abstract: Glucocorticoid receptors were quantitated by a whole cell method in cells from 593 @entity1 with @entity3052 at the time of diagnosis. @entity1778 cells were also immunologically typed and divided into early pre-B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-negative, cytoplasmic immunoglobulin-negative), pre-B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-negative, cytoplasmic immunoglobulin-positive), B- (not reactive with antibodies to T-lymphocyte antigens, surface immunoglobulin-positive), and T- (reactive with antibodies to T-lymphocyte antigens) subtypes. There was a median of 9.7 X 10(3) sites per cell in the 359 with early pre-B- @entity981 , a median of 8.1 X 10(3) sites per cell from 103 @entity1 with @entity8624 , and a median of 4.0 X 10(3) sites per cell from 116 @entity1 with @entity1619 . The distributions per cell were significantly different among these 3 groups (P less than 0.0001). The 15 @entity1 with B-cell disease had a median of 3.2 X 10(3) sites per cell. At the time of analysis, remission induction data are available for most of these @entity1 . Within the early pre-B- group 291 @entity1 with a median receptor number of 9.9 X 10(3) achieved remission, while 13 with a median receptor number of 4.8 X 10(3) did not. These distributions were significantly different (P = 0.034). Within the pre-B- and T-cell groups the distributions of receptor numbers for responders and non-responders were not significantly different. We conclude that each immunological subtype has characteristic receptor distribution. High receptor number within the null group is associated with the ability of the @entity1 to achieve remission; however, the range of values within each @entity1 group is too broad to use this assay as a predictor of response for any individual @entity1 .

title: Glucocorticoid receptors in immunological subtypes of childhood XXXX cells: a Pediatric Oncology Group Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphocytic leukemia']

entities_list: @entity1619 :: ('MESH:D015458', 'Disease') :: ['T-cell leukemia']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute leukemia']

entities_list: @entity8624 :: ('MESH:D015448', 'Disease') :: ['pre-B-cell leukemia']

answer: @entity981 :: (MESH:D054198,Disease) :: ['acute lymphocytic leukemia']


abstract: Forty-five @entity1 and fifteen @entity1 with @entity2013 have been treated surgically. @entity1 with @entity5 received pituitary irradiation and postoperative @entity4089 was treated with @entity2847 . The @entity1 have been followed-up for 6-36 months following the operation. The @entity5 were larger and the levels of production higher in @entity1 as compared with @entity1 . All @entity1 had @entity4999 . @entity21696 was present in forty-three @entity1 but not in the @entity1 . After surgery serum @entity4090 levels fell significantly in all @entity1 but remained above normal in thirty-six; @entity4090 remained high in twelve @entity1 . @entity2847 effectively decreased the postoperative @entity4089 . The surgical complications were @entity2895 in one @entity1 and one @entity1 . After surgery six (23%) @entity1 developed @entity73 , six (15%) @entity1374 , eight (18%) impaired @entity701 secretion and five (17%) impaired LH secretion in isolation or combination which had not been present preoperatively. Three @entity1 relapsed. Fifteen @entity1 menstruated after surgery and ten began to do so during the subsequent @entity2847 treatment. Thus, menstruation was restored in all six @entity1 with microadenomas in sixteen of twenty @entity1 with intrasellar macroadenomas and three of nineteen @entity1 with suprasellar @entity652 . The preoperative LH-reserve proved to be an important prognostic indicator. Nine @entity1 , i.e. 50% of @entity1 desiring fertility became pregnant. In the @entity1 gonadal function deteriorated in four @entity1 and did not improve in any without @entity251 treatment.

title: Pituitary function in @entity2013 . Effect of surgery and postoperative XXXX therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'man', 'women', 'Patients', 'woman', 'patients']

entities_list: @entity4089 :: ('MESH:D006966', 'Disease') :: ['hyperprolactinaemia']

entities_list: @entity2847 :: ('MESH:D001971', 'Chemical') :: ['Bromocriptine', 'bromocriptine']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity2013 :: ('MESH:D015175', 'Disease') :: ['prolactinomas']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['impaired thyroid function']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['large tumours', 'tumours']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired GH secretion']

entities_list: @entity2895 :: ('MESH:D015840', 'Disease') :: ['oculomotor nerve paresis']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']

entities_list: @entity21696 :: ('MESH:C535402', 'Disease') :: ['Galactorrhoea']

entities_list: @entity4999 :: ('MESH:C537962', 'Disease') :: ['amenorrhoea']

answer: @entity2847 :: (MESH:D001971,Chemical) :: ['bromocriptine']


abstract: Forty-five @entity1 and fifteen @entity1 with @entity2013 have been treated surgically. @entity1 with @entity5 received pituitary irradiation and postoperative @entity4089 was treated with @entity2847 . The @entity1 have been followed-up for 6-36 months following the operation. The @entity5 were larger and the levels of production higher in @entity1 as compared with @entity1 . All @entity1 had @entity4999 . @entity21696 was present in forty-three @entity1 but not in the @entity1 . After surgery serum @entity4090 levels fell significantly in all @entity1 but remained above normal in thirty-six; @entity4090 remained high in twelve @entity1 . @entity2847 effectively decreased the postoperative @entity4089 . The surgical complications were @entity2895 in one @entity1 and one @entity1 . After surgery six (23%) @entity1 developed @entity73 , six (15%) @entity1374 , eight (18%) impaired @entity701 secretion and five (17%) impaired LH secretion in isolation or combination which had not been present preoperatively. Three @entity1 relapsed. Fifteen @entity1 menstruated after surgery and ten began to do so during the subsequent @entity2847 treatment. Thus, menstruation was restored in all six @entity1 with microadenomas in sixteen of twenty @entity1 with intrasellar macroadenomas and three of nineteen @entity1 with suprasellar @entity652 . The preoperative LH-reserve proved to be an important prognostic indicator. Nine @entity1 , i.e. 50% of @entity1 desiring fertility became pregnant. In the @entity1 gonadal function deteriorated in four @entity1 and did not improve in any without @entity251 treatment.

title: Pituitary function in XXXX . Effect of surgery and postoperative @entity2847 therapy.

answer: @entity2013 :: (MESH:D015175,Disease) :: ['prolactinoma']


abstract: 1. Mucus samples obtained from colectomy colons from 10 @entity1 with @entity31 and four @entity1 with @entity30 of the colon, together with samples from 10 normal postmortem colons, have been studied. 2. Two glycoprotein fractions were isolated from mucosal scrapings by gel-permeation chromatography. The high-molecular-weight fraction consisted largely of mucus glycoproteins and was further purified to the glycopolypeptides. The low-molecular-weight fraction contained a glycoprotein with a high @entity3913 content. The @entity1735 content of both the mucus glycoprotein and glycopolypeptide fractions were significantly reduced in active @entity1960 . 3. Oligosaccharides were prepared from the mucus glycoprotein material. In the normal material more than half the units contained eight or more @entity9928 residues, whereas in the disease material the bulk of the units were smaller than this.

title: Study of the XXXX content of mucus glycoproteins from normal and diseased colons.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity9928 :: ('CHEBI:35381', 'Chemical') :: ['monosaccharide']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

answer: @entity1735 :: (CHEBI:16646,Chemical) :: ['carbohydrate']


abstract: Peripheral plasma concentrations of @entity18314 (PGFM), @entity1420 , @entity4090 and @entity7042 were determined in 20 sows for two days before and three weeks after parturition. Groups of four sows each received one of the following five treatments post partum: 30 ml sterile 0.9 per cent saline solution intrauterinely; ovariectomy and 30 ml saline solution intrauterinely; 10 ml Lugol's @entity1496 plus 20 ml saline solution intrauterinely; ovariectomy and 10 ml Lugol's @entity1496 plus 20 ml saline solution intrauterinely, or @entity1420 (0.5 mg [kg bodyweight]-1 intramuscularly). Saline solution and @entity1496 were administered every 48 hours, @entity1021 immediately after parturition, for one week. Ovariectomy was performed within eight hours of delivery. @entity1420 was given every third day for 12 days. Piglet weight gains were used as a reflection of milk yield. In all sows, @entity7042 values were elevated before parturition, but fell by the end of delivery and were very low during lactation. PGFM concentrations rose during the last two days of pregnancy to reach maximal values at the time of delivery. Plasma @entity1420 levels declined concomitantly with the rise in PGFM values before parturition. Basal values of @entity1420 were achieved within 24 hours after delivery in control sows receiving saline treatment. @entity1420 values fell immediately after ovariectomy in sows receiving saline or @entity1496 treatment but were slightly elevated for one week in sows that received only intrauterine @entity1496 treatment, suggesting that complete regression of corpora lutea is prevented by suppression of post parturient uterine prostaglandin production. Sows injected with @entity1420 maintained plasma values of about 5 to 15 nmol litre-1.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Prostaglandin F2 alpha and XXXX in experimental hypogalactia in sows.

entities_list: @entity18314 :: ('MESH:C008228', 'Chemical') :: ['13,14-dihydro-15-keto-prostaglandin F2alpha']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone', 'Progesterone']

entities_list: @entity7042 :: ('CHEBI:17263', 'Chemical') :: ['oestrone']

answer: @entity4090 :: (5617,Gene) :: ['prolactin']


abstract: Serum radioimmunoassayable @entity251 (T), @entity701 and luteinizing hormone (LH) were determined before and after @entity619 ( @entity3784 ) administration in 35 @entity1 with @entity3427 ( @entity3427 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity3784 conditions. @entity251 values obtained in 5 normal @entity1 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity3784 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity1 with @entity3427 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity3784 , 1.67 +/- 1.49nmol/l. @entity1 with @entity3427 were divided into 4 groups according to T results in the @entity3784 test (mean +/- SD in both basal and post- @entity3784 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity701 , was obtained. No LH modifications after @entity3784 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity3427 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum XXXX obtained in multiple blood samples from @entity1 with @entity3427 in both basal and post- @entity619 conditions.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone', 'Testosterone']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity3427 :: ('MESH:D006628', 'Disease') :: ['idiopathic hirsutism', 'IH']

answer: @entity251 :: (MESH:D013739,Chemical) :: ['testosterone']


abstract: Serum radioimmunoassayable @entity251 (T), @entity701 and luteinizing hormone (LH) were determined before and after @entity619 ( @entity3784 ) administration in 35 @entity1 with @entity3427 ( @entity3427 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity3784 conditions. @entity251 values obtained in 5 normal @entity1 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity3784 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity1 with @entity3427 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity3784 , 1.67 +/- 1.49nmol/l. @entity1 with @entity3427 were divided into 4 groups according to T results in the @entity3784 test (mean +/- SD in both basal and post- @entity3784 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity701 , was obtained. No LH modifications after @entity3784 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity3427 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum @entity251 obtained in multiple blood samples from @entity1 with @entity3427 in both basal and post- XXXX conditions.

answer: @entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']


abstract: Serum radioimmunoassayable @entity251 (T), @entity701 and luteinizing hormone (LH) were determined before and after @entity619 ( @entity3784 ) administration in 35 @entity1 with @entity3427 ( @entity3427 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity3784 conditions. @entity251 values obtained in 5 normal @entity1 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity3784 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity1 with @entity3427 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity3784 , 1.67 +/- 1.49nmol/l. @entity1 with @entity3427 were divided into 4 groups according to T results in the @entity3784 test (mean +/- SD in both basal and post- @entity3784 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity701 , was obtained. No LH modifications after @entity3784 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity3427 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum @entity251 obtained in multiple blood samples from @entity1 with XXXX in both basal and post- @entity619 conditions.

answer: @entity3427 :: (MESH:D006628,Disease) :: ['idiopathic hirsutism']


abstract: Serum radioimmunoassayable @entity251 (T), @entity701 and luteinizing hormone (LH) were determined before and after @entity619 ( @entity3784 ) administration in 35 @entity1 with @entity3427 ( @entity3427 ). Blood samples were taken at 15-min intervals during 1 hour in both basal and post- @entity3784 conditions. @entity251 values obtained in 5 normal @entity1 in the same conditions during the early follicular phase were (mean +/- SD): baseline, 2.26 +/- 0.49 nmol/l; post- @entity3784 , 0.80 +/- 0.35 nmol/l. Serum T levels in the whole group of @entity1 with @entity3427 were significantly higher than those in the control group (mean +/- SD): baseline, 3.30 +/- 1.80nmol/l; post- @entity3784 , 1.67 +/- 1.49nmol/l. @entity1 with @entity3427 were divided into 4 groups according to T results in the @entity3784 test (mean +/- SD in both basal and post- @entity3784 conditions, respectively): group 1 (n = 13) 1.67 +/- 0.66 and 0.62 +/- 0.35nmol/l; group 2 (n = 11) 3.89 +/- 1.63 and 3.09 +/- 1.49nmol/l; group 3 (n = 6) 3.96 +/- 1.46 and 0.87 +/- 0.73nmol/l; and group 4 (n = 5) 5.45 +/- 1.25 and 2.05 +/- 0.38nmol/l. In all cases, maximal adrenal inhibition, as judged by serum @entity701 , was obtained. No LH modifications after @entity3784 were obtained in any of the cases. Our results demonstrate that there is no common androgenic abnormality in @entity3427 . It is possible to obtain normal or high circulating T levels. The findings of this study also suggest that the adrenals, to ovary or both may be the sources of high T levels.

title: Heterogeneous results of serum @entity251 obtained in multiple blood samples from XXXX with @entity3427 in both basal and post- @entity619 conditions.

answer: @entity1 :: (9606,Species) :: ['women']


abstract: OBJECTIVE: To evaluate the feasibility of tracking @entity12279 ( @entity8681 )-wrapped superparamagnetic @entity1933 (SPIO) nanoparticle-labeled, bone marrow-derived mesenchymal stem cells (BMSCs) by in vivo magnetic resonance imaging (MRI) in articular cartilage repair in a minipig model. METHODS: Eighteen Guizhou minipigs were randomly divided into three groups (groups A, B, and C). In group A, @entity8681 -wrapped SPIO nanoparticle ( @entity8681 /SPIO) and green fluorescent protein (GFP) colabeled, autologous BMSCs seeded in type II collagen gel were transplanted into the articular cartilage defects of the minipig model. In group B, GFP-labeled, autologous BMSCs seeded in type II collagen gel were transplanted. In group C, no treatment was applied for cartilage defects. All minipigs underwent clinical 3.0-T MR imaging at 4, 8, 12, and 24 weeks postsurgery. The findings were compared histologically. RESULTS: Prussian staining and transmission electron microscope showed that BMSCs were efficiently labeled by @entity8681 /SPIO. Cell viability, proliferation, and differentiation were comparable between labeled and unlabeled cells. MRI @entity21044 WI sequence revealed that marked @entity2654 representing the transplanted labeled BMSCs could be observed for at least 24 weeks. Histochemical staining confirmed the presence of Prussian blue-positive cells and GFP-positive cells at the @entity2654 . At 24 weeks postsurgery, both MR signals and histologic staining of minipigs in groups A and B at the cartilage defect were close to the normal cartilage. CONCLUSIONS: 3.0-T MRI in vivo tracking of @entity8681 /SPIO-labeled BMSCs seeded in type II collagen gel on cartilage repair following transplantation is feasible in minipigs.

title: In Vivo MRI Tracking of XXXX -Wrapped Superparamagnetic @entity1933 Nanoparticle-Labeled BMSCs for Cartilage Repair: A Minipig Model.

entities_list: @entity12279 :: ('MESH:D011094', 'Chemical') :: ['polyethylenimine']

entities_list: @entity1933 :: ('MESH:C000499', 'Chemical') :: ['iron oxide']

entities_list: @entity2654 :: ('MESH:C537271', 'Disease') :: ['hypointense signal void areas']

answer: @entity12279 :: (MESH:D011094,Chemical) :: ['Polyethylenimine']


abstract: OBJECTIVE: To evaluate the feasibility of tracking @entity12279 ( @entity8681 )-wrapped superparamagnetic @entity1933 (SPIO) nanoparticle-labeled, bone marrow-derived mesenchymal stem cells (BMSCs) by in vivo magnetic resonance imaging (MRI) in articular cartilage repair in a minipig model. METHODS: Eighteen Guizhou minipigs were randomly divided into three groups (groups A, B, and C). In group A, @entity8681 -wrapped SPIO nanoparticle ( @entity8681 /SPIO) and green fluorescent protein (GFP) colabeled, autologous BMSCs seeded in type II collagen gel were transplanted into the articular cartilage defects of the minipig model. In group B, GFP-labeled, autologous BMSCs seeded in type II collagen gel were transplanted. In group C, no treatment was applied for cartilage defects. All minipigs underwent clinical 3.0-T MR imaging at 4, 8, 12, and 24 weeks postsurgery. The findings were compared histologically. RESULTS: Prussian staining and transmission electron microscope showed that BMSCs were efficiently labeled by @entity8681 /SPIO. Cell viability, proliferation, and differentiation were comparable between labeled and unlabeled cells. MRI @entity21044 WI sequence revealed that marked @entity2654 representing the transplanted labeled BMSCs could be observed for at least 24 weeks. Histochemical staining confirmed the presence of Prussian blue-positive cells and GFP-positive cells at the @entity2654 . At 24 weeks postsurgery, both MR signals and histologic staining of minipigs in groups A and B at the cartilage defect were close to the normal cartilage. CONCLUSIONS: 3.0-T MRI in vivo tracking of @entity8681 /SPIO-labeled BMSCs seeded in type II collagen gel on cartilage repair following transplantation is feasible in minipigs.

title: In Vivo MRI Tracking of @entity12279 -Wrapped Superparamagnetic XXXX Nanoparticle-Labeled BMSCs for Cartilage Repair: A Minipig Model.

answer: @entity1933 :: (MESH:C000499,Chemical) :: ['Iron Oxide']


abstract: OBJECTIVE: To predict, using clinical and qMRI data, the incidence of total knee replacement (TKR) during the long-term follow-up of @entity626 ( @entity571 ) @entity1 who formerly received chondroitin sulfate (CS) or placebo treatment. DESIGN: A post hoc intention-to-treat analysis to evaluate the incidence of TKR was done on knee @entity571 @entity1 who had participated in a 12-month trial evaluating the impact of CS (800 mg/d) versus placebo for 6 months, followed by a 6-month open-phase in which all @entity1 received CS. Additionally, the clinical and qMRI predictors of TKR were determined. RESULTS: Thirteen TKRs were performed in the population after a 4-year follow-up. More TKRs were performed in the placebo group than in the CS group (69% vs. 31%, P = 0.150, logistic regression). The statistically significant predictors of TKRs were, at baseline, higher WOMAC @entity158 and function scores, presence of @entity236 ( @entity236 ), and higher @entity1851 levels. Loss of medial cartilage volume and increase in WOMAC @entity158 and function at one-year were also predictors of TKR. Multivariate analyses revealed that baseline presence of BML and higher WOMAC @entity158 score were independent predictors. Time to occurrence of the TKR also favored the CS group versus placebo (log-rank, P = 0.094). CONCLUSION: Symptoms such as knee @entity158 and function, presence of BML, and cartilage @entity393 predict the long-term occurrence of a "hard" outcome such as TKR.

title: Total Knee Replacement as a XXXX Outcome: Predictors Derived from a 4-Year Long-Term Observation following a Randomized Clinical Trial Using Chondroitin Sulfate.

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow lesions', 'BMLs']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['volume loss']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity626 :: (MESH:D020370,Disease) :: ['Knee Osteoarthritis']


abstract: BACKGROUND: Skeletal muscle depletion ( @entity6288 ) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in @entity1 with unresectable @entity14 ( @entity14 ). METHODS: We conducted a retrospective analysis of 215 consecutive @entity1 with unresectable @entity14 who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy. RESULTS: One-hundred-eighty-two @entity1 met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or @entity1349 ( @entity1349 ) associated with skeletal muscle mass before chemotherapy. However, 22 @entity1 with skeletal @entity121 (>5%) after chemotherapy showed significantly shorter PFS and @entity1349 compared with those without skeletal @entity121 (PFS, log-rank p = 0.029; @entity1349 , log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal @entity121 after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with @entity1349 . CONCLUSIONS: Skeletal @entity121 after chemotherapy was an independent, negative prognostic factor in unresectable @entity14 .

title: Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in @entity1 with Unresectable XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6288 :: ('MESH:D055948', 'Disease') :: ['sarcopenia']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle loss']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: BACKGROUND: Skeletal muscle depletion ( @entity6288 ) is closely associated with limited physical ability and high mortality. This study evaluated the prognostic significance of skeletal muscle status before and after chemotherapy in @entity1 with unresectable @entity14 ( @entity14 ). METHODS: We conducted a retrospective analysis of 215 consecutive @entity1 with unresectable @entity14 who underwent systemic chemotherapy. Skeletal muscle cross-sectional area was measured by computed tomography. We evaluated the prognostic value of skeletal muscle mass before chemotherapy and the rate of skeletal muscle change in cross-sectional area after chemotherapy. RESULTS: One-hundred-eighty-two @entity1 met our inclusion criteria. There were no significant differences in progression-free survival (PFS) or @entity1349 ( @entity1349 ) associated with skeletal muscle mass before chemotherapy. However, 22 @entity1 with skeletal @entity121 (>5%) after chemotherapy showed significantly shorter PFS and @entity1349 compared with those without skeletal @entity121 (PFS, log-rank p = 0.029; @entity1349 , log-rank p = 0.009). Multivariate Cox regression analysis revealed that skeletal @entity121 after chemotherapy (hazard ratio, 2.079; 95% confidence interval, 1.194-3.619; p = 0.010) was independently associated with @entity1349 . CONCLUSIONS: Skeletal @entity121 after chemotherapy was an independent, negative prognostic factor in unresectable @entity14 .

title: Negative Impact of Skeletal Muscle Loss after Systemic Chemotherapy in XXXX with Unresectable @entity14 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVES: Since 1999, we have performed implantations of Remeex   adjustable prosthetics as rescue treatment for complex or persistent stress @entity322 (SUI) after failure of other surgical treatments (Burch colposuspension, Marshall-Marchetti-Krantz (MMK) or tension-free transvaginal tape [TVT] until 2003 and transobturator tape [TOT] since 2003). We present the results of our series, which include cases with severe complications. MATERIAL AND METHOD: Retrospective study of @entity1 diagnosed with complex or refractory SUI who underwent Remeex(  ) implantation between October 1999 and December 2013. In 5 cases, we conducted cystocele correction in the same operation as the placement of the Remeex(  ). RESULTS: Sixty @entity1 , with a mean age of 66.87 years (range 39-85), underwent operations. The procedure was successful in 68.33% of the cases. The failures consisted of the following: 10% of the @entity1 had mixed @entity322 ( @entity322 ) with @entity1494 ; 8.33% had mild SUI; and 13.33% had urgency urination without @entity322 . Thirty-five percent required adjustments. We recorded 3 cases with severe complications: disabling severe @entity322 in a @entity1 who underwent multiple operations, massive @entity548 in a @entity1 undergoing standard antiplatelet therapy and infected vaginal calculi measuring 7cm on an extruding Remeex thread in a paraplegic @entity1 4 years after the implantation. CONCLUSIONS: Remeex(  ) is an effective and safe procedure for achieving continence in cases of complex or refractory SUI, although it is not exempt from severe complications. Following rigorous protocols can help detect complications and treat them in a timely manner.

title: Severe complications and failures of XXXX surgery using the Remeex(  ) adjustable tension sling (external mechanical regulator).

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence', 'UI']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['multiple bladder diverticula']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['pelvic hemorrhage']

answer: @entity322 :: (MESH:D014549,Disease) :: ['incontinence']


abstract: OBJECTIVES: In addition to exhibiting a severe contralesional deficit, @entity2300 @entity1 may also show a @entity227 , called sightblindness (the reverse case of 'blindsight). We have tested for the presence, nature and extent of such an @entity227 in @entity2300 @entity1 that we assigned to perform two visual tasks. Namely, we aimed to ascertain any links between this @entity51 , the lesion side, and the tasks performed or the stimuli used. METHODS: We tested left and right homonymous @entity2300 (right brain-damaged RBD and left brain-damaged @entity21244 , respectively) @entity1 and healthy controls. Natural-scene images, either non-filtered or filtered in low or high spatial frequency (LSF or @entity650 , respectively) were presented in the @entity227 of each subject. For the two tasks, detection ("Is an image present?") and categorization ("Is the image of a forest or a city?"), accuracy and response time were recorded. RESULTS: In the @entity227 the RBD (left hemianopes) @entity1 made more errors on the categorization task than did their matched controls, regardless of image type. In contrast, the only task in which the @entity21244 ( @entity2300 ) @entity1 made more errors than did the controls was the @entity650 -images task. Furthermore, in both tasks (detection and categorization), the RBD @entity1 performed worse than did the @entity21244 @entity1 . DISCUSSION: @entity1805 @entity1 do indeed exhibit a specific @entity227 in their @entity227 , which was previously thought to be unaffected. We have demonstrated that the nature and severity of this @entity51 is determined by the side of the @entity75 as well as by the tasks and the stimuli. Our findings corroborate the idea of hemispheric specialization at the occipital level, which might determine the nature and severity of @entity51 in @entity2300 @entity1 .

title: Hemisphere-dependent @entity51 in XXXX : Sightblindness in the 'intact' visual field.

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['IVF', 'visual deficit', 'subtle ipsilesional visual deficit', 'ipsilesional visual field (IVF) deficit']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['occipital lesion']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['ipsilesional deficit', 'ipsilesional deficits']

entities_list: @entity1805 :: ('MESH:D006423', 'Disease') :: ['Homonymous hemianopic']

entities_list: @entity2300 :: ('MESH:D011681', 'Disease') :: ['hemianopic', 'right hemianopes']

answer: @entity1805 :: (MESH:D006423,Disease) :: ['hemianopia']


abstract: OBJECTIVES: In addition to exhibiting a severe contralesional deficit, @entity2300 @entity1 may also show a @entity227 , called sightblindness (the reverse case of 'blindsight). We have tested for the presence, nature and extent of such an @entity227 in @entity2300 @entity1 that we assigned to perform two visual tasks. Namely, we aimed to ascertain any links between this @entity51 , the lesion side, and the tasks performed or the stimuli used. METHODS: We tested left and right homonymous @entity2300 (right brain-damaged RBD and left brain-damaged @entity21244 , respectively) @entity1 and healthy controls. Natural-scene images, either non-filtered or filtered in low or high spatial frequency (LSF or @entity650 , respectively) were presented in the @entity227 of each subject. For the two tasks, detection ("Is an image present?") and categorization ("Is the image of a forest or a city?"), accuracy and response time were recorded. RESULTS: In the @entity227 the RBD (left hemianopes) @entity1 made more errors on the categorization task than did their matched controls, regardless of image type. In contrast, the only task in which the @entity21244 ( @entity2300 ) @entity1 made more errors than did the controls was the @entity650 -images task. Furthermore, in both tasks (detection and categorization), the RBD @entity1 performed worse than did the @entity21244 @entity1 . DISCUSSION: @entity1805 @entity1 do indeed exhibit a specific @entity227 in their @entity227 , which was previously thought to be unaffected. We have demonstrated that the nature and severity of this @entity51 is determined by the side of the @entity75 as well as by the tasks and the stimuli. Our findings corroborate the idea of hemispheric specialization at the occipital level, which might determine the nature and severity of @entity51 in @entity2300 @entity1 .

title: Hemisphere-dependent XXXX in @entity1805 : Sightblindness in the 'intact' visual field.

answer: @entity51 :: (MESH:D009461,Disease) :: ['ipsilesional deficits']


abstract: UNASSIGNED: Impairments in the mirror neuron system (MNS) have been implicated as a possible underlying neurological basis for @entity73 in @entity161 . Previous work testing this hypothesis has used the electroencephalographic mu rhythm as an index of MNS activity, with studies showing mixed results. Here we investigated the role that reward plays in modulating the mu rhythm, and its association with empathy and emotional mental state reasoning. A group of @entity161 @entity1 and a healthy control group completed an action observation paradigm in which they watched actions that were financially rewarding, punishing, or neutral. @entity1 showed intact reward-related modulation of the mu rhythm, and greater mu suppression was associated with greater negative symptoms. There was also a trend for reduced mu suppression in @entity1 . Furthermore, both empathy and emotional mental state reasoning were associated with the degree of mu suppression, but only in healthy controls. These findings confirm the association between the mu suppression and high-level social cognition. It is possible that @entity161 @entity1 @entity73 to infer mental states. The demonstration that reward influences the degree of mu suppression in @entity161 @entity1 may help to account for previous conflicting findings in the literature.

title: Reward modulates the mirror neuron system in XXXX : A study into the mu rhythm suppression, empathy, and mental state attribution.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['deficits in higher-level social cognition', 'utilize different cognitive routes']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: BACKGROUND: Apolipoprotein (apo) distribution and lipoprotein (Lp)-associated markers of @entity32 , such as @entity6511 ( @entity6511 ), influence the atherogenicity of circulating lipids and lipoproteins. Little evidence exists regarding the dose-response effects of the marine @entity9539 @entity7784 ( @entity8393 ) and @entity4600 ( @entity4601 ) on apos, apo-defined Lps, and @entity6511 . OBJECTIVE: The purpose of this study was to compare the effects of 0, 0.85, and 3.4  g/d of @entity8393  +  @entity4601 on @entity6511 mass and activity in individuals with moderate @entity2298 . We also measured effects on concentrations of apoAI, @entity3294 , @entity755 , apoC, @entity16990 , and @entity2204 -defined Lp subclasses. METHODS: The study was a randomized, doubleblind, crossover design with 8-week treatment periods and 6-week washout periods. During the 3 treatment periods, subjects (n  =  25) received 0  g/d @entity8393  +  @entity4601 , 0.85  g/d @entity8393  +  @entity4601 (low dose), and 3.4  g/d @entity8393  +  @entity4601 (high dose) in random order. RESULTS: @entity755 and @entity12436 were significantly decreased by the high dose relative to placebo and low dose (P  <  .01), as was very low-density lipoprotein @entity165 (P  <  .005). The low dose had no effect on Lp outcomes compared with placebo. The high- and low-dose effects differed significantly for heparin-precipitated @entity12436 , LpB, LpA-I, and @entity755 / @entity1675 ratio (P  <  .05). There was a trend for a decreased @entity6511 mass with the high dose (P  =  .1). CONCLUSION: The effects of 3.4  g/d @entity8393  +  @entity4601 on @entity755 and @entity12436 may reduce @entity731 in individuals with elevated @entity1674 .

title: Dose-response effects of marine XXXX on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and @entity6511 in individuals with moderate @entity2298 .

entities_list: @entity2298 :: ('MESH:D015228', 'Disease') :: ['hypertriglyceridemia']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity7784 :: ('MESH:D015118', 'Chemical') :: ['eicosapentaenoic acid']

entities_list: @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity6511 :: ('7941', 'Gene') :: ['Lp-PLA2', 'lipoprotein-associated phospholipase A2']

entities_list: @entity9539 :: ('MESH:D015525', 'Chemical') :: ['omega-3 fatty acids']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic plaque progression']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity9539 :: (MESH:D015525,Chemical) :: ['omega-3 fatty acids']


abstract: BACKGROUND: Apolipoprotein (apo) distribution and lipoprotein (Lp)-associated markers of @entity32 , such as @entity6511 ( @entity6511 ), influence the atherogenicity of circulating lipids and lipoproteins. Little evidence exists regarding the dose-response effects of the marine @entity9539 @entity7784 ( @entity8393 ) and @entity4600 ( @entity4601 ) on apos, apo-defined Lps, and @entity6511 . OBJECTIVE: The purpose of this study was to compare the effects of 0, 0.85, and 3.4  g/d of @entity8393  +  @entity4601 on @entity6511 mass and activity in individuals with moderate @entity2298 . We also measured effects on concentrations of apoAI, @entity3294 , @entity755 , apoC, @entity16990 , and @entity2204 -defined Lp subclasses. METHODS: The study was a randomized, doubleblind, crossover design with 8-week treatment periods and 6-week washout periods. During the 3 treatment periods, subjects (n  =  25) received 0  g/d @entity8393  +  @entity4601 , 0.85  g/d @entity8393  +  @entity4601 (low dose), and 3.4  g/d @entity8393  +  @entity4601 (high dose) in random order. RESULTS: @entity755 and @entity12436 were significantly decreased by the high dose relative to placebo and low dose (P  <  .01), as was very low-density lipoprotein @entity165 (P  <  .005). The low dose had no effect on Lp outcomes compared with placebo. The high- and low-dose effects differed significantly for heparin-precipitated @entity12436 , LpB, LpA-I, and @entity755 / @entity1675 ratio (P  <  .05). There was a trend for a decreased @entity6511 mass with the high dose (P  =  .1). CONCLUSION: The effects of 3.4  g/d @entity8393  +  @entity4601 on @entity755 and @entity12436 may reduce @entity731 in individuals with elevated @entity1674 .

title: Dose-response effects of marine @entity9539 on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and XXXX in individuals with moderate @entity2298 .

answer: @entity6511 :: (7941,Gene) :: ['Lp-PLA2']


abstract: BACKGROUND: Apolipoprotein (apo) distribution and lipoprotein (Lp)-associated markers of @entity32 , such as @entity6511 ( @entity6511 ), influence the atherogenicity of circulating lipids and lipoproteins. Little evidence exists regarding the dose-response effects of the marine @entity9539 @entity7784 ( @entity8393 ) and @entity4600 ( @entity4601 ) on apos, apo-defined Lps, and @entity6511 . OBJECTIVE: The purpose of this study was to compare the effects of 0, 0.85, and 3.4  g/d of @entity8393  +  @entity4601 on @entity6511 mass and activity in individuals with moderate @entity2298 . We also measured effects on concentrations of apoAI, @entity3294 , @entity755 , apoC, @entity16990 , and @entity2204 -defined Lp subclasses. METHODS: The study was a randomized, doubleblind, crossover design with 8-week treatment periods and 6-week washout periods. During the 3 treatment periods, subjects (n  =  25) received 0  g/d @entity8393  +  @entity4601 , 0.85  g/d @entity8393  +  @entity4601 (low dose), and 3.4  g/d @entity8393  +  @entity4601 (high dose) in random order. RESULTS: @entity755 and @entity12436 were significantly decreased by the high dose relative to placebo and low dose (P  <  .01), as was very low-density lipoprotein @entity165 (P  <  .005). The low dose had no effect on Lp outcomes compared with placebo. The high- and low-dose effects differed significantly for heparin-precipitated @entity12436 , LpB, LpA-I, and @entity755 / @entity1675 ratio (P  <  .05). There was a trend for a decreased @entity6511 mass with the high dose (P  =  .1). CONCLUSION: The effects of 3.4  g/d @entity8393  +  @entity4601 on @entity755 and @entity12436 may reduce @entity731 in individuals with elevated @entity1674 .

title: Dose-response effects of marine @entity9539 on apolipoproteins, apolipoprotein-defined lipoprotein subclasses, and @entity6511 in individuals with moderate XXXX .

answer: @entity2298 :: (MESH:D015228,Disease) :: ['hypertriglyceridemia']


abstract: BACKGROUND: At a time of increasing high risk neonates, an assessment method is needed that can reliably predict @entity51 at an early age. AIMS: The objective of this study was to determine whether the assessment of @entity717 ( @entity717 ) will predict the neurological outcome of @entity1 with @entity2806 ( @entity2806 ). STUDY DESIGN: This study employed a prospective and descriptive plan. SUBJECTS: The study sample consisted of 15 @entity1 (8 male and 7 female) born at term. Video recording of @entity717 were analyzed at 3 to 5months' @entity1 , who identified with perinatal @entity1763 and neonatal @entity2806 . @entity717 were classified as present or absent. OUTCOME MEASURES: At 12-18months age, the @entity1 ' developmental outcome was classified as normal or abnormal according to the @entity1 Neurological International Battery test. "Abnormal outcome" was denoted as poor motor or neurological outcome such as @entity306 , whereas "Normal outcome" denotes normal motor and neurological outcomes. RESULTS: The predictive values of @entity717 were: a sensitivity 0.80 (95% CI: 0.44-0.96), a specificity 1.00 (95% CI: 0.47-1.00), and the accuracy 0.87 (0.57 to 1.00). CONCLUSIONS: @entity717 assessment improves our ability to predict later neurodevelopmental outcomes in term born @entity1 with neonatal @entity2806 .

title: General movements as a predictive tool of the neurological outcome in term born @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Infant', 'infants']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic ischemic encephalopathy', 'HIE']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['FMs', 'fidgety movements']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['hypoxic ischemic encephalopathy']


abstract: BACKGROUND: At a time of increasing high risk neonates, an assessment method is needed that can reliably predict @entity51 at an early age. AIMS: The objective of this study was to determine whether the assessment of @entity717 ( @entity717 ) will predict the neurological outcome of @entity1 with @entity2806 ( @entity2806 ). STUDY DESIGN: This study employed a prospective and descriptive plan. SUBJECTS: The study sample consisted of 15 @entity1 (8 male and 7 female) born at term. Video recording of @entity717 were analyzed at 3 to 5months' @entity1 , who identified with perinatal @entity1763 and neonatal @entity2806 . @entity717 were classified as present or absent. OUTCOME MEASURES: At 12-18months age, the @entity1 ' developmental outcome was classified as normal or abnormal according to the @entity1 Neurological International Battery test. "Abnormal outcome" was denoted as poor motor or neurological outcome such as @entity306 , whereas "Normal outcome" denotes normal motor and neurological outcomes. RESULTS: The predictive values of @entity717 were: a sensitivity 0.80 (95% CI: 0.44-0.96), a specificity 1.00 (95% CI: 0.47-1.00), and the accuracy 0.87 (0.57 to 1.00). CONCLUSIONS: @entity717 assessment improves our ability to predict later neurodevelopmental outcomes in term born @entity1 with neonatal @entity2806 .

title: General movements as a predictive tool of the neurological outcome in term born XXXX with @entity2806 .

answer: @entity1 :: (9606,Species) :: ['infants']


abstract: UNASSIGNED: This article reports a taxonomic classification of rare @entity1141 based on metabolic phenotypes. It was prepared by The Skeletal Rare Diseases Working Group of the International @entity170 Foundation (IOF) and includes 116 OMIM phenotypes with 86 affected genes. INTRODUCTION: Rare skeletal metabolic diseases comprise a group of diseases commonly associated with severe clinical consequences. In recent years, the description of the clinical phenotypes and radiographic features of several genetic @entity79 was paralleled by the discovery of key molecular pathways involved in the regulation of bone and mineral metabolism. Including this information in the description and classification of rare @entity1141 may improve the recognition and management of affected @entity1 . METHODS: IOF recognized this need and formed a Skeletal Rare Diseases Working Group (SRD-WG) of basic and clinical scientists who developed a taxonomy of rare @entity1141 based on their metabolic pathogenesis. RESULTS: This taxonomy of @entity74 ( @entity74 ) comprises 116 OMIM phenotypes, with 86 affected genes related to bone and mineral homeostasis. The diseases were divided into four major groups, namely, disorders due to altered osteoclast, osteoblast, or osteocyte activity; disorders due to altered bone matrix proteins; disorders due to altered bone microenvironmental regulators; and disorders due to deranged calciotropic hormonal activity. CONCLUSIONS: This article provides the first comprehensive taxonomy of rare metabolic @entity1141 based on deranged metabolic activity. This classification will help in the development of common and shared diagnostic and therapeutic pathways for these @entity1 and also in the creation of international registries of rare @entity1141 , the first step for the development of genetic tests based on next generation sequencing and for performing large intervention trials to assess efficacy of orphan drugs.

title: Taxonomy of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['Osteoporosis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone disorders']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['rare genetic metabolic bone disorders', 'RGMBDs']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['skeletal diseases']

answer: @entity74 :: (MESH:D030342,Disease) :: ['rare genetic metabolic bone disorders']


abstract: The association of @entity1985 ( @entity1985 ) with @entity4434 is uncommon. The authors report on 9 pediatric cases (6 @entity1 and 3 @entity1 ). All the @entity1 (age 12 to 48 months) presented initially with a pure @entity1985 . The syndrome was clinically severe and either initially or secondarily resistant to @entity134 and immunosuppressive therapy. In 6 cases initial renal biopsies showed @entity8 and in one case, segmental and focal hyalinization was observed. Symptoms of tubular insufficiency appeared progressively and included: proximal and distal @entity520 (9/9 cases), renal @entity10200 (9/9 cases), @entity1371 with hyperkaluria (7/9 cases), hypohposphatemia (4/9 cases), global hyperaminoaciduria (4/9 cases), tubular proteinura (2/9 cases). Control of water and electrolyte balance was difficult. The urinary concentration of @entity2002 breakdown products was very high throughout the course of the disease. In all cases, @entity417 preceded the inevitable alteration of glomerular filtration which resulted in four cases of @entity177 after an average evolution of 2 to 3 years. Renal biopsies during the later stages of evolution demonstrated five cases of @entity8 with @entity82 associated in 3 cases with histiocytic infiltration. Immunologic studies were negative. The authors discuss the physiopathologic aspects of the disease including the possibility of @entity715 of intrarenal veins and compare their observations with those of Royer et al. [1963].

title: Severe idiopathic nephrotic syndrome with XXXX (report of nine pediatric cases).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'girls', 'boys']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['minimal glomerular lesions', 'glomerular hyalinization']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['terminal renal failure']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['hyperchloremic acidosis']

entities_list: @entity10200 :: ('MESH:D006029', 'Disease') :: ['glycosuria']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['idopathic nephrotic syndrome', 'INS']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity4434 :: ('MESH:D005198', 'Disease') :: ['tubular dysfunction']

entities_list: @entity1371 :: ('MESH:D007008', 'Disease') :: ['hypokalemia']

answer: @entity4434 :: (MESH:D005198,Disease) :: ['tubular dysfunction']


abstract: PURPOSE: To determine whether the presence of intervertebral bridging ossifications is associated with intravertebral cleft (IVC) formation following a @entity3814 ( @entity3814 ). METHODS: @entity1 with a @entity3814 who received conservative treatment for a minimum of 3  months were recruited over a 3-year period. Baseline radiographs obtained within a month of onset were compared between 50 @entity1 who developed an IVC at 3-month follow-up (IVC group) and 100 @entity1 without an IVC (control group). Intervertebral bridging ossification was defined as complete bridging of the intervertebral space by ossification. The presence of bridging ossification was assessed at each intervertebral level from T9/10 to L5/S. In addition to the absolute levels of bridging ossifications, the level relative to a fresh @entity3814 was recorded. RESULT: The incidence of bridging ossification at levels T9/10 and @entity3138 was significantly higher in the IVC group than in the control group. IVC group @entity1 showed a significantly higher incidence of bridging ossification at the second proximal intervertebral segment than those in the control group. IVC group @entity1 also had a significantly greater sagittal wedge angle and a greater local kyphosis angle than control group @entity1 . CONCLUSION: A fresh @entity3814 with bridging ossification at the second proximal intervertebral level is associated with increased risk of IVC formation. Careful observation and strict conservative treatment are recommended in such cases.

title: Intervertebral bridging ossifications increase the risk of intravertebral cleft formation following a XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3814 :: ('MESH:D050815', 'Disease') :: ['VCF', 'vertebral compression fracture']

answer: @entity3814 :: (MESH:D050815,Disease) :: ['vertebral compression fracture']


abstract: The changes in cell surface properties of Rahnella sp. strain @entity66282 and modifications in genetic material after long-term contact with @entity3857 and rhamnolipids, were investigated. Rhamnolipids caused a decrease of hydrophobicity in liquid cultures compared with @entity3857 . On the other hand, in cultures with rhamnolipids, the addition of diesel oil results in a rapid rise of cell surface hydrophobicity. The similar effect was not so significant in the presence of @entity3857 . For the bacteria grown in the presence of @entity3857 or rhamnolipids, but without diesel oil, the ratio of unsaturated to @entity1718 decreased, in comparison to the control culture. The differences observed in hydrophobicity, zeta potential and @entity1718 profiles, indicated various mechanisms of an interaction between a surfactant and a bacterial cells. The results have also shown an impact of the long-term contact on changes in genetic material of Rahnella sp. strain @entity66282 cells. Moreover, the presence of @entity3857 led to significant increase of diesel oil biodegradation.

title: Rahnella sp. strain XXXX : Cell surface properties and diesel oil biodegradation after long-term contact with natural surfactants and diesel oil.

entities_list: @entity3857 :: ('MESH:D012503', 'Chemical') :: ['saponins']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids', 'saturated fatty acids']

answer: @entity66282 :: (285220,Gene) :: ['EK12']


abstract: After the introduction of modern artificial joints the classical operation methods, such as osteotomies, arthrodeses and auto-arthroplasties, have been forced aside little by little. Irrespective of the late complications following replacement surgery, the @entity1 today expect a movable, painless endoprosthesis, which at it best seems to benefit the @entity1 . The question arises whether the classical methods still have a role in the surgical treatment of @entity309 . The reply is "yes", they do have a fair share of rheumatoid surgery, indeed. They still compete with the modern endoprosthetic surgery for the place of the primary operation in many cases. To give instances, tarsal reconstruction by subtaloid arthrodesis is superior to other methods and arthrodesis of the wrist is often only reasonable way to get a strong, painless key joint to the hand. Even the shoulder arthrodesis may successfully compete with an endoprosthesis. Also classical auto-arthroplasties such as resection arthroplasties of the metacarpophalangeal and @entity2720 are serious rivals of respective endoprostheses. The practice of @entity627 Foundation Hospital (RFH) in the golden mean between the endoprosthesis enthusiasts and their opponents will be described in this article. The practice varies greatly from clinic to clinic and is progressing--and regressing--all the time.

title: The role of non-prosthetic surgery in the treatment of @entity309 by fusions and auto-arthroplasties. Current practice at the XXXX Foundation Hospital, Heinola.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['elbow joints']

entities_list: @entity627 :: ('MESH:D012216', 'Disease') :: ['Rheumatism']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

answer: @entity627 :: (MESH:D012216,Disease) :: ['Rheumatism']


abstract: After the introduction of modern artificial joints the classical operation methods, such as osteotomies, arthrodeses and auto-arthroplasties, have been forced aside little by little. Irrespective of the late complications following replacement surgery, the @entity1 today expect a movable, painless endoprosthesis, which at it best seems to benefit the @entity1 . The question arises whether the classical methods still have a role in the surgical treatment of @entity309 . The reply is "yes", they do have a fair share of rheumatoid surgery, indeed. They still compete with the modern endoprosthetic surgery for the place of the primary operation in many cases. To give instances, tarsal reconstruction by subtaloid arthrodesis is superior to other methods and arthrodesis of the wrist is often only reasonable way to get a strong, painless key joint to the hand. Even the shoulder arthrodesis may successfully compete with an endoprosthesis. Also classical auto-arthroplasties such as resection arthroplasties of the metacarpophalangeal and @entity2720 are serious rivals of respective endoprostheses. The practice of @entity627 Foundation Hospital (RFH) in the golden mean between the endoprosthesis enthusiasts and their opponents will be described in this article. The practice varies greatly from clinic to clinic and is progressing--and regressing--all the time.

title: The role of non-prosthetic surgery in the treatment of XXXX by fusions and auto-arthroplasties. Current practice at the @entity627 Foundation Hospital, Heinola.

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: BACKGROUND: @entity1911 (PHEO) is more frequently found in @entity1 with @entity3018 2A carrying a @entity8958 germline mutation located in codon 634 (C634). However, it is unclear whether different @entity3689 substitutions within C634 cause differences in bilateral PHEOs expression. We aimed to answer this by pooling data from two Asian institutions. METHODS: Sixty-seven @entity1 had confirmed C634 germline mutation. Age-dependent penetrance of bilateral PHEO was calculated from date of birth to the date when bilateral PHEO was first diagnosed or when the contralateral gland became a PHEO (if the @entity1 already had one adrenal gland removed). Age-dependent penetrance was estimated by the Kaplan-Meier method and compared by log-rank test. RESULTS: The 4 different @entity3689 substitutions included @entity38738 ( @entity369 ) (n  =  19, 28.4  %), @entity62284 ( @entity4149 ) (n  =  36, 38.8  %), @entity66946 ( @entity8959 ) (n  =  4, 6.0  %), and C634W ( @entity6635 ) (n  =  8, 11.9  %). The age-related penetrance of PHEO was similar between @entity38738 , @entity62284 , @entity66946 , and C634W (by age 40, 69.8, 55.2, 25.0, and 56.2  %, respectively) (p  =  0.529). However, the age-related penetrance of bilateral PHEO in @entity38738 was significantly higher than @entity62284 (by age of 40, 59.3  % vs. 25.2  %, p  =  0.046) or @entity62284 , @entity66946 , and C634W combined (59.3  % vs. 21.5  %, p  =  0.024). Nevertheless, the accumulative risk of bilateral PHEOs across all four C634 mutations almost approached 100  % over time. CONCLUSION: The accumulative risk of bilateral PHEOs almost reached 100  % but its onset was significantly earlier in @entity38738 mutation. These findings implied that those with @entity38738 mutation might benefit from earlier screening of contralateral PHEO than other C634 mutations after an unilateral adrenalectomy.

title: @entity1911 in XXXX Syndrome: A Two-Institution Experience.

entities_list: @entity3018 :: ('MESH:D009377', 'Disease') :: ['multiple endocrine neoplasia']

entities_list: @entity1911 :: ('MESH:D010673', 'Disease') :: ['Bilateral pheochromocytoma']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity8958 :: (5979,Gene) :: ['MEN2A']


abstract: BACKGROUND: @entity1911 (PHEO) is more frequently found in @entity1 with @entity3018 2A carrying a @entity8958 germline mutation located in codon 634 (C634). However, it is unclear whether different @entity3689 substitutions within C634 cause differences in bilateral PHEOs expression. We aimed to answer this by pooling data from two Asian institutions. METHODS: Sixty-seven @entity1 had confirmed C634 germline mutation. Age-dependent penetrance of bilateral PHEO was calculated from date of birth to the date when bilateral PHEO was first diagnosed or when the contralateral gland became a PHEO (if the @entity1 already had one adrenal gland removed). Age-dependent penetrance was estimated by the Kaplan-Meier method and compared by log-rank test. RESULTS: The 4 different @entity3689 substitutions included @entity38738 ( @entity369 ) (n  =  19, 28.4  %), @entity62284 ( @entity4149 ) (n  =  36, 38.8  %), @entity66946 ( @entity8959 ) (n  =  4, 6.0  %), and C634W ( @entity6635 ) (n  =  8, 11.9  %). The age-related penetrance of PHEO was similar between @entity38738 , @entity62284 , @entity66946 , and C634W (by age 40, 69.8, 55.2, 25.0, and 56.2  %, respectively) (p  =  0.529). However, the age-related penetrance of bilateral PHEO in @entity38738 was significantly higher than @entity62284 (by age of 40, 59.3  % vs. 25.2  %, p  =  0.046) or @entity62284 , @entity66946 , and C634W combined (59.3  % vs. 21.5  %, p  =  0.024). Nevertheless, the accumulative risk of bilateral PHEOs across all four C634 mutations almost approached 100  % over time. CONCLUSION: The accumulative risk of bilateral PHEOs almost reached 100  % but its onset was significantly earlier in @entity38738 mutation. These findings implied that those with @entity38738 mutation might benefit from earlier screening of contralateral PHEO than other C634 mutations after an unilateral adrenalectomy.

title: XXXX in @entity8958 Syndrome: A Two-Institution Experience.

answer: @entity1911 :: (MESH:D010673,Disease) :: ['Bilateral Pheochromocytomas']


abstract: BACKGROUND: An elevated risk of @entity1 /visitor perpetrated violence (type II) against hospital nurses and physicians have been reported, while little is known about @entity1605 among other hospital workers, and circumstances surrounding these events. METHODS: Hospital workers (n   =   11,000) in different geographic areas were invited to participate in an anonymous survey. RESULTS: Twelve-month prevalence of @entity1605 was 39%; 2,098 of 5,385 workers experienced 1,180 physical assaults, 2,260 physical threats, and 5,576 incidents of @entity734 . Direct care providers were at significant risk, as well as some workers that do not provide direct care. Perpetrator circumstances attributed to violent events included altered @entity1032 , behavioral issues, @entity158 /medication withdrawal, dissatisfaction with care. Fear for safety was common among worker victims (38%). Only 19% of events were reported into official reporting systems. CONCLUSIONS: This pervasive occupational safety issue is of great concern and likely extends to @entity1 for whom these workers care for. Am. J. Ind. Med.    2015 Wiley Periodicals, Inc.

title: Physical assault, physical threat, and XXXX perpetrated against hospital workers by @entity1 or visitors in six U.S. hospitals.

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental status']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['type II violence']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['verbal abuse']

answer: @entity734 :: (MESH:D019966,Disease) :: ['verbal abuse']


abstract: BACKGROUND: An elevated risk of @entity1 /visitor perpetrated violence (type II) against hospital nurses and physicians have been reported, while little is known about @entity1605 among other hospital workers, and circumstances surrounding these events. METHODS: Hospital workers (n   =   11,000) in different geographic areas were invited to participate in an anonymous survey. RESULTS: Twelve-month prevalence of @entity1605 was 39%; 2,098 of 5,385 workers experienced 1,180 physical assaults, 2,260 physical threats, and 5,576 incidents of @entity734 . Direct care providers were at significant risk, as well as some workers that do not provide direct care. Perpetrator circumstances attributed to violent events included altered @entity1032 , behavioral issues, @entity158 /medication withdrawal, dissatisfaction with care. Fear for safety was common among worker victims (38%). Only 19% of events were reported into official reporting systems. CONCLUSIONS: This pervasive occupational safety issue is of great concern and likely extends to @entity1 for whom these workers care for. Am. J. Ind. Med.    2015 Wiley Periodicals, Inc.

title: Physical assault, physical threat, and @entity734 perpetrated against hospital workers by XXXX or visitors in six U.S. hospitals.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION: Targeted spinal @entity479 injections are effective in @entity615 in selected @entity1 populations and carry a small risk of significant adverse neurological outcomes. Recent recommendations are for the use of non-particulate @entity479 agents for all spinal injections to reduce the risk of @entity531 adverse events. Many injections have used a combination of local anaesthetic agent with the @entity479 . At our institutions, we have recently observed interactions between @entity1342 and @entity619 combinations ascribed to the incompatibility of the former with alkaline solutions, resulting in rapid crystallisation. This study has further investigated the combinations of commonly used local anaesthetic and @entity479 combinations to determine if such precipitation effects are more widespread. METHODS: The commonly used local anaesthetics ( @entity3303 , @entity1341 , @entity1342 ) and the non-particulate @entity479 @entity619 @entity10457 combinations were evaluated macroscopically, microscopically, and pH values measured. Where crystallisation was observed the rate of precipitation and crystal size was measured. Contamination of @entity1342 with @entity4388 solution was also evaluated. Particulate size of the particulate @entity479 agent @entity43756 was evaluated as a comparison. RESULTS: All mixtures of @entity1342 and the non-particulate @entity619 @entity10457 assessed demonstrated a pH-dependent crystallisation of the solution. No precipitation was demonstrated with the combinations of @entity619 and @entity3303 or @entity1341 . Contamination of @entity1342 with residual @entity4388 in a drawing up needle following air clearing had a precipitation effect. CONCLUSION: We describe the effect of crystallisation with the combination of @entity1342 and the non-particulate @entity479 , @entity21025 , a mixture that has been used in the literature for targeted @entity158 injections. As this may be considered a non-particulate @entity479 /anaesthetic injectate, this would potentially carry increased risk if inadvertent intravascular injection occurred during a targeted spinal injection, as has been described with particulate @entity479 agents. This is due to the elevated pH of @entity619 and the incompatibility of @entity1342 with alkaline solutions.

title: @entity1342 and XXXX : a potentially dangerous combination for therapeutic @entity158 injections.

entities_list: @entity21025 :: ('MESH:C004180', 'Chemical') :: ['dexamethasone sodium phosphate']

entities_list: @entity4388 :: ('MESH:D017693', 'Chemical') :: ['sodium bicarbonate']

entities_list: @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['reducing back pain']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lignocaine']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity43756 :: ('CHEBI:31275', 'Chemical') :: ['betamethasone acetate']

entities_list: @entity10457 :: ('MESH:C018279', 'Chemical') :: ['sodium phosphate']

entities_list: @entity531 :: ('MESH:D013901', 'Disease') :: ['neurovascular embolic']

answer: @entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']


abstract: INTRODUCTION: Targeted spinal @entity479 injections are effective in @entity615 in selected @entity1 populations and carry a small risk of significant adverse neurological outcomes. Recent recommendations are for the use of non-particulate @entity479 agents for all spinal injections to reduce the risk of @entity531 adverse events. Many injections have used a combination of local anaesthetic agent with the @entity479 . At our institutions, we have recently observed interactions between @entity1342 and @entity619 combinations ascribed to the incompatibility of the former with alkaline solutions, resulting in rapid crystallisation. This study has further investigated the combinations of commonly used local anaesthetic and @entity479 combinations to determine if such precipitation effects are more widespread. METHODS: The commonly used local anaesthetics ( @entity3303 , @entity1341 , @entity1342 ) and the non-particulate @entity479 @entity619 @entity10457 combinations were evaluated macroscopically, microscopically, and pH values measured. Where crystallisation was observed the rate of precipitation and crystal size was measured. Contamination of @entity1342 with @entity4388 solution was also evaluated. Particulate size of the particulate @entity479 agent @entity43756 was evaluated as a comparison. RESULTS: All mixtures of @entity1342 and the non-particulate @entity619 @entity10457 assessed demonstrated a pH-dependent crystallisation of the solution. No precipitation was demonstrated with the combinations of @entity619 and @entity3303 or @entity1341 . Contamination of @entity1342 with residual @entity4388 in a drawing up needle following air clearing had a precipitation effect. CONCLUSION: We describe the effect of crystallisation with the combination of @entity1342 and the non-particulate @entity479 , @entity21025 , a mixture that has been used in the literature for targeted @entity158 injections. As this may be considered a non-particulate @entity479 /anaesthetic injectate, this would potentially carry increased risk if inadvertent intravascular injection occurred during a targeted spinal injection, as has been described with particulate @entity479 agents. This is due to the elevated pH of @entity619 and the incompatibility of @entity1342 with alkaline solutions.

title: XXXX and @entity619 : a potentially dangerous combination for therapeutic @entity158 injections.

answer: @entity1342 :: (MESH:C037663,Chemical) :: ['Ropivacaine']


abstract: INTRODUCTION: Targeted spinal @entity479 injections are effective in @entity615 in selected @entity1 populations and carry a small risk of significant adverse neurological outcomes. Recent recommendations are for the use of non-particulate @entity479 agents for all spinal injections to reduce the risk of @entity531 adverse events. Many injections have used a combination of local anaesthetic agent with the @entity479 . At our institutions, we have recently observed interactions between @entity1342 and @entity619 combinations ascribed to the incompatibility of the former with alkaline solutions, resulting in rapid crystallisation. This study has further investigated the combinations of commonly used local anaesthetic and @entity479 combinations to determine if such precipitation effects are more widespread. METHODS: The commonly used local anaesthetics ( @entity3303 , @entity1341 , @entity1342 ) and the non-particulate @entity479 @entity619 @entity10457 combinations were evaluated macroscopically, microscopically, and pH values measured. Where crystallisation was observed the rate of precipitation and crystal size was measured. Contamination of @entity1342 with @entity4388 solution was also evaluated. Particulate size of the particulate @entity479 agent @entity43756 was evaluated as a comparison. RESULTS: All mixtures of @entity1342 and the non-particulate @entity619 @entity10457 assessed demonstrated a pH-dependent crystallisation of the solution. No precipitation was demonstrated with the combinations of @entity619 and @entity3303 or @entity1341 . Contamination of @entity1342 with residual @entity4388 in a drawing up needle following air clearing had a precipitation effect. CONCLUSION: We describe the effect of crystallisation with the combination of @entity1342 and the non-particulate @entity479 , @entity21025 , a mixture that has been used in the literature for targeted @entity158 injections. As this may be considered a non-particulate @entity479 /anaesthetic injectate, this would potentially carry increased risk if inadvertent intravascular injection occurred during a targeted spinal injection, as has been described with particulate @entity479 agents. This is due to the elevated pH of @entity619 and the incompatibility of @entity1342 with alkaline solutions.

title: @entity1342 and @entity619 : a potentially dangerous combination for therapeutic XXXX injections.

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: BACKGROUND: Prophylactic @entity272 ( @entity272 ) and nipple-sparing mastectomy (NSM) both are associated with major risk reduction in @entity1 with high @entity0 risk. Skin-sparing mastectomy followed by nipple-areola complex (NAC) reconstruction is standard of care, but NSM is increasingly being performed. Preservation of the NAC in NSM may increase @entity1 satisfaction. Therefore, we measured NAC sensitivity after NSM and compared @entity1 satisfaction as well as body image after @entity272 with NSM. METHODS: @entity1 who underwent prophylactic bilateral @entity272 or NSM and immediate implant breast reconstruction between 2002 and 2012 were eligible. @entity1 satisfaction was assessed using the Breast-Q reconstruction questionnaire, body image using Hopwood's body image scale (BIS), and satisfaction with the (reconstructed) NAC using a study-specific questionnaire. In the NSM group, NAC sensitivity was assessed using Semmes Weinstein monofilaments with a 5-point scale and compared with NAC sensitivity in a nonoperated control group. RESULTS: The @entity272 group comprised 25 @entity1 (50 SSMs) and the NSM group 20 @entity1 (39 NSMs). Median follow-up was 65 months in the @entity272 group compared with 27 months in the NSM group (P < 0.01). In univariable analyses, Breast-Q scores were favorable in the @entity272 group compared with the NSM group with trends for higher "satisfaction with breasts" (66.2 vs 56.6; P = 0.06) and "satisfaction with outcome" (76.1 vs 61.5; P = 0.09). Mean BIS score of 7.1/30 in the @entity272 group and 9.3/30 in the NSM group (P = 0.35). Adjusted for follow-up, there were no significant differences in Breast-Q scores, nor in BIS scores. Interestingly, satisfaction with the (reconstructed) NAC was similar after @entity272 and NSM. @entity4098 was lower in the NSM group (mean score, 1.9; 95% confidence interval, 1.5-2.3) compared with the control group (mean score, 4.7; 95% confidence interval, 4.6-4.9; P < 0.01). CONCLUSIONS: Breast-Q scores regarding satisfaction with breasts and overall outcome were in favor of the @entity272 group. Residual NAC sensitivity after NSM was low. This suggests that @entity272 followed by NAC reconstruction is a balanced alternative to NSM. We observed no significant differences in body image and NAC-specific satisfaction between the NSM and @entity272 groups.

title: XXXX Satisfaction and Nipple-Areola Sensitivity After Bilateral Prophylactic Mastectomy and Immediate Implant Breast Reconstruction in a High Breast Cancer Risk Population: Nipple-Sparing Mastectomy Versus Skin-Sparing Mastectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient', 'Women', 'Patient']

entities_list: @entity4098 :: ('MESH:D010144', 'Disease') :: ['Nipple-areola complex sensitivity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['SSM', 'skin-sparing mastectomy']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: UNASSIGNED: Assisted reproductive technology (ART) is being increasingly applied to overcome @entity249 . However, the in vitro production process, the main procedure of ART, can lead to aberrant embryonic development and health-related problems in offspring. Understanding the mechanisms underlying the ART-induced side effects is important to improve the ART process. In this study, we carried out comparative transcriptome profiling between in vivo- (IVO) and in vitro- produced (IVP) @entity19 blastocysts. Our results suggested that aberrant actin organization might be a major factor contributing to the impaired development of IVP embryos. To test this, we examined the effect of actin disorganization on the development of IVP preimplantation embryos. Specific disruption of actin organization by @entity2389 (CB) indicated that well-organized actin is essential for in vitro embryonic development. Supplementing the culture medium with 10-9 M @entity2493 , a cytoskeletal modulator in adult somatic cells, significantly reversed the disrupted expression patterns of genes related to actin organization, including @entity52905 , @entity1379 , @entity73069 , @entity18334 , and Palld. Immunofluorescence analysis showed that @entity2493 treatment of IVP embryos significantly improved the distribution and organization of actin filaments (F-actin) from the 8-cell stage onwards. More importantly, we found that @entity2493 alleviated the CB-mediated aberrant F-actin distribution and organization and rescued CB-induced impaired embryonic development. This is the first study to indicate that actin disorganization is implicated in impaired development of IVP embryos during the preimplantation stage. We also demonstrated that improving actin organization is a promising strategy to optimize existing IVP systems.

title: Actin Disorganization Plays a Vital Role in Impaired Embryonic Development of In Vitro-Produced XXXX Preimplantation Embryos.

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity2493 :: ('MESH:D008550', 'Chemical') :: ['melatonin']

entities_list: @entity2389 :: ('MESH:D003571', 'Chemical') :: ['cytochalasin B']

answer: @entity19 :: (10090,Species) :: ['Mouse']


abstract: BACKGROUND: Anesthesia-related medication shortages have become increasingly common in the United States. We tested whether a local shortage of pharmacy-prepared @entity6358 syringes, replaced by provider-prepared @entity6358 , was associated with provider-level changes in @entity6358 and @entity2647 use and @entity1 -level changes in intraoperative hemodynamics. METHODS: Consecutive @entity1 undergoing general and orthopedic surgery at a tertiary care center were included 1 month before and 1 month after the start of the pharmacy-prepared @entity6358 syringe shortage. Lowest mean arterial blood pressure and slowest heart rate were obtained as measures of hemodynamics. Adjusted associations were tested using mixed-effects regression with repeated measures. RESULTS: Three hundred four @entity1 before the shortage and 298 @entity1 after the shortage began were included. The administration of at least 1 bolus of @entity6358 was significantly more common before versus during the shortage (148/304 [48.7]% vs 117/298 [39.3]%; P = 0.0199). After adjusting for age, sex, ASA physical status, surgery type, anesthesia provider, and operative duration, @entity1 were significantly less likely to receive @entity6358 during the shortage (relative risk [RR] = 0.78 [95% confidence interval {CI}, 0.61-0.96]; P = 0.0198) and more likely to receive a @entity2647 bolus (RR = 1.27 [95% CI, 1.02-1.51]; P = 0.0357). @entity1 hemodynamics assessed by slowest heart rate or lowest mean arterial blood pressure did not differ significantly during the shortage. CONCLUSIONS: There was an alteration in medication administration patterns during a shortage of pharmacy-prepared syringes. Changes in @entity6358 and @entity2647 use were noted; however, @entity1 hemodynamics remained comparable. Provider use patterns were sensitive even to a relative and not absolute medication shortage as observed in this study.

title: The Impact of a Shortage of Pharmacy-Prepared XXXX Syringes on Intraoperative Medication Use.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

entities_list: @entity6358 :: ('MESH:D004809', 'Chemical') :: ['ephedrine']

answer: @entity6358 :: (MESH:D004809,Chemical) :: ['Ephedrine']


abstract: A review was undertaken of all @entity1 treated for invasive @entity189 in the Wellington region in the period 1975 to 1979. A total of 84 @entity1 were assessed for the results and complications of treatment. Forty-one were stage I, 18 stage II, 18 stage III, and seven stage IV (FIGO staging). Treatment by different combinations of surgery and radiotherapy for each stage are described. Actuarial survival at five years is 54% for all stages. For stage I it is 86%, stage II 54%, and stage III 44%. There were only seven @entity1 in stage IV. Seven @entity1 (8.3%) suffered major complications, mainly gastrointestinal or genitourinary. Most complications occurred in @entity1 treated with a combination of radical surgery followed by high dose external radiotherapy. This treatment should be reserved for selected @entity1 who can be identified as having a very high risk of recurrence in the pelvis after surgery. Invasive @entity5 is a highly treatable disease, with over half the @entity1 surviving free of disease at five years, but screening programmes for early detection are essential.

title: Results of treatment of XXXX in Wellington: 1975-9.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer of the cervix']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the cervix']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer of the cervix']


abstract: BACKGROUND: The surgical treatment of @entity4553 is connected with significant @entity282 . Spinal and general anesthesia as well as peripheral blocks are successfully used in foot surgery. The purpose of this study was to evaluate the influence of local anesthetic infiltration before @entity4553 one-day surgery on @entity282 and the need for analgesics. MATERIAL AND METHODS: 134 @entity1 underwent chevron or miniinvasive @entity44619 of the first distal metatarsal. After general anesthesia each @entity1 randomly received an infiltration of 7ml of local anesthetic (4 ml of 0.25% @entity1341 and 3 ml of 2% @entity3303 ) or the same amount of normal saline 15 minutes before the skin incision. Both the @entity1 and the surgeon were blinded. The @entity1 was discharged after approximately 2 hours of observation. 2, 4, 8, 12, 16, 24 and 72 hours after the release of the tourniquet the level of @entity158 was assessed by the visual analogue scale (VAS). Rescue @entity1337 , side effects and the use of painkillers were noted. RESULTS: Preemptive local anesthetic infiltration significantly decreased @entity158 during the first 24 hours after the surgery. None of the @entity1 from the injected group and 38 from the placebo group received 100 mg of @entity7988 intravenously for rescue @entity1337 in the first 2 hours after the release of the tourniquet. During the first 24 hours we noted significantly decreased use of 1000 mg of @entity1443 and 100 mg mg of @entity7988 orally in the injected group. No systemic adverse effects were noted. One @entity1 from placebo group had @entity56 rush after use of 100 mg @entity7988 . CONCLUSIONS: Preemptive local anesthetic infiltration in one-day @entity4553 surgery significantly decreases @entity282 . It is safe, efficient and allows fast discharge.

title: [Preemptive local anesthetic infiltration in XXXX one-day surgery].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity7988 :: ('MESH:D007660', 'Chemical') :: ['ketoprofen']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity44619 :: ('MESH:C537866', 'Disease') :: ['Mitchell-Kramer osteotomy']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity4553 :: ('MESH:D006215', 'Disease') :: ['hallux valgus', 'hallux valgus deformity']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic']

entities_list: @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

answer: @entity4553 :: (MESH:D006215,Disease) :: ['hallux valgus']


abstract: UNASSIGNED: Renal resistive index (RRI) measured by Doppler ultrasonography is associated with cardiovascular events and mortality in @entity101 , @entity6 , and elderly @entity1 . We studied the factors associated with high RRI (>= 0.70) and its associations with mortality in @entity740 @entity1 without @entity2791 . We included 1962 @entity1 with an estimated glomerular filtration rate of 15 to 59 mL/min per 1.73 m(2) who also had RRI measured (January 1, 2005, to October 2011) from an existing @entity740 registry. @entity1 with @entity2791 (60%-99% or @entity432 ) were excluded. Multivariable logistic regression model was used to study factors associated with high RRI (>= 0.70), and its association with mortality was studied using Kaplan-Meier plots and Cox proportional hazards model. @entity101 was prevalent in >90% of the @entity1 . In the multivariable logistic regression, older age, female sex, @entity6 , @entity453 , @entity1095 , higher systolic blood pressure, and the use of b blockers were associated with higher odds of having RRI>= 0.70. During a median follow-up of 2.2 years, 428 @entity1 died. After adjusting for covariates, RRI>= 0.70 was associated with increased mortality (adjusted hazard ratio, 1.29; 95% confidence interval, 1.02-1.65; P<0.05). This association was more pronounced among younger @entity1 and those with stage 3 @entity740 . Noncardiovascular/non-malignancy-related @entity204 were higher in those with RRI>= 0.70. RRI>= 0.70 is associated with higher mortality in @entity740 @entity1 without clinically significant @entity2791 after accounting for other significant risk factors. Its evaluation may allow early identification of those who are at risk thereby potentially preventing or delaying adverse outcomes.

title: Renal Resistive Index and Mortality in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Participants']

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive', 'Hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes mellitus']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['renal artery stenosis']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['hypertensive chronic kidney disease', 'chronic kidney disease']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['renal artery occlusion']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity740 :: (MESH:D051436,Disease) :: ['Chronic Kidney Disease']


abstract: PURPOSE: To determine whether the structure-function relationship in @entity726 can be strengthened by using more precise structural and functional measurements combined with individualized structure-function maps and custom sector selection on the optic nerve head (ONH). DESIGN: Cross-sectional study. @entity1 : One eye of each of 23 @entity1 with @entity726 . METHODS: @entity1 were tested twice. Visual fields were collected on a high-resolution 3   * 3   grid (164 locations) using a Zippy Estimation by Sequential Testing test procedure with uniform prior probability to improve the accuracy and precision of scotoma characterization relative to standard methods. Retinal nerve fiber layer (RNFL) thickness was measured using spectral-domain optical coherence tomography (OCT; 4 scans, 2 per visit) with manual removal of blood vessels. Individualized maps, based on biometric data, were used. To customize the areas of the ONH and visual field to correlate, we chose a 30   sector centered on the largest defect shown by OCT and chose @entity227 using the individualized maps. Baseline structure-function correlations were calculated between 24-2 locations (n = 52) of the first tested visual field and RNFL thickness from 1 OCT scan, using the sectors of the Garway-Heath map. We added additional data (averaged visual field and OCT, additional 106 @entity227 and OCT without blood vessels, individualized map, and customized sector) and recomputed the correlations. MAIN OUTCOME MEASURES: Spearman correlation between structure and function. RESULTS: The highest baseline correlation was 0.52 (95% confidence interval [CI], 0.13-0.78) in the superior temporal ONH sector. Improved measurements increased the correlation marginally to 0.58 (95% CI, 0.21-0.81). Applying the individualized map to the large, predefined ONH sectors did not improve the correlation; however, using the individualized map with the single 30   ONH sector resulted in a large increase in correlation to 0.77 (95% CI, 0.47-0.92). CONCLUSIONS: Using more precise visual field and OCT measurements did not improve structure-function correlation in our cohort, but customizing the ONH sector and its associated visual field points substantially improved correlation. We suggest using customized ONH sectors mapped to individually relevant @entity227 to unmask localized structural and functional loss.

title: Enhancing Structure-Function Correlations in XXXX with Customized Spatial Mapping.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'PARTICIPANTS']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field locations']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

answer: @entity726 :: (MESH:D005901,Disease) :: ['Glaucoma']


abstract: UNASSIGNED: Preclinical Research @entity1 with @entity158 often display @entity73 including @entity71 . The visual-signal detection task (VSDT) is a behavioral procedure for assessment of attention in rodents. Male @entity35 were trained in a VSDT and tested with three different noxious stimuli: (i) intraperitoneal injection of @entity880 ; (ii) intraplantar injection of @entity406 ; and (iii) intraplantar injection of complete Freund's adjuvant ( @entity3795 ). The muscarinic @entity934 receptor antagonist, @entity5591 was also tested as a positive control. @entity5591 (0.01-1.0 mg/kg) dose dependently reduced accuracy and increased response latencies during completed trials with higher @entity5591 doses increasing omissions. @entity880 (0.56-5.6% ip) also increased response latencies and omissions, although it failed to alter measures of response accuracy. @entity406 produced a transient decrease in accuracy while also increasing both response latency and omissions. @entity3795 failed to alter VSDT performance. Although VSDT effects were transient for @entity406 and absent for @entity3795 , both treatments produced mechanical @entity1931 and paw @entity4 for up to 7 days. These results support the potential for noxious stimuli to produce a @entity158 -related disruption of attention in @entity35 . However, relatively strong noxious stimulation appears necessary to disrupt performance in this version of the VSDT. Drug Dev Res, 2015.    2015 Wiley Periodicals, Inc.

title: Effects of Acute and Sustained XXXX Manipulations on Performance in a Visual-Signal Detection Task of Attention in @entity35 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['deficits in attention']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin', 'Formalin']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid', 'Lactic acid']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague Dawley rats', 'rats']

entities_list: @entity5591 :: ('MESH:D012601', 'Chemical') :: ['Scopolamine', 'scopolamine']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: UNASSIGNED: Preclinical Research @entity1 with @entity158 often display @entity73 including @entity71 . The visual-signal detection task (VSDT) is a behavioral procedure for assessment of attention in rodents. Male @entity35 were trained in a VSDT and tested with three different noxious stimuli: (i) intraperitoneal injection of @entity880 ; (ii) intraplantar injection of @entity406 ; and (iii) intraplantar injection of complete Freund's adjuvant ( @entity3795 ). The muscarinic @entity934 receptor antagonist, @entity5591 was also tested as a positive control. @entity5591 (0.01-1.0 mg/kg) dose dependently reduced accuracy and increased response latencies during completed trials with higher @entity5591 doses increasing omissions. @entity880 (0.56-5.6% ip) also increased response latencies and omissions, although it failed to alter measures of response accuracy. @entity406 produced a transient decrease in accuracy while also increasing both response latency and omissions. @entity3795 failed to alter VSDT performance. Although VSDT effects were transient for @entity406 and absent for @entity3795 , both treatments produced mechanical @entity1931 and paw @entity4 for up to 7 days. These results support the potential for noxious stimuli to produce a @entity158 -related disruption of attention in @entity35 . However, relatively strong noxious stimulation appears necessary to disrupt performance in this version of the VSDT. Drug Dev Res, 2015.    2015 Wiley Periodicals, Inc.

title: Effects of Acute and Sustained @entity158 Manipulations on Performance in a Visual-Signal Detection Task of Attention in XXXX .

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: UNASSIGNED: @entity10057 is a promising platform for single cell oil production. It is well-known for its metabolism oriented toward utilization of hydrophobic substrates and accumulation of storage lipids. Multiple copies of DGA2 under constitutive promoter were introduced into the Q4 strain, a quadruple mutant deleted for the four acyltransferases (  dga1,   dga2,   lro1, and   are1) to improve lipid accumulation. The Q4-DGA2 x3 strain contains three copies of DGA2. Further increase in accumulation was accomplished by blocking the b-oxidation pathway through MFE1 gene deletion yielding Q4-  mfe DGA2 x3. In order to use molasses as a substrate for single cell oil production, @entity969 utilization was established by expressing the @entity375 @entity11609 gene yielding Q4- @entity11609 DGA2 x3 and Q4-  mfe @entity11609 DGA2 x3. During cultivation on @entity969 medium with a @entity505 to @entity1568 ratio of 80, both strains accumulated more than 40  % of lipids, which was a 2-fold increase in lipid storage. Q4-  mfe @entity11609 DGA2 x3 accumulated more lipids than Q4- @entity11609 DGA2 x3 (49 vs. 43  %) but yielded less biomass (13.7 vs. 15  g/L). When grown on 8  % (v/v) molasses, both strains accumulated more than 30  % of lipids after 3  days, while biomass yield was higher in Q4- @entity11609 DGA2 x3 (16.4 vs. 14.4  g/L). Further addition of molasses at 72  h resulted in higher biomass yield, 26.6  g/L for Q4- @entity11609 DGA2 x3, without modification of lipid content. This work presents genetically modified strains of @entity10057 as suitable tools for direct conversion of industrial molasses into value added products based on single cell oils.

title: Single cell oil production on molasses by XXXX strains overexpressing DGA2 in multicopy.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']

entities_list: @entity10057 :: ('4952', 'Species') :: ['Yarrowia lipolytica', 'Y. lipolytica']

answer: @entity10057 :: (4952,Species) :: ['Yarrowia lipolytica']