abstract: OBJECTIVE: To evaluate the clinical outcome of the femtosecond laser-assisted @entity231 surgery (FLACS) in our first 300 cases. METHODS: In this retrospective study, the study group comprised 300 cases (300 eyes) in which FLACS was done. The control group comprised 300 cases (300 eyes) in which phacoemulsification was performed. The steps of the FLACS included capsulotomy, @entity1949 , @entity2687 , and creation of incisions within the peripheral cornea to aid the correction of pre-existing @entity940 . After the FLACS, 2.2-mm coaxial micro-incision phacoemulsification and implantation of an intraocular lens were operated. The preoperative best corrected visual acuity (BCVA) and postoperative uncorrected visual acuity (UCVA), the cumulative dissipated energy (CDE) of the phacoemulsification, and the parameters of the FLACS, including the docking time, the suction time and the laser time, were recorded. The complications of the FLACS were analyzed. RESULTS: The FLACS was successfully completed in 99.33% of the cases. The docking time was (24.6    16.8) sec, the suction time was (101.27    20.09) sec, and the laser time was (23.3    5.5) sec. The most common complications of the FLACS included suction break (7/300, 2.33%), @entity548 (58/300, 19.33%), pupillary constriction (47/300, 15.67%), incision at a wrong site (13/300, 4.33%), anterior capsular tag (17/300, 5.67%), decentration of the capsulorhexis (11/300, 3.67%), failure to split the lens nucleus (5/300, 1.67%), and posterior capsular @entity397 (1/300, 0.33%). The CDE was 5.52    5.18 in the FLACS group and 8.37    7.91 in the traditional phaco group (P < 0.05). The UCVA was 0.12    0.08 and 0.13    0.11 at 1 month after the FLACS and traditional phaco, respectively (P > 0.05). CONCLUSIONS: Compared with the conventional phacoemulsification surgery, the FLACS can achieve less CDE and better early postoperative visual acuity. Long-term effects remain to be investigated.

title: [Preliminary evaluation of the femtosecond laser-assisted XXXX surgery in 300 cases].

entities_list: @entity940 :: ('MESH:D001251', 'Disease') :: ['astigmatism']

entities_list: @entity1949 :: ('MESH:D012892', 'Disease') :: ['lens fragmentation']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['subconjunctival hemorrhage']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptures']

entities_list: @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal incisions']

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']


abstract: PURPOSE: @entity5 boards (MDTs) are conducted worldwide for the management of @entity1 with @entity5 , and they deliver a higher standard of care by simultaneously involving different specialists in diagnosis and treatment planning. However, information of paediatric MDTs functioning is scarce. A pilot study was conducted in Spain in the frame of the European Expert Paediatric Oncology Reference Network for Diagnostics and Treatment (ExPO-r-Net). METHODS: A specific questionnaire was designed regarding various features of MDT practice. Data collected included information on the centres and the team, infrastructure for meetings, MDT organization/logistics and clinical decision-making. The survey was distributed to all Paediatric Oncology Units that register @entity1 in the Spanish Registry of Childhood Tumours (RETI-SEHOP). RESULTS: 32 out of 43 contacted centres responded the questionnaire (74  % response rate; 88  % response rate for centres with >25 new @entity1 /year). All units with >25 new @entity1 /year have a dedicated Paediatric MDT compared to 76  % of units with  <=25 new @entity1 /year. MDTs should be improved at institutional level by clear protected time in service planning for all specialists involved, incentives for attendance and attendance registration. Clinical decision-making process and follow-up of recommendation adherence should be assessed and potential legal responsibilities for physicians participating in @entity5 Board defined. Network collaboration through virtual MDTs, using available videoconferencing tools, is an opportunity to share expertise among centres.

title: XXXX boards in Spain: a national survey.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Multidisciplinary tumour', 'Tumour']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Paediatric tumour']


abstract: 43 kidney recipients were followed up for 12 months after renal transplantation. In 13 @entity1 treated with @entity205 for 6 months polyglobulia was found, which subsided after conversion of immunosuppressive therapy. A highly significant correlation was found between the presence of the antigen A3 and the polyglobulia in kidney recipients treated by @entity205 . The serum ferritin level was not elevated in kidney recipients who were carriers of the " @entity9595 alleles". Results obtained in this study seem to justify the following conclusions: 1. Kidney recipients who are carriers of " @entity9595 alleles" show a threefold higher risk of posttransplant polyglobulia. 2. Presence of " @entity9595 alleles" is not an absolute predictor of polyglobulia in @entity1 after kidney transplantation. 3. Both etiology and pathogenesis of posttransplant polyglobulia do not seem to be homogeneous. @entity205 , in contrast to @entity500 , seems to have a promoting effect on the development of posttransplant polyglobulia. Therefore treatment of kidney transplant @entity1 with @entity205 , who are carriers of " @entity9595 alleles", needs careful monitoring.

title: [The role of " XXXX alleles" in the pathogenesis of polyglobulia after renal transplantation].

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporin A', 'Cyclosporin A']

entities_list: @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine']

entities_list: @entity9595 :: ('MESH:D006432', 'Disease') :: ['hemochromatosis']

answer: @entity9595 :: (MESH:D006432,Disease) :: ['hemochromatosis']


abstract: OBJECTIVE: To investigate the injury effect of high frequency electrocoagulation ( @entity14398 ) by ultrafine-needle on the cutaneous @entity8702 by histopathologic study of cock comb. METHODS: 32 male cocks were randomly divided into 4 groups with 8 animals in each group. 3 experimental groups received @entity14398 with different power (6W, 8W, 10W) on the cock comb. Specimens were taken from cock combs for histologic study immediately after treatment and 7, 14, 21, 28 days later. RESULTS: After treatment, the cock combs turned pale and followed with @entity2318 formation. The shape of combs changed a lot after high power treatment. Immediately after treatment, the capillary number in the experimental groups decreased markedly under light microscope, compared with that in control group (P < 0.05). After that, the capillary number in experimental group increased. 7 days after treatment, the capillary number in experimental groups was still significantly lower than that in control groups (P < 0.01), but not markedly different between the three experiment groups (P > 0.05). Collagen formation also increased after treatment (P < 0.05), which was higher in experimental groups with high power (P < 0.05, correlation coefficient r > 0.5). CONCLUSIONS: @entity14398 with ultrafine needle can effectively decrease the capillary number in cock comb. The 6W treatment is mini-invasive and will not destroy the comb shape with good cosmetic results. The technique may be used for the treatment of cutaneous @entity8702 .

title: [Effect of high frequency electrocoagulation by ultrafine-needle on the cutaneous XXXX : a preliminary study on cock combs].

entities_list: @entity8702 :: ('MESH:D018324', 'Disease') :: ['capillary hemangiomas', 'capillary hemangioma']

answer: @entity8702 :: (MESH:D018324,Disease) :: ['capillary hemangiomas']


abstract: UNASSIGNED: @entity4008 is a disease with a high morbidity and mortality. It may be caused by the zoonotic pathogen @entity55752 , which is part of the commensal oral flora in @entity235 and @entity468 . We report three cases of @entity55752 @entity693 in a nationwide cohort study of @entity4008 @entity1 and performed a review of the literature. Three episodes of @entity55752 @entity693 were identified in three @entity1 included in a nationwide cohort study from 2006 through 2014. The calculated annual incidence was 0.03 per million adults. When combined with the literature, 33 @entity1 were identified of which 28 were male (85%). The median age was 63  years, and 13 (42%) were immunocompromised, which consisted of alcoholism in 7 (21%). Animal contact could be established in 29 of 30 @entity1 (93%) and consisted of @entity235 bites in 22 of 29 (76%). One @entity1 died (3%) and 8 had neurological sequelae upon discharge (25%), most often @entity393 (n  =  6, 19%). @entity55752 @entity693 is associated with @entity235 bites. Although mortality is relatively low, survivors often have neurological sequelae.

title: XXXX @entity693 : Three Cases and a Review of the Literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4008 :: ('MESH:D016920', 'Disease') :: ['bacterial meningitis', 'Bacterial meningitis']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity55752 :: ('28188', 'Species') :: ['C. canimorsus', 'Capnocytophaga canimorsus']

answer: @entity55752 :: (28188,Species) :: ['Capnocytophaga canimorsus']


abstract: UNASSIGNED: @entity4008 is a disease with a high morbidity and mortality. It may be caused by the zoonotic pathogen @entity55752 , which is part of the commensal oral flora in @entity235 and @entity468 . We report three cases of @entity55752 @entity693 in a nationwide cohort study of @entity4008 @entity1 and performed a review of the literature. Three episodes of @entity55752 @entity693 were identified in three @entity1 included in a nationwide cohort study from 2006 through 2014. The calculated annual incidence was 0.03 per million adults. When combined with the literature, 33 @entity1 were identified of which 28 were male (85%). The median age was 63  years, and 13 (42%) were immunocompromised, which consisted of alcoholism in 7 (21%). Animal contact could be established in 29 of 30 @entity1 (93%) and consisted of @entity235 bites in 22 of 29 (76%). One @entity1 died (3%) and 8 had neurological sequelae upon discharge (25%), most often @entity393 (n  =  6, 19%). @entity55752 @entity693 is associated with @entity235 bites. Although mortality is relatively low, survivors often have neurological sequelae.

title: @entity55752 XXXX : Three Cases and a Review of the Literature.

answer: @entity693 :: (MESH:D008581,Disease) :: ['Meningitis']


abstract: PURPOSE OF REVIEW: @entity102 ( @entity102 ) is a common heterogenous @entity74 affecting @entity1 and adults. The exact mechanism is not completely understood. In this review, we aim to summarize our recent findings regarding etiologies and pathogenesis of @entity102 in @entity1 and review recent studies investigating inflammatory patterns in the upper airways in @entity1 and adults with @entity102 . RECENT FINDINGS: There are only a few small studies measuring upper airway @entity32 in @entity1 with @entity102 . These studies demonstrated more toward eosinophilic and T-cell driven inflammatory pattern. Cytokine patterns in upper airways seem to correlate with @entity565 symptoms in @entity1 with @entity102 . Adult studies demonstrate eosinophilic and Th-2 (T helper-1) driven @entity32 in @entity102 with @entity480 and @entity1198 (T helper-2) driven @entity32 in @entity102 without @entity480 . SUMMARY: Current knowledge about the characteristics of tissue @entity32 in upper airways in @entity1 with @entity102 is limited. More studies are needed to better understand the pathogenesis and better define the subgroups of @entity102 . The findings of such studies will lead to identifying the biological targets to treat this condition.

title: Direct measurement of upper airway @entity32 in @entity1 with chronic rhinosinusitis: implications for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['CRS', 'Chronic rhinosinusitis']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['multifactorial disorder']

entities_list: @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: PURPOSE OF REVIEW: @entity102 ( @entity102 ) is a common heterogenous @entity74 affecting @entity1 and adults. The exact mechanism is not completely understood. In this review, we aim to summarize our recent findings regarding etiologies and pathogenesis of @entity102 in @entity1 and review recent studies investigating inflammatory patterns in the upper airways in @entity1 and adults with @entity102 . RECENT FINDINGS: There are only a few small studies measuring upper airway @entity32 in @entity1 with @entity102 . These studies demonstrated more toward eosinophilic and T-cell driven inflammatory pattern. Cytokine patterns in upper airways seem to correlate with @entity565 symptoms in @entity1 with @entity102 . Adult studies demonstrate eosinophilic and Th-2 (T helper-1) driven @entity32 in @entity102 with @entity480 and @entity1198 (T helper-2) driven @entity32 in @entity102 without @entity480 . SUMMARY: Current knowledge about the characteristics of tissue @entity32 in upper airways in @entity1 with @entity102 is limited. More studies are needed to better understand the pathogenesis and better define the subgroups of @entity102 . The findings of such studies will lead to identifying the biological targets to treat this condition.

title: Direct measurement of upper airway XXXX in @entity1 with chronic rhinosinusitis: implications for @entity565 .

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: PURPOSE OF REVIEW: @entity102 ( @entity102 ) is a common heterogenous @entity74 affecting @entity1 and adults. The exact mechanism is not completely understood. In this review, we aim to summarize our recent findings regarding etiologies and pathogenesis of @entity102 in @entity1 and review recent studies investigating inflammatory patterns in the upper airways in @entity1 and adults with @entity102 . RECENT FINDINGS: There are only a few small studies measuring upper airway @entity32 in @entity1 with @entity102 . These studies demonstrated more toward eosinophilic and T-cell driven inflammatory pattern. Cytokine patterns in upper airways seem to correlate with @entity565 symptoms in @entity1 with @entity102 . Adult studies demonstrate eosinophilic and Th-2 (T helper-1) driven @entity32 in @entity102 with @entity480 and @entity1198 (T helper-2) driven @entity32 in @entity102 without @entity480 . SUMMARY: Current knowledge about the characteristics of tissue @entity32 in upper airways in @entity1 with @entity102 is limited. More studies are needed to better understand the pathogenesis and better define the subgroups of @entity102 . The findings of such studies will lead to identifying the biological targets to treat this condition.

title: Direct measurement of upper airway @entity32 in XXXX with chronic rhinosinusitis: implications for @entity565 .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: The understanding of prognostic factors has facilitated stratification of risk groups in differentiated @entity259 . The prognostic factors have clearly identified the risk groups as low, intermediate, and high risk. Risk group categorization has facilitated a selective surgical approach for @entity259 . METHODS: A retrospective review of 228 @entity1 with follicular @entity259 was undertaken. Various prognostic factors and risk groups were analyzed. Univariate and multivariate analyses were performed, and the survival curves were plotted by the Kaplan-Meier method. Fifty-nine (26%) @entity1 presented with H  rthle cell histology. The risk groups revealed 62 @entity1 in the low, 84 in the intermediate, and 82 in the high risk groups. RESULTS: The 10-year survival for low, intermediate, and high risk groups was 98%, 88%, and 56%, respectively, and the 20-year survival for the same groups was 97%, 87%, and 49%, respectively. Adverse prognostic factors included age older than 45 years (p < 0.001), H  rthle cell variety (p = 0.05), extrathyroidal extension, @entity5 size exceeding 4 cm, and the presence or absence of distant @entity3 (p < 0.001). Gender, focality, and presence of lymph node @entity3 had no significant impact on prognosis. CONCLUSIONS: @entity1 in the low risk group have excellent survival, whereas the high risk group behaves poorly. Appropriate selection of treatment for the @entity66 and adjuvant therapy should be considered on the basis of the prognostic factors and risk group analysis.

title: Prognostic factors and risk group analysis in follicular XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid carcinoma', 'carcinoma of the thyroid']

answer: @entity259 :: (MESH:D013964,Disease) :: ['carcinoma of the thyroid']


abstract: UNASSIGNED: The purpose of this study was to examine whether or not lower limb sprint interval training following arm resistance training influences training response of arm muscle strength and @entity1184 . Twenty @entity1 participated in this study. We divided subjects into @entity3013 ( @entity3013 , n=6) and concurrent training group (CT, n=6). The @entity3013 program was designed to induce muscular @entity1184 (3 sets x 10 repetitions (reps) at 80% 1 repetition maximum [1RM] of arm curl exercise), and was performed in an 8-week training schedule carried out 3 times per week on nonconsecutive days. Subjects assigned to the CT group performed identical protocols as strength training (ST) and modified sprint interval training (4 sets of 30-s maximal effort, separated in 4m 30-s rest intervals) on the same day. Pre- and post-test maximal @entity26 consumption (VO2max), muscle cross-sectional area ( @entity10002 ), and 1RM were measured. Significant increase in VO2max from pre- to post-test was observed in the CT group (p=0.010, ES=1.84), but not in the @entity3013 group (p= 0.559, ES= 0.35). Significant increase in @entity10002 from pre- to post-test was observed in the @entity3013 group (p=0.030, ES=1.49), but not in the CT group (p= 0.110, ES= 1.01). Significant increase in 1RM from pre- to post-test was observed in the @entity3013 group (p= 0.021, ES= 1.57), but not in the CT group (p= 0.065, ES= 1.19). In conclusion, our data indicate that concurrent lower limb sprint interval training interfere with arm muscle @entity1184 and strength.

title: The effect of high-intensity interval cycling sprints subsequent to arm-curl exercise on upper-body muscle strength and XXXX : A pilot study.

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3013 :: ('MESH:D060467', 'Disease') :: ['resistance training group', 'RT']

answer: @entity1184 :: (MESH:D006984,Disease) :: ['hypertrophy']


abstract: 1. In @entity4774 / @entity4485 anaesthetized male @entity35 , the hypothalamus and pituitary stalk were exposed by a transpharyngeal approach. Cells recorded with glass micro-electrodes from the ventral hypothalamus near the bifurcation of the internal carotid artery were identified as supraoptic neurones only when their antidromic action potential evoked at constant latency by stimulation of the pituitary stalk was cancelled by collision with a spontaneously occurring action potential.2. More than 80% of the identified cells were spontaneously active. The frequency of firing was often slow (under 1 Hz) and rather irregular. More than half the cells, however, had a more distinctive firing pattern which recurred every 1-3 min and consisted of a period of low or absent activity alternating with periods of quite marked discharge which occasionally exceeded 20 Hz. This periodicity was retained when the over-all activity was enhanced by an intracarotid injection of 0.2 @entity1 % (w/v) @entity1219 .3. Of fifty-two cells tested, thirty-six were excited by @entity934 applied by iontophoresis from a multibarrelled micropipette with average ejection currents of 35 +/- 5 nA (S.D. of thirty-six observations). Ten of these cells were also excited by @entity1239 applied with similar currents.

title: The activity of identified supraoptic neurones and their response to XXXX applied by iontophoresis.

entities_list: @entity4485 :: ('MESH:D010424', 'Chemical') :: ['pentobarbitone']

entities_list: @entity4774 :: ('MESH:D014520', 'Chemical') :: ['urethane']

entities_list: @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity934 :: (MESH:D000109,Chemical) :: ['acetylcholine']


abstract: @entity890 is uncommon. One of the main problems in the treatment of @entity890 has been the lack of accuracy of diagnostic tests. Now, with the use of computed tomographic scanning with and without @entity6161 in the subarachnoid space, this accuracy has greatly improved. Computed tomography scanning can demonstrate the type and level of the lesion even when the myelographic study is negative. We have reviewed 280 cases; a peak incidence was noted in the fourth decade with 75% of the protruded discs occurring below T-8. Back @entity158 was the most common presenting symptom followed by @entity132 . By the time of diagnosis, 70% of the @entity1 had signs of @entity1745 . A small group of @entity1 could be identified that invariably had a good prognosis. They had a history of @entity130 , symptoms lasting less than a month, and soft disc herniation. Regarding the results of surgical treatment, there was a success rate ranging from 57% for decompressive laminectomy to over 80% for the posterolateral, lateral, and transthoracic approaches.

title: XXXX . Improved diagnosis with computed tomographic scanning and a review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity132 :: ('MESH:D010468', 'Disease') :: ['sensory disturbances']

entities_list: @entity6161 :: ('MESH:D008793', 'Chemical') :: ['metrizamide']

entities_list: @entity1745 :: ('MESH:D013117', 'Disease') :: ['spinal cord compression']

entities_list: @entity890 :: ('MESH:D007405', 'Disease') :: ['thoracic disc herniation', 'Thoracic disc herniation']

answer: @entity890 :: (MESH:D007405,Disease) :: ['Thoracic disc herniation']


abstract: The effects of acute pressure overload of the right and left ventricle on the left ventricular hemodynamics, coronary circulation, and myocardial metabolism in @entity235 were investigated by banding of the main pulmonary artery and by producing two models of aortic constriction with (type B) and without (type A) aortocoronary bypass. Pulmonary artery banding (left ventricular preload reduction) showed right ventriculr systolic pressure (RVSP), right ventricular end-diastolic pressure (RVEDP), and right ventricular dP/dtmax significantly elevated, but left ventricular systolic pressure (LVSP), left ventricular (dP/dtmax)/IIP slightly decreased, contrary to a slight increase of left ventricular end-diastolic pressure (LVEDP). The blood flow of the left coronary circumflex artery (CBF) was slightly decreased, but the aortic blood flow (AoF) and left ventricular work per minute (LVW) were significantly reduced. As to myocardial metabolism, the coronary arteriovenous difference (delta) of @entity1735 , mainly @entity413 (G) and @entity880 (L), increased, while that of non-esterified @entity844 (NEFA) showed a significant reduction. @entity1498 (left ventricular afterload increase) showed, both in types A and B, left ventricular systolic pressure, left ventricular end-diastolic pressure, and left ventricular work per minute were increased. However, aortic systolic and diastolic pressure were significantly decreased. The blood flow of the left coronary circumflex artery tended to increase in both types. The myocardial @entity1735 uptake tended to increase after aortic constriction in both types. However, the uptake of non-esterified @entity844 was increased after aortic constriction in type A, but decreased in type B. This difference in uptake of non-esterified @entity844 might be induced by the difference of the functional state of the left ventricle.

title: Effects of right and left ventricular pressure overload on left ventricular function and metabolism in XXXX .

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity1498 :: ('MESH:D001017', 'Disease') :: ['Aortic coarctation']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity235 :: (9615,Species) :: ['dogs']


abstract: BACKGROUND: Precocious cervical ripening, as defined by cervical @entity3207 on transvaginal sonography, has prompted a broad evaluation of secondary strategies (such as cerclage, vaginal @entity1420 , or a cervical pessary) to prevent @entity3152 . However, there is still a lack  of direct comparisons between individual treatments or their combinations. OBJECTIVE: We sought to compare at-risk @entity1 and screening @entity1 who had been treated with cervical pessary alone with @entity1 who had been treated with pessary plus vaginal @entity1420 . STUDY DESIGN: This is a pre- and postintervention cohort study from a @entity3152 clinic where placement of a cervical pessary has been the standard treatment since 2008 for at-risk @entity1 defined by (1) a history of spontaneous @entity600 at <37 weeks of gestation, (2) conization, or (3) a cerclage because of a previous short cervical length of <3rd percentile and, additionally, with a cervical length of <10th percentile in the ongoing pregnancy. @entity1 who did not meet the criteria for the "at risk" group, but who had a cervical length of <3rd percentile comprised the screening group. From July 2011 onward, vaginal @entity1420 (200 mg, suppositories) was prescribed in addition to the pessary. Both at-risk @entity1 (n  = 55) and screening @entity1 (n  = 51) were treated at the time of diagnosis. The primary outcome was the rate of preterm deliveries at <34 weeks of gestation. Secondary outcomes included deliveries at <28, <32, and <37 weeks of gestation, the days from start of therapy until delivery, a composite index of neonatal outcome, and the number of days in the neonatal intensive care unit. Primary and secondary outcomes were compared between groups with the use of multivariable models to adjust for possible confounders. RESULTS: Delivery at <34 weeks of gestation occurred in 17 of 53 @entity1 (32.1%) who were treated with pessary plus @entity1420 , compared with 13 of 53 @entity1 (24.5%) who were treated with pessary alone (P  = .57). Similarly, there was no difference in the rate of @entity3152 at <28, <32, or <37 weeks of gestation. The composite poor neonatal outcome was 15.1% in the pessary group vs 18.9% in the combined group (P  = .96). The mean duration of stay in the neonatal intensive care unit was 46.5 days (range, 9-130 days) in the combined vs  52.0 days (range, 3-151 days) in the pessary group (P < .001). CONCLUSION: In this cohort study, treatment of precocious cervical ripening with cervical pessary plus vaginal @entity1420 did not reduce the rates of @entity3152 at <28, <32, <34, or <37 weeks of gestation compared with pessary alone. The neonatal intensive care use was shorter in @entity1 who received additional vaginal @entity1420 , although there was no difference in composite poor neonatal outcome. These preliminary results may serve as a pilot for future trials and provide a basis for treatment until larger trials are completed.

title: Vaginal XXXX combined with cervical pessary: A chance for pregnancies at risk for @entity600 ?

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery', 'preterm labor']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth']

entities_list: @entity3207 :: ('MESH:C535850', 'Disease') :: ['shortening']

answer: @entity1420 :: (MESH:D011374,Chemical) :: ['progesterone']


abstract: BACKGROUND: Precocious cervical ripening, as defined by cervical @entity3207 on transvaginal sonography, has prompted a broad evaluation of secondary strategies (such as cerclage, vaginal @entity1420 , or a cervical pessary) to prevent @entity3152 . However, there is still a lack  of direct comparisons between individual treatments or their combinations. OBJECTIVE: We sought to compare at-risk @entity1 and screening @entity1 who had been treated with cervical pessary alone with @entity1 who had been treated with pessary plus vaginal @entity1420 . STUDY DESIGN: This is a pre- and postintervention cohort study from a @entity3152 clinic where placement of a cervical pessary has been the standard treatment since 2008 for at-risk @entity1 defined by (1) a history of spontaneous @entity600 at <37 weeks of gestation, (2) conization, or (3) a cerclage because of a previous short cervical length of <3rd percentile and, additionally, with a cervical length of <10th percentile in the ongoing pregnancy. @entity1 who did not meet the criteria for the "at risk" group, but who had a cervical length of <3rd percentile comprised the screening group. From July 2011 onward, vaginal @entity1420 (200 mg, suppositories) was prescribed in addition to the pessary. Both at-risk @entity1 (n  = 55) and screening @entity1 (n  = 51) were treated at the time of diagnosis. The primary outcome was the rate of preterm deliveries at <34 weeks of gestation. Secondary outcomes included deliveries at <28, <32, and <37 weeks of gestation, the days from start of therapy until delivery, a composite index of neonatal outcome, and the number of days in the neonatal intensive care unit. Primary and secondary outcomes were compared between groups with the use of multivariable models to adjust for possible confounders. RESULTS: Delivery at <34 weeks of gestation occurred in 17 of 53 @entity1 (32.1%) who were treated with pessary plus @entity1420 , compared with 13 of 53 @entity1 (24.5%) who were treated with pessary alone (P  = .57). Similarly, there was no difference in the rate of @entity3152 at <28, <32, or <37 weeks of gestation. The composite poor neonatal outcome was 15.1% in the pessary group vs 18.9% in the combined group (P  = .96). The mean duration of stay in the neonatal intensive care unit was 46.5 days (range, 9-130 days) in the combined vs  52.0 days (range, 3-151 days) in the pessary group (P < .001). CONCLUSION: In this cohort study, treatment of precocious cervical ripening with cervical pessary plus vaginal @entity1420 did not reduce the rates of @entity3152 at <28, <32, <34, or <37 weeks of gestation compared with pessary alone. The neonatal intensive care use was shorter in @entity1 who received additional vaginal @entity1420 , although there was no difference in composite poor neonatal outcome. These preliminary results may serve as a pilot for future trials and provide a basis for treatment until larger trials are completed.

title: Vaginal @entity1420 combined with cervical pessary: A chance for pregnancies at risk for XXXX ?

answer: @entity600 :: (MESH:D000014,Disease) :: ['preterm birth']


abstract: UNASSIGNED: As @entity750 reuptake inhibitor (SRI) use may decrease platelet function, previous research has shown a relationship between SRI use and an increased risk for @entity2981 and @entity548 . The literature regarding the association between SRI use during pregnancy and increased @entity548 at delivery, referred to as postpartum @entity548 (PPH), is mixed. In secondary analyses from two prospective observational studies of pregnant @entity1 with @entity1316 , 263 @entity1 were exposed to an SRI (n  =  51) or not (n  =  212) in the third trimester. To be precise, we used the terminology estimated @entity190 (EBL) >600  cc rather than the term PPH because the current definition of PPH differs. The occurrence of EBL >600  cc was determined using the Peripartum Events Scale (PES) completed from obstetrical records by a blinded medically trained member of the study team. EBL >600  cc occurred in 8.7% of @entity1 in this cohort. There was no statistically significant difference in the rates of EBL >600  cc in the 24  h after delivery in @entity1 taking SRIs during the third trimester (9.8%) compared to non-exposed @entity1 (8.5%). Utilizing generalizing estimating equations, the odds of EBL >600  cc in each group were not significantly different (OR 1.17, CI-0.41-3.32, p  =  0.77). When the SRI group was limited to @entity1 with exposure at the time of delivery, the difference in the odds of EBL >600  cc was unchanged (OR 1.16, CI  =  0.37-3.64, p  =  0.79). In population, both third trimester and use at delivery of SRIs during pregnancy was not associated with an increased risk of excessive @entity190 .

title: Is third trimester @entity750 reuptake inhibitor use associated with postpartum XXXX ?

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'bleeding']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorders']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhage']


abstract: UNASSIGNED: As @entity750 reuptake inhibitor (SRI) use may decrease platelet function, previous research has shown a relationship between SRI use and an increased risk for @entity2981 and @entity548 . The literature regarding the association between SRI use during pregnancy and increased @entity548 at delivery, referred to as postpartum @entity548 (PPH), is mixed. In secondary analyses from two prospective observational studies of pregnant @entity1 with @entity1316 , 263 @entity1 were exposed to an SRI (n  =  51) or not (n  =  212) in the third trimester. To be precise, we used the terminology estimated @entity190 (EBL) >600  cc rather than the term PPH because the current definition of PPH differs. The occurrence of EBL >600  cc was determined using the Peripartum Events Scale (PES) completed from obstetrical records by a blinded medically trained member of the study team. EBL >600  cc occurred in 8.7% of @entity1 in this cohort. There was no statistically significant difference in the rates of EBL >600  cc in the 24  h after delivery in @entity1 taking SRIs during the third trimester (9.8%) compared to non-exposed @entity1 (8.5%). Utilizing generalizing estimating equations, the odds of EBL >600  cc in each group were not significantly different (OR 1.17, CI-0.41-3.32, p  =  0.77). When the SRI group was limited to @entity1 with exposure at the time of delivery, the difference in the odds of EBL >600  cc was unchanged (OR 1.16, CI  =  0.37-3.64, p  =  0.79). In population, both third trimester and use at delivery of SRIs during pregnancy was not associated with an increased risk of excessive @entity190 .

title: Is third trimester XXXX reuptake inhibitor use associated with postpartum @entity548 ?

answer: @entity750 :: (MESH:D012701,Chemical) :: ['serotonin']


abstract: BACKGROUND: Current research has established @entity28 as one of the main modifiable risk factors for @entity73 . However, evidence on the relationships of total and regional body composition measures as well as @entity6288 with cognitive functioning in the older population remains inconsistent. METHODS: Data are based on 1,570 @entity1 from the British Regional Heart Study (BRHS), a cohort of older British @entity1 from 24 British towns initiated in 1978-80, who were re-examined in 2010-12, aged 71-92 years. Cognitive functioning was assessed with the Test-Your-Memory cognitive screening tool. Body composition characteristics assessed using bioelectrical impedance analysis included total fat mass (FM), central FM, peripheral FM, and visceral fat level. @entity6288 was defined using the European Working Group on @entity6288 in Older @entity1 (EWGSOP) definition of severe @entity6288 and the Foundation for the National Institutes of Health (FNIH) @entity6288 project criteria. RESULTS: Among 1,570 @entity1 , 636 (41  %) were classified in the @entity73 ( @entity73 ) and 133 (8  %) in the @entity73 ( @entity73 ) groups. Age-adjusted multinomial logistic regressions showed that compared with @entity1 in the normal cognitive ageing group, those with @entity73 were more likely to have waist circumference >102  cm, BMI >30  kg/m(2), to be in the upper quintile of total FM, central FM, peripheral FM and visceral fat level and to be sarcopenic. The relationships remained significant for total FM (RR   =   2.16, 95  % CI 1.29-3.63), central FM (RR   =   1.85, 95  % CI 1.09-3.14), peripheral FM (RR   =   2.67, 95  % CI 1.59-4.48), visceral fat level (RR   =   2.28, 95  % CI 1.32-3.94), BMI (RR   =   2.25, 95  % CI 1.36-3.72) and waist circumference (RR   =   1.63, 95  % CI 1.05-2.55) after adjustments for alcohol, smoking, social class, physical activity and history of @entity65 or @entity6 . After further adjustments for @entity650 and insulin resistance, central FM, waist circumference and @entity6288 were no longer significantly associated with @entity73 . CONCLUSIONS: Increased levels of peripheral FM, visceral fat level, and BMI are associated with @entity73 among older @entity1 . Distinct pathophysiological mechanisms link regional adipose tissue deposition and cognitive functioning.

title: The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'People', 'people', 'men']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'SCI', 'severe cognitive impairment', 'MCI', 'mild cognitive impairment']

entities_list: @entity6288 :: ('MESH:D055948', 'Disease') :: ['Sarcopenia', 'sarcopenia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: Intestinal chemosensory signaling pathways involving the gustatory G-protein, gustducin, and bitter taste receptors (TAS2R) have been implicated in gut hormone release. Alterations in gut hormone profiles may contribute to the success of bariatric surgery. This study investigated the involvement of the gustatory signaling pathway in the development of diet-induced @entity28 and the therapeutic potential of targeting TAS2Rs to induce body @entity353 . a-gustducin-deficient (a-gust-/-) @entity19 became less @entity28 than @entity164 ( @entity164 ) @entity19 when fed a high-fat diet (HFD). @entity1386 ( @entity1386 ) mass was lower in a-gust-/- @entity19 due to @entity101 as a result of increases in brown adipose tissue (BAT) thermogenic activity, involving increased protein expression of uncoupling protein 1. Intra-gastric treatment of @entity28 and a-gust-/- @entity19 with the bitter agonists @entity20154 (DB) or @entity4807 (Q) during 4 weeks resulted in an a-gustducin-dependent @entity1017 associated with a decrease in food intake (DB), but not involving major changes in gut peptide release. Both @entity1386 and 3T3-F442A pre-adipocytes express TAS2Rs. Treatment of pre-adipocytes with DB or Q decreased differentiation into mature adipocytes. In conclusion, interfering with the gustatory signaling pathway protects against the development of HFD-induced @entity28 presumably through promoting BAT activity. Intra-gastric bitter treatment inhibits @entity1017 , possibly by directly affecting adipocyte metabolism.

title: The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in XXXX .

entities_list: @entity20154 :: ('MESH:C029408', 'Chemical') :: ['denatonium benzoate']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity', 'obese WT']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['increased heat production']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain', 'decrease in body weight gain']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['White adipose tissue', 'WAT']

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: INTRODUCTION: Post-chemotherapy retroperitoneal lymph node dissection (PC-RPLND) is an important tool in the management of advanced germ cell @entity5 , @entity4797 . AIM: We present the 16-year experience with PC-RPLND in a single Irish tertiary referral centre, and compare our results to the major speciality centres worldwide. METHODOLOGY: All 78 @entity1 undergoing PC-RPLND for the treatment of metastatic @entity5 between January 1996 and December 2011 were included. Medical records were reviewed and up to date follow-up obtained from primary referral centres, @entity1 's GPs and individual @entity1 interview. RESULTS: The mean age at diagnosis was 28.5      7  years. Initial pathology included @entity4797 62.8  %, @entity4797 6.4  % and combined 19.2  %. All @entity1 underwent pre-operative chemotherapy. The resection template utilised was bilateral infra-hilar in 29.5  %, unilateral  infra-hilar in 46.2  % and supra-hilar in 20.5  %. Complete abdominal remission was achieved in all but one @entity1 . Additional procedures were required in 38.5  % of @entity1 (n  =  30). Clavien Dindo grade three or four complications were seen in 8.9  %, including five @entity1 who required early reoperation. Histology of RPLND specimen showed mature @entity44 (41  %) and active @entity5 (11.5  %). Follow-up data were available for 66 @entity1 (85  %). Median follow-up was 101 (11-207) months. Nine @entity1 relapsed with median time to relapse 15 (8-60) months. Overall 5-year survival rate was 95.2  % (four deaths). CONCLUSION: In this relatively small series due to small population and low disease incidence, we have shown acceptable peri-operative course, morbidity and oncological outcomes with PC-RPLND compared to major international centres.

title: Post-chemotherapy retroperitoneal lymph node dissection in the management of metastatic XXXX : the 16-year experience in an Irish setting.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'testis cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratoma']

entities_list: @entity4797 :: ('MESH:D018239', 'Disease') :: ['particularly non-seminoma', 'non-seminoma', 'seminoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['testis cancer']


abstract: OBJECTIVES: The 2012 international guidelines state that surgery should be considered for all surgically fit @entity1 with @entity788 ( @entity1157 )/mixed @entity4929 ( @entity4929 ). This study evaluated the follow-up results of @entity1157 /mixed @entity4929 and risk factors for progression or @entity5 . METHODS: @entity1 with @entity1157 /mixed @entity4929 were retrospectively enrolled and divided into surgical and nonsurgical groups. These 2 groups were compared and further categorized as progression/ @entity5 or not. In the nonsurgical group, disease progression was defined as radiologic @entity5 growth or adjacent organ invasion. RESULTS: Data from 101 @entity1 (73 males; mean [SD] age, 66.3   [9.1]   years), including 27 and 74 in the nonsurgical and surgical groups, respectively, were analyzed. Mural nodules were more frequently detected in the surgical group (7.4% vs 31.1%, P = 0.018), whereas more multifocal cysts were observed in the nonsurgical group (40.7% vs 20.3%, P = 0.037). Forty-one @entity1 (40.6%) showed progression or @entity5 . Multivariate analysis showed that main pancreatic duct of 10 mm or greater (odds ratio, 4.368; P = 0.024) and pre-existing @entity6 (odds ratio, 3.077; P = 0.046) were independent risk factors for progression or @entity5 . CONCLUSIONS: A watchful waiting strategy could be feasible for some @entity1 with @entity1157 /mixed @entity4929 , particularly those with a main pancreatic duct of less than 10 mm and without @entity6 .

title: Risk Factors for Progression or Malignancy in Main-Duct and Mixed-Type XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic main-duct']

entities_list: @entity4929 :: ('MESH:C565310', 'Disease') :: ['IPMNs', 'intraductal papillary mucinous neoplasms']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy']

answer: @entity788 :: (MESH:D010190,Disease) :: ['Intraductal Papillary Mucinous Neoplasm of the Pancreas']


abstract: OBJECTIVE: To explore and compare barriers to early presentation of self-discovered @entity0 in @entity7643 . DESIGN: A qualitative interview study with thematic analysis of transcripts. @entity1 : 67 @entity1 with self-discovered breast symptoms were included in the analysis. Of these, 36% were of Malay ethnicity, 39% were Chinese and 25% Indian, with an average age of 58   years (range 24-82   years). The number of @entity1 diagnosed at early stages of @entity5 almost equalled those at advanced stages. Approximately three-quarters presented with a painless lump, one-quarter experienced a @entity158 lump and 10% had atypical symptoms. SETTING: University hospital setting in @entity7643 . RESULTS: @entity1 revealed barriers to early presentation not previously reported: the poor quality of online website information about breast symptoms, financial issues and the negative influence of relatives in both countries, while perceived poor quality of care and services in state-run hospitals and misdiagnosis by healthcare professionals were reported in Malaysia. The pattern of presentation by ethnicity remained unchanged where more Malay delayed help-seeking and had more @entity5 compared to Chinese and Indian @entity1 . CONCLUSIONS: There are few differences in the pattern of presentation and in the reported barriers to seek medical care after symptom discovery between @entity7643 despite their differing economic status. Strategies to reduce delayed presentation are: a need to improve knowledge of disease, symptoms and causes, quality of care and services, and quality of online information; and addressing fear of diagnosis, treatment and hospitalisation, with more effort focused on the Malay ethnic group. Training is needed to avoid missed diagnoses and other factors contributing to delay among health professionals.

title: Barriers to early presentation of self-discovered XXXX in @entity7643 : a qualitative multicentre study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'PARTICIPANTS']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'advanced cancer']

entities_list: @entity7643 :: ('MESH:D019595', 'Disease') :: ['Singapore and Malaysia']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: OBJECTIVE: To explore and compare barriers to early presentation of self-discovered @entity0 in @entity7643 . DESIGN: A qualitative interview study with thematic analysis of transcripts. @entity1 : 67 @entity1 with self-discovered breast symptoms were included in the analysis. Of these, 36% were of Malay ethnicity, 39% were Chinese and 25% Indian, with an average age of 58   years (range 24-82   years). The number of @entity1 diagnosed at early stages of @entity5 almost equalled those at advanced stages. Approximately three-quarters presented with a painless lump, one-quarter experienced a @entity158 lump and 10% had atypical symptoms. SETTING: University hospital setting in @entity7643 . RESULTS: @entity1 revealed barriers to early presentation not previously reported: the poor quality of online website information about breast symptoms, financial issues and the negative influence of relatives in both countries, while perceived poor quality of care and services in state-run hospitals and misdiagnosis by healthcare professionals were reported in Malaysia. The pattern of presentation by ethnicity remained unchanged where more Malay delayed help-seeking and had more @entity5 compared to Chinese and Indian @entity1 . CONCLUSIONS: There are few differences in the pattern of presentation and in the reported barriers to seek medical care after symptom discovery between @entity7643 despite their differing economic status. Strategies to reduce delayed presentation are: a need to improve knowledge of disease, symptoms and causes, quality of care and services, and quality of online information; and addressing fear of diagnosis, treatment and hospitalisation, with more effort focused on the Malay ethnic group. Training is needed to avoid missed diagnoses and other factors contributing to delay among health professionals.

title: Barriers to early presentation of self-discovered @entity0 in XXXX : a qualitative multicentre study.

answer: @entity7643 :: (MESH:D019595,Disease) :: ['Singapore and Malaysia']


abstract: INTRODUCTION: @entity2885 ( @entity2885 ) is associated with high mortality rate, up to 25%. There is still conflicting reports regarding the most appropriate management, conservative versus nephrectomy. OBJECTIVE: To describe the outcome of @entity1 with @entity2885 . METHODS: We retrospectively reviewed the medical records of @entity1 diagnosed with @entity2885 by computed tomography from three tertiary institutes in Jeddah, Saudi Arabia. Type of management was classified as conservative and surgical. The conservative includes medical and minimally invasive procedures, such as percutaneous drainage and nephrostomy. The surgical which is nephrectomy. The outcome observed was preservation of the kidney function or @entity1 's life. RESULTS: A total of 10 @entity1 were included (9 females and 1 male), median age was 55 years and 63% were @entity6 . The most common presentation was @entity812 (100%), @entity221 (75%), and @entity391 (63%). The most common organism isolated was @entity526 . Nephrectomy was not associated with increased survival rate, while conservative management was associated with a good outcome, less morbidity (not dialysis-dependent). CONCLUSION: Nephrectomy was not associated with high survival rate. @entity1 managed conservatively had a better overall performance and better survival. This study will add to other studies, which are encouraging conservative management.

title: XXXX : Is nephrectomy warranted?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity812 :: ('MESH:D021501', 'Disease') :: ['flank pain']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['Emphysematous pyelonephritis', 'EPN']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity2885 :: (MESH:D011704,Disease) :: ['Emphysematous pyelonephritis']


abstract: PURPOSE: @entity693 is among the most common @entity281 affecting the central nervous system. It can be difficult to determine the exact pathogen responsible for the @entity281 and @entity1 are often treated with empiric antibiotics. This study was conducted to identify the most common clinical characteristics of @entity693 in @entity1 and evaluate the diagnostic efficacy of reverse transcriptase-polymerase chain reaction (RT-PCR) for early detection of an enterovirus. METHODS: We analyzed the medical records of @entity1 admitted to Korea University Medical Center and diagnosed with @entity693 on the basis of cerebrospinal fluid (CSF) analysis and RT-PCR from CSF and other samples from January 2010 to August 2013. RESULTS: A total of 333 @entity1 were enrolled and classified into four groups based on diagnosis: @entity693 (n=110), @entity4008 (n=23), other @entity1393 (n=36), and unknown etiology (n=164). @entity1 with @entity4008 were younger than those in the other groups (P<0.001). Pleocytosis in CSF was similar across all groups. Of @entity1 in the @entity693 group, 92.7% were diagnosed based on RT-PCR findings. Mean length of hospital stay for @entity1 with @entity693 was 6.08 days, which was significantly shorter than that for @entity1 with @entity693 of bacterial etiology (19.73 days, P<0.001). CONCLUSION: Diagnosis of @entity693 before viral culture results are available is possible using RT-PCR. Accurate diagnosis reduces the length of hospital stay and helps to avoid unnecessary empiric antibiotic treatment.

title: Analysis of clinical information and reverse transcriptase-polymerase chain reaction for early diagnosis of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity4008 :: ('MESH:D016920', 'Disease') :: ['bacterial meningitis']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['Meningitis', 'enteroviral meningitis', 'meningitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity1393 :: ('MESH:D008587', 'Disease') :: ['viral meningitis']

answer: @entity693 :: (MESH:D008581,Disease) :: ['enteroviral meningitis']


abstract: BACKGROUND: The purpose of current study is to evaluate the association between physical @entity410 level and the prevalence of @entity209 ( @entity209 ) in a Korean elderly population. METHODS: A cross-sectional study measuring physical @entity410 and components of @entity209 in a health promotion center of a general hospital for routine health check-ups. A total of 227 subjects  >60  years old agreed to participate. A lifestyle questionnaire that included cigarette smoking, @entity285 consumption, and physical activity was checked. Body weight, height, blood pressure, fasting @entity413 , total @entity165 , @entity1674 , high density lipoprotein- @entity165 , low density lipoprotein- @entity165 , C-reactive protein, and glycated hemoglobin were measured. Muscular strength was assessed by measuring grasping power. Muscular endurance was evaluated using a sit-up test. Cardiopulmonary @entity410 was assessed via the Tecumseh step test (measuring hear rates at 1  min post-exercise). RESULTS: The highest tertile muscular endurance group (sit-ups  >15 in @entity1 ,  >10 in @entity1 ) was 0.37 times less likely to have @entity209 [95  % confidence interval (CI) 0.17-0.84; p  =  0.036] compared to that in the lowest tertile group (<11 in @entity1 , 0 in @entity1 ), and the highest tertile in the cardiopulmonary @entity410 group (heart rate at rest  >91/min in @entity1 ,  >92/min in @entity1 ) was 2.81 times more likely to have @entity209 (95  % CI 1.27-6.18; p  =  0.038) compared to that in the lowest tertile group (<81/min in @entity1 ,  <80/min in @entity1 ). CONCLUSIONS: Cardiopulmonary @entity410 and muscular endurance were related to @entity209 in a Korean elderly population after adjusting for age, sex, current smoker, current @entity285 drinking, and physical activity. Older adults should be encouraged to increase their cardiopulmonary @entity410 and muscular endurance.

title: The association among three aspects of physical XXXX and @entity209 in a Korean elderly population.

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['MS', 'metabolic syndrome']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity410 :: (MESH:D012640,Disease) :: ['fitness']


abstract: BACKGROUND: The purpose of current study is to evaluate the association between physical @entity410 level and the prevalence of @entity209 ( @entity209 ) in a Korean elderly population. METHODS: A cross-sectional study measuring physical @entity410 and components of @entity209 in a health promotion center of a general hospital for routine health check-ups. A total of 227 subjects  >60  years old agreed to participate. A lifestyle questionnaire that included cigarette smoking, @entity285 consumption, and physical activity was checked. Body weight, height, blood pressure, fasting @entity413 , total @entity165 , @entity1674 , high density lipoprotein- @entity165 , low density lipoprotein- @entity165 , C-reactive protein, and glycated hemoglobin were measured. Muscular strength was assessed by measuring grasping power. Muscular endurance was evaluated using a sit-up test. Cardiopulmonary @entity410 was assessed via the Tecumseh step test (measuring hear rates at 1  min post-exercise). RESULTS: The highest tertile muscular endurance group (sit-ups  >15 in @entity1 ,  >10 in @entity1 ) was 0.37 times less likely to have @entity209 [95  % confidence interval (CI) 0.17-0.84; p  =  0.036] compared to that in the lowest tertile group (<11 in @entity1 , 0 in @entity1 ), and the highest tertile in the cardiopulmonary @entity410 group (heart rate at rest  >91/min in @entity1 ,  >92/min in @entity1 ) was 2.81 times more likely to have @entity209 (95  % CI 1.27-6.18; p  =  0.038) compared to that in the lowest tertile group (<81/min in @entity1 ,  <80/min in @entity1 ). CONCLUSIONS: Cardiopulmonary @entity410 and muscular endurance were related to @entity209 in a Korean elderly population after adjusting for age, sex, current smoker, current @entity285 drinking, and physical activity. Older adults should be encouraged to increase their cardiopulmonary @entity410 and muscular endurance.

title: The association among three aspects of physical @entity410 and XXXX in a Korean elderly population.

answer: @entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']


abstract: Between 1966 and 1977, 55 @entity1 at Barnes Hospital were proven to have manifestations of @entity3219 . Five @entity1 had @entity358 , four of whom demonstrated unusually severe disease. Disseminated @entity3219 was documented in 19 cases. Four of these @entity1 demonstrated dissemination during a severe and protracted but self-limited illness. The other 15 @entity1 had progressive disease. Most of these @entity1 were immune compromised and presented with fever of unknown origin. Therapy most benefited those who completed a course of greater than or equal to 1.5 gm of @entity2379 . @entity1030 was documented in 14 individuals. Large (> 1.5 cm), solitary @entity5474 , excised from 14 @entity1 , were found to consist of exuberant @entity738 containing @entity375 . Organisms were recovered from pleural effusions of two @entity1 and demonstrated histologically in the tissue of one individual who presented with fibrosing @entity1764 .

title: The spectrum of XXXX in a general hospital: a review of 55 cases diagnosed at Barnes Hospital between 1966 and 1977.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas']

entities_list: @entity1764 :: ('MESH:D008480', 'Disease') :: ['mediastinitis']

entities_list: @entity5474 :: ('MESH:D003074', 'Disease') :: ['pulmonary coin lesions']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['acute pulmonary histoplasmosis']

entities_list: @entity3219 :: ('MESH:D006660', 'Disease') :: ['histoplasmosis']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['Chronic pulmonary histoplasmosis']

answer: @entity3219 :: (MESH:D006660,Disease) :: ['histoplasmosis']


abstract: The acute syndromes and CT findings are described in 26 cases of spontaneous @entity1779 . @entity548 (11 cases) caused severe @entity158 around the ipsilateral eye and dense @entity1805 . Left temporal @entity548 (7 cases) began with mild @entity158 in or just anterior to the ear, @entity13523 with poor auditory comprehension but relatively good repetition, and a @entity227 subtending less than a @entity1805 . Frontal @entity548 (4 cases) caused a distinctive syndrome beginning with severe contralateral arm @entity425 , minimal leg and face @entity425 , and frontal @entity10 . @entity548 (3 cases) began with anterior temporal ("temple") @entity10 and @entity51 , sometimes involving the trunk to the midline. One @entity1 had a right temporal @entity548 . @entity548 in the same region produce similar clinical syndromes. @entity10 is a first and prominent symptom. A rapid but not instantaneous onset over several minutes, when combined with one of the typical syndromes, suggests lobar @entity548 rather than other types of @entity64 . Ancillary investigations (including CT scanning, angiography in 11 @entity1 , and autopsy in 4) disclosed 2 @entity1 with @entity548 diatheses due to @entity1229 , 2 with @entity2758 , and 1 with @entity3 . Only 8 of the 26 @entity1 had chronic @entity101 (blood pressure greater than 130/85 mm Hg), suggesting that @entity101 is not an etiological factor in most lobar @entity548 .

title: XXXX : acute clinical syndromes in 26 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual deficit']

entities_list: @entity2758 :: ('MESH:D001165', 'Disease') :: ['arteriovenous malformations']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['Parietal hemorrhage', 'Spontaneous lobar hemorrhage and branch artery embolism', 'hemorrhage', 'Occipital hemorrhage', 'bleeding', 'hemorrhages']

entities_list: @entity13523 :: ('MESH:D001041', 'Disease') :: ['fluent dysphasia']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['hemisensory deficit']

entities_list: @entity1805 :: ('MESH:D006423', 'Disease') :: ['hemianopia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic tumor']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache', 'headache']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hemorrhage']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']

answer: @entity1779 :: (MESH:D002543,Disease) :: ['Lobar cerebral hemorrhages']


abstract: Because of joint @entity548 , severe @entity447 subjects often have limitations in their daily activities. Current orthopaedic scores (OJS) in @entity447 miss mild @entity73 and only pick up severe alterations. Twelve young severe haemophiliacs (20.25        1.9  years of age), were evaluated for OJS as well as for indices employed in @entity309 [28-joint Disease Activity Score (DAS-28), Ritchie index, Health Assessment Questionnaire (HAQ), @entity227 ( @entity227 )], @entity1691 [Bath @entity1691 Activity Index (BASDAI), HAQ, @entity227 ] and @entity571 [ @entity3331 and @entity571 Outcome Score (KOOS), @entity227 ]. Twenty-four matched apparently healthy subjects and 29 subjects with @entity5144 ( @entity5144 ) with @entity14361 (one to three swollen joints) served as controls. In addition to the impairment of @entity2720 (elbow, in five of five in those on-demand treatment; three, elbows; four, knee in those on secondary prophylaxis), HAQ (mean 0.71        0.95) and @entity227 (3.12        2.36) documented a quality of life and a perception of @entity158 in haemophiliacs similar to that of @entity5144 subjects (p   =   0.061 and p   =   0.063, respectively). Their Ritchie index did not differ from that of subjects with @entity5144 (5.75        8.1 vs 7.73        9.22; p   =   0.408), nor did the BASDAI score with respect to @entity5144 @entity1 (p   =   0.105). Six of 12 haemophiliacs (50%) had KOOS values from 70 to 50 (significant function @entity73 ); 3 of 12 (25%) showed DAS-28 values >3.2 (moderate disease activity), 2 of 12 (16.6%) severe disease activity (>5.1). All these indices significantly correlated with @entity227 and HAQ in @entity447 subjects. A rheumatologic assessment may help identify early @entity66 and subclinical @entity66 not usually studied (not target joint) in haemophiliacs. These pilot data provide the rationale for testing a systemic involvement in haemophiliacs by means of high-tech imaging and to start early-onset prophylaxis/treatment in this setting.

title: Assessing joint involvement in @entity447 by clinical rheumatologic scores. A pilot study on similarities with subjects with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual analogue scale', 'VAS']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis', 'osteoarthritis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhages']

entities_list: @entity447 :: ('MESH:D006467', 'Disease') :: ['haemophilia']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['polyarticular disease', 'abnormalities involving joints']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['joint impairments', 'joint impairment']

entities_list: @entity3331 :: ('MESH:D007718', 'Disease') :: ['Knee injury']

entities_list: @entity5144 :: ('MESH:D015535', 'Disease') :: ['PsA', 'psoriatic arthritis']

entities_list: @entity14361 :: ('MESH:C566895', 'Disease') :: ['oligoarticular involvement']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['Ankylosing Spondylitis Disease', 'spondyloarthritis']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['target joints']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

answer: @entity5144 :: (MESH:D015535,Disease) :: ['psoriatic arthritis']


abstract: Because of joint @entity548 , severe @entity447 subjects often have limitations in their daily activities. Current orthopaedic scores (OJS) in @entity447 miss mild @entity73 and only pick up severe alterations. Twelve young severe haemophiliacs (20.25        1.9  years of age), were evaluated for OJS as well as for indices employed in @entity309 [28-joint Disease Activity Score (DAS-28), Ritchie index, Health Assessment Questionnaire (HAQ), @entity227 ( @entity227 )], @entity1691 [Bath @entity1691 Activity Index (BASDAI), HAQ, @entity227 ] and @entity571 [ @entity3331 and @entity571 Outcome Score (KOOS), @entity227 ]. Twenty-four matched apparently healthy subjects and 29 subjects with @entity5144 ( @entity5144 ) with @entity14361 (one to three swollen joints) served as controls. In addition to the impairment of @entity2720 (elbow, in five of five in those on-demand treatment; three, elbows; four, knee in those on secondary prophylaxis), HAQ (mean 0.71        0.95) and @entity227 (3.12        2.36) documented a quality of life and a perception of @entity158 in haemophiliacs similar to that of @entity5144 subjects (p   =   0.061 and p   =   0.063, respectively). Their Ritchie index did not differ from that of subjects with @entity5144 (5.75        8.1 vs 7.73        9.22; p   =   0.408), nor did the BASDAI score with respect to @entity5144 @entity1 (p   =   0.105). Six of 12 haemophiliacs (50%) had KOOS values from 70 to 50 (significant function @entity73 ); 3 of 12 (25%) showed DAS-28 values >3.2 (moderate disease activity), 2 of 12 (16.6%) severe disease activity (>5.1). All these indices significantly correlated with @entity227 and HAQ in @entity447 subjects. A rheumatologic assessment may help identify early @entity66 and subclinical @entity66 not usually studied (not target joint) in haemophiliacs. These pilot data provide the rationale for testing a systemic involvement in haemophiliacs by means of high-tech imaging and to start early-onset prophylaxis/treatment in this setting.

title: Assessing joint involvement in XXXX by clinical rheumatologic scores. A pilot study on similarities with subjects with @entity5144 .

answer: @entity447 :: (MESH:D006467,Disease) :: ['haemophilia']


abstract: @entity1161 ( @entity1161 ) for @entity1313 is associated with @entity137 which may be a result of damage to neural progenitor cells (NPCs). We present a novel technique to limit the radiation dose to @entity11408 without compromising @entity5 coverage. A study was performed in @entity19 to examine the rationale and another was conducted in @entity1 to determine its feasibility. C57BL/6 @entity19 received localized radiation using a dedicated animal irradiation system with on-board CT imaging with either: (1) Radiation which spared @entity11408 containing regions; (2) Radiation which did not spare these niches; or (3) Sham irradiation. @entity19 were sacrificed 24  h later and the brains were processed for immunohistochemical Ki-67 staining. For the @entity1 component of the study, 33 @entity1 with primary @entity1313 were evaluated. Two intensity modulated radiotherapy (IMRT) plans were retrospectively compared: a standard clinical plan and a plan which spares @entity11408 regions while maintaining the same dose coverage of the @entity5 . The change in radiation dose to the contralateral @entity11408 -containing regions was recorded. In the @entity19 model, non- @entity11408 -sparing radiation treatment resulted in a significant decrease in the number of Ki67(+) cells in dentate gyrus (DG) (P  =  0.008) and subventricular zone (SVZ) (P  =  0.005) compared to @entity11408 -sparing radiation treatment. In @entity11408 -sparing clinical plans, @entity11408 regions received significantly lower radiation dose with no clinically relevant changes in @entity5 coverage. This novel radiation technique should significantly reduce radiation doses to @entity11408 containing regions of the brain which may reduce @entity149 following @entity1161 for @entity1313 .

title: A radiotherapy technique to limit dose to neural progenitor cell niches without compromising XXXX coverage.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['neurocognitive toxicity']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['RT', 'Radiation therapy']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive deficits']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: PURPOSE: The fixation and incorporation of @entity397 rotator cuff tendon to bone is a major concern in rotator cuff repair surgery. Rotator cuff repair usually fails at the tendon-bone interface, especially in case of large or massive tears. To enhance @entity79 , an injectable hydrogel made with periosteal progenitor cells(PPCs) and @entity7028 ( @entity7028 ) tethered with bone morphogenic protein-2( @entity9040 ) was developed to encourage extracellular matrix synthesis for tendon-to-bone healing in rotator cuff repair. METHODS: The infraspinatus tendon was cut from the greater tuberosity and repaired through a transosseous tunnel with the injectable progenitor cell- @entity9040 hydrogel applied between the tendon-bone interface. The injectable hydrogel was prepared from 10% @entity7028 ( @entity7028 ) containing 0.05% of the photoinitiator. @entity9040 tethered with @entity968 ( @entity970 ) was blended to the hydrogel. @entity95 periosteal progenitor cells (PPCs) isolated from periosteum were mixed with hydrogel and injected on the tendon-bone interface. Ultraviolet radiation (365  nm) was applied for 60  s to photopolymerize the injection and solidify the hydrogel. The @entity95 were killed at 4 and 8  weeks. The morphological characteristics of the healing tendon-to-bone interface were evaluated by histological and immunohistochemical methods. The biomechanical test was done to determine healing attachment strength. RESULTS: At both the 4- and 8-week killing, histological analysis of the tendon-bone interface showed an increasing fibrocartilage and bone layer formed in the tendon-bone interface in @entity7028 group. At 4  weeks, fibrocartilage-like tissue was observed in a focal area. At 8  weeks, further matrix deposition occurred with fibrocartilage formation in the @entity79 , and bone formation appeared near host bone. Immunohistochemistry revealed the presence of aggrecan and type II collagen. Biomechanical testing revealed a higher maximum pull-out load at all time points with a statistically significant difference at 4 and 8  weeks postoperatively. CONCLUSION: @entity7028 hydrogel was approved as an adequate matrix for the encapsulation of cells and signal factor, and as an effective local delivery method to the tendon-bone interface through injection and photopolymerization. The PPCs- @entity9040 -hydrogel provides a powerful inductive ability between the tendon and the bone and enhances @entity79 through the neoformation of fibrocartilage.

title: Enhancement of rotator cuff @entity79 with injectable periosteum progenitor cells- XXXX hydrogel in vivo.

entities_list: @entity7028 :: ('MESH:C437167', 'Chemical') :: ['PEGDA', 'poly (ethylene glycol) diacrylate']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'Rabbit']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['tendon-bone healing', 'tendon-bone junction']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptured']

entities_list: @entity968 :: ('MESH:D011092', 'Chemical') :: ['poly(ethylene glycol)']

answer: @entity9040 :: (100009349(Tax:9986),Gene) :: ['BMP-2']


abstract: PURPOSE: The fixation and incorporation of @entity397 rotator cuff tendon to bone is a major concern in rotator cuff repair surgery. Rotator cuff repair usually fails at the tendon-bone interface, especially in case of large or massive tears. To enhance @entity79 , an injectable hydrogel made with periosteal progenitor cells(PPCs) and @entity7028 ( @entity7028 ) tethered with bone morphogenic protein-2( @entity9040 ) was developed to encourage extracellular matrix synthesis for tendon-to-bone healing in rotator cuff repair. METHODS: The infraspinatus tendon was cut from the greater tuberosity and repaired through a transosseous tunnel with the injectable progenitor cell- @entity9040 hydrogel applied between the tendon-bone interface. The injectable hydrogel was prepared from 10% @entity7028 ( @entity7028 ) containing 0.05% of the photoinitiator. @entity9040 tethered with @entity968 ( @entity970 ) was blended to the hydrogel. @entity95 periosteal progenitor cells (PPCs) isolated from periosteum were mixed with hydrogel and injected on the tendon-bone interface. Ultraviolet radiation (365  nm) was applied for 60  s to photopolymerize the injection and solidify the hydrogel. The @entity95 were killed at 4 and 8  weeks. The morphological characteristics of the healing tendon-to-bone interface were evaluated by histological and immunohistochemical methods. The biomechanical test was done to determine healing attachment strength. RESULTS: At both the 4- and 8-week killing, histological analysis of the tendon-bone interface showed an increasing fibrocartilage and bone layer formed in the tendon-bone interface in @entity7028 group. At 4  weeks, fibrocartilage-like tissue was observed in a focal area. At 8  weeks, further matrix deposition occurred with fibrocartilage formation in the @entity79 , and bone formation appeared near host bone. Immunohistochemistry revealed the presence of aggrecan and type II collagen. Biomechanical testing revealed a higher maximum pull-out load at all time points with a statistically significant difference at 4 and 8  weeks postoperatively. CONCLUSION: @entity7028 hydrogel was approved as an adequate matrix for the encapsulation of cells and signal factor, and as an effective local delivery method to the tendon-bone interface through injection and photopolymerization. The PPCs- @entity9040 -hydrogel provides a powerful inductive ability between the tendon and the bone and enhances @entity79 through the neoformation of fibrocartilage.

title: Enhancement of rotator cuff XXXX with injectable periosteum progenitor cells- @entity9040 hydrogel in vivo.

answer: @entity79 :: (MESH:D001847,Disease) :: ['tendon-bone healing']


abstract: Ambulatory monitoring of the electrocardiogram was performed in 131 healthy @entity1 aged between 10 and 13 years for two consecutive periods of 24 hours. When awake the maximal heart rates ranged from 100 to 200 and the minimal from 45 to 80 beats per minute. During sleep maximal rates were 60 to 110 beats and minimal rates 30 to 70 beats per minute. @entity13610 was seen in every @entity1 and in 36 (27.5%) no other changes were found. @entity616 , Mobitz type I, was not seen. @entity616 , Mobitz @entity1605 , occurred twice only. Complete @entity616 occurred in 8.4 per cent, never lasted more than one cycle, and was always followed by a junctional beat. First degree @entity713 occurred in 8.4 per cent and Mobitz type I @entity713 in 10.7 per cent. Premature beats were always single, atrial in 13 per cent, ventricular in 26 per cent, and except in two @entity1 were never more than four in 24 hours. There were no episodes of @entity1165 . Changes in P wave morphology were common and slow junctional rhythm occurred in 13 per cent during sleep.

title: Results of 24 hour ambulatory monitoring of electrocardiogram in 131 healthy XXXX aged 10 to 13 years.

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular or supraventricular tachycardia']

entities_list: @entity713 :: ('MESH:D054537', 'Disease') :: ['atrioventricular block']

entities_list: @entity13610 :: ('MESH:D001146', 'Disease') :: ['Sinus arrhythmia']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['Sinuatrial block', 'sinuatrial block']

answer: @entity1 :: (9606,Species) :: ['boys']


abstract: Two-dimensional echocardiography at rest was used to analyze segmental wall motion abnormalities for detecting @entity453 in @entity1 with and without a history of @entity583 . One hundred twenty-five echocardiograms were analyzed in a randomized, blinded fashion. They were obtained from 55 consecutive @entity1 found to have significant @entity453 at angiography, 59 consecutive normal subjects and 11 @entity1 with @entity384 . The overall sensitivity of two-dimensional echocardiography was relatively low at 67%. However, specificity was 99%. The sensitivity was higher in @entity1 with past @entity583 than in those without @entity583 (81 versus 42%), as expected. Echocardiography can detect segmental wall motion abnormalities in some @entity1 with @entity453 and no overt prior @entity583 . This was highlighted by nine such @entity1 with @entity453 and no prior @entity583 or electrocardiographic Q waves who were found to have segmental wall motion abnormalities. A semiquantitative, two-dimensional echocardiographic segmental wall motion score was derived for 47 @entity1 and was correlated with angiographic left ventricular ejection fraction (r = 0.71). This score differentiated @entity1 with a normal ejection fraction (greater than 50%) from those with a depressed ejection fraction (less than 50%): 1.1 +/- 1.6 versus 6.9 +/- 3.1 (p less than 0.001). Almost all @entity1 (92%) with an echocardiographic score of five or more had an abnormal ejection fraction of less than 50%. In @entity1 with chronic @entity712 , the echocardiogram separated those with @entity384 from those with @entity453 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: Value of two-dimensional echocardiography in evaluating XXXX : a randomized blinded analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: In the therapy of primary @entity43 in which the @entity5 is located in one ovary, radical operation including the uterus and contralateral ovary is performed in principle even in the case of young @entity1 . However, there have been only a few results reported on the primary cases in our country, and the radical operation is adopted at present in line with western policy. In the present study, the authors examined mainly the prognosis of 49 @entity1 with primary @entity43 (stage Ia, 25 cases; stage Ib, 2 cases; stage Ic, 22 cases), and the following results were obtained. Among 25 cases at stage Ia, the radical operation was performed on 14 cases, and only the conservative operation was performed on the remaining 11 cases. All of the latter are still well. Only one died among @entity1 at stage Ia. Therefore, in these cases, complete treatments were done, including radical operation, postoperative irradiation and chemotherapy, and second look operation. The prognosis of the @entity1 at Ic was worse than that at IIa + b. Therefore, it was felt to be necessary to treat them as progressive @entity5 . There was no difference between the prognoses of the conservative and radical operations even at stage Ic. Thus, problems such as functional maintenance were thought to be taken into consideration. Risk factors considered were tissue type, amount of @entity843 , capsular rhexis, and advanced age, etc. Since the prognosis after the second look operation was good, it was considered to be a treatment which should be introduced actively, even at stage I.

title: [Assessment of cases with XXXX stage I].

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: Two closely related adenovirus early region 1A proteins are expressed in transformed cells. The smaller of these, which is 243 @entity1522 in length, is required for the transformation of primary @entity35 cells and for the transformation of immortalized @entity35 cells to anchorage-independent growth. This protein is not required for productive infection of exponentially growing HeLa cells but is required for maximal replication in growth (G0)-arrested @entity1 lung fibroblasts ( @entity1 cells). To determine the function of this protein in viral replication in these G0-arrested cells, we compared viral early mRNA, early protein, and late protein synthesis after infection with wild type or a mutant which does not express the protein. No differences were found. However, viral DNA synthesis by the mutant was delayed and decreased to 20 to 30% that of wild type in these cells. Viral DNA synthesis was much less defective in growing @entity1 cells, and in the transformed @entity1 HeLa cell line it occurred at wild-type levels. Furthermore, the mutant which can express only the 243- @entity535 early region 1A protein induced cellular DNA synthesis in G0-arrested @entity35 cells to the same level as wild-type virus. A mutant which can express only the 289- @entity535 early region 1A protein induced less cellular DNA synthesis in G0-arrested @entity35 cells. We propose that the early region 1A 243- @entity535 protein alters the physiology of arrested permissive cells to allow maximal viral DNA replication. In nonpermissive rodent cells, the 243- @entity535 protein drives G0-arrested cells into S phase. This activity is probably important for the immortalization of primary cells.

title: An adenovirus early region 1A protein is required for maximal viral DNA replication in growth-arrested XXXX cells.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino-acid']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The surgical experience with @entity1700 ( @entity1700 ) at the Venderbilt Hospital between the years 1969 and 1979 was reviewed. Twenty-five @entity1 with @entity1700 were studied. All but one @entity1 presented at less than 1 year of age, and 11 @entity1 were operated upon in the first 2 weeks of life. Operative mortality rate was 20% (5/25). Four of the five deaths were in critically ill neonates requiring preoperative ventilatory support. All operative deaths were in @entity1 with @entity3885 . All operative survivors have been followed for a mean 4.5 years (6 months to 10 years). There have been no late deaths or cases of symptomatic @entity3885 . All @entity1 have had normal growth patterns. Ten @entity1 have been recatheterized. Pulmonary artery systolic pressure, which was markedly elevated prior to operation, fell to normal levels after operation. Ventricular function has been evaluated by quantitative angiocardiography in nine @entity1 before and after operation. Left ventricular size and function were markedly depressed preoperatively and rose to normal levels in postoperative survivors. Left atrial maximal volume was found to be 94% of normal values. These data support the contention that preoperative @entity3885 is the single risk factor predicting higher risk of @entity204 . The presence of severe @entity308 of left ventricular size and function preoperatively does not predict a higher operative risk, and postoperative survivors can expect normal ventricular function.

title: XXXX in infancy. Ten years' experience including studies of postoperative ventricular function.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity1700 :: ('MESH:D012587', 'Disease') :: ['total anomalous pulmonary venous connection', 'TAPVC']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['pulmonary venous obstruction']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['operative death']

answer: @entity1700 :: (MESH:D012587,Disease) :: ['Total anomalous pulmonary venous connection']


abstract: BACKGROUND: @entity17834 foam (BVF) is a new topical corticosteroid formulation. In @entity11885 @entity1 BVF has induced a significantly greater clinical improvement in comparison with corticosteroid lotions. No data are available to date regarding the efficacy and safety of BVF in mild-to-moderate @entity1663 ( @entity1663 ). STUDY AIM: To evaluate the efficacy, tolerability and safety of BVF treatment in @entity1 with mild-to-moderate @entity1663 . SUBJECTS AND METHODS: Sixty-one @entity1 (26 @entity1 and 35 @entity1 ; mean age 41 +/- 13 years) with mild-to-moderate @entity1663 (hair loss < 26%) were enrolled in a parallel-group, investigator-blinded trial. Subjects were assigned randomly to BVF (31 @entity1 ) or to @entity9090 lotion (BDL) (30 subjects). Both treatments were applied to the affected areas twice a day for 12 consecutive weeks. OUTCOMES: The primary study outcome was to compare the hair regrowth rate. Efficacy was evaluated at weeks 8 and 12 and at follow up (week 20), using a hair regrowth score (RGS) with a scale ranging from 0 (regrowth < 10%) to 4 (regrowth > 75%). RESULTS: Fifty-seven subjects (93%) completed the trial. At week 20, the RGS was 3.1 +/- 1.5 and 1.8 +/- 1.6 in the BVF and BDL groups, respectively (P < 0.01). A RGS > 3 was observed in 61% of @entity1 in the BVF group (19/31) in comparison with 27% (8/30) in the BDL group (P < 0.03). No serious adverse events were observed in both groups during the study. CONCLUSION: @entity17834 foam has shown to be an effective and well-tolerated treatment of mild-to-moderate @entity1663 . Further trials are warranted to evaluate the role of this new formulation in comparison or in combination with intralesional corticosterioids in @entity1663 treatment.

title: Efficacy of XXXX foam formulation in comparison with @entity9090 lotion in the treatment of mild-to-moderate @entity1663 : a multicenter, prospective, randomized, controlled, investigator-blinded trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity17834 :: ('CHEBI:31277', 'Chemical') :: ['Betamethasone valerate']

entities_list: @entity9090 :: ('MESH:C011175', 'Chemical') :: ['betamethasone dipropionate']

entities_list: @entity1663 :: ('MESH:D000506', 'Disease') :: ['AA', 'alopecia areata']

entities_list: @entity11885 :: ('MESH:C538225', 'Disease') :: ['scalp psoriasis']

answer: @entity17834 :: (CHEBI:31277,Chemical) :: ['betamethasone valerate']


abstract: BACKGROUND: @entity17834 foam (BVF) is a new topical corticosteroid formulation. In @entity11885 @entity1 BVF has induced a significantly greater clinical improvement in comparison with corticosteroid lotions. No data are available to date regarding the efficacy and safety of BVF in mild-to-moderate @entity1663 ( @entity1663 ). STUDY AIM: To evaluate the efficacy, tolerability and safety of BVF treatment in @entity1 with mild-to-moderate @entity1663 . SUBJECTS AND METHODS: Sixty-one @entity1 (26 @entity1 and 35 @entity1 ; mean age 41 +/- 13 years) with mild-to-moderate @entity1663 (hair loss < 26%) were enrolled in a parallel-group, investigator-blinded trial. Subjects were assigned randomly to BVF (31 @entity1 ) or to @entity9090 lotion (BDL) (30 subjects). Both treatments were applied to the affected areas twice a day for 12 consecutive weeks. OUTCOMES: The primary study outcome was to compare the hair regrowth rate. Efficacy was evaluated at weeks 8 and 12 and at follow up (week 20), using a hair regrowth score (RGS) with a scale ranging from 0 (regrowth < 10%) to 4 (regrowth > 75%). RESULTS: Fifty-seven subjects (93%) completed the trial. At week 20, the RGS was 3.1 +/- 1.5 and 1.8 +/- 1.6 in the BVF and BDL groups, respectively (P < 0.01). A RGS > 3 was observed in 61% of @entity1 in the BVF group (19/31) in comparison with 27% (8/30) in the BDL group (P < 0.03). No serious adverse events were observed in both groups during the study. CONCLUSION: @entity17834 foam has shown to be an effective and well-tolerated treatment of mild-to-moderate @entity1663 . Further trials are warranted to evaluate the role of this new formulation in comparison or in combination with intralesional corticosterioids in @entity1663 treatment.

title: Efficacy of @entity17834 foam formulation in comparison with XXXX lotion in the treatment of mild-to-moderate @entity1663 : a multicenter, prospective, randomized, controlled, investigator-blinded trial.

answer: @entity9090 :: (MESH:C011175,Chemical) :: ['betamethasone dipropionate']


abstract: BACKGROUND: @entity17834 foam (BVF) is a new topical corticosteroid formulation. In @entity11885 @entity1 BVF has induced a significantly greater clinical improvement in comparison with corticosteroid lotions. No data are available to date regarding the efficacy and safety of BVF in mild-to-moderate @entity1663 ( @entity1663 ). STUDY AIM: To evaluate the efficacy, tolerability and safety of BVF treatment in @entity1 with mild-to-moderate @entity1663 . SUBJECTS AND METHODS: Sixty-one @entity1 (26 @entity1 and 35 @entity1 ; mean age 41 +/- 13 years) with mild-to-moderate @entity1663 (hair loss < 26%) were enrolled in a parallel-group, investigator-blinded trial. Subjects were assigned randomly to BVF (31 @entity1 ) or to @entity9090 lotion (BDL) (30 subjects). Both treatments were applied to the affected areas twice a day for 12 consecutive weeks. OUTCOMES: The primary study outcome was to compare the hair regrowth rate. Efficacy was evaluated at weeks 8 and 12 and at follow up (week 20), using a hair regrowth score (RGS) with a scale ranging from 0 (regrowth < 10%) to 4 (regrowth > 75%). RESULTS: Fifty-seven subjects (93%) completed the trial. At week 20, the RGS was 3.1 +/- 1.5 and 1.8 +/- 1.6 in the BVF and BDL groups, respectively (P < 0.01). A RGS > 3 was observed in 61% of @entity1 in the BVF group (19/31) in comparison with 27% (8/30) in the BDL group (P < 0.03). No serious adverse events were observed in both groups during the study. CONCLUSION: @entity17834 foam has shown to be an effective and well-tolerated treatment of mild-to-moderate @entity1663 . Further trials are warranted to evaluate the role of this new formulation in comparison or in combination with intralesional corticosterioids in @entity1663 treatment.

title: Efficacy of @entity17834 foam formulation in comparison with @entity9090 lotion in the treatment of mild-to-moderate XXXX : a multicenter, prospective, randomized, controlled, investigator-blinded trial.

answer: @entity1663 :: (MESH:D000506,Disease) :: ['alopecia areata']


abstract: In a prospective study of morbid @entity28 at the University of Florida, 225 consecutive @entity1 with medical complication of @entity28 underwent intestinal bypass during a ten-year period from 1967 to 1977. The average age was 35 years, with the average weight being 322 lb (145 kg). Oral cholecystograms were obtained preoperatively in all @entity1 , and repeated at one and five years postoperatively. If a @entity1 developed symptoms, ultrasonography or a cholecystogram was performed at that time. The cumulative preoperative prevalence of @entity2963 was 30.7 percent. The 156 @entity1 with an intact gallbladder made up the study group. These @entity1 have been followed for an average of 36 months, and 16 have subsequently demonstrated @entity2963 . The post intestinal bypass incidence of @entity2963 from surgery to the time of their last oral cholecystogram was 7.2 percent per year. Analysis of variance demonstrated no significant differences between @entity1 , with and without @entity2963 , with respect to serum @entity1674 , @entity165 , or percent @entity353 . The incidence of @entity2963 in the morbidly @entity28 increases further with the metabolic derangements induced by jejunoileal bypass. The increased incidence of @entity2963 after intestinal bypass, along with the other serious metabolic sequelae that follow this procedure, suggests that the continued long-term followup of these @entity1 is mandatory.

title: The incidence of XXXX after jejunoileal bypass.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity2963 :: (MESH:D002769,Disease) :: ['cholelithiasis']


abstract: BACKGROUND: We evaluated the accuracy of @entity1600 ( @entity1600 ) in @entity1 with @entity0 who had received preoperative therapy. METHODS: A prospective clinical trial evaluated 122 @entity1 who had @entity1600 followed by axillary lymph node dissection. Thirty-two @entity1 had @entity0 and received preoperative @entity632 -based chemotherapy or @entity1311 and radiotherapy. RESULTS: A @entity1600 ( @entity1600 ) was identified in 31 (97%) of 32 @entity1 . The @entity1600 predicted the status of the axillary nodes in 30 (97%) of 31 @entity1 . Eighteen (58%) of 31 had @entity3 in the @entity1600 . Eighteen of 19 @entity1 with axillary @entity3 had a @entity5 (sensitivity, 95%; false-negative rate, 5%). Eight (44%) of 18 @entity1 with @entity3 in the @entity1600 also had @entity3 in 1 or more nonsentinel nodes. CONCLUSIONS: In this relatively small study, the accuracy of @entity1600 in @entity1 with @entity0 treated with preoperative therapy was similar to that achieved in @entity0 . If these results are confirmed in a larger cohort, it may be feasible to substitute @entity1600 for routine axillary lymph node dissection in this population. This approach could reduce the morbidity of surgical therapy while preserving the accuracy of axillary staging and maintaining regional control in this high-risk population.

title: Lymphatic mapping and sentinel lymphadenectomy after preoperative therapy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['early-stage breast cancer', 'stage II and III breast cancer', 'stage II or III breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor-positive SLN']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['SLND', 'sentinel lymph node dissection', 'sentinel lymph node', 'SLN']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity0 :: (MESH:D001943,Disease) :: ['stage II and III breast cancer']