abstract: UNASSIGNED: @entity1643 ( @entity1643 ) is a public health problem and older @entity1 have higher incidence of this symptom, which affect body balance, functional capacity and behavior. The purpose of this study was to verifying the effect of exercises with Nintendo Wii on @entity1643 , functional capacity and mood of elderly. Thirty older @entity1 (68    4 years; 68    12 kg; 154    5 cm) with @entity1643 participated in this study. Elderly individuals were divided into a Control Exercise Group (n = 14) and an Experimental Wii Group (n = 16). Control Exercise Group did strength exercises and core training, while Experimental Wii Group did ones additionally to exercises with Wii. @entity1643 , balance, functional capacity and mood were assessed pre and post training by the numeric @entity158 scale, Wii Balance Board, sit to stand test and Profile of Mood States, respectively. Training lasted eight weeks and sessions were performed three times weekly. MANOVA 2 x 2 showed no interaction on @entity158 , siting, stand-up and mood (P = 0.53). However, there was significant difference within groups (P = 0.0001). ANOVA 2 x 2 showed no interaction for each variable (P > 0.05). However, there were significant differences within groups in these variables (P < 0.05). Tukey's post-hoc test showed significant difference in @entity158 on both groups (P = 0.0001). Wilcoxon and Mann-Whitney tests identified no significant differences on balance (P > 0.01). Capacity to Sit improved only in Experimental Wii Group (P = 0.04). In conclusion, physical exercises with Nintendo Wii Fit Plus additional to strength and core training were effective only for sitting capacity, but effect size was small.

title: Wii-Workouts on chronic pain, physical capabilities and mood of older XXXX : A randomized controlled double blind trial.

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['Chronic Low Back Pain', 'CLBP']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: @entity71623 (AM) is an @entity71624 compound isolated from honey medicinal mushroom, Armillaria mellea, which has anti- @entity5 potential. This study was designed to examine the effects of AM on differentiation and activation macrophages, the major ontogeny of innate immunity. Macrophages were derived from @entity5750 + monocytes which were sorted from @entity1 peripheral blood mononuclear cells. Cell viability was assessed by @entity3460 exclusion test. Cells were stained with Liu's dye for observation of morphology. Expression of surface antigens was examined by flow cytometric analysis. Phagocytosis and generation of reactive @entity26 species (ROS), as functional assays, were evaluated by counting engulfed @entity375 and DCFH-DA reaction. The viability of macrophages was not significantly reduced by AM. AM at nontoxic concentrations markedly increased cytoplasmic vacuoles. The expression of surface @entity5750 , @entity4071 , @entity4210 , and HLA-DR was suppressed. The phagocytosis function, but not ROS production, of macrophages was inhibited by AM. @entity71623 could inhibit the differentiation and activation of @entity1 macrophages. It may have potential to be developed as a biological response modifier for inflammatory diseases.

title: XXXX , a Honey Medicinal Mushroom, Armillaria mellea (Higher Basidiomycetes) Component, Inhibits Differentiation and Activation of @entity1 Macrophages.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3460 :: ('MESH:D014343', 'Chemical') :: ['trypan blue']

entities_list: @entity71623 :: ('MESH:C043543', 'Chemical') :: ['Armillaridin']

entities_list: @entity71624 :: ('CHEBI:62732', 'Chemical') :: ['aromatic ester']

answer: @entity71623 :: (MESH:C043543,Chemical) :: ['Armillaridin']


abstract: @entity71623 (AM) is an @entity71624 compound isolated from honey medicinal mushroom, Armillaria mellea, which has anti- @entity5 potential. This study was designed to examine the effects of AM on differentiation and activation macrophages, the major ontogeny of innate immunity. Macrophages were derived from @entity5750 + monocytes which were sorted from @entity1 peripheral blood mononuclear cells. Cell viability was assessed by @entity3460 exclusion test. Cells were stained with Liu's dye for observation of morphology. Expression of surface antigens was examined by flow cytometric analysis. Phagocytosis and generation of reactive @entity26 species (ROS), as functional assays, were evaluated by counting engulfed @entity375 and DCFH-DA reaction. The viability of macrophages was not significantly reduced by AM. AM at nontoxic concentrations markedly increased cytoplasmic vacuoles. The expression of surface @entity5750 , @entity4071 , @entity4210 , and HLA-DR was suppressed. The phagocytosis function, but not ROS production, of macrophages was inhibited by AM. @entity71623 could inhibit the differentiation and activation of @entity1 macrophages. It may have potential to be developed as a biological response modifier for inflammatory diseases.

title: @entity71623 , a Honey Medicinal Mushroom, Armillaria mellea (Higher Basidiomycetes) Component, Inhibits Differentiation and Activation of XXXX Macrophages.

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: Five adjuvants were tested for their effect on the immune response in @entity840 to the hemagglutinin antigen of influenza virus strain B/Panama. Vaccines containing 924 micrograms of hemagglutinin antigen/ml were prepared at high and low doses of Freund's complete and incomplete adjuvants, Syntex adjuvant, RIBI's adjuvant, TiterMax adjuvant, and @entity11873 adjuvant. Responses to these vaccines were compared with those to a control vaccine containing influenza virus B/Panama hemagglutinin antigen and saline. On day 28, vaccines containing the following adjuvant doses had significantly higher titers than the titer for the control: Freund adjuvants at high and low doses, RIBI at high dose, TiterMax at high and low doses, and @entity11873 at high dose. On day 42, vaccines containing the following adjuvant doses had significantly higher titers than that for the control: Freund adjuvants at high and low doses, RIBI at high dose, TiterMax at high dose, and @entity11873 at high dose. Freund adjuvants at high and low doses, RIBI adjuvant at high dose, and @entity11873 at high dose caused significantly greater swelling at the inoculation site than did the control vaccine. TiterMax adjuvant at high and low doses, and @entity11873 at low dose caused minor swelling at the inoculation site, but it was not significantly different from the swelling caused by the control vaccine. Syntex adjuvant at high and low doses, RIBI at low dose, and control (saline/antigen) at high and low doses caused no swelling after inoculation. Overall, the high dose of adjuvants caused greater tissue swelling than did the low dose of adjuvants.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Comparison of the effects of five adjuvants on the antibody response to influenza virus antigen in XXXX .

entities_list: @entity11873 :: ('MESH:C012714', 'Chemical') :: ['aluminum phosphate']

answer: @entity840 :: (10141,Species) :: ['guinea pigs']


abstract: BACKGROUND: @entity2175 ( @entity2175 ) is projected to affect 439 million @entity1 by 2030. Medical management focuses on controlling blood @entity413 levels pharmacologically in a disease that is closely related to lifestyle factors such as diet and inactivity. Physical activity guidelines include aerobic exercise at intensities or volumes potentially unreachable for older adults limited by many co-morbidities. We aim to show for the first time the efficacy of a novel exercise modality, power training (high-velocity, high-intensity progressive resistance training or PRT), in older adults with @entity2175 as a means for improving glycemic control and targeting many associated metabolic and physiological outcomes. Eligibility criteria included community-dwelling @entity1 and @entity1 previously diagnosed with @entity2175 who met the current @entity209 according to the International @entity6 Federation. @entity1 were randomized to a fully supervised power training intervention or sham exercise control group for 12  months. Intervention group @entity1 performed whole body machine-based power training at 80%1RM, 3  days per week. The control group undertook the same volume of non-progressive, low-intensity training. @entity1 were assessed at baseline, 6  months and 12  months and followed for a further 5  years, during which time @entity1 were advised to exercise at moderate-high intensity. Glycemic control (HbA1c) and insulin resistance as measured by the homeostatic model assessment 2 (HOMA2-IR) were the primary outcomes of the trial. Outcome assessors were blinded to group assignment and @entity1 were blinded to the investigators' hypothesis regarding the most effective intervention. RESULTS: We recruited 103 @entity1 (48.5  % @entity1 , 71.6        5.6  years). @entity1 had 5.1        1.8 chronic diseases, had been diagnosed with @entity2175 for 8        6  years and had a body mass index (BMI) of 31.6        4.0  kg/m(2). Fasting @entity413 and insulin were 7.3        2.4  mmol/L and 10.6        6.3  mU/L, respectively. HbA1c was 54        12  mmol/mol. Eighty-six @entity1 completed the 12-month assessment and follow-up is ongoing. This cohort had a lower-than-expected dropout (n   =   14, 14  %) over the 12-month intervention period. CONCLUSIONS: Power training may be a feasible adjunctive therapy for improving glycemic control for the growing epidemic of @entity2175 in older adults. TRIAL REGISTRATION: Australian and New Zealand Clinical Trials Registry ACTRN12606000436572 (24 September 2006).

title: Graded Resistance Exercise And Type 2 XXXX in Older adults (The GREAT2DO study): methods and baseline cohort characteristics of a randomized controlled trial.

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['T2D', 'Type 2 diabetes']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Participants', 'people', 'men']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['definition of metabolic syndrome']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: UNASSIGNED: @entity72 ( @entity72 ) are a group of conditions that @entity854 in the neuroanatomy of multiple brain regions. The variability in the development of intelligence and language among individuals on the @entity2438 spectrum has long been acknowledged, but it remains unknown whether these differences impact on the neuropathology of @entity72 . In this study, we aimed to compare associations between surface-based regional brain measures and general intelligence (IQ) scores in @entity72 individuals with and without a history of @entity10791 . We included 64 @entity72 adults of normal intelligence (37 without a history of @entity10791 and 27 with a history of @entity10791 ). Regions with a significant association between verbal and nonverbal IQ and measures of cortical thickness (CT), surface area, and cortical volume were first identified in the combined sample of individuals with @entity72 and controls. Thicker dorsal frontal and temporal cortices, and thinner lateral orbital frontal and parieto-occipital cortices were associated with greater and lower verbal IQ scores, respectively. Correlations between cortical volume and verbal IQ were observed in similar regions as revealed by the CT analysis. A significant difference between @entity72 individuals with and without a history of @entity10791 in the association between CT and verbal IQ was evident in the parieto-occipital region. These results indicate that @entity72 subgroups defined on the basis of differential language trajectories in childhood can have different associations between verbal IQ and brain measures in adulthood despite achieving similar levels of cognitive performance. @entity2438 Res 2015, 8: 556-566.    2015 International Society for @entity2438 Research, Wiley Periodicals, Inc.

title: Relationship Between Surface-Based Brain Morphometric Measures and Intelligence in XXXX Spectrum Disorders: Influence of History of Language Delay.

entities_list: @entity10791 :: ('MESH:D007805', 'Disease') :: ['language delay and 80 neurotypicals', 'language delay']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['show abnormalities']

entities_list: @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'Autism spectrum disorders']

entities_list: @entity2438 :: ('MESH:D001321', 'Disease') :: ['autism', 'Autism']

answer: @entity2438 :: (MESH:D001321,Disease) :: ['Autism']


abstract: In a regional mental health activity for residents who have been evacuated for over three years on account of the @entity203 of Mt. Unzen-Fugen, a crisis intervention of the author took place in 76 @entity1 (21 males and 55 females) between June 1992 and November 1994. Most of them were over 41 in both sexes and half of female subjects was over 61. Using ICD-10, 57.9% of total were tentatively diagnosed as having @entity308 (F32, F34.1, F41.2 and F43.2). Of the 76 cases, 49 @entity1 improved with counseling, 22 @entity1 received a prescription of psychotropics from general practitioners and 5 @entity1 required outpatient care or hospitalization at @entity146 or geriatric institutions. The outcome as of November 1994 was 60 remitted cases including 6 relapse cases, 6 worsened cases and 10 unchanged cases. The case history and the reality of crisis intervention was introduced on some cases and the evacuated @entity1 's peculiar psychology, that mental scars and grief after experiencing the disaster are unspoken and kept locked in their hearts, was discussed. On the basis of the above results and discussion, I considered the meaning of visiting the evacuees' shelters and emphasized the importance of the following basic strategies of crisis intervention to evacuated @entity1 : 1. to give them counseling so that they can accept their devastating experiences as part of their life, 2. to give support to the whole family, 3. to work in close cooperation with general doctors in cases requiring drug therapy. Furthermore, it was insisted that it is necessary to establish a disaster mental health system to give support to evacuees who need @entity146 help on a long time scale not just immediately after the disaster. Finally, I pointed out the undeveloped level of disaster mental health activities in Japan and referred to future problems.

title: [Mental health activities for evacuees of the XXXX of Mt. Unzen-Fugen--crisis intervention of a psychiatrist].

entities_list: @entity203 :: ('MESH:D003875', 'Disease') :: ['volcanic eruption']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity203 :: (MESH:D003875,Disease) :: ['volcanic eruption']


abstract: BACKGROUND: Mutations affecting RAS genes are now established predictive markers of nonresponse to anti- @entity470 antibodies in advanced @entity14 . This analysis assessed the prognostic and predictive impact of extended RAS and @entity10160 gene mutation status in @entity1 receiving @entity416 plus or minus bevacizumab (  @entity1138 ) in the randomised phase III MAX study. METHODS: DNA was extracted from archival macrodissected @entity406 -fixed paraffin-embedded @entity5 tissue. Mutation status was determined using pyrosequencing, confirmed with Sanger sequencing (for equivocal RAS) and correlated with efficacy outcomes. Predictive analyses were undertaken using a test for interaction involving both C vs CB+CBM. RESULTS: Of the available 280 of the 471 (59.4%) @entity1 , mutations in @entity984 exons 2, 3 and 4 and NRAS 2, 3 and 4 were as follows: 32%, 2.9%, 2.2%, 1.4%, 0.7% and 0% (total RAS MT 39%). The @entity10160 MT rate was 7.5% exon 9 and 3.6% exon 20. Extended RAS gene mutation status ( @entity7097 vs MT) had no prognostic impact for PFS (HR 0.91 (0.71-1.17)) or @entity3012 (HR 0.95 (0.71-1.25)). The RAS gene mutation status was not predictive of the effectiveness of bevacizumab for PFS (HR 0.56 (0.37-0.85) for RAS MT and HR 0.69 (0.5-0.97) for RAS @entity7097 ; P for interaction 0.50). The @entity10160 mutation was neither predictive for bevacizumab effect nor prognostic. CONCLUSION: Of @entity984 exon 2 @entity7097 @entity1 , 10% had additional RAS mutations. Neither all RAS gene mutation status nor @entity10160 mutation status was prognostic for PFS or @entity3012 , or predictive of bevacizumab outcome in @entity1 with advanced @entity14 .

title: Correlation of extended RAS and @entity10160 gene mutation status with outcomes from the phase III AGITG MAX STUDY involving @entity416 alone or in combination with bevacizumab plus or minus XXXX in advanced @entity14 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity416 :: ('MESH:C110904', 'Chemical') :: ['capecitabine']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

answer: @entity1138 :: (MESH:D016685,Chemical) :: ['mitomycin C']


abstract: BACKGROUND: Mutations affecting RAS genes are now established predictive markers of nonresponse to anti- @entity470 antibodies in advanced @entity14 . This analysis assessed the prognostic and predictive impact of extended RAS and @entity10160 gene mutation status in @entity1 receiving @entity416 plus or minus bevacizumab (  @entity1138 ) in the randomised phase III MAX study. METHODS: DNA was extracted from archival macrodissected @entity406 -fixed paraffin-embedded @entity5 tissue. Mutation status was determined using pyrosequencing, confirmed with Sanger sequencing (for equivocal RAS) and correlated with efficacy outcomes. Predictive analyses were undertaken using a test for interaction involving both C vs CB+CBM. RESULTS: Of the available 280 of the 471 (59.4%) @entity1 , mutations in @entity984 exons 2, 3 and 4 and NRAS 2, 3 and 4 were as follows: 32%, 2.9%, 2.2%, 1.4%, 0.7% and 0% (total RAS MT 39%). The @entity10160 MT rate was 7.5% exon 9 and 3.6% exon 20. Extended RAS gene mutation status ( @entity7097 vs MT) had no prognostic impact for PFS (HR 0.91 (0.71-1.17)) or @entity3012 (HR 0.95 (0.71-1.25)). The RAS gene mutation status was not predictive of the effectiveness of bevacizumab for PFS (HR 0.56 (0.37-0.85) for RAS MT and HR 0.69 (0.5-0.97) for RAS @entity7097 ; P for interaction 0.50). The @entity10160 mutation was neither predictive for bevacizumab effect nor prognostic. CONCLUSION: Of @entity984 exon 2 @entity7097 @entity1 , 10% had additional RAS mutations. Neither all RAS gene mutation status nor @entity10160 mutation status was prognostic for PFS or @entity3012 , or predictive of bevacizumab outcome in @entity1 with advanced @entity14 .

title: Correlation of extended RAS and @entity10160 gene mutation status with outcomes from the phase III AGITG MAX STUDY involving @entity416 alone or in combination with bevacizumab plus or minus @entity1138 in advanced XXXX .

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: BACKGROUND: Mutations affecting RAS genes are now established predictive markers of nonresponse to anti- @entity470 antibodies in advanced @entity14 . This analysis assessed the prognostic and predictive impact of extended RAS and @entity10160 gene mutation status in @entity1 receiving @entity416 plus or minus bevacizumab (  @entity1138 ) in the randomised phase III MAX study. METHODS: DNA was extracted from archival macrodissected @entity406 -fixed paraffin-embedded @entity5 tissue. Mutation status was determined using pyrosequencing, confirmed with Sanger sequencing (for equivocal RAS) and correlated with efficacy outcomes. Predictive analyses were undertaken using a test for interaction involving both C vs CB+CBM. RESULTS: Of the available 280 of the 471 (59.4%) @entity1 , mutations in @entity984 exons 2, 3 and 4 and NRAS 2, 3 and 4 were as follows: 32%, 2.9%, 2.2%, 1.4%, 0.7% and 0% (total RAS MT 39%). The @entity10160 MT rate was 7.5% exon 9 and 3.6% exon 20. Extended RAS gene mutation status ( @entity7097 vs MT) had no prognostic impact for PFS (HR 0.91 (0.71-1.17)) or @entity3012 (HR 0.95 (0.71-1.25)). The RAS gene mutation status was not predictive of the effectiveness of bevacizumab for PFS (HR 0.56 (0.37-0.85) for RAS MT and HR 0.69 (0.5-0.97) for RAS @entity7097 ; P for interaction 0.50). The @entity10160 mutation was neither predictive for bevacizumab effect nor prognostic. CONCLUSION: Of @entity984 exon 2 @entity7097 @entity1 , 10% had additional RAS mutations. Neither all RAS gene mutation status nor @entity10160 mutation status was prognostic for PFS or @entity3012 , or predictive of bevacizumab outcome in @entity1 with advanced @entity14 .

title: Correlation of extended RAS and XXXX gene mutation status with outcomes from the phase III AGITG MAX STUDY involving @entity416 alone or in combination with bevacizumab plus or minus @entity1138 in advanced @entity14 .

answer: @entity10160 :: (5290,Gene) :: ['PIK3CA']


abstract: BACKGROUND: Mutations affecting RAS genes are now established predictive markers of nonresponse to anti- @entity470 antibodies in advanced @entity14 . This analysis assessed the prognostic and predictive impact of extended RAS and @entity10160 gene mutation status in @entity1 receiving @entity416 plus or minus bevacizumab (  @entity1138 ) in the randomised phase III MAX study. METHODS: DNA was extracted from archival macrodissected @entity406 -fixed paraffin-embedded @entity5 tissue. Mutation status was determined using pyrosequencing, confirmed with Sanger sequencing (for equivocal RAS) and correlated with efficacy outcomes. Predictive analyses were undertaken using a test for interaction involving both C vs CB+CBM. RESULTS: Of the available 280 of the 471 (59.4%) @entity1 , mutations in @entity984 exons 2, 3 and 4 and NRAS 2, 3 and 4 were as follows: 32%, 2.9%, 2.2%, 1.4%, 0.7% and 0% (total RAS MT 39%). The @entity10160 MT rate was 7.5% exon 9 and 3.6% exon 20. Extended RAS gene mutation status ( @entity7097 vs MT) had no prognostic impact for PFS (HR 0.91 (0.71-1.17)) or @entity3012 (HR 0.95 (0.71-1.25)). The RAS gene mutation status was not predictive of the effectiveness of bevacizumab for PFS (HR 0.56 (0.37-0.85) for RAS MT and HR 0.69 (0.5-0.97) for RAS @entity7097 ; P for interaction 0.50). The @entity10160 mutation was neither predictive for bevacizumab effect nor prognostic. CONCLUSION: Of @entity984 exon 2 @entity7097 @entity1 , 10% had additional RAS mutations. Neither all RAS gene mutation status nor @entity10160 mutation status was prognostic for PFS or @entity3012 , or predictive of bevacizumab outcome in @entity1 with advanced @entity14 .

title: Correlation of extended RAS and @entity10160 gene mutation status with outcomes from the phase III AGITG MAX STUDY involving XXXX alone or in combination with bevacizumab plus or minus @entity1138 in advanced @entity14 .

answer: @entity416 :: (MESH:C110904,Chemical) :: ['capecitabine']


abstract: BACKGROUND: Activation of the Notch pathway has been reported in various types of @entity5 . However, the role of the hairy/enhancer-of-split related with YRPW motif protein 1 ( @entity21507 ) in @entity421 is unknown. We examined the function of @entity21507 in @entity421 . METHODS: Expression of @entity21507 was studied in @entity1 @entity421 . The effects of @entity21507 in @entity421 were evaluated in vitro and in a xenograft model. Moreover, we examined the function of @entity1495 ( @entity1495 ) as a downstream effector of @entity21507 . RESULTS: @entity21507 was upregulated in @entity1 @entity421 . Knockdown of @entity21507 inhibited the invasion of @entity421 cell lines. In contrast, the forced expression of @entity21507 increased the invasion of mesenchymal stem cell. In addition, lung metastases were significantly inhibited by the knockdown of @entity21507 . We found that @entity1495 was a downstream effector of @entity21507 that promotes the invasion of @entity421 cells. Knockdown of @entity21507 decreased the expression of @entity1495 . Addition of @entity1495 rescued the invasion of @entity421 cells that had been rendered less invasive by knockdown of @entity21507 expression. CONCLUSIONS: Our findings suggested that @entity21507 augmented the @entity3 of @entity421 via upregulation of @entity1495 expression. Therefore, inhibition of @entity21507 may be a novel therapeutic strategy for preventing @entity3 .

title: Hairy/enhancer-of-split related with YRPW motif protein 1 promotes @entity3 via XXXX expression.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']

entities_list: @entity1495 :: ('4318', 'Gene') :: ['matrix metallopeptidase 9', 'MMP9']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'osteosarcoma metastasis']

answer: @entity1495 :: (4318,Gene) :: ['matrix metallopeptidase 9']


abstract: BACKGROUND: Activation of the Notch pathway has been reported in various types of @entity5 . However, the role of the hairy/enhancer-of-split related with YRPW motif protein 1 ( @entity21507 ) in @entity421 is unknown. We examined the function of @entity21507 in @entity421 . METHODS: Expression of @entity21507 was studied in @entity1 @entity421 . The effects of @entity21507 in @entity421 were evaluated in vitro and in a xenograft model. Moreover, we examined the function of @entity1495 ( @entity1495 ) as a downstream effector of @entity21507 . RESULTS: @entity21507 was upregulated in @entity1 @entity421 . Knockdown of @entity21507 inhibited the invasion of @entity421 cell lines. In contrast, the forced expression of @entity21507 increased the invasion of mesenchymal stem cell. In addition, lung metastases were significantly inhibited by the knockdown of @entity21507 . We found that @entity1495 was a downstream effector of @entity21507 that promotes the invasion of @entity421 cells. Knockdown of @entity21507 decreased the expression of @entity1495 . Addition of @entity1495 rescued the invasion of @entity421 cells that had been rendered less invasive by knockdown of @entity21507 expression. CONCLUSIONS: Our findings suggested that @entity21507 augmented the @entity3 of @entity421 via upregulation of @entity1495 expression. Therefore, inhibition of @entity21507 may be a novel therapeutic strategy for preventing @entity3 .

title: Hairy/enhancer-of-split related with YRPW motif protein 1 promotes XXXX via @entity1495 expression.

answer: @entity3 :: (MESH:D009362,Disease) :: ['osteosarcoma metastasis']


abstract: A salient feature of the failing heart is metabolic remodeling towards predominant @entity413 metabolism and activation of the fetal gene program. @entity2240 is a multitargeted receptor @entity4149 kinase inhibitor used for the treatment of highly vascularized @entity5 . In @entity6 @entity1 , @entity2240 significantly decreases blood @entity413 . However, a considerable proportion of @entity2240 -treated @entity1 develop @entity299 or failure. We asked whether @entity2240 treatment results in shift towards glycolysis in the heart. @entity413 uptake by the heart was increased fivefold in @entity19 treated with @entity2240 . Transcript analysis by qPCR revealed an induction of genes associated with glycolysis and reactivation of the fetal gene program. Additionally, we observed a shift in the enzyme @entity2388 kinase from the adult M1 (PKM1) isoform to the fetal M2 ( @entity17341 ) isoform, a hallmark of the Warburg Effect. This novel observation led us to examine whether a similar shift occurs in @entity1 @entity712 . Examination of tissue from @entity1 with @entity712 similarly displayed an induction of @entity17341 . Moreover, this phenomenon was partially reversed following mechanical unloading. We propose that @entity2388 kinase isoform switching represents a novel feature of the fetal gene program in the failing heart.

title: A XXXX signature in the failing heart.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity2240 :: ('MESH:C473478', 'Chemical') :: ['Sunitinib', 'sunitinib']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']

entities_list: @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']

answer: @entity17341 :: (5315,Gene) :: ['PKM2']


abstract: BACKGROUND: Fractures of the proximal ulna are rare and usually managed surgically. Strong fixation of the harware is essential to obtain good outcomes. We report our experience with pre-contoured locking plate fixation of complex olecranon @entity174 and present a critical appraisal of the outcomes. HYPOTHESIS: Pre-contoured locking plates provide good outcomes, but their clinical tolerance may be limited in some instances. MATERIALS AND METHODS: From September 2009 to December 2011, 28 @entity1 were managed using a pre-contoured locking compression plate ( @entity2444 (  )). Among them, 6 were excluded because of missing data, which left 22 @entity1 (11 males and 11 females) with a mean age of 55.7 years, including 12 who were employed. The @entity174 was on the dominant side in 11 @entity1 . According to the Mayo Clinic classification, 15 @entity174 were @entity196 . In addition to the ulnar @entity174 , a @entity174 was present in 9 @entity1 and a @entity174 in 5 @entity1 . Functional recovery was assessed using the Broberg-Morrey score and Mayo Elbow Performance Score (MEPS). Radiographs were obtained to evaluate the quality of @entity174 reduction and @entity174 healing, as well as to look for ossifications and @entity571 . RESULTS: Mean follow-up was 20 months. Flexion was 131  , extension loss was 9.5  , pronation was 79  , and supination was 80.5  . The mean Broberg-Morrey score was 96.7 and the mean MEPS score 96.6. @entity174 healing occurred in all @entity1 , within a mean of 10.6 weeks. Evidence of early @entity571 was found in 6 @entity1 , ossifications in 3 @entity1 , and @entity8213 in 1 @entity1 . An @entity281 was successfully treated with lavage and antibiotic therapy in 1 @entity1 . The fixation hardware was removed in 6 @entity1 . No prognostic factors were identified. DISCUSSION-CONCLUSION: Our hypothesis was confirmed. The outcomes are encouraging and comparable to those reported in the literature. The critical issue is the limited clinical tolerance of the plate with a high rate of posterior impingement requiring plate removal (27%). Rigorous technique is essential during plate implantation. LEVEL OF EVIDENCE: Level IV, retrospective study.

title: Critical analysis of XXXX management by pre-contoured locking plates.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'coronoid process fracture', 'radial head fracture', 'Fracture', 'fracture']

entities_list: @entity8213 :: ('MESH:D013580', 'Disease') :: ['synostosis']

entities_list: @entity196 :: ('MESH:D020754', 'Disease') :: ['type II and 7 type III']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity174 :: (MESH:D050723,Disease) :: ['olecranon fracture']


abstract: UNASSIGNED: @entity463 ( @entity463 ) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of @entity11 stem cells (GSCs) has been shown to contribute to tumorigenesis, recurrence and treatment resistance. Particularly, @entity5439 -positive @entity11 cells have been shown to represent the subpopulation that confers @entity11 radioresistance and suggested to be the source of @entity5 recurrence after radiation. Thus, a better understanding and the development of agents which target GSCs could potentially lead to a significant improvement in treating @entity463 @entity1 . Here, we demonstrated that @entity1477 (an antistress protein) was highly expressed in @entity463 cells along with @entity3546 and Notch and correlated to the development of GSCs. @entity5439 + GSCs exhibited enhanced migration/invasion and self-renewal abilities. When @entity1477 was silenced, GSC properties were suppressed and the sensitivity towards irradiation increased. In addition, the level of microRNA 205 appeared to be negatively associated with @entity1477 expression. Our previous study indicated that @entity20667 (PT) possessed anticancer stem cell properties in @entity157 . Thus, we examined whether PT is also effective against GSCs. We found that PT-treated GSCs exhibited suppressed self-renewal and irradiation-resistant abilities. PT-mediated effects were associated with an increase of @entity16106 . Finally, we showed that PT treatment suppressed tumorigenesis in GSC xenograft @entity19 . In conclusion, we provided evidence that @entity1477 / @entity16106 @entity2270 played an important role in GSC maintenance and irradiation resistance. PT treatment suppressed GSC development via negatively modulating @entity1477 signaling. PT may be considered for combined therapeutic agent to enhance irradiation efficacy in @entity463 @entity1 .

title: XXXX suppressed irradiation-resistant @entity11 stem cells by modulating @entity1477 / @entity16106 @entity2270 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity20667 :: ('MESH:C107773', 'Chemical') :: ['pterostilbene']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'Glioblastoma multiforme']

answer: @entity20667 :: (MESH:C107773,Chemical) :: ['Pterostilbene']


abstract: UNASSIGNED: @entity463 ( @entity463 ) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of @entity11 stem cells (GSCs) has been shown to contribute to tumorigenesis, recurrence and treatment resistance. Particularly, @entity5439 -positive @entity11 cells have been shown to represent the subpopulation that confers @entity11 radioresistance and suggested to be the source of @entity5 recurrence after radiation. Thus, a better understanding and the development of agents which target GSCs could potentially lead to a significant improvement in treating @entity463 @entity1 . Here, we demonstrated that @entity1477 (an antistress protein) was highly expressed in @entity463 cells along with @entity3546 and Notch and correlated to the development of GSCs. @entity5439 + GSCs exhibited enhanced migration/invasion and self-renewal abilities. When @entity1477 was silenced, GSC properties were suppressed and the sensitivity towards irradiation increased. In addition, the level of microRNA 205 appeared to be negatively associated with @entity1477 expression. Our previous study indicated that @entity20667 (PT) possessed anticancer stem cell properties in @entity157 . Thus, we examined whether PT is also effective against GSCs. We found that PT-treated GSCs exhibited suppressed self-renewal and irradiation-resistant abilities. PT-mediated effects were associated with an increase of @entity16106 . Finally, we showed that PT treatment suppressed tumorigenesis in GSC xenograft @entity19 . In conclusion, we provided evidence that @entity1477 / @entity16106 @entity2270 played an important role in GSC maintenance and irradiation resistance. PT treatment suppressed GSC development via negatively modulating @entity1477 signaling. PT may be considered for combined therapeutic agent to enhance irradiation efficacy in @entity463 @entity1 .

title: @entity20667 suppressed irradiation-resistant @entity11 stem cells by modulating @entity1477 / @entity16106 XXXX .

answer: @entity2270 :: (MESH:C566610,Disease) :: ['axis']


abstract: UNASSIGNED: @entity463 ( @entity463 ) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of @entity11 stem cells (GSCs) has been shown to contribute to tumorigenesis, recurrence and treatment resistance. Particularly, @entity5439 -positive @entity11 cells have been shown to represent the subpopulation that confers @entity11 radioresistance and suggested to be the source of @entity5 recurrence after radiation. Thus, a better understanding and the development of agents which target GSCs could potentially lead to a significant improvement in treating @entity463 @entity1 . Here, we demonstrated that @entity1477 (an antistress protein) was highly expressed in @entity463 cells along with @entity3546 and Notch and correlated to the development of GSCs. @entity5439 + GSCs exhibited enhanced migration/invasion and self-renewal abilities. When @entity1477 was silenced, GSC properties were suppressed and the sensitivity towards irradiation increased. In addition, the level of microRNA 205 appeared to be negatively associated with @entity1477 expression. Our previous study indicated that @entity20667 (PT) possessed anticancer stem cell properties in @entity157 . Thus, we examined whether PT is also effective against GSCs. We found that PT-treated GSCs exhibited suppressed self-renewal and irradiation-resistant abilities. PT-mediated effects were associated with an increase of @entity16106 . Finally, we showed that PT treatment suppressed tumorigenesis in GSC xenograft @entity19 . In conclusion, we provided evidence that @entity1477 / @entity16106 @entity2270 played an important role in GSC maintenance and irradiation resistance. PT treatment suppressed GSC development via negatively modulating @entity1477 signaling. PT may be considered for combined therapeutic agent to enhance irradiation efficacy in @entity463 @entity1 .

title: @entity20667 suppressed irradiation-resistant @entity11 stem cells by modulating @entity1477 / XXXX @entity2270 .

answer: @entity16106 :: (406988,Gene) :: ['miR-205']


abstract: UNASSIGNED: @entity463 ( @entity463 ) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of @entity11 stem cells (GSCs) has been shown to contribute to tumorigenesis, recurrence and treatment resistance. Particularly, @entity5439 -positive @entity11 cells have been shown to represent the subpopulation that confers @entity11 radioresistance and suggested to be the source of @entity5 recurrence after radiation. Thus, a better understanding and the development of agents which target GSCs could potentially lead to a significant improvement in treating @entity463 @entity1 . Here, we demonstrated that @entity1477 (an antistress protein) was highly expressed in @entity463 cells along with @entity3546 and Notch and correlated to the development of GSCs. @entity5439 + GSCs exhibited enhanced migration/invasion and self-renewal abilities. When @entity1477 was silenced, GSC properties were suppressed and the sensitivity towards irradiation increased. In addition, the level of microRNA 205 appeared to be negatively associated with @entity1477 expression. Our previous study indicated that @entity20667 (PT) possessed anticancer stem cell properties in @entity157 . Thus, we examined whether PT is also effective against GSCs. We found that PT-treated GSCs exhibited suppressed self-renewal and irradiation-resistant abilities. PT-mediated effects were associated with an increase of @entity16106 . Finally, we showed that PT treatment suppressed tumorigenesis in GSC xenograft @entity19 . In conclusion, we provided evidence that @entity1477 / @entity16106 @entity2270 played an important role in GSC maintenance and irradiation resistance. PT treatment suppressed GSC development via negatively modulating @entity1477 signaling. PT may be considered for combined therapeutic agent to enhance irradiation efficacy in @entity463 @entity1 .

title: @entity20667 suppressed irradiation-resistant XXXX stem cells by modulating @entity1477 / @entity16106 @entity2270 .

answer: @entity11 :: (MESH:D005910,Disease) :: ['glioma']


abstract: UNASSIGNED: @entity463 ( @entity463 ) is the most aggressive type characterized by relapse and resistance even with the combination of radio- and chemotherapy. The presence of @entity11 stem cells (GSCs) has been shown to contribute to tumorigenesis, recurrence and treatment resistance. Particularly, @entity5439 -positive @entity11 cells have been shown to represent the subpopulation that confers @entity11 radioresistance and suggested to be the source of @entity5 recurrence after radiation. Thus, a better understanding and the development of agents which target GSCs could potentially lead to a significant improvement in treating @entity463 @entity1 . Here, we demonstrated that @entity1477 (an antistress protein) was highly expressed in @entity463 cells along with @entity3546 and Notch and correlated to the development of GSCs. @entity5439 + GSCs exhibited enhanced migration/invasion and self-renewal abilities. When @entity1477 was silenced, GSC properties were suppressed and the sensitivity towards irradiation increased. In addition, the level of microRNA 205 appeared to be negatively associated with @entity1477 expression. Our previous study indicated that @entity20667 (PT) possessed anticancer stem cell properties in @entity157 . Thus, we examined whether PT is also effective against GSCs. We found that PT-treated GSCs exhibited suppressed self-renewal and irradiation-resistant abilities. PT-mediated effects were associated with an increase of @entity16106 . Finally, we showed that PT treatment suppressed tumorigenesis in GSC xenograft @entity19 . In conclusion, we provided evidence that @entity1477 / @entity16106 @entity2270 played an important role in GSC maintenance and irradiation resistance. PT treatment suppressed GSC development via negatively modulating @entity1477 signaling. PT may be considered for combined therapeutic agent to enhance irradiation efficacy in @entity463 @entity1 .

title: @entity20667 suppressed irradiation-resistant @entity11 stem cells by modulating XXXX / @entity16106 @entity2270 .

answer: @entity1477 :: (3309,Gene) :: ['GRP78']


abstract: The cellular mechanisms involved in activation of mechanosensitive visceral sensory nerves are poorly understood. The major goal of this study was to determine the effect of mechanical stimulation on intracellular @entity460 concentration ([ @entity141 ]i) using nodose sensory neurons grown in culture. Primary cultures of nodose sensory neurons were prepared by enzymatic dispersion from nodose ganglia of 4-8 week old @entity35 . Whole cell [ @entity141 ]i was measured by a microscopic digital image analysis system in @entity593 loaded single neurons. Brief mechanical stimulation of individual nodose sensory neurons was achieved by deformation of the cell surface with a glass micropipette. In 31 of 50 neurons (62%), mechanical stimulation increased [ @entity141 ]i from 125 +/- 8 to 763 +/- 89 nM measured approximately 10 s after stimulation. [ @entity141 ]i then declined gradually, returning to near basal levels over a period of minutes. [ @entity141 ]i failed to increase after mechanical stimulation in the remaining 19 neurons. The mechanically-induced rise in [ @entity141 ]i was essentially abolished after the neurons were incubated for 5-10 min in zero @entity141 buffer (n = 7) or after addition of @entity2287 (10 microM), a blocker of stretch-activated ion channels (n = 5). The effect of @entity2287 was reversed after removal of @entity2287 . The results indicate that: (1) mechanical stretch increases [ @entity141 ]i in a subpopulation of nodose sensory neurons in culture, and (2) the stretch-induced increase in [ @entity141 ]i is dependent on influx of @entity141 from extracellular fluid and is reversibly blocked by @entity2287 . The findings suggest that opening of stretch-activated ion channels in response to mechanical deformation leads to an increase in @entity141 concentration in visceral sensory neurons.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Mechanical stimulation increases intracellular XXXX concentration in nodose sensory neurons.

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: UNASSIGNED: The lack of signaling through MAPK pathways leads to a defective cellular response to the corresponding stimulus, but an improper hyperactivation of these routes results in deleterious effects as well. Protein phosphorylation is an activating modification for signal transmission through components of MAPK pathways and thus, protein phosphatases are key negative regulators of these cellular routes by limiting excessive signaling activity. However, in contrast to most of the protein kinases operating in MAPK pathways, protein phosphatases usually exhibit redundancy and promiscuity, which has limited the identification of their function. In order to identify new putative phosphatases operating in @entity375 MAPK signaling, we have taken advantage of growth inhibition promoted by overproduction of constitutively active components of the mating and cell wall integrity (CWI) pathways to perform a screen with a collection of 43 protein phosphatases or phosphatase-regulatory proteins. The phosphatases able to alleviate the induced growth inhibition when overproduced were further studied by testing their capacity to downregulate expression of mating and CWI responsive promoters and the consequences of their removal on MAPK signaling. Epistasis analysis placed the Ser/Thr protein phosphatase @entity71625 as a regulator of the mating MAPK module downstream the MAPKKK Ste11. The dual specificity phosphatase @entity9791 was found to be important for the maintenance of cell wall integrity and appropriate signaling through the CWI pathway. Moreover, we have found that @entity9794 and @entity65054 bind to the CWI MAPK @entity19624 . Together with known phosphatases of the mating and CWI pathway, as @entity9793 or @entity42731 , other putative negative regulators of both pathways that came up in the screening were @entity9794 , @entity71626 and @entity71627 . We show that @entity71627 physically interacts with @entity19624 and the mating MAPK Fus3. Elimination of @entity71627 results in increased signaling through these pathways, suggesting that this @entity4149 phosphatase, like @entity42731 and @entity42730 , plays a downregulatory role on both MAPKs.

title: Identification of putative negative regulators of XXXX signaling through a screening for protein phosphatases acting on cell wall integrity and mating MAPK pathways.

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']

answer: @entity375 :: (4932,Species) :: ['yeast']


abstract: INTRODUCTION: @entity1167 commonly results in varying degrees of @entity73 . Standard outcome measures used in the @entity1167 cohort do not rigorously evaluate for these injury patterns. We examined the utility of the Computerized Assessment for Mild @entity73 (CAMCI) in @entity1167 ( @entity1167 ) survivors. We hypothesized that @entity73 would be more severe in @entity1 who were @entity772 on hospital arrival. METHODS: Prospective cohort of @entity1167 survivors at a single tertiary care facility where @entity1 received neurocognitive testing using CAMCI. CAMCI results were subdivided into memory, attention, and executive functions. Scores between subjects who were @entity772 and were not @entity772 following resuscitation were compared using the Mann-Whitney test. RESULTS: Of 72 subjects included, the majority (N=44) were @entity772 following resuscitation with mean age of 54 (  14) years. The majority experienced a good neurologic outcome based on Cerebral Performance Category (N=47; 66%) and Modified Rankin Scale (N=38; 53%). Time from resuscitation to CAMCI testing was not associated with total CAMCI score in this cohort (Pearson's r(2) value -0.1941, p=0.20). @entity772 and not @entity772 subjects did not differ in their CAMCI overall scores (p=0.33), or in any subtest areas. The not @entity772 cohort had 1 subtest for which there was a Moderate Risk for mild @entity73 (Nonverbal Accuracy), and 2 for which there was a Moderately Low Risk (Verbal Accuracy and Executive Accuracy). The Comatose cohort had 4 subtests, which were deemed Moderately Low Risk for @entity73 (Verbal Accuracy, Attention Accuracy, Executive Accuracy and Nonverbal Accuracy). CONCLUSIONS: In-hospital CAMCI testing suggests memory, attention and executive impairment are commonly in @entity1 following resuscitation from @entity1167 . Outcome evaluations should test for deficits in memory, attention, and executive function.

title: Neurocognitive outcomes following successful resuscitation from XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive injury', 'cognitive deficits', 'Cognitive Injury']

entities_list: @entity772 :: ('MESH:D003128', 'Disease') :: ['comatose', 'Initially comatose', 'initially comatose']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest', 'Cardiac arrest', 'CA']

answer: @entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']


abstract: A lethal case of @entity3326 in a 42-year-old @entity1 with a history of @entity146 under treatment with @entity1767 is reported. The @entity1 , hospitalized many times in the past for @entity146 treatment, was then admitted for treatment of a relapse of the disease during a exceedingly hot period. The @entity1 complained of @entity1833 and stomach ache. It was necessary to increase the dose of @entity1767 to 2 mg, 3 times a day, and to give a single dose of @entity51470 100 mg. All tests proved normal except for @entity9153 274 U/l and @entity1133 14 mg/dl. On hospital day 2, went into @entity772 with high temperature, diaphoresis, @entity2011 , leucocytosis (WBC count 15,440 U/mm3), @entity1133 7 mg/dl, LDH 425 U/l, Na 114 mEq/l, K 2.5 mEq/l. The rapid improvement following hypertonic saline treatment encouraged a diagnosis of @entity11896 . On hospital day 7, continuing with the @entity1767 treatment, the @entity1 developed a high temperature and deterioration torpor. On hospital day 9, the @entity1 went back into @entity772 with temperature over 40 degrees C (104 degrees F), with fine myoclonia most visible on the face, and @entity2003 . The @entity9153 , rose from 5,169 to 28,060 U/l in less than 24 hours; the serum myoglobin rose to 41,000 ug/l. On day hospital 11 developed @entity177 . The picture deteriorated and @entity592 was no longer of use in controlling the fever. Then with a fever of over 42 degrees (108 degrees F) and the @entity9153 at 50,000 the @entity1 died. The autopsy demonstrated @entity5925 , a picture of widespread aspecific shock in all organs and picture of myoglobin-induced @entity5720 .

title: [ XXXX . A case report].

entities_list: @entity3326 :: ('MESH:D009459', 'Disease') :: ['neuroleptic malignant syndrome']

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['muscular rigidity']

entities_list: @entity11896 :: ('MESH:D014869', 'Disease') :: ['water intoxication']

entities_list: @entity51470 :: ('MESH:C028675', 'Chemical') :: ['perphenazine enanthate']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'bipolar psychiatric disorder']

entities_list: @entity5720 :: ('MESH:D007681', 'Disease') :: ['tabular necrosis of the kidney']

entities_list: @entity1833 :: ('MESH:D006212', 'Disease') :: ['hallucinations']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal, cardiac and respiratory insufficiency']

entities_list: @entity5925 :: ('MESH:D012206', 'Disease') :: ['widespread rhabdomyolysis']

entities_list: @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']

entities_list: @entity592 :: ('MESH:D003620', 'Chemical') :: ['dantrolene']

answer: @entity3326 :: (MESH:D009459,Disease) :: ['Neuroleptic malignant syndrome']


abstract: OBJECTIVES: @entity6 screening in England involves labour intensive manual grading of digital retinal images. We present the plan for an observational retrospective study of whether automated systems could replace one or more steps of @entity1 grading. METHODS: @entity1 aged 12 or older who attended the @entity6 Eye Screening programme, Homerton University Hospital (London) between 1 June 2012 and 4 November 2013 had macular and disc-centred retinal images taken. All screening episodes were manually graded and will additionally be graded by three automated systems. Each system will process all screening episodes, and screening performance (sensitivity, false positive rate, likelihood ratios) and diagnostic accuracy (95% confidence intervals of screening performance measures) will be quantified. A sub-set of gradings will be validated by an approved Reading Centre. Additional analyses will explore the effect of altering thresholds for disease detection within each automated system on screening performance. RESULTS: 2,782/20,258 @entity6 @entity1 were referred to ophthalmologists for further examination. Prevalence of @entity1020 (M1), @entity989 (R2), and @entity989 (R3) were 7.9%, 3.1% and 1.2%, respectively; 4749 (23%) @entity1 were diagnosed with background @entity989 (R1); 1.5% were considered ungradable by @entity1 graders. CONCLUSIONS: @entity989 prevalence was similar to other English diabetic screening programmes, so findings should be generalizable. The study population size will allow the detection of differences in screening performance between the @entity1 and automated grading systems as small as 2%. The project will compare performance and economic costs of manual versus automated systems.

title: A study of whether automated XXXX Image Assessment could replace manual grading steps in the English National Screening Programme.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['maculopathy']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes', 'Diabetic retinopathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['Retinopathy', 'retinopathy', 'proliferative retinopathy', 'pre-proliferative retinopathy']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetic Retinopathy']


abstract: The in vitro activity of ravuconazole (RVCZ) was compared with those of itraconazole (ITCZ) and terbinafine (TBF) against 73 dermatophyte isolates and 18 Candida spp. isolates recovered from @entity1 with @entity9202 at 4 dermatological clinics in Japan in 2011. The dermatophyte isolates consisted of @entity12734 (n=51), @entity12736 (n=20 : these strains were not identified by molecular phylogenetic analysis.), @entity12736 tonsurans (n=1), and @entity14476 (n=1). The Candida spp. isolates comprised @entity5132 (n=11), @entity7409 (n=5), @entity18203 (n=1), and C. pseudohaemulonii (n=1). RVCZ was highly active against all dermatophytes and all Candida spp. : the geometric mean (GM) MICs for @entity12734 and @entity12736 were 0.035  g/mL and MICs for T. tonsurans and @entity14476 were  <= 0.03 g/mL, and GM MICs for @entity5132 and @entity7409 were  <= 0.03 g/mL and MICs for @entity18203 and C. pseudohaemulonii were 0.25 and  <= 0.03 g/mL, respectively. Compared to RVCZ, ITCZ showed similar anti-dermatophytic and anti-Candida activities, while TBF had a slightly higher anti-dermatophytic but a markedly lower anti-Candida activity. These results suggest that RVCZ is a potential candidate systemic antifungal therapy against @entity6313 and other dermatomycoses that are refractory to topical antifungal therapy.

title: In vitro Antifungal Activity of Ravuconazole Against Isolates of Dermatophytes and Candida Species from @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity9202 :: ('MESH:D003881', 'Disease') :: ['dermatomycosis']

entities_list: @entity18203 :: ('4929', 'Species') :: ['C. guilliermondii']

entities_list: @entity6313 :: ('MESH:D014009', 'Disease') :: ['onychomycosis']

entities_list: @entity7409 :: ('5480', 'Species') :: ['C. parapsilosis']

entities_list: @entity12736 :: ('523103', 'Species') :: ['T. mentagrophytes', 'Trichophyton', 'Trichophyton mentagrophytes']

entities_list: @entity14476 :: ('63405', 'Species') :: ['M. canis', 'Microsporum canis']

entities_list: @entity12734 :: ('5551', 'Species') :: ['Trichophyton rubrum', 'T. rubrum']

answer: @entity9202 :: (MESH:D003881,Disease) :: ['Dermatomycoses']


abstract: The in vitro activity of ravuconazole (RVCZ) was compared with those of itraconazole (ITCZ) and terbinafine (TBF) against 73 dermatophyte isolates and 18 Candida spp. isolates recovered from @entity1 with @entity9202 at 4 dermatological clinics in Japan in 2011. The dermatophyte isolates consisted of @entity12734 (n=51), @entity12736 (n=20 : these strains were not identified by molecular phylogenetic analysis.), @entity12736 tonsurans (n=1), and @entity14476 (n=1). The Candida spp. isolates comprised @entity5132 (n=11), @entity7409 (n=5), @entity18203 (n=1), and C. pseudohaemulonii (n=1). RVCZ was highly active against all dermatophytes and all Candida spp. : the geometric mean (GM) MICs for @entity12734 and @entity12736 were 0.035  g/mL and MICs for T. tonsurans and @entity14476 were  <= 0.03 g/mL, and GM MICs for @entity5132 and @entity7409 were  <= 0.03 g/mL and MICs for @entity18203 and C. pseudohaemulonii were 0.25 and  <= 0.03 g/mL, respectively. Compared to RVCZ, ITCZ showed similar anti-dermatophytic and anti-Candida activities, while TBF had a slightly higher anti-dermatophytic but a markedly lower anti-Candida activity. These results suggest that RVCZ is a potential candidate systemic antifungal therapy against @entity6313 and other dermatomycoses that are refractory to topical antifungal therapy.

title: In vitro Antifungal Activity of Ravuconazole Against Isolates of Dermatophytes and Candida Species from XXXX with @entity9202 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Coronary saphenous vein grafts in @entity1 beings have a more limited long-term patency rate than internal thoracic artery grafts, primarily because of more rapid development of @entity4288 . The factors responsible for this increased susceptibility are not completely understood. To test the hypothesis that vein valves may influence this process, we studied 48 @entity753 @entity95 with jugular vein grafts interposed into the carotid arterial circulation. In 24 animals (group A), the vein segments did not contain a vein valve. In the other 24 animals (group B), a vein valve was present. Both groups were further divided in four subgroups of six to be put to death at 2, 4, 6, and 8 weeks after the operation. All animals were fed a 2% @entity165 diet. At postmortem examination, alternate 2 mm sections were either stained with @entity1710 and @entity1711 for histologic and morphometric studies or frozen in liquid @entity1568 for immunohistochemistry and in situ hybridization studies. Proliferating cell nuclear antigen immunostaining was used to study cell proliferation. Wall thickness of vein grafts increased with time. During the first 2 weeks intimal and medial thickening was primarily due to an increase in numbers of cells. Between 2 and 6 weeks further intimal and medial thickening occurred, but without additional increase in cell numbers. After 6 weeks, foam cells and lipid deposits started to appear. By 8 weeks, changes identical to those seen in arteriosclerotic plaques in @entity1 beings were evident. These changes developed sooner and with more intensity in group B animals (p < 0.01 to 0.001), and they developed faster and with more severity in segments of vein located distal to the valve than in the segments located proximal to the valve (p < 0.001). This is the first controlled experiment demonstrating that the presence of valves in the vein segments is associated with augmented and accelerated intimal changes leading to vein atheromatosis.

title: Influence of vein valves in the development of @entity4288 in venoarterial grafts in the XXXX .

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic']

entities_list: @entity4288 :: ('MESH:D001161', 'Disease') :: ['arteriosclerosis']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: Coronary saphenous vein grafts in @entity1 beings have a more limited long-term patency rate than internal thoracic artery grafts, primarily because of more rapid development of @entity4288 . The factors responsible for this increased susceptibility are not completely understood. To test the hypothesis that vein valves may influence this process, we studied 48 @entity753 @entity95 with jugular vein grafts interposed into the carotid arterial circulation. In 24 animals (group A), the vein segments did not contain a vein valve. In the other 24 animals (group B), a vein valve was present. Both groups were further divided in four subgroups of six to be put to death at 2, 4, 6, and 8 weeks after the operation. All animals were fed a 2% @entity165 diet. At postmortem examination, alternate 2 mm sections were either stained with @entity1710 and @entity1711 for histologic and morphometric studies or frozen in liquid @entity1568 for immunohistochemistry and in situ hybridization studies. Proliferating cell nuclear antigen immunostaining was used to study cell proliferation. Wall thickness of vein grafts increased with time. During the first 2 weeks intimal and medial thickening was primarily due to an increase in numbers of cells. Between 2 and 6 weeks further intimal and medial thickening occurred, but without additional increase in cell numbers. After 6 weeks, foam cells and lipid deposits started to appear. By 8 weeks, changes identical to those seen in arteriosclerotic plaques in @entity1 beings were evident. These changes developed sooner and with more intensity in group B animals (p < 0.01 to 0.001), and they developed faster and with more severity in segments of vein located distal to the valve than in the segments located proximal to the valve (p < 0.001). This is the first controlled experiment demonstrating that the presence of valves in the vein segments is associated with augmented and accelerated intimal changes leading to vein atheromatosis.

title: Influence of vein valves in the development of XXXX in venoarterial grafts in the @entity95 .

answer: @entity4288 :: (MESH:D001161,Disease) :: ['arteriosclerosis']


abstract: We tested the hypothesis that @entity528 in subjects at risk of @entity161 (1), as reflected by midbrain hyperechogenicity (2) and @entity191 @entity73 (3), is asymmetric and influenced by sex. We evaluated 62 subjects with never-treated chronic @entity161 , 80 of their adult, unaffected first degree relatives and 62 healthy controls (matched by sex and age to the cases), part of an Andean population of Northern Argentina. @entity304 was scored blindly using UPDRS-3 (Unified @entity191 Rating Scale) on videotaped exams by 2 independent raters. Transcranial ultrasound was performed by an expert sonographist blind to subject condition with a 2.5 MHz transducer through a temporal bone window. Quantification of echogenic area was carried out on saved images by a different evaluator. We found a significant difference in @entity191 @entity73 between @entity1 , their relatives as well as controls. All three groups showed worse @entity304 on the left side than the right, corresponding with increased echogenicity on the right substantia nigra compared with the left. Females had significantly more right echogenicity than males, and @entity1 and unaffected relatives were significantly more echogenic than controls on that side. On the left, only female @entity1 had significant echogenicity. Our data supports the notion that unaffected relatives of @entity161 subjects have increased @entity304 and concomitant @entity854 which may represent a vulnerability to the disease. Both motor and @entity854 are asymmetric and influenced by sex.

title: Sex and laterality differences in parkinsonian impairment and transcranial ultrasound in never-treated XXXX and their first degree relatives in an Andean population.

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinsonism', 'parkinsonism']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['motor impairment']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's Disease", 'parkinsonian']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['brainstem abnormalities']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'schizophrenic']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['loss of substantia nigra neurons']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenics']


abstract: In a three-month retrospective study, we assessed the proportion of rapid response team (RRT) calls associated with @entity1850 ( @entity1850 ) and @entity295 . We also documented the site of @entity281 (whether it was community- or hospital-acquired), antibiotic modifications after the call and in-hospital outcomes. Amongst 358 RRT calls, two or more @entity1850 criteria were present in 277 (77.4%). Amongst the 277 RRT calls with @entity1850 criteria, 159 (57.4%) fulfilled @entity295 criteria in the 24 hours before and 12 hours after the call. There were 118 of 277 (42.6%) calls with @entity1850 criteria but no evidence of @entity295 and 62 of 277 (22.3%) calls associated with both criteria for @entity295 as well as an alternative cause for @entity1850 . Hence, 159 (44.4%) of all 358 RRT calls over the three-month study period fulfilled criteria for @entity295 and in 97 (159-62) (27.1%) of the 358 calls, there were criteria for @entity295 without other causes for @entity1850 criteria. The most common sites of @entity281 were respiratory tract (86), abdominal cavity (38), urinary tract (26) and bloodstream (26). Infection was hospital-acquired in 91 (57.2%) and community-acquired in 67 (42.1%) cases, respectively. @entity1 were on antibiotics in 127 of 159 (79.9%) cases before the RRT call and antibiotics were added or modified in 76 of 159 (47.8%) cases after RRT review. The hospital length-of-stay of @entity1 who received an RRT call associated with @entity295 was longer than those who did not (16.0 [8.0 to 28.5] versus 10 days [6.0 to 18.0]; P=0.002).

title: The epidemiology of XXXX during rapid response team reviews in a teaching hospital.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1850 :: ('MESH:D018746', 'Disease') :: ['systemic inflammatory response syndrome', 'SIRS']

answer: @entity295 :: (MESH:D018805,Disease) :: ['sepsis']


abstract: BACKGROUND/PURPOSE: Betel quid (BQ) chewing is popular in Taiwan and many other countries. There are about 200-600 million BQ chewers in the world. BQ chewing is one major risk factor of @entity5 and @entity2345 ( @entity2345 ). While areca nut (AN), a main component of BQ, exhibits genotoxicity, its transformation capacity and its role in the initiation and promotion stages of @entity105 are not fully clear. METHODS: @entity19 C3H10T1/2 cells were exposed to AN extract (ANE) for 24 hours. @entity137 was evaluated by colony forming efficiency. For the transformation assay, C3H10T1/2 cells were exposed to ANE for 24 hours and then incubated in medium with/without 12-O-tetradecanolylphorbol-13-acetate (TPA; a @entity5 promoter) for 42 days. Cells were stained with Giemsa and type II and type III transformed foci were counted for analysis of the transformation capacity of ANE. RESULTS: ANE exhibited @entity137 to C3H10T/12 cells at concentrations higher than 320   g/mL as shown by a decrease in colony numbers. ANE (80-640   g/mL) alone mildly stimulated the transformed foci formation (p  >  0.05). In the presence of TPA, ANE (80-640   g/mL) markedly stimulated the transformed foci formation. The percentage of dishes with foci increased from 0% in controls to 20% in ANE (80   g/mL and 320   g/mL)-treated groups and further increased to 65-94% in ANE plus TPA groups. CONCLUSION: These results indicate that ANE is a weak complete carcinogen. ANE is an effective @entity5 initiator and can induce malignant transformation of C3H10T1/2 cells in the presence of a @entity5 promoter. ANE may be involved in multistep chemical @entity105 by its malignant transformation capacity.

title: XXXX and transformation of C3H10T1/2 cells induced by areca nut components.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Cytotoxicity', 'cytotoxicity']

entities_list: @entity2345 :: ('MESH:D009914', 'Disease') :: ['OSF', 'oral submucous fibrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'oral cancer']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

answer: @entity137 :: (MESH:D064420,Disease) :: ['Cytotoxicity']


abstract: AIM: To evaluate the relationship between @entity157 ( @entity157 ) vascularity and grade; to describe patterns and vascular/histopathological variations of post-transplantation recurrence. METHODS: This retrospective study included 165 @entity1 (143 @entity1 , 22 @entity1 ; median age 56.8 years, range 28-70.4 years) transplanted for @entity157 who had a follow-up period longer than 2 mo. Pre-transplantation dynamic computed tomography or magnetic resonance examinations were retrospectively reviewed, classifying @entity157 imaging enhancement pattern into hypervascular and hypovascular based on presence of wash-in during arterial phase. All pathologic reports of the explanted livers were reviewed, collecting data about @entity157 differentiation degree. The association between imaging vascular pattern and pathological grade was estimated using the Fisher exact test. All follow-up clinical and imaging data were reviewed for evidence of recurrence. Recurrence rate was calculated and imaging features of recurrent @entity5 were collected, classifying early and late recurrences based on timing (< or >=  2 years after transplantation) and intrahepatic, extrahepatic and both intrahepatic and extrahepatic recurrences based on location. All intrahepatic recurrences were classified as hypervascular or hypovascular and the differentiation degree was collected where available. The presence of variations in imaging enhancement pattern and pathological grade between the @entity5 and the intrahepatic recurrence was evaluated and the association between imaging and histopatholgical variations was estimated by using the   (2) test. RESULTS: Of the 163 @entity1 with imaging evidence of viable @entity5 , 156 (95.7%) had hypervascular and 7 (4.3%) @entity157 . Among the 125 @entity1 with evidence of viable @entity5 in the explanted liver, 19 (15.2%) had grade 1, 56 (44.8%) grade 2, 40 (32%) grade 3 and 4 (3.2%) grade 4 @entity157 , while the differentiation degree was not assessable for 6 @entity1 (4.8%). A significant association was found between imaging vascularity and pathological grade (P = 0.035). Post-transplantation recurrence rate was 14.55% (24/165). All recurrences occurred in @entity1 who had a hypervascular @entity5 . Three @entity1 (12.5%) experienced late recurrence; the location of the first recurrence was extrahepatic in 14 @entity1 (58.3%), intrahepatic in 7 @entity1 (29.2%) and both intrahepatic and extrahepatic in 3 @entity1 (12.5%). Two @entity1 had a variation in imaging characteristics between the primary @entity157 (hypervascular) and the intrahepatic recurrent @entity157 (hypovascular), while 1 @entity1 had a variation of histopathological characteristics (from moderate to poor differentiation), however no association was found between imaging and histopathological variations. CONCLUSION: A correlation was found between @entity157 grade and vascularity; some degree of variability may exist between the primary and the recurrence imaging/histopathological characteristics, apparently not correlated.

title: XXXX recurrence: Patterns and relation between vascularity and differentiation degree.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hypovascular HCC', 'hepatocellular carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor']

answer: @entity157 :: (MESH:D006528,Disease) :: ['Post-transplantation hepatocellular carcinoma']


abstract: OBJECTIVES: @entity810 ( @entity810 ), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized @entity1 . @entity8 -reperfusion, one of the main causes of @entity810 , is of particular importance in the setting of kidney transplantation. MATERIALS AND METHODS: Sixty male @entity35 were divided into four groups including control, nephrectomy, sham surgery and @entity8 -reperfusion (IRI) group. The @entity35 were anesthetized with intraperitonealketamin and xylazin. For making IRI group, right nephrectomywas performed, and after a week, the left kidney pedicle was occluded for 45 min for making @entity63 that followed by 24 hr reperfusion. At the end of reperfusion phase, the lung tissues were isolated to be used in immunohistochemical and histological assays. Immunohistochemical assay was used to evaluate @entity1976 and @entity1505 , and @entity1710 - @entity1711 staining assay was used to histopathology. RESULTS: lung tissues injury after @entity8 -reperfusion was revealed by immunohistochemistry analysis to increase @entity1505 level and decrease @entity1976 (an anti-apoptotic protein) level. @entity651 and @entity39 was discovered by @entity1710 - @entity1711 staining to be more evident in IRI group than sham and control groups. CONCLUSION: The results demonstrated that increase in @entity1505 and decrease in @entity1976 levels in lungs induces the pulmonary inflammatory damage in renal IRI model.

title: Effect of XXXX -reperfusion on @entity651 and inflammatory responses in male @entity35 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal ischemia', 'renal ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity651 :: ('MESH:D055370', 'Disease') :: ['Lung injury']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'Acute kidney injury']

answer: @entity8 :: (MESH:D007674,Disease) :: ['renal ischemia']


abstract: OBJECTIVES: @entity810 ( @entity810 ), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized @entity1 . @entity8 -reperfusion, one of the main causes of @entity810 , is of particular importance in the setting of kidney transplantation. MATERIALS AND METHODS: Sixty male @entity35 were divided into four groups including control, nephrectomy, sham surgery and @entity8 -reperfusion (IRI) group. The @entity35 were anesthetized with intraperitonealketamin and xylazin. For making IRI group, right nephrectomywas performed, and after a week, the left kidney pedicle was occluded for 45 min for making @entity63 that followed by 24 hr reperfusion. At the end of reperfusion phase, the lung tissues were isolated to be used in immunohistochemical and histological assays. Immunohistochemical assay was used to evaluate @entity1976 and @entity1505 , and @entity1710 - @entity1711 staining assay was used to histopathology. RESULTS: lung tissues injury after @entity8 -reperfusion was revealed by immunohistochemistry analysis to increase @entity1505 level and decrease @entity1976 (an anti-apoptotic protein) level. @entity651 and @entity39 was discovered by @entity1710 - @entity1711 staining to be more evident in IRI group than sham and control groups. CONCLUSION: The results demonstrated that increase in @entity1505 and decrease in @entity1976 levels in lungs induces the pulmonary inflammatory damage in renal IRI model.

title: Effect of @entity8 -reperfusion on XXXX and inflammatory responses in male @entity35 .

answer: @entity651 :: (MESH:D055370,Disease) :: ['lung injury']


abstract: OBJECTIVES: @entity810 ( @entity810 ), a syndrome characterized by decreased glomerular filtration, occurs in every 1 of 5 hospitalized @entity1 . @entity8 -reperfusion, one of the main causes of @entity810 , is of particular importance in the setting of kidney transplantation. MATERIALS AND METHODS: Sixty male @entity35 were divided into four groups including control, nephrectomy, sham surgery and @entity8 -reperfusion (IRI) group. The @entity35 were anesthetized with intraperitonealketamin and xylazin. For making IRI group, right nephrectomywas performed, and after a week, the left kidney pedicle was occluded for 45 min for making @entity63 that followed by 24 hr reperfusion. At the end of reperfusion phase, the lung tissues were isolated to be used in immunohistochemical and histological assays. Immunohistochemical assay was used to evaluate @entity1976 and @entity1505 , and @entity1710 - @entity1711 staining assay was used to histopathology. RESULTS: lung tissues injury after @entity8 -reperfusion was revealed by immunohistochemistry analysis to increase @entity1505 level and decrease @entity1976 (an anti-apoptotic protein) level. @entity651 and @entity39 was discovered by @entity1710 - @entity1711 staining to be more evident in IRI group than sham and control groups. CONCLUSION: The results demonstrated that increase in @entity1505 and decrease in @entity1976 levels in lungs induces the pulmonary inflammatory damage in renal IRI model.

title: Effect of @entity8 -reperfusion on @entity651 and inflammatory responses in male XXXX .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: PURPOSE: Selection of @entity1 with @entity385 for MRI that is suitable for thrombolytic therapy as an emerging application. Although the efficiency of the therapy with i.v. @entity1456 (tPA) within 3 hours after onset of symptoms has been proven in selected @entity1 with CT, now these criteria are determined by MRI, as the data we gather are fast and accurate in the first hours. MATERIAL AND METHODS: MRI screening in @entity1 with acute @entity385 before application of thrombolytic therapy was done in a UCC Mannheim in Germany. Unlike trials with CT, MRI studies demonstrated the benefits of therapy up to 6 hours after the onset of symptoms. We studied 21 @entity1 hospitalized in Clinic of Neuroradiology at University Clinical Centre in Mannheim-Germany. They all undergo brain MRI evaluation for @entity64 . This article reviews literature that has followed application of thrombolysis in @entity1 with @entity385 based on MRI. RESULTS: We have analyzed the MRI criteria for i.v. application of tPA at this University Centre. Alongside the personal viewpoints of clinicians, survey reveals a variety of clinical aspects and MRI features that are opened for further more exploration: therapeutic effects, the use of the MRI angiography, dynamics, and other. CONCLUSIONS: MRI is a tested imaging method for rapid evaluation of @entity1 with hyperacute @entity385 , replacing the use of CT imaging and clinical features. MRI criteria for thrombolytic therapy are being applied in some cerebral vascular centres. In Kosovo, the application of thrombolytic therapy has not started yet.

title: Magnetic resonance imaging criteria for thrombolysis in hyperacute XXXX .

entities_list: @entity1456 :: ('100128998', 'Gene') :: ['tissue plasminogen activator']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity385 :: (MESH:D002544,Disease) :: ['cerebral infarction']


abstract: BACKGROUND: Surgical wound @entity281 is an important complication of spinal surgery. Antibiotic prophylaxis has served to decrease its rates significantly, with the ensuing reduction in hospital stay, costs, and morbidity and mortality. To date, a large assessment of the degree of compliance with antibiotic prophylaxis in spinal fusion surgery has not been undertaken in Spain with large prospective studies. We sought to assess the degree of compliance with our antibiotic prophylaxis protocol among @entity1 who underwent spinal fusion surgery and its effect on @entity6081 . MATERIAL AND METHODS: A prospective cohort study was carried out. Six hundred and forty @entity1 with at least 1-year clinical followup who underwent spinal fusion surgery were included. Percentage of administration and degree of compliance with protocol was studied. Both overall and the different aspects of prophylaxis received by @entity1 to those stipulated in the protocol in force at our hospital were compared. Percentages of compliance were assessed and the effect of prophylaxis compliance on the incidence of @entity281 was estimated using the Relative Risk. RESULTS: The study covered 640 @entity1 . Overall compliance with the protocol was 71.5% (95% CI = 67.9- 75.1). The most frequent cause of non-compliance with the protocol was the duration of recommended antibiotic prophylaxis (77.8%). Incidence of @entity6081 was 4.1% (95% CI: 2.5-5.5). No relationship was found between @entity6081 and antibiotic prophylaxis non-compliance (RR 0.92, 95% CI = 0.38-2.22). CONCLUSIONS: Compliance and administration of antibiotic prophylaxis were high. Surgical wound @entity281 rate was similar to those found in the literature although there is always room for improvement.

title: Compliance with antibiotic prophylaxis in spinal fusion surgery and XXXX .

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity6081 :: ('MESH:D013530', 'Disease') :: ['surgical wound infection']

answer: @entity6081 :: (MESH:D013530,Disease) :: ['surgical wound infection']


abstract: Germination and thermoinhibition in lettuce ( @entity12681 'Jianyexianfeng No. 1') seeds were investigated by a proteomic comparison among dry seeds, germinated seeds at 15  C, at 15  C after imbibition at 25  C for 48 h, or at 25  C in KNO3 (all sampled individually at germination), and ungerminated seeds at 25  C, a thermoinhibitory temperature. Before two-dimensional gel electrophoresis analysis, storage proteins (greater than 50% of total extractable protein) were removed by @entity968 precipitation, which significantly improved the detection of less abundant proteins on two-dimensional gels. A total of 108 protein spots were identified to change more than 2-fold (P<0.05) in abundance in at least one germination treatment. Nineteen proteins increasing and one protein decreasing in abundance during germination had higher abundance in germinated 15  C, 15  C after imbibition at 25  C for 48 h, and 25  C in KNO3 seeds than in ungerminated 25  C seeds. Gene expression of 12 of those proteins correlated well with the protein accumulation. @entity1853 metabolism, @entity1786 production, lipid mobilization, cell elongation, and detoxification of @entity3125 were revealed to be potentially related to lettuce seed germination and thermoinhibition. Accumulation of three proteins and expression of five genes participating in the @entity12308 ( @entity13094 ) pathway of @entity12307 biosynthesis correlated positively with seed germinability. Inhibition of this pathway by @entity5753 delayed seed germination and increased the sensitivity of germination to @entity2271 . @entity13094 pathway-derived products, cytokinins, partially reversed the @entity5753 inhibition of germination and released seed thermoinhibition at 25  C. We conclude that the @entity13094 pathway for @entity12307 biosynthesis is involved in lettuce seed germination and thermoinhibition.

title: Proteomic analysis of lettuce seed germination and thermoinhibition by sampling of individual seeds at germination and removal of storage proteins by XXXX fractionation.

entities_list: @entity2271 :: ('MESH:D000040', 'Chemical') :: ['abscisic acid']

entities_list: @entity12308 :: ('MESH:D008798', 'Chemical') :: ['mevalonate']

entities_list: @entity12307 :: ('CHEBI:24913', 'Chemical') :: ['isoprenoid']

entities_list: @entity1853 :: ('MESH:D008715', 'Chemical') :: ['Methionine']

entities_list: @entity12681 :: ('4236', 'Species') :: ['Lactuca sativa']

entities_list: @entity5753 :: ('MESH:D008148', 'Chemical') :: ['lovastatin']

entities_list: @entity3125 :: ('MESH:D000447', 'Chemical') :: ['aldehydes']

entities_list: @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol']

entities_list: @entity1786 :: ('MESH:C036216', 'Chemical') :: ['ethylene']

answer: @entity968 :: (MESH:D011092,Chemical) :: ['polyethylene glycol']


abstract: BACKGROUND: @entity3061 represent a number of rare conditions characterized by destruction and resorption of bone that is unrelated to @entity5 , @entity281 , or @entity130 . AIM: To characterize the periprocedural course of @entity1 with primary @entity3061 undergoing procedures that require anesthesia care. METHODS: The medical records database from our institution was searched from 1976 to 2013 to identify @entity1 with @entity3061 who received anesthesia care. We reviewed demographic characteristics, comorbidities, and perioperative course of @entity1 with different forms of primary @entity3061 . A systematic review of the literature was performed to identify reports describing the anesthetic management of @entity1 with these conditions. RESULTS: We identified 11 @entity1 with a primary @entity3061 who received 111 anesthetics. The @entity1 ' ages at the time of surgery ranged from 3 to 62  years. Difficult airway management was a common finding. On preoperative examination, difficulty with endotracheal intubation was predicted in 8 of 11 @entity1 . Three @entity1 had preexisting tracheostomies. One @entity1 required multiple awake fiberoptic intubations. Another two @entity1 where successfully intubated early in life via direct laryngoscopy, but eventually required awake fiberoptic intubations as the disease process caused progressive distortion of airway structures. @entity3816 were absent. In the postoperative period, three @entity1 required prolonged mechanical ventilation due to airway swelling, @entity1576 , and @entity281 . CONCLUSIONS: Airway management may be challenging in @entity1 with @entity3061 . Because the osteolytic process advances with aging and craniofacial @entity4238 may progressively worsen, the airway should always be reassessed before surgery with an appropriate strategy for potentially difficult intubation. In all @entity1 with primary @entity3061 , a potential for pathologic fracture must be considered and careful intraoperative positioning is warranted.

title: XXXX : beware of difficult airway.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia']

entities_list: @entity3061 :: ('MESH:D010014', 'Disease') :: ['osteolysis', 'Primary osteolysis syndromes', 'primary osteolysis syndromes', 'osteolysis syndrome']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity4238 :: ('MESH:D057215', 'Disease') :: ['dysmorphism']

entities_list: @entity3816 :: ('MESH:D007431', 'Disease') :: ['Intraoperative complications']

answer: @entity3061 :: (MESH:D010014,Disease) :: ['Primary osteolysis syndromes']


abstract: During embryonic development, the components of the avian immune system undergo ontogeny in several distinct organs, including the bone marrow, spleen, thymus, and bursa of Fabricius. This process is regulated and controlled by the complex interactions of various cytokines and colony-stimulating factors (CSF). The objective was to examine the action of two different sources of @entity1583 growth factors, @entity558 ( @entity558 ) and @entity1573 embryo extract (CEE), on the proliferation of @entity1583 cells from various organs and on the differentiation of progenitor cells in semi-solid culture. Spleen and bone marrow cells obtained at Day 16 of incubation responded in a dose-dependent manner to the addition of @entity558 and CEE alone or in combination. No proliferative effect of @entity558 was observed on cells obtained from @entity6732 . Clonal analysis of bone marrow and spleen cells suggested that CEE may contain the avian equivalents of @entity30310 , @entity71628 , granulocyte-macrophage CSF, granulocyte-CSF, and macrophage-CSF. Clonal analysis of @entity558 cultures suggested that in addition to myelomonocytic growth factor, which affects primarily macrophage-granulocyte lineages, a thrombocyte-CSF-like activity was also apparent. The @entity558 alone tended to act upon committed late progenitors. The combination of CEE and @entity558 amplified the size and the total number of colonies obtained and appeared to act synergistically upon progenitors with a high level of proliferative potential. This response on young progenitors was confirmed when cells were cultured in CEE and @entity558 prior to clonal analysis. These results document the presence of thrombocyte CSF in @entity558 and the effect of both CEE and @entity558 on the proliferative differentiation of avian embryonic @entity1583 progenitors.

title: Synergistic action of two sources of avian growth factors on proliferative differentiation of @entity1573 embryonic XXXX cells.

entities_list: @entity558 :: ('MESH:C536528', 'Disease') :: ['spleen-conditioned media', 'SCM']

entities_list: @entity6732 :: ('MESH:D013953', 'Disease') :: ['embryonic thymus or bursa']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic']

answer: @entity1583 :: (MESH:D019337,Disease) :: ['hematopoietic']


abstract: During embryonic development, the components of the avian immune system undergo ontogeny in several distinct organs, including the bone marrow, spleen, thymus, and bursa of Fabricius. This process is regulated and controlled by the complex interactions of various cytokines and colony-stimulating factors (CSF). The objective was to examine the action of two different sources of @entity1583 growth factors, @entity558 ( @entity558 ) and @entity1573 embryo extract (CEE), on the proliferation of @entity1583 cells from various organs and on the differentiation of progenitor cells in semi-solid culture. Spleen and bone marrow cells obtained at Day 16 of incubation responded in a dose-dependent manner to the addition of @entity558 and CEE alone or in combination. No proliferative effect of @entity558 was observed on cells obtained from @entity6732 . Clonal analysis of bone marrow and spleen cells suggested that CEE may contain the avian equivalents of @entity30310 , @entity71628 , granulocyte-macrophage CSF, granulocyte-CSF, and macrophage-CSF. Clonal analysis of @entity558 cultures suggested that in addition to myelomonocytic growth factor, which affects primarily macrophage-granulocyte lineages, a thrombocyte-CSF-like activity was also apparent. The @entity558 alone tended to act upon committed late progenitors. The combination of CEE and @entity558 amplified the size and the total number of colonies obtained and appeared to act synergistically upon progenitors with a high level of proliferative potential. This response on young progenitors was confirmed when cells were cultured in CEE and @entity558 prior to clonal analysis. These results document the presence of thrombocyte CSF in @entity558 and the effect of both CEE and @entity558 on the proliferative differentiation of avian embryonic @entity1583 progenitors.

title: Synergistic action of two sources of avian growth factors on proliferative differentiation of XXXX embryonic @entity1583 cells.

answer: @entity1573 :: (9031,Species) :: ['chick']


abstract: UNASSIGNED: @entity6910 -incompatible (ABOi) liver transplantation (LT) with deceased donor organs is performed occasionally when no @entity6910 -compatible (ABOc) graft is available. From 1996 to 2011, 61 ABOi LTs were performed in Oslo and Gothenburg. Median @entity1 age was 51 years (range 13-75); 33 @entity1 were transplanted on urgent indications, 13 had @entity5 -related indications, and 8 received ABOi grafts for urgent retransplantations. Median donor age was 55 years (range 10-86). Forty-four @entity1 received standard triple immunosuppression with @entity230 , @entity1140 , and @entity618 , and forty-four @entity1 received induction with @entity1199 antagonist or anti- @entity2225 antibody. Median follow-up time was 29 months (range 0-200). The 1-, 3, 5-, and 10-year Kaplan-Meier estimates of @entity1 - (PS) and graft survival (GS) were 85/71%, 79/57%, 75/55%, and 59/51%, respectively, compared to 90/87%, 84/79%, 79/73%, and 65/60% for all other LT recipients in the same period. The 1-, 3-, 5-, and 10-year GS for A2 grafts were 81%, 67%, 62%, and 57%. In conclusion, ABOi LT performed with non-A2 grafts is associated with inferior graft survival and increased risk of rejection, vascular and biliary complications. ABOi LT with A2 grafts is associated with acceptable graft survival and can be used safely in urgent cases. This article is protected by copyright. All rights reserved.

title: Liver transplantation with deceased XXXX -incompatible donors is life-saving but associated with increased risk of rejection and post-transplant complications.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity6910 :: (28,Gene) :: ['ABO']


abstract: The present study was conducted to evaluate whether supplementation of semen extender with @entity2041 ( @entity6172 ) can maintain the quality of frozen-thawed @entity235 spermatozoa. Eighteen ejaculates were obtained from 5 @entity235 and placed in extender (20% egg yolk, Tris, @entity1792 , @entity1132 , @entity9592 , antibiotics and 6.5% @entity653 ) containing 0 (control), 2.5, 5, 7.5 or 10 mM @entity6172 . The samples were cooled to 4 C and then frozen in liquid @entity1568 vapor. Motility parameters of the sperm were evaluated at 0, 1, 2, 3, 4, 12 and 24 h after thawing. Sperm motility was higher in the 5 mM @entity6172 group than in the control or 2.5 and 10 mM @entity6172 groups; this effect was observed at 1 to 24 h after thawing (P < 0.05). The 5 mM @entity6172 group had a higher sperm viability index at 12 and 24 h after thawing compared with the other groups (P < 0.05). Acrosome integrity, evaluated at 4 h after thawing, was greater in two of the @entity6172 -treated groups (5 and 10 mM) compared with the control. Lipid peroxidation (LP) levels immediately after thawing were lower in the 5 and 10 mM @entity6172 groups compared with the control, while those at 12 h after thawing did not differ significantly. Frozen-thawed semen in the 5 mM @entity6172 group was used for transcervical insemination of 4 bitches, resulting in delivery of 5 puppies from 2 bitches. These results indicate that supplementation of semen extender with 5 mM @entity6172 was effective in improving motility, longevity and acrosomal integrity and inhibiting LP levels in post-thaw @entity235 spermatozoa, without any adverse impacts on full-term development after transcervical insemination.

title: XXXX supplementation to semen extender improves the quality of frozen-thawed @entity235 spermatozoa for transcervical insemination.

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity1792 :: ('MESH:D019343', 'Chemical') :: ['citric acid']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol']

entities_list: @entity9592 :: ('MESH:D011887', 'Chemical') :: ['raffinose']

answer: @entity2041 :: (MESH:D005978,Chemical) :: ['Glutathione']


abstract: The present study was conducted to evaluate whether supplementation of semen extender with @entity2041 ( @entity6172 ) can maintain the quality of frozen-thawed @entity235 spermatozoa. Eighteen ejaculates were obtained from 5 @entity235 and placed in extender (20% egg yolk, Tris, @entity1792 , @entity1132 , @entity9592 , antibiotics and 6.5% @entity653 ) containing 0 (control), 2.5, 5, 7.5 or 10 mM @entity6172 . The samples were cooled to 4 C and then frozen in liquid @entity1568 vapor. Motility parameters of the sperm were evaluated at 0, 1, 2, 3, 4, 12 and 24 h after thawing. Sperm motility was higher in the 5 mM @entity6172 group than in the control or 2.5 and 10 mM @entity6172 groups; this effect was observed at 1 to 24 h after thawing (P < 0.05). The 5 mM @entity6172 group had a higher sperm viability index at 12 and 24 h after thawing compared with the other groups (P < 0.05). Acrosome integrity, evaluated at 4 h after thawing, was greater in two of the @entity6172 -treated groups (5 and 10 mM) compared with the control. Lipid peroxidation (LP) levels immediately after thawing were lower in the 5 and 10 mM @entity6172 groups compared with the control, while those at 12 h after thawing did not differ significantly. Frozen-thawed semen in the 5 mM @entity6172 group was used for transcervical insemination of 4 bitches, resulting in delivery of 5 puppies from 2 bitches. These results indicate that supplementation of semen extender with 5 mM @entity6172 was effective in improving motility, longevity and acrosomal integrity and inhibiting LP levels in post-thaw @entity235 spermatozoa, without any adverse impacts on full-term development after transcervical insemination.

title: @entity2041 supplementation to semen extender improves the quality of frozen-thawed XXXX spermatozoa for transcervical insemination.

answer: @entity235 :: (9615,Species) :: ['canine']