abstract: [Purpose] @entity239 ( @entity239 ) and @entity890 ( @entity890 ) are a common diseases commonly encountered in physical therapy clinics. There are also @entity1 who have both of these diseases. In this study we aim to investigated whether @entity239 is a risk factor for @entity890 and the frequency of their coincident occurrence. [Subjects and Methods] Thirty-five @entity1 having a primary @entity239 diagnosis according to the American @entity627 Association criteria are taken into consideration and a control group were the subjects of this study. The two groups were compared with respect to cervical disc hernia using cervical region MRI. [Results] The distribution of disc hernia of 6 @entity239 @entity1 who had @entity3799 was: 16.6% @entity4049 , 16.6% @entity9509 , 16.6% C6-7, 33.3% C4-5, @entity9509 (two levels in two @entity1 ) and 16.6% C4-5, @entity9509 , C7-1 (three levels in one @entity1 ) . The herniation directions were given as: central in 5 levels, right paramedian in 1 level, and left paramedian disc hernia in 1 level. There were 4 cervical disk hernia in the control group. The herniation direction were central in two, right paramedian in one, and left paramedian in one @entity1 . [Conclusion] In this study, the existence of @entity890 in @entity239 @entity1 was found to be not different from the normal population.

title: Concomitance of XXXX syndrome and @entity890 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia', 'FMS', 'Fibromyalgia syndrome']

entities_list: @entity627 :: ('MESH:D012216', 'Disease') :: ['Rheumatism']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['cervical discopathy']

entities_list: @entity890 :: ('MESH:D007405', 'Disease') :: ['cervical disc herniation', 'CDH']

answer: @entity239 :: (MESH:D005356,Disease) :: ['fibromyalgia']


abstract: [Purpose] @entity239 ( @entity239 ) and @entity890 ( @entity890 ) are a common diseases commonly encountered in physical therapy clinics. There are also @entity1 who have both of these diseases. In this study we aim to investigated whether @entity239 is a risk factor for @entity890 and the frequency of their coincident occurrence. [Subjects and Methods] Thirty-five @entity1 having a primary @entity239 diagnosis according to the American @entity627 Association criteria are taken into consideration and a control group were the subjects of this study. The two groups were compared with respect to cervical disc hernia using cervical region MRI. [Results] The distribution of disc hernia of 6 @entity239 @entity1 who had @entity3799 was: 16.6% @entity4049 , 16.6% @entity9509 , 16.6% C6-7, 33.3% C4-5, @entity9509 (two levels in two @entity1 ) and 16.6% C4-5, @entity9509 , C7-1 (three levels in one @entity1 ) . The herniation directions were given as: central in 5 levels, right paramedian in 1 level, and left paramedian disc hernia in 1 level. There were 4 cervical disk hernia in the control group. The herniation direction were central in two, right paramedian in one, and left paramedian in one @entity1 . [Conclusion] In this study, the existence of @entity890 in @entity239 @entity1 was found to be not different from the normal population.

title: Concomitance of @entity239 syndrome and XXXX .

answer: @entity890 :: (MESH:D007405,Disease) :: ['cervical disc herniation']


abstract: Angiotensin receptor blockers (ARBs) have organ-protective effects in @entity712 and may be also effective in @entity632 -induced @entity296 (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, @entity48152 , in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle ( @entity3105 -only group, n=22), 5 mg/kg of @entity48152 (Low-fima group, n=22), and 10 mg/kg of @entity48152 (High-fima group, n=19). @entity3105 was injected once a week for six weeks. Echocardiography and hemodynamic assessment was performed at the 8th week using a miniaturized conductance catheter. Survival rate of the High-fima group was greater (100%) than that of the Low-fima (75%) and @entity3105 -only groups (50%). Echocardiography showed preserved left ventricular (LV) ejection fraction in the High-fima group, but not in the @entity3105 -only group (P=0.002). LV dimensions increased in the @entity3105 -only group; however, remodeling was attenuated in the Low-fima and High-fima groups. Hemodynamic assessment showed higher dP/dt in the High-fima group compared with the @entity3105 -only group. A novel ARB, @entity48152 , may prevent @entity3105 -CMP and improve survival rate in a dose-dependent manner in a @entity35 model of DOX-CMP and could be a treatment option for the prevention of DOX-CMP.

title: A Novel Angiotensin Type I Receptor Antagonist, XXXX , Prevents @entity632 -induced Cardiotoxicity in @entity35 .

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity48152 :: ('MESH:C558933', 'Chemical') :: ['fimasartan']

answer: @entity48152 :: (MESH:C558933,Chemical) :: ['Fimasartan']


abstract: Angiotensin receptor blockers (ARBs) have organ-protective effects in @entity712 and may be also effective in @entity632 -induced @entity296 (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, @entity48152 , in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle ( @entity3105 -only group, n=22), 5 mg/kg of @entity48152 (Low-fima group, n=22), and 10 mg/kg of @entity48152 (High-fima group, n=19). @entity3105 was injected once a week for six weeks. Echocardiography and hemodynamic assessment was performed at the 8th week using a miniaturized conductance catheter. Survival rate of the High-fima group was greater (100%) than that of the Low-fima (75%) and @entity3105 -only groups (50%). Echocardiography showed preserved left ventricular (LV) ejection fraction in the High-fima group, but not in the @entity3105 -only group (P=0.002). LV dimensions increased in the @entity3105 -only group; however, remodeling was attenuated in the Low-fima and High-fima groups. Hemodynamic assessment showed higher dP/dt in the High-fima group compared with the @entity3105 -only group. A novel ARB, @entity48152 , may prevent @entity3105 -CMP and improve survival rate in a dose-dependent manner in a @entity35 model of DOX-CMP and could be a treatment option for the prevention of DOX-CMP.

title: A Novel Angiotensin Type I Receptor Antagonist, @entity48152 , Prevents XXXX -induced Cardiotoxicity in @entity35 .

answer: @entity632 :: (MESH:D004317,Chemical) :: ['Doxorubicin']


abstract: Angiotensin receptor blockers (ARBs) have organ-protective effects in @entity712 and may be also effective in @entity632 -induced @entity296 (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, @entity48152 , in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle ( @entity3105 -only group, n=22), 5 mg/kg of @entity48152 (Low-fima group, n=22), and 10 mg/kg of @entity48152 (High-fima group, n=19). @entity3105 was injected once a week for six weeks. Echocardiography and hemodynamic assessment was performed at the 8th week using a miniaturized conductance catheter. Survival rate of the High-fima group was greater (100%) than that of the Low-fima (75%) and @entity3105 -only groups (50%). Echocardiography showed preserved left ventricular (LV) ejection fraction in the High-fima group, but not in the @entity3105 -only group (P=0.002). LV dimensions increased in the @entity3105 -only group; however, remodeling was attenuated in the Low-fima and High-fima groups. Hemodynamic assessment showed higher dP/dt in the High-fima group compared with the @entity3105 -only group. A novel ARB, @entity48152 , may prevent @entity3105 -CMP and improve survival rate in a dose-dependent manner in a @entity35 model of DOX-CMP and could be a treatment option for the prevention of DOX-CMP.

title: A Novel Angiotensin Type I Receptor Antagonist, @entity48152 , Prevents @entity632 -induced Cardiotoxicity in XXXX .

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: BACKGROUND/AIM: One of the factors known to contribute to a 'good life' following an acquired disability is making connections with others, often achieved through participation in activities outside the home. The majority of outcomes research following SCI has focussed on impairments and activity limitations with less emphasis on participation. This paper reports part of a larger study that explored the experience and meaning of @entity497 following SCI. The research question guiding the part of the study reported in this paper was: What are the facilitators and barriers to @entity497 following acquired SCI? METHODS: Semi-structured interviews were conducted with 17 adults with traumatically acquired @entity1566 living in the community. Interviews were audio-recorded, transcribed verbatim and analysed using thematic analysis. RESULTS: Three main themes and 11 subthemes were identified. The main themes were: Resources and environmental accessibility impact social participation; other @entity1 influence community engagement; health issues affect social participation. Adequate financial resources and social support (from friends and family, and from peer mentors) were found to assist social participation, while the physical environment, unsupportive social attitudes and mental health issues were identified as barriers to community participation. CONCLUSIONS: This study contributes to the evidence base regarding outcomes following SCI. Enabling engagement in meaningful activities in the community must be at the forefront of occupational therapy intervention, both at an individual client level and through advocacy and policy involvement, to improve the quality of life of @entity1 with SCI living in the community.

title: Facilitators and barriers to XXXX following @entity1566 .

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

entities_list: @entity497 :: ('MESH:D003147', 'Disease') :: ['social and community participation']

answer: @entity497 :: (MESH:D003147,Disease) :: ['social and community participation']


abstract: BACKGROUND/AIM: One of the factors known to contribute to a 'good life' following an acquired disability is making connections with others, often achieved through participation in activities outside the home. The majority of outcomes research following SCI has focussed on impairments and activity limitations with less emphasis on participation. This paper reports part of a larger study that explored the experience and meaning of @entity497 following SCI. The research question guiding the part of the study reported in this paper was: What are the facilitators and barriers to @entity497 following acquired SCI? METHODS: Semi-structured interviews were conducted with 17 adults with traumatically acquired @entity1566 living in the community. Interviews were audio-recorded, transcribed verbatim and analysed using thematic analysis. RESULTS: Three main themes and 11 subthemes were identified. The main themes were: Resources and environmental accessibility impact social participation; other @entity1 influence community engagement; health issues affect social participation. Adequate financial resources and social support (from friends and family, and from peer mentors) were found to assist social participation, while the physical environment, unsupportive social attitudes and mental health issues were identified as barriers to community participation. CONCLUSIONS: This study contributes to the evidence base regarding outcomes following SCI. Enabling engagement in meaningful activities in the community must be at the forefront of occupational therapy intervention, both at an individual client level and through advocacy and policy involvement, to improve the quality of life of @entity1 with SCI living in the community.

title: Facilitators and barriers to @entity497 following XXXX .

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: OBJECTIVE: This study was designed to estimate the clinical significance of the @entity16565 for prediction of postoperative survival in @entity1 with @entity14 ( @entity14 ). BACKGROUND: The @entity18880 ( @entity18880 ), calculated from the serum levels of @entity1851 and albumin, is well known to be a valuable @entity32 -based prognostic system for several types of @entity5 . A recent study has demonstrated that the @entity16565 is also useful for prediction of treatment outcome in @entity1 with @entity157 . METHODS: Uni- and multivariate analyses using the Cox proportional hazards model were performed to detect the clinical characteristics that were most closely associated with @entity1349 ( @entity1349 ). All recommended cutoff values were defined using receiver operating characteristic curve analyses. Kaplan-Meier analysis was used to compare @entity1349 curves between the two groups. RESULTS: A total of 627 @entity1 who had undergone elective @entity14 surgery were enrolled. Multivariate analysis using the results of univariate analyses demonstrated that @entity16565 (>0.038/ <=0.038) was associated with @entity1349 (hazard ratio 2.596; 95  % confidence interval 1.603-4.204; P  <  0.001) along with pathological differentiation (others/well or moderately), carcinoembryonic antigen level (>8.7/ <=8.7, ng/ml), stage (III, IV/0, I, II), neutrophil to lymphocyte ratio (NLR) (>2.9/ <=2.9), and @entity18880 (2/0, 1). Kaplan-Meier analysis and log rank test demonstrated a significant difference in @entity1349 curves between @entity1 with low @entity16565 ( <=0.038) and those with high @entity16565 (>0.038; P  <  0.001). CONCLUSIONS: @entity16565 is as useful for predicting the postoperative survival of @entity1 with @entity14 as previously reported @entity32 -based prognostic systems, such as @entity18880 and NLR.

title: Clinical Significance of the XXXX to Albumin Ratio for Survival After Surgery for @entity14 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity18880 :: ('MESH:C536506', 'Disease') :: ['Glasgow Prognostic Score', 'GPS']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

entities_list: @entity16565 :: ('653108', 'Gene') :: ['C-reactive protein (CRP)/albumin ratio (CAR)', 'CAR']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1851 :: (1401,Gene) :: ['C-Reactive Protein']


abstract: OBJECTIVE: This study was designed to estimate the clinical significance of the @entity16565 for prediction of postoperative survival in @entity1 with @entity14 ( @entity14 ). BACKGROUND: The @entity18880 ( @entity18880 ), calculated from the serum levels of @entity1851 and albumin, is well known to be a valuable @entity32 -based prognostic system for several types of @entity5 . A recent study has demonstrated that the @entity16565 is also useful for prediction of treatment outcome in @entity1 with @entity157 . METHODS: Uni- and multivariate analyses using the Cox proportional hazards model were performed to detect the clinical characteristics that were most closely associated with @entity1349 ( @entity1349 ). All recommended cutoff values were defined using receiver operating characteristic curve analyses. Kaplan-Meier analysis was used to compare @entity1349 curves between the two groups. RESULTS: A total of 627 @entity1 who had undergone elective @entity14 surgery were enrolled. Multivariate analysis using the results of univariate analyses demonstrated that @entity16565 (>0.038/ <=0.038) was associated with @entity1349 (hazard ratio 2.596; 95  % confidence interval 1.603-4.204; P  <  0.001) along with pathological differentiation (others/well or moderately), carcinoembryonic antigen level (>8.7/ <=8.7, ng/ml), stage (III, IV/0, I, II), neutrophil to lymphocyte ratio (NLR) (>2.9/ <=2.9), and @entity18880 (2/0, 1). Kaplan-Meier analysis and log rank test demonstrated a significant difference in @entity1349 curves between @entity1 with low @entity16565 ( <=0.038) and those with high @entity16565 (>0.038; P  <  0.001). CONCLUSIONS: @entity16565 is as useful for predicting the postoperative survival of @entity1 with @entity14 as previously reported @entity32 -based prognostic systems, such as @entity18880 and NLR.

title: Clinical Significance of the @entity1851 to Albumin Ratio for Survival After Surgery for XXXX .

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: OBJECTIVE: In this study, we aimed to determine the significance of the staging systems (EORTC, De Groot, MACIS, and @entity2802 ) on the prognosis of @entity259 @entity1 who underwent surgery in our clinics. MATERIAL AND METHODS: This retrospective study included 181 @entity1 who were operated between December 1995-December 2007, with a diagnosis of @entity259 . In order to obtain data related to @entity5 staging, a computer program for @entity2461 was developed to facilitate parameter recording. Survival analysis was performed. The findings were compared to the predicted rates by the staging systems. RESULTS: According to the De Groot staging system, stage 1 and stage 2 @entity1 ' results were compatible, but stage 3 and 4 @entity1 ' results were different (stage 3; 87% versus 66.6%, stage 4; 35% versus 100%, p=0.04). In the MACIS staging system, 20-year survival rates are determined and comparison should not be made due to insufficient follow-up period in this study. When compared to the EORTC staging system, stage 3 and stage 4 @entity1 ' results were determined different (stage 3; 51% versus 100%, stage 4; 33% versus 50%, p=0.02). The most consistent results in terms of prognosis was determined in comparison with the @entity2802 staging system (stage 1; 100% versus 97.8%, stage 4; 45.3% versus 50%). CONCLUSION: Many classification systems are proposed for @entity259 , to predict the behavior of the @entity5 . In this study, we concluded that for determination of prognosis in @entity259 , the @entity2802 staging system could best predict prognosis consistent with clinical findings.

title: The importance of staging systems for the determination of prognosis of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['well-differentiated thyroid cancer', 'thyroid cancer']

answer: @entity259 :: (MESH:D013964,Disease) :: ['well-differentiated thyroid cancer']


abstract: Preclinical evidence suggests that anesthetic agents harm the developing brain thereby causing long-term @entity149 . It is not clear if these findings apply to @entity1 , and retrospective epidemiological studies thus far have failed to show definitive evidence that anesthetic agents are harmful to the developing @entity1 brain. AIM: The aim of this systematic review was to summarize the preclinical studies published over the past decade, with a focus on methodological issues, to facilitate the comparison between different preclinical studies and inform better design of future trials. METHOD: The literature search identified 941 articles related to the topic of @entity2359 . As the primary aim of this systematic review was to compare methodologies applied in animal studies to inform future trials, we excluded a priori all articles focused on putative mechanism of @entity2359 and the neuroprotective agents. Forty-seven preclinical studies were finally included in this review. RESULTS: Methods used in these studies were highly heterogeneous-animals were exposed to anesthetic agents at different developmental stages, in various doses and in various combinations with other drugs, and overall showed diverse @entity137 profiles. Physiological monitoring and maintenance of physiological homeostasis was variable and the use of cognitive tests was generally limited to assessment of specific brain areas, with restricted translational relevance to @entity1 . CONCLUSION: Comparison between studies is thus complicated by this heterogeneous methodology and the relevance of the combined body of literature to @entity1 remains uncertain. Future preclinical studies should use better standardized methodologies to facilitate transferability of findings from preclinical into clinical science.

title: A systematic review of methodology applied during preclinical anesthetic XXXX studies: important issues and lessons relevant to the design of future clinical research.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive impairments']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity2359 :: (MESH:D020258,Disease) :: ['neurotoxicity']


abstract: OBJECTIVE: Completion thyroidectomy is recommended in @entity1 who have been diagnosed with @entity259 on histopathological evaluation, if their first operation was a conservative approach. The critical issue is when to do the second operation. MATERIAL AND METHODS: The medical records of 66 @entity1 who underwent completion thyroidectomy for the treatment of @entity259 in our clinic between 2006-2013 were retrospectively analyzed. All data were compared after @entity1 were divided into two groups according to the interval between the first surgery and completion thyroidectomy. RESULTS: Fifty-two @entity1 (78.8%) were @entity1 and 14 @entity1 (21.2%) were male. Completion thyroidectomy was performed 10-90 days after the initial surgery (group 1) in 26 @entity1 , whereas it was performed later than 90 days in 40 @entity1 (group 2). @entity346 occurred in two @entity1 (7.7%) in group 1, and in 3 @entity1 (7.5%) in group 2. Transient recurrent @entity3746 was observed in 1 @entity1 (3.9%) in group 1, and in 1 @entity1 (2.5%) in group 2. There were no permanent morbidities in both groups. @entity41 rate after completion thyroidectomy was 45.5%. There was no statistically significant difference between the two groups in terms of complications after completion thyroidectomy. CONCLUSION: Although in some studies it is recommended that completion thyroidectomy should be performed either before scar tissue development or after clinical remission of scar tissue, @entity4 and @entity32 , we believe that timing of surgery has no effect on morbidity.

title: Completion thyroidectomy in XXXX : When to perform?

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['Residual tumor']

entities_list: @entity346 :: ('MESH:D009759', 'Disease') :: ['Temporary hypoparathyroidism']

entities_list: @entity3746 :: ('MESH:D014826', 'Disease') :: ['laryngeal nerve palsy']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['differentiated thyroid cancer']

answer: @entity259 :: (MESH:D013964,Disease) :: ['differentiated thyroid cancer']


abstract: OBJECTIVE: The aim was to evaluate the parameters that were considered by Forensic Medicine in @entity1157 as well as the issues that the physicians were found to be faulty. MATERIAL AND METHODS: The following parameters were investigated in 21 files that were referred to Istanbul Forensic Medicine Institute with request of expert opinion between 2008-2012; expert decisions, @entity1 's age, gender, written @entity1 consent, diagnosis, type of first surgery, surgical complications, timing of complication diagnosis within the scope of complication management, @entity1 's referral timing, troubleshooting procedures and mortality rate. RESULTS: Physicians were found to be faulty in all files. The reason for physician fault was failure to show the necessary professional care and attention in one (4.7%) file, late recognition of @entity130 @entity1 in 20 (95.3%) files. Written consent had not been obtained in any of the files. Thirteen @entity1 were female (61.9%) and 8 (30.1%) were male, with a mean age of 43.3 years. Nineteen @entity1 had @entity2963 (90.4%), and two @entity1 (9.5%) had a mass in the head of the pancreas. Cholecystectomy was performed laparoscopically in 15 @entity1 (78.9%), and with open surgery in 4 @entity1 (21.1%). The Whipple procedure was performed in two @entity1 . The diagnosis was made during the operation in one @entity1 (4.7%), and in the post-operative period in 20 @entity1 (95.3%). The time to diagnosis after surgery was between 3-6 days. All of the @entity1 had been referred to third level health care facilities. The timing of transfer was 1 day in the @entity1 who was diagnosed during the operation, and ranged between 4-10 days in those who were diagnosed postoperatively. Reasons for late referral were delays related to pending test results in 12 @entity1 , vague signs in 3 @entity1 , and following-up @entity1 with the thought that the @entity3116 will heal by itself in 5 @entity1 . Mortality was not observed in any of the examined files. CONCLUSION: The issues where physicians were most frequently found to be faulty were failure to obtain written @entity1 consent, late recognition of @entity130 @entity1 .

title: The retrospective documentation of legal cases with XXXX that were submitted for consideration to   stanbul Forensic Medicine Institute by the courts between 2008-2012.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1157 :: ('MESH:D001649', 'Disease') :: ['bile duct injury']

entities_list: @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis']

entities_list: @entity3116 :: ('MESH:D001658', 'Disease') :: ['biliary fistula']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injury and late transfer of the']

answer: @entity1157 :: (MESH:D001649,Disease) :: ['bile duct injury']


abstract: A 53-year-old male who was being followed up by a nephrology department because of type V crescentic @entity631 was admitted with abdominal @entity158 to our clinic. He was diagnosed with @entity1028 after the examinations. Aortic repair with a tubular graft was performed. Pathological examination of the @entity439 tissue showed @entity364 . We started antifungal chemotherapy with @entity2379 . A separation of the graft body occurred, and the @entity1 was reoperated on. An excision of the graft, ligation of the aorta, and axillobifemoral graft by-pass was performed. At the 15(th) month of his discharge, the @entity1 was readmitted to the emergency room of our clinic suffering from hematemesis. According to the examinations, an aortoduodenal @entity292 was diagnosed, and we performed a partial duodenal resection and end-to-end duodenoduodenostomy. We want to share this unusual, interesting, and complicated case, operated on several times because of a @entity5880 due to a @entity364 .

title: A real @entity5880 of the abdominal aorta due to XXXX .

entities_list: @entity5880 :: ('MESH:D000785', 'Disease') :: ['mycotic aneurysm']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infection', 'fungal hyphae']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm']

answer: @entity364 :: (MESH:D009181,Disease) :: ['fungal infection']


abstract: A 53-year-old male who was being followed up by a nephrology department because of type V crescentic @entity631 was admitted with abdominal @entity158 to our clinic. He was diagnosed with @entity1028 after the examinations. Aortic repair with a tubular graft was performed. Pathological examination of the @entity439 tissue showed @entity364 . We started antifungal chemotherapy with @entity2379 . A separation of the graft body occurred, and the @entity1 was reoperated on. An excision of the graft, ligation of the aorta, and axillobifemoral graft by-pass was performed. At the 15(th) month of his discharge, the @entity1 was readmitted to the emergency room of our clinic suffering from hematemesis. According to the examinations, an aortoduodenal @entity292 was diagnosed, and we performed a partial duodenal resection and end-to-end duodenoduodenostomy. We want to share this unusual, interesting, and complicated case, operated on several times because of a @entity5880 due to a @entity364 .

title: A real XXXX of the abdominal aorta due to @entity364 .

answer: @entity5880 :: (MESH:D000785,Disease) :: ['mycotic aneurysm-mycotic aneurysm']


abstract: AIM: To compare @entity989 ( @entity989 ) of @entity1 with @entity9998 with healthy controls and investigate the correlations between retinal nerve fiber layer (RNFL) thickness parameters and @entity989 . METHODS: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All @entity1 underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera (Topcon 501X). @entity989 were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal, temporal and average RNFL thicknesses were recorded. @entity989 and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation tests. RESULTS: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group (P=0.009, P=0.038, respectively). No statistically significant difference regarding @entity989 was found between two groups. CONCLUSION: @entity989 seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and @entity989 show significant correlations in both groups. This correlation doesn't seem to be specific to PSX.

title: Retinal vessel diameters and their correlation with retinal nerve fiber layer thickness in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity9998 :: ('MESH:D017889', 'Disease') :: ['pseudoexfoliation (PSX) syndrome']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal artery-vein diameters', 'RAVDs']

answer: @entity9998 :: (MESH:D017889,Disease) :: ['pseudoexfoliation syndrome']


abstract: AIM: To compare @entity989 ( @entity989 ) of @entity1 with @entity9998 with healthy controls and investigate the correlations between retinal nerve fiber layer (RNFL) thickness parameters and @entity989 . METHODS: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All @entity1 underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera (Topcon 501X). @entity989 were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal, temporal and average RNFL thicknesses were recorded. @entity989 and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation tests. RESULTS: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group (P=0.009, P=0.038, respectively). No statistically significant difference regarding @entity989 was found between two groups. CONCLUSION: @entity989 seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and @entity989 show significant correlations in both groups. This correlation doesn't seem to be specific to PSX.

title: Retinal vessel diameters and their correlation with retinal nerve fiber layer thickness in XXXX with @entity9998 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Malignant @entity96 with osteoclast-like giant cells are rare. A literature search showed 17 previously reported cases that included the following: (1) 8 undifferentiated @entity157 , (2) 5 @entity5 with osteoclast-like giant cells associated with @entity1419 or @entity409 , and (3) 4 @entity5 with osteoclast-like giant cells associated with areas of a @entity157 . CASE PRESENTATION: A 68-year-old @entity1 presented with a @entity5 of the right lobe of the liver on ultrasonography and computed tomography. Laparoscopy showed a @entity5 (diameter, 4  cm) in segments 7 and 8 of the right liver lobe that adhered to the retroperitoneum. The @entity5 recurred 3  months after liver segmentectomy. Repeat laparoscopy showed diffuse and nodular metastases to the omentum and peritoneum. RESULT: Light microscopy showed that part of the @entity5 had features of classic @entity157 . Another part of the @entity5 had a solid sarcomatous pattern with osteoclast-like giant cells that were irregularly distributed between the smaller undifferentiated @entity5 cells; cells of this part of the @entity5 were positive for heppar-1. CONCLUSION: Light microscopic findings including osteoclast-like giant cells, and the strong reaction of heppar-1 antibody with cells of the sarcomatous part of the @entity5 , confirmed that this sarcomatous element was a metaplastic or transformed portion of @entity157 . VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6000512901462616.

title: Immunohistochemical evaluation of a XXXX with osteoclastlike giant cells.

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'sarcomatoid tumors', 'sarcomatous tumors']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver cystadenocarcinoma']

entities_list: @entity1419 :: ('MESH:C535533', 'Disease') :: ['intrahepatic cholangiocarcinoma']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['conventional hepatocellular carcinoma', 'hepatocellular carcinoma', 'hepatocellular carcinomas']

answer: @entity157 :: (MESH:D006528,Disease) :: ['sarcomatoid hepatocellular carcinoma']


abstract: We tested whether cardiac mass can be related to decreased @entity2333 in an original @entity35 model of isolated systolic @entity101 . Increased @entity2333 was produced by @entity460 overload of elastic arteries after @entity3875 plus @entity1239 treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor @entity4687 (1 mg/kg per day PO). @entity35 were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by @entity2647 infusion, and carotidofemoral pulse wave velocity was measured. This value together with those for thoracic aorta internal diameter and medial thickness (determined after in situ fixation and histomorphometry) were used to calculate elastic modulus. @entity3875 plus @entity1239 treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two. There was no significant change in resistance. Treatment with @entity4687 reversed the changes in cardiac mass and elastic modulus but had no effect on resistance after @entity460 overload of the elastic arteries. In this model of isolated systolic @entity101 , we showed that cardiac mass is related to arterial elasticity.

title: @entity2333 and left ventricular mass in a @entity35 model of isolated systolic XXXX .

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity3875 :: ('MESH:D002762', 'Chemical') :: ['Vitamin D3', 'vitamin D3']

entities_list: @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic stiffness']

entities_list: @entity4687 :: ('MESH:D020913', 'Chemical') :: ['perindopril']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: We tested whether cardiac mass can be related to decreased @entity2333 in an original @entity35 model of isolated systolic @entity101 . Increased @entity2333 was produced by @entity460 overload of elastic arteries after @entity3875 plus @entity1239 treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor @entity4687 (1 mg/kg per day PO). @entity35 were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by @entity2647 infusion, and carotidofemoral pulse wave velocity was measured. This value together with those for thoracic aorta internal diameter and medial thickness (determined after in situ fixation and histomorphometry) were used to calculate elastic modulus. @entity3875 plus @entity1239 treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two. There was no significant change in resistance. Treatment with @entity4687 reversed the changes in cardiac mass and elastic modulus but had no effect on resistance after @entity460 overload of the elastic arteries. In this model of isolated systolic @entity101 , we showed that cardiac mass is related to arterial elasticity.

title: XXXX and left ventricular mass in a @entity35 model of isolated systolic @entity101 .

answer: @entity2333 :: (MESH:D001018,Disease) :: ['Aortic stiffness']


abstract: We tested whether cardiac mass can be related to decreased @entity2333 in an original @entity35 model of isolated systolic @entity101 . Increased @entity2333 was produced by @entity460 overload of elastic arteries after @entity3875 plus @entity1239 treatment. Half of the animals were chronically treated with the angiotensin-converting enzyme inhibitor @entity4687 (1 mg/kg per day PO). @entity35 were pithed, and lower body vascular resistance was measured. Blood pressure was then increased by @entity2647 infusion, and carotidofemoral pulse wave velocity was measured. This value together with those for thoracic aorta internal diameter and medial thickness (determined after in situ fixation and histomorphometry) were used to calculate elastic modulus. @entity3875 plus @entity1239 treatment produced parallel increases in cardiac mass and elastic modulus, with a significant correlation between the two. There was no significant change in resistance. Treatment with @entity4687 reversed the changes in cardiac mass and elastic modulus but had no effect on resistance after @entity460 overload of the elastic arteries. In this model of isolated systolic @entity101 , we showed that cardiac mass is related to arterial elasticity.

title: @entity2333 and left ventricular mass in a XXXX model of isolated systolic @entity101 .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: RNA-Seq is an efficient way to comprehensively identify single nucleotide polymorphisms (SNPs) and @entity4373 ( @entity4373 ) events from the expressed genes. In this study, we conducted transcriptome sequencing of four Asian lotus ( @entity16666 ) cultivars using Illumina HiSeq2000 platform to identify SNPs and @entity4373 events in lotus. A total of 505 million pair-end RNA-Seq reads were generated from four cultivars, of which 86% were mapped to the lotus reference genome. Using the four sets of data together, a total of 357,689 putative SNPs were identified with an average density of one SNP per 2.2 kb. These SNPs were located in 1,253 scaffolds and 15,016 expressed genes. A/G and C/T were the two major types of SNPs in the Asian lotus transcriptome. In parallel, a total of 177,540 @entity4373 events were detected in the four cultivars and were distributed in 64% of the expressed genes of lotus. The predominant type of @entity4373 events was alternative 5' first exon, which accounted for 41.2% of all the observed @entity4373 events, and exon skipping only accounted for 4.3% of all @entity4373 . Gene Ontology analysis was conducted to analyze the function of the genes containing SNPs and @entity4373 events. Validation of selected SNPs and @entity4373 events revealed that 74% of SNPs and 80% of @entity4373 events were reliable, which indicates that RNA-Seq is an efficient approach to uncover gene-associated SNPs and @entity4373 events. A large number of SNPs and @entity4373 events identified in our study will facilitate further genetic and functional genomics research in lotus.

title: RNA-Seq Uncovers SNPs and Alternative Splicing Events in Asian Lotus ( XXXX ).

entities_list: @entity16666 :: ('4432', 'Species') :: ['Nelumbo nucifera']

entities_list: @entity4373 :: ('MESH:C536589', 'Disease') :: ['AS', 'alternative splicing']

answer: @entity16666 :: (4432,Species) :: ['Nelumbo nucifera']


abstract: Azaspiracid (AZA) @entity4968 was unknown until 1995 when shellfish harvested in Ireland caused @entity221 manifesting by @entity391 and @entity294 . Further in vivo/vitro studies showed @entity2359 linked with AZA exposure. However, the biological target of the toxin which will help explain such potent @entity16 is still unknown. A region of Irish coastline was selected and shellfish were sampled and tested for AZA using mass spectrometry. An outbreak was identified in 2010 and samples collected before and after the contamination episode were compared for their metabolite profile using high resolution mass spectrometry. Twenty eight ions were identified at higher concentration in the contaminated samples. Stringent bioinformatic analysis revealed putative identifications for seven compounds including, glutarylcarnitine, a glutaric acid metabolite. Glutaric acid, the parent compound linked with @entity1 neurological manifestations was subjected to toxicological investigations but was found to have no specific effect on the sodium channel (as was the case with AZA). However in combination, glutaric acid (1mM) and azaspiracid (50nM) inhibited the activity of the sodium channel by over 50%. Glutaric acid was subsequently detected in all shellfish employed in the study. For the first time a viable mechanism for how AZA manifests itself as a toxin is presented.

title: New insights into the causes of @entity1 XXXX due to consumption of azaspiracid contaminated shellfish.

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological activity']

entities_list: @entity4968 :: ('MESH:D011041', 'Disease') :: ['poisoning']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity221 :: (MESH:D005334,Disease) :: ['illness']


abstract: Azaspiracid (AZA) @entity4968 was unknown until 1995 when shellfish harvested in Ireland caused @entity221 manifesting by @entity391 and @entity294 . Further in vivo/vitro studies showed @entity2359 linked with AZA exposure. However, the biological target of the toxin which will help explain such potent @entity16 is still unknown. A region of Irish coastline was selected and shellfish were sampled and tested for AZA using mass spectrometry. An outbreak was identified in 2010 and samples collected before and after the contamination episode were compared for their metabolite profile using high resolution mass spectrometry. Twenty eight ions were identified at higher concentration in the contaminated samples. Stringent bioinformatic analysis revealed putative identifications for seven compounds including, glutarylcarnitine, a glutaric acid metabolite. Glutaric acid, the parent compound linked with @entity1 neurological manifestations was subjected to toxicological investigations but was found to have no specific effect on the sodium channel (as was the case with AZA). However in combination, glutaric acid (1mM) and azaspiracid (50nM) inhibited the activity of the sodium channel by over 50%. Glutaric acid was subsequently detected in all shellfish employed in the study. For the first time a viable mechanism for how AZA manifests itself as a toxin is presented.

title: New insights into the causes of XXXX @entity221 due to consumption of azaspiracid contaminated shellfish.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: @entity1496 -induced @entity2743 , which raises several diagnostic and therapeutical challenges, is often overlooked. @entity1378 can induce @entity955 , a harmful @entity943 which can precipitate @entity712 and cause @entity64 . We report the case of an elderly @entity1 who was diagnosed with tachyfibrillation secondary to @entity1378 . Thyroid @entity6392 was subsequently related both to previous @entity2643 therapy (probably mixed form) and the recent use of iodinated contrast medium for computed tomography scan. Thyroid ultrasonography showed a @entity1376 . After initial worsening, thyroid function improved slowly but progressively on high-dose thyreostatic therapy combined with @entity479 therapy; tachyfibrillation caused @entity712 and a @entity715 in the left atrium, and proved initially resistant to combined antiarrhythmic treatments. Progressive reduction in thyroid hormone levels, together with combined cardiologic therapies, controlled the heart rate, though @entity955 persisted; anticoagulant therapy resolved the @entity715 . Alterations in thyroid function are common in @entity2643 -treated @entity1 , who therefore require regular hormonal checks. The different forms of @entity2643 -induced @entity2743 must be investigated, since they require different therapies, though mixed forms often occur. The superimposition of further @entity1496 excess due to other causes may be catastrophic and cause severe cardiac problems in these @entity1 .

title: XXXX -induced @entity1378 as combination of different etiologies: an overlooked entity in the elderly.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'man']

entities_list: @entity1496 :: ('MESH:D007455', 'Chemical') :: ['iodine', 'Iodine']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity2643 :: ('MESH:D000638', 'Chemical') :: ['amiodarone']

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ['thyrotoxicosis']

entities_list: @entity1376 :: ('MESH:C564546', 'Disease') :: ['plongeant multinodular goitre']

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['Hyperthyroidism', 'hyperthyroidism']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity6392 :: ('MESH:D000308', 'Disease') :: ['hyperfunction']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['atrial thrombus', 'thrombus']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity1496 :: (MESH:D007455,Chemical) :: ['Iodine']


abstract: UNASSIGNED: @entity1496 -induced @entity2743 , which raises several diagnostic and therapeutical challenges, is often overlooked. @entity1378 can induce @entity955 , a harmful @entity943 which can precipitate @entity712 and cause @entity64 . We report the case of an elderly @entity1 who was diagnosed with tachyfibrillation secondary to @entity1378 . Thyroid @entity6392 was subsequently related both to previous @entity2643 therapy (probably mixed form) and the recent use of iodinated contrast medium for computed tomography scan. Thyroid ultrasonography showed a @entity1376 . After initial worsening, thyroid function improved slowly but progressively on high-dose thyreostatic therapy combined with @entity479 therapy; tachyfibrillation caused @entity712 and a @entity715 in the left atrium, and proved initially resistant to combined antiarrhythmic treatments. Progressive reduction in thyroid hormone levels, together with combined cardiologic therapies, controlled the heart rate, though @entity955 persisted; anticoagulant therapy resolved the @entity715 . Alterations in thyroid function are common in @entity2643 -treated @entity1 , who therefore require regular hormonal checks. The different forms of @entity2643 -induced @entity2743 must be investigated, since they require different therapies, though mixed forms often occur. The superimposition of further @entity1496 excess due to other causes may be catastrophic and cause severe cardiac problems in these @entity1 .

title: @entity1496 -induced XXXX as combination of different etiologies: an overlooked entity in the elderly.

answer: @entity1378 :: (MESH:D006980,Disease) :: ['hyperthyroidism']


abstract: BACKGROUND: Obesity is correlated with several comorbidities, including @entity354 . Its main complications are detectable by endoscopy: @entity2910 and @entity355 . AIM: To correlate @entity2910 and @entity357 with the degree of body mass index (BMI). METHOD: Was performed a retrospective analysis of 717 preoperative endoscopic reports of bariatric @entity1 . Fifty-six (8%) presented @entity357 , being 44 small, nine medium and five large. @entity2910 was classified by Los Angeles classification. RESULTS: There was no correlation between the presence and dimension of @entity357 with BMI. One hundred thirty-four (18.7%) @entity1 presented @entity2910 . Among them, 104 (14.5%) had @entity2910 grade A; 25 (3.5%) grade B; and five (0.7%) grade C. When considering only the @entity1 with @entity2910 , 77.6% had @entity2910 grade A, 18.7% grade B and 3.7% grade C. Were identified only two @entity1 with @entity355 (0,28%). CONCLUSION: There was a positive correlation between the degree of @entity2910 with increasing BMI.

title: ENDOSCOPIC CHANGES RELATED TO GASTROESOPHAGEAL REFLUX DISEASE: COMPARATIVE STUDY AMONG BARIATRIC SURGERY XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"]

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['erosive esophagitis', 'esophagitis', 'Esophagitis']

entities_list: @entity357 :: ('MESH:D006551', 'Disease') :: ['hiatal hernia']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease']

answer: @entity1 :: (9606,Species) :: ['PATIENTS']


abstract: BACKGROUND: Subcutaneous @entity3139 -like @entity784 represent a rare and difficult to diagnose entity of @entity784 . SPTL affects predominantly young adults and presents with multifocal subcutaneous nodules and frequently associated autoimmune features. The pathogenesis of SPTL is not completely understood. METHODS: The aim of this study was to unravel molecular pathways critical to the SPTL pathogenesis. Therefore, we analyzed 23 skin samples from 20 newly diagnosed SPTL @entity1 and relevant control samples of adipose and non-malignant @entity3139 tissue by using gene expression microarray, quantitative PCR, and two-colour immunohistochemistry. RESULTS: Interestingly, @entity3035 2,3-dioxygenase ( @entity9218 ), an immunotolerance-inducing enzyme, was among the most highly overexpressed genes in all comparisons. The expression of @entity1198 -specific cytokines, known to be associated with @entity32 (i.e. @entity379 , @entity366 , @entity373 , @entity371 , @entity372 , and @entity5737 ), were also significantly increased. Confirmed using immunohistochemistry, the morphologically malignant lymphocytes expressed @entity366 and @entity373 . @entity9218 expression was found both in some morphologically malignant lymphocytes rimming the adipocytes and in surrounding @entity2935 (-) CD68(-) cells but not in @entity2935 (+) dendritic cells in the microenvironment. The proportion of @entity403 + cells in SPTL exceeded that in the benign @entity3139 samples. CONCLUSIONS: Our results indicate that the up regulation of the tolerogenic @entity9218 together with the up regulation of @entity379 , @entity366 ligands, and @entity5737 are features of SPTL lesions. We anticipate that the @entity379 -inducible @entity9218 expression contributes to the formation of an immunosuppressive microenvironment, favorable for the malignant T cells. This study provides a relevant molecular basis for further studies exploring novel therapeutic means for subcutaneous @entity784 .

title: Molecular characterization of subcutaneous @entity3139 -like XXXX reveals upregulation of immunosuppression- and autoimmunity-associated genes.

entities_list: @entity3035 :: ('CHEBI:28626', 'Chemical') :: ['indoleamine']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['autoimmune inflammation']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T cell lymphoma', 'T cell lymphomas', 'cutaneous T cell lymphomas']

entities_list: @entity3139 :: ('MESH:D015434', 'Disease') :: ['panniculitis']

answer: @entity784 :: (MESH:D016399,Disease) :: ['T-cell lymphoma']


abstract: BACKGROUND: Subcutaneous @entity3139 -like @entity784 represent a rare and difficult to diagnose entity of @entity784 . SPTL affects predominantly young adults and presents with multifocal subcutaneous nodules and frequently associated autoimmune features. The pathogenesis of SPTL is not completely understood. METHODS: The aim of this study was to unravel molecular pathways critical to the SPTL pathogenesis. Therefore, we analyzed 23 skin samples from 20 newly diagnosed SPTL @entity1 and relevant control samples of adipose and non-malignant @entity3139 tissue by using gene expression microarray, quantitative PCR, and two-colour immunohistochemistry. RESULTS: Interestingly, @entity3035 2,3-dioxygenase ( @entity9218 ), an immunotolerance-inducing enzyme, was among the most highly overexpressed genes in all comparisons. The expression of @entity1198 -specific cytokines, known to be associated with @entity32 (i.e. @entity379 , @entity366 , @entity373 , @entity371 , @entity372 , and @entity5737 ), were also significantly increased. Confirmed using immunohistochemistry, the morphologically malignant lymphocytes expressed @entity366 and @entity373 . @entity9218 expression was found both in some morphologically malignant lymphocytes rimming the adipocytes and in surrounding @entity2935 (-) CD68(-) cells but not in @entity2935 (+) dendritic cells in the microenvironment. The proportion of @entity403 + cells in SPTL exceeded that in the benign @entity3139 samples. CONCLUSIONS: Our results indicate that the up regulation of the tolerogenic @entity9218 together with the up regulation of @entity379 , @entity366 ligands, and @entity5737 are features of SPTL lesions. We anticipate that the @entity379 -inducible @entity9218 expression contributes to the formation of an immunosuppressive microenvironment, favorable for the malignant T cells. This study provides a relevant molecular basis for further studies exploring novel therapeutic means for subcutaneous @entity784 .

title: Molecular characterization of subcutaneous XXXX -like @entity784 reveals upregulation of immunosuppression- and autoimmunity-associated genes.

answer: @entity3139 :: (MESH:D015434,Disease) :: ['panniculitis']


abstract: UNASSIGNED: We examined the effects of @entity38001 in @entity35 subjected to @entity8638 ( @entity8638 ). @entity38001 (50, 100, and 200   mg/kg, i.p.), was administered from the day of surgery for 14   days. Spinal cord levels of apoptotic factors and glia markers were quantified on days 3, 7, and 14 post- @entity8638 . Oxidative stress markers were assessed on days 7 and 14. @entity8638 @entity35 exhibited a marked mechanical @entity1931 , @entity1931 , and thermal @entity1931 on days 3, 5, 7, 10, and 14 post- @entity8638 . A significant increase in the levels of Iba (a marker of microglia activation) and @entity2310 (a proapoptotic factor) was observed on day 3. Iba remained high on day 7. In contrast, there were no differences in glial fibrillary acidic protein contents between sham and @entity8638 animals. @entity1234 increased and reduced @entity2041 decreased on day 14. @entity38001 significantly attenuated behavioral changes associated with @entity16 . @entity2310 decreased, while @entity1976 was increased by @entity38001 on day 3. @entity38001 also reduced Iba protein on days 3 and 7. The results support evidence that microglial activation, apoptotic factors, and oxidative stress may have a pivotal role in the @entity9 pathogenesis. It is suggested that antinociceptive effects elicited by @entity38001 might be through the inhibition of microglia activation, apoptotic pathways, and antioxidant properties. Copyright    2015 John Wiley _ Sons, Ltd.

title: The Effect of @entity38001 in XXXX Induced by Chronic Constriction Injury in @entity35 .

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia', 'cold allodynia', 'hyperalgesia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity38001 :: ('MESH:C058956', 'Chemical') :: ['Verbascoside', 'verbascoside']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['Malondialdehyde']

entities_list: @entity8638 :: ('MESH:D020208', 'Disease') :: ['chronic constriction injury', 'CCI']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']

answer: @entity9 :: (MESH:D009437,Disease) :: ['Neuropathic Pain']


abstract: UNASSIGNED: We examined the effects of @entity38001 in @entity35 subjected to @entity8638 ( @entity8638 ). @entity38001 (50, 100, and 200   mg/kg, i.p.), was administered from the day of surgery for 14   days. Spinal cord levels of apoptotic factors and glia markers were quantified on days 3, 7, and 14 post- @entity8638 . Oxidative stress markers were assessed on days 7 and 14. @entity8638 @entity35 exhibited a marked mechanical @entity1931 , @entity1931 , and thermal @entity1931 on days 3, 5, 7, 10, and 14 post- @entity8638 . A significant increase in the levels of Iba (a marker of microglia activation) and @entity2310 (a proapoptotic factor) was observed on day 3. Iba remained high on day 7. In contrast, there were no differences in glial fibrillary acidic protein contents between sham and @entity8638 animals. @entity1234 increased and reduced @entity2041 decreased on day 14. @entity38001 significantly attenuated behavioral changes associated with @entity16 . @entity2310 decreased, while @entity1976 was increased by @entity38001 on day 3. @entity38001 also reduced Iba protein on days 3 and 7. The results support evidence that microglial activation, apoptotic factors, and oxidative stress may have a pivotal role in the @entity9 pathogenesis. It is suggested that antinociceptive effects elicited by @entity38001 might be through the inhibition of microglia activation, apoptotic pathways, and antioxidant properties. Copyright    2015 John Wiley _ Sons, Ltd.

title: The Effect of XXXX in @entity9 Induced by Chronic Constriction Injury in @entity35 .

answer: @entity38001 :: (MESH:C058956,Chemical) :: ['Verbascoside']


abstract: UNASSIGNED: We examined the effects of @entity38001 in @entity35 subjected to @entity8638 ( @entity8638 ). @entity38001 (50, 100, and 200   mg/kg, i.p.), was administered from the day of surgery for 14   days. Spinal cord levels of apoptotic factors and glia markers were quantified on days 3, 7, and 14 post- @entity8638 . Oxidative stress markers were assessed on days 7 and 14. @entity8638 @entity35 exhibited a marked mechanical @entity1931 , @entity1931 , and thermal @entity1931 on days 3, 5, 7, 10, and 14 post- @entity8638 . A significant increase in the levels of Iba (a marker of microglia activation) and @entity2310 (a proapoptotic factor) was observed on day 3. Iba remained high on day 7. In contrast, there were no differences in glial fibrillary acidic protein contents between sham and @entity8638 animals. @entity1234 increased and reduced @entity2041 decreased on day 14. @entity38001 significantly attenuated behavioral changes associated with @entity16 . @entity2310 decreased, while @entity1976 was increased by @entity38001 on day 3. @entity38001 also reduced Iba protein on days 3 and 7. The results support evidence that microglial activation, apoptotic factors, and oxidative stress may have a pivotal role in the @entity9 pathogenesis. It is suggested that antinociceptive effects elicited by @entity38001 might be through the inhibition of microglia activation, apoptotic pathways, and antioxidant properties. Copyright    2015 John Wiley _ Sons, Ltd.

title: The Effect of @entity38001 in @entity9 Induced by Chronic Constriction Injury in XXXX .

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: @entity904 and @entity1718 are critical to photoreceptor structure, function, and development. The transport of these nutrients between the pigment epithelium and @entity1274 is mediated by interphotoreceptor retinoid-binding protein ( @entity21232 ). @entity21232 , a 133-kDa ( @entity1 ) glycolipoprotein, is the major protein component of the extracellular matrix separating these two cell layers. In amphibians and mammals, @entity21232 consists of four homologous repeats of about 300 @entity1522 which form two @entity904 and four @entity844 -binding sites. Here we show that @entity21232 in teleosts is a simpler protein composed of only two repeats. Western blot analysis shows that @entity2083 @entity21232 is half the size (70 kDa) of @entity21232 in higher vertebrates. Metabolic labeling studies employing @entity10613 taken together with in situ hybridization studies and the presence of a signal peptide show that @entity2083 @entity21232 is secreted by the cone photoreceptors. The translated @entity535 sequence has a calculated molecular weight of 66.7 kDa. The primary structure consists of only two homologous repeats with a similarity score of 52.5%. The last repeats of @entity1 and @entity2083 IRBPs are 69.1% similar with hydrophobic regions being the most similar. These data suggest that two repeats were lost during the evolution of the ray-finned fish (Actinopterygii), or that the @entity21232 gene duplicated between the emergence of bony fish (Osteichthyes) and amphibians. Acquisition of a multirepeat structure may reflect evolutionary pressure to efficiently transport higher levels of hydrophobic molecules within a finite space. Quadruplication of an ancestral @entity21232 gene may have been an important event in the evolution of photo-receptors in higher vertebrates.

title: XXXX cones secrete a two-repeat interphotoreceptor retinoid-binding protein.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity904 :: ('MESH:D014801', 'Chemical') :: ['retinol', 'Vitamin A']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['neural retina']

entities_list: @entity10613 :: ('MESH:D020126', 'Chemical') :: ['Brefeldin A']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

answer: @entity2083 :: (7957,Species) :: ['Goldfish']


abstract: PURPOSE: The impact of prostatectomy on quality of life was assessed in @entity1 with @entity1067 ( @entity1067 ) who were classified according to the expected benefit from surgical intervention. The relative impact of the 2 surgical techniques (open versus closed) on short-term quality of life was compared. MATERIALS AND METHODS: An observational study was done on 545 consecutive @entity1 with @entity1067 undergoing prostatectomy at 3 medical centers in Israel between 1991 and 1992. Repeated structured interviews preoperatively, and at 4 and 12 months postoperatively were performed, including 6 quality of life questionnaires evaluating @entity1067 specific (symptom severity and symptom effect) and generic (activity, independence, mental health and health perception) parameters. In addition, the interviews consisted of socio-demographic data elements. Clinical details regarding severity of @entity4623 and co-morbidity were obtained from the medical charts. RESULTS: We found a correlation between postoperative change in symptom effect and in generic quality of life measures (r-0.11 to 0.20, p < 0.04). The postoperative decrease in the mean symptom effect score was 56% and 52% for severe and moderate preoperative levels, respectively. There was no decrease in the mean symptom effect score for the mild preoperative level (18% of these @entity1 had @entity86 ). A secondary operation, and the @entity6 and poor activity level were risk factors for lack of improvement in @entity1 with moderate preoperative symptom effects. We found that the impact of open prostatectomy on quality of life was similar to that of the closed technique after adjustment for @entity1 attributes, except for those with an indwelling urinary catheter in whom an open operation was advantageous. CONCLUSIONS: In @entity1 with @entity1067 and mild symptom effects, and in subgroups of @entity1 with moderate symptom effects surgery should not be recommended. Based on short-term measures of quality of life there is no justification for a preference between open and closed operations.

title: Factors affecting change in quality of life after prostatectomy for XXXX : the impact of surgical techniques.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['combination of diabetes mellitus']

entities_list: @entity1067 :: ('MESH:D011470', 'Disease') :: ['BPH', 'benign prostatic hypertrophy']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative deterioration']

entities_list: @entity4623 :: ('MESH:D011469', 'Disease') :: ['prostatic disease']

answer: @entity1067 :: (MESH:D011470,Disease) :: ['benign prostatic hypertrophy']


abstract: The purpose of this study was to evaluate the incidence and characteristics of @entity1 with port-site @entity3 following robotic assisted surgery for gynecological @entity5 . @entity1 who underwent robotic assisted total laparoscopic hysterectomy and surgical staging at a single institution from November 2006 through November 2011 were retrospectively identified. Medical records were reviewed and the following information was extracted: diagnosis, histology, @entity5 extension, procedure, complications and post-surgical intervention. Port-site @entity3 were differentiated between isolated and not isolated. All @entity3 were confirmed with biopsy and treated with chemotherapy and radiotherapy as indicated. Four hundred forty-six @entity1 with @entity1204 were identified who had undergone robotic assisted hysterectomy and staging. Eight @entity1 were converted to laparotomy and excluded from the study. Of 438 @entity1 , 384 @entity1 were diagnosed with early stages (stages 1 and 2), and 54 were diagnosed with advanced stages (stages 3 and 4). A total of 332 @entity1 underwent pelvic lymphadenectomy regardless of the @entity1204 ; of those, 283 with early stage disease underwent pelvic lymphadenectomy, while 49 with advanced stage disease underwent pelvic lymphadenectomy. One hundred seventy-six @entity1 received adjuvant treatment after surgical staging. Four @entity1 were identified with port-site @entity3 (0.9  %), two @entity1 were reported as isolated @entity3 . The mean @entity1 age was 63 and mean BMI was 37  kg/m(2). The incidence of port-site @entity3 is low after robotic assisted surgery for treatment of @entity1204 (0.9  %). There is no clear risk factor for development of port-site @entity3 or easily identifiable prevention.

title: Low incidence of port-site XXXX after robotic assisted surgery for @entity1204 staging: descriptive analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'endometrial cancer', 'endometrial cancer stage']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: The purpose of this study was to evaluate the incidence and characteristics of @entity1 with port-site @entity3 following robotic assisted surgery for gynecological @entity5 . @entity1 who underwent robotic assisted total laparoscopic hysterectomy and surgical staging at a single institution from November 2006 through November 2011 were retrospectively identified. Medical records were reviewed and the following information was extracted: diagnosis, histology, @entity5 extension, procedure, complications and post-surgical intervention. Port-site @entity3 were differentiated between isolated and not isolated. All @entity3 were confirmed with biopsy and treated with chemotherapy and radiotherapy as indicated. Four hundred forty-six @entity1 with @entity1204 were identified who had undergone robotic assisted hysterectomy and staging. Eight @entity1 were converted to laparotomy and excluded from the study. Of 438 @entity1 , 384 @entity1 were diagnosed with early stages (stages 1 and 2), and 54 were diagnosed with advanced stages (stages 3 and 4). A total of 332 @entity1 underwent pelvic lymphadenectomy regardless of the @entity1204 ; of those, 283 with early stage disease underwent pelvic lymphadenectomy, while 49 with advanced stage disease underwent pelvic lymphadenectomy. One hundred seventy-six @entity1 received adjuvant treatment after surgical staging. Four @entity1 were identified with port-site @entity3 (0.9  %), two @entity1 were reported as isolated @entity3 . The mean @entity1 age was 63 and mean BMI was 37  kg/m(2). The incidence of port-site @entity3 is low after robotic assisted surgery for treatment of @entity1204 (0.9  %). There is no clear risk factor for development of port-site @entity3 or easily identifiable prevention.

title: Low incidence of port-site @entity3 after robotic assisted surgery for XXXX staging: descriptive analysis.

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']


abstract: UNASSIGNED: The @entity291 tick (Rhipicephalus microplus) affects @entity291 industries in tropical and subtropical countries because it is the vector of @entity743 and @entity9187 which constitutes a threat to the health of @entity291 . During blooding feeding, ticks secrete saliva containing a complex of bioactive molecules into the injured site to evade host's defensive responses. Serine protease inhibitors (serpins) are important anti-haemostatic molecules present in tick saliva that are necessary for a successful blood feeding. Several serpin sequences have been reported in R. microplus but there is a gap of information about their functions during host-parasite interactions. In this study, the RmS-15 expressed in the @entity375 @entity10056 was characterised using kinetic assays and in vitro analysis. The inhibitory enzymatic assays conducted showed that RmS-15 is a physiological inhibitor of thrombin with a stoichiometric inhibition (SI) of 1.5 and high inhibition affinity with ka=9.3  0.5*104M(-1)s(-1). RmS-15 delayed the clotting of plasma in a dose-dependent manner as determined in a recalcification time assay. Significant elevated ELISA titres were observed in tick resistant and susceptible @entity291 on day 28 after the @entity277 (p<0.001). This data suggests direct contact of RmS-15 with the immune system of the host at the tick-feeding site. The present study contributed to the understanding of the biological functions of R. microplus serpins during host-parasite interactions which contributes to the design of future innovative methods for tick control.

title: Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the XXXX @entity10056 .

entities_list: @entity10056 :: ('4922', 'Species') :: ['Pichia pastoris']

entities_list: @entity9187 :: ('MESH:D000712', 'Disease') :: ['anaplasmosis']

entities_list: @entity277 :: ('MESH:D013984', 'Disease') :: ['tick infestation']

entities_list: @entity743 :: ('MESH:D001404', 'Disease') :: ['babesiosis']

answer: @entity375 :: (4932,Species) :: ['yeast']


abstract: UNASSIGNED: The @entity291 tick (Rhipicephalus microplus) affects @entity291 industries in tropical and subtropical countries because it is the vector of @entity743 and @entity9187 which constitutes a threat to the health of @entity291 . During blooding feeding, ticks secrete saliva containing a complex of bioactive molecules into the injured site to evade host's defensive responses. Serine protease inhibitors (serpins) are important anti-haemostatic molecules present in tick saliva that are necessary for a successful blood feeding. Several serpin sequences have been reported in R. microplus but there is a gap of information about their functions during host-parasite interactions. In this study, the RmS-15 expressed in the @entity375 @entity10056 was characterised using kinetic assays and in vitro analysis. The inhibitory enzymatic assays conducted showed that RmS-15 is a physiological inhibitor of thrombin with a stoichiometric inhibition (SI) of 1.5 and high inhibition affinity with ka=9.3  0.5*104M(-1)s(-1). RmS-15 delayed the clotting of plasma in a dose-dependent manner as determined in a recalcification time assay. Significant elevated ELISA titres were observed in tick resistant and susceptible @entity291 on day 28 after the @entity277 (p<0.001). This data suggests direct contact of RmS-15 with the immune system of the host at the tick-feeding site. The present study contributed to the understanding of the biological functions of R. microplus serpins during host-parasite interactions which contributes to the design of future innovative methods for tick control.

title: Effective inhibition of thrombin by Rhipicephalus microplus serpin-15 (RmS-15) obtained in the @entity375 XXXX .

answer: @entity10056 :: (4922,Species) :: ['Pichia pastoris']


abstract: OBJECTIVE: To present 57 cases of @entity29542 in @entity1 , analyzing the clinical characteristics, treatment and outcome of these lesions. METHODS: The clinical histories of @entity1 diagnosed with @entity29542 , seen between 1998 and 2008 at the Oral and Maxillofacial Surgery Unit of a reference @entity1 's Hospital (0-14 years) were reviewed. All @entity1 with clinical diagnosis of @entity29542 were included. RESULTS: Fifty-seven @entity1 , 21 @entity1 and 36 @entity1 , with a mean age of 5.1 years were included in the study. Thirty-two cases were located on the left side of the floor of the mouth. The lesion diameter varied between 1 and 3 cm in 27 cases, 22 were less than 1 cm, and 8 were larger than 3 cm. Fifty-four cases were asymptomatic and 3 ranulas had @entity158 on swallowing. Twenty-two cases were resolved by opening with a tract dilator and 35 by marsupialization. Seven cases recurred at a mean of 12 months after treatment, three of these from the marsupialization group. CONCLUSION: The majority of the oral ranulas occurred in females, asymptomatic, on the left side of the floor of the mouth, with a mean size of 1 to 3 cm; all lesions were treated by surgery, of which 7 recurred.

title: XXXX : clinical follow-up study of 57 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'girls', 'boys']

entities_list: @entity29542 :: ('MESH:D011900', 'Disease') :: ['oral ranula']

answer: @entity29542 :: (MESH:D011900,Disease) :: ['Pediatric oral ranula']


abstract: AIM: @entity5436 ( @entity5436 ) precedes the development of @entity957 . Detection of the lesion is essential to management. This paper describes a prospective study to detect and ablate anal @entity2784 ( @entity2784 ) using white light (WL) narrow band imaging (NBI) and NBI with @entity1543 (NBIA). METHOD: Sixty @entity1 with abnormal anal cytology and risk factors for @entity24103 , underwent examination of the anoderm with a high definition gastroscope and NBIA. Targeted biopsies were taken and the lesions ablated and characterized histopathologically. Visualisation of the anal transitional zone (ATZ) was facilitated by retroflexion and examination through a disposable anoscope. RESULTS: Targeted biopsies were taken from lesions in 58 @entity1 . No lesion was seen in two @entity1 . Histopathology showed @entity2784 in 48 (80.0%) of 60 biopsies. One biopsy showed @entity706 . Biopsies in 9 (15%) of the 60 @entity1 showed normal mucosa. Lesions were seen in white light in 27 (45%) of the 60 cases, NBI in 39(65%) and NBIA in 57(95%) . There was no major morbidity. Sensitivity analysis showed that all methods were significantly different from each other. CONCLUSION: Anal @entity2784 in the ATZ and anal canal can be identified by NBIAPatient selection influences findings. Limitations include small sample size and non-randomization. This article is protected by copyright. All rights reserved.

title: Detection of XXXX is enhanced by narrow band imaging and @entity1543 (NBIA).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoid aggregates']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['anal squamous cell carcinoma']

entities_list: @entity24103 :: ('MESH:C538254', 'Disease') :: ['anal dysplasia']

entities_list: @entity2784 :: ('MESH:D065310', 'Disease') :: ['squamous intraepithelial lesions', 'SIL']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

entities_list: @entity5436 :: ('MESH:D019048', 'Disease') :: ['Anal intraepithelial neoplasia', 'AIN']

answer: @entity24103 :: (MESH:C538254,Disease) :: ['anal dysplasia']


abstract: AIM: @entity5436 ( @entity5436 ) precedes the development of @entity957 . Detection of the lesion is essential to management. This paper describes a prospective study to detect and ablate anal @entity2784 ( @entity2784 ) using white light (WL) narrow band imaging (NBI) and NBI with @entity1543 (NBIA). METHOD: Sixty @entity1 with abnormal anal cytology and risk factors for @entity24103 , underwent examination of the anoderm with a high definition gastroscope and NBIA. Targeted biopsies were taken and the lesions ablated and characterized histopathologically. Visualisation of the anal transitional zone (ATZ) was facilitated by retroflexion and examination through a disposable anoscope. RESULTS: Targeted biopsies were taken from lesions in 58 @entity1 . No lesion was seen in two @entity1 . Histopathology showed @entity2784 in 48 (80.0%) of 60 biopsies. One biopsy showed @entity706 . Biopsies in 9 (15%) of the 60 @entity1 showed normal mucosa. Lesions were seen in white light in 27 (45%) of the 60 cases, NBI in 39(65%) and NBIA in 57(95%) . There was no major morbidity. Sensitivity analysis showed that all methods were significantly different from each other. CONCLUSION: Anal @entity2784 in the ATZ and anal canal can be identified by NBIAPatient selection influences findings. Limitations include small sample size and non-randomization. This article is protected by copyright. All rights reserved.

title: Detection of @entity24103 is enhanced by narrow band imaging and XXXX (NBIA).

answer: @entity1543 :: (MESH:D019342,Chemical) :: ['acetic acid']


abstract: INTRODUCTION: Hysterectomy for @entity1204 is increasingly performed by laparoscopic surgical technique. Same-day discharge is safe, cost-saving, and acceptable to @entity1 undergoing laparoscopic hysterectomy, but concerns about increased perioperative risks in @entity28 @entity1 limit the utilization of same-day discharge in this population. We evaluated the risk of perioperative complications in @entity28 @entity1 undergoing laparoscopic hysterectomy for @entity1204 or @entity1478 in our institution during a period of rapid increase in the utilization of same-day discharge. METHODS: Single-institution retrospective cohort including all @entity28 @entity1 (body mass index [calculated as weight (kg)/[height (m)]] 30) undergoing laparoscopic hysterectomy for @entity1204 or @entity1478 between 2011 and 2013. RESULTS: A total of 388 @entity1 were included. Those with class III @entity28 were younger than those with class I or II (58.4 compared with 63.0 years, P<.001) and less likely to have invasive @entity1204 (80.9% compared with 88.7%, P=.04). Those with class III @entity28 were significantly more likely to undergo robot-assisted laparoscopy than those with class I or II @entity28 (57.5% compared with 18.6%, P<.001). The rate of same-day discharge increased significantly over the 3-year study period: for those with class I and II @entity28 from 18.6% to 65.5% and for those with class III @entity28 from 12.7% to 61.4% (P<.001). During this period there were no significant differences in frequency of @entity260 within 30 days of surgery, including readmission, unscheduled surgery, or @entity281 (P=.1 for all). CONCLUSION: Same-day discharge is safe and feasible for the majority of @entity28 @entity1 undergoing laparoscopic surgery for @entity1204 and @entity1478 .

title: Safety and Feasibility of Same-Day Discharge in Obese @entity1 Undergoing Laparoscopic Hysterectomy for XXXX and Malignancy [335].

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1478 :: ('MESH:D014591', 'Disease') :: ['endometrial intraepithelial neoplasia']

answer: @entity1478 :: (MESH:D014591,Disease) :: ['Endometrial Intraepithelial Neoplasia']


abstract: INTRODUCTION: Hysterectomy for @entity1204 is increasingly performed by laparoscopic surgical technique. Same-day discharge is safe, cost-saving, and acceptable to @entity1 undergoing laparoscopic hysterectomy, but concerns about increased perioperative risks in @entity28 @entity1 limit the utilization of same-day discharge in this population. We evaluated the risk of perioperative complications in @entity28 @entity1 undergoing laparoscopic hysterectomy for @entity1204 or @entity1478 in our institution during a period of rapid increase in the utilization of same-day discharge. METHODS: Single-institution retrospective cohort including all @entity28 @entity1 (body mass index [calculated as weight (kg)/[height (m)]] 30) undergoing laparoscopic hysterectomy for @entity1204 or @entity1478 between 2011 and 2013. RESULTS: A total of 388 @entity1 were included. Those with class III @entity28 were younger than those with class I or II (58.4 compared with 63.0 years, P<.001) and less likely to have invasive @entity1204 (80.9% compared with 88.7%, P=.04). Those with class III @entity28 were significantly more likely to undergo robot-assisted laparoscopy than those with class I or II @entity28 (57.5% compared with 18.6%, P<.001). The rate of same-day discharge increased significantly over the 3-year study period: for those with class I and II @entity28 from 18.6% to 65.5% and for those with class III @entity28 from 12.7% to 61.4% (P<.001). During this period there were no significant differences in frequency of @entity260 within 30 days of surgery, including readmission, unscheduled surgery, or @entity281 (P=.1 for all). CONCLUSION: Same-day discharge is safe and feasible for the majority of @entity28 @entity1 undergoing laparoscopic surgery for @entity1204 and @entity1478 .

title: Safety and Feasibility of Same-Day Discharge in Obese XXXX Undergoing Laparoscopic Hysterectomy for @entity1478 and Malignancy [335].

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: @entity26370 rarely occur in naturally conceived pregnancies, one in 30,000. However, this rate drastically increases, one in 100, in the setting of assisted reproductive technology. Thus, the diagnosis and management of @entity26370 is imperative in a @entity1 undergoing @entity52 ( @entity52 ). CASE: A 27-year-old primigravid Caucasian @entity1 at 8 weeks of gestation presents to the emergency department with heavy @entity3556 . She underwent @entity52 with an uneventful transfer of two embryos approximately 8 weeks prior. The postoperative course was complicated by @entity43 with paracentesis. Four weeks posttransfer, the @entity1 had an episode of @entity3556 with a closed cervix. Two additional @entity548 episodes resulting in hospitalization and blood transfusion occurred during the eighth and ninth weeks of gestation. On the fourth episode of @entity548 an ultrasonogram showed a fetus with a heart rate in the cervical canal along with an intrauterine pregnancy. After explanation of risks and benefits, the @entity1 chose to have a curettage and cautery of the cervical canal. Bleeding ceased, the cervical pregnancy was terminated, and the intrauterine pregnancy went on to a term delivery. CONCLUSION: In this @entity26370 , treatment of the ectopic pregnancy was tailored to the site of implantation and successfully utilized invasive therapy to preserve the concomitant intrauterine pregnancy.

title: Rare Complication of Embryo Transfer: Cervical XXXX [354].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian hyperstimulation syndrome']

entities_list: @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity26370 :: ('MESH:D063192', 'Disease') :: ['heterotopic pregnancy', 'Heterotopic pregnancies']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilization']

answer: @entity26370 :: (MESH:D063192,Disease) :: ['Heterotopic Pregnancy']


abstract: OBJECTIVE: Epistaxis is the most frequent @entity341 with a high treatment morbidity. This study assessed the long-term outcome after @entity1415 treatment with regard to @entity1 comfort during the treatment, long-term complications and rate of recurrences. METHODS: A questionnaire cohort study was performed at the ENT department of the University Hospital Zurich. In April 2014, 363 @entity1 were contacted, who were treated between March 2007 and April 2008 for the reason of @entity1415 using a written questionnaire to elucidate the @entity1 ' condition after the treatment. The type of treatment, subjective discomfort as well as degree of @entity158 , complications, permanent sequelae and recurrences were assessed. RESULTS: 109 questionnaires were analyzed (response rate of 36%). The overall same-sided recurrence rate after successful treatment during the 6.4-year follow-up was 22%. Discomfort was reported in 48% after cautery, 86% after packing and in 11% after surgery. Strong or very strong @entity158 was perceived in 8% after cautery, 26% after packing and in 0% after surgery alone. Complications consisted of nasal crusting in 15% after cautery and nasal breathing impairment in 24% after packing. Permanent harm was reported in 4% after cautery versus 20% after packing plus surgery. CONCLUSIONS: The data confirm the high rate of recurrences despite adequate treatment in the long-term analysis. The rate of post-treatment complications is considerably high with nasal crusting being the main inconvenience. It further shows that @entity1 keep a vivid memory of the treatment even many years later and that packing is extremely uncomfortable to @entity1 .

title: The high rate of long-term recurrences and sequelae after XXXX treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1415 :: ('MESH:D004844', 'Disease') :: ['epistaxis']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['rhinologic emergency']

answer: @entity1415 :: (MESH:D004844,Disease) :: ['epistaxis']


abstract: BACKGROUND: Endoscopic submucosal dissection (ESD) has become one of the mainstays of treatment for early @entity356 (EGC). Radical surgery is also a classical treatment method for EGC. There have been no systematic clinical studies of the curative effects and adverse events associated with ESD vs. radical surgery for EGC. This study investigated the therapeutic efficacy and safety of ESD and radical surgery for EGC. METHODS: Twenty-nine @entity1 with EGC underwent ESD, and 59 underwent radical surgery at Weihai Municipal Hospital. The pathological characteristics, postoperative outcomes, hospital course, morbidity and mortality were retrospectively compared between the two groups. RESULTS: The oncological clearance was 93.1  % (27/29) in the ESD group. Postoperative delayed @entity548 occurred in two @entity1 . The hospital stay ranged from 10 to 23  days, and the average stay was 14.3        3.7  days. The @entity1 were followed-up for 1 to 5  years, with a mean follow-up of 26.9        8.5  months. Regular endoscopic examinations showed that the wound had healed with no @entity5 recurrence in all of the @entity1 . In the radical surgery group, the oncological clearance was 100  % (59/59). The hospital stay ranged from 11 to 55  days, and the average stay was 21.7        9.3  days. The @entity1 were followed-up for 1 to 3.7  years, with a mean follow-up of 22.3        9.4  months. Nine @entity1 developed complications, including acute @entity86 (1/59) and symptomatic residual @entity3621 (3/59). These complications were improved by an additional operation, @entity344 and comprehensive therapy. CONCLUSIONS: ESD achieved similar efficacy and had many advantages compared with radical surgery for the treatment of EGC.

title: A comparison of endoscopic submucosal dissection (ESD) and radical surgery for early XXXX : a retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['drainage, gastrointestinal decompression']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative adhesive ileus']

entities_list: @entity3621 :: ('MESH:D005756', 'Disease') :: ['gastritis']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: BACKGROUND: The deficit subtype of @entity161 is hypothesized to constitute a pathophysiologically distinct subgroup of @entity161 @entity1 suffering from enduring, @entity191 and various @entity51 . Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently, @entity1495 has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional @entity1495 @entity15606 gene polymorphism and the deficit and @entity51 subtypes of @entity161 . METHODS: The study was conducted between 2009 and 2012. Deficit @entity161 was diagnosed using the @entity214 . The sample consisted of 468 @entity1 , Caucasians, of Polish descent with @entity1479 10 diagnosis of @entity161 : 189 [51% males] were included in a @entity51 subgroup, 279 @entity1 [53% males] were included in a deficit subgroup. The control group consisted of 532 subjects, Caucasians, of Polish descent [51% males]. @entity1495 @entity15606 gene polymorphism was genotyped using the fluorescence resonance energy transfer (FRET) method and the Light Cycler System 2.0. RESULTS: The frequencies of genotypes and alleles did not differ between the @entity161 @entity1 and control group. The deficit and @entity51 @entity1 did not differ in terms of the genotype and allele frequencies. No differences were found in genotype and allele frequencies between the deficit @entity1 and the controls and between the @entity51 @entity1 and the controls. CONCLUSION: We found no evidence for the association between the functional @entity1495 @entity15606 gene polymorphism and deficit/ @entity51 subtypes of @entity161 .

title: Functional polymorphism of XXXX ( @entity1495 ) gene is not associated with @entity161 and with its deficit subtype.

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ['idiopathic negative symptoms']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['non-deficit', 'neuropsychological deficits']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity1495 :: (4318,Gene) :: ['matrix metalloproteinase-9']


abstract: BACKGROUND: The deficit subtype of @entity161 is hypothesized to constitute a pathophysiologically distinct subgroup of @entity161 @entity1 suffering from enduring, @entity191 and various @entity51 . Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently, @entity1495 has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional @entity1495 @entity15606 gene polymorphism and the deficit and @entity51 subtypes of @entity161 . METHODS: The study was conducted between 2009 and 2012. Deficit @entity161 was diagnosed using the @entity214 . The sample consisted of 468 @entity1 , Caucasians, of Polish descent with @entity1479 10 diagnosis of @entity161 : 189 [51% males] were included in a @entity51 subgroup, 279 @entity1 [53% males] were included in a deficit subgroup. The control group consisted of 532 subjects, Caucasians, of Polish descent [51% males]. @entity1495 @entity15606 gene polymorphism was genotyped using the fluorescence resonance energy transfer (FRET) method and the Light Cycler System 2.0. RESULTS: The frequencies of genotypes and alleles did not differ between the @entity161 @entity1 and control group. The deficit and @entity51 @entity1 did not differ in terms of the genotype and allele frequencies. No differences were found in genotype and allele frequencies between the deficit @entity1 and the controls and between the @entity51 @entity1 and the controls. CONCLUSION: We found no evidence for the association between the functional @entity1495 @entity15606 gene polymorphism and deficit/ @entity51 subtypes of @entity161 .

title: Functional polymorphism of @entity1495 ( XXXX ) gene is not associated with @entity161 and with its deficit subtype.

answer: @entity1495 :: (4318,Gene) :: ['MMP9']


abstract: BACKGROUND: The deficit subtype of @entity161 is hypothesized to constitute a pathophysiologically distinct subgroup of @entity161 @entity1 suffering from enduring, @entity191 and various @entity51 . Matrix metalloproteinases (MMPs) are extracellularly acting endopeptidases the substrates of which are matrix and adhesion molecules. Recently, @entity1495 has been shown to be involved in various forms of synaptic plasticity, learning and memory consolidation. The primary aim of the present study was to evaluate associations between the functional @entity1495 @entity15606 gene polymorphism and the deficit and @entity51 subtypes of @entity161 . METHODS: The study was conducted between 2009 and 2012. Deficit @entity161 was diagnosed using the @entity214 . The sample consisted of 468 @entity1 , Caucasians, of Polish descent with @entity1479 10 diagnosis of @entity161 : 189 [51% males] were included in a @entity51 subgroup, 279 @entity1 [53% males] were included in a deficit subgroup. The control group consisted of 532 subjects, Caucasians, of Polish descent [51% males]. @entity1495 @entity15606 gene polymorphism was genotyped using the fluorescence resonance energy transfer (FRET) method and the Light Cycler System 2.0. RESULTS: The frequencies of genotypes and alleles did not differ between the @entity161 @entity1 and control group. The deficit and @entity51 @entity1 did not differ in terms of the genotype and allele frequencies. No differences were found in genotype and allele frequencies between the deficit @entity1 and the controls and between the @entity51 @entity1 and the controls. CONCLUSION: We found no evidence for the association between the functional @entity1495 @entity15606 gene polymorphism and deficit/ @entity51 subtypes of @entity161 .

title: Functional polymorphism of @entity1495 ( @entity1495 ) gene is not associated with XXXX and with its deficit subtype.

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']