abstract: BACKGROUND AND PURPOSE: Controversy persists over statins and risk of @entity1779 . We determined associations of premorbid lipid-lowering therapy and outcomes among @entity1 of the Intensive Blood Pressure Reduction in Acute @entity1779 Trials (INTERACT). METHODS: The pooled data of INTERACT 1 and 2 (international, multicenter, prospective, open, blinded end point, randomized controlled trials of @entity1 with @entity1779 [<6 hours] and elevated systolic blood pressure) were analyzed with regard to associations of baseline lipid-lowering treatment and clinical outcomes of 3184 @entity1 in a multivariate model. Associations of lipid-lowering therapy and @entity1410 growth (baseline to 24 hours) in computed tomographic substudies @entity1 (n=1310) were estimated in ANCOVA. RESULTS: Among 204 @entity1 (6.5%) with baseline lipid-lowering treatment, 90-day clinical outcomes were not significantly different after adjustment for confounding variables including region and age. In the computed tomographic substudy, 24-hour @entity1410 growth was greater in 124 @entity1 (9%) with, compared with those without, prior lipid-lowering therapy. However, this association was not significant between groups (9.2 versus 6.8 mL; P<0.13), after adjustment for prior antithrombotic therapy. CONCLUSIONS: No independent associations were found between lipid-lowering medication and adverse outcomes in @entity1 with @entity1779 . CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.

title: No Relationship of Lipid-Lowering Agents to XXXX Growth: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute @entity1779 Trials Studies.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['Cerebral Hemorrhage', 'intracerebral hemorrhage']

answer: @entity1410 :: (MESH:D006406,Disease) :: ['Hematoma']


abstract: BACKGROUND AND PURPOSE: Controversy persists over statins and risk of @entity1779 . We determined associations of premorbid lipid-lowering therapy and outcomes among @entity1 of the Intensive Blood Pressure Reduction in Acute @entity1779 Trials (INTERACT). METHODS: The pooled data of INTERACT 1 and 2 (international, multicenter, prospective, open, blinded end point, randomized controlled trials of @entity1 with @entity1779 [<6 hours] and elevated systolic blood pressure) were analyzed with regard to associations of baseline lipid-lowering treatment and clinical outcomes of 3184 @entity1 in a multivariate model. Associations of lipid-lowering therapy and @entity1410 growth (baseline to 24 hours) in computed tomographic substudies @entity1 (n=1310) were estimated in ANCOVA. RESULTS: Among 204 @entity1 (6.5%) with baseline lipid-lowering treatment, 90-day clinical outcomes were not significantly different after adjustment for confounding variables including region and age. In the computed tomographic substudy, 24-hour @entity1410 growth was greater in 124 @entity1 (9%) with, compared with those without, prior lipid-lowering therapy. However, this association was not significant between groups (9.2 versus 6.8 mL; P<0.13), after adjustment for prior antithrombotic therapy. CONCLUSIONS: No independent associations were found between lipid-lowering medication and adverse outcomes in @entity1 with @entity1779 . CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT00226096 and NCT00716079.

title: No Relationship of Lipid-Lowering Agents to @entity1410 Growth: Pooled Analysis of the Intensive Blood Pressure Reduction in Acute XXXX Trials Studies.

answer: @entity1779 :: (MESH:D002543,Disease) :: ['Cerebral Hemorrhage']


abstract: BACKGROUND AND PURPOSE: Language barriers may lead to poor quality of care, particularly for conditions like @entity64 for which diagnosis and treatment decision making rely on taking an accurate @entity1 history. The purpose of this study was to determine the impact of @entity1 language barriers on quality of @entity64 care and clinical outcomes. METHODS: This retrospective cohort study used data from the Registry of the Canadian @entity64 Network. All Ontario @entity1 who were admitted with @entity64 or transient @entity63 attack between July 2003 and March 2008 were selected. Mortality, @entity64 outcomes, in-hospital complications, quality of care, and disposition were compared between those without (n=12 787) and with (n=1506) language barriers, which was defined based on the @entity1 's preferred language. Hierarchical multivariable regression models determined the effect of language barriers, independent of baseline covariates. RESULTS: @entity1 with language barriers had better 7-day mortality than those without (7.0% versus 9.2%; OR, 0.69; 95% CI, 0.57-0.82; P<0.001). However, they were more likely to be discharged with a moderate-to-severe @entity51 (65.9% versus 51.5%; OR, 1.25; 95% CI, 1.15-1.35). In-hospital complication rates did not differ, and quality of care indicators generally favored @entity1 with language barriers. CONCLUSIONS: @entity1 who had language barriers had reduced mortality and better performance on some quality of care measures. These differences existed despite adjustment for many potential confounders, including ethnicity, prognostic factors, and @entity64 characteristics.

title: Impact of Language Barriers on XXXX Care and Outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke', 'acute stroke']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: BACKGROUND: In the largest @entity2598 ( @entity2598 ) outbreak in history, nosocomial transmission of  @entity2598 increased spread of the disease. We report on 2 instances in Sierra Leone where @entity1 unknowingly infected with @entity2598 were admitted to a general hospital ward (1 pediatric ward and 1 maternity ward), exposing health care workers, caregivers, and other @entity1 to @entity2598 . Both @entity1 died on the general wards, and were later confirmed as being infected with @entity2598 . We initiated contact tracing and assessed risk factors for @entity325 to guide containment recommendations. METHODS: We reviewed medical records to establish the index @entity1 ' symptom onset. Health care workers, @entity1 , and caregivers were interviewed to determine exposures and personal protective equipment (PPE) use. Contacts were monitored daily for @entity2598 symptoms. Those who experienced @entity2598 symptoms were isolated and tested. RESULTS: Eighty-two contacts were identified: 64 health care workers, 7 caregivers, 4 @entity1 , 4 newborns, and 3 @entity1 of @entity1 . Seven contacts became symptomatic and tested positive for @entity2598 : 2  health care workers (1 nurse and 1 hospital cleaner), 2 caregivers, 2 newborns, and 1 @entity1 . The infected nurse placed an intravenous catheter in the pediatric index @entity1 with only short gloves PPE and the hospital cleaner cleaned the operating room of the maternity ward index @entity1 wearing short gloves PPE. The maternity ward index @entity1 's caregiver and newborn were exposed to her body fluids. The infected @entity1 and her newborn shared the ward and latrine with the maternity ward index @entity1 . Hospital staff members did not use adequate PPE. Caregivers were not offered PPE. CONCLUSIONS: Delayed recognition of @entity2598 and inadequate PPE likely led to exposures and @entity325 . Earlier recognition of @entity2598 and adequate PPE might have reduced direct contact with body fluids. Limiting nonhealth-care worker contact, improving access to PPE, and enhancing screening methods for pregnant @entity1 , @entity1 , and inpatients may help decrease @entity2598 transmission in general health care settings.

title: Nosocomial transmission of XXXX on pediatric and  maternity wards: Bombali and Tonkolili, Sierra Leone, 2014.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'patients', 'patient']

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['secondary infections']

entities_list: @entity2598 :: ('MESH:D019142', 'Disease') :: ['Ebola virus disease', 'EVD']

answer: @entity2598 :: (MESH:D019142,Disease) :: ['Ebola virus disease']


abstract: BACKGROUND: @entity17550 are common in @entity191 ( @entity191 ) and respond poorly to medication. This study aimed to analyze the risk factors for @entity17550 in @entity191 . METHODS: Ninety-one @entity1 with @entity191 (aged 34-83 years old) were recruited. @entity1 were assessed with the Unified @entity191 Rating Scale (UPDRS), Hoehn and Yahr stage, Pittsburgh Sleep Quality Index (PSQI), @entity308 (HAMD), and @entity148 ( @entity148 ). Micturition number was recorded, and Type B ultrasound was used to evaluate residual urine. Statistics was performed using binary logistic regression, bivariate correlations, and Chi-square and t-tests. RESULTS: Of 91 @entity1 , @entity1973 occurred in 55.0%. Among these, 49.5% suffered with @entity2183 , 47.3% with pollakiuria. @entity2183 number had a positive linear relationship with @entity148 score (odds ratio [OR] = 0.340, P = 0.001), HAMD score (OR = 0.323, P = 0.002), duration of @entity3034 medication (OR = 0.328, P = 0.001), dose of @entity3034 (OR = 0.273, P = 0.009), UPDRS-II (OR = 0.402, P = 0.000), UPDRS-III score (OR = 0.291, P = 0.005), and PSQI score (OR = 0.249, P = 0.017). Micturition number over 24 h was positively associated with @entity148 (OR = 0.303, P = 0.004) and UPDRS-II scores (OR = 0.306, P = 0.003). Of @entity1 with residual urine, 79.3% had a volume of residual urine <50 ml. Residual urine was present in 44.4% of the @entity1 with @entity2183 , 46.5% of the @entity1 with pollakiuria, and 80.0% of the @entity1 with @entity3833 . More @entity1 than @entity1 had residual urine (35.2% male vs. 13.3% female; P = 0.002). CONCLUSIONS: @entity2183 and pollakiuria were common micturition symptoms in our @entity1 with @entity191 . @entity2183 was associated with @entity308 , @entity148 , @entity25 , and severity of @entity191 . Pollakiuria was associated with @entity148 and severity of @entity191 . Male @entity1 were more prone to residual urine and pollakiuria.

title: Investigation of XXXX in @entity191 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Patients', 'patients', 'men']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'Hamilton Depression Rating Scale']

entities_list: @entity17550 :: ('MESH:D014555', 'Disease') :: ['urination disorders', 'Urination disorders']

entities_list: @entity1973 :: ('MESH:D001750', 'Disease') :: ['urinary dysfunction']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['Hamilton Anxiety Scale', 'HAMA', 'anxiety']

entities_list: @entity2183 :: ('MESH:D053158', 'Disease') :: ['nocturia', 'Nocturia']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep problems']

answer: @entity17550 :: (MESH:D014555,Disease) :: ['Urination Disorder']


abstract: BACKGROUND: @entity17550 are common in @entity191 ( @entity191 ) and respond poorly to medication. This study aimed to analyze the risk factors for @entity17550 in @entity191 . METHODS: Ninety-one @entity1 with @entity191 (aged 34-83 years old) were recruited. @entity1 were assessed with the Unified @entity191 Rating Scale (UPDRS), Hoehn and Yahr stage, Pittsburgh Sleep Quality Index (PSQI), @entity308 (HAMD), and @entity148 ( @entity148 ). Micturition number was recorded, and Type B ultrasound was used to evaluate residual urine. Statistics was performed using binary logistic regression, bivariate correlations, and Chi-square and t-tests. RESULTS: Of 91 @entity1 , @entity1973 occurred in 55.0%. Among these, 49.5% suffered with @entity2183 , 47.3% with pollakiuria. @entity2183 number had a positive linear relationship with @entity148 score (odds ratio [OR] = 0.340, P = 0.001), HAMD score (OR = 0.323, P = 0.002), duration of @entity3034 medication (OR = 0.328, P = 0.001), dose of @entity3034 (OR = 0.273, P = 0.009), UPDRS-II (OR = 0.402, P = 0.000), UPDRS-III score (OR = 0.291, P = 0.005), and PSQI score (OR = 0.249, P = 0.017). Micturition number over 24 h was positively associated with @entity148 (OR = 0.303, P = 0.004) and UPDRS-II scores (OR = 0.306, P = 0.003). Of @entity1 with residual urine, 79.3% had a volume of residual urine <50 ml. Residual urine was present in 44.4% of the @entity1 with @entity2183 , 46.5% of the @entity1 with pollakiuria, and 80.0% of the @entity1 with @entity3833 . More @entity1 than @entity1 had residual urine (35.2% male vs. 13.3% female; P = 0.002). CONCLUSIONS: @entity2183 and pollakiuria were common micturition symptoms in our @entity1 with @entity191 . @entity2183 was associated with @entity308 , @entity148 , @entity25 , and severity of @entity191 . Pollakiuria was associated with @entity148 and severity of @entity191 . Male @entity1 were more prone to residual urine and pollakiuria.

title: Investigation of @entity17550 in XXXX .

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: PURPOSE: To evaluate the influence of the needle size used for intravitreal (IVT) injections on @entity1 ' @entity158 experience in a randomized, double-armed, single-blinded, clinical trial. METHODS: @entity1 included were randomized to have an IVT injection performed with a 27-gauge needle (group 1) or with a 30-gauge needle (group 2). The topical anaesthesia before the injection was standardized. Immediately after the injection, @entity1 were asked to grade their @entity158 using the visual analogue scale (VAS) and the Wong-Baker FACES scale. The main outcome measure was the @entity158 score assessment. Cofactors analysed were @entity1 ' demographics (age and gender) and clinical characteristics (such as the number of previous IVT injections). In addition, scaled surgeon's questionnaires to assess the IVT injection procedure were evaluated. For statistical analysis, a regression model was used. RESULTS: The data of 208 @entity1 (group 1: 104 @entity1 ; group 2: 104 @entity1 ) were analysed. There was no significant difference in the VAS @entity158 scores (p  >  0.18) and in the Wong-Baker @entity158 scores (p  >  0.59) between both treatment groups. Gender (p  =  0.0288) and the number of previous IVT injections (p  =  0.0028) significantly influenced the VAS @entity158 scores (p  <  0.05). Female @entity1 and @entity1 with a history of previous IVT injections had higher @entity158 scores. The surgeon's questionnaire showed an overall preference towards the use of a 30-gauge needle for IVT injections. CONCLUSION: The use of a 30-gauge needle for IVT injections showed no significant effect in @entity158 relief compared to the use of a 27-gauge needle. However, a 30-gauge needle was preferred by all surgeons.

title: Needle size in intravitreal injections - XXXX evaluation of a randomized clinical trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: The linear no-threshold model (LNT) was recommended in 1956, with abandonment of the traditional threshold dose-response for genetic risk assessment. Adoption of LNT by the International Commission on Radiological Protection (ICRP) became the standard for radiation regulation worldwide. The ICRP recommends a dose limit of 1 mSv/ @entity2073 r for the public, which is too low and which terrorizes innocent peop @entity1 deed, LNT arose mainly from the lifespan survivor study (LSS) of atomic bomb survivors. The LSS, which asserts linear dose-response and no threshold, is challenged mainly on three points. 1) Radiation doses were underestimated by half because of disregard for major residual radiation, resulting in canc @entity5 k overestimation. 2) The dose and dose-rate effectiveness factor (DDREF) of 2 is used, but the actual DDREF is estimated as 16, resulting in canc @entity5 k overestimation by several times. 3) Adaptive response (hormesis) is observed in leuk @entity1778 solid canc @entity5 es, consistently contradicting the linearity of LNT. Dras @entity5 k moves the dose-response curve close to the control line, allowing the setting of a threshold. Living organisms have been evolving for 3.8 billion years under radiation exposure, naturally acquiring various defense mechanisms such as DNA repair mechanisms, apoptosis, and immune response. The failure of LNT lies in the neglect of carc @entity105 these biological mechanisms. Obstinate application of LNT continues to cause tremendous huma @entity1 cial, and economic losses. The 60-year-old LNT must be rejected to establish a new scientific knowledge-based system.

title: Tremendous XXXX , Social, and Economic Losses Caused by Obstinate Application of the Failed Linear No-threshold Model.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'people']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Drastic reduction of cancer', 'cancer']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: CONTEXT: There are limited studies on comparison of Total etch (TE) and @entity14062 ( @entity3149 ) adhesive for placement of sealants. AIMS: The aim of the study was to compare the retention of fissure sealants placed using TE adhesive to those sealants placed using @entity3149 ( @entity3149 ) adhesive. SETTINGS AND DESIGN: The study was conducted in the dental section, Aga Khan University Hospital. This study was a randomized single blinded trial with a @entity2133 design. MATERIALS AND METHODS: The study included 37 @entity1 , 101 teeth were included in both study groups. The intervention arm was treated with @entity3149 Adhesive (Adper Easy One, 3M ESPE, US). Control arm received TE adhesive (Adper Single Bond 2, 3M ESPE, US) before sealant application. The @entity1 were followed after 6 months for assessment of sealant retention. STATISTICAL ANALYSIS USED: Interexaminer agreement for outcome assessment was assessed by Kappa Statistics and outcome in intervention group was assessed by McNemar's test. RESULTS: Ninety-one pairs of molar (90%) were reevaluated for sealant retention. Complete retention was 56% in TE arm and 28% in @entity3149 arm with an odds ratio (OR) of 3.7. CONCLUSIONS: Sealants applied with TE adhesives show higher rate of complete sealant retention than @entity3149 adhesive.

title: A randomized control clinical trial of fissure sealant retention: XXXX adhesive versus total etch adhesive.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['split mouth']

entities_list: @entity3149 :: ('MESH:D020190', 'Disease') :: ['seventh generation', 'SE']

answer: @entity14062 :: (MESH:D012652,Disease) :: ['Self etch']


abstract: INTRODUCTION: Photoselective vaporization of the prostate ( @entity12468 ) has been widely adopted as a surgical treatment for lower urinary tract symptoms due to @entity1067 ( @entity1067 ). Recently, a high-powered 180 W @entity15171 (LBO) laser has become commercially available and there is relatively little information on the impact of this very high-powered laser on perioperative outcomes. Even more so is the impact of the laser on outcomes according to prostate size. OBJECTIVES: The objective of this study was to evaluate perioperative outcomes after @entity12468 with the 180W laser, relative to prostate size. @entity1 AND METHODS: A prospectively maintained institutional ethics approved database was retrospectively reviewed. Subjects were analyzed according to transrectal ultrasound and categorized into groups namely 0-39 mL, 40-79 mL, 80-120 mL and >120 mL. Perioperative measures included energy utilized, length of operation, duration catheterization, post operative length of stay (POLOS), Clavien-Dindo adverse events and number discharged home within 24 hours catheter free. RESULTS: With increasing prostate size, there was a statistically significant increase in energy utilization and operation time (P < 0.01 between groups). Duration of catheterization, POLOS, incidence of Grade 3 and above Clavien-Dindo adverse events and discharge home catheter free within 24 hours was not statistically significant across groups. CONCLUSIONS: Prostate volume impacts upon energy utilized with @entity12468 surgery. Prostate volume does not influence duration of catheterization or POLOS. Clavien-Dindo Grade 3 or greater adverse events were low and do not appear to be influenced by prostate size. The ability to be discharged home catheter free within 24 hours likewise does not appear to be influenced by prostate size.

title: Does prostate size impact upon perioperative outcomes associated with photoselective vaporization of the prostate using the 180W XXXX laser?

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS']

entities_list: @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia', 'BPH']

entities_list: @entity15171 :: ('MESH:C021051', 'Chemical') :: ['lithium triborate']

answer: @entity15171 :: (MESH:C021051,Chemical) :: ['lithium triborate']


abstract: OBJECTIVE: We reviewed our experience of surgery for @entity302 ( @entity302 ) with or without history of @entity739 . METHODS: Data were reviewed from 65 (33 male) @entity1 with @entity302 who underwent surgery between 1993 and 2014; palliative cases were excluded. RESULTS: Mean age at surgery was 5.1 (range 0.2-19) years, with mean postsurgical follow-up of 45.3 (6-120) months. Mean number of anticonvulsants used preoperatively was 4.2 (2-8), which decreased to 1.2 (0-4) postoperatively (p < 0.0001). Total hemispherectomy was the most commonly performed surgery (n = 20), followed by subtotal hemispherectomy (n = 17), multilobar resection (n = 13), lobectomy (n = 7), tuberectomy (n = 6), and lobectomy + tuberectomy (n = 2), with International League Against @entity302 (ILAE) class I outcome in 20, 10, 7, 6, 3, and 0 @entity1 , respectively (total 46/65 (71%); 22 off medication). Shorter duration of @entity302 (p = 0.022) and presence of magnetic resonance imaging (MRI) lesion (p = 0.026) were independently associated with class I outcome. Of 34 @entity1 operated <3 years after @entity410 onset, 30 (88%) achieved class I outcome. Thirty-seven (79%) of 47 @entity1 with lesional MRI had class-I outcome, whereas 9 (50%) of 18 with normal MRI had class I outcome. Positron emission tomography (PET) scan was abnormal in almost all @entity1 [61 (97%) of 63 with lateralizing/localizing findings in 56 (92%) of 61 @entity1 , thus helping in surgical decision making and guiding subdural grid placements, particularly in @entity1 with nonlesional MRI. Fifteen @entity1 had @entity260 , mostly minor. SIGNIFICANCE: @entity302 surgery in @entity302 @entity1 , with or without history of @entity739 , is best accomplished at an early age and in those @entity1 with @entity66 on MRI with electroencephalography (EEG) concordance. Good outcomes can be achieved even when there is no MRI lesion but positive PET localization.

title: Surgical treatment for refractory XXXX : The Detroit series.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['lesional abnormalities']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity739 :: ('MESH:D013036', 'Disease') :: ['infantile spasms']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['Curative epilepsy', 'epilepsy', 'epileptic spasms', 'ES', 'Epilepsy']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epileptic spasms']


abstract: UNASSIGNED: PURPOSE Of THE STUDy To compare the clinical results of @entity174 operated by superior locking plate using either horizontal or vertical incision by physical examination and nerve conduction tests. MATERIAL AnD METHODS Between January 2010 and January 2013, 63 @entity1 with displaced midshaft @entity174 were treated with superior locking plate (22 female, 41 male) with either horizontal (n = 38) or vertical incisions (n = 25). Mean interval between trauma and surgery was 3 days (1 to 8 days). Electrodiagnostic tests were performed to 15 @entity1 who felt @entity1183 across their shoulder or chest and ASES test was performed to each of the @entity1 12 weeks postoperatively. IBM SPSS Statistics 22 (IBM SPSS, T  rkiye) programme was used for statistical analysis. Student t-test was used for comparison of normally distributed parameters (quantity) and continuity (yates) test was used. p < 0.05 was accepted to be statistically signifiant. RESULTS 8 @entity1 of the horizontal incision group and 7 @entity1 of the vertical incision group described @entity1183 across their shoulders. 14 @entity1 had abnormal sensorial electrodiagnostic fidings. Comparison of electrodiagnostic fidings did not reveal any statistical signifiance. The mean ASES score of the affected shoulder was 76.39   1.20 in the horizontal group, in the vertical group it was found to be 79.00  2.5 ( p < 0.01). COnCLUSIOnS Electrodiagnostic study revealed similar results in both groups. According to these results, signifiant difference in mean ASES scores of both groups was not related to @entity6784 . Key words: @entity174 , @entity16 .

title: XXXX after Surgical Treatment of @entity174 : Comparison of Two Incisions.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['clavicle fracture', 'clavicular fractures']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['supraclavicular neuropathy']

entities_list: @entity6784 :: ('MESH:D059348', 'Disease') :: ['sensorial injury of the supraclavicular nerve']

answer: @entity16 :: (MESH:D009422,Disease) :: ['Supraclavicular Neuropathy']


abstract: UNASSIGNED: PURPOSE Of THE STUDy To compare the clinical results of @entity174 operated by superior locking plate using either horizontal or vertical incision by physical examination and nerve conduction tests. MATERIAL AnD METHODS Between January 2010 and January 2013, 63 @entity1 with displaced midshaft @entity174 were treated with superior locking plate (22 female, 41 male) with either horizontal (n = 38) or vertical incisions (n = 25). Mean interval between trauma and surgery was 3 days (1 to 8 days). Electrodiagnostic tests were performed to 15 @entity1 who felt @entity1183 across their shoulder or chest and ASES test was performed to each of the @entity1 12 weeks postoperatively. IBM SPSS Statistics 22 (IBM SPSS, T  rkiye) programme was used for statistical analysis. Student t-test was used for comparison of normally distributed parameters (quantity) and continuity (yates) test was used. p < 0.05 was accepted to be statistically signifiant. RESULTS 8 @entity1 of the horizontal incision group and 7 @entity1 of the vertical incision group described @entity1183 across their shoulders. 14 @entity1 had abnormal sensorial electrodiagnostic fidings. Comparison of electrodiagnostic fidings did not reveal any statistical signifiance. The mean ASES score of the affected shoulder was 76.39   1.20 in the horizontal group, in the vertical group it was found to be 79.00  2.5 ( p < 0.01). COnCLUSIOnS Electrodiagnostic study revealed similar results in both groups. According to these results, signifiant difference in mean ASES scores of both groups was not related to @entity6784 . Key words: @entity174 , @entity16 .

title: @entity16 after Surgical Treatment of XXXX : Comparison of Two Incisions.

answer: @entity174 :: (MESH:D050723,Disease) :: ['Clavicular Fractures']


abstract: OBJECTIVE: To determine the optimum time for @entity396 administration to minimize @entity190 during and after elective cesarean delivery. METHODS: A randomized clinical trial was conducted at Mansoura University Hospital, Egypt, between January 1, 2013, and December 31, 2014. Eligible @entity1 had full-term pregnancies, were scheduled to have a cesarean, and had normal fetal heart tracing. @entity1 were randomly allocated into two equal groups using computer-generated tables and sealed opaque envelopes. @entity396 (400 g, given rectally) was given either before (group 1) or after (group 2) surgery. @entity1 , investigators, and data analysts were not masked to group assignment. The primary outcome was @entity190 . RESULTS: A total of 348 @entity1 were included (174 in each group). @entity190 was significantly lower in group 1 than in group 2 (570  240 vs 844  270mL; P<0.001). The frequency of maternal and neonatal adverse events did not differ between the groups. CONCLUSION: Preoperative @entity396 (400 g, given rectally) reduces @entity190 to a greater extent than does postoperative @entity396 during elective cesarean delivery. The frequency of complications was not affected by time of administration.

title: A randomized clinical trial of preoperative versus postoperative XXXX in elective cesarean delivery.

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'Blood loss']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Patients']

entities_list: @entity396 :: ('MESH:D016595', 'Chemical') :: ['Misoprostol', 'misoprostol']

answer: @entity396 :: (MESH:D016595,Chemical) :: ['misoprostol']


abstract: Some properties of a one-stage, chromogenic clotting assay using tissue thromboplastin as an activator are described. The chromogenic assay uses @entity3613 as substrate and estimates @entity556 by the rate of absorbance produced. Under assay conditions, it was observed that the log ( @entity556 or absorbance/min) is linear with time. The linearity appeared to extend from zero @entity556 up to maximum @entity556 concentration for all concentrations of each plasma type examined including factor V and @entity5630 plasmas. Since the linear slope, b, appears to be a measure of the rate of @entity556 production, it was called the @entity14420 ( @entity14420 ). For dilutions of normal plasma log (b) appears to be linearly related to log (plasma concentration) and to log (PT) where PT is the standard one stage clotting time. For plasmas deficient in extrinsic clotting factors, b was linearly related to log (factor concentrations). The chromogenic assay was most sensitive to changes in prothrombin; least sensitive to changes in factor VII; and unaffected by changes in concentration of factors @entity797 and IX. The standard PT was least sensitive to prothrombin and more sensitive to factors X and VII. For oral anticoagulated plasmas log b and log PT were linearly correlated with a regression slope which was more negative than that from normal plasma. From theses results it was concluded that @entity14420 is a chromogenic assay sensitive to all factors in the extrinsic pathway; that @entity14420 might be used as both a screening assay for @entity10281 and a monitoring assay for anticoagulants; and that @entity14420 may be more sensitive than the standard PT to the defects from oral anticoagulation.

title: XXXX activation rate constant: one-stage chromogenic assay for the extrinsic system.

entities_list: @entity5630 :: ('MESH:D005168', 'Disease') :: ['factor VII deficient']

entities_list: @entity14420 :: ('6361', 'Gene') :: ['TARC', 'Thrombin Activation Rate Constant']

entities_list: @entity10281 :: ('MESH:D020920', 'Disease') :: ['extrinsic deficiencies']

answer: @entity556 :: (2147,Gene) :: ['Thrombin']


abstract: BACKGROUND: Rare mutations in the @entity855 -binding cassette (ABC) transporter A3 (ABCA3) gene are associated with neonatal @entity649 ( @entity649 ). The contribution of common single nucleotide polymorphisms (SNPs) to preterm @entity649 differs between ethnicities and remains unclear in Chinese @entity1 . This study evaluated whether common SNPs and consequent haplotypes increase susceptibility to @entity649 in a population of preterm @entity1 from the Guangxi Zhuang Autonomous Region of China. METHODS: Using a tagging SNP (tSNP) strategy and real-time polymerase chain reaction, we genotyped four tSNPs (i.e., @entity71908 , @entity71909 , @entity71910 , and @entity71911 ) and one coding SNP ( @entity71912 ) of the ABCA3 gene in preterm @entity1 with @entity649 (n  =  83) and without @entity649 (n  =  83). We predicted the haplotypes. Minor allele frequencies (MAFs) and haplotype distributions were compared between the two groups. We analyzed correlations between the clinical data and the genotypes. RESULTS: Seven haplotypes existed at a frequency of 0.01 or greater. The haplotype TGGAG was significantly more frequent in @entity649 @entity1 than in non- @entity649 @entity1 (p  =  0.026; odds ratio 3.41; 95% confidence interval 1.088-10.685). The MAF of @entity71911 SNP, a crucial SNP of the haplotype TGGAG located in the transcription factor binding site of ABCA3, was significantly higher in @entity649 @entity1 (p  <  0.05); however, the Bonferroni correction test showed no significant difference (p  >  0.05). No significant correlation existed between the @entity71911 genotypes (AG/GG) and any clinical characteristic (e.g., @entity26 supplementation duration and hospitalization, requirement for ventilation, @entity2107 , and mortality rate). CONCLUSION: The TGGAG haplotype may be a risk factor for @entity649 in preterm @entity1 in this Chinese population. Further study is needed with a larger sample size to verify the association between the @entity71911 SNP and increased risk of @entity649 in preterm @entity1 , and to determine whether @entity71911 can be a reference in further population-based studies of ABCA3.

title: The Haplotype TGGAG in the ABCA3 Gene Increases the Risk of Respiratory Distress Syndrome in Preterm XXXX in Southern China.

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome', 'RDS']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity2107 :: ('MESH:D001997', 'Disease') :: ['bronchopulmonary dysplasia complications']

answer: @entity1 :: (9606,Species) :: ['Infants']


abstract: PURPOSE: @entity2295 is essential for bone regeneration in @entity174 . This study aimed to investigate the microvascular morphology and distribution in the non-injured femur and the neovascularization of the metaphyseal critical size defect in a small animal model of @entity170 . MATERIALS AND METHODS: Female @entity35 (n=7) were ovariectomized (OVX) and received a multideficiency diet. Three months after OVX, a 5mm wedge shaped critical size defect was cut at the distal femoral metaphysis and stabilized with a T-shaped mini-plate. After six weeks, the animals were euthanized, and femora were removed and decalcified for micro-CT measurement of @entity174 . RESULTS: No @entity174 healing was observed along the critical size defects. In the non-injured bone, micro-vessel distribution showed a specific pattern, thereby enabling a differentiation between epi-, meta- and diaphysis. Micro-CT based morphometry revealed a significant reduction of the vascular volume fraction as well as the vascular thickness (p<0.001) in the critical size defect compared to the intact contralateral femur. Blood volume related vascular surface (vascular surface/volume) increased significantly (p<0.001). Connectivity density and tissue volume related vascular surface (vascular surface density) did not change significantly. CONCLUSIONS: Micro-CT based vascular morphometry demonstrated differences between epi-, meta- and diaphysis in the non-injured bone as well as differences between the critical size defect and the non-injured metaphysis. As angiogenesis is a crucial prerequisite that precedes osteogenesis, our results may influence further evaluation of osteoconductive or osteogenic biomaterials in this small animal model of @entity170 .

title: XXXX of osteoporotic metaphyseal bone defects: A morphometric micro-CT study.

entities_list: @entity2295 :: ('MESH:D015861', 'Disease') :: ['Neovascularization']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'fracture neovascularization']

answer: @entity2295 :: (MESH:D015861,Disease) :: ['Neovascularization']


abstract: @entity135 ( @entity135 ) cells are neurons found in the hippocampal formation and connected areas that fire as a function of an animal's directional orientation relative to its environment [1, 2]. They integrate self-motion and environmental sensory information to update directional heading [3]. @entity227 , in particular, exert strong control over the preferred direction of @entity135 cell firing [4]. The @entity135 signal has previously been shown to appear adult-like as early as postnatal day 16 (P16) in the @entity35 pup, just after eye opening and coinciding with the first spontaneous exploration of its environment [5, 6]. In order to determine whether the @entity135 circuit can begin its organization prior to the onset of patterned vision, we recorded from the anterodorsal thalamic nucleus (ADN) and its postsynaptic target in the hippocampal formation, the dorsal pre-subiculum (PrSd), before and after eye opening in pre-weanling @entity35 . We find that @entity135 cells can be recorded at the earliest age sampled (P12), several days before eye opening. However, this early @entity135 signal displays low directional information content and lacks stability both within and across trials. Following eye opening, the @entity135 system matures rapidly, as more cells exhibit directional firing, and the quality and reliability of the directional signal improves dramatically. Cue-rotation experiments show that a prominent visual landmark is able to control @entity135 responses within 24  hr of eye opening. Together, the results suggest that the directional network can be organized independently of visual spatial information while demonstrating the importance of patterned vision for accurate and reliable orientation in space.

title: The Development of the Head Direction System before Eye Opening in the XXXX .

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['Head direction', 'HD']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['Visual landmarks']

answer: @entity35 :: (10116,Species) :: ['Rat']


abstract: Intense alkaline phosphatase (ALPase) activity has been localized in the outer plexiform layer of the developing @entity1573 retina. To elucidate the functional significance of this enzymatic activity, we have injected an ALPase inhibitor, @entity7305 , into @entity735 on either the 13th or 15th day of incubation. The retina was fixed between the 15th and 20th day of incubation and examined by electron microscopy. Levamisole injection on the 13th day caused various morphological alterations in retinal development, including the appearance of solitary photoreceptor cells in the subretinal space as well as folding of both the outer plexiform and outer nuclear layers. Pedicles of photoreceptor cells in the outer plexiform layer displayed rather smooth configurations with a reduced number of invaginations by post-synaptic neurites. The outer plexiform layer was thinned and the neuritic extensions in this layer appeared much less developed than in the control (PBS-injected) retina. Photoreceptor outer segments were seldom observed. Besides these alterations, layers of optic fibers and ganglion cells were also affected, as shown by evidence of degeneration in the ganglion cells and thinning of the nerve-fiber layer. Injection of levamisole into day 15 @entity735 exerted less influence on retinal development, but some photoreceptor cells were still found in the subretinal space. Some of these observations have been reported in the retinas of aged normal animals or in retinas with hereditary or induced @entity1105 . It is suggested that ALPase activity in the outer plexiform layer of the developing @entity1573 retina may be important for the onset of normal development of synapses in the outer plexiform layer and differentiation of the photoreceptor cells.

title: Alterations in the differentiation of XXXX retina caused by an intraocular injection of an alkaline phosphatase inhibitor.

entities_list: @entity1105 :: ('MESH:D058499', 'Disease') :: ['retinal dystrophy']

entities_list: @entity7305 :: ('MESH:D007978', 'Chemical') :: ['levamisole']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['embryonic eyes']

answer: @entity1573 :: (9031,Species) :: ['chick']


abstract: BACKGROUND: We determined the epidemiological characteristics of @entity2929 (EM)-resistant @entity4195 (group A streptococci, GAS) strains isolated from Korea and Japan, using emm genotyping and multilocus sequence typing (MLST). METHODS: Clinical isolates of GAS had been collected from 1992 to 2012 in Korea and from 2004 to 2009 in Japan. EM resistance was determined by the microdilution method, and resistance genotypes were assessed by PCR. The emm genotyping and MLST were performed by DNA sequencing. RESULTS: The emm genotypes and sequence types (STs) were concordant in 143 (85.1%) of 168 EM-resistant GAS strains from Korea. ST36/emm12 (35.1%), @entity18830 /emm28 (22.6%), and ST49/emm75 (16.1%) were the most common types. Most of the ST36 (93.9%) and @entity18830 (95.8%) strains harbored erm(B), whereas strains ST49, ST42, and ST15 contained mef(A). The concordance between emm genotypes and STs was 41 (93.2%) among 44 EM-resistant GAS strains from Japan. ST36/emm12 (34.1%), ST49/emm75 (18.2%), and ST28/emm1 (15.9%) were the major types. ST36 isolates harbored either erm(B) (56.3%) or mef(A) (37.5%), whereas isolates ST28, ST49, and ST38 carried only mef(A). The proportion of erm(B) and mef(A) was 66.1% and 33.3% in Korea and 22.7% and 68.2% in Japan, respectively. CONCLUSIONS: The common STs in Korea and Japan were ST36 and ST49, whereas @entity18830 was present only in Korea and ST28 only in Japan. Genotype erm(B) was predominant in Korea, whereas mef(A) was frequent in Japan. There were differences between Korea and Japan regarding the frequencies of emm genotypes, STs, and EM resistance genes among the EM-resistant GAS.

title: Epidemiological Study of XXXX -Resistant @entity4195 From Korea and Japan by emm Genotyping and Multilocus Sequence Typing.

entities_list: @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin']

entities_list: @entity4195 :: ('1314', 'Species') :: ['Streptococcus pyogenes']

answer: @entity2929 :: (MESH:D004917,Chemical) :: ['Erythromycin']


abstract: BACKGROUND: We determined the epidemiological characteristics of @entity2929 (EM)-resistant @entity4195 (group A streptococci, GAS) strains isolated from Korea and Japan, using emm genotyping and multilocus sequence typing (MLST). METHODS: Clinical isolates of GAS had been collected from 1992 to 2012 in Korea and from 2004 to 2009 in Japan. EM resistance was determined by the microdilution method, and resistance genotypes were assessed by PCR. The emm genotyping and MLST were performed by DNA sequencing. RESULTS: The emm genotypes and sequence types (STs) were concordant in 143 (85.1%) of 168 EM-resistant GAS strains from Korea. ST36/emm12 (35.1%), @entity18830 /emm28 (22.6%), and ST49/emm75 (16.1%) were the most common types. Most of the ST36 (93.9%) and @entity18830 (95.8%) strains harbored erm(B), whereas strains ST49, ST42, and ST15 contained mef(A). The concordance between emm genotypes and STs was 41 (93.2%) among 44 EM-resistant GAS strains from Japan. ST36/emm12 (34.1%), ST49/emm75 (18.2%), and ST28/emm1 (15.9%) were the major types. ST36 isolates harbored either erm(B) (56.3%) or mef(A) (37.5%), whereas isolates ST28, ST49, and ST38 carried only mef(A). The proportion of erm(B) and mef(A) was 66.1% and 33.3% in Korea and 22.7% and 68.2% in Japan, respectively. CONCLUSIONS: The common STs in Korea and Japan were ST36 and ST49, whereas @entity18830 was present only in Korea and ST28 only in Japan. Genotype erm(B) was predominant in Korea, whereas mef(A) was frequent in Japan. There were differences between Korea and Japan regarding the frequencies of emm genotypes, STs, and EM resistance genes among the EM-resistant GAS.

title: Epidemiological Study of @entity2929 -Resistant XXXX From Korea and Japan by emm Genotyping and Multilocus Sequence Typing.

answer: @entity4195 :: (1314,Species) :: ['Streptococcus pyogenes']


abstract: OBJECTIVE: Physical exercise has been consistently documented as a complementary therapy in the treatment of @entity308 . However, despite a higher prevalence among @entity1 compared to @entity1 , the trials developed in @entity1 are scarce. In addition, the optimal dosage of exercise capable of producing benefits that reduce @entity308 remains unclear. This clinical trial is designed to measure the effect of a structured physical exercise program as a complement to antidepressant medication in the treatment of @entity1 with @entity308 . METHODS: From July 2013 to May 2014, we implemented a randomized controlled trial (HAPPY BRAIN study). A total of 26 @entity1 (aged 50.16      12.08) diagnosed with clinical @entity308 were randomized either to a supervised aerobic exercise group (45-50  min/week three times a week for four months) plus pharmacotherapy (intervention group), or only antidepressant medication (control group). RESULTS: The exercise group presented a decrease in BDI-II and DASS-21 total score scales. Relatively to DASS-21, it showed a significant decrease in @entity148 and stress. The exercise group when compared to a control group showed improvement in relation to physical functioning parameters between baseline and post-intervention. Moreover, anthropometric parameters presented only significant differences between groups in fat mass percentage. Nonetheless, no differences were found between groups in weight, body mass index, waist circumference, and self-esteem. CONCLUSION: Our results showed that supervised structured aerobic exercise training could be an effective adjuvant therapy for treating @entity1 with @entity308 , reducing depressive symptomatology and improving physical fitness. A key factor of this improvement included strict control of exercise workload parameters and adjustment to each subject's capacity. In our study, due to the sample size there is an increase in the probability of @entity1605 .

title: Effects of structured exercise and pharmacotherapy vs. pharmacotherapy for adults with XXXX : A randomized clinical trial.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depressive symptoms', 'depression']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['type II errors']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']


abstract: Toxicogenomics is proposed to be a useful tool in @entity1 health risk assessment. However, a systematic comparison of traditional risk assessment approaches with those applying toxicogenomics has never been done. We conducted a case study to evaluate the utility of toxicogenomics in the risk assessment of @entity3014 ( @entity3015 ), a well-studied carcinogen, for drinking water exposures. Our study was intended to compare methodologies, not to evaluate drinking water safety. We compared traditional ( @entity35125 ), genomics-informed ( @entity35126 ) and genomics-only ( @entity40007 ) approaches. @entity35126 and @entity40007 applied toxicogenomics data from @entity1 cell cultures and @entity19 exposed to @entity3015 to determine if these data could provide insight into @entity3015 's mode of action (MOA) and derive tissue-specific points of departure (POD). Our global gene expression analysis supported that @entity3015 is genotoxic in @entity19 and allowed the development of a detailed MOA. Toxicogenomics analysis in @entity1 lymphoblastoid TK6 cells demonstrated a high degree of consistency in perturbed pathways with animal tissues. Quantitatively, the PODs for traditional and transcriptional approaches were similar (liver 1.2 vs. 1.0 mg/kg-bw/day; lungs 0.8 vs. 3.7 mg/kg-bw/day; forestomach 0.5 vs. 7.4 mg/kg-bw/day). @entity40007 , which applied toxicogenomics in the absence of apical toxicology data, demonstrates that this approach provides useful information in data-poor situations. Overall, our study supports the use of toxicogenomics as a relatively fast and cost-effective tool for hazard identification, preliminary evaluation of potential carcinogens, and carcinogenic potency, in addition to identifying current limitations and practical questions for future work.

title: Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in @entity1 health risk assessment of XXXX in drinking water.

entities_list: @entity3014 :: ('MESH:D001564', 'Chemical') :: ['benzo[a]pyrene']

answer: @entity3014 :: (MESH:D001564,Chemical) :: ['benzo[a]pyrene']


abstract: Toxicogenomics is proposed to be a useful tool in @entity1 health risk assessment. However, a systematic comparison of traditional risk assessment approaches with those applying toxicogenomics has never been done. We conducted a case study to evaluate the utility of toxicogenomics in the risk assessment of @entity3014 ( @entity3015 ), a well-studied carcinogen, for drinking water exposures. Our study was intended to compare methodologies, not to evaluate drinking water safety. We compared traditional ( @entity35125 ), genomics-informed ( @entity35126 ) and genomics-only ( @entity40007 ) approaches. @entity35126 and @entity40007 applied toxicogenomics data from @entity1 cell cultures and @entity19 exposed to @entity3015 to determine if these data could provide insight into @entity3015 's mode of action (MOA) and derive tissue-specific points of departure (POD). Our global gene expression analysis supported that @entity3015 is genotoxic in @entity19 and allowed the development of a detailed MOA. Toxicogenomics analysis in @entity1 lymphoblastoid TK6 cells demonstrated a high degree of consistency in perturbed pathways with animal tissues. Quantitatively, the PODs for traditional and transcriptional approaches were similar (liver 1.2 vs. 1.0 mg/kg-bw/day; lungs 0.8 vs. 3.7 mg/kg-bw/day; forestomach 0.5 vs. 7.4 mg/kg-bw/day). @entity40007 , which applied toxicogenomics in the absence of apical toxicology data, demonstrates that this approach provides useful information in data-poor situations. Overall, our study supports the use of toxicogenomics as a relatively fast and cost-effective tool for hazard identification, preliminary evaluation of potential carcinogens, and carcinogenic potency, in addition to identifying current limitations and practical questions for future work.

title: Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in XXXX health risk assessment of @entity3014 in drinking water.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Objectives. This study was conducted to verify the necessity of corresponding prescription to the diagnosed pattern in acute @entity385 @entity1 . Methods. We studied @entity385 @entity1 hospitalized within 30 days after the ictus. Forty-four clinical indicators, @entity894 ( @entity894 ) score, Scandinavian @entity64 Scale (SSS) score, and herbal prescriptions were checked twice, two weeks apart. The probability of each pattern was calculated based on the clinical indicators. Changes in @entity894 score, SSS score, and the probability of fire-heat pattern were compared between the pattern-prescription correspondence group and the noncorrespondence group. Results. Increments of @entity894 score and SSS score in the correspondence group were significantly greater than those of the noncorrespondence group (p = 0.003, p = 0.001) while the baseline score of the two groups showed no significant difference. Probability of fire-heat pattern decreased significantly in the correspondence group (p = 0.013) while the noncorrespondence group showed no significant difference after the treatment. Conclusion. Acute @entity385 @entity1 who are diagnosed as fire-heat pattern showed better improvement in dysfunctions caused by the disease when they took the pattern corresponding prescriptions. This study provides evidence for the necessity and usefulness of pattern identification in Traditional Korean Medicine.

title: Effect of Herbal Prescriptions in Accordance with Pattern Identification in Acute XXXX @entity1 : Based on Fire-Heat Pattern.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity894 :: ('MESH:C566784', 'Disease') :: ['Motricity Index', 'MI']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity385 :: (MESH:D002544,Disease) :: ['Cerebral Infarction']


abstract: Objectives. This study was conducted to verify the necessity of corresponding prescription to the diagnosed pattern in acute @entity385 @entity1 . Methods. We studied @entity385 @entity1 hospitalized within 30 days after the ictus. Forty-four clinical indicators, @entity894 ( @entity894 ) score, Scandinavian @entity64 Scale (SSS) score, and herbal prescriptions were checked twice, two weeks apart. The probability of each pattern was calculated based on the clinical indicators. Changes in @entity894 score, SSS score, and the probability of fire-heat pattern were compared between the pattern-prescription correspondence group and the noncorrespondence group. Results. Increments of @entity894 score and SSS score in the correspondence group were significantly greater than those of the noncorrespondence group (p = 0.003, p = 0.001) while the baseline score of the two groups showed no significant difference. Probability of fire-heat pattern decreased significantly in the correspondence group (p = 0.013) while the noncorrespondence group showed no significant difference after the treatment. Conclusion. Acute @entity385 @entity1 who are diagnosed as fire-heat pattern showed better improvement in dysfunctions caused by the disease when they took the pattern corresponding prescriptions. This study provides evidence for the necessity and usefulness of pattern identification in Traditional Korean Medicine.

title: Effect of Herbal Prescriptions in Accordance with Pattern Identification in Acute @entity385 XXXX : Based on Fire-Heat Pattern.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: @entity751 is a very rare disorder of autosomal recessive inheritance distinguished by @entity27221 and early onset of @entity2521 affecting the dentition. Genetic studies have identified a mutation in the major gene locus of chromosome 11q14 with loss of function. @entity26903 gene is to be responsible for @entity751 . The present case report describes a 13-year-old female, who visited the Department of Periodontology with the chief compliant of bleeding gums and loose teeth. She presented with the signs and symptoms of @entity751 . The @entity1 had premature shedding of her deciduous dentition. On clinical examination, extraorally, the @entity1 presented with persistent thickening, flaking, and scaling of the skin of palms and soles. Her intraoral examination revealed @entity32 , abscess formation, and periodontal pockets. Her intraoral radiographs showed @entity604 involving the central incisors and molars. The @entity1 underwent periodontal therapy and is under maintenance.

title: XXXX : Periodontists' Perspective.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['gingival inflammation']

entities_list: @entity27221 :: ('MESH:C536306', 'Disease') :: ['palmar plantar hyperkeratosis']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['Papillion-Lef  vre Syndrome']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis']

answer: @entity751 :: (MESH:D013577,Disease) :: ['Papillion-Lef  vre Syndrome']


abstract: Objectives. To assess cardiovascular risk factors in Nepalese population with @entity1375 as compared to age and sex matched controls. Materials and Methods. A case control study was conducted among 200 subjects (100 @entity1375 and 100 euthyroid) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. Demographic and anthropometric variables including systolic and diastolic blood pressure (BP) were taken. Blood samples were assayed for serum free @entity1954 (fT3), free @entity1955 (fT4), thyroid stimulating hormone (TSH), total @entity165 (TC), high density lipoprotein @entity165 (HDL-C), low density lipoprotein @entity165 (LDL-C), and high sensitivity @entity1851 (hs-CRP). Results. @entity1375 @entity1 had significantly higher diastolic BP, total @entity165 , LDL @entity165 , and hs-CRP than controls. The odds ratio of having @entity1007 (>200   mg/dL), low HDL @entity165 (<40   mg/dL), undesirable LDL- @entity165 (>100   mg/dL), high hs-CRP (>1 mg/L), and high diastolic BP (>80 mmHg) and being overweight (BMI >=  23   Kg/m(2)) in @entity1375 was 2.29 (95% CI; 1.2-4.38, p = 0.011), 1.73 (95% CI; 0.82-3.62, p = 0.141), 3.04 (95% CI; 1.66-5.56, p < 0.001), 2.02 (95% CI; 1.12-3.64, p = 0.018), 3.35 (95% CI; 1.72-6.55, p < 0.001), and 0.9 (95% CI; 0.48-1.67, p = 0.753), respectively, as compared to controls. Conclusion. @entity1375 @entity1 are associated with higher risk for @entity65 than euthyroid subjects.

title: Cardiovascular Risk Factors in XXXX : A Case Control Study in Nepalese Population.

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism', 'Subclinical hypothyroid', 'subclinical hypothyroid']

entities_list: @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia']

entities_list: @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine']

entities_list: @entity1954 :: ('MESH:D014284', 'Chemical') :: ['triiodothyronine']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C reactive protein']

answer: @entity1375 :: (MESH:D007037,Disease) :: ['Subclinical Hypothyroidism']


abstract: BACKGROUND: Injuries among welders are an important health issue in metal industries at global level. The study aimed to assess the prevalence and pattern of @entity130 and its possible associated risk factors among welders. MATERIALS AND METHODS: A cross-sectional study was conducted among 209 welders in metal industries of Puducherry, @entity3548 India. Data regarding all types of @entity130 during the past 1 year were collected by administering a pre-designed questionnaire. The various risk factors associated with @entity130 that include age, training before induction, experience, job duration, @entity286 chewing, @entity167 use and use of protective measures were assessed using standard questionnaire. The data was analyzed by univariate and multiple logistic regression analysis. RESULTS: Majority of subjects were aged between 20 and 40 years (160, 76.6%) and educated below 10(th) standard (181, 86.6%). Mean number of injury was found to be 10.74 (SD = 5.74) in the preceding year. All of them had more than 2 @entity130 and 44% (92) of them had more than 10 @entity130 . All of them had abrasions and more than three fourths of them had each of lacerations, foreign @entity735 , flash @entity4808 . Multiple logistic regression analysis showed that age less than 30 years (OR = 5.19), @entity286 use (OR = 2.56), @entity167 use (OR = 3.96) and institutional training (OR = 0.10) were the predictors associated with more than 10 @entity130 among welders. CONCLUSION: Injury among welders is an important health problem in this area. Strategies for strengthening institutional training for younger age groups may help in decreasing the burden of @entity130 .

title: Prevalence and pattern of occupational injuries at workplace among welders in XXXX India.

entities_list: @entity3548 :: ('MESH:C538659', 'Disease') :: ['coastal south']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['body in the eye']

entities_list: @entity4808 :: ('MESH:D002056', 'Disease') :: ['burns and contusions']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']

answer: @entity3548 :: (MESH:C538659,Disease) :: ['coastal south']


abstract: OBJECTIVES: To evaluate treatment compliance to weekly concurrent chemoradiotherapy (CRT) in @entity213 ( @entity213 ). STUDY DESIGN: Retrospective analysis. SETTING: Tertiary care hospital. MAIN OUTCOME MEASURES: Overall treatment time (OTT), acute radiation morbidity and treatment completion rate without prolongation of overall treatment time of more than 2 days. RESULTS: Three hundred and seventy-eight @entity135 @entity1 treated with radical CRT with 70 Gy/35 fractions of radiotherapy with weekly @entity900 40 mg/m(2) were included in the study. Median age was 52 years (range 22-77 years), oropharynx was most commonly (54%) involved site, and 55% were in stage IV disease. Majority (86%) of @entity1 were able to complete @entity5 -directed therapy, median OTT was 52 days (46-140 days). Nineteen per cent of @entity1 completed treatment without prolongation of OTT beyond 2 days and 68% of @entity1 there completed treatment prolongation of OTT beyond 7 days. Nearly, sixty-six of the @entity1 experienced grade II or higher acute radiation morbidities. CONCLUSIONS: Delivery of weekly low-dose concurrent CRT is safe and feasible. Two-thirds of the @entity1 experienced treatment prolongation of more than 2 days and 14% could not complete treatment. Results within in the study suggest to a greater need to lay emphasis on continuity of a course of radical CRT for @entity213 .

title: Six-year analysis of compliance to weekly concurrent chemoradiotherapy in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck carcinomas']


abstract: INTRODUCTION: Neonatal @entity649 is closely related to gestational age and mode of birth. Lowest gestational ages and caesarean section are associated with higher risk of developing @entity649 . The efficacy of antenatal @entity288 is well established in the induction of lung maturation in premature births. Its use could be a beneficial intervention in term fetuses that will be born by elective caesarean section. OBJECTIVE: To find the best evidence available to determine whether the use of antenatal @entity288 reduces the incidence of @entity649 in term babies born by elective caesarean section. METHODOLOGY: We searched the available medical literature in different databases: PubMed, LILACS, UpToDate, @entity63819 database, Scielo and Cochrane. We considered controlled, randomized therapeutic studies, performed on @entity1 , in which the intervention included @entity288 as a treatment in elective term cesareans. RESULTS: We selected two studies. In both, the intervention was two doses of 12 mg of @entity619 before the caesarean section. The primary objective in both studies was to analyze the incidence of @entity649 and the admission of the newborn into intensive care units. In both studies, there was less incidence of @entity4837 @entity649 , with statistically significant results. CONCLUSIONS: We concluded that the use of @entity288 in elective term caesarean section reduces the incidence of @entity4837 @entity649 and the admission into intensive care units. However, we evidenced certain weaknesses that could modify the internal validity of both studies, so it is necessary to develop new studies that could support these findings in order to modify clinical protocols in term elective caesarean sections.

title: [Do antenatal XXXX in term elective cesarean sections reduce @entity4837 respiratory morbidity?]

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity288 :: (MESH:D000305,Chemical) :: ['corticosteroids']


abstract: INTRODUCTION: Neonatal @entity649 is closely related to gestational age and mode of birth. Lowest gestational ages and caesarean section are associated with higher risk of developing @entity649 . The efficacy of antenatal @entity288 is well established in the induction of lung maturation in premature births. Its use could be a beneficial intervention in term fetuses that will be born by elective caesarean section. OBJECTIVE: To find the best evidence available to determine whether the use of antenatal @entity288 reduces the incidence of @entity649 in term babies born by elective caesarean section. METHODOLOGY: We searched the available medical literature in different databases: PubMed, LILACS, UpToDate, @entity63819 database, Scielo and Cochrane. We considered controlled, randomized therapeutic studies, performed on @entity1 , in which the intervention included @entity288 as a treatment in elective term cesareans. RESULTS: We selected two studies. In both, the intervention was two doses of 12 mg of @entity619 before the caesarean section. The primary objective in both studies was to analyze the incidence of @entity649 and the admission of the newborn into intensive care units. In both studies, there was less incidence of @entity4837 @entity649 , with statistically significant results. CONCLUSIONS: We concluded that the use of @entity288 in elective term caesarean section reduces the incidence of @entity4837 @entity649 and the admission into intensive care units. However, we evidenced certain weaknesses that could modify the internal validity of both studies, so it is necessary to develop new studies that could support these findings in order to modify clinical protocols in term elective caesarean sections.

title: [Do antenatal @entity288 in term elective cesarean sections reduce XXXX respiratory morbidity?]

answer: @entity4837 :: (MESH:D007567,Disease) :: ['neonatal']


abstract: OBJECTIVE: To assess @entity282 in endodontic therapy and its association with clinical factors such as gender, age, tooth type, pulpal diagnosis, and @entity158 , @entity10193 and sealer extrusion. STUDY DESIGN: Cross-Sectional study. PLACE AND DURATION OF STUDY: Dental section of the Aga khan university hospital, Karachi, Pakistan from January to December 2009. METHODOLOGY: One hundred and forty @entity1 (140) requiring endodontic therapy for @entity2651 were included in this study. Local Anesthesia (2% Lidocain with 1:80,000 Epinephrine) was administered. The tooth was isolated with rubber dam. Access cavity was prepared with the help of round carbide No. 2 bur. Canal preparation was completed using crown-down technique. Access was sealed with sterile dry @entity2708 pallet and restored temporarily with double layer of Glass ionomer cement and Cavit. After one week @entity1 were recalled and access was re-opened, obturation was done using cold lateral condensation technique. Ca(OH)(2) based sealer was used. Postoperative radiographs were taken. @entity1 were recalled after 24 hours and @entity158 was recorded using Visual analogue scale (VAS).Data was obtained on a structured Performa.   (2) test was used for statistical analysis. RESULTS: @entity158 was present in 42.9% of @entity1 . Females more frequently experienced @entity158 (65%) than males (35%). @entity158 was found to be significantly associated with @entity282 (p value < 0.001). Obturation length was not found to be significantly associated with @entity282 (p value 1.0). Sealer extrusion was not found to be significantly associated with postoperative (P value 0.547).

title: Factors associated with XXXX in endodontic therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2651 :: ('MESH:D000848', 'Disease') :: ['molar and premolar teeth']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['postobturation pain', 'Pain', 'pain', 'preoperative pain', 'Preoperative pain']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity10193 :: ('MESH:D006553', 'Disease') :: ['length of obturation']

answer: @entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']


abstract: INTRODUCTION: @entity0 is the most common @entity5 in @entity1 . Unlike IDC, which typically metastasizes to the lung, liver or bone, ILC has been found to metastasize to GI tract, peritoneum and retroperitoneum. Nonspecific symptomology may be considered secondary to other diseases and this can delay the definite diagnosis and treatment of @entity3 . Knowledge of the pattern of disease spread is essential for accurate diagnosis and early initiation of systemic treatment, thus avoiding unnecessary interventions. We are reporting three unique cases of metastatic ILC presenting with wide range of symptoms. CASE PRESENTATIONS: Case A: 69-year-old female presented with recurrent @entity1087 . Case B: 77-year-old female with the past medical history of right breast ILC seven years ago status post right radical mastectomy with chemotherapy, presented with @entity417 . Case C: 56-year-old female presented with bright red blood per rectum. CONCLUSION: A high level of suspicion is needed for metastatic @entity0 in @entity1 with history of ILC, regardless of disease free interval. Since it frequently metastasizes to unusual sites and presents with a wide spectrum of symptoms.

title: Unique presentations of XXXX : a case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast carcinoma', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']

answer: @entity0 :: (MESH:D001943,Disease) :: ['invasive lobular breast cancer']


abstract: The liver is the organ usually affected by metastatic @entity2184 (MUM). Current treatments are almost always ineffective and mortality remains high. In this study, copy number variations (CNVs) were identified in 12 metastatic and five matched primary UMs (PUMs). Our data revealed a wide spectrum of genetic alterations in MUM. Most common were amplifications of chromosome (chr.) 8q; alterations on chr. 3 included monosomy, isodisomy, and large regions of homozygosity (ROH). Genomic profiles of @entity9171 -MUM pairs varied in their degree of similarity and complexity. However, within the pairs, 135 genes were consistently altered. Protein expression of @entity517 and @entity10162 was examined by immunohistochemistry (IHC); a positive association between IHC and CNVs was seen for @entity517 . This comprehensive catalogue of CNVs associated with MUM should facilitate the identification of key alterations that drive @entity5 growth. This would have the potential to select urgently needed novel, targeted, therapeutic regimens.

title: Insights into genetic alterations of liver metastases from XXXX .

entities_list: @entity2184 :: ('MESH:C536494', 'Disease') :: ['uveal melanoma']

answer: @entity2184 :: (MESH:C536494,Disease) :: ['uveal melanoma']


abstract: CONTEXT: @entity5343 ( @entity5343 ) is a life-threatening condition that is often due to monogenic causes in @entity1 . Although @entity774 occurs commonly, several other important molecular causes have been reported, often with overlapping clinical and biochemical features. The relative prevalence of these conditions is not known, but making a specific diagnosis can have important implications for management. OBJECTIVE: The objective of the study was to investigate the clinical and molecular genetic characteristics of a nationwide cohort of @entity1 with @entity5343 of unknown etiology. DESIGN: A structured questionnaire was used to evaluate clinical, biochemical, and imaging data. Genetic analysis was performed using Haloplex capture and next-generation sequencing. @entity1 with @entity774 , @entity8019 , @entity1887 , or obvious syndromic @entity5343 were excluded. SETTING: The study was conducted in 19 tertiary pediatric endocrinology clinics. @entity1 : Ninety-five @entity1 (48 females, aged 0-18 y, eight familial) with @entity5343 of unknown etiology participated in the study. RESULTS: A genetic diagnosis was obtained in 77 @entity1 (81%). The range of etiologies was as follows: @entity4787 (n = 25), @entity2539 (n = 12), @entity624 (n = 11), @entity5986 (n = 9), @entity4788 (n = 9), NNT (n = 7), @entity24382 (n = 2), @entity20043 (n = 1), and @entity20719 (n = 1). Recurrent mutations occurred in several genes, such as @entity71913 in @entity4787 , @entity71914 in @entity5986 , and @entity71915 in @entity4788 . Several important clinical and molecular insights emerged. CONCLUSION: This is the largest nationwide study of the molecular genetics of childhood @entity5343 undertaken. Achieving a molecular diagnosis in more than 80% of @entity1 has important translational impact for counseling families, presymptomatic diagnosis, personalized treatment (eg, mineralocorticoid replacement), predicting comorbidities (eg, neurological, puberty/fertility), and targeting clinical genetic testing in the future.

title: Rare Causes of Primary XXXX : Genetic and Clinical Characterization of a Large Nationwide Cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'PATIENTS']

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['autoimmune adrenal insufficiency']

entities_list: @entity5343 :: ('MESH:D000224', 'Disease') :: ['Primary adrenal insufficiency', 'PAI']

entities_list: @entity71915 :: ('c|DEL|IVS3DS+1|G', 'DNAMutation') :: ['c.IVS3ds+1delG']

entities_list: @entity8019 :: ('MESH:D000326', 'Disease') :: ['adrenoleukodystrophy']

entities_list: @entity774 :: ('MESH:D000312', 'Disease') :: ['congenital adrenal hyperplasia']

answer: @entity1887 :: (MESH:D000309,Disease) :: ['Adrenal Insufficiency']


abstract: UNASSIGNED: @entity1377 ( @entity1377 ) is a rare, underreported, and often misdiagnosed @entity5 of the sweat glands. It is often located on the digits and toes and most commonly occurs in male individuals in their fifties to seventies. Because of lack of @entity158 , slow growth, and an inconspicuous appearance, clinical diagnosis is often missed or delayed. In contrast, @entity19274 ( @entity19274 ) is a cystic @entity652 that arises from the apocrine secretory coil, and it is extremely rare for AHs to develop on the digits. We report 7 cases of @entity1377 , including clinical course, histopathologic and immunohistochemical findings, and therapeutic approach in which the initial histopathologic diagnosis in all cases was @entity19274 or @entity9296 . However, complete excision of the @entity5 led to a final diagnosis of @entity1377 . After an adequate treatment, no recurrence or @entity3 was found in any of the cases described. All the cases studied showed similar histopathologic and immunohistochemical findings. The initial incisional biopsy showed large unilocular or multilocular cystic spaces situated within the dermis, lined by a double layer of epithelial cells with tiny papillary structures. No cellular atypia, @entity39 , or pleomorphism was observed. However, complete excision revealed @entity1313 involving the dermis and/or subcutis, with an infiltrative pattern and papillary projections into luminal spaces. Immunoperoxidase studies showed positivity for @entity5822 , S-100 protein, @entity787 , @entity4206 , smooth muscle actin, and calponin. @entity1377 is a rare but life-threatening malignancy, therefore it is important to be able to identify such a lesion both clinically and histopathologically, treat it, and monitor the @entity1 for the @entity5 's potential recurrence and @entity3 . Pathologists and dermatopathologists should be aware that a histopathologic diagnosis of @entity19274 or @entity9296 on the fingers and toes should be established with caution, because probably those lesions represent the superficial and cystic component of an underlying @entity1377 , and a wider excision should be performed.

title: "Apocrine XXXX and @entity5 : A Potential Diagnostic Pitfall of Digital Papillary Adenocarcinoma.

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['DPC', 'Digital papillary carcinoma']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor', 'neoplasms']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['neoplastic lesions']

entities_list: @entity19274 :: ('MESH:D018251', 'Disease') :: ['apocrine hidrocystoma', 'AH']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity9296 :: ('MESH:D003537', 'Disease') :: ['cystadenoma']

answer: @entity19274 :: (MESH:D018251,Disease) :: ['Hidrocystoma']


abstract: UNASSIGNED: @entity1377 ( @entity1377 ) is a rare, underreported, and often misdiagnosed @entity5 of the sweat glands. It is often located on the digits and toes and most commonly occurs in male individuals in their fifties to seventies. Because of lack of @entity158 , slow growth, and an inconspicuous appearance, clinical diagnosis is often missed or delayed. In contrast, @entity19274 ( @entity19274 ) is a cystic @entity652 that arises from the apocrine secretory coil, and it is extremely rare for AHs to develop on the digits. We report 7 cases of @entity1377 , including clinical course, histopathologic and immunohistochemical findings, and therapeutic approach in which the initial histopathologic diagnosis in all cases was @entity19274 or @entity9296 . However, complete excision of the @entity5 led to a final diagnosis of @entity1377 . After an adequate treatment, no recurrence or @entity3 was found in any of the cases described. All the cases studied showed similar histopathologic and immunohistochemical findings. The initial incisional biopsy showed large unilocular or multilocular cystic spaces situated within the dermis, lined by a double layer of epithelial cells with tiny papillary structures. No cellular atypia, @entity39 , or pleomorphism was observed. However, complete excision revealed @entity1313 involving the dermis and/or subcutis, with an infiltrative pattern and papillary projections into luminal spaces. Immunoperoxidase studies showed positivity for @entity5822 , S-100 protein, @entity787 , @entity4206 , smooth muscle actin, and calponin. @entity1377 is a rare but life-threatening malignancy, therefore it is important to be able to identify such a lesion both clinically and histopathologically, treat it, and monitor the @entity1 for the @entity5 's potential recurrence and @entity3 . Pathologists and dermatopathologists should be aware that a histopathologic diagnosis of @entity19274 or @entity9296 on the fingers and toes should be established with caution, because probably those lesions represent the superficial and cystic component of an underlying @entity1377 , and a wider excision should be performed.

title: "Apocrine @entity19274 and XXXX : A Potential Diagnostic Pitfall of Digital Papillary Adenocarcinoma.

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cystadenoma"-like Tumor of the Digits or Toes']


abstract: UNASSIGNED: Forty entire male @entity1707 from a commercial crossbreed (Duroc * Large White * Landrace) were used to investigate the individual or combined effects of @entity7727 and @entity534 supplementation in Lys-deficient diets on growth performance, carcass traits, and pork quality. @entity1707 with 59.9    1.65 kg BW were randomly assigned to 1 of 5 dietary treatments ( = 8). The 5 dietary treatments were normal Lys and CP diet (0.51% Lys and 16% CP; control), reduced Lys and CP diet (0.35% Lys and 13% CP), reduced Lys and CP diet with @entity7727 supplementation (0.33%), reduced Lys and CP diet with @entity534 supplementation (1.5%), and reduced Lys and CP diet with @entity7727 and @entity534 supplementation (0.33% @entity7727 and 1.5% @entity534 ). @entity1707 were slaughtered at 92.7    2.54 kg BW. The Lys-deficient diets (-35% Lys) increased intramuscular fat (IMF) content by 25% ( = 0.041) and meat juiciness by 12% ( = 0.041) but had a negative effect on growth performance ( < 0.05) of @entity1707 . In addition, Lys-deficient diets increased L* ( = 0.005) and b* ( = 0.010) muscle color parameters and perirenal fat deposition ( < 0.001) and decreased both HCW ( = 0.015) and loin weight ( = 0.023). @entity7727 and @entity534 supplementation of Lys-deficient diets had no effect on IMF content but increased ( < 0.05) overall pork acceptability. @entity369 supplementation also increased ( = 0.003) meat tenderness. Differences in @entity844 composition of pork were not detected among dietary treatment groups. However, @entity3952 was positively correlated ( < 0.05) with IMF content, juiciness, flavor, and overall acceptability of meat. Data confirm that dietary CP reduction enhances pork eating quality but negatively affects @entity1707 ' growth performance. Moreover, it is suggested that @entity7727 and @entity534 supplementation of Lys-deficient diets does not further increase IMF content but improves some pork sensory traits, including overall acceptability.

title: Effect of XXXX and @entity369 in lysine-deficient diets on growth, carcass traits, and pork quality.

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity3952 :: ('MESH:D019301', 'Chemical') :: ['oleic acid']

entities_list: @entity7727 :: ('MESH:D001622', 'Chemical') :: ['betaine', 'Betaine']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['Arginine']

answer: @entity7727 :: (MESH:D001622,Chemical) :: ['betaine']


abstract: UNASSIGNED: Forty entire male @entity1707 from a commercial crossbreed (Duroc * Large White * Landrace) were used to investigate the individual or combined effects of @entity7727 and @entity534 supplementation in Lys-deficient diets on growth performance, carcass traits, and pork quality. @entity1707 with 59.9    1.65 kg BW were randomly assigned to 1 of 5 dietary treatments ( = 8). The 5 dietary treatments were normal Lys and CP diet (0.51% Lys and 16% CP; control), reduced Lys and CP diet (0.35% Lys and 13% CP), reduced Lys and CP diet with @entity7727 supplementation (0.33%), reduced Lys and CP diet with @entity534 supplementation (1.5%), and reduced Lys and CP diet with @entity7727 and @entity534 supplementation (0.33% @entity7727 and 1.5% @entity534 ). @entity1707 were slaughtered at 92.7    2.54 kg BW. The Lys-deficient diets (-35% Lys) increased intramuscular fat (IMF) content by 25% ( = 0.041) and meat juiciness by 12% ( = 0.041) but had a negative effect on growth performance ( < 0.05) of @entity1707 . In addition, Lys-deficient diets increased L* ( = 0.005) and b* ( = 0.010) muscle color parameters and perirenal fat deposition ( < 0.001) and decreased both HCW ( = 0.015) and loin weight ( = 0.023). @entity7727 and @entity534 supplementation of Lys-deficient diets had no effect on IMF content but increased ( < 0.05) overall pork acceptability. @entity369 supplementation also increased ( = 0.003) meat tenderness. Differences in @entity844 composition of pork were not detected among dietary treatment groups. However, @entity3952 was positively correlated ( < 0.05) with IMF content, juiciness, flavor, and overall acceptability of meat. Data confirm that dietary CP reduction enhances pork eating quality but negatively affects @entity1707 ' growth performance. Moreover, it is suggested that @entity7727 and @entity534 supplementation of Lys-deficient diets does not further increase IMF content but improves some pork sensory traits, including overall acceptability.

title: Effect of @entity7727 and XXXX in lysine-deficient diets on growth, carcass traits, and pork quality.

answer: @entity369 :: (CHEBI:29016,Chemical) :: ['arginine']


abstract: UNASSIGNED: This study investigated effects of stocking rate on @entity291 performance, quality and quantity of @entity4336 residue, and impact of residue removal on grain yield for 5 yr at the University of Nebraska - Lincoln West Central Water Resources Field Laboratory near Brule, NE. Four removal treatments-1) no removal (control), 2) grazing at 2.5 animal unit month (AUM)/ha, 3) grazing at 5.0 AUM/ha, and 4) baling-were applied to a center pivot-irrigated @entity4336 field (53 ha). The field was divided into eight 6.6-ha paddocks to which replicated treatments were assigned. Samples of residue were collected in October and March (before and after residue removal) using ten 0.5-m quadrats per treatment replication. Residue was separated into 5 plant parts-stem, cob, leaf, husk, and grain-and analyzed for nutrient content. Esophageally fistulated @entity291 were used to measure diet quality. @entity291 assigned to the 2.5 AUM/ha stocking rate treatment gained more BW ( < 0.01) and BCS ( < 0.01) than @entity291 assigned to the 5.0 AUM/ha treatment. Leaf contained the most ( < 0.01) CP and husk had the greatest ( < 0.01) @entity2402 ( @entity2402 ) but the CP and @entity2402 of individual plant parts did not differ ( > 0.69) between sampling dates. Amount of total residue was reduced ( < 0.05) by baling and both grazing treatments between October and March but was not different ( > 0.05) in control paddocks between sampling dates. As a proportion of the total residue, stem increased ( < 0.01) and husk decreased ( < 0.01) between October and March. Diet CP content was similar ( = 0.10) between sampling dates for the 2 grazing treatments but @entity2402 was greater after grazing in the 2.5 AUM/ha grazing treatment ( = 0.04). Subsequent grain yields were not different ( = 0.16) across all 4 residue removal treatments. At the proper stocking rate, @entity4336 residue grazing results in acceptable animal performance without negatively impacting subsequent @entity4336 grain production.

title: @entity4336 residue stocking rate affects XXXX performance but not subsequent grain yield.

entities_list: @entity2402 :: ('MESH:D010015', 'Disease') :: ['in vitro OM disappearance', 'IVOMD']

answer: @entity291 :: (9913,Species) :: ['cattle']


abstract: UNASSIGNED: This study investigated effects of stocking rate on @entity291 performance, quality and quantity of @entity4336 residue, and impact of residue removal on grain yield for 5 yr at the University of Nebraska - Lincoln West Central Water Resources Field Laboratory near Brule, NE. Four removal treatments-1) no removal (control), 2) grazing at 2.5 animal unit month (AUM)/ha, 3) grazing at 5.0 AUM/ha, and 4) baling-were applied to a center pivot-irrigated @entity4336 field (53 ha). The field was divided into eight 6.6-ha paddocks to which replicated treatments were assigned. Samples of residue were collected in October and March (before and after residue removal) using ten 0.5-m quadrats per treatment replication. Residue was separated into 5 plant parts-stem, cob, leaf, husk, and grain-and analyzed for nutrient content. Esophageally fistulated @entity291 were used to measure diet quality. @entity291 assigned to the 2.5 AUM/ha stocking rate treatment gained more BW ( < 0.01) and BCS ( < 0.01) than @entity291 assigned to the 5.0 AUM/ha treatment. Leaf contained the most ( < 0.01) CP and husk had the greatest ( < 0.01) @entity2402 ( @entity2402 ) but the CP and @entity2402 of individual plant parts did not differ ( > 0.69) between sampling dates. Amount of total residue was reduced ( < 0.05) by baling and both grazing treatments between October and March but was not different ( > 0.05) in control paddocks between sampling dates. As a proportion of the total residue, stem increased ( < 0.01) and husk decreased ( < 0.01) between October and March. Diet CP content was similar ( = 0.10) between sampling dates for the 2 grazing treatments but @entity2402 was greater after grazing in the 2.5 AUM/ha grazing treatment ( = 0.04). Subsequent grain yields were not different ( = 0.16) across all 4 residue removal treatments. At the proper stocking rate, @entity4336 residue grazing results in acceptable animal performance without negatively impacting subsequent @entity4336 grain production.

title: XXXX residue stocking rate affects @entity291 performance but not subsequent grain yield.

answer: @entity4336 :: (381124,Species) :: ['Corn']


abstract: BACKGROUND: Given the clinical practice of prescribing physical rehabilitation for the treatment of @entity121 , the present study examined the functional and histomorphological adaptations in the volumetric muscle loss (VML) injured muscle to physical rehabilitation. METHODS: Tibialis anterior muscle VML injury was created in Lewis @entity35 (n   =   32), and were randomly assigned to either sedentary (SED) or physical rehabilitation (RUN) group. After 1  week, RUN @entity35 were given unlimited access to @entity2798 wheels either 1 or 7  weeks (2 or 8  weeks @entity130 ). At 2  weeks @entity130 , TA muscles were harvested for molecular analyses. At 8  weeks @entity130 , the @entity35 underwent in vivo function testing. The explanted tissue was analyzed using histological and immunofluorescence procedures. RESULTS: The primary findings of the study are that physical rehabilitation in the form of @entity2798 promotes   ~   17% improvement in maximal isometric torque, and a   ~   13% increase in weight of the injured muscle, but it did so without significant morphological adaptations (e.g., no @entity1184 and @entity1373 ). Wheel running up-regulated metabolic genes ( @entity19310 , @entity6229 ) only in the uninjured muscles, and a greater deposition of fibrous tissue in the defect area of the injured muscle preceded by an up-regulation of pro-fibrotic genes (Collagen I, @entity1810 ). Therefore, it is plausible that the wheel running related functional improvements were due to improved force transmission and not muscle regeneration. CONCLUSIONS: This is the first study to demonstrate improvement in functional performance of non-repaired VML injured muscle with physical rehabilitation in the form of @entity2798 . This study provides information for the first time on the basic changes in the VML injured muscle with physical rehabilitation, which may aid in the development of appropriate physical rehabilitation regimen(s).

title: Physical rehabilitation improves muscle function following volumetric XXXX .

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['VML injuries']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['post-injury']

entities_list: @entity2798 :: ('MESH:D009155', 'Disease') :: ['voluntary running', 'voluntary wheel running']

answer: @entity121 :: (MESH:D009135,Disease) :: ['muscle loss injury']


abstract: UNASSIGNED: Botulinum neurotoxins (BoNTs) are highly potent bacterial proteins that block neurotransmitter release at the neuromuscular junction by cleaving SNAREs (soluble @entity8816 sensitive factor attachment protein receptors). However, their serotype A (BoNT/A) that cleaves @entity12252 ( @entity12252 ) has also been an established pharmaceutical for treatment of medical conditions that rely on hyperactivity of cholinergic nerve terminals for 25years. The expansion of its use to a variety of further medical conditions associated with hypersecretion components is prevented partly because the involved SNARE isoforms are not cleaved. Therefore, we examined by mutational analyses the reason for the resistance of @entity1 @entity24835 , an isoform of @entity12252 . We show that replacement of 10 @entity24835 residues with their @entity12252 counterparts effects @entity12252 -like cleavability. Conversely, transfer of each of the replaced @entity24835 residues to @entity12252 drastically decreased the cleavability of @entity12252 . By means of the existing @entity12252 -toxin co-crystal structure, molecular dynamics simulations, and corroborative mutagenesis studies, the appropriate binding pockets for these residues in BoNT/A were characterized. Systematic mutagenesis of two major BoNT/A binding pockets was conducted in order to adapt these pockets to corresponding @entity3534 of @entity1 @entity24835 . @entity1 @entity24835 cleaving mutants were isolated using a newly established @entity375 -based screening system. This method may be useful for engineering novel BoNT/A pharmaceuticals for the treatment of diseases that rely on @entity24835 -mediated hypersecretion.

title: Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for @entity1 XXXX .

entities_list: @entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids']

entities_list: @entity8816 :: ('MESH:D005033', 'Chemical') :: ['N-ethyl maleimide']

entities_list: @entity12252 :: ('6616', 'Gene') :: ['SNAP-25', 'synaptosomal-associated protein of 25kDa']

answer: @entity24835 :: (8773,Gene) :: ['SNAP-23']


abstract: UNASSIGNED: Botulinum neurotoxins (BoNTs) are highly potent bacterial proteins that block neurotransmitter release at the neuromuscular junction by cleaving SNAREs (soluble @entity8816 sensitive factor attachment protein receptors). However, their serotype A (BoNT/A) that cleaves @entity12252 ( @entity12252 ) has also been an established pharmaceutical for treatment of medical conditions that rely on hyperactivity of cholinergic nerve terminals for 25years. The expansion of its use to a variety of further medical conditions associated with hypersecretion components is prevented partly because the involved SNARE isoforms are not cleaved. Therefore, we examined by mutational analyses the reason for the resistance of @entity1 @entity24835 , an isoform of @entity12252 . We show that replacement of 10 @entity24835 residues with their @entity12252 counterparts effects @entity12252 -like cleavability. Conversely, transfer of each of the replaced @entity24835 residues to @entity12252 drastically decreased the cleavability of @entity12252 . By means of the existing @entity12252 -toxin co-crystal structure, molecular dynamics simulations, and corroborative mutagenesis studies, the appropriate binding pockets for these residues in BoNT/A were characterized. Systematic mutagenesis of two major BoNT/A binding pockets was conducted in order to adapt these pockets to corresponding @entity3534 of @entity1 @entity24835 . @entity1 @entity24835 cleaving mutants were isolated using a newly established @entity375 -based screening system. This method may be useful for engineering novel BoNT/A pharmaceuticals for the treatment of diseases that rely on @entity24835 -mediated hypersecretion.

title: Identification and Characterization of Botulinum Neurotoxin A Substrate Binding Pockets and Their Re-Engineering for XXXX @entity24835 .

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: Emergency department treatment and disposition of tricyclic antidepressant ( @entity2974 )- @entity1445 @entity1 remains a common and difficult problem. Various clinical findings have been proposed as @entity137 indicators. To study the performance of QRS duration as a predictor of @entity137 in our @entity1 population, we retrospectively reviewed the cases of all @entity1 presenting to our @entity2613 with @entity2974 overdosage. The charts of 102 @entity1 with quantitative or qualitative laboratory confirmation of @entity2974 ingestion were reviewed for @entity2613 findings and hospital course with specific attention to the occurrence of @entity943 ( @entity943 ) or @entity410 . The @entity2613 ECG revealed that 57 @entity1 had a maximal 12-lead ECG QRS interval duration (QRS) of less than .10 seconds (Group 1). The remaining 45 @entity1 had QRS greater than or equal to .10 seconds (Group 2). Three @entity1 (5%) in Group 1 and three (6%) in Group 2 experienced @entity943 . Four @entity1 (7%) in Group 1 and five (11%) in Group 2 experienced @entity410 . There was no significant difference in the rate of occurrence of @entity943 or @entity410 between the two groups. Of note was the fact that five of eight @entity943 and nine of 11 @entity410 occurred in the @entity2613 setting. We conclude that determination of QRS duration is not an accurate indicator of VA or @entity410 risk for all @entity2974 - @entity1445 populations. In particular, risk of toxic events during the emergency phase of @entity2974 @entity1445 does not appear to be indicated by evaluation of the QRS duration in the @entity2613 .

title: QRS interval in tricyclic antidepressant overdosage: inaccuracy as a XXXX indicator in emergency settings.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'VAs']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']