abstract: @entity26 -evolving photosystem II complex was isolated from @entity2772 chloroplasts. The individual polypeptides of the complex were isolated from @entity3208 ( @entity214 )- @entity2975 gels and antibodies were raised in @entity95 against these polypeptides. After washing of the isolation complex by 0.8 M Tris to release the extrinsic proteins, a distinct diffused protein band was revealed at the position of 33 kDa in @entity214 gels containing 4 M @entity1133 . When this band was electroeluted from the gel and subsequently electrophoresed on @entity214 gels, three distinct protein bands became apparent. Antibodies raised against each one of these polypeptides cross-reacted with the other two polypeptides to varying degrees but not with the other subunits of the complex. The three polypeptides were denoted as "34," "33," and "32" kDa and the 33 being the herbicide-binding protein. Using the antibodies, the relative amounts of the photosystem II polypeptides were followed during greening of etiolated @entity2772 seedlings. While all three extrinsic polypeptides were present in etiolated leaves at relatively high amounts, the other polypeptides could not be detected prior to an approximate 6-h illumination period. Further illumination induced the appearance of all of the rest of the subunits in a relatively similar rate. The @entity26 evolution activity was developed parallel to the increase in the amounts of these polypeptides. Therefore, the assembly of the active photosystem II during greening is a two-step process in contrast with the photosystem I reaction center, which is assembled step by step, and the rest of the chloroplast protein complexes, which are assembled by a concerted mechanism.

title: Polypeptides of the XXXX -evolving photosystem II complex. Immunological detection and biogenesis.

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecyl sulfate']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen', 'Oxygen']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: OBJECTIVE: @entity459 ( @entity459 ) is often seen in conjunction with an underlying @entity1374 . Imaging methods that are used to localize the @entity3243 also detect associated thyroid nodules and @entity259 . The aim of this study was to detect the rate of @entity259 identified while performing parathyroidectomy and thyroidectomy in @entity1 with @entity459 . MATERIAL AND METHODS: Files of all @entity1 who were operated for @entity459 and who underwent simultaneous thyroidectomy were analyzed. Data regarding parathyroid pathology, surgical procedures, indications of thyroid surgery, and pathology results were retrospectively recorded. The indications for thyroid surgery included presence of suspicious thyroid nodules in ultrasonography, increase in size of thyroid nodules in follow-up ultrasound, or presence of suspicious thyroid fine needle aspiration biopsy (FNAB) findings. Rates of @entity259 detection were investigated according to definite pathology reports. RESULTS: Eighty-three @entity1 who underwent parathyroidectomy with a diagnosis of @entity459 with concurrent thyroidectomy in Department of General Surgery,   stanbul University   stanbul Faculty of Medicine were included in the study. Eighteen @entity1 were male (22%) and 65 were female (78%). The median age was 53 (18-70) years. The primary indication for parathyroidectomy was @entity459 in all @entity1 . The thyroid procedures applied in addition to parathyroidectomy were lobectomy + isthmusectomy in 29 @entity1 (35%), bilateral subtotal thyroidectomy in 20 @entity1 (24%), bilateral total thyroidectomy in 23 @entity1 (28%), and total thyroidectomy on one side and near total thyroidectomy to the other side in 11 @entity1 (13%). The only indication for thyroidectomy was the presence of thyroid nodules until 2000 (20 @entity1 , 24%). Indications in the remaining 63 @entity1 included the presence of multiple nodules that cannot be followed up by ultrasonography in 25 @entity1 (30%), presence of a suspicious nodule on ultrasonography in 33 @entity1 (40%), growth in nodule size in 2 @entity1 (2%), and detection of suspicious findings on FNAB in 3 @entity1 (4%). Five @entity1 (6%) were diagnosed with @entity3557 , four of whom were @entity5 . CONCLUSION: Imaging methods performed to localize the pathological parathyroid gland for a diagnosis of @entity459 are useful in estimating other accompanying pathologies. Presence of thyroid nodules should be evaluated before all parathyroid procedures, and if the nodule has an indication for surgery, thyroid surgery should be considered at the same operation with parathyroid surgery.

title: XXXX incidence in simultaneous thyroidectomy with parathyroid surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid cancer']

entities_list: @entity459 :: ('MESH:D049950', 'Disease') :: ['Primary hyperparathyroidism', 'primary hyperparathyroidism', 'PHPT']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['micropapillary cancer']

entities_list: @entity3243 :: ('MESH:D010282', 'Disease') :: ['parathyroid adenoma']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disorder']

answer: @entity259 :: (MESH:D013964,Disease) :: ['Thyroid cancer']


abstract: UNASSIGNED: @entity43 ( @entity43 ) is the most @entity5 due to its high recurrence rate following initial treatment. Previous studies have indicated that @entity5 stem cells (CSCs) may be a potential cause underlying the high proportion of recurrence. Side population (SP) cells isolated from @entity5 cell lines have been shown to exhibit characteristics associated with CSCs, but studies on SP cells in @entity1 ovarian SK-OV-3 cell line are limited. In the present study, the SP cell fraction (4.83% of the total cell population) was isolated using flow cytometry, and analyzed by immunocytochemical analysis and reverse transcription-quantitative polymerase chain reaction. The results showed that SP cells exhibited a high mean fluorescence intensity for @entity1759 , a CSC marker, in addition to elevated expression of the CSCs-associated genes, @entity855 -binding cassette sub-family G member 2 and Nestin. These findings indicated the stem cell-like features of the SP cells. Furthermore, a colony formation test showed that the isolated SP cells possessed a marked capacity for self-regeneration and proliferation. In addition, a cell cycle assay involving @entity900 indicated that the SP cells were strongly resistant to chemotherapy. In conclusion, the present results suggested that SP cells isolated from the SK-OV-3 cell line exhibited properties typically associated with CSCs. Therefore, the isolated SP cells may be used to provide novel insight into potential therapies against @entity43 .

title: Isolation and characterization of side population cells from the @entity1 XXXX cell line SK-OV-3.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['OC', 'Ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignant type of gynecological tumor']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: UNASSIGNED: @entity43 ( @entity43 ) is the most @entity5 due to its high recurrence rate following initial treatment. Previous studies have indicated that @entity5 stem cells (CSCs) may be a potential cause underlying the high proportion of recurrence. Side population (SP) cells isolated from @entity5 cell lines have been shown to exhibit characteristics associated with CSCs, but studies on SP cells in @entity1 ovarian SK-OV-3 cell line are limited. In the present study, the SP cell fraction (4.83% of the total cell population) was isolated using flow cytometry, and analyzed by immunocytochemical analysis and reverse transcription-quantitative polymerase chain reaction. The results showed that SP cells exhibited a high mean fluorescence intensity for @entity1759 , a CSC marker, in addition to elevated expression of the CSCs-associated genes, @entity855 -binding cassette sub-family G member 2 and Nestin. These findings indicated the stem cell-like features of the SP cells. Furthermore, a colony formation test showed that the isolated SP cells possessed a marked capacity for self-regeneration and proliferation. In addition, a cell cycle assay involving @entity900 indicated that the SP cells were strongly resistant to chemotherapy. In conclusion, the present results suggested that SP cells isolated from the SK-OV-3 cell line exhibited properties typically associated with CSCs. Therefore, the isolated SP cells may be used to provide novel insight into potential therapies against @entity43 .

title: Isolation and characterization of side population cells from the XXXX @entity43 cell line SK-OV-3.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: One-hundred thirty eligible @entity1 with advanced @entity14 who had received no prior chemotherapy were randomized to either @entity5498 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity1138 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity1487 ( @entity1487 ), 400 mg/m2 intravenously weekly--( @entity2098 )--or @entity1487 , 600 mg/m2 intravenously weekly ( @entity1487 ). One hundred twenty-six @entity1 are evaluable for response. Of 62 @entity1 treated with @entity2098 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity1 treated with @entity1487 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity1 receiving @entity2098 was 9.5 months compared with 10.3 months for @entity1 receiving @entity1487 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity1 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity2098 compared to @entity1487 therapy alone in advanced @entity14 . In addition, hematologic @entity137 was significantly greater with the combination ( @entity2098 ) regimen.

title: Combination chemotherapy ( @entity1487 , methyl-CCNU, XXXX ) versus @entity1487 alone for advanced previously untreated @entity14 . A phase III study of the Piedmont Oncology Association.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinoma', 'colorectal cancer']

answer: @entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin C']


abstract: One-hundred thirty eligible @entity1 with advanced @entity14 who had received no prior chemotherapy were randomized to either @entity5498 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity1138 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity1487 ( @entity1487 ), 400 mg/m2 intravenously weekly--( @entity2098 )--or @entity1487 , 600 mg/m2 intravenously weekly ( @entity1487 ). One hundred twenty-six @entity1 are evaluable for response. Of 62 @entity1 treated with @entity2098 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity1 treated with @entity1487 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity1 receiving @entity2098 was 9.5 months compared with 10.3 months for @entity1 receiving @entity1487 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity1 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity2098 compared to @entity1487 therapy alone in advanced @entity14 . In addition, hematologic @entity137 was significantly greater with the combination ( @entity2098 ) regimen.

title: Combination chemotherapy ( @entity1487 , methyl-CCNU, @entity1138 ) versus @entity1487 alone for advanced previously untreated XXXX . A phase III study of the Piedmont Oncology Association.

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']


abstract: One-hundred thirty eligible @entity1 with advanced @entity14 who had received no prior chemotherapy were randomized to either @entity5498 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity1138 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity1487 ( @entity1487 ), 400 mg/m2 intravenously weekly--( @entity2098 )--or @entity1487 , 600 mg/m2 intravenously weekly ( @entity1487 ). One hundred twenty-six @entity1 are evaluable for response. Of 62 @entity1 treated with @entity2098 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity1 treated with @entity1487 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity1 receiving @entity2098 was 9.5 months compared with 10.3 months for @entity1 receiving @entity1487 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity1 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity2098 compared to @entity1487 therapy alone in advanced @entity14 . In addition, hematologic @entity137 was significantly greater with the combination ( @entity2098 ) regimen.

title: Combination chemotherapy ( XXXX , methyl-CCNU, @entity1138 ) versus @entity1487 alone for advanced previously untreated @entity14 . A phase III study of the Piedmont Oncology Association.

answer: @entity1487 :: (MESH:D005472,Chemical) :: ['5-fluorouracil']


abstract: One-hundred thirty eligible @entity1 with advanced @entity14 who had received no prior chemotherapy were randomized to either @entity5498 -CCNU, 70 mg/m2 orally every 6 weeks on day 1, @entity1138 , 10 mg/m2 intravenously every 6 weeks on day 1, and @entity1487 ( @entity1487 ), 400 mg/m2 intravenously weekly--( @entity2098 )--or @entity1487 , 600 mg/m2 intravenously weekly ( @entity1487 ). One hundred twenty-six @entity1 are evaluable for response. Of 62 @entity1 treated with @entity2098 , one (2%) achieved complete remission, and three (5%) attained partial remission. Of 64 @entity1 treated with @entity1487 , two (3%) achieved complete remission, and eight (13%) attained partial remission. The median survival for @entity1 receiving @entity2098 was 9.5 months compared with 10.3 months for @entity1 receiving @entity1487 . The survival distributions for the two regimens were not significantly different, either unadjusted or adjusted for pretreatment characteristics. Performance status and lactic dehydrogenase (LDH) were both significantly associated with survival. @entity1 with liver metastases only and normal liver function tests had a median survival of 19.8 months and a 40% response rate. This randomized phase III trial did not show any therapeutic advantage for @entity2098 compared to @entity1487 therapy alone in advanced @entity14 . In addition, hematologic @entity137 was significantly greater with the combination ( @entity2098 ) regimen.

title: Combination chemotherapy ( @entity1487 , methyl-CCNU, @entity1138 ) versus XXXX alone for advanced previously untreated @entity14 . A phase III study of the Piedmont Oncology Association.

answer: @entity1487 :: (MESH:D005472,Chemical) :: ['5-fluorouracil']


abstract: UNASSIGNED: The aim of the present study was to determine the long-term outcomes of @entity75 following a rotational atherectomy (ROTA). In this retrospective study, @entity1 that had undergone a ROTA of the bifurcation coronary lesions in Juntendo University Hospital (Tokyo, Japan) were enrolled between January 2007 and December 2009, and received follow-up for a median duration of 48 months (range, 12-84 months). A total of 337 @entity1 were enrolled. Each @entity1 was treated with an average of 1.2  0.4 ROTA burrs (mean size, 2.9  0.3 mm). Baseline lesion length, reference diameter, @entity5562 ( @entity5562 ) and percentage of diameter stenosis (%DS) prior to the procedure were comparable between the @entity3918 and non- @entity3918 @entity1 . Furthermore, @entity5562 , %DS and @entity697 following the procedure were similar between the two groups. At follow-up, @entity3918 @entity1 exhibited a significantly decreased @entity5562 (1.97  0.92 vs. 2.26  0.73 mm; P=0.0038), increased %DS (27.9  21.3 vs. 20.2  13.3%; P=0.022) and late loss (0.70  0.45 vs. 0.42  0.36 mm; P=0.0047) compared with the non- @entity3918 @entity1 . Follow-up examinations (mean duration, 52.2  19.4 months) revealed that the @entity3918 @entity1 experienced significantly higher rates of @entity75 revascularization (TLR) [28 (15.7%) vs. 8 (5.0%); P=0.0011], @entity75 ( @entity75 ) restenosis [46 (25.8%) vs. 20 (12.6%); P=0.0019] and major adverse @entity299 (MACE) [36 (20.2%) vs. 19 (12.0%), P=0.039] compared with the non- @entity3918 @entity1 . Although the usage of ROTA and drug-eluting stent evidently improved long-term outcomes in @entity1 with @entity75 , @entity3918 remained an independent risk factor for TLR, @entity75 restenosis and MACE. Therefore, the management of @entity3918 in @entity75 treated with ROTA requires increased investigation in future clinical practice.

title: Long-term outcomes of rotational atherectomy in coronary XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute gain']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['bifurcation lesions', 'TL', 'target lesion']

entities_list: @entity5562 :: ('MESH:D015875', 'Disease') :: ['minimal lumen diameter', 'MLD']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

answer: @entity75 :: (MESH:D001927,Disease) :: ['bifurcation lesions']


abstract: BACKGROUND: The non-operative management of blunt @entity409 can be applied in almost 80% of @entity1 with this @entity130 , with the advantages of the need for fewer blood transfusions, less @entity1320 , and a better survival rate, than with the operative approach. However, @entity5572 , as a known complication of the non-operative management of blunt @entity409 , is discussed infrequently. Therefore, we herein review our experience and describe this complication in detail. MATERIALS AND METHODS: From 1995 to 2001, 674 @entity1 were admitted to our hospital due to blunt @entity99 . Among these @entity1 , 279 underwent laparotomy and the remaining 395 @entity1 were treated non-operatively. Twenty-two @entity1 were identified as having @entity5572 , with 16 of them belonging to the operative group, and six to the non-operative group. A retrospective review of these six @entity1 and their characteristics, as well as pathogenesis, diagnosis, and the management of the liver abscesses, was conducted. RESULTS: These six @entity1 were all male, with a median age of 19.5 years (range 3-24). The median injury severity score was 16.5 (range 9-25); three @entity1 sustained grade-3 @entity99 , and the other three were grade 4. The main diagnostic tool was abdominal computed tomography, and the abscesses took a median of 6 days (range 1-12) to form and be diagnosed. The abscesses were usually caused by infection from mixed organisms, and an abscess resulting from @entity8466 developed within 1 day after injury. These abscesses were treated with antibiotics and drainage, and the median length of hospital stay was 26 days (range 8-44), without mortality or long-term morbidity. CONCLUSION: @entity5572 as a complication of the non-operative management of blunt @entity99 is a rare entity, with an incidence of 1.5% (6/395). It is usually seen in severe @entity99 (grade 3 and above), but all our @entity1 were all treated successfully, with no mortality. However, prolonged hospitalization may be required in this @entity1 group.

title: @entity5572 after non-operative management of blunt XXXX .

entities_list: @entity5572 :: ('MESH:D008100', 'Disease') :: ['Liver abscess', 'liver abscess']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver trauma']

entities_list: @entity8466 :: ('MESH:D003015', 'Disease') :: ['Clostridium infection']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['intra-abdominal sepsis']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic injury', 'liver injury', 'hepatic trauma']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['type of injury']

answer: @entity99 :: (MESH:D056486,Disease) :: ['liver injury']


abstract: BACKGROUND: The non-operative management of blunt @entity409 can be applied in almost 80% of @entity1 with this @entity130 , with the advantages of the need for fewer blood transfusions, less @entity1320 , and a better survival rate, than with the operative approach. However, @entity5572 , as a known complication of the non-operative management of blunt @entity409 , is discussed infrequently. Therefore, we herein review our experience and describe this complication in detail. MATERIALS AND METHODS: From 1995 to 2001, 674 @entity1 were admitted to our hospital due to blunt @entity99 . Among these @entity1 , 279 underwent laparotomy and the remaining 395 @entity1 were treated non-operatively. Twenty-two @entity1 were identified as having @entity5572 , with 16 of them belonging to the operative group, and six to the non-operative group. A retrospective review of these six @entity1 and their characteristics, as well as pathogenesis, diagnosis, and the management of the liver abscesses, was conducted. RESULTS: These six @entity1 were all male, with a median age of 19.5 years (range 3-24). The median injury severity score was 16.5 (range 9-25); three @entity1 sustained grade-3 @entity99 , and the other three were grade 4. The main diagnostic tool was abdominal computed tomography, and the abscesses took a median of 6 days (range 1-12) to form and be diagnosed. The abscesses were usually caused by infection from mixed organisms, and an abscess resulting from @entity8466 developed within 1 day after injury. These abscesses were treated with antibiotics and drainage, and the median length of hospital stay was 26 days (range 8-44), without mortality or long-term morbidity. CONCLUSION: @entity5572 as a complication of the non-operative management of blunt @entity99 is a rare entity, with an incidence of 1.5% (6/395). It is usually seen in severe @entity99 (grade 3 and above), but all our @entity1 were all treated successfully, with no mortality. However, prolonged hospitalization may be required in this @entity1 group.

title: XXXX after non-operative management of blunt @entity99 .

answer: @entity5572 :: (MESH:D008100,Disease) :: ['Liver abscess']


abstract: UNASSIGNED: Whole-brain radiotherapy (WBRT) has been an important component of treatment for @entity149 ( @entity149 ), but delayed @entity2359 has been a matter of concern. We have employed partial-brain radiotherapy (PBRT) with wide margins for @entity149 @entity1 with a single lesion or a few lesions. In this study, we evaluated the treatment outcome in @entity149 @entity1 undergoing PBRT. Between 2003 and 2014, 24 @entity1 were treated with PBRT; 16 received high-dose- @entity1499 (MTX) -containing chemotherapy before PBRT. Conventional fractionation with a median dose of 54 Gy was used. For reference, 15 @entity1 undergoing MTX-based chemotherapy and WBRT were also analyzed. The 3-year overall survival rate was 60% for all 24 @entity1 undergoing PBRT and 68% for the 16 @entity1 undergoing MTX-based chemotherapy plus PBRT. The 3-year progression-free survival rate was 41% for all 24 @entity1 undergoing PBRT and 36% for the 16 @entity1 undergoing MTX-based chemotherapy. The in-field recurrence rate was 26% and the out-of-field recurrence rate was 15% at 3 years for all 24 @entity1 undergoing PBRT. The rates for in-field recurrence and the out-of-field recurrence were 27% and 21%, respectively, for the 16 @entity1 undergoing MTX-based chemotherapy. CNS-recurrence rates were similar in @entity1 undergoing MTX-based chemotherapy and PBRT to the rates in those undergoing MTX-based chemotherapy and WBRT. @entity149 developed in 3 of the 16 @entity1 undergoing MTX + PBRT and in 4 of 15 @entity1 undergoing MTX + WBRT (P = 0.68). PBRT seems to be a feasible treatment option for solitary @entity149 . Further investigations are warranted to evaluate the advantages of PBRT over WBRT.

title: Partial-brain radiotherapy for XXXX : multi-institutional experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['PCNSL', 'Neurocognitive dysfunction', 'primary central nervous system lymphoma']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity149 :: (MESH:D002493,Disease) :: ['primary central nervous system lymphoma']


abstract: OBJECTIVE: This study examined the impact of neoadjuvant chemotherapy and concurrent high-dose radiation therapy on survival in @entity1 with node-negative T3 and T4 @entity1149 . METHODS: A total of 110 consecutive @entity1 underwent surgical resection for invasive T3N0M0 (94 @entity1 ) and T4N0M0 (16 @entity1 ) @entity1149 between 1979 and 2008. Forty-seven @entity1 received neoadjuvant chemotherapy and concurrent high-dose (5940 cGy) radiation therapy before resection (Chemo-RT group). Sixty-three @entity1 underwent surgical resection without receiving induction chemoradiotherapy (Surg group), of whom 21 received neoadjuvant radiation, 19 received adjuvant radiation, 17 received surgery alone, 2 received adjuvant chemotherapy, 2 received adjuvant chemoradiotherapy, and 2 received brachytherapy. Survival of the Chemo-RT and Surg groups was compared using both crude and adjusted Cox proportional hazards models. RESULTS: The 5-year, 10-year, and median survivals were 61%, 50%, and 90 months, respectively, in the Chemo-RT group versus 22%, 14%, and 22 months, respectively, in the Surg group. Subjects in the Surg group had an increased risk of @entity204 (hazard ratio, 2.60; 95% confidence interval, 1.62-4.18; P  =  .0001) compared with the Chemo-RT group. After adjustment for potential confounding variables of age, sex, @entity5 size, @entity5 location, type of operation, and decade of care, subjects in the Surg group remained at increased risk of @entity204 (hazard ratio, 2.81; 95% confidence interval, 1.45-5.44, P  =  .002) compared with the Chemo-RT group. CONCLUSIONS: Aggressive treatment of node-negative invasive T3 and T4 NSCLC with induction chemoradiotherapy may significantly prolong survival. This approach should be evaluated in a prospective multicenter national trial.

title: Impact of neoadjuvant chemoradiotherapy followed by surgical resection on node-negative T3 and T4 XXXX .

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']


abstract: The objective of this study was to establish the necessary protocols and assess the efficacy of @entity4410 ( @entity4411 ) as an antimicrobial intervention on beef @entity291 hides. Experiments using CPC were conducted to determine (i) the methods of neutralization needed to obtain valid efficacy measurements, (ii) the effect of concentration and dwell time after treatment, (iii) the effect of CPC on hide and carcass microbial populations when @entity291 were treated at a feedlot and then transported to a processing facility for harvest, and (iv) the effectiveness of spray pressure and two-spray combinations of CPC and water to reduce hide microbial populations. Residual CPC in hide sponge samples prevented bacterial growth. Dey-Engley neutralization media at 7.8% and a centrifugation step were necessary to overcome this problem. All dwell times, ranging from 30 s to 4 h, after 1% CPC application to @entity291 hides resulted in aerobic plate counts and Enterobacteriaceae counts 1.5 log CFU/100 cm2 lower than controls. The most effective dose of CPC was 1%, which reduced aerobic plate counts and Enterobacteriaceae counts 2 and 1 log CFU/100 cm2, respectively. Low-pressure application of 1% CPC at the feedlot, transport to the processing facility, and harvest within 5 h of application resulted in no effect on @entity526 O157 prevalence on hides or preevisceration carcasses. Two high-pressure CPC washes lowered aerobic plate counts and Enterobacteriaceae counts by 4 log CFU/100 cm2, and two medium-pressure CPC washes were only slightly less effective. These results indicate that under the proper conditions, CPC may still be effective for reducing microbial populations on @entity291 hides. Further study is warranted to determine if this effect will result in reduction of hide-to-carcass contamination during processing.

title: Protocol for evaluating the efficacy of XXXX as a beef hide intervention.

entities_list: @entity4410 :: ('MESH:D002594', 'Chemical') :: ['cetylpyridinium chloride']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity4410 :: (MESH:D002594,Chemical) :: ['cetylpyridinium chloride']


abstract: Stationary-phase @entity5125 cells that were either pH dependent acid adapted or not acid adapted were heat challenged at 60 degrees C in a two-level full factorial design for three variables. The three variables and the levels consisted of tryptic soy broth (TSB) and sterile cell-free culture supernatant (sterile TSB), the presence and absence of 1% added @entity413 , and pH 4.8 and pH 7. Non-acid-adapted cells were most heat resistant when challenged in TSB (mean decimal reduction times at 60 degrees C: D60 = 1.16 min). In the absence of added @entity413 , non-acid-adapted cells had similar D60-values for inactivations at pH 4.8 and pH 7; however, the presence of @entity413 caused non-acid-adapted cells challenged at pH 4.8 to be more heat sensitive (D60 = 0.65 min) than those inactivated at pH 7 (D60 = 1.03 min), indicating an interaction between @entity413 and pH. Overall, the significantly decreased heat resistance of the acid-adapted cells was due to the presence of @entity413 (D60 = 0.78 min without @entity413 , D60 = 0.59 min with @entity413 ). Acid-adapted cells heat challenged in TSB had similar D60-values for inactivations at pH 4.8 and pH 7; however, acid-adapted cells in sterile TSB challenged at pH 4.8 (D60 = 0.52 min) had significantly lower heat resistance than did cells challenged at pH 7 (D60 = 0.76 min), indicating an interaction between the medium and pH. The @entity5125 survivor data were modeled to extract information on the frequency distribution of heat resistance within heat-challenged populations, and the frequency distribution characteristics of mean, mode, and variance were compared among treatment conditions. Significant differences in the frequency distribution data were compared with the D60-values. These data indicated that the presence and level of cross-protection is highly dependent on the physiological state of the cells and nutrient availability at the time of heat challenge. Such conditions should be considered to ensure that stressed pathogens in foods are destroyed or inactivated.

title: Changes in heat resistance resulting from pH and nutritional shifts of acid-adapted and non-acid-adapted XXXX Scott A.

entities_list: @entity5125 :: ('1639', 'Species') :: ['Listeria monocytogenes', 'L. monocytogenes']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity5125 :: (1639,Species) :: ['Listeria monocytogenes']


abstract: In view of the reported association of @entity978 ( @entity978 ) and ferritin, ferritin-bearing lymphocytes were followed during 2-year period in 79 @entity978 @entity1 . Indirect immunofluorescent method was used to evaluate the percentage of ferritin positive cells. In 22 untreated @entity1 a high percentage of ferritin-bearing circulating lymphocytes (mean value 37.3%) was found. In regard to the extent of the disease higher values were found in clinical stage III and IV (mean value 40.6%) as compared to the stage I and II (mean value 26.2%). Similarly, 17 @entity1 in relapse and with disease progression had mean values 41%. These proportions of cells were significantly lower in 44 @entity1 in complete remission with mean value of 8.7% (60 examinations). In 30 healthy controls the mean value was 1.4%. Repeatedly performed examinations of ferritin-bearing lymphocytes during the follow-up period in 17 @entity1 showed to be an important prognostic tool. A negative correlation of ferritin-bearing lymphocytes with E-rosette-forming cells was found. @entity68 content in peripheral blood lymphocytes was confirmed cytochemically after pre-incubation with antiferritin antibody. The results support the presumed role of ferritin in impaired cellular immunity in @entity978 and suggest diagnostic and prognostic value of the examination of ferritin-bearing lymphocytes in @entity978 .

title: Ferritin-bearing lymphocytes in XXXX .

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease", 'HD']

answer: @entity978 :: (MESH:D006689,Disease) :: ['Hodgkin's disease']


abstract: OBJECTIVE: The objective was to analyse relationships between inspiratory and expiratory static and dynamic elastic pressure-volume (P(el)/V) curves in healthy @entity1707 . DESIGN: The modulated low flow method was developed to allow studies also of the expiratory P(el)/V curves. Static P(el)/V (P(el,st)/V) and dynamic P(el)/V (P(el,dyn)/V) loops were studied in healthy @entity1707 . SETTING: Animal research laboratory in a university hospital. MATERIAL: Ten healthy anaesthetised and paralysed @entity1707 . INTERVENTIONS AND MEASUREMENTS: A computer controlled a Servo Ventilator 900C with respect to respiratory rate, inspiratory flow and expiratory pressure to achieve a sinusoidal modulation of inspiration and expiration for determination of P(el,dyn)/V loops from zero end-expiratory pressure (ZEEP) and from a positive end-expiratory pressure (PEEP) of 6 cm @entity2507 to 20, 35 and 50 cm @entity2507 . The same system was used for studies of P(el,st)/V loops with the flow-interruption method from ZEEP and @entity9239 to 35 cm @entity2507 . Recordings were analysed with an iterative technique. RESULTS: The feasibility of automated determination of P(el,dyn)/V loops was demonstrated. Differences between P(el,dyn)/V and P(el,st)/V loops were explained by viscoelastic behaviour. P(el,st)/V loops recorded from PEEP to 35 cm @entity2507 showed no significant hysteresis, indicating a non-significant surface tension hysteresis. P(el,dyn)/V loops from PEEP and both P(el,st)/V and P(el,dyn)/V loops from ZEEP to 35 cm @entity2507 showed hysteresis. This indicates that lung collapse/re-expansion caused P(el)/V loop hysteresis which, in P(el,dyn)/V loops, was augmented by viscoelastic behaviour. CONCLUSIONS: Viscoelasticity influences P(el,dyn)/V curves. Hysteresis caused by surface tension merits re-evaluation. @entity891 and re-expansion may be indicated by hysteresis of P(el)/V loops.

title: Dynamic elastic pressure-volume loops in healthy XXXX recorded with inspiratory and expiratory sinusoidal flow modulation. Relationship to static pressure-volume loops.

entities_list: @entity891 :: ('MESH:D001261', 'Disease') :: ['Lung collapse']

answer: @entity1707 :: (9823,Species) :: ['pigs']


abstract: In this article two @entity1 are reported with recurrent upper airways and @entity281 . Laboratory investigation showed a persistent @entity1398 . The @entity236 showed a normal cellularity of the erythroid series and the megakaryocytes. The myeloid series were normal with a decreased number of mature segmented neutrophils. In these patients the serum levels of immunoglobulins were within normal range and antibodies against the white cells could not be demonstrated. By the age of 2-3 years the recurrence of @entity281 had decreased and @entity281 of importance have not been reported since. By that age the peripheral white count was not abnormal. This combination of signs and symptoms is known as 'chronic @entity1398 '. The etiology is obscure. Our investigation in one case (by that time recovered) showed a diminished growth of the myeloid series of donor bone marrow in the presence of patient's serum. This suggests a plasma-factor responsible for the maturation of the myeloid series. This finding has not yet been reported in the literature.

title: [Chronic XXXX possibly caused by a plasma factor].

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections', 'ENT-infections']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['benign neutropenia', 'neutropenia']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow aspirations']

answer: @entity1398 :: (MESH:D009503,Disease) :: ['benign neutropenia']


abstract: The aim of this study was to determine the prevalence of signs and symptoms of @entity2956 in @entity1 with @entity1005 ( @entity1005 ) occurring as a consequence of exposure to war stress. The examined group consisted of 100 male subjects, aged from 25 to 50 years, who had taken part in the War in Croatia, and in whom @entity1005 had previously been diagnosed. The control group comprised 100 subjects, without @entity1005 , of the same sex and age group, who had not taken part in the War. A functional evaluation of the stomatognathic system was performed using the Helkimo Anamnestic and Clinical Dysfunction Index. Eighty-two per cent of the group with @entity1005 had at least one symptom, and 98% at least one sign of @entity409 . Eight per cent reported mild symptoms and 74% severe symptoms. Twenty-eight per cent showed mild clinical signs, 22% had signs of moderate, and 48% of severe @entity409 . Twenty-four per cent of the control group of subjects had at least one symptom, and 52% at least one clinical sign of @entity409 . Twenty-two per cent reported mild and 2% severe symptoms. Mild clinical signs of @entity409 were found in 50% of subjects in the control group, moderate in 2% and none exhibited severe clinical signs. It is concluded that correlation exists between war stress and @entity2956 .

title: The influence of war stress on the prevalence of signs and symptoms of XXXX .

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['dysfunction']

entities_list: @entity2956 :: ('MESH:D013705', 'Disease') :: ['temporomandibular disorders']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['post-traumatic stress disorder', 'PTSD']

answer: @entity2956 :: (MESH:D013705,Disease) :: ['temporomandibular disorders']


abstract: OBJECTIVE: The objective of this study was to determine the relationship between drug-related problems (DRPs) and health-related quality-of-life (HRQoL) in ambulatory, community-dwelling @entity1 with @entity85 . METHODS: A 12-month, prospective, observational study was conducted in 12 independent community pharmacies in eastern Iowa. Ambulatory @entity1 with self-reported diagnoses of @entity571 , @entity309 , or @entity1643 were invited to participate. During quarterly visits to the pharmacy, @entity1 used touch-screen computers to fill out the Short Form-36 (SF-36) general health survey. Using the results of these point-of-service health status assessments, community pharmacists interviewed @entity1 to assess for DRPs. To examine the influences of different DRP characteristics on HRQoL and controlling for potential confounders, both univariate and multivariate analyses were performed using the change in physical component summary (PCS) score and @entity1032 ( @entity1032 ) score of the SF-36 from baseline to 12 months as the dependent variables. In each regression, the independent variables were those significant variables from the univariate analyses, as well as the types of DRPs and their outcomes. RESULTS: A total of 461 @entity1 were enrolled in the study. Through 12 months, 926 cumulative DRPs were identified. Overall regression models were significant for the PCS and @entity1032 scores, respectively. Two types of DRPs showed significant negative associations with change in PCS: wrong drug and needs additional drug therapy. One type of DRP showed significant negative association with change in @entity1032 : needs additional drug therapy. Resolution or improvement in DRPs showed a significant positive correlation with change in @entity1032 but not PCS. CONCLUSIONS: Two DRPs, needs additional drug therapy and wrong drug, are associated with reduced self-reported physical health in @entity625 and @entity1643 , while the DRP needs additional drug therapy is also associated with reduced self-reported mental health. Resolution of DRPs is associated with improvement in mental health in this cohort.

title: Drug-related problems and quality of life in @entity625 and XXXX sufferers.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental component summary', 'MCS']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal disorders']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['low back pain']


abstract: OBJECTIVE: The objective of this study was to determine the relationship between drug-related problems (DRPs) and health-related quality-of-life (HRQoL) in ambulatory, community-dwelling @entity1 with @entity85 . METHODS: A 12-month, prospective, observational study was conducted in 12 independent community pharmacies in eastern Iowa. Ambulatory @entity1 with self-reported diagnoses of @entity571 , @entity309 , or @entity1643 were invited to participate. During quarterly visits to the pharmacy, @entity1 used touch-screen computers to fill out the Short Form-36 (SF-36) general health survey. Using the results of these point-of-service health status assessments, community pharmacists interviewed @entity1 to assess for DRPs. To examine the influences of different DRP characteristics on HRQoL and controlling for potential confounders, both univariate and multivariate analyses were performed using the change in physical component summary (PCS) score and @entity1032 ( @entity1032 ) score of the SF-36 from baseline to 12 months as the dependent variables. In each regression, the independent variables were those significant variables from the univariate analyses, as well as the types of DRPs and their outcomes. RESULTS: A total of 461 @entity1 were enrolled in the study. Through 12 months, 926 cumulative DRPs were identified. Overall regression models were significant for the PCS and @entity1032 scores, respectively. Two types of DRPs showed significant negative associations with change in PCS: wrong drug and needs additional drug therapy. One type of DRP showed significant negative association with change in @entity1032 : needs additional drug therapy. Resolution or improvement in DRPs showed a significant positive correlation with change in @entity1032 but not PCS. CONCLUSIONS: Two DRPs, needs additional drug therapy and wrong drug, are associated with reduced self-reported physical health in @entity625 and @entity1643 , while the DRP needs additional drug therapy is also associated with reduced self-reported mental health. Resolution of DRPs is associated with improvement in mental health in this cohort.

title: Drug-related problems and quality of life in XXXX and @entity1643 sufferers.

answer: @entity625 :: (MESH:D001168,Disease) :: ['arthritis']


abstract: BACKGROUND AND PURPOSE: The best strategy for treatment of @entity510 due to @entity1756 is obliteration of the @entity439 as soon as possible. Early surgery is desirable if the @entity1 does not develop severe @entity2553 or is clinically stable. However, if the @entity1 has already developed severe @entity2553 on admission, surgery may carry the risk of increasing the severity. We evaluated the safety and effectiveness of combined Guglielmi detachable coil (GDC) @entity887 and angioplasty in a single session for the treatment of @entity1756 associated with symptomatic @entity2553 . METHODS: From January 1992 to January 2001, 12 consecutive @entity1 with @entity1756 associated with symptomatic @entity2553 were treated. @entity1 were classified as Hunt and Hess grade 2 (n = 1), 3 (n = 6), 4 (n = 4), or 5 (n = 1) and Fisher CT group 2 (n = 1), 3 (n = 10), or 4 (n = 1). They underwent GDC @entity439 and balloon angioplasty (n = 6), intraarterial papaverine infusion (n = 2), or both (n = 4) in a single session. In nine @entity1 , @entity439 coil occlusion was performed first. RESULTS: @entity432 was achieved in eight @entity1 , a small neck remnant persisted in three, and @entity887 was incomplete in one @entity1 . In all @entity1 , angiographic improvement of @entity2553 was obtained. In one @entity1 , a @entity1031 occurred and was treated with urokinase. Clinical outcomes at discharge were good recovery in six, moderate disability in two, severe disability in three, or @entity204 in one. CONCLUSION: Endovascular treatment can be the first therapeutic option for @entity1756 associated with severe @entity2553 on admission. It offers some advantages over surgery in this setting, but these are balanced by the risk of @entity1031 .

title: Combined endovascular treatment for both intracranial aneurysm and symptomatic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolization']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm', 'aneurysm occlusion']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism', 'thromboembolic complication']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['Complete GDC occlusion']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['vasospasm']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured aneurysms', 'ruptured cerebral aneurysm']

answer: @entity2553 :: (MESH:D020301,Disease) :: ['vasospasm']


abstract: BACKGROUND: @entity358 is occasionally detected on routine imaging studies in healthy hosts with no or mild symptoms. Isolated @entity358 may be observed without specific therapy in asymptomatic immunocompetent hosts. However, considering that dissemination from a @entity358 can occur in @entity1 with no immunologic defects, treatment of asymptomatic @entity358 in immunocompetent hosts remains controversial. The aim of this study was to determine the role of @entity2380 therapy in the management of isolated @entity358 in asymptomatic healthy hosts. METHODS: We retrospectively analyzed the medical records and radiographic findings of 10 healthy subjects with isolated @entity358 diagnosed incidentally and treated with oral @entity2380 . RESULTS: All @entity1 had no respiratory or constitutional symptoms. The most common radiological findings were pulmonary nodules, and the number of nodules in each @entity1 was from 1 to 9. After histological confirmation, all @entity1 were treated with oral @entity2380 at a dosage of 400 mg per day for a median period of 6.4 months. No @entity1 developed an adverse reaction to @entity2380 . The mean interval between the initiation of antifungal therapy and final radiological response was 8.3 months. Seven of the 10 @entity1 showed complete resolution, and the other 3 @entity1 were assessed as having partial resolution. During the average follow-up period of 11.9 months, all @entity1 showed a favourable outcome with no relapse. The overall cure rate was 70%. CONCLUSION: These results suggest that @entity2380 may be an attractive therapeutic option for asymptomatic @entity358 in immunocompetent hosts.

title: Treatment of asymptomatic XXXX in immunocompetent hosts with oral @entity2380 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary cryptococcosis', 'pulmonary infection', 'Pulmonary cryptococcosis']

entities_list: @entity2380 :: ('MESH:D015725', 'Chemical') :: ['fluconazole']

answer: @entity358 :: (MESH:D008171,Disease) :: ['pulmonary cryptococcosis']


abstract: BACKGROUND: @entity358 is occasionally detected on routine imaging studies in healthy hosts with no or mild symptoms. Isolated @entity358 may be observed without specific therapy in asymptomatic immunocompetent hosts. However, considering that dissemination from a @entity358 can occur in @entity1 with no immunologic defects, treatment of asymptomatic @entity358 in immunocompetent hosts remains controversial. The aim of this study was to determine the role of @entity2380 therapy in the management of isolated @entity358 in asymptomatic healthy hosts. METHODS: We retrospectively analyzed the medical records and radiographic findings of 10 healthy subjects with isolated @entity358 diagnosed incidentally and treated with oral @entity2380 . RESULTS: All @entity1 had no respiratory or constitutional symptoms. The most common radiological findings were pulmonary nodules, and the number of nodules in each @entity1 was from 1 to 9. After histological confirmation, all @entity1 were treated with oral @entity2380 at a dosage of 400 mg per day for a median period of 6.4 months. No @entity1 developed an adverse reaction to @entity2380 . The mean interval between the initiation of antifungal therapy and final radiological response was 8.3 months. Seven of the 10 @entity1 showed complete resolution, and the other 3 @entity1 were assessed as having partial resolution. During the average follow-up period of 11.9 months, all @entity1 showed a favourable outcome with no relapse. The overall cure rate was 70%. CONCLUSION: These results suggest that @entity2380 may be an attractive therapeutic option for asymptomatic @entity358 in immunocompetent hosts.

title: Treatment of asymptomatic @entity358 in immunocompetent hosts with oral XXXX .

answer: @entity2380 :: (MESH:D015725,Chemical) :: ['fluconazole']


abstract: OBJECTIVES: To report the outcomes of two-stage repair for @entity2650 using a buccal mucosa graft as a tube. METHODS: A total of 57 adult @entity1 who underwent surgery for severe @entity5331 at our institution from January 2002 to March 2010 were included in this analysis. The urethroplasty procedure included penile urethra reconstruction with the buccal mucosa graft used as a tube in the first stage, @entity254 of the unobstructed urethra in the second stage and a scrotal fascio-cutaneous flap transferred to resurface the reconstructed urethra for waterproofing. RESULTS: No complications occurred after the first stage, whereas @entity86 occurred in six cases and @entity39 occurred in two cases after the second stage. All eight of these @entity1 had the complication of @entity292 , which healed after 2-4 weeks by cleaning and changing dressings in six @entity1 . Twelve @entity1 complained of straining at voiding in the early postoperative period. However, nine of these @entity1 had an obvious increase in maximum flow rate without any intervention 3 months after the operation. Follow up ranged from 6 to 62 months (mean 28 months) in 46 @entity1 . Most of the @entity1 presented terminal meatus, no chordee, no urethral stricture and normal voiding. The majority of @entity1 achieved excellent cosmetic and functional results. CONCLUSIONS: A buccal mucosa graft as a tube is a reliable and durable method of two-stage repair for severe and complicated @entity2650 in adults. The use of scrotal flaps seems to contribute to a good vascularized waterproof cover.

title: Two-stage repair with buccal mucosa for severe and complicated XXXX in adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5331 :: ('MESH:D014522', 'Disease') :: ['urethral defect']

entities_list: @entity2650 :: ('MESH:D007021', 'Disease') :: ['adult hypospadias', 'hypospadias']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['distal necrosis of the scrotal flap']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['urethrocutaneous fistula']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative infections']

answer: @entity2650 :: (MESH:D007021,Disease) :: ['hypospadias']


abstract: @entity2132 ( @entity2132 ) is a major cause of morbidity and mortality following allogeneic bone marrow transplantation (BMT). We studied 159 @entity1 with @entity2132 longitudinally to characterize the natural history of @entity2132 and identify reliable predictors of response and long-term mortality. Rates of response to treatment were 61%, 53%, and 50% at 6 months, 1 year, and 2 years, respectively. A high incidence of @entity281 (7 of 1,000 @entity1 -days at 0 to 6 months, 2.5 of 1,000 @entity1 -days at 6 months to 1 year, and 0.6 of 1,000 @entity1 -days at 1 to 2 years) was observed. After a median follow-up of 8.4 years, an overall survival rate of 40% was observed. The overall survival rate was 63% (95% confidence interval [CI], 56%-71%) at 1 year, 51% (95% CI, 43%-59%) at 2 years, and 39% (95% CI, 31%-47%) at 10 years. In multivariate analysis, age older than 20 years (RR = 1.5; 95% CI, 0.9%-2.5%; P =.09), progressive onset of @entity2132 (RR = 1.6; 95% CI, 1.0%-2.4%; P =.04), platelet count of <100,000/ microL (RR = 2.1; 95% CI, 1.3%-3.4%; P =.001), and GI involvement (RR = 1.5; 95% CI, 1.0%-2.4%; P =.05) were associated with increased mortality. Among @entity1 surviving more than 6 months, no response (RR = 4.5; 95% CI, 1.9%-10.5%; P =.0006) and partial response (RR = 2.5; 95% CI, 1.1%-6.1%; P =.04) to treatment at 6 months also were significant predictors of mortality. The prevalence of active @entity2132 was 33% at 2 years. However, the cumulative incidence of successful discontinuation of therapy was only 13% at 2 years. Among @entity1 with clinical resolution of @entity2132 , only 18% were off immunosuppressive therapy by 2 years, and 89% by 4 years. Despite high initial response rates, a large majority of @entity1 had active disease requiring prolonged immunosuppression. This requires improved infection prevention for a longer time. Recognition of a high-risk group should facilitate assignment of more intensified regimens. Better treatment regimens need to be identified to improve survival and limit @entity137 of prolonged immunosuppression.

title: XXXX : a prospective cohort study.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['Chronic graft-versus-host disease', 'CGVHD']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

answer: @entity2132 :: (MESH:D006086,Disease) :: ['Chronic graft-versus-host disease']


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity631 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity9367 (Trip). The present study was to investigate the effect of Trip on @entity8 in a model of @entity1695 ( @entity1695 ). METHODS: @entity1695 or sham-operated @entity35 were randomly assigned to receive @entity618 ( @entity2098 ), Trip or vehicle and were killed on days 7 and 14 after @entity1695 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity657 ( @entity657 ) and osteopontin. Interstitial collagen deposition and amounts of @entity1810 ( @entity1810 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity1810 , @entity2528 ( @entity2528 ), @entity657 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity657 and osteopontin, interstitial collagen deposition and amounts of @entity1810 were significantly reduced by @entity2098 or Trip. @entity2098 or Trip significantly reduced the mRNA expression of @entity1810 , @entity2528 , @entity657 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity82 in a @entity35 @entity1695 model and the effect of Trip on @entity8 was similar to that of @entity2098 . Trip may be useful as a potential candidate in the treatment of @entity8 .

title: @entity9367 attenuates XXXX in @entity35 with @entity1695 .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal fibrosis', 'renal interstitial fibrosis']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity1695 :: ('MESH:D014517', 'Disease') :: ['UUO', 'unilateral ureteral obstruction']

entities_list: @entity657 :: ('24770(Tax:10116)', 'Gene') :: ['monocyte chemoattractant protein-1', 'MCP-1']

entities_list: @entity9367 :: ('MESH:C001899', 'Chemical') :: ['triptolide']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity1810 :: ('59086(Tax:10116)', 'Gene') :: ['transforming growth factor-b1', 'TGF-b1']

entities_list: @entity2528 :: ('64032(Tax:10116)', 'Gene') :: ['CTGF', 'connective tissue growth factor']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

answer: @entity8 :: (MESH:D007674,Disease) :: ['renal interstitial fibrosis']


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity631 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity9367 (Trip). The present study was to investigate the effect of Trip on @entity8 in a model of @entity1695 ( @entity1695 ). METHODS: @entity1695 or sham-operated @entity35 were randomly assigned to receive @entity618 ( @entity2098 ), Trip or vehicle and were killed on days 7 and 14 after @entity1695 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity657 ( @entity657 ) and osteopontin. Interstitial collagen deposition and amounts of @entity1810 ( @entity1810 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity1810 , @entity2528 ( @entity2528 ), @entity657 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity657 and osteopontin, interstitial collagen deposition and amounts of @entity1810 were significantly reduced by @entity2098 or Trip. @entity2098 or Trip significantly reduced the mRNA expression of @entity1810 , @entity2528 , @entity657 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity82 in a @entity35 @entity1695 model and the effect of Trip on @entity8 was similar to that of @entity2098 . Trip may be useful as a potential candidate in the treatment of @entity8 .

title: XXXX attenuates @entity8 in @entity35 with @entity1695 .

answer: @entity9367 :: (MESH:C001899,Chemical) :: ['Triptolide']


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity631 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity9367 (Trip). The present study was to investigate the effect of Trip on @entity8 in a model of @entity1695 ( @entity1695 ). METHODS: @entity1695 or sham-operated @entity35 were randomly assigned to receive @entity618 ( @entity2098 ), Trip or vehicle and were killed on days 7 and 14 after @entity1695 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity657 ( @entity657 ) and osteopontin. Interstitial collagen deposition and amounts of @entity1810 ( @entity1810 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity1810 , @entity2528 ( @entity2528 ), @entity657 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity657 and osteopontin, interstitial collagen deposition and amounts of @entity1810 were significantly reduced by @entity2098 or Trip. @entity2098 or Trip significantly reduced the mRNA expression of @entity1810 , @entity2528 , @entity657 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity82 in a @entity35 @entity1695 model and the effect of Trip on @entity8 was similar to that of @entity2098 . Trip may be useful as a potential candidate in the treatment of @entity8 .

title: @entity9367 attenuates @entity8 in @entity35 with XXXX .

answer: @entity1695 :: (MESH:D014517,Disease) :: ['unilateral ureteral obstruction']


abstract: AIM: Extracts of Tripterygium wilfordii Hook F. have been used to treat @entity631 for more than 30 years in China. Most of the anti-inflammatory and immunosuppressive activities of these extracts can be attributed to @entity9367 (Trip). The present study was to investigate the effect of Trip on @entity8 in a model of @entity1695 ( @entity1695 ). METHODS: @entity1695 or sham-operated @entity35 were randomly assigned to receive @entity618 ( @entity2098 ), Trip or vehicle and were killed on days 7 and 14 after @entity1695 or sham operation. Kidney specimens were fixed for immunohistochemistry for myofibroblasts (a-smooth muscle actin, a-SMA), macrophages (ED-1), @entity657 ( @entity657 ) and osteopontin. Interstitial collagen deposition and amounts of @entity1810 ( @entity1810 ) were determined by Sirius red staining and enzyme-linked immunosorbent assay, respectively. The mRNA expression of @entity1810 , @entity2528 ( @entity2528 ), @entity657 and osteopontin were measured by real-time polymerase chain reaction analysis. RESULTS: The scores for the density of a-SMA- and ED-1-positive cells, the staining of @entity657 and osteopontin, interstitial collagen deposition and amounts of @entity1810 were significantly reduced by @entity2098 or Trip. @entity2098 or Trip significantly reduced the mRNA expression of @entity1810 , @entity2528 , @entity657 and osteopontin. CONCLUSION: Trip significantly attenuated tubulointerstitial @entity82 in a @entity35 @entity1695 model and the effect of Trip on @entity8 was similar to that of @entity2098 . Trip may be useful as a potential candidate in the treatment of @entity8 .

title: @entity9367 attenuates @entity8 in XXXX with @entity1695 .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: Surgical stress elicits a characteristic response involving induction of synthesis and release of acute-phase proteins such as @entity1851 ( @entity1851 ). To objectively evaluate the surgical stress in @entity1 with asymptomatic @entity438 , serum levels of @entity1851 after direct clipping via the pterional approach were measured. METHODS: 42 @entity1 who experienced an uneventful postoperative course, were evaluated according to age (less or more than 65 years old [adult or elderly]), aneurysmal location (middle cerebral artery territory [MC], anterior communicating artery [Acom] or internal carotid artery territory [ @entity2337 ]) and intraoperative @entity130 (positive or negative). We defined intraoperative @entity130 as intentional vein cutting, perforator vessel injury or suction of the gyrus rectus. All @entity1 received standardized general anesthesia and were treated after the operations according to our standard protocols. Serum levels of @entity1851 on postoperative day 2 were compared in each category. RESULTS: Serum levels of @entity1851 showed no significant difference between the adult group and the elderly group, but were greater in Acom @entity1 than in MC and @entity2337 @entity1 (p < 0.01, p < 0.05). As to intraoperative @entity130 , the positive group (almost all were intentional vein cutting) showed greater @entity1851 levels than the negative group in MC and @entity2337 @entity1 (p < 0.05). Operation time and volume of @entity190 were almost the same in each category. CONCLUSION: Our study shows that as far as serum levels of @entity1851 are concerned, Acom location and vein cutting are the main factors of surgical stress in cases of @entity439 .

title: [Surgical stress in @entity1 with asymptomatic XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['unruptured aneurysms']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumas', 'trauma']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['unruptured intracranial aneurysms']

answer: @entity438 :: (MESH:D002532,Disease) :: ['unruptured intracranial aneurysms']


abstract: BACKGROUND: Surgical stress elicits a characteristic response involving induction of synthesis and release of acute-phase proteins such as @entity1851 ( @entity1851 ). To objectively evaluate the surgical stress in @entity1 with asymptomatic @entity438 , serum levels of @entity1851 after direct clipping via the pterional approach were measured. METHODS: 42 @entity1 who experienced an uneventful postoperative course, were evaluated according to age (less or more than 65 years old [adult or elderly]), aneurysmal location (middle cerebral artery territory [MC], anterior communicating artery [Acom] or internal carotid artery territory [ @entity2337 ]) and intraoperative @entity130 (positive or negative). We defined intraoperative @entity130 as intentional vein cutting, perforator vessel injury or suction of the gyrus rectus. All @entity1 received standardized general anesthesia and were treated after the operations according to our standard protocols. Serum levels of @entity1851 on postoperative day 2 were compared in each category. RESULTS: Serum levels of @entity1851 showed no significant difference between the adult group and the elderly group, but were greater in Acom @entity1 than in MC and @entity2337 @entity1 (p < 0.01, p < 0.05). As to intraoperative @entity130 , the positive group (almost all were intentional vein cutting) showed greater @entity1851 levels than the negative group in MC and @entity2337 @entity1 (p < 0.05). Operation time and volume of @entity190 were almost the same in each category. CONCLUSION: Our study shows that as far as serum levels of @entity1851 are concerned, Acom location and vein cutting are the main factors of surgical stress in cases of @entity439 .

title: [Surgical stress in XXXX with asymptomatic @entity438 ].

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Malignant perivascular epitheliod cell @entity5 ( @entity1824 ) is a very rare entity composed of distinctive perivascular epitheliod cells with variable immunoreactivity for melanocytic and muscle markers. At present this @entity5 does not have a known normal cellular counterpart and the natural history is often unpredictable. Up to now, few cases of @entity1824 have been described and treatment modalities are still controversial, particularly in advanced conditions. CASE PRESENTATION: We handled the case of a 42-year-old @entity1 with unresectable @entity1824 of the abdomen. A 7 cm hepatic hypodense lesion between segment V and @entity797 of the liver and diffuse intraperitoneal nodules of 0,3-3,5 cm along the right subcapsular hepatic region, were documented by a CT scan. Radiological images showed abnormal lymph nodes of the right internal mammary chain and anterior @entity6830 . The @entity1 underwent an explorative laparotomy for uncontrolled @entity548 without a well-defined preoperative @entity5 diagnosis. At surgery, multiple lobulated nodules containing hemorrhagic fluid on the liver surface, peritoneum and omentum were confirmed. The procedure had a palliative intent and consisted of hemostasis, @entity1410 evacuation and omentectomy. The diagnosis of @entity1824 was made after surgery on the basis of morphological and immunohistochemical criteria. Radiological and intra operative findings suggest that the mass has an hepatic origin with diffuse involvement of hepatic capsule and suspensory ligaments. The @entity1 received medical support care with blood and plasma transfusions. In our experience, @entity1824 was clinically malignant, leading to a fatal outcome 25 days after hospital admission of @entity1 . CONCLUSIONS: Here we report and discuss the peculiar clinical, radiological and morphological presentation of unresectable @entity1824 . Although in the majority of the reported series, @entity1824 show a more better prognosis, our case presents with a particular @entity146 biological behaviour. The importance of a correct preoperative diagnosis, the need for more effective targeted therapies based on @entity5 molecular knowledge and evidence-based clinical studies are emphasized together with a revision of the concerning scientific literature.

title: XXXX : a case report with emphasis on clinical and morphological criteria.

entities_list: @entity1824 :: ('MESH:D054973', 'Disease') :: ['PEComas', 'PEComa']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intraabdominal hemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas']

entities_list: @entity6830 :: ('MESH:D008479', 'Disease') :: ['mediastinum']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Malignant PEComa']


abstract: The life expectancy of @entity1 with @entity1555 ( @entity1555 ) has increased. A cross-sectional study of @entity1555 @entity1 showed that 54 % of 13-year-old @entity1 are @entity28 and that 54 % of 18-year-old @entity1 are underweight. We aimed to describe the natural evolution of weight status in @entity1555 . This retrospective multi-centre audit collected body-weight measurements for seventy @entity1555 @entity1 born before 1992. The body-weight:age ratio (W:A) was used to evaluate weight status in reference to the Griffiths and Edwards chart. At the age of 13 years, 73 % were @entity28 and 4 % were underweight. At maximal follow-up (age 15-26 years, mean 18  3 (sd 2  3) years), 47 % were @entity28 and 34 % were underweight. Obesity at the age of 13 years was associated with @entity28 , whereas normal weight status and underweight in 13-year-old @entity1 predicted later underweight. A W:A >=  151 % in 13-year-old @entity1 predicted @entity28 , and a W:A  <= 126  5 % predicted later underweight. Our audit provides the first longitudinal information about the spontaneous outcome of weight status in @entity1555 . @entity1 (13 years old) with a W:A >=  151 % were more likely to become @entity28 in late adolescence, but @entity28 prevented later underweight. These data suggest that mild @entity28 in 13-year-old @entity1555 @entity1 (W:A between 120 and 150 %) should not be discouraged because it prevents later underweight.

title: Natural evolution of weight status in XXXX : a retrospective audit.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ['Duchenne muscular dystrophy', 'DMD']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['later obesity', 'obese', 'obesity']

answer: @entity1555 :: (MESH:D020388,Disease) :: ['Duchenne muscular dystrophy']


abstract: BACKGROUND: Little is known about @entity1 ' views on taking selective @entity750 -reuptake inhibitors (SSRIs) and their decision-making processes regarding either continuation or discontinuation within a few months of initiating therapy. OBJECTIVE: To explore the experiences and beliefs of SSRI users in relation to initiation and execution of treatment, with the intention to identify patterns leading to discontinuation or continuation of treatment. METHODS: Semistructured qualitative interview study. Eighteen @entity1 , older than 18 years, were interviewed 3 months after starting SSRI treatment prescribed by a general practitioner (GP), 9 of whom had discontinued (discontinuers) and 9 of whom continued treatment (continuers). RESULTS: Two main patterns lead to either discontinuation or continuation of use. Continuers were satisfied with the GP's role during initiation and execution of SSRI treatment and fully trusted their decision. Continuers' attitudes toward treatment were predominantly positive; they seemed to have little doubt about the necessity of using an SSRI and hardly considered discontinuing for fear of relapse. Discontinuers, on the other hand, seemed to be less involved in decision making and often appeared to have little confidence in their GPs. Most discontinuers felt that they lacked knowledge, and their attitude toward taking SSRIs was rather negative. Discontinuers often were unconvinced about the necessity of using an SSRI and appeared to have a strong desire to discontinue treatment. CONCLUSION: Lack of shared decision making between @entity1 and GP, limited counseling during treatment, lack of knowledge, and @entity1 ' negative attitudes toward SSRI use and the disease itself, hampered the acceptance of the SSRI and brought on the decisional conflict to discontinue treatment. Health care professionals could be more supportive during the initial months of SSRI treatment by eliciting @entity1 ' considerations for continuing or discontinuing treatment.

title: The decision to continue or discontinue treatment: experiences and beliefs of users of selective XXXX -reuptake inhibitors in the initial months--a qualitative study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

answer: @entity750 :: (MESH:D012701,Chemical) :: ['serotonin']


abstract: OBJECTIVE: To examine the outcome of assisted reproduction techniques (ART) using cryopreserved semen from @entity1 with @entity5 . DESIGN: Prospective. SETTING: Therapeutic semen banking program at a tertiary healthcare center. @entity1 (S): Twenty-nine @entity1 with @entity5 who cryopreserved their sperm before treatment at our facility from 1982 to 2001 and withdrew their samples for assisted reproduction (IUI, IVF, or intracytoplasmic sperm injection [ICSI]). INTERVENTION(S): Sperm bank records were used to identify the @entity1 . Information on fertility potential indices was obtained from medical records and through interviews. Of the 29 @entity1 , 9 had @entity5 , 12 had @entity978 , and 8 had other types of @entity5 . MAIN OUTCOME MEASURE(S): Pregnancy and live births. RESULT(S): A total of 87 ART cycles (42 IUI, 26 IVF, and 19 ICSI) was performed. Of those cycles, 18.3% resulted in pregnancy (7% IUI, 23% IVF, and 37% ICSI), and 75% of the pregnancies resulted in a live birth (100% IUI, 83% IVF, and 57% ICSI). There was no significant difference in the outcomes when the results were stratified by type of ART and @entity5 . None of the 11 @entity1 who were born had @entity154 . CONCLUSION(S): Our findings emphasize the need for physicians to discuss the issue of semen cryopreservation with all @entity1 of reproductive age who have @entity5 before antineoplastic therapy is started.

title: Fertility after XXXX : a prospective review of assisted reproductive outcome with banked semen specimens.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'infants', 'PATIENT', 'men']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['congenital anomalies']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['testicular cancer', 'cancer', 'malignancy']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND: Most dietary pattern analyses in southern Europe have relied on a priori food approaches using Mediterranean-style diet indexes. These methods may not reflect the current population's food consumption. OBJECTIVE: To assess the association of a posteriori dietary patterns with @entity583 ( @entity583 ) and cardiovascular risk markers in the general adult population of Porto, Portugal. DESIGN: A population-based case-control study was conducted. Information was collected by trained interviewers. Diet was assessed with a validated 82-item food frequency questionnaire. @entity1 /SETTING: Cases were @entity1 consecutively hospitalized for an incident non-fatal @entity583 (n=820), and controls were individuals free of previous @entity583 selected from the hospitals' catchment area (n=2,196). STATISTICAL ANALYSES: Dietary patterns, representing mutually exclusive clusters of individuals, were identified by multivariate finite mixture models among controls. Odds ratios (OR) and their 95% confidence intervals (CIs) were obtained from unconditional logistic regression, with adjustment for main confounders. RESULTS: In comparison to @entity1 with a "healthy" dietary pattern, those with a "low fruit and vegetables" pattern and a "red meat and alcohol" (also characterized by lower intake of dairy products and vegetables) pattern showed a higher risk of @entity583 (OR 1.85, 95% CI 1.01 to 3.39 and OR 1.91, 95% CI 1.17 to 3.12, respectively). Female controls with the "red meat and alcohol" pattern also had a higher total to high-density lipoprotein @entity165 ratio. In comparison to @entity1 with a "healthy" pattern, those with the "red meat and alcohol" pattern, similar to the counterpart found in @entity1 , were more likely to experience an @entity583 (OR 1.98, 95% CI 1.35 to 2.92); male controls with this pattern had higher diastolic and systolic blood pressure, @entity1851 , and @entity414 levels. CONCLUSIONS: A dietary pattern with lower fruit and vegetable intakes in @entity1 , and a pattern characterized by higher consumption of red meat and @entity167 (and lower of dairy products and vegetables) in both sexes, were associated with an increased risk of @entity583 and adverse cardiovascular risk profiles. These findings highlight the importance of sustained recommendations for fruit and vegetable intake and cautious guidance on consumption of alcoholic beverages, which clusters with less healthy dietary patterns of @entity1 and @entity1 .

title: Major habitual dietary patterns are associated with XXXX and cardiovascular risk markers in a southern European population.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PARTICIPANTS', 'men']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']


abstract: PURPOSE: To analyze, in a prospective clinical trial, the efficacy and @entity137 of concurrent radiotherapy and chemotherapy with @entity136 and @entity900 in @entity1 with incompletely (R1) resected @entity788 . METHODS AND MATERIALS: Between 2000 and 2002, a total of 30 @entity788 @entity1 were treated. Radiotherapy was performed in 15 @entity1 up to a total dose of 45.0 Gy. An additional 15 @entity1 received a total dose of 50.0 Gy according to the International Commission on Radiation Units and Measurements (ICRU) Report 50 reference point (equivalent to 45.0 Gy at the isodose, including 90% covering the former @entity5 area and local lymph nodes). Concurrent with radiotherapy, four applications of @entity136 (300 mg/m(2)) and @entity900 (30 mg/m(2)) were administered. After chemoradiotherapy, @entity1 received four additional courses of @entity136 (1000 mg/m(2)) and @entity900 (50 mg/m(2)) on Days 1 and 15 in a 4-week cycle. RESULTS: The median progression-free survival was 10.6 months, and the median overall survival was 22.8 months. The 1-, 2-, and 3-year survival rate was 81%, 43%, and 26%, respectively. After completion of chemoradiotherapy, distant @entity3 was observed in 14 @entity1 during a median follow-up of 15.0 months (range, 4.6-30.0). One @entity1 developed both local recurrence and distant metastases. Hematologic @entity137 were the most prominent side effects ( @entity1431 Grade 3 and 4 in 53% and 7% and @entity882 Grade 3 and 4 in 33% and 7% of @entity1 , respectively). Grade 3 and 4 @entity137 was not observed. CONCLUSION: Postoperative chemoradiotherapy with @entity136 and @entity900 after incomplete (R1) resection of @entity3123 is safe and feasible. A prolonged progression-free survival suggests high local efficacy, translating into a benefit of overall survival. On the basis of the favorable outcome of @entity1 receiving @entity136 / @entity900 -based chemoradiotherapy, testing this combined treatment strategy appears warranted in a comparative trial.

title: Concurrent chemoradiotherapy with @entity136 and XXXX after incomplete (R1) resection of locally advanced @entity3123 .

entities_list: @entity3123 :: ('MESH:C562463', 'Disease') :: ['pancreatic carcinoma']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'GI toxicity', 'toxicities']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukopenia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']


abstract: PURPOSE: To analyze, in a prospective clinical trial, the efficacy and @entity137 of concurrent radiotherapy and chemotherapy with @entity136 and @entity900 in @entity1 with incompletely (R1) resected @entity788 . METHODS AND MATERIALS: Between 2000 and 2002, a total of 30 @entity788 @entity1 were treated. Radiotherapy was performed in 15 @entity1 up to a total dose of 45.0 Gy. An additional 15 @entity1 received a total dose of 50.0 Gy according to the International Commission on Radiation Units and Measurements (ICRU) Report 50 reference point (equivalent to 45.0 Gy at the isodose, including 90% covering the former @entity5 area and local lymph nodes). Concurrent with radiotherapy, four applications of @entity136 (300 mg/m(2)) and @entity900 (30 mg/m(2)) were administered. After chemoradiotherapy, @entity1 received four additional courses of @entity136 (1000 mg/m(2)) and @entity900 (50 mg/m(2)) on Days 1 and 15 in a 4-week cycle. RESULTS: The median progression-free survival was 10.6 months, and the median overall survival was 22.8 months. The 1-, 2-, and 3-year survival rate was 81%, 43%, and 26%, respectively. After completion of chemoradiotherapy, distant @entity3 was observed in 14 @entity1 during a median follow-up of 15.0 months (range, 4.6-30.0). One @entity1 developed both local recurrence and distant metastases. Hematologic @entity137 were the most prominent side effects ( @entity1431 Grade 3 and 4 in 53% and 7% and @entity882 Grade 3 and 4 in 33% and 7% of @entity1 , respectively). Grade 3 and 4 @entity137 was not observed. CONCLUSION: Postoperative chemoradiotherapy with @entity136 and @entity900 after incomplete (R1) resection of @entity3123 is safe and feasible. A prolonged progression-free survival suggests high local efficacy, translating into a benefit of overall survival. On the basis of the favorable outcome of @entity1 receiving @entity136 / @entity900 -based chemoradiotherapy, testing this combined treatment strategy appears warranted in a comparative trial.

title: Concurrent chemoradiotherapy with XXXX and @entity900 after incomplete (R1) resection of locally advanced @entity3123 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity136 :: (MESH:C056507,Chemical) :: ['gemcitabine']


abstract: PURPOSE: To analyze, in a prospective clinical trial, the efficacy and @entity137 of concurrent radiotherapy and chemotherapy with @entity136 and @entity900 in @entity1 with incompletely (R1) resected @entity788 . METHODS AND MATERIALS: Between 2000 and 2002, a total of 30 @entity788 @entity1 were treated. Radiotherapy was performed in 15 @entity1 up to a total dose of 45.0 Gy. An additional 15 @entity1 received a total dose of 50.0 Gy according to the International Commission on Radiation Units and Measurements (ICRU) Report 50 reference point (equivalent to 45.0 Gy at the isodose, including 90% covering the former @entity5 area and local lymph nodes). Concurrent with radiotherapy, four applications of @entity136 (300 mg/m(2)) and @entity900 (30 mg/m(2)) were administered. After chemoradiotherapy, @entity1 received four additional courses of @entity136 (1000 mg/m(2)) and @entity900 (50 mg/m(2)) on Days 1 and 15 in a 4-week cycle. RESULTS: The median progression-free survival was 10.6 months, and the median overall survival was 22.8 months. The 1-, 2-, and 3-year survival rate was 81%, 43%, and 26%, respectively. After completion of chemoradiotherapy, distant @entity3 was observed in 14 @entity1 during a median follow-up of 15.0 months (range, 4.6-30.0). One @entity1 developed both local recurrence and distant metastases. Hematologic @entity137 were the most prominent side effects ( @entity1431 Grade 3 and 4 in 53% and 7% and @entity882 Grade 3 and 4 in 33% and 7% of @entity1 , respectively). Grade 3 and 4 @entity137 was not observed. CONCLUSION: Postoperative chemoradiotherapy with @entity136 and @entity900 after incomplete (R1) resection of @entity3123 is safe and feasible. A prolonged progression-free survival suggests high local efficacy, translating into a benefit of overall survival. On the basis of the favorable outcome of @entity1 receiving @entity136 / @entity900 -based chemoradiotherapy, testing this combined treatment strategy appears warranted in a comparative trial.

title: Concurrent chemoradiotherapy with @entity136 and @entity900 after incomplete (R1) resection of locally advanced XXXX .

answer: @entity3123 :: (MESH:C562463,Disease) :: ['pancreatic carcinoma']


abstract: Luteinizing hormone (LH) concentrations and pulsatility are increased in @entity28 @entity1 with @entity3610 ( @entity3610 ). In addition, @entity1 have @entity3610 and insulin resistance. The mechanisms involved in aberrant hormone regulation in @entity3610 are still unclear. We investigated 15 @entity3610 @entity1 with a body mass index between 30 and 54 kg/m(2) and 9 healthy @entity28 controls (body mass index, 31-60 kg/m(2)) with regular menstrual cycles. Subjects underwent 24-hour blood sampling at 10-minute intervals for later measurements of LH, leptin, @entity251 , and insulin concentrations. Data were analyzed with a new deconvolution program, approximate entropy (and bivariate approximate entropy), and a cross-correlation network. @entity1 had increased LH pulse frequency and more than 2-fold greater daily LH secretion, with diminished pattern regularity. @entity251 secretion was increased 2-fold, but pattern regularity was similar to that in controls. In the network construct, insulin was correlated positively with LH, whereas leptin and @entity251 were correlated negatively with LH. Bivariate synchrony of LH with insulin was decreased. Short-term caloric restriction paradoxically increased LH secretion by 1.5-fold and pattern irregularity, and reduced interpulse variability. @entity251 secretion and fasting concentrations of @entity53 and @entity443 levels remained unchanged. Correlations between LH and insulin, leptin, and calculated free @entity251 decreased. This study demonstrates marked alterations in the control of LH secretion in @entity3610 in the fed and calorie-restricted states. The ensemble results point to abnormal feedback control of not only the @entity1176 -gonadotrope complex, but also LH's relationships with leptin, insulin, and @entity251 .

title: Altered multihormone synchrony in @entity28 @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovary syndrome', 'hyperandrogenemia', 'obese PCOS', 'PCOS']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity443 :: ('6462', 'Gene') :: ['sex hormone-binding globulin']

answer: @entity3610 :: (MESH:D011085,Disease) :: ['polycystic ovary syndrome']


abstract: Luteinizing hormone (LH) concentrations and pulsatility are increased in @entity28 @entity1 with @entity3610 ( @entity3610 ). In addition, @entity1 have @entity3610 and insulin resistance. The mechanisms involved in aberrant hormone regulation in @entity3610 are still unclear. We investigated 15 @entity3610 @entity1 with a body mass index between 30 and 54 kg/m(2) and 9 healthy @entity28 controls (body mass index, 31-60 kg/m(2)) with regular menstrual cycles. Subjects underwent 24-hour blood sampling at 10-minute intervals for later measurements of LH, leptin, @entity251 , and insulin concentrations. Data were analyzed with a new deconvolution program, approximate entropy (and bivariate approximate entropy), and a cross-correlation network. @entity1 had increased LH pulse frequency and more than 2-fold greater daily LH secretion, with diminished pattern regularity. @entity251 secretion was increased 2-fold, but pattern regularity was similar to that in controls. In the network construct, insulin was correlated positively with LH, whereas leptin and @entity251 were correlated negatively with LH. Bivariate synchrony of LH with insulin was decreased. Short-term caloric restriction paradoxically increased LH secretion by 1.5-fold and pattern irregularity, and reduced interpulse variability. @entity251 secretion and fasting concentrations of @entity53 and @entity443 levels remained unchanged. Correlations between LH and insulin, leptin, and calculated free @entity251 decreased. This study demonstrates marked alterations in the control of LH secretion in @entity3610 in the fed and calorie-restricted states. The ensemble results point to abnormal feedback control of not only the @entity1176 -gonadotrope complex, but also LH's relationships with leptin, insulin, and @entity251 .

title: Altered multihormone synchrony in XXXX @entity1 with @entity3610 .

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: Luteinizing hormone (LH) concentrations and pulsatility are increased in @entity28 @entity1 with @entity3610 ( @entity3610 ). In addition, @entity1 have @entity3610 and insulin resistance. The mechanisms involved in aberrant hormone regulation in @entity3610 are still unclear. We investigated 15 @entity3610 @entity1 with a body mass index between 30 and 54 kg/m(2) and 9 healthy @entity28 controls (body mass index, 31-60 kg/m(2)) with regular menstrual cycles. Subjects underwent 24-hour blood sampling at 10-minute intervals for later measurements of LH, leptin, @entity251 , and insulin concentrations. Data were analyzed with a new deconvolution program, approximate entropy (and bivariate approximate entropy), and a cross-correlation network. @entity1 had increased LH pulse frequency and more than 2-fold greater daily LH secretion, with diminished pattern regularity. @entity251 secretion was increased 2-fold, but pattern regularity was similar to that in controls. In the network construct, insulin was correlated positively with LH, whereas leptin and @entity251 were correlated negatively with LH. Bivariate synchrony of LH with insulin was decreased. Short-term caloric restriction paradoxically increased LH secretion by 1.5-fold and pattern irregularity, and reduced interpulse variability. @entity251 secretion and fasting concentrations of @entity53 and @entity443 levels remained unchanged. Correlations between LH and insulin, leptin, and calculated free @entity251 decreased. This study demonstrates marked alterations in the control of LH secretion in @entity3610 in the fed and calorie-restricted states. The ensemble results point to abnormal feedback control of not only the @entity1176 -gonadotrope complex, but also LH's relationships with leptin, insulin, and @entity251 .

title: Altered multihormone synchrony in @entity28 XXXX with @entity3610 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity241 ( @entity241 ) is a locally aggressive cutaneous @entity5 that exhibits a marked tendency for recurrence after local excision. This case series aims to study the clinical, histological and immunohistochemical features of @entity241 in Asians. Ten @entity1 with @entity241 diagnosed between 1992 and 2001 were reviewed. There were more @entity1 than @entity1 in a ratio of 4:1. There were six Chinese, two Malays, one Indian and one Eurasian. The mean age was 38 years. The duration of each lesion before excision varied from 6 months to 27 years. Fifty per cent of @entity5 occurred on the trunk. On histology, all the lesions were dermal-centred spindle cell @entity5 , extending to the subcutis, and exhibited the characteristic storiform pattern. One @entity5 also demonstrated @entity241 . Two @entity5 were of the rare pigmented variant ( @entity5 ). Immunohistochemistry with @entity2280 was positive in all cases, except the @entity5 , which was negative for @entity2280 . For comparison, six cases of deep-penetrating @entity3074 were stained for @entity2280 and all showed an absence of @entity2280 expression. Wide excision of the @entity5 was performed in all cases of @entity241 . There was no recurrence after mean follow up of 6 years (range 2.25-9.5 years).

title: XXXX : a clinicopathological analysis of 10 cases in Asians.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'Bednar tumour', 'tumours', 'fibrosarcomatous area of one tumour', 'neoplasm']

entities_list: @entity241 :: ('MESH:D018223', 'Disease') :: ['fibrosarcomatous changes', 'Dermatofibrosarcoma protuberans', 'DFSP']

entities_list: @entity3074 :: ('MESH:D018219', 'Disease') :: ['dermatofibroma']

answer: @entity241 :: (MESH:D018223,Disease) :: ['Dermatofibrosarcoma protuberans']


abstract: BACKGROUND: Hospital registries are an important component of @entity5 screening efforts of individuals and communities. This paper describes the structure and goals of a @entity1049 Family Registry at a metropolitan hospital. @entity1 characteristics, differences between @entity344 among probands, subjective distress in relation to perception of @entity14 , and quality of life were examined. METHODS: @entity1 were @entity1 with @entity14 ( @entity14 ), @entity1412 ( @entity1412 ), @entity14 ( @entity14 ) and inflammatory bowel disease @entity31 ( @entity31 ) and @entity30 representing a range of @entity1049 . A total of 630 probands were recruited into the registry and administered a questionnaire. RESULTS: Of the 630 probands, 198 (31.4%) were diagnosed with @entity14 , 36 (5.3%) with @entity1412 or @entity14 and 272 (43.2%) with @entity31 or @entity30 . The majority of all three groups had some level of college education, was white, and reported a household income greater then  70,000. The Impact of Event Scale score was found to be of notable significance when categorized by relation to proband (p<0.01) and proband diagnoses (p  <= 0.000). On the quality of life item, the largest difference was between @entity1412 or @entity14 and @entity31 or @entity30 without @entity14 . CONCLUSION: Subjective distress scores were higher for @entity14 probands in comparison to probands with other @entity14 . Quality of life was relatively high for all probands. @entity458 should be explored in more depth and more frequently to screen for any concomitant @entity146 disorders like post-traumatic symptoms that have been linked to a @entity5 diagnosis.

title: Descriptive characteristics of a XXXX family registry at an urban hospital.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient', 'Participants']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal diseases']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['Psychological distress']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['HNPCC', 'CRC', 'colorectal cancer', 'hereditary nonpolyposis colorectal carcinoma', 'colorectal diseases']

entities_list: @entity1412 :: ('MESH:D011125', 'Disease') :: ['familial adenomatous polyposis', 'FAP']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's", "Crohn's disease"]

entities_list: @entity1049 :: ('MESH:D003108', 'Disease') :: ['Colon Disease', 'colonic diseases']

answer: @entity1049 :: (MESH:D003108,Disease) :: ['colon disease']