abstract: UNASSIGNED: The aim of this study was to investigate the effect of two kinds of given diets on growth, on some carcass characteristics and on the major meat nutrients of local Algerian @entity742 breed. The investigated @entity742 breed called "Hamra" is one of the most famous breeds in Algeria. Among one 106 animals, 40 @entity742 were selected according to their age, similar livestock characteristics and body weight. The samples were divided into two equal groups: control and experimental @entity742 according to their live weight; 24.63        0.47 and 24.35        0.64  kg, respectively. Both groups were fed with two varieties of concentrate diets: @entity4336 diet based for the first group of control @entity742 (n   =   20) and @entity4336 substituted by @entity2247 (Variety Sa  da 183) for the second experimental group @entity742 (n   =   20). Both diets were supplemented with 200  g straw of @entity2247 /animal/ration. The chemical analysis of diets showed an elevated crude fibre content in the commercial concentrate. However, the experimental concentrate contained higher amounts of @entity460 . After 59  days of fattening, no significant difference was found among the two studied groups on the growth performance (p   >   0.05), showing the same final body weight. In contrast, a significant difference was found (p    <=   0.001) in relation to the cost of the given diet. This could affect the price of the produced meat. At 37.85        0.78  kg live weight, 10 @entity742 fed with experimental concentrate were slaughtered. The dressing percentage was 46.65  %, with 2.49  % of carcass shrink. Furthermore, an interesting percentage of total muscle was obtained (63.73  %) with a good carcass conformation scoring 9.56. Compared to other breed @entity742 , Hamra carcass could be considered as the most valuable one economically.

title: Partial substitution of XXXX for @entity4336 : effect on "Hamra" lamb growth performance, carcass and meat characteristics.

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity2247 :: (4513,Species) :: ['barley']


abstract: UNASSIGNED: The aim of this study was to investigate the effect of two kinds of given diets on growth, on some carcass characteristics and on the major meat nutrients of local Algerian @entity742 breed. The investigated @entity742 breed called "Hamra" is one of the most famous breeds in Algeria. Among one 106 animals, 40 @entity742 were selected according to their age, similar livestock characteristics and body weight. The samples were divided into two equal groups: control and experimental @entity742 according to their live weight; 24.63        0.47 and 24.35        0.64  kg, respectively. Both groups were fed with two varieties of concentrate diets: @entity4336 diet based for the first group of control @entity742 (n   =   20) and @entity4336 substituted by @entity2247 (Variety Sa  da 183) for the second experimental group @entity742 (n   =   20). Both diets were supplemented with 200  g straw of @entity2247 /animal/ration. The chemical analysis of diets showed an elevated crude fibre content in the commercial concentrate. However, the experimental concentrate contained higher amounts of @entity460 . After 59  days of fattening, no significant difference was found among the two studied groups on the growth performance (p   >   0.05), showing the same final body weight. In contrast, a significant difference was found (p    <=   0.001) in relation to the cost of the given diet. This could affect the price of the produced meat. At 37.85        0.78  kg live weight, 10 @entity742 fed with experimental concentrate were slaughtered. The dressing percentage was 46.65  %, with 2.49  % of carcass shrink. Furthermore, an interesting percentage of total muscle was obtained (63.73  %) with a good carcass conformation scoring 9.56. Compared to other breed @entity742 , Hamra carcass could be considered as the most valuable one economically.

title: Partial substitution of @entity2247 for XXXX : effect on "Hamra" lamb growth performance, carcass and meat characteristics.

answer: @entity4336 :: (381124,Species) :: ['corn']


abstract: BACKGROUND: @entity9933 ( @entity9933 ) is a serious and rare condition that often presents a complex surgical challenge. We reviewed the evolution of surgical approaches to the management of @entity9933 at a single institution. METHODS: We conducted a retrospective clinical review of all @entity1 who underwent surgical repair of @entity9933 at our institution. From January 1992 to January 2014, a total of 30 @entity1 (median age 92 days; range 3 days-1.7 years) underwent surgery for @entity9933 at our institution. Techniques included slide tracheoplasty (n = 16), tracheal resection (n = 10), pericardial patch tracheoplasty (n = 3), and costal cartilage tracheoplasty (n = 1). Twenty-two (73%) @entity1 had associated @entity154 , including 18 (60%) with @entity358 sling. Five (17%) @entity1 had associated @entity358 . All procedures were performed via a median sternotomy with cardiopulmonary bypass. RESULTS: Median postoperative length of stay was 25 days (range, 5-431 days). Late airway reintervention was required in seven (26%), including two (15%) @entity1 after slide tracheoplasty, two (22%) posttracheal resection, and two (100%) post pericardial patch tracheoplasty. The one @entity1 who underwent costal cartilage tracheoplasty required multiple reinterventions. Overall mortality was 13% (n = 4), two @entity204 occurred post slide tracheoplasty, one @entity204 occurred after tracheal resection, and one after pericardial patch tracheoplasty, respectively. CONCLUSION: Slide tracheoplasty is the procedure of choice for repair of @entity9933 , while tracheal resection is a viable option for @entity1 with discreet, short-segment @entity850 .

title: Evolution of Surgical Approaches in the Management of XXXX : Single-Center Experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'infants']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['intracardiac or great vessel anomalies']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['left pulmonary artery', 'single lung malformation']

entities_list: @entity9933 :: ('MESH:C536975', 'Disease') :: ['CTS', 'Congenital tracheal stenosis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

answer: @entity9933 :: (MESH:C536975,Disease) :: ['Congenital Tracheal Stenosis']


abstract: INTRODUCTION: @entity1152 ( @entity1152 ) is the interruption of the continuity of the esophagus, with or without persistent communication with the @entity825 . Recent advances in surgical techniques have made possible correction with minimally invasive surgery (MIS). OBJECTIVE: To evaluate the management of thoracoscopic technique in the treatment of @entity1152 . @entity1 AND METHOD: Retrospective analysis of medical records in two centers was carried out between 2007 and 2012. Variables such as gestational age, gender, weight, type of @entity1152 , @entity260 were recorded. RESULTS: Twenty @entity1 , 15 of them with type III @entity1152 , 4 with type I and one unclassifiable, were part of the study. 13 @entity1 underwent ligation, cut of @entity4501 and end to end @entity254 . Two underwent laparoscopic gastrostomy and @entity292 ligation. One @entity1 required conversion and underwent esophagostomy plus gastrostomy. 4 @entity1 without @entity292 required laparoscopic gastrostomy and aspiration of the proximal esophagus to be able to perform esophageal @entity254 . In the postoperative period, pleural drainage and a transanastomotic feeding tube were installed. Seven @entity1 required esophageal dilations and 4 @entity1 developed @entity850 due to reflux. Two had recurrent @entity292 , one with spontaneous resolution and another with endoscopic resolution. Three @entity1 died: two of them due to pathologies not related to surgery and one as a result of limitation of therapeutic effort after @entity292 patency. DISCUSSION: @entity1152 repair with MIS is a safe and effective option with excellent exposure and visualization of anatomic landmarks and little associated morbidity.

title: [Thoracoscopic repair of @entity1152 with and without XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS', 'patient']

entities_list: @entity4501 :: ('MESH:D014138', 'Disease') :: ['tracheoesophageal fistula']

entities_list: @entity1152 :: ('MESH:D004933', 'Disease') :: ['Esophageal atresia', 'esophageal atresia', 'EA']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['malformations, surgery and postoperative complications']

answer: @entity4501 :: (MESH:D014138,Disease) :: ['tracheoesophageal fistula']


abstract: INTRODUCTION: @entity1152 ( @entity1152 ) is the interruption of the continuity of the esophagus, with or without persistent communication with the @entity825 . Recent advances in surgical techniques have made possible correction with minimally invasive surgery (MIS). OBJECTIVE: To evaluate the management of thoracoscopic technique in the treatment of @entity1152 . @entity1 AND METHOD: Retrospective analysis of medical records in two centers was carried out between 2007 and 2012. Variables such as gestational age, gender, weight, type of @entity1152 , @entity260 were recorded. RESULTS: Twenty @entity1 , 15 of them with type III @entity1152 , 4 with type I and one unclassifiable, were part of the study. 13 @entity1 underwent ligation, cut of @entity4501 and end to end @entity254 . Two underwent laparoscopic gastrostomy and @entity292 ligation. One @entity1 required conversion and underwent esophagostomy plus gastrostomy. 4 @entity1 without @entity292 required laparoscopic gastrostomy and aspiration of the proximal esophagus to be able to perform esophageal @entity254 . In the postoperative period, pleural drainage and a transanastomotic feeding tube were installed. Seven @entity1 required esophageal dilations and 4 @entity1 developed @entity850 due to reflux. Two had recurrent @entity292 , one with spontaneous resolution and another with endoscopic resolution. Three @entity1 died: two of them due to pathologies not related to surgery and one as a result of limitation of therapeutic effort after @entity292 patency. DISCUSSION: @entity1152 repair with MIS is a safe and effective option with excellent exposure and visualization of anatomic landmarks and little associated morbidity.

title: [Thoracoscopic repair of XXXX with and without @entity4501 ].

answer: @entity1152 :: (MESH:D004933,Disease) :: ['esophageal atresia']


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: @entity5 cases numbers are increasing worldwide positioning this disease as the second cause of mortality for both sexes. Medicinal plants have been used in the fight against @entity5 as the basis for drug discovery and nowadays more than 70% of anticancer drugs have a natural origin. Mexico is regarded for its cultural and biological diversity, which is reflected in the vast traditional knowledge of herbal remedies. In this review we examined herbal remedies employed in @entity14 ( @entity14 ). AIM OF THE STUDY: The goal of this work was to gather scientific reports of plants used in Mexican traditional medicine for @entity14 treatment. MATERIALS AND METHODS: We performed a search on scientific literature databases using as keywords: " @entity694 ", " @entity356 ", " @entity137 ", studies "in vitro and in vivo", in combination with "Mexican medicinal plants" or "Mexican herbal remedies". The selection criteria of cytotoxic activity for extracts or pure compounds was based on the National @entity5 Institute of USA recommendations of effective dose 50 (ED50) of <=20 g/mL and <=4 g/mL, respectively. RESULTS: In this review we report 25 botanic families and 39 species of plants used for the treatment of @entity694 in Mexico with evidence in studies in vitro and in vivo. CONCLUSIONS: Medicinal plants are still a great source of novel chemical structures with antineoplastic potential as it is proven in this work. The selection criteria and activity was narrowed for methodological purposes, nevertheless, drug discovery of natural origin continues to be a highly attractive R_D strategy.

title: Medicinal plants used in Mexican traditional medicine for the treatment of XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer treatment']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: INTRODUCTION: Primary @entity5 of lung (PSGTTL) are rare intra-thoracic malignant @entity5 . Their description in literature is largely limited to a few case series/case reports. We herewith present our surgical experience of and review its clinical presentation, management options and survival outcomes. METHODS: This retrospective analysis of prospectively maintained computerized data-base of @entity1 was conducted in a tertiary teaching oncology centre in North India. The case records of all the @entity1 who underwent surgery for PSGTTL were reviewed. Details concerning the clinical presentation, preoperative therapy, operative procedure, histopathological examination, @entity260 and outcome were retrieved from the case records. RESULTS: There were seven @entity1 who underwent surgery for PSGTTL during the period from January 2012 to December 2014. Hemoptysis (n = 6, 85.7%) and dyspnoea (n = 6, 85.7%) were common presenting clinical features. Fiber-optic bronchoscopy revealed endobronchial growth in all @entity1 - five @entity1 had growth in left main bronchus while one each had growth in right main bronchus and right intermediate bronchus. Biopsy confirmed adenoid cystic carcinoma in 4 (57.1%) and muco-epidermoid carcinoma in 3 (42.9%) @entity1 . All but one had R'0' resection - pneumonectomy in five and bilobectomy in one @entity1 ; one @entity1 was found to be unresectable in view of dense adhesions between lung and heart. Median pathological tumor size was 3.5 cm; none of the @entity1 was found to have metastatic spread to lymph nodes. Overall, six @entity1 are alive after a median follow up of 5 months (range 1-30). CONCLUSION: Radical surgery to achieve R'0' resection is the main stay of treatment of PSGTTL to achieve prolonged survival.

title: Surgical experience of primary XXXX of lung: A case series.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['salivary gland type tumors', 'neoplasm']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

answer: @entity5 :: (MESH:D009369,Disease) :: ['salivary gland tumors']


abstract: @entity2696 are a common form of @entity1462 of the lymphatic vessels, mainly in the head and neck region. Most cases are progressive evolution and require a multidisciplinary approach. Currently, the first therapeutic option is sclerotherapy, leaving surgery for the treatment of remaining lesions. OBJECTIVE: To present a case of @entity17461 (LM) treated with sclerotherapy, surgery and orthodontics in a 15-year follow up. CASE REPORT: A one-year-old female @entity1 who consulted health professionals due to a progressive volume increase of the soft parts of her right cheek. The imaging study confirmed the diagnosis of @entity600 . It was managed with @entity1012 sclerotherapy and @entity1732 . At 2 years of age, the @entity1 response was considered adequate; an intralesional submandibular surgical excision was then performed, with partial resection of the lesion. The biopsy confirmed the diagnosis of microcystic LM. Six months after, a re-resection was planned using the same approach and removing the remaining lesion, with favorable development until the age of 9 years when the @entity1 required surgery and orthodontic management due to intraoral recurrence. No major developments until the age of 13 when a new orthodontic surgery and handling are planned to perform right oral commissure suspension. CONCLUSION: LM management by sclerotherapy, surgery, and orthodontics has shown the advantages of a multidisciplinary long-term treatment in this case.

title: [Mixed XXXX : Case report].

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['microcystic lymphatic malformation']

entities_list: @entity2696 :: ('MESH:D008202', 'Disease') :: ['Lymphangiomas']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['Bleomycin']

entities_list: @entity1462 :: ('MESH:D054079', 'Disease') :: ['vascular malformation']

entities_list: @entity17461 :: ('MESH:D044148', 'Disease') :: ['facial lymphatic malformation']

answer: @entity17461 :: (MESH:D044148,Disease) :: ['facial lymphatic malformation']


abstract: BACKGROUND: The objective of this meta-analysis was to evaluate the risk of @entity417 in @entity1 who received renin-angiotensin system (RAS) inhibitors. METHODS: A literature search was performed using MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews from inception through November, 2014. Studies that reported relative risks, odd ratios or hazard ratios comparing the @entity417 risk in @entity1 who received angiotensin-converting-enzyme inhibitors (ACEIs) or angiotensin II receptor blockers (ARBs) vs. those who did not were included. We performed the prespecified sensitivity analysis including only only studies with confounder adjusted analysis. Pooled risk ratios (RRs) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse variance method. RESULTS: Seven studies (2 cohort and 5 cross-sectional studies) with 29   061 @entity1 were included in the analysis to assess the risk of @entity417 and the RAS inhibitors use. The pooled RR of @entity417 in @entity1 receiving ACEIs was 1.56 (95% CI, 1.40-1.73, I(2)   =   17%). When meta-analysis was limited only to studies with confounder adjusted analysis, the pooled RR of @entity417 in @entity1 using ACEIs was 1.57 (95% CI, 1.43-1.73, I(2)   =   0%) The pooled RR of @entity417 in @entity1 receiving ARBs was 1.60 (95% CI, 1.27-2.00, I(2)   =   39%). The meta-analysis of studies with confounder adjusted analysis demonstrated the pooled RR of @entity417 in @entity1 using ARBs of 1.59 (95% CI, 1.38-1.83, I(2)   =   0%). CONCLUSIONS: Our meta-analysis demonstrates an association between @entity417 and the use of RAS inhibitors. Hematological parameters should be monitored in @entity1 treated with RAS inhibitors.

title: XXXX : a systematic review and meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity417 :: (MESH:D000740,Disease) :: ['Renin-angiotensin system inhibitors linked to anemia']


abstract: OBJECTIVE The Dynesys, a @entity1344 ( @entity1344 ) system, was introduced to overcome the drawbacks of fusion procedures. Nevertheless, the theoretical advantages of @entity1344 over fusion have not been clearly confirmed. The aim of this study was to compare clinical and radiological outcomes of @entity1 who underwent @entity1344 using the Dynesys system with those who underwent @entity2649 ( @entity2649 ). METHODS The authors searched PubMed, Embase, Web of Science, and the Cochrane Database. Studies that reported outcomes of @entity1 who underwent @entity1344 or @entity2649 for the treatment of @entity179 were included. The primary efficacy end points were perioperative outcomes. The secondary efficacy end points were changes in the @entity615 visual analog scale (VAS) scores and in range of motion (ROM) at the treated and adjacent segments. A meta-analysis was performed to calculate @entity353 ( @entity353 ), 95% confidence intervals, Q statistics, and I(2) values. Forest plots were constructed for each analysis group. RESULTS Of the 274 retrieved articles, 7 (which involved 506 @entity1 [Dynesys, 250; @entity2649 , 256]) met the inclusion criteria. The Dynesys group showed a competitive advantage in mean surgery duration (20.73 minutes, 95% CI 8.76-32.70 minutes), @entity190 (81.87 ml, 95% CI 45.11-118.63 ml), and length of hospital stay (1.32 days, 95% CI 0.23-2.41 days). Both the Dynesys and @entity2649 groups experienced improved ODI and VAS scores after 2 years of follow-up. Regarding the ODI and VAS scores, no statistically significant difference was noted according to surgical procedure (ODI: WMD 0.12, 95% CI -3.48 to 3.72; back @entity158 VAS score: WMD -0.15; 95% CI -0.56 to 0.26; leg @entity158 VAS score: WMD -0.07; 95% CI -0.47 to 0.32). The mean ROM at the adjacent segment increased in both groups, and there was no substantial difference between them (WMD 1.13; 95% CI -0.33 to 2.59). Although the United States is the biggest market for Dynesys, no eligible study from the United States was found, and 4 of 8 enrolled studies were performed in China. The results must be interpreted with caution because of publication bias. During Dynesys implantation, surgeons have to decide the length of the spacer and cord pretension. These values are debatable and can vary according to the surgeon's experience and the @entity1 's condition. Differences between the surgical procedures were not considered in this study. CONCLUSIONS Fusion still remains the method of choice for @entity528 and gross instability. However, @entity179 with or without Grade I spondylolisthesis, particularly in @entity1 who require a quicker recovery, will likely constitute the main indication for @entity1344 using the Dynesys system.

title: Dynamic stabilization using the Dynesys system versus @entity2649 for the treatment of XXXX : a clinical and radiological outcomes-based meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['WMDs', 'weighted mean differences']

entities_list: @entity2649 :: ('MESH:C563613', 'Disease') :: ['posterior lumbar interbody fusion', 'PLIF']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['Oswestry Disability Index (ODI) and back and leg pain']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative lumbar spinal disease', 'spinal degenerative disease']

entities_list: @entity1344 :: ('MESH:D043171', 'Disease') :: ['pedicle-based dynamic stabilization', 'PDS']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['advanced degeneration']

answer: @entity179 :: (MESH:D019636,Disease) :: ['degenerative lumbar spinal disease']


abstract: OBJECTIVE The Dynesys, a @entity1344 ( @entity1344 ) system, was introduced to overcome the drawbacks of fusion procedures. Nevertheless, the theoretical advantages of @entity1344 over fusion have not been clearly confirmed. The aim of this study was to compare clinical and radiological outcomes of @entity1 who underwent @entity1344 using the Dynesys system with those who underwent @entity2649 ( @entity2649 ). METHODS The authors searched PubMed, Embase, Web of Science, and the Cochrane Database. Studies that reported outcomes of @entity1 who underwent @entity1344 or @entity2649 for the treatment of @entity179 were included. The primary efficacy end points were perioperative outcomes. The secondary efficacy end points were changes in the @entity615 visual analog scale (VAS) scores and in range of motion (ROM) at the treated and adjacent segments. A meta-analysis was performed to calculate @entity353 ( @entity353 ), 95% confidence intervals, Q statistics, and I(2) values. Forest plots were constructed for each analysis group. RESULTS Of the 274 retrieved articles, 7 (which involved 506 @entity1 [Dynesys, 250; @entity2649 , 256]) met the inclusion criteria. The Dynesys group showed a competitive advantage in mean surgery duration (20.73 minutes, 95% CI 8.76-32.70 minutes), @entity190 (81.87 ml, 95% CI 45.11-118.63 ml), and length of hospital stay (1.32 days, 95% CI 0.23-2.41 days). Both the Dynesys and @entity2649 groups experienced improved ODI and VAS scores after 2 years of follow-up. Regarding the ODI and VAS scores, no statistically significant difference was noted according to surgical procedure (ODI: WMD 0.12, 95% CI -3.48 to 3.72; back @entity158 VAS score: WMD -0.15; 95% CI -0.56 to 0.26; leg @entity158 VAS score: WMD -0.07; 95% CI -0.47 to 0.32). The mean ROM at the adjacent segment increased in both groups, and there was no substantial difference between them (WMD 1.13; 95% CI -0.33 to 2.59). Although the United States is the biggest market for Dynesys, no eligible study from the United States was found, and 4 of 8 enrolled studies were performed in China. The results must be interpreted with caution because of publication bias. During Dynesys implantation, surgeons have to decide the length of the spacer and cord pretension. These values are debatable and can vary according to the surgeon's experience and the @entity1 's condition. Differences between the surgical procedures were not considered in this study. CONCLUSIONS Fusion still remains the method of choice for @entity528 and gross instability. However, @entity179 with or without Grade I spondylolisthesis, particularly in @entity1 who require a quicker recovery, will likely constitute the main indication for @entity1344 using the Dynesys system.

title: Dynamic stabilization using the Dynesys system versus XXXX for the treatment of @entity179 : a clinical and radiological outcomes-based meta-analysis.

answer: @entity2649 :: (MESH:C563613,Disease) :: ['posterior lumbar interbody fusion']


abstract: BACKGROUND: Type 2 @entity6 is a major challenge for Canadian public health authorities, and regular physical activity is a key factor in the management of this disease. Given that fewer than half of @entity1 with @entity164 2 @entity6 in Canada are sufficiently active to meet the recommendations, effective programs targeting the adoption of regular physical activity (PA) are in demand for this population. Many researchers argue that Web-based, tailored interventions targeting PA are a promising and effective avenue for sedentary populations like Canadians with @entity164 2 @entity6 , but few have described the detailed development of this kind of intervention. OBJECTIVE: This paper aims to describe the systematic development of the Web-based, tailored intervention, Diab  te en Forme, promoting regular aerobic PA among adult Canadian francophones with @entity164 2 @entity6 . This paper can be used as a reference for health professionals interested in developing similar interventions. We also explored the integration of theoretical components derived from the I-Change Model, Self-Determination Theory, and Motivational Interviewing, which is a potential path for enhancing the effectiveness of tailored interventions on PA adoption and maintenance. METHODS: The intervention development was based on the program-planning model for tailored interventions of Kreuter et al. An additional step was added to the model to evaluate the intervention's usability prior to the implementation phase. An 8-week intervention was developed. The key components of the intervention include a self-monitoring tool for PA behavior, a weekly action planning tool, and eight tailored motivational sessions based on attitude, self-efficacy, intention, @entity164 of motivation, PA behavior, and other constructs and techniques. Usability evaluation, a step added to the program-planning model, helped to make several improvements to the intervention prior to the implementation phase. RESULTS: The intervention development cost was about CDN  59,700 and took approximately 54 full-time weeks. The intervention officially started on September 29, 2014. Out of 2300 potential @entity1 targeted for the tailored intervention, approximately 530 @entity1 visited the website, 170 @entity1 completed the registration process, and 83 corresponded to the selection criteria and were enrolled in the intervention. CONCLUSIONS: Usability evaluation is an essential step in the development of a Web-based tailored intervention in order to make pre-implementation improvements. The effectiveness and relevance of the theoretical framework used for the intervention will be analyzed following the process and impact evaluation. Implications for future research are discussed.

title: Development of a fully automated, web-based, tailored intervention promoting regular physical activity among insufficiently active adults with XXXX 2 @entity6 : integrating the I-change model, self-determination theory, and motivational interviewing components.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'people']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: BACKGROUND: Type 2 @entity6 is a major challenge for Canadian public health authorities, and regular physical activity is a key factor in the management of this disease. Given that fewer than half of @entity1 with @entity164 2 @entity6 in Canada are sufficiently active to meet the recommendations, effective programs targeting the adoption of regular physical activity (PA) are in demand for this population. Many researchers argue that Web-based, tailored interventions targeting PA are a promising and effective avenue for sedentary populations like Canadians with @entity164 2 @entity6 , but few have described the detailed development of this kind of intervention. OBJECTIVE: This paper aims to describe the systematic development of the Web-based, tailored intervention, Diab  te en Forme, promoting regular aerobic PA among adult Canadian francophones with @entity164 2 @entity6 . This paper can be used as a reference for health professionals interested in developing similar interventions. We also explored the integration of theoretical components derived from the I-Change Model, Self-Determination Theory, and Motivational Interviewing, which is a potential path for enhancing the effectiveness of tailored interventions on PA adoption and maintenance. METHODS: The intervention development was based on the program-planning model for tailored interventions of Kreuter et al. An additional step was added to the model to evaluate the intervention's usability prior to the implementation phase. An 8-week intervention was developed. The key components of the intervention include a self-monitoring tool for PA behavior, a weekly action planning tool, and eight tailored motivational sessions based on attitude, self-efficacy, intention, @entity164 of motivation, PA behavior, and other constructs and techniques. Usability evaluation, a step added to the program-planning model, helped to make several improvements to the intervention prior to the implementation phase. RESULTS: The intervention development cost was about CDN  59,700 and took approximately 54 full-time weeks. The intervention officially started on September 29, 2014. Out of 2300 potential @entity1 targeted for the tailored intervention, approximately 530 @entity1 visited the website, 170 @entity1 completed the registration process, and 83 corresponded to the selection criteria and were enrolled in the intervention. CONCLUSIONS: Usability evaluation is an essential step in the development of a Web-based tailored intervention in order to make pre-implementation improvements. The effectiveness and relevance of the theoretical framework used for the intervention will be analyzed following the process and impact evaluation. Implications for future research are discussed.

title: Development of a fully automated, web-based, tailored intervention promoting regular physical activity among insufficiently active adults with @entity164 2 XXXX : integrating the I-change model, self-determination theory, and motivational interviewing components.

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: OBJECTIVE: To examine the effect of exercise therapy on the walking ability of individuals with @entity626 . DATA SOURCES: @entity922 ( @entity922 ) were identified by searching through PubMed, Cochrane Central Register of Controlled Trials, Physiotherapy Evidence Database, and Cumulative Index to Nursing and Allied Health Literature. All literature published to October 2014 were included in the search. REVIEW METHODS: Data were collected from @entity922 that compared the effects of exercise therapy on walking ability with the effects of no intervention or psychoeducational intervention in @entity1 with @entity626 . The outcome data on the total distance walked (6-minute walk test); the amount of time spent walking (the time to walk arbitrary distances); and gait velocity were obtained and analysed. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) were calculated. RESULTS: Twenty-eight @entity922 were identified. Meta-analysis provided very-low-quality evidence that exercise therapy increased the total distance walked in the 6-minute walk test, in comparison with the effects of the control interventions ( @entity7126 = 0.44, 95% CI 0.27 to 0.60). Meta-analysis also provided low- or moderate-quality evidence that the amount of time spent walking and gait velocity were improved more by exercise therapy than by the control interventions (the amount of time spent walking: @entity7126 = -0.50, 95% CI -0.70 to -0.30; gait velocity: @entity7126 = 1.78, 95% CI 0.98 to 2.58). CONCLUSION: In individuals with @entity626 , exercise therapy can improve the amount of time spent walking, gait velocity, and maybe the total distance walked.

title: Effects of exercise therapy on walking ability in individuals with XXXX : A systematic review and meta-analysis of randomised controlled trials.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['Randomised clinical trials', 'RCTs']

answer: @entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']


abstract: UNASSIGNED: Reduced @entity7309 ( @entity7309 ) levels and higher soluble fms-like @entity669 kinase (sFlt-1) levels in mothers during pregnancy may have persistent effects on vascular structures in their offspring. We examined whether angiogenic factors during pregnancy also affect childhood retinal microvasculature in a population-based prospective cohort study among 3505 mothers and their @entity1 . We measured maternal @entity7309 and sFlt-1 in the first and second trimester of pregnancy. At the age of 6, we measured childhood retinal arteriolar and venular calibers from digitized retinal photographs. We performed multiple linear regression models, taking maternal and childhood sociodemographic and lifestyle-related characteristics, birth characteristics, and childhood current body mass index and blood pressure into account. We observed that first trimester maternal @entity7309 and sFlt-1 levels were not associated with childhood retinal arteriolar caliber. Lower second trimester maternal @entity7309 levels, but not sFlt-1 levels, were associated with narrower childhood retinal arteriolar caliber (difference: -0.09 SD score [95% confidence interval, -0.16 to 0.01], per SD score decrease in @entity7309 ). This association was not explained by maternal and childhood sociodemographic and lifestyle-related characteristics, birth characteristics, or childhood current body mass index and blood pressure. Maternal @entity7309 and sFlt-1 levels in the first or second trimester were not associated with childhood retinal venular caliber. Our results suggest that lower maternal second trimester @entity7309 levels affect the microvascular development in the offspring, leading to narrower retinal arteriolar caliber in childhood. Further studies are needed to confirm these findings and to explore the underlying mechanisms and long-term cardiovascular consequences.

title: Influence of Maternal Angiogenic Factors During Pregnancy on Microvascular Structure in School-Age XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

entities_list: @entity7309 :: ('5228', 'Gene') :: ['PlGF', 'placental growth factor']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: A large-scale trial of methods of early detection of @entity0 has been started in Great Britain. This non-randomized trial aims to compare @entity0 mortality over several years among @entity1 aged 45-64 years who have been offered various services for early detection of @entity0 . A quantitative assessment of benefits (lives saved) and costs (unnecessary surgery, radiation hazard, and use of health service resources) will be made. A total population of over 250,000 @entity1 living in eight districts is being studied in the trial. In two districts the @entity1 are invited for annual screening by clinical examination and mammography; in two other districts they are invited to teaching sessions to learn breast self-examination. The remaining four districts, with a population of 120,000 @entity1 , serve as a comparison and have no extra services beyond conventional diagnostic facilities. A register of all breast histology among these @entity1 has been set up, and, for those who have @entity0 , details of diagnosis, treatment and annual follow-up are recorded. All changes to the population are noted, and the cause of all @entity204 recorded. Factors influencing acceptance of early detection programmes, and the sensitivity and specificity of different screening methods are being studied. Mortality rates from @entity0 in the three types of population (screening, self-examination and comparison groups) will be the main index of effectiveness, but other questions relative to evaluation of screening, such as lead-time natural history of pre-invasive @entity5 , and identification of high-risk @entity1 , will also be assessed.

title: [Evaluation of early detection of XXXX in Great Britain (author's transl)].

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: OBJECTIVE: We report our experience in providing palliative radiotherapy (RT) to @entity1 with @entity135 ( @entity135 ). Our hypofractionated regimen, "0-7-21", treats @entity1 with 24   Gy in three fractions. METHODS: @entity1 , disease and response data were retrieved for candidates of 0-7-21 from 2005 to 2012. Primary end points included symptom and @entity5 size responses to RT based on response evaluation criteria in solid @entity5 (RECIST) guidelines. Secondary end points included progression-free survival (PFS) within the irradiated field, @entity1349 ( @entity1349 ) and symptomatic PFS (SPFS), calculated using Kaplan-Meier method and adverse events. Cox proportional hazards regression and logistic regression were used to investigate for prognostic factors. RESULTS: A total of 110 @entity1 were included. Among the @entity1 , 40% and 31% had complete response for symptoms and @entity5 size, respectively; 42% and 50% had partial response for symptoms and @entity5 size, respectively; and 15% had stability of symptoms and @entity5 size. Median 6-month @entity1349 was 51%, and PFS within the irradiated field was 39%. Planning target volume was predictive of @entity1349 (p   <   0.001), PFS (p   <   0.001) and SPFS (p   <   0.005), while higher TNM stage was associated with poorer @entity5 response (p   =   0.02). CONCLUSION: 0-7-21 is an effective and well-tolerated palliative RT regimen for @entity1 with HNC. There was excellent symptom and local control with acceptable @entity137 profile in these @entity1 . ADVANCES IN KNOWLEDGE: This is the first study to describe the outcomes of 0-7-21 in treating advanced @entity135 . The positive results suggest that 0-7-21 provides excellent palliation with minimal @entity137 , with significantly less on-treatment time than current published palliative RT regimen.

title: 0-7-21 hypofractionated palliative radiotherapy: an effective treatment for advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancers', 'HNCs']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck cancers']


abstract: BACKGROUND: Recombinant bone morphogenetic protein two (rhBMP2) has been utilised for a variety of clinical applications in orthopaedic surgery and dental procedures. Despite its widespread use, concerns have been raised regarding its short half-life and transient bioactivity in vivo. Recent investigation aimed at developing rhBMP2 synthesized from a shorter polypeptide chain (108 @entity3534 ) has been undertaken. METHODS: The osteopromotive properties of @entity1841 were investigated on cell behaviour. Five concentrations of rhBMP2_108 including 10, 50, 100, 200 and 500  ng/ml were compared to a commercially available rhBMP2 (100  ng/ml). Each of the working concentrations of rhBMP2_108 were investigated on MC3T3-E1 osteoblasts for their ability to induce osteoblast recruitment, proliferation and differentiation as assessed by @entity623 ( @entity623 ) staining, @entity622 staining, and real-time PCR for genes encoding @entity623 , @entity12502 ( @entity12502 ), collagen-1 (COL-1) and @entity8087 . RESULTS: The results demonstrate that all concentrations of rhBMP2_108 significantly improved cell recruitment and proliferation of osteoblasts at 5  days post seeding. Furthermore, rhBMP2_108 had the most pronounced effects on osteoblast differentiation. It was found that rhBMP2_108 had over a four fold significant increase in @entity623 activity at seven and 14  days post-seeding and the concentrations ranging from 50 to 200  ng/ml demonstrated the most pronounced effects. Analysis of real-time PCR for genes encoding @entity623 , @entity12502 , COL-1 and @entity8087 further confirmed dose-dependant increases at 14  days post-seeding. Furthermore, @entity622 staining demonstrated a concentration dependant increase in staining at 14  days. CONCLUSION: The results from the present study demonstrate that this shorter polypeptide chain of rhBMP2_108 is equally as bioactive as commercially available rhBMP2 for the recruitment of progenitor cells by facilitating their differentiation towards the osteoblast lineage. Future in vivo study are necessary to investigate its bioactivity.

title: Characterization of a shorter recombinant polypeptide chain of XXXX on osteoblast behaviour.

entities_list: @entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids']

entities_list: @entity622 :: ('MESH:C010078', 'Chemical') :: ['alizarin red']

entities_list: @entity623 :: ('250', 'Gene') :: ['ALP', 'alkaline phosphatase']

answer: @entity1841 :: (650,Gene) :: ['bone morphogenetic protein 2']


abstract: Conventional @entity1707 manure treatment is performed by anaerobic digestion, but @entity1568 is not treated. Microbial Fuel Cells (MFCs) allow organic matter and @entity1568 removal with concomitant electricity production. MFC microbiomes treating industrial wastewaters as @entity1707 manure have not been characterized. In this study, a multidisciplinary approach allowed microbiome relation with nutrient removal capacity and electricity production. Two different MFC configurations ( @entity37816 ) were used to treat @entity1707 manure. In C-1, the nitrification and denitrification processes took place in different compartments, while in @entity37816 , simultaneous nitrification-denitrification occurred in the cathode. Clostridium disporicum and @entity22137 were identified in the anode compartments of both systems. C. disporicum was related to the degradation of complex organic matter compounds and @entity22137 to electricity production. Different nitrifying bacteria populations were identified in both systems because of the different operational conditions. The highest microbial diversity was detected in cathode compartments of both configurations, including members of Bacteroidetes, Chloroflexiaceae and Proteobacteria. These communities allowed similar removal rates of organic matter (2.02-2.09kg CODm(-3)d(-1)) and @entity1568 (0.11-0.16kgNm(-3)d(-1)) in both systems. However, they differed in the generation of electric energy (20 and 2mWm(-3) in C-1 and @entity37816 , respectively).

title: Microbiome characterization of MFCs used for the treatment of XXXX manure.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity22137 :: ('35554', 'Species') :: ['Geobacter sulfurreducens', 'G. sulfurreducens']

answer: @entity1707 :: (9823,Species) :: ['swine']


abstract: BACKGROUND: We sought to determine the incidence of @entity204 due to surgical compromise of the coronary ostia in @entity886 . The mechanism of coronary ostium blockage was also investigated. METHODS: A retrospective review was conducted of prospectively collected clinical data and autopsy findings in 322 @entity1 who died in hospital after @entity886 with or without concomitant procedures in a single institution from January 1998 to March 2013. RESULTS: Over the 15-year period, more than 17 surgeons performed 7507 aortic valve replacements with or without other procedures. The mean age of the @entity1 was 70.8        11.78 years and 63% were male. Bioprosthetic valves were used in 75%, mechanical valves in 24.7%, and homografts in only 0.3%. Early mortality for all @entity1 (combined, emergency, and redo procedures) was 4.29% (mean logistic EuroSCORE 10.7). There were 322 deaths after procedures involving the aortic valve. Autopsy examinations were carried out in all @entity1 and showed that 3.4% (n   =   11) of deaths were at least partly attributed to encroachment on one or both coronary ostia. Causes of ostial compromise included the valve sutures, the valve sewing ring, and the aortotomy suture line. CONCLUSIONS: Coronary ostial compromise in @entity886 is a very rare but real problem occurring in at least 0.15% of aortic valve replacements and contributing to or directly causing one in every 29 @entity886 deaths. Surgeons should have a high level of awareness of the risk of this rare but fatal and avoidable complication.

title: Coronary ostial compromise in XXXX : An avoidable complication.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['hospital death']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve replacement']

answer: @entity886 :: (MESH:C563178,Disease) :: ['aortic valve replacement']


abstract: OBJECTIVE: Surgical detethering is a traditional treatment for symptomatic @entity601 . However, such complications as @entity5173 and @entity16 are common. Homogeneous spinal-shortening axial decompression (HSAD) is a modified procedure of monosegmental @entity4681 and it is a novel surgical alternative of reducing neural tension indirectly. The objective was to evaluate the surgical outcomes of HSAD for @entity601 . METHODS: The surgical outcomes were examined for 15 consecutive @entity1 with @entity601 undergoing HSAD from April 2010 to July 2014. Improvements of neurological symptoms including @entity1973 , @entity1109 and/or gait abnormalities, @entity1643 , @entity322 and @entity250 were evaluated. RESULTS: Their average follow-up period was 21.5 months. The length of spinal column shortening was 17.2    2.9 mm. @entity1973 (n = 9) was the most common residual deficit. All 9 @entity1 with @entity1109 reported improvements, although deficits persisted at the last follow-up. All @entity1 with @entity66 improved and 4 (50.0%) noted complete resolution of preoperative @entity1109 . All @entity1 reported immediate low-back or lower-extremity @entity158 relief after HSAD. One @entity1 reported improved sexual functioning and regained complete erectile capabilities. Two @entity1 (11%) experienced less satisfactory symptomatic or functional benefit from HSAD. However, the main objective of surgery was to prevent further worsening of neurological status. Complete bone union at osteotomy site was noted in all cases at the last follow-up. CONCLUSION: As a novel surgical option for @entity601 , HSAD may avoid such complications as @entity5173 or @entity16 commonly encountered during traditional detethering surgery. All @entity1 gain satisfactory functional outcomes without complications compared to their preoperative symptoms.

title: [Homogeneous spinal-shortening axial decompression procedure for XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low-back and/or lower-extremity pain']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['bowel incontinence']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['lower-extremity motor dysfunction']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic deterioration']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['urological symptoms', 'lower-extremity sensory symptoms', 'lower-extremity motor and sensory disturbances']

entities_list: @entity1973 :: ('MESH:D001750', 'Disease') :: ['Urinary dysfunction', 'urinary dysfunction']

entities_list: @entity4681 :: ('MESH:D016472', 'Disease') :: ['spinal-shortening osteotomy']

entities_list: @entity5173 :: ('MESH:D065634', 'Disease') :: ['cerebrospinal fluid leakage']

entities_list: @entity601 :: ('MESH:D009436', 'Disease') :: ['tethered cord syndrome']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity601 :: (MESH:D009436,Disease) :: ['tethered cord syndrome']


abstract: OBJECTIVE: To investigate incidence and clinical features of multiple organ involvement in Chinese @entity1 with @entity2314 . METHODS: We collected 151 @entity1 of 31 families with @entity2314 , all of whom were confirmed by classic pathology, @entity7791 A activity or @entity10153 mutation from the year of 2011 to 2014 in Department of Neurology, Peking University First Hospital. The clinical data included incidence and onset of @entity9 , @entity8 , @entity299 , @entity101 and @entity64 . We calculate the incidence of these symptoms and analyze their gender difference using chi-square with SPSS 17.0 software. RESULTS: Among 31 families with @entity2314 , 151 @entity1 (82 males and 69 females) were affected, including 91 @entity1 (60.26%) with @entity9 , 62 @entity1 (41.06%) with @entity8 , 33 @entity1 (21.85%) with @entity299 , 33 @entity1 (21.85%) with @entity101 , and 21 @entity1 (13.91%) with @entity64 . The peak incidence of @entity9 was from 10 to 20 years old, followed by @entity8 from 30 to 40 years old, @entity299 and @entity64 from 40 to 50 years old. There is no peak period for @entity101 . Except for males with higher incidence of @entity8 than females (P < 0.05), there were no gender difference in the incidence of other organ involvement. CONCLUSION: The incidence and onset of multiple organ dysfunction in Chinese @entity1 with @entity2314 displayed special regularity. Gender difference appeared only in @entity8 .

title: [Investigation of multiple organ involvement in XXXX ].

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease', 'renal dysfunction']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'cerebral stroke']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity7791 :: ('MESH:D016537', 'Disease') :: ['decreased a-galactosidase']

entities_list: @entity2314 :: ('MESH:D000795', 'Disease') :: ['Fabry disease']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuralgia']

answer: @entity2314 :: (MESH:D000795,Disease) :: ['Fabry disease']


abstract: UNASSIGNED: The GHEP-ISFG Working Group has recognized the importance of assisting DNA laboratories to gain expertise in handling DVI or missing @entity1 identification ( @entity17123 ) projects which involve the need for large-scale genetic profile comparisons. Eleven laboratories participated in a DNA matching exercise to identify victims from a hypothetical conflict with 193 missing @entity1 . The post mortem database was comprised of 87 skeletal remain profiles from a secondary mass grave displaying a minimal number of 58 individuals with evidence of commingling. The reference database was represented by 286 family reference profiles with diverse pedigrees. The goal of the exercise was to correctly discover re-associations and family matches. The results of direct matching for commingled remains re-associations were correct and fully concordant among all laboratories. However, the kinship analysis for missing @entity1 identifications showed variable results among the @entity1 . There was a group of laboratories with correct, concordant results but nearly half of the others showed discrepant results exhibiting likelihood ratio differences of several degrees of magnitude in some cases. Three main errors were detected: (a) some laboratories did not use the complete reference family genetic data to report the match with the remains, (b) the identity and/or non-identity hypotheses were sometimes wrongly expressed in the likelihood ratio calculations, and (c) many laboratories did not properly evaluate the prior odds for the event. The results suggest that large-scale profile comparisons for @entity17123 is a challenge for forensic genetics laboratories and the statistical treatment of DNA matching and the Bayesian framework should be better standardized among laboratories.

title: GHEP-ISFG collaborative simulated exercise for XXXX : Lessons learned about large-scale profile database comparisons.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'persons']

answer: @entity17123 :: (4351,Gene) :: ['DVI/MPI']


abstract: PURPOSE: To describe the retinal manifestations in @entity1619 ( @entity1619 ) related to an @entity281 by the @entity2662 ). METHODS: Retrospective case series of @entity1 with @entity1619 with retinal findings. RESULTS: A total of 175 @entity1 were diagnosed with @entity1619 in Martinique between 1983 and 2013. Three of them showed intraocular findings related to @entity1619 . They were bilateral @entity2479 associated with intermediate @entity1596 . In two cases, the @entity1619 diagnosis was known. In the third, @entity941 angiography was remarkable for @entity2479 although fundus examination was unremarkable. The @entity1619 cells were found in the blood of this @entity1 . Despite chemotherapy, infiltrates progressed from the retinal periphery to the posterior pole in two @entity1 , thus reducing visual acuity to light perception. They were associated with @entity1333 . CONCLUSION: Retinal involvement in @entity1619 is very rare. It can occur at any point during the natural course of the disease. @entity2662 carriers should benefit from a regular ophthalmic examination, and a @entity941 angiography must be performed in all @entity1 with @entity2662 with vitreous cells. The presence of @entity2479 must raise suspicion for @entity1619 in a @entity1 with @entity2662 .

title: RETINAL MANIFESTATIONS IN ADULT T-CELL LEUKEMIA/LYMPHOMA RELATED TO INFECTION BY THE XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1619 :: ('MESH:D015458', 'Disease') :: ['ATL', 'adult T-cell leukemia']

entities_list: @entity2479 :: ('MESH:D012173', 'Disease') :: ['deep retinal infiltrates']

entities_list: @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

entities_list: @entity2662 :: ('11908', 'Species') :: ['human T-cell lymphotropic virus type-1', 'human T-cell lymphotropic virus type-1 (HTLV-1', 'Human T-cell lymphotropic virus type-1']

answer: @entity2662 :: (11908,Species) :: ['HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1']


abstract: The feasibility of laparoscopic surgery for peritoneal @entity3 is still controversial. A 42-year-old male presenting with bloody stool underwent small intestinal fiberscopic examination. The biopsied specimens pathologically demonstrated @entity420 of the upper jejunum. Laparoscopy revealed a 10-mm nodule in the omentum. Laparoscopic partial jejunal resection with regional lymph node dissection was performed with combined resection of the nodule without conversion. No other @entity5 was detected. The resected specimen contained an irregular @entity5 measuring 52 x 33 mm. Microscopic examination revealed that the mass and peritoneal nodule comprised moderately differentiated @entity420 . After surgery, the @entity1 was treated with @entity4181 /bolus and infusional 5- @entity1487 / @entity901 for 6 months. Eleven months after surgery, a solitary peritoneal recurrence developed near the camera port site. Six months later, positron emission tomography, computer tomography, and exploratory laparotomy revealed multiple peritoneal recurrences. The @entity1 was then treated with @entity4181 /bolus and infusional @entity1487 / @entity2600 . Three months and 6 months later partial remission and complete response, respectively were sequentially induced. The @entity1 is alive 3 years and 9 months after initial surgery without any @entity5 recurrence. To our knowledge, this is the first report to demonstrate laparoscopic surgery combined with chemotherapy regimens, which induced a successful complete response.

title: Impact of laparoscopic surgery on survival of @entity1 with XXXX and peritoneal @entity3 .

entities_list: @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin']

entities_list: @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin']

entities_list: @entity2600 :: ('MESH:C051890', 'Chemical') :: ['irinotecan']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'ulcerative tumor']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil', '5-fluorouracil']

answer: @entity420 :: (MESH:D000230,Disease) :: ['small bowel adenocarcinoma']


abstract: The feasibility of laparoscopic surgery for peritoneal @entity3 is still controversial. A 42-year-old male presenting with bloody stool underwent small intestinal fiberscopic examination. The biopsied specimens pathologically demonstrated @entity420 of the upper jejunum. Laparoscopy revealed a 10-mm nodule in the omentum. Laparoscopic partial jejunal resection with regional lymph node dissection was performed with combined resection of the nodule without conversion. No other @entity5 was detected. The resected specimen contained an irregular @entity5 measuring 52 x 33 mm. Microscopic examination revealed that the mass and peritoneal nodule comprised moderately differentiated @entity420 . After surgery, the @entity1 was treated with @entity4181 /bolus and infusional 5- @entity1487 / @entity901 for 6 months. Eleven months after surgery, a solitary peritoneal recurrence developed near the camera port site. Six months later, positron emission tomography, computer tomography, and exploratory laparotomy revealed multiple peritoneal recurrences. The @entity1 was then treated with @entity4181 /bolus and infusional @entity1487 / @entity2600 . Three months and 6 months later partial remission and complete response, respectively were sequentially induced. The @entity1 is alive 3 years and 9 months after initial surgery without any @entity5 recurrence. To our knowledge, this is the first report to demonstrate laparoscopic surgery combined with chemotherapy regimens, which induced a successful complete response.

title: Impact of laparoscopic surgery on survival of @entity1 with @entity420 and peritoneal XXXX .

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: The feasibility of laparoscopic surgery for peritoneal @entity3 is still controversial. A 42-year-old male presenting with bloody stool underwent small intestinal fiberscopic examination. The biopsied specimens pathologically demonstrated @entity420 of the upper jejunum. Laparoscopy revealed a 10-mm nodule in the omentum. Laparoscopic partial jejunal resection with regional lymph node dissection was performed with combined resection of the nodule without conversion. No other @entity5 was detected. The resected specimen contained an irregular @entity5 measuring 52 x 33 mm. Microscopic examination revealed that the mass and peritoneal nodule comprised moderately differentiated @entity420 . After surgery, the @entity1 was treated with @entity4181 /bolus and infusional 5- @entity1487 / @entity901 for 6 months. Eleven months after surgery, a solitary peritoneal recurrence developed near the camera port site. Six months later, positron emission tomography, computer tomography, and exploratory laparotomy revealed multiple peritoneal recurrences. The @entity1 was then treated with @entity4181 /bolus and infusional @entity1487 / @entity2600 . Three months and 6 months later partial remission and complete response, respectively were sequentially induced. The @entity1 is alive 3 years and 9 months after initial surgery without any @entity5 recurrence. To our knowledge, this is the first report to demonstrate laparoscopic surgery combined with chemotherapy regimens, which induced a successful complete response.

title: Impact of laparoscopic surgery on survival of XXXX with @entity420 and peritoneal @entity3 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND/AIMS: Age, sex, gene and life style are modulating risks for @entity694 . Although @entity167 intake may impact on @entity2513 , clear association has not been established yet. We aimed to investigate effects of @entity167 consumption on the characteristics of @entity2513 . METHODS: @entity1 who underwent colonoscopic polypectomy of @entity2513 in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The @entity167 drinking @entity1 were subdivided into normal or abnormal laboratory group, and @entity5881 group. RESULTS: 212 @entity1 with @entity2513 were analyzed; advanced @entity652 and multiple @entity652 were found in 68 (32.0%) and 79 (37.2%) @entity1 . When compared to the nondrinker group (120/212 @entity1 ), the @entity167 drinker group (92/212 @entity1 ) represented significantly high odds ratios (ORs) for advanced @entity652 (OR, 2.697; P=0.002), and multiple @entity652 (OR, 1.929; P=0.039). Among @entity167 drinker (92 @entity1 ), the ORs of advanced @entity652 were 6.407 (P=0.003) in @entity5881 group (17 @entity1 ), 3.711 (P=0.002) in the @entity167 drinker with abnormal lab (24 @entity1 ), and 2.184 (P=0.034), in the @entity167 drinker with normal lab (51 @entity1 ) compared to nondrinker group. CONCLUSIONS: This study showed that @entity167 drinking may influence on the development of advanced @entity2513 and multiplicity. Especially in the group with @entity5881 and with abnormal lab presented significantly higher ORs of advanced @entity652 .

title: @entity167 drinking increased the risk of advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5881 :: ('MESH:D008108', 'Disease') :: ['alcoholic liver diseases']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenoma']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenomas']


abstract: BACKGROUND/AIMS: Age, sex, gene and life style are modulating risks for @entity694 . Although @entity167 intake may impact on @entity2513 , clear association has not been established yet. We aimed to investigate effects of @entity167 consumption on the characteristics of @entity2513 . METHODS: @entity1 who underwent colonoscopic polypectomy of @entity2513 in the department of gastroenterology of Eulji hospital through 2005 to 2012, having both blood tests and ultrasound or abdominal CT examination were enrolled. The @entity167 drinking @entity1 were subdivided into normal or abnormal laboratory group, and @entity5881 group. RESULTS: 212 @entity1 with @entity2513 were analyzed; advanced @entity652 and multiple @entity652 were found in 68 (32.0%) and 79 (37.2%) @entity1 . When compared to the nondrinker group (120/212 @entity1 ), the @entity167 drinker group (92/212 @entity1 ) represented significantly high odds ratios (ORs) for advanced @entity652 (OR, 2.697; P=0.002), and multiple @entity652 (OR, 1.929; P=0.039). Among @entity167 drinker (92 @entity1 ), the ORs of advanced @entity652 were 6.407 (P=0.003) in @entity5881 group (17 @entity1 ), 3.711 (P=0.002) in the @entity167 drinker with abnormal lab (24 @entity1 ), and 2.184 (P=0.034), in the @entity167 drinker with normal lab (51 @entity1 ) compared to nondrinker group. CONCLUSIONS: This study showed that @entity167 drinking may influence on the development of advanced @entity2513 and multiplicity. Especially in the group with @entity5881 and with abnormal lab presented significantly higher ORs of advanced @entity652 .

title: XXXX drinking increased the risk of advanced @entity2513 .

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['Alcohol']


abstract: Mesenchymal stem cells (MSCs) have been proposed as a potential therapeutic tool for @entity191 ( @entity191 ) and systemic administration of these cells has been tested in preclinical and clinical studies. However, no information on survival and actual capacity of MSCs to reach the brain has been provided. In this study, we evaluated homing of intraarterially infused @entity35 MSCs (rMSCs) in the brain of @entity35 bearing a @entity2955 ( @entity2955 )-induced lesion of the nigrostriatal tract, to establish whether the toxin-induced damage is sufficient to grant MSC passage across the blood-brain barrier (BBB) or if a transient BBB disruption is necessary. The rMSC distribution in peripheral organs and the effects of cell infusion on neurodegenerative process and @entity51 were also investigated. rMSCs were infused 14 days after @entity2955 injection. A hyperosmolar solution of @entity2656 was used to transiently permeabilize the BBB. @entity146 was assessed by adjusting step test and response to @entity3826 . Animals were sacrificed 7 and 28 days after cell infusion. Our work shows that appreciable delivery of rMSCs to the brain of @entity2955 -lesioned animals can be obtained only after @entity2656 pretreatment. A notable percentage of infused cells accumulated in peripheral organs. Infusion of rMSCs did not modify the progression of @entity2955 -induced @entity16 at the stepping test, but induced progressive normalization of the pathological response (contralateral turning) to @entity3826 administration. These findings suggest that many aspects should be further investigated before considering any translation of MSC systemic administration into the clinical setting for @entity191 treatment. SIGNIFICANCE: This study demonstrates that mesenchymal stem cells infused through the carotid artery do not efficiently cross the blood-brain barrier in @entity35 with a @entity528 , unless a permeabilizing agent (e.g., @entity2656 ) is used. The infusion did not reduce the @entity528 and associated @entity73 , but abolished the motor abnormalities these animals typically show when challenged with a dopaminergic agonist. Therefore, although arterially infused mesenchymal stem cells did not show neurorestorative effects in this study's @entity191 model, they appeared to normalize the pathological responsiveness of striatal neurons to dopaminergic stimulation. This capability should be further explored in future studies.

title: Intracarotid Infusion of Mesenchymal Stem Cells in an Animal Model of XXXX , Focusing on Cell Distribution and Neuroprotective and Behavioral Effects.

entities_list: @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Behavioral impairment']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['motor impairment']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['damage or the motor impairment']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['motor deficits']

entities_list: @entity3826 :: ('MESH:D001058', 'Chemical') :: ['apomorphine']

entities_list: @entity2955 :: ('MESH:D016627', 'Chemical') :: ['6-hydroxydopamine', '6-OHDA']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal damage', "Parkinson's disease-like degeneration of nigrostriatal neurons"]

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's Disease']


abstract: UNASSIGNED: @entity12732 miyamotoi, a member of the relapsing @entity221 group borreliae, was first isolated in Japan and subsequently found in Ixodes ticks in North America, Europe and Russia. Currently, there are three types of B. miyamotoi: Asian or Siberian (transmitted mainly by @entity10054 ), European (Ixodesricinus) and American (Ixodesscapularis and Ixodespacificus). Despite the great genetic distances between B. miyamotoi types, isolates within a type are characterised by an extremely low genetic variability. In particular, strains of B. miyamotoi of Asian type, isolated in Russia from the Baltic sea to the Far East, have been shown to be identical based on the analysis of several conventional genetic markers, such as 16S rRNA, flagellin, outer membrane protein p66 and glpQ genes. Thus, protein or rRNA - coding genes were shown not to be informative enough in studying genetic diversity of B. miyamotoi within a type. In the present paper, we have attempted to design a new multilocus technique based on eight non-coding intergenic spacers (3686bp in total) and have applied it to the analysis of intra-type genetic variability of   . miyamotoi detected in different regions of Russia and from two tick species, @entity10054 and Ixodespavlovskyi. However, even though potentially the most variable loci were selected, no genetic variability between studied DNA samples was found, except for one @entity377 substitution in two of them. The sequences obtained were identical to those of the reference strain FR64b. Analysis of the data obtained with the GenBank sequences indicates a highly homogeneous genetic background of B. miyamotoi from the Baltic Sea to the Japanese Islands. In this paper, a hypothesis of clonal expansion of B. miyamotoi is discussed, as well as possible mechanisms for the rapid dissemination of one B. miyamotoi clone over large distances.

title: Multilocus spacer analysis revealed highly homogeneous genetic background of Asian type of XXXX miyamotoi.

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity10054 :: ('34615', 'Species') :: ['Ixodes persulcatus', 'I. persulcatus']

answer: @entity12732 :: (MESH:D001899,Disease) :: ['Borrelia']


abstract: UNASSIGNED: @entity22968 ( @entity22968 ) is a mosquito-transmitted Flavivirus belonging to the Japanese @entity198 antigenic complex of the Flaviviridae family. Its spread in the Mediterranean basin and the Balkans poses a significant risk to @entity1 health and forces public health officials to constantly monitor the virus transmission to ensure prompt application of preventive measures. In this context, predictive tools indicating the areas and periods at major risk of @entity22968 transmission are of paramount importance. Spatial analysis approaches, which use environmental and climatic variables to find suitable habitats for @entity22968 spread, can enhance predictive techniques. Using the Mahalanobis Distance statistic, areas ecologically most suitable for sustaining @entity22968 transmission were identified in the Mediterranean basin and Central Europe. About 270 @entity1 and @entity1641 clinical cases notified in Italy, Greece, Portugal, Morocco, and Tunisia, between 2008 and 2012, have been considered. The environmental variables included in the model were altitude, slope, night time Land Surface Temperature, Normalized Difference Vegetation Index, Enhanced Vegetation Index, and daily temperature range. Seasonality of mosquito population has been modelled and included in the analyses to produce monthly maps of suitable areas for @entity26344 . Between May and July, the most suitable areas are located in Tunisia, Libya, Egypt, and North Cyprus. Summer/Autumn months, particularly between August and October, characterize the suitability in Italy, France, Spain, the Balkan countries, Morocco, North Tunisia, the Mediterranean coast of Africa, and the Middle East. The persistence of suitable conditions in December is confined to the coastal areas of Morocco, Tunisia, Libya, Egypt, and Israel.

title: Spatio-Temporal Identification of Areas Suitable for XXXX in the Mediterranean Basin and Central Europe.

entities_list: @entity26344 :: ('MESH:D014901', 'Disease') :: ['West Nile Disease']

entities_list: @entity198 :: ('MESH:D004660', 'Disease') :: ['encephalitis']

entities_list: @entity22968 :: ('11082', 'Species') :: ['WNV', 'West Nile virus']

answer: @entity26344 :: (MESH:D014901,Disease) :: ['West Nile Disease']


abstract: UNASSIGNED: @entity458 ( @entity458 ) increases vulnerability for @entity1005 ( @entity1005 ). @entity458 is also associated with increased risk for developing @entity4225 ( @entity4225 ). Research has also documented a significant link between @entity1005 and @entity4225 ; however, there is a paucity of information examining this relationship among veterans with @entity458 -related @entity1005 . In particular, we sought to examine whether comorbid @entity4225 - @entity1005 compared with veterans with @entity1005 and no @entity4225 resulted in increased @entity1005 and @entity308 symptomatology. We also examined @entity146 , previous @entity458 , and demographic factors to determine what-if any-factors were associated with comorbid @entity4225 diagnosis. Using data from a recently conducted randomized clinical trial, we examined electronic medical records of the local Veterans Affairs Medical Center. Data from 90 veterans with @entity458 -related @entity1005 were obtained. More than 22% (n = 20) of the sample had a historical diagnosis of @entity4225 . @entity1 were administered measures to assess @entity146 symptomatology ( @entity1005 and @entity308 ), @entity130 -related negative cognitions (NCs), and previous sexual traumatization (e.g., childhood and civilian sexual exposure). An analysis of variance was conducted, which found that veterans with comorbid @entity458 -related @entity1005 and @entity4225 had significantly greater @entity1005 criterion B (avoidance) symptoms, @entity308 symptomatology, and NC scores than @entity1 without comorbid @entity4225 . In addition, a binary stepwise logistic regression found that veterans' @entity4225 was also positively associated with NCs about self and the world; however, self-blame, @entity308 , @entity1005 , sociodemographic variables (e.g., gender, age), and previous sexual traumatizations were not significant predictors. Implications are discussed with regard to clinical care and future research directions.

title: XXXX and @entity458 : Analysis of Previous Traumatization and Current Psychiatric Presentation.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depressive']

entities_list: @entity4225 :: ('MESH:D001883', 'Disease') :: ['borderline personality disorder', 'BPD']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['Military sexual trauma', 'MST', 'sexual trauma', 'Sexual trauma']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['posttraumatic stress disorder', 'PTSD']

answer: @entity4225 :: (MESH:D001883,Disease) :: ['Borderline Personality Disorder']


abstract: UNASSIGNED: @entity458 ( @entity458 ) increases vulnerability for @entity1005 ( @entity1005 ). @entity458 is also associated with increased risk for developing @entity4225 ( @entity4225 ). Research has also documented a significant link between @entity1005 and @entity4225 ; however, there is a paucity of information examining this relationship among veterans with @entity458 -related @entity1005 . In particular, we sought to examine whether comorbid @entity4225 - @entity1005 compared with veterans with @entity1005 and no @entity4225 resulted in increased @entity1005 and @entity308 symptomatology. We also examined @entity146 , previous @entity458 , and demographic factors to determine what-if any-factors were associated with comorbid @entity4225 diagnosis. Using data from a recently conducted randomized clinical trial, we examined electronic medical records of the local Veterans Affairs Medical Center. Data from 90 veterans with @entity458 -related @entity1005 were obtained. More than 22% (n = 20) of the sample had a historical diagnosis of @entity4225 . @entity1 were administered measures to assess @entity146 symptomatology ( @entity1005 and @entity308 ), @entity130 -related negative cognitions (NCs), and previous sexual traumatization (e.g., childhood and civilian sexual exposure). An analysis of variance was conducted, which found that veterans with comorbid @entity458 -related @entity1005 and @entity4225 had significantly greater @entity1005 criterion B (avoidance) symptoms, @entity308 symptomatology, and NC scores than @entity1 without comorbid @entity4225 . In addition, a binary stepwise logistic regression found that veterans' @entity4225 was also positively associated with NCs about self and the world; however, self-blame, @entity308 , @entity1005 , sociodemographic variables (e.g., gender, age), and previous sexual traumatizations were not significant predictors. Implications are discussed with regard to clinical care and future research directions.

title: @entity4225 and XXXX : Analysis of Previous Traumatization and Current Psychiatric Presentation.

answer: @entity458 :: (MESH:D020018,Disease) :: ['Military Sexual Trauma']


abstract: PURPOSE: Non-traumatic spontaneous @entity1410 of the rectus abdominal muscle is not considered a critical condition. Nevertheless, it can be a serious complication in some @entity1 due to continuous and/or consistent @entity548 . The most frequent cause of spontaneous rectus @entity121 is the anticoagulation therapy. The natural history of rectus @entity121 usually leads to a positive outcome and can be spontaneously self-limited only by conservative therapy. Nevertheless, in some @entity1 , despite a correct and early medical therapy, the continuous @entity548 requests a more radical handling. Up to now, the surgical @entity1410 evacuation and the bonding of blood vessels were considered the most appropriate treatment, while at present, the percutaneous management by means of selective catheters and embolization of the @entity548 vessel is considered to be the most used option. Our purpose is to report our experience in the @entity121 treatment in the elderly @entity1 . MATERIALS AND METHODS: From the data base and medical reports of the hospital, we selected 144 medical reports. We focused on those cases that showed the following criteria: @entity1 with rectus @entity121 undergoing anticoagulation therapy and/or non-traumatic spontaneous @entity1410 and with persistent @entity548 revealed on CT examination despite a pharmacological treatment aimed to timely reverse @entity1003 . These criteria were found in 18 @entity1 : 15 females and 3 males, with a median age of 73 (range 64-81). In all @entity1 , the diagnosis had been confirmed by an abdominal CT in emergency setting, performed before and after contrast medium intravenous administration. Because of clinical conditions, all @entity1 had been moved on the angiographic room for diagnostic arteriography and embolization. The criteria for this treatment were @entity1344 and the continuous @entity548 despite the correct medical therapy. RESULTS: CT imaging detected rectus @entity121 in 18/18 @entity1 and active @entity548 in 7/18 @entity1 . Selective catheterization was applied to all 18 @entity1 ; arteriographic study confirmed the information of the CT study in all of the seven @entity1 . The inferior epigastric artery was the main cause of the @entity548 in all 18 @entity1 . In 14 @entity1 , one single vessel was responsible for the @entity548 , while in the other four @entity1 , more than one vessel were involved: In two @entity1 , we also found the involvement of the superior epigastric artery; while the other two @entity1 showed also the involvement of the deep iliac circumflex artery. The material for embolization was compatible coils with micro-catheters in 17/18 @entity1 , and glue for 1/18 @entity1 . CONCLUSIONS: @entity1 with large rectus @entity121 , which have not yet recovered with conservative therapy, should then consider undergoing endovascular treatment. This procedure is highly recommended in @entity1 with other coexisting pathologies that could eventually lead to a fatal outcome. It is difficult to determine when surgery is necessary when there is very poor data provided by scientific literature review, so the decision to use surgery can be suggested when embolization is unsuccessful or when it is necessary to evacuate a complex huge fluid mass in peritoneal cavity.

title: Endovascular management of the rectus XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathy']

entities_list: @entity1344 :: ('MESH:D043171', 'Disease') :: ['hemodynamic instability']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['endovascular spontaneous rectus muscle bleeding', 'muscle hematoma']

answer: @entity121 :: (MESH:D009135,Disease) :: ['muscle hematoma']


abstract: A new micellar electrokinetic chromatography (MEKC) method was developed and validated for the analysis of @entity1405 and @entity1169 in @entity1 urine samples. In this study, vortex-assisted liquid-liquid extraction (VALLE) coupled with field-amplified sample injection and sweeping was employed for biological sample clean-up and sensitivity enhancement in MEKC. After VALLE, the urine samples were analyzed by MEKC. @entity71549 buffer (60mmolL(-1), pH 2.0) containing 40% (v/v) @entity1042 was first filled into an uncoated fused- @entity3440 capillary (56cm, 50  m i.d.). The pretreated urine sample was loaded by electrokinetic injection (10kV, 250s). The stacking and separation were performed using @entity71549 buffer (30mmolL(-1), pH 3.0) containing 30% (v/v) @entity1042 and 50mmolL(-1) @entity3208 ( @entity214 ) at -25kV. Detection was carried out at 195 and 214nm for @entity1405 and @entity1169 , respectively. The suggested method is linear (r(2)>= 0.997) over a dynamic range of 0.005-1  gmL(-1) in urine. The intra- and inter-day relative standard deviation and relative error values of the method were below 20%, which shows good precision and accuracy. Finally, this method was successfully applied to the analysis of real urine samples.

title: Vortex-assisted liquid-liquid extraction combined with field-amplified sample injection and sweeping micellar electrokinetic chromatography for improved determination of b-blockers in XXXX urine.

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecyl sulfate']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity71549 :: ('CHEBI:67098', 'Chemical') :: ['Tris-phosphate']

entities_list: @entity1405 :: ('MESH:C043211', 'Chemical') :: ['carvedilol']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: @entity579 black-streaked dwarf disease, caused by @entity71550 ), is transmitted by @entity62735 ( @entity62735 Fall  n, SBPH) and causes severe yield loss in epidemic years in China and other East Asian countries. Breeding for resistance to @entity71550 is a promising strategy to control the disease. We identified Tetep that showed resistance to @entity71550 using a field test and artificial inoculation test. An evaluation of the resistance mechanism revealed that Tetep was resistant to @entity71550 but not to SBPH. Genetic analysis showed that the resistance of Tetep to @entity71550 was controlled by quantitative trait loci (QTLs). Three new QTLs for @entity71550 resistance were identified in this study, i.e., qRBSDV-3, qRBSDV-10 and qRBSDV-11. The LOD scores of qRBSDV-3, qRBSDV-10 and qRBSDV-11 were 4.07, 2.24 and 2.21, accounting for 17.5%, 0.3% and 12.4% of the total phenotypic variation, respectively. All the resistance loci identified in this study were associated with virus resistance genes. The alleles for enhancing resistance on chromosomes 3 and 11 originated from Tetep, whereas the other allele on chromosome 10 originated from a susceptible parent. The identified new resistance QTLs in this study are useful resources for efficiently breeding resistant @entity579 cultivars to @entity71550 .

title: Genetic analysis and molecular mapping of QTLs for resistance to XXXX black-streaked dwarf disease in @entity579 .

entities_list: @entity62735 :: ('195883', 'Species') :: ['Laodelphax striatellus', 'small brown planthoppers']

entities_list: @entity71550 :: ('10990', 'Species') :: ['RBSDV', 'rice black-streaked dwarf virus (RBSDV']

answer: @entity579 :: (4530,Species) :: ['rice']


abstract: @entity579 black-streaked dwarf disease, caused by @entity71550 ), is transmitted by @entity62735 ( @entity62735 Fall  n, SBPH) and causes severe yield loss in epidemic years in China and other East Asian countries. Breeding for resistance to @entity71550 is a promising strategy to control the disease. We identified Tetep that showed resistance to @entity71550 using a field test and artificial inoculation test. An evaluation of the resistance mechanism revealed that Tetep was resistant to @entity71550 but not to SBPH. Genetic analysis showed that the resistance of Tetep to @entity71550 was controlled by quantitative trait loci (QTLs). Three new QTLs for @entity71550 resistance were identified in this study, i.e., qRBSDV-3, qRBSDV-10 and qRBSDV-11. The LOD scores of qRBSDV-3, qRBSDV-10 and qRBSDV-11 were 4.07, 2.24 and 2.21, accounting for 17.5%, 0.3% and 12.4% of the total phenotypic variation, respectively. All the resistance loci identified in this study were associated with virus resistance genes. The alleles for enhancing resistance on chromosomes 3 and 11 originated from Tetep, whereas the other allele on chromosome 10 originated from a susceptible parent. The identified new resistance QTLs in this study are useful resources for efficiently breeding resistant @entity579 cultivars to @entity71550 .

title: Genetic analysis and molecular mapping of QTLs for resistance to @entity579 black-streaked dwarf disease in XXXX .

answer: @entity579 :: (4530,Species) :: ['rice']


abstract: PURPOSE: To evaluate an @entity717 for @entity8244 . METHODS: Nine @entity1 (5 @entity1 and 4 @entity1 aged 6 to 13 years) with @entity8244 were treated with @entity717 . Magnetic resonance imaging of the elbow showed the proximal radioulnar joint on the anterior-lateral side of the ulna rather than on the lateral side in @entity1 with @entity8244 . On the basis of this finding, we performed an osteotomy on the ulna and laterally rotated the proximal radioulnar joint achieving radial head reduction and restoring the anatomical relationship between the radial head and the capitellum. Clinical and radiographical evaluation of the elbow was performed before surgery and at postoperative follow-up. RESULTS: All @entity1 were followed for 13 to 45 months after surgery. Elbow radiography showed that the radiocapitellar joint was reduced in all @entity1 at the last follow-up visit and that the carrying angle was decreased relative to that in the preoperative condition. Elbow stability and the range of @entity11535 were improved at the last follow-up. We did not observe ulnar osteotomy site nonunion or @entity571 in these @entity1 . Furthermore, @entity8244 did not recur. CONCLUSIONS: At early follow-up, @entity717 was a safe and effective method for the treatment of @entity8244 . TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic IV.

title: Ulnar Rotation Osteotomy for Congenital XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'girls', 'boys']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['elbow osteoarthritis']

entities_list: @entity8244 :: ('MESH:C566728', 'Disease') :: ['congenital anterior dislocation of the radial head', 'radial head dislocation']

entities_list: @entity11535 :: ('MESH:D009041', 'Disease') :: ['elbow flexion motion']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['ulnar rotation osteotomy']

answer: @entity8244 :: (MESH:C566728,Disease) :: ['Radial Head Dislocation']


abstract: UNASSIGNED: The objective of this study was to investigate the relationship between IGFs produced in the liver and skeletal muscle with @entity2086 previously observed in a line of GH-transgenic @entity3392 . In this sense, we evaluated the expression of genes related to the IGF system in liver and muscle of transgenics, as well as the main intracellular signaling pathways used by GH/IGF axis. Our results showed an increase in expression of @entity22819 , @entity22820 , and @entity22822 genes in the liver. Moreover, there was a decrease in the expression of @entity37650 and an increase in muscle igf2r of transgenics, indicating a negative response of muscle tissue with respect to excess circulating IGFs. Muscle IGFs expression analyses revealed a significant increase only for @entity22822 , accompanied by a parallel induction of @entity71551 gene. The presence of @entity71551 may potentiate the @entity22820 action in muscle cells differentiation. Regarding JAK/ @entity71552 -related genes, we observed an alteration in the expression profile of both @entity61096 and @entity71553 in transgenic fish liver. No changes were observed in the muscle, suggesting that both tissues respond differently to GH-transgenesis. Western blotting analyses indicated an imbalance between the phosphorylation levels of the proliferative (MEK/ERK) and @entity1184 (PI3K/Akt) pathways, in favor of the latter. In summary, the results of this study suggest that the @entity1184 caused by GH-transgenesis in @entity3392 may be due to circulating IGFs produced by the liver, with an important participation of muscle @entity22822 . This group of IGFs appears to be favoring the @entity1184 intracellular pathway in muscle tissue of transgenic @entity3392 .

title: Expression profile of IGF paralog genes in liver and muscle of a GH-transgenic XXXX .

entities_list: @entity2086 :: ('MESH:C536106', 'Disease') :: ['muscle hypertrophy']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic', 'hypertrophy']

answer: @entity3392 :: (7955,Species) :: ['zebrafish']


abstract: A few reports have provided histopathological insight into @entity120 developing after antitumor chemotherapy. In general, @entity358 is a commonly observed finding in @entity1 with severe @entity120 . We herein report a novel pathological finding that may characterize the histopathological change occurring in @entity1 with @entity120 after chemotherapy for @entity5 . Lung biopsy or autopsy was performed in 7 @entity1 with @entity120 that developed during or after chemotherapy between 2006 and 2013 to examine the pulmonary vascular changes or to determine the cause of @entity204 . Pathological findings included in situ @entity715 in the small pulmonary arteries in 4 of 7 @entity1 . In 2 of 4 @entity1 , @entity120 was controlled by anticoagulants and antithrombotic agents. One @entity1 who had organized thrombi attained spontaneous remission with @entity26 therapy. The other @entity1 died of sudden @entity1167 during chemotherapy. Autopsy showed complete occlusion of the peripheral small pulmonary arteries and veins by thrombi. These results demonstrate that in situ @entity715 in the small pulmonary arteries could cause @entity120 after chemotherapy.

title: In situ @entity715 of small pulmonary arteries in XXXX developing after chemotherapy for @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['plexogenic pulmonary arteriopathy']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiopulmonary arrest']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity120 :: (MESH:D006976,Disease) :: ['pulmonary hypertension']


abstract: A few reports have provided histopathological insight into @entity120 developing after antitumor chemotherapy. In general, @entity358 is a commonly observed finding in @entity1 with severe @entity120 . We herein report a novel pathological finding that may characterize the histopathological change occurring in @entity1 with @entity120 after chemotherapy for @entity5 . Lung biopsy or autopsy was performed in 7 @entity1 with @entity120 that developed during or after chemotherapy between 2006 and 2013 to examine the pulmonary vascular changes or to determine the cause of @entity204 . Pathological findings included in situ @entity715 in the small pulmonary arteries in 4 of 7 @entity1 . In 2 of 4 @entity1 , @entity120 was controlled by anticoagulants and antithrombotic agents. One @entity1 who had organized thrombi attained spontaneous remission with @entity26 therapy. The other @entity1 died of sudden @entity1167 during chemotherapy. Autopsy showed complete occlusion of the peripheral small pulmonary arteries and veins by thrombi. These results demonstrate that in situ @entity715 in the small pulmonary arteries could cause @entity120 after chemotherapy.

title: In situ @entity715 of small pulmonary arteries in @entity120 developing after chemotherapy for XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignancy']


abstract: A few reports have provided histopathological insight into @entity120 developing after antitumor chemotherapy. In general, @entity358 is a commonly observed finding in @entity1 with severe @entity120 . We herein report a novel pathological finding that may characterize the histopathological change occurring in @entity1 with @entity120 after chemotherapy for @entity5 . Lung biopsy or autopsy was performed in 7 @entity1 with @entity120 that developed during or after chemotherapy between 2006 and 2013 to examine the pulmonary vascular changes or to determine the cause of @entity204 . Pathological findings included in situ @entity715 in the small pulmonary arteries in 4 of 7 @entity1 . In 2 of 4 @entity1 , @entity120 was controlled by anticoagulants and antithrombotic agents. One @entity1 who had organized thrombi attained spontaneous remission with @entity26 therapy. The other @entity1 died of sudden @entity1167 during chemotherapy. Autopsy showed complete occlusion of the peripheral small pulmonary arteries and veins by thrombi. These results demonstrate that in situ @entity715 in the small pulmonary arteries could cause @entity120 after chemotherapy.

title: In situ XXXX of small pulmonary arteries in @entity120 developing after chemotherapy for @entity5 .

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombosis']


abstract: A case of 19-year-old male @entity1 reported with the chief complaint of slowly growing diffuse @entity4 over the right part of the face from last 6 months. Intraoral examination revealed a swelling on right side of palate in relation to molar region with buccal cortical plate expansion. Radiographic examination (orthopantograph and 3DCT) showed large multilocular radiolucency in right maxilla with generalized @entity393 . Incisional biopsy was done and specimen was sent for histopathological examination which showed multinucleated giant cells containing 15-30 nuclei. Based on clinical, radiological, and histopathological findings provisional diagnosis of @entity2253 was made. Blood tests after histopathology demonstrated elevated serum @entity460 level and alkaline phosphatase level. Immunoassay of @entity461 ( @entity461 ) level was found to be highly elevated. Radiographic examination of long bones like humerus and femur, mandible, and skull was also done which showed @entity75 . Considering the clinical, radiographic, histopathological, and blood investigation findings, final diagnosis of @entity5 of maxilla was made. The @entity1 underwent partial parathyroidectomy under general anaesthesia to control @entity459 . Surgical @entity75 was done by curettage. The @entity1 has been followed up for 1 year with no @entity260 and the lesion healed uneventfully.

title: @entity2253 : first expression of XXXX .

entities_list: @entity459 :: ('MESH:D049950', 'Disease') :: ['primary hyperparathyroidism']

entities_list: @entity2253 :: ('MESH:D006101', 'Disease') :: ['central giant cell granuloma']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['osteoclastic lesions', 'removal of the bony lesion']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['painless swelling']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['brown tumour']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['loss of lamina dura']

entities_list: @entity461 :: ('5741', 'Gene') :: ['PTH', 'parathyroid hormone']

answer: @entity459 :: (MESH:D049950,Disease) :: ['primary hyperparathyroidism']