abstract: INTRODUCTION: @entity75 ( @entity75 ) has been reported to occur in @entity1 with @entity3036 . In both conditions there is evidence to suggest disordered cerebral autoregulation. OBJECTIVES: We sought to investigate the concurrence of @entity75 with @entity3036 and to describe the associated obstetric, radiologic and critical care correlates. METHODS: Single center 2001-2010 retrospective cohort study of all @entity1 with @entity3036 who underwent neuroimaging via magnetic resonance imaging (MRI) or computerized tomography (CT) with or without contrast. The medical records of all @entity1 with @entity3036 during the study interval were identified, evaluated and extracted for pertinent data; a diagnosis of @entity75 was made by radiologists using standard criteria. RESULTS: Forty-six of forty-seven (97.9%) @entity1 with @entity3036 revealed @entity75 on neuroimaging using one or more modalities: MRI without contrast=41 (87.2%), MRI with contrast=27 (57.4%), CT without contrast=16 (34%), CT with contrast=7 (14.8%) and/or MRA/ @entity5765 (4.3%). @entity75 was identified within the parietal (36, 78.3%), occipital (35, 76.1%), frontal (29, 63%), temporal (13, 28.3%) and basal ganglia/ brainstem/cerebellum (12, 26.1%). @entity3036 occurred antepartum in 23 @entity1 , postpartum in 24 @entity1 with 22 vaginal/25 cesarean deliveries at a mean maternal age of 21.8 years (range 15-39) and a mean gestational age of 33.9 weeks (range 22.4-41.7 weeks). Ethnicity was African-American in 38 @entity1 . @entity10 was the most common presenting symptom (87.2%) followed by @entity1032 (51.1%), @entity227 (34%) and @entity1209 (19.1%). Severe systolic @entity101 was present in 22 (47%) of @entity1 .Use of antihypertensives (87%), @entity2399 (100%), diuretics (66%) and @entity288 (50%) facilitated maternal recovery in all cases with usually a brief hospitalization (mean 3.9 days, range 1-20 days). CONCLUSION: The common finding of @entity75 in @entity1 with @entity3036 suggests that @entity75 may be part of the pathogenesis of @entity3036 . We speculate that therapy targeted at prevention or reversal of @entity75 pathogenesis will prevent or facilitate recovery from @entity3036 .

title: PP137. XXXX ( @entity75 ) is a constant component of @entity3036 .

answer: @entity75 :: (MESH:D001927,Disease) :: ['Posterior reversible encephalopathy syndrome']


abstract: INTRODUCTION: @entity75 ( @entity75 ) has been reported to occur in @entity1 with @entity3036 . In both conditions there is evidence to suggest disordered cerebral autoregulation. OBJECTIVES: We sought to investigate the concurrence of @entity75 with @entity3036 and to describe the associated obstetric, radiologic and critical care correlates. METHODS: Single center 2001-2010 retrospective cohort study of all @entity1 with @entity3036 who underwent neuroimaging via magnetic resonance imaging (MRI) or computerized tomography (CT) with or without contrast. The medical records of all @entity1 with @entity3036 during the study interval were identified, evaluated and extracted for pertinent data; a diagnosis of @entity75 was made by radiologists using standard criteria. RESULTS: Forty-six of forty-seven (97.9%) @entity1 with @entity3036 revealed @entity75 on neuroimaging using one or more modalities: MRI without contrast=41 (87.2%), MRI with contrast=27 (57.4%), CT without contrast=16 (34%), CT with contrast=7 (14.8%) and/or MRA/ @entity5765 (4.3%). @entity75 was identified within the parietal (36, 78.3%), occipital (35, 76.1%), frontal (29, 63%), temporal (13, 28.3%) and basal ganglia/ brainstem/cerebellum (12, 26.1%). @entity3036 occurred antepartum in 23 @entity1 , postpartum in 24 @entity1 with 22 vaginal/25 cesarean deliveries at a mean maternal age of 21.8 years (range 15-39) and a mean gestational age of 33.9 weeks (range 22.4-41.7 weeks). Ethnicity was African-American in 38 @entity1 . @entity10 was the most common presenting symptom (87.2%) followed by @entity1032 (51.1%), @entity227 (34%) and @entity1209 (19.1%). Severe systolic @entity101 was present in 22 (47%) of @entity1 .Use of antihypertensives (87%), @entity2399 (100%), diuretics (66%) and @entity288 (50%) facilitated maternal recovery in all cases with usually a brief hospitalization (mean 3.9 days, range 1-20 days). CONCLUSION: The common finding of @entity75 in @entity1 with @entity3036 suggests that @entity75 may be part of the pathogenesis of @entity3036 . We speculate that therapy targeted at prevention or reversal of @entity75 pathogenesis will prevent or facilitate recovery from @entity3036 .

title: PP137. @entity75 ( XXXX ) is a constant component of @entity3036 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['altered mental status']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual disturbances']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['PRES', 'Posterior reversible encephalopathy syndrome']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

entities_list: @entity3036 :: ('MESH:D004461', 'Disease') :: ['eclampsia', 'Eclampsia']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea/vomiting']

answer: @entity75 :: (MESH:D001927,Disease) :: ['PRES']


abstract: INTRODUCTION: @entity1468 is a major cause of maternal and perinatal morbidity and mortality in Brazil and worldwide. It is a heterogeneous and @entity74 , with no clear etiology and pathophysiology. The identification of risk factors for its development may help in prevention and early diagnosis of disease clinical onset. OBJECTIVES: To identify risk factors and complications of @entity1468 ( @entity1468 ) and gestational @entity101 (GH) in a population of primiparas, who had birth care at the Ceilandia Regional Hospital of Brasilia - Federal District. METHODS: Case-control study was conducted from November 2009 to December 2010 in a population of primiparas. We included all primiparas diagnosed with @entity1468 /GH, with random choice of normotensive primiparas in a ratio of 1:3. The variables studied as socio-demographic, @entity532 were collected using pre-tested questionnaire, after informed consent of the pregnant @entity1 . Chi-square and Fisher's multiple comparison were used in the data analysis, considering results significant when p <0.05. RESULTS: Among 1264 primiparas analyzed, 972 (76.9%) were normotensive and 292 (23.1%) @entity101 @entity1 , being 64 (22%) with gestational @entity101 and 228 (78%) with @entity1468 . Risk factors such as maternal age over 35years, @entity1 whose mother and/or sister with chronic @entity101 history or who developed @entity101 during pregnancy, use of male condom as a contraceptive method, @entity28 and excessive @entity1017 during pregnancy showed statistically significant correlation with development of the pathology. CONCLUSION: The development of @entity101 in primiparous @entity1 is associated with family history and @entity28 , factors that can be used as screening for early identification of @entity1 at risk of @entity1468 development.

title: PP175. Gestational XXXX syndromes: Risk factors identification and complications in a primiparous population.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'gestational hypertensive syndrome']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['obstetric, maternal and perinatal complications']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['pre-eclampsia', 'Preeclampsia', 'PE']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['multifactorial disorder']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: PURPOSE: The dysfunctional sympathetic nervous system in individuals with cervical @entity1566 (CSCI) impairs adrenergic responses and may, therefore, contribute to the blunted post-exercise cytokine response. The purpose of this study was to investigate an alternative way to exercise to induce an acute cytokine response by passive core temperature elevation in CSCI. METHODS: Seven male @entity1 with a motor complete CSCI and 8 male able-bodied controls were immersed for 60  min in water set at a temperature 2    C above the individuals' resting oesophageal temperature. Blood was collected pre, post, and every hour up to 4  h post-immersion. RESULTS: Hot water immersion resulted in an @entity650 plasma concentration mean increase of 133      144  % in both groups (P  =  0.001). On a group level, @entity650 plasma concentrations were 68      38  % higher in CSCI (P  =  0.06). In both groups, @entity687 increased by 14      11  % (P  =  0.02) and @entity1193 by 18      17  % (P  =  0.05). @entity5733 plasma concentrations were significantly reduced in CSCI (P  <  0.05) and did not increase following immersion. CONCLUSIONS: Passive elevation of core temperature acutely elevates @entity650 , @entity687 and @entity1193 in CSCI despite a blunted adrenergic response, which is in contrast to earlier exercise interventions in CSCI. The present study lays the foundation for future studies to explore water immersion as an alternative to exercise to induce an acute cytokine response in CSCI.

title: Hot water immersion induces an acute cytokine response in cervical XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity5733 :: ('D002395', 'Chemical') :: ['Catecholamine']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: OBJECTIVE: To study operative mortality and long-term survival following emergency operations for @entity1028 . DESIGN: Retrospective survey in a university hospital. MATERIALS: Two hundred and twenty-seven @entity1 with median age 72 years, (17% @entity1 ). METHODS: Founded on data from the Norwegian Registrar's Office, operative mortality and long-term survival was estimated using the life-table method. Expected survival for demographically matched subgroups was calculated from death rate tables issued by the Norwegian Central Bureau of Statistics. RESULTS: Operative mortality was 41% for the 175 @entity1 with @entity1756 and 17% for the 52 with imminent @entity397 . The 6-year survival rate was 61% for all the successfully operated @entity1 , and not different from that of a demographically matched population. For the @entity1 of 72 years or older the 6-year survival rate was 53%. This was equal to that of an age and sex matched population. The younger @entity1 had an observed 6-year survival rate of 64%, which was significantly lower than the expected of 84%. The standard mortality rate for this group was 2.25. No statistically significant difference in long-term survival was detected between the two age groups. CONCLUSIONS: Age at the time of the operation for a symptomatic @entity1028 does not seem to influence long-term survival. Consequently, younger @entity1 experience a higher relative mortality compared to the older.

title: The influence of age on operative mortality and long-term relative survival following emergency XXXX .

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured aneurysms']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm operations']


abstract: Of 2171 @entity1 who underwent open heart surgery between 1981 and 1986, 41 (1.8%) developed postoperative @entity1764 and were treated by closed irrigation drainage or open chest therapy. Six @entity1 , (mean age 59 years) developed @entity397 of the right ventricular free wall. The primary procedures were: resection of @entity82 (2), mitral valve replacement (1), coronary bypass grafting (1), removal of a left @entity4615 (1) and repair of post- @entity1188 @entity397 of the left ventricle (1). In 2 @entity1 , @entity397 occurred in the operating theatre during revision of the irrigation drainage. Both @entity1 died after repair. In 4 @entity1 , @entity397 occurred during coughing. One died before surgery. In the 3 other cases, the defects were repaired either by direct suture (2 @entity1 ) or with a pericardial patch (1 @entity1 ) with the aid of normothermic extracorporeal circulation. Three days later, a muscular flap (pectoral or dorso-lumbar) was mobilized to protect the mediastinal viscera. All 3 @entity1 are alive and well. When @entity548 occurs during treatment of @entity1764 , an immediate exploration with extracorporeal circulation to close the defect should be considered.

title: Rupture of the right ventricular free wall. An unusual complication of XXXX after cardiac surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['akinetic fibrous plaque']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1764 :: ('MESH:D008480', 'Disease') :: ['mediastinitis']

entities_list: @entity4615 :: ('MESH:C538262', 'Disease') :: ['atrial myxoma']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

answer: @entity1764 :: (MESH:D008480,Disease) :: ['mediastinitis']


abstract: Double outlet right ventricle associated with @entity713 , @entity849 and situs solitus of the atria is a subset of double outlet right ventricle related through the surgical treatment. From 1974 to 1985, 14 @entity1 , 5 males, 9 females (mean age 8.9 years, range 13 months-22 years) were operated upon. All @entity1 had @entity3888 and normal or large pulmonary arteries. The apex of the heart was to the right in 2 @entity1 , the right and left ventricles were superior and inferior in 2 @entity1 and 1 @entity1 had both anomalies. The @entity1757 was subaortic in 11 @entity1 (aorto-mitral discontinuity in 5) and non-committed in 3 @entity1 . Three @entity1 had 2 @entity1757 . The aorta was anterior in 3 @entity1 and to the right of the pulmonary artery in 11 @entity1 . All @entity1 , through a transventricular and transatrial approach, had a reconstructive surgery. In 3 @entity1 , an aortic homograft valved conduit was used. One @entity1 had the @entity1757 enlarged. There was one early @entity204 (7.1%) from high residual right ventricle pressure and no late @entity204 . One @entity1 had a transient @entity713 . One @entity1 was reoperated upon for a residual @entity1757 . All survivors had a good clinical result. Re-evaluation in 8 @entity1 confirmed excellent haemodynamics: the right ventricle to pulmonary artery pressure gradient decreased from 80 mm Hg (range 60-95) preoperatively to 24 mm Hg (range 3-32) postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Exclusive double outlet right ventricle with @entity713 and XXXX . Results of reconstructive surgery.

entities_list: @entity713 :: ('MESH:D054537', 'Disease') :: ['atrioventricular block', 'atrioventricular concordance']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defects', 'ventricular septal defect']

entities_list: @entity3888 :: ('MESH:D011662', 'Disease') :: ['infundibular stenosis']

entities_list: @entity849 :: ('MESH:D011666', 'Disease') :: ['pulmonary stenosis']

answer: @entity849 :: (MESH:D011666,Disease) :: ['pulmonary stenosis']


abstract: Double outlet right ventricle associated with @entity713 , @entity849 and situs solitus of the atria is a subset of double outlet right ventricle related through the surgical treatment. From 1974 to 1985, 14 @entity1 , 5 males, 9 females (mean age 8.9 years, range 13 months-22 years) were operated upon. All @entity1 had @entity3888 and normal or large pulmonary arteries. The apex of the heart was to the right in 2 @entity1 , the right and left ventricles were superior and inferior in 2 @entity1 and 1 @entity1 had both anomalies. The @entity1757 was subaortic in 11 @entity1 (aorto-mitral discontinuity in 5) and non-committed in 3 @entity1 . Three @entity1 had 2 @entity1757 . The aorta was anterior in 3 @entity1 and to the right of the pulmonary artery in 11 @entity1 . All @entity1 , through a transventricular and transatrial approach, had a reconstructive surgery. In 3 @entity1 , an aortic homograft valved conduit was used. One @entity1 had the @entity1757 enlarged. There was one early @entity204 (7.1%) from high residual right ventricle pressure and no late @entity204 . One @entity1 had a transient @entity713 . One @entity1 was reoperated upon for a residual @entity1757 . All survivors had a good clinical result. Re-evaluation in 8 @entity1 confirmed excellent haemodynamics: the right ventricle to pulmonary artery pressure gradient decreased from 80 mm Hg (range 60-95) preoperatively to 24 mm Hg (range 3-32) postoperatively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Exclusive double outlet right ventricle with XXXX and @entity849 . Results of reconstructive surgery.

answer: @entity713 :: (MESH:D054537,Disease) :: ['atrioventricular concordance']


abstract: Recent studies suggest that @entity1 with @entity189 exhibit demographic features that differ from those of @entity1 with @entity957 at other intraoral sites. In this study, we sought to explore this hypothesis in greater detail. Records from the University of Connecticut Oral Biopsy Service from 1975 through 1992 inclusive were surveyed for cases of @entity1697 . A total of 577 cases were retrieved and analyzed with respect to prevalence, gender distribution, and age at diagnosis. We found that the @entity1464 (alveolar ridge included) was the third most common site for oral @entity957 after @entity1697 and tongue. Further, the relative proportion of @entity5 at other intraoral subsites remained essentially constant throughout the study period. Male-to-female ratios were significantly greater for @entity5 as compared with both @entity5 and @entity5 of the @entity1464 (ridge included). Age was not a significant predictor of @entity5 subsite, and there were no apparent differences between @entity189 of the dentate @entity1464 and that of the edentulous ridge. Results of this study indicate that gender-specific predilections exist for @entity957 at different intraoral subsites. These differences suggest the possibility of different etiologic factors and pathogenetic mechanisms involved in @entity189 compared with surface @entity189 at other intraoral sites.

title: XXXX . A case series analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'persons']

entities_list: @entity1697 :: ('MESH:D009062', 'Disease') :: ['carcinoma of the floor of the mouth', 'oral carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer of the tongue', 'cancer', 'gingival cancer versus carcinoma', 'cancer of the floor of the mouth', 'oral cancer']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'squamous carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the gingiva', 'carcinoma']

answer: @entity957 :: (MESH:D002294,Disease) :: ['Squamous cell carcinoma of the gingiva']


abstract: OBJECTIVES: This study aims to evaluate the effect of combining the confidingly preferred modality of radiofrequency (RF) application with intranasal corticosteroid spray treatment on the efficacy of RF and on the number of sessions in @entity1 with @entity1184 of inferior turbinate. @entity1 AND METHODS: Fifty @entity1 (37 males, 13 females; mean age 42.9 years; range 15 to 74 years) who admitted with the complaint of nasal obstruction and were detected to have @entity1184 inferior turbinate by nasal endoscopy were enrolled in the study. The @entity1 were divided into two groups, each consisting of 25 @entity1 . Before the treatment, the severity of nasal obstruction was evaluated and scored by a visual analogue scale (VAS). Radiofrequency was applied to every @entity1 . Control group received no medical treatment following RF application. Drug group received @entity10438 nasal spray (MFNS) at a dose of 200 mcg once daily into both nasal passages for eight weeks following surgery. All @entity1 were asked to return for a control visit at week eight after treatment. Radiofrequency application was repeated in @entity1 who continued to have complaints of nasal blockage. At the end of treatment, @entity1 were reevaluated and VAS scores were recorded. RESULTS: The improvement in VAS scores following treatment was statistically significant in both groups (p<0.05). When the two groups were compared, there was no statistical difference between the two groups before treatment; however there was an improvement in the post-treatment corticostreoid group (p<0.05). The mean session number was calculated to be 1.16 in the control group and 1.08 in the @entity228 treatment group. The difference between the two groups was not statistically significant (p>0.05). CONCLUSION: We recommend the use of intranasal corticosteroids with RF applications to increase the efficacy of radiofrequency.

title: [Evaluation of the effect of intranasal corticosteroid sprays on radiofrequency tissue ablation in the treatment of XXXX inferior turbinate].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy', 'hypertrophied']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity10438 :: ('MESH:C053915', 'Chemical') :: ['mometasone furoate']

answer: @entity1184 :: (MESH:D006984,Disease) :: ['hypertrophied']


abstract: BACKGROUND: @entity10453 is the first long-acting inhaled @entity2263 -agonist available in the US for the maintenance treatment of @entity565 . OBJECTIVE: To compare the safety of @entity10453 with that of the short-acting @entity2263 -agonist @entity3045 . METHODS: Two identically designed, prospective, randomized, double-blind, parallel studies were conducted comparing @entity10453 42 micrograms twice daily, @entity3045 180 micrograms four times daily, and placebo over 12 weeks in 556 @entity1 (12 to 73 years old) with mild-to-moderate @entity102 . @entity1 in each treatment group could use @entity3045 as needed to control acute symptoms. RESULTS: The incidence of potentially drug-related adverse events was similar among the treatment groups (range: 22% to 23%), with @entity10 being the most commonly reported (range: 9% to 10%). No @entity204 occurred during the studies. Concomitant use of > 4 puffs of supplemental @entity3045 per day in the @entity10453 group produced no increase in the incidence of adverse events either in general or of a cardiovascular nature. There were no statistically significant differences among treatment groups or clinically significant changes from pretreatment values in mean pulse rate, @entity551 , or clinical laboratory values after 12 weeks. There were no clinically significant differences among groups in heart rates nor were there differences in the frequency of supraventricular or @entity1540 during 24-hr Holter monitoring. The frequency of @entity565 exacerbations was lowest among @entity1 receiving @entity10453 (and highest among those who received placebo), and this rate did not increase over the 12 weeks. @entity565 exacerbations were treated successfully with nebulized @entity3045 (2.5 mg), with no evidence of any increased risk of cardiovascular events. CONCLUSIONS: @entity10453 42 micrograms twice daily is well-tolerated in @entity1 with @entity565 , having a similar safety profile as that of @entity3045 180 micrograms inhaled four times daily or placebo (plus as-needed @entity3045 ). Concomitant use of @entity3045 , either by @entity13521 or nebulization, did not affect the safety of @entity10453 . Extensive cardiovascular monitoring revealed no significant cardiovascular adverse effects or arrhythmogenic effects associated with @entity10453 over 12 weeks.

title: Safety of XXXX in the maintenance treatment of @entity565 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma', 'Asthma']

entities_list: @entity3045 :: ('MESH:D000420', 'Chemical') :: ['albuterol']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic asthma']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['systolic/diastolic blood pressure']

entities_list: @entity1540 :: ('MESH:D018879', 'Disease') :: ['ventricular ectopic beats']

entities_list: @entity10453 :: ('MESH:C057823', 'Chemical') :: ['salmeterol', 'Salmeterol']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity10453 :: (MESH:C057823,Chemical) :: ['salmeterol']


abstract: BACKGROUND: @entity10453 is the first long-acting inhaled @entity2263 -agonist available in the US for the maintenance treatment of @entity565 . OBJECTIVE: To compare the safety of @entity10453 with that of the short-acting @entity2263 -agonist @entity3045 . METHODS: Two identically designed, prospective, randomized, double-blind, parallel studies were conducted comparing @entity10453 42 micrograms twice daily, @entity3045 180 micrograms four times daily, and placebo over 12 weeks in 556 @entity1 (12 to 73 years old) with mild-to-moderate @entity102 . @entity1 in each treatment group could use @entity3045 as needed to control acute symptoms. RESULTS: The incidence of potentially drug-related adverse events was similar among the treatment groups (range: 22% to 23%), with @entity10 being the most commonly reported (range: 9% to 10%). No @entity204 occurred during the studies. Concomitant use of > 4 puffs of supplemental @entity3045 per day in the @entity10453 group produced no increase in the incidence of adverse events either in general or of a cardiovascular nature. There were no statistically significant differences among treatment groups or clinically significant changes from pretreatment values in mean pulse rate, @entity551 , or clinical laboratory values after 12 weeks. There were no clinically significant differences among groups in heart rates nor were there differences in the frequency of supraventricular or @entity1540 during 24-hr Holter monitoring. The frequency of @entity565 exacerbations was lowest among @entity1 receiving @entity10453 (and highest among those who received placebo), and this rate did not increase over the 12 weeks. @entity565 exacerbations were treated successfully with nebulized @entity3045 (2.5 mg), with no evidence of any increased risk of cardiovascular events. CONCLUSIONS: @entity10453 42 micrograms twice daily is well-tolerated in @entity1 with @entity565 , having a similar safety profile as that of @entity3045 180 micrograms inhaled four times daily or placebo (plus as-needed @entity3045 ). Concomitant use of @entity3045 , either by @entity13521 or nebulization, did not affect the safety of @entity10453 . Extensive cardiovascular monitoring revealed no significant cardiovascular adverse effects or arrhythmogenic effects associated with @entity10453 over 12 weeks.

title: Safety of @entity10453 in the maintenance treatment of XXXX .

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: The supernatant of @entity405 + cells, isolated from a permanent lymphoblastoid cell clone established from a long term culture of a T cell @entity981 , contained two distinct molecules with suppressive activity on @entity35063 -induced PBMC proliferation. This clone does not produce @entity310 , @entity4909 , alpha-IFN, gamma-IFN, @entity1356 , @entity1199 and has not natural killer activity. In the attempt to purify and biochemically characterize the lymphoblastic cell line-derived T-cell SFs, a multi-step chromatographic separation has been used. Two different peaks of biologic activity have been separated by HPLC gel permeation in the range of 100-120 Kd and 75-85 Kd referred to as high molecular weight suppressor factor HMWSF, and low molecular weight suppressor factor LMWSF, respectively. These fractions were then concentrated, dialyzed and further purified by anion exchange HPLC. This chromatographic step allowed us to considerably purify the two SFs. The biologically active fractions derived from the previous chromatographic step were eventually subjected to hydrophobic interaction HPLC (HIC) for final purification. The highly purified material was characterized by @entity2975 gel electrophoresis in @entity3208 ( @entity214 -PAGE): a single band corresponding to 115 Kd was observed for HMWSF, while LMWSF yielded a single band at 80 Kd. The isoelectric points (pI) of the different SFs was determined by flat-bed isoelectric-focusing: the HMWSF yielded a single band at pI 7.4, while a much lower pI was observed for LMWSF, 3.5-3.6. Studies on temperature lability indicated that both proteins are stable for 3-4 hours at room temperature (RT), 24-36 hours at +4 degrees C and 7-10 days at -80 degrees C.

title: [Immunosuppressive factors produced by a T cell line derived from XXXX ].

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia']

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium-dodecylsulfate']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

answer: @entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']


abstract: 1. The @entity26 consumption (VO2) of unrestrained @entity35 given a 'cafeteria' (high energy, high fat) or control diet was studied. The resting values of @entity4962 were the same in each dietary group, whether maintained at 26 degrees C or 6 degrees C. This negative finding suggests that cafeteria feeding is not an important cause of diet-induced thermogenesis (DIT). 2. The response of each group of @entity35 to injected @entity1063 or @entity935 was also studied. Each @entity2922 could increase VO2 values but the response was much less in cold-adapted @entity35 measured at 6 degrees C. In all experimental circumstances the @entity935 response exceeded that of @entity1063 . There was no evidence that the cafeteria diet consistently increased the response to either @entity2922 . 3. These results suggest that DIT cannot be equated with non-shivering thermogenesis (NST). Furthermore, it is suggested that @entity935 would be a better agent for measuring the @entity26 equivalent of NST, since it would stimulate the @entity935 receptors as well as the alpha- and beta-adrenoreceptors of brown fat.

title: Thermogenesis and the effect of injected catecholamines on the XXXX consumption of cafeteria-fed @entity35 .

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: 1. The @entity26 consumption (VO2) of unrestrained @entity35 given a 'cafeteria' (high energy, high fat) or control diet was studied. The resting values of @entity4962 were the same in each dietary group, whether maintained at 26 degrees C or 6 degrees C. This negative finding suggests that cafeteria feeding is not an important cause of diet-induced thermogenesis (DIT). 2. The response of each group of @entity35 to injected @entity1063 or @entity935 was also studied. Each @entity2922 could increase VO2 values but the response was much less in cold-adapted @entity35 measured at 6 degrees C. In all experimental circumstances the @entity935 response exceeded that of @entity1063 . There was no evidence that the cafeteria diet consistently increased the response to either @entity2922 . 3. These results suggest that DIT cannot be equated with non-shivering thermogenesis (NST). Furthermore, it is suggested that @entity935 would be a better agent for measuring the @entity26 equivalent of NST, since it would stimulate the @entity935 receptors as well as the alpha- and beta-adrenoreceptors of brown fat.

title: Thermogenesis and the effect of injected catecholamines on the @entity26 consumption of cafeteria-fed XXXX .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: Osteocalcin is a hormone with a complex cross-talk between adipose tissue and the skeleton. The aim of the present study was to explore the relation of osteocalcin with histopathological changes of NALFD @entity1 . SUBJECTS: A population of 69 @entity1561 @entity1 was analyzed. A liver biopsy was realized. Weight, fat mass, body mass index, basal @entity413 , @entity2690 , @entity2690 resistance (HOMA), total @entity165 , LDL @entity165 , HDL- @entity165 , @entity1674 and osteocalcin levels were measured. RESULTS: @entity1 were divided in two groups by median osteocalcin value (11.34 ng/mL), group I ( @entity1 with the low values) and group II ( @entity1 with the high values). Only liver @entity82 frequencies were different between groups (group I: 22.9% vs group II: 9.4%; p < 0.05). @entity1 in group I had higher levels of @entity413 (115.6    28.1 mg/dL vs. 103.7    24.3 mg/dL; p < 0.04), HOMA (4.6    3.1 units vs. 3.6    1.8 units; p < 0.04), weight (102.9    32.4 kg vs. 85.9    16.8 kg; p = 0.002) and body mass index (38.3    11.4 kg/m(2) vs. 30.1    5.7 kg/m(2); p = 0.001)) than @entity1 in group II. Osteocalcin was inverse correlated with @entity413 (r =-0.4; p = 0.002) and HOMA (r = -0.3:p = 0.01). CONCLUSION: Osteocalcin is associated with liver @entity82 . However, this association disappeared in a multivariate analysis, and HOMA remained as an independent factor.

title: Relation of osteocalcin with XXXX resistance and histopathological changes of non alcoholic fatty liver disease.

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity2690 :: (3630,Gene) :: ['insulin']


abstract: PURPOSE: The diagnostic value of endorectal coil MRI, body coil MRI, transrectal ultrasound, digital rectal examination and @entity1486 levels were prospectively analysed in order to define the most accurate preoperative staging method. METHODS: 33 @entity1 with @entity263 , who underwent subsequent prostatectomy, were enrolled in the study and examined on a 1.5T system using the body coil as well as the endorectal surface coil before and after the administration of contrast material. The results were compared to digital rectal examination, @entity1486 levels and endorectal ultrasound. RESULTS: Staging accuracy of endorectal coil MRI was 87.9% with a sensitivity of 88.9% and specificity of 86.7%. For body coil MRI, the staging accuracy was 75.7%, the sensitivity 66.7% and the specificity 87.9%, for transrectal ultrasound 69.6%, 41.7% and 100% and for the digital rectal examination 56.6%, 33.3% and 100%, respectively. Prediction was improved by combining results of endorectal coil MRI with @entity1486 values. CONCLUSION: Endorectal ultrasound and digital rectal examination both had a tendency to underestimate the extent of the lesion. Endorectal coil MRI proved to be the best preoperative staging method. In combination with @entity1486 values, diagnostic accuracy could be further improved. Therefore, local staging of @entity263 could be based on these two parameters alone.

title: Optimization of XXXX staging: comparison of imaging and clinical methods.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'prostate carcinoma']

entities_list: @entity1486 :: ('354', 'Gene') :: ['PSA', 'prostate specific antigen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate carcinoma']


abstract: A 76-year-old @entity1 was admitted to our hospital because of progressive @entity1353 , @entity221 , and consciousness disturbance. @entity3509 was diagnosed by chest image findings and laboratory findings of @entity1143 and serum. The @entity1 was first given an antimicrobial agent, and chest drainage was performed. Although his general condition improved, his @entity262 @entity32 and chest radiograph findings did not. Then, thoracoscopy under local anesthesia was considered. However, surgery was almost impossible, because he was hemiparetic, with mild conscious disturbance following @entity1779 . We decided to insert another drain into the thoracic cavity and continued to perform irrigation with saline in addition to the @entity262 administration of antibiotics for 3 weeks. His general condition gradually improved. Although the volume of drained fluid from the thoracic cavity decreased, the @entity75 did not completely disappear. We then performed irrigation with saline and urokinase for 3 days, from the 40th hospital day. Irrigation drainage using saline was more effective than previously, before urokinase administration; his symptoms and @entity75 markedly improved without antibiotics treatment. He was discharged on the 95th hospital day. For the treatment of chronic emypema, surgery using recently developed thoracoscopic techniques should be considered first, but may not be appropriate for frail elderly with severe @entity262 complications. Conventional intrathoracic irrigation using saline containing urokinase may be a treatment of choice for intractable @entity3509 in frail older @entity1 with @entity1158 caused by @entity385 .

title: [Successful treatment of thoracic drainage using urokinase for XXXX in an elderly @entity1 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusion']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['empyema lesions']

entities_list: @entity3509 :: ('MESH:D004653', 'Disease') :: ['empyema', 'Empyema']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hemorrhage']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity3509 :: (MESH:D004653,Disease) :: ['empyema']


abstract: A 76-year-old @entity1 was admitted to our hospital because of progressive @entity1353 , @entity221 , and consciousness disturbance. @entity3509 was diagnosed by chest image findings and laboratory findings of @entity1143 and serum. The @entity1 was first given an antimicrobial agent, and chest drainage was performed. Although his general condition improved, his @entity262 @entity32 and chest radiograph findings did not. Then, thoracoscopy under local anesthesia was considered. However, surgery was almost impossible, because he was hemiparetic, with mild conscious disturbance following @entity1779 . We decided to insert another drain into the thoracic cavity and continued to perform irrigation with saline in addition to the @entity262 administration of antibiotics for 3 weeks. His general condition gradually improved. Although the volume of drained fluid from the thoracic cavity decreased, the @entity75 did not completely disappear. We then performed irrigation with saline and urokinase for 3 days, from the 40th hospital day. Irrigation drainage using saline was more effective than previously, before urokinase administration; his symptoms and @entity75 markedly improved without antibiotics treatment. He was discharged on the 95th hospital day. For the treatment of chronic emypema, surgery using recently developed thoracoscopic techniques should be considered first, but may not be appropriate for frail elderly with severe @entity262 complications. Conventional intrathoracic irrigation using saline containing urokinase may be a treatment of choice for intractable @entity3509 in frail older @entity1 with @entity1158 caused by @entity385 .

title: [Successful treatment of thoracic drainage using urokinase for @entity3509 in an elderly XXXX ].

answer: @entity1 :: (9606,Species) :: ['man']


abstract: @entity1149 ( @entity1149 ) is characterized by brain @entity3 that occur in about 30 to 50% of @entity1 . To control @entity5 growth potential with maintaining neurocognitive function is important in the recent radiotherapy against brain @entity3 . From this viewpoint, we investigated the utility of repeat stereotactic radiosurgery (SRS) with a linear accelerator in the management of brain @entity3 from @entity1149 . Between October 1998 and May 2010, 28 @entity1 harboring brain @entity3 received repeat SRS (20 @entity1 and 8 @entity1 , with the age ranged from 51 to 79). The total number of SRS sessions ranged from 2 to 5, and the total number of lesions in one @entity1 ranged from 1 to 8. @entity16 due to uncontrolled @entity75 was identified in 9 of 28 @entity1 after the repeat SRS, while the remaining 19 @entity1 showed no neurological decline. Out of the 28 @entity1 , 18 @entity1 died by July 1, 2010; 12 @entity1 died of active @entity85 and 6 @entity1 died from progressive @entity75 , considered @entity16 . The 2-year and 4-year overall survival rates were 51% and 23%, respectively, and the median survival time was 26 months. In conclusion, repeat SRS is a preferred option to manage brain @entity3 from @entity1149 , leading to a long survival with a decreased neurological decline. Repeat SRS is promising to preserve neurocognition, because the convergent dose distribution decreases the unfavorable influences from radiation on germinal niches, thereby preserving neural stem cells that are responsible for the nervous system repair.

title: Repeat stereotactic radiosurgery in the management of brain @entity3 from XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesions']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurological decline', 'neurological death']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'Non-small cell lung cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['extracranial disease']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']


abstract: @entity1149 ( @entity1149 ) is characterized by brain @entity3 that occur in about 30 to 50% of @entity1 . To control @entity5 growth potential with maintaining neurocognitive function is important in the recent radiotherapy against brain @entity3 . From this viewpoint, we investigated the utility of repeat stereotactic radiosurgery (SRS) with a linear accelerator in the management of brain @entity3 from @entity1149 . Between October 1998 and May 2010, 28 @entity1 harboring brain @entity3 received repeat SRS (20 @entity1 and 8 @entity1 , with the age ranged from 51 to 79). The total number of SRS sessions ranged from 2 to 5, and the total number of lesions in one @entity1 ranged from 1 to 8. @entity16 due to uncontrolled @entity75 was identified in 9 of 28 @entity1 after the repeat SRS, while the remaining 19 @entity1 showed no neurological decline. Out of the 28 @entity1 , 18 @entity1 died by July 1, 2010; 12 @entity1 died of active @entity85 and 6 @entity1 died from progressive @entity75 , considered @entity16 . The 2-year and 4-year overall survival rates were 51% and 23%, respectively, and the median survival time was 26 months. In conclusion, repeat SRS is a preferred option to manage brain @entity3 from @entity1149 , leading to a long survival with a decreased neurological decline. Repeat SRS is promising to preserve neurocognition, because the convergent dose distribution decreases the unfavorable influences from radiation on germinal niches, thereby preserving neural stem cells that are responsible for the nervous system repair.

title: Repeat stereotactic radiosurgery in the management of brain XXXX from @entity1149 .

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastases']


abstract: Prevalence of @entity308 is high among poor, young, Hispanic inner city @entity1 . Depot- @entity11796 ( @entity12135 ) is a popular contraceptive choice in this group. @entity12135 labelling suggests that @entity308 may worsen with use. In order to identify any association of @entity12135 use with worsening @entity308 , we surveyed an English-speaking subset of @entity12135 users in a Title-X funded family planning clinic. Eighty @entity1 completed the CES-D scale on two occasions: once about four weeks after a @entity12135 injection when the subject would have been exposed to the highest blood levels, and once immediately prior to an injection when recent blood levels of the drug would be somewhat lower (or absent preceding the first injection). The median CES-D score was 14. The scores were not related to timing of the test (pre- or post-injection). The @entity308 scores were somewhat higher among those @entity1 receiving their first @entity12135 injection during the study period (i.e., unexposed @entity1 ) and among those @entity1 who had received four or more injections. Scores were unrelated to age or parity, but were somewhat higher in @entity1 who reported fewer years of education or a recent adverse pregnancy outcome. These data provide little evidence of increasing @entity308 with long-term use of @entity12135 and no evidence of a short-term effect of dose (within the contraceptive range) on mood. @entity1 at risk of @entity308 should not be denied @entity12135 as a contraceptive choice.

title: XXXX in users of @entity11796 .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: Prevalence of @entity308 is high among poor, young, Hispanic inner city @entity1 . Depot- @entity11796 ( @entity12135 ) is a popular contraceptive choice in this group. @entity12135 labelling suggests that @entity308 may worsen with use. In order to identify any association of @entity12135 use with worsening @entity308 , we surveyed an English-speaking subset of @entity12135 users in a Title-X funded family planning clinic. Eighty @entity1 completed the CES-D scale on two occasions: once about four weeks after a @entity12135 injection when the subject would have been exposed to the highest blood levels, and once immediately prior to an injection when recent blood levels of the drug would be somewhat lower (or absent preceding the first injection). The median CES-D score was 14. The scores were not related to timing of the test (pre- or post-injection). The @entity308 scores were somewhat higher among those @entity1 receiving their first @entity12135 injection during the study period (i.e., unexposed @entity1 ) and among those @entity1 who had received four or more injections. Scores were unrelated to age or parity, but were somewhat higher in @entity1 who reported fewer years of education or a recent adverse pregnancy outcome. These data provide little evidence of increasing @entity308 with long-term use of @entity12135 and no evidence of a short-term effect of dose (within the contraceptive range) on mood. @entity1 at risk of @entity308 should not be denied @entity12135 as a contraceptive choice.

title: @entity308 in users of XXXX .

answer: @entity11796 :: (MESH:D017258,Chemical) :: ['depo-medroxyprogesterone acetate']


abstract: BACKGROUND: @entity5 is a major public health problem in India. A key factor that has led to lack of improvement in prognosis of @entity5 over the years, is delay in diagnosis and treatment. In many instances, a significant proportion of oral @entity957 develop from @entity75 and conditions. Identification of such lesions and conditions is very important in order to prevent @entity5 . The role of @entity364 has been studied and holds promise as an indicator to predict @entity5 . So we designed a study to analyze the prevalence of fungal hyphae in biopsies of @entity1 with clinically diagnosed cases of @entity75 and conditions. AIMS AND OBJECTIVES: To determine and compare the prevalence of fungal hyphae in biopsies of @entity1 with clinically diagnosed cases of potentially malignant lesions and conditions and to assess the possible association between the degree of @entity5115 and presence or absence of fungal hyphae. MATERIALS AND METHODS: Clinically suspected and histopathologically diagnosed 70 cases of potentially malignant lesions and conditions (29 @entity12120 , 16 @entity82 and 25 lichen planus) made up the study group. Three tissue sections (5 m) of each were stained with @entity1710 and @entity1711 (H and E), periodic acid- @entity9376 (PAS) and Grocott's @entity1332 silver (GMS) and evaluated for fungal hyphae. The data collected was statistically analyzed by using Chi-square test and Statistical Package for Social Sciences (SPSS) software. RESULTS: The estimated prevalence of fungal hyphae in cases with or without @entity1141 in @entity12120 was 41.4%, lichen planus 36% and @entity82 25%. There was a significant association between degree of @entity5115 with presence or absence of fungal hyphae in all the study groups. CONCLUSION: Presence of fungal hyphae in potentially malignant lesions and conditions may prove to be a useful indicator in predicting @entity5 .

title: Prevalence of fungal hyphae in potentially malignant lesions and conditions-does its occurrence play a role in XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity9376 :: ('MESH:C476677', 'Chemical') :: ["Schiff's reagent"]

entities_list: @entity5115 :: ('MESH:C567703', 'Disease') :: ['epithelial dysplasia']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['submucous fibrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Oral cancer', 'oral cancer', 'malignant transformation']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['premalignant lesions']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity12120 :: ('MESH:D007971', 'Disease') :: ['leukoplakia']

entities_list: @entity1332 :: ('MESH:D008709', 'Chemical') :: ['methenamine']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity5115 :: (MESH:C567703,Disease) :: ['epithelial dysplasia']


abstract: CONTEXT: @entity2521 is predominantly due to exaggerated host response to pathogenic microorganisms and their products which causes an imbalance between the reactive @entity26 species-antioxidant in gingival crevicular fluid (GCF). @entity2041 is an important redox regulator in GCF and maintenance of stable @entity2041 ( @entity6172 ): @entity9492 ( @entity9492 ) ratio is essential for periodontal health. AIMS: The present study was undertaken to evaluate and compare the level of @entity2041 and redox balance ( @entity6172 : @entity9492 ratio) in GCF of @entity7278 @entity1 , periodontally healthy controls and also to evaluate the effect of nonsurgical periodontal therapy on the level of @entity2041 and redox balance during 3 months postoperative visit. STUDY DESIGN: Baseline GCF samples were collected from 20 @entity7278 @entity1 and 20 periodontally healthy subjects for @entity6172 and @entity9492 levels estimation. @entity2521 @entity1 were recalled 3 months postnonsurgical periodontal therapy to re-sample GCF. MATERIALS AND METHODS: @entity6172 and @entity9492 levels were measured by high-performance liquid chromatography. The values were statistically analyzed by Paired t-test. RESULTS: The mean @entity6172 and @entity9492 values in GCF were found to be significantly lower in @entity2521 @entity1 pre- and 3 months post-nonsurgical periodontal therapy, compared with those in the control group subjects. In addition, the successful nonsurgical therapy even though leading to a significant improvement in the @entity6172 and @entity9492 levels, does not restore @entity2041 concentration to the levels seen in healthy subjects. CONCLUSION: Successful nonsurgical periodontal therapy leads to significant improvement in the redox balance ( @entity6172 : @entity9492 ratio) in @entity7278 @entity1 .

title: Evaluation of @entity2041 level in gingival crevicular fluid in periodontal health, in XXXX and after nonsurgical periodontal therapy: A clinicobiochemical study.

entities_list: @entity9492 :: ('MESH:D019803', 'Chemical') :: ['GSSG', 'oxidized glutathione']

entities_list: @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic periodontitis']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione', 'reduced glutathione', 'Glutathione']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis', 'Periodontitis']

answer: @entity7278 :: (MESH:D055113,Disease) :: ['chronic periodontitis']


abstract: CONTEXT: @entity2521 is predominantly due to exaggerated host response to pathogenic microorganisms and their products which causes an imbalance between the reactive @entity26 species-antioxidant in gingival crevicular fluid (GCF). @entity2041 is an important redox regulator in GCF and maintenance of stable @entity2041 ( @entity6172 ): @entity9492 ( @entity9492 ) ratio is essential for periodontal health. AIMS: The present study was undertaken to evaluate and compare the level of @entity2041 and redox balance ( @entity6172 : @entity9492 ratio) in GCF of @entity7278 @entity1 , periodontally healthy controls and also to evaluate the effect of nonsurgical periodontal therapy on the level of @entity2041 and redox balance during 3 months postoperative visit. STUDY DESIGN: Baseline GCF samples were collected from 20 @entity7278 @entity1 and 20 periodontally healthy subjects for @entity6172 and @entity9492 levels estimation. @entity2521 @entity1 were recalled 3 months postnonsurgical periodontal therapy to re-sample GCF. MATERIALS AND METHODS: @entity6172 and @entity9492 levels were measured by high-performance liquid chromatography. The values were statistically analyzed by Paired t-test. RESULTS: The mean @entity6172 and @entity9492 values in GCF were found to be significantly lower in @entity2521 @entity1 pre- and 3 months post-nonsurgical periodontal therapy, compared with those in the control group subjects. In addition, the successful nonsurgical therapy even though leading to a significant improvement in the @entity6172 and @entity9492 levels, does not restore @entity2041 concentration to the levels seen in healthy subjects. CONCLUSION: Successful nonsurgical periodontal therapy leads to significant improvement in the redox balance ( @entity6172 : @entity9492 ratio) in @entity7278 @entity1 .

title: Evaluation of XXXX level in gingival crevicular fluid in periodontal health, in @entity7278 and after nonsurgical periodontal therapy: A clinicobiochemical study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity2041 :: (MESH:D005978,Chemical) :: ['glutathione']


abstract: OBJECTIVES: We evaluated the biological interaction between blood pressure (BP) and uterine artery Doppler (UAD) in the second trimester for early-onset @entity1468 (EO-PE) risk. STUDY DESIGN: A prospective cohort study. MAIN OUTCOME MEASURES: In 2410 pregnant @entity1 , mean pulsatility index (mPI) and mean notch depth index (mNDI) were examined by UAD at 16-23weeks' gestation. We defined EO-PE as PE with onset at <34weeks, abnormal UAD as coexistence of mPI   90th percentile and mNDI   90th percentile, and high BP as systolic BP/diastolic BP   120/80mmHg. Abnormal UAD and high BP were combined as a series of dummy variables, and were entered into a logistic regression model. The relative excess risk due to biological interaction (RERI) was calculated using the following equation: RERI=odds ratio (OR) in @entity1 with both high BP and abnormal UAD - OR in @entity1 with high BP alone - OR in @entity1 with abnormal UAD alone +1. RERI   10 was considered as strong. RESULTS: EO-PE and @entity32889 ( @entity32889 ) occurred in 1.1% and 1.2%, respectively. Adjusted odds ratio (95% CI) in @entity1 with abnormal UAD alone, high BP alone, and both high BP and abnormal UAD for predicting EO-PE was 4.3 (0.37-49), 12 (2.6-55) and 85 (17-422), respectively; and that for predicting @entity32889 was 6.3 (1.5-27), 6.1 (2.1-17) and 15 (3.6-61), respectively. The RERI for EO-PE and @entity32889 was 70 and 3.3, respectively. CONCLUSION: High BP and abnormal UAD may have a strong biological interaction for the occurrence of EO-PE.

title: Biophysical interaction between blood pressure and uterine artery Doppler for the occurrence of early-onset XXXX : A prospective cohort study.

entities_list: @entity32889 :: ('MESH:C537877', 'Disease') :: ['LO-PE', 'late-onset PE']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']

answer: @entity1468 :: (MESH:D011225,Disease) :: ['preeclampsia']


abstract: Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of @entity842 in nasal cavity air ( @entity33223 ) is influenced by @entity2023 and/or @entity1244 , both of which are common causes of UACS. We measured @entity33223 levels in @entity1 with UACS and those with other causes. We also examined the usefulness of measuring @entity33223 for differentiating @entity1 with @entity1244 from those without @entity1244 . The study included 93 adult @entity1 with prolonged cough lasting more than threeweeks. Etiologies of cough were identified and @entity33223 was measured at the initial investigation. UACS was diagnosed in 58 @entity1 (62.4%), and @entity1244 was identified in 11 (19.0%) of the 58 @entity1 with UACS. Levels of @entity33223 in UACS did not differ from non-UACS etiologies (316.2  129.2 vs. 334.9  88.2 ppb; p=0.452), suggesting that the measurement of @entity33223 could not discriminate UACS from other etiologies of prolonged cough. However, @entity1 with @entity1244 showed significantly decreased @entity33223 levels (190.1  114.8ppb) compared with @entity1 with UACS without @entity1244 (345.7  114.6ppb; p<0.001) and non-UACS @entity1 (334.9  88.2 ppb; p<0.001). In a receiver operating characteristic curve analysis for the diagnosis of @entity1244 in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a @entity33223 cutoff value of 279.0 ppb. These findings imply that the measurement of @entity33223 could be useful for diagnosis of prolonged cough associated with @entity1244 .

title: Measurement of nasal @entity842 is useful for the diagnosis of XXXX -induced prolonged cough.

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['allergic rhinitis']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

answer: @entity1244 :: (MESH:D012852,Disease) :: ['sinusitis']


abstract: Upper airway cough syndrome (UACS), the most common cause of prolonged cough, is diagnosed based on clinical findings without specific diagnostic test. The concentration of @entity842 in nasal cavity air ( @entity33223 ) is influenced by @entity2023 and/or @entity1244 , both of which are common causes of UACS. We measured @entity33223 levels in @entity1 with UACS and those with other causes. We also examined the usefulness of measuring @entity33223 for differentiating @entity1 with @entity1244 from those without @entity1244 . The study included 93 adult @entity1 with prolonged cough lasting more than threeweeks. Etiologies of cough were identified and @entity33223 was measured at the initial investigation. UACS was diagnosed in 58 @entity1 (62.4%), and @entity1244 was identified in 11 (19.0%) of the 58 @entity1 with UACS. Levels of @entity33223 in UACS did not differ from non-UACS etiologies (316.2  129.2 vs. 334.9  88.2 ppb; p=0.452), suggesting that the measurement of @entity33223 could not discriminate UACS from other etiologies of prolonged cough. However, @entity1 with @entity1244 showed significantly decreased @entity33223 levels (190.1  114.8ppb) compared with @entity1 with UACS without @entity1244 (345.7  114.6ppb; p<0.001) and non-UACS @entity1 (334.9  88.2 ppb; p<0.001). In a receiver operating characteristic curve analysis for the diagnosis of @entity1244 in prolonged cough, the best sensitivity (73.2%) and specificity (81.8%) were obtained with a @entity33223 cutoff value of 279.0 ppb. These findings imply that the measurement of @entity33223 could be useful for diagnosis of prolonged cough associated with @entity1244 .

title: Measurement of nasal XXXX is useful for the diagnosis of @entity1244 -induced prolonged cough.

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: A 30-year-old @entity1 , who was diagnosed with Beh  et disease at 10 years of age, was hospitalized because of transient @entity1269 after presenting with high @entity221 . Brain MRI revealed @entity2806 in the area supplied by the anterior cerebral arteries. Analysis of cerebrospinal fluid (CSF) showed pleocytosis and a high @entity650 ( @entity650 ) concentration (668   pg/ml). The @entity1 was diagnosed with acute @entity385 associated with exacerbation of Beh  et disease. After initiation of corticosteroid therapy, his clinical symptoms improved, and the CSF @entity650 concentration decreased. One year later, the @entity1 developed high @entity221 . Brain MRI showed an @entity2806 in the right putamen, and CSF analysis showed an elevated @entity650 concentration (287   pg/ml). Brain CT angiography revealed @entity850 of the @entity6128 and occlusion of the right anterior cerebral artery, which had been well visualized one year previously. Involvement of the intracranial cerebral arteries in Beh  et disease is extremely rare. To the best of our knowledge, this is the first case report of a @entity1 with recurrent symptomatic @entity385 associated with high @entity221 , which suggests exacerbation of Beh  et disease.

title: A case of Beh  et disease developing recurrent XXXX .

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions', 'acute ischemic lesion']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['right hemiparesis']

entities_list: @entity6128 :: ('MESH:D020243', 'Disease') :: ['left anterior cerebral artery']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['fever and scrotal ulcers after the onset of transient left upper limb plegia', 'fever and scrotal ulcers']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke with fever and scrotal ulcers']


abstract: PURPOSE: Recent publications have reported contradictory results of pretreatment diffusion-weighted magnetic resonance imaging (DWI) for the prediction of chemoradiotherapeutic response in primary @entity957 of the head and neck ( @entity213 ). Therefore, we evaluated the diagnostic performance of DWI obtained with both standard (b = 0 and 1,000 s/mm(2)) and high (b = 0 and 2,000 s/mm(2)) b-values for predicting response to induction chemotherapy in HNSCCs. METHODS: For 25 @entity1 with primary @entity213 who underwent DWI with both standard and high b-values prior to treatment, we calculated corresponding apparent diffusion coefficient (ADC) maps. Regions of interest containing the @entity5 were drawn on every section of ADC maps and summated to make volume-based data of the entire @entity5 . Histogram parameters (mean ADC, kurtosis, and skewness) were correlated with treatment response using unpaired Student t test. Univariate and multivariate analysis of the ADC parameters, @entity1 age, sex, whole @entity5 volume, and T stage were also performed to predict @entity5 response to induction chemotherapy. RESULTS: Response to induction chemotherapy was good in 13 of the 25 @entity1 and poor in 12. The mean ADC values of good responders at standard b-value (ADC1000), 1.23    0.34 (* 10(-3) mm(2)/s), and high b-value (ADC2000), 0.62    0.14 (* 10(-3) mm(2)/s), were lower than those of poor responders (ADC1000, 1.32    0.28 [* 10(-3) mm(2)/s]; ADC2000, 0.76    0.15 [* 10(-3) mm(2)/s]), but significant difference was achieved only at the ADC2000 map (P = 0.02). In addition, mean @entity5 volume prior to treatment of good responders was smaller than that of poor responders. However, at multiple logistic regression analysis, only the mean ADC2000 value remained as a significant predictor of response to induction chemotherapy. CONCLUSION: DWI with high b-values (b = 0 and 2,000 s/mm(2)) as an assessment of ADC values may help predict @entity5 response to neoadjuvant chemotherapy for primary HNSCCs.

title: XXXX of the Head and Neck: Comparison of Diffusion-weighted MRI at b-values of 1,000 and 2,000 s/mm(2) to Predict Response to Induction Chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

answer: @entity957 :: (MESH:D002294,Disease) :: ['Squamous Cell Carcinoma']


abstract: AIM: This study aimed to explore the test-retest reliability of the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test for @entity72 ( @entity2196 [ @entity2438 ]), the concurrent validity of this test with the Vineland Adaptive Behavior Scales (VABS-II), and parents' perceptions of usability. METHOD: A convenience sample of @entity1 (n=39) was recruited nationally through disability organizations. Parents of young @entity1 aged 10 to 18  years (mean age 14y 10mo, SD 2y 8mo; 34 males, five females) who reported a diagnosis of @entity2438 were eligible to participate. Parents completed the VABS-II questionnaire once and the @entity2196 ( @entity2438 ) twice (n=29) no more than 3  weeks apart (mean 12d) using computer-simulated administration. Parents also answered questions about the usability of these instruments. We examined score reliability using intraclass correlation coefficients (ICCs) and we explored the relationship between instruments using Spearman's rank correlation coefficients. Parent responses were grouped by common content; content categories were triangulated by an additional reviewer. RESULTS: Intraclass correlation coefficients indicate excellent reliability for all @entity2196 ( @entity2438 ) domain scores (ICC>= 0.86). @entity2196 ( @entity2438 ) and VABS-II domain scores correlated as expected or stronger than expected (0.57-0.81). Parents reported that the computer-based @entity2196 ( @entity2438 ) was easy to use and included fewer irrelevant questions than the VABS-II instrument. INTERPRETATION: These findings suggest that the @entity2196 ( @entity2438 ) is a reliable assessment that parents can easily use. The @entity2196 ( @entity2438 ) operationalizes the International Classification of Function, Disability and Health for @entity1 and Youth constructs of 'activity' and 'participation', and this preliminary research suggests that the instrument's constructs are related to those of VABS-II.

title: Validity, reliability, and usability of the Pediatric Evaluation of Disability Inventory-Computer Adaptive Test for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'people', 'Children']

entities_list: @entity72 :: ('MESH:D002659', 'Disease') :: ['autism spectrum disorders']

answer: @entity72 :: (MESH:D002659,Disease) :: ['autism spectrum disorders']


abstract: BACKGROUND: A subgroup of young @entity1 with @entity72 ( @entity72 ) have significant @entity73 (phonology, grammar, vocabulary), although such impairments are not considered to be core symptoms of and are not unique to @entity72 . @entity1 with @entity10870 ( @entity10870 ) display similar @entity73 . Given evidence for phenotypic and possibly etiologic overlap between @entity10870 and @entity72 , it has been suggested that @entity73 @entity1 with @entity72 ( @entity72   +   @entity73 , ALI) may be characterized as having both @entity72 and @entity10870 . However, the extent to which the language phenotypes in @entity10870 and ALI can be viewed as similar or different depends in part upon the age of the individuals studied. The purpose of the current study is to examine differences in memory abilities, specifically those that are key "markers" of heritable @entity10870 , among young school-age @entity1 with @entity10870 , ALI, and @entity2438 ( @entity72   +   language normal). METHODS: In this cross-sectional study, three groups of @entity1 between ages 5 and 8 years participated: @entity10870 (n   =   18), ALI (n   =   22), and @entity2438 (n   =   20). A battery of cognitive, language, and @entity72 assessments was administered as well as a nonword repetition (NWR) test and measures of verbal memory, visual memory, and processing speed. RESULTS: NWR difficulties were more severe in @entity10870 than in ALI, with the largest effect sizes in response to nonwords with the shortest syllable lengths. Among @entity1 with @entity72 , NWR difficulties were not associated with the presence of impairments in multiple @entity72 domains, as reported previously. Verbal memory difficulties were present in both @entity10870 and ALI groups relative to @entity1 with @entity2438 . Performance on measures related to verbal but not visual memory or processing speed were significantly associated with the relative degree of @entity73 in @entity1 with @entity72 , supporting the role of verbal memory difficulties in @entity73 among early school-age @entity1 with @entity72 . CONCLUSIONS: The primary difference between @entity1 with @entity10870 and ALI was in NWR performance, particularly in repeating two- and three-syllable nonwords, suggesting that shared difficulties in early language learning found in previous studies do not necessarily reflect the same underlying mechanisms.

title: Memory in language-impaired @entity1 with and without XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['language impairments', 'language impairment', 'impairments in language', 'language-impaired']

entities_list: @entity10870 :: ('OMIM:606712', 'Disease') :: ['specific language impairment', 'SLI']

entities_list: @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorders']

answer: @entity2438 :: (MESH:D001321,Disease) :: ['autism']


abstract: BACKGROUND: A subgroup of young @entity1 with @entity72 ( @entity72 ) have significant @entity73 (phonology, grammar, vocabulary), although such impairments are not considered to be core symptoms of and are not unique to @entity72 . @entity1 with @entity10870 ( @entity10870 ) display similar @entity73 . Given evidence for phenotypic and possibly etiologic overlap between @entity10870 and @entity72 , it has been suggested that @entity73 @entity1 with @entity72 ( @entity72   +   @entity73 , ALI) may be characterized as having both @entity72 and @entity10870 . However, the extent to which the language phenotypes in @entity10870 and ALI can be viewed as similar or different depends in part upon the age of the individuals studied. The purpose of the current study is to examine differences in memory abilities, specifically those that are key "markers" of heritable @entity10870 , among young school-age @entity1 with @entity10870 , ALI, and @entity2438 ( @entity72   +   language normal). METHODS: In this cross-sectional study, three groups of @entity1 between ages 5 and 8 years participated: @entity10870 (n   =   18), ALI (n   =   22), and @entity2438 (n   =   20). A battery of cognitive, language, and @entity72 assessments was administered as well as a nonword repetition (NWR) test and measures of verbal memory, visual memory, and processing speed. RESULTS: NWR difficulties were more severe in @entity10870 than in ALI, with the largest effect sizes in response to nonwords with the shortest syllable lengths. Among @entity1 with @entity72 , NWR difficulties were not associated with the presence of impairments in multiple @entity72 domains, as reported previously. Verbal memory difficulties were present in both @entity10870 and ALI groups relative to @entity1 with @entity2438 . Performance on measures related to verbal but not visual memory or processing speed were significantly associated with the relative degree of @entity73 in @entity1 with @entity72 , supporting the role of verbal memory difficulties in @entity73 among early school-age @entity1 with @entity72 . CONCLUSIONS: The primary difference between @entity1 with @entity10870 and ALI was in NWR performance, particularly in repeating two- and three-syllable nonwords, suggesting that shared difficulties in early language learning found in previous studies do not necessarily reflect the same underlying mechanisms.

title: Memory in language-impaired XXXX with and without @entity2438 .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: The failure of medical therapy for @entity9111 may be followed by its perforation, a complication associated with high mortality. We assessed the role of percutaneous catheter drainage in management of the sequelae of @entity8016 in 13 critically ill @entity1 ; 22 intrahepatic lesions, three of which were multiloculated, were drained. Catheters were also placed in 17 extrahepatic collections: pleural space (n = 5), subphrenic (n = 7), perihepatic/subhepatic (n = 3), greater sac of peritoneum (n = 2). No attempt at percutaneous drainage failed. Prompt resolution of clinical features following drainage was a uniform feature. Successful resolution of the abscesses occurred within 20 days in 11 @entity1 . In the remaining two, catheters needed to be retained in situ for 35 and 50 days. The mean hospital stay was 15 days (range 10-20 days). 100% @entity1 survival was achieved, without a single morbid episode. Our results suggest that @entity1 with @entity8016 can be effectively and safely managed by percutaneous catheter drainage irrespective of the extent of extrahepatic contamination.

title: XXXX : the role of percutaneous catheter drainage.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity9111 :: ('MESH:D008101', 'Disease') :: ['amebic liver abscess']

entities_list: @entity8016 :: ('MESH:D000562', 'Disease') :: ['ruptured amebic abscesses']

answer: @entity9111 :: (MESH:D008101,Disease) :: ['Complex ruptured amebic liver abscesses']


abstract: The @entity1 lower esophageal sphincter (LES) is believed to be innervated by nonadrenergic, noncholinergic inhibitory nerves, and cholinergic excitatory nerves. In idiopathic @entity1318 , LES relaxation is abnormal because the inhibitory nerves to the sphincter are either absent or functionally impaired. The integrity of cholinergic excitatory nerves to the LES, however, has not been thoroughly evaluated. In 27 @entity1 with untreated idiopathic @entity1318 , and 21 healthy volunteers, we investigated the hypothesis that postganglionic cholinergic nerves to the LES are functionally intact in @entity1318 . The LES responses to @entity3897 , @entity4560 , @entity2710 , @entity3586 , and @entity10026 were assessed. In 2 @entity1318 @entity1 , patterns of fasting motor activity in the LES were investigated during overnight manometric studies. Resting LES pressure was significantly greater in the @entity1318 @entity1 , 41 +/- 4 mmHg (mean +/- SE), than in the normal subjects, 20 +/- 2 mmHg. @entity3897 significantly reduced LES pressure in both groups by 30%-75%. @entity4560 increased LES pressure in the @entity1318 @entity1 but had negligible effect on the normal subjects. The LES in @entity1318 @entity1 exhibited an increased sensitivity to both @entity2710 and @entity10026 compared with the normal subjects. In both @entity1 who underwent an overnight manometric study, the LES exhibited cyclic phasic contractile activity synchronous with gastric contractions during the migrating motor complex. We conclude that the study findings support the hypothesis that postganglionic cholinergic LES innervation in @entity1318 @entity1 is either normal or only minimally impaired, in contrast to the marked impairment of the inhibitory nerves governing LES relaxation.

title: Integrity of cholinergic innervation to the lower esophageal sphincter in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia']

entities_list: @entity10026 :: ('MESH:D010418', 'Chemical') :: ['pentagastrin']

entities_list: @entity4560 :: ('MESH:D004491', 'Chemical') :: ['Edrophonium', 'edrophonium']

entities_list: @entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine', 'atropine']

entities_list: @entity3586 :: ('MESH:D000680', 'Chemical') :: ['amyl nitrite']

entities_list: @entity2710 :: ('MESH:D016210', 'Chemical') :: ['methacholine']

answer: @entity1318 :: (MESH:D004931,Disease) :: ['achalasia']


abstract: Polyfunctional @entity30383 ( @entity10461 ) is increasingly used as a water-based @entity2483 , paint primers, lacquers, topcoats and other protective coatings. The crosslinker is made by reacting multifunctional acrylic monomer with a highly reactive @entity30383 compound. @entity1576 or @entity56 from @entity10461 has not been reported previously. During 1978-1991 we came across nine cases with @entity56 from @entity10461 : two had @entity3408 ( @entity3408 ), four had @entity7446 and three had both of them. Five of the @entity1 were parquet layers, two were fibreboard painters, one was a spray painter and one was a salesman of @entity10461 products. @entity3408 was diagnosed by positive allergic patch test reactions with @entity10461 in a dilution series in petrolatum: 0.32%-0.5% gave a 2(+)-3+ @entity56 in the five cases with @entity3408 but 0.1% gave only a weak reaction in one case, whereas the @entity11379 patch test series was negative. The diagnosis of seven cases of @entity7446 due to @entity10461 hardener was based on symptoms related to exposure to @entity10461 hardener at work, and on positive provocation tests with @entity10461 hardener. One had an immediate type reaction, one a had a dual reaction, and the others had late reactions. The positive reactions with the @entity10461 hardener and the negative reactions with the @entity3678 compounds indicate that @entity10461 caused @entity3408 which is different from the previous reports in which acrylates present as impurities in the @entity10461 hardener caused the sensitization.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Occupational @entity1576 caused by polyfunctional XXXX hardener.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3408 :: ('MESH:D017449', 'Disease') :: ['ACD', 'allergic contact dermatitis']

entities_list: @entity11379 :: ('CHEBI:25218', 'Chemical') :: ['methacrylate']

entities_list: @entity3678 :: ('MESH:C036658', 'Chemical') :: ['acrylate']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic reaction', 'hypersensitivity']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['Respiratory allergy']

entities_list: @entity30383 :: ('MESH:C033132', 'Chemical') :: ['aziridine']

entities_list: @entity2483 :: ('MESH:C566443', 'Disease') :: ['crosslinker in two-component paints']

entities_list: @entity7446 :: ('MESH:D059366', 'Disease') :: ['occupational asthma']

answer: @entity30383 :: (MESH:C033132,Chemical) :: ['aziridine']


abstract: Polyfunctional @entity30383 ( @entity10461 ) is increasingly used as a water-based @entity2483 , paint primers, lacquers, topcoats and other protective coatings. The crosslinker is made by reacting multifunctional acrylic monomer with a highly reactive @entity30383 compound. @entity1576 or @entity56 from @entity10461 has not been reported previously. During 1978-1991 we came across nine cases with @entity56 from @entity10461 : two had @entity3408 ( @entity3408 ), four had @entity7446 and three had both of them. Five of the @entity1 were parquet layers, two were fibreboard painters, one was a spray painter and one was a salesman of @entity10461 products. @entity3408 was diagnosed by positive allergic patch test reactions with @entity10461 in a dilution series in petrolatum: 0.32%-0.5% gave a 2(+)-3+ @entity56 in the five cases with @entity3408 but 0.1% gave only a weak reaction in one case, whereas the @entity11379 patch test series was negative. The diagnosis of seven cases of @entity7446 due to @entity10461 hardener was based on symptoms related to exposure to @entity10461 hardener at work, and on positive provocation tests with @entity10461 hardener. One had an immediate type reaction, one a had a dual reaction, and the others had late reactions. The positive reactions with the @entity10461 hardener and the negative reactions with the @entity3678 compounds indicate that @entity10461 caused @entity3408 which is different from the previous reports in which acrylates present as impurities in the @entity10461 hardener caused the sensitization.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Occupational XXXX caused by polyfunctional @entity30383 hardener.

answer: @entity1576 :: (MESH:D012131,Disease) :: ['respiratory and skin sensitization']


abstract: BACKGROUND: Childhood adversities have been associated with adult @entity2704 in the general population. However, most research has focused on only a few types of maltreatment and has not always controlled for factors correlated with early adversities and @entity2704 . OBJECTIVES: The aim of this study was to investigate the relationship between early adversities and @entity2704 , while controlling for a range of potential explanatory factors. METHODS: We analyzed data from the 2012 Canadian Community Health Survey - Mental Health. Using a representative sample of 10,358 @entity1 and 12,638 @entity1 , we undertook gender-specific logistic regression analyses to determine the association between number and type of self-reported childhood adversities (physical abuse, @entity458 , and witnessing parental domestic violence) and @entity2704 , while controlling for sociodemographics, comorbid adversities, health behaviors, @entity308 , and @entity148 . RESULTS: In total, 6.5% of @entity1 and 14.2% of @entity1 reported @entity2704 . All three adversities were significantly associated with @entity2704 for both genders, even after controlling for a range of variables. The fully adjusted odds of @entity2704 associated with physical abuse, parental domestic violence, and @entity458 were 1.61 (95% confidence interval [CI]   =   1.42-1.83), 1.64 (95% CI   =   1.39-1.93), and 1.32 (95% CI   =   1.11-1.57), respectively, for @entity1 , and 1.50 (95% CI   =   1.25-1.80), 1.52 (95% CI   =   1.16-1.98), and 1.70 (95% CI   =   1.22-2.36) for @entity1 . Greater number of adversities was also associated with increasing odds of @entity2704 . @entity1 reporting all three adversities had over three times (odds ratio   =   3.26; 95% CI   =   2.09-5.07) and @entity1 over two times (OR   =   2.85; 95% CI   =   2.25-3.60) the odds of @entity2704 compared with those without childhood adversities. CONCLUSIONS: Number and type of early adversities are associated with @entity2704 among Canadian @entity1 and @entity1 .

title: The Painful Legacy of Childhood Violence: XXXX Among Adult Survivors of Adverse Childhood Experiences.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual abuse']

entities_list: @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine', 'migraines']

answer: @entity2704 :: (MESH:D008881,Disease) :: ['Migraine Headaches']


abstract: BACKGROUND: Biological studies on megakaryopoiesis have been hampered by the scarcity of megakaryocytes in normal bone marrow and difficulty in long term culture. Alternatively, @entity1778 cell lines with megakaryocytic differentiation potential may provide good models to counter these problems. METHODS: Leukemic cells from a @entity1 with @entity10706 were put into long-term culture and established into a cell line which was designated as VGH-MK1. The VGH-MK1 cells were challenged with differentiation agents and/or cytokines, and the differentiation of these cells was examined using morphological, immunocytochemical and surface-marker studies. RESULTS: Morphologically, VGH-MK1 cells had prominent nucleoli and basophilic cytoplasm with some protrusions, but large cells were occasionally seen. Under regular culture condition, the cells had a doubling time of 36-48 hours. The cloned cell line exhibited markers characteristic of megakaryoblasts after differentiation induction. Specifically, when stimulated with @entity864 ( @entity865 ), cells became larger and had large or multinuclei. They were induced to express platelet glycoproteins GPIb ( @entity27463 ), @entity1427 /IIIa ( @entity1427 ), and @entity1428 ( @entity1428 ) antigens, but not erythroid nor lymphoid markers. Platelet peroxidase (PPO) activity was also induced. @entity1968 did not exhibit similar differentiation-inducing effects. In contrast, it counteracted the effects induced by @entity865 . CONCLUSIONS: An unique @entity1 @entity1778 cell line, VGH-MK1, has been established here. It could be induced to exhibit some characteristics of megakaryocytic lineage, and may be an useful model for the biological studies of megakaryopoiesis.

title: Induction of megakaryocytic differentiation in a newly established @entity1 @entity1778 cell line by XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity10706 :: ('MESH:D007947', 'Disease') :: ['acute megakaryocytic leukemia']

entities_list: @entity864 :: ('MESH:C554292|MESH:D013755', 'Chemical') :: ['12-o-tetradecanoylphorbol-13-acetate']

entities_list: @entity1968 :: ('MESH:D014212', 'Chemical') :: ['Retinoic acid']

answer: @entity864 :: (MESH:C554292|MESH:D013755,Chemical) :: ['12-o-tetradecanoylphorbol-13-acetate']


abstract: BACKGROUND: Biological studies on megakaryopoiesis have been hampered by the scarcity of megakaryocytes in normal bone marrow and difficulty in long term culture. Alternatively, @entity1778 cell lines with megakaryocytic differentiation potential may provide good models to counter these problems. METHODS: Leukemic cells from a @entity1 with @entity10706 were put into long-term culture and established into a cell line which was designated as VGH-MK1. The VGH-MK1 cells were challenged with differentiation agents and/or cytokines, and the differentiation of these cells was examined using morphological, immunocytochemical and surface-marker studies. RESULTS: Morphologically, VGH-MK1 cells had prominent nucleoli and basophilic cytoplasm with some protrusions, but large cells were occasionally seen. Under regular culture condition, the cells had a doubling time of 36-48 hours. The cloned cell line exhibited markers characteristic of megakaryoblasts after differentiation induction. Specifically, when stimulated with @entity864 ( @entity865 ), cells became larger and had large or multinuclei. They were induced to express platelet glycoproteins GPIb ( @entity27463 ), @entity1427 /IIIa ( @entity1427 ), and @entity1428 ( @entity1428 ) antigens, but not erythroid nor lymphoid markers. Platelet peroxidase (PPO) activity was also induced. @entity1968 did not exhibit similar differentiation-inducing effects. In contrast, it counteracted the effects induced by @entity865 . CONCLUSIONS: An unique @entity1 @entity1778 cell line, VGH-MK1, has been established here. It could be induced to exhibit some characteristics of megakaryocytic lineage, and may be an useful model for the biological studies of megakaryopoiesis.

title: Induction of megakaryocytic differentiation in a newly established @entity1 XXXX cell line by @entity864 .

answer: @entity1778 :: (MESH:D007938,Disease) :: ['leukemic']


abstract: BACKGROUND: Biological studies on megakaryopoiesis have been hampered by the scarcity of megakaryocytes in normal bone marrow and difficulty in long term culture. Alternatively, @entity1778 cell lines with megakaryocytic differentiation potential may provide good models to counter these problems. METHODS: Leukemic cells from a @entity1 with @entity10706 were put into long-term culture and established into a cell line which was designated as VGH-MK1. The VGH-MK1 cells were challenged with differentiation agents and/or cytokines, and the differentiation of these cells was examined using morphological, immunocytochemical and surface-marker studies. RESULTS: Morphologically, VGH-MK1 cells had prominent nucleoli and basophilic cytoplasm with some protrusions, but large cells were occasionally seen. Under regular culture condition, the cells had a doubling time of 36-48 hours. The cloned cell line exhibited markers characteristic of megakaryoblasts after differentiation induction. Specifically, when stimulated with @entity864 ( @entity865 ), cells became larger and had large or multinuclei. They were induced to express platelet glycoproteins GPIb ( @entity27463 ), @entity1427 /IIIa ( @entity1427 ), and @entity1428 ( @entity1428 ) antigens, but not erythroid nor lymphoid markers. Platelet peroxidase (PPO) activity was also induced. @entity1968 did not exhibit similar differentiation-inducing effects. In contrast, it counteracted the effects induced by @entity865 . CONCLUSIONS: An unique @entity1 @entity1778 cell line, VGH-MK1, has been established here. It could be induced to exhibit some characteristics of megakaryocytic lineage, and may be an useful model for the biological studies of megakaryopoiesis.

title: Induction of megakaryocytic differentiation in a newly established XXXX @entity1778 cell line by @entity864 .

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: In treating severe @entity130 of the esophagus and stomach, prompt diagnosis, adequate fluid resuscitation and warranted surgical intervention are the most important factors in rescue of @entity3124 @entity1 . The purpose of this study was to evaluate the need for, and the advantages of, a surgical approach to treatment of such @entity130 to the upper gastrointestinal (UGI) tract, as well as to select the most suitable technique to achieve a good survival rate. METHODS: From January 1983 to December 1991, 220 @entity1 were treated for caustic ingestion injury to the UGI tract. A retrospective review of their records allowed targeting of 27 @entity1 with severe @entity130 that surgical intervention was required. In this study, peritoneal sign was taken as the key indicator for early emergency operation. The age, sex, elapsed time from injury to operation, the sort and quantity of caustic agent used, injury mechanism, clinical manifestations, alternative surgical treatment methods and causes of @entity204 were also reviewed and analyzed in this study. RESULTS: The @entity1 included 13 @entity1 and 14 @entity1 , of whom the majority were adults (96.3%) who had attempted suicide (85.2%). All of them had taken liquid corrosive agents, usually @entity5836 (63%). Eighteen underwent emergency operations; the other nine received only supportive treatment, given their terminal status. The mortality rates for @entity1 with surgery and supportive treatment were 66.7% and 100%, respectively. Four @entity1 died after undergoing esophagectomy with resection of the stomach using the thoracoabdominal method. Only three of the eight @entity1 who received esophageal stripping combined with resection of the stomach through the abdomen died (37.5%). CONCLUSIONS: The time elapsed between injury and development of peritoneal sign is a good indicator of the severity and extent of the injury. When peritoneal sign manifests at a very early stage, it is an indicator that the @entity130 is very advanced in its progress and that, no matter what procedures were performed, the outcome would be the same. Yet if there were a six-hour gap then aggressive surgical management can rescue some @entity1 . It is recommended based on experience here, that when using the surgical approach, resection of the stomach with stripping of the esophagus is superior to the thoracoabdominal method.

title: Emergency surgical intervention for severe XXXX of the upper digestive tract.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity5836 :: ('MESH:D006851', 'Chemical') :: ['hydrochloric acid']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['corrosive injury', 'corrosive injuries']

answer: @entity130 :: (MESH:D014947,Disease) :: ['corrosive injuries']


abstract: Recombinant @entity291 interferon-alpha I 1 ( @entity2920 ) was tested for effects on lymphocyte migration into and out of the lymph nodes of @entity742 . Chronic lymph drainage methods were used to monitor the efferent lymph of single lymph nodes of unanaesthetized animals. When @entity2920 was injected into the drainage area of the lymph node, infused directly via an afferent lymphatic, or injected intravenously, a marked decrease in cell output was observed. Nanogram quantities of @entity2920 produced an effect that lasted several hours. To test whether this effect was specific for lymphocytes, we first stimulated a lymph node with @entity794 so that large numbers of neutrophils and lymphocytes were present in efferent lymph. When @entity2920 was then injected, the lymphocytes disappeared from efferent lymph but the neutrophils did not. Normal efferent lymph cells were labeled with radioisotopes and injected intravenously during the @entity2920 induced effect. The entry of lymphocytes from the blood was significantly enhanced at a time coinciding with the suppressed cell exit in the efferent lymph. Recovery data indicated that the lymphocytes were retained temporarily in the lymph node but were not destroyed. Furthermore, the @entity291 @entity2920 does not appear to be conspicuously antigenic in @entity742 . It is not yet certain whether @entity2920 enhances the interactions of cells within the lymph node thereby potentiating immunologic reactions.

title: Recombinant XXXX interferon-alpha I 1 inhibits the migration of lymphocytes from lymph nodes but not into lymph nodes.

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: OBJECTIVE: The risk of developing @entity420 in @entity355 is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers. METHODS: In a prospective cohort of @entity1 with @entity355 , we evaluated six molecular markers: @entity986 , @entity876 , @entity1722 , 20q, @entity517 and aneusomy by DNA fluorescence in situ hybridisation on brush cytology specimens. Primary study outcomes were the development of high-grade @entity1141 or @entity420 . The most predictive clinical variables and markers were determined using Cox proportional-hazards models, receiver operating characteristic curves and a leave-one-out analysis. RESULTS: A total of 428 @entity1 participated (345 @entity1 ; median age 60   years) with a cumulative follow-up of 2019 @entity1 -years (median 45   months per @entity1 ). Of these @entity1 , 22 progressed; nine developed high-grade @entity1141 and 13 @entity420 . The clinical variables, age and circumferential Barrett's length, and the markers, @entity986 loss, @entity517 gain and aneusomy, were significantly associated with progression on univariate analysis. We defined an 'Abnormal Marker Count' that counted abnormalities in @entity986 , @entity517 and aneusomy, which significantly improved risk prediction beyond using just age and Barrett's length. In multivariate analysis, these three factors identified a high-risk group with an 8.7-fold (95% CI 2.6 to 29.8) increased HR when compared with the low-risk group, with an area under the curve of 0.76 (95% CI 0.66 to 0.86). CONCLUSIONS: A prediction model based on age, Barrett's length and the markers @entity986 , @entity517 and aneusomy determines progression risk in @entity355 .

title: Derivation of genetic biomarkers for cancer risk stratification in XXXX : a prospective cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["non-dysplastic Barrett's oesophagus"]

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['oesophageal adenocarcinoma', 'adenocarcinoma']

answer: @entity355 :: (MESH:D001471,Disease) :: ['Barrett's oesophagus']