognition associations, possibly due to influences on miRNA expression.

title: Long-term exposure to black @entity505 , cognition and single nucleotide polymorphisms in microRNA processing genes in older XXXX .

answer: @entity1 :: (9606,Species) :: ['men']


abstract: UNASSIGNED: Little is known about the role of endemic ticks as vectors for bacterial and protozoan pathogens for animals and @entity1 in Madagascar and their interaction in anthropogenic habitats where @entity1 , their livestock and native Malagasy species (vectors and hosts) come into more frequent contact than in natural forest ecosystems. The aims of the study were (1) to test whether habitat degradation is associated with increased @entity277 of tortoises by ticks and (2) to investigate whether ticks carried @entity743 , @entity12732 or @entity16452 species that might be pathogenic for @entity1 and livestock. We studied hard ticks of two endemic Malagasy tortoises, Astrochelys radiata and Pyxis arachnoides in March and April 2013 in southwest Madagascar. Two tortoise habitats were compared, the National Park of Tsimanampetsotsa and the adjacent degraded pasture and agricultural land at the end of the wet season. Ticks were screened for protozoan and bacterial pathogens via PCR on DNA isolated from ticks using genus-specific primers. Only one out of 42 A. radiata collected from both habitats had ticks. The low prevalence did not allow further analyses of the effect of habitat degradation. Forty-two P. arachnoides were found in the anthropogenic habitat and 36 individuals in the national park. @entity277 rates of P. arachnoides differed significantly between the two study sites. Tortoises inside the park had lower tick prevalence than outside (8 of 36 (22%) versus 32 of 42 individuals (76%)) and infected animals tended to have fewer ticks inside than outside the park. All ticks collected in both habitats were adults of the ixodid tick Amblyomma chabaudi, which is supposed to be a host-specific tick of P. arachnoides. Screening for @entity12732 sp. and @entity743 sp. was negative in all ticks. But all A. chabaudi ticks were infected with @entity16452 africae, known to cause spotted @entity221 in @entity1 . Thus, habitat degradation seems to be linked to higher @entity277 of tortoises with ticks with possible consequences for @entity1 and their livestock.

title: Tick (Amblyomma chabaudi) XXXX of endemic tortoises in southwest Madagascar and investigation of tick-borne pathogens.

entities_list: @entity277 :: ('MESH:D013984', 'Disease') :: ['infestation', 'Tick infestation']

entities_list: @entity16452 :: ('MESH:D012282', 'Disease') :: ['Rickettsia']

answer: @entity277 :: (MESH:D013984,Disease) :: ['infestation']


abstract: AIM OF STUDY: We examined variables associated with survival for @entity354 between 1996 and 2014. METHODS: Possible explanatory variables: birth weight, gestation, @entity299 (any or major), @entity8 (any or severe), primary @entity254 , leak, secondary oesophageal surgery, @entity825 , aortopexy, tracheostomy, gastrostomy, fundoplication, karyotype, neurological status. Variables were assessed with logistic regression and a new model assessed with Kaplan-Meier graphs. RESULTS: 104/120 (87%) babies survived. Median gestation 37weeks, 4 (3%) born before 28weeks. Mean birth weight 2.3 (SD 0.7) kg, 17 (14%) less than 1500g. Frequency (%) of explanatory variables: Major @entity299 21 (18%), any @entity299 48 (40%), @entity8 (8%), any @entity8 25 (21%), primary @entity254 105 (88%), @entity834 (13%), symptomatic @entity825 28 (23%), aortopexy 17 (14%), tracheostomy 12 (10%), @entity16 (6%), fundoplication 15 (13%), gastrostomy 30 (25%), secondary oesophageal surgery 8 (7%), abnormal karyotype 6 (5%). Multivariate analysis showed only renal (OR 0.04, 0.007 0.2) p=0.001, cardiac (OR 0.1, 0.002 0.6) p=0.01 and a primary @entity254 (OR 12.2, 1.8 81.6) p=0.01 (R2=0.48), or major cardiac (OR 0.04, 0.007 0.29) p=0.001 and severe @entity8 (OR 0.009, 0.001 0.12) p<0.001 alone were significant (R2=0.57). CONCLUSIONS: Survival is dependent on cardiac and @entity8 . Birth weight is not significant. We propose a new classification system: 1: neither severe renal nor major @entity299 , 2: either severe renal or major @entity299 , 3: severe renal and major @entity299 .

title: Statistical modelling of survival for babies with XXXX .

entities_list: @entity825 :: ('MESH:D055090', 'Disease') :: ['tracheomalacia']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal anomalies', 'renal anomaly', 'severe renal anomaly 10']

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leak 16']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological anomaly 7']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['oesophageal atresia']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac anomaly', 'cardiac anomalies']

answer: @entity354 :: (MESH:D005764,Disease) :: ['oesophageal atresia']


abstract: BACKGROUND: @entity384 ( @entity384 ) could be caused by mutations in more than 40 different genes. However, the pathogenic impact of specific mutations is in most cases unknown complicating the genetic counseling of affected families. Therefore, functional studies could contribute to distinguish pathogenic mutations and benign variants. Here, we present a novel heterozygous DES missense variant ( @entity70796 ; @entity70797 ) identified by next generation sequencing in a @entity384 @entity1 . DES encodes the cardiac intermediate filament protein @entity2283 , which has important functions in mechanical stabilization and linkage of the cell structures in cardiomyocytes. METHODS AND RESULTS: Cell transfection experiments and assembly assays of recombinant @entity2283 in combination with atomic force microscopy were used to investigate the impact of this novel DES variant on filament formation. @entity2283 - @entity70797 forms cytoplasmic aggregates indicating a severe intrinsic filament assembly defect of this mutant. Co-transfection experiments of wild-type and mutant @entity2283 conjugated to different fluorescence proteins revealed a dominant affect of this mutant on filament assembly. These experiments were complemented by apertureless scanning near-field optical microscopy. CONCLUSION: In vitro analysis demonstrated that @entity2283 - @entity70797 is unable to form regular filaments and accumulate instead within the cytoplasm. Therefore, we classified DES- @entity70797 as a likely pathogenic mutation. In conclusion, the functional characterization of DES- @entity70797 might have relevance for the genetic counseling of affected families with similar DES mutations and could contribute to distinguish pathogenic mutations from benign rare variants.

title: Functional characterization of the novel DES mutation XXXX associated with @entity384 reveals a dominant filament assembly defect.

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'Dilated cardiomyopathy']

answer: @entity70797 :: (p|SUB|L|136|P,ProteinMutation) :: ['p.L136P']


abstract: BACKGROUND: @entity384 ( @entity384 ) could be caused by mutations in more than 40 different genes. However, the pathogenic impact of specific mutations is in most cases unknown complicating the genetic counseling of affected families. Therefore, functional studies could contribute to distinguish pathogenic mutations and benign variants. Here, we present a novel heterozygous DES missense variant ( @entity70796 ; @entity70797 ) identified by next generation sequencing in a @entity384 @entity1 . DES encodes the cardiac intermediate filament protein @entity2283 , which has important functions in mechanical stabilization and linkage of the cell structures in cardiomyocytes. METHODS AND RESULTS: Cell transfection experiments and assembly assays of recombinant @entity2283 in combination with atomic force microscopy were used to investigate the impact of this novel DES variant on filament formation. @entity2283 - @entity70797 forms cytoplasmic aggregates indicating a severe intrinsic filament assembly defect of this mutant. Co-transfection experiments of wild-type and mutant @entity2283 conjugated to different fluorescence proteins revealed a dominant affect of this mutant on filament assembly. These experiments were complemented by apertureless scanning near-field optical microscopy. CONCLUSION: In vitro analysis demonstrated that @entity2283 - @entity70797 is unable to form regular filaments and accumulate instead within the cytoplasm. Therefore, we classified DES- @entity70797 as a likely pathogenic mutation. In conclusion, the functional characterization of DES- @entity70797 might have relevance for the genetic counseling of affected families with similar DES mutations and could contribute to distinguish pathogenic mutations from benign rare variants.

title: Functional characterization of the novel DES mutation @entity70797 associated with XXXX reveals a dominant filament assembly defect.

answer: @entity384 :: (MESH:D002311,Disease) :: ['dilated cardiomyopathy']


abstract: Diffuse @entity3794 was detected in 64 @entity1 (33 males and 31 females). The diagnosis was obtained in each case from the anamnesis, the clinical findings, the chest X-ray, disturbances of the respiratory function, and from the progress of the disease. The analysis of the material produced the following parameters ranging from indicative to typical: Dry cough was reported by 70% of the @entity1 as being trouble-some. Dyspnoea on exertion and at rest existed in 95%, and gradually increased during the progress of the disease in 76,5% of these cases. On auscultation ear-near crepitant rale was heard in 78% above the affected pulmonary parts. In 62 @entity1 (96,5%) the radiogram showed disseminated streaky-reticular as well as finely to coarsely mottled infiltrations. In more than half of these cases (53%) an increase in severity was observed during the follow-up. A predominantly restrictive disturbance of ventilation existed in 85,5%. Exclusive restriction was found in 65,5%. @entity519 was detected in 92% of our cases which was especially impressive when the arterial @entity26 pressure at rest was within the normal range. The electrocardiographic findings seemed to be less unequivocal. All in all it can be stated that in the synopsis of its manifestation DIPF can be positively identified by clinical means. This fact as well as therapeutical problems are discussed taking available publications into consideration, and respective conclusions are drawn for the clinician.

title: [A contribution to the symptomatology of diffuse XXXX (DIPF) (author's transl)].

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['Effort hypoxemia']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['interstitial pulmonary fibrosis']

answer: @entity3794 :: (MESH:D011658,Disease) :: ['interstitial pulmonary fibrosis']