abstract: UNASSIGNED: With the legalization of recreational marijuana in many states, we anticipate more @entity1 will be using and self-reporting marijuana use in pregnancy. @entity835 is the most common illicit drug used in pregnancy, with a prevalence of use ranging from 3% to 30% in various populations. @entity835 freely crosses the placenta and is found in breast milk. It may have adverse effects on both perinatal outcomes and fetal neurodevelopment. Specifically, marijuana may be associated with fetal growth restriction, @entity2209 , and @entity600 . However, data are far from uniform regarding adverse perinatal outcomes. Existing studies are plagued by confounding by @entity286 and other drug exposures as well as sociodemographic factors. In addition, there is a lack of quantification of marijuana exposure by the trimester of use and a lack of corroboration of maternal self-report with biological sampling, which contributes to the heterogeneity of study results. There is an emerging body of evidence indicating that marijuana may cause problems with neurological development, resulting in @entity2915 , poor cognitive function, and changes in dopaminergic receptors. In addition, contemporary marijuana products have higher quantities of @entity839 than in the 1980s when much of the marijuana research was completed. The effects on the pregnancy and fetus may therefore be different than those previously seen. Further research is needed to provide evidence-based counseling of @entity1 regarding the anticipated outcomes of marijuana use in pregnancy. In the meantime, @entity1 should be advised not to use marijuana in pregnancy or while lactating.

title: XXXX use in pregnancy and lactation: a review of the evidence.

entities_list: @entity839 :: ('MESH:D013759', 'Chemical') :: ['delta-9-tetrahydrocannabinol']

entities_list: @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirth']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth']

entities_list: @entity835 :: ('MESH:D002189', 'Disease') :: ['Marijuana']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperactivity']

answer: @entity835 :: (MESH:D002189,Disease) :: ['Marijuana']


abstract: OBJECTIVE: To characterize the association between commonly used @entity302 ( @entity302 ) and plasma lipid levels in @entity1 with @entity302 . METHODS: We sought observational studies that reported association between commonly used @entity302 and plasma lipid levels in @entity1 . The primary outcome was low-density lipoprotein (LDL) @entity165 . High-density lipoprotein (HDL), total @entity165 and @entity412 were secondary outcomes. The control group included healthy controls, pre-treatment @entity1 or @entity1 treated with other @entity302 . We conducted a systematic search of major bibliographic databases and review of reference lists of primary articles and reviews. Primary comparisons of interest were: AED monotherapy vs. no AED use, monotherapy with one AED vs. other AED, and AED polytherapy vs. no AED use. RESULTS: 31 studies in 4126 @entity1 were identified. @entity2049 , @entity3174 and @entity1092 were the most commonly studied drugs and were also implicated in causing considerable changes in plasma lipid levels in treated @entity1 . There was an increase in LDL and total @entity165 levels with use of these three drugs; however, @entity2049 and @entity3174 were also associated with higher levels of HDL. We could not identify one particular AED which was worse than the other in head-to-head comparison. We were unable to identify a particular polytherapy regimen that was worse than others. CONCLUSION: We found evidence to suggest that some @entity302 may negatively alter lipids levels in @entity1 with @entity302 . Both treating physicians and @entity1 with @entity302 need to be vigilant in managing their vascular risk factors to avoid @entity455 .

title: Antiepileptic drug use for treatment of XXXX and dyslipidemia: Systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'anti-epileptic drugs', 'AEDs']

entities_list: @entity3174 :: ('MESH:D010672', 'Chemical') :: ['phenytoin']

entities_list: @entity2049 :: ('MESH:D002220', 'Chemical') :: ['carbamazepine', 'Carbamazepine']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: INTRODUCTION: Disagreement exists over the ability of different diagnostic tests to define obstruction, indications and timing of surgery and which @entity1 will benefit from surgical intervention in antenatal @entity3041 (ANH) due to @entity4145 ( @entity4145 ). We try to find a way to predict which @entity1 of ANH due to @entity4145 will eventually need surgery during conservative management. MATERIAL AND METHODS: Prospective single centre study involving 122 renal units at a referral centre in India. @entity1 on conservative management were followed using a standard protocol and operated for pre-defined indications defining failure of conservative management. @entity1 who underwent surgery were compared with the non-operated group in terms of sex, side, baseline grade of @entity3041 , maximum anterioposterior diameter on first postnatal ultrasound and differential renal function on first renal scan. RESULTS: A total of 109 renal units qualified for conservative management. Of those, 23.9% required operative intervention during follow-up. Median time to failure of conservative management was 37 weeks. The median follow-up of non-operated cases was 54 months. Univariate analysis revealed that society of fetal urology (SFU) grade of @entity3041 , anteroposterior diameter (APD), @entity121 ( @entity121 ), and pre-operative differential renal function (DRF) had a significant association with surgery (P  <  0.05). Multivariate analysis revealed APD and  pre-operative DRF as the only independent predictors for requiring surgery, while @entity121 and initial SFU grade of @entity3041 were not. Receiver operating curve analysis showed that an APD of 24.3 mm could predict the need for surgery, with a sensitivity of 73.1% and a specificity of 88.0%. CONCLUSIONS: APD and DRF are the predictive factors for surgery. We stop short of recommending surgery only on the basis of APD. Instead we recommend that efforts be made to improve the specificity of this criterion, or by using APD in perspective with the differential renal function. We can reduce the burden of investigations in those with APD <24  mm while those with APD >24  mm can be more comprehensively monitored.

title: Predictors for the need of surgery in antenatally detected XXXX due to UPJ obstruction - A prospective multivariate analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['cortical thickness', 'CT']

entities_list: @entity4145 :: ('MESH:C537373', 'Disease') :: ['ureteropelvic junction obstruction', 'UPJO']

entities_list: @entity3041 :: ('MESH:D006869', 'Disease') :: ['hydronephrosis']

answer: @entity3041 :: (MESH:D006869,Disease) :: ['hydronephrosis']


abstract: BACKGROUND: Molecular tools for detection of low-density asymptomatic @entity3964 infections are needed in @entity311 elimination efforts. This study reports results from the hitherto largest implementation of loop-mediated isothermal amplification (LAMP) for centralized mass screening of asymptomatic @entity311 in Zanzibar. METHODS: Healthy individuals present and willing to participate in randomly selected households in 60 villages throughout Zanzibar were screened for @entity311 by @entity1062 ( @entity1062 ). In 50% of the study households, @entity1 were asked to provide 60  L of finger-prick blood for additional LAMP screening. LAMP was conducted in two centralized laboratories in Zanzibar, by trained technicians with limited or no previous experience of molecular methods. The LAMP assay was performed with Loopamp(TM) MALARIA Pan/Pf Detection Kit (Eiken Chemical Company, Japan). Samples positive for @entity3964 genus (Pan)-LAMP were re-tested using @entity3964 -specific LAMP kits. RESULTS: Paired @entity1062 and LAMP samples were available from 3983 individuals. The prevalence of asymptomatic @entity311 was 0.5% (CI 95% 0.1-0.8) and 1.6% (CI 95% 1.1-2.2) by @entity1062 and Pan-LAMP, respectively. LAMP detected 3.4 (CI 95% 2.2-5.2) times more @entity3964 positive samples than @entity1062 . DNA contamination was experienced, but solved by repetitive decontamination of all equipment and reagents. CONCLUSIONS: LAMP is a simple and sensitive molecular tool, and has potential in active surveillance and mass-screening programmes for detection of low-density asymptomatic @entity311 in pre-elimination settings. However, in order to deploy LAMP more effectively in field settings, protocols may need to be adapted for processing larger numbers of samples. A higher throughput, affordable closed system would be ideal to avoid contamination.

title: Field deployment of loop-mediated isothermal amplification for centralized mass-screening of asymptomatic XXXX in Zanzibar: a pre-elimination setting.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity1062 :: ('MESH:D013736', 'Disease') :: ['RDT', 'rapid diagnostic tests']

entities_list: @entity3964 :: ('5833', 'Species') :: ['Plasmodium falciparum', 'Plasmodium']

answer: @entity311 :: (MESH:D008288,Disease) :: ['malaria']


abstract: In the repair of @entity439 of the descending thoracic aorta, interruption of aortic flow has usually been accomplished by cardiopulmonary bypass, which has been associated with excessive @entity548 due to the systemic heparinization required. To avoid this problem, the authors have used an external (Gott @entity439 ) shunt, which does not require systemic heparinization. In 50 @entity1 with an @entity439 of the descending thoracic aorta a Gott @entity439 shunt was used as an external bypass. The shunt is a flexible, transparent, @entity2634 tube and its heparin-coated wall prevents clotting. Forty-two (84%) @entity1 survived the operation. Thirty-two @entity1 had surgical repair of a traumatic rupture of the descending aorta; 29 (91%) survived. Of 18 @entity1 operated on for an arteriosclerotic @entity439 or a DeBakey type III dissection 13 (72%) survived. Most of the @entity204 occurred early in the series; among the last 14 @entity1 treated for an arteriosclerotic @entity439 or dissection 13 (93%) survived. @entity451 occurred once (2%) because a shunt was accidentally introduced outside the lumen of the descending aorta and therefore did not function. Another @entity1 with an acutely transected aorta and @entity548 had rapid cross-clamping of the aorta without a shunt but suffered a @entity1167 due to postclamping @entity520 . He was successfully resuscitated. No @entity712 , @entity451 or @entity177 occurred in the 48 @entity1 properly protected with the Gott @entity439 shunt. Regardless of their etiology, thoracic @entity439 are unpredictable and the authors recommend surgical treatment in most @entity1 , using this external bypass technique as a method of organ protection.

title: XXXX of the descending thoracic aorta: treatment with the Gott shunt.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity2634 :: ('MESH:D011143', 'Chemical') :: ['polyvinyl chloride']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

entities_list: @entity451 :: ('MESH:C536857', 'Disease') :: ['Paraplegia', 'paraplegia']

answer: @entity439 :: (MESH:D000783,Disease) :: ['Aneurysms']


abstract: UNASSIGNED: @entity238 suzukii (Matsumura) (Diptera: Drosophilidae) is a worldwide emerging pest of soft fruits, but its cold tolerance has not been thoroughly explored. We determined the cold tolerance strategy, low temperature thermal limits, and @entity545 of cold tolerance in both male and female adult D. suzukii. We reared flies under common conditions (long days, 21  C; control) and induced @entity545 by @entity1170 ( @entity1170 , 1h at 0  C followed by 1h recovery), cold acclimation (CA, 5days at 6  C) or acclimation under @entity1054 ( @entity1054 ). D. suzukii had supercooling points (SCPs) between -16 and -23  C, and were chill-susceptible. 80% of control flies were killed after 1h at -7.2  C (males) or -7.5  C (females); CA and @entity1054 improved survival of this temperature in both sexes, but @entity1170 did not. 80% of control flies were killed after 70h (male) or 92h (female) at 0  C, and @entity1054 shifted this to 112h (males) and 165h (females). @entity1054 flies entered chill coma (CTmin) at approximately -1.7  C, which was ca. 0.5  C colder than control flies; @entity1170 and CA increased the CTmin compared to controls. Control and @entity1170 flies exposed to 0  C for 8h took 30-40min to recover movement, but this was reduced to <10min in CA and @entity1054 . Flies placed outside in a field cage in London, Ontario, were all killed by a transient cold snap in December. We conclude that adult phenotypic @entity545 is not sufficient to allow D. suzukii to overwinter in temperate habitats, and suggest that flies could overwinter in association with built structures, or that there may be additional cold tolerance imparted by developmental @entity545 .

title: Adult @entity545 of cold tolerance in a continental-temperate population of XXXX suzukii.

entities_list: @entity545 :: ('MESH:D010411', 'Disease') :: ['plasticity']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['FA', 'fluctuating temperatures']

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

entities_list: @entity1170 :: ('MESH:C564983', 'Disease') :: ['RCH', 'rapid cold-hardening']

answer: @entity238 :: (7227,Species) :: ['Drosophila']


abstract: UNASSIGNED: @entity238 suzukii (Matsumura) (Diptera: Drosophilidae) is a worldwide emerging pest of soft fruits, but its cold tolerance has not been thoroughly explored. We determined the cold tolerance strategy, low temperature thermal limits, and @entity545 of cold tolerance in both male and female adult D. suzukii. We reared flies under common conditions (long days, 21  C; control) and induced @entity545 by @entity1170 ( @entity1170 , 1h at 0  C followed by 1h recovery), cold acclimation (CA, 5days at 6  C) or acclimation under @entity1054 ( @entity1054 ). D. suzukii had supercooling points (SCPs) between -16 and -23  C, and were chill-susceptible. 80% of control flies were killed after 1h at -7.2  C (males) or -7.5  C (females); CA and @entity1054 improved survival of this temperature in both sexes, but @entity1170 did not. 80% of control flies were killed after 70h (male) or 92h (female) at 0  C, and @entity1054 shifted this to 112h (males) and 165h (females). @entity1054 flies entered chill coma (CTmin) at approximately -1.7  C, which was ca. 0.5  C colder than control flies; @entity1170 and CA increased the CTmin compared to controls. Control and @entity1170 flies exposed to 0  C for 8h took 30-40min to recover movement, but this was reduced to <10min in CA and @entity1054 . Flies placed outside in a field cage in London, Ontario, were all killed by a transient cold snap in December. We conclude that adult phenotypic @entity545 is not sufficient to allow D. suzukii to overwinter in temperate habitats, and suggest that flies could overwinter in association with built structures, or that there may be additional cold tolerance imparted by developmental @entity545 .

title: Adult XXXX of cold tolerance in a continental-temperate population of @entity238 suzukii.

answer: @entity545 :: (MESH:D010411,Disease) :: ['plasticity']


abstract: UNASSIGNED: Western diets are high in fat and @entity969 and can influence behavior and gut microbiota. There is growing evidence that altering the microbiome can influence the brain and behavior. This study was designed to determine whether diet-induced changes in the gut microbiota could contribute to alterations in @entity148 , @entity73 . Two-month-old, male C57BL/6 @entity19 were randomly assigned high-fat (42% fat, 43% @entity1735 ( @entity435 ), high- @entity969 (12% fat, 70% @entity435 (primarily @entity969 ) or normal chow (13% kcal fat, 62% @entity435 ) diets. Fecal microbiome analysis, step-down latency, novel object and novel location tasks were performed prior to and 2weeks after diet change. Water maze testing for long- and short-term memory and @entity73 was conducted during weeks 5-6 post-diet change. Some similarities in alterations in the microbiome were seen in both the high-fat and high- @entity969 diets (e.g., increased Clostridiales), as compared to the normal diet, but the percentage decreases in Bacteroidales were greater in the high- @entity969 diet @entity19 . Lactobacillales was only significantly increased in the high- @entity969 diet group and Erysipelotrichales was only significantly affected by the high-fat diet. The high- @entity969 diet group was significantly impaired in early development of a spatial bias for long-term memory, short-term memory and reversal training, compared to @entity19 on normal diet. An increased focus on the former platform position was seen in both high- @entity969 and high-fat groups during the reversal probe trials. There was no significant effect of diet on step-down, exploration or novel recognitions. Higher percentages of Clostridiales and lower expression of Bacteroidales in high-energy diets were related to the poorer @entity73 in the reversal trials. These results suggest that changes in the microbiome may contribute to cognitive changes associated with eating a Western diet.

title: Relationships between diet-related changes in the gut microbiome and XXXX .

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive flexibility', 'memory or cognitive flexibility']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive flexibility']


abstract: BACKGROUND: @entity157 originating from the caudate lobe has a worse prognosis than other @entity157 in another segment of the liver. An isolated caudate lobe resection of the liver represents a significant technical challenge. Caudate lobe resection can be performed along with a lobectomy or as an isolated liver resection. There are very few reports about isolated caudate lobe liver resection. We report a case of successful isolated resection of @entity157 in the caudate lobe with excellent long-term survival. CLINICAL CASE: A 74 years old female with 8cm @entity66 in the caudate lobe without clinical or biochemical evidence of @entity1575 , serum alpha-fetoprotein 3.7 U/l, and negative @entity99 serology was evaluated for surgery. Complete resection of the lesion in 270minutes with Pringle maneuver for 13minutes was satisfactorily performed. @entity1 was discharged ten days after surgery without complications. @entity1 is currently asymptomatic, without deterioration of liver function and 48 month @entity5 free survival after the procedure. CONCLUSION: Isolated caudate lobe resection is an uncommon but technically possible procedure. In order to achieve a successful resection, one must have a detailed knowledge of complete liver anatomy. @entity5 free margins must be obtained to provide long survival for these @entity1 who have a @entity5 in this anatomic location.

title: [ XXXX originated in the caudate lobe. Surgical strategy for resection. A propos of a case].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['mass lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'malignancy']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['Hepatocellular carcinoma', 'hepatocellular carcinoma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']

answer: @entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular carcinoma']


abstract: UNASSIGNED: Background Simplified measures to quantify @entity309 ( @entity309 ) disease activity are increasingly used. The minimally clinically important differences (MCID) for some measures, such as the clinical disease activity index (CDAI), have not been well-defined in real-world clinic settings, especially for early @entity309 @entity1 with low/moderate disease activity. Methods Data from Canadian Early Arthritis Cohort @entity1 were used to examine absolute change in CDAI in the first year after enrollment, stratified by disease activity. MCID cutpoints were derived to optimize the sum of sensitivity and specificity versus the gold standard of @entity1 self-reported improvement or worsening. Specificity, positive predictive value and negative predictive values were calculated against @entity1 self-reported improvement (gold standard) and for change in @entity158 , HAQ and DAS28 improvement. Discrimination was examined using area under receiver operator curves (ROC). Similar methods were used to evaluate MCIDs for worsening for @entity1 who achieved low disease activity. Results A total of 578 @entity1 (mean (SD) age 54.1 (15.3) years; 75% @entity1 , median (IQR) disease duration 5.3 (3.3, 8.0) months) contributed 1169 visit pairs to the improvement analysis. The MCID cutpoints for improvement were 12 ( @entity1 starting in high disease activity, CDAI>22), 6 (moderate, CDAI 10-22), and 1 (low disease activity, CDAI <10). Performance characteristics were acceptable using these cutpoints for @entity158 , HAQ, and DAS28. The MCID for CDAI worsening among @entity1 who achieved low disease activity was 2 units. Conclusions These minimally important absolute differences in CDAI can be used to evaluate improvement and worsening and increase the utility of CDAI in clinical practice. This article is protected by copyright. All rights reserved.

title: Determining the minimally important difference in the clinical disease activity index for improvement and worsening in early XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: Introduction   @entity1689 ( @entity1689 ) can be a cause of recurrent, severe, disabling @entity490 in @entity1 . Surgery has been suggested as a useful therapy, although experience is limited and the results unpredictable. We reviewed our experience of a two-stage protocol-preliminary endoscopic retrograde cholangiopancreatography (ERCP) and duct stenting, and if symptoms resolved, definitive surgical decompression by longitudinal pancreatojejunostomy (LPJ) (Puestow operation). @entity1 and Methods   This is a single-center, retrospective review of @entity1 with established @entity1689 who underwent an LPJ between February 2002 and September 2012. A questionnaire was completed (incorporating @entity227 and lifestyle scores) to assess functional outcome. Data are expressed as median (range). Results   In this study, eight (M:F ratio of 4:4) @entity1 underwent an LPJ and one female @entity1 had a more limited pancreatojejunostomy @entity254 following preliminary ERCP and stent placement where possible. Diagnoses included @entity4306 (n   =   3), idiopathic or structural @entity788 (n   =   5), and duct stricture following radiotherapy (n   =   1). Median duct diameter presurgery was 5 (4-11) mm. Endoscopic placement of a Zimmon pancreatic stent was possible in six with relief of symptoms in all. Median age at definitive surgery was 11 (range, 7-17) years with a median postoperative stay of 9 (range, 7-12) days and a follow-up of 6 (range, 0.5-12) years. All @entity1 reported markedly reduced episodes of @entity158 postprocedure. One developed @entity6 , while three had exocrine deficiency (fecal elastase   <   200   g/g) requiring enzyme supplementation. The @entity1 with limited LPJ had symptomatic recurrence and required restenting and further surgery to widen the @entity254 to become @entity158 free. Conclusion   ERCP and stenting provide a therapeutic trial to assess possible benefit of a definitive duct drainage procedure. LPJ-the modified Puestow operation was safe and complication-free with good medium-term relief of symptoms. We were not able to identify a consistent etiology-associated outcome.

title: Surgical Success in XXXX : Sequential Endoscopic Retrograde Cholangiopancreatography and Surgical Longitudinal Pancreatojejunostomy (Puestow Procedure).

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'child']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual analog scale pain']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity1689 :: ('MESH:D050500', 'Disease') :: ['CP', 'Chronic pancreatitis']

entities_list: @entity4306 :: ('MESH:C537262', 'Disease') :: ['hereditary pancreatitis']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

answer: @entity1689 :: (MESH:D050500,Disease) :: ['Chronic Pancreatitis']


abstract: This paper presents one major theme of findings from a doctorate study. The study used a narrative enquiry approach, to gather parenting narratives of adult @entity1 of parents with @entity1032 . A Partnership Model for a Reflexive Narrative for @entity1 and Researcher (Partnership Model) was used to invite @entity1 into the study, while encouraging a space for reflection for both the adult @entity1 and researcher. In total, 13 adult @entity1 @entity1 constructed their narratives of living with childhood parental @entity1032 , alongside their current parenting role. Their stories reflected childhood experiences of fear and emergence of mistrust of others, particularly their parent with @entity1032 . For some @entity1 , fear and mistrust continued into adulthood. Many adult @entity1 reported their childhood experiences of feeling lonely and isolated. They felt unable to disclose their experiences of parental @entity1032 to others. In addition, @entity1 were unable to access information about their parent's condition, leaving them feeling unprepared and unskilled, despite their childhood desire to help their parent. This furthermore, compounded their sense of fear and isolation. Early identification of @entity1 and families experiencing @entity1032 is important to facilitate dialogue, psychoeducation and support. Social and health professionals have an important opportunity to enhance the social integration and support for families experiencing parental @entity1032 , to reduce long-standing fear, isolation and mistrust.

title: Childhood parental XXXX : living with fear and mistrust.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participant', 'children']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness']

answer: @entity1032 :: (MESH:D008607,Disease) :: ['mental illness']


abstract: @entity5 continues to be a major public health problem in India in the absence of wide spread organised cervical screening programs. Visual inspection of the cervix with @entity1543 (VIA) is an effective, inexpensive screening test that can be combined with simple treatment procedures for early @entity75 , provided by trained health workers. We report 7 years experience in early detection of cervical @entity5 using the VIA test in a community-based program in rural Andhra Pradesh, India where there are no existing organised cervical screening programs. MATERIALS AND METHODS: Eligible @entity1 aged between 26 and 60 were opportunistically screened by trained health wor kers using the VIA test. @entity1 who tested positive were further evaluated and those with @entity75 were treated either by cryotherapy in the screening clinic or referred to a higher center. RESULTS: A total of 18,869 @entity1 were screened by a single round of VIA testing with a positive rate of 10.75%. Biopsy proven high-grade squamous intraepithelials (HSILs) were 90 (0.48%) and low-grade squamous intraepithelials (LSILs) were 43 (0.28%). The overall prevalence of @entity3146 ( @entity3146 ) 2+ lesion rate is 1.05%. A total of 312 (1.65%) cryotherapies were done and 49 @entity1 underwent hysterectomy. CONCLUSIONS: VIA by trained female health workers is a safe, acceptable, and effective test that can save lives from cervical @entity5 even in remote areas with few resources. These results have important implications for efficient service delivery in cervical screening programs in low-resourced settings.

title: Visual Inspection with XXXX (VIA) Screening Program: 7 Years Experience in Early Detection of Cervical @entity5 in Rural South India.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer and pre-cancers', 'cancer', 'Cervical cancer']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['cervical lesions']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

entities_list: @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia', 'CIN']

answer: @entity1543 :: (MESH:D019342,Chemical) :: ['Acetic Acid']


abstract: @entity5 continues to be a major public health problem in India in the absence of wide spread organised cervical screening programs. Visual inspection of the cervix with @entity1543 (VIA) is an effective, inexpensive screening test that can be combined with simple treatment procedures for early @entity75 , provided by trained health workers. We report 7 years experience in early detection of cervical @entity5 using the VIA test in a community-based program in rural Andhra Pradesh, India where there are no existing organised cervical screening programs. MATERIALS AND METHODS: Eligible @entity1 aged between 26 and 60 were opportunistically screened by trained health wor kers using the VIA test. @entity1 who tested positive were further evaluated and those with @entity75 were treated either by cryotherapy in the screening clinic or referred to a higher center. RESULTS: A total of 18,869 @entity1 were screened by a single round of VIA testing with a positive rate of 10.75%. Biopsy proven high-grade squamous intraepithelials (HSILs) were 90 (0.48%) and low-grade squamous intraepithelials (LSILs) were 43 (0.28%). The overall prevalence of @entity3146 ( @entity3146 ) 2+ lesion rate is 1.05%. A total of 312 (1.65%) cryotherapies were done and 49 @entity1 underwent hysterectomy. CONCLUSIONS: VIA by trained female health workers is a safe, acceptable, and effective test that can save lives from cervical @entity5 even in remote areas with few resources. These results have important implications for efficient service delivery in cervical screening programs in low-resourced settings.

title: Visual Inspection with @entity1543 (VIA) Screening Program: 7 Years Experience in Early Detection of Cervical XXXX in Rural South India.

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer and Pre-Cancers']


abstract: UNASSIGNED: Genetic testing for cardiac @entity13192 in @entity944 ( @entity944 ) has developed substantially over the last years. The Next Generation Sequencing (NGS) technology provides an unprecedented opportunity to screen for genetic variations underlying arrhythmogenic genes in a short period of time at a low cost. The present study aimed to perform genetic testing with NGS technologies on the Ion Torrent Personal Genome Machine    (Ion @entity46789   ) sequencer, in targeting a total of 23 genes reported to be associated with @entity299 in order to identify the possible cause of @entity204 in a cohort of post-mortem cases. The molecular analyses focused on 16 cases of @entity944 , aged less than 35 years old. In all cases, the cause of @entity204 could not be determined after a rigorous autopsy associated with histopathological and toxicological analyses according to the guidelines of the Association for European @entity65 . DNA was extracted from fresh frozen tissue. An average of 200 variants was identified per case. However, after the prioritization process using a new scoring program (VaRank) and after the conjunction of clinical data and molecular findings, four "likely pathogenic" variants (including two undescribed variants), were identified in three cases (18.75%) of our cohort in the genes @entity9678 , @entity796 , @entity1788 and @entity23963 . One case, who died during @entity146 hospitalization after administration of a QT prolonging drug, showed a double "likely pathogenic" variant in Long QT genes ( @entity796 and @entity1788 ) which may have predisposed to drug-induced @entity943 . Our study illustrates that the NGS approach based on AmpliSeq    libraries and Ion Torrent PGM    sequencing may be an efficient approach, integrated to post-mortem examination. Given the massive amount of information generated by NGS, a rigorous filtration strategy of variants coupled with multidisciplinary collaboration is crucial to determine the potential pathogenic role of identified variants in the cause of @entity204 .

title: Targeted next generation sequencing application in cardiac XXXX : Analysis of a cohort of autopsy-negative sudden unexplained deaths.

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmias']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['SUD', 'sudden unexplained death']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['inherited cardiac channelopathies']

entities_list: @entity13192 :: ('MESH:D053447', 'Disease') :: ['channelopathies']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular Pathology']

answer: @entity13192 :: (MESH:D053447,Disease) :: ['channelopathies']


abstract: BACKGROUND: Variable results associated with fat grafting have been attributed to local @entity130 , inconsistencies in transfer, and @entity63 before the development of recipient circulation. Remote @entity63 preconditioning is an inexpensive noninvasive technique that has been used in animal models and multicenter clinical trials to protect organ systems. In this work, the authors describe a novel animal model for analyzing the efficacy of fat grafting, and investigate the effect of remote @entity63 preconditioning on volume retention. METHODS: Subcutaneous adipose tissue samples from green fluorescent protein/luciferase-expressing FVB @entity19 were obtained with or without pretreatment with a temporary hind-limb tourniquet. The samples were injected into the dorsal skin folds of wild-type FVB @entity19 . The viability of the transferred tissue was examined over a 28-day period with quantitative bioluminescence after @entity10051 injection. Transferred tissue was also explanted for histologic analysis. RESULTS: The remote @entity63 preconditioning group had significantly increased bioluminescence at days 0, 1, and 28. Histologic analysis at day 28 confirmed the presence of vascularized adipose in both groups. However, significant amounts of @entity82 were found in the control group, whereas substantially less was found in the remote @entity63 preconditioning group. The remote @entity63 preconditioning group retained a substantially greater amount of green fluorescent protein, suggesting increased survival of donor adipocytes. CONCLUSIONS: In this work, the authors describe a novel animal model for quantitative evaluation of fat grafting using in vivo bioluminescence of adipocytes from luciferase-expressing @entity19 . The authors also demonstrate that remote @entity63 preconditioning increases the viability of fat transfer and decreases @entity82 .

title: Remote Ischemic Preconditioning Improves the Viability of Donor Lipoaspirate during XXXX Fat Transfer.

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic']

entities_list: @entity10051 :: ('CHEBI:25078', 'Chemical') :: ['luciferin']

answer: @entity19 :: (10090,Species) :: ['Murine']


abstract: BACKGROUND: About 25% of @entity63 strokes are categorized as cryptogenic (i.e. of unknown cause), but few data exist about the extent of diagnostic testing or treatment. We undertook an international survey to characterize current diagnostic evaluation and antithrombotic management of @entity1 with cryptogenic @entity385 in 2014. AIMS/HYPOTHESIS: To determine the type of diagnostic evaluation undertaken for cryptogenic @entity385 and antithrombotic management and to compare across global regions. METHODS: An 18-question online survey was sent to 995 physicians involved in @entity64 care in 61 countries. Countries were separated into World Bank global regions and income groups. Diagnostic tests were considered routine if performed in >75% of @entity1 at a center. RESULTS: Three hundred one completed surveys were received from 48 countries (response rate    30%). The majority (82%) of hospitals were from high-income countries and mainly from Europe and Central Asia (56%) and North America (19%). For @entity385 @entity1 , magnetic resonance imaging is routinely obtained at 36% of hospitals (highest in North America, 58%). Among cryptogenic @entity64 @entity1 , transesophageal echocardiography is routinely performed in 17% of hospitals. More than 24   hour cardiac rhythm monitoring is done routinely at relatively few (17%) hospitals (highest in North America, 33%). Intracranial arterial imaging is done routinely at 70% of hospitals, with no significant regional differences. Antiplatelet therapies are routinely prescribed for secondary prevention at 94% of hospitals. CONCLUSIONS: Based on self-selected respondents from a large number of international @entity64 centers, transesophageal echocardiography and prolonged (>24   h) cardiac rhythm monitoring are not routinely performed in cryptogenic @entity64 @entity1 , even in high-income countries. Antiplatelet therapy is the global standard for secondary prevention of cryptogenic @entity64 .

title: Global survey of the diagnostic evaluation and management of cryptogenic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: OBJECTIVE: To compare audiometric and functional outcomes between two designs of heat-activated self-crimping stapes prostheses-a modified shape memory circumferential @entity5648 -Teflon piston versus its predecessor-in @entity1 with @entity8719 . STUDY DESIGN: A retrospective analysis of preoperative and postoperative hearing thresholds. SETTING: Tertiary referral center and teaching hospital. @entity1 : One hundred sixty-three consecutive procedures of primary stapes surgery for clinically proven @entity8719 in 108 @entity1 and 55 @entity1 with an average age of 46 years. INTERVENTION: Stapedotomy and insertion of either a standard or a circumferential stapes prosthesis. MAIN OUTCOME MEASURES: Four-frequency pure-tone average preoperative and postoperative air-bone thresholds were recorded. A secondary outcome measure was stability of the implant, as measured by failure rates. RESULTS: Success of closure of the air-bone gap to within 10 dB was achieved in 97% and comparable in both groups (original prosthesis, 23.6; standard deviation, 7.3, with the average reduction seen in the circumferential prosthesis group being 22.6, standard deviation, 5.6). All the differences were not statistically significant using two-way analysis of variance. Failure rate for the original piston was 6%, with no failures seen with the circumferential piston. CONCLUSION: Both prostheses showed comparable postoperative hearing outcomes, with the circumferential prosthesis being found to be more stable.

title: Comparison of Audiometric and Functional Outcomes Between the Standard and Modified 360 XXXX Shape Memory Stapes Prostheses.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'men']

entities_list: @entity8719 :: ('MESH:D010040', 'Disease') :: ['otosclerosis']

answer: @entity5648 :: (MESH:C013616,Chemical) :: ['Nitinol']


abstract: UNASSIGNED: We retrospectively reviewed @entity1 charts to compare the approach-related (convex versus concave) @entity16 and magnitude of correction in @entity1 undergoing lateral lumbar interbody fusion (LLIF). It is yet to be quantitatively determined if correction of adult @entity179 from either side of the curve apex using a LLIF results in a reduction in complications and/or improved corrective ability. The inclusion criteria for this study were @entity1 who underwent a LLIF for adult @entity179 and had the LLIF prior to any other supplemental procedures. @entity1 were grouped based on the approach toward the curve apex concavity (CAVE) or the convexity (VEX). Standard coronal and sagittal radiographic measurements were made. @entity16 and reoperation indications were also recorded. We included 32 @entity1 for review (CAVE: 17; VEX: 15) with a mean age of 65.5 years  a standard deviation of 10.2, and mean follow-up of 17.0months  15.7. There were eight postoperative @entity16 in eight @entity1 (25.0%), and seven reoperations for six @entity1 (18.8%; CAVE: 4/17 [23.5%]; VEX: 2/15 [13.3%]). The CAVE group had 6/17 @entity16 (35.3%; four ipsilateral and two contralateral to approach side) and VEX had 2/15 (13.3%; one ipsilateral and one bilateral to approach side; p>0.05). All @entity1 significantly improved in the mean regional and segmental Cobb angles (p<0.05), except for T11-T12 (p>0.05). There were no significant differences between the groups for any of the radiographic parameters measured (p>0.05). Approaching the curve apex from either the concave or convex side resulted in significant improvements. The concave approach was associated with more postoperative @entity16 .

title: The concave versus convex approach for minimally invasive lateral lumbar interbody fusion for thoracolumbar XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurological complications', 'neurological complications']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative thoracolumbar scoliosis', 'degenerative scoliosis']

answer: @entity179 :: (MESH:D019636,Disease) :: ['degenerative scoliosis']


abstract: INTRODUCTION AND HYPOTHESIS: A relationship between @entity322 and @entity8018 of the urethrovesical junction (UVJ) during pregnancy has been described. The aim of the study was to compare the effects of @entity365 ( @entity365 ) and caesarean section (CS) on UVJ mobility. METHODS: The retrovesical angle (RVA) and the anterior angle between the UVJ and the pubic bone, the pubovesical angle (PVA), were evaluated ultrasonographically in controls and pregnant @entity1 during their first pregnancy between 38 and 40 weeks, and then re-evaluated 6 weeks and 6 months after delivery. All @entity1 completed a validated questionnaire (ICIQ-SF). Differences between and within groups were assessed with Student's t test, the chi-squared test for trend, and one-way two-tailed analysis of variance with Scheff  's post-hoc test. The correlation between PVA and RVA was evaluated using the Spearman R correlation. The positive predictive value, negative predictive value, sensitivity and specificity for the prediction of stress @entity322 (SUI) symptoms were also determined. RESULTS: Included in the study were 42 controls and 217 pregnant @entity1 . PVA at rest, during cough and Valsalva manoeuvre was significantly higher in pregnant @entity1 than in controls and in @entity1 6 weeks after @entity365 in comparison with @entity1 who had undergone CS. @entity1 affected by SUI showed a significantly higher PVA. RVA did not differ between subjects affected or not by SUI symptoms. PVA and RVA were not correlated with each other. CONCLUSIONS: PVA and RVA are increased in pregnant @entity1 in comparison with controls. In @entity1 undergoing @entity365 , PVA is restored significantly later than in those undergoing CS. The change in RVA after pregnancy and delivery seems to persist longer than the change in PVA.

title: Ultrasonographic evaluation of urethrovesical junction mobility: correlation with type of delivery and stress XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity365 :: ('MESH:D014627', 'Disease') :: ['vaginal delivery', 'VD']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence']

entities_list: @entity8018 :: ('MESH:C536196', 'Disease') :: ['hypermobility']

answer: @entity322 :: (MESH:D014549,Disease) :: ['urinary incontinence']


abstract: AIMS: Our study aimed to examine the association between early life stress and early initiation of @entity285 and @entity286 use. DESIGN: This prospective cohort study of @entity1 and @entity1 belongs to the Ukrainian component of the European Longitudinal Study of Pregnancy and Childhood. SETTING: Dniprodzerzhynsk, a city of some 250,000 inhabitants in south central Ukraine. @entity1 : All 4398 @entity1 who visited antenatal clinics between December 25, 1992 and July 23, 1994, planned to continue their pregnancy, and were permanent residents of the city were invited to participate. Of the 4398 invitees, 2148 agreed and 1020 of the mother- @entity1 pairs were available for complete follow-up until the @entity1 were 16years old. MEASUREMENTS: When study @entity1 reached ages 3 and 7, their mothers completed questionnaires about their @entity1 's exposure to and impact from a standard list of recent stressful life events. From the data on event prevalence and severity, we assigned each @entity1 to low, medium, or high early life stress. When the @entity1 became age 16, they completed questionnaires about their history of smoking and drinking. FINDINGS: In multivariate analysis that controlled for current level of family income, current family type, current school type, year of @entity1 's birth, lifetime smoking and current drinking by mother, and education of mother and father, @entity1 with high stress at age 3 had 2.2 times (95% confidence interval: 1.23-4.08) higher odds than @entity1 with low stress to start smoking early. CONCLUSIONS: Our study may be the first to use a longitudinal study design to examine early life stress as a risk factor for early smoking initiation in adolescence.

title: The impact of early life stress on risk of XXXX smoking initiation by adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'girls', 'PARTICIPANTS', 'child']

answer: @entity286 :: (4097,Species) :: ['tobacco']


abstract: In our earlier investigations it has been shown that the gastrointestinal (GI) tract of the @entity1 @entity19 (4-5 days old) can be colonized following a single intragastric challenge with @entity5132 . This makes it possible to investigate the sequence of events which occur during colonization of the GI tract by this opportunistic @entity375 . Two strains of @entity5132 , CA 30 and NS 33, which were shown in earlier studies to differ markedly in their ability to persist in the GI tract were examined. The SEM was used to reveal the location of the @entity375 and their structural association with the surface of tissues of the gut at early times after intragastric inoculation. Animals were sacrificed after challenge, the GI tract was removed from each @entity19 and subdivided into the stomach, upper intestine, mid-intestine, ileum, cecum and large bowel. The number of colony forming units was determined by homogenizing these segments and plating them out on sabouraud's dextrose agar. The microenvironment of each segment was preserved by freezing samples in liquid @entity1568 prior to processing for the SEM. The distribution and level of counts of the strains studied in the GI tract were comparable during the three week period. Both strains of @entity5132 associated with the secreting epithelium and the keratinized epithelium of the stomach. @entity375 also associated with the mucus layer and the epithelial surface throughout the GI tract. Those @entity375 adhering to the epithelial surfaces of the GI tract were frequently covered by a layer of mucus which may aid in colonization.

title: SEM studies of adherence of @entity5132 to the gastrointestinal tract of @entity1 XXXX .

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C. albicans']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: In our earlier investigations it has been shown that the gastrointestinal (GI) tract of the @entity1 @entity19 (4-5 days old) can be colonized following a single intragastric challenge with @entity5132 . This makes it possible to investigate the sequence of events which occur during colonization of the GI tract by this opportunistic @entity375 . Two strains of @entity5132 , CA 30 and NS 33, which were shown in earlier studies to differ markedly in their ability to persist in the GI tract were examined. The SEM was used to reveal the location of the @entity375 and their structural association with the surface of tissues of the gut at early times after intragastric inoculation. Animals were sacrificed after challenge, the GI tract was removed from each @entity19 and subdivided into the stomach, upper intestine, mid-intestine, ileum, cecum and large bowel. The number of colony forming units was determined by homogenizing these segments and plating them out on sabouraud's dextrose agar. The microenvironment of each segment was preserved by freezing samples in liquid @entity1568 prior to processing for the SEM. The distribution and level of counts of the strains studied in the GI tract were comparable during the three week period. Both strains of @entity5132 associated with the secreting epithelium and the keratinized epithelium of the stomach. @entity375 also associated with the mucus layer and the epithelial surface throughout the GI tract. Those @entity375 adhering to the epithelial surfaces of the GI tract were frequently covered by a layer of mucus which may aid in colonization.

title: SEM studies of adherence of XXXX to the gastrointestinal tract of @entity1 @entity19 .

answer: @entity5132 :: (5476,Species) :: ['candida albicans']


abstract: In our earlier investigations it has been shown that the gastrointestinal (GI) tract of the @entity1 @entity19 (4-5 days old) can be colonized following a single intragastric challenge with @entity5132 . This makes it possible to investigate the sequence of events which occur during colonization of the GI tract by this opportunistic @entity375 . Two strains of @entity5132 , CA 30 and NS 33, which were shown in earlier studies to differ markedly in their ability to persist in the GI tract were examined. The SEM was used to reveal the location of the @entity375 and their structural association with the surface of tissues of the gut at early times after intragastric inoculation. Animals were sacrificed after challenge, the GI tract was removed from each @entity19 and subdivided into the stomach, upper intestine, mid-intestine, ileum, cecum and large bowel. The number of colony forming units was determined by homogenizing these segments and plating them out on sabouraud's dextrose agar. The microenvironment of each segment was preserved by freezing samples in liquid @entity1568 prior to processing for the SEM. The distribution and level of counts of the strains studied in the GI tract were comparable during the three week period. Both strains of @entity5132 associated with the secreting epithelium and the keratinized epithelium of the stomach. @entity375 also associated with the mucus layer and the epithelial surface throughout the GI tract. Those @entity375 adhering to the epithelial surfaces of the GI tract were frequently covered by a layer of mucus which may aid in colonization.

title: SEM studies of adherence of @entity5132 to the gastrointestinal tract of XXXX @entity19 .

answer: @entity1 :: (9606,Species) :: ['infant']


abstract: OBJECTIVES: The physical and chemical stability of a preservative-free oral solution of @entity19299 was studied at different pH values and storage temperatures. METHODS: Oral solutions of @entity701 1 mg/mL were prepared by dissolving @entity19299 powder in @entity3736 buffers at pH 4.0, 5.5, and 6.5, or with sterile water (pH 7.4) stored in amber glass vials. Three identical samples of the formulations were prepared and stored under refrigeration (3-7  C), ambient temperature (20-22  C) and high temperature (29-31  C). A 200- L sample was withdrawn from each of the 3 samples immediately after preparation and at 1, 7, 14, 21, and 35 days. Samples were assayed in duplicate using stability-indicating liquid chromatography. Stability was determined by evaluating the percentage of the initial concentration remaining at each time point; stability was defined as the retention of at least 90% of the initial concentration of @entity19299 . RESULTS: At least 92% of the initial @entity19299 concentration in solutions pH 5.5, 6.5, and 7.4 remained throughout the 14-day study period under refrigeration. There were no detectable changes in color, odor, or pH and no visible microbial growth in these samples. In other storage conditions, @entity19299 was rapidly degraded. CONCLUSIONS: The @entity19299 preservative-free oral solutions at pH 5.5, 6.5, or 7.4 are chemically stable when stored under refrigeration for at least 14 days. They provide flexible and convenient dosage forms without any preservatives for pediatric @entity1 .

title: Stability of XXXX Preservative-Free Oral Solutions.

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone']

entities_list: @entity19299 :: ('MESH:C007133', 'Chemical') :: ['hydrocortisone succinate']

answer: @entity701 :: (MESH:D006854,Chemical) :: ['Hydrocortisone']


abstract: Gender disparities in short- and long-term outcomes have been documented in cardiac and valvular heart surgery. However, there is a paucity of data regarding these differences in the @entity4503 ( @entity4503 ) population. The aim of this study was to examine gender-specific differences in short- and long-term outcomes after surgical aortic valve (AV) replacement in @entity1 with @entity4503 . A retrospective analysis was performed in 628 consecutive @entity1 with @entity4503 who underwent AV surgery from April 2004 to December 2013. To reduce bias when comparing outcomes by gender, propensity score matching obtained on the basis of potential confounders was used. @entity1 with @entity4503 who underwent AV surgery presented with more advanced age (mean 60.7    13.8 vs 56.3    13.6 years, p <0.001) and less @entity337 (29% vs 44%, p <0.001) and had a higher risk for in-hospital mortality (mean Ambler score 3.4    4.4 vs 2.5    4.0, p = 0.015). After propensity score matching, @entity1 received more blood products postoperatively (48% vs 34%, p = 0.028) and had more prolonged postoperative lengths of stay (median 5 days [interquartile range 5 to 7] vs 5 days [interquartile range 4 to 6], p = 0.027). Operative, discharge, and 30-day mortality and overall survival were not significantly different. In conclusion, @entity1 with @entity4503 who underwent AV surgery were older, presented with less @entity337 , and had increased co-morbidities, lending higher operative risk. Although @entity1 received more blood products and had significantly longer lengths of stay, short- and long-term outcomes were similar.

title: Comparison of outcomes and presentation in XXXX -versus- @entity1 with bicuspid aortic valves undergoing aortic valve replacement.

entities_list: @entity4503 :: ('MESH:C562388', 'Disease') :: ['bicuspid aortic valve', 'BAV']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation']

answer: @entity1 :: (9606,Species) :: ['men']


abstract: Gender disparities in short- and long-term outcomes have been documented in cardiac and valvular heart surgery. However, there is a paucity of data regarding these differences in the @entity4503 ( @entity4503 ) population. The aim of this study was to examine gender-specific differences in short- and long-term outcomes after surgical aortic valve (AV) replacement in @entity1 with @entity4503 . A retrospective analysis was performed in 628 consecutive @entity1 with @entity4503 who underwent AV surgery from April 2004 to December 2013. To reduce bias when comparing outcomes by gender, propensity score matching obtained on the basis of potential confounders was used. @entity1 with @entity4503 who underwent AV surgery presented with more advanced age (mean 60.7    13.8 vs 56.3    13.6 years, p <0.001) and less @entity337 (29% vs 44%, p <0.001) and had a higher risk for in-hospital mortality (mean Ambler score 3.4    4.4 vs 2.5    4.0, p = 0.015). After propensity score matching, @entity1 received more blood products postoperatively (48% vs 34%, p = 0.028) and had more prolonged postoperative lengths of stay (median 5 days [interquartile range 5 to 7] vs 5 days [interquartile range 4 to 6], p = 0.027). Operative, discharge, and 30-day mortality and overall survival were not significantly different. In conclusion, @entity1 with @entity4503 who underwent AV surgery were older, presented with less @entity337 , and had increased co-morbidities, lending higher operative risk. Although @entity1 received more blood products and had significantly longer lengths of stay, short- and long-term outcomes were similar.

title: Comparison of outcomes and presentation in @entity1 -versus- XXXX with bicuspid aortic valves undergoing aortic valve replacement.

answer: @entity1 :: (9606,Species) :: ['women']


abstract: INTRODUCTION: The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known. MATERIAL AND METHODS: This study included 47 @entity1 with @entity741 (22 @entity1 with @entity1187 and 25 @entity1 with @entity951 ) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity @entity1851 (hs-CRP) and @entity650 ( @entity650 ) were measured. The OCT can detect thin-cap @entity1856 (TCFA), a lesion with high potential for adverse @entity299 . We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers. RESULTS: We observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and @entity650 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and @entity650 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log @entity650 was an independent predictor for TCFA detected by OCT (log @entity650 , 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that @entity650 , compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively). CONCLUSIONS: Peripheral blood levels of both hs-CRP and @entity650 were associated with TCFAs, as detected by OCT. Moreover, @entity650 has a higher potential than hs-CRP for predicting TCFA.

title: Association between inflammatory biomarkers and thin-cap XXXX detected by optical coherence tomography in @entity1 with coronary heart disease.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity951 :: ('MESH:D000787', 'Disease') :: ['effort angina pectoris']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

entities_list: @entity1856 :: ('MESH:D058226', 'Disease') :: ['fibroatheroma']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity1856 :: (MESH:D058226,Disease) :: ['fibroatheroma']


abstract: INTRODUCTION: The relationship between plaque morphology detected by optical coherence tomography (OCT) and inflammatory biomarkers is not well known. MATERIAL AND METHODS: This study included 47 @entity1 with @entity741 (22 @entity1 with @entity1187 and 25 @entity1 with @entity951 ) who underwent percutaneous coronary intervention (PCI). Before PCI, peripheral blood levels of the inflammatory biomarkers high-sensitivity @entity1851 (hs-CRP) and @entity650 ( @entity650 ) were measured. The OCT can detect thin-cap @entity1856 (TCFA), a lesion with high potential for adverse @entity299 . We investigated the relationships between TCFAs in culprit lesions detected by OCT and the peripheral blood levels of these biomarkers. RESULTS: We observed 12 lesions detected as TCFAs. The natural logs of hs-CRP and @entity650 levels in the TCFA group were higher than those in the non-TCFA group (hs-CRP 0.87 (-0.96 to 0.87) vs. -0.47 (-0.92 to 0.30) mg/l, p = 0.027; and @entity650 1.63 (0.63-3.23) vs. 0.53 (-0.21 to 1.05) pg/dl, p = 0.005, respectively). In multivariate logistic regression analysis, log @entity650 was an independent predictor for TCFA detected by OCT (log @entity650 , 0.970 pg/dl, p = 0.023). Receiver operating characteristic curve analysis confirmed that @entity650 , compared to hs-CRP, has a higher area under the curve for predicting TCFA (0.783 vs. 0.715, respectively). CONCLUSIONS: Peripheral blood levels of both hs-CRP and @entity650 were associated with TCFAs, as detected by OCT. Moreover, @entity650 has a higher potential than hs-CRP for predicting TCFA.

title: Association between inflammatory biomarkers and thin-cap @entity1856 detected by optical coherence tomography in XXXX with coronary heart disease.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: This study assessed the efficacy and safety of briakinumab, a human anti-IL-12/23p40 monoclonal antibody, compared with placebo for the induction and maintenance of remission in @entity1 with moderately to severely active @entity30 . METHODS: In this phase 2b, multicenter, double-blind, parallel group study, 246 @entity1 stratified by prior @entity5 necrosis factor-antagonist use and response, were randomized (1:1:1:3) to 4 intravenous induction regimens: placebo, 200, 400, or 700 mg briakinumab, at weeks 0/4/8. At week 12, responders in the placebo or 400-mg induction groups entered the maintenance phase with the same regimen, whereas responders in the 700-mg induction group were rerandomized (1:1:1) to receive placebo, 200, or 700 mg briakinumab at weeks 12/16/20. At week 24, @entity1 in remission stopped receiving study drug (withdrawal phase) until relapse. @entity1 experiencing relapse, nonresponders, and nonremitters could enter the open-label phase. RESULTS: The primary end point of clinical remission at week 6 was not met. There were numerically greater rates of remission and response at 6, 12, or 24 weeks in @entity1 treated with briakinumab. The safety and tolerability profile of briakinumab was similar in the induction and maintenance phases of the trial. CONCLUSIONS: Briakinumab showed a similar safety and tolerability profile to placebo in the induction and maintenance phases, and comparable rates of serious adverse events, adverse events leading to discontinuation, and @entity5 . These data provide support for the potential efficacy of briakinumab and other IL-12/23 inhibitors in the treatment of moderate-to-severe @entity30 .

title: Briakinumab for treatment of XXXX : results of a randomized trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy']

answer: @entity30 :: (MESH:D003424,Disease) :: ['Crohn's disease']


abstract: UNASSIGNED: In vitro differentiation of @entity1 embryonic stem cells (hESCs) into endometrium-like cells may provide a useful tool for clinical treatment. The aim of the present study was to investigate the differentiation potential of hESCs into endometrium-like cells using three methods, which included induction by feeder cells, co-culture with endometrial stromal cells and induction with embryoid bodies. Following differentiation, the majority of cells positively expressed cytokeratin and @entity5960 ( @entity5960 ). Factors associated with endometrium cell function, namely the @entity172 and @entity1420 receptors (ER and PR), were also detected. At day 21 following the induction of differentiation, the expression levels of cytokeratin, @entity5960 , ER and PR were significantly increased in the co-culture method group, as compared with the other two methods. Furthermore, these cells became decidualized in response to @entity1420 and prolactin. In addition, the number of cytokeratin-positive or @entity5960 -positive cells significantly increased following the induction of differentiation using the co-culture method, as compared with the other two methods. The mRNA expression levels of Wnt members that are associated with endometrial development were subsequently examined, and @entity18297 was found to be significantly upregulated in the differentiated cells induced by feeder cells and co-culture with endometrial stromal cells; however, @entity18182 and @entity32533 expression levels were unaffected. Additionally, the mRNA expression levels of @entity18297 in the differentiated cells co-cultured with endometrial stromal cells were higher when compared with those induced by feeder cells. In conclusion, the present findings indicated that the co-culture system is the optimal protocol for the induction of hESC differentiation into endometrium-like cells, and @entity18297 signaling may be involved in this process.

title: Co-culture with endometrial stromal cells enhances the differentiation of XXXX embryonic stem cells into endometrium-like cells.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity5960 :: ('4072', 'Gene') :: ['epithelial cell adhesion molecule', 'EPCAM']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: PURPOSE: Cognitive effort is a clinically important facet of linguistic processing that is often overlooked in the assessment and treatment of @entity1 with @entity2026 (PWA). Furthermore, there is a paucity of valid ways to index cognitive effort in PWA. The construct of cognitive effort has been indexed for decades via pupillometry (measurement of pupil dilation and @entity15496 during a cognitive task), yet pupillometry has not been implemented in studies including PWA. In the present study, we tested a novel method for indexing cognitive effort during linguistic processing in @entity1 with and without @entity2026 . METHOD: Forty control @entity1 and 39 PWA listened to semantically easy and difficult single nouns and looked at images while their pupillary responses were monitored. Mean pupil dilation in response to easy versus difficult nouns was calculated to index cognitive effort. RESULTS: Larger mean pupil dilation values were obtained for difficult compared with easy nouns for both groups. CONCLUSION: Results provide preliminary evidence that pupillometry can be used to index cognitive effort during linguistic processing of single nouns in @entity1 with and without @entity2026 . Methods for indexing cognitive effort will be a valuable addition to existing assessment methods. Suggestions for further research are offered.

title: A Novel Pupillometric Method for Indexing Word Difficulty in Individuals With and Without XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'people']

entities_list: @entity15496 :: ('MESH:D015877', 'Disease') :: ['constriction']

answer: @entity2026 :: (MESH:D001037,Disease) :: ['Aphasia']


abstract: AIM: The present study investigated the effects of @entity2124 ( @entity2124 ), @entity442 ( @entity442 ), @entity2301 ( @entity2301 ) and @entity9045 ( @entity9045 )/exon-3 polymorphism on @entity6 ( @entity6 ) and @entity301 ( @entity301 ) @entity1 . @entity1 AND METHODS: Ninety @entity1 with @entity301 , 90 @entity1 with @entity6 and 96 controls were included in this study. The @entity2124 , @entity442 and @entity2301 serum levels were measured with enzyme-linked immunosorbent assay. @entity9045 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity9045 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity2124 , @entity442 and @entity2301 were not distributed according to @entity9045 /exon-3 variants. However, in the @entity6 group, higher levels of @entity442 and lower levels of @entity2124 and @entity2301 , and in @entity301 group lower levels of @entity442 , @entity2124 and @entity2301 were observed. The order of @entity2124 levels were @entity6 < @entity301 < Controls; @entity442 levels were @entity301 <Controls< @entity6 and @entity2301 levels were @entity301 < @entity6 <Controls. CONCLUSION: No direct effect of @entity9045 /exon-3 polymorphism was observed in @entity6 or @entity301 @entity1 . However @entity2124 , @entity442 , @entity2301 and insulin were thought to act together to establish body homeostasis in @entity1 with @entity6 and @entity301 .

title: The Effect of @entity9045 /exon-3 Polymorphism and Serum @entity2124 , @entity442 and XXXX Levels in @entity301 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus', 'DM']

entities_list: @entity2301 :: ('3486', 'Gene') :: ['insulin-like growth factor binding protein-3', 'IGFBP-3']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease']

entities_list: @entity442 :: ('3479', 'Gene') :: ['insulin-like growth factor-1', 'IGF-1']

answer: @entity2301 :: (3486,Gene) :: ['IGFBP-3']


abstract: AIM: The present study investigated the effects of @entity2124 ( @entity2124 ), @entity442 ( @entity442 ), @entity2301 ( @entity2301 ) and @entity9045 ( @entity9045 )/exon-3 polymorphism on @entity6 ( @entity6 ) and @entity301 ( @entity301 ) @entity1 . @entity1 AND METHODS: Ninety @entity1 with @entity301 , 90 @entity1 with @entity6 and 96 controls were included in this study. The @entity2124 , @entity442 and @entity2301 serum levels were measured with enzyme-linked immunosorbent assay. @entity9045 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity9045 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity2124 , @entity442 and @entity2301 were not distributed according to @entity9045 /exon-3 variants. However, in the @entity6 group, higher levels of @entity442 and lower levels of @entity2124 and @entity2301 , and in @entity301 group lower levels of @entity442 , @entity2124 and @entity2301 were observed. The order of @entity2124 levels were @entity6 < @entity301 < Controls; @entity442 levels were @entity301 <Controls< @entity6 and @entity2301 levels were @entity301 < @entity6 <Controls. CONCLUSION: No direct effect of @entity9045 /exon-3 polymorphism was observed in @entity6 or @entity301 @entity1 . However @entity2124 , @entity442 , @entity2301 and insulin were thought to act together to establish body homeostasis in @entity1 with @entity6 and @entity301 .

title: The Effect of @entity9045 /exon-3 Polymorphism and Serum XXXX , @entity442 and @entity2301 Levels in @entity301 .

answer: @entity2124 :: (2688,Gene) :: ['GH']


abstract: AIM: The present study investigated the effects of @entity2124 ( @entity2124 ), @entity442 ( @entity442 ), @entity2301 ( @entity2301 ) and @entity9045 ( @entity9045 )/exon-3 polymorphism on @entity6 ( @entity6 ) and @entity301 ( @entity301 ) @entity1 . @entity1 AND METHODS: Ninety @entity1 with @entity301 , 90 @entity1 with @entity6 and 96 controls were included in this study. The @entity2124 , @entity442 and @entity2301 serum levels were measured with enzyme-linked immunosorbent assay. @entity9045 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity9045 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity2124 , @entity442 and @entity2301 were not distributed according to @entity9045 /exon-3 variants. However, in the @entity6 group, higher levels of @entity442 and lower levels of @entity2124 and @entity2301 , and in @entity301 group lower levels of @entity442 , @entity2124 and @entity2301 were observed. The order of @entity2124 levels were @entity6 < @entity301 < Controls; @entity442 levels were @entity301 <Controls< @entity6 and @entity2301 levels were @entity301 < @entity6 <Controls. CONCLUSION: No direct effect of @entity9045 /exon-3 polymorphism was observed in @entity6 or @entity301 @entity1 . However @entity2124 , @entity442 , @entity2301 and insulin were thought to act together to establish body homeostasis in @entity1 with @entity6 and @entity301 .

title: The Effect of @entity9045 /exon-3 Polymorphism and Serum @entity2124 , @entity442 and @entity2301 Levels in XXXX .

answer: @entity301 :: (MESH:D003327,Disease) :: ['Diabetes and Coronary Heart Disease']


abstract: AIM: The present study investigated the effects of @entity2124 ( @entity2124 ), @entity442 ( @entity442 ), @entity2301 ( @entity2301 ) and @entity9045 ( @entity9045 )/exon-3 polymorphism on @entity6 ( @entity6 ) and @entity301 ( @entity301 ) @entity1 . @entity1 AND METHODS: Ninety @entity1 with @entity301 , 90 @entity1 with @entity6 and 96 controls were included in this study. The @entity2124 , @entity442 and @entity2301 serum levels were measured with enzyme-linked immunosorbent assay. @entity9045 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity9045 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity2124 , @entity442 and @entity2301 were not distributed according to @entity9045 /exon-3 variants. However, in the @entity6 group, higher levels of @entity442 and lower levels of @entity2124 and @entity2301 , and in @entity301 group lower levels of @entity442 , @entity2124 and @entity2301 were observed. The order of @entity2124 levels were @entity6 < @entity301 < Controls; @entity442 levels were @entity301 <Controls< @entity6 and @entity2301 levels were @entity301 < @entity6 <Controls. CONCLUSION: No direct effect of @entity9045 /exon-3 polymorphism was observed in @entity6 or @entity301 @entity1 . However @entity2124 , @entity442 , @entity2301 and insulin were thought to act together to establish body homeostasis in @entity1 with @entity6 and @entity301 .

title: The Effect of @entity9045 /exon-3 Polymorphism and Serum @entity2124 , XXXX and @entity2301 Levels in @entity301 .

answer: @entity442 :: (3479,Gene) :: ['IGF-1']


abstract: AIM: The present study investigated the effects of @entity2124 ( @entity2124 ), @entity442 ( @entity442 ), @entity2301 ( @entity2301 ) and @entity9045 ( @entity9045 )/exon-3 polymorphism on @entity6 ( @entity6 ) and @entity301 ( @entity301 ) @entity1 . @entity1 AND METHODS: Ninety @entity1 with @entity301 , 90 @entity1 with @entity6 and 96 controls were included in this study. The @entity2124 , @entity442 and @entity2301 serum levels were measured with enzyme-linked immunosorbent assay. @entity9045 /exon-3 variants were determined by multiplex-polymerase chain reaction. RESULTS: The frequency of all alleles and genotypes in all study groups were distributed according to the Hardy-Weinberg equilibrium. In addition, any association between @entity9045 /exon-3 variants and the presence of risk factors were detected. The blood levels of @entity2124 , @entity442 and @entity2301 were not distributed according to @entity9045 /exon-3 variants. However, in the @entity6 group, higher levels of @entity442 and lower levels of @entity2124 and @entity2301 , and in @entity301 group lower levels of @entity442 , @entity2124 and @entity2301 were observed. The order of @entity2124 levels were @entity6 < @entity301 < Controls; @entity442 levels were @entity301 <Controls< @entity6 and @entity2301 levels were @entity301 < @entity6 <Controls. CONCLUSION: No direct effect of @entity9045 /exon-3 polymorphism was observed in @entity6 or @entity301 @entity1 . However @entity2124 , @entity442 , @entity2301 and insulin were thought to act together to establish body homeostasis in @entity1 with @entity6 and @entity301 .

title: The Effect of XXXX /exon-3 Polymorphism and Serum @entity2124 , @entity442 and @entity2301 Levels in @entity301 .

answer: @entity9045 :: (2690,Gene) :: ['GHR']


abstract: BACKGROUND: @entity385 accounts for 85%-90% of all @entity64 and currently has very limited therapeutic options. Recent studies of b-adrenergic antagonists suggest they may have neuroprotective effects that lead to improved functional outcomes in rodent models of @entity385 ; however, there are limited data in @entity1 . We aimed to determine whether there was an improvement in mortality rates among @entity1 who were taking b-blockers during the acute phase of their @entity385 . METHODS: A retrospective analysis of a prospectively collected database of @entity385 @entity1 was performed. @entity1 who were on b-adrenergic antagonists both at home and during the first 3 days of hospitalization were compared with @entity1 who were not on b-adrenergic antagonists to determine the association with @entity1 mortality rates. RESULTS: The study included a @entity1 population of 2804 @entity1 . In univariate analysis, use of b-adrenergic antagonists was associated with older age, @entity955 , @entity101 , and more-severe @entity64 . Despite this, multivariable analysis revealed a reduction in in-hospital mortality among @entity1 who were treated with b-adrenergic antagonists (odds ratio, .657; 95% confidence interval, .655-.658). CONCLUSIONS: The continuation of home b-adrenergic antagonist medication during the first 3 days of hospitalization after an @entity385 is associated with a decrease in @entity1 mortality. This supports the work done in rodent models suggesting neuroprotective effects of b-blockers after @entity385 .

title: Effect of b-Adrenergic Antagonists on In-Hospital Mortality after XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'initial stroke presentation']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'Ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']


abstract: BACKGROUND: The @entity11708 is the prime medial stabiliser of the knee and is a commonly injured structure which leads to valgus instability of the knee. OBJECTIVES: We aim to analyse differences in recovery of knee motion and muscle function over one year follow up in the @entity11708 and combined ACL- @entity11708 injured knee. We hypothesized that combined ACL- @entity130 lead to greater knee motion and muscle function deficits at 1 year. METHODS: @entity11708 (Group I) or combined ACL- @entity130 (Group II) from 2006-2010 were included. Those with a previous @entity130 , @entity130 or presenting 2 weeks post-injury were excluded. At certain outpatient follow up intervals, we recorded pre-determined parameters of knee function. Follow-up was at weeks 2, 6, 12, 26, 52. RESULTS: The cohort included 82 @entity1 (54 males:28 females) with a mean age of 32 (range 16-56). Group II showed a deficit in Total Range of Movement (TROM) and flexion at 6 month follow up (p  <  0.05). Group II showed an extension deficit at week 2 (p  <  0.05). The Peak Torque Deficit (PTD) and Average Power Deficit (APD) improved for quadriceps and hamstrings across all follow up intervals (p  >  0.05). CONCLUSION: There is a @entity717 at 6 months in group II, resolving by 1 year. There was no difference in PTD or APD in either group.

title: Recovery of knee function in the XXXX and combined ACL- @entity11708 deficient knee.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['TROM and flexion deficit']

entities_list: @entity11708 :: ('OMIM:150800', 'Disease') :: ['Isolated MCL', 'MCL', 'isolated MCL']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['MCL injury', 'MCL injuries', 'injury to contralateral limb']

answer: @entity11708 :: (OMIM:150800,Disease) :: ['isolated MCL']


abstract: BACKGROUND: The @entity11708 is the prime medial stabiliser of the knee and is a commonly injured structure which leads to valgus instability of the knee. OBJECTIVES: We aim to analyse differences in recovery of knee motion and muscle function over one year follow up in the @entity11708 and combined ACL- @entity11708 injured knee. We hypothesized that combined ACL- @entity130 lead to greater knee motion and muscle function deficits at 1 year. METHODS: @entity11708 (Group I) or combined ACL- @entity130 (Group II) from 2006-2010 were included. Those with a previous @entity130 , @entity130 or presenting 2 weeks post-injury were excluded. At certain outpatient follow up intervals, we recorded pre-determined parameters of knee function. Follow-up was at weeks 2, 6, 12, 26, 52. RESULTS: The cohort included 82 @entity1 (54 males:28 females) with a mean age of 32 (range 16-56). Group II showed a deficit in Total Range of Movement (TROM) and flexion at 6 month follow up (p  <  0.05). Group II showed an extension deficit at week 2 (p  <  0.05). The Peak Torque Deficit (PTD) and Average Power Deficit (APD) improved for quadriceps and hamstrings across all follow up intervals (p  >  0.05). CONCLUSION: There is a @entity717 at 6 months in group II, resolving by 1 year. There was no difference in PTD or APD in either group.

title: Recovery of knee function in the @entity11708 and combined ACL- XXXX deficient knee.

answer: @entity11708 :: (OMIM:150800,Disease) :: ['MCL']


abstract: Lower body positive pressure (LBPP), or 'anti-gravity' treadmills   have become increasingly popular among elite distance runners. However, to date, few studies have assessed the effect of body weight support ( @entity1053 ) on the metabolic cost of running among elite runners. This study evaluated how @entity1053 influenced the relationship between velocity and metabolic cost among 6 elite male distance runners. @entity1 ran three- 16 minute tests consisting of 4 stages of 4 minutes at 8, 7, 6 and 5 min  mile(-1) pace (3.35, 3.84, 4.47 and 5.36 m  s(-1)), while maintaining an aerobic effort (Respiratory Exchange Ratio  <=1.00). One test was run on a regular treadmill, one on an anti-gravity treadmill with 40% @entity1053 and one with 20% @entity1053 being provided. Expired gas data were collected and regression equations used to determine and compare slopes. Significant decreases in @entity26 uptake ( @entity4962 ) were found with each increase in @entity1053 (p < 0.001). At 20% @entity1053 , the average decrease in net VO2 was greater than proportional (34%), while at 40% @entity1053 , the average net reduction in VO2 was close to proportional (38%). Across velocities, the slope of the relationship between VO2 and velocity (  @entity4962 /  v) was steeper with less support. The slopes at both the 20% and 40% @entity1053 conditions were similar, especially when compared to the regular treadmill. Variability in VO2 between athletes was much greater on the LBPP treadmill and was greater with increased levels of @entity1053 . In this study we evaluated the effect of body weight support on @entity4962 among elite distance runners. We have shown that @entity26 uptake decreased with support, but not in direct proportion to that support. Further, because of the high variability in @entity26 uptake between athletes on the LBPP treadmill, prediction equations may not be reliable and other indicators (heart rate, perceived exertion or directly measured @entity26 uptake) should be used to guide training intensity when training on the LBPP treadmill. Key pointsWith increasing amounts of @entity1053 ( @entity1053 ), the slope of the relationship between velocity and @entity26 consumption (  @entity4962 /  v) decreases significantly. This means the change in @entity26 consumption (VO2) is significantly smaller over a given change in velocity at higher amounts of @entity1053 .There is a non-linear decrease in VO2 with increasing @entity1053 . As such, with each increment in the amount of @entity1053 provided, the reduction in VO2 becomes increasingly smaller.This paper provides first of its kind data on the effects of @entity1053 on the cost of running among highly trained, elite runners. The outcomes of this study are in line with previous findings among non-elite runners.

title: XXXX consumption of elite distance runners on an anti-gravity treadmill  .

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1053 :: ('MESH:D001835', 'Disease') :: ['BWS', 'body weight-support']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['Oxygen']


abstract: The skeletal muscle in aged @entity35 adapts rapidly following a period of exercise. This adaptation includes structural remodeling and biochemical changes such as an up-regulation of antioxidant enzymes, content of stress and @entity1457 proteins (HSPs). However, the associated molecular mechanisms mediating different types of exercise training-induced adaptations are not yet completely understood. Therefore, the purpose of this study was to investigate the effects of duration and frequency exercise on the expression of HSPs, antioxidant enzymes, and mitogen-activated protein kinase (MAPKs) in the skeletal muscles of aged @entity35 . Young (3-month-old) and aged (20-month-old) male @entity35 were randomly assigned to 6 groups and extensor digitorum longus (EDL; fast twitch muscle fiber) and soleus (SOL; slow twitch muscle fiber) skeletal muscles were collected immediately. The expression pattern of HSPs in skeletal muscles was decreased in old groups compared with young groups. Especially, HSPs showed lower expression in SOL than EDL muscle. Interestingly, HSPs in aged @entity35 was increased significantly after S1 (single long-duration; 1*30 min, 5 days/week for 6 weeks) and M1 types (multiple short-duration; 3*10 min  day(-1), 5 days  week(-1) for 6 weeks) than S2 (single long-duration; 1*30 min, 3 days/week for 6 weeks) and M2 (multiple short-duration; 3*10 min  day(-1), 3 days  week(-1) for 6 weeks) types of exercise training. Also, @entity224 dismutase (SODs) showed similar expression as HSP did. On the contrary, the p-ERK and p-JNK were down regulated. In addition, p-p38 level in the SOL muscle was activated markedly in all exercise groups. These results demonstrate that increasing of HSP expression through duration and frequency exercise can lead to protection and training-induced adaptation against aging-induced @entity425 . Key pointsThe expression of @entity1457 proteins (HSPs) in aged @entity35 was increased significantly after single long-duration (S1) and multiple short-duration (M1) types than S2 and M2 types of exercise training in soleus (SOL) skeletal muscles.Superoxide dismutase (SODs) showed similar expression as HSPs did. On the contrary, the p-ERK and p-JNK were down regulated. In addition, p-p38 level in the SOL muscle was activated markedly in all exercise groups.Induction of HSPs and SODs by high duration and frequency of exercise training such as S1 and M1 types with concomitant MAPKs pathway depending on the type of muscles.The frequency and duration of exercise training could affect the functional adaptation and protection against aging-induced @entity425 through changing expression of related molecules.

title: Expression of XXXX Proteins (HSPs) in Aged Skeletal Muscles Depends on the Frequency and Duration of Exercise Training.

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat shock']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['structural weakness in skeletal muscles', 'structural weakness of skeletal muscles']

answer: @entity1457 :: (MESH:D012769,Disease) :: ['Heat Shock']


abstract: UNASSIGNED: Knowing the subcellular compartments of @entity1 proteins is essential to shed light on the mechanisms of a broad range of @entity1 diseases. In computational methods for protein subcellular localization, knowledge-based methods (especially @entity74 ( @entity74 ) based methods) are known to perform better than sequence-based methods. However, existing @entity74 -based predictors often lack interpretability and suffer from overfitting due to the high dimensionality of feature vectors. To address these problems, this paper proposes an interpretable multi-label predictor, namely mLASSO-Hum, which can yield sparse and interpretable solutions for large-scale prediction of @entity1 protein subcellular localization. By using the one-vs-rest @entity17031 -based classifiers, 87 out of more than 8000 @entity74 terms are found to play more significant roles in determining the subcellular localization. Based on these 87 essential @entity74 terms, we can decide not only where a protein resides within a cell, but also why it is located there. To further exploit information from the remaining @entity74 terms, a method based on the @entity74 hierarchical information derived from the depth distance of @entity74 terms is proposed. Experimental results show that mLASSO-Hum performs significantly better than state-of-the-art predictors. We also found that in addition to the @entity74 terms from the cellular component category, @entity74 terms from the other two categories also play important roles in the final classification decisions. For readers*  convenience, the mLASSO-Hum server is available online at http://bioinfo.eie.polyu.edu.hk/mLASSOHumServer/.

title: mLASSO-Hum: A LASSO-based interpretable XXXX -protein subcellular localization predictor.

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['gene ontology', 'GO']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: This retrospective medical chart review aimed to provide a current, real-world overview of biologic usage in @entity1 with @entity309 ( @entity309 ) in Germany, Spain, and the UK, and estimate clinical and healthcare utilization outcomes associated with early versus late treatment. Adults (>= 18  years) with a confirmed @entity309 diagnosis between January 2008 and December 2010, who received biologic treatment for >= 3  months and had >= 12  months of follow-up were included. Early treatment was receipt of biologic agent  <=1  year after @entity309 diagnosis. Outcomes included 28-joint disease activity score (DAS28) reduction of >= 1.2 from biologic start and remission (DAS28  <  2.6). Time to outcome was evaluated using Kaplan-Meier curves and log-rank tests. Of 328 @entity1 enrolled (Germany [n  =  111], Spain [n  =  106], UK [n  =  111]), 58.2  % received early biologic (Germany: 55.0  %, UK: 55.9  %, Spain: 64.2  %; p  =  0.321). First-line biologics were more frequent in Spain (26.4  %) and Germany (19.8  %) versus the UK (7.2  %; p  <  0.001). Late-treated @entity1 were hospitalized more often than early-treated @entity1 (10.5 vs 2.9  % [p  =  0.006] for 9.0 vs 5.4 mean inpatient days [p  =  0.408]). DAS28 was 5.1 at biologic initiation (n  =  310); 73.5  % of @entity1 had a DAS28 decrease of >= 1.2 and 44.5  % achieved remission. More @entity1 had DAS28 decrease of >= 1.2 (79.2 vs 65.9  %; p  =  0.009) and remission (51.1 vs 35.6  %; p  =  0.007) with early versus late treatment, with a significant difference in Kaplan-Meier curves when indexing on time since diagnosis (p  <  0.001) and biologic start (p  =  0.024). In @entity309 @entity1 receiving biologic therapy, over half received biologic therapy early. Early initiation was associated with improved clinical outcomes and reduced hospitalization rates versus late treatment.

title: A European chart review study on early XXXX treatment patterns, clinical outcomes, and healthcare utilization.

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: INTRODUCTION: @entity1 with invasive @entity320 are commonly referred for @entity1600 ( @entity1600 ) detection. A recently proposed 3D tomographic imaging modality is freehand SPECT (declipseSPECT). This "bedside system" was originally developed to enable minimal-invasive image-guided surgery. The aim of this retrospective analysis was to assess the clinical use of this freehand detector device for image-guided lymphatic mapping in @entity320 @entity1 . MATERIALS AND METHODS: Thirty-nine @entity1 (12 female and 27 male subjects) were included (age, 30-79 years). All of them had at least one location of @entity320 with @entity5 stage pT1b or greater in 37 and pTx in 2 @entity1 in different sites of the body (abdomen in 4, back in 14, head and neck in 5, lower extremity in 6, and @entity2045 in 10 @entity1 ). Lymphoscintigraphy was performed with 65 to 127 MBq Tc-nanocolloid. A 2-day protocol was applied with SPECT-CT acquisition (Brightview XCT, Philips) at day 1 and surgery using radio-guided freehand SPECT at day 2. SPECT-CT data were integrated into the 3D navigation system to enable fast and direct localization of the @entity1600 by displaying the depth of the node from the skin surface and lateral margins in relation to the gamma probe. RESULTS: Comparable preoperative imaging and intraoperative localization was observed in 18 @entity1 . In 14 cases, more lymph nodes were resected than detected by SPECT-CT including 1 @entity1 without evidence of an @entity1600 because this node was located close to the primary @entity5 . In 10 of these @entity1 , intraoperative freehand SPECT revealed additional sites of lymph nodes. In 7 cases, more findings were detected by SPECT-CT than surgically removed. The procedure was safe and easy to perform, and the time of surgical intervention using freehand SPECT was in the range of 36 to 133 minutes (mean time, 66.56 minutes). CONCLUSIONS: Freehand SPECT detected more @entity1600 compared with SPECT-CT, and the tracking system provided precise anatomical localization of the radioactive-labeled SLNs.

title: Clinical Usefulness of a Novel Freehand 3D Imaging Device for Radio-Guided Intraoperative Sentinel Lymph Node Detection in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['upper extremity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumoral', 'right ear tumor']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['sentinel lymph node', 'SLN']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'malignant melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['Malignant Melanoma']