abstract: We characterized the prevalence of pilus islets 1 ( @entity6417 ) and 2 ( @entity21912 ) and the clonality of @entity328 isolates taken from @entity1 with @entity697 ( @entity697 ) to study the association between pilus existence and @entity697 potential prior to pneumococcal conjugate vaccine and increased antimicrobial resistance. The study material consisted of 75 pneumococcal isolates cultured from the middle ear fluid and/or nasopharyngeal aspirate of 56 @entity1 with @entity697 in Finland during the period 1990-1992. Isolates were studied for antimicrobial susceptibility and were serotyped, genotyped by multilocus sequence typing (MLST), and tested for the presence of pneumococcal @entity6417 and @entity21912 genes. All isolates were susceptible to @entity114 , 14 different serotypes were found, and 20% of the isolates were positive for @entity6417 genes. @entity21912 genes were not found. MLST showed high heterogeneity: 52 @entity697 isolates belonged to 18 known clonal complexes (CC). @entity6417 was associated with serotypes 6A, 6B, and 9V, and genotype CC490. In the time prior to 7-valent pneumococcal conjugate vaccine (PCV7) and increased antimicrobial resistance, @entity697 isolates carried @entity6417 genes at a rather low prevalence. @entity21912 genes were not detected. @entity6417 was related to serotype rather than genotype. The importance of @entity6417 in @entity697 and its association with the spread of antimicrobial resistance requires further research.

title: Prevalence of pilus-encoding islets and clonality of pneumococcal isolates from @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute otitis media', 'pneumococcal AOM', 'AOM', 'AOM infections', 'AOM disease']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['penicillin']

entities_list: @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute otitis media']


abstract: We characterized the prevalence of pilus islets 1 ( @entity6417 ) and 2 ( @entity21912 ) and the clonality of @entity328 isolates taken from @entity1 with @entity697 ( @entity697 ) to study the association between pilus existence and @entity697 potential prior to pneumococcal conjugate vaccine and increased antimicrobial resistance. The study material consisted of 75 pneumococcal isolates cultured from the middle ear fluid and/or nasopharyngeal aspirate of 56 @entity1 with @entity697 in Finland during the period 1990-1992. Isolates were studied for antimicrobial susceptibility and were serotyped, genotyped by multilocus sequence typing (MLST), and tested for the presence of pneumococcal @entity6417 and @entity21912 genes. All isolates were susceptible to @entity114 , 14 different serotypes were found, and 20% of the isolates were positive for @entity6417 genes. @entity21912 genes were not found. MLST showed high heterogeneity: 52 @entity697 isolates belonged to 18 known clonal complexes (CC). @entity6417 was associated with serotypes 6A, 6B, and 9V, and genotype CC490. In the time prior to 7-valent pneumococcal conjugate vaccine (PCV7) and increased antimicrobial resistance, @entity697 isolates carried @entity6417 genes at a rather low prevalence. @entity21912 genes were not detected. @entity6417 was related to serotype rather than genotype. The importance of @entity6417 in @entity697 and its association with the spread of antimicrobial resistance requires further research.

title: Prevalence of pilus-encoding islets and clonality of pneumococcal isolates from XXXX with @entity697 .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: @entity8523 ( @entity8523 ) is an uncommon primary @entity358 . This @entity5 was first described by Barrett and Barnard in 1945. The @entity5 is composed of immature epithelial and mesenchymal tissues which may recapitulate early embryological lung development. Under the microscope, the globular component resembles immature bronchus and connective tissue as seen in embryonic lung. More than one hundred cases have been reported in the literature. @entity8523 is more frequent in older @entity1 and in males and tends to affect blacks at younger ages. Symptomatology varies from asymptomatic to symptoms of a non-specific @entity358 . Cough, hemoptysis, @entity1353 , @entity662 , @entity649 , @entity221 , @entity448 and @entity353 are the most common presenting features. The most common roentgenologic pattern is a well-demarcated @entity1897 , encapsulated by compression or atelectatic lung tissue, although in some cases there is a tendency to lobulation and cavitation. The size of the mass varies from a small peripheral nodule to a mass occupying the entire lobe or hemithorax. The treatment of choice has been surgical excision, radiation and, in selected cases, a combination of chemotherapy with radiation. The prognosis of this malignancy is poor; overall five-year survival is approximately 16 percent. No correlation has been established between histopathologic criteria and survival. The factors that indicate poor prognosis are @entity5 recurrence, @entity3 at initial presentation, @entity5 size over 5 cm and lymph node @entity3 . Liver, central nervous system and bones are the most frequent location of distant metastases. A rare case is presented of a @entity8523 with an upper lip @entity3 occurring in a paraplegic male. Diagnosis was confirmed by autopsy findings.(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity8523 presenting as a solitary lip XXXX : case report and review of the literature.

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity8523 :: ('MESH:D018202', 'Disease') :: ['pulmonary blastoma', 'PB', 'Pulmonary blastoma']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral lesion']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary disease', 'lung malignancy']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: @entity8523 ( @entity8523 ) is an uncommon primary @entity358 . This @entity5 was first described by Barrett and Barnard in 1945. The @entity5 is composed of immature epithelial and mesenchymal tissues which may recapitulate early embryological lung development. Under the microscope, the globular component resembles immature bronchus and connective tissue as seen in embryonic lung. More than one hundred cases have been reported in the literature. @entity8523 is more frequent in older @entity1 and in males and tends to affect blacks at younger ages. Symptomatology varies from asymptomatic to symptoms of a non-specific @entity358 . Cough, hemoptysis, @entity1353 , @entity662 , @entity649 , @entity221 , @entity448 and @entity353 are the most common presenting features. The most common roentgenologic pattern is a well-demarcated @entity1897 , encapsulated by compression or atelectatic lung tissue, although in some cases there is a tendency to lobulation and cavitation. The size of the mass varies from a small peripheral nodule to a mass occupying the entire lobe or hemithorax. The treatment of choice has been surgical excision, radiation and, in selected cases, a combination of chemotherapy with radiation. The prognosis of this malignancy is poor; overall five-year survival is approximately 16 percent. No correlation has been established between histopathologic criteria and survival. The factors that indicate poor prognosis are @entity5 recurrence, @entity3 at initial presentation, @entity5 size over 5 cm and lymph node @entity3 . Liver, central nervous system and bones are the most frequent location of distant metastases. A rare case is presented of a @entity8523 with an upper lip @entity3 occurring in a paraplegic male. Diagnosis was confirmed by autopsy findings.(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX presenting as a solitary lip @entity3 : case report and review of the literature.

answer: @entity8523 :: (MESH:D018202,Disease) :: ['Pulmonary blastoma']


abstract: BACKGROUND: @entity19597 ( @entity19597 ) regulates leukocyte tissue infiltration. Elevated serum soluble @entity19597 (sVAP-1) levels occur in certain diseases having an inflammatory component. We previously showed in @entity14 that sVAP-1 expression is significantly higher relative to controls, and this decreased expression is associated with poor prognosis and lymph node and liver @entity3 . However, sVAP-1 expression has not been described for @entity356 . This study determines the relationship between preoperative serum sVAP-1 levels and clinicopathological features and prognosis in @entity356 . METHODS: Preoperative serum was collected from 107 @entity356 @entity1 and 33 normal controls. sVAP-1 levels were assayed by enzyme-linked immunosorbent assay. RESULTS: The mean sVAP-1 level for @entity5 @entity1 was significantly higher relative to controls, and decreased with disease progression. @entity5 size, serosal invasion, lymph node @entity3 , peritoneal dissemination, and @entity2802 classification was significantly correlated with sVAP-1 level. sVAP-1 is also an independent predictive marker for lymph node @entity3 . @entity1 having low sVAP-1 levels had significantly poorer prognosis relative to @entity1 having elevated sVAP-1 in all or stages I-III @entity356 @entity1 , respectively. CONCLUSIONS: Low sVAP-1 levels are associated with poor prognosis in @entity356 . Determining sVAP-1 levels may be valuable for predicting prognosis and lymph node @entity3 .

title: Serum soluble XXXX is a valuable prognostic marker in @entity356 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Tumor']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

entities_list: @entity19597 :: ('8639', 'Gene') :: ['VAP-1', 'Vascular adhesion protein-1']

answer: @entity19597 :: (8639,Gene) :: ['vascular adhesion protein-1']


abstract: BACKGROUND: @entity19597 ( @entity19597 ) regulates leukocyte tissue infiltration. Elevated serum soluble @entity19597 (sVAP-1) levels occur in certain diseases having an inflammatory component. We previously showed in @entity14 that sVAP-1 expression is significantly higher relative to controls, and this decreased expression is associated with poor prognosis and lymph node and liver @entity3 . However, sVAP-1 expression has not been described for @entity356 . This study determines the relationship between preoperative serum sVAP-1 levels and clinicopathological features and prognosis in @entity356 . METHODS: Preoperative serum was collected from 107 @entity356 @entity1 and 33 normal controls. sVAP-1 levels were assayed by enzyme-linked immunosorbent assay. RESULTS: The mean sVAP-1 level for @entity5 @entity1 was significantly higher relative to controls, and decreased with disease progression. @entity5 size, serosal invasion, lymph node @entity3 , peritoneal dissemination, and @entity2802 classification was significantly correlated with sVAP-1 level. sVAP-1 is also an independent predictive marker for lymph node @entity3 . @entity1 having low sVAP-1 levels had significantly poorer prognosis relative to @entity1 having elevated sVAP-1 in all or stages I-III @entity356 @entity1 , respectively. CONCLUSIONS: Low sVAP-1 levels are associated with poor prognosis in @entity356 . Determining sVAP-1 levels may be valuable for predicting prognosis and lymph node @entity3 .

title: Serum soluble @entity19597 is a valuable prognostic marker in XXXX .

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: The burning of incense is an important source of indoor air pollution in Asia. We assessed the effect of long-term exposure to incense smoke on the body weight and levels of circulating @entity413 , @entity1674 , total @entity165 , HDL- @entity165 , insulin, adiponectin and @entity10672 in @entity35 albino @entity35 . Two groups of @entity35 were used. First group (n   =   12) was exposed daily to incense smoke for 4 months at the rate of 4   g   day(-1) in the exposure chamber. Another group of @entity35 (n   =   12), was used as non-exposed control. Blood samples were collected from all animals after 4, 8, 12 and 16 weeks of exposure. Serum @entity413 , @entity1674 , total @entity165 and HDL- @entity165 , LDL- @entity165 insulin, adiponectin and @entity10672 were measured. Our results showed that incense smoke exposure was associated with decreased @entity1017 and the adverse metabolic changes of increased @entity1674 and decreased HDL- @entity165 concentrations. Exposure to incense was also associated with a transient increase of @entity10672 levels. Taken together, these data suggest that incense smoke influences metabolism adversely in @entity35 . The effect of incense smoke on @entity1 health and the underlying mechanisms need to be studied further.

title: Long-term exposure to incense smoke alters metabolism in @entity35 albino XXXX .

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: The burning of incense is an important source of indoor air pollution in Asia. We assessed the effect of long-term exposure to incense smoke on the body weight and levels of circulating @entity413 , @entity1674 , total @entity165 , HDL- @entity165 , insulin, adiponectin and @entity10672 in @entity35 albino @entity35 . Two groups of @entity35 were used. First group (n   =   12) was exposed daily to incense smoke for 4 months at the rate of 4   g   day(-1) in the exposure chamber. Another group of @entity35 (n   =   12), was used as non-exposed control. Blood samples were collected from all animals after 4, 8, 12 and 16 weeks of exposure. Serum @entity413 , @entity1674 , total @entity165 and HDL- @entity165 , LDL- @entity165 insulin, adiponectin and @entity10672 were measured. Our results showed that incense smoke exposure was associated with decreased @entity1017 and the adverse metabolic changes of increased @entity1674 and decreased HDL- @entity165 concentrations. Exposure to incense was also associated with a transient increase of @entity10672 levels. Taken together, these data suggest that incense smoke influences metabolism adversely in @entity35 . The effect of incense smoke on @entity1 health and the underlying mechanisms need to be studied further.

title: Long-term exposure to incense smoke alters metabolism in XXXX albino @entity35 .

answer: @entity35 :: (10116,Species) :: ['Wistar']


abstract: BACKGROUND: The aim of this study was to assess the influence of @entity3 ( @entity3 ) on secondary @entity75 ( @entity75 ) following a frontal inter-hemispheric approach to midline @entity5 with accentuated preoperative brain shift phenomena. METHODS: We reviewed the results obtained in our department during the last 10 years in 24 treated @entity1 with such @entity5 . Some of these @entity1 underwent traditional surgical approaches using brain retractors (BR) and more recently alternative @entity3 including the creation of a narrow surgical corridor without brain retractors and the reinforcement and reinsertion from bridging veins. The @entity1 's @entity86 (consciousness recovery, @entity734 , ICU- @entity1 's stay and outcome) as well as the volume of the postoperative skull/brain space as a measurable indicator of @entity75 and the ventricular index were assessed in all cases. All data were compared using the Chi square test, the 2-tailed Pearson correlation and t-test. RESULTS: 24 @entity1 (11 operated with BR and 13 with @entity3 ) were analyzed. The comparison between both techniques revealed a significant reduction of the postoperatively assessed skull/brain space (P<0.001), time for consciousness recovery (P<0.05), @entity734 (P<0.001) and intensive care unit stay (P<0.005) for @entity1 treated with @entity3 . A significant correlation was observed between radiological and clinical data ( @entity734 , consciousness recovery and ICU stay) from P<0.01, P<0.05 and P<0.01 respectively. CONCLUSIONS: In our study @entity3 allow the @entity1 to recover consciousness in a shorter period of time, reducing the needs for prolonged mechanical ventilation and ICU stay. In these @entity1 , such clinical advantages are related with a radiologically assessed postoperative reduced @entity75 .

title: Minimally invasive technique reduces secondary @entity75 following a frontal interhemispheric approach to midline XXXX with accentuated brain shift phenomena.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain collapse', 'BC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative condition']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['minimal invasive techniques', 'MIT']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['respirator dependence']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumors']


abstract: BACKGROUND: The aim of this study was to assess the influence of @entity3 ( @entity3 ) on secondary @entity75 ( @entity75 ) following a frontal inter-hemispheric approach to midline @entity5 with accentuated preoperative brain shift phenomena. METHODS: We reviewed the results obtained in our department during the last 10 years in 24 treated @entity1 with such @entity5 . Some of these @entity1 underwent traditional surgical approaches using brain retractors (BR) and more recently alternative @entity3 including the creation of a narrow surgical corridor without brain retractors and the reinforcement and reinsertion from bridging veins. The @entity1 's @entity86 (consciousness recovery, @entity734 , ICU- @entity1 's stay and outcome) as well as the volume of the postoperative skull/brain space as a measurable indicator of @entity75 and the ventricular index were assessed in all cases. All data were compared using the Chi square test, the 2-tailed Pearson correlation and t-test. RESULTS: 24 @entity1 (11 operated with BR and 13 with @entity3 ) were analyzed. The comparison between both techniques revealed a significant reduction of the postoperatively assessed skull/brain space (P<0.001), time for consciousness recovery (P<0.05), @entity734 (P<0.001) and intensive care unit stay (P<0.005) for @entity1 treated with @entity3 . A significant correlation was observed between radiological and clinical data ( @entity734 , consciousness recovery and ICU stay) from P<0.01, P<0.05 and P<0.01 respectively. CONCLUSIONS: In our study @entity3 allow the @entity1 to recover consciousness in a shorter period of time, reducing the needs for prolonged mechanical ventilation and ICU stay. In these @entity1 , such clinical advantages are related with a radiologically assessed postoperative reduced @entity75 .

title: Minimally invasive technique reduces secondary XXXX following a frontal interhemispheric approach to midline @entity5 with accentuated brain shift phenomena.

answer: @entity75 :: (MESH:D001927,Disease) :: ['brain collapse']


abstract: This study aimed to investigate energy substrate utilisation and @entity1568 balance in low birthweight @entity1 receiving total parenteral nutrition during the first days of life, and in particular, to determine the effect of two different @entity413 intakes on @entity544 production. Twenty @entity1 (mean (SE) birthweight 1314 (65) g, mean (SE) gestation 30.9 (0.4) weeks) were recruited to the study. Immediately after birth they were randomised to a @entity1735 intake of 8 g/kg/day (5.5 mg/kg/minute) or 12 g/kg/day (8.3 mg/kg/minute). After 24 hours they were changed to the alternative regimen which was continued for a further 24 hours. Fat and protein intakes were kept constant throughout the study. Indirect calorimetry was performed during each of the regimens, urine was collected for urinary @entity1568 , and substrate utilisation calculated for 12 @entity1 . The @entity1735 utilisation rate was increased during the higher @entity1735 intake. Lipid utilisation rates were significantly different, with net lipid synthesis occurring during high @entity1735 intake. Protein utilisation rates were not influenced by the different @entity1735 intakes. The mean plasma @entity413 concentration was higher during the high @entity1735 intake but the mean highest and lowest values were not significantly different during the two study periods. A plasma @entity413 below 2.6 mmol/l was recorded more frequently during the low @entity413 intake (9/20 v 5/20). Capillary PCO2 values measured during high and low @entity413 intakes were similar (5.9 (0.2) v 6.2 (0.3) kPa. @entity544 production rates were increased during the higher @entity1735 intake but the differences were not significant. Similarly, there was no significant difference in the respiratory quotients (RQ), @entity26 consumption, or energy expenditure during the two study periods.

title: Low birthweight @entity1 and total parenteral nutrition immediately after birth. III. Randomised study of energy substrate utilisation, XXXX balance, and @entity544 production.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide', 'Carbon dioxide']

answer: @entity1568 :: (MESH:D009584,Chemical) :: ['nitrogen']


abstract: This study aimed to investigate energy substrate utilisation and @entity1568 balance in low birthweight @entity1 receiving total parenteral nutrition during the first days of life, and in particular, to determine the effect of two different @entity413 intakes on @entity544 production. Twenty @entity1 (mean (SE) birthweight 1314 (65) g, mean (SE) gestation 30.9 (0.4) weeks) were recruited to the study. Immediately after birth they were randomised to a @entity1735 intake of 8 g/kg/day (5.5 mg/kg/minute) or 12 g/kg/day (8.3 mg/kg/minute). After 24 hours they were changed to the alternative regimen which was continued for a further 24 hours. Fat and protein intakes were kept constant throughout the study. Indirect calorimetry was performed during each of the regimens, urine was collected for urinary @entity1568 , and substrate utilisation calculated for 12 @entity1 . The @entity1735 utilisation rate was increased during the higher @entity1735 intake. Lipid utilisation rates were significantly different, with net lipid synthesis occurring during high @entity1735 intake. Protein utilisation rates were not influenced by the different @entity1735 intakes. The mean plasma @entity413 concentration was higher during the high @entity1735 intake but the mean highest and lowest values were not significantly different during the two study periods. A plasma @entity413 below 2.6 mmol/l was recorded more frequently during the low @entity413 intake (9/20 v 5/20). Capillary PCO2 values measured during high and low @entity413 intakes were similar (5.9 (0.2) v 6.2 (0.3) kPa. @entity544 production rates were increased during the higher @entity1735 intake but the differences were not significant. Similarly, there was no significant difference in the respiratory quotients (RQ), @entity26 consumption, or energy expenditure during the two study periods.

title: Low birthweight @entity1 and total parenteral nutrition immediately after birth. III. Randomised study of energy substrate utilisation, @entity1568 balance, and XXXX production.

answer: @entity544 :: (MESH:D002245,Chemical) :: ['carbon dioxide']


abstract: This study aimed to investigate energy substrate utilisation and @entity1568 balance in low birthweight @entity1 receiving total parenteral nutrition during the first days of life, and in particular, to determine the effect of two different @entity413 intakes on @entity544 production. Twenty @entity1 (mean (SE) birthweight 1314 (65) g, mean (SE) gestation 30.9 (0.4) weeks) were recruited to the study. Immediately after birth they were randomised to a @entity1735 intake of 8 g/kg/day (5.5 mg/kg/minute) or 12 g/kg/day (8.3 mg/kg/minute). After 24 hours they were changed to the alternative regimen which was continued for a further 24 hours. Fat and protein intakes were kept constant throughout the study. Indirect calorimetry was performed during each of the regimens, urine was collected for urinary @entity1568 , and substrate utilisation calculated for 12 @entity1 . The @entity1735 utilisation rate was increased during the higher @entity1735 intake. Lipid utilisation rates were significantly different, with net lipid synthesis occurring during high @entity1735 intake. Protein utilisation rates were not influenced by the different @entity1735 intakes. The mean plasma @entity413 concentration was higher during the high @entity1735 intake but the mean highest and lowest values were not significantly different during the two study periods. A plasma @entity413 below 2.6 mmol/l was recorded more frequently during the low @entity413 intake (9/20 v 5/20). Capillary PCO2 values measured during high and low @entity413 intakes were similar (5.9 (0.2) v 6.2 (0.3) kPa. @entity544 production rates were increased during the higher @entity1735 intake but the differences were not significant. Similarly, there was no significant difference in the respiratory quotients (RQ), @entity26 consumption, or energy expenditure during the two study periods.

title: Low birthweight XXXX and total parenteral nutrition immediately after birth. III. Randomised study of energy substrate utilisation, @entity1568 balance, and @entity544 production.

answer: @entity1 :: (9606,Species) :: ['infants']


abstract: The case was a Japanese @entity1 of 62 years old. A bulbar mass attached to mitral valve anterior leaflet was discovered in an echocardiography within detailed examination of @entity741 accidentally. We diagnosed him as @entity741 and doubt of @entity4617 . We thought about the danger of future @entity887 , surgical treatment was decided. We dissected the @entity5 together with one chorda tendineae of mitral valve, and a performed aorta - coronary bypass surgery. We diagnosed the @entity5 as @entity1377 by pathological diagnosis. @entity1377 is extremely rare with 7-9% of @entity5 of heart primary. Most of the @entity1377 is incidentally discovered by echocardiography or autopsy. Or it is discovered for systemic @entity887 . The @entity5 is benign, but there is a problem to cause @entity887 . Therefore, when we discovered @entity1377 , surgical resection of the @entity5 is the first-line therapy. A problem on surgical therapy is the range of resection area. @entity1377 is @entity5 , but the pathological characteristic is still unidentified. Further epidemiological and pathological studies are necessary to determine the extent of surgical excision in associated with characteristics of @entity1377 .

title: A case report of XXXX attached to chorda tendineae of mitral valve.

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['Papillary fibroelastoma', 'papillary fibroelastoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumor']

entities_list: @entity4617 :: ('MESH:D006338', 'Disease') :: ['heart tumor']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

answer: @entity1377 :: (MESH:D002291,Disease) :: ['papillary fibroelastoma']


abstract: BACKGROUND: @entity0 ( @entity0 ) carries an ominous prognosis. Before 1988, @entity1 with @entity0 at our institution were treated with neoadjuvant @entity786 , @entity1499 , and @entity1487 (CMF) with or without @entity1891 and @entity229 (CMF/VP). After 1988, @entity1 with @entity0 were treated with @entity786 , @entity632 , and @entity1487 (FAC). This study compares these two regimens with regard to response and survival. METHODS: The records of all @entity1 presenting between January 1973 and December 1991 with a stage IIIB (T4d, any N, MO) @entity0 with proven dermal lymphatic invasion by @entity5 cells were reviewed retrospectively. RESULTS: The study comprised 38 @entity1 ; 28 received CMF (22 CMF, 6 CMF/VP), and 10 received FAC. The overall response rate to induction chemotherapy in the CMF/VP group was 57% (40% PR, 17% CR), and 100% (60% PR, 40% CR) in the FAC group. The median overall survival for @entity1 receiving CMF/VP was 18 months compared with 30 months for @entity1 receiving FAC (p = 0.02). The median disease-free survivals for the CMF/VP and FAC groups were 6 and 24 months, respectively (p < 0.001). When comparing responders and nonresponders with CMF/VP induction therapy, the responders had a significantly longer overall median survival (24 versus 10 months) (p < 0.001) and disease-free median survival (8 versus 2 months) (p < 0.001). All of the five @entity1 remaining alive received FAC with 80% (four of five) having a complete response. These four @entity1 subsequently underwent mastectomy and radiation. CONCLUSION: This study suggests that a @entity632 -containing chemotherapy regimen improves overall and disease-free median survivals when compared with the previously used CMF combination in the treatment of @entity0 . A favorable response to induction chemotherapy also appeared to be associated with an improved survival.

title: Therapy for @entity0 : impact of XXXX -based therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'Inflammatory breast cancer', 'IBC']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity632 :: (MESH:D004317,Chemical) :: ['doxorubicin']


abstract: BACKGROUND: @entity0 ( @entity0 ) carries an ominous prognosis. Before 1988, @entity1 with @entity0 at our institution were treated with neoadjuvant @entity786 , @entity1499 , and @entity1487 (CMF) with or without @entity1891 and @entity229 (CMF/VP). After 1988, @entity1 with @entity0 were treated with @entity786 , @entity632 , and @entity1487 (FAC). This study compares these two regimens with regard to response and survival. METHODS: The records of all @entity1 presenting between January 1973 and December 1991 with a stage IIIB (T4d, any N, MO) @entity0 with proven dermal lymphatic invasion by @entity5 cells were reviewed retrospectively. RESULTS: The study comprised 38 @entity1 ; 28 received CMF (22 CMF, 6 CMF/VP), and 10 received FAC. The overall response rate to induction chemotherapy in the CMF/VP group was 57% (40% PR, 17% CR), and 100% (60% PR, 40% CR) in the FAC group. The median overall survival for @entity1 receiving CMF/VP was 18 months compared with 30 months for @entity1 receiving FAC (p = 0.02). The median disease-free survivals for the CMF/VP and FAC groups were 6 and 24 months, respectively (p < 0.001). When comparing responders and nonresponders with CMF/VP induction therapy, the responders had a significantly longer overall median survival (24 versus 10 months) (p < 0.001) and disease-free median survival (8 versus 2 months) (p < 0.001). All of the five @entity1 remaining alive received FAC with 80% (four of five) having a complete response. These four @entity1 subsequently underwent mastectomy and radiation. CONCLUSION: This study suggests that a @entity632 -containing chemotherapy regimen improves overall and disease-free median survivals when compared with the previously used CMF combination in the treatment of @entity0 . A favorable response to induction chemotherapy also appeared to be associated with an improved survival.

title: Therapy for XXXX : impact of @entity632 -based therapy.

answer: @entity0 :: (MESH:D001943,Disease) :: ['inflammatory breast cancer']


abstract: Several new studies have indicated that an active approach to @entity1 with @entity1643 (LBP) seems effective. Some of these studies emphasize the importance of dealing with the @entity1 's total situation in comprehensive multidisciplinary programs--the bio-psycho-social model. However, these programs are expensive. The aim of this study was to evaluate the rehabilitation outcome from three different active programs in terms of: (1) return-to-work rate, (2) days of sick leave, (3) health-care contacts, (4) @entity158 and disability scores, and (5) staying physically active. The subjects included 132 @entity1 randomized to the study, of whom 123 started one of the treatment programs. They had all had at least 6 months of chronic LBP. The @entity1 were randomized into one of three programs: group 1--a full-time, intensive 3-week multidisciplinary program, including active physical and ergonomic training and @entity158 management, followed by 1 day weekly for the subsequent 3 weeks; group 2--active physical training, twice a week for 6 weeks, for a total of 24h; group 3-- @entity158 management combined with active physical training, twice a week for 6 weeks, also for a total of 24h. The results presented here are based on data collected 4 months following treatment, which shows an 86% response rate. The initial examination and the follow-up evaluation were performed by a blinded observer. The results show that 4 months after treatment, the intensive multidisciplinary program is superior to the less intensive programs in terms of return-to-work rate, health-care contacts, @entity158 and disability scores, and staying physically active.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Active treatment programs for @entity1 with XXXX : a prospective, randomized, observer-blinded study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['chronic disabling low back pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'psychological pain']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['chronic low back pain']


abstract: Several new studies have indicated that an active approach to @entity1 with @entity1643 (LBP) seems effective. Some of these studies emphasize the importance of dealing with the @entity1 's total situation in comprehensive multidisciplinary programs--the bio-psycho-social model. However, these programs are expensive. The aim of this study was to evaluate the rehabilitation outcome from three different active programs in terms of: (1) return-to-work rate, (2) days of sick leave, (3) health-care contacts, (4) @entity158 and disability scores, and (5) staying physically active. The subjects included 132 @entity1 randomized to the study, of whom 123 started one of the treatment programs. They had all had at least 6 months of chronic LBP. The @entity1 were randomized into one of three programs: group 1--a full-time, intensive 3-week multidisciplinary program, including active physical and ergonomic training and @entity158 management, followed by 1 day weekly for the subsequent 3 weeks; group 2--active physical training, twice a week for 6 weeks, for a total of 24h; group 3-- @entity158 management combined with active physical training, twice a week for 6 weeks, also for a total of 24h. The results presented here are based on data collected 4 months following treatment, which shows an 86% response rate. The initial examination and the follow-up evaluation were performed by a blinded observer. The results show that 4 months after treatment, the intensive multidisciplinary program is superior to the less intensive programs in terms of return-to-work rate, health-care contacts, @entity158 and disability scores, and staying physically active.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Active treatment programs for XXXX with @entity1643 : a prospective, randomized, observer-blinded study.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION: The "Hispanic Paradox" refers to the epidemiological finding that Hispanics in the US have better health outcomes than the average population despite what their aggregate socioeconomic determinants would predict. OBJECTIVES: The aim of this study was to evaluate obstetric outcomes for a multiethnic population with @entity101 diseases. METHODS: We performed a retrospective review of parturients with @entity101 disease delivering at Duke University Medical Center in 2005-2007. We analyzed maternal sociodemographic characteristics and ethnic differences in @entity101 disease types using Chi Square. We assessed the role of race and ethnicity on maternal and neonatal outcomes through a series of logistic regression analyses. RESULTS: Nine thousand eight hundred and thirteen @entity1 delivered during the study period, and 9% had @entity101 diseases in pregnancy. There were significant racial and ethnic differences in presentation (Chi-square=39.11, p<.001) with gestational @entity101 more common in Whites, chronic @entity101 in African Americans, and mild @entity1468 in Hispanics. The overall incidence of @entity1468 was lower in Hispanics. However, severe @entity1468 rates were equal across groups. Hispanics were more likely to be uninsured, younger, enter prenatal care later, and least likely to complete high school. There was no significant difference in smoking or parity. Stratified analyses by ethnicity showed that the relationship between severe @entity1468 and comorbidities (IUGR, LBW, ICN admission) were least pronounced in Hispanics and strongest in African American @entity1 . CONCLUSION: Despite similar rates of severe @entity1468 and adverse sociodemographic characteristics, Hispanic @entity1 with severe @entity1468 had better pregnancy outcomes than African-American or White @entity1 with the disease.

title: OS028. XXXX disease in pregnancy: An examination of ethnic differences and the Hispanic paradox.

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive', 'hypertension']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertensive']


abstract: The survival rate for @entity1 with @entity11 is poor. We describe the results of a prospective study using concomitant chemoradiotherapy, neutron boost, and adjuvant chemotherapy for @entity1 with @entity11 . Forty-two @entity1 with @entity816 ( @entity816 ) and @entity463 ( @entity463 ) were treated with postoperative photon radiation 45 Gy/25 fraction (fxs) with concomitant continuous intravenous infusion of @entity1487 at 300 mg/m2/day x 5 days and @entity1862 0.5 g orally every 12 hr for 6 days for 5 consecutive weeks, followed by a neutron boost of 450 N cGy/6 fxs delivered twice weekly. Adjuvant chemotherapy with @entity4174 , @entity11770 , and @entity1891 ( @entity1485 ) was given up to 1 year or until @entity5 progression. Thirty-four @entity1 (81%) had @entity463 and 8 @entity1 (19%) had @entity816 . Sixteen @entity1 (38%) were ineligible for the neutron boost because of large @entity5 or poor performance status and instead received a photon boost with concomitant chemotherapy for a total dose of 60-65 Gy to the @entity5 . The overall median survival is 68 weeks at a median follow-up of 203 weeks (range 166-302 weeks for the 11 @entity1 remaining alive); 7/8 @entity1 with @entity816 are alive, 2 of these with progressive disease. For @entity816 the median survival is not reached at a median follow-up of 203 weeks (range 166-302 weeks for the 7 @entity1 alive with @entity816 ). Time to @entity5 progression for the 1 dead @entity1 with @entity816 was 35 weeks and the other 2 @entity1 failed at 171 weeks and 179 weeks following treatment. The median survival for the 34 @entity1 with @entity463 was 62 weeks; 4/34 @entity1 with @entity463 are alive at 285, 238, 216, and 206 weeks. Multivariate survival analysis in the 34 @entity1 with @entity463 revealed age and Karnofsky performance status as important prognostic factors. Extent of surgery and neutrons did not affect survival. Concomitant chemoradiotherapy was well tolerated by all @entity1 . The only toxicities observed were @entity33 < or = grade II in 3 @entity1 (7%) and mild myelosuppression in 1 @entity1 (2.4%). Adjuvant @entity1485 was well tolerated. Continuous concomitant chemoradiotherapy was well tolerated by all @entity1 with acceptable side effects. The survival rate for the @entity1 with @entity463 suggests no significant impact on the prognosis for these @entity1 . @entity1 with @entity816 did well; however, the @entity1 numbers are small.

title: Concomitant chemoradiotherapy, neutron boost, and adjuvant chemotherapy for XXXX and @entity463 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity4174 :: ('MESH:D011344', 'Chemical') :: ['procarbazine']

entities_list: @entity1862 :: ('MESH:D006918', 'Chemical') :: ['hydroxyurea']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['malignant gliomas']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytoma', 'AA']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma multiforme', 'GBM']

answer: @entity816 :: (MESH:D001254,Disease) :: ['anaplastic astrocytoma']


abstract: The survival rate for @entity1 with @entity11 is poor. We describe the results of a prospective study using concomitant chemoradiotherapy, neutron boost, and adjuvant chemotherapy for @entity1 with @entity11 . Forty-two @entity1 with @entity816 ( @entity816 ) and @entity463 ( @entity463 ) were treated with postoperative photon radiation 45 Gy/25 fraction (fxs) with concomitant continuous intravenous infusion of @entity1487 at 300 mg/m2/day x 5 days and @entity1862 0.5 g orally every 12 hr for 6 days for 5 consecutive weeks, followed by a neutron boost of 450 N cGy/6 fxs delivered twice weekly. Adjuvant chemotherapy with @entity4174 , @entity11770 , and @entity1891 ( @entity1485 ) was given up to 1 year or until @entity5 progression. Thirty-four @entity1 (81%) had @entity463 and 8 @entity1 (19%) had @entity816 . Sixteen @entity1 (38%) were ineligible for the neutron boost because of large @entity5 or poor performance status and instead received a photon boost with concomitant chemotherapy for a total dose of 60-65 Gy to the @entity5 . The overall median survival is 68 weeks at a median follow-up of 203 weeks (range 166-302 weeks for the 11 @entity1 remaining alive); 7/8 @entity1 with @entity816 are alive, 2 of these with progressive disease. For @entity816 the median survival is not reached at a median follow-up of 203 weeks (range 166-302 weeks for the 7 @entity1 alive with @entity816 ). Time to @entity5 progression for the 1 dead @entity1 with @entity816 was 35 weeks and the other 2 @entity1 failed at 171 weeks and 179 weeks following treatment. The median survival for the 34 @entity1 with @entity463 was 62 weeks; 4/34 @entity1 with @entity463 are alive at 285, 238, 216, and 206 weeks. Multivariate survival analysis in the 34 @entity1 with @entity463 revealed age and Karnofsky performance status as important prognostic factors. Extent of surgery and neutrons did not affect survival. Concomitant chemoradiotherapy was well tolerated by all @entity1 . The only toxicities observed were @entity33 < or = grade II in 3 @entity1 (7%) and mild myelosuppression in 1 @entity1 (2.4%). Adjuvant @entity1485 was well tolerated. Continuous concomitant chemoradiotherapy was well tolerated by all @entity1 with acceptable side effects. The survival rate for the @entity1 with @entity463 suggests no significant impact on the prognosis for these @entity1 . @entity1 with @entity816 did well; however, the @entity1 numbers are small.

title: Concomitant chemoradiotherapy, neutron boost, and adjuvant chemotherapy for @entity816 and XXXX .

answer: @entity463 :: (MESH:D005909,Disease) :: ['glioblastoma multiforme']


abstract: BACKGROUND AND PURPOSE: @entity7244 ( @entity7244 ) is a common cause of @entity385 in Asians, whereas whites tend to have more @entity85 . @entity6511 ( @entity6511 ) has been associated with @entity385 by a large amount of work. However, there are few studies focusing on the relationship of @entity6511 and asymptomatic @entity7244 or extracranial @entity2791 (ECAS). Wehereby sought to explore the relationship of @entity6511 and @entity7244 , ECAS and concurrent @entity850 in @entity64 -free @entity101 @entity1 in Chinese population. METHODS: All the subjects were evaluated for the presence and severity of @entity7244 and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. @entity6511 mass was measured by enzyme linked immunoassay. The association of @entity6511 and @entity455 was analyzed through multivariate logistic regression. RESULTS: Among 414 @entity1 , 163 (39.4%) had no @entity7244 or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had @entity7244 only and 77 (18.6%) had concurrent extraintracranial @entity850 . @entity6511 mass was significantly associated with isolated @entity7244 (OR: 2.3; 95% CI: 1.14-4.64), and concurrent @entity850 (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). @entity6511 mass was also associated with moderate to severe @entity7244 no matter how was the ECAS. Moreover, @entity1 with higher @entity6511 mass showed more sever @entity7244 and had more @entity1504 . CONCLUSION: This study revealed the association of @entity6511 mass with @entity7244 in @entity64 -free @entity101 @entity1 in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of @entity6511 on the asymptomatic @entity7244 .

title: Association of @entity6511 Mass and Aysmptomatic Intracranial and Extracranial XXXX in @entity101 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular stenosis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity6511 :: ('7941', 'Gene') :: ['Lipoprotein-associated phospholipase A2', 'Lp-PLA2']

entities_list: @entity7244 :: ('MESH:D020765', 'Disease') :: ['ICAS', 'Intracranial arterial stenosis']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['arterial stenosis']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial arterial lesions']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['extracranial lesions']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity2791 :: (MESH:D012078,Disease) :: ['Arterial Stenosis']


abstract: BACKGROUND AND PURPOSE: @entity7244 ( @entity7244 ) is a common cause of @entity385 in Asians, whereas whites tend to have more @entity85 . @entity6511 ( @entity6511 ) has been associated with @entity385 by a large amount of work. However, there are few studies focusing on the relationship of @entity6511 and asymptomatic @entity7244 or extracranial @entity2791 (ECAS). Wehereby sought to explore the relationship of @entity6511 and @entity7244 , ECAS and concurrent @entity850 in @entity64 -free @entity101 @entity1 in Chinese population. METHODS: All the subjects were evaluated for the presence and severity of @entity7244 and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. @entity6511 mass was measured by enzyme linked immunoassay. The association of @entity6511 and @entity455 was analyzed through multivariate logistic regression. RESULTS: Among 414 @entity1 , 163 (39.4%) had no @entity7244 or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had @entity7244 only and 77 (18.6%) had concurrent extraintracranial @entity850 . @entity6511 mass was significantly associated with isolated @entity7244 (OR: 2.3; 95% CI: 1.14-4.64), and concurrent @entity850 (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). @entity6511 mass was also associated with moderate to severe @entity7244 no matter how was the ECAS. Moreover, @entity1 with higher @entity6511 mass showed more sever @entity7244 and had more @entity1504 . CONCLUSION: This study revealed the association of @entity6511 mass with @entity7244 in @entity64 -free @entity101 @entity1 in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of @entity6511 on the asymptomatic @entity7244 .

title: Association of XXXX Mass and Aysmptomatic Intracranial and Extracranial @entity2791 in @entity101 @entity1 .

answer: @entity6511 :: (7941,Gene) :: ['Lp-PLA2']


abstract: BACKGROUND AND PURPOSE: @entity7244 ( @entity7244 ) is a common cause of @entity385 in Asians, whereas whites tend to have more @entity85 . @entity6511 ( @entity6511 ) has been associated with @entity385 by a large amount of work. However, there are few studies focusing on the relationship of @entity6511 and asymptomatic @entity7244 or extracranial @entity2791 (ECAS). Wehereby sought to explore the relationship of @entity6511 and @entity7244 , ECAS and concurrent @entity850 in @entity64 -free @entity101 @entity1 in Chinese population. METHODS: All the subjects were evaluated for the presence and severity of @entity7244 and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. @entity6511 mass was measured by enzyme linked immunoassay. The association of @entity6511 and @entity455 was analyzed through multivariate logistic regression. RESULTS: Among 414 @entity1 , 163 (39.4%) had no @entity7244 or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had @entity7244 only and 77 (18.6%) had concurrent extraintracranial @entity850 . @entity6511 mass was significantly associated with isolated @entity7244 (OR: 2.3; 95% CI: 1.14-4.64), and concurrent @entity850 (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). @entity6511 mass was also associated with moderate to severe @entity7244 no matter how was the ECAS. Moreover, @entity1 with higher @entity6511 mass showed more sever @entity7244 and had more @entity1504 . CONCLUSION: This study revealed the association of @entity6511 mass with @entity7244 in @entity64 -free @entity101 @entity1 in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of @entity6511 on the asymptomatic @entity7244 .

title: Association of @entity6511 Mass and Aysmptomatic Intracranial and Extracranial @entity2791 in XXXX @entity1 .

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertension']


abstract: BACKGROUND AND PURPOSE: @entity7244 ( @entity7244 ) is a common cause of @entity385 in Asians, whereas whites tend to have more @entity85 . @entity6511 ( @entity6511 ) has been associated with @entity385 by a large amount of work. However, there are few studies focusing on the relationship of @entity6511 and asymptomatic @entity7244 or extracranial @entity2791 (ECAS). Wehereby sought to explore the relationship of @entity6511 and @entity7244 , ECAS and concurrent @entity850 in @entity64 -free @entity101 @entity1 in Chinese population. METHODS: All the subjects were evaluated for the presence and severity of @entity7244 and ECAS through computerized tomographic angiography (CTA) covered the whole brain down to the level of aortic arch. @entity6511 mass was measured by enzyme linked immunoassay. The association of @entity6511 and @entity455 was analyzed through multivariate logistic regression. RESULTS: Among 414 @entity1 , 163 (39.4%) had no @entity7244 or ECAS, 63 (15.2%) had ECAS only, 111 (26.8%) had @entity7244 only and 77 (18.6%) had concurrent extraintracranial @entity850 . @entity6511 mass was significantly associated with isolated @entity7244 (OR: 2.3; 95% CI: 1.14-4.64), and concurrent @entity850 (OR: 3.93; 95% CI: 1.62-9.51), but was not related to isolated ECAS (OR: 1.54; 95% CI: 0.68-3.48). @entity6511 mass was also associated with moderate to severe @entity7244 no matter how was the ECAS. Moreover, @entity1 with higher @entity6511 mass showed more sever @entity7244 and had more @entity1504 . CONCLUSION: This study revealed the association of @entity6511 mass with @entity7244 in @entity64 -free @entity101 @entity1 in Chinese population. The further long-term cohort study was warranted to elucidate the concrete effect of @entity6511 on the asymptomatic @entity7244 .

title: Association of @entity6511 Mass and Aysmptomatic Intracranial and Extracranial @entity2791 in @entity101 XXXX .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: 1. Measurements were made of @entity1 placental @entity934 ( @entity1617 ) content and release into maternal and fetal circulations from placenta obtained before, during and after labours of both spontaneous and induced onsets. @entity1617 content was determined in ex vivo placental biopsies using a radio-enzymatic assay. @entity1617 release was determined by bioassay of the effluent from placental lobules perfused with amniotic fluid-like Kreb's containing @entity2607 (2.4 mumol/l). 2. @entity1617 content of placentae obtained after labour (spontaneous onset of labour, normal vaginal delivery) and during labour (spontaneous onset of labour, Caesarean section delivery) was significantly less than before labour (no labour onset, Caesarean section delivery). 3. Mean @entity1617 output into maternal vessels 1.5-4.0 h after commencement of perfusion of placentae obtained after labour (spontaneous onset of labour, normal vaginal delivery) was significantly less than from those obtained before labour (no labour onset, Caesarean section delivery). No differences were found in @entity1617 output into fetal vessels of placentae obtained before, during or after labour. 4. These results suggest a role for placental @entity1617 in the events of @entity1 labour. The decrease in @entity1617 content and maternal vascular release in placenta obtained after labour is consistent with a depletion of placental @entity1617 during labour which may indicate @entity1617 release at this time. The lack of any significant change in fetal vascular release of @entity1617 in placenta obtained before, during or after labour, raises the possibility of different roles for @entity1617 released into fetal and maternal vasculature.

title: @entity1 placental XXXX content and release at parturition.

entities_list: @entity2607 :: ('MESH:D010830', 'Chemical') :: ['physostigmine']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity934 :: (MESH:D000109,Chemical) :: ['acetylcholine']


abstract: 1. Measurements were made of @entity1 placental @entity934 ( @entity1617 ) content and release into maternal and fetal circulations from placenta obtained before, during and after labours of both spontaneous and induced onsets. @entity1617 content was determined in ex vivo placental biopsies using a radio-enzymatic assay. @entity1617 release was determined by bioassay of the effluent from placental lobules perfused with amniotic fluid-like Kreb's containing @entity2607 (2.4 mumol/l). 2. @entity1617 content of placentae obtained after labour (spontaneous onset of labour, normal vaginal delivery) and during labour (spontaneous onset of labour, Caesarean section delivery) was significantly less than before labour (no labour onset, Caesarean section delivery). 3. Mean @entity1617 output into maternal vessels 1.5-4.0 h after commencement of perfusion of placentae obtained after labour (spontaneous onset of labour, normal vaginal delivery) was significantly less than from those obtained before labour (no labour onset, Caesarean section delivery). No differences were found in @entity1617 output into fetal vessels of placentae obtained before, during or after labour. 4. These results suggest a role for placental @entity1617 in the events of @entity1 labour. The decrease in @entity1617 content and maternal vascular release in placenta obtained after labour is consistent with a depletion of placental @entity1617 during labour which may indicate @entity1617 release at this time. The lack of any significant change in fetal vascular release of @entity1617 in placenta obtained before, during or after labour, raises the possibility of different roles for @entity1617 released into fetal and maternal vasculature.

title: XXXX placental @entity934 content and release at parturition.

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: Just like every other part of the organism, the skin ages as a result of the passage of time. That process is called chronologic or intrinsic aging. However, skin is also exposed to external insults, such as UV radiation, which is the most influential extrinsic factor in skin aging, causing so called photoaging or extrinsic skin aging. Photoaging is a cumulative process which depends on the degree of UV exposure and the skin type. It is much more visible in individuals with skin types I and II and, less prominent in dark-skinned population. Chronic sun exposure can result in numerous changes in @entity1 skin, particularly on the face, nape, and arms. Keratinocytes, melanocytes, fibroblasts, and endothelial cells are altered by UV radiation. Therefore, changes in photoaging include wrinkling, @entity2652 , @entity2517 , irregular pigmentation, @entity8721 , and the development of @entity1489 . In the last decades, important progress has been made in understanding molecular mechanisms of photoaging. It is a complex process in which UV radiation has effects on numerous molecular processes that damage the skin, especially connective tissue of the skin. These processes include cell surface receptors, certain signal transduction pathways, transcription factors and, various enzymes involved in the synthesis and degradation of the dermal elements. Initial process in the activation of this process is UV-induced generation of the reactive @entity26 species, which can also directly damage cell's DNA, membrane and proteins. Most of alterations found on the photoaged skin had formerly been considered to be caused by UVB wavelengths. However, a number of recent studies have demonstrated that UVA can also cause burning, @entity2652 , and @entity1489 .

title: Skin changes in the elderly XXXX --how strong is the influence of the UV radiation on skin aging?

entities_list: @entity8721 :: ('MESH:D013684', 'Disease') :: ['telangiectases']

entities_list: @entity2652 :: ('MESH:D005148', 'Disease') :: ['elastosis']

entities_list: @entity2517 :: ('MESH:D055623', 'Disease') :: ['actinic keratoses']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['malignant skin tumours', 'skin cancer']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: BACKGROUND: To assess the feasibility, @entity137 , and outcome of prostate hemi-irradiation with a high-dose-rate brachytherapy (HDR-BT) boost for @entity1 presumed to @entity263 in a single lobe. METHODS: After 3D conformal external radiotherapy (3DCRT) to 64-64.4   Gy, 77 @entity1 with non-metastatic locally aggressive @entity263 have been treated from 2000 to 2004, with HDR-BT using temporary open MRI-guided (192) Ir implants, to escalate the dose in the boost region. Twenty @entity1 (26%) had one lobe involvement (i.e., one sided endorectal MRI, rectal examination, and biopsies) and were boosted to one side of the gland only. A dose of 12, 14, and 16   Gy in two fractions was delivered to 5, 6, and 9 @entity1 , respectively. RESULTS: After a median follow-up 69 months, no differences in late rectal @entity137 were observed between the unilaterally and bilaterally irradiated cohorts. Although, grade 2 late urinary @entity137 was worse in the hemi-irradiated group (P = 0.03), severe grade >= 3 late urinary @entity137 at 5 years was not different: 10% versus 8.8% in the unilaterally and bilaterally irradiated cohorts, respectively. Grade 4 late urinary @entity137 , however, was exclusively observed in @entity1 @entity1315 (5/57, 8.8%). Five-year biochemical relapse-free survival was 79.7% versus 70.5% for the unilateral and bilateral boost groups, respectively (P = 0.99). CONCLUSION: Prostate hemi-irradiation with a HDR-BT boost to the dominant @entity5 region may be considered when rectal examination, MRI, and biopsies suggest one lobe involvement. Nevertheless, strict dosimetric optimization is needed in order to further reduce the risk of late severe @entity137 .

title: High-dose-rate brachytherapy boost to the @entity263 region: hemi-irradiation of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['harbor dominant intra-prostatic tumors', 'prostate cancer']

entities_list: @entity1315 :: ('MESH:D004833', 'Disease') :: ['boosted to both lobes']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: BACKGROUND: To assess the feasibility, @entity137 , and outcome of prostate hemi-irradiation with a high-dose-rate brachytherapy (HDR-BT) boost for @entity1 presumed to @entity263 in a single lobe. METHODS: After 3D conformal external radiotherapy (3DCRT) to 64-64.4   Gy, 77 @entity1 with non-metastatic locally aggressive @entity263 have been treated from 2000 to 2004, with HDR-BT using temporary open MRI-guided (192) Ir implants, to escalate the dose in the boost region. Twenty @entity1 (26%) had one lobe involvement (i.e., one sided endorectal MRI, rectal examination, and biopsies) and were boosted to one side of the gland only. A dose of 12, 14, and 16   Gy in two fractions was delivered to 5, 6, and 9 @entity1 , respectively. RESULTS: After a median follow-up 69 months, no differences in late rectal @entity137 were observed between the unilaterally and bilaterally irradiated cohorts. Although, grade 2 late urinary @entity137 was worse in the hemi-irradiated group (P = 0.03), severe grade >= 3 late urinary @entity137 at 5 years was not different: 10% versus 8.8% in the unilaterally and bilaterally irradiated cohorts, respectively. Grade 4 late urinary @entity137 , however, was exclusively observed in @entity1 @entity1315 (5/57, 8.8%). Five-year biochemical relapse-free survival was 79.7% versus 70.5% for the unilateral and bilateral boost groups, respectively (P = 0.99). CONCLUSION: Prostate hemi-irradiation with a HDR-BT boost to the dominant @entity5 region may be considered when rectal examination, MRI, and biopsies suggest one lobe involvement. Nevertheless, strict dosimetric optimization is needed in order to further reduce the risk of late severe @entity137 .

title: High-dose-rate brachytherapy boost to the XXXX region: hemi-irradiation of @entity263 .

answer: @entity263 :: (MESH:D011471,Disease) :: ['dominant intra-prostatic tumor']


abstract: UNASSIGNED: @entity5 occurring in the retrorectal space are heterogeneous and uncommon. Multiple embryologie remnants derived from a variety of tissues are found in this space and this explains the heterogeneous pathology of cysts and @entity5 that arise in retrorectal space. @entity45 are rare in adults. Most of the lesions are benign. The cysts may be unilocular or multilocular. They are often asymptomatic. These @entity5 pose a diagnostic and therapeutic interest. @entity4890 are classified as a type of developmental cysts. We report the case of a 57-year-old @entity1 who presented with a painless mass posterior of the anus. Imaging studies showed a @entity45 (65 * 100 * 60 mm) in the retrorectal space. The @entity1 underwent surgery via a posterior approach. Histological study revealed a @entity4890 . A review of literature of this rare @entity5 is performed. KEY WORDS: Presacral cyst, Retrorectal epidermal cyst, @entity5 .

title: Retrorectal XXXX in a adult female Case report and review of literature.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'Retrorectal tumours', 'tumors']

entities_list: @entity4890 :: ('MESH:D004814', 'Disease') :: ['Presacral epidermoid cysts', 'epidermoid cyst']

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['Presacral cysts', 'multilocular cyst']

answer: @entity45 :: (MESH:D010181,Disease) :: ['multilocular cyst']


abstract: OBJECTIVES: In elderly @entity1 with @entity955 ( @entity955 ), medial temporal lobe (MTL) @entity194 and @entity62 ( @entity62 ) may account for the @entity73 . Though a combination therapy of statins with @entity165 lowering agents like @entity3709 may be beneficial in @entity1 with @entity955 , its effects on MTL structure and @entity62 remains unknown. METHODS: A parallel group double-blinded randomized trial was performed during 1 year whereby elderly @entity64 -free @entity955 @entity1 either received placebo or @entity2993 and @entity3709 on top oral anticoagulation therapy. Neuropsychological performance and inflammatory markers in the blood were assessed at baseline and 1 year later together with amygdala and hippocampal volume as well as @entity62 . RESULTS: Sixty-three @entity1 were assessed for eligibility, but 29 @entity1 had to be excluded so that 34 @entity1 were randomized to both groups. In the treatment group, the systemic level of inflammation was significantly decreased after 1 year and an improvement in cognitive speed as well as short- and long-term memory was observed. While there was no significant difference in MTL volume at baseline, the placebo group exhibited more @entity194 for right amygdala and left hippocampus at follow-up. Finally, descriptive data showed a slight decline of @entity62 volume in the treatment group. CONCLUSIONS: In spite of limitations due to small sample size, our data suggest that intensive @entity165 lowering therapy in @entity955 @entity1 may slow @entity73 and @entity194 of the MTL. Though these results have to be replicated in a larger sample, they offer potential for future interventions.

title: One-year @entity165 lowering treatment reduces medial temporal lobe @entity194 and memory decline in XXXX -free elderly with @entity955 : evidence from a parallel group randomized trial.

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline']

entities_list: @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin']

entities_list: @entity3709 :: ('MESH:C108606', 'Chemical') :: ['ezetimibe']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['white matter lesions', 'WML']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: OBJECTIVES: In elderly @entity1 with @entity955 ( @entity955 ), medial temporal lobe (MTL) @entity194 and @entity62 ( @entity62 ) may account for the @entity73 . Though a combination therapy of statins with @entity165 lowering agents like @entity3709 may be beneficial in @entity1 with @entity955 , its effects on MTL structure and @entity62 remains unknown. METHODS: A parallel group double-blinded randomized trial was performed during 1 year whereby elderly @entity64 -free @entity955 @entity1 either received placebo or @entity2993 and @entity3709 on top oral anticoagulation therapy. Neuropsychological performance and inflammatory markers in the blood were assessed at baseline and 1 year later together with amygdala and hippocampal volume as well as @entity62 . RESULTS: Sixty-three @entity1 were assessed for eligibility, but 29 @entity1 had to be excluded so that 34 @entity1 were randomized to both groups. In the treatment group, the systemic level of inflammation was significantly decreased after 1 year and an improvement in cognitive speed as well as short- and long-term memory was observed. While there was no significant difference in MTL volume at baseline, the placebo group exhibited more @entity194 for right amygdala and left hippocampus at follow-up. Finally, descriptive data showed a slight decline of @entity62 volume in the treatment group. CONCLUSIONS: In spite of limitations due to small sample size, our data suggest that intensive @entity165 lowering therapy in @entity955 @entity1 may slow @entity73 and @entity194 of the MTL. Though these results have to be replicated in a larger sample, they offer potential for future interventions.

title: One-year @entity165 lowering treatment reduces medial temporal lobe XXXX and memory decline in @entity64 -free elderly with @entity955 : evidence from a parallel group randomized trial.

answer: @entity194 :: (MESH:D001284,Disease) :: ['atrophy']


abstract: OBJECTIVES: In elderly @entity1 with @entity955 ( @entity955 ), medial temporal lobe (MTL) @entity194 and @entity62 ( @entity62 ) may account for the @entity73 . Though a combination therapy of statins with @entity165 lowering agents like @entity3709 may be beneficial in @entity1 with @entity955 , its effects on MTL structure and @entity62 remains unknown. METHODS: A parallel group double-blinded randomized trial was performed during 1 year whereby elderly @entity64 -free @entity955 @entity1 either received placebo or @entity2993 and @entity3709 on top oral anticoagulation therapy. Neuropsychological performance and inflammatory markers in the blood were assessed at baseline and 1 year later together with amygdala and hippocampal volume as well as @entity62 . RESULTS: Sixty-three @entity1 were assessed for eligibility, but 29 @entity1 had to be excluded so that 34 @entity1 were randomized to both groups. In the treatment group, the systemic level of inflammation was significantly decreased after 1 year and an improvement in cognitive speed as well as short- and long-term memory was observed. While there was no significant difference in MTL volume at baseline, the placebo group exhibited more @entity194 for right amygdala and left hippocampus at follow-up. Finally, descriptive data showed a slight decline of @entity62 volume in the treatment group. CONCLUSIONS: In spite of limitations due to small sample size, our data suggest that intensive @entity165 lowering therapy in @entity955 @entity1 may slow @entity73 and @entity194 of the MTL. Though these results have to be replicated in a larger sample, they offer potential for future interventions.

title: One-year @entity165 lowering treatment reduces medial temporal lobe @entity194 and memory decline in @entity64 -free elderly with XXXX : evidence from a parallel group randomized trial.

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: OBJECTIVES: In elderly @entity1 with @entity955 ( @entity955 ), medial temporal lobe (MTL) @entity194 and @entity62 ( @entity62 ) may account for the @entity73 . Though a combination therapy of statins with @entity165 lowering agents like @entity3709 may be beneficial in @entity1 with @entity955 , its effects on MTL structure and @entity62 remains unknown. METHODS: A parallel group double-blinded randomized trial was performed during 1 year whereby elderly @entity64 -free @entity955 @entity1 either received placebo or @entity2993 and @entity3709 on top oral anticoagulation therapy. Neuropsychological performance and inflammatory markers in the blood were assessed at baseline and 1 year later together with amygdala and hippocampal volume as well as @entity62 . RESULTS: Sixty-three @entity1 were assessed for eligibility, but 29 @entity1 had to be excluded so that 34 @entity1 were randomized to both groups. In the treatment group, the systemic level of inflammation was significantly decreased after 1 year and an improvement in cognitive speed as well as short- and long-term memory was observed. While there was no significant difference in MTL volume at baseline, the placebo group exhibited more @entity194 for right amygdala and left hippocampus at follow-up. Finally, descriptive data showed a slight decline of @entity62 volume in the treatment group. CONCLUSIONS: In spite of limitations due to small sample size, our data suggest that intensive @entity165 lowering therapy in @entity955 @entity1 may slow @entity73 and @entity194 of the MTL. Though these results have to be replicated in a larger sample, they offer potential for future interventions.

title: One-year XXXX lowering treatment reduces medial temporal lobe @entity194 and memory decline in @entity64 -free elderly with @entity955 : evidence from a parallel group randomized trial.

answer: @entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']


abstract: A surveillance study was conducted to determine the in-hospital and long-term prognostic value of @entity308 assessed by ambulatory electrocardiographic monitoring (AEM) during the early in-hospital period after @entity583 ( @entity583 ). @entity308 ( @entity308 ) was determined by computer analysis of 24-h ECG tapes as a horizontal or downsloping change in ST level by > 0.1 mV from the reference base line. The ST level was measured 80 ms after the J point of all normally conducted complexes for > or = 1 min. All computer-detected ST events were verified by one trained reader. Tapes corresponding to 74 @entity1 were analyzed. In addition, 23 tapes corresponding to age- and gender-matched controls were also analyzed. @entity1 were divided into two groups: 22 @entity1 (30%) showed @entity308 (Group A), and 52 @entity1 (70%) had no episode of @entity308 (Group B). Among controls, 1 @entity1 (4%) showed @entity308 . During the early follow-up period (14 +/- 11 days after hospital admission), @entity299 occurred in 11 @entity1 [7 (32%) in Group A and 4(8%) in Group B, p < 0.01], including 6 @entity204 [5 (23%) in Group A and 1 (2%) in Group B, p < 0.01], 3 acute coronary artery bypass surgeries [2 (9%) in Group A and 1 (2%) in Group B, p = NS], and 2 nonfatal @entity296 (both in Group A, p = NS). During a mean follow-up period of 3 years (36 +/- 15 months), 18 @entity1 died [10 (45%) in Group A and 8 (15%) in Group B, p = 0.01]. Eleven deaths were sudden [7 (32%) in Group A and 4 (8%) in Group B, p < 0.01]. Eighteen @entity583 occurred [11 (50%) in Group A and 7 (13%) in Group B, p < 0.005]. Twenty @entity1 underwent revascularization procedures [7 (32%) in Group A and 13 (25%) in Group B, p = NS].(ABSTRACT TRUNCATED AT 250 WORDS)

title: XXXX on ambulatory electrocardiography in the early in-hospital period after @entity583 predicts early and late mortality: a short-term and a 3-year follow-up study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'person']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['ST-segment depression', 'STD']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial infractions']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']

answer: @entity308 :: (MESH:D003866,Disease) :: ['ST-segment depression']


abstract: A surveillance study was conducted to determine the in-hospital and long-term prognostic value of @entity308 assessed by ambulatory electrocardiographic monitoring (AEM) during the early in-hospital period after @entity583 ( @entity583 ). @entity308 ( @entity308 ) was determined by computer analysis of 24-h ECG tapes as a horizontal or downsloping change in ST level by > 0.1 mV from the reference base line. The ST level was measured 80 ms after the J point of all normally conducted complexes for > or = 1 min. All computer-detected ST events were verified by one trained reader. Tapes corresponding to 74 @entity1 were analyzed. In addition, 23 tapes corresponding to age- and gender-matched controls were also analyzed. @entity1 were divided into two groups: 22 @entity1 (30%) showed @entity308 (Group A), and 52 @entity1 (70%) had no episode of @entity308 (Group B). Among controls, 1 @entity1 (4%) showed @entity308 . During the early follow-up period (14 +/- 11 days after hospital admission), @entity299 occurred in 11 @entity1 [7 (32%) in Group A and 4(8%) in Group B, p < 0.01], including 6 @entity204 [5 (23%) in Group A and 1 (2%) in Group B, p < 0.01], 3 acute coronary artery bypass surgeries [2 (9%) in Group A and 1 (2%) in Group B, p = NS], and 2 nonfatal @entity296 (both in Group A, p = NS). During a mean follow-up period of 3 years (36 +/- 15 months), 18 @entity1 died [10 (45%) in Group A and 8 (15%) in Group B, p = 0.01]. Eleven deaths were sudden [7 (32%) in Group A and 4 (8%) in Group B, p < 0.01]. Eighteen @entity583 occurred [11 (50%) in Group A and 7 (13%) in Group B, p < 0.005]. Twenty @entity1 underwent revascularization procedures [7 (32%) in Group A and 13 (25%) in Group B, p = NS].(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity308 on ambulatory electrocardiography in the early in-hospital period after XXXX predicts early and late mortality: a short-term and a 3-year follow-up study.

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']


abstract: OBJECTIVE: To study the effect of @entity8671 on vascular biomarkers and carotid @entity121 ( @entity121 ) in @entity1252 ( @entity1252 ). METHODS: @entity1252 @entity1 with inactive disease and subclinical @entity731 were randomized in a double-blinded manner to receive either @entity8671 (10 mg/day) or matching placebo (half in each group were also randomly allocated low-dose @entity117 ). After 12 months, treatment was unblinded. @entity1 treated with @entity8671 and @entity117 were continued on the same medications for another 12 months. Plasma levels of @entity1255 , high-sensitivity C-reactive protein (hsCRP), soluble @entity4725 , @entity8729 , and thrombomodulin were measured at baseline, 6 months, and 12 months. Measurement of carotid @entity121 was repeated at 24 months. RESULTS: Seventy-two @entity1 were studied (97% @entity1 , mean    SD age 50.8    9.7 years). Thirty-six @entity1 were randomly assigned to each of the study arms (18 @entity1 in each arm also received @entity117 ). Baseline clinical characteristics and medications were similar between the two groups. At 12 months, the mean low-density lipoprotein @entity165 (mean    SD 2.62    1.04 mmoles/liter to 1.69    0.72 mmoles/liter; P < 0.001) and median hsCRP levels (1.26 mg/liter, interquartile range [IQR] 2.3 to 0.88 mg/liter, IQR 1.1; P = 0.02) decreased significantly in the @entity8671 group. There was no significant change in @entity1255 , and @entity117 use did not influence the levels of the biomarkers studied. A subgroup analysis of @entity1 with a @entity1252 Activity Index score  <=2 revealed a significant decrease in hsCRP (1.20 mg/liter, IQR 2.3 to 0.92 mg/liter, IQR 1.1; P = 0.04) and thrombomodulin levels (0.76 ng/ml, IQR 1.2 to 0.67 ng/ml, IQR 1.0; P = 0.001) with @entity8671 treatment. At 24 months, the @entity121 of the internal carotid arteries appeared to be decreased in @entity1 treated with @entity8671 , which was well tolerated. CONCLUSION: In stable @entity1252 @entity1 , low-dose @entity8671 leads to a significant reduction in hsCRP and thrombomodulin levels, which may possibly help to reduce cardiovascular risk.

title: Effects of XXXX on vascular biomarkers and carotid atherosclerosis in lupus: a randomized, double-blind, placebo-controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'women']

entities_list: @entity1255 :: ('MESH:D006710', 'Chemical') :: ['homocysteine']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus', 'Systemic Lupus Erythematosus Disease']

entities_list: @entity4725 :: ('7412', 'Gene') :: ['vascular cell adhesion molecule 1']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness']

answer: @entity8671 :: (MESH:C422923,Chemical) :: ['rosuvastatin']


abstract: UNASSIGNED: Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of @entity19 @entity1028 ( @entity1028 ). @entity6970 (-/-) @entity19 were implanted with saline- or @entity15395 ( @entity15395 )-filled miniosmotic pumps then treated with either the autophagy inhibitor @entity503 (CQ; 50 mg  (kg body mass)(-1)  day(-1), by intraperitoneal injection) or saline. @entity15395 -elicited aneurysmal expansion of the suprarenal aorta coupled with @entity715 formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for @entity15395 compared with 46.2% for @entity15395 + CQ; P = NS) and categorical distribution of @entity439 . The markedly reduced survival rate observed with @entity15395 (57.1% for @entity15395 compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for @entity15395 + CQ; P = NS compared with @entity15395 ). CQ did not affect the mean maximum suprarenal aortic diameter (1.91    0.19 mm for @entity15395 compared with 1.97    0.21 mm for @entity15395 + CQ; P = NS). @entity20616 fragmentation, collagen accumulation, and smooth @entity121 , which were higher in @entity15395 -treated @entity19 , were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental @entity1028 , suggesting that global loss of autophagy is unlikely to be a causal factor in the development of @entity449 . Manipulation of autophagy as a mechanism to reduce @entity1028 may need re-evaluation.

title: Effects of long-term XXXX administration on the natural history of @entity449 in @entity19 .

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle attrition']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysms']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity503 :: ('MESH:D002738', 'Chemical') :: ['chloroquine']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysms', 'AAA']

answer: @entity503 :: (MESH:D002738,Chemical) :: ['chloroquine']


abstract: UNASSIGNED: Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of @entity19 @entity1028 ( @entity1028 ). @entity6970 (-/-) @entity19 were implanted with saline- or @entity15395 ( @entity15395 )-filled miniosmotic pumps then treated with either the autophagy inhibitor @entity503 (CQ; 50 mg  (kg body mass)(-1)  day(-1), by intraperitoneal injection) or saline. @entity15395 -elicited aneurysmal expansion of the suprarenal aorta coupled with @entity715 formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for @entity15395 compared with 46.2% for @entity15395 + CQ; P = NS) and categorical distribution of @entity439 . The markedly reduced survival rate observed with @entity15395 (57.1% for @entity15395 compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for @entity15395 + CQ; P = NS compared with @entity15395 ). CQ did not affect the mean maximum suprarenal aortic diameter (1.91    0.19 mm for @entity15395 compared with 1.97    0.21 mm for @entity15395 + CQ; P = NS). @entity20616 fragmentation, collagen accumulation, and smooth @entity121 , which were higher in @entity15395 -treated @entity19 , were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental @entity1028 , suggesting that global loss of autophagy is unlikely to be a causal factor in the development of @entity449 . Manipulation of autophagy as a mechanism to reduce @entity1028 may need re-evaluation.

title: Effects of long-term @entity503 administration on the natural history of XXXX in @entity19 .

answer: @entity449 :: (MESH:D001014,Disease) :: ['aortic aneurysms']


abstract: UNASSIGNED: Autophagy regulates cellular homeostasis and integrates the cellular pro-survival machinery. We investigated the role of autophagy in the natural history of @entity19 @entity1028 ( @entity1028 ). @entity6970 (-/-) @entity19 were implanted with saline- or @entity15395 ( @entity15395 )-filled miniosmotic pumps then treated with either the autophagy inhibitor @entity503 (CQ; 50 mg  (kg body mass)(-1)  day(-1), by intraperitoneal injection) or saline. @entity15395 -elicited aneurysmal expansion of the suprarenal aorta coupled with @entity715 formation were apparent 8 weeks later. CQ had no impact on the incidence (50% for @entity15395 compared with 46.2% for @entity15395 + CQ; P = NS) and categorical distribution of @entity439 . The markedly reduced survival rate observed with @entity15395 (57.1% for @entity15395 compared with 100% for saline; P < 0.05) was unaffected by CQ (61.5% for @entity15395 + CQ; P = NS compared with @entity15395 ). CQ did not affect the mean maximum suprarenal aortic diameter (1.91    0.19 mm for @entity15395 compared with 1.97    0.21 mm for @entity15395 + CQ; P = NS). @entity20616 fragmentation, collagen accumulation, and smooth @entity121 , which were higher in @entity15395 -treated @entity19 , were unaffected by CQ treatment. Long-term CQ administration does not affect the natural history and prognosis of experimental @entity1028 , suggesting that global loss of autophagy is unlikely to be a causal factor in the development of @entity449 . Manipulation of autophagy as a mechanism to reduce @entity1028 may need re-evaluation.

title: Effects of long-term @entity503 administration on the natural history of @entity449 in XXXX .

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: An in vitro model of @entity1566 was developed to study the pathophysiology of posttraumatic @entity409 . A 25 mm length of thoracic spinal cord was removed from the adult male @entity35 (n = 27). A dorsal column segment was isolated and pinned in a recording chamber and superfused with oxygenated (95% O2/5% @entity515 ) Ringer. The cord was stimulated with a bipolar electrode, while two point responses were recorded extracellularly. Injury was accomplished by compression with a modified @entity439 which applied a 2 g force for 15 s. With injury the compound action potential (CAP) amplitude decreased to 53.7 +/- 5.4% (P < 0.001), while the latency increased to 115.6 +/- 3.1% (P < 0.0025) of control values. The absolute refractory period increased with injury from 1.7 +/- 0.1 ms to 2.1 +/- 0.1 ms (P < 0.05). The infusion of 5 mM @entity973 ( @entity974 ), a blocker of voltage-sensitive 'fast' K channels confined to internodal regions, resulted in broadening of the CAP of injured axons to 114.9 +/- 3.1% of control (P < 0.05). Ultrastructural analysis of the injured dorsal column segments revealed marked axonal and myelin pathology, including considerable myelin disruption. In conclusion, we have developed and characterized an in vitro model of @entity1 @entity1566 which simulates many of the features of in vivo @entity130 . Injured axons display characteristic changes in physiological function including a shift in refractory period and high frequency conduction failure. The ultrastructural data and response of injured axons to 4-AP suggest that myelin disruption with exposure of 'fast' K+ channels contributes to posttraumatic @entity409 .

title: XXXX in an in vitro model of acute compressive injury to adult @entity35 spinal cord axons.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity973 :: ('MESH:D015761', 'Chemical') :: ['4-aminopyridine']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['axonal dysfunction']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm clip']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

answer: @entity409 :: (MESH:D008107,Disease) :: ['Assessment of axonal dysfunction']


abstract: An in vitro model of @entity1566 was developed to study the pathophysiology of posttraumatic @entity409 . A 25 mm length of thoracic spinal cord was removed from the adult male @entity35 (n = 27). A dorsal column segment was isolated and pinned in a recording chamber and superfused with oxygenated (95% O2/5% @entity515 ) Ringer. The cord was stimulated with a bipolar electrode, while two point responses were recorded extracellularly. Injury was accomplished by compression with a modified @entity439 which applied a 2 g force for 15 s. With injury the compound action potential (CAP) amplitude decreased to 53.7 +/- 5.4% (P < 0.001), while the latency increased to 115.6 +/- 3.1% (P < 0.0025) of control values. The absolute refractory period increased with injury from 1.7 +/- 0.1 ms to 2.1 +/- 0.1 ms (P < 0.05). The infusion of 5 mM @entity973 ( @entity974 ), a blocker of voltage-sensitive 'fast' K channels confined to internodal regions, resulted in broadening of the CAP of injured axons to 114.9 +/- 3.1% of control (P < 0.05). Ultrastructural analysis of the injured dorsal column segments revealed marked axonal and myelin pathology, including considerable myelin disruption. In conclusion, we have developed and characterized an in vitro model of @entity1 @entity1566 which simulates many of the features of in vivo @entity130 . Injured axons display characteristic changes in physiological function including a shift in refractory period and high frequency conduction failure. The ultrastructural data and response of injured axons to 4-AP suggest that myelin disruption with exposure of 'fast' K+ channels contributes to posttraumatic @entity409 .

title: @entity409 in an in vitro model of acute compressive injury to adult XXXX spinal cord axons.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: @entity1204 are a heterogenous group of @entity5 that show variable histologies, @entity74 and clinical outcomes. The idea of rigid distinctions between @entity5 types is appealing to pathologists, gynecologists, researchers and @entity1 , but in a recent study where high grade @entity1204 were reviewed by three experienced gynecologic pathologists, diagnostic agreement about @entity5 type was reached in only approximately one half of cases. In general, biologically and clinically validated diagnostic criteria are lacking for high grade @entity1204 and for those that appear mixed epithelial. Until such criteria are developed, it remains important to define which morphologic patterns convey accurate clinical and biological information and which do not or might not. " @entity1204 with ambiguous features," the focus of this review, are @entity5 with comparatively uninformative morphologic features. Some publications indicate that gland forming and @entity1204 that appear morphologically low grade or ambiguous are really high grade. There are also indications that high grade @entity1204 are biologically heterogeneous and that the morphologic clues we currently use to distinguish one subtype from another fail to correlate with biological data. Many @entity5 that appear morphologically mixed are, in fact, not biologically or clinically confused: most represent biologically "pure" @entity5 with variant morphology. Interesting associations between the presence of @entity4309 ( @entity14 ) and ambiguous morphology have been discussed in the literature. An apparent relationship between morphologic ambiguity and malignant mixed @entity5 ( @entity3905 ) also exists. The identity of some morphologically ambiguous @entity1204 can be elucidated with immunohistochemistry or other ancillary techniques at present, but the nature of many still remains undefined. This review presents the concept of morphologically ambiguous @entity1204 , proposes morphological gold standard diagnostic criteria for @entity5 that are not ambiguous (an effort that helps define @entity5 that are ambiguous), provides a relevant literature review and offers practical guidance for sorting through diagnostically challenging cases.

title: XXXX with ambiguous features.

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'papillary endometrial carcinomas', 'endometrial carcinomas', 'Endometrial carcinomas']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch Syndrome']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'M  llerian tumor', 'tumors']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['molecular abnormalities']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['hereditary nonpolyposis colorectal carcinoma syndrome']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['Endometrial carcinomas']


abstract: INTRODUCTION: @entity75 ( @entity75 ) has been reported to occur in @entity1 with @entity3036 . In both conditions there is evidence to suggest disordered cerebral autoregulation. OBJECTIVES: We sought to investigate the concurrence of @entity75 with @entity3036 and to describe the associated obstetric, radiologic and critical care correlates. METHODS: Single center 2001-2010 retrospective cohort study of all @entity1 with @entity3036 who underwent neuroimaging via magnetic resonance imaging (MRI) or computerized tomography (CT) with or without contrast. The medical records of all @entity1 with @entity3036 during the study interval were identified, evaluated and extracted for pertinent data; a diagnosis of @entity75 was made by radiologists using standard criteria. RESULTS: Forty-six of forty-seven (97.9%) @entity1 with @entity3036 revealed @entity75 on neuroimaging using one or more modalities: MRI without contrast=41 (87.2%), MRI with contrast=27 (57.4%), CT without contrast=16 (34%), CT with contrast=7 (14.8%) and/or MRA/ @entity5765 (4.3%). @entity75 was identified within the parietal (36, 78.3%), occipital (35, 76.1%), frontal (29, 63%), temporal (13, 28.3%) and basal ganglia/ brainstem/cerebellum (12, 26.1%). @entity3036 occurred antepartum in 23 @entity1 , postpartum in 24 @entity1 with 22 vaginal/25 cesarean deliveries at a mean maternal age of 21.8 years (range 15-39) and a mean gestational age of 33.9 weeks (range 22.4-41.7 weeks). Ethnicity was African-American in 38 @entity1 . @entity10 was the most common presenting symptom (87.2%) followed by @entity1032 (51.1%), @entity227 (34%) and @entity1209 (19.1%). Severe systolic @entity101 was present in 22 (47%) of @entity1 .Use of antihypertensives (87%), @entity2399 (100%), diuretics (66%) and @entity288 (50%) facilitated maternal recovery in all cases with usually a brief hospitalization (mean 3.9 days, range 1-20 days). CONCLUSION: The common finding of @entity75 in @entity1 with @entity3036 suggests that @entity75 may be part of the pathogenesis of @entity3036 . We speculate that therapy targeted at prevention or reversal of @entity75 pathogenesis will prevent or facilitate recovery from @entity3036 .

title: PP137. @entity75 ( @entity75 ) is a constant component of XXXX .

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['altered mental status']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual disturbances']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['PRES', 'Posterior reversible encephalopathy syndrome']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

entities_list: @entity3036 :: ('MESH:D004461', 'Disease') :: ['eclampsia', 'Eclampsia']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea/vomiting']

answer: @entity3036 :: (MESH:D004461,Disease) :: ['eclampsia']