abstract: This study was aimed to investigate the effect of stress induced by high-intensity exercises on the cardiovascular system. In the epidemiological investigation, 200 subjects (test group) engaged in special high-intensity exercises, and 97 who lived and worked in the same environment and conditions as those in the test group, but did not participate in the exercises served as controls. In the second part of the study, 50 @entity19 were randomly divided into control group, exhaustive swimming group, white noise group, exhaustive swimming plus white noise group, and pioglitazone intervention group. The results showed that the plasma concentrations of the @entity296 markers heart fatty acid-binding protein (H-FABP), @entity24759 ( @entity24759 ), b-endorphin (b-EP) and levels of psychological stress were significantly increased in test group as compared with control group; special high-intensity exercises resulted in a significant elevation of the incidence of @entity943 . Animal experiments showed that the plasma levels of corticosterone (CORT) and troponin I (TnI) were raised while the level of SOD was reduced in exhaustive swimming group, white noise group, and exhaustive swimming plus white noise group. The expression levels of PPARy mRNA and protein were decreased in myocardial tissues in these groups as well. HE staining showed no remarkable change in myocardial tissues in all the groups. Treatment with pioglitazone significantly decreased the plasma levels of TnI and CORT, while increased the level of SOD and the expression levels of PPARy mRNA and protein. It was concluded that the high-intensity exercises may induce a heavy physical and psychological stress and predispose the subjects to accumulated @entity1949 ; high-intensity exercises also increases the incidence of @entity943 and @entity296 . PPARy may be involved in the physical and psychological changes induced by high-intensity exercises.

title: Association between cardiac changes and stress, and the effect of peroxisome proliferator-activated receptor-y on stress-induced @entity296 in XXXX .

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: An operation avoiding a permanent ileostomy is described for @entity1 with @entity31 . The colon and upper half of the rectum are excised and the remaining inflamed mucosa is stripped from the rectal stump down to the dentate line of the anal canal. After excision of all diseased tissue, a reservoir is constructed from the terminal 40 cm of the small intestine. An ileoanal @entity254 via the peranal approach is then carried out. Six @entity1 have been treated, five of whom were followed up for 2-21 months (mean 11 months). One @entity1 died 3 weeks after the operation. The other five are currently well, with no disturbance of urinary or sexual function. The average frequency of evacuation is 5 times in 24 h. Three of these evacuate the reservoir spontaneously and one routinely uses a catheter. (One @entity1 still has an ileostomy). Fecal continence is complete in all during the day and night.

title: [Total colectomy, rectomucosectomy, and ileoanal XXXX with the ileum reservoir in treatment of @entity31 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis']

answer: @entity254 :: (MESH:C563598,Disease) :: ['anastomosis']


abstract: An operation avoiding a permanent ileostomy is described for @entity1 with @entity31 . The colon and upper half of the rectum are excised and the remaining inflamed mucosa is stripped from the rectal stump down to the dentate line of the anal canal. After excision of all diseased tissue, a reservoir is constructed from the terminal 40 cm of the small intestine. An ileoanal @entity254 via the peranal approach is then carried out. Six @entity1 have been treated, five of whom were followed up for 2-21 months (mean 11 months). One @entity1 died 3 weeks after the operation. The other five are currently well, with no disturbance of urinary or sexual function. The average frequency of evacuation is 5 times in 24 h. Three of these evacuate the reservoir spontaneously and one routinely uses a catheter. (One @entity1 still has an ileostomy). Fecal continence is complete in all during the day and night.

title: [Total colectomy, rectomucosectomy, and ileoanal @entity254 with the ileum reservoir in treatment of XXXX ].

answer: @entity31 :: (MESH:D003093,Disease) :: ['ulcerative colitis']


abstract: CONTEXT: Obesity is associated with a pro-inflammatory state and relative @entity6126 . @entity172 (E2) is a potential link between these phenomena because it exhibits negative feedback on gonadotropin secretion and also inhibits production of pro-inflammatory cytokines. OBJECTIVE: We sought to examine the effect of @entity172 priming on the @entity43 in @entity28 . DESIGN, SETTING, AND @entity1 : This was an interventional study at an academic center of 11 @entity28 and 10 normal-weight (NW) @entity1 . INTERVENTION: A frequent blood-sampling study and one month of daily urinary collection were performed before and after administration of transdermal @entity53 0.1 mg/d for one entire menstrual cycle. MAIN OUTCOME MEASURES: Serum LH and FSH before and after @entity1176 stimulation, and urinary @entity172 and @entity1420 metabolites were measured. RESULTS: E2 increased LH pulse amplitude and FSH response to @entity1176 (P = .048, and P < .03, respectively) in @entity28 but not NW @entity1 . After E2 priming, ovulatory @entity28 but not NW @entity1 had a 25% increase in luteal @entity1420 (P = .01). Obese @entity1 had significantly higher baseline @entity650 , @entity688 , @entity2533 , and IL-12 compared with NW (all P < .05); these levels were reduced after E2 (-6% for @entity1356 , -21% for @entity687 , -5% for @entity2533 , -5% for IL-12; all P < .05) in @entity28 but not in NW @entity1 . CONCLUSIONS: E2 priming seems to improve @entity43 function and systemic @entity32 in ovulatory, @entity28 @entity1 . Reducing @entity32 at the pituitary level may decrease the burden of @entity28 on fertility.

title: XXXX Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese @entity1 .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogen']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'PARTICIPANTS']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['hypothalamic-pituitary-ovarian axis']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadotropic hypogonadism']

answer: @entity53 :: (MESH:D004958,Chemical) :: ['Estradiol']


abstract: CONTEXT: Obesity is associated with a pro-inflammatory state and relative @entity6126 . @entity172 (E2) is a potential link between these phenomena because it exhibits negative feedback on gonadotropin secretion and also inhibits production of pro-inflammatory cytokines. OBJECTIVE: We sought to examine the effect of @entity172 priming on the @entity43 in @entity28 . DESIGN, SETTING, AND @entity1 : This was an interventional study at an academic center of 11 @entity28 and 10 normal-weight (NW) @entity1 . INTERVENTION: A frequent blood-sampling study and one month of daily urinary collection were performed before and after administration of transdermal @entity53 0.1 mg/d for one entire menstrual cycle. MAIN OUTCOME MEASURES: Serum LH and FSH before and after @entity1176 stimulation, and urinary @entity172 and @entity1420 metabolites were measured. RESULTS: E2 increased LH pulse amplitude and FSH response to @entity1176 (P = .048, and P < .03, respectively) in @entity28 but not NW @entity1 . After E2 priming, ovulatory @entity28 but not NW @entity1 had a 25% increase in luteal @entity1420 (P = .01). Obese @entity1 had significantly higher baseline @entity650 , @entity688 , @entity2533 , and IL-12 compared with NW (all P < .05); these levels were reduced after E2 (-6% for @entity1356 , -21% for @entity687 , -5% for @entity2533 , -5% for IL-12; all P < .05) in @entity28 but not in NW @entity1 . CONCLUSIONS: E2 priming seems to improve @entity43 function and systemic @entity32 in ovulatory, @entity28 @entity1 . Reducing @entity32 at the pituitary level may decrease the burden of @entity28 on fertility.

title: @entity53 Priming Improves Gonadotrope Sensitivity and Pro-Inflammatory Cytokines in Obese XXXX .

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: BACKGROUND: Thresholds for spinal pelvic parameters in @entity85 ( @entity85 ) were previously defined in North American @entity1 and are commonly used to guide surgical planning. However, it is unclear whether these same threshold parameters can be more widely applied in other geographic regions and in other ethnicities. OBJECTIVE: To evaluate the variation in the radiographic disability thresholds between North American and Japanese @entity85 populations and to adjust sagittal modifier thresholds accordingly. METHODS: Retrospective case series of 717 @entity1 with @entity85 who had baseline radiographs and @entity717 Index (ODI) from North America (n = 518) and Japan (n = 199) were studied. @entity1 were compared at baseline for ODI, ODI offset from age- and ethnic-specific values (ODIni), and radiographic parameters. RESULTS: Significant differences in classification were observed: A greater proportion of Japanese @entity1 had marked pelvic @entity85 , whereas a greater proportion of @entity10479 @entity1 had marked @entity85 ; no difference in the pelvic incidence-lumbar @entity1515 mismatch sagittal modifier was observed. Health-related quality-of-life scores also differed, with a greater ODI raw value observed in the @entity10479 @entity1 but similar ODIni scores between cohorts. Stratifying ODIni scores by sagittal modifier grades revealed similar disability scores corresponding to the 0 to + thresholds for pelvic tilt, pelvic incidence-lumbar @entity1515 mismatch, and sagittal vertical axis across ethnicities. Finally, linear regression analysis demonstrated that compared with @entity10479 @entity1 , Japanese @entity1 had a lower estimated ODI corresponding to established thresholds of @entity85 . CONCLUSION: Our findings demonstrate significant variability in health-related quality-of-life measures and radiographic parameters between North American and Japanese @entity1 , supporting the need for population-adjusted sagittal modifiers to more accurately classify @entity85 . ABBREVIATIONS: @entity85 , adult spinal deformityHRQOL, health-related quality of lifeLL, lumbar lordosisODI, @entity717 IndexODIni, @entity717 Index need for improvementPCS, physical component summaryPI, pelvic incidencePI-LL, pelvic incidence-lumbar @entity1515 mismatchPT, pelvic tiltSRS, Scoliosis Research SocietySVA, sagittal vertical axisTK, @entity1513 .

title: Geographic and Ethnic Variations in Radiographic Disability Thresholds: Analysis of North American and Japanese Operative Adult XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1513 :: ('MESH:D007738', 'Disease') :: ['thoracic kyphosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['SVA deformity', 'deformity', 'radiographic deformity', 'adult spinal deformity', 'tilt deformity', 'ASD']

answer: @entity85 :: (MESH:D009140,Disease) :: ['Spinal Deformity Populations']


abstract: UNASSIGNED: An adequate pancreatic structure is necessary for optimal organ function. Structural changes are critical in the development of age-related @entity660 . In this context, it has been reported that different pancreatic compartments from @entity35 were affected according to the fat composition consumed. Since there is a close relationship between mitochondria, oxidative stress and aging, an experimental approach has been developed to gain more insight into this process in the pancreas. A low dosage of @entity12931 was administered life-long in @entity35 in order to try to prevent pancreatic aging-related alterations associated to some dietary fat sources. According to that, three groups of @entity35 were fed normocaloric diets containing @entity12931 ( @entity5928 ) for two years, where virgin olive, sunflower, or fish oil was included as unique fat source. Pancreatic samples for microscopy and blood samples were collected at the moment of euthanasia. The main finding is that @entity5928 supplementation gives different results according to fat used in diet. When sunflower oil was the main fat in the diet, @entity5928 supplementation seems to improve endocrine pancreas structure and in particular b-cell mass resembling positive effects of virgin olive oil. Conversely, @entity5928 intake does not seem to improve the structural alterations of exocrine compartment previously observed in fish oil fed @entity35 . Therefore @entity5928 may improve pancreatic alterations associated to the chronic intake of some dietary fat sources.

title: Sunflower Oil but Not Fish Oil Resembles Positive Effects of Virgin Olive Oil on Aged Pancreas after Life-Long XXXX Addition.

entities_list: @entity660 :: ('MESH:D010182', 'Disease') :: ['pancreatic disorders']

entities_list: @entity12931 :: ('MESH:D014451', 'Chemical') :: ['Coenzyme Q', 'coenzyme Q']

answer: @entity12931 :: (MESH:D014451,Chemical) :: ['Coenzyme Q']


abstract: PURPOSE: To externally validate the Christodouleas risk model incorporating pathological @entity5 stage, @entity1600 ( @entity1600 ) count and soft tissue surgical margin (STSM) and stratifying @entity1 who develop locoregional recurrence (LR) after radical cystectomy (RC) for @entity150 ( @entity150 ). In addition, we aimed to generate a new model including established clinicopathological features that were absent in the Christodouleas risk model. METHODS: Prospectively assessed multicenter data from 565 @entity1 undergoing RC for @entity150 in 2011 qualified for final analysis. For the purpose of external validation, risk group stratification according to Christodouleas was performed. Competing-risk models were calculated to compare the cumulative incidences of LR after RC. RESULTS: After a median follow-up of 25  months (interquartile range 19-29), the LR-rate was 11.5  %. The Christodouleas model showed a predictive accuracy of 83.2  % in our cohort. In multivariable competing-risk analysis, @entity5 stage >= @entity1803 (HR 4.32, p  <  0.001), positive STSM (HR 2.93, p  =  0.005), @entity3 (HR 3.41, p  <  0.001), the number of removed LNs <10 (HR 2.62, p  <  0.001) and the administration of adjuvant chemotherapy (HR 0.40, p  =  0.008) independently predicted the LR-rate. The resulting risk groups revealed significant differences in LR-rates after 24  months with 4.8  % for low-risk @entity1 , 14.7  % for intermediate-risk @entity1 and 38.9  % for high-risk @entity1 (p  <  0.001 for all), with a predictive accuracy of 85.6  %, respectively. CONCLUSIONS: The Christodouleas risk model has been successfully externally validated in the present prospective series. However, this analysis finds that overall model performance may be improved by incorporating @entity3 . After external validation of the newly proposed risk model, it may be used to identify @entity1 who benefit from an adjuvant therapy and suit for inclusion in clinical trials.

title: Risk stratification for locoregional recurrence after radical cystectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['UCB', 'urothelial carcinoma of the bladder']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['lymphovascular invasion']

answer: @entity150 :: (MESH:D001749,Disease) :: ['urothelial carcinoma of the bladder']


abstract: UNASSIGNED: Transforming growth factor (TGF)-b1 is the most abundant growth factor in @entity1 bone. Several polymorphisms have been described in the @entity2533 gene. To explore the correlation between @entity2533 gene single nucleotide polymorphism and the clinicopathological characteristics of @entity421 . TaqMAN PCR technique was used to detect the @entity2533 gene polymorphism of 124 @entity1 with @entity421 from last follow-up and 136 healthy controls. The difference of gender, age, and allele frequency between @entity1 group and control group with    (2) text were tested. The relationship between single nucleotide polymorphism and the risk of @entity421 with logistic regression and different survival rates of different genotypic @entity1 with @entity421 through Kaplan-Meier were analyzed. There is no remarkable difference of the three genotypes in @entity2533 gene @entity17822 locus between the @entity1 group and control group (P   =   0.26). However, there are significant distributive differences in @entity57109 genotype (P   =   0.04), which shows that @entity1 carrying TT genotype have more risk to get @entity421 than @entity1 carrying CC genotype (odds ratio (OR)   =   2.10, 95  % confidence interval (CI)   =   1.08-4.05). The percentage of T allele frequency of @entity1 group, as 60.1  %, is larger than the control group, as 48.9  %. By comparing with @entity1 carrying CC genotype, @entity1 carrying TT genotype have two times risk of @entity3 (OR   =   2.30, 95  % CI   =   1.05-5.06), and most of them are in the period of Enneking IIB (OR   =   2.54, 95  % CI   =   1.18-5.51). The survival analysis indicates that there is no any significant decrease when there is recurrence in @entity1 carrying TT genotype. The morbidity and @entity3 of @entity421 are relevant to @entity2533 gene @entity57109 single nucleotide polymorphism.

title: Correlation between @entity2533 gene @entity57109 single nucleotide polymorphism and clinicopathological characteristics of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']


abstract: UNASSIGNED: Transforming growth factor (TGF)-b1 is the most abundant growth factor in @entity1 bone. Several polymorphisms have been described in the @entity2533 gene. To explore the correlation between @entity2533 gene single nucleotide polymorphism and the clinicopathological characteristics of @entity421 . TaqMAN PCR technique was used to detect the @entity2533 gene polymorphism of 124 @entity1 with @entity421 from last follow-up and 136 healthy controls. The difference of gender, age, and allele frequency between @entity1 group and control group with    (2) text were tested. The relationship between single nucleotide polymorphism and the risk of @entity421 with logistic regression and different survival rates of different genotypic @entity1 with @entity421 through Kaplan-Meier were analyzed. There is no remarkable difference of the three genotypes in @entity2533 gene @entity17822 locus between the @entity1 group and control group (P   =   0.26). However, there are significant distributive differences in @entity57109 genotype (P   =   0.04), which shows that @entity1 carrying TT genotype have more risk to get @entity421 than @entity1 carrying CC genotype (odds ratio (OR)   =   2.10, 95  % confidence interval (CI)   =   1.08-4.05). The percentage of T allele frequency of @entity1 group, as 60.1  %, is larger than the control group, as 48.9  %. By comparing with @entity1 carrying CC genotype, @entity1 carrying TT genotype have two times risk of @entity3 (OR   =   2.30, 95  % CI   =   1.05-5.06), and most of them are in the period of Enneking IIB (OR   =   2.54, 95  % CI   =   1.18-5.51). The survival analysis indicates that there is no any significant decrease when there is recurrence in @entity1 carrying TT genotype. The morbidity and @entity3 of @entity421 are relevant to @entity2533 gene @entity57109 single nucleotide polymorphism.

title: Correlation between @entity2533 gene XXXX single nucleotide polymorphism and clinicopathological characteristics of @entity421 .

answer: @entity57109 :: (c|SUB|T|29|C,DNAMutation) :: ['29  T   >   C']


abstract: UNASSIGNED: Transforming growth factor (TGF)-b1 is the most abundant growth factor in @entity1 bone. Several polymorphisms have been described in the @entity2533 gene. To explore the correlation between @entity2533 gene single nucleotide polymorphism and the clinicopathological characteristics of @entity421 . TaqMAN PCR technique was used to detect the @entity2533 gene polymorphism of 124 @entity1 with @entity421 from last follow-up and 136 healthy controls. The difference of gender, age, and allele frequency between @entity1 group and control group with    (2) text were tested. The relationship between single nucleotide polymorphism and the risk of @entity421 with logistic regression and different survival rates of different genotypic @entity1 with @entity421 through Kaplan-Meier were analyzed. There is no remarkable difference of the three genotypes in @entity2533 gene @entity17822 locus between the @entity1 group and control group (P   =   0.26). However, there are significant distributive differences in @entity57109 genotype (P   =   0.04), which shows that @entity1 carrying TT genotype have more risk to get @entity421 than @entity1 carrying CC genotype (odds ratio (OR)   =   2.10, 95  % confidence interval (CI)   =   1.08-4.05). The percentage of T allele frequency of @entity1 group, as 60.1  %, is larger than the control group, as 48.9  %. By comparing with @entity1 carrying CC genotype, @entity1 carrying TT genotype have two times risk of @entity3 (OR   =   2.30, 95  % CI   =   1.05-5.06), and most of them are in the period of Enneking IIB (OR   =   2.54, 95  % CI   =   1.18-5.51). The survival analysis indicates that there is no any significant decrease when there is recurrence in @entity1 carrying TT genotype. The morbidity and @entity3 of @entity421 are relevant to @entity2533 gene @entity57109 single nucleotide polymorphism.

title: Correlation between XXXX gene @entity57109 single nucleotide polymorphism and clinicopathological characteristics of @entity421 .

answer: @entity2533 :: (7040,Gene) :: ['TGF-b1']


abstract: Fifty-four @entity1 with @entity6184 due to benign stricture and @entity5 underwent airway reconstruction with a molded Silicone prosthesis (Neville Prosthesis). In 40 @entity1 , the @entity825 was reconstructed with a straight prosthesis; of these 29 had a postintubation stricture and 11 a @entity5 . In the former group, there was one early death from erosion of the innominate artery and five late @entity204 from a variety of causes. The @entity260 were related to @entity738 at the anastomotic site in four @entity1 and were due to the use of non-absorbable suture material. @entity738 occurred in two @entity1 and were successfully treated with fulguration. The lesion was resected and the @entity825 reconstructed with the prosthesis in eight individuals, five of whom are alive, one to six years postoperatively. Of the three @entity1 , in whom the prosthesis served as an intraluminal stent, one who received irradiation is alive three years after operation. In 14 @entity1 , in whom a carinal resection was performed for @entity5 , five individuals are alive, from one to eleven years after surgery. There were four suture line @entity738 in the entire group. All of the @entity204 were attributable to residual or disseminated @entity5 .

title: Reconstruction of the XXXX and stem bronchi with Neville prosthesis.

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas', 'Subglottic granulomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignancy']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity6184 :: ('MESH:D014135', 'Disease') :: ['tracheal stenosis']

answer: @entity825 :: (MESH:D055090,Disease) :: ['trachea']


abstract: BACKGROUND: The benefits of CRT for symptomatic @entity712 ( @entity712 ) @entity1 with a wide QRS and reduced left ventricular ejection fraction (LVEF  <=35%), are well established .Post-hoc subgroup analyses suggest that CRT benefit may extend to @entity1 with LVEF >35%. METHODS: The MIRACLE EF was a prospective, randomized, controlled, double-blinded study to evaluate CRT-P in @entity712 @entity1 with LBBB and with LVEF of 36%-50% and no previous pacing or @entity1479 . The primary endpoint was a composite of time to first @entity712 event or @entity204 . All @entity1 were implanted with a CRT-P and randomized 2:1 to @entity2729 OFF groups. The minimum follow up time was 24months. RESULTS: The MIRACLE EF study was stopped for enrollment futility after 13months and enrolling only 44 @entity1 . The main difficulties in recruiting @entity1 were lack of eligible @entity1 , previous @entity1479 implants, and the reluctance of institutions, @entity1 or physicians to enroll in the study which included a potential 5year CRT OFF period. CONCLUSION: Despite a careful design, identification and randomization of eligible @entity1 were challenging and a trial to assess morbidity and mortality trial was not feasible. The MIRACLE EF experience illustrates the difficulties of designing a scientifically robust but feasible study to assess potential new indications for implantable devices. Smaller randomized studies with surrogate endpoints may therefore be more reasonable, although the potential impact of such studies on clinical practice, guidelines, and reimbursement remain to be determined.

title: Cardiac resynchronization therapy in chronic XXXX with moderately reduced left ventricular ejection fraction: Lessons from the Multicenter InSync Randomized Clinical Evaluation MIRACLE EF study.

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'NYHA II-III HF', 'heart failure']

entities_list: @entity2729 :: ('MESH:C537241', 'Disease') :: ['CRT-P ON or CRT-P']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: UNASSIGNED: Twospotted spider mite, @entity7213 Koch, is an important pest of peppermint in California, USA. Spider mite feeding on peppermint leaves causes physiological changes in the plant, which coupling with the favorable environmental condition can lead to @entity6711 . Significant yield loss can occur in absence of pest monitoring and timely management. Understating the within-field spatial distribution of @entity7213 is critical for the development of reliable sampling plan. The study reported here aims to characterize the spatial distribution of @entity6711 in four commercial peppermint fields in northern California using spatial techniques, variogram and Spatial Analysis by Distance IndicEs (SADIE). Variogram analysis revealed that there was a strong evidence for spatially dependent (aggregated) mite population in 13 of 17 sampling dates and the physical distance of the aggregation reached maximum to 7  m in peppermint fields. Using SADIE, 11 of 17 sampling dates showed aggregated distribution pattern of @entity6711 . Combining results from variogram and SADIE analysis, the @entity1423 of @entity7213 was evident in all four fields for all 17 sampling dates evaluated. Comparing spatial association using SADIE, ca. 62  % of the total sampling pairs showed a positive association of mite spatial distribution patterns between two consecutive sampling dates, which indicates a strong spatial and temporal stability of @entity6711 in peppermint fields. These results are discussed in relation to behavior of spider mite distribution within field, and its implications for improving sampling guidelines that are essential for effective pest monitoring and management.

title: Characterization of spatial distribution of XXXX in peppermint in California and implication for improving sampling plan.

entities_list: @entity7213 :: ('32264', 'Species') :: ['T. urticae', 'Tetranychus urticae']

entities_list: @entity6711 :: ('MESH:D008924', 'Disease') :: ['increased mite infestations', 'mite infestation']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['spatial aggregation']

answer: @entity7213 :: (32264,Species) :: ['Tetranychus urticae']


abstract: AIM: To investigate the treatment strategies and long-term outcomes of radiofrequency ablation (RFA) of @entity157 ( @entity157 ) in difficult locations and to compare the results with non-difficult @entity157 . METHODS: From 2004 to 2012, a total of 470 @entity157 @entity1 underwent ultrasound-guided percutaneous RFA. Among these @entity157 @entity1 , 382 with @entity5 located  <= 5 mm from a major vessel/bile duct (n = 87), from peripheral important structures (n = 232) or from the liver capsule (n = 63) were regarded as difficult cases. There were 331 male @entity1 and 51 female @entity1 , with an average age of 55.3    10.1 years old. A total of 235 and 147 @entity1 had @entity1 -Pugh class A and class B liver function, respectively. The average @entity5 size was 3.4    1.2 cm. Individual treatment strategies were developed to treat these difficult cases. During the same period, 88 @entity157 @entity1 with @entity5 that were not in difficult locations served as the control group. In the control group, 74 @entity1 were male, and 14 @entity1 were female, with an average age of 57.4    11.8 years old. Of these, 62 @entity1 and 26 @entity1 had @entity1 -Pugh class A and class B liver function, respectively. Regular follow-up after RFA was performed to assess treatment efficacy. Survival results were generated from Kaplan-Meier estimates, and multivariate analysis was performed using the Cox regression model. RESULTS: Early @entity5 @entity39 rate in the difficult group was similar to that in the control group (97.6% vs 94.3%, P = 0.080). The complication rate in the difficult group was significantly higher than that in the control group (4.9% vs 0.8%, P = 0.041). The follow-up period ranged from 6 to 116 mo, with an average of 28    22.4 mo. Local progression rate in the difficult group was significantly higher than that in the control group (12.7% vs 7.1%, P = 0.046). However, the 1-, 3-, 5-, and 7-year overall survival rates in the difficult group were not significantly different from those in the control group (84.3%, 54.4%, 41.2%, and 29.9% vs 92.5%, 60.3%, 43.2%, and 32.8%, respectively, P = 0.371). Additionally, a multivariate analysis revealed that @entity5 location was not a significant risk factor for survival. CONCLUSION: There was no significant difference in long-term overall survival between the two groups even though the local progression rate was higher in the difficult group.

title: Radiofrequency ablation of XXXX in difficult locations: Strategies and long-term outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'patients']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: A 34-year-old @entity1 presented at our hospital with @entity1661 due to overeating. Acute @entity6676 was diagnosed. The @entity1 was hospitalized, and nasogastric decompression was initiated. On hospitalization day 3, she developed shock, and her respiratory state deteriorated, requiring intubation and mechanical ventilation. Nasogastric decompression contributed to the improvement in her clinical condition. She was discharged 3 mo after admission. During outpatient follow-up, her dietary intake decreased, and her body weight gradually decreased by 14 kg. An upper gastrointestinal series and endoscopy revealed @entity2203 ; therefore, we performed gastrojejunostomy 18 mo after her initial admission. The @entity1 was discharged from the hospital with no @entity260 . @entity39 and perforation due to overeating-induced @entity6676 are life-threatening conditions. Surgical intervention may be required if delayed @entity2203 occurs after conservative treatment. We report a case of @entity2203 due to overeating-induced @entity6676 treated by gastrojejunostomy 18 mo after the initial presentation.

title: Gastrojejunostomy for @entity2203 after acute XXXX due to overeating.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['Gastric necrosis']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal distention']

entities_list: @entity2203 :: ('MESH:D011707', 'Disease') :: ['pyloric stenosis']

entities_list: @entity6676 :: ('MESH:D013271', 'Disease') :: ['gastric dilatation']

answer: @entity6676 :: (MESH:D013271,Disease) :: ['gastric dilatation']


abstract: A 34-year-old @entity1 presented at our hospital with @entity1661 due to overeating. Acute @entity6676 was diagnosed. The @entity1 was hospitalized, and nasogastric decompression was initiated. On hospitalization day 3, she developed shock, and her respiratory state deteriorated, requiring intubation and mechanical ventilation. Nasogastric decompression contributed to the improvement in her clinical condition. She was discharged 3 mo after admission. During outpatient follow-up, her dietary intake decreased, and her body weight gradually decreased by 14 kg. An upper gastrointestinal series and endoscopy revealed @entity2203 ; therefore, we performed gastrojejunostomy 18 mo after her initial admission. The @entity1 was discharged from the hospital with no @entity260 . @entity39 and perforation due to overeating-induced @entity6676 are life-threatening conditions. Surgical intervention may be required if delayed @entity2203 occurs after conservative treatment. We report a case of @entity2203 due to overeating-induced @entity6676 treated by gastrojejunostomy 18 mo after the initial presentation.

title: Gastrojejunostomy for XXXX after acute @entity6676 due to overeating.

answer: @entity2203 :: (MESH:D011707,Disease) :: ['pyloric stenosis']


abstract: UNASSIGNED: @entity131 ( @entity131 ) is a major cause of @entity204 and disability in all age groups. Among @entity131 , penetrating @entity131 (PTBI) have the worst prognosis and represent the leading cause of @entity131 -related morbidity and @entity204 . However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI @entity35 model: penetrating ballistic-like @entity1545 (PBBI). Early after injury, regional cerebral @entity26 tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, @entity413 uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24   hours after PBBI revealed an incomplete overlap of @entity209 and @entity179 . As expected, the injury core had the most severe @entity209 and @entity179 . However, in the peri-lesional area, despite similar @entity209 , there was lesser @entity179 . Given our findings, the data suggest the presence of two distinct zones of @entity130 , of which only one recovers. We anticipate the peri-lesional area encompassing the @entity2806 , could be salvaged by acute therapies.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 11 February 2015; doi:10.1038/jcbfm.2014.243.

title: XXXX and @entity26 metabolism after penetrating ballistic-like @entity1545 .

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injuries', 'Traumatic brain injury']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['PBBI ischemic penumbra']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic impairment']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'highest neurodegeneration']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['primary injury']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['Glucose']


abstract: UNASSIGNED: @entity131 ( @entity131 ) is a major cause of @entity204 and disability in all age groups. Among @entity131 , penetrating @entity131 (PTBI) have the worst prognosis and represent the leading cause of @entity131 -related morbidity and @entity204 . However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI @entity35 model: penetrating ballistic-like @entity1545 (PBBI). Early after injury, regional cerebral @entity26 tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, @entity413 uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24   hours after PBBI revealed an incomplete overlap of @entity209 and @entity179 . As expected, the injury core had the most severe @entity209 and @entity179 . However, in the peri-lesional area, despite similar @entity209 , there was lesser @entity179 . Given our findings, the data suggest the presence of two distinct zones of @entity130 , of which only one recovers. We anticipate the peri-lesional area encompassing the @entity2806 , could be salvaged by acute therapies.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 11 February 2015; doi:10.1038/jcbfm.2014.243.

title: @entity413 and XXXX metabolism after penetrating ballistic-like @entity1545 .

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: UNASSIGNED: @entity131 ( @entity131 ) is a major cause of @entity204 and disability in all age groups. Among @entity131 , penetrating @entity131 (PTBI) have the worst prognosis and represent the leading cause of @entity131 -related morbidity and @entity204 . However, there are no specific drugs/interventions due to unclear pathophysiology. To gain insights we looked at cerebral metabolism in a PTBI @entity35 model: penetrating ballistic-like @entity1545 (PBBI). Early after injury, regional cerebral @entity26 tension and consumption significantly decreased in the ipsilateral cortex in the PBBI group compared with the control group. At the same time point, @entity413 uptake was significantly reduced globally in the PBBI group compared with the control group. Examination of Fluorojade B-stained brain sections at 24   hours after PBBI revealed an incomplete overlap of @entity209 and @entity179 . As expected, the injury core had the most severe @entity209 and @entity179 . However, in the peri-lesional area, despite similar @entity209 , there was lesser @entity179 . Given our findings, the data suggest the presence of two distinct zones of @entity130 , of which only one recovers. We anticipate the peri-lesional area encompassing the @entity2806 , could be salvaged by acute therapies.Journal of Cerebral Blood Flow _ Metabolism advance online publication, 11 February 2015; doi:10.1038/jcbfm.2014.243.

title: @entity413 and @entity26 metabolism after penetrating ballistic-like XXXX .

answer: @entity1545 :: (MESH:D020214,Disease) :: ['brain injury']


abstract: OBJECTIVES: The aim of the study was to evaluate @entity4783 - @entity1510 effects on the QTc in youth with @entity4784 . @entity4783 is a partial agonist that is an effective treatment for @entity4784 . Compared with @entity284 , it has a lower risk of @entity1162 in adults, but is less studied in the youth. It may also reduce the risk of @entity1166 ( @entity1166 )-an uncommon variant of polymorphic @entity1165 -that can result in @entity1163 , @entity2224 , and @entity944 . METHODS: Secondary analysis of the electrocardiogram data from 95 individuals who participated in a multisite trial for youth with @entity4784 . The @entity1 were randomized to a 2-week (DETOX) or a 12-week course of @entity4783 - @entity1510 (BUP). At baseline, 12-lead electrocardiograms were done at weeks 4 and 12, and QTc intervals were hand-measured and calculated using Bazett formula. Increases above 60 milliseconds were considered clinically significant, and readings above 450 milliseconds (in @entity1 ) and 470 milliseconds (in @entity1 ) indicated a prolonged QTc. RESULTS: Mean QTc intervals were higher for BUP than for DETOX @entity1 at baseline, week 4, and week 12 (P=0.045), and @entity1 had longer mean QTc intervals than @entity1 (P<0.0005). Variations in the QTc intervals were observed in some; however, none were above 500 milliseconds-the level at which risk for @entity1166 becomes more significant. CONCLUSIONS: In this randomized trial, the mean QTc at baseline, before randomization, was higher in BUP than in DETOX @entity1 . Minimal changes in the QTc were seen at 4 and 12 weeks in a few @entity1 in both groups. There was no evidence that @entity4783 - @entity1510 alone increased the QTc to a level that increased the risk for @entity1166 .

title: Presence or Absence of QTc Prolongation in @entity4783 - @entity1510 Among Youth With XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'men']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia']

entities_list: @entity1166 :: ('MESH:D016171', 'Disease') :: ['TdP', 'torsades de pointes']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity4784 :: ('MESH:D009293', 'Disease') :: ['opioid dependence']

entities_list: @entity4783 :: ('MESH:D002047', 'Chemical') :: ['buprenorphine', 'Buprenorphine']

entities_list: @entity1510 :: ('MESH:D009270', 'Chemical') :: ['naloxone']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity284 :: ('MESH:D008691', 'Chemical') :: ['methadone']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['QTc prolongation']

answer: @entity4784 :: (MESH:D009293,Disease) :: ['Opioid Dependence']


abstract: OBJECTIVES: The aim of the study was to evaluate @entity4783 - @entity1510 effects on the QTc in youth with @entity4784 . @entity4783 is a partial agonist that is an effective treatment for @entity4784 . Compared with @entity284 , it has a lower risk of @entity1162 in adults, but is less studied in the youth. It may also reduce the risk of @entity1166 ( @entity1166 )-an uncommon variant of polymorphic @entity1165 -that can result in @entity1163 , @entity2224 , and @entity944 . METHODS: Secondary analysis of the electrocardiogram data from 95 individuals who participated in a multisite trial for youth with @entity4784 . The @entity1 were randomized to a 2-week (DETOX) or a 12-week course of @entity4783 - @entity1510 (BUP). At baseline, 12-lead electrocardiograms were done at weeks 4 and 12, and QTc intervals were hand-measured and calculated using Bazett formula. Increases above 60 milliseconds were considered clinically significant, and readings above 450 milliseconds (in @entity1 ) and 470 milliseconds (in @entity1 ) indicated a prolonged QTc. RESULTS: Mean QTc intervals were higher for BUP than for DETOX @entity1 at baseline, week 4, and week 12 (P=0.045), and @entity1 had longer mean QTc intervals than @entity1 (P<0.0005). Variations in the QTc intervals were observed in some; however, none were above 500 milliseconds-the level at which risk for @entity1166 becomes more significant. CONCLUSIONS: In this randomized trial, the mean QTc at baseline, before randomization, was higher in BUP than in DETOX @entity1 . Minimal changes in the QTc were seen at 4 and 12 weeks in a few @entity1 in both groups. There was no evidence that @entity4783 - @entity1510 alone increased the QTc to a level that increased the risk for @entity1166 .

title: Presence or Absence of QTc Prolongation in @entity4783 - XXXX Among Youth With @entity4784 .

answer: @entity1510 :: (MESH:D009270,Chemical) :: ['Naloxone']


abstract: OBJECTIVES: The aim of the study was to evaluate @entity4783 - @entity1510 effects on the QTc in youth with @entity4784 . @entity4783 is a partial agonist that is an effective treatment for @entity4784 . Compared with @entity284 , it has a lower risk of @entity1162 in adults, but is less studied in the youth. It may also reduce the risk of @entity1166 ( @entity1166 )-an uncommon variant of polymorphic @entity1165 -that can result in @entity1163 , @entity2224 , and @entity944 . METHODS: Secondary analysis of the electrocardiogram data from 95 individuals who participated in a multisite trial for youth with @entity4784 . The @entity1 were randomized to a 2-week (DETOX) or a 12-week course of @entity4783 - @entity1510 (BUP). At baseline, 12-lead electrocardiograms were done at weeks 4 and 12, and QTc intervals were hand-measured and calculated using Bazett formula. Increases above 60 milliseconds were considered clinically significant, and readings above 450 milliseconds (in @entity1 ) and 470 milliseconds (in @entity1 ) indicated a prolonged QTc. RESULTS: Mean QTc intervals were higher for BUP than for DETOX @entity1 at baseline, week 4, and week 12 (P=0.045), and @entity1 had longer mean QTc intervals than @entity1 (P<0.0005). Variations in the QTc intervals were observed in some; however, none were above 500 milliseconds-the level at which risk for @entity1166 becomes more significant. CONCLUSIONS: In this randomized trial, the mean QTc at baseline, before randomization, was higher in BUP than in DETOX @entity1 . Minimal changes in the QTc were seen at 4 and 12 weeks in a few @entity1 in both groups. There was no evidence that @entity4783 - @entity1510 alone increased the QTc to a level that increased the risk for @entity1166 .

title: Presence or Absence of QTc Prolongation in XXXX - @entity1510 Among Youth With @entity4784 .

answer: @entity4783 :: (MESH:D002047,Chemical) :: ['Buprenorphine']


abstract: BACKGROUND: @entity354 ( @entity354 ) is prevalent and related to more severe disease in @entity1 with respiratory problems. We evaluated the effects of antireflux therapy in warfare victims of exposure to @entity5745 with chronic cough. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled, cross-over study was conducted on 45 cases of @entity599 @entity130 with chronic cough (>= 8 weeks) and @entity354 . @entity1 were randomized into two groups, receiving either 20 mg twice daily @entity4546 -placebo (OP) or matching placebo (placebo- @entity4546 [PO]) for 4 months, followed by a 1-month washout period and the alternative treatment for 4 months. Assessments included @entity354 and cough, quality of life, and pulmonary function using spirometry. Leicester Cough Questionnaire and SF-36 were used for measuring quality of life. RESULTS: @entity1 in the OP group experienced a more decrease than those in the PO group in severity of Leicester cough scores during the first 4-month of trial. After crossing the groups, the OP group experienced an increase (P = 0.036) and the PO group experienced a nonsignificant decrease (P = 0.104) in the severity of scores. The OP group also experienced improvement in @entity354 symptoms and quality of life at the end of the trial, but changes in the PO group was not significant. There was no significant change in respiratory function indices in any groups. CONCLUSION: Long-term treatment with high-dose @entity4546 improved @entity354 as well as cough, and quality of life, but not changed respiratory function indices in @entity599 mustard injured cases with respiratory symptoms.

title: Efficacy of @entity4546 on cough, pulmonary function and quality of life of @entity1 with XXXX mustard lung injury: A placebo-control, cross-over clinical trial study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5745 :: ('MESH:D011007', 'Disease') :: ['Mustard gas']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['GERD', 'Gastro-esophageal reflux disease']

entities_list: @entity4546 :: ('MESH:D009853', 'Chemical') :: ['omeprazole']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['mustard injury']

answer: @entity599 :: (MESH:D013455,Chemical) :: ['sulfur']


abstract: BACKGROUND: @entity354 ( @entity354 ) is prevalent and related to more severe disease in @entity1 with respiratory problems. We evaluated the effects of antireflux therapy in warfare victims of exposure to @entity5745 with chronic cough. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled, cross-over study was conducted on 45 cases of @entity599 @entity130 with chronic cough (>= 8 weeks) and @entity354 . @entity1 were randomized into two groups, receiving either 20 mg twice daily @entity4546 -placebo (OP) or matching placebo (placebo- @entity4546 [PO]) for 4 months, followed by a 1-month washout period and the alternative treatment for 4 months. Assessments included @entity354 and cough, quality of life, and pulmonary function using spirometry. Leicester Cough Questionnaire and SF-36 were used for measuring quality of life. RESULTS: @entity1 in the OP group experienced a more decrease than those in the PO group in severity of Leicester cough scores during the first 4-month of trial. After crossing the groups, the OP group experienced an increase (P = 0.036) and the PO group experienced a nonsignificant decrease (P = 0.104) in the severity of scores. The OP group also experienced improvement in @entity354 symptoms and quality of life at the end of the trial, but changes in the PO group was not significant. There was no significant change in respiratory function indices in any groups. CONCLUSION: Long-term treatment with high-dose @entity4546 improved @entity354 as well as cough, and quality of life, but not changed respiratory function indices in @entity599 mustard injured cases with respiratory symptoms.

title: Efficacy of XXXX on cough, pulmonary function and quality of life of @entity1 with @entity599 mustard lung injury: A placebo-control, cross-over clinical trial study.

answer: @entity4546 :: (MESH:D009853,Chemical) :: ['omeprazole']


abstract: BACKGROUND: @entity354 ( @entity354 ) is prevalent and related to more severe disease in @entity1 with respiratory problems. We evaluated the effects of antireflux therapy in warfare victims of exposure to @entity5745 with chronic cough. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled, cross-over study was conducted on 45 cases of @entity599 @entity130 with chronic cough (>= 8 weeks) and @entity354 . @entity1 were randomized into two groups, receiving either 20 mg twice daily @entity4546 -placebo (OP) or matching placebo (placebo- @entity4546 [PO]) for 4 months, followed by a 1-month washout period and the alternative treatment for 4 months. Assessments included @entity354 and cough, quality of life, and pulmonary function using spirometry. Leicester Cough Questionnaire and SF-36 were used for measuring quality of life. RESULTS: @entity1 in the OP group experienced a more decrease than those in the PO group in severity of Leicester cough scores during the first 4-month of trial. After crossing the groups, the OP group experienced an increase (P = 0.036) and the PO group experienced a nonsignificant decrease (P = 0.104) in the severity of scores. The OP group also experienced improvement in @entity354 symptoms and quality of life at the end of the trial, but changes in the PO group was not significant. There was no significant change in respiratory function indices in any groups. CONCLUSION: Long-term treatment with high-dose @entity4546 improved @entity354 as well as cough, and quality of life, but not changed respiratory function indices in @entity599 mustard injured cases with respiratory symptoms.

title: Efficacy of @entity4546 on cough, pulmonary function and quality of life of XXXX with @entity599 mustard lung injury: A placebo-control, cross-over clinical trial study.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: @entity1457 proteins (Hsps) are involved in a variety of critical biological functions, including protein folding, degradation, and translocation and macromolecule assembly, act as molecular chaperones during periods of stress by binding to other proteins. Using expressed sequence tag (EST) and @entity12638 ( @entity12638 ) transcriptome databases, we identified 27 cDNA sequences encoding the conserved J domain, which is found in DnaJ-type Hsps. Of the 27 J domain-containing sequences, 25 were complete cDNA sequences. We divided them into three types according to the number and presence of conserved domains. By analyzing the gene structures, intron numbers, and conserved domains and constructing a phylogenetic tree, we found that the DnaJ family had undergone convergent evolution, obtaining new domains to expand the diversity of its family members. The acquisition of the new DnaJ domains most likely occurred prior to the evolutionary divergence of prokaryotes and eukaryotes. The expression of DnaJ genes in the @entity12638 was generally higher in the fat body. The tissue distribution of @entity71570 proteins was detected by western blotting, demonstrating that in the fifth-instar larvae, the @entity71570 proteins were expressed at their highest levels in hemocytes, followed by the fat body and head. We also found that the @entity71570 transcripts were likely differentially translated in different tissues. Using immunofluorescence cytochemistry, we revealed that in the blood cells, @entity71570 was mainly localized in the cytoplasm.

title: Cloning and analysis of DnaJ family members in the XXXX , @entity12638 .

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['Heat shock']

entities_list: @entity12638 :: ('7091', 'Species') :: ['silkworm', 'Bombyx mori']

answer: @entity12638 :: (7091,Species) :: ['silkworm']


abstract: UNASSIGNED: @entity1457 proteins (Hsps) are involved in a variety of critical biological functions, including protein folding, degradation, and translocation and macromolecule assembly, act as molecular chaperones during periods of stress by binding to other proteins. Using expressed sequence tag (EST) and @entity12638 ( @entity12638 ) transcriptome databases, we identified 27 cDNA sequences encoding the conserved J domain, which is found in DnaJ-type Hsps. Of the 27 J domain-containing sequences, 25 were complete cDNA sequences. We divided them into three types according to the number and presence of conserved domains. By analyzing the gene structures, intron numbers, and conserved domains and constructing a phylogenetic tree, we found that the DnaJ family had undergone convergent evolution, obtaining new domains to expand the diversity of its family members. The acquisition of the new DnaJ domains most likely occurred prior to the evolutionary divergence of prokaryotes and eukaryotes. The expression of DnaJ genes in the @entity12638 was generally higher in the fat body. The tissue distribution of @entity71570 proteins was detected by western blotting, demonstrating that in the fifth-instar larvae, the @entity71570 proteins were expressed at their highest levels in hemocytes, followed by the fat body and head. We also found that the @entity71570 transcripts were likely differentially translated in different tissues. Using immunofluorescence cytochemistry, we revealed that in the blood cells, @entity71570 was mainly localized in the cytoplasm.

title: Cloning and analysis of DnaJ family members in the @entity12638 , XXXX .

answer: @entity12638 :: (7091,Species) :: ['Bombyx mori']


abstract: UNASSIGNED: Cognitive-affective flexibility represents the ability to switch between alternative ways of processing emotional stimuli according to situational demands and individual goals. Although @entity146 has been implicated as a mechanism for the development of @entity148 , there is very limited data on this relationship in @entity1 and adolescents. The aim of the current study was to investigate cognitive-affective flexibility in preadolescents (N  =  112, 50 @entity1 , 11-12 and 13-14  years old) and to examine if this ability is related to individual differences in trait @entity148 . Their interplay was assessed using the modified version of the Flexible Item Selection Task (FIST; Jacques and Zelazo 2001) with non-emotional stimuli (geometrical shapes) and the Emotional FIST (EM-FIST) with emotional stimuli (emotional facial expressions). Performance on the EM-FIST indicated that across the whole age range, trials requiring greater cognitive flexibility were more demanding than nonflexible ones, as revealed by both response time and accuracy performance. Moreover, flexibility demands were higher for younger @entity1 than for older ones but only in terms of response speed. Individual differences in trait @entity148 moderated the impact of flexibility only on the EM-FIST. Being flexible on the EM-FIST was more demanding for high trait anxious @entity1 than for their low trait anxious peers. Lastly, overall @entity1 responded faster than @entity1 , but only in the EM-FIST. These findings extend the presently limited literature concerning variability in cognitive-affective flexibility during this sensitive developmental window.

title: A FISTful of Emotion: Individual Differences in Trait XXXX and Cognitive-Affective Flexibility During Preadolescence.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girls', 'boys']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['reduced flexibility']

answer: @entity148 :: (MESH:D001008,Disease) :: ['Anxiety']


abstract: BACKGROUND: @entity5 is an important malignancy in head and neck area and @entity957 ( @entity957 ) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different @entity5 and their correlation with @entity5 invasiveness has been documented. However, most studies have evaluated @entity1476 and @entity1495 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in @entity1 with laryngeal @entity957 compared to normal subjects and assess any relation with @entity5 clinicopathological findings. MATERIALS AND METHODS: In this case control study, 20 @entity1 with oral @entity957 and 20 healthy subjects were included. Serum levels of @entity1476 and @entity1495 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. RESULTS: @entity1 with laryngeal @entity957 had significantly higher serum levels of @entity1476 (p=0.01) and @entity1495 (p=0.03) compared to healthy subjects. @entity1 with higher T stage (T3,4) had significantly higher @entity1476 (p=0.04) and @entity1495 (p=0.01). There was significant positive correlation between serum levels of @entity1476 with T stage (r=0.45, p=0.04) and lymph node involvement (r=0.563, p=0.01) and between levels of @entity1495 with T stage (r=0.527, p=0.01). CONCLUSIONS: Our results showed that compared to healthy subjects, both @entity1476 and @entity1495 are significantly increased in serum of laryngeal @entity957 cases. @entity1476 was correlated with lymph node involvement while @entity1495 has stronger correlation with T stage compared to @entity1476 .

title: Serum Level of Matrix Metalloproteinase-2 and -9 in @entity1 with XXXX and Clinical Significance.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Laryngeal cancer', 'tumors']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'SCC']

answer: @entity957 :: (MESH:D002294,Disease) :: ['Laryngeal Squamous Cell Carcinoma']


abstract: BACKGROUND: @entity5 is an important malignancy in head and neck area and @entity957 ( @entity957 ) is the most common type accounting for 95% of cases. Increase in matrix metalloproteinases (MMPs) in different @entity5 and their correlation with @entity5 invasiveness has been documented. However, most studies have evaluated @entity1476 and @entity1495 expression and few have evaluated serum levels. The aim of current study was to evaluate serum levels in @entity1 with laryngeal @entity957 compared to normal subjects and assess any relation with @entity5 clinicopathological findings. MATERIALS AND METHODS: In this case control study, 20 @entity1 with oral @entity957 and 20 healthy subjects were included. Serum levels of @entity1476 and @entity1495 were compared between groups and correlations with findings including grade (T) and node involvement (N) were evaluated. RESULTS: @entity1 with laryngeal @entity957 had significantly higher serum levels of @entity1476 (p=0.01) and @entity1495 (p=0.03) compared to healthy subjects. @entity1 with higher T stage (T3,4) had significantly higher @entity1476 (p=0.04) and @entity1495 (p=0.01). There was significant positive correlation between serum levels of @entity1476 with T stage (r=0.45, p=0.04) and lymph node involvement (r=0.563, p=0.01) and between levels of @entity1495 with T stage (r=0.527, p=0.01). CONCLUSIONS: Our results showed that compared to healthy subjects, both @entity1476 and @entity1495 are significantly increased in serum of laryngeal @entity957 cases. @entity1476 was correlated with lymph node involvement while @entity1495 has stronger correlation with T stage compared to @entity1476 .

title: Serum Level of Matrix Metalloproteinase-2 and -9 in XXXX with @entity957 and Clinical Significance.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVE: Rehospitalization affects quality of life and health system efficiency. Although this outcome is a common quality indicator, there are few applications for linking evaluation to risk mitigation at the @entity1 level. This study examined risk factors for rehospitalization to develop an application for supporting care planning based on the interRAI @entity1032 ( @entity1032 ), a commonly available assessment system. METHOD: A retrospective analysis was performed of 53,538 @entity146 inpatients assessed with the interRAI @entity1032 in Ontario, Canada, between January 2010 and May 2014. The interRAI @entity1032 is a clinical system for assessing demographic variables, service utilization, functional status, and clinical needs. @entity2357 models and survival analysis were used to develop the Rehospitalization Clinical Assessment Protocol by predicting 90-day rehospitalization to any inpatient mental health bed. RESULTS: Variables found to significantly predict rehospitalization included 6 or more lifetime hospitalizations (odds ratio [OR] = 1.40), positive symptoms of @entity716 (OR = 1.23), a secondary substance use disorder (OR = 1.13), and being at risk of harm to self (OR = 1.11). Using these variables, the Rehospitalization Clinical Assessment Protocol was derived whereby those at level 2 (highest) were 74% more likely to be rehospitalized within 90 days than those at level 0. By 1-year postdischarge, 30% at level 2 and 18% at level 0 were rehospitalized. CONCLUSIONS: The Rehospitalization Clinical Assessment Protocol is an application supporting care planning for targeting risk of rehospitalization whenever a @entity1 is assessed with the interRAI @entity1032 . Further exploration is needed to understand how the use of this Clinical Assessment Protocol, service processes, and health system structures further mediate or moderate @entity146 rehospitalization risk.

title: Psychiatric Rehospitalization: Development of a XXXX -Level Indicator for Care Planning and Quality Assurance.

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['Mental Health', 'MH']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity2357 :: ('MESH:C537770', 'Disease') :: ['Logistic regression']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

answer: @entity1 :: (9606,Species) :: ['Person']


abstract: The incidence of @entity157 ( @entity157 ) in Europe and throughout the world is currently increasing. This is caused by an increase in the number of @entity1 with @entity409 , @entity209 , and by increasing incidence of @entity1956 and C.From January 1, 2004 to December 31, 2013, resection or radiofrequency ablation of the liver was done in 360 @entity1 with benign lesions or @entity96 . In 28 @entity1 @entity157 was diagnosed and histologically confirmed (7.8 %). Seven @entity1 had @entity157 associated with @entity1575 (25 %), and 21 @entity1 were without histologically confirmed @entity82 (75 %). R0 resection was done in 18 (64 %) @entity1 . @entity532 occurred in 6 (21 %) @entity1 and reoperation due to @entity5 relapse or progression was done eight times in 6 (21 %) @entity1 . One-year and five-year @entity1 ' survivals were 64 % and 10 %, repectively, and did not statistically differ from the survival of the whole set of @entity1 with @entity5 diseases in the given time period.       In the future it will be possible to improve the long-term survival of @entity1 with @entity157 by using screening methods for presymptomatic diagnosis of @entity157 , precise preoperative diagnosis and efforts for R0 resection (Tab. 1, Fig. 4, Ref. 11).

title: Surgical treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['malignant tumors of the liver']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['alcoholic liver damage']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['Surgical complications']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: BACKGROUND: Caregiver burden is a significant issue in the treatment of @entity303 and a known contributor to institutionalization of @entity1 with @entity303 . Published data have documented increased caregiver burden in @entity146 ( @entity146 ) compared to @entity195 ( @entity195 ). Another atypical @entity303 with high-perceived caregiver burden is @entity13895 ( @entity13895 ), but no formal studies have assessed this perception. The aim of this study was to compare caregiver burden across atypical @entity303 etiologies. METHODS: 76 adults with atypical @entity303 (young-onset @entity195 [YOAD], @entity146 , language variant @entity4943 [lvFTD], and @entity13895 ) were administered an abbreviated version of the Zarit Burden Interview (ZBI), @entity146 Inventory (NPI-Q), and other assessment instruments during a five-year time period at Johns Hopkins Hospital (JHH). A Cox regression model examined differences between disease categories that impact mean ZBI scores. RESULTS: Mean ZBI scores were significantly different between @entity303 etiologies, with @entity146 and @entity13895 having the highest caregiver burden (p = 0.026). Mean NPI-Q caregiver distress scores were highest in @entity146 and @entity13895 (p = 0.002), with @entity13895 and @entity146 also having the highest number of endorsed symptom domains (p = 0.012). On regression analyses, an interactive variable combining final diagnosis category and NPI-Q total severity score demonstrated statistically significant differences in mean ZBI scores for @entity13895 and @entity146 . CONCLUSIONS: This study demonstrates that @entity146 and @entity13895 have increased levels of caregiver burden, NPI-Q caregiver distress, total severity scores, and number of endorsed symptom domains. These results suggest that higher caregiver burden in @entity146 and @entity13895 are disease specific and possibly related to @entity146 .

title: Caregiver burden in atypical @entity303 : comparing frontotemporal @entity303 , Creutzfeldt-Jakob disease, and XXXX .

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['bvFTD', 'neuropsychiatric symptoms', 'Neuropsychiatric', 'behavioral variant frontotemporal dementia']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity13895 :: ('MESH:C565143', 'Disease') :: ['sporadic Creutzfeldt-Jakob disease', 'sCJD']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']


abstract: BACKGROUND: Caregiver burden is a significant issue in the treatment of @entity303 and a known contributor to institutionalization of @entity1 with @entity303 . Published data have documented increased caregiver burden in @entity146 ( @entity146 ) compared to @entity195 ( @entity195 ). Another atypical @entity303 with high-perceived caregiver burden is @entity13895 ( @entity13895 ), but no formal studies have assessed this perception. The aim of this study was to compare caregiver burden across atypical @entity303 etiologies. METHODS: 76 adults with atypical @entity303 (young-onset @entity195 [YOAD], @entity146 , language variant @entity4943 [lvFTD], and @entity13895 ) were administered an abbreviated version of the Zarit Burden Interview (ZBI), @entity146 Inventory (NPI-Q), and other assessment instruments during a five-year time period at Johns Hopkins Hospital (JHH). A Cox regression model examined differences between disease categories that impact mean ZBI scores. RESULTS: Mean ZBI scores were significantly different between @entity303 etiologies, with @entity146 and @entity13895 having the highest caregiver burden (p = 0.026). Mean NPI-Q caregiver distress scores were highest in @entity146 and @entity13895 (p = 0.002), with @entity13895 and @entity146 also having the highest number of endorsed symptom domains (p = 0.012). On regression analyses, an interactive variable combining final diagnosis category and NPI-Q total severity score demonstrated statistically significant differences in mean ZBI scores for @entity13895 and @entity146 . CONCLUSIONS: This study demonstrates that @entity146 and @entity13895 have increased levels of caregiver burden, NPI-Q caregiver distress, total severity scores, and number of endorsed symptom domains. These results suggest that higher caregiver burden in @entity146 and @entity13895 are disease specific and possibly related to @entity146 .

title: Caregiver burden in atypical XXXX : comparing frontotemporal @entity303 , Creutzfeldt-Jakob disease, and @entity195 .

answer: @entity303 :: (MESH:D003704,Disease) :: ['dementias']


abstract: BACKGROUND: Caregiver burden is a significant issue in the treatment of @entity303 and a known contributor to institutionalization of @entity1 with @entity303 . Published data have documented increased caregiver burden in @entity146 ( @entity146 ) compared to @entity195 ( @entity195 ). Another atypical @entity303 with high-perceived caregiver burden is @entity13895 ( @entity13895 ), but no formal studies have assessed this perception. The aim of this study was to compare caregiver burden across atypical @entity303 etiologies. METHODS: 76 adults with atypical @entity303 (young-onset @entity195 [YOAD], @entity146 , language variant @entity4943 [lvFTD], and @entity13895 ) were administered an abbreviated version of the Zarit Burden Interview (ZBI), @entity146 Inventory (NPI-Q), and other assessment instruments during a five-year time period at Johns Hopkins Hospital (JHH). A Cox regression model examined differences between disease categories that impact mean ZBI scores. RESULTS: Mean ZBI scores were significantly different between @entity303 etiologies, with @entity146 and @entity13895 having the highest caregiver burden (p = 0.026). Mean NPI-Q caregiver distress scores were highest in @entity146 and @entity13895 (p = 0.002), with @entity13895 and @entity146 also having the highest number of endorsed symptom domains (p = 0.012). On regression analyses, an interactive variable combining final diagnosis category and NPI-Q total severity score demonstrated statistically significant differences in mean ZBI scores for @entity13895 and @entity146 . CONCLUSIONS: This study demonstrates that @entity146 and @entity13895 have increased levels of caregiver burden, NPI-Q caregiver distress, total severity scores, and number of endorsed symptom domains. These results suggest that higher caregiver burden in @entity146 and @entity13895 are disease specific and possibly related to @entity146 .

title: Caregiver burden in atypical @entity303 : comparing frontotemporal XXXX , Creutzfeldt-Jakob disease, and @entity195 .

answer: @entity303 :: (MESH:D003704,Disease) :: ['dementia']


abstract: AIMS: To assess temporal changes in foot ulceration and its risk factors in community-based @entity1 with type 2 @entity6 . METHODS: Baseline data from the longitudinal observational Fremantle @entity6 Study collected from 1993 to 1996 (Phase I) and 2008 to 2011 (Phase II) were analyzed. Generalized linear modeling was used to examine changes in foot @entity1066 prevalence and its associates between phases. Multiple logistic regression was used to determine associates of prevalent foot ulceration in individual and pooled phases. RESULTS: There were 16 foot @entity1066 among 1296 @entity1 in Phase I (1.2%) and 23 in 1509 Phase II @entity1 (1.5%; P=0.86 after age, sex and race/ethnicity adjustment). Glycemic and non-glycemic cardiovascular risk factors were better in Phase II, but @entity6 duration was longer, @entity1897 ( @entity1897 ) was more prevalent and more @entity1 were Aboriginal (P<0.001) than in Phase I. In multivariable analysis of both phases and pooled data, @entity6 duration and @entity1897 ( @entity1897 ) were independent associates of foot ulceration (P <=0.026). Prior hospitalization for @entity1066 , @entity613 , any absent pedal pulse and Aboriginality were also significant in the pooled model (P <=0.009). CONCLUSIONS: Strong associations between foot @entity1066 and @entity6 duration, @entity1897 , symptomatic and clinically-detectable @entity1095 were observed. Aboriginality also proved an independent risk factor. Since all these risk factors apart from @entity613 and impalpable foot pulses were more prevalent in Phase II, improved community- and hospital-based foot care between phases are likely to have attenuated the risk of foot @entity1066 in Phase II @entity1 .

title: Temporal changes in the prevalence and associates of foot ulceration in type 2 XXXX : The Fremantle @entity6 Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral sensory neuropathy', 'PSN']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['intermittent claudication']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: AIMS: To assess temporal changes in foot ulceration and its risk factors in community-based @entity1 with type 2 @entity6 . METHODS: Baseline data from the longitudinal observational Fremantle @entity6 Study collected from 1993 to 1996 (Phase I) and 2008 to 2011 (Phase II) were analyzed. Generalized linear modeling was used to examine changes in foot @entity1066 prevalence and its associates between phases. Multiple logistic regression was used to determine associates of prevalent foot ulceration in individual and pooled phases. RESULTS: There were 16 foot @entity1066 among 1296 @entity1 in Phase I (1.2%) and 23 in 1509 Phase II @entity1 (1.5%; P=0.86 after age, sex and race/ethnicity adjustment). Glycemic and non-glycemic cardiovascular risk factors were better in Phase II, but @entity6 duration was longer, @entity1897 ( @entity1897 ) was more prevalent and more @entity1 were Aboriginal (P<0.001) than in Phase I. In multivariable analysis of both phases and pooled data, @entity6 duration and @entity1897 ( @entity1897 ) were independent associates of foot ulceration (P <=0.026). Prior hospitalization for @entity1066 , @entity613 , any absent pedal pulse and Aboriginality were also significant in the pooled model (P <=0.009). CONCLUSIONS: Strong associations between foot @entity1066 and @entity6 duration, @entity1897 , symptomatic and clinically-detectable @entity1095 were observed. Aboriginality also proved an independent risk factor. Since all these risk factors apart from @entity613 and impalpable foot pulses were more prevalent in Phase II, improved community- and hospital-based foot care between phases are likely to have attenuated the risk of foot @entity1066 in Phase II @entity1 .

title: Temporal changes in the prevalence and associates of foot ulceration in type 2 @entity6 : The Fremantle XXXX Study.

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: @entity6 ( @entity3918 ) is prevalent in @entity82 and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant @entity3918 on microbiota. Cirrhotic outpatients with/without @entity3918 underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without @entity3918 , and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% @entity99 ( @entity99 ), 31% @entity3918 ] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and @entity99 without difference in @entity3918 . Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p<   =   1.0e-02). Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and higher Enterococcaceae and Enterobacteriaceae were seen in hospitalized @entity1 . Concomitant @entity3918 impacted microbiota UNIFRAC (stool, p   =   0.003, mucosa,p   =   0.04) with higher stool Bacteroidaceae and lower Ruminococcaeae. Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations independent of clinical predictors (MELD, @entity99 , PPI). Stool and @entity1049 are altered in cirrhotics who get hospitalized with independent prediction using stool Bacteroidaceae and Clostridiales XIV. Concomitant @entity3918 distinctly impacts gut microbiota without affecting hospitalizations.

title: Gut Microbiota Alterations can predict Hospitalizations in XXXX Independent of @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic encephalopathy', 'HE']

entities_list: @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic mucosal microbiome']

answer: @entity82 :: (MESH:D005355,Disease) :: ['Cirrhosis']


abstract: @entity6 ( @entity3918 ) is prevalent in @entity82 and may modulate the risk of hospitalization through gut dysbiosis. We aimed to define the role of gut microbiota on 90-day hospitalizations and of concomitant @entity3918 on microbiota. Cirrhotic outpatients with/without @entity3918 underwent stool and sigmoid mucosal microbial analysis and were followed for 90 days. Microbial composition was compared between those with/without @entity3918 , and those who were hospitalized/not. Regression/ROC analyses for hospitalizations were performed using clinical and microbial features. 278 cirrhotics [39% @entity99 ( @entity99 ), 31% @entity3918 ] underwent stool while 72 underwent mucosal analyses. Ultimately, 94 were hospitalized and they had higher MELD, proton pump inhibitor (PPI) use and @entity99 without difference in @entity3918 . Stool/mucosal microbiota were significantly altered in those who were hospitalized (UNIFRAC p<   =   1.0e-02). Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and higher Enterococcaceae and Enterobacteriaceae were seen in hospitalized @entity1 . Concomitant @entity3918 impacted microbiota UNIFRAC (stool, p   =   0.003, mucosa,p   =   0.04) with higher stool Bacteroidaceae and lower Ruminococcaeae. Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations independent of clinical predictors (MELD, @entity99 , PPI). Stool and @entity1049 are altered in cirrhotics who get hospitalized with independent prediction using stool Bacteroidaceae and Clostridiales XIV. Concomitant @entity3918 distinctly impacts gut microbiota without affecting hospitalizations.

title: Gut Microbiota Alterations can predict Hospitalizations in @entity82 Independent of XXXX .

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes Mellitus']


abstract: @entity174 of the humeral condyle is exceptional in adults. The purpose was to analyze the results of surgical treatment by open reduction and internal fixation without ligamentous repair. There were six @entity1 with an average age of 31 years. According to the AO classification, five @entity174 were classified as AO type B1 and one as B2. Dislocation was reduced in emergency before osteosynthesis. Postoperatively, the joint was held immobile with a brace for 25.40 days. Five @entity1 were reviewed after a mean follow-up of 52.96 months. The median arc of flexion/extension was 104.80   and 157.8   for pronation-supination. All elbows were stable and all @entity174 were consolidated. Two elbows were @entity158 . The results were satisfactory in five @entity1 . The elbow stability can be ensured only by the synthesis of bone structures. Surgical treatment should restore exact anatomy between the condyle and trochlea. This protocol may provide a joint stability and satisfactory results.

title: XXXX of the humeral condyles in adults   : results of surgical treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'Fracture-dislocation']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Fracture-dislocation']


abstract: BACKGROUND: Endothelin-receptor-antagonist, @entity12584 , has been found to improve the functional capacity and cardiopulmonary hemodynamics in @entity120 ( @entity120 ). Clinical trials have shown the preferable dosage of 125 mg, twice daily, regarding both efficacy and safety. OBJECTIVES: The purpose of this study was to investigate the effects of lower doses of @entity12584 (62.5 mg, twice daily) in combination with @entity7855 on exercise capacity and clinical events, in 41 @entity1 with @entity8577 or @entity120 ( @entity120 ). @entity1 AND METHODS: We assigned 41 @entity1 with @entity120 (non-reactive idiopathic or non-operable chronic @entity1031 ) to receive 62.5 mg of @entity12584 twice daily as combination therapy and evaluated the New York heart association (NYHA) functional class, 6-minutes-walk-distance (6MWD), time to clinical worsening, echocardiographic indexes and clinical events, for an average of 18.5    9.5 months. RESULTS: No adverse drug reaction was observed during the follow-up. Clinical worsening occurred in six (14%) @entity1 , at least one year after treatment, two of the cases failed to respond to 125 mg, twice daily and died. Eight (19%) remained in FC I_II, but didn't reach the goal of 380 meters for 6MWD. All other @entity1 reached the treatment goals according to the latest European society of cardiology (ESC) guidelines. CONCLUSIONS: We observed acceptable results regarding both efficacy and safety with 62.5 mg of @entity12584 , twice daily in this group of @entity1 . Further clinical trials investigating @entity120 with lower dosages of @entity12584 may be warranted.

title: Lower Doses of @entity12584 in Combination With @entity7855 Might be XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['PAH', 'chronic thromboembolic pulmonary hypertension', 'CTEPH', 'Pulmonary Arterial Hypertension']

entities_list: @entity8577 :: ('MESH:D065627', 'Disease') :: ['idiopathic pulmonary hypertension']

entities_list: @entity7855 :: ('MESH:C101426', 'Chemical') :: ['sildenafil']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic']

answer: @entity120 :: (MESH:D006976,Disease) :: ['Beneficial in Pulmonary Arterial Hypertension']


abstract: BACKGROUND: Endothelin-receptor-antagonist, @entity12584 , has been found to improve the functional capacity and cardiopulmonary hemodynamics in @entity120 ( @entity120 ). Clinical trials have shown the preferable dosage of 125 mg, twice daily, regarding both efficacy and safety. OBJECTIVES: The purpose of this study was to investigate the effects of lower doses of @entity12584 (62.5 mg, twice daily) in combination with @entity7855 on exercise capacity and clinical events, in 41 @entity1 with @entity8577 or @entity120 ( @entity120 ). @entity1 AND METHODS: We assigned 41 @entity1 with @entity120 (non-reactive idiopathic or non-operable chronic @entity1031 ) to receive 62.5 mg of @entity12584 twice daily as combination therapy and evaluated the New York heart association (NYHA) functional class, 6-minutes-walk-distance (6MWD), time to clinical worsening, echocardiographic indexes and clinical events, for an average of 18.5    9.5 months. RESULTS: No adverse drug reaction was observed during the follow-up. Clinical worsening occurred in six (14%) @entity1 , at least one year after treatment, two of the cases failed to respond to 125 mg, twice daily and died. Eight (19%) remained in FC I_II, but didn't reach the goal of 380 meters for 6MWD. All other @entity1 reached the treatment goals according to the latest European society of cardiology (ESC) guidelines. CONCLUSIONS: We observed acceptable results regarding both efficacy and safety with 62.5 mg of @entity12584 , twice daily in this group of @entity1 . Further clinical trials investigating @entity120 with lower dosages of @entity12584 may be warranted.

title: Lower Doses of @entity12584 in Combination With XXXX Might be @entity120 .

answer: @entity7855 :: (MESH:C101426,Chemical) :: ['Sildenafil']


abstract: BACKGROUND: Endothelin-receptor-antagonist, @entity12584 , has been found to improve the functional capacity and cardiopulmonary hemodynamics in @entity120 ( @entity120 ). Clinical trials have shown the preferable dosage of 125 mg, twice daily, regarding both efficacy and safety. OBJECTIVES: The purpose of this study was to investigate the effects of lower doses of @entity12584 (62.5 mg, twice daily) in combination with @entity7855 on exercise capacity and clinical events, in 41 @entity1 with @entity8577 or @entity120 ( @entity120 ). @entity1 AND METHODS: We assigned 41 @entity1 with @entity120 (non-reactive idiopathic or non-operable chronic @entity1031 ) to receive 62.5 mg of @entity12584 twice daily as combination therapy and evaluated the New York heart association (NYHA) functional class, 6-minutes-walk-distance (6MWD), time to clinical worsening, echocardiographic indexes and clinical events, for an average of 18.5    9.5 months. RESULTS: No adverse drug reaction was observed during the follow-up. Clinical worsening occurred in six (14%) @entity1 , at least one year after treatment, two of the cases failed to respond to 125 mg, twice daily and died. Eight (19%) remained in FC I_II, but didn't reach the goal of 380 meters for 6MWD. All other @entity1 reached the treatment goals according to the latest European society of cardiology (ESC) guidelines. CONCLUSIONS: We observed acceptable results regarding both efficacy and safety with 62.5 mg of @entity12584 , twice daily in this group of @entity1 . Further clinical trials investigating @entity120 with lower dosages of @entity12584 may be warranted.

title: Lower Doses of XXXX in Combination With @entity7855 Might be @entity120 .

answer: @entity12584 :: (MESH:C086232,Chemical) :: ['Bosentan']


abstract: Radiomics is being explored for potential applications in radiation therapy. How various imaging protocols affect quantitative image features is currently a highly active area of research. To assess the variability of image features derived from conventional [three-dimensional (3D)] and respiratory-gated (RG) positron emission tomography (PET)/computed tomography (CT) images of @entity2 @entity1 , image features were computed from 23 @entity2 @entity1 . Both protocols for each @entity1 were acquired during the same imaging session. PET @entity5 volumes were segmented using an adaptive technique which accounted for background. CT @entity5 volumes were delineated with a commercial segmentation tool. Using RG PET images, the @entity5 center of mass motion, length, and rotation were calculated. Fifty-six image features were extracted from all images consisting of shape descriptors, first-order features, and second-order texture features. Overall, 26.6% and 26.2% of total features demonstrated less than 5% difference between 3D and RG protocols for CT and PET, respectively. Between 10 RG phases in PET, 53.4% of features demonstrated percent differences less than 5%. The features with least variability for PET were sphericity, spherical disproportion, entropy (first and second order), sum entropy, information measure of correlation 2, Short Run Emphasis (SRE), Long Run Emphasis (LRE), and @entity5516 ( @entity5516 ); and those for CT were minimum intensity, mean intensity, Root Mean Square (RMS), Short Run Emphasis (SRE), and @entity5516 . Quantitative analysis using a 3D acquisition versus RG acquisition (to reduce the effects of motion) provided notably different image feature values. This study suggests that the variability between 3D and RG features is mainly due to the impact of respiratory motion.

title: Variability of Image Features Computed from Conventional and Respiratory-Gated PET/CT Images of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity5516 :: ('MESH:D020195', 'Disease') :: ['Run Percentage', 'RPC']

answer: @entity2 :: (MESH:D008175,Disease) :: ['Lung Cancer']


abstract: OBJECTIVE: To evaluate the influence of forward-facing @entity1 restraint systems' (FFCRSs) side impact structure, such as side wings, on the head kinematics and response of a restrained, far- or center-seated 3-year-old anthropomorphic test device (ATD) in oblique sled tests. METHODS: Sled tests were conducted utilizing an FFCRS with large side wings and with the side wings removed. The @entity91 were attached via LATCH on 2 different vehicle seat fixtures-a small SUV rear bench seat and minivan rear bucket seat-secured to the sled carriage at 20   from lateral. Four tests were conducted on each vehicle seat fixture, 2 for each FFCRS configuration. A Q3s dummy was positioned in FFCRS according to the @entity91 owner's manual and FMVSS 213 procedures. The tests were conducted using the proposed FMVSS 213 side impact pulse. Three-dimensional motion cameras collected head excursion data. Relevant data collected during testing included the ATD head excursions, head accelerations, LATCH belt loads, and neck loads. RESULTS: Results indicate that side wings have little influence on head excursions and ATD response. The median lateral head excursion was 435  mm with side wings and 443  mm without side wings. The primary differences in head response were observed between the 2 vehicle seat fixtures due to the vehicle seat head restraint design. The bench seat integrated head restraint forced a tether routing path over the head restraint. Due to the lateral crash forces, the tether moved laterally off the head restraint reducing tension and increasing head excursion (477  mm median). In contrast, when the tether was routed through the bucket seat's adjustable head restraint, it maintained a tight attachment and helped control head excursion (393  mm median). CONCLUSION: This testing illustrated relevant side impact crash circumstances where side wings do not provide the desired head containment for a 3-year-old ATD seated far-side or center in FFCRS. The head appears to roll out of the FFCRS even in the presence of side wings, which may expose the occupant to potential head impact injuries. We postulate that in a center or far-side seating configuration, the absence of door structure immediately adjacent to the @entity91 facilitates the rotation and tipping of the FFCRS toward the impact side and the roll-out of the head around the side wing structure. Results suggest that other prevention measures, in the form of alternative side impact structure design, FFCRS vehicle attachment, or shared protection between the FFCRS and the vehicle, may be necessary to protect @entity1 in oblique side impact crashes.

title: The Influence of Enhanced Side Impact Protection on Kinematics and Injury Measures of Far- or Center-Seated XXXX in Forward-Facing @entity1 Restraints.

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'children']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: OBJECTIVE: To evaluate the influence of forward-facing @entity1 restraint systems' (FFCRSs) side impact structure, such as side wings, on the head kinematics and response of a restrained, far- or center-seated 3-year-old anthropomorphic test device (ATD) in oblique sled tests. METHODS: Sled tests were conducted utilizing an FFCRS with large side wings and with the side wings removed. The @entity91 were attached via LATCH on 2 different vehicle seat fixtures-a small SUV rear bench seat and minivan rear bucket seat-secured to the sled carriage at 20   from lateral. Four tests were conducted on each vehicle seat fixture, 2 for each FFCRS configuration. A Q3s dummy was positioned in FFCRS according to the @entity91 owner's manual and FMVSS 213 procedures. The tests were conducted using the proposed FMVSS 213 side impact pulse. Three-dimensional motion cameras collected head excursion data. Relevant data collected during testing included the ATD head excursions, head accelerations, LATCH belt loads, and neck loads. RESULTS: Results indicate that side wings have little influence on head excursions and ATD response. The median lateral head excursion was 435  mm with side wings and 443  mm without side wings. The primary differences in head response were observed between the 2 vehicle seat fixtures due to the vehicle seat head restraint design. The bench seat integrated head restraint forced a tether routing path over the head restraint. Due to the lateral crash forces, the tether moved laterally off the head restraint reducing tension and increasing head excursion (477  mm median). In contrast, when the tether was routed through the bucket seat's adjustable head restraint, it maintained a tight attachment and helped control head excursion (393  mm median). CONCLUSION: This testing illustrated relevant side impact crash circumstances where side wings do not provide the desired head containment for a 3-year-old ATD seated far-side or center in FFCRS. The head appears to roll out of the FFCRS even in the presence of side wings, which may expose the occupant to potential head impact injuries. We postulate that in a center or far-side seating configuration, the absence of door structure immediately adjacent to the @entity91 facilitates the rotation and tipping of the FFCRS toward the impact side and the roll-out of the head around the side wing structure. Results suggest that other prevention measures, in the form of alternative side impact structure design, FFCRS vehicle attachment, or shared protection between the FFCRS and the vehicle, may be necessary to protect @entity1 in oblique side impact crashes.

title: The Influence of Enhanced Side Impact Protection on Kinematics and Injury Measures of Far- or Center-Seated @entity1 in Forward-Facing XXXX Restraints.

answer: @entity1 :: (9606,Species) :: ['Child']