abstract: Abstract The purpose of this study was to evaluate the presence of extracapsular invasion (ECI) in positive sentinel lymph nodes (SLNs) as a predictor of disease recurrence in @entity0 . @entity4298 biopsy was performed on 318 breasts of 316 @entity0 @entity1 , of which 50 (15.7%) had positive SLNs. Six (12.0%) of these 50 cases had disease recurrence. The clinicopathologic features of these cases were reviewed. The ECI at SLNs was not significantly associated with disease recurrence. The recurrence-free interval by Kaplan-Meier curves did not differ significantly among @entity1 with and without ECI at SLNs. On the other hand, metastasis at non-SLNs was observed in 12 cases (24.0%) among the 50 cases with positive SLNs, and in the non- @entity4298 metastasis group there were 7 @entity1 with ECI at non-SLNs. Three of 7 cases with ECI at non-SLNs had disease recurrence and none of those 5 without ECI at non-SLNs had disease recurrence. Our current study suggests that the presence of ECI at metastatic SLNs is not associated with recurrent disease in @entity0 . Our results also imply that @entity1 with ECI at positive non-SLNs have a high risk of disease recurrence.

title: Extracapsular invasion of sentinel lymph nodes is not associated with disease recurrence in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: Previous studies have reported a meal-induced rise in hepatic glycogen stores from baseline levels following a fast and it is generally assumed that glycogen levels rise steadily following meals throughout the day. However, measurements are normally taken in conditions that are not typical of the Western breakfast, which is relatively @entity1735 rich with a lower calorific content than most experimental test meals. As such, little is known about the normal metabolic response to a realistic, low calorie morning meal. Therefore, the aim of this pilot study was to evaluate the effects of a low dose oral @entity413 intake on hepatic glycogen levels following an overnight fast in healthy subjects. Glycogen levels were monitored in vivo using @entity7352 Magnetic Resonance Spectroscopy at baseline and hourly for 4 hours following either a 50 g @entity413 drink (773 kJ) or a control drink (0 kJ) given over two different visits. During the control visit hepatic glycogen levels decreased throughout the experiment with statistically significant decreases from baseline at 190 minutes (P < 0.05) and 250 minutes (P < 0.05). By contrast, the low dose @entity413 intake maintained glycogen concentrations with no significant decrease from baseline over 4 hours. A comparison between visits revealed that mean glycogen concentrations were significantly greater during the @entity413 visit (control visit, AUC = 218    39 mol L(-1) min(-1); @entity413 visit, AUC = 305    49 mol L(-1) min(-1); P < 0.05). Liver volume decreased significantly from baseline at 180 minutes (P < 0.05) post consumption in both groups, with no significant difference found between visits. Gastric content volumes were significantly higher for the @entity413 visit immediately following consumption (P < 0.001) and at 60 minutes (P = 0.007) indicating slower gastric emptying for the @entity413 compared with the control. In conclusion, following an overnight fast, a low dose oral @entity413 challenge prevents a reduction in hepatic glycogen content but does not increase it above fasted levels.

title: A low calorie morning meal prevents the decline of hepatic glycogen stores: a pilot in vivo XXXX magnetic resonance study.

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

answer: @entity7352 :: (CHEBI:36928,Chemical) :: ['(13)C']


abstract: INTRODUCTION: The prevalence of congenital @entity1498 is 4 in 10 000 live birth. @entity1498 is typically located in the aortic isthmus, but it may occur at atypical sites. Treatment options include both surgical and endovascular interventions. In @entity1 undergoing surgical or endovascular intervention late complications such as recoarctation or aortic @entity439 may develop. AIM: The aim of the authors was to analyse their own experience in late complication and treatment options of @entity1498 operated in childhood. METHOD: Retrospective analysis of data of 32 @entity1 treated between 1980 and 2014 for late complications 8-42 years after surgical treatment of @entity1498 . RESULTS: In 28 @entity1 @entity439 formation after isthmic patch plasty was found. Two @entity1 had aortobronchial fistula, 2 @entity1 showed @entity254 disruption and 2 @entity1 had graft stenosis. During operation hybrid solution was performed in 23 @entity1 , isthmic aorto-aortic inlay graft interposition in 5 @entity1 , aorto-aortic bypass in 2 @entity1 , subclavio-aortic bypass in 2 @entity1 , graft patch plasty in one @entity1 and ilio-renal bypass in one @entity1 . Complications included severe @entity954 in one @entity1 and pneumothorax in one @entity1 . No early or late mortality occurred. CONCLUSIONS: The authors conclude that life long control is mandatory in order to detect late complications in @entity1 who underwent operation of @entity1498 in childhood.

title: [Late complications and treatment options of XXXX operated in childhood].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity1498 :: ('MESH:D001017', 'Disease') :: ['aortic coarctation', 'Aortic coarctation']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['intraoperative bleeding']

answer: @entity1498 :: (MESH:D001017,Disease) :: ['aortic coarctation']


abstract: OBJECTIVE: The @entity209 , (MetS) a global epidemic, is a state of low grade chronic @entity32 and confers an increased risk for @entity6 and CVD. We have previously reported increased activity of the pathogen recognition receptors, Toll-like receptors (TLRs), @entity2938 and @entity2939 in MetS. We hypothesized that increased TLR activity in MetS is due in part to increased levels of circulating PAMP-binding proteins, soluble @entity5750 (sCD14), @entity5752 ( @entity5752 ) and the damage associated molecular pattern (DAMP), @entity518 ( @entity518 ). METHODS: We measured sCD14, @entity5752 and @entity518 in fasting plasma from nascent MetS (n  =  37) and healthy control subjects (n  =  32) by ELISA. We also investigated the effects of sCD14 and @entity5752 on @entity2939 activity in @entity1 aortic endothelial cells (HAECs). RESULTS: Following adjustment for body mass index and waist circumference, sCD14, @entity5752 and @entity518 levels remained significantly increased in MetS. Also their levels increased with increasing numbers of MetS risk factors. Only sCD14 correlated significantly with monocyte @entity2939 protein and activity. None of these soluble biomarkers correlated with @entity2938 protein. Both sCD14 and @entity518 correlated significantly with HOMA-IR. In @entity558 primed HAECs, sCD14 compared to @entity5752 , resulted in a greater increase in both @entity2939 abundance and inflammatory biomediators (NF-kB, @entity1356 , @entity687 and @entity310 ). CONCLUSION: Thus, we make the novel observation that sCD14 reflects increased monocyte @entity2939 protein and activity in nascent MetS and by contributing to @entity32 could explain, in part, the increased risk for @entity6 and CVD.

title: Circulating pathogen associated molecular pattern - binding proteins and XXXX in nascent @entity209 : implications for cellular Toll-like receptor activity.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'increased cellular inflammation']

entities_list: @entity5752 :: ('3929', 'Gene') :: ['lipopolysaccharide binding protein', 'LBP']

entities_list: @entity518 :: ('3146', 'Gene') :: ['High Mobility Group Box protein 1', 'HMGB-1']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic Syndrome']

answer: @entity518 :: (3146,Gene) :: ['High Mobility Group Box protein 1']


abstract: OBJECTIVE: The @entity209 , (MetS) a global epidemic, is a state of low grade chronic @entity32 and confers an increased risk for @entity6 and CVD. We have previously reported increased activity of the pathogen recognition receptors, Toll-like receptors (TLRs), @entity2938 and @entity2939 in MetS. We hypothesized that increased TLR activity in MetS is due in part to increased levels of circulating PAMP-binding proteins, soluble @entity5750 (sCD14), @entity5752 ( @entity5752 ) and the damage associated molecular pattern (DAMP), @entity518 ( @entity518 ). METHODS: We measured sCD14, @entity5752 and @entity518 in fasting plasma from nascent MetS (n  =  37) and healthy control subjects (n  =  32) by ELISA. We also investigated the effects of sCD14 and @entity5752 on @entity2939 activity in @entity1 aortic endothelial cells (HAECs). RESULTS: Following adjustment for body mass index and waist circumference, sCD14, @entity5752 and @entity518 levels remained significantly increased in MetS. Also their levels increased with increasing numbers of MetS risk factors. Only sCD14 correlated significantly with monocyte @entity2939 protein and activity. None of these soluble biomarkers correlated with @entity2938 protein. Both sCD14 and @entity518 correlated significantly with HOMA-IR. In @entity558 primed HAECs, sCD14 compared to @entity5752 , resulted in a greater increase in both @entity2939 abundance and inflammatory biomediators (NF-kB, @entity1356 , @entity687 and @entity310 ). CONCLUSION: Thus, we make the novel observation that sCD14 reflects increased monocyte @entity2939 protein and activity in nascent MetS and by contributing to @entity32 could explain, in part, the increased risk for @entity6 and CVD.

title: Circulating pathogen associated molecular pattern - binding proteins and @entity518 in nascent XXXX : implications for cellular Toll-like receptor activity.

answer: @entity209 :: (MESH:D008659,Disease) :: ['metabolic syndrome']


abstract: OBJECTIVE: The Scales for Outcomes in @entity191 (SCOPA-AUT) questionnaire was used to assess @entity5433 in @entity1 with @entity16 . The aim of this study was to evaluate the reliability of the Japanese version of the SCOPA-AUT. METHODS: We translated the SCOPA-AUT from English to Japanese. Thirty-one @entity1 with diseases involving autonomic symptoms completed the form twice. The reliability was assessed by Cronbach's coefficient alphas and intraclass correlation coefficients (ICCs). RESULTS: The average (standard deviation, SD) total scores of the first and second assessments of the SCOPA-AUT were 15.7 (SD, 7.1) and 13.6 (SD, 6.5), respectively. The Cronbach's coefficient alphas were globally high, but the ICCs were moderately high. The valid response rates for the questions about @entity250 were 36.7% in @entity1 and 26.6% in @entity1 . CONCLUSIONS: The Japanese version of the SCOPA-AUT had high internal consistency. However, the questions about @entity250 showed less valid response rates.

title: Reliability of the Japanese version of the scales for outcomes in XXXX questionnaire.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's Disease-Autonomic"]

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease-autonomic']


abstract: OBJECTIVE: To evaluate resource use and outcomes of @entity884 in @entity1 with and without preexisting @entity299 via a national cohort. STUDY DESIGN: @entity1 <19 years of age hospitalized from 2004 to 2010 with @entity884 at 37 centers in the Pediatric Health Information Systems database were included. We excluded @entity1 primarily hospitalized for chronic medical conditions. We used regression analysis to evaluate factors associated with poor outcomes (defined as mortality, mechanical cardiac support, or @entity64 ). RESULTS: There were 1033 cases of @entity884 , of which 663 had @entity299 and 370 did not. Compared with the group without @entity299 , @entity884 in the cohort with @entity299 occurred at younger age, was more commonly attributable to streptococcus, was more likely to require cardiac surgery for @entity884 , and was associated with a lower risk of @entity64 . Mortality was 6.7% (n = 45) and 3.5% (n = 13) in groups with and without @entity299 , respectively. Factors associated with poor outcome in the cohort with @entity299 included greater risk of mortality score ( @entity45060 ), mechanical ventilation (OR 3.1), use of antiarrhythmics (OR 2.7), and use of vasoactive medications ( @entity27893 ). In the cohort without @entity299 , factors associated with poor outcome included @entity177 (OR 19.3), greater risk of mortality score (OR 4.2), use of antiarrhythmics ( @entity27893 ), and mechanical ventilation (OR 2.2). Median charge of hospitalization was  131,893 in the group without @entity299 and  140,655 in the group with @entity299 . CONCLUSION: @entity884 remains a significant cause of morbidity, mortality, and resource use particularly in @entity1 with @entity299 .

title: Resource utilization and outcomes of XXXX in @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['Infective endocarditis', 'infective endocarditis']

answer: @entity884 :: (MESH:D004696,Disease) :: ['infective endocarditis']


abstract: OBJECTIVE: To evaluate resource use and outcomes of @entity884 in @entity1 with and without preexisting @entity299 via a national cohort. STUDY DESIGN: @entity1 <19 years of age hospitalized from 2004 to 2010 with @entity884 at 37 centers in the Pediatric Health Information Systems database were included. We excluded @entity1 primarily hospitalized for chronic medical conditions. We used regression analysis to evaluate factors associated with poor outcomes (defined as mortality, mechanical cardiac support, or @entity64 ). RESULTS: There were 1033 cases of @entity884 , of which 663 had @entity299 and 370 did not. Compared with the group without @entity299 , @entity884 in the cohort with @entity299 occurred at younger age, was more commonly attributable to streptococcus, was more likely to require cardiac surgery for @entity884 , and was associated with a lower risk of @entity64 . Mortality was 6.7% (n = 45) and 3.5% (n = 13) in groups with and without @entity299 , respectively. Factors associated with poor outcome in the cohort with @entity299 included greater risk of mortality score ( @entity45060 ), mechanical ventilation (OR 3.1), use of antiarrhythmics (OR 2.7), and use of vasoactive medications ( @entity27893 ). In the cohort without @entity299 , factors associated with poor outcome included @entity177 (OR 19.3), greater risk of mortality score (OR 4.2), use of antiarrhythmics ( @entity27893 ), and mechanical ventilation (OR 2.2). Median charge of hospitalization was  131,893 in the group without @entity299 and  140,655 in the group with @entity299 . CONCLUSION: @entity884 remains a significant cause of morbidity, mortality, and resource use particularly in @entity1 with @entity299 .

title: Resource utilization and outcomes of @entity884 in XXXX .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: PURPOSE: This study aimed to assess outcomes of liver transplantation (LTx) in @entity1 with @entity2876 ( @entity2876 ). METHODS: The Kasai procedure was performed for 358 @entity1 at Tohoku University Hospital between January 1955 and December 2013; 64 (17.9%) required LTx. These 64 @entity1 were divided into 4 groups according to their age at the time of transplantation: Group 1, aged <2 years (n = 27); Group 2, aged 2-9 years (n = 16); Group 3, aged 10-19 years (n = 11); and Group 4, aged >= 20 years (n = 10). Clinical parameters were evaluated retrospectively. RESULTS: Both living-donor (n = 57) and deceased-donor (n = 7) LTx were performed. Indications were irreversible @entity1087 (n = 53), intractable @entity255 (n = 3), @entity7185 (n = 6), portopulmonary @entity101 (n = 1), and intestinal @entity548 (n = 1). @entity1087 occurred more frequently in Groups 1 and 2 than in Groups 3 and 4 (p = 0.031). Survival rates were 81.5, 100, 90.9, and 80% in Groups 1, 2, 3, and 4, respectively. CONCLUSION: Although the overall LTx survival rate was satisfactory, some adult recipients experienced LTx-related difficulty. Close follow-up, meticulous assessment of physical and social conditions, presence of a multidisciplinary support system, and appropriate time course for LTx are all essential factors in the treatment of @entity2876 .

title: Liver transplantation following the Kasai procedure in treatment of XXXX : a single institution analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice', 'Jaundice']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity7185 :: ('MESH:D020065', 'Disease') :: ['hepatopulmonary syndrome']

entities_list: @entity2876 :: ('MESH:D001656', 'Disease') :: ['BA', 'biliary atresia']

entities_list: @entity255 :: ('MESH:D002761', 'Disease') :: ['cholangitis']

answer: @entity2876 :: (MESH:D001656,Disease) :: ['biliary atresia']


abstract: The radioallergosorbent test (RAST) has been used for in vitro diagnosis of @entity566 in a selected group of @entity1 with @entity565 and @entity56 . The results were compared with those of provocation tests and also with the results of skin tests. Where the results of RAST and the provocation tests differed, repeated tests were performed, initially in vitro and secondly in vivo. Selected commercial allergens of good quality were used and, for the most part, the same allergen batches were used in RAST, in the provocation tests and in the skin tests. A 76% correlation between RAST and provocation tests was found on preliminary investigation before divergent results were repeated. This degree of correlation is similar to that obtained previously in unselected @entity1 using RAST as a part of the routine diagnostic. On repeated examination, agreement was obtained in an additional 16% of the cases. The major part of the improvement (13%) was due to conversion of preliminary RAST results from negative to positive in @entity1 with positive provocation tests. To a minor extent, the improvement was due to the fact that in, some @entity1 with positive RAST, negative provocation tests became positive when repeated. Finally, in one case an originally positive RAST in a @entity1 with a negative provocation test was found to be negative on re-examination. Comparing the final revised results of RAST and provocation tests there were no cases where a negative provocation test was combined with a positive RAST. Nearly all the @entity1 with positive provocation tests in spite of a negative RAST were shown to have low degree @entity566 . Although circulating reaginic antibodies are not always present, it seems that, on repeated investigations, the great majority of @entity1 with @entity565 and @entity2023 can be shown to have such antibodies even though the serum concentration may be low or very low. In doubtful cases repeated RAST examinations may be of value.

title: In vitro diagnosis of XXXX . V. The value of repeated testing using several batches of the allergen extract.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'child']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic rhinoconjunctivitis']

answer: @entity566 :: (MESH:D006967,Disease) :: ['atopic allergy']


abstract: Extracellular and bacterial factors that influence the phagocytosis and killing of staphylococci by @entity1 polymorphonuclear leukocytes have been studied. @entity5938 strains were, in general, more rapidly phagocytized than were @entity794 strains. However, two strains of @entity5938 had a very slow rate of ingestion. Although the rate of phagocytosis of @entity794 Wood 46 was greater than that of @entity794 502A, the Wood 46 strain was more difficult to kill. Serum was essential for phagocytosis of both @entity794 and @entity5938 . The opsonic titer of pooled serum was similar for @entity794 and @entity5938 . In normal pooled serum, heat-labile factors were more important for effective phagocytosis than they were in immune serum. Although a saturation point for ingestion was reached, the percentage of ingested bacteria that remained alive within the leukocyte remained relatively fixed. Heat-killed and live staphylococci were igested in a similar fashion. The rate of phagocytosis was greatly reduced at 41 degrees C.

title: Extracellular and bacterial factors influencing staphylococcal phagocytosis and killing by XXXX polymorphonuclear leukocytes.

entities_list: @entity5938 :: ('1282', 'Species') :: ['S. epidermidis', 'Staphylococcus epidermidis']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Mechanical @entity1545 was produced in 36 @entity468 with a fluid-percussion model in which @entity75 is produced by a single, brief, hydraulically-induced pressure transient that is conducted through the brain. Fluid-percussion injury induce elastic deformation of the brain resembling the @entity75 known to occur following head impact. Physiological responses and pahtological changes following injury were expressed as a function of peak pressure. Macroscopic central nervous system lesions concentrated at the pontomesencephalic junction, cervicomedullary junction, and in the cerebellar tonsils were consistently observed at and above 2.6 atmospheres (atm). At higher levels of injury (greater than or equal to 3.2 atm) there was extensive basal @entity510 . At very high levels of injury (greater than 4.0 atm) hemorrhagic contusions were noted at the cerebral hemisphere impact site. A spectrum of neuronal alterations was identified in the damaged areas. Computer analysis showed correlation of electroencephalographic (EEG) changes with the neuropathological changes, since EEG recovery became severely @entity73 .6 atm. No EEG changes were noted below 1.5 atm. From 1.5 to 2.2 atm there was a physiological response to injury but no significant changes were seen on neuropathological examination. This range of injury should permit further studies of the more subtle changes following mechanical @entity1545 without intraparenchymal @entity548 or @entity510 . The fluid-percussion model relates @entity75 following mechanical loading to a single pressure transient that is easily measured and controlled. Further quantitative investigation into the pathobiology of mechanical @entity1545 following graded @entity75 is thus made possible.

title: Fluid-percussion model of mechanical XXXX in the cat.

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain deformation', 'brain damage or dysfunction']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired above 2']

answer: @entity1545 :: (MESH:D020214,Disease) :: ['brain injury']


abstract: The belief that the smooth muscle contracting activity of angiotensin II (angiotensin) in the @entity840 ileum is partly mediated by release of @entity934 was reexamined, with the following results. 1. @entity3897 did not reduce the maximum contraction produced by angiotensin, although it caused a shift to the right of the log dose-response curve (dose ratio = 2.2). A similar shift was observed with @entity112 , @entity1812 and @entity12947 . 2. A moderate potentiation of angiotensin by @entity2607 was also observed, which was similarly found for the other agonists. 3. A previous report that @entity3897 blocks the fast (phasic) component of the isometric response of the ileum to angiotensin was not confirmed. The disappearance of the phasic component was found to be due to a tachyphylactic change in the response. 4. Depolarization by high doses of @entity1239 , and inhibition of @entity934 synthesis by @entity11348 , did not affect the response to angiotensin. 5. Ilei in which the intramural ganglia had been destroyed by incubation at 4 degrees 48-56 h responed maximally to angiotensin, without loss of the phasic component of the response. It is concluded that the available evidence does not support the participation of a cholinergic mechanism in the effect of angiotensin upon the @entity840 ileum.

title: Evidence against cholinergic mediation of the effect of angiotensin II on the XXXX ileum.

entities_list: @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine']

entities_list: @entity3897 :: ('MESH:D001285', 'Chemical') :: ['Atropine', 'atropine']

entities_list: @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']

entities_list: @entity11348 :: ('MESH:D006426', 'Chemical') :: ['hemicholinium']

entities_list: @entity1812 :: ('MESH:D001920', 'Chemical') :: ['bradykinin']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity840 :: (10141,Species) :: ['guinea pig']


abstract: 1. Allantoinase [EC 3.5.2.5] was isolated from cells of Candida utilis and unpurified by chromatography on columns of DEAE-cellulose and Sephadex G-200 after treatment with @entity1133 to remove @entity414 oxidase [EC 1.7.3.3.]. 2. The purified allantoinase catalyzed the hydrolysis of @entity13579 into @entity56964 . However, only half of the @entity13579 produced from @entity414 by @entity414 oxidase was converted. The rest of the @entity13579 was unchanged, and showed a negative @entity717 . 3. On the other hand, the combined action of crude @entity414 oxidase and allantoinase resulted in nearly complete conversion of @entity414 into @entity56964 . Furthermore, the unpurified allantoinase preparation hydrolyzed racemic @entity13579 to @entity56964 completely. 4. These results indicate that the @entity414 oxidase produces racemic @entity13579 from @entity414 and that the allantoinase attacks only @entity13579 of positive @entity717 . The results also suggest that @entity13579 racemase is present in the @entity375 cells.

title: Stereospecificity of conversion of XXXX into @entity56964 by enzymes of Canadida utilis.

entities_list: @entity13579 :: ('MESH:D000481', 'Chemical') :: ['allantoin']

entities_list: @entity56964 :: ('MESH:C024081', 'Chemical') :: ['allantoic acid']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['optical rotation']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid', 'urate']

answer: @entity414 :: (MESH:D014527,Chemical) :: ['uric acid']


abstract: 1. Allantoinase [EC 3.5.2.5] was isolated from cells of Candida utilis and unpurified by chromatography on columns of DEAE-cellulose and Sephadex G-200 after treatment with @entity1133 to remove @entity414 oxidase [EC 1.7.3.3.]. 2. The purified allantoinase catalyzed the hydrolysis of @entity13579 into @entity56964 . However, only half of the @entity13579 produced from @entity414 by @entity414 oxidase was converted. The rest of the @entity13579 was unchanged, and showed a negative @entity717 . 3. On the other hand, the combined action of crude @entity414 oxidase and allantoinase resulted in nearly complete conversion of @entity414 into @entity56964 . Furthermore, the unpurified allantoinase preparation hydrolyzed racemic @entity13579 to @entity56964 completely. 4. These results indicate that the @entity414 oxidase produces racemic @entity13579 from @entity414 and that the allantoinase attacks only @entity13579 of positive @entity717 . The results also suggest that @entity13579 racemase is present in the @entity375 cells.

title: Stereospecificity of conversion of @entity414 into XXXX by enzymes of Canadida utilis.

answer: @entity56964 :: (MESH:C024081,Chemical) :: ['allantoic acid']


abstract: A @entity1 with non-contributory family history, at the age of 7 years developed a recurrent @entity508 followed by @entity1662 and @entity410 . She died in a decerebrate state at the age of 10 9/12 years. Diffuse EEG abnormalities changed in accordance with the clinical course. CSF findings were always negative. Brain biopsy performed at the age of 9 5/12 years was non-diagnostic. No clinical signs of @entity1887 were present. Neuropathological examination disclosed severe @entity17 of the cerebral white matter with formation of large periventricular cavities, relative sparing of the subcortical arcuate fibers, and peripheral myelin breakdown of the orthochromatic (neutral fat) type. There was complete absence of inflammatory lesions, comparative preservation of axons and oligodendroglia with moderate astroglial reaction. The optic system and cerebellum were not involved. Additional postanoxic changes were seen in the thalamus and hippocampus. The sporadic case is suggested to represent a cavitating form of @entity8431 which is to be separated from Schilder's @entity7622 and @entity8019 . The etiology of the disorder is unknown.

title: [Cavitating neutral fat XXXX with recurrent course].

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination']

entities_list: @entity508 :: ('MESH:D009128', 'Disease') :: ['ataxic-spastic syndrome']

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['adrenal insufficiency']

entities_list: @entity8431 :: ('MESH:D007966', 'Disease') :: ['neutral fat (simple orthochromatic) leukodystrophy']

entities_list: @entity1662 :: ('MESH:D003244', 'Disease') :: ['disorders of consciousness']

entities_list: @entity7622 :: ('MESH:C537346', 'Disease') :: ['diffuse sclerosis']

entities_list: @entity8019 :: ('MESH:D000326', 'Disease') :: ['adrenoleukodystrophy']

answer: @entity8431 :: (MESH:D007966,Disease) :: ['leukodystrophy']


abstract: The acute effects of the @entity5241 ( @entity3215 ) mixture ( @entity14774 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity35 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity5241 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity5241 treatment resulted in a six-fold increase in amount of @entity1447 . Activities of @entity1110 -cytochrome c reductase, @entity7680 demethylase and @entity14572 diphosphatase were increased whereas @entity413 -6-phosphatase values were decreased by @entity5241 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity5241 -exposed animals. Phospholipids, @entity165 and @entity412 were significantly increased after @entity5241 exposure; however, the greatest percentage increase was seen in the @entity412 pool. The finding of an increase in microsomal @entity412 to phospholipid ratios with exposure to @entity5241 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity653 indicated that the @entity5241 -induced @entity1560 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity368 into microsomal membrane and albumin was somewhat enhanced in @entity35 exposed to @entity5241 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity5241 -induced @entity1560 .

title: Studies on the cellular toxicity of XXXX ( @entity3215 ). I. Effect of @entity3215 on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity35 liver- a morphological and biochemical study.

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty liver']

entities_list: @entity368 :: ('CHEBI:25017', 'Chemical') :: ['leucine']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity3215 :: ('MESH:D011078', 'Chemical') :: ['polychlorinated biphenyls']

entities_list: @entity7680 :: ('MESH:D005036', 'Chemical') :: ['ethylmorphine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity3215 :: (MESH:D011078,Chemical) :: ['polychlorinated biphenyls']


abstract: The acute effects of the @entity5241 ( @entity3215 ) mixture ( @entity14774 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity35 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity5241 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity5241 treatment resulted in a six-fold increase in amount of @entity1447 . Activities of @entity1110 -cytochrome c reductase, @entity7680 demethylase and @entity14572 diphosphatase were increased whereas @entity413 -6-phosphatase values were decreased by @entity5241 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity5241 -exposed animals. Phospholipids, @entity165 and @entity412 were significantly increased after @entity5241 exposure; however, the greatest percentage increase was seen in the @entity412 pool. The finding of an increase in microsomal @entity412 to phospholipid ratios with exposure to @entity5241 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity653 indicated that the @entity5241 -induced @entity1560 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity368 into microsomal membrane and albumin was somewhat enhanced in @entity35 exposed to @entity5241 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity5241 -induced @entity1560 .

title: Studies on the cellular toxicity of @entity3215 ( XXXX ). I. Effect of @entity3215 on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity35 liver- a morphological and biochemical study.

answer: @entity3215 :: (MESH:D011078,Chemical) :: ['PCBs']


abstract: The acute effects of the @entity5241 ( @entity3215 ) mixture ( @entity14774 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity35 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity5241 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity5241 treatment resulted in a six-fold increase in amount of @entity1447 . Activities of @entity1110 -cytochrome c reductase, @entity7680 demethylase and @entity14572 diphosphatase were increased whereas @entity413 -6-phosphatase values were decreased by @entity5241 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity5241 -exposed animals. Phospholipids, @entity165 and @entity412 were significantly increased after @entity5241 exposure; however, the greatest percentage increase was seen in the @entity412 pool. The finding of an increase in microsomal @entity412 to phospholipid ratios with exposure to @entity5241 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity653 indicated that the @entity5241 -induced @entity1560 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity368 into microsomal membrane and albumin was somewhat enhanced in @entity35 exposed to @entity5241 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity5241 -induced @entity1560 .

title: Studies on the cellular toxicity of @entity3215 ( @entity3215 ). I. Effect of XXXX on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity35 liver- a morphological and biochemical study.

answer: @entity3215 :: (MESH:D011078,Chemical) :: ['PCBs']


abstract: The acute effects of the @entity5241 ( @entity3215 ) mixture ( @entity14774 ) on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of @entity35 liver were investigated. Six daily i.p. injections of 25 and 50 mg @entity5241 /kg body weight resulted in increased liver weight and liver to body weight ratios. When compared to controls @entity5241 treatment resulted in a six-fold increase in amount of @entity1447 . Activities of @entity1110 -cytochrome c reductase, @entity7680 demethylase and @entity14572 diphosphatase were increased whereas @entity413 -6-phosphatase values were decreased by @entity5241 exposure. Analysis of liver homogenate and microsomal fraction revealed an increase in lipid in @entity5241 -exposed animals. Phospholipids, @entity165 and @entity412 were significantly increased after @entity5241 exposure; however, the greatest percentage increase was seen in the @entity412 pool. The finding of an increase in microsomal @entity412 to phospholipid ratios with exposure to @entity5241 is suggestive of an increase in membrane-enclosed lipid (liposomes). Studies with labelled @entity653 indicated that the @entity5241 -induced @entity1560 resulted from increased half life but not increased synthesis of liver lipid moieties. The rate of incorporation of @entity368 into microsomal membrane and albumin was somewhat enhanced in @entity35 exposed to @entity5241 indicative of increased protein synthesis. Morphological studies showed increased occurrence of lipid material, both in cytoplasmic droplets and within rough and smooth-surfaced endoplasmic reticulum. Proliferation of smooth endoplasmic reticulum and flattened Golgi cisternae with no secretion granules containing lipoprotein particles characterized the liver from animals exposed for 6 days. The increase in lipid within membranes of the endoplasmic reticulum together with the flattened Golgi lacking typical secretory vesicles indicates a defect in transport of lipoproteins from the endoplasmic reticulum to the Golgi apparatus and may be the cause of the @entity5241 -induced @entity1560 .

title: Studies on the cellular toxicity of @entity3215 ( @entity3215 ). I. Effect of @entity3215 on microsomal enzymes and on synthesis and turnover of microsomal and cytoplasmic lipids of XXXX liver- a morphological and biochemical study.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: This paper describes 3 @entity1 with a severe, generalized @entity1610 with short limbs, shortness of stature, relative @entity4239 and neonatal @entity649 in all cases, @entity2419 in two and dislocation of lenses in one. They died at 7 and 10 weeks and at 17 months respectively. No autopsy was performed on any of the 3 @entity1 . Roentgenological manifestations include short, broad tubular bones with metaphyseal widening, @entity9497 , thigh and forearm bones, neonatal accelerated carpal bone maturation, short, broad pelvis with wide, flared iliac wings, many gross @entity854 including most prominently coronal clefts of almost any vertebral body, and short ribs with flared anterior ends. Roentgenographically the condition has some similarities with @entity45764 , or more correctly, the @entity45764 . However, we think that the clinical and roentgenological manifestations are sufficiently unique to permit delineation of the condition of our 3 @entity1 as a "new" entity different from the @entity45764 . Similar cases have been described by Rolland et al. from France and by Dinno et al. from the U.S.A. The later case and our 3 @entity1 were sporadic cases, but the former had a probably affected sibling, suggesting that this disorder is an autosomal recessive trait.

title: A severe XXXX which resembles @entity45764 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'infants']

entities_list: @entity1610 :: ('MESH:D010009', 'Disease') :: ['chondrodysplasia']

entities_list: @entity4239 :: ('MESH:D008844', 'Disease') :: ['micrognathia']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['vertebral abnormalities']

entities_list: @entity2419 :: ('MESH:D002972', 'Disease') :: ['cleft palate']

entities_list: @entity9497 :: ('MESH:D056305', 'Disease') :: ['bowing of leg']

entities_list: @entity45764 :: ('MESH:C537207', 'Disease') :: ['Kniest disease', 'Kniest chondrodysplasia']

answer: @entity1610 :: (MESH:D010009,Disease) :: ['infantile micromelic chondrodysplasia']


abstract: This paper describes 3 @entity1 with a severe, generalized @entity1610 with short limbs, shortness of stature, relative @entity4239 and neonatal @entity649 in all cases, @entity2419 in two and dislocation of lenses in one. They died at 7 and 10 weeks and at 17 months respectively. No autopsy was performed on any of the 3 @entity1 . Roentgenological manifestations include short, broad tubular bones with metaphyseal widening, @entity9497 , thigh and forearm bones, neonatal accelerated carpal bone maturation, short, broad pelvis with wide, flared iliac wings, many gross @entity854 including most prominently coronal clefts of almost any vertebral body, and short ribs with flared anterior ends. Roentgenographically the condition has some similarities with @entity45764 , or more correctly, the @entity45764 . However, we think that the clinical and roentgenological manifestations are sufficiently unique to permit delineation of the condition of our 3 @entity1 as a "new" entity different from the @entity45764 . Similar cases have been described by Rolland et al. from France and by Dinno et al. from the U.S.A. The later case and our 3 @entity1 were sporadic cases, but the former had a probably affected sibling, suggesting that this disorder is an autosomal recessive trait.

title: A severe @entity1610 which resembles XXXX .

answer: @entity45764 :: (MESH:C537207,Disease) :: ['Kniest disease']


abstract: Antitussive activity and some other related pharmacological properties of @entity70772 were studied. Toxic symptoms in @entity19 and @entity235 were due to the CNS excitation. Acute @entity137 of (AT-17) in @entity19 was slightly (s.c.) or far (p.o.) weaker than that of @entity10425 , but it was three times as toxic as @entity10425 in @entity235 (i.v.). Antitussive efficacy was about 40% of that of @entity10425 in @entity235 , whereas 77% as potent as @entity10425 in @entity468 . It showed no relaxing effect on the bronchial muscle of @entity840 in either normal tone or @entity112 -induced @entity2473 . It had analgesic effect 1/3 as potent as @entity10425 in @entity19 but it was not antagonized by @entity29541 . The prolongation of hexobarbital sleeping time by AT-17 was similar extent to that by @entity10425 . Anti-electroshock effect was half as potent as that of @entity109 . The inhibitory effect on the transportation of intestinal contents in @entity19 was far weaker than that of @entity10425 . Effect on the respiratory and circulatory systems were also investigated.

title: Antitussive activity and other related pharmacological properties of XXXX (AT-17).

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity29541 :: ('MESH:D007977', 'Chemical') :: ['levallorphan']

entities_list: @entity109 :: ('MESH:D010634', 'Chemical') :: ['phenobarbital']

entities_list: @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']

entities_list: @entity70772 :: ('MESH:C012621', 'Chemical') :: ['d-3-methyl-N-methylmorphinan']

answer: @entity70772 :: (MESH:C012621,Chemical) :: ['d-3-methyl-N-methylmorphinan']


abstract: The effect of microelectrophoretically and systemically applied opiates on neuronal discharge activity in the sensorimotor cortex of naive and @entity1286 tolerant/dependent @entity35 has been studied. In naive @entity35 depression of spontaneous discharge activity was the predominant effect of low doses of phoretically applied @entity1286 . Higher doses and repeated application frequently converted this effect into excitation. Only the depressant effect was antagonised by @entity1510 . @entity1510 itself had no effect on spontaneous discharge activity when applied at dose-levels sufficient to antagonise the depressant effect of @entity1286 . @entity14887 mimicked the action of @entity1286 whereas @entity3982 was inactive. @entity1286 depressed the excitatory action of @entity8854 and of @entity934 by a @entity1510 -antagonisable mechanism. Systemic application of @entity3575 mimicked the inhibitory effect of phoretically applied @entity1286 upon transcallosally evoked discharge activity. The late response was markedly depressed whereas the primary response was little affected. Phoretically applied @entity1510 antagonised the effects of systemically applied @entity3575 . In chronically morphinised @entity35 the depressant effect of microelectrophoretically administered @entity1286 was almost lacking and a @entity1510 -resistant excitation became the predominant effect. In these animals the excitant effect of @entity1510 was also increased and the anti- @entity2227 effect and the anti- @entity934 effect of @entity1286 was abolished. The present data speak in favour of a postsynaptically located stereospecific receptor which mediates the inhibitory effects of opiates and which may be involved in the development of acute and chronic tolerance to these drugs.

title: Actions of opiates upon single unit activity in the cortex of naive and tolerant XXXX .

entities_list: @entity8854 :: ('CHEBI:29985', 'Chemical') :: ['L-glutamate']

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

entities_list: @entity14887 :: ('MESH:D007981', 'Chemical') :: ['Levorphanol']

entities_list: @entity1510 :: ('MESH:D009270', 'Chemical') :: ['Naloxone', 'naloxone']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine', 'Morphine']

entities_list: @entity3982 :: ('MESH:D003917', 'Chemical') :: ['dextrorphan']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['Fentanyl']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: Severe @entity1635 causes a deterioration in cardiopulmonary function. The effect of surgical correction on this is variable. We studied the forced vital capacity [FVC) and forced expiratory volume in one second (FEV1) before and after surgical correction in 30 adolescents with @entity2112 and the results are expressed as a percentage of the predicted normal values using 101 @entity1 as controls. A negative correlation was noted preoperatively between the magnitude of the curve and FVC and FEV1. Surgical correction of the curve was done with a Harrington rod in 17 @entity1 followed by cast and brace immobilisation for one and a half years. In the remaining 13 @entity1 the Harrington rod was supplemented with sublaminar wires (SSI) to eliminate the use of an orthoses. All @entity1 had a posterior spinal fusion. Our study showed that there was an improvement in the spirometric values post-operatively but this was not statistically significant. This improvement was similar in both groups of @entity1 . Further studies, for a longer period and of other indices of pulmonary function are required.

title: Spirometric pulmonary function tests before and after surgical correction of XXXX in adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity2112 :: ('MESH:C564593', 'Disease') :: ['idiopathic scoliosis']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

answer: @entity2112 :: (MESH:C564593,Disease) :: ['idiopathic scoliosis']


abstract: UNASSIGNED:     Introduction: This study was carried out to examine whether or not elderly @entity1 on @entity298 ( @entity298 ) had an increased risk of @entity298 .     Methods: This was a retrospective cohort study based on data from the French Language Peritoneal Dialysis Registry. We analyzed 8,396 incident @entity1 starting @entity298 between January 2003 and December 2010. The end of the observation period was 31 December 2012. @entity1 were separated into 2 age groups: up to 75 and over of 75 years old.     Results: Among 8,396 @entity1 starting dialysis there were 3,173 @entity1 older than 75. When using a Cox model, no association was found between age greater than 75 years and increased risk of @entity298 (hazard ratio [HR]: 0.97 [0.88 - 1.07]). @entity6 (HR: 1.14 [1.01 - 1.28] and continuous ambulatory @entity298 (HR: 1.13 [1.04 - 1.23]) were significantly associated with a higher risk of @entity298 whereas nurse-assisted @entity298 was associated with a lower risk of @entity298 (HR: 0.85 [0.78 - 0.94]. In the analysis restricted to the 3,840 self-care @entity298 @entity1 , there was no association between age older than 75 years and risk of @entity298 .     Conclusion: The risk of @entity298 is not increased in elderly @entity1 on @entity298 in a country where assisted @entity298 is available.

title: IS PERITONITIS RISK INCREASED IN ELDERLY XXXX ON PERITONEAL DIALYSIS? REPORT FROM THE FRENCH LANGUAGE PERITONEAL DIALYSIS REGISTRY (RDPLF).

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal dialysis', 'PD', 'peritonitis', 'peritoneal infection']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes']

answer: @entity1 :: (9606,Species) :: ['PATIENTS']


abstract: Allergen-specific @entity9416 ( @entity9416 ) reactions lead to acute degranulation of mast cells and basophils and release of stored mediators, particularly tryptase and @entity112 , which can be measured in vitro after reactions. The aim of this study was to investigate the utility of serum tryptase and plasma @entity112 during @entity1697 ( @entity1697 ) in 103 @entity1 with suspected @entity5419 , in order to support the diagnosis of a @entity9416 -mediated reaction. Blood samples for serum tryptase and plasma @entity112 were collected before the @entity1697 and after the onset of @entity56 or after 60 minutes from test completion. Serum tryptase and plasma @entity112 were measured by a fluoroenzyme immunoassay (ImmunoCAP; ThermoFisher, Uppsala, Sweden) according to the manufacturer  s instructions. A correlation between serum tryptase and plasma @entity112 distributions was observed after @entity1697 (p=0.0035). A correlation was also observed for both serum tryptase and plasma @entity112 before and after @entity1697 (p less than0.0001). Subjects with positive response to @entity1697 had significantly higher values (p = 0.0375) of serum tryptase compared to subjects with negative response. The plasma @entity112 distribution showed a significant difference between measurements before and after @entity1697 , both in the complete population (p less than 0.0001), and considering the response (negative @entity1697 : p less than 0.0001; positive @entity1697 : p=0.0181). The diagnostic work-up of @entity9416 - mediated @entity5419 may include determination of serum tryptase and plasma @entity112 , in order to support the results of @entity1697 . These markers are strongly related to the same @entity9416 -mediated mechanism and, as they can be both easily measured, can confirm the allergic nature of a reaction in the real-life setting of @entity5419 .

title: TRYPTASE AND XXXX MAY SUPPORT ORAL FOOD CHALLENGE IN THE DIAGNOSIS OF ALLERGY.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral food challenge', 'OFC']

entities_list: @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic symptoms']

entities_list: @entity9416 :: ('3497', 'Gene') :: ['immunoglobulin E', 'IgE']

answer: @entity112 :: (MESH:D006632,Chemical) :: ['HISTAMINE']


abstract: OPINION STATEMENT: Approximately 10  % of cases of @entity1892 ( @entity1892 ) harbor a MYC rearrangement and this has been associated with an inferior outcome following standard therapy across many different studies. Double-hit and triple-hit @entity706 harbor concurrent rearrangements of MYC and @entity588 and/or @entity4042 and are also associated with a very aggressive course and poor clinical outcome. It is unclear and there is lack of consensus on how these diseases should be approached therapeutically. They are characterized typically by high tumor proliferation and likely require @entity2109 -type strategies and several retrospective studies suggest that more intensive approaches than rituximab, @entity786 , @entity632 , @entity1891 , and @entity229 (R- @entity3726 ) may be beneficial. One challenge in this respect is that most @entity1 with these diseases are older than 60  years and generally have poor tolerability of regimens typically used in @entity2109 . Dose-adjusted EPOCH-R is an alternative effective immunochemotherapy platform for @entity1892 and is effective in @entity2109 , and retrospective studies suggest that it is effective and feasible in @entity1 with @entity1892 that harbors a MYC rearrangement with or without a @entity588 translocation (double-hit). A multicenter study of this approach in MYC-rearranged @entity1892 is ongoing and preliminary results are very encouraging. There is a lack of consensus on the role of consolidation stem cell transplantation in @entity1 who achieve a good response to initial therapy but at this point in time, no (retrospective) studies have demonstrated any benefit. These diseases are also associated with a high rate of CNS involvement and progression and checking for cerebrospinal fluid by cytology and flow cytometry at initial diagnosis should be considered. In summary, based on retrospective data and preliminary prospective data (as more mature data is awaited), while Burkitt-type regimens may be feasible in young @entity1 , DA-EPOCH-R is a reasonable approach for @entity1 with these diseases, particularly for those over the age of 60  years. CNS prophylaxis is a reasonable consideration (depending on clinical characteristics) given that the rate of CNS progression is high. Many exciting new small molecule inhibitors such as @entity588 and MYC inhibitors are in development and are exciting for these diseases and attempts are underway to combine them with effective immunochemotherapy platforms.

title: XXXX : Optimal Therapy for MYC-positive, Double-Hit, and Triple-Hit @entity1892 .

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity2109 :: ('MESH:D002051', 'Disease') :: ['Burkitt lymphoma']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'diffuse large B cell lymphoma']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

answer: @entity1892 :: (MESH:D016393,Disease) :: ['Aggressive B cell Lymphoma']


abstract: OPINION STATEMENT: Approximately 10  % of cases of @entity1892 ( @entity1892 ) harbor a MYC rearrangement and this has been associated with an inferior outcome following standard therapy across many different studies. Double-hit and triple-hit @entity706 harbor concurrent rearrangements of MYC and @entity588 and/or @entity4042 and are also associated with a very aggressive course and poor clinical outcome. It is unclear and there is lack of consensus on how these diseases should be approached therapeutically. They are characterized typically by high tumor proliferation and likely require @entity2109 -type strategies and several retrospective studies suggest that more intensive approaches than rituximab, @entity786 , @entity632 , @entity1891 , and @entity229 (R- @entity3726 ) may be beneficial. One challenge in this respect is that most @entity1 with these diseases are older than 60  years and generally have poor tolerability of regimens typically used in @entity2109 . Dose-adjusted EPOCH-R is an alternative effective immunochemotherapy platform for @entity1892 and is effective in @entity2109 , and retrospective studies suggest that it is effective and feasible in @entity1 with @entity1892 that harbors a MYC rearrangement with or without a @entity588 translocation (double-hit). A multicenter study of this approach in MYC-rearranged @entity1892 is ongoing and preliminary results are very encouraging. There is a lack of consensus on the role of consolidation stem cell transplantation in @entity1 who achieve a good response to initial therapy but at this point in time, no (retrospective) studies have demonstrated any benefit. These diseases are also associated with a high rate of CNS involvement and progression and checking for cerebrospinal fluid by cytology and flow cytometry at initial diagnosis should be considered. In summary, based on retrospective data and preliminary prospective data (as more mature data is awaited), while Burkitt-type regimens may be feasible in young @entity1 , DA-EPOCH-R is a reasonable approach for @entity1 with these diseases, particularly for those over the age of 60  years. CNS prophylaxis is a reasonable consideration (depending on clinical characteristics) given that the rate of CNS progression is high. Many exciting new small molecule inhibitors such as @entity588 and MYC inhibitors are in development and are exciting for these diseases and attempts are underway to combine them with effective immunochemotherapy platforms.

title: @entity1892 : Optimal Therapy for MYC-positive, Double-Hit, and Triple-Hit XXXX .

answer: @entity1892 :: (MESH:D016393,Disease) :: ['DLBCL']


abstract: OBJECTIVES: CT-guided @entity1068 -mediated renal sympathetic denervation in treatment of therapy-resistant @entity101 was performed to assess @entity1 safety and collect preliminary data on treatment efficacy. MATERIALS AND METHODS: Eleven @entity1 with therapy-resistant @entity101 (blood pressure of >160  mmHg despite three different antihypertensive drugs including a diuretic) and following screening for secondary causes were enrolled in a phase II single arm open label pilot trial of CT-guided neurolysis of sympathetic renal innervation. Primary endpoint was safety, and secondary endpoint was a decrease of the mean office as well as 24-h systolic blood pressure in follow-up. Follow-up visits at 4  weeks, 3, and 6  months included 24-h blood pressure assessments, office blood pressure, laboratory values, as well as full clinical and quality of life assessments. RESULTS: No @entity137 >= 3   occurred. Three @entity1 exhibited worsened kidney function in follow-up analyses. When accounting all @entity1 , office systolic blood pressure decreased significantly at all follow-up visits (maximal mean decrease -41.2  mmHg at 3  months). The mean 24-h systolic blood pressure values decreased significantly at 3  months, but not at 6  months (mean: -9.7 and -6.3  mmHg, respectively). Exclusion of five @entity1 who had failed catheter-based endovascular denervation and/or were incompliant for antihypertensive drug intake revealed a more pronounced decrease of 24-h systolic blood pressure (mean: -18.3 and -15.2  mmHg at 3 and 6  months, p  =  0.03 and 0.06). CONCLUSION: CT-guided sympathetic denervation proved to be safe and applicable under various anatomical conditions with more renal arteries and such of small diameter.

title: Renal Sympathetic Denervation by CT-Guided XXXX Injection: A Phase II Pilot Trial of a Novel Technique.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

answer: @entity1068 :: (MESH:D000431,Chemical) :: ['Ethanol']


abstract: UNASSIGNED: Experience-induced plastic changes in the cerebral cortex are accompanied by alterations in excitatory and inhibitory transmission. Increased excitatory drive, necessary for plasticity, precedes the occurrence of plastic change, while decreased inhibitory signaling often facilitates plasticity. However, an increase of inhibitory interactions was noted in some instances of experience-dependent changes. We previously reported an increase in the number of inhibitory markers in the barrel cortex of @entity19 after fear conditioning engaging vibrissae, observed concurrently with enlargement of the cortical representational area of the row of vibrissae receiving conditioned stimulus (CS). We also observed that an increase of @entity1246 level accompanied the conditioning. Here, to find whether unaltered GABAergic signaling is necessary for learning-dependent rewiring in the @entity19 barrel cortex, we locally decreased @entity1246 production in the barrel cortex or reduced transmission through GABAA receptors (GABAARs) at the time of the conditioning. Injections of @entity31239 ( @entity45581 ), an inhibitor of @entity367 decarboxylase (GAD), into the barrel cortex prevented learning-induced enlargement of the conditioned vibrissae representation. A similar effect was observed after injection of @entity8772 , an antagonist of GABAARs. At the behavioral level, consistent conditioned response (cessation of head movements in response to CS) was impaired. These results show that appropriate functioning of the GABAergic system is required for both manifestation of functional cortical representation plasticity and for the development of a conditioned response.

title: Learning-Dependent Plasticity of the Barrel Cortex Is Impaired by Restricting XXXX -Ergic Transmission.

entities_list: @entity31239 :: ('MESH:D015097', 'Chemical') :: ['3-mercaptopropionic acid']

entities_list: @entity367 :: ('CHEBI:18237', 'Chemical') :: ['glutamic acid']

entities_list: @entity8772 :: ('MESH:C049853', 'Chemical') :: ['gabazine']

answer: @entity1246 :: (MESH:D005680,Chemical) :: ['GABA']


abstract: We have investigated the SX (X = first- or second-row atom), @entity9734 , and @entity37497 molecules employing the correlation-consistent (cc), the recently developed polarization-consistent (pc), and three Pople-type basis sets, in conjunction with the B3LYP functional. The results confirmed that the aug-pc basis sets represent a great contribution in terms of cost-benefits. In the case of the B3LYP functional, when employing the aug-pc-3 and aug-pc-4 basis sets, it is possible to obtain results that are of aug-cc-pV(5+d)Z and aug-cc-pV(6+d)Z quality, respectively, at a much lower cost. The estimations obtained employing smaller members of the family are of nearly double-   quality and do not provide reliable results. There is no basis set of quadruple-   quality among the polarized-consistent basis sets, although in terms of composition, the aug-pc-3 basis set is a QZ basis set. A precise estimation of the Kohn-Sham complete basis set (CBS) limit with the aug-pc-X basis sets is too difficult for the B3LYP functional because the    (aug-pc-4, aug-pc-3, aug-pc-2) extrapolation gives the same results as those of the aug-pc-4 basis set. This is in contrast with the results observed for ab initio methodologies for which the largest basis sets provided the best estimation of the CBS limit. In our opinion, the closest results to the B3LYP/CBS limit are expected to be those obtained with a two-point extrapolation employing the aug-cc-pV(X+d)Z (X = 5, 6) basis sets. The results obtained with this extrapolation are very close to those predicted by the    (aug-pc-3, aug-pc-2, aug-pc-1) extrapolation, and that provides a cheaper but more inaccurate alternative to estimate the CBS limit. Minor problems were found for the aug-pc-X basis sets and the B3LYP functional for molecules in which @entity599 is bound to a very electronegative element, such as SO, SF, @entity9734 , and @entity37497 . For these molecules, the cc basis sets were demonstrated to be more useful. The importance of tight d functions was observed; the total atomization energy of @entity9734 employing the cc-pV6Z basis set is 1 kcal/mol lower than that obtained with the aug-cc-pV(6+d)Z basis set.

title: Basis Set Requirements for XXXX Compounds in Density Functional Theory:    a Comparison between Correlation-Consistent, Polarized-Consistent, and Pople-Type Basis Sets.

answer: @entity599 :: (MESH:D013455,Chemical) :: ['Sulfur']


abstract: UNASSIGNED: Subconjunctival injection is a minimally invasive route for gene delivery to ocular tissues, but has traditionally been limited to use in the @entity267 . The accurate ocular distribution of virus has not, however, been previously investigated. Adenovirus is an attractive gene vector as it can deliver large genes and allow for short-term gene expression, but how safe it is when delivered via subconjunctival injection remains to be established. We have characterized the bio-distribution and safety of subconjunctivally administered adenovirus in Brown @entity35 . The bio-distribution and transgene duration of adenovirus carrying luciferase gene (Ad-Luci) at various time intervals were evaluated via bioluminescence imaging after subconjunctival injection. Adenovirus carrying a reporter gene, b-galactosidase (Ad-LacZ) or hrGFP (Ad-hrGFP) was administered subconjunctivally and the viral distribution in various ocular tissues was assessed by histological analysis and quantitative PCR (qPCR). @entity99 was assessed by biochemical and immunohistological analysis with TUNEL stain. Systemic immunogenicity was assessed by measuring serum level of @entity1505 via ELISA, 2 hours and 14 days after administration of adenovirus. Retinal function was examined by electroretinography. Subconjunctival injection of Ad-Luci induced luciferase expression in the injected eyes within 24 hours, for at least 64 days. Histological analysis showed adenovirus distributed across anterior and posterior ocular tissues. qPCR demonstrated different amounts of adenovirus in different ocular tissues, with the highest amounts closest to the injection site Unlike the intravenous route, subconjunctivally delivered adenovirus did not elicit any detectable @entity99 or systemic immunogenicity. Retinal function was unaffected by adenovirus irrespective of administration route. In conclusion, an adenoviral vector administered subconjunctivally can infiltrate into different ocular tissues and lead to short-term ocular transgene expression, without causing @entity99 and immune activation. Therefore, subconjunctivally administered adenovirus may be a promising gene delivery approach for managing anterior and @entity2194 requiring short-term therapy.

title: Gene Delivery by Subconjunctival Injection of Adenovirus in XXXX : A Study of Local Distribution, Transgene Duration and Safety.

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['posterior segment eye diseases']

entities_list: @entity35 :: ('10116', 'Species') :: ['Norway rats']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic injury', 'Hepatic damage']

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: UNASSIGNED: Splice sites (SSs)-short @entity4334 sequences flanking introns-are under selection for spliceosome binding, and adhere to consensus sequences. However, non-consensus @entity2036 , many of which probably reduce SS performance, are frequent. Little is known about the mechanisms maintaining such apparently suboptimal SSs. Here, we study the correlations between strengths of @entity2036 occupying different positions of the same SS. Such correlations may arise due to epistatic interactions between positions (i.e., a situation when the fitness effect of a @entity4334 in one position depends on the @entity4334 in another position), their evolutionary history, or to other reasons. Within both the intronic and the exonic parts of donor SSs, @entity2036 that increase (decrease) SS strength tend to co-occur with other @entity2036 increasing (respectively, decreasing) it, consistent with positive epistasis. Between the intronic and exonic parts of donor SSs, the correlations of @entity4334 strengths tend to be negative, consistent with negative epistasis. In the course of evolution, substitutions at a donor SS tend to decrease the strength of its exonic part, and either increase or do not change the strength of its intronic part. In acceptor SSs, the situation is more complicated; the correlations between adjacent positions appear to be driven mainly by avoidance of the AG dinucleotide which may cause aberrant splicing. In summary, both the content and the evolution of SSs is shaped by a complex network of interdependences between adjacent @entity2036 that respond to a range of sometimes conflicting selective constraints.

title: Correlated Evolution of XXXX Positions within Splice Sites in Mammals.

entities_list: @entity2036 :: ('MESH:D009711', 'Chemical') :: ['nucleotides']

answer: @entity4334 :: (D009711,Chemical) :: ['Nucleotide']


abstract: Preoperative hysteroscopic and histologic findings of @entity5 were compared with postoperative histologic findings of cervices. A total of 132 @entity1 consisting of 72 @entity2735 , 16 @entity189 and 44 @entity957 were examined during the 5 years beginning in 1977. The rates of @entity5 observed in the endocervix were 33.3% @entity2735 , 56.2% @entity189 and 72.8% @entity957 . The preoperative diagnoses of endocervical lesions were histologically identical with the postoperative ones in 24 (88.9%) of 27 cases of @entity2735 , 7 (87.5%) of 8 cases of @entity189 and all of 30 cases of @entity957 . Mosaics and punctations were noticed in the endocervix near the external os in the early stage of @entity5 , whereas white epithelia were observed more frequently and, over a wide range in the endocervix. @entity854 were noticed predominantly in @entity2735 . Atypical vessels were recognized mainly in @entity189 . Gross irregular and dilated atypical vessels were recognized mainly in @entity189 . Gross irregular and dilated atypical vessels, @entity231 , irregular surface and @entity39 were observed predominantly in @entity189 . In conclusion, hysteroscopy is useful in detecting @entity5 located in the endocervical canal.

title: Usefulness of hysteroscopy for detection of XXXX in the endocervical canal.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2735 :: ('MESH:D002278', 'Disease') :: ['carcinoma in situ']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancerous lesions', 'endocervical cancerous lesions', 'cancer']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['invasive squamous cell carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['microinvasive carcinoma', 'invasive carcinoma']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['Abnormal gland openings']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: An acute experimental @entity625 was induced in the right knee joint of adult @entity468 anesthetized with @entity4486 , and the activity of single fine afferent units of the medial articular nerve was recorded from filaments of the saphenous nerve. All units included in this study were sensitive to local mechanical probing of the medial and anteromedial aspects of the knee joint. The units were identified by their conduction velocity as belonging either to group III (2.5-20 m/s, 48 U) or group IV (less than 2.5 m/s, 29 U). After the identification, the resting activity was measured, and the evoked activity was determined using local mechanical stimulation with glass rods and von Frey hairs, and passive movements of the knee joint. The results were compared with those obtained in a similar study of fine articular units from normal joints. Resting activity was observed in 75% of the group III and 83% of the group IV units. The discharges were irregular and often of high frequency. Both the percentages of units with resting activity and the frequencies of their discharges were more than twice as high as in the control sample. Nearly all units from inflamed joints had low threshold to movements (group III 89%, group IV 72%), and most units responded well to flexion and extension. In contrast, in units from normal joints only 33% of the group III and 10% of the group IV units responded well to passive movements in the normal working range of the joint. In inflamed as well as in normal joints the responses were mostly tonic in character and adapted slowly or not at all when the joint was held in a new position. In normal joints 24% of the group III and 36.5% of the group IV afferent units with local mechanosensitive receptive fields could not be excited by any physiological or noxious joint movements. Such units were only very occasionally seen in the present sample. The average number of receptive fields per unit found in inflamed joints exceeded considerably that in normal units, but no systematic drop in von Frey thresholds was seen when comparing the control sample with the inflamed one. From the above data we conclude that an acute @entity32 sensitizes many fine articular units, making them active at rest and increasing the responsiveness more readily to normally @entity717 . Both nociceptors and units with low threshold to movement seem to become sensitized by the @entity32 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: Effects of an experimental XXXX on the sensory properties of fine articular afferent units.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity4486 :: ('MESH:D002698', 'Chemical') :: ['chloralose']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['innocuous joint movements']

answer: @entity625 :: (MESH:D001168,Disease) :: ['arthritis']


abstract: 1. Very low concentrations of @entity10781 decrease the capacity of @entity35 heart mitochondria, oxidizing @entity2388 plus @entity5910 , to remove @entity141 from the medium. 2. The primary effect is on the rate of @entity141 sequestration; this is reflected in the overall extent of @entity141 removal. 3. @entity10781 has at least two separate actions. Below about 0.5 nmol/mg of protein, it acts solely by competing with @entity141 (Ki = 0.4 muM); above this concentration it also inhibits the production or use of respiratory energy, so that at 1 nmol of @entity10781 /mg of protein, @entity141 removal is almost completely abolished. 4. @entity10781 inhibits coupled and uncoupled respiratory O2 use by mitochondria oxidizing @entity2388 plus @entity5910 , but at higher concentrations than those that affect @entity141 removal; similar concentrations of @entity10781 inhibit @entity2388 uptake, but not @entity5910 uptake, by the mitochondria. 5. Mg2+ only decreases @entity141 removal by competition, and is a far-less effective competitor than @entity10781 (Ki = 0.15 mM). It is possible that the primary cause of the second effect of @entity10781 is displacement of membrane Mg2+. 6. The consequences of these results are discussed in terms of the possible involvement of heart mitochondria in excitation-contraction coupling, and the @entity10781 levels that might occur in heart tissue in vivo.

title: The effect of lead on the calcium-handling capacity of XXXX heart mitochondria.

entities_list: @entity2388 :: ('MESH:D019289', 'Chemical') :: ['pyruvate']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: The impact of local anesthetics on the regulation of @entity413 homeostasis by protein kinase B ( @entity584 ) and @entity1920 -activated protein kinase ( @entity33725 ) is unclear but important because of the implications for both @entity137 and its reversal by IV lipid emulsion (ILE). METHODS: @entity35 received 10 mg/kg @entity1341 over 20 s followed by nothing or 10 ml/kg ILE (or ILE without @entity1341 ). At key time points, heart and kidney were excised. Glycogen content and phosphorylation levels of @entity584 , p70 s6 kinase, s6, insulin receptor substrate-1, @entity9459 , @entity33725 , @entity6625 carboxylase, and @entity2916 2 were quantified. Three animals received Wortmannin to irreversibly inhibit @entity10412 ( @entity10412 ) signaling. Isolated heart studies were conducted with @entity1341 and @entity2306 -a reversible @entity10412 inhibitor. RESULTS: @entity1341 @entity1370 rapidly dephosphorylated @entity584 at S473 to 63    5% of baseline and phosphorylated @entity33725 to 151    19%. @entity33725 activation inhibited targets downstream of @entity1 target of @entity3446 complex 1 via @entity2916 2. Feedback dephosphorylation of @entity10175 to 31    8% of baseline sensitized @entity584 signaling in hearts resulting in hyperphosphorylation of @entity584 at @entity9459 to 390    64% and 293    50% of baseline, respectively. Glycogen accumulated to 142    7% of baseline. Irreversible inhibition of @entity10412 upstream of @entity584 exacerbated @entity1341 @entity1370 , whereas pretreating with a reversible inhibitor delayed the onset of @entity137 . ILE rapidly phosphorylated @entity584 at S473 and T308 to 150    23% and 167    10% of baseline, respectively, but did not interfere with @entity33725 or targets of @entity1 target of @entity3446 complex 1. CONCLUSION: @entity413 handling by @entity584 and @entity33725 is integral to recovery from @entity1341 @entity1370 and modulation of these pathways by ILE contributes to lipid resuscitation.

title: Insulin Signaling in @entity1341 -induced XXXX : Sensitization during Recovery and Potentiation by Lipid Emulsion.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'local anesthetic toxicity']

entities_list: @entity1920 :: ('CHEBI:16027', 'Chemical') :: ["5'-adenosine monophosphate"]

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['rapamycin']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['Bupivacaine', 'bupivacaine']

entities_list: @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity']

entities_list: @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis']

entities_list: @entity10412 :: ('5293', 'Gene') :: ['Pi3K', 'Pi3k', 'phosphoinositide-3-kinase']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity6625 :: ('MESH:D000105', 'Chemical') :: ['acetyl-CoA']

entities_list: @entity9459 :: ('2932', 'Gene') :: ['glycogen synthase kinase-3b', 'T308 and glycogen synthase kinase-3b']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['Glucose', 'glucose']

answer: @entity1370 :: (MESH:D066126,Disease) :: ['Cardiac Toxicity']


abstract: BACKGROUND: The impact of local anesthetics on the regulation of @entity413 homeostasis by protein kinase B ( @entity584 ) and @entity1920 -activated protein kinase ( @entity33725 ) is unclear but important because of the implications for both @entity137 and its reversal by IV lipid emulsion (ILE). METHODS: @entity35 received 10 mg/kg @entity1341 over 20 s followed by nothing or 10 ml/kg ILE (or ILE without @entity1341 ). At key time points, heart and kidney were excised. Glycogen content and phosphorylation levels of @entity584 , p70 s6 kinase, s6, insulin receptor substrate-1, @entity9459 , @entity33725 , @entity6625 carboxylase, and @entity2916 2 were quantified. Three animals received Wortmannin to irreversibly inhibit @entity10412 ( @entity10412 ) signaling. Isolated heart studies were conducted with @entity1341 and @entity2306 -a reversible @entity10412 inhibitor. RESULTS: @entity1341 @entity1370 rapidly dephosphorylated @entity584 at S473 to 63    5% of baseline and phosphorylated @entity33725 to 151    19%. @entity33725 activation inhibited targets downstream of @entity1 target of @entity3446 complex 1 via @entity2916 2. Feedback dephosphorylation of @entity10175 to 31    8% of baseline sensitized @entity584 signaling in hearts resulting in hyperphosphorylation of @entity584 at @entity9459 to 390    64% and 293    50% of baseline, respectively. Glycogen accumulated to 142    7% of baseline. Irreversible inhibition of @entity10412 upstream of @entity584 exacerbated @entity1341 @entity1370 , whereas pretreating with a reversible inhibitor delayed the onset of @entity137 . ILE rapidly phosphorylated @entity584 at S473 and T308 to 150    23% and 167    10% of baseline, respectively, but did not interfere with @entity33725 or targets of @entity1 target of @entity3446 complex 1. CONCLUSION: @entity413 handling by @entity584 and @entity33725 is integral to recovery from @entity1341 @entity1370 and modulation of these pathways by ILE contributes to lipid resuscitation.

title: Insulin Signaling in XXXX -induced @entity1370 : Sensitization during Recovery and Potentiation by Lipid Emulsion.

answer: @entity1341 :: (MESH:D002045,Chemical) :: ['Bupivacaine']


abstract: 1. A study of 24 smelter workers routinely exposed to @entity4447 was conducted to evaluate some characteristics of its absorption and excretion. A statistically significant correlation was found between airborne @entity4447 concentrations below 300 mug/m3 and urinary @entity3494 values below 500 mug/liter. These @entity1 wore personal monitors for five consecutive work days and were determined to have been exposed to average airborne @entity3494 concentrations of 53 mug/m3 (70 mug/m3 of @entity4447 ) which increased their urinary @entity3494 values from 152 mug/liter to 200 mug/liter (an average gain on 32%). 2. The background average urinary @entity3494 value for adult males not exposed to @entity4447 in industry was determined to be 52.6 mug/liter for 204 @entity1 during preemployment examinations. 3. After removal from industrial @entity4447 exposure, the rate of fall in urinary @entity3494 values varies with the magnitude of the urinary @entity3494 level. An initial decrease of 9.5% per day was measured for workers having urinary @entity3494 values below 200 mug/liter. The initial decrease is about 21% per day for workers with urinary @entity3494 values over 600 mug/liter. 4. It was determined that @entity3494 in seafood can alter, in a dramatic fashion, the urinary @entity3494 values determined for smelter workers within 24 hours following consumption. It is recommended, therefore, that the absorption of @entity4447 due to industrial exposure is best evaluated from urine samples collected at least two days after seafood has been eaten.

title: XXXX absorption and excretion in industry.

entities_list: @entity4447 :: ('MESH:C006632', 'Chemical') :: ['arsenic trioxide']

answer: @entity4447 :: (MESH:C006632,Chemical) :: ['Arsenic trioxide']


abstract: UNASSIGNED: The p @entity38044 mutation of the @entity8958 proto-oncogene is associated with a low penetrance of @entity259 ( @entity259 ). Thus, there is a lack in guidelines on management of these @entity1 presenting without a @entity1374 . CLINICAL CASE: A 27-year-old @entity1 presented with a history of severe @entity101 , @entity8942 , diaphoresis and @entity10 . Twenty-four-hour urinary @entity1063 and @entity6531 levels were exclusively up to 20 times the normal limit. CT-scan and MRI found a 35-mm diameter right @entity5 , highly intense in T2- and hypo-intense in T1-weighted image, enhanced after @entity2287 injection. After alpha-adrenergic blocker treatment, a surgical resection of the @entity5 was performed; this latter proved to be a @entity1911 . Genetic screening only revealed a germline p @entity38044 mutation of the @entity8958 proto-oncogene. However, the @entity1 showed no evidence of MEN2: basal calcitonin was normal and @entity460 infusion test was negative. Thyroid ultrasound revealed a TIRADS 3 nodule with benign cytology. Total thyroidectomy was suggested but withheld due to the @entity1 's refusal and a close follow-up was decided. CONCLUSION: This rare case of p @entity38044 mutation-related @entity1911 without evidence of @entity259 questions the indication for prophylactic thyroidectomy in mutation carriers, as recent data challenges its pathogenicity.

title: Questioning the pathogenic role of the p @entity38044 mutation of the XXXX proto-oncogene: Insight from a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6531 :: ('MESH:D009647', 'Chemical') :: ['normetanephrine']

entities_list: @entity1911 :: ('MESH:D010673', 'Disease') :: ['pheochromocytoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'adrenal tumor']

entities_list: @entity8942 :: ('MESH:D013614', 'Disease') :: ['paroxysmal tachycardia']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['medullar thyroid carcinoma', 'MTC']

entities_list: @entity38044 :: ('p|SUB|Y|791|F', 'ProteinMutation') :: ['Tyr791Phe']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease']

answer: @entity8958 :: (5979,Gene) :: ['RET']


abstract: UNASSIGNED: The p @entity38044 mutation of the @entity8958 proto-oncogene is associated with a low penetrance of @entity259 ( @entity259 ). Thus, there is a lack in guidelines on management of these @entity1 presenting without a @entity1374 . CLINICAL CASE: A 27-year-old @entity1 presented with a history of severe @entity101 , @entity8942 , diaphoresis and @entity10 . Twenty-four-hour urinary @entity1063 and @entity6531 levels were exclusively up to 20 times the normal limit. CT-scan and MRI found a 35-mm diameter right @entity5 , highly intense in T2- and hypo-intense in T1-weighted image, enhanced after @entity2287 injection. After alpha-adrenergic blocker treatment, a surgical resection of the @entity5 was performed; this latter proved to be a @entity1911 . Genetic screening only revealed a germline p @entity38044 mutation of the @entity8958 proto-oncogene. However, the @entity1 showed no evidence of MEN2: basal calcitonin was normal and @entity460 infusion test was negative. Thyroid ultrasound revealed a TIRADS 3 nodule with benign cytology. Total thyroidectomy was suggested but withheld due to the @entity1 's refusal and a close follow-up was decided. CONCLUSION: This rare case of p @entity38044 mutation-related @entity1911 without evidence of @entity259 questions the indication for prophylactic thyroidectomy in mutation carriers, as recent data challenges its pathogenicity.

title: Questioning the pathogenic role of the p XXXX mutation of the @entity8958 proto-oncogene: Insight from a case report.

answer: @entity38044 :: (p|SUB|Y|791|F,ProteinMutation) :: ['Tyr791Phe']


abstract: OBJECTIVE: To develop a consensus on a set of key clinical outcomes for the evaluation of preventive interventions for @entity600 in asymptomatic pregnant @entity1 . METHODS: A two-stage web-based Delphi survey and a face-to-face meeting of key stakeholders were used to develop a consensus on a set of critical and important outcomes. We approached five stakeholder groups (parents, midwives, obstetricians, neonatologists, and researchers) from middle- and high-income countries. Outcomes subjected to the Delphi survey were identified by systematic literature review and stakeholder input. Survey @entity1 scored each outcome on a 9-point Likert scale anchored between 1 (limited importance) and 9 (critical importance). They had the opportunity to reflect on total and stakeholder subgroup feedback between survey stages. For consensus, defined a priori, outcomes required at least 70% of @entity1 of each stakeholder group to score them as "critical" and less than 15% as "limited." RESULTS: A total of 228 @entity1 from five stakeholder groups from three lower middle-income countries, seven upper middle-income countries, and 17 high-income countries were asked to score 31 outcomes. Of these @entity1 , 195 completed the first survey and 174 the second. Consensus was reached on 13 core outcomes: four were related to pregnant @entity1 : maternal mortality, maternal @entity281 or @entity32 , prelabor rupture of membranes, and harm to mother from intervention. Nine were related to offspring: gestational age at birth, offspring mortality, birth weight, early neurodevelopmental morbidity, late neurodevelopmental morbidity, gastrointestinal morbidity, @entity281 , @entity1576 , and harm to offspring from intervention. CONCLUSION: This core outcome set for studies that evaluate prevention of @entity600 developed with an international multidisciplinary perspective will ensure that data from trials that assess prevention of @entity600 can be compared and combined. DATABASE REGISTRATION: COMET Initiative, http://www.comet-initiative.org/studies/details/603, Registration Number: 603.

title: A Core Outcome Set for Evaluation of Interventions to Prevent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory morbidity']

answer: @entity600 :: (MESH:D000014,Disease) :: ['Preterm Birth']


abstract: A 62-year-old @entity1 was admitted due to @entity1662 and @entity5785 . Magnetic resonance(MR)images demonstrated watershed @entity1188 in the territory of the left middle cerebral artery, occlusion of the left internal carotid artery, and severe @entity850 of the right internal carotid artery at the neck. He was treated with a recombinant tissue plasminogen activator. One month later, angiography revealed @entity3538 with residual severe @entity850 at the neck. We attempted carotid artery stenting( @entity1741 )on the left internal carotid artery, but could not pass the guide wire through the @entity850 . Therefore, we performed @entity1741 on the right carotid artery instead. At the second day after @entity1741 , the @entity1 showed @entity1662 , @entity1269 , and @entity5785 . MR images showed a new @entity1188 in the left cerebral hemisphere and bilateral multifocal segmental arterial constrictions. By keeping his blood pressure at a high enough level for one week, his symptoms were relieved, and MR images showed resolution of the vessel constrictions. From this case, we can conclude that this kind of @entity2553 after @entity1741 require contrasting treatments to those for @entity751 . Interventionalists should be aware of this condition and its treatments.

title: [Possible Cerebral Infarction due to XXXX after Carotid Artery Stenting:A Case Report].

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['right hemiparesis']

entities_list: @entity3538 :: ('MESH:D002341', 'Disease') :: ['recanalization of the left internal carotid artery']

entities_list: @entity5785 :: ('MESH:D001039', 'Disease') :: ['motor aphasia']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['multiple segmental vasospasms']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions', 'infarction']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['hyperperfusion syndrome']

entities_list: @entity1662 :: ('MESH:D003244', 'Disease') :: ['consciousness disturbance']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity2553 :: (MESH:D020301,Disease) :: ['Multiple Segmental Cerebral Vasospasms']


abstract: UNASSIGNED: The epithelioid variant of malignant @entity1263 (eMPNST) is an extremely rare soft tissue @entity5 comprising less than 5% of all MPNSTs. It is distinguished cytomorphologically from a conventional MPNST by the presence of polymorphous round epithelioid cells arranged in loose clusters with or without spindled @entity5 cells. These features pose a diagnostic challenge because the differential diagnosis involves a variety of mesenchymal and @entity361 including @entity242 , @entity1463 epithelioid @entity1492 , @entity5606 , @entity3580 , @entity189 , and @entity320 . Thus, it may become imperative to perform immunochemical stains on cell blocks of FNA aspirates to arrive at definitive diagnosis. Reports describing the cytologic features of eMPNST are rare. Herein, we report a case of eMPNST with focus on cytomorphologic and cytoimmunochemical features and differential diagnosis. Diagn. Cytopathol. 2015.    2015 Wiley Periodicals, Inc.

title: Fine-needle aspiration cytology of epithelioid malignant XXXX : A case report and review of the literature.

entities_list: @entity1263 :: ('MESH:D010524', 'Disease') :: ['peripheral nerve sheath tumor']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['epithelioid sarcoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplasm']

entities_list: @entity5606 :: ('MESH:D018335', 'Disease') :: ['malignant rhabdoid tumor']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['metastatic carcinomas']

entities_list: @entity1492 :: ('MESH:D005354', 'Disease') :: ['fibrosarcoma']

entities_list: @entity1463 :: ('MESH:D012598', 'Disease') :: ['sclerosing']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['non-mesenchymal tumors']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity1263 :: (MESH:D010524,Disease) :: ['peripheral nerve sheath tumor']


abstract: BACKGROUND: @entity263 ( @entity420 ) is an aggressive variant of conventional @entity420 (CCa) with mixed @entity420 comprising up to 5% of all @entity263 . @entity420 may be underestimated on T2-weighted (T2W) MRI. This study assessed the mp-MRI appearance of @entity420 as compared with CCa. METHODS: With research ethics board approval, we identified 38 @entity1 who underwent mp-MRI (T2W, DWI, and DCE) and radical prostatectomy (RP) between 2012 and 2014. Eight @entity420 in 8 @entity1 and 39 CCa @entity5 foci in 30 consecutive @entity1 were identified. @entity5 volume, apparent diffusion coefficient (ADC;10(-3) mm(2) /s), and time-signal intensity (SI) curves were calculated. Parametric data were compared using the Kruskal-Wallis test and univariate regression. Time-SI curves were compared using the chi-square test. RESULTS: @entity5 volumes were: 1.62(  1.02) for @entity420 , 1.03(  0.54) for Gleason 9, 0.88(  0.93) for Gleason 7/8, and 0.26(  0.14) mL for Gleason 6. There was no difference in size between @entity420 and Gleason 9 (P   =   0.22); however, @entity420 were larger than Gleason 7/8 (P   =   0.03) and Gleason 6 (P   =   0.003) @entity5 . ADC values were: 0.789(  0.22) for @entity420 , 1.01(  0.19) for Gleason 9, 0.992(  0.23) for Gleason 7/8 and 1.389(  0.41) 10(-3) mm(2) /s for Gleason 6 @entity5 . There was no difference in ADC between @entity420 and Gleason 9 (P   =   0.14) or Gleason 7/8 (P   =   0.055) @entity5 . There was a difference in ADC for @entity420 and Gleason >= 7 CCa compared to Gleason 6 @entity5 , (P   <   0.001 and P   =   0.012). All @entity420 demonstrated type III time-SI curves. Gleason   >=    7 @entity5 demonstrated @entity1605 . Gleason 6 @entity5 demonstrated Type I/II time-SI curves. There was no difference in curve type between groups, (P   =   0.18). CONCLUSION: Although @entity420 mimics Gleason score 3   +   3   =   6 @entity5 at T2W MRI; @entity420 resembles Gleason >= 7 CCa on mp-MRI.

title: Multi-parametric (mp) MRI of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['type II/III curves']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['Prostatic ductal adenocarcinoma', 'prostate cancers']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['DCa', 'DCa and CCa tumors', 'adenocarcinoma']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostatic ductal adenocarcinoma']