abstract: We report a paradoxical effect of @entity1092 ( @entity2052 ) observed in a 3-year-old @entity1 with cryptogenic localization-related @entity302 . On admission she experienced two types of @entity410 that were confirmed by ictal EEGs : @entity410 ( @entity410 ) originating from the left hemisphere and combined @entity410 that began with repetitive @entity410 immediately followed by a @entity38761 . These @entity410 did not possess asymmetrical features, but the ictal EEGs showed left-side dominant multiple spike-waves. The patent's interictal EEGs on admission showed left posterior temporal- parietal spikes during wakefulness and frequent diffuse spike-waves during sleep. In the process of introduction and increase in the dosage of @entity2052 , an aggravation of @entity302 discharges, especially a dramatic increase in diffuse spike-waves during sleep, was observed. In the same period of time, @entity410 not followed by @entity38761 newly appeared, and there was an increase in the frequency of @entity410 and combined @entity410 . Marked improvement of @entity302 discharges, namely the disappearance of diffuse discharges, and complete suppression of all types of @entity410 were achieved by the introduction of @entity2049 ( @entity2050 ) along with the withdrawal of @entity2052 . During the clinical course, the @entity1 did not display any signs or symptoms of @entity2052 @entity198 , @entity1445 of @entity2052 or metabolic aberration. The paradoxical effect of @entity2050 in localization-related @entity302 is well-known, yet in this case, @entity2052 displayed a similar paradoxical effect. Additionally, @entity2050 was efficacious in the suppression of secondary bilateral synchrony on EEG and also successfully controlled @entity410 , combined @entity410 and @entity410 .

title: [Aggravation of XXXX by @entity1092 in a @entity1 with cryptogenic localization-related @entity302 ].

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: We report a paradoxical effect of @entity1092 ( @entity2052 ) observed in a 3-year-old @entity1 with cryptogenic localization-related @entity302 . On admission she experienced two types of @entity410 that were confirmed by ictal EEGs : @entity410 ( @entity410 ) originating from the left hemisphere and combined @entity410 that began with repetitive @entity410 immediately followed by a @entity38761 . These @entity410 did not possess asymmetrical features, but the ictal EEGs showed left-side dominant multiple spike-waves. The patent's interictal EEGs on admission showed left posterior temporal- parietal spikes during wakefulness and frequent diffuse spike-waves during sleep. In the process of introduction and increase in the dosage of @entity2052 , an aggravation of @entity302 discharges, especially a dramatic increase in diffuse spike-waves during sleep, was observed. In the same period of time, @entity410 not followed by @entity38761 newly appeared, and there was an increase in the frequency of @entity410 and combined @entity410 . Marked improvement of @entity302 discharges, namely the disappearance of diffuse discharges, and complete suppression of all types of @entity410 were achieved by the introduction of @entity2049 ( @entity2050 ) along with the withdrawal of @entity2052 . During the clinical course, the @entity1 did not display any signs or symptoms of @entity2052 @entity198 , @entity1445 of @entity2052 or metabolic aberration. The paradoxical effect of @entity2050 in localization-related @entity302 is well-known, yet in this case, @entity2052 displayed a similar paradoxical effect. Additionally, @entity2050 was efficacious in the suppression of secondary bilateral synchrony on EEG and also successfully controlled @entity410 , combined @entity410 and @entity410 .

title: [Aggravation of @entity302 by @entity1092 in a @entity1 with cryptogenic localization-related XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['CPSs', 'seizures', 'complex partial seizures', 'myoclonic seizures']

entities_list: @entity198 :: ('MESH:D004660', 'Disease') :: ['encephalitis']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproate sodium']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy']

entities_list: @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: We report a paradoxical effect of @entity1092 ( @entity2052 ) observed in a 3-year-old @entity1 with cryptogenic localization-related @entity302 . On admission she experienced two types of @entity410 that were confirmed by ictal EEGs : @entity410 ( @entity410 ) originating from the left hemisphere and combined @entity410 that began with repetitive @entity410 immediately followed by a @entity38761 . These @entity410 did not possess asymmetrical features, but the ictal EEGs showed left-side dominant multiple spike-waves. The patent's interictal EEGs on admission showed left posterior temporal- parietal spikes during wakefulness and frequent diffuse spike-waves during sleep. In the process of introduction and increase in the dosage of @entity2052 , an aggravation of @entity302 discharges, especially a dramatic increase in diffuse spike-waves during sleep, was observed. In the same period of time, @entity410 not followed by @entity38761 newly appeared, and there was an increase in the frequency of @entity410 and combined @entity410 . Marked improvement of @entity302 discharges, namely the disappearance of diffuse discharges, and complete suppression of all types of @entity410 were achieved by the introduction of @entity2049 ( @entity2050 ) along with the withdrawal of @entity2052 . During the clinical course, the @entity1 did not display any signs or symptoms of @entity2052 @entity198 , @entity1445 of @entity2052 or metabolic aberration. The paradoxical effect of @entity2050 in localization-related @entity302 is well-known, yet in this case, @entity2052 displayed a similar paradoxical effect. Additionally, @entity2050 was efficacious in the suppression of secondary bilateral synchrony on EEG and also successfully controlled @entity410 , combined @entity410 and @entity410 .

title: [Aggravation of @entity302 by @entity1092 in a XXXX with cryptogenic localization-related @entity302 ].

answer: @entity1 :: (9606,Species) :: ['child']


abstract: Cervical connective tissue was obtained from non pregnant fertile @entity1 undergoing hysterectomy. Tissue specimens were mechanically chopped into 1 mm thick slices which were preincubated in Krebs-Ringer @entity3157 buffer containing @entity1421 or PGF2 alpha (300 ng/ml). After 60 min the slices were transferred into fresh buffer with the corresponding PG-concentration and 3H-labelled @entity1521 or @entity720 . Following incubation (60 min) the protein bound radioactivity was determined and related either to the dry weight or to the protein content of each slice. The two methods used did not show any qualitative differences. The experiments showed that PG:s had a marked effect on protein synthesis in the cervical tissue. During the follicular phase incubation with both types of PG:s was followed by a decreased incorporation indicating decreased net synthesis of collagen while there was an increased incorporation and hence increased synthesis in the luteal phase. There was no significant influence on the distribution of the model @entity535 @entity3209 -AIB in the presence of PG:s neither in the follicular nor in the luteal phase. The present data point to an acute effect of @entity1421 and PGF2 alpha on cervical collagen metabolism and indicate furthermore that the process is @entity134 hormone dependent. It is concluded that these substances may exert their effect by modulating the incorporation of @entity1522 into protein.

title: The regulatory influence of prostaglandins on protein synthesis in the XXXX non pregnant cervix.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline']

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Voiding synchronous cystosphincterometry with uroflowmetry was used in 16 @entity1 with traumatic cervical @entity1566 to evaluate bladder recovery. This method was shown to be reliable since the statistical analysis of the voiding responses showed the same values with repeated tests. A total of 14 @entity1 with such injuries recovered from shock in 6 weeks and 10 acquired mature @entity1494 with a synergic external sphincteric urethra approximately 13 weeks after @entity1566 . Bladders in @entity1 with cervical @entity1566 usually recover from a state of inactive detrusor to that of a mature contraction by way of immature small and/or sustained contractions. Pressure measurements revealed 7.1 plus or minus 3.7 cm. water in the empty bladder and 74 plus or minus 20.5 cm. water (43 plus or minus 13.3 seconds in duration) in the recovered @entity1494 . Resting pressure in the external sphincteric urethra was 70 plus or minus 25.3 cm. water. The dyssynergic sphincter coexists with immature sustained @entity1494 and it usually improves to the synergic state, according to the degree of maturity of @entity1494 . The bladder and external urethral sphincter recover independently and a synergic response develops even in cases of complete lesions. Thus, synergy can be accomplished by regulatory mechanisms at the sacral cord level. Surgical intervention should be postponed if the maturity of @entity1494 is not yet established. More precise objective information in the @entity1494 caused by cervical @entity1566 can be obtained when voiding synchronous cystosphincterometry with uroflowmetry is used.

title: Bladder recovery in @entity1 with traumatic cervical XXXX evaluated by voiding synchronous cystosphincterometry with uroflowmetry.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['dyssynergic bladder', 'bladder contraction']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'cord injury']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['cord injury']


abstract: Voiding synchronous cystosphincterometry with uroflowmetry was used in 16 @entity1 with traumatic cervical @entity1566 to evaluate bladder recovery. This method was shown to be reliable since the statistical analysis of the voiding responses showed the same values with repeated tests. A total of 14 @entity1 with such injuries recovered from shock in 6 weeks and 10 acquired mature @entity1494 with a synergic external sphincteric urethra approximately 13 weeks after @entity1566 . Bladders in @entity1 with cervical @entity1566 usually recover from a state of inactive detrusor to that of a mature contraction by way of immature small and/or sustained contractions. Pressure measurements revealed 7.1 plus or minus 3.7 cm. water in the empty bladder and 74 plus or minus 20.5 cm. water (43 plus or minus 13.3 seconds in duration) in the recovered @entity1494 . Resting pressure in the external sphincteric urethra was 70 plus or minus 25.3 cm. water. The dyssynergic sphincter coexists with immature sustained @entity1494 and it usually improves to the synergic state, according to the degree of maturity of @entity1494 . The bladder and external urethral sphincter recover independently and a synergic response develops even in cases of complete lesions. Thus, synergy can be accomplished by regulatory mechanisms at the sacral cord level. Surgical intervention should be postponed if the maturity of @entity1494 is not yet established. More precise objective information in the @entity1494 caused by cervical @entity1566 can be obtained when voiding synchronous cystosphincterometry with uroflowmetry is used.

title: Bladder recovery in XXXX with traumatic cervical @entity1566 evaluated by voiding synchronous cystosphincterometry with uroflowmetry.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Eleven pediatric @entity3153 @entity1 underwent surgery. Four had left, 5 right cardiac type and 2 had @entity3153 . Two @entity1 had 2 accessory conduction pathways (ACP). @entity4924 and secundum type @entity118 were the association @entity299 in one @entity1 each. Indications for surgery included repeated and/or long-lasting @entity4710 ( @entity4710 ), ineffective drug therapy, @entity712 due to frequent @entity591 , short effective refractory period of the ACP, and simultaneous surgery for associated @entity299 . Pre- and intra-operative examinations, including ECG, VCG, UCG, body surface mapping, intracavitary recording by catheter electrodes, computerized epicardial mapping, and endocardial mapping, were performed for the precise localization of the ACP. The surgical method was basically the same as is used for adults. Anterior median stermotomy was used primarily in right cardiac and right septal type and left anterior thoracotomy was used in 3 of 4 cases of the left cardiac type. Eight of 11 cases, two of which had 3 ACPs, were completely cured and in 3 there was evidence of postoperative pre-excitation. However, the @entity4710 attacks disappeared almost completely and drug therapy is not required at present.

title: Surgical treatment of the XXXX in @entity1 and @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4710 :: ('MESH:D013617', 'Disease') :: ['PSVT', 'paroxysmal supraventricular tachycardia']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure']

entities_list: @entity4924 :: ('MESH:D004437', 'Disease') :: ["Ebstein's anomaly"]

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital cardiac diseases']

entities_list: @entity118 :: ('MESH:D006344', 'Disease') :: ['atrial septal defect']

entities_list: @entity3153 :: ('MESH:D014927', 'Disease') :: ['Wolff-Parkinson-White (WPW) syndrome', 'right septal type WPW syndrome']

answer: @entity3153 :: (MESH:D014927,Disease) :: ['Wolff-Parkinson-White syndrome']


abstract: Eleven pediatric @entity3153 @entity1 underwent surgery. Four had left, 5 right cardiac type and 2 had @entity3153 . Two @entity1 had 2 accessory conduction pathways (ACP). @entity4924 and secundum type @entity118 were the association @entity299 in one @entity1 each. Indications for surgery included repeated and/or long-lasting @entity4710 ( @entity4710 ), ineffective drug therapy, @entity712 due to frequent @entity591 , short effective refractory period of the ACP, and simultaneous surgery for associated @entity299 . Pre- and intra-operative examinations, including ECG, VCG, UCG, body surface mapping, intracavitary recording by catheter electrodes, computerized epicardial mapping, and endocardial mapping, were performed for the precise localization of the ACP. The surgical method was basically the same as is used for adults. Anterior median stermotomy was used primarily in right cardiac and right septal type and left anterior thoracotomy was used in 3 of 4 cases of the left cardiac type. Eight of 11 cases, two of which had 3 ACPs, were completely cured and in 3 there was evidence of postoperative pre-excitation. However, the @entity4710 attacks disappeared almost completely and drug therapy is not required at present.

title: Surgical treatment of the @entity3153 in XXXX and @entity1 .

answer: @entity1 :: (9606,Species) :: ['infants']


abstract: Eleven pediatric @entity3153 @entity1 underwent surgery. Four had left, 5 right cardiac type and 2 had @entity3153 . Two @entity1 had 2 accessory conduction pathways (ACP). @entity4924 and secundum type @entity118 were the association @entity299 in one @entity1 each. Indications for surgery included repeated and/or long-lasting @entity4710 ( @entity4710 ), ineffective drug therapy, @entity712 due to frequent @entity591 , short effective refractory period of the ACP, and simultaneous surgery for associated @entity299 . Pre- and intra-operative examinations, including ECG, VCG, UCG, body surface mapping, intracavitary recording by catheter electrodes, computerized epicardial mapping, and endocardial mapping, were performed for the precise localization of the ACP. The surgical method was basically the same as is used for adults. Anterior median stermotomy was used primarily in right cardiac and right septal type and left anterior thoracotomy was used in 3 of 4 cases of the left cardiac type. Eight of 11 cases, two of which had 3 ACPs, were completely cured and in 3 there was evidence of postoperative pre-excitation. However, the @entity4710 attacks disappeared almost completely and drug therapy is not required at present.

title: Surgical treatment of the @entity3153 in @entity1 and XXXX .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: Subjective quality of life (QoL) and psychosocial functioning constitute important treatment outcomes in @entity161 . We aimed to investigate the relationship between them in @entity161 @entity1 living in the community. Symptom severity and insight were assessed with the Positive and Negative Syndrome Scale (PANSS) in 76 community @entity161 @entity1 . Social functioning was measured with the Portuguese version of @entity29784 ( @entity29784 ) scale, and subjective QoL was measured with the Portuguese version of the WHO Quality of Life Measure-Abbreviated Version (WHOQOL-Bref). The majority of @entity1 were single (78%) and unemployed/inactive (74%). Mean @entity29784 total score was 55.5, and mean scores on WHOQOL-Bref domains ranged from 54.1 to 63.0. Greater symptom severity and worse insight were significantly associated with worse functioning in all @entity29784 domains. Symptoms were more moderately correlated with QoL, with no significant correlations between QoL and positive symptoms and insight levels. Partial correlations controlling for symptom severity revealed no significant associations between social functioning and subjective QoL. Symptom severity may exert a greater influence on social functioning than on subjective QoL; however, social functioning was not associated with subjective QoL. The results suggest these constructs might be independent and should be assessed separately. A broader research approach, with increased attention to social and psychological factors, may help identify treatment targets to improve @entity161 @entity1 ' social functioning and QoL.

title: Is personal and social functioning associated with subjective quality of life in XXXX @entity1 living in the community?

entities_list: @entity29784 :: ('140683', 'Gene') :: ['PSP', 'Personal and Social Performance']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: Subjective quality of life (QoL) and psychosocial functioning constitute important treatment outcomes in @entity161 . We aimed to investigate the relationship between them in @entity161 @entity1 living in the community. Symptom severity and insight were assessed with the Positive and Negative Syndrome Scale (PANSS) in 76 community @entity161 @entity1 . Social functioning was measured with the Portuguese version of @entity29784 ( @entity29784 ) scale, and subjective QoL was measured with the Portuguese version of the WHO Quality of Life Measure-Abbreviated Version (WHOQOL-Bref). The majority of @entity1 were single (78%) and unemployed/inactive (74%). Mean @entity29784 total score was 55.5, and mean scores on WHOQOL-Bref domains ranged from 54.1 to 63.0. Greater symptom severity and worse insight were significantly associated with worse functioning in all @entity29784 domains. Symptoms were more moderately correlated with QoL, with no significant correlations between QoL and positive symptoms and insight levels. Partial correlations controlling for symptom severity revealed no significant associations between social functioning and subjective QoL. Symptom severity may exert a greater influence on social functioning than on subjective QoL; however, social functioning was not associated with subjective QoL. The results suggest these constructs might be independent and should be assessed separately. A broader research approach, with increased attention to social and psychological factors, may help identify treatment targets to improve @entity161 @entity1 ' social functioning and QoL.

title: Is personal and social functioning associated with subjective quality of life in @entity161 XXXX living in the community?

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: Our aim was to determine the most effective surgical procedure for treatment of @entity66 , by comparing different surgical techniques. METHODS: A total of 354 @entity1 who underwent operation for @entity66 were enrolled in this prospective study. The data included @entity1 's demographic characteristics, age, gender, body mass index, occupation, smoking, concomitant diseases, surgeon's experience, wound-healing problems (wound separation and @entity281 ), time to return to work, and development of recurrence. RESULTS: Of the 354 @entity1 , total excision   +   primary closure was performed in 133 (37.6%), D-flap in 101 (28.5%), Karydakis technique in 74 (20.9%), and Limberg flap surgery in 46 (13%). The male/female ratio was 8.5:1, which is a statistically significant difference (p   <   0.05). The average follow-up period was 37  months (range, 12-97  months); during this period, wound-healing problems were observed in 70 (19.7%) @entity1 , and 34 (9.6%) @entity1 developed recurrence. There was no difference in the rate of recurrence of @entity66 between procedures done by trainees and staff surgeons. Recurrence rates were similar for all four treatment methods (7.5-13.5%). Wound-healing problems were higher for D-flap than for other methods (p   =   0.027). The average time to return to work with the D-flap method was longer than that for the other methods (p   <   0.01). Recurrence increased 14.44-fold following the development of @entity2737 . Higher recurrence rates were also noted in @entity28 @entity1 (8.10-fold) and in females (6.72-fold). CONCLUSIONS: Despite the increasing volume of data on the treatment of @entity66 , the optimal treatment has yet to be established.

title: Which surgical procedure offers the best treatment for XXXX ?

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['pilonidal disease', 'pilonidial disease']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['wound infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity66 :: (MESH:D004194,Disease) :: ['pilonidal disease']


abstract: OBJECTIVE: @entity712 is an important cause of @entity204 in @entity1 with @entity309 ( @entity309 ). Evidence suggests that immune mechanisms contribute to @entity296 and @entity82 , leading to @entity1002 ( @entity1002 ). The purpose of this study was to identify a signature of @entity1002 in @entity1 with @entity309 by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo. METHODS: @entity309 @entity1 (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild @entity1002 , or moderate-to-severe @entity1002 . The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. @entity2357 models were used to test for associations between a multicytokine immune response score and @entity1002 , after adjusting for clinical covariates. RESULTS: An 11-cytokine profile effectively differentiated @entity1 with moderate-to-severe @entity1002 from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe @entity1002 (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum @entity650 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other @entity309 characteristics and @entity1002 risk factors. CONCLUSION: The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced @entity296 in @entity1 with @entity309 . The unique information added by the immune response score concerning the likelihood of @entity1002 warrants future longitudinal studies of its value in predicting @entity5122 in myocardial function.

title: A signature of aberrant immune responsiveness identifies XXXX in @entity309 .

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury', 'myocardial dysfunction']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity5122 :: ('MESH:C565430', 'Disease') :: ['future deterioration']

entities_list: @entity2357 :: ('MESH:C537770', 'Disease') :: ['Logistic regression']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['LVDD', 'left ventricular diastolic dysfunction']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial dysfunction']


abstract: OBJECTIVE: @entity712 is an important cause of @entity204 in @entity1 with @entity309 ( @entity309 ). Evidence suggests that immune mechanisms contribute to @entity296 and @entity82 , leading to @entity1002 ( @entity1002 ). The purpose of this study was to identify a signature of @entity1002 in @entity1 with @entity309 by analyzing the responsiveness of the innate and adaptive immune systems to stimulation ex vivo. METHODS: @entity309 @entity1 (n=212) enrolled prospectively in a population-based cohort underwent echocardiography, and LV function was classified as normal, mild @entity1002 , or moderate-to-severe @entity1002 . The release of 17 cytokines by blood mononuclear cells in response to stimulation with a panel of 7 stimuli or in media alone was analyzed using multiplex immunoassays. @entity2357 models were used to test for associations between a multicytokine immune response score and @entity1002 , after adjusting for clinical covariates. RESULTS: An 11-cytokine profile effectively differentiated @entity1 with moderate-to-severe @entity1002 from those with normal LV function. An immune response score (range 0-100) was strongly associated with moderate-to-severe @entity1002 (odds ratio per 10 units 1.5 [95% confidence interval 1.2-2.1]) after adjusting for serum @entity650 levels, brain natriuretic peptide values, and glucocorticoid use, as well as other @entity309 characteristics and @entity1002 risk factors. CONCLUSION: The major finding of this study was that aberrant systemic immune responsiveness is associated with advanced @entity296 in @entity1 with @entity309 . The unique information added by the immune response score concerning the likelihood of @entity1002 warrants future longitudinal studies of its value in predicting @entity5122 in myocardial function.

title: A signature of aberrant immune responsiveness identifies @entity296 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: BACKGROUND: @entity189 is a rare, locally aggressive @entity5 most commonly occurring on the face. Minimal data are available regarding the role of @entity1161 ( @entity1161 ). METHODS: Cases treated with @entity1161 from 2 comprehensive @entity5 centers are reviewed along with a review of the literature. RESULTS: Three @entity1 with @entity189 of the face were treated with curative intent. One @entity1 received @entity1161 as monotherapy. Two @entity1 received postoperative @entity1161 (PORT). The @entity1 receiving @entity1161 as monotherapy experienced excellent clinical regression, had an in-field recurrence at 48-month follow-up, and is now without evidence of disease after reirradiation. Both @entity1 receiving PORT are without evidence of disease. CONCLUSION: PORT may improve local control in @entity1 with @entity189 , and its use should be considered in @entity1 with high-risk features for local recurrence. @entity1161 as monotherapy should be considered when poor cosmetic outcome can be anticipated via standard surgical treatments.

title: XXXX of the face treated with @entity1161 : a case report and review of the literature.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'neoplasm']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Microcystic adnexal carcinoma', 'microcystic adnexal carcinoma']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT']

answer: @entity189 :: (MESH:D002277,Disease) :: ['Microcystic adnexal carcinoma']


abstract: BACKGROUND: @entity189 is a rare, locally aggressive @entity5 most commonly occurring on the face. Minimal data are available regarding the role of @entity1161 ( @entity1161 ). METHODS: Cases treated with @entity1161 from 2 comprehensive @entity5 centers are reviewed along with a review of the literature. RESULTS: Three @entity1 with @entity189 of the face were treated with curative intent. One @entity1 received @entity1161 as monotherapy. Two @entity1 received postoperative @entity1161 (PORT). The @entity1 receiving @entity1161 as monotherapy experienced excellent clinical regression, had an in-field recurrence at 48-month follow-up, and is now without evidence of disease after reirradiation. Both @entity1 receiving PORT are without evidence of disease. CONCLUSION: PORT may improve local control in @entity1 with @entity189 , and its use should be considered in @entity1 with high-risk features for local recurrence. @entity1161 as monotherapy should be considered when poor cosmetic outcome can be anticipated via standard surgical treatments.

title: @entity189 of the face treated with XXXX : a case report and review of the literature.

answer: @entity1161 :: (MESH:D011832,Disease) :: ['radiation therapy']


abstract: We report a 78-year-old @entity1 who had episodes of @entity159 ( @entity159 ) with @entity1296 . At 75 years of age, she had first @entity410 , but was not well examined. At 78 years of age, she had brief myoclonic jerks of her arms, soon after awakening, in May. She suffered from strong @entity1296 and was admitted in our hospital at the end of June. The symptoms regressed with bed rest in few days and she was discharged. However, she was admitted again with @entity1296 in the middle of July. There were no myoclonic jerks of her arms or legs and she could converse and interact normally, but was slightly disoriented (JCS: 2). Blood test, Cerebrospinal fluid analyses and brain MRI were normal. An EEG showed frequent intermittent generalized multiple spikes and slow wave complexes and a 3-4 Hz generalized spike and slow wave complexes every 2-4 seconds during whole 20 minutes record. Intravenous injection of 5 mg @entity3175 terminated status immediately. Thereafter, she was treated with @entity1092 (400 mg/day). Her symptoms improved, and interictal @entity302 discharges extremely decreased. Late-onset @entity159 of @entity6191 is rare. We discussed this case as an important case for diagnosis of @entity159 with subtle symptom of @entity1296 .

title: [A late-onset case of XXXX of @entity6191 ].

entities_list: @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['sodium valproate']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic']

entities_list: @entity6191 :: ('MESH:D004829', 'Disease') :: ['generalized epilepsy']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['nonconvulsive status epilepticus', 'NCSE']

answer: @entity159 :: (MESH:D013226,Disease) :: ['nonconvulsive status epilepticus']


abstract: We report a 78-year-old @entity1 who had episodes of @entity159 ( @entity159 ) with @entity1296 . At 75 years of age, she had first @entity410 , but was not well examined. At 78 years of age, she had brief myoclonic jerks of her arms, soon after awakening, in May. She suffered from strong @entity1296 and was admitted in our hospital at the end of June. The symptoms regressed with bed rest in few days and she was discharged. However, she was admitted again with @entity1296 in the middle of July. There were no myoclonic jerks of her arms or legs and she could converse and interact normally, but was slightly disoriented (JCS: 2). Blood test, Cerebrospinal fluid analyses and brain MRI were normal. An EEG showed frequent intermittent generalized multiple spikes and slow wave complexes and a 3-4 Hz generalized spike and slow wave complexes every 2-4 seconds during whole 20 minutes record. Intravenous injection of 5 mg @entity3175 terminated status immediately. Thereafter, she was treated with @entity1092 (400 mg/day). Her symptoms improved, and interictal @entity302 discharges extremely decreased. Late-onset @entity159 of @entity6191 is rare. We discussed this case as an important case for diagnosis of @entity159 with subtle symptom of @entity1296 .

title: [A late-onset case of @entity159 of XXXX ].

answer: @entity6191 :: (MESH:D004829,Disease) :: ['generalized epilepsy']


abstract: OBJECTIVE: The objective of this study is to explore the sensitivity to intermodal asynchrony in audiovisual speech with moderate to severe @entity1274 . Based on previous studies, two opposing expectations were an increase in sensitivity, as @entity393 listeners heavily rely on lipreading in daily life, and a reduction in sensitivity, as @entity393 listeners tend to be elderly and advanced age could potentially impair audiovisual integration. DESIGN: Adults with normal (N = 11, ages between 23 and 50 yrs) and impaired hearing (N = 11, ages between 54 and 81 yrs, the pure-tone average between 42 and 67 dB @entity1733 ) participated in two experiments. In the first experiment, the synchrony judgments were recorded for varying intermodal time differences in audiovisual sentence recordings. In the second experiment, the intelligibility of audiovisual and audio-only speech was measured in speech-shaped noise, and correlations were explored between the synchrony window and intelligibility scores for individual listeners. RESULTS: Similar to previous studies, a sensitivity window on the order of a few hundred milliseconds was observed with all listeners. The average window shapes did not differ between normal-hearing and @entity393 groups; however, there was large individual variability. Individual windows were quantified by Gaussian curve fitting. Point of subjective simultaneity, a measure of window peak shift from the actual synchrony point, and full-width at half-maximum, a measure of window duration, were not correlated with @entity1 's age or the degree of @entity393 . Points of subjective simultaneity were also not correlated with speech intelligibility scores. A moderate negative correlation that was significant at most conditions was observed between the full-width at half-maximum values and intelligibility scores. CONCLUSIONS: Contrary to either expectation per se, there was no indication of an effect of @entity393 or age on the sensitivity to intermodal asynchrony in audiovisual speech. It is possible that the negative effects of aging were balanced with the positive effects of increased sensitivity due to reliance on visual cues with @entity393 . The listeners, normal hearing or @entity393 , who were more sensitive to asynchrony (with narrower synchrony windows) tended to understand speech in noise better, with both audio-only and audiovisual speech. The practical implication of the results is that delays in audio or video signals of communication systems would affect @entity393 listeners in a manner similar to normal-hearing listeners, and due to the importance of visual cues for the @entity393 listeners, special attention should be given to limit these delays.

title: Audiovisual asynchrony detection and speech intelligibility in noise with moderate to severe XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participant']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss', 'hearing impaired', 'hearing impairment', 'hearing-impaired']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss']

answer: @entity1274 :: (MESH:D006319,Disease) :: ['sensorineural hearing impairment']


abstract: BACKGROUND: @entity510 is widely used for cesarean section due to the rapid induction, the complete @entity1337 , the low failure rate and the prevention of @entity1174 . The addition of intrathecal opioids to local anesthetics seems to improve the quality of @entity1337 _ prolong the duration of @entity1337 . Therefore we compared the effects of @entity3575 20   g and @entity681 2.5   g, which were added to intrathecal hyperbaric @entity1341 . METHODS: SEVENTY TWO HEALTHY TERM PARTURIENTS WERE RANDOMLY DIVIDED INTO THREE GROUPS: Group C (control), Group F ( @entity3575 20   g) and Group S ( @entity681 2.5   g). In every group, 0.5% heavy @entity1341 was added according to the adjusted dose regimen by Harten et al. We observed the maximal level of the sensory block and motor block, the quality of intraoperative @entity1337 , the duration of effective @entity1337 and the side effects. RESULTS: There were significant differences between the control and the @entity3575 20   g and @entity681 2.5   g groups for the degree of @entity121 , the quality of intraoperative @entity1337 , the maximal sedation level and the duration of effective @entity1337 . The frequencies of side effects such as @entity390 and @entity111 in the opioid groups were higher than those in the control group. But there were no differences between @entity3575 20   g and @entity681 2.5   g for the frequencies of @entity390 and @entity111 . CONCLUSIONS: The addition of @entity3575 20   g or @entity681 2.5   g for spinal anesthesia provides adequate intraoperative @entity1337 without significant adverse effects on the mother and neonate.

title: Comparison of @entity3575 and @entity681 added to 0.5% hyperbaric XXXX for spinal anesthesia in patients undergoing cesarean section.

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle relaxation']

entities_list: @entity681 :: ('MESH:D017409', 'Chemical') :: ['sufentanil']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['Subarachnoid block']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritis']

entities_list: @entity1174 :: ('MESH:D011015', 'Disease') :: ['aspiration pneumonia']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

answer: @entity1341 :: (MESH:D002045,Chemical) :: ['bupivacaine']


abstract: BACKGROUND: @entity510 is widely used for cesarean section due to the rapid induction, the complete @entity1337 , the low failure rate and the prevention of @entity1174 . The addition of intrathecal opioids to local anesthetics seems to improve the quality of @entity1337 _ prolong the duration of @entity1337 . Therefore we compared the effects of @entity3575 20   g and @entity681 2.5   g, which were added to intrathecal hyperbaric @entity1341 . METHODS: SEVENTY TWO HEALTHY TERM PARTURIENTS WERE RANDOMLY DIVIDED INTO THREE GROUPS: Group C (control), Group F ( @entity3575 20   g) and Group S ( @entity681 2.5   g). In every group, 0.5% heavy @entity1341 was added according to the adjusted dose regimen by Harten et al. We observed the maximal level of the sensory block and motor block, the quality of intraoperative @entity1337 , the duration of effective @entity1337 and the side effects. RESULTS: There were significant differences between the control and the @entity3575 20   g and @entity681 2.5   g groups for the degree of @entity121 , the quality of intraoperative @entity1337 , the maximal sedation level and the duration of effective @entity1337 . The frequencies of side effects such as @entity390 and @entity111 in the opioid groups were higher than those in the control group. But there were no differences between @entity3575 20   g and @entity681 2.5   g for the frequencies of @entity390 and @entity111 . CONCLUSIONS: The addition of @entity3575 20   g or @entity681 2.5   g for spinal anesthesia provides adequate intraoperative @entity1337 without significant adverse effects on the mother and neonate.

title: Comparison of @entity3575 and XXXX added to 0.5% hyperbaric @entity1341 for spinal anesthesia in patients undergoing cesarean section.

answer: @entity681 :: (MESH:D017409,Chemical) :: ['sufentanil']


abstract: BACKGROUND: @entity510 is widely used for cesarean section due to the rapid induction, the complete @entity1337 , the low failure rate and the prevention of @entity1174 . The addition of intrathecal opioids to local anesthetics seems to improve the quality of @entity1337 _ prolong the duration of @entity1337 . Therefore we compared the effects of @entity3575 20   g and @entity681 2.5   g, which were added to intrathecal hyperbaric @entity1341 . METHODS: SEVENTY TWO HEALTHY TERM PARTURIENTS WERE RANDOMLY DIVIDED INTO THREE GROUPS: Group C (control), Group F ( @entity3575 20   g) and Group S ( @entity681 2.5   g). In every group, 0.5% heavy @entity1341 was added according to the adjusted dose regimen by Harten et al. We observed the maximal level of the sensory block and motor block, the quality of intraoperative @entity1337 , the duration of effective @entity1337 and the side effects. RESULTS: There were significant differences between the control and the @entity3575 20   g and @entity681 2.5   g groups for the degree of @entity121 , the quality of intraoperative @entity1337 , the maximal sedation level and the duration of effective @entity1337 . The frequencies of side effects such as @entity390 and @entity111 in the opioid groups were higher than those in the control group. But there were no differences between @entity3575 20   g and @entity681 2.5   g for the frequencies of @entity390 and @entity111 . CONCLUSIONS: The addition of @entity3575 20   g or @entity681 2.5   g for spinal anesthesia provides adequate intraoperative @entity1337 without significant adverse effects on the mother and neonate.

title: Comparison of XXXX and @entity681 added to 0.5% hyperbaric @entity1341 for spinal anesthesia in patients undergoing cesarean section.

answer: @entity3575 :: (MESH:D005283,Chemical) :: ['fentanyl']


abstract: BACKGROUND: Spasticity is a common @entity16 with adverse effects on the @entity1 's function. Conservative management is unsuccessful in a significant proportion of @entity1 and neurosurgical intervention should be considered. The mainstay of surgical treatment of @entity508 is selective posterior rhizotomy, i.e., section of sensory nerve roots of the cauda equina. OBJECTIVE: To report our experience with selective posterior rhizotomy in the treatment of @entity508 . METHODS: We retrospectively reviewed our experience in 154 @entity1 who underwent @entity29552 during 30 years. The indication for surgery was @entity508 that significantly hindered the @entity1 's function or care and was resistant to conservative treatment. All @entity1 were evaluated for @entity508 in the lower and upper limbs, the presence or absence of @entity158 , and sphincter disturbances. The decision as to which roots to be sectioned, and to what extent, was based mainly on clinical muscle testing. RESULTS: Reduction of @entity508 in the lower limbs was obtained in every case, with improvement in movements in 86% of cases. Painful @entity2473 were alleviated in 80% of cases. @entity1494 was observed in 42%. A minority of the @entity1 also showed improvement in speech and cognitive performance. There was no perioperative mortality or major complications. CONCLUSION: @entity29552 is a safe and effective method for the treatment of @entity508 with long-lasting beneficial effects. We suggest that this method be considered more frequently for @entity1 with @entity508 that interferes with their quality of life.

title: Surgical treatment of XXXX by selective posterior rhizotomy: 30 years experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['Amelioration of neurogenic bladder']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic disorder']

entities_list: @entity508 :: ('MESH:D009128', 'Disease') :: ['spasticity']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['painful spasms']

answer: @entity508 :: (MESH:D009128,Disease) :: ['spasticity']


abstract: BACKGROUND: The histologic status of axillary lymph nodes is one of the most important prognostic factors in @entity0 and influences the management of these @entity1 . Axillary lymph node dissection was traditionally performed in all @entity1 to obtain this information but this procedure carries a considerable rate of complications. Recently, sentinel lymph node biopsy has emerged as an accurate and minimally invasive tool for predicting the axillary nodal status and has become the standard of care in selected @entity1 with @entity0 . OBJECTIVE: To examine the accuracy of @entity4298 biopsies performed by surgical residents during surgical resident training. METHODS: This prospective, randomized controlled study included 100 consecutive @entity1 with clinically early @entity0 (T1-T2, N0, M0). Lymphatic mapping was performed using radiotracers, blue dye, or both. Formal axillary lymph node dissection completed the operations in all @entity1 . All operations were performed by surgical residents under the supervision of senior surgeons. RESULTS: The overall rate of identification of sentinel lymph nodes was 92%. The accuracy of @entity4298 biopsy in reflecting the axillary nodal status was 96% with a false negative rate of 5.7%. CONCLUSIONS: Sentinel lymph node biopsy is an accurate method for the evaluation and staging of regional lymph nodes in @entity0 @entity1 . A dedicated instruction program for surgical residents may increase the standard of care and lead to highly trained surgeons in the management of early @entity0 .

title: Sentinel lymph node biopsy in early XXXX : the first 100 cases performed in a teaching institute.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: Intestinal parasitic infections (IPIs) have a worldwide distribution and have been identified as one of the most significant causes of illnesses and diseases among the disadvantaged population. In Malaysia, IPIs still persist in some rural areas, and this study was conducted to determine the current epidemiological status and to identify risk factors associated with IPIs among communities residing in @entity739 . METHODS/FINDINGS: A total of 716 @entity1 from 8 villages were involved, comprising those from 1 to 83 years old, 550 (76.8%) @entity1 aged  <=12 years and 166 (23.2%) aged >= 13 years, and 304 (42.5%) male and 412 (57.5%) female. The overall prevalence of IPIs was high (73.2%). Soil-transmitted helminth (STH) infections (73.2%) were significantly more common compared to @entity281 (21.4%) (p<0.001). The prevalence of IPIs showed an age dependency relationship, with significantly higher rates observed among those aged  <=12 years. Multivariate analysis demonstrated that @entity1 aged  <=12 years (OR=2.23; 95% CI=1.45-3.45), low household income (OR=4.93; 95% CI=3.15-7.73), using untreated water supply (OR=2.08; 95% CI=1.36-3.21), and indiscriminate defecation (OR=5.01; 95% CI=3.30-7.62) were identified as significant predictors of IPIs among these communities. CONCLUSION: Essentially, these findings highlighted that IPIs are highly prevalent among the poor rural communities in @entity739 . Poverty and low socioeconomic with poor environmental sanitation were indicated as important predictors of IPIs. Effective poverty reduction programmes, promotion of deworming, and mass campaigns to heighten awareness on health and hygiene are urgently needed to reduce IPIs.

title: Prevalence and risk factors of intestinal parasitism in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity739 :: ('MESH:D013036', 'Disease') :: ['West Malaysia', 'rural and remote areas of West Malaysia']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['protozoa infections']

answer: @entity739 :: (MESH:D013036,Disease) :: ['rural and remote West Malaysia']


abstract: AIMS: Sonoelastography (SEG) is a noninvasive ultrasound (US) method able to differentiate tissues according to their stiffness. Our objective was to establish whether transrectal (TR) SEG may improve @entity263 detection, alone or associated with other US methods. @entity1 AND METHODS: We analyzed the data of 65 @entity1 , mean age 68 years (49 - 81 years), examined March 2009-September 2010. The @entity1 had at least one of the following malignancy suspicion criteria: PSA > 4 ng /ml (minimum 2 determinations), nodule(s) at digital rectal examination (DRE +) or previous gray scale TRUS positive appearance. All @entity1 underwent TRUS, Doppler-US and SEG in the same session, followed by systematic prostate biopsies (6-12 cores). Histopathology and imaging findings were correlated. RESULTS: Twenty-eight out of 65 @entity1 (43%) were diagnosed with @entity263 . Overall, SEG had a sensitivity of 67.85%, specificity 62.16%, positive predictive value 57.57% and negative predictive value 71.85%. However, SEG diagnostic reliability appeared to be higher for subgroups of @entity1 having PSA >10 ng / ml, lower number of fragments collected by @entity5664 (6 vs. 10-12 cores) and age > 70 years. CONCLUSION: SEG appears to be useful in the diagnosis of @entity263 as it may increase the diagnosis accuracy in specific target groups.

title: Real-time sonoelastography in the diagnosis of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: OBJECTIVE: To review the safety and efficacy of the very-low-dose combination of @entity4687 2 mg and @entity7486 0.625 mg ( @entity5394 /Ind0.625) in essential @entity101 , in relation to blood pressure control and target-organ damage. STUDY SELECTION: We included in this review several double-blind, randomized studies in @entity101 @entity1 , including five main studies from the European registration file and two clinical trials on regression of target-organ damage [large artery stiffness: the Preterax in Regression of Arterial Stiffness in a Controlled Double-Blind Study (REASON); microalbuminuria in @entity1 with type 2 @entity6 : the Preterax in Albuminuria Regression (PREMIER) study]. MAIN OUTCOME MEASURES: Systolic ( @entity13519 ) and @entity551 measured at trough with a @entity349 sphygmomanometer, an automatic device (OMRON), and 24-h ambulatory blood pressure measurements (ABPM). Arterial stiffness, assessed from pulse wave velocity measurement and augmentation index (REASON study). Microalbuminuria (PREMIER study). RESULTS: The @entity5394 /Ind0.625 combination was selected from the dose-finding studies. Twelve weeks after the @entity1 were assigned to study groups, the reductions in @entity13519 , measured with an OMRON device, were 12.3 +/- 15.0 mmHg with @entity5394 /Ind0.625, 8.0 +/- 16.5 mmHg with @entity4687 2 mg (P = 0.001), 9.4 +/- 14.3 mmHg with @entity7486 0.625 mg (P = 0.023) and 2.1 +/- 16.8 mmHg with placebo (P < 0.001) (mean +/- SD; all P values are for comparisons with @entity5394 /Ind0.625). The reductions in DBP were 6.8 +/- 9.2 mmHg, 5.0 +/- 9.5 mmHg (P = 0.02), 4.7 +/- 8.2 mmHg (P = 0.004) and 2.4 +/- 9.6 mmHg (P < 0.001) in the @entity5394 /Ind0.625, @entity4687 2 mg, @entity7486 0.625 mg and placebo groups, respectively. During the long-term study, among 235 @entity1 who achieved initial blood pressure normalization with the fixed combination, 79.8% sustained their normalized status over 1 year, with no significant difference regarding safety criteria. During the REASON study, Per/Ind reduced pulse wave velocity to a similar extent as @entity2165 , and augmentation index to a greater extent. During the PREMIER study, Per/Ind reduced microalbuminuria to a greater extent than did @entity4688 . CONCLUSIONS: The proven efficacy on blood pressure and regression of target-organ damage with a good safety profile confirm that the new fixed-low-dose combination @entity5394 /Ind0.625 is a valuable option in the first-line treatment of @entity101 .

title: Very-low-dose combination of XXXX and @entity7486 : efficacy on blood pressure and target-organ damage.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity7486 :: ('MESH:D007190', 'Chemical') :: ['indapamide']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity349 :: ('MESH:D008628', 'Chemical') :: ['mercury']

entities_list: @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['diastolic (DBP) blood pressures']

entities_list: @entity4687 :: ('MESH:D020913', 'Chemical') :: ['perindopril']

answer: @entity4687 :: (MESH:D020913,Chemical) :: ['perindopril']


abstract: OBJECTIVE: To review the safety and efficacy of the very-low-dose combination of @entity4687 2 mg and @entity7486 0.625 mg ( @entity5394 /Ind0.625) in essential @entity101 , in relation to blood pressure control and target-organ damage. STUDY SELECTION: We included in this review several double-blind, randomized studies in @entity101 @entity1 , including five main studies from the European registration file and two clinical trials on regression of target-organ damage [large artery stiffness: the Preterax in Regression of Arterial Stiffness in a Controlled Double-Blind Study (REASON); microalbuminuria in @entity1 with type 2 @entity6 : the Preterax in Albuminuria Regression (PREMIER) study]. MAIN OUTCOME MEASURES: Systolic ( @entity13519 ) and @entity551 measured at trough with a @entity349 sphygmomanometer, an automatic device (OMRON), and 24-h ambulatory blood pressure measurements (ABPM). Arterial stiffness, assessed from pulse wave velocity measurement and augmentation index (REASON study). Microalbuminuria (PREMIER study). RESULTS: The @entity5394 /Ind0.625 combination was selected from the dose-finding studies. Twelve weeks after the @entity1 were assigned to study groups, the reductions in @entity13519 , measured with an OMRON device, were 12.3 +/- 15.0 mmHg with @entity5394 /Ind0.625, 8.0 +/- 16.5 mmHg with @entity4687 2 mg (P = 0.001), 9.4 +/- 14.3 mmHg with @entity7486 0.625 mg (P = 0.023) and 2.1 +/- 16.8 mmHg with placebo (P < 0.001) (mean +/- SD; all P values are for comparisons with @entity5394 /Ind0.625). The reductions in DBP were 6.8 +/- 9.2 mmHg, 5.0 +/- 9.5 mmHg (P = 0.02), 4.7 +/- 8.2 mmHg (P = 0.004) and 2.4 +/- 9.6 mmHg (P < 0.001) in the @entity5394 /Ind0.625, @entity4687 2 mg, @entity7486 0.625 mg and placebo groups, respectively. During the long-term study, among 235 @entity1 who achieved initial blood pressure normalization with the fixed combination, 79.8% sustained their normalized status over 1 year, with no significant difference regarding safety criteria. During the REASON study, Per/Ind reduced pulse wave velocity to a similar extent as @entity2165 , and augmentation index to a greater extent. During the PREMIER study, Per/Ind reduced microalbuminuria to a greater extent than did @entity4688 . CONCLUSIONS: The proven efficacy on blood pressure and regression of target-organ damage with a good safety profile confirm that the new fixed-low-dose combination @entity5394 /Ind0.625 is a valuable option in the first-line treatment of @entity101 .

title: Very-low-dose combination of @entity4687 and XXXX : efficacy on blood pressure and target-organ damage.

answer: @entity7486 :: (MESH:D007190,Chemical) :: ['indapamide']


abstract: BACKGROUND: Our purpose was to determine the anatomical outcome following small gauge vitrectomy for @entity1713 ( @entity1713 ) operated by vitreoretinal fellows. METHODS: We undertook a retrospective review of adult @entity1 presenting with an acute @entity1713 treated with small gauge vitrectomy where the operating surgeon was either a vitreoretinal fellow or consultant surgeon. The @entity1 's demographics were recorded as well as relevant clinical findings. The end point was determined to be the anatomical outcome and number of surgeries. RESULTS: Two hundred and twelve eyes were included in this study. The age range was 21-90 years, with approximately one third of the @entity1 being female. The macula was attached in 53% at presentation, and 65% of the eyes were phakic. Primary re-attachment with a single operation was achieved in 75% of cases, and final re-attachment rate was 92%. Mean presenting visual acuity was LogMAR 1.07 (SD 1.09) and final visual acuity was LogMAR 0.63 (SD 0.85). We found no association between final anatomical success and experience of the surgeon (p = 0.6). CONCLUSION: We found that acute @entity1713 treated by vitreoretinal fellows using small gauge vitrectomy did not place the @entity1 at any discernable disadvantage.

title: Vitreoretinal fellow surgical outcome of small gauge pars plana vitrectomy for XXXX .

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['RRD', 'acute rhegmatogenous retinal detachment']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity1713 :: (MESH:D012163,Disease) :: ['acute rhegmatogenous retinal detachment']


abstract: OBJECTIVES: Knowledge of @entity988 research findings is critical for healthcare professionals who treat addicted @entity1 . However, there is little information available about the instructional effectiveness of lecture-slide presentations in changing knowledge vs. beliefs of such professionals. DESIGN: A modified Solomon four-group experimental design was used to assess the instructional effectiveness (knowledge gain vs. belief changes) of three-hour @entity988 science workshops presented to health-care professionals by neurobiologically-trained academic researchers. Effectiveness of the workshops was assessed by a 28-item questionnaire on @entity1 versus control group knowledge/beliefs on @entity988 . Six-month follow-up questionnaires measured "retention" of knowledge and belief changes. RESULTS: The workshop @entity1 showed significant knowledge gain and belief changes, whereas the two control groups showed no change in knowledge or beliefs. After six months, knowledge gains decreased, but were still higher than pre-test scores. In contrast, belief changes on three subscales persisted over six months in 40 to 52 percent of the subjects. CONCLUSIONS: These results illustrate a successful continuing education model by which academic researchers who are skilled teachers present a three-hour lecture-slide workshop with extensive question-and-answer sessions on addictions. We conclude that motivated health-care professionals can experience important knowledge gains and belief changes by participating in such workshops. In contrast to the transient retention of knowledge, belief changes persisted surprisingly well for at least six months in about half the subjects. These results suggest that long-term changes in the professional orientation of these health-care workers are possible.

title: Effectiveness of XXXX science presentations to treatment professionals, using a modified Solomon study design.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'participant', 'participants']

entities_list: @entity988 :: ('MESH:D000437', 'Disease') :: ['addiction']

answer: @entity988 :: (MESH:D000437,Disease) :: ['addiction']


abstract: BACKGROUND: @entity1904 (PCT) is an established biomarker for the diagnosis of @entity295 . Evidence is growing that PCT concentration correlates with the extent of @entity731 and prognosis in @entity1 with @entity453 ( @entity453 ). METHODS AND RESULTS: A total of 2,131 @entity1 with @entity453 were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 @entity1 and non-fatal @entity583 in 85 @entity1 . Median and quartile 1 and 3 are reported for PCT concentration. @entity1 who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. @entity1 with @entity1187 had increased concentrations of PCT in relation to @entity1 with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to @entity65 (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for @entity1851 ( @entity1851 ), PCT did not provide additional prognostic information. CONCLUSIONS: PCT is associated with future cardiovascular mortality in @entity1 with @entity453 , but PCT is not superior to @entity1851 for prediction of outcome.

title: Association of serum XXXX with cardiovascular prognosis in @entity453 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity1904 :: ('MESH:C029100', 'Chemical') :: ['Procalcitonin']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular events']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity1904 :: (MESH:C029100,Chemical) :: ['procalcitonin']


abstract: BACKGROUND: @entity1904 (PCT) is an established biomarker for the diagnosis of @entity295 . Evidence is growing that PCT concentration correlates with the extent of @entity731 and prognosis in @entity1 with @entity453 ( @entity453 ). METHODS AND RESULTS: A total of 2,131 @entity1 with @entity453 were followed up for a median of 3.6 years. During follow-up, death from cardiovascular causes was registered in 95 @entity1 and non-fatal @entity583 in 85 @entity1 . Median and quartile 1 and 3 are reported for PCT concentration. @entity1 who died of cardiovascular causes had higher PCT concentrations [0.021 (0.012/0.036) ng/ml vs. 0.015 (0.010/0.023) ng/ml; P<0.0001]. @entity1 with @entity1187 had increased concentrations of PCT in relation to @entity1 with stable angina [0.016 (0.011/0.027) ng/ml vs. 0.014 (0.009/0.014) ng/ml; P for trend <0.0001]. PCT concentration across quartiles was associated with the event rate (P=0.026; log-rank test) and mortality (P=0.00018). On Cox regression analysis, elevated PCT concentration was related to cardiovascular mortality [hazard ratio (HR), 1.34; 95% confidence interval (CI): 1.08-1.65, P=0.0070], but not to @entity65 (HR, 1.09; 95%CI: 0.93-1.28, P=0.28). After adjustment for @entity1851 ( @entity1851 ), PCT did not provide additional prognostic information. CONCLUSIONS: PCT is associated with future cardiovascular mortality in @entity1 with @entity453 , but PCT is not superior to @entity1851 for prediction of outcome.

title: Association of serum @entity1904 with cardiovascular prognosis in XXXX .

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: BACKGROUND: Pediatric @entity1 with invasive @entity364 are often fragile hosts with multiple underlying conditions. Safety is an important feature of antifungal agents to be used in this setting. This study aims to evaluate safety of @entity1331 in pediatric @entity1 (<16 years of age), enrolled in different studies including pharmacokinetic evaluations and clinical trials for @entity3 , @entity7553 , and antifungal prophylaxis. METHODS: Adverse event (AE) data were pooled from 6 clinical trials conducted in Europe, the Americas, and Asia. RESULTS: A total of 296 @entity1 with a mean    standard deviation age of 6.5    5.1 years received >= 1 dose of @entity1331 ; 66 were <1 year of age; 38 were premature. Other common underlying conditions were hematopoietic stem cell transplantation (33.8%) and @entity1583 (29.1%). Approximately 40% of @entity1 were @entity1398 at baseline (absolute neutrophil count <500 cells/mm). Median daily @entity1331 dose was 1.7 mg/kg overall (range, 0.4-8.6 mg/kg) and 2.0 mg/kg (range, 0.8-7.7 mg/kg) for neonates <4 weeks old. Median treatment duration was 15 days (range, 1-425 days). During the study, AEs regardless of causality were recorded in 93.2% of subjects; 26.7% were classified as at least possibly related to study drug; and 34% of subjects had AEs meeting criteria for serious AE; of which, 4.7% of subjects experienced serious AEs at least possibly related to study drug. Study drug was discontinued because of AEs in 7 @entity1 (2.4%). No trends were observed with respect to analysis of AEs by dose or duration of treatment. CONCLUSIONS: @entity1331 was well tolerated by @entity1 of all ages including those with life-threatening underlying conditions. AEs thought to be drug related occasionally lead to discontinuation of the treatment.

title: Safety of XXXX in pediatric clinical trials.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity1331 :: ('MESH:C121905', 'Chemical') :: ['micafungin', 'Micafungin']

entities_list: @entity7553 :: ('MESH:D002177', 'Disease') :: ['candidiasis']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenic']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancy']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive aspergillosis']

answer: @entity1331 :: (MESH:C121905,Chemical) :: ['micafungin']


abstract: Over the last 30 years the process of @entity52 ( @entity52 ) has evolved considerably, yet the efficiency of this treatment remains relatively poor. The principal challenge faced by doctors and embryologists is the identification of the embryo with the greatest potential for producing a @entity1 . Current methods of embryo viability assessment provide only a rough guide to potential. In order to improve the odds of a successful pregnancy it is typical to transfer more than one embryo to the uterus. However, this often results in @entity2099 (twins, triplets, etc), which are associated with significantly elevated risks of serious complications. If embryo viability could be assessed more accurately, it would be possible to transfer fewer embryos without negatively impacting @entity52 pregnancy rates. In order to assist with the identification of viable embryos, several scoring systems based on morphological criteria have been developed. However, these mostly rely on a subjective visual analysis. Automated assessment of morphological features offers the possibility of more accurate quantification of key embryo characteristics and elimination of inter- and intra-observer variation. In this paper, we describe the main embryo scoring systems currently in use and review related works on embryo image analysis that could lead to an automatic and precise grading of embryo quality. We summarise achievements, discuss challenges ahead, and point to some possible future directions in this research field.

title: A review on automatic analysis of XXXX embryo microscope images.

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilisation']

entities_list: @entity2099 :: ('MESH:D011254', 'Disease') :: ['multiple pregnancies']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Ablations of anterior inferotemporal cortex in monkeys are known to impair learning when discriminations between members of several pairs of objects are taught concurrently. This deficit has been attributed to a loss of @entity227 . But ablations of hippocampus have also been shown to impair retention, and this impairment transcends the @entity227 . Therefore, in the first of two experiments, we compared the behavioral effects of @entity75 with those of either hippocampus, entorhinal area, or fornix, using a visual concurrent discrimination task. Monkeys with either @entity131 were impaired, while those with fornix sections were not. However, ablations of hippocampus included inadvertent damage of the inferotemporal cortex. Therefore, in the second experiment, behavioral effects of @entity75 were compared with those of hippocampus (without additional @entity16 ) on the concurrent task in both @entity227 . In the visual mode, monkeys with hippocampal removals were as impaired as those with inferotemporal ablations. In the tactual mode, however, hippocampal, but no inferotemporal, ablations were followed by a deficit. Our results, taken together with other existing evidence, emphasize the role of the hippocampus in mediating associative learning in more than one modality. These results, obtained with non- @entity1 primates, are in line with clinical findings.

title: Concurrent discrimination learning of monkeys after hippocampal, XXXX .

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual modality', 'visual mnemonic functions', 'visual and tactual modalities']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal or entorhinal ablations']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['inferotemporal cortical lesions', 'inferotemporal lesions']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['inferotemporal damage']

answer: @entity75 :: (MESH:D001927,Disease) :: ['entorhinal, or fornix lesions']


abstract: CONTEXT: Resection of adjacent visceral organs is often required in surgery for abdominal @entity361 . OBJECTIVES: To analyze the specific perioperative morbidity and mortality of a left pancreatectomy in multivisceral resections for @entity361 . @entity1 : This paper considered all @entity1 treated at National @entity5 Institute, Milan, Italy, from January 1997 to May 2009 for the resection of @entity1661 requiring a concomitant left pancreatectomy. The extension of surgery, pathology of both the @entity5 and the pancreatic tissue, completeness of resection, administration of pre or postoperative treatments and postoperative outcome were analyzed. The overall survival of the entire population was also assessed. RESULTS: Fifty-seven @entity1 affected by localized @entity8678 or intra-abdominal @entity674 were identified. A macroscopically complete resection was achieved in all but 3 @entity1 (5.3%) and the neoplastic involvement of pancreatic tissue was documented at pathology in 26 (45.6%) @entity1 . @entity260 occurred in 20 @entity1 (35.1%); 7 @entity1 (12.3%) developed a postoperative @entity3472 . With a median follow-up of the surviving @entity1 of 32 months (interquartile range: 20-57 months), the overall survival at 5 years was 67.0%. CONCLUSION: Left pancreatic resection seemed to be a safe procedure, even when it is part of a multivisceral resection for @entity1661 . When margins are crucial for cure, the left pancreas should then always be resected, independently of its direct infiltration.

title: Morbidity of left pancreatectomy when associated with multivisceral resection for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal mesenchymal neoplasms']

entities_list: @entity8678 :: ('MESH:D012186', 'Disease') :: ['left retroperitoneal mesenchymal neoplasms']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['Surgical postoperative complications']

entities_list: @entity3472 :: ('MESH:D010185', 'Disease') :: ['pancreatic fistula']

entities_list: @entity674 :: ('MESH:D046152', 'Disease') :: ['gastrointestinal stromal tumors']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['mesenchymal tumors']

answer: @entity1661 :: (MESH:D000008,Disease) :: ['abdominal mesenchymal neoplasms']


abstract: PURPOSE OF REVIEW: Ciliopathies are @entity74 caused by defects of primary ciliary structure and/or function and are characterized by pleiotropic clinical features. The ciliopathies include several partially overlapping syndromes such as @entity14475 , @entity21160 and @entity32973 , all of which have pronounced neurodevelopmental features. Here we focus on potential roles of cilia in central nervous system function, to explore how impairments may cause @entity75 and @entity16 . RECENT FINDINGS: Cilia have long been considered as 'sensory cellular antennae', responding as chemo-sensors, mechano-sensors and thermo-sensors, although their roles in development were not well understood until recently. The surprising finding that disparate syndromes are all due to defects of the primary cilia, along with the recent advances in genetics, has helped elucidate further roles of primary cilia beyond sensory functions. Several molecules that are associated with key signaling pathways have been discovered in primary cilia. These include sonic hedgehog, wingless, planar cell polarity and fibroblast growth factor, which are essential for many cellular processes. Additionally, mutations in 'ciliome' genes have largely shown @entity245 such as @entity854 and @entity75 , implying disrupted cilia-related signaling pathways. Accordingly, the emerging theme is that primary cilia may play roles as modulators of signal transduction to help shape cellular responses within the environmental context during both development and homeostasis. SUMMARY: The link between cilia and signal pathways has become a framework for understanding the pathogenesis of ciliopathies. Despite recent progress in ciliary biology, fundamental questions remain about how cilia regulate neuronal function in the central nervous system. Therefore, investigation of ciliary function in the nervous system may reveal cilia-modulating mechanisms in neurodevelopmental processes, as well as suggest new treatments for disease.

title: Cilia in the nervous system: linking cilia function and XXXX .

entities_list: @entity21160 :: ('MESH:D020788', 'Disease') :: ['Bardet-Biedl syndrome']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain malformation']

entities_list: @entity14475 :: ('MESH:C536293', 'Disease') :: ['Joubert syndrome']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurodevelopmental disease']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental defects']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormal body axis']

entities_list: @entity32973 :: ('MESH:C536133', 'Disease') :: ['Meckel-Gruber syndrome']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic disorders']

answer: @entity245 :: (MESH:D002658,Disease) :: ['neurodevelopmental disorders']


abstract: PURPOSE: : To establish the feasibility and effect of an aerobic exercise intervention on symptoms of @entity308 among individuals with @entity131 . DESIGN: : A pre-post single group. @entity1 : : our community dwelling @entity1 (>11 months postinjury) with residual physical impairment recruited from an outpatient clinic. INTERVENTION: : 12-week aerobic exercise program. OUTCOME MEASURES: : The Hamilton Rating Scale for @entity308 ; aerobic capacity (cycle ergometer, heart rate at reference resistance, perceived exertion); Rosenberg Self-Esteem Scale and program perception (survey). ANALYSIS: : Descriptive statistics to depict change in outcome measure scores. Answers from the survey were collated and presented as summary statements. RESULTS: : All @entity1 had fewer symptoms of @entity308 , improved aerobic capacity and higher self esteem after the intervention. High satisfaction with the program was reported with no adverse effects. CONCLUSION: : The aerobic exercise program was feasible and effective for individuals with @entity131 , leading to improved mood, @entity65 , and self-esteem. Future research is needed to determine the intensity, frequency, and duration required to reach and maintain improvement.

title: Feasibility and effect of aerobic exercise for lowering @entity308 among individuals with XXXX : a pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular fitness']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: PURPOSE: : To establish the feasibility and effect of an aerobic exercise intervention on symptoms of @entity308 among individuals with @entity131 . DESIGN: : A pre-post single group. @entity1 : : our community dwelling @entity1 (>11 months postinjury) with residual physical impairment recruited from an outpatient clinic. INTERVENTION: : 12-week aerobic exercise program. OUTCOME MEASURES: : The Hamilton Rating Scale for @entity308 ; aerobic capacity (cycle ergometer, heart rate at reference resistance, perceived exertion); Rosenberg Self-Esteem Scale and program perception (survey). ANALYSIS: : Descriptive statistics to depict change in outcome measure scores. Answers from the survey were collated and presented as summary statements. RESULTS: : All @entity1 had fewer symptoms of @entity308 , improved aerobic capacity and higher self esteem after the intervention. High satisfaction with the program was reported with no adverse effects. CONCLUSION: : The aerobic exercise program was feasible and effective for individuals with @entity131 , leading to improved mood, @entity65 , and self-esteem. Future research is needed to determine the intensity, frequency, and duration required to reach and maintain improvement.

title: Feasibility and effect of aerobic exercise for lowering XXXX among individuals with @entity131 : a pilot study.

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']


abstract: @entity19157 is the most common symptom among @entity1 presenting to the dermatology clinic. Scratching can cause mechanical @entity130 to the skin, further damaging the epidermal barrier and its function. This damage can facilitate the introduction of microbes that complicate the presenting disease and its management. @entity111 has a negative influence on quality of life. Initiation of treatment that can safely and effectively manage @entity111 may provide immediate benefits to the @entity1 . A novel topical formulation of @entity7496 2.5% and @entity61420 1% in a hydrophilic lotion base is indicated for the management of @entity111 . However, the rate of onset of antipruritic effects has not been well studied. This single-center, open-label, pilot study involved 11 subjects age 18 and older. All subjects applied @entity7496 2.5% and @entity61420 1% lotion four times daily for one day. Severity of @entity19157 as measured by the visual analog scale decreased significantly following one day of medication use. The change in mean visual analog scale from baseline was -2.16  2.78 (P=0.0275), representing a mean percentage reduction of 31.74  42.11 (P=0.0315). Topical application of @entity7496 2.5% and @entity61420 1% lotion provides a significant reduction in @entity111 as rated by @entity1 using the visual analog scale with a single day of use. Early onset of action to decrease @entity19157 is expected to improve the @entity1 's treatment experience and increase the level of long-term adherence.

title: Efficacy and onset of action of @entity7496 2.5% and XXXX 1% lotion for the management of @entity111 : results of a pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity7496 :: ('MESH:C021650', 'Chemical') :: ['hydrocortisone acetate']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['Pruritus', 'pruritus']

entities_list: @entity61420 :: ('MESH:C005548', 'Chemical') :: ['pramoxine hydrochloride']

answer: @entity61420 :: (MESH:C005548,Chemical) :: ['pramoxine hydrochloride']


abstract: @entity19157 is the most common symptom among @entity1 presenting to the dermatology clinic. Scratching can cause mechanical @entity130 to the skin, further damaging the epidermal barrier and its function. This damage can facilitate the introduction of microbes that complicate the presenting disease and its management. @entity111 has a negative influence on quality of life. Initiation of treatment that can safely and effectively manage @entity111 may provide immediate benefits to the @entity1 . A novel topical formulation of @entity7496 2.5% and @entity61420 1% in a hydrophilic lotion base is indicated for the management of @entity111 . However, the rate of onset of antipruritic effects has not been well studied. This single-center, open-label, pilot study involved 11 subjects age 18 and older. All subjects applied @entity7496 2.5% and @entity61420 1% lotion four times daily for one day. Severity of @entity19157 as measured by the visual analog scale decreased significantly following one day of medication use. The change in mean visual analog scale from baseline was -2.16  2.78 (P=0.0275), representing a mean percentage reduction of 31.74  42.11 (P=0.0315). Topical application of @entity7496 2.5% and @entity61420 1% lotion provides a significant reduction in @entity111 as rated by @entity1 using the visual analog scale with a single day of use. Early onset of action to decrease @entity19157 is expected to improve the @entity1 's treatment experience and increase the level of long-term adherence.

title: Efficacy and onset of action of XXXX 2.5% and @entity61420 1% lotion for the management of @entity111 : results of a pilot study.

answer: @entity7496 :: (MESH:C021650,Chemical) :: ['hydrocortisone acetate']


abstract: @entity19157 is the most common symptom among @entity1 presenting to the dermatology clinic. Scratching can cause mechanical @entity130 to the skin, further damaging the epidermal barrier and its function. This damage can facilitate the introduction of microbes that complicate the presenting disease and its management. @entity111 has a negative influence on quality of life. Initiation of treatment that can safely and effectively manage @entity111 may provide immediate benefits to the @entity1 . A novel topical formulation of @entity7496 2.5% and @entity61420 1% in a hydrophilic lotion base is indicated for the management of @entity111 . However, the rate of onset of antipruritic effects has not been well studied. This single-center, open-label, pilot study involved 11 subjects age 18 and older. All subjects applied @entity7496 2.5% and @entity61420 1% lotion four times daily for one day. Severity of @entity19157 as measured by the visual analog scale decreased significantly following one day of medication use. The change in mean visual analog scale from baseline was -2.16  2.78 (P=0.0275), representing a mean percentage reduction of 31.74  42.11 (P=0.0315). Topical application of @entity7496 2.5% and @entity61420 1% lotion provides a significant reduction in @entity111 as rated by @entity1 using the visual analog scale with a single day of use. Early onset of action to decrease @entity19157 is expected to improve the @entity1 's treatment experience and increase the level of long-term adherence.

title: Efficacy and onset of action of @entity7496 2.5% and @entity61420 1% lotion for the management of XXXX : results of a pilot study.

answer: @entity111 :: (MESH:D011537,Disease) :: ['pruritus']


abstract: An unusual case of @entity150 is presented. The cystectomy specimen contained one large @entity5 with the histological picture of a poorly-moderately well-differentiated @entity957 and another small @entity5 with poorly-differentiated @entity1606 . Besides, widespread areas of @entity2735 were seen. Random biopsies from the bladder and from the @entity5 were independently examined, histopathologically and by flow-cytofluorometric DNA-analyses. The degree of ploidy was found to be quite different between the two @entity5 . In areas of @entity2735 different aneuploid cll lines were indicated. Altogether five different aneuploid cell lines were found. There was a good correlation between the histopathological assessments and the DNA measurements: @entity2735 corresponding to aneuploidy and various degrees of atypia corresponding to diploidy. In @entity5 metastases from several organs, only one aneuploid cell line was found. This cell line did not correspond to those found in the @entity5 .

title: Detection of different DNA stem cell lines in a case of human XXXX .

entities_list: @entity2735 :: ('MESH:D002278', 'Disease') :: ['Carcinoma in situ', 'carcinoma in situ']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder carcinoma']

entities_list: @entity1606 :: ('MESH:D002295', 'Disease') :: ['transitional cell carcinoma']

answer: @entity150 :: (MESH:D001749,Disease) :: ['bladder carcinoma']


abstract: BACKGROUND: A history of abdominal surgery have long been considered a contraindication to laparoscopy. There was a reluctance to advocate the use of laparoscopy in mechanical @entity1744 due to technical difficulties related to a distended small intestine, and a small work space. AIMS: To report the results of laparoscopic treatment of small bowel mechanical obstruction and to study the factors for conversion to laparotomy. METHODS: Our study is retrospective, having compiled 32 @entity1 between January 2001 and December 2009. The average age was 35 years (20-54). There were 17 @entity1 and 15 @entity1 . History of laparotomies were noted in 27 @entity1 . Were excluded from this study @entity1 with strangulated @entity547 or eventration. An analysis was conducted to determine the conversion factors to laparotomy RESULTS: The flanges or postoperative adhesions were responsible for 27 of the 32 @entity1321 (84%). In 24 cases there was a single flange or localized adhesions treated by simple section successfully in 18 @entity1 (56% of cases). A conversion was performed in 14 cases (44%). the median time to recovery of intestinal transit was shorter after laparoscopic surgery completely after conversion (1.5 vs. 2.5 days, p = 0.004). Similarly, the median length of postoperative stay was shorter in the absence of conversion (2.4 vs 7, p <0.001). Statistical analysis identified four factors related to conversion, which are: the presence of peritoneal signs, the number of brackets> 1, and the need for a bowel resection. CONCLUSION: Laparoscopy is an option for the treatment of mechanical @entity1744 when performed in selected @entity1 . His best indication could be the occlusion of single flange. This alternative to laparotomy could reduce adhesion formation and potentially reduce future episodes of obstruction.

title: [Laparoscopic treatment of mechanical small XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['bowel obstruction']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstructions']

answer: @entity1744 :: (MESH:D043183,Disease) :: ['bowel obstruction']


abstract: BACKGROUND: Obesity is associated with poorer outcomes in @entity1 with hormone receptor-positive @entity0 . This association is not well established for @entity1 with @entity0 ( @entity0 ). In this study, the prognostic effects of body mass index on clinical outcome were evaluated in @entity1 with @entity0 . METHODS: A retrospective study was conducted on 418 @entity1 who were treated between July 1996 and July 2010 for @entity0 . @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) were evaluated in relation to body mass index (BMI) after controlling for clinically significant variables. RESULTS: One hundred twenty-four @entity1 (29.7%) were normal/underweight (BMI  <=24.9 kg/m(2) ), 130 @entity1 (31.1%) were overweight (BMI from 25 to 29.9 kg/m(2) ), and 164 @entity1 (39.2%) were @entity28 (BMI >= 30 kg/m(2) ). At a median follow-up of 37.2 months, there were 105 recurrences (25.1%) and 87 deaths (20.8%). Compared with normal/underweight @entity1 , the multivariate hazard ratio (HR) for @entity1349 was 0.81 (95% confidence interval [CI], 0.49-1.34) for @entity28 @entity1 . Similarly, @entity1349 was not associated with BMI category; @entity28 @entity1 had an HR of death of 0.94 (95% CI, 0.54-1.64) compared with normal/underweight @entity1 . A Cox regression analysis identified the receipt of chemotherapy (HR, 0.25; 95% CI, 0.12-0.52), ductal histology (HR, 0.49; 95% CI, 0.25-0.97), @entity5 (HR, 3.5; 95% CI, 1.35-9.06), and increasing @entity5 size (HR, 1.19; 95% CI, 1.09-1.3) as independent prognostic factors for @entity1349 . CONCLUSIONS: No significant relation between @entity28 and @entity1349 or @entity1349 emerged in @entity1 with @entity0 after controlling for clinically significant factors.

title: Impact of body mass index on clinical outcomes in triple-negative XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'TNBC', 'triple-negative breast cancers']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stage III disease']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'Recurrence-free survival', 'overall survival']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: Aberrant reprogramming of donor somatic cell nuclei may result in many severe problems in animal cloning. The inability to establish functional interactions between donor nucleus and recipient mitochondria is also likely responsible for such a @entity851 . However, detailed knowledge of protein expression during @entity1358 ( @entity1358 ) in @entity291 is lacking. In the present study, variations in mitochondrial protein levels between @entity1358 -derived and control @entity291 , and from @entity291 derived by artificial insemination were investigated. Mitochondrial fractions were prepared from frozen liver samples and subjected to two-dimensional (2-D) fluorescence differential gel electrophoresis (DIGE) using CyDye    dyes. Protein expression changes were confirmed with a volume ratio greater than 2.0 (P   <   0.05). 2D-DIGE analysis revealed differential expression of three proteins for @entity1358 @entity291 (n   =   4) and seven proteins for @entity1358 @entity291 (n   =   6) compared to controls (P   <   0.05). Different protein patterning was observed among @entity1358 animals even if animals were generated from the same donor cell source. No differences were detected in two of the @entity1358 @entity291 . Moreover, there was no novel protein identified in any of the @entity1358 @entity291 or @entity291 . In conclusion, variation in mitochondrial protein expression concentrations was observed in non-viable, neonatal @entity1358 @entity291 and among @entity1358 individuals. This result implicates mitochondrial-related gene expression in early developmental loss of @entity1358 embryos. Comparative proteomic analysis represents an important tool for further studies on @entity1358 animals.

title: Comparison of liver mitochondrial proteins derived from newborn cloned XXXX and from cloned adult @entity291 by two-dimensional differential gel electrophoresis.

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['somatic cell nuclear transfer', 'SCNT']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['developmental deficiency']

answer: @entity291 :: (9913,Species) :: ['calves']


abstract: Aberrant reprogramming of donor somatic cell nuclei may result in many severe problems in animal cloning. The inability to establish functional interactions between donor nucleus and recipient mitochondria is also likely responsible for such a @entity851 . However, detailed knowledge of protein expression during @entity1358 ( @entity1358 ) in @entity291 is lacking. In the present study, variations in mitochondrial protein levels between @entity1358 -derived and control @entity291 , and from @entity291 derived by artificial insemination were investigated. Mitochondrial fractions were prepared from frozen liver samples and subjected to two-dimensional (2-D) fluorescence differential gel electrophoresis (DIGE) using CyDye    dyes. Protein expression changes were confirmed with a volume ratio greater than 2.0 (P   <   0.05). 2D-DIGE analysis revealed differential expression of three proteins for @entity1358 @entity291 (n   =   4) and seven proteins for @entity1358 @entity291 (n   =   6) compared to controls (P   <   0.05). Different protein patterning was observed among @entity1358 animals even if animals were generated from the same donor cell source. No differences were detected in two of the @entity1358 @entity291 . Moreover, there was no novel protein identified in any of the @entity1358 @entity291 or @entity291 . In conclusion, variation in mitochondrial protein expression concentrations was observed in non-viable, neonatal @entity1358 @entity291 and among @entity1358 individuals. This result implicates mitochondrial-related gene expression in early developmental loss of @entity1358 embryos. Comparative proteomic analysis represents an important tool for further studies on @entity1358 animals.

title: Comparison of liver mitochondrial proteins derived from newborn cloned @entity291 and from cloned adult XXXX by two-dimensional differential gel electrophoresis.

answer: @entity291 :: (9913,Species) :: ['cattle']


abstract: OBJECTIVES: To evaluate weight loss maintenance after 4 years of nonpharmacological, nonsurgical @entity28 treatment, including a very low calorie diet (VLCD), diet and behavioural support. Furthermore, to assess weight development amongst completers and noncompleters beyond the active 4-year treatment period. DESIGN: Clinical trial. SETTING: Two Swedish county hospitals. SUBJECTS: A total of 113 @entity1 were randomized to a 2-year treatment programme with or without an initial VLCD period. The 87 @entity1 who completed the 2-year programme were offered the chance to continue a support programme for another 2 years. A total of 55 @entity1 completed the entire 4-year programme. INTERVENTIONS: All the @entity1 took part in a comprehensive support programme, including a hypocaloric diet and behavioural support, either as single treatment (non-VLCD group) or following the VLCD period (VLCD group). RESULTS: Significant 4-year weight losses were found in both groups, 7.6 +/- 12.2 kg (VLCD group) and 6.3 +/- 8.5 kg (non-VLCD group), (P < 0.01, n.s. between groups). The completers (n = 55) had maintained a weight loss of 3.3 +/- 10.7 kg (P < 0.05) 8 years after randomization. After 6 years, the noncompleters (n = 58) had gained 3.2 +/- 9.7 kg compared with baseline (P < 0.05). The difference in weight change between completers and non-completers was highly significant (P < 0.01). CONCLUSIONS: Highly significant weight losses can be maintained after a 4-year comprehensive treatment programme, including a hypocaloric diet and behavioural support. An initial VLCD period did not significantly affect the long-term weight loss. The posttreatment long-term weight loss was larger amongst completers than amongst @entity1 who did not complete the treatment.

title: A dietary and behavioural programme for the treatment of XXXX . A 4-year clinical trial and a long-term posttreatment follow-up.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']