abstract: OBJECTIVE: To study clinical effects of inversive @entity3 ( @entity3 , @entity3 ) plate combined with steel wire for the treatment of @entity3330 . METHODS: From January 2009 to Janurary 2012, 11 @entity1 with @entity3330 were treated with inversive @entity3 plate combined with steel wire, including 8 males and 3 females, ranging in age from 35 to 61 years old (averaged, 51 years old). Causes of injury: 8 @entity1 caused by accident and 3 @entity1 caused by falling down. According to X-ray examination, all the @entity1 were @entity3330 and were treated with @entity3 plate combined with steel wire. Merle d'Aubigne scores were used to evaluate therapeutic effects on hip. RESULTS: The mean period of follow-up was 16 months (ranged, 12 to 28 months). All the @entity1 obtained bone union for average 3.8 months (ranged from 3 to 4.3 months). There were no complications such as @entity281 , @entity1150 , @entity1151 and bone nonunion. According to Merle d'Aubigne scores, 7 @entity1 got an excellent result and 4 good. CONCLUSION: Inversive @entity3 plate combined with steel wire for the treatment of @entity3330 is satisfactory, Which can provide stable fixation for @entity174 end and provide an ideal internal fixation method for treatment of this kind of @entity174 in the future.

title: [Treatment of XXXX with inversive @entity3 plate combined with steel wire].

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['deep infection']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['less invasive stabilization system', 'LISS']

entities_list: @entity3330 :: ('MESH:D005264', 'Disease') :: ['Seinsheimer type V subtrochanteric femoral fractures', 'type V subtrochanteric femoral fractures']

answer: @entity3330 :: (MESH:D005264,Disease) :: ['Seinsheimer type V subtrochanteric femoral fractures']


abstract: OBJECTIVE: To study clinical effects of inversive @entity3 ( @entity3 , @entity3 ) plate combined with steel wire for the treatment of @entity3330 . METHODS: From January 2009 to Janurary 2012, 11 @entity1 with @entity3330 were treated with inversive @entity3 plate combined with steel wire, including 8 males and 3 females, ranging in age from 35 to 61 years old (averaged, 51 years old). Causes of injury: 8 @entity1 caused by accident and 3 @entity1 caused by falling down. According to X-ray examination, all the @entity1 were @entity3330 and were treated with @entity3 plate combined with steel wire. Merle d'Aubigne scores were used to evaluate therapeutic effects on hip. RESULTS: The mean period of follow-up was 16 months (ranged, 12 to 28 months). All the @entity1 obtained bone union for average 3.8 months (ranged from 3 to 4.3 months). There were no complications such as @entity281 , @entity1150 , @entity1151 and bone nonunion. According to Merle d'Aubigne scores, 7 @entity1 got an excellent result and 4 good. CONCLUSION: Inversive @entity3 plate combined with steel wire for the treatment of @entity3330 is satisfactory, Which can provide stable fixation for @entity174 end and provide an ideal internal fixation method for treatment of this kind of @entity174 in the future.

title: [Treatment of @entity3330 with inversive XXXX plate combined with steel wire].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity3 :: (MESH:D009362,Disease) :: ['LISS']


abstract: @entity14660 ( @entity14660 ) and @entity14661 ( @entity14661 ) are the major hyaluronidases acting synergistically to degrade @entity8273 ( @entity8273 ). In the kidney, @entity8273 is distributed heterogeneously. Our goal was to determine the consequences of a lack of either @entity14660 or @entity14661 (using specific knockout @entity19 ) on renal function and on @entity8 . Experiments were performed in @entity14660 (-/-) and @entity14661 (-/-) @entity19 and in their wild-type controls. @entity8273 concentration was measured in the plasma and kidney tissue and its distribution through the different kidney zones was examined by immunohistochemistry. Relative mRNA expressions of @entity14660 , @entity14661 and the 3 main @entity8273 synthases were evaluated by quantitative RT-PCR. RESULTS: Kidney function was not impaired in the knockout @entity19 but they displayed elevated @entity8273 concentrations in the plasma and in the kidney. @entity14660 (-/-) @entity19 presented an accumulation of @entity8273 inside the proximal tubular cells whereas @entity14661 (-/-) @entity19 showed @entity8273 accumulation in the interstitial space. In the cortex and in the outer medulla, @entity14660 mRNA expression was up-regulated in @entity14661 (-/-) @entity19 . From our study we conclude that somatic hyaluronidases are not required for renal function. However, @entity14660 is necessary for the breakdown of intracellular @entity8273 in the cortex, whereas @entity14661 is essential for the degradation of extracellular @entity8273 in all kidney regions.

title: @entity14660 and @entity14661 are required for XXXX .

entities_list: @entity8273 :: ('MESH:C565742', 'Disease') :: ['HA', 'hyaluronan']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal HA accumulation']

answer: @entity8 :: (MESH:D007674,Disease) :: ['renal hyaluronan turnover']


abstract: @entity14660 ( @entity14660 ) and @entity14661 ( @entity14661 ) are the major hyaluronidases acting synergistically to degrade @entity8273 ( @entity8273 ). In the kidney, @entity8273 is distributed heterogeneously. Our goal was to determine the consequences of a lack of either @entity14660 or @entity14661 (using specific knockout @entity19 ) on renal function and on @entity8 . Experiments were performed in @entity14660 (-/-) and @entity14661 (-/-) @entity19 and in their wild-type controls. @entity8273 concentration was measured in the plasma and kidney tissue and its distribution through the different kidney zones was examined by immunohistochemistry. Relative mRNA expressions of @entity14660 , @entity14661 and the 3 main @entity8273 synthases were evaluated by quantitative RT-PCR. RESULTS: Kidney function was not impaired in the knockout @entity19 but they displayed elevated @entity8273 concentrations in the plasma and in the kidney. @entity14660 (-/-) @entity19 presented an accumulation of @entity8273 inside the proximal tubular cells whereas @entity14661 (-/-) @entity19 showed @entity8273 accumulation in the interstitial space. In the cortex and in the outer medulla, @entity14660 mRNA expression was up-regulated in @entity14661 (-/-) @entity19 . From our study we conclude that somatic hyaluronidases are not required for renal function. However, @entity14660 is necessary for the breakdown of intracellular @entity8273 in the cortex, whereas @entity14661 is essential for the degradation of extracellular @entity8273 in all kidney regions.

title: @entity14660 and XXXX are required for @entity8 .

answer: @entity14661 :: (15587(Tax:10090),Gene) :: ['hyaluronidase 2']


abstract: @entity14660 ( @entity14660 ) and @entity14661 ( @entity14661 ) are the major hyaluronidases acting synergistically to degrade @entity8273 ( @entity8273 ). In the kidney, @entity8273 is distributed heterogeneously. Our goal was to determine the consequences of a lack of either @entity14660 or @entity14661 (using specific knockout @entity19 ) on renal function and on @entity8 . Experiments were performed in @entity14660 (-/-) and @entity14661 (-/-) @entity19 and in their wild-type controls. @entity8273 concentration was measured in the plasma and kidney tissue and its distribution through the different kidney zones was examined by immunohistochemistry. Relative mRNA expressions of @entity14660 , @entity14661 and the 3 main @entity8273 synthases were evaluated by quantitative RT-PCR. RESULTS: Kidney function was not impaired in the knockout @entity19 but they displayed elevated @entity8273 concentrations in the plasma and in the kidney. @entity14660 (-/-) @entity19 presented an accumulation of @entity8273 inside the proximal tubular cells whereas @entity14661 (-/-) @entity19 showed @entity8273 accumulation in the interstitial space. In the cortex and in the outer medulla, @entity14660 mRNA expression was up-regulated in @entity14661 (-/-) @entity19 . From our study we conclude that somatic hyaluronidases are not required for renal function. However, @entity14660 is necessary for the breakdown of intracellular @entity8273 in the cortex, whereas @entity14661 is essential for the degradation of extracellular @entity8273 in all kidney regions.

title: XXXX and @entity14661 are required for @entity8 .

answer: @entity14660 :: (15586(Tax:10090),Gene) :: ['Hyaluronidase 1']


abstract: BACKGROUND: @entity834 is associated with higher rates of recurrence after surgery for @entity14 . However, the mechanisms responsible are unknown. The aim was to investigate the inflammatory and angiogenic responses in @entity1 undergoing surgery for @entity14 who had @entity1320 , and to compare the results with @entity1 without complications. METHODS: Consecutive @entity1 undergoing surgery for @entity14 with curative intent were included. @entity1 who had an @entity834 or @entity6177 were included in the @entity281 group and matched with @entity1 who had an uncomplicated postoperative course. @entity650 and @entity7 were measured in serum and peritoneal fluid. RESULTS: Serum concentration of @entity650 was higher in the @entity281 group (n  =  30) compared with the control group (n  =  30) on day 4 ( @entity281 : 42.3 [27.6-1473.2] versus control: 0.6 [0.6-17.1]  pg/ml; p  =  0.008). @entity650 in peritoneal fluid was higher in the @entity281 group at 48  h and day 4 ( @entity281 : 1000.2 [995.4-1574.0] versus control: 90.3 [35.2.6-106.1]  pg/ml; p  =  0.001). Serum @entity7 was higher in the @entity281 group on day 4 ( @entity281 : 1128.6 [427.3-10000.0] versus control: 438.3 [214.1-677.6]  pg/ml; p  =  0.001). Peritoneal @entity7 concentration was higher in the @entity281 group at 48  h and day 4 ( @entity281 : 10000.0 [2563.0-10000.0] versus control: 477.8 [313.5-814.4]  pg/ml; p  =  0.001). Two-year recurrence rate was higher in @entity1 with @entity281 ( @entity281 : 30% versus control: 4%; p  =  0.001). CONCLUSIONS: @entity1320 increases @entity650 and @entity7 after surgery for @entity14 . Amplification of @entity32 and angiogenesis might be one of the mechanisms responsible for the higher recurrence rate observed in @entity1 with @entity834 or @entity6177 .

title: XXXX and @entity14 recurrence: A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leak', 'Anastomotic leakage', 'anastomotic leakage']

entities_list: @entity6177 :: ('MESH:D018784', 'Disease') :: ['intra-abdominal abscess']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['Intra-abdominal infection', 'postoperative intra-abdominal infection']

answer: @entity1320 :: (MESH:D059413,Disease) :: ['Postoperative intra-abdominal infection']


abstract: BACKGROUND: @entity834 is associated with higher rates of recurrence after surgery for @entity14 . However, the mechanisms responsible are unknown. The aim was to investigate the inflammatory and angiogenic responses in @entity1 undergoing surgery for @entity14 who had @entity1320 , and to compare the results with @entity1 without complications. METHODS: Consecutive @entity1 undergoing surgery for @entity14 with curative intent were included. @entity1 who had an @entity834 or @entity6177 were included in the @entity281 group and matched with @entity1 who had an uncomplicated postoperative course. @entity650 and @entity7 were measured in serum and peritoneal fluid. RESULTS: Serum concentration of @entity650 was higher in the @entity281 group (n  =  30) compared with the control group (n  =  30) on day 4 ( @entity281 : 42.3 [27.6-1473.2] versus control: 0.6 [0.6-17.1]  pg/ml; p  =  0.008). @entity650 in peritoneal fluid was higher in the @entity281 group at 48  h and day 4 ( @entity281 : 1000.2 [995.4-1574.0] versus control: 90.3 [35.2.6-106.1]  pg/ml; p  =  0.001). Serum @entity7 was higher in the @entity281 group on day 4 ( @entity281 : 1128.6 [427.3-10000.0] versus control: 438.3 [214.1-677.6]  pg/ml; p  =  0.001). Peritoneal @entity7 concentration was higher in the @entity281 group at 48  h and day 4 ( @entity281 : 10000.0 [2563.0-10000.0] versus control: 477.8 [313.5-814.4]  pg/ml; p  =  0.001). Two-year recurrence rate was higher in @entity1 with @entity281 ( @entity281 : 30% versus control: 4%; p  =  0.001). CONCLUSIONS: @entity1320 increases @entity650 and @entity7 after surgery for @entity14 . Amplification of @entity32 and angiogenesis might be one of the mechanisms responsible for the higher recurrence rate observed in @entity1 with @entity834 or @entity6177 .

title: @entity1320 and XXXX recurrence: A prospective matched cohort study of inflammatory and angiogenic responses as mechanisms involved in this association.

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: The present paper's main work is firstly preparing a single layer and a large area @entity852 microspheres mask, with 117, 350 and 500 nm in diameter, and then depositing a layer of @entity1947 thin film on the mask board by RF magnetron sputtering technique, using nanospheres lithography technique to remove the @entity852 spheres by soaking with @entity6188 , and two-dimensional @entity1947 nano-array samples were obtained at last. The samples were characterized on the morphology and composition by scanning electron microscopy and energy dispersive X-ray spectrometer. The results showed that the samples are @entity1947 nanocluster formed by ordered cellular reticular structures. By measuring with absorption spectroscopy in the range from 300 to 800 nm at room temperature, the absorption peak turns up with broadening and red shift with the increase in the diameter of @entity852 colloidal spheres, namely the nano-particles diameters. As the sputtering time increases, that is, the increase in the @entity1947 film thickness, the light absorption rate increases. In addition, theoretical calculation based on the theory of discrete dipole approximation was performed to simulate the optical absorption properties of the @entity1947 nanocluster arrays between 300 and 800 nm. Dipole approximation theory can be used to calculate the absorption of the particles of any shape and size. Currently, the theoretical calculation results of various shapes of nanostructured metals such as gold and @entity575 are consist ent with the experimental results. But the application of the theory of discrete dipole approximation calculation of @entity1948 nanoparticles was rarely reported. In this paper, this theory has been used to calculate the optical absorption properties of triangle-shaped @entity1948 nanoparticles array. Light absorption characteristics were simulated according to changes in the dielectric constant and thickness of @entity1947 films, and the results can be used to explain the experimental results.

title: [Research on the preparation and optical absorption properties of two-dimensional XXXX array].

entities_list: @entity852 :: ('MESH:D011137', 'Chemical') :: ['polystyrene']

entities_list: @entity6188 :: ('MESH:C018674', 'Chemical') :: ['tetrahydrofuran']

entities_list: @entity1947 :: ('MESH:D015034', 'Chemical') :: ['zinc oxide']

answer: @entity1948 :: (CHEBI:50836,Chemical) :: ['ZnO']


abstract: The clinical and laboratory features of 24 @entity1 with proven @entity3454 ( @entity3454 ) and @entity75 are reported. The age range of affected @entity1 was between 20 and 63 years (average of 43) and 70 percent were @entity1 . @entity3454 was documented prior to the @entity75 in only 4 @entity1 . The majority of @entity1 experienced bland @entity385 . Disorders also included transient @entity63 attacks, @entity1188 , parencymatous and @entity510 , @entity410 and @entity732 . Significant risk factors for @entity64 other than @entity3454 were lacking in the @entity1 group. Cerebral angiograms occasionally showed distal occlusions of small arteries suggesting @entity75 . Our study suggests that @entity3454 is a risk factor for @entity64 . We recommend echocardiography in @entity1 with @entity2806 who lack clear, recognized risk factors for @entity64 . We believe the basis for this @entity75 to be emboli from damaged mitral valve leaflets.

title: Brain events associated with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['embolic brain lesions', 'brain disorder', 'brain illness', 'brain dysfunction']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity3454 :: ('MESH:D008945', 'Disease') :: ['mitral valve prolapse', 'MVP']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['cerebellar infarctions']

entities_list: @entity732 :: ('MESH:D015356', 'Disease') :: ['retinal artery occlusion']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity3454 :: (MESH:D008945,Disease) :: ['mitral valve prolapse']


abstract: BACKGROUND: Traditionally, conservative breast surgery was contraindicated in centrally located @entity0 , with total mastectomy as the treatment of choice. However, restorations of the central defects by the oncoplastic volume displacement or replacement techniques have been shown to be effective. The aim of the current study was to assess the surgical outcome of oncoplastic techniques after central @entity0 resection. METHODS: Thirty @entity1 with central @entity0 , including two @entity1 with @entity4261 , treated at the Oncology Center of Mansoura University (Egypt) between June 2011 and December 2014 were included in this study. The oncoplastic techniques performed were Grisotti advancement rotational flap in eight (26.7  %) @entity1 , classic skin-sparing mastectomy (SSM) with latissimus dorsi pedicled flap in 20 (66.7  %) @entity1 , and skin-reducing mastectomy (SRM) with latissimus dorsi pedicled flap using wise pattern inverted T incision in two (6.7  %) @entity1 . The choice of the oncoplastic techniques depends on the achievement of free safety margins, the breast volume, and its ptotic degree. RESULTS: The median age was 40.5  years (range; 23-55). There were no major complications that require repeating the oncoplastic techniques. Recorded complications included wound @entity6783 (4/30, 13.3  %) donor site seroma (4/30, 13.3  %), and @entity281 (1/30, 3.3  %). The 6-month subjective @entity1 satisfaction was excellent in 21 (70  %) @entity1 , good in 6 (20  %) @entity1 , and fair in 3 (10  %) @entity1 . There was no episode of local recurrence or systemic @entity3 after an average follow-up duration of 24  months (range; 6-42). CONCLUSIONS: Restoring the central defect after resection of the central @entity0 can be safely achieved using oncoplastic procedures including the Grisotti technique or the design of SSM or SRM with immediate breast reconstruction. In our @entity1 , these procedures yield a satisfactory esthetic outcome with lower morbidity.

title: The outcome of oncoplastic techniques in defect reconstruction after resection of central XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'breast tumors']

entities_list: @entity4261 :: ('MESH:D010001', 'Disease') :: ['Paget disease']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['surgical site infection']

entities_list: @entity6783 :: ('MESH:D013529', 'Disease') :: ['dehiscence']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast tumors']


abstract: BACKGROUND: To examine possible associations between midregional proatrial natriuretic peptide (MR-proANP) and @entity6 complications at baseline and risk of mortality and @entity454 ( @entity454 ) during follow-up in type 1 @entity6 . METHODS: Observational study including 667 @entity1 , with plasma MR-proANP measured at baseline. Complications were defined as micro- (n = 168) or macroalbuminuria (n = 190) (urinary albumin excretion rate (UAER) 30-299 or >= 300mg/24h), previous @entity65 ( @entity65 ) (n = 143), cardiac @entity5433 (heart rate variability < 11 beats/min) (n = 369), and @entity989 (n = 523). Adjustments included gender, age, systolic blood pressure, estimated glomerular filtration rate (eGFR), UAER, HbA1c, total @entity165 , 24-hour urinary @entity1372 excretion (24h-UNa), body mass index, daily insulin dose, antihypertensive treatment, and smoking in linear regression analyses and analysis of covariance models. Development of @entity454 (dialysis, renal transplantation, or GFR/eGFR < 15ml/ @entity1009 .73 m(2)) and mortality was recorded through national registers. RESULTS: The cohort included 293 (44%) females, aged 55    13 years. Plasma MR-proANP (median (interquartile)) was 74.7 (49.2-116.8) pmol/L. Adjusted, MR-proANP correlated positively with age and UAER and negatively with eGFR, 24h-UNa, total @entity165 , and HbA1c (P < 0.05). Moreover, MR-proANP levels increased with @entity633 degree and were higher in @entity1 with previous @entity65 (P  <= 0.001), but similar in @entity1 with or without @entity5433 or @entity989 (P >=  0.076). During follow-up (3.5 (3.1-4.0) years), higher MR-proANP concentrations predicted @entity454 and mortality combined (n = 35) adjusted for gender, age, systolic blood pressure, eGFR, and previous @entity65 (hazard ratio per 1SD increase in logANP: 2.8 (1.6-4.7; P < 0.001)). CONCLUSIONS: Increased plasma MR-proANP was associated with @entity8 , increased @entity633 , and previous @entity65 . Moreover, MR-proANP concentrations were associated with increased risk of development of @entity454 and mortality combined during follow-up.

title: Increased Plasma Concentrations of Midregional Proatrial Natriuretic Peptide Is Associated With Risk of Cardiorenal Dysfunction in Type 1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['impaired renal function']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: The new life of a @entity1 being begins at the moment of fertilization, i.e. when an ovum and a sperm join together. From this moment on the fertilized egg has the capacity to achieve its complete development whether or not nidation takes place. Abortion means interruption of pregnancy through death of the fetus. Postcoital contraceptive agents are not contraceptive agents but abortifacient agents, since they intervene on an already fertilized egg. @entity2208 have usually pathological reasons, as do early deliveries. The majority of the so called therapeutic abortions are really induced abortions disguised under another name; the cases in which a new pregnancy can really be detrimental to the mother are, these days, extremely rare, and @entity146 indications for abortion are mostly excuses to free a @entity1 from an unwanted pregnancy. Moreover, it is precisely the mothers who have sought an abortion who often become affected by serious psychological problems. Contraceptive agents must be distinguished according to their mechanism of action; those which are really anovulatory agents, and those which are antiimplantation agents, and, as such, abortifacient agents. The mechanism of action of @entity6862 ( @entity7280 ) does inhibit ovulation; at times, however, it inhibits implantation either by modifying tubal or uterine contractility, or by causing endometrial changes. In this case even @entity6862 are abortifacient agents. The mechanism of action of all types of IUDs always leads to inhibition of nidation by modification of endometrial functions; as such, any IUD is an abortifacient agent. As international statistics can demonstrate the widespread use of contraception has not diminished the number of abortions; on the contrary the number has increased enormously. Obviously the step from contraception to abortion in case of contraception failure is a very short one.

title: [The rights of XXXX before birth].

entities_list: @entity2208 :: ('MESH:D000022', 'Disease') :: ['Spontaneous abortions']

entities_list: @entity7280 :: ('MESH:D003276', 'Chemical') :: ['oral contraceptives']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity1 :: (9606,Species) :: ['child']


abstract: BACKGROUND: @entity981 ( @entity981 ) with combined @entity7513 / @entity588 and MYC rearrangement are rare and their clinical, cytogenetic and immunophenotypic features are not well characterized. Here, we describe a case of a 61-year-old @entity1 with @entity981 associated with these cytogenetic alterations and present a review of the literature of this disease. METHODS: Four-color flow cytometry (FC) was performed on a BD FACSCanto II flow cytometer. Data were analyzed with BD FACSDiva software. Cytogenetic, fluorescence in situ hybridization (FISH), and molecular studies were performed by conventional methods. A review of the literature was performed by a PubMed-assisted search. RESULTS: Including our case, eight B-LBLs associated with a documented "double-hit" karyotype ( @entity7513 / @entity588 and 8q24/MYC rearrangement) were identified in the literature (male/female 2/6, age 15-65). Three occurred de-novo, and five had a history of a @entity2282 + @entity1892 . The typical immunophenotype was @entity2282 , @entity1075 , @entity10730 positive, and negative for @entity2280 and surface immunoglobulin (Ig), established either by flow cytometry or immunohistochemistry. Seven cases were @entity2225 -, and one case was @entity2225 +. Translocation partners of MYC varied, and included @entity7513 , lambda light chain, and an unknown gene on chromosome 9. Prognosis was poor with median survival of five months. CONCLUSIONS: @entity1 with @entity981 associated with a combined @entity7513 / @entity588 and MYC rearrangement often have a history of a mature @entity1892 . The immunophenotype of these cases is different from that of mature "double-hit" @entity706 ; FC is essential to differentiate the @entity981 cases from the leukemic phase of mature @entity1892 . This article is protected by copyright. All rights reserved.

title: Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined XXXX / @entity588 and MYC rearrangement.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'woman']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['B-LBL', 'B-lymphoblastic leukemias']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphomas', 'B-cell lymphoma']

answer: @entity7513 :: (3492,Gene) :: ['IGH']


abstract: BACKGROUND: @entity981 ( @entity981 ) with combined @entity7513 / @entity588 and MYC rearrangement are rare and their clinical, cytogenetic and immunophenotypic features are not well characterized. Here, we describe a case of a 61-year-old @entity1 with @entity981 associated with these cytogenetic alterations and present a review of the literature of this disease. METHODS: Four-color flow cytometry (FC) was performed on a BD FACSCanto II flow cytometer. Data were analyzed with BD FACSDiva software. Cytogenetic, fluorescence in situ hybridization (FISH), and molecular studies were performed by conventional methods. A review of the literature was performed by a PubMed-assisted search. RESULTS: Including our case, eight B-LBLs associated with a documented "double-hit" karyotype ( @entity7513 / @entity588 and 8q24/MYC rearrangement) were identified in the literature (male/female 2/6, age 15-65). Three occurred de-novo, and five had a history of a @entity2282 + @entity1892 . The typical immunophenotype was @entity2282 , @entity1075 , @entity10730 positive, and negative for @entity2280 and surface immunoglobulin (Ig), established either by flow cytometry or immunohistochemistry. Seven cases were @entity2225 -, and one case was @entity2225 +. Translocation partners of MYC varied, and included @entity7513 , lambda light chain, and an unknown gene on chromosome 9. Prognosis was poor with median survival of five months. CONCLUSIONS: @entity1 with @entity981 associated with a combined @entity7513 / @entity588 and MYC rearrangement often have a history of a mature @entity1892 . The immunophenotype of these cases is different from that of mature "double-hit" @entity706 ; FC is essential to differentiate the @entity981 cases from the leukemic phase of mature @entity1892 . This article is protected by copyright. All rights reserved.

title: Immunophenotypic and cytogenetic findings of B-lymphoblastic leukemia/lymphoma associated with combined @entity7513 / XXXX and MYC rearrangement.

answer: @entity588 :: (596,Gene) :: ['BCL2']


abstract: INTRODUCTION: Robot-assisted minimally invasive esophagectomy with intra-thoracic @entity254 showed encouraging results but there is a lack of data to demonstrate the safety and feasibility. OBJECTIVE: The aim of this study is to report our experience in RA-ILE (robotic-assisted Ivor-Lewis esophagectomy) with robotic hand-sewn @entity254 . METHODS: This is a retrospective study of @entity1 who underwent robotic-assisted esophagectomy in prone position with intrathoracic @entity254 for @entity5 of the esophagus or esophago-gastric junction. RESULTS: From January 2012 to December 2014 we performed eight completely robot-assisted esophagectomy without @entity532 . The mortality rate at 30-day was zero. In two @entity1 we observed a partial leakage of the gastric tube that required revision. The mean operative time was 499        46   min including robotic set up and @entity1 positioning. The median hospital-stay was 10   days. Complete (R0) resection was accomplished in all @entity1 and the mean number of lymph nodes removed was 37.6        14 .7. CONCLUSIONS: This preliminary experience suggests that robotic-assisted RA-ILE for @entity5 is a real surgical option compared with conventional surgery with satisfactory results. Copyright    2015 John Wiley _ Sons, Ltd.

title: Robot-sewn Ivor-Lewis XXXX : preliminary experience and technical details.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['intra-operative complication']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant lesions', 'malignant neoplasm']

answer: @entity254 :: (MESH:C563598,Disease) :: ['anastomosis']


abstract: UNASSIGNED: While chemotherapy is universally recognized as a frontline treatment strategy for @entity0 , it is not always successful; among the leading causes of treatment failure is existing and/or acquired multidrug resistance. @entity5 stem cells (CSCs), which constitute a minority of the cells of a @entity5 , are acknowledged to be responsible for increased resistance to chemo-drugs through a combination of increased expression of @entity855 -binding cassette transporters (ABC transporters), an increased anti-apoptotic defense, and/or the ability for extensive DNA repair like normal stem cells. Consequently, more effective therapy, especially targeted to CSCs, is urgently required. We studied the characteristics of 231-CSCs ( @entity1759 +/ @entity11707 -) sorted from @entity1 MDA-MB-231 @entity0 cells and demonstrated that 231-CSCs exhibited enhanced capacities for proliferation, migration, tumorigenesis and chemotherapy resistance. To address these multifunctional facets of CSCs, we devised a non-ionic surfactant-based vesicle (niosome) @entity262 to simultaneously deliver siRNAs, targeted to both the ABC transporter ( @entity10430 ) and the anti-apoptosis defense gene ( @entity588 ), and @entity632 ( @entity3105 ) to CSCs. The rationale is to sensitize CSCs to @entity3105 by down regulating the drug-resistance gene @entity10430 and simultaneously induce apoptosis by lowering @entity588 expression. The @entity262 ( @entity262 ) successfully delivered siRNAs and @entity3105 to the cytoplasm and nuclei, respectively, and resulted in a down-regulation of @entity10430 - and @entity588 mRNAs in CSCs by 60% and 65%, respectively, compared to the control. A corresponding decrease in protein expression was observed using Western blotting. The IC50 of @entity3105 in CSCs concurrently decreased significantly. Our result established @entity262 as a promising multi-drug delivery platform for @entity5 treatment.

title: Enhanced efficacy of chemotherapy for XXXX stem cells by simultaneous suppression of multidrug resistance and antiapoptotic cellular defense.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['co-delivery system', 'CDS']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: The @entity1 @entity989 ( @entity989 ) plays an important role in the pathogenesis of @entity1020 ( @entity1020 ). @entity1020 is the leading cause of @entity1939 worldwide. There is currently no effective treatment available. Preclinical studies in @entity1020 @entity19 models are essential to develop new therapeutics. This requires further in-depth knowledge of the similarities and differences between @entity19 and @entity1 @entity989 . METHODS: We performed a microarray study to identify and functionally annotate @entity989 specific gene expression in @entity19 and @entity1 @entity989 . We used a meticulous method to determine C57BL/6J @entity19 @entity989 signature genes, correcting for possible RNA contamination from its adjacent layers: the choroid and the photoreceptors. We compared the signature genes, gene expression profiles and functional annotations of the @entity19 and @entity1 @entity989 . RESULTS: We defined sets of @entity19 (64), @entity1 (171) and @entity19 - @entity1 interspecies (22) @entity989 signature genes. Not unexpectedly, our gene expression analysis and comparative functional annotation suggested that, in general, the @entity19 and @entity1 @entity989 are very similar. For example, we found similarities for general features, like "organ development" and "disorders related to neurological tissue". However, detailed analysis of the molecular pathways and networks associated with @entity989 functions, suggested also multiple species-specific differences, some of which may be relevant for the development of @entity1020 . For example, @entity8173 , most likely the main complement regulator in @entity1020 pathogenesis was highly expressed in @entity1 @entity989 , but almost absent in @entity19 @entity989 . Furthermore, functions assigned to @entity19 and @entity1 @entity989 expression profiles indicate (patho-) biological differences related to @entity1020 , such as oxidative stress, Bruch's membrane, immune-regulation and outer blood retina barrier. CONCLUSION: These differences may be important for the development of new therapeutic strategies and translational studies in age-related @entity1020 .

title: Comparison of @entity19 and @entity1 Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related XXXX .

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'RPE']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['age related macular degeneration', 'macular degeneration', 'AMD']

answer: @entity1020 :: (MESH:D008268,Disease) :: ['Macular Degeneration']


abstract: BACKGROUND: The @entity1 @entity989 ( @entity989 ) plays an important role in the pathogenesis of @entity1020 ( @entity1020 ). @entity1020 is the leading cause of @entity1939 worldwide. There is currently no effective treatment available. Preclinical studies in @entity1020 @entity19 models are essential to develop new therapeutics. This requires further in-depth knowledge of the similarities and differences between @entity19 and @entity1 @entity989 . METHODS: We performed a microarray study to identify and functionally annotate @entity989 specific gene expression in @entity19 and @entity1 @entity989 . We used a meticulous method to determine C57BL/6J @entity19 @entity989 signature genes, correcting for possible RNA contamination from its adjacent layers: the choroid and the photoreceptors. We compared the signature genes, gene expression profiles and functional annotations of the @entity19 and @entity1 @entity989 . RESULTS: We defined sets of @entity19 (64), @entity1 (171) and @entity19 - @entity1 interspecies (22) @entity989 signature genes. Not unexpectedly, our gene expression analysis and comparative functional annotation suggested that, in general, the @entity19 and @entity1 @entity989 are very similar. For example, we found similarities for general features, like "organ development" and "disorders related to neurological tissue". However, detailed analysis of the molecular pathways and networks associated with @entity989 functions, suggested also multiple species-specific differences, some of which may be relevant for the development of @entity1020 . For example, @entity8173 , most likely the main complement regulator in @entity1020 pathogenesis was highly expressed in @entity1 @entity989 , but almost absent in @entity19 @entity989 . Furthermore, functions assigned to @entity19 and @entity1 @entity989 expression profiles indicate (patho-) biological differences related to @entity1020 , such as oxidative stress, Bruch's membrane, immune-regulation and outer blood retina barrier. CONCLUSION: These differences may be important for the development of new therapeutic strategies and translational studies in age-related @entity1020 .

title: Comparison of XXXX and @entity1 Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related @entity1020 .

answer: @entity19 :: (10090,Species) :: ['Mouse']


abstract: BACKGROUND: The @entity1 @entity989 ( @entity989 ) plays an important role in the pathogenesis of @entity1020 ( @entity1020 ). @entity1020 is the leading cause of @entity1939 worldwide. There is currently no effective treatment available. Preclinical studies in @entity1020 @entity19 models are essential to develop new therapeutics. This requires further in-depth knowledge of the similarities and differences between @entity19 and @entity1 @entity989 . METHODS: We performed a microarray study to identify and functionally annotate @entity989 specific gene expression in @entity19 and @entity1 @entity989 . We used a meticulous method to determine C57BL/6J @entity19 @entity989 signature genes, correcting for possible RNA contamination from its adjacent layers: the choroid and the photoreceptors. We compared the signature genes, gene expression profiles and functional annotations of the @entity19 and @entity1 @entity989 . RESULTS: We defined sets of @entity19 (64), @entity1 (171) and @entity19 - @entity1 interspecies (22) @entity989 signature genes. Not unexpectedly, our gene expression analysis and comparative functional annotation suggested that, in general, the @entity19 and @entity1 @entity989 are very similar. For example, we found similarities for general features, like "organ development" and "disorders related to neurological tissue". However, detailed analysis of the molecular pathways and networks associated with @entity989 functions, suggested also multiple species-specific differences, some of which may be relevant for the development of @entity1020 . For example, @entity8173 , most likely the main complement regulator in @entity1020 pathogenesis was highly expressed in @entity1 @entity989 , but almost absent in @entity19 @entity989 . Furthermore, functions assigned to @entity19 and @entity1 @entity989 expression profiles indicate (patho-) biological differences related to @entity1020 , such as oxidative stress, Bruch's membrane, immune-regulation and outer blood retina barrier. CONCLUSION: These differences may be important for the development of new therapeutic strategies and translational studies in age-related @entity1020 .

title: Comparison of @entity19 and XXXX Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related @entity1020 .

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: UNASSIGNED: Despite major advances in understanding the molecular and genetic basis of @entity5 , @entity3 remains the cause of >90% of @entity5 -related mortality. Understanding @entity3 initiation and progression is critical to developing new therapeutic strategies to treat and prevent @entity3 . Prevailing theories hypothesize that @entity3 are seeded by rare @entity5 cells with unique properties, which may function like stem cells in their ability to initiate and propagate @entity5 . However, the identity of @entity3 -initiating cells in @entity1 @entity0 remains elusive, and whether @entity3 are hierarchically organized is unknown. Here we show at the single-cell level that early stage metastatic cells possess a distinct stem-like gene expression signature. To identify and isolate metastatic cells from @entity1 -derived xenograft models of @entity1 @entity0 , we developed a highly sensitive fluorescence-activated cell sorting (FACS)-based assay, which allowed us to enumerate metastatic cells in @entity19 peripheral tissues. We compared gene signatures in metastatic cells from tissues with low versus high metastatic burden. Metastatic cells from low-burden tissues were distinct owing to their increased expression of stem cell, epithelial-to-mesenchymal transition, pro-survival, and dormancy-associated genes. By contrast, metastatic cells from high-burden tissues were similar to primary @entity5 cells, which were more heterogeneous and expressed higher levels of luminal differentiation genes. Transplantation of stem-like metastatic cells from low-burden tissues showed that they have considerable @entity5 -initiating capacity, and can differentiate to produce luminal-like @entity5 cells. Progression to high metastatic burden was associated with increased proliferation and MYC expression, which could be attenuated by treatment with cyclin-dependent kinase (CDK) inhibitors. These findings support a hierarchical model for @entity3 , in which @entity3 are initiated by stem-like cells that proliferate and differentiate to produce advanced @entity3 .

title: Single-cell analysis reveals a stem-cell program in @entity1 metastatic XXXX cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['metastatic tumours', 'cancer', 'tumour']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases', 'metastatic disease']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: UNASSIGNED: Despite major advances in understanding the molecular and genetic basis of @entity5 , @entity3 remains the cause of >90% of @entity5 -related mortality. Understanding @entity3 initiation and progression is critical to developing new therapeutic strategies to treat and prevent @entity3 . Prevailing theories hypothesize that @entity3 are seeded by rare @entity5 cells with unique properties, which may function like stem cells in their ability to initiate and propagate @entity5 . However, the identity of @entity3 -initiating cells in @entity1 @entity0 remains elusive, and whether @entity3 are hierarchically organized is unknown. Here we show at the single-cell level that early stage metastatic cells possess a distinct stem-like gene expression signature. To identify and isolate metastatic cells from @entity1 -derived xenograft models of @entity1 @entity0 , we developed a highly sensitive fluorescence-activated cell sorting (FACS)-based assay, which allowed us to enumerate metastatic cells in @entity19 peripheral tissues. We compared gene signatures in metastatic cells from tissues with low versus high metastatic burden. Metastatic cells from low-burden tissues were distinct owing to their increased expression of stem cell, epithelial-to-mesenchymal transition, pro-survival, and dormancy-associated genes. By contrast, metastatic cells from high-burden tissues were similar to primary @entity5 cells, which were more heterogeneous and expressed higher levels of luminal differentiation genes. Transplantation of stem-like metastatic cells from low-burden tissues showed that they have considerable @entity5 -initiating capacity, and can differentiate to produce luminal-like @entity5 cells. Progression to high metastatic burden was associated with increased proliferation and MYC expression, which could be attenuated by treatment with cyclin-dependent kinase (CDK) inhibitors. These findings support a hierarchical model for @entity3 , in which @entity3 are initiated by stem-like cells that proliferate and differentiate to produce advanced @entity3 .

title: Single-cell analysis reveals a stem-cell program in XXXX metastatic @entity0 cells.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVES: To compare the efficacy of two exercise programmes in reducing @entity158 for individuals with non-specific @entity1643 and to examine the underlying mechanical factors related to @entity158 for individuals with NSLBP. DESIGN: A single-blind, randomized controlled trial. METHODS: Eighty @entity1 were recruited from eleven community-based general medical practices and randomized into two groups completing either a lumbopelvic motor control or a combined lumbopelvic motor control and progressive hip strengthening exercise therapy programme. All @entity1 received an education session, 6 rehabilitation sessions including real time ultrasound training, and a home based exercise programme manual and log book. The primary outcomes were @entity158 (0-100mm visual analogue scale), and disability (Oswestry Disability Index V2). The secondary outcomes were hip strength (N/kg) and two-dimensional frontal plane biomechanics (  ) measure during the static Trendelenburg test and while walking. All outcomes were measured at baseline and at 6-week follow up. RESULTS: There was no statistical difference in the change in @entity158 (x  =-4.0mm, t=-1.07, p=0.29, 95%CI -11.5, 3.5) or disability (x  =-0.3%, t=-0.19, p=0.85, 95%CI -3.5, 2.8) between groups. Within group comparisons revealed clinically meaningful reductions in @entity158 for both Group One (x  =-20.9mm, 95%CI -25.7, -16.1) and Group Two (x  =-24.9, 95%CI -30.8, -19.0). CONCLUSIONS: Both exercise programmes had similar efficacy in reducing @entity158 . The addition of hip strengthening exercises to a motor control exercise programme does not appear to result in improved clinical outcome for @entity158 for individuals with non-specific @entity1643 .

title: The effect of the addition of hip strengthening exercises to a lumbopelvic exercise programme for the treatment of non-specific XXXX : A randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain and disability', 'pain']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['low back pain']


abstract: AIMS: @entity2316 independently predicts @entity65 and @entity204 . We examined the @entity740 ( @entity740 , defined as an estimated GFR <  60  ml/min/1.73  m(2) ) and quality of care in a cross-sectional survey of adults (age >=   18  years) with @entity164  2 @entity6 across Asia. METHODS: The Joint Asia @entity6 Evaluation programme is a disease-management programme implemented using an electronic portal that systematically captures clinical characteristics of all @entity1 enrolled. Between July 2007 and December 2012, data on 28  110 consecutively enrolled @entity1 (China: 3415, Hong Kong: 15  196, India: 3714, Korea: 1651, Philippines: 3364, Vietnam: 692, Taiwan: 78) were analysed. RESULTS: In this survey, 15.9% of @entity1 had @entity740 , 25.0% had microalbuminuria and 12.5% had macroalbuminuria. @entity1 with @entity740 were less likely to achieve HbA1c   <  53  mmol/mol (7.0%) (36.0% vs. 42.3%) and blood pressure <  130/80  mmHg (20.8% vs. 35.3%), and were more likely to have @entity989 (26.2% vs. 8.7%), @entity16 (29.0% vs. 7.7%), @entity65 (26.6% vs. 8.7%) and self-reported hypoglycaemia (18.9% vs. 8.2%). Despite high frequencies of @entity633 (74.8%) and dyslipidaemia (93.0%) among @entity740 @entity1 , only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins. On logistic regression, old age, male gender, @entity286 use, long disease duration, high HbA1c , blood pressure and BMI, and low LDL @entity165 were independently associated with @entity740 (all P  <  0.05). CONCLUSIONS: The poor control of risk factors, suboptimal use of organ-protective drugs and high frequencies of hypoglycaemia highlight major treatment gaps in @entity1 with @entity2316 in Asia. This article is protected by copyright. All rights reserved.

title: Quality of care in @entity1 with @entity2316 in Asia: The Joint Asia XXXX Evaluation (JADE) Registry.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['Diabetic kidney disease', 'diabetic kidney disease']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['sensory neuropathy']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'burden of chronic kidney disease']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['premature death']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: AIMS: @entity2316 independently predicts @entity65 and @entity204 . We examined the @entity740 ( @entity740 , defined as an estimated GFR <  60  ml/min/1.73  m(2) ) and quality of care in a cross-sectional survey of adults (age >=   18  years) with @entity164  2 @entity6 across Asia. METHODS: The Joint Asia @entity6 Evaluation programme is a disease-management programme implemented using an electronic portal that systematically captures clinical characteristics of all @entity1 enrolled. Between July 2007 and December 2012, data on 28  110 consecutively enrolled @entity1 (China: 3415, Hong Kong: 15  196, India: 3714, Korea: 1651, Philippines: 3364, Vietnam: 692, Taiwan: 78) were analysed. RESULTS: In this survey, 15.9% of @entity1 had @entity740 , 25.0% had microalbuminuria and 12.5% had macroalbuminuria. @entity1 with @entity740 were less likely to achieve HbA1c   <  53  mmol/mol (7.0%) (36.0% vs. 42.3%) and blood pressure <  130/80  mmHg (20.8% vs. 35.3%), and were more likely to have @entity989 (26.2% vs. 8.7%), @entity16 (29.0% vs. 7.7%), @entity65 (26.6% vs. 8.7%) and self-reported hypoglycaemia (18.9% vs. 8.2%). Despite high frequencies of @entity633 (74.8%) and dyslipidaemia (93.0%) among @entity740 @entity1 , only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins. On logistic regression, old age, male gender, @entity286 use, long disease duration, high HbA1c , blood pressure and BMI, and low LDL @entity165 were independently associated with @entity740 (all P  <  0.05). CONCLUSIONS: The poor control of risk factors, suboptimal use of organ-protective drugs and high frequencies of hypoglycaemia highlight major treatment gaps in @entity1 with @entity2316 in Asia. This article is protected by copyright. All rights reserved.

title: Quality of care in @entity1 with XXXX in Asia: The Joint Asia @entity6 Evaluation (JADE) Registry.

answer: @entity2316 :: (MESH:D003928,Disease) :: ['diabetic kidney disease']


abstract: AIMS: @entity2316 independently predicts @entity65 and @entity204 . We examined the @entity740 ( @entity740 , defined as an estimated GFR <  60  ml/min/1.73  m(2) ) and quality of care in a cross-sectional survey of adults (age >=   18  years) with @entity164  2 @entity6 across Asia. METHODS: The Joint Asia @entity6 Evaluation programme is a disease-management programme implemented using an electronic portal that systematically captures clinical characteristics of all @entity1 enrolled. Between July 2007 and December 2012, data on 28  110 consecutively enrolled @entity1 (China: 3415, Hong Kong: 15  196, India: 3714, Korea: 1651, Philippines: 3364, Vietnam: 692, Taiwan: 78) were analysed. RESULTS: In this survey, 15.9% of @entity1 had @entity740 , 25.0% had microalbuminuria and 12.5% had macroalbuminuria. @entity1 with @entity740 were less likely to achieve HbA1c   <  53  mmol/mol (7.0%) (36.0% vs. 42.3%) and blood pressure <  130/80  mmHg (20.8% vs. 35.3%), and were more likely to have @entity989 (26.2% vs. 8.7%), @entity16 (29.0% vs. 7.7%), @entity65 (26.6% vs. 8.7%) and self-reported hypoglycaemia (18.9% vs. 8.2%). Despite high frequencies of @entity633 (74.8%) and dyslipidaemia (93.0%) among @entity740 @entity1 , only 49.0% were using renin-angiotensin system inhibitors and 53.6% were on statins. On logistic regression, old age, male gender, @entity286 use, long disease duration, high HbA1c , blood pressure and BMI, and low LDL @entity165 were independently associated with @entity740 (all P  <  0.05). CONCLUSIONS: The poor control of risk factors, suboptimal use of organ-protective drugs and high frequencies of hypoglycaemia highlight major treatment gaps in @entity1 with @entity2316 in Asia. This article is protected by copyright. All rights reserved.

title: Quality of care in XXXX with @entity2316 in Asia: The Joint Asia @entity6 Evaluation (JADE) Registry.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: The study meant to define the prognostic factors that help in prescribing intrauterine insemination (IUI) for @entity249 treatment which remains an area of continuous improvements. METHODS: The diagnostic indications of a cohort of IUI-treated @entity1 and their corresponding pregnancy rates (PRs) were randomly and prospectively studied among Saudi cohort of 303 @entity1 for a period of 20 months. The indications of IUI cases were statistically analyzed for those eligible @entity1 over a period of twenty months (January 2010 till August 2011), and the PR that corresponded to each group was investigated as well. P-value less than 0.05 was considered significant. RESULTS: The highest PR, 18.87%, of the @entity3610 ( @entity3610 )-only diagnosed @entity1 , was significantly higher than the average PR of all other indications combined, 7.22%, (p = 0.011, compared to all other groups combined). The second highest PR, 14.0%, of the @entity5274 ( @entity5274 )-only indication, was double the PR average of all other indications combined, though it did not reach significance. However, @entity3610 and @entity5274 accompanied by other indications caused the PR to drop to 5.88% and 5.56%, respectively. However, a group of some hormonal-imbalance based indications had the least PR (0.0% to 2.70%). Those indications were elevated serum FSH, @entity4089 , hypogonadotrophy, @entity1375 and @entity46 . The rest of the indications had an average PR (8.33% to 11.11%). CONCLUSION: There is a reasonable chance of conception after IUI treatment for female factor @entity249 except in cases with sever hormonal imbalance. The @entity3610 cases having the best success chances.

title: Accurate diagnosis as a prognostic factor in intrauterine insemination treatment of XXXX saudi @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4089 :: ('MESH:D006966', 'Disease') :: ['hyperprolactinemia']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovarian syndrome', 'PCOS']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism']

entities_list: @entity5274 :: ('MESH:D005184', 'Disease') :: ['TF', 'tubal factor']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

answer: @entity249 :: (MESH:D007246,Disease) :: ['infertile']


abstract: BACKGROUND: The study meant to define the prognostic factors that help in prescribing intrauterine insemination (IUI) for @entity249 treatment which remains an area of continuous improvements. METHODS: The diagnostic indications of a cohort of IUI-treated @entity1 and their corresponding pregnancy rates (PRs) were randomly and prospectively studied among Saudi cohort of 303 @entity1 for a period of 20 months. The indications of IUI cases were statistically analyzed for those eligible @entity1 over a period of twenty months (January 2010 till August 2011), and the PR that corresponded to each group was investigated as well. P-value less than 0.05 was considered significant. RESULTS: The highest PR, 18.87%, of the @entity3610 ( @entity3610 )-only diagnosed @entity1 , was significantly higher than the average PR of all other indications combined, 7.22%, (p = 0.011, compared to all other groups combined). The second highest PR, 14.0%, of the @entity5274 ( @entity5274 )-only indication, was double the PR average of all other indications combined, though it did not reach significance. However, @entity3610 and @entity5274 accompanied by other indications caused the PR to drop to 5.88% and 5.56%, respectively. However, a group of some hormonal-imbalance based indications had the least PR (0.0% to 2.70%). Those indications were elevated serum FSH, @entity4089 , hypogonadotrophy, @entity1375 and @entity46 . The rest of the indications had an average PR (8.33% to 11.11%). CONCLUSION: There is a reasonable chance of conception after IUI treatment for female factor @entity249 except in cases with sever hormonal imbalance. The @entity3610 cases having the best success chances.

title: Accurate diagnosis as a prognostic factor in intrauterine insemination treatment of @entity249 saudi XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Endothelial injuries regularly occur in @entity731 and during interventional therapies of the @entity432 . Disturbances in the endothelial integrity can lead to insufficient blood supply and bear the risk of @entity715 formation and acute @entity432 . At present, effective therapeutics to restore endothelial integrity are barely available. We analyzed the effect of pharmacological @entity33559 -inhibition by @entity12350 on endogenous progenitor cell-based endothelial regeneration via the SDF-1a/ @entity9843 -axis after acute endothelial damage in a @entity19 model of @entity130 . METHODS AND RESULTS: Induction of a defined endothelial injury was performed in the carotid artery of C57Bl/6 @entity19 which led to a local upregulation of SDF-1a expression. Animals were treated with placebo, @entity12350 or @entity12350 + @entity9019 . Using mass spectrometry we could prove that @entity12350 prevented cleavage of the chemokine SDF-1a. Accordingly, increased SDF-1a concentrations enhanced recruitment of systemically applied and endogenous circulating @entity9843 + progenitor cells to the site of @entity1317 followed by a significantly accelerated reendothelialization as compared to placebo-treated animals. Improved endothelial recovery, as well as recruitment of circulating @entity9843 + progenitor cells (CD133+, @entity11132 +), was reversed by @entity9843 -antagonization through @entity9019 . In addition, short-term @entity12350 treatment did not significantly promote @entity1373 . CONCLUSION: @entity12350 can accelerate endothelial regeneration after acute endothelial injury. @entity33559 inhibitors prevent degradation of the chemokine SDF-1a and thus improve the recruitment of regenerative circulating @entity9843 + progenitor cells which mediate local endothelial cell proliferation without adversely affecting vessel wall architecture.

title: Short-term inhibition of XXXX enhances endothelial regeneration after acute @entity1317 via enhanced recruitment of circulating progenitor cells.

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['neointimal or medial hyperplasia']

entities_list: @entity12350 :: ('MESH:C496398', 'Chemical') :: ['Sitagliptin']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusive disease', 'vascular occlusion']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['carotid injury']

answer: @entity33559 :: (13482(Tax:10090),Gene) :: ['DPP-4']


abstract: BACKGROUND: Endothelial injuries regularly occur in @entity731 and during interventional therapies of the @entity432 . Disturbances in the endothelial integrity can lead to insufficient blood supply and bear the risk of @entity715 formation and acute @entity432 . At present, effective therapeutics to restore endothelial integrity are barely available. We analyzed the effect of pharmacological @entity33559 -inhibition by @entity12350 on endogenous progenitor cell-based endothelial regeneration via the SDF-1a/ @entity9843 -axis after acute endothelial damage in a @entity19 model of @entity130 . METHODS AND RESULTS: Induction of a defined endothelial injury was performed in the carotid artery of C57Bl/6 @entity19 which led to a local upregulation of SDF-1a expression. Animals were treated with placebo, @entity12350 or @entity12350 + @entity9019 . Using mass spectrometry we could prove that @entity12350 prevented cleavage of the chemokine SDF-1a. Accordingly, increased SDF-1a concentrations enhanced recruitment of systemically applied and endogenous circulating @entity9843 + progenitor cells to the site of @entity1317 followed by a significantly accelerated reendothelialization as compared to placebo-treated animals. Improved endothelial recovery, as well as recruitment of circulating @entity9843 + progenitor cells (CD133+, @entity11132 +), was reversed by @entity9843 -antagonization through @entity9019 . In addition, short-term @entity12350 treatment did not significantly promote @entity1373 . CONCLUSION: @entity12350 can accelerate endothelial regeneration after acute endothelial injury. @entity33559 inhibitors prevent degradation of the chemokine SDF-1a and thus improve the recruitment of regenerative circulating @entity9843 + progenitor cells which mediate local endothelial cell proliferation without adversely affecting vessel wall architecture.

title: Short-term inhibition of @entity33559 enhances endothelial regeneration after acute XXXX via enhanced recruitment of circulating progenitor cells.

answer: @entity1317 :: (MESH:D057772,Disease) :: ['arterial injury']


abstract: BACKGROUND: @entity195 ( @entity195 ) is characterized by the accumulation of b-amyloid (Ab) associated with @entity1010 and @entity73 . The functional form to model the association between Ab and regional @entity1010 has not been well defined. To determine the relationship between Ab and @entity194 , we compared the performance of the usual dichotomization of cerebrospinal fluid (CSF) Ab to identify subjects as Ab+ and Ab- with a trilinear spline model of CSF Ab. METHODS: One hundred and eighty-three subjects with mild @entity73 and 108 cognitively normal controls with baseline CSF Ab and up to 4  years of longitudinal magnetic resonance imaging data from the @entity195 Neuroimaging Initiative were analyzed using mixed-effects regression. Piecewise-linear splines were used to evaluate the nonlinear nature of the association between CSF Ab and regional @entity194 and to identify points of acceleration of @entity194 with respect to Ab. Several parameterizations of CSF Ab were compared using likelihood ratio tests and the Akaike information criterion. Periods of acceleration of @entity194 in which subjects transition from CSF Ab negativity to CSF Ab positivity were estimated from the spline models and tested for significance. RESULTS: Spline models resulted in better fits for many temporal and parietal regions compared with the dichotomous models. The trilinear model showed that periods of acceleration of @entity194 varied greatly by region with early changes seen in the insula, amygdala, precuneus, hippocampus, and other temporal regions, occurring before the clinical threshold for CSF Ab positivity. CONCLUSION: The use of piecewise-linear splines provides an improved model of the nonlinear association between CSF Ab and regional @entity194 in regions implicated in the progression of @entity195 . The important biological finding of this work is that some brain regions show periods of accelerated volume loss well before the CSF Ab42 threshold. This implies that signs of @entity1010 develop before the current conventional definition of "preclinical @entity195 ".

title: The transitional association between b-amyloid pathology and regional XXXX .

entities_list: @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive decline']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", "Alzheimer's Disease"]

answer: @entity1010 :: (MESH:C566985,Disease) :: ['brain atrophy']


abstract: UNASSIGNED: BackgroundDespite the expanding worldwide distribution of @entity197 and its increasing relevance as arboviral vector, current methods to collect adult specimens are not optimal. Improved approaches are thus needed to monitor their density and pathogen infections, and to establish baseline data for control interventions. A widely used device is the BG-Sentinel (BG-trap) which mostly targets host-seeking females attracted by release of @entity515 and/or a synthetic odour blend (the BG lure). We compared the attractiveness of this blend to that of the Mbita ( @entity36727 ) lure, a new synthetic blend of proven efficiency in attracting @entity311 vectors, and evaluated the additional effect of @entity515 to the two odour baits.FindingsWe carried out 6x6 Latin square experiments in two Ae. @entity277 areas in Rome, baiting the BG-traps as follows: @entity515 , BG lure, @entity36727 lure, BG lure  +  @entity515 , @entity36727 lure  +  @entity515 , no bait. @entity515 was derived from @entity375 -fermented sugar. Overall, 949 females and 816 males were collected. Baited traps collected significantly more females than unbaited ones. Traps baited with either lures in combination with @entity515 were more effective than those baited with @entity515 alone. No significant differences were observed in female captures between traps baited with any of the two lures, nor between the two lures, independently from the addition of @entity515 . The use of BG lure  +  @entity515 significantly increased males catches compared to unbaited traps.ConclusionsThe results suggest a broad significance of the @entity36727 lure for sampling medically important mosquito species and highlight the high efficacy of the combination of lures  +  @entity515 for female Ae. albopictus and of BG lure  +  @entity515 for males, leading to consider @entity515 as an essential additional cue for the sampling of this species.

title: Field evaluation of a novel synthetic odour blend and of the synergistic role of carbon dioxide for sampling host-seeking XXXX adults in Rome, Italy.

entities_list: @entity277 :: ('MESH:D013984', 'Disease') :: ['albopictus-infested']

entities_list: @entity197 :: ('7160', 'Species') :: ['Aedes albopictus']

entities_list: @entity311 :: ('MESH:D008288', 'Disease') :: ['Afrotropical malaria']

answer: @entity197 :: (7160,Species) :: ['Aedes albopictus']


abstract: OBJECTIVE: To assess if a 12-week exercise intervention to improve aerobic fitness, muscle strength, and core stability also had an impact on @entity1295 , @entity158 , activity, and participation in adults with @entity13785 , an @entity74 . DESIGN: Open-label trial. Change was assessed by the chi-square test and Wilcoxon signed-rank test. SETTING: Physiotherapy practices. @entity1 : Mildly affected adult @entity1 with @entity13785 who were not dependent on ventilators and/or walking devices and were receiving enzyme replacement therapy. INTERVENTION: @entity1 participated in a 12-week exercise program, which included 36 sessions of standardized aerobic, resistance, and core stability exercises. MAIN OUTCOME MEASURES: Before and after the training program we evaluated @entity1295 (Fatigue Severity Scale), @entity158 (yes/no), motor function (Quantitative Muscle Function Test, Rasch-built Pompe-specific Activity Scale), amount of physical activity (activity monitor), and health status (Medical Outcomes Study 36-Item Short-Form Health Survey). RESULTS: Of the 25 @entity1 enrolled, 23 completed the program. At the end of the program, levels of @entity1295 (median, 5.33 to 4.78, P=.01) and @entity158 (56.5% to 21.7%, P=.04) improved. The quality of motor function and the amount of physical activity @entity1 engaged in did not change. Changes in @entity158 and @entity1295 were not related to improvements in aerobic fitness or muscle strength. CONCLUSIONS: This study in mildly affected adult @entity1 with @entity13785 suggests that a combined training program aiming to increase aerobic fitness, muscle strength, and core stability also leads to improvements in @entity1295 and @entity158 .

title: Exercise training in adults with @entity13785 : the effects on @entity158 , XXXX , and functioning.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS']

entities_list: @entity13785 :: ('MESH:D006009', 'Disease') :: ['Pompe disease']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited neuromuscular disorder']

answer: @entity1295 :: (MESH:D005221,Disease) :: ['fatigue']


abstract: OBJECTIVE: To assess if a 12-week exercise intervention to improve aerobic fitness, muscle strength, and core stability also had an impact on @entity1295 , @entity158 , activity, and participation in adults with @entity13785 , an @entity74 . DESIGN: Open-label trial. Change was assessed by the chi-square test and Wilcoxon signed-rank test. SETTING: Physiotherapy practices. @entity1 : Mildly affected adult @entity1 with @entity13785 who were not dependent on ventilators and/or walking devices and were receiving enzyme replacement therapy. INTERVENTION: @entity1 participated in a 12-week exercise program, which included 36 sessions of standardized aerobic, resistance, and core stability exercises. MAIN OUTCOME MEASURES: Before and after the training program we evaluated @entity1295 (Fatigue Severity Scale), @entity158 (yes/no), motor function (Quantitative Muscle Function Test, Rasch-built Pompe-specific Activity Scale), amount of physical activity (activity monitor), and health status (Medical Outcomes Study 36-Item Short-Form Health Survey). RESULTS: Of the 25 @entity1 enrolled, 23 completed the program. At the end of the program, levels of @entity1295 (median, 5.33 to 4.78, P=.01) and @entity158 (56.5% to 21.7%, P=.04) improved. The quality of motor function and the amount of physical activity @entity1 engaged in did not change. Changes in @entity158 and @entity1295 were not related to improvements in aerobic fitness or muscle strength. CONCLUSIONS: This study in mildly affected adult @entity1 with @entity13785 suggests that a combined training program aiming to increase aerobic fitness, muscle strength, and core stability also leads to improvements in @entity1295 and @entity158 .

title: Exercise training in adults with @entity13785 : the effects on XXXX , @entity1295 , and functioning.

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: OBJECTIVE: To assess if a 12-week exercise intervention to improve aerobic fitness, muscle strength, and core stability also had an impact on @entity1295 , @entity158 , activity, and participation in adults with @entity13785 , an @entity74 . DESIGN: Open-label trial. Change was assessed by the chi-square test and Wilcoxon signed-rank test. SETTING: Physiotherapy practices. @entity1 : Mildly affected adult @entity1 with @entity13785 who were not dependent on ventilators and/or walking devices and were receiving enzyme replacement therapy. INTERVENTION: @entity1 participated in a 12-week exercise program, which included 36 sessions of standardized aerobic, resistance, and core stability exercises. MAIN OUTCOME MEASURES: Before and after the training program we evaluated @entity1295 (Fatigue Severity Scale), @entity158 (yes/no), motor function (Quantitative Muscle Function Test, Rasch-built Pompe-specific Activity Scale), amount of physical activity (activity monitor), and health status (Medical Outcomes Study 36-Item Short-Form Health Survey). RESULTS: Of the 25 @entity1 enrolled, 23 completed the program. At the end of the program, levels of @entity1295 (median, 5.33 to 4.78, P=.01) and @entity158 (56.5% to 21.7%, P=.04) improved. The quality of motor function and the amount of physical activity @entity1 engaged in did not change. Changes in @entity158 and @entity1295 were not related to improvements in aerobic fitness or muscle strength. CONCLUSIONS: This study in mildly affected adult @entity1 with @entity13785 suggests that a combined training program aiming to increase aerobic fitness, muscle strength, and core stability also leads to improvements in @entity1295 and @entity158 .

title: Exercise training in adults with XXXX : the effects on @entity158 , @entity1295 , and functioning.

answer: @entity13785 :: (MESH:D006009,Disease) :: ['Pompe disease']


abstract: BACKGROUND: @entity55 is a major, complicated disease in @entity1 with @entity303 . However, the influence of @entity55 on the prognosis of @entity1 with varying types of @entity303 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity1 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity1 with subtypes of @entity303 , specifically @entity195 ( @entity195 ), @entity1832 ( @entity1832 ), or @entity1294 ( @entity1294 ), were neuropathologically diagnosed and examined. @entity55 incidence, cause of @entity204 , and the clinical time-course of @entity303 were compared among the @entity303 subtypes. The time to @entity204 from @entity303 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity303 with or without @entity55 . Risk factors for survival time on all study @entity1 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity1 , 63 (40.1%) had @entity195 , 42 (26.8%) had @entity1832 , and 52 (33.1%) had @entity1294 . @entity55 complication was observed with high incidence in each subtype of @entity303 , especially in @entity1832 (90.5%). The median total duration from @entity303 onset to @entity204 was 8 years in @entity195 and @entity1832 , and 5 years in @entity1294 . The @entity1294 subtype had more male @entity1 than @entity195 or @entity1832 (P = 0.010), and age of @entity204 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity55 (P = 0.002). The factors associated with shorter survival time were male gender, @entity55 , @entity6 , age of @entity303 onset   >=    75   years, and @entity1294 . CONCLUSIONS: @entity55 complications shortened the survival time of @entity1 with @entity195 , @entity1832 , and @entity1294 .

title: Influence of @entity55 on the prognosis of @entity1 with autopsy-confirmed XXXX , @entity1832 , and @entity1294 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia complications', 'pneumonia', 'Pneumonia']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity1294 :: ('MESH:D015140', 'Disease') :: ['vascular dementia', 'VaD']

entities_list: @entity1832 :: ('MESH:D020961', 'Disease') :: ['dementia with Lewy bodies', 'DLB']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']


abstract: BACKGROUND: @entity55 is a major, complicated disease in @entity1 with @entity303 . However, the influence of @entity55 on the prognosis of @entity1 with varying types of @entity303 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity1 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity1 with subtypes of @entity303 , specifically @entity195 ( @entity195 ), @entity1832 ( @entity1832 ), or @entity1294 ( @entity1294 ), were neuropathologically diagnosed and examined. @entity55 incidence, cause of @entity204 , and the clinical time-course of @entity303 were compared among the @entity303 subtypes. The time to @entity204 from @entity303 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity303 with or without @entity55 . Risk factors for survival time on all study @entity1 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity1 , 63 (40.1%) had @entity195 , 42 (26.8%) had @entity1832 , and 52 (33.1%) had @entity1294 . @entity55 complication was observed with high incidence in each subtype of @entity303 , especially in @entity1832 (90.5%). The median total duration from @entity303 onset to @entity204 was 8 years in @entity195 and @entity1832 , and 5 years in @entity1294 . The @entity1294 subtype had more male @entity1 than @entity195 or @entity1832 (P = 0.010), and age of @entity204 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity55 (P = 0.002). The factors associated with shorter survival time were male gender, @entity55 , @entity6 , age of @entity303 onset   >=    75   years, and @entity1294 . CONCLUSIONS: @entity55 complications shortened the survival time of @entity1 with @entity195 , @entity1832 , and @entity1294 .

title: Influence of @entity55 on the prognosis of @entity1 with autopsy-confirmed @entity195 , @entity1832 , and XXXX .

answer: @entity1294 :: (MESH:D015140,Disease) :: ['vascular dementia']


abstract: BACKGROUND: @entity55 is a major, complicated disease in @entity1 with @entity303 . However, the influence of @entity55 on the prognosis of @entity1 with varying types of @entity303 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity1 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity1 with subtypes of @entity303 , specifically @entity195 ( @entity195 ), @entity1832 ( @entity1832 ), or @entity1294 ( @entity1294 ), were neuropathologically diagnosed and examined. @entity55 incidence, cause of @entity204 , and the clinical time-course of @entity303 were compared among the @entity303 subtypes. The time to @entity204 from @entity303 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity303 with or without @entity55 . Risk factors for survival time on all study @entity1 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity1 , 63 (40.1%) had @entity195 , 42 (26.8%) had @entity1832 , and 52 (33.1%) had @entity1294 . @entity55 complication was observed with high incidence in each subtype of @entity303 , especially in @entity1832 (90.5%). The median total duration from @entity303 onset to @entity204 was 8 years in @entity195 and @entity1832 , and 5 years in @entity1294 . The @entity1294 subtype had more male @entity1 than @entity195 or @entity1832 (P = 0.010), and age of @entity204 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity55 (P = 0.002). The factors associated with shorter survival time were male gender, @entity55 , @entity6 , age of @entity303 onset   >=    75   years, and @entity1294 . CONCLUSIONS: @entity55 complications shortened the survival time of @entity1 with @entity195 , @entity1832 , and @entity1294 .

title: Influence of XXXX on the prognosis of @entity1 with autopsy-confirmed @entity195 , @entity1832 , and @entity1294 .

answer: @entity55 :: (MESH:D011014,Disease) :: ['pneumonia complications']


abstract: BACKGROUND: @entity55 is a major, complicated disease in @entity1 with @entity303 . However, the influence of @entity55 on the prognosis of @entity1 with varying types of @entity303 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity1 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity1 with subtypes of @entity303 , specifically @entity195 ( @entity195 ), @entity1832 ( @entity1832 ), or @entity1294 ( @entity1294 ), were neuropathologically diagnosed and examined. @entity55 incidence, cause of @entity204 , and the clinical time-course of @entity303 were compared among the @entity303 subtypes. The time to @entity204 from @entity303 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity303 with or without @entity55 . Risk factors for survival time on all study @entity1 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity1 , 63 (40.1%) had @entity195 , 42 (26.8%) had @entity1832 , and 52 (33.1%) had @entity1294 . @entity55 complication was observed with high incidence in each subtype of @entity303 , especially in @entity1832 (90.5%). The median total duration from @entity303 onset to @entity204 was 8 years in @entity195 and @entity1832 , and 5 years in @entity1294 . The @entity1294 subtype had more male @entity1 than @entity195 or @entity1832 (P = 0.010), and age of @entity204 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity55 (P = 0.002). The factors associated with shorter survival time were male gender, @entity55 , @entity6 , age of @entity303 onset   >=    75   years, and @entity1294 . CONCLUSIONS: @entity55 complications shortened the survival time of @entity1 with @entity195 , @entity1832 , and @entity1294 .

title: Influence of @entity55 on the prognosis of @entity1 with autopsy-confirmed @entity195 , XXXX , and @entity1294 .

answer: @entity1832 :: (MESH:D020961,Disease) :: ['dementia with Lewy bodies']


abstract: BACKGROUND: @entity55 is a major, complicated disease in @entity1 with @entity303 . However, the influence of @entity55 on the prognosis of @entity1 with varying types of @entity303 has not been fully evaluated. METHODS: We retrospectively analyzed the data from medical and autopsy reports. All study @entity1 had been hospitalized and underwent brain autopsy in a hospital in Toyohashi, Japan, between 2005 and 2014. The @entity1 with subtypes of @entity303 , specifically @entity195 ( @entity195 ), @entity1832 ( @entity1832 ), or @entity1294 ( @entity1294 ), were neuropathologically diagnosed and examined. @entity55 incidence, cause of @entity204 , and the clinical time-course of @entity303 were compared among the @entity303 subtypes. The time to @entity204 from @entity303 onset (survival time) was compared by the Kaplan-Meier method among subtypes of @entity303 with or without @entity55 . Risk factors for survival time on all study @entity1 were analyzed with the Cox proportional hazard model. RESULTS: Of the 157 eligible @entity1 , 63 (40.1%) had @entity195 , 42 (26.8%) had @entity1832 , and 52 (33.1%) had @entity1294 . @entity55 complication was observed with high incidence in each subtype of @entity303 , especially in @entity1832 (90.5%). The median total duration from @entity303 onset to @entity204 was 8 years in @entity195 and @entity1832 , and 5 years in @entity1294 . The @entity1294 subtype had more male @entity1 than @entity195 or @entity1832 (P = 0.010), and age of @entity204 in this group was the youngest among the three groups (P = 0.018). A significant difference was observed in the survival time by the Kaplan-Meier method among the three groups (P < 0.001) and among the groups with @entity55 (P = 0.002). The factors associated with shorter survival time were male gender, @entity55 , @entity6 , age of @entity303 onset   >=    75   years, and @entity1294 . CONCLUSIONS: @entity55 complications shortened the survival time of @entity1 with @entity195 , @entity1832 , and @entity1294 .

title: Influence of @entity55 on the prognosis of XXXX with autopsy-confirmed @entity195 , @entity1832 , and @entity1294 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND AND OBJECTIVES: It is crucial to decrease @entity548 during functional endoscopic sinus surgery. Our primary goal was to investigate the effects of magnesium sulfate and dexmedetomidine used for controlled @entity551 on the visibility of the surgical site. METHODS: 60 @entity1 aged between 18 and 65 years were enrolled. In the magnesium sulfate group (Group M), @entity1 were administered 40mg/kg magnesium sulfate in 100mL saline solution over 10min as the intravenous loading dose 10min before induction, with a subsequent 10-15 g/kg/h infusion during surgery. In the dexmedetomidine group (Group D), @entity1 were administered 1 g/kg dexmedetomidine in 100mL saline solution as the loading dose 10min before surgery and 0.5-1 g/kg/h dexmedetomidine during surgery. Deliberate @entity551 was defined as a mean arterial pressure of 60-70mmHg. RESULTS: Bleeding score was significantly decreased in Group D (p=0.002). Mean arterial pressure values were significantly decreased in Group D compared to that in Group M, except for the initial stage, after induction and 5min after intubation (p<0.05). The number of @entity1 who required nitroglycerine was significantly lower in Group D (p=0.01) and surgeon satisfaction was significantly increased in the same group (p=0.001). Aldrete recovery score >= 9 duration was significantly shorter in Group D (p=0.001). There was no difference between the two groups in terms of recovery room verbal numerical rating scale. CONCLUSIONS: Dexmedetomidine can provide more effective controlled @entity551 and thus contribute to improved visibility of the surgical site.

title: Comparison between magnesium sulfate and dexmedetomidine in controlled XXXX during functional endoscopic sinus surgery.

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity551 :: (MESH:D007022,Disease) :: ['hypotension']


abstract: Airborne particulate matter was collected on filters at various times in Duisburg, Duesseldorf, Muenster and in 2 rural areas. After extraction with organic solvents the extract was partly fractionated and analyzed for @entity3015 and 7 other @entity2555 ( @entity2556 ). The carcinogenicity was examined with the subcutaneous test using 7000 @entity19 in total. The amount of extract required was relatively small. Extracts from suspended matter with a @entity3015 content of 0.37 to 1.1 microgram @entity3015 brought about @entity5 rates in the range of 30%. On account of the results the following can be concluded: 1. The total extract of atmospheric particulates results in definite dose-response relationship, when the part of the compounds not belonging to the @entity2556 is rather low. 2. The @entity2556 fractions derived from the suspended matter collected in different cities show the same carcinogenic potency, when they are adjusted to the same @entity3015 level by means of concentration or dilution. 3. The @entity2556 bear the most important share with respect to the carcinogenic potency of an extract from suspended matter. 4. Numerous compounds (polar substances) which are not classed with the @entity2556 are carcinogenic to some extent, partly they are able to inhibit the carcinogenic effect. 5. The dose-response relationship of @entity3015 is strongly leveled off in general when all the substances of an extract are present. That means when the dose of an extract is low, the importance of @entity3015 becomes less. Therefore a fixed ratio concerning the effect of @entity3015 within an extract cannot be given. It has to be examined in particular, which @entity2556 and non- @entity2556 are necessary to analyse in order to describe the carcinogenic effect due to an extract from airborne particulates. Much more attention is to be payed to the polar substances.

title: [Studies on the tumourigenicity of extracts and their fractions of airborne particulates with the subcutaneous test in the XXXX (author's transl)].

entities_list: @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: Polygraphy (PG) and polysomnography (PSG) are used in clinical settings in Europe for diagnosing @entity27 ( @entity27 ), but their equivalence in unselected clinical cohorts is unknown. We hypothesized that the method would affect both diagnostic outcomes and disease severity stratification. Data from 11  049 @entity1 in the multi-centre European Sleep Apnea Cohort (ESADA) with suspected @entity27 (male and female, aged 18-80  years) were used in two groups of @entity1 to compare PG (n  =  5745) and PSG (n  =  5304). Respiratory events were scored using the 2007 American Association of Sleep Medicine (AASM) criteria. In subjects who underwent PSG, mean @entity27 index (AHI) using sleep time (AHIPSG 31.0      26.1  h(-1) ) and total analysed time (TAT) (AHITAT 24.7      22.0  h(-1) ) were higher than in subjects who underwent PG (AHIPG 22.0      23.5  h(-1) ) (P  <  0.0001). The @entity26 desaturation index (ODI) was lower in subjects investigated with PG (ODIPG 18.4      21.7  h(-1) ) compared to subjects investigated with PSG (ODIPSG 23.0      25.3  h(-1) ) but not different when the PSG was indexed by TAT (ODITAT 18.6      21.4  h(-1) , P  <  0.65). The proportion of @entity1 with an AHI >=   15 was 64% in the subjects who underwent PSG and 47% in the subjects who underwent PG (P  <  0.001). Overall, @entity1 investigated using PG are likely to have a 30% lower AHI on average, compared to @entity1 investigated by PSG. This study suggests that PG interpreted using standard guidelines results in underdiagnosis and misclassification of @entity27 . We advocate the development of PG-specific guidelines for the management of @entity27 @entity1 .

title: The diagnostic method has a strong influence on classification of XXXX .

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['apnea-hypopnea', 'obstructive sleep apnea', 'OSA']

answer: @entity27 :: (MESH:D020181,Disease) :: ['obstructive sleep apnea']


abstract: AIMS: @entity740 ( @entity740 ) progression is accompanied by systemic oxidative stress, which contributes to an increase in the risk of @entity65 ( @entity65 ). @entity898 (NAC) is among the most studied antioxidants, but its therapeutic benefits in @entity740 -associated CVD remain controversial. Here, we investigated whether NAC could inhibit the oxidative stress induced by @entity5507 in vitro and in vivo. MAIN METHODS: Endothelial and smooth muscle cells were challenged with @entity1 uremic or non-uremic sera, and the effects of a pre-treatment with 2mM NAC were evaluated. Reactive @entity26 species (ROS) production, protein oxidation and total @entity2041 / @entity9492 (tGSH/ @entity9492 ) ratios were measured. Five-sixths nephrectomized or sham-operated @entity35 were orally treated (in the drinking water) with 60mg/kg/day NAC or not treated for 53days. Plasma @entity462 / @entity1434 reduction potential Eh(Cyss/2Cys) was determined as a novel marker of the systemic oxidative stress. KEY FINDINGS: NAC inhibited all the determined oxidative stress parameters, likely by increasing the t @entity2197 / @entity9492 ratio, in both cell lines exposed to uremic serum. Orally administered NAC attenuated the systemic oxidative stress in uremic @entity35 . SIGNIFICANCE: The present results indicate that NAC, by preventing @entity2197 depletion in vascular cells exposed to uremic serum and by attenuating the systemic oxidative stress during @entity740 progression, emerges as a potential strategy to prevent the oxidative stress induced by @entity137 in the vascular system.

title: XXXX as a potential strategy to attenuate the oxidative stress induced by uremic serum in the vascular system.

entities_list: @entity9492 :: ('MESH:D019803', 'Chemical') :: ['GSSG', 'glutathione disulfide']

entities_list: @entity462 :: ('MESH:D003545', 'Chemical') :: ['cysteine']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['uremic toxicity']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity898 :: ('MESH:D000111', 'Chemical') :: ['N-acetylcysteine']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['Chronic kidney disease', 'CKD']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVDs', 'cardiovascular diseases']

answer: @entity898 :: (MESH:D000111,Chemical) :: ['N-acetylcysteine']


abstract: BACKGROUND: Previous radiation for @entity263 ( @entity263 ) contra-indicates neoadjuvant chemoradiotherapy for @entity5 ( @entity5 ) because of risk of cumulative radiation dose @entity137 . Postoperative outcomes after proctectomy have not been well studied in these @entity1 who did not receive optimal treatment. METHODS: Eighty-four consecutive male @entity1 underwent surgery for stage II-III mid or low @entity5 between 2002 and 2011. @entity1 who previously received radiation for @entity263 (n   =   8) and @entity1 who had not previously undergone radiation for @entity263 but who received neoadjuvant chemoradiotherapy for @entity5 (n   =   64) were retrospectively compared. RESULTS: Previous radiation for @entity263 was an independent factor that significantly increased intraoperative (25% vs. 1.6%, P   =   0.002) and postoperative morbidities (62.5% vs. 28.1%, P   =   0.028), @entity834 (62.5% vs. 12.5%, P   <   0.001) and definitive stoma rates (25% vs. 17.4%, P   =   0.022). It significantly altered median overall survival (32.0 vs. 130.6 months, P   =   0.05) and local recurrence-free survival rates (14.0 months vs. "median not reached," P   =   0.016). CONCLUSIONS: This is the first report of altered survival rates after proctectomy in @entity1 who had previously received radiation for @entity263 . Postoperative morbidity and definitive defunctioning stoma rates were significantly increased in these @entity1 with poor prognoses. Therapeutic strategies should thus be individualized. Large, multicenter cohort studies are needed. J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Previous radiation for prostate XXXX alters surgical and oncologic outcomes after @entity5 surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leakage']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'PC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['RC', 'rectal cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['neoplasm']