abstract: PURPOSE: To investigate the performance of a new device that uses the STRATA polytetrafluoroethylene graft material and a mechanism that provides active proximal sealing in order to prevent @entity1070 during @entity439 repair (EVAR). METHODS: Between April 2013 and July 2014, 21 consecutive @entity1 (all @entity1 ; median age 71 years, range 60-84 years) with @entity1028 (median diameter 5.9 cm, range 4.9-7.8 cm) and suitable anatomy were offered elective EVAR using the AFX endograft. These @entity1 had an irregular, conical, tapered, or bulging proximal neck, for which this specific device was considered appropriate. @entity439 exclusion and incidence of @entity1070 were the primary outcomes; secondary outcomes included mortality, morbidity, migration, and other graft-related complications. RESULTS: Primary technical success was 90%; 2 intraoperative type Ia endoleaks due to low endograft deployment were treated with additional proximal cuffs. During a median follow-up of 10 months (range 2-15 months), no @entity1070 was observed. One @entity1070 was encountered, with no associated sac enlargement. There was no stent-graft migration or any other device-related complication. One @entity1 had a nonfatal @entity583 and another developed @entity177 requiring transient dialysis. No @entity204 occurred. CONCLUSION: In this early experience, this newly available device appears to be safe and efficient in providing seal along irregularly shaped necks over the short term.

title: Active proximal sealing in the endovascular repair of XXXX : early results with a new stent-graft.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity1070 :: ('MESH:D057867', 'Disease') :: ['type I endoleak', 'type Ia endoleak', 'type II endoleak']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['endovascular aneurysm', 'Aneurysm']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysms']


abstract: BACKGROUND: There is evidence that both @entity0 @entity1 and their partners are affected emotionally, when facing a @entity0 . Several couple interventions have been evaluated, but there is a need for couple intervention studies with a clear theoretical basis and a strong design. The Hand in Hand intervention is designed to enhance interdependent coping in the couples and to address @entity1 and partners that are both initially distressed and non-distressed. METHODS: The Hand in Hand study is a randomised controlled trial among 199 @entity0 @entity1 and their partners. Couples were randomised to 4-8 couple sessions with a psychologist in addition to usual care, or to usual care only, approximately 2 months after the @entity1 ' primary surgery date. The intervention was delivered within 3 months, and outcomes were assessed prior to randomisation and 5 and 10 months after primary surgery date. The primary outcome is @entity1 ' @entity5 at the 5-month follow-up measured by the Impact of Event Scale. Secondary outcomes are assessed for both @entity0 @entity1 and partners. These outcomes are: general distress, symptoms of @entity148 and @entity308 , health-related quality of life and measures of dyadic adjustment, intimacy and partner involvement. @entity5 is also assessed for partners. Eligible @entity1 were @entity1   >=    18 years newly diagnosed with primary @entity0 , cohabiting with a male partner, having no previous @entity5 diagnoses, receiving no neo-adjuvant treatment, having no history of hospitalisation due to @entity716 , and able to read and speak Danish. Partners were eligible if they could read and speak Danish and were   >=    18 years. DISCUSSION: This study investigates the effect of an attachment-oriented psychological intervention for @entity0 @entity1 and their partners. The intervention has a theoretical framework and a strong design. If proven effective, this intervention would be helpful in optimising psychosocial care and rehabilitation of couples coping with @entity0 . TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01368380.

title: Attachment-oriented psychological intervention for couples facing XXXX : protocol of a randomised controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer diagnosis', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer-specific distress', 'cancer', 'cancer-specific distress']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: OBJECTIVE: Using a retrospective cohort study, the mean length of hospital stay (LoS) and total per- @entity1 expenditure for @entity4053 requiring admission to hospital were estimated. In a separate matched retrospective cohort study, the effect of inpatient @entity4053 on LoS, expenditure, and risk of all-cause mortality while admitted was investigated. METHODS: The cohorts consisted of @entity1 aged >= 18   years with a diagnosis of @entity164 1 or 2 @entity6 between January 1, 2002 and October 30, 2012 in the Clinical Practice Research Datalink database, who had initiated insulin treatment and had a recording of @entity4053 in the same period. In the matched retrospective cohort study, exposed @entity1 (who experienced @entity4053 in hospital) were case-matched with @entity1 who did not experience @entity4053 during admission (unexposed). Generalized linear regression was used to estimate LoS. Risk of all-cause mortality was evaluated via logistic regression. RESULTS: In the retrospective cohort study (1131 @entity1 ), mean LoS was 5.46 (95% CI 4.62  to 6.45) days for @entity164 1 @entity6 , and 5.04 (95% CI 4.46 to 5.71) days for @entity164 2 @entity6 . Mean cost per admission was   1034 (95% CI   855 to   1253). In the matched retrospective cohort study (1079 pairs of @entity1 ), exposed @entity1 had a mean LoS of 11.91   days (95% CI 10.96  to 12.94   days) versus 4.80 (95% CI 4.41  to 5.23) for unexposed @entity1 , p<0.0001. Exposed @entity1 had a higher mortality risk compared with unexposed @entity1 (OR 1.439 (95% CI 1.060to 1.952), p=0.0195). Total average per- @entity1 cost for exposed @entity1 was GBP (  )2235, 40% (p<0.0001) higher than total average admission cost in unexposed @entity1 . CONCLUSIONS: @entity4053 has a significant negative impact on @entity1 outcomes, healthcare resource use, and expenditure.

title: Healthcare resource implications of XXXX -related hospital admissions and inpatient @entity4053 : retrospective record-linked cohort studies in England.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['Hypoglycemia', 'hypoglycemia']

answer: @entity4053 :: (MESH:D007003,Disease) :: ['hypoglycemia']


abstract: OBJECTIVE: Using a retrospective cohort study, the mean length of hospital stay (LoS) and total per- @entity1 expenditure for @entity4053 requiring admission to hospital were estimated. In a separate matched retrospective cohort study, the effect of inpatient @entity4053 on LoS, expenditure, and risk of all-cause mortality while admitted was investigated. METHODS: The cohorts consisted of @entity1 aged >= 18   years with a diagnosis of @entity164 1 or 2 @entity6 between January 1, 2002 and October 30, 2012 in the Clinical Practice Research Datalink database, who had initiated insulin treatment and had a recording of @entity4053 in the same period. In the matched retrospective cohort study, exposed @entity1 (who experienced @entity4053 in hospital) were case-matched with @entity1 who did not experience @entity4053 during admission (unexposed). Generalized linear regression was used to estimate LoS. Risk of all-cause mortality was evaluated via logistic regression. RESULTS: In the retrospective cohort study (1131 @entity1 ), mean LoS was 5.46 (95% CI 4.62  to 6.45) days for @entity164 1 @entity6 , and 5.04 (95% CI 4.46 to 5.71) days for @entity164 2 @entity6 . Mean cost per admission was   1034 (95% CI   855 to   1253). In the matched retrospective cohort study (1079 pairs of @entity1 ), exposed @entity1 had a mean LoS of 11.91   days (95% CI 10.96  to 12.94   days) versus 4.80 (95% CI 4.41  to 5.23) for unexposed @entity1 , p<0.0001. Exposed @entity1 had a higher mortality risk compared with unexposed @entity1 (OR 1.439 (95% CI 1.060to 1.952), p=0.0195). Total average per- @entity1 cost for exposed @entity1 was GBP (  )2235, 40% (p<0.0001) higher than total average admission cost in unexposed @entity1 . CONCLUSIONS: @entity4053 has a significant negative impact on @entity1 outcomes, healthcare resource use, and expenditure.

title: Healthcare resource implications of @entity4053 -related hospital admissions and inpatient XXXX : retrospective record-linked cohort studies in England.

answer: @entity4053 :: (MESH:D007003,Disease) :: ['hypoglycemia']


abstract: In conscious @entity95 peripheral cold stimuli decreased respiratory rate and increased cutaneous vasomotor tone while simultaneously renal sympathetic nervous discharge decreased. Peripheral warm stimuli produced the reverse pattern of autonomic effector activity. Injection of a bacterial endotoxin at warm ambient temperature elicited a biphasic @entity221 response. Within the first 60 min cutaneous vasomotor tone increased, simultaneously renal sympathetic activity decreased. Therefore, ear skin vessels dilated and renal sympathetic activity increased by about 100%. Respiratory rate remained @entity308 during both @entity221 phases. Renal blood flow was investigated in a second series of experiments and showed a negative stimulation but only in the first phase of @entity221 . The results show that renal innervation is involved in the typical thermoregulatory autonomic activity pattern by which temperature homeostasis is preserved. The vasomotor patterns of cold and heat stress developing during @entity221 are compatible with the concept of a changed set-point of the body thermostat. The @entity308 respiratory rate and the lack of the renal vascular response to the increased nervous activity during the second @entity221 phase and their reversal to normal after @entity1281 ( @entity1281 ) indicate the participation of prostaglandins modifying peripheral and central neurotransmitter mechanisms.

title: Renal and cutaneous vasomotor and respiratory rate adjustments to peripheral cold and warm stimuli and to bacterial endotoxin in conscious XXXX .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed']

entities_list: @entity1281 :: ('CHEBI:15365', 'Chemical') :: ['acetylsalicylate', 'ASA']

answer: @entity95 :: (9986,Species) :: ['rabbits']


abstract: @entity2760 ( @entity2760 ) is a common inflammatory disease in elderly @entity1 . We present a case of a 49-year-old @entity1 diagnosed with @entity2760 . The treatment with @entity229 resulted in a rapid resolution of clinical symptoms. However, inflammatory markers remained elevated. Ultrasonography and computed tomography revealed the presence of a large @entity75 . A cyst was suspected but, because of the high risk of @entity9440 , a splenectomy was performed. The histopathological examination revealed the presence of @entity1074 . Inflammatory markers returned to normal after splenectomy. @entity229 was tapered but clinical symptoms of @entity2760 reappeared after lowering the dose of @entity229 <10 mg/day. Thus, treatment with @entity1499 was started, which allowed for further tapering of @entity229 .

title: @entity2760 in a @entity1 with XXXX - a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'people']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['splenic lesion']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['Prednisone', 'prednisone']

entities_list: @entity1074 :: ('MESH:D018442', 'Disease') :: ['splenic marginal zone lymphoma']

entities_list: @entity2760 :: ('MESH:D011111', 'Disease') :: ['Polymyalgia rheumatica', 'PMR']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity9440 :: ('MESH:D013161', 'Disease') :: ['splenic rupture']

answer: @entity1074 :: (MESH:D018442,Disease) :: ['splenic marginal zone lymphoma']


abstract: @entity2760 ( @entity2760 ) is a common inflammatory disease in elderly @entity1 . We present a case of a 49-year-old @entity1 diagnosed with @entity2760 . The treatment with @entity229 resulted in a rapid resolution of clinical symptoms. However, inflammatory markers remained elevated. Ultrasonography and computed tomography revealed the presence of a large @entity75 . A cyst was suspected but, because of the high risk of @entity9440 , a splenectomy was performed. The histopathological examination revealed the presence of @entity1074 . Inflammatory markers returned to normal after splenectomy. @entity229 was tapered but clinical symptoms of @entity2760 reappeared after lowering the dose of @entity229 <10 mg/day. Thus, treatment with @entity1499 was started, which allowed for further tapering of @entity229 .

title: XXXX in a @entity1 with @entity1074 - a case report.

answer: @entity2760 :: (MESH:D011111,Disease) :: ['Polymyalgia rheumatica']


abstract: @entity2760 ( @entity2760 ) is a common inflammatory disease in elderly @entity1 . We present a case of a 49-year-old @entity1 diagnosed with @entity2760 . The treatment with @entity229 resulted in a rapid resolution of clinical symptoms. However, inflammatory markers remained elevated. Ultrasonography and computed tomography revealed the presence of a large @entity75 . A cyst was suspected but, because of the high risk of @entity9440 , a splenectomy was performed. The histopathological examination revealed the presence of @entity1074 . Inflammatory markers returned to normal after splenectomy. @entity229 was tapered but clinical symptoms of @entity2760 reappeared after lowering the dose of @entity229 <10 mg/day. Thus, treatment with @entity1499 was started, which allowed for further tapering of @entity229 .

title: @entity2760 in a XXXX with @entity1074 - a case report.

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: BACKGROUND: Erythrasma is a superficial @entity272 caused by Corynebacterium minutissimum . @entity34783 is the most common form and is easily confused with @entity14654 . The aim of this study was to determine the prevalence of @entity34783 in @entity1 with clinically suspected @entity14654 . METHODS: This study was performed between January 1, 2011, and January 31, 2012. It included 182 @entity1 who presented with concerns about @entity75 . All of the @entity1 were examined with a Wood's lamp, and smears were stained with Gram's method. Direct examination with 20% @entity4014 was performed. RESULTS: Of 182 @entity1 with @entity75 , 73 (40.1%) were diagnosed as having @entity34783 . The mean    SD age of the @entity1 with @entity34783 was 45.52    10.83 years (range, 22-70 years). Most of the @entity1 with @entity34783 were @entity1 (56.2%). The most often clinical finding was desquamation. Using only Wood's lamp examination or Gram's staining resulted in 31 (42.5%) or 14 (19.2%) positive @entity1 , respectively. Using Wood's lamp examination and Gram's staining concurrently resulted in 28 positive @entity1 (38.4%). CONCLUSIONS: @entity34783 is a common condition and can be difficult to differentiate from @entity14654 . Simple and rapid diagnosis can be made with Wood's lamp examination, but Gram's staining is also a useful method, especially in @entity1 with negative Wood's lamp examination findings.

title: The prevalence of XXXX : a prospective study from an outpatient clinic in Turkey.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity14654 :: ('MESH:D014008', 'Disease') :: ['tinea pedis']

entities_list: @entity4014 :: ('MESH:C029943', 'Chemical') :: ['potassium hydroxide']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['interdigital lesions']

entities_list: @entity34783 :: ('MESH:D004894', 'Disease') :: ['interdigital erythrasma', 'Interdigital erythrasma', 'erythrasma']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin infection']

answer: @entity34783 :: (MESH:D004894,Disease) :: ['interdigital erythrasma']


abstract: Management of @entity0 includes systematic therapies including chemotherapy and endocrine therapy can lead to a variety of symptoms that can impair the quality of life of many @entity0 survivors. @entity3941 , caused by decreased levels of circulating @entity172 to urinary and vaginal receptors, is commonly experienced by this group. Chemotherapy induced @entity2670 and endocrine therapies including aromatase inhibitors and selective @entity172 receptor modulators can trigger the onset of @entity3941 or exacerbate existing symptoms. Symptoms of @entity3941 include @entity2133 , @entity546 , and irritation of genital skin, @entity111 , burning, vaginal discharge, and soreness. The diagnosis of @entity3941 is confirmed through @entity1 -reported symptoms and gynecological examination of external structures, @entity5932 . Lifestyle modifications can be helpful but are usually insufficient to significantly improve symptoms. Non-hormonal vaginal therapies may provide additional relief by increasing vaginal moisture and fluid. Systemic @entity172 therapy is contraindicated in @entity0 survivors. Continued investigations of various treatments for @entity3941 are necessary. Local @entity172 -based therapies, @entity2494 , @entity251 , and pH-balanced gels continue to be evaluated in ongoing studies. Definitive results are needed pertaining to the safety of topical @entity172 in @entity0 survivors.

title: @entity3941 in XXXX survivors: a difficult survivorship issue.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['vaginal dryness']

entities_list: @entity5932 :: ('MESH:C565008', 'Disease') :: ['introitus, and vaginal mucosa']

entities_list: @entity3941 :: ('MESH:D059268', 'Disease') :: ['Atrophic vaginitis', 'atrophic vaginitis']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian failure']

entities_list: @entity546 :: ('MESH:D004414', 'Disease') :: ['dyspareunia']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: Management of @entity0 includes systematic therapies including chemotherapy and endocrine therapy can lead to a variety of symptoms that can impair the quality of life of many @entity0 survivors. @entity3941 , caused by decreased levels of circulating @entity172 to urinary and vaginal receptors, is commonly experienced by this group. Chemotherapy induced @entity2670 and endocrine therapies including aromatase inhibitors and selective @entity172 receptor modulators can trigger the onset of @entity3941 or exacerbate existing symptoms. Symptoms of @entity3941 include @entity2133 , @entity546 , and irritation of genital skin, @entity111 , burning, vaginal discharge, and soreness. The diagnosis of @entity3941 is confirmed through @entity1 -reported symptoms and gynecological examination of external structures, @entity5932 . Lifestyle modifications can be helpful but are usually insufficient to significantly improve symptoms. Non-hormonal vaginal therapies may provide additional relief by increasing vaginal moisture and fluid. Systemic @entity172 therapy is contraindicated in @entity0 survivors. Continued investigations of various treatments for @entity3941 are necessary. Local @entity172 -based therapies, @entity2494 , @entity251 , and pH-balanced gels continue to be evaluated in ongoing studies. Definitive results are needed pertaining to the safety of topical @entity172 in @entity0 survivors.

title: XXXX in @entity0 survivors: a difficult survivorship issue.

answer: @entity3941 :: (MESH:D059268,Disease) :: ['Atrophic vaginitis']


abstract: OBJECTIVE: To determine the prognostic CT and MR imaging features of extranodal @entity1893 in the head and neck region. METHODS: The clinical data and CT and MR imaging features of 59 @entity1 with histologically confirmed extranodal @entity1893 in the head and neck region were retrospectively reviewed. Subjects included 27 male and 32 female @entity1 between 13 and 81  years of age, with a mean age of 60.3  years. The clinical outcomes were categorized according to whether relapse or @entity3 occurred within 2  years after therapy. The association between the clinical outcome and radiologic factors including @entity5 size, margin, shape, @entity5 invasiveness, regional lymph node involvement, number of involvement sites, and contrast enhancement patterns was determined using univariate and multiple logistic regression analysis. RESULTS: Radiologic factors including @entity5 size, margin, shape, and @entity5 invasiveness were associated with poor clinical outcomes, as determined by univariate analysis (P   <   0.05). Only the lesion margin category (ill-defined) remained an independent risk factor for clinical outcome in multivariate logistic regression analysis, with an OR of 8.14 (P   <   0.05). CONCLUSION: Ill-defined margin of the @entity75 was indicative of unfavourable survival outcome for @entity1 with extranodal @entity1893 of the head and neck region. KEY POINTS:     @entity5 size, margin, shape and @entity5 invasiveness were prognostically relevant.     @entity5 margin was an independent risk factor for clinical outcome.     Ill-defined margin of @entity75 was indicative of unfavourable survival outcome.

title: Prognostic CT and MR imaging features in @entity1 with untreated extranodal XXXX of the head and neck region.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['local tumour', 'Tumour', 'tumour']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma']

answer: @entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin lymphoma']


abstract: OBJECTIVE: To determine the prognostic CT and MR imaging features of extranodal @entity1893 in the head and neck region. METHODS: The clinical data and CT and MR imaging features of 59 @entity1 with histologically confirmed extranodal @entity1893 in the head and neck region were retrospectively reviewed. Subjects included 27 male and 32 female @entity1 between 13 and 81  years of age, with a mean age of 60.3  years. The clinical outcomes were categorized according to whether relapse or @entity3 occurred within 2  years after therapy. The association between the clinical outcome and radiologic factors including @entity5 size, margin, shape, @entity5 invasiveness, regional lymph node involvement, number of involvement sites, and contrast enhancement patterns was determined using univariate and multiple logistic regression analysis. RESULTS: Radiologic factors including @entity5 size, margin, shape, and @entity5 invasiveness were associated with poor clinical outcomes, as determined by univariate analysis (P   <   0.05). Only the lesion margin category (ill-defined) remained an independent risk factor for clinical outcome in multivariate logistic regression analysis, with an OR of 8.14 (P   <   0.05). CONCLUSION: Ill-defined margin of the @entity75 was indicative of unfavourable survival outcome for @entity1 with extranodal @entity1893 of the head and neck region. KEY POINTS:     @entity5 size, margin, shape and @entity5 invasiveness were prognostically relevant.     @entity5 margin was an independent risk factor for clinical outcome.     Ill-defined margin of @entity75 was indicative of unfavourable survival outcome.

title: Prognostic CT and MR imaging features in XXXX with untreated extranodal @entity1893 of the head and neck region.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Ocular @entity566 is a common disease in daily practice. OBJECTIVES: A cross-sectional study was conducted to evaluate clinical aspects of and therapeutic approaches to @entity566 in Italy. METHODS: Of the 3685 @entity1 affected by @entity566 and enrolled by 304 ophthalmologists nationally, 3545 were eligible to be included in the statistical analysis. A questionnaire was administered in-office to record demographic data, co-morbidities, trigger factors, number of @entity2024 episodes and past treatments. Signs and symptoms were graded according to their severity, frequency and duration. RESULTS: Mean age of enrolled @entity1 was 38  19 years. @entity56 (55% of @entity1 ) was equally distributed among the different age groups, while @entity56 (18%) increased with age and @entity5902 (9%) was more frequent under the age of 18. Itching and redness were reported in 90% and 85%, respectively; lid skin involvement was observed in 22% of cases, and @entity1036 in 11%. Pollen sensitivities were indicated as the most frequent triggers, however, exposure to non-specific environmental conditions, pollutants and cigarette smoke was frequently reported. Only 35% of @entity1 underwent a diagnostic evaluation of specific allergic sensitization, with positive @entity566 tests found in 82% of this subset. With regard to treatment, topical decongestants were used in 43% of @entity1 , corticosteroids in 41%, antihistamines in 29%, systemic antihistamines in 27%, and mast cell stabilizers in 15%. CONCLUSION: This survey provided useful epidemiological information regarding the clinical characteristics and treatment options of a large cohort of @entity1 affected by different forms of @entity566 . CLINICAL RELEVANCE: An understanding of @entity56 , its incidence, demographics and treatment paradigms, provides important information towards understanding its pharmacoeconomics and burden on the national health system. This article is protected by copyright. All rights reserved.

title: XXXX : a cross-sectional study.

entities_list: @entity1036 :: ('MESH:D007634', 'Disease') :: ['keratitis']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'ocular allergy']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['perennial allergic conjunctivitis', 'Seasonal allergic conjunctivitis', 'ocular allergic disease']

entities_list: @entity2024 :: ('MESH:D003231', 'Disease') :: ['conjunctivitis']

entities_list: @entity5902 :: ('MESH:D003233', 'Disease') :: ['vernal keratoconjunctivitis']

answer: @entity56 :: (MESH:D004342,Disease) :: ['Allergic conjunctivitis']


abstract: BACKGROUND: Plant @entity3150 (PSs) lower LDL @entity165 , an established risk factor for @entity453 ( @entity453 ). No direct evidence is available supporting a reduced risk of @entity453 for foods with added PSs. @entity409 is seen as an early indicator of @entity731 . OBJECTIVES: This study was primarily designed to investigate the effect of a low-fat spread with added PSs on brachial artery endothelial function as measured by @entity384 ( @entity384 ). Second, effects on arterial stiffness, blood pressure, serum lipids, and plasma PS concentrations were investigated. We hypothesized that PSs would not worsen @entity384 but would rather modestly improve @entity384 . DESIGN: This study had a double-blind, randomized, placebo-controlled, parallel design. After a 4-wk run-in period, 240 @entity753 but otherwise healthy @entity1 and @entity1 consumed 20 g/d of low-fat spread without (control) or with added PSs (3 g/d) during 12 wk. Pre- and postintervention, vascular function measurements and blood sampling were performed. RESULTS: In total, 232 @entity1 completed the study period. For the primary endpoint @entity384 , 199 @entity1 were included in the statistical analysis. PS intake did not affect @entity384 (+0.01 percentage points; 95% CI: -0.73, 0.75) compared with control. Measures of arterial stiffness (pulse wave velocity and augmentation index) and blood pressure were also not significantly changed compared with control. After PS intervention, LDL @entity165 significantly decreased on average by 0.26 mmol/L (95% CI: -0.40, -0.12) or 6.7% compared with control. Plasma @entity9542 and @entity9543 concentrations significantly increased in the PS group up to on average 11.5  mol/L and 13.9  mol/L (expressed as geometric means), respectively. CONCLUSIONS: The intake of a low-fat spread with added PSs neither improved nor worsened @entity384 or other vascular function markers in @entity753 @entity1 and @entity1 . As expected, serum LDL @entity165 decreased, whereas plasma PSs increased after PS intake. This study was registered at clinicaltrials.gov as NCT01803178.

title: The effect of a low-fat spread with added plant sterols on vascular function markers: results of the Investigating Vascular Function Effects of Plant XXXX (INVEST) study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity9542 :: ('MESH:C025473', 'Chemical') :: ['sitosterol']

entities_list: @entity753 :: ('OMIM:143890', 'Disease') :: ['hypercholesterolemic']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic damage']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['flow-mediated dilation', 'FMD']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['Endothelial dysfunction']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity9543 :: ('MESH:C021273', 'Chemical') :: ['campesterol']

answer: @entity3150 :: (MESH:D013261,Chemical) :: ['Sterols']


abstract: UNASSIGNED: While PCR is the most common method used for detecting @entity7320 in the US, most laboratories use insertion sequence 481 (IS481), which is not specific for @entity7320 ; therefore, the relative contribution of other @entity34168 species is not understood. The objectives of this study were to evaluate the proportion of other @entity34168 spp. misidentified as @entity7320 during a period of increased pertussis incidence, determine the level of agreement in @entity34168 species detection between US commercial laboratories and CDC, and assess the relative diagnostic sensitivity of CDC's PCR assay when using a different PCR master mix. Specimens collected between May 2012-2013 were tested at two US commercial laboratories for @entity7320 and @entity34168 detection. Every fifth specimen positive for IS481 and/or IS1001 with Ct values  <=35 was sent to CDC for PCR testing that identifies @entity34168 species. Specimens with CDC PCR indeterminate or negative results were tested using an alternate PCR master mix. Of 755 specimens, there was agreement in species identification for 83.4% (n=630). Of those with different identifications (n=125), 79.2% (n=99) were identified as indeterminate @entity7320 at CDC. Overall, 0.66% (n=5) of the specimens were identified as B. holmesii or @entity12024 at CDC. Of 115 specimens with indeterminate or negative results, 46.1% (n=53) were @entity7320 positive when tested by an alternate master mix, suggesting possible increase in assay sensitivity. This study demonstrates good agreement between the two US commercial laboratories and CDC and little misidentification of @entity34168 species during the 2012 US epidemic.

title: An evaluation of the level of agreement in XXXX species identification in three United States laboratories during a period of increased pertussis.

entities_list: @entity7320 :: ('520', 'Species') :: ['Bordetella pertussis', 'B. pertussis']

entities_list: @entity12024 :: ('518', 'Species') :: ['B. bronchiseptica']

entities_list: @entity34168 :: ('519', 'Species') :: ['Bordetella', 'B. parapertussis']

answer: @entity34168 :: (519,Species) :: ['Bordetella']


abstract: OBJECTIVES: @entity10353 ( @entity10353 ) is a rare @entity5 entity, and the most common onset is in the @entity135 region ( @entity10353 -HN). The data on diagnosis, treatment, and especially risk assessment concerning disease course and outcome are @entity942 . This study aimed to evaluate risk factors for local relapse (LR) and lymph node @entity3 (LNM) and their impact on progression-free survival (PFS). MATERIALS AND METHODS: In a retrospective monocentric study, @entity1 with @entity10353 -HN treated between 1999 and 2011 were analyzed regarding clinical and histologic characteristics. Prognostic parameters for LR, LNM, and PFS were evaluated. In total, 89 @entity1 (55 male, 34 female, mean age of 71.8 years) with a mean follow-up time of 47.7 months (range 12-112) were included. RESULTS: LR occurred in four @entity1 (4.5%), LNM occurred in five @entity1 (5.6%). @entity1 with LNM had a significantly shorter PFS time (16.1 months) compared with @entity1 without LNM (154.2 months; P < .001). @entity5 depth and size (T classification), incomplete resection, localization at the ear, deep maximal vertical infiltration, muscle and vessel invasion all showed significant (P < .05) associations with LR, LNM, and shorter PFS time. @entity10353 showed more histologic features of @entity1491 ( @entity1491 ), especially with regard to BerEP4 expression. CONCLUSION: While histology shows some typical characteristics of @entity1491 , the biologic behavior and aggressiveness of @entity10353 are similar to those of @entity957 . This is the first study to show that LR and, especially, LNM indicate a higher risk of an unfavorable outcome.

title: XXXX of the @entity135 : clinical and histologic characteristics and their impact on disease progression.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['cutaneous squamous cell carcinoma']

entities_list: @entity1491 :: ('MESH:D002280', 'Disease') :: ['basal cell carcinoma', 'BCC']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity10353 :: ('MESH:D002281', 'Disease') :: ['BSC', 'Basosquamous carcinoma']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['deficient or inconsistent']

answer: @entity10353 :: (MESH:D002281,Disease) :: ['Basosquamous carcinoma']


abstract: OBJECTIVES: @entity10353 ( @entity10353 ) is a rare @entity5 entity, and the most common onset is in the @entity135 region ( @entity10353 -HN). The data on diagnosis, treatment, and especially risk assessment concerning disease course and outcome are @entity942 . This study aimed to evaluate risk factors for local relapse (LR) and lymph node @entity3 (LNM) and their impact on progression-free survival (PFS). MATERIALS AND METHODS: In a retrospective monocentric study, @entity1 with @entity10353 -HN treated between 1999 and 2011 were analyzed regarding clinical and histologic characteristics. Prognostic parameters for LR, LNM, and PFS were evaluated. In total, 89 @entity1 (55 male, 34 female, mean age of 71.8 years) with a mean follow-up time of 47.7 months (range 12-112) were included. RESULTS: LR occurred in four @entity1 (4.5%), LNM occurred in five @entity1 (5.6%). @entity1 with LNM had a significantly shorter PFS time (16.1 months) compared with @entity1 without LNM (154.2 months; P < .001). @entity5 depth and size (T classification), incomplete resection, localization at the ear, deep maximal vertical infiltration, muscle and vessel invasion all showed significant (P < .05) associations with LR, LNM, and shorter PFS time. @entity10353 showed more histologic features of @entity1491 ( @entity1491 ), especially with regard to BerEP4 expression. CONCLUSION: While histology shows some typical characteristics of @entity1491 , the biologic behavior and aggressiveness of @entity10353 are similar to those of @entity957 . This is the first study to show that LR and, especially, LNM indicate a higher risk of an unfavorable outcome.

title: @entity10353 of the XXXX : clinical and histologic characteristics and their impact on disease progression.

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck']


abstract: Eight @entity1 with @entity2758 (AVMs) underwent staged transcatheter @entity1416 . Six @entity1 had AVMs involving an extremity, one had multiple pulmonary AVMs, and one had an AVM of the pancreas. Embolization was performed using Ivalon ( @entity4832 ) particles and Gianturco coils. Clinical course, fever pattern, and appropriate enzymatic laboratory studies were monitored. @entity491 occurred in all but one @entity1 following embolization. A febrile course with the temperature reaching 39.6 degrees C without evidence of @entity281 was seen in several @entity1 for 3 to 5 days postembolization. Marked elevation in the @entity908 phosphokinase level and positive fibrin split products were noted in several instances. Because embolizations were performed in stages, serial arteriography was available. Embolization resulted in a reduction in symptoms in all eight @entity1 and allowed a more limited surgical procedure than would otherwise have been possible in two @entity1 . Complications occurred in three @entity1 and are described. It is concluded that transcatheter @entity1416 is a useful therapeutic alternative in the management of congenital AVMs.

title: Embolization therapy in the management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2758 :: ('MESH:D001165', 'Disease') :: ['congenital arteriovenous malformations']

entities_list: @entity4832 :: ('MESH:D011142', 'Chemical') :: ['polyvinyl alcohol']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolization']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity491 :: ('MESH:D007964', 'Disease') :: ['Leukocytosis']

answer: @entity2758 :: (MESH:D001165,Disease) :: ['congenital arteriovenous malformations']


abstract: OBJECTIVE: Activation of @entity23710 ( @entity23710 ) inhibits @entity731 but induces @entity2298 . In vitro, it has been shown that @entity8838 ( @entity8838 ) inhibitor synergizes @entity23710 ligand-induced macrophage @entity23711 expression and @entity165 efflux. In this study, we determined whether @entity8838 ( @entity5732 ) and @entity23710 ligand ( @entity18340 ) can have a synergistic effect on the reduction of @entity731 while eliminating @entity23710 ligand-induced @entity1560 and @entity2298 . We also set out to identify the cellular mechanisms of the actions. APPROACH AND RESULTS: Wild-type @entity19 were used to determine the effect of @entity5732 on a high-fat diet or high-fat diet plus @entity18340 -induced @entity2299 and @entity99 . @entity6970 deficient ( @entity6970 (-/-)) @entity19 or @entity19 with advanced lesions were used to determine the effect of the combination of @entity18340 and @entity5732 on @entity731 and @entity2298 . We found that @entity5732 protected animals against @entity18340 -induced transient or long-term hepatic lipid accumulation, @entity99 , and @entity2298 . Meanwhile, the combination of @entity18340 and @entity5732 inhibited the development of @entity731 in a synergistic manner and @entity75 . Mechanistically, in addition to synergistic induction of macrophage @entity23711 expression, the combination of @entity5732 and @entity18340 maintained arterial wall integrity, inhibited macrophage accumulation in aortas and formation of macrophages/foam cells, and activated reverse @entity165 transport. The inhibition of @entity18340 -induced lipid accumulation by the combined @entity5732 might be attributed to inactivation of lipogenesis and activation of lipolysis/ @entity844 oxidation pathways. CONCLUSIONS: Our study suggests that the combination of @entity8838 inhibitor and @entity23710 ligand can function as a novel therapy to synergistically reduce @entity731 while eliminating @entity23710 -induced deleterious effects.

title: Inhibition of ERK1/2 and Activation of XXXX Synergistically Reduce Atherosclerotic Lesions in @entity6970 -Deficient @entity19 .

entities_list: @entity2298 :: ('MESH:D015228', 'Disease') :: ['hypertriglyceridemia']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty livers']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['transient dyslipidemia']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['reduced advanced lesions']

entities_list: @entity8838 :: ('26395;26396', 'Gene') :: ['mitogen-activated protein kinase kinase 1/2', 'MEK1/2']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity23710 :: (22259(Tax:10090),Gene) :: ['LXR']


abstract: OBJECTIVE: Activation of @entity23710 ( @entity23710 ) inhibits @entity731 but induces @entity2298 . In vitro, it has been shown that @entity8838 ( @entity8838 ) inhibitor synergizes @entity23710 ligand-induced macrophage @entity23711 expression and @entity165 efflux. In this study, we determined whether @entity8838 ( @entity5732 ) and @entity23710 ligand ( @entity18340 ) can have a synergistic effect on the reduction of @entity731 while eliminating @entity23710 ligand-induced @entity1560 and @entity2298 . We also set out to identify the cellular mechanisms of the actions. APPROACH AND RESULTS: Wild-type @entity19 were used to determine the effect of @entity5732 on a high-fat diet or high-fat diet plus @entity18340 -induced @entity2299 and @entity99 . @entity6970 deficient ( @entity6970 (-/-)) @entity19 or @entity19 with advanced lesions were used to determine the effect of the combination of @entity18340 and @entity5732 on @entity731 and @entity2298 . We found that @entity5732 protected animals against @entity18340 -induced transient or long-term hepatic lipid accumulation, @entity99 , and @entity2298 . Meanwhile, the combination of @entity18340 and @entity5732 inhibited the development of @entity731 in a synergistic manner and @entity75 . Mechanistically, in addition to synergistic induction of macrophage @entity23711 expression, the combination of @entity5732 and @entity18340 maintained arterial wall integrity, inhibited macrophage accumulation in aortas and formation of macrophages/foam cells, and activated reverse @entity165 transport. The inhibition of @entity18340 -induced lipid accumulation by the combined @entity5732 might be attributed to inactivation of lipogenesis and activation of lipolysis/ @entity844 oxidation pathways. CONCLUSIONS: Our study suggests that the combination of @entity8838 inhibitor and @entity23710 ligand can function as a novel therapy to synergistically reduce @entity731 while eliminating @entity23710 -induced deleterious effects.

title: Inhibition of ERK1/2 and Activation of @entity23710 Synergistically Reduce Atherosclerotic Lesions in XXXX -Deficient @entity19 .

answer: @entity6970 :: (11816(Tax:10090),Gene) :: ['ApoE']


abstract: OBJECTIVE: Activation of @entity23710 ( @entity23710 ) inhibits @entity731 but induces @entity2298 . In vitro, it has been shown that @entity8838 ( @entity8838 ) inhibitor synergizes @entity23710 ligand-induced macrophage @entity23711 expression and @entity165 efflux. In this study, we determined whether @entity8838 ( @entity5732 ) and @entity23710 ligand ( @entity18340 ) can have a synergistic effect on the reduction of @entity731 while eliminating @entity23710 ligand-induced @entity1560 and @entity2298 . We also set out to identify the cellular mechanisms of the actions. APPROACH AND RESULTS: Wild-type @entity19 were used to determine the effect of @entity5732 on a high-fat diet or high-fat diet plus @entity18340 -induced @entity2299 and @entity99 . @entity6970 deficient ( @entity6970 (-/-)) @entity19 or @entity19 with advanced lesions were used to determine the effect of the combination of @entity18340 and @entity5732 on @entity731 and @entity2298 . We found that @entity5732 protected animals against @entity18340 -induced transient or long-term hepatic lipid accumulation, @entity99 , and @entity2298 . Meanwhile, the combination of @entity18340 and @entity5732 inhibited the development of @entity731 in a synergistic manner and @entity75 . Mechanistically, in addition to synergistic induction of macrophage @entity23711 expression, the combination of @entity5732 and @entity18340 maintained arterial wall integrity, inhibited macrophage accumulation in aortas and formation of macrophages/foam cells, and activated reverse @entity165 transport. The inhibition of @entity18340 -induced lipid accumulation by the combined @entity5732 might be attributed to inactivation of lipogenesis and activation of lipolysis/ @entity844 oxidation pathways. CONCLUSIONS: Our study suggests that the combination of @entity8838 inhibitor and @entity23710 ligand can function as a novel therapy to synergistically reduce @entity731 while eliminating @entity23710 -induced deleterious effects.

title: Inhibition of ERK1/2 and Activation of @entity23710 Synergistically Reduce Atherosclerotic Lesions in @entity6970 -Deficient XXXX .

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: OBJECTIVE: To ascertain the existence of discordance between perceived and measured balance in @entity1 with @entity64 and to examine the impact on walking speed and falls. DESIGN: A secondary analysis of a phase three, multicentered randomized controlled trial examining walking recovery following @entity64 . SUBJECTS: A total of 352 @entity1 from the Locomotor Experience Applied Post- @entity64 (LEAPS) trial. METHODS: @entity1 were categorized into four groups: two concordant and two discordant groups in relation to measured and perceived balance. Number and percentage of individuals with concordance and discordance were evaluated at two and 12 months. Walking speed and fall incidence between groups were examined. MAIN MEASURES: Perceived balance was measured by the Activities-Specific Balance Confidence scale, measured balance was determined by the Berg Balance Scale and gait speed was measured by the 10-meter walk test. RESULTS: Discordance was present for 35.8% of @entity1 at two months @entity64 with no statistically significant change in proportion at 12   months. Discordant @entity1 with high perceived balance and low measured balance walked 0.09   m/s faster at two months than @entity1 with concordant low perceived and measured balance (p   <   0.05). Discordant @entity1 with low perceived balance and high measured balance walked 0.15   m/s slower than those that were concordant with high perceived and measured balance (p         0.0001) at 12   months. Concordant @entity1 with high perceived and measured balance walked fastest and had fewer falls. CONCLUSIONS: Discordance existed between perceived and measured balance in one-third of individuals at two and 12   months post- @entity64 . Perceived balance impacted gait speed but not fall incidence.

title: Concordance and discordance between measured and perceived balance and the effect on gait speed and falls following XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'persons']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['post stroke', 'stroke', 'Stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: UNASSIGNED: Chemotherapy is a mainstay of therapy for advanced @entity356 ( @entity356 ); however, owing to drug resistances, the effectiveness of chemotherapy is not satisfactory for some @entity1 with @entity356 . Therefore, identification of a marker that predicts treatment response is beneficial to @entity1 . Hypermethylation of transcription factor activating enhancer-binding protein 2    ( @entity71281 ) has been implicated in chemotherapy resistance to fluorouracil-based chemotherapy in @entity1 with @entity14 , but its role in @entity356 is still unknown. In this study, we investigated @entity71281 as a predictor of treatment response in @entity356 . We used methylation-sensitive high-resolution melting analysis to study the methylation of @entity71281 in 141 @entity356 tissue specimens and 45 adjacent nontumor tissue specimens. In vitro experiments, we analyzed the expression and methylation of @entity71281 and to examine the sensitivity of @entity356 cell lines to 5-fluorouracil (5-FU). The @entity71281 methylation occurred at a significantly higher incidence rate in @entity5 tissues compared to adjacent nontumor tissues (chi-square [  (2)] = 38.919, P < .001). Hypermethylation of @entity71281 occurred more frequently in @entity5 with lower differentiation grades (P < .001) and was significantly associated with nonresponse to fluorouracil-based chemotherapy (P = .010). Hypermethylation was also associated with decreased expression of @entity71281 (P < .01) and nonresponse to 5-FU exposure in vitro (P < .001). Hypermethylation of @entity71281 was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in @entity1 with @entity356 .

title: Transcription Factor AP2   : A Potential Predictor of Chemoresistance in @entity1 With XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'GC']

answer: @entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']


abstract: UNASSIGNED: Chemotherapy is a mainstay of therapy for advanced @entity356 ( @entity356 ); however, owing to drug resistances, the effectiveness of chemotherapy is not satisfactory for some @entity1 with @entity356 . Therefore, identification of a marker that predicts treatment response is beneficial to @entity1 . Hypermethylation of transcription factor activating enhancer-binding protein 2    ( @entity71281 ) has been implicated in chemotherapy resistance to fluorouracil-based chemotherapy in @entity1 with @entity14 , but its role in @entity356 is still unknown. In this study, we investigated @entity71281 as a predictor of treatment response in @entity356 . We used methylation-sensitive high-resolution melting analysis to study the methylation of @entity71281 in 141 @entity356 tissue specimens and 45 adjacent nontumor tissue specimens. In vitro experiments, we analyzed the expression and methylation of @entity71281 and to examine the sensitivity of @entity356 cell lines to 5-fluorouracil (5-FU). The @entity71281 methylation occurred at a significantly higher incidence rate in @entity5 tissues compared to adjacent nontumor tissues (chi-square [  (2)] = 38.919, P < .001). Hypermethylation of @entity71281 occurred more frequently in @entity5 with lower differentiation grades (P < .001) and was significantly associated with nonresponse to fluorouracil-based chemotherapy (P = .010). Hypermethylation was also associated with decreased expression of @entity71281 (P < .01) and nonresponse to 5-FU exposure in vitro (P < .001). Hypermethylation of @entity71281 was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in @entity1 with @entity356 .

title: Transcription Factor AP2   : A Potential Predictor of Chemoresistance in XXXX With @entity356 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Within the hippocampus, different kinds of spatial experience determine the direction of change of synaptic weights. Synaptic plasticity resulting from such experience may enable memory encoding. The @entity1251 region is very striking in this regard: due to the distinct molecular properties of the @entity28802 ( @entity28802 ) and associational-commissural (AC) synapses, it is believed that they enable working memory and pattern completion. The question arises, however, as to how information reaching these synapses results in differentiated encoding. Given its crucial role in enabling persistent synaptic plasticity in other hippocampal subfields, we speculated that the metabotropic @entity2227 receptor mGlu5 may regulate information encoding at @entity28802 and AC synapses. Here, we show that antagonism of mGlu5 inhibits LTP, but not LTD at @entity28802 synapses of freely behaving adult @entity35 . Conversely, mGlu5 antagonism prevents LTD but not LTP at AC- @entity1251 synapses. This suggests that, under conditions in which mGlu5 is activated, LTP may be preferentially induced at @entity28802 synapses, whereas LTD is favored at AC synapses. To assess this possibility, we applied 50 Hz stimulation that should generate postsynaptic activity that corresponds to   m, the activation threshold that lies between LTP and LTD. MGlu5 activation had no effect on AC responses but potentiated @entity28802 synapses. These data suggest that mGlu5 serves as a switch that alters signal-to-noise ratios during information encoding in the @entity1251 region. This mechanism supports highly tuned and differentiated information storage in @entity1251 synapses.

title: mGlu5 Acts As a Switch for Opposing Forms of Synaptic Plasticity at Mossy Fiber- XXXX and Commissural Associational- @entity1251 Synapses.

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

answer: @entity1251 :: (54232(Tax:10116),Gene) :: ['CA3']


abstract: Within the hippocampus, different kinds of spatial experience determine the direction of change of synaptic weights. Synaptic plasticity resulting from such experience may enable memory encoding. The @entity1251 region is very striking in this regard: due to the distinct molecular properties of the @entity28802 ( @entity28802 ) and associational-commissural (AC) synapses, it is believed that they enable working memory and pattern completion. The question arises, however, as to how information reaching these synapses results in differentiated encoding. Given its crucial role in enabling persistent synaptic plasticity in other hippocampal subfields, we speculated that the metabotropic @entity2227 receptor mGlu5 may regulate information encoding at @entity28802 and AC synapses. Here, we show that antagonism of mGlu5 inhibits LTP, but not LTD at @entity28802 synapses of freely behaving adult @entity35 . Conversely, mGlu5 antagonism prevents LTD but not LTP at AC- @entity1251 synapses. This suggests that, under conditions in which mGlu5 is activated, LTP may be preferentially induced at @entity28802 synapses, whereas LTD is favored at AC synapses. To assess this possibility, we applied 50 Hz stimulation that should generate postsynaptic activity that corresponds to   m, the activation threshold that lies between LTP and LTD. MGlu5 activation had no effect on AC responses but potentiated @entity28802 synapses. These data suggest that mGlu5 serves as a switch that alters signal-to-noise ratios during information encoding in the @entity1251 region. This mechanism supports highly tuned and differentiated information storage in @entity1251 synapses.

title: mGlu5 Acts As a Switch for Opposing Forms of Synaptic Plasticity at Mossy Fiber- @entity1251 and Commissural Associational- XXXX Synapses.

answer: @entity1251 :: (54232(Tax:10116),Gene) :: ['CA3']


abstract: CONTEXT: @entity1 with advanced @entity43 have a poor prognosis in spite of the best possible care. Primary debulking surgery has been the standard of care in advanced @entity43 ; however, it is associated with high mortality and morbidity rates as shown in various studies. Several studies have discussed the benefit of neoadjuvant chemotherapy in @entity1 with advanced @entity43 . AIMS: This study aims to evaluate the survival statistics of the @entity1 who have been managed with interval debulking surgery (IDS) from January 2007 to December 2009. MATERIALS AND METHODS: During the period from January 2007 to December 2009, a retrospective analysis of 104 @entity1 who underwent IDS for stage IIIC or IV @entity43 at our institute were selected for the study. IDS was attempted after three to five courses of chemotherapy with paclitaxal (175 mg/m(2) ) and @entity3003 (5-6 of area under curve). @entity1349 ( @entity1349 ) and progression free survival (PFS) were compared with results of primary debulking study from existing literature. @entity1349 and PFS rates were estimated by means of the Kaplan-Meier method. Results were statistically analyzed by IBM SPSS Statistics 19. RESULTS: The median @entity1349 was 26 months and the median PFS was 18 months. In multivariate analysis it was found that both @entity1349 and PFS was affected by the stage, and extent of debulking. CONCLUSIONS: Neoadjuvant chemotherapy, followed by surgical cytoreduction is a promising treatment strategy for the management of @entity43 .

title: Neoadjuvant chemotherapy in XXXX : A survival study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['advanced epithelial ovarian cancer', 'ovarian cancer', 'advanced epithelial ovarian cancers']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival']

answer: @entity43 :: (MESH:D010051,Disease) :: ['advanced epithelial ovarian cancer']


abstract: BACKGROUND: Relative to other aspects of Down syndrome, remarkably little is known about the @entity146 problems experienced by youth and young adults with this syndrome and if these problems differ from others with @entity717 . Yet adolescence and young adulthood are particularly vulnerable time periods, as they involve multiple life transitions in educational, medical, and other service systems. METHODS: This study compared the @entity146 diagnoses of 49 adolescent and young adult @entity1 with Down syndrome to 70 @entity1 with other @entity717 ( @entity717 ). The groups were similar in age, gender, and level of @entity73 . The 119 @entity1 , aged 13 to 29  years (M   =   21) were evaluated in one of two specialized @entity146 clinics. RESULTS: In contrast to previous literature, those with Down syndrome versus other @entity717 had significantly higher rates of @entity716 NOS or @entity308 with @entity716 features (43% versus 13%). Unlike the ID group, @entity716 was predominantly seen in females with Down syndrome. Marked motoric slowing in performing routine daily activities or in expressive language was manifested in 17% of @entity1 with Down syndrome. No group differences were found in @entity148 or @entity308 , and the ID group had significantly higher rates of bipolar and @entity23 . CONCLUSIONS: These preliminary observations warrant further studies on genetic, neurological, and psychosocial factors that place some young @entity1 with Down syndrome or other @entity717 at high risk for severe @entity146 .

title: XXXX in adolescents and young adults with Down syndrome and other @entity717 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'people']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric illness']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['intellectual impairment']

entities_list: @entity23 :: ('MESH:D007174', 'Disease') :: ['impulse control disorders']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic', 'psychosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['intellectual disabilities', 'IDs']

answer: @entity146 :: (MESH:D001523,Disease) :: ['Psychiatric disorders']


abstract: BACKGROUND: Relative to other aspects of Down syndrome, remarkably little is known about the @entity146 problems experienced by youth and young adults with this syndrome and if these problems differ from others with @entity717 . Yet adolescence and young adulthood are particularly vulnerable time periods, as they involve multiple life transitions in educational, medical, and other service systems. METHODS: This study compared the @entity146 diagnoses of 49 adolescent and young adult @entity1 with Down syndrome to 70 @entity1 with other @entity717 ( @entity717 ). The groups were similar in age, gender, and level of @entity73 . The 119 @entity1 , aged 13 to 29  years (M   =   21) were evaluated in one of two specialized @entity146 clinics. RESULTS: In contrast to previous literature, those with Down syndrome versus other @entity717 had significantly higher rates of @entity716 NOS or @entity308 with @entity716 features (43% versus 13%). Unlike the ID group, @entity716 was predominantly seen in females with Down syndrome. Marked motoric slowing in performing routine daily activities or in expressive language was manifested in 17% of @entity1 with Down syndrome. No group differences were found in @entity148 or @entity308 , and the ID group had significantly higher rates of bipolar and @entity23 . CONCLUSIONS: These preliminary observations warrant further studies on genetic, neurological, and psychosocial factors that place some young @entity1 with Down syndrome or other @entity717 at high risk for severe @entity146 .

title: @entity146 in adolescents and young adults with Down syndrome and other XXXX .

answer: @entity717 :: (MESH:D009069,Disease) :: ['intellectual disabilities']


abstract: INTRODUCTION: In Africa and Asia hair dye is applied together with henna to decorate the hands and feet. @entity7227 ( @entity10155 ), a highly toxic constituent of hair dye can lead to @entity810 ( @entity810 ). METHODS: A cohort study was conducted during the period from April 2012 to March 2013 in Khartoum Teaching Hospital, Sudan. It targeted adults presenting acutely with an evident history and clinical features of hair dye @entity4968 , together with @entity810 as per the RIFLE criteria. Analysis of data was done using SPSS. RESULTS: 30 adults were included, their mean age was 25.6    4.2 years, 93.3% were females. Exposure to @entity10155 was suicidal in 86.7%. The mean duration to onset of renal symptoms was 34.8    7.6 hours, maximum median serum @entity1011 was 8.6    2.3 mg/dl, 86.7% had @entity8 as per the RIFLE classification and required dialysis. @entity8 was seen after a mean duration of 9.8    2.2 days. One @entity1 died, 3.3%; all others, 96.7%, recovered normal kidney function. The amount of ingested @entity10155 correlated significantly to the severity of symptoms, number of dialysis sessions required and time for renal recovery with P values < 0.05. CONCLUSION: Hair dye @entity4968 was associated with prolonged hospital stay, requirement of dialysis and increased morbidity. The severity of symptoms directly correlates to the dose of @entity10155 ingested, with the @entity8 being reversible in almost all survivors.

title: Clinical presentation, treatment and outcome of XXXX induced @entity810 following hair dye @entity4968 : a cohort study.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Initial renal recovery', 'loss of kidney function', 'kidney damage']

entities_list: @entity7227 :: ('MESH:C029728', 'Chemical') :: ['Paraphenylene-diamine']

entities_list: @entity4968 :: ('MESH:D011041', 'Disease') :: ['poisoning']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity7227 :: (MESH:C029728,Chemical) :: ['paraphenylene-diamine']


abstract: INTRODUCTION: In Africa and Asia hair dye is applied together with henna to decorate the hands and feet. @entity7227 ( @entity10155 ), a highly toxic constituent of hair dye can lead to @entity810 ( @entity810 ). METHODS: A cohort study was conducted during the period from April 2012 to March 2013 in Khartoum Teaching Hospital, Sudan. It targeted adults presenting acutely with an evident history and clinical features of hair dye @entity4968 , together with @entity810 as per the RIFLE criteria. Analysis of data was done using SPSS. RESULTS: 30 adults were included, their mean age was 25.6    4.2 years, 93.3% were females. Exposure to @entity10155 was suicidal in 86.7%. The mean duration to onset of renal symptoms was 34.8    7.6 hours, maximum median serum @entity1011 was 8.6    2.3 mg/dl, 86.7% had @entity8 as per the RIFLE classification and required dialysis. @entity8 was seen after a mean duration of 9.8    2.2 days. One @entity1 died, 3.3%; all others, 96.7%, recovered normal kidney function. The amount of ingested @entity10155 correlated significantly to the severity of symptoms, number of dialysis sessions required and time for renal recovery with P values < 0.05. CONCLUSION: Hair dye @entity4968 was associated with prolonged hospital stay, requirement of dialysis and increased morbidity. The severity of symptoms directly correlates to the dose of @entity10155 ingested, with the @entity8 being reversible in almost all survivors.

title: Clinical presentation, treatment and outcome of @entity7227 induced @entity810 following hair dye XXXX : a cohort study.

answer: @entity4968 :: (MESH:D011041,Disease) :: ['poisoning']


abstract: INTRODUCTION: In Africa and Asia hair dye is applied together with henna to decorate the hands and feet. @entity7227 ( @entity10155 ), a highly toxic constituent of hair dye can lead to @entity810 ( @entity810 ). METHODS: A cohort study was conducted during the period from April 2012 to March 2013 in Khartoum Teaching Hospital, Sudan. It targeted adults presenting acutely with an evident history and clinical features of hair dye @entity4968 , together with @entity810 as per the RIFLE criteria. Analysis of data was done using SPSS. RESULTS: 30 adults were included, their mean age was 25.6    4.2 years, 93.3% were females. Exposure to @entity10155 was suicidal in 86.7%. The mean duration to onset of renal symptoms was 34.8    7.6 hours, maximum median serum @entity1011 was 8.6    2.3 mg/dl, 86.7% had @entity8 as per the RIFLE classification and required dialysis. @entity8 was seen after a mean duration of 9.8    2.2 days. One @entity1 died, 3.3%; all others, 96.7%, recovered normal kidney function. The amount of ingested @entity10155 correlated significantly to the severity of symptoms, number of dialysis sessions required and time for renal recovery with P values < 0.05. CONCLUSION: Hair dye @entity4968 was associated with prolonged hospital stay, requirement of dialysis and increased morbidity. The severity of symptoms directly correlates to the dose of @entity10155 ingested, with the @entity8 being reversible in almost all survivors.

title: Clinical presentation, treatment and outcome of @entity7227 induced XXXX following hair dye @entity4968 : a cohort study.

answer: @entity810 :: (MESH:D058186,Disease) :: ['acute kidney injury']


abstract: BACKGROUND: The incidence of difficult intubation in @entity1 undergoing general anaesthesia is estimated to be approximately 1-18% whereas that of failure to intubate is 0.05-0.35%.1,2,3 Various methods have been used for prediction of difficult laryngoscopy. Although, upper lip bite has been shown to be a promising test in its introductory article, repeated validation in various populations is required for any test to be accepted as a routine test. We have compared upper lip bite test (ULBT), modified Mallampati test (MMC) and @entity5529 ( @entity5529 ) individually and in various combinations to verify which of these predictor tests are significantly associated with difficult glottic exposure. METHODS: After obtaining institutional ethics committee approval, 402 ASA I and II adult @entity1 undergoing elective surgical procedures requiring endotracheal intubation were included. All the three test were performed in all the @entity1 preoperatively and their glottic exposure was recorded by Cormack-Lehane classification during intubation. Sensitivity, specificity, positive predictive value and negative predictive value were used for comparison. RESULTS: In our study, the incidence of difficult laryngoscopy was 11.4% and failure to intubate 0.49%. None of the three are a suitable predictive test when used alone. Combination of tests added incremental diagnostic value. CONCLUSION: We conclude that all three screening tests for difficult intubation have only poor to moderate discriminative power when used alone. Combinations of individual tests add some incremental diagnostic value.

title: Prediction of ease of laryngoscopy and intubation-role of upper lip bite test, modified mallampati classification, and XXXX in various combination.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5529 :: ('MESH:C535290', 'Disease') :: ['thyromental distance', 'TMD']

answer: @entity5529 :: (MESH:C535290,Disease) :: ['thyromental distance']


abstract: UNASSIGNED: Reinforcement occurs when behavioral isolation is strengthened between species due to selection against hybridization in sympatry. Mate preferences and their target traits may change in sympatry as a consequence of reinforcement. This can potentially generate further behavioral isolation within species if sympatric populations evolve extreme preferences or traits that cause them to reject individuals from foreign populations as mates or be rejected as mates. This process is known as cascade reinforcement. We measured behavioral isolation between sympatric and allopatric populations of Lucania @entity22159 to determine whether isolation evolves due to reinforcement between species and whether reinforcement affects preferences within species, consistent with the cascade reinforcement hypothesis. We measured mate preferences in both sexes between species (Lucania parva vs. Lucania goodei) and within species (among populations of @entity46141 ). Between species, both male and female preferences for conspecifics were highest in sympatric populations. Within species, @entity46141 females from sympatric populations preferred their own native males over foreign males. Allopatric @entity46141 females and all @entity46141 males showed no preferences within species. Within species, behavioral isolation showed no association with ecological variables, such as salinity. Thus, reinforcement is a primary factor generating behavioral isolation in Lucania @entity22159 , creating strong preferences in both sexes among species and leading to cascade reinforcement of female mate preference within species.

title: Behavioral Isolation due to Cascade Reinforcement in Lucania XXXX .

answer: @entity22159 :: (8078,Species) :: ['Killifish']


abstract: Importance: @entity421 of the jaws is rare and clinically distinct from @entity421 of the long bones of the body with different treatment and outcomes. The literature on these @entity5 is limited to case reports and small case series mostly from single institutions. We used data from the population-based national Surveillance, Epidemiology and End Results (SEER) @entity5 registry to determine the epidemiology and prognostic factors associated with @entity421 of the jaws. Objective: To investigate the epidemiologic characteristics and prognostic factors for survival in @entity1 diagnosed with @entity421 of the jaws. Design, Setting, and @entity1 : A retrospective, population-based cohort study of 541 @entity1 in the SEER @entity5 registry diagnosed with @entity421 of the jaws from 1973 through 2011 were reviewed. Exposures: @entity1 had been treated with surgery, radiation, both, or neither. Main Outcomes and Measures: Overall and @entity66 . Results: A total of 541 @entity1 diagnosed with @entity421 of the jaws were identified (49.9% male and 50.1% female, with a mean age of 41.3 years). Kaplan-Meier analysis demonstrated an @entity1349 ( @entity1349 ) and @entity66 ( @entity66 ) of 53% and 62%, respectively, at 5 years and 35% and 54%, respectively, at 10 years. Multivariate Cox regression analysis revealed that independent predictors of @entity1349 and @entity66 included age at diagnosis (hazard ratio [HR], 1.03; 95% CI, 1.02-1.04 [P   <   .001] for @entity1349 ; and HR, 1.03; 95% CI, 1.02-1.05 [P   <   .001] for @entity66 ); stage at presentation (HR, 1.37; 95% CI, 1.10-1.71 [P   =   .006] for @entity1349 ; and HR, 1.34; 95% CI, 1.01-1.76 [P   =   .04] for @entity66 ); and surgical resection (HR, 0.31; 95% CI, 0.16-0.60 [P   <   .001] for @entity1349 ; and HR, 0.22; 95% CI, 0.09-0.56 [P   =   .001] for @entity66 ). @entity5 size was not significant for @entity1349 (HR, 1.00; 95% CI, 1.00-1.01 [P   =   .11] but significant for @entity66 (HR, 1.01; 95% CI, 1.00-1.01 [P   =   .003]). Conclusions and Relevance: To our knowledge, this is the largest study to date investigating prognostic factors for survival in @entity1 diagnosed with @entity421 of the jaws. Determinants of survival include age at diagnosis, stage at presentation, @entity5 size, and surgical therapy. Radiation therapy was not associated with improved survival, reflecting the controversy surrounding its use in in clinical literature.

title: Characteristics and Prognostic Factors of XXXX of the Jaws: A Retrospective Cohort Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Participants']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['DSS', 'disease-specific survival']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Tumor', 'tumors']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['Osteosarcoma', 'osteosarcoma']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity421 :: (MESH:D012516,Disease) :: ['Osteosarcoma']


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity272 . Although, the molecular mechanism is not completely understood, @entity1569 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity9554 (eNOS @entity15379 ) gene polymorphism in @entity101 and/or non- @entity101 @entity5144 @entity1 (2) to investigate the possible relationship between the eNOS @entity15379 polymorphism and the risk of @entity101 among @entity5144 @entity1 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity233 @entity1 and Methods: Gene profiles of 75 @entity5144 @entity1 (21 @entity101 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5144 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity1 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity15379 single-nucleotide polymorphism (SNP) was determined in @entity5144 @entity1 when compared with normotensive non- @entity5144 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity101 @entity5144 @entity1 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5144 @entity1 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity15379 polymorphism and @entity101 among @entity5144 @entity1 in the Turkish population. The T allele frequency of eNOS @entity15379 SNP was different in @entity101 @entity5144 @entity1 , and the difference was statistically significant when compared with the normotensive @entity5144 @entity1 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of @entity9554 XXXX gene polymorphism in @entity1569 cases with @entity101 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity9554 :: ('4846', 'Gene') :: ['endothelial nitric oxide synthase']

entities_list: @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease']

entities_list: @entity15379 :: ('p|SUB|E|298|D', 'ProteinMutation') :: ['Glu298Asp']

answer: @entity15379 :: (p|SUB|E|298|D,ProteinMutation) :: ['Glu298Asp']


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity272 . Although, the molecular mechanism is not completely understood, @entity1569 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity9554 (eNOS @entity15379 ) gene polymorphism in @entity101 and/or non- @entity101 @entity5144 @entity1 (2) to investigate the possible relationship between the eNOS @entity15379 polymorphism and the risk of @entity101 among @entity5144 @entity1 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity233 @entity1 and Methods: Gene profiles of 75 @entity5144 @entity1 (21 @entity101 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5144 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity1 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity15379 single-nucleotide polymorphism (SNP) was determined in @entity5144 @entity1 when compared with normotensive non- @entity5144 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity101 @entity5144 @entity1 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5144 @entity1 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity15379 polymorphism and @entity101 among @entity5144 @entity1 in the Turkish population. The T allele frequency of eNOS @entity15379 SNP was different in @entity101 @entity5144 @entity1 , and the difference was statistically significant when compared with the normotensive @entity5144 @entity1 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of @entity9554 @entity15379 gene polymorphism in XXXX cases with @entity101 .

answer: @entity1569 :: (MESH:D011565,Disease) :: ['psoriasis']


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity272 . Although, the molecular mechanism is not completely understood, @entity1569 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity9554 (eNOS @entity15379 ) gene polymorphism in @entity101 and/or non- @entity101 @entity5144 @entity1 (2) to investigate the possible relationship between the eNOS @entity15379 polymorphism and the risk of @entity101 among @entity5144 @entity1 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity233 @entity1 and Methods: Gene profiles of 75 @entity5144 @entity1 (21 @entity101 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5144 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity1 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity15379 single-nucleotide polymorphism (SNP) was determined in @entity5144 @entity1 when compared with normotensive non- @entity5144 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity101 @entity5144 @entity1 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5144 @entity1 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity15379 polymorphism and @entity101 among @entity5144 @entity1 in the Turkish population. The T allele frequency of eNOS @entity15379 SNP was different in @entity101 @entity5144 @entity1 , and the difference was statistically significant when compared with the normotensive @entity5144 @entity1 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of @entity9554 @entity15379 gene polymorphism in @entity1569 cases with XXXX .

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: BACKGROUND AND OBJECTIVES: Psoriasis is a common autoimmune-mediated chronic, inflammatory @entity272 . Although, the molecular mechanism is not completely understood, @entity1569 is caused by genetic and non-genetic parameters. The current study aimed (1) to define genotype and allele frequency of @entity9554 (eNOS @entity15379 ) gene polymorphism in @entity101 and/or non- @entity101 @entity5144 @entity1 (2) to investigate the possible relationship between the eNOS @entity15379 polymorphism and the risk of @entity101 among @entity5144 @entity1 in the Turkish population. DESIGN AND SETTINGS: This cross-sectional, case-control study was performed between March 2010 and November 2012 at the University hospital in   anakkale, @entity233 @entity1 and Methods: Gene profiles of 75 @entity5144 @entity1 (21 @entity101 and 54 normotensive pa.tients) and 55 healthy (normotensive and non- @entity5144 ) volunteers were compared. Peripheral blood-EDTA samples were used for total genomic DNA isolation and genotyping. Target eNOS gene was genotyped for @entity1 and control groups by real-time PCR melting-curve analysis system (LightCycler 2.0,Roche, Germany, and results were compared statistically. RESULTS: An increased T allele frequency in eNOS @entity15379 single-nucleotide polymorphism (SNP) was determined in @entity5144 @entity1 when compared with normotensive non- @entity5144 healthy volunteers (OR 2.3, CI 1.14-3.99), (P=.017). The T allele frequency was also found to be increased in @entity101 @entity5144 @entity1 when compared with healthy volunteers (4.83-fold increased, 95% CI 1.62-14.43 ([P=.003]) and normotensive @entity5144 @entity1 (3.03-fold increased, 95% CI 1.03-8.94 [P=.041]), respectively. CONCLUSION: The current preliminary results suggested that there was a correlation between eNOS @entity15379 polymorphism and @entity101 among @entity5144 @entity1 in the Turkish population. The T allele frequency of eNOS @entity15379 SNP was different in @entity101 @entity5144 @entity1 , and the difference was statistically significant when compared with the normotensive @entity5144 @entity1 and healthy controls. These results need to be confirmed by large-scale studies.

title: Association of XXXX @entity15379 gene polymorphism in @entity1569 cases with @entity101 .

answer: @entity9554 :: (4846,Gene) :: ['endothelial nitric oxide synthase']


abstract: UNASSIGNED: Vascular characteristics, hypoxia and tumor budding are features that have been implied in the biology and prognosis of @entity14 . Internal relationships and the inter- and intra-tumoral variation of these tumor properties remain to be determined. In the current study we have characterized blood vessel status in different areas of @entity14 and in the peritumoral fibroblastic stroma. Analyses of these characteristics have been supplemented by characterization of budding and hypoxia. Analyses revealed significantly lower values of @entity6520 ( @entity6520 ) and @entity6520 ( @entity6520 ) at the invasive front and surrounding stroma as compared to the tumor center. Also, the number of vessels (VN) in the peritumoral stroma was higher than in the center. Thus, tumor center displays larger and fewer vessels as compared to the tumor periphery. @entity1365 expression was correlated directly with VN (r=0.351, p=0.028) and inversely with @entity6520 and @entity6520 (r=-0.432, p=0.006 and r=-0.484, p=0.002) at the invasive front. Moreover, @entity1365 expression, @entity6520 at the invasive front, and VN in the surrounding peritumoral stroma, were associated with budding score (r=0.574, p<0.000, r=-0.340, p=0,034 and r=-0.389, p=0.025 respectively). Furthermore, @entity1365 , budding score, vessel number in peritumoral stroma, and vessel size in the invasive front, were significantly different in tumors with or without lymph node metastasis. This study reports previously unrecognized relationships between localization-specific vascular characteristics, hypoxia and tumor budding. The findings suggest potential functional relationships, which should be further explored, and also highlight the inter-tumoral variations in vasculature, which is highly relevant for ongoing efforts to identify vessel-based biomarkers.

title: Inter- and intra-tumoral relationships between vasculature characteristics, XXXX and budding in @entity14 .

entities_list: @entity6520 :: ('MESH:C536223', 'Disease') :: ['VL', 'vessel perimeter', 'VP', 'vessel lumen area']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

answer: @entity1365 :: (6513,Gene) :: ['GLUT1']


abstract: UNASSIGNED: Vascular characteristics, hypoxia and tumor budding are features that have been implied in the biology and prognosis of @entity14 . Internal relationships and the inter- and intra-tumoral variation of these tumor properties remain to be determined. In the current study we have characterized blood vessel status in different areas of @entity14 and in the peritumoral fibroblastic stroma. Analyses of these characteristics have been supplemented by characterization of budding and hypoxia. Analyses revealed significantly lower values of @entity6520 ( @entity6520 ) and @entity6520 ( @entity6520 ) at the invasive front and surrounding stroma as compared to the tumor center. Also, the number of vessels (VN) in the peritumoral stroma was higher than in the center. Thus, tumor center displays larger and fewer vessels as compared to the tumor periphery. @entity1365 expression was correlated directly with VN (r=0.351, p=0.028) and inversely with @entity6520 and @entity6520 (r=-0.432, p=0.006 and r=-0.484, p=0.002) at the invasive front. Moreover, @entity1365 expression, @entity6520 at the invasive front, and VN in the surrounding peritumoral stroma, were associated with budding score (r=0.574, p<0.000, r=-0.340, p=0,034 and r=-0.389, p=0.025 respectively). Furthermore, @entity1365 , budding score, vessel number in peritumoral stroma, and vessel size in the invasive front, were significantly different in tumors with or without lymph node metastasis. This study reports previously unrecognized relationships between localization-specific vascular characteristics, hypoxia and tumor budding. The findings suggest potential functional relationships, which should be further explored, and also highlight the inter-tumoral variations in vasculature, which is highly relevant for ongoing efforts to identify vessel-based biomarkers.

title: Inter- and intra-tumoral relationships between vasculature characteristics, @entity1365 and budding in XXXX .

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinoma']


abstract: BACKGROUND: @entity1072 and @entity1072 are 2 different presentations of the most common @entity1892 in western countries ( @entity1072 ). In this disease, @entity8 is usually silent, and is rarely reported in the literature. This study provides a clinicopathological analysis of all-cause @entity8 in @entity1072 @entity1 . METHODS: Fifteen @entity1072 @entity1 with kidney biopsy were identified retrospectively. Demographic, clinical, pathological and laboratory data were assessed at biopsy, and during follow-up. RESULTS: At biopsy 11 @entity1 presented @entity8 , 7 @entity1 @entity1985 , 6 @entity1 dysproteinemia, and 3 @entity1 @entity14033 . Kidney pathology revealed @entity1072 -specific monoclonal infiltrate in 10 biopsies, @entity8 in 9 biopsies (5 membranoproliferative @entity631 , 2 minimal change disease, 1 @entity631 with organized microtubular monoclonal immunoglobulin deposits, 1 @entity2783 ). Five @entity1 presented @entity1986 attributed to @entity1072 . After treatment of the @entity1503 , improvement of renal function was observed in 7/11 @entity1 , and remission of @entity1985 in 5/7 @entity1 . During follow-up, aggravation of the @entity8 systematically occurred in the absence of favorable response to hematological treatment. CONCLUSIONS: A broad spectrum of @entity8 is associated with @entity1072 . In this setting, kidney biopsy can provide important information for diagnosis and therapeutic guidance.

title: The Spectrum of Kidney Pathology in @entity1072 / XXXX : A 25-Year Multicenter Experience.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['kidney diseases', 'kidney involvement', 'glomerulopathy', 'kidney disease', 'impaired renal function']

entities_list: @entity2783 :: ('MESH:D000686', 'Disease') :: ['AHL amyloidosis']

entities_list: @entity14033 :: ('MESH:D003449', 'Disease') :: ['cryoglobulinemia']

entities_list: @entity1072 :: ('MESH:D015451', 'Disease') :: ['CLL/SLL', 'small lymphocytic lymphoma', 'Chronic lymphocytic leukemia']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematological disease']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell neoplasm']

entities_list: @entity1986 :: ('MESH:D009395', 'Disease') :: ['interstitial granulomas']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

answer: @entity1072 :: (MESH:D015451,Disease) :: ['Small Lymphocytic Lymphoma']


abstract: BACKGROUND: @entity1072 and @entity1072 are 2 different presentations of the most common @entity1892 in western countries ( @entity1072 ). In this disease, @entity8 is usually silent, and is rarely reported in the literature. This study provides a clinicopathological analysis of all-cause @entity8 in @entity1072 @entity1 . METHODS: Fifteen @entity1072 @entity1 with kidney biopsy were identified retrospectively. Demographic, clinical, pathological and laboratory data were assessed at biopsy, and during follow-up. RESULTS: At biopsy 11 @entity1 presented @entity8 , 7 @entity1 @entity1985 , 6 @entity1 dysproteinemia, and 3 @entity1 @entity14033 . Kidney pathology revealed @entity1072 -specific monoclonal infiltrate in 10 biopsies, @entity8 in 9 biopsies (5 membranoproliferative @entity631 , 2 minimal change disease, 1 @entity631 with organized microtubular monoclonal immunoglobulin deposits, 1 @entity2783 ). Five @entity1 presented @entity1986 attributed to @entity1072 . After treatment of the @entity1503 , improvement of renal function was observed in 7/11 @entity1 , and remission of @entity1985 in 5/7 @entity1 . During follow-up, aggravation of the @entity8 systematically occurred in the absence of favorable response to hematological treatment. CONCLUSIONS: A broad spectrum of @entity8 is associated with @entity1072 . In this setting, kidney biopsy can provide important information for diagnosis and therapeutic guidance.

title: The Spectrum of Kidney Pathology in XXXX / @entity1072 : A 25-Year Multicenter Experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity1072 :: (MESH:D015451,Disease) :: ['B-Cell Chronic Lymphocytic Leukemia']


abstract: UNASSIGNED: Background: Over the course of @entity5 towards the end-of-life, @entity1 may experience symptoms that lead to distressing @entity3124 ( @entity3124 ) for the @entity1 and caregivers. Methods: We analysed the records of 133 @entity1 cared for by our paediatric palliative care team (PPCT) from 01/98-12/09. A @entity3124 was defined as deterioration of a condition caused by a symptom, which was life-threatening or acutely scaring the @entity1 (pt) or caregivers. Results: The majority of pts who died sustained no @entity3124 . In 38 (28.6%) pts 45 @entity3124 occurred. These accumulated towards the end-of-life (62.2% within the last week). About two-thirds were anticipated. There was no clustering of @entity3124 during the night/weekend. Leading symptoms were neurological. In 4 @entity3124 a pre-hospital emergency physician was alerted. 5 pts were readmitted to hospital. Most @entity3124 (88.9%) could be controlled in the home setting. Discussion: Despite anticipation, a relevant number of pts developed @entity3124 , which needed either additional medical intervention or other support by the PPCT. Considering the distressing and suffering character of @entity159 and dyspnoea, it is important to thoroughly address these conditions in palliative care. Conclusion: Advanced planning, close contact, good communication, detailed parental information, and a 24-h on-call service can reduce @entity3124 in @entity1 with @entity5 . @entity3124 are mainly manageable within the home setting. Treatment of @entity3124 should focus on the @entity1 's symptoms and wishes, and the needs of the whole family.

title: Critical Situations in @entity1 , Adolescents and Young Adults with XXXX within the Home Setting.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['terminal cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patient', 'child']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['CS', 'critical situations']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Terminal Cancer']


abstract: UNASSIGNED: Background: Over the course of @entity5 towards the end-of-life, @entity1 may experience symptoms that lead to distressing @entity3124 ( @entity3124 ) for the @entity1 and caregivers. Methods: We analysed the records of 133 @entity1 cared for by our paediatric palliative care team (PPCT) from 01/98-12/09. A @entity3124 was defined as deterioration of a condition caused by a symptom, which was life-threatening or acutely scaring the @entity1 (pt) or caregivers. Results: The majority of pts who died sustained no @entity3124 . In 38 (28.6%) pts 45 @entity3124 occurred. These accumulated towards the end-of-life (62.2% within the last week). About two-thirds were anticipated. There was no clustering of @entity3124 during the night/weekend. Leading symptoms were neurological. In 4 @entity3124 a pre-hospital emergency physician was alerted. 5 pts were readmitted to hospital. Most @entity3124 (88.9%) could be controlled in the home setting. Discussion: Despite anticipation, a relevant number of pts developed @entity3124 , which needed either additional medical intervention or other support by the PPCT. Considering the distressing and suffering character of @entity159 and dyspnoea, it is important to thoroughly address these conditions in palliative care. Conclusion: Advanced planning, close contact, good communication, detailed parental information, and a 24-h on-call service can reduce @entity3124 in @entity1 with @entity5 . @entity3124 are mainly manageable within the home setting. Treatment of @entity3124 should focus on the @entity1 's symptoms and wishes, and the needs of the whole family.

title: Critical Situations in XXXX , Adolescents and Young Adults with @entity5 within the Home Setting.

answer: @entity1 :: (9606,Species) :: ['Children']