abstract: To review the management of @entity1321 associated with @entity13374 , the authors studied the records of 368 @entity1 with @entity1321 . Most @entity1 (83%) had gynecologic @entity5 . Obstruction of the small intestines was more common than obstruction of the large intestines (77% versus 23%). Major causes of mechanical small @entity1744 included extrinsic @entity5 (62%, mostly @entity43 ), radiation therapy-associated strictures and adhesions (17%), @entity86 (14%), and inflammatory strictures and adhesions (3%). Obstruction of the colon was caused mainly by extrinsic @entity5 (45%), strictures and adhesions associated with radiation therapy (26%), fecal impaction (9%), and intrinsic @entity5 (8%). Gastrointestinal intubation successfully relieved 81% of small @entity1744 caused by @entity86 . Tube suction alone was rarely successful when the obstruction was caused by @entity5 . The prognosis was dependent on the cause of the underlying disease. The cases studied in this report were compared with a large number of cases of @entity1744 in general surgery. It is concluded that @entity1744 associated with @entity13374 has unique features deserving wider recognition.

title: Mechanical XXXX in @entity1 with @entity13374 : a review of 368 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian carcinomas']

entities_list: @entity13374 :: ('MESH:D005831', 'Disease') :: ['gynecologic disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant neoplasms', 'neoplasms', 'malignancies']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction', 'acute intestinal obstruction']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative adhesions']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['bowel obstruction', 'bowel obstructions']

answer: @entity1321 :: (MESH:D007415,Disease) :: ['intestinal obstruction']


abstract: To review the management of @entity1321 associated with @entity13374 , the authors studied the records of 368 @entity1 with @entity1321 . Most @entity1 (83%) had gynecologic @entity5 . Obstruction of the small intestines was more common than obstruction of the large intestines (77% versus 23%). Major causes of mechanical small @entity1744 included extrinsic @entity5 (62%, mostly @entity43 ), radiation therapy-associated strictures and adhesions (17%), @entity86 (14%), and inflammatory strictures and adhesions (3%). Obstruction of the colon was caused mainly by extrinsic @entity5 (45%), strictures and adhesions associated with radiation therapy (26%), fecal impaction (9%), and intrinsic @entity5 (8%). Gastrointestinal intubation successfully relieved 81% of small @entity1744 caused by @entity86 . Tube suction alone was rarely successful when the obstruction was caused by @entity5 . The prognosis was dependent on the cause of the underlying disease. The cases studied in this report were compared with a large number of cases of @entity1744 in general surgery. It is concluded that @entity1744 associated with @entity13374 has unique features deserving wider recognition.

title: Mechanical @entity1321 in @entity1 with XXXX : a review of 368 @entity1 .

answer: @entity13374 :: (MESH:D005831,Disease) :: ['gynecologic disease']


abstract: To review the management of @entity1321 associated with @entity13374 , the authors studied the records of 368 @entity1 with @entity1321 . Most @entity1 (83%) had gynecologic @entity5 . Obstruction of the small intestines was more common than obstruction of the large intestines (77% versus 23%). Major causes of mechanical small @entity1744 included extrinsic @entity5 (62%, mostly @entity43 ), radiation therapy-associated strictures and adhesions (17%), @entity86 (14%), and inflammatory strictures and adhesions (3%). Obstruction of the colon was caused mainly by extrinsic @entity5 (45%), strictures and adhesions associated with radiation therapy (26%), fecal impaction (9%), and intrinsic @entity5 (8%). Gastrointestinal intubation successfully relieved 81% of small @entity1744 caused by @entity86 . Tube suction alone was rarely successful when the obstruction was caused by @entity5 . The prognosis was dependent on the cause of the underlying disease. The cases studied in this report were compared with a large number of cases of @entity1744 in general surgery. It is concluded that @entity1744 associated with @entity13374 has unique features deserving wider recognition.

title: Mechanical @entity1321 in XXXX with @entity13374 : a review of 368 @entity1 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: To review the management of @entity1321 associated with @entity13374 , the authors studied the records of 368 @entity1 with @entity1321 . Most @entity1 (83%) had gynecologic @entity5 . Obstruction of the small intestines was more common than obstruction of the large intestines (77% versus 23%). Major causes of mechanical small @entity1744 included extrinsic @entity5 (62%, mostly @entity43 ), radiation therapy-associated strictures and adhesions (17%), @entity86 (14%), and inflammatory strictures and adhesions (3%). Obstruction of the colon was caused mainly by extrinsic @entity5 (45%), strictures and adhesions associated with radiation therapy (26%), fecal impaction (9%), and intrinsic @entity5 (8%). Gastrointestinal intubation successfully relieved 81% of small @entity1744 caused by @entity86 . Tube suction alone was rarely successful when the obstruction was caused by @entity5 . The prognosis was dependent on the cause of the underlying disease. The cases studied in this report were compared with a large number of cases of @entity1744 in general surgery. It is concluded that @entity1744 associated with @entity13374 has unique features deserving wider recognition.

title: Mechanical @entity1321 in @entity1 with @entity13374 : a review of 368 XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Episodes of transient @entity741 during daily life were investigated in 30 @entity1 on two separate occasions, by ambulatory Holter ST monitoring. The first occasion was at a time of uncertainty in the @entity1 ' lives, when the results of coronary angiography and the need for surgery were to be discussed. The second was at a later date, when there had been time to adjust to the decision-making process. There were 515 episodes of @entity741 of which 174 were associated with @entity158 and 341 were asymptomatic. Silent @entity63 was significantly more frequent during the first period of monitoring compared to the second (p less than 0.02). @entity1 who had more @entity63 on the first occasion also entered more self reports of "emotional upset" ( @entity2701 , worry, etc.,) in their diaries compared to the second occasion. The level of urinary @entity701 was taken as a measure of uncertainty and worry, and was significantly higher on the first occasion (p less than 0.03). Differences in urinary @entity1063 excretion were taken as a measure of subjective stress. @entity1 who excreted more @entity1063 on the first compared to the second occasion had significantly more @entity63 (p less than 0.007) and longer total ischemic time (p less than 0.01). We suggest that psychological stress may exacerbate @entity741 which is frequently painless.

title: Psychological stress and silent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['silent ischemia', 'ischemia']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['myocardial ischemia']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']

answer: @entity741 :: (MESH:D017202,Disease) :: ['myocardial ischemia']


abstract: OBJECTIVES: Gastric pull-up is a common technique in the reconstruction of gastrointestinal continuity following surgery for the primary esophageal and @entity5 with involvement of the esophagus. We evaluated the results of surgery in @entity1 with cervical esophageal and @entity5 . @entity1 AND METHODS: Eleven @entity1 (4 @entity1 , 7 @entity1 ; mean age 46 years; range 18 to 70 years) underwent surgery for hypopharyngeal and cervical @entity418 . Surgery included pharyngolaryngoesophagectomy, subtotal thyroidectomy, and gastric pull-up in all @entity1 . In addition, nine @entity1 had radical neck dissection on the involved side and modified radical neck dissection on the contralateral side. One @entity1 had bilateral radical neck dissection. @entity1 who were alive were followed-up for a mean period of 27 months (range 14 to 46 months). RESULTS: The one-, two-, and three-year survival rates were 54% (6/11), 36% (4/11) and 18% (2/11), respectively. Three @entity1 died from early postoperative complications, two from organ failure due to locoregional recurrence (7th month) and to distant @entity3 (11th month). CONCLUSION: Despite the small size of the study, the results favor the use of gastric pull-up in selected @entity1 with cervical esophageal and @entity5 .

title: [Gastric pull-up in hypopharyngeal and cervical XXXX ].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['hypopharyngeal cancers', 'hypopharyngeal tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal epidermoid carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity418 :: (MESH:D004938,Disease) :: ['esophageal cancers']


abstract: 23 @entity1 were treated during 1977-87 in a special hospital in Warsaw for @entity249 by administering the Mell-Krat scale, the Rorschach test, and a test consisting of drawing figures. Most of them were in the 26-35 age group and had secondary and higher level education. 15 of them had a domineering mother, and 13 were only @entity1 . 14 had been married for 5 years and had used a biological method of contraception for 5-8 years. The personality tests indicated that 16 were @entity44 and 5 were neurotic; in 13, the marital roles were reversed; the need for fatherhood was lacking in 7, and it was deficient in 9; 17 had disorders of erection, 4 had @entity2754 , and 2 half diminished libido; the partners of 9 were tolerant and passive concerning the @entity250 , 7 were critical and castrating, and 4 were understanding and helpful. The causative factors and the effectiveness of treatment were: partner-related in 13 cases (9 treated), stereotypical transformation of cohabitation in 23 cases (14 treated), burdensome sexual activity in 3 cases (1 treated), and 4 unknown factors (1 treated). Various therapeutic methods were used: hypnosis, psychotherapy of married couple, and training. 14 @entity1 were successfully treated and rehabilitated; however, 9 @entity1 did not improve. Although the small number of this sample does not permit the drawing of sweeping conclusions, some inferences could be made on forms of @entity323 of psychogenic origin. Implicated factors were: having a domineering mother, being an only @entity1 , and @entity44 personality. Other causes had to do with the partner, sexual duty, and stereotypical sexual cohabitation of many years' duration during a nonfertile period of the @entity1 using a natural method of contraception.

title: [Cyclic XXXX in male infertility].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'woman', 'child', 'men']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['impotence']

entities_list: @entity2754 :: ('MESH:D061686', 'Disease') :: ['premature ejaculation']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['immature']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity323 :: (MESH:D007172,Disease) :: ['impotence']


abstract: OBJECTIVE: To compare the characteristics of @entity227 in primary @entity2747 (PACG) and @entity725 ( @entity725 ). METHODS: Subjects with @entity726 aged 30 years and older were prospectively considered for inclusion. Automated static white-on-white perimetry was performed. A minimum of 2 reliable tests was required with a @entity5494 ( @entity5494 ) within 2 dB on 2 tests. Subjects with previous symptomatic angle-closure, normal-tension @entity726 , visually significant @entity231 , or previous intraocular surgery were excluded. RESULTS: Of 234 subjects assessed, 129 had @entity725 , and 105 had PACG. The MDs ( @entity725 group, -13.3 dB; PACG group, -18.0 dB) indicated more severe @entity227 in subjects with PACG. In subjects with @entity725 , the superior hemifield was more severely affected than the inferior. This was less pronounced in subjects with PACG. Following stratification by @entity5494 , the difference between hemifields was marked in the mild (-10 dB<or= @entity5494 ) and moderate (-20 dB<or= @entity5494 <-10 dB) subgroups but was not present in the severe ( @entity5494 <-20 dB) subgroup. We detected differences between @entity725 and PACG in retinal sensitivity between the superior and inferior hemifields, independent of severity of damage. CONCLUSIONS: The pattern of @entity227 was different in the 2 diseases. This may give insight into the pattern of @entity227 in predominantly pressure-dependent @entity1781 .

title: The severity and spatial distribution of XXXX in @entity726 : a comparison of @entity725 and primary @entity2747 .

entities_list: @entity725 :: ('MESH:C562750', 'Disease') :: ['primary open-angle glaucoma', 'POAG']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'visual field defects', 'visual field loss']

entities_list: @entity5494 :: ('MESH:D010262', 'Disease') :: ['MD', 'mean deviation']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma', 'primary glaucoma']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['glaucomatous optic neuropathy']

entities_list: @entity2747 :: ('MESH:D015812', 'Disease') :: ['angle-closure glaucoma']

answer: @entity227 :: (MESH:D014786,Disease) :: ['visual field defects']


abstract: OBJECTIVE: To compare the characteristics of @entity227 in primary @entity2747 (PACG) and @entity725 ( @entity725 ). METHODS: Subjects with @entity726 aged 30 years and older were prospectively considered for inclusion. Automated static white-on-white perimetry was performed. A minimum of 2 reliable tests was required with a @entity5494 ( @entity5494 ) within 2 dB on 2 tests. Subjects with previous symptomatic angle-closure, normal-tension @entity726 , visually significant @entity231 , or previous intraocular surgery were excluded. RESULTS: Of 234 subjects assessed, 129 had @entity725 , and 105 had PACG. The MDs ( @entity725 group, -13.3 dB; PACG group, -18.0 dB) indicated more severe @entity227 in subjects with PACG. In subjects with @entity725 , the superior hemifield was more severely affected than the inferior. This was less pronounced in subjects with PACG. Following stratification by @entity5494 , the difference between hemifields was marked in the mild (-10 dB<or= @entity5494 ) and moderate (-20 dB<or= @entity5494 <-10 dB) subgroups but was not present in the severe ( @entity5494 <-20 dB) subgroup. We detected differences between @entity725 and PACG in retinal sensitivity between the superior and inferior hemifields, independent of severity of damage. CONCLUSIONS: The pattern of @entity227 was different in the 2 diseases. This may give insight into the pattern of @entity227 in predominantly pressure-dependent @entity1781 .

title: The severity and spatial distribution of @entity227 in XXXX : a comparison of @entity725 and primary @entity2747 .

answer: @entity726 :: (MESH:D005901,Disease) :: ['primary glaucoma']


abstract: OBJECTIVE: To compare the characteristics of @entity227 in primary @entity2747 (PACG) and @entity725 ( @entity725 ). METHODS: Subjects with @entity726 aged 30 years and older were prospectively considered for inclusion. Automated static white-on-white perimetry was performed. A minimum of 2 reliable tests was required with a @entity5494 ( @entity5494 ) within 2 dB on 2 tests. Subjects with previous symptomatic angle-closure, normal-tension @entity726 , visually significant @entity231 , or previous intraocular surgery were excluded. RESULTS: Of 234 subjects assessed, 129 had @entity725 , and 105 had PACG. The MDs ( @entity725 group, -13.3 dB; PACG group, -18.0 dB) indicated more severe @entity227 in subjects with PACG. In subjects with @entity725 , the superior hemifield was more severely affected than the inferior. This was less pronounced in subjects with PACG. Following stratification by @entity5494 , the difference between hemifields was marked in the mild (-10 dB<or= @entity5494 ) and moderate (-20 dB<or= @entity5494 <-10 dB) subgroups but was not present in the severe ( @entity5494 <-20 dB) subgroup. We detected differences between @entity725 and PACG in retinal sensitivity between the superior and inferior hemifields, independent of severity of damage. CONCLUSIONS: The pattern of @entity227 was different in the 2 diseases. This may give insight into the pattern of @entity227 in predominantly pressure-dependent @entity1781 .

title: The severity and spatial distribution of @entity227 in @entity726 : a comparison of @entity725 and primary XXXX .

answer: @entity2747 :: (MESH:D015812,Disease) :: ['angle-closure glaucoma']


abstract: OBJECTIVE: To compare the characteristics of @entity227 in primary @entity2747 (PACG) and @entity725 ( @entity725 ). METHODS: Subjects with @entity726 aged 30 years and older were prospectively considered for inclusion. Automated static white-on-white perimetry was performed. A minimum of 2 reliable tests was required with a @entity5494 ( @entity5494 ) within 2 dB on 2 tests. Subjects with previous symptomatic angle-closure, normal-tension @entity726 , visually significant @entity231 , or previous intraocular surgery were excluded. RESULTS: Of 234 subjects assessed, 129 had @entity725 , and 105 had PACG. The MDs ( @entity725 group, -13.3 dB; PACG group, -18.0 dB) indicated more severe @entity227 in subjects with PACG. In subjects with @entity725 , the superior hemifield was more severely affected than the inferior. This was less pronounced in subjects with PACG. Following stratification by @entity5494 , the difference between hemifields was marked in the mild (-10 dB<or= @entity5494 ) and moderate (-20 dB<or= @entity5494 <-10 dB) subgroups but was not present in the severe ( @entity5494 <-20 dB) subgroup. We detected differences between @entity725 and PACG in retinal sensitivity between the superior and inferior hemifields, independent of severity of damage. CONCLUSIONS: The pattern of @entity227 was different in the 2 diseases. This may give insight into the pattern of @entity227 in predominantly pressure-dependent @entity1781 .

title: The severity and spatial distribution of @entity227 in @entity726 : a comparison of XXXX and primary @entity2747 .

answer: @entity725 :: (MESH:C562750,Disease) :: ['primary open-angle glaucoma']


abstract: OBJECTIVE: To investigate whether nutritional factors and possible risk factors for @entity231 influence the lens optical density (LOD). DESIGN: Three hundred seventy-six subjects, aged 18 to 75 years, were recruited. In a cross-sectional design, serum was analyzed for @entity8665 , @entity7695 , @entity620 , @entity1881 , and @entity165 levels. Adipose tissue (n = 187) was analyzed for @entity8665 level. The LOD and the @entity2118 ( @entity2118 ) were measured by spectral fundus reflectance. RESULTS: The mean +/- SD LOD at 420 nm was 0.52 +/- 0.17. It showed a significant association with age (beta =.008, P<001) and @entity2118 (beta = -.096, P =.02). For subjects 50 years and younger (mean +/- SD LOD, 0.45 +/- 0.11), we found only a single significant beta coefficient, for age (beta =.006, P<.001). For subjects older than 50 years (mean +/- SD LOD, 0.68 +/- 0.16), we found significant beta coefficients for age (beta =.011, P<.001) and @entity2118 (beta = -.240, P =.005). Controlling for age, we found no associations between LOD and other possible risk factors for age-related @entity231 or serum or adipose tissue concentrations of carotenoids, @entity620 , and @entity1881 . CONCLUSIONS: Macular pigment is composed of @entity8665 and @entity7695 , the only carotenoids found in @entity1 lenses. The inverse relationship between LOD and @entity2118 suggests that @entity8665 and @entity7695 may retard aging of the lens.

title: Lens aging in relation to nutritional determinants and possible risk factors for age-related XXXX .

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['vitamin C']

entities_list: @entity7695 :: ('MESH:C005881', 'Chemical') :: ['zeaxanthin']

entities_list: @entity1881 :: ('MESH:D024502', 'Chemical') :: ['alpha-tocopherol']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity2118 :: ('MESH:D010859', 'Disease') :: ['MPOD', 'macular pigment optical density']

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']


abstract: Family therapy has emerged as the treatment of choice for young @entity1 with @entity1278 , yet there is insufficient knowledge about what actually happens within the family unit in these cases. The purpose of the present study was to investigate how a family undergoing treatment due to an anorectic @entity1 changes their mode of functioning. Twenty-six families were studied. The concepts chosen in the study were closely linked to fundamental principles advocated by the therapeutic model used in the treatment, using a multi-method approach with both observer ratings and self-rating questionnaires. According to observer ratings, the families had changed towards a more functional pattern on all dimensions rated. They had a clearer hierarchy and a higher degree of competency. Cohesion and Adaptability had changed towards a more balanced pattern, away from enmeshment and @entity2003 . According to self-ratings, the families changed toward more expressiveness. Families where the @entity1 had recovered were less enmeshed at follow-up. We also found a tendency towards higher degree of competence in these families.

title: XXXX in teenagers: change in family function after family therapy, at 2-year follow-up.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'child']

entities_list: @entity1278 :: ('MESH:D000856', 'Disease') :: ['anorexia nervosa']

answer: @entity1278 :: (MESH:D000856,Disease) :: ['Anorexia nervosa']


abstract: OBJECTIVES: To examine the safety and efficacy of anhydrous crystalline @entity7969 for treatment of @entity2133 and other symptoms of dryness in @entity1 with primary @entity244 . DESIGN: Anhydrous crystalline @entity7969 was delivered orally as a 200-mg lozenge given three times daily over a 24-week period to a total of 100 subjects. All @entity1 had prominent complaints of persistent @entity2133 associated with primary @entity244 . @entity1 were examined at baseline and every 6 weeks of treatment. SETTINGS: @entity1 were seen in outpatient clinics at a total of 27 sites within the United States. OUTCOME MEASURES: Unstimulated whole saliva output, a measure of basal salivary gland function, was determined at each visit. Symptoms associated with oral and ocular dryness were assessed at the same time with the use of 100-mm visual analogue scales. Safety was assessed by physical examination and laboratory studies. RESULTS: During this clinical trial, a majority of evaluable subjects (39/76) demonstrated an increase in unstimulated whole saliva output, and the treatment exhibited an excellent safety profile. The anhydrous crystalline @entity7969 treatment led to significant improvement in several subjective measures of oral and ocular comfort. CONCLUSIONS: In this study, anhydrous crystalline @entity7969 lozenges administered three times daily for 24 weeks improved salivary output and decreased complaints of @entity2133 and eyes in @entity1 with primary @entity244 . Side-effects were minimal, and treatment was without significant adverse events. These results are similar to the benefits observed in two prior studies reported by the authors. This safe and simple intervention appears to provide clinical benefit to primary @entity244 @entity1 with distressing @entity2133 .

title: A third study on the use of orally administered anhydrous crystalline @entity7969 for relief of @entity2133 in primary XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['dry mouth', 'dry mouth symptoms']

entities_list: @entity244 :: ('MESH:D014899', 'Disease') :: ["Sj  gren's syndrome"]

answer: @entity244 :: (MESH:D014899,Disease) :: ['Sj  gren's syndrome']


abstract: OBJECTIVES: To examine the safety and efficacy of anhydrous crystalline @entity7969 for treatment of @entity2133 and other symptoms of dryness in @entity1 with primary @entity244 . DESIGN: Anhydrous crystalline @entity7969 was delivered orally as a 200-mg lozenge given three times daily over a 24-week period to a total of 100 subjects. All @entity1 had prominent complaints of persistent @entity2133 associated with primary @entity244 . @entity1 were examined at baseline and every 6 weeks of treatment. SETTINGS: @entity1 were seen in outpatient clinics at a total of 27 sites within the United States. OUTCOME MEASURES: Unstimulated whole saliva output, a measure of basal salivary gland function, was determined at each visit. Symptoms associated with oral and ocular dryness were assessed at the same time with the use of 100-mm visual analogue scales. Safety was assessed by physical examination and laboratory studies. RESULTS: During this clinical trial, a majority of evaluable subjects (39/76) demonstrated an increase in unstimulated whole saliva output, and the treatment exhibited an excellent safety profile. The anhydrous crystalline @entity7969 treatment led to significant improvement in several subjective measures of oral and ocular comfort. CONCLUSIONS: In this study, anhydrous crystalline @entity7969 lozenges administered three times daily for 24 weeks improved salivary output and decreased complaints of @entity2133 and eyes in @entity1 with primary @entity244 . Side-effects were minimal, and treatment was without significant adverse events. These results are similar to the benefits observed in two prior studies reported by the authors. This safe and simple intervention appears to provide clinical benefit to primary @entity244 @entity1 with distressing @entity2133 .

title: A third study on the use of orally administered anhydrous crystalline XXXX for relief of @entity2133 in primary @entity244 .

answer: @entity7969 :: (MESH:D008320,Chemical) :: ['maltose']


abstract: OBJECTIVES: To examine the safety and efficacy of anhydrous crystalline @entity7969 for treatment of @entity2133 and other symptoms of dryness in @entity1 with primary @entity244 . DESIGN: Anhydrous crystalline @entity7969 was delivered orally as a 200-mg lozenge given three times daily over a 24-week period to a total of 100 subjects. All @entity1 had prominent complaints of persistent @entity2133 associated with primary @entity244 . @entity1 were examined at baseline and every 6 weeks of treatment. SETTINGS: @entity1 were seen in outpatient clinics at a total of 27 sites within the United States. OUTCOME MEASURES: Unstimulated whole saliva output, a measure of basal salivary gland function, was determined at each visit. Symptoms associated with oral and ocular dryness were assessed at the same time with the use of 100-mm visual analogue scales. Safety was assessed by physical examination and laboratory studies. RESULTS: During this clinical trial, a majority of evaluable subjects (39/76) demonstrated an increase in unstimulated whole saliva output, and the treatment exhibited an excellent safety profile. The anhydrous crystalline @entity7969 treatment led to significant improvement in several subjective measures of oral and ocular comfort. CONCLUSIONS: In this study, anhydrous crystalline @entity7969 lozenges administered three times daily for 24 weeks improved salivary output and decreased complaints of @entity2133 and eyes in @entity1 with primary @entity244 . Side-effects were minimal, and treatment was without significant adverse events. These results are similar to the benefits observed in two prior studies reported by the authors. This safe and simple intervention appears to provide clinical benefit to primary @entity244 @entity1 with distressing @entity2133 .

title: A third study on the use of orally administered anhydrous crystalline @entity7969 for relief of XXXX in primary @entity244 .

answer: @entity2133 :: (MESH:D014987,Disease) :: ['dry mouth']


abstract: OBJECTIVE: Holter monitoring is one option in risk-stratification after acute @entity583 ( @entity583 ). Measurements of heart rate variability (HRV), @entity1165 ( @entity1165 ) and ST-segment elevation (ST upward arrow ) have been useful in predicting clinical outcome. We investigated if a combination of different Holter variables could optimize risk-stratification. DESIGN: One hundred and twenty-one @entity1 < 70 years old with a first @entity583 were studied. Holter monitoring for 24 h was started 11 +/- 5 days after @entity583 and analysed for HRV, @entity1165 and ST. Follow-up was 10-12 years with @entity204 as endpoint. RESULTS: Thirty-six @entity1 were positive for > or = 1 Holter variable (HRV in 15, @entity1165 in 16, ST in 10). At follow-up 22 @entity204 had occurred. The prognostic sensitivity of individual Holter variables ranged from 23 to 36%, but increased to 64% if combined. The @entity204 rate in Holter positive @entity1 (39%) was significantly higher than in Holter negative @entity1 (9%) (p < 0.0001). CONCLUSION: By combining measurements of HRV, @entity1165 and ST the prognostic importance of Holter monitoring can be significantly improved. The @entity1 can be stratified in a low-risk group with an annual mortality < 1% vs a high-risk group with a @entity204 rate around 40% over the following decade.

title: Improvement of risk-stratification by use of a new combination of Holter variables in survivors of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death', 'cardiac deaths']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: OBJECTIVE: An increase in intracranial pressure has been shown to threaten the outcome of @entity1 with @entity63 or traumatic @entity1545 . Its impact on the outcome of @entity1707 undergoing hypothermic @entity1167 has been evaluated in this study. DESIGN: Fifty-six @entity1707 underwent a 75-min period of hypothermic @entity1167 at 20 degrees C. Intracranial pressure, cerebral microdialysis, hemodynamic and metabolic parameters were monitored throughout the experiment. The animals were allowed to survive until the 7th postoperative day and, then, electively killed. RESULTS: The 7-day survival rate was 60.7%, and among survivors, 20 of them (58.8%) developed @entity4798 . A significant increase in intracranial pressure as compared with the baseline level was observed since the end of cooling (p = 0.047) and the difference became larger during all the postoperative intervals (p < 0.0001). Animals that died postoperatively tended to have higher intracranial pressure levels during all the postoperative intervals, but such a difference reached significance only at the 4-h postoperative interval (p = 0.040). The same tendency was observed among animals that survived until the 7th postoperative day and that developed @entity4798 or not, but the difference between these two groups did not reach statistical significance. The animals that died or developed postoperatively @entity4798 had higher intracranial pressure values postoperatively as compared with those that survived without developing @entity4798 and such a difference reached significance at the 2-h (p = 0.015) and 4-h postoperative intervals (p = 0.035). The peak intracranial pressure was 17.2 mmHg (IQR, 13.7-20.8) in animals that died or developed @entity4798 and 14.1 mmHg (IQR, 11.8-16.4) in those that survived 7 days without developing @entity4798 (p = NS). CONCLUSION: Intracranial pressure increases significantly after 75 min of experimental hypothermic @entity1167 and such an increase is associated with a high risk of @entity204 and @entity4798 .

title: Increase of intracranial pressure after hypothermic XXXX in a chronic porcine model.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity4798 :: ('MESH:D020520', 'Disease') :: ['brain infarction']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['circulatory arrest']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['postoperative death']

answer: @entity1167 :: (MESH:D006323,Disease) :: ['circulatory arrest']


abstract: BACKGROUND: Aortobifemoral bypass grafting is the treatment of choice for @entity1 with symptomatic @entity432 . Yet, traditional operative exposure through a midline laparotomy incision carries significant morbidity. The authors compare operative and @entity1 outcomes following @entity8566 ( @entity8566 ) bypass and @entity1538 ( @entity1538 ) bypass. METHODS: An initial series of @entity1 who underwent @entity8566 bypass grafting (n = 8) were compared with a simultaneous cohort of @entity1 treated with standard open bypass (n = 10). The two groups were similar with respect to age, weight, and sex. Operative parameters, clinical outcomes, and complications were compared. RESULTS: @entity8566 was successfully performed in all eight cases attempted. Operative times did not differ between the laparoscopic and open groups (234 +/- 42 minutes vs. 206 +/- 43 minutes, P =.99). Mean @entity190 values were comparable (562 mL [ @entity8566 ] vs. 756 mL [ @entity1538 ], P =.56). There were no conversions. Time to resumption of oral intake (1.8 vs. 4.7 days, P =.001) and length of stay (3.8 vs. 6.3 days, P =.0004) were significantly shorter in the laparoscopic than in the open group. CONCLUSIONS: @entity8566 is a safe and technically feasible procedure. When compared with the traditional open operation, this technique may result in shorter hospitalization, more rapid return of bowel function, and earlier return to activity.

title: Hand-assisted laparoscopic aortobifemoral bypass versus open bypass for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1538 :: ('MESH:D005902', 'Disease') :: ['open aortobifemoral', 'OABF']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity8566 :: ('MESH:D060831', 'Disease') :: ['HALABF', 'hand-assisted laparoscopic aortobifemoral']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['aortoiliac occlusive disease']

answer: @entity432 :: (MESH:D001157,Disease) :: ['occlusive disease']


abstract: PURPOSE: Recurrent or persistent @entity2687 and @entity1066 are typical complications of @entity9849 . Toxic eosinophil granule proteins such as major basic protein ( @entity2610 ) and @entity11153 ( @entity11153 ) may be involved in this pathogenetic process. This study was designed to demonstrate the presence of toxic eosinophil granule proteins in corneal tissue from a @entity1 with corneal complications of @entity9849 . DESIGN: Observational case report. METHODS: Three corneal buttons of a @entity1 with @entity9849 associated @entity1066 or scarring were examined by light microscopy and by immunofluorescence technique. RESULTS: A linear deposition of eosinophil granular substance was detected subepithelially above Bowman's membrane in all corneal buttons. Indirect immunofluorescence identified this material as @entity2610 and @entity11153 . The deposits were not limited to the area of ulceration, but were also found underneath intact corneal epithelium. Multiple eosinophils were present in the upper @entity2687 . Normal corneas and negative control sections of the pathologic buttons revealed only minimal nonspecific staining at the surface of the epithelium. CONCLUSIONS: Both @entity2610 and @entity11153 are known to affect @entity1 corneal epithelial cell viability and morphology in vitro. Moreover, @entity2610 was shown to inhibit epithelial migration and protein synthesis. These toxic eosinophil proteins may also be responsible for corneal instability, recurrent and persistent corneal epithelial defects and @entity1066 in @entity1 with @entity9849 .

title: Toxic eosinophil granule protein deposition in corneal XXXX and scars associated with @entity9849 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity11153 :: ('6037', 'Gene') :: ['eosinophil cationic protein', 'ECP']

entities_list: @entity9849 :: ('MESH:D007637', 'Disease') :: ['atopic keratoconjunctivitis']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcerations']

entities_list: @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal erosions', 'corneal stroma']

answer: @entity1066 :: (MESH:D014456,Disease) :: ['ulcerations']


abstract: PURPOSE: Recurrent or persistent @entity2687 and @entity1066 are typical complications of @entity9849 . Toxic eosinophil granule proteins such as major basic protein ( @entity2610 ) and @entity11153 ( @entity11153 ) may be involved in this pathogenetic process. This study was designed to demonstrate the presence of toxic eosinophil granule proteins in corneal tissue from a @entity1 with corneal complications of @entity9849 . DESIGN: Observational case report. METHODS: Three corneal buttons of a @entity1 with @entity9849 associated @entity1066 or scarring were examined by light microscopy and by immunofluorescence technique. RESULTS: A linear deposition of eosinophil granular substance was detected subepithelially above Bowman's membrane in all corneal buttons. Indirect immunofluorescence identified this material as @entity2610 and @entity11153 . The deposits were not limited to the area of ulceration, but were also found underneath intact corneal epithelium. Multiple eosinophils were present in the upper @entity2687 . Normal corneas and negative control sections of the pathologic buttons revealed only minimal nonspecific staining at the surface of the epithelium. CONCLUSIONS: Both @entity2610 and @entity11153 are known to affect @entity1 corneal epithelial cell viability and morphology in vitro. Moreover, @entity2610 was shown to inhibit epithelial migration and protein synthesis. These toxic eosinophil proteins may also be responsible for corneal instability, recurrent and persistent corneal epithelial defects and @entity1066 in @entity1 with @entity9849 .

title: Toxic eosinophil granule protein deposition in corneal @entity1066 and scars associated with XXXX .

answer: @entity9849 :: (MESH:D007637,Disease) :: ['atopic keratoconjunctivitis']


abstract: @entity301 ( @entity301 ) risk factors affect a large proportion of European adult populations; hence most @entity301 results from the exposure of many @entity1 to moderately elevated risk factor levels. The population strategy is directed to improving the health-related behaviour of the entire population, by means of mass education and administrative measures aimed at nutrition, smoking and exercise; these measures are reviewed in some detail. This approach is inadequate for minimising risk in the minority in whom pronounced risk factor levels are present (e.g. major forms of hyperlipidaemia); such @entity1 require individual therapy in a clinical setting, i.e. an individual strategy. The @entity731 Society (EAS) endorses both strategies and regards them as complementary. It advocates a case-finding approach to identifying those @entity1 requiring individual care. Although lipid risk factors, like blood pressure, are continuous variables, the EAS has defined action limits for plasma @entity165 , @entity412 and HDL- @entity165 concentrations; the interpretation of these is influenced by the presence and extent of other risk factors and of @entity65 , and by age and sex. Recently the EAS has produced guidelines on the recognition and treatment of hyperlipidaemia. These provide sufficient step by step detail to permit the effective, safe management of most hyperlipidaemic @entity1 by the non-specialised physician, with advice on dietary and drug therapies, and the investigation and management of all major forms of hyperlipidaemia. The main features of these guidelines are described in this paper.

title: Population and individual strategies for the prevention of XXXX . Policy of the @entity731 Society.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people', 'persons']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'Coronary heart disease']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['European Atherosclerosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity301 :: (MESH:D003327,Disease) :: ['coronary heart disease']


abstract: @entity301 ( @entity301 ) risk factors affect a large proportion of European adult populations; hence most @entity301 results from the exposure of many @entity1 to moderately elevated risk factor levels. The population strategy is directed to improving the health-related behaviour of the entire population, by means of mass education and administrative measures aimed at nutrition, smoking and exercise; these measures are reviewed in some detail. This approach is inadequate for minimising risk in the minority in whom pronounced risk factor levels are present (e.g. major forms of hyperlipidaemia); such @entity1 require individual therapy in a clinical setting, i.e. an individual strategy. The @entity731 Society (EAS) endorses both strategies and regards them as complementary. It advocates a case-finding approach to identifying those @entity1 requiring individual care. Although lipid risk factors, like blood pressure, are continuous variables, the EAS has defined action limits for plasma @entity165 , @entity412 and HDL- @entity165 concentrations; the interpretation of these is influenced by the presence and extent of other risk factors and of @entity65 , and by age and sex. Recently the EAS has produced guidelines on the recognition and treatment of hyperlipidaemia. These provide sufficient step by step detail to permit the effective, safe management of most hyperlipidaemic @entity1 by the non-specialised physician, with advice on dietary and drug therapies, and the investigation and management of all major forms of hyperlipidaemia. The main features of these guidelines are described in this paper.

title: Population and individual strategies for the prevention of @entity301 . Policy of the XXXX Society.

answer: @entity731 :: (MESH:D050197,Disease) :: ['European Atherosclerosis']


abstract: Experimental studies indicate significant cardioprotective effects of recombinant @entity14190 ( @entity14190 ) by binding to the @entity14191 ( @entity14191 ) and by inducing various molecular mechanisms, including activation of @entity7006 , a transcription factor that induces anti-apoptotic genes. However, specific molecular mechanisms of @entity14191 regulation in cardiomyocytes are unknown. We identified a 774 bp regulatory domain in the @entity14191 5' flanking region by reporter gene assays in @entity19 HL-1 cardiomyocytes. The binding sites for @entity41551 and Sp transcription factors both significantly contributed to @entity14191 promoter activity. DNA-binding studies (EMSA and ChIP assays) identified @entity7006 and @entity10591 as @entity14191 promoter-binding proteins in @entity36461 cardiomyocytes. Although @entity10591 alone stimulates @entity14191 only slightly, forced expression of @entity7006 significantly induced @entity14191 mRNA expression. In addition, knockdown of @entity7006 (but also of @entity10591 ) resulted in a significant decrease of @entity14191 transcript levels in HL-1 cardiomyocytes. Cumulative in vitro data suggest that function of the @entity10591 site is essential for the @entity7006 -mediated transcription. In vivo, analysis of @entity19 expressing an inducible small-hairpin RNA against @entity7006 confirmed suppression of @entity14191 expression in the heart. Treating @entity19 with high-dose @entity632 not only resulted in @entity7006 protein depletion, but also down-regulated @entity14191 , followed by up-regulation of @entity14191 transcripts when @entity7006 levels recovered. In conclusion, we identified @entity7006 as novel regulator of @entity14191 transcription in cardiomyocytes. In models of @entity299 , down-regulation of @entity7006 or @entity10591 may limit the accessibility of the @entity14191 for binding of erythropoiesis-stimulating agents (ESA). Thereby our data underline the essential role of @entity7006 in mediating cardioprotective effects.

title: XXXX and @entity10591 regulate expression of the @entity14190 receptor in cardiomyocytes.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity19 :: ('10090', 'Species') :: ['mice', 'transgenic mice', 'murine']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac injury']

answer: @entity7006 :: (14463(Tax:10090),Gene) :: ['Gata4']


abstract: Experimental studies indicate significant cardioprotective effects of recombinant @entity14190 ( @entity14190 ) by binding to the @entity14191 ( @entity14191 ) and by inducing various molecular mechanisms, including activation of @entity7006 , a transcription factor that induces anti-apoptotic genes. However, specific molecular mechanisms of @entity14191 regulation in cardiomyocytes are unknown. We identified a 774 bp regulatory domain in the @entity14191 5' flanking region by reporter gene assays in @entity19 HL-1 cardiomyocytes. The binding sites for @entity41551 and Sp transcription factors both significantly contributed to @entity14191 promoter activity. DNA-binding studies (EMSA and ChIP assays) identified @entity7006 and @entity10591 as @entity14191 promoter-binding proteins in @entity36461 cardiomyocytes. Although @entity10591 alone stimulates @entity14191 only slightly, forced expression of @entity7006 significantly induced @entity14191 mRNA expression. In addition, knockdown of @entity7006 (but also of @entity10591 ) resulted in a significant decrease of @entity14191 transcript levels in HL-1 cardiomyocytes. Cumulative in vitro data suggest that function of the @entity10591 site is essential for the @entity7006 -mediated transcription. In vivo, analysis of @entity19 expressing an inducible small-hairpin RNA against @entity7006 confirmed suppression of @entity14191 expression in the heart. Treating @entity19 with high-dose @entity632 not only resulted in @entity7006 protein depletion, but also down-regulated @entity14191 , followed by up-regulation of @entity14191 transcripts when @entity7006 levels recovered. In conclusion, we identified @entity7006 as novel regulator of @entity14191 transcription in cardiomyocytes. In models of @entity299 , down-regulation of @entity7006 or @entity10591 may limit the accessibility of the @entity14191 for binding of erythropoiesis-stimulating agents (ESA). Thereby our data underline the essential role of @entity7006 in mediating cardioprotective effects.

title: @entity7006 and @entity10591 regulate expression of the XXXX receptor in cardiomyocytes.

answer: @entity14190 :: (13856(Tax:10090),Gene) :: ['erythropoietin']


abstract: Experimental studies indicate significant cardioprotective effects of recombinant @entity14190 ( @entity14190 ) by binding to the @entity14191 ( @entity14191 ) and by inducing various molecular mechanisms, including activation of @entity7006 , a transcription factor that induces anti-apoptotic genes. However, specific molecular mechanisms of @entity14191 regulation in cardiomyocytes are unknown. We identified a 774 bp regulatory domain in the @entity14191 5' flanking region by reporter gene assays in @entity19 HL-1 cardiomyocytes. The binding sites for @entity41551 and Sp transcription factors both significantly contributed to @entity14191 promoter activity. DNA-binding studies (EMSA and ChIP assays) identified @entity7006 and @entity10591 as @entity14191 promoter-binding proteins in @entity36461 cardiomyocytes. Although @entity10591 alone stimulates @entity14191 only slightly, forced expression of @entity7006 significantly induced @entity14191 mRNA expression. In addition, knockdown of @entity7006 (but also of @entity10591 ) resulted in a significant decrease of @entity14191 transcript levels in HL-1 cardiomyocytes. Cumulative in vitro data suggest that function of the @entity10591 site is essential for the @entity7006 -mediated transcription. In vivo, analysis of @entity19 expressing an inducible small-hairpin RNA against @entity7006 confirmed suppression of @entity14191 expression in the heart. Treating @entity19 with high-dose @entity632 not only resulted in @entity7006 protein depletion, but also down-regulated @entity14191 , followed by up-regulation of @entity14191 transcripts when @entity7006 levels recovered. In conclusion, we identified @entity7006 as novel regulator of @entity14191 transcription in cardiomyocytes. In models of @entity299 , down-regulation of @entity7006 or @entity10591 may limit the accessibility of the @entity14191 for binding of erythropoiesis-stimulating agents (ESA). Thereby our data underline the essential role of @entity7006 in mediating cardioprotective effects.

title: @entity7006 and XXXX regulate expression of the @entity14190 receptor in cardiomyocytes.

answer: @entity10591 :: (20683(Tax:10090),Gene) :: ['Sp1']


abstract: Recent data indicate that phagocytosis mediated by FcgammaRs is controlled by the @entity7242 and @entity10255 families of protein @entity669 kinases. In this study, we demonstrate a sequential involvement of @entity18226 and @entity10255 in the phagocytosis of IgG-coated particles. The particles isolated at the stage of their binding to FcgammaRs (4 degrees C) were accompanied by high amounts of @entity18226 , in addition to the signaling gamma-chain of FcgammaRs. Simultaneously, the particle binding induced rapid @entity669 phosphorylation of numerous proteins. During synchronized internalization of the particles induced by shifting the cell to 37 degrees C, @entity10255 kinase and @entity7242 homology 2-containing @entity669 phosphatase-1 ( @entity46999 ) were associated with the formed phagosomes. At this step, most of the proteins were dephosphorylated, although some underwent further @entity669 phosphorylation. Quantitative immunoelectron microscopy studies confirmed that @entity18226 accumulated under the plasma membrane beneath the bound particles. High amounts of the gamma-chain and @entity669 -phosphorylated proteins were also observed under the bound particles. When the particles were internalized, the gamma-chain was still detected in the region of the phagosomes, while amounts of @entity18226 were markedly reduced. In contrast, the vicinity of the phagosomes was heavily decorated with anti- @entity10255 and anti- @entity46999 Abs. The local level of protein @entity669 phosphorylation was reduced. The data indicate that the accumulation of @entity18226 during the binding of IgG-coated particles to FcgammaRs correlated with strong @entity669 phosphorylation of numerous proteins, suggesting an initiating role for @entity18226 in protein phosphorylation at the onset of the phagocytosis. @entity10255 kinase and @entity46999 phosphatase are mainly engaged at the stage of particle internalization.

title: @entity18226 and XXXX kinases are sequentially engaged in phagocytosis mediated by Fc gamma R.

entities_list: @entity669 :: ('CHEBI:18186', 'Chemical') :: ['tyrosine']

answer: @entity10255 :: (6850,Gene) :: ['Syk']


abstract: Recent data indicate that phagocytosis mediated by FcgammaRs is controlled by the @entity7242 and @entity10255 families of protein @entity669 kinases. In this study, we demonstrate a sequential involvement of @entity18226 and @entity10255 in the phagocytosis of IgG-coated particles. The particles isolated at the stage of their binding to FcgammaRs (4 degrees C) were accompanied by high amounts of @entity18226 , in addition to the signaling gamma-chain of FcgammaRs. Simultaneously, the particle binding induced rapid @entity669 phosphorylation of numerous proteins. During synchronized internalization of the particles induced by shifting the cell to 37 degrees C, @entity10255 kinase and @entity7242 homology 2-containing @entity669 phosphatase-1 ( @entity46999 ) were associated with the formed phagosomes. At this step, most of the proteins were dephosphorylated, although some underwent further @entity669 phosphorylation. Quantitative immunoelectron microscopy studies confirmed that @entity18226 accumulated under the plasma membrane beneath the bound particles. High amounts of the gamma-chain and @entity669 -phosphorylated proteins were also observed under the bound particles. When the particles were internalized, the gamma-chain was still detected in the region of the phagosomes, while amounts of @entity18226 were markedly reduced. In contrast, the vicinity of the phagosomes was heavily decorated with anti- @entity10255 and anti- @entity46999 Abs. The local level of protein @entity669 phosphorylation was reduced. The data indicate that the accumulation of @entity18226 during the binding of IgG-coated particles to FcgammaRs correlated with strong @entity669 phosphorylation of numerous proteins, suggesting an initiating role for @entity18226 in protein phosphorylation at the onset of the phagocytosis. @entity10255 kinase and @entity46999 phosphatase are mainly engaged at the stage of particle internalization.

title: XXXX and @entity10255 kinases are sequentially engaged in phagocytosis mediated by Fc gamma R.

answer: @entity18226 :: (4067,Gene) :: ['Lyn']


abstract: The purpose of this study was to assess stability of @entity146 across time. 29 @entity1 were seen at both 9 and 9.5 mo.; 20 of these @entity1 were seen again at 12 mo. At each visit the @entity1 were presented several objects for familiarization and tested for response to discrepant objects. Each trial was scored for the duration of looking, rotating the object, fingering, mouthing, and banging, the frequency of transferring the object from hand to hand, and the frequency of dropping, throwing and pushing the object away. Analysis of the data yielded moderate to high correlations between 9 and 9.5 mo. for all but one behavior. Correlations between 9 and 12 mo. were in the same range for most of the behaviors. On the test trials, there were fewer significant correlations. When the behaviors were separated into exploratory and nonexploratory categories, there was more stability for the nonexploratory behaviors; summary scores for both were concurrently related to Bayley Mental Development Index at 12 mo., but in opposite directions. The results suggest that there is stability in some @entity146 , and further, that it is useful to conceptualize two types of @entity146 .

title: Stability of individual differences in XXXX ' manipulation and exploration of objects.

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['manipulative behaviors', 'manipulative behavior']

answer: @entity1 :: (9606,Species) :: ['infants']


abstract: We report two cases of @entity1829 in young @entity1 . The first @entity1 was 15 years old and had experienced @entity10 and @entity391 for one month, but no @entity227 . Cerebral tomodensitometry results were normal, but lumbar puncture showed increased pressure and normal biology. Benign intracranial @entity101 was diagnosed. Recent treatment with @entity1214 for acne @entity6248 was the only etiology. @entity1829 was totally regressed at 6 weeks, after interruption of the antibiotic treatment. A prescription of @entity3791 was added for a short period of 10 days. The second @entity1 , aged 29 years, presented @entity1829 with severe @entity227 , with vision limited to light perception with @entity5564 of the right eye. Lumbar puncture was not indicated because of a hypophyseal microadenoma revealed on MRI investigation. No other associated abnormalities were observed, in particular, no @entity50 . Corticotherapy using @entity617 for 72 hours had no clinical effect. Fast visual recovery was obtained with intravenous @entity3791 therapy and was completely resolved at 2 months. Right @entity227 persisted. @entity1214 and @entity28 are recognized as precipitating factors in @entity5576 . The literature advocates consideration of surgical treatment by optic nerve sheath fenestration if antiedematous treatment has no effect and the eye is nearly blind.

title: [Bilateral XXXX in young @entity1 : two case reports of @entity5576 ?].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'visual field defects']

entities_list: @entity1214 :: ('MESH:D008911', 'Chemical') :: ['Minocycline', 'minocycline']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity3791 :: ('MESH:D000086', 'Chemical') :: ['acetazolamide']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1829 :: ('MESH:D010211', 'Disease') :: ['bilateral papilledema', 'Papilledema']

entities_list: @entity5564 :: ('MESH:D015878', 'Disease') :: ['mydriasis']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headaches']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['cerebral sinus thrombosis']

entities_list: @entity5576 :: ('MESH:D011559', 'Disease') :: ['pseudotumor cerebri syndrome']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

answer: @entity1829 :: (MESH:D010211,Disease) :: ['papilledema']


abstract: We report two cases of @entity1829 in young @entity1 . The first @entity1 was 15 years old and had experienced @entity10 and @entity391 for one month, but no @entity227 . Cerebral tomodensitometry results were normal, but lumbar puncture showed increased pressure and normal biology. Benign intracranial @entity101 was diagnosed. Recent treatment with @entity1214 for acne @entity6248 was the only etiology. @entity1829 was totally regressed at 6 weeks, after interruption of the antibiotic treatment. A prescription of @entity3791 was added for a short period of 10 days. The second @entity1 , aged 29 years, presented @entity1829 with severe @entity227 , with vision limited to light perception with @entity5564 of the right eye. Lumbar puncture was not indicated because of a hypophyseal microadenoma revealed on MRI investigation. No other associated abnormalities were observed, in particular, no @entity50 . Corticotherapy using @entity617 for 72 hours had no clinical effect. Fast visual recovery was obtained with intravenous @entity3791 therapy and was completely resolved at 2 months. Right @entity227 persisted. @entity1214 and @entity28 are recognized as precipitating factors in @entity5576 . The literature advocates consideration of surgical treatment by optic nerve sheath fenestration if antiedematous treatment has no effect and the eye is nearly blind.

title: [Bilateral @entity1829 in young @entity1 : two case reports of XXXX ?].

answer: @entity5576 :: (MESH:D011559,Disease) :: ['benign intracranial hypertension']


abstract: We report two cases of @entity1829 in young @entity1 . The first @entity1 was 15 years old and had experienced @entity10 and @entity391 for one month, but no @entity227 . Cerebral tomodensitometry results were normal, but lumbar puncture showed increased pressure and normal biology. Benign intracranial @entity101 was diagnosed. Recent treatment with @entity1214 for acne @entity6248 was the only etiology. @entity1829 was totally regressed at 6 weeks, after interruption of the antibiotic treatment. A prescription of @entity3791 was added for a short period of 10 days. The second @entity1 , aged 29 years, presented @entity1829 with severe @entity227 , with vision limited to light perception with @entity5564 of the right eye. Lumbar puncture was not indicated because of a hypophyseal microadenoma revealed on MRI investigation. No other associated abnormalities were observed, in particular, no @entity50 . Corticotherapy using @entity617 for 72 hours had no clinical effect. Fast visual recovery was obtained with intravenous @entity3791 therapy and was completely resolved at 2 months. Right @entity227 persisted. @entity1214 and @entity28 are recognized as precipitating factors in @entity5576 . The literature advocates consideration of surgical treatment by optic nerve sheath fenestration if antiedematous treatment has no effect and the eye is nearly blind.

title: [Bilateral @entity1829 in young XXXX : two case reports of @entity5576 ?].

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND: The authors report their initial experience with partial and total thyroidectomy, and neck exploration for @entity2742 using the video-assisted approach. @entity1 AND METHODS: Between June 1999 and March 2001, 114 @entity1 underwent a thyroid (n = 57) or @entity3243 (n = 57) operation using a video-assisted cervical approach. Video-assisted neck exploration was conducted in all cases under general anaesthesia leading to a partial or total thyroidectomy, and to a selective adenoma removal in PHPT or to a subtotal @entity3243 resection in SHPT. RESULTS: IN THE THYROID GROUP: The mean cranio-caudal and transversal diameter of the resected specimen were respectively 4.9 +/- 0.9 and 2.8 +/- 0.6 cm, and mean total lobar weight was 11.7 +/- 5.8 g. Conversion to conventional surgery was required in 5 @entity1 (8.8%). The mean operative time was 133.9 +/- 26.9 and 86.5 +/- 22.5 minutes for total and partial thyroidectomy respectively. The laryngeal nerve was identified in 96% of cases. The mean length of skin incision was 24.0 +/- 2 mm. There were 3 cases of postoperative @entity3747 , and 2 cases of postoperative hoarseness. The postoperative hospital stay was less than 24 hours for 72.7% of @entity1 . The @entity158 intensity at day one (VAS) was 2.1 +/- 1.3. IN THE PARATHYROID GROUP: Seven of the 44 @entity1 who underwent PHPT (15.9%) and 4 of the 13 @entity1 who underwent surgery for SHPT (30.8%) were converted to a conventional surgical technique. The mean operative time in PHPT and SHPT was 47.3 +/- 22.3 minutes and 136.8 +/- 18.7 minutes, respectively. Recurrent laryngeal nerve was identified in 53.1% of the @entity1 . The median diameter and weight of the resected @entity3243 glands were 1.5 cm (range 0.8-2.7) and 0.9 g (range 0.5-7), respectively. The length of skin incision was 24 +/- 2 mm. All but 2 @entity1 are currently cured. Postoperative complications included @entity1410 and transient hoarseness each in one @entity1 (1.75%). The median @entity158 intensity at day one (VAS) was 0.5 (range: 0 to 3.6). In the PHPT group, the postoperative hospital stay was less than 24 hours for 56.7% of the @entity1 , and less than 48 hours for 91.9% of them. CONCLUSION: The video-assisted approach for thyroid and @entity3243 surgery is feasible, safe and effective in selected cases. Benefits for the @entity1 should be further assessed in future prospective comparative trials.

title: Contributions of the video-assisted approach to thyroid and XXXX surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity3747 :: ('MESH:D006996', 'Disease') :: ['hypocalcemia']

entities_list: @entity3243 :: ('MESH:D010282', 'Disease') :: ['parathyroid']

entities_list: @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism']

answer: @entity3243 :: (MESH:D010282,Disease) :: ['parathyroid']


abstract: 1. The effects of @entity934 ( @entity1617 ) on developed @entity2701 and intracellular @entity141 concentration (as measured with aequorin) were studied in ferret papillary muscles, and on twitch shortening, the action potential and membrane currents in ferret ventricular myocytes. 2. Addition of @entity1617 to ferret papillary muscles resulted in decreases in developed @entity2701 and the intracellular @entity141 transient, both of which then partially recovered in the continued presence of @entity1617 ('fade' of the response). On wash-off of @entity1617 both developed @entity2701 and the intracellular @entity141 transient increased above control ('rebound') before returning to control values. 3. Addition of @entity1617 to ferret ventricular myocytes resulted in a membrane hyperpolarization of 2 +/- 0.5 mV (mean +/- S.E.M.; n = 9), a decrease in action potential duration to 23 +/- 6% of control and a decrease in twitch shortening to 31 +/- 5% of control. In the continued presence of @entity1617 these responses to @entity1617 faded. Thirty seconds after the maximal effect of @entity1617 , action potential duration had partially recovered to 34 +/- 6% of control and twitch shortening to 46 +/- 7% of control. 4. The effects of @entity1617 on twitch shortening could be mimicked under voltage clamp by varying voltage clamp pulse duration to simulate the @entity1617 -induced changes in action potential duration. 5. When @entity1617 was applied during a train of voltage clamp pulses of constant duration, 81% of the cells showed less than a 20% decrease in @entity141 current and twitch shortening. However in 19% of the cells twitch shortening and the apparent @entity141 current decreased by more than 30%. 6. In the 81% of cells, the normal decrease in twitch shortening was wholly the result of the shortening of the action potential. This in turn was the result of an increase in an outward background current which increased the rate of repolarization during the action potential. The @entity1617 -induced background current reversed at -89 +/- 2 mV and showed inward-going rectification; these properties suggest that it was carried by K+. 7. In the 19% of cells, the normal decrease in twitch shortening was only partly the result of the shortening of the action potential (due to both the increase in outward background current as well as the apparent decrease in @entity141 current). In these cells the decrease in twitch shortening may also have been partly the direct result of the apparent decrease of @entity141 current.

title: The negative inotropic effect of XXXX on ferret ventricular myocardium.

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity934 :: (MESH:D000109,Chemical) :: ['acetylcholine']


abstract: It has been suggested that @entity2730 @entity1 suffer a selective loss of episodic memory while semantic memory remains well preserved. To assess the validity of this idea we studied remote memory in an @entity2730 @entity1 , (M.R.L.), using several different measures that differ in the extent to which they engage episodic or semantic memory. On two different versions of the Albert et al. (1979) remote memory battery M.R.L. displayed severe @entity5186 ( @entity5186 ) extending backwards in time for about 15 years with excellent preservation of older memories. With standard recall instructions his overall performance on the Crovitz test of autobiographical memory was impaired and all of M.R.L.'s specific, temporally dated memories were given from the first half of his life. When asked to reconstruct his past residential history in detail, M.R.L. provide specific and generally accurate information for residences occupied from his boyhood until 1970, but thereafter his memory became quite unreliable. On a test of knowledge of terms commonly employed in the surveying profession, in which he worked for the past 20 years, M.R.L.'s performance was also impaired. The consistent pattern of @entity5186 displayed by this @entity1 on all of the tests of remote memory indicates that both @entity2414 are impaired in @entity2730 .

title: Remote memory in a @entity1 with XXXX due to hypoxia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['episodic and semantic memory']

entities_list: @entity5186 :: ('MESH:D000648', 'Disease') :: ['retrograde amnesia', 'RA']

entities_list: @entity2730 :: ('MESH:D000647', 'Disease') :: ['amnesia', 'amnesic']

answer: @entity2730 :: (MESH:D000647,Disease) :: ['amnesia']


abstract: It has been suggested that @entity2730 @entity1 suffer a selective loss of episodic memory while semantic memory remains well preserved. To assess the validity of this idea we studied remote memory in an @entity2730 @entity1 , (M.R.L.), using several different measures that differ in the extent to which they engage episodic or semantic memory. On two different versions of the Albert et al. (1979) remote memory battery M.R.L. displayed severe @entity5186 ( @entity5186 ) extending backwards in time for about 15 years with excellent preservation of older memories. With standard recall instructions his overall performance on the Crovitz test of autobiographical memory was impaired and all of M.R.L.'s specific, temporally dated memories were given from the first half of his life. When asked to reconstruct his past residential history in detail, M.R.L. provide specific and generally accurate information for residences occupied from his boyhood until 1970, but thereafter his memory became quite unreliable. On a test of knowledge of terms commonly employed in the surveying profession, in which he worked for the past 20 years, M.R.L.'s performance was also impaired. The consistent pattern of @entity5186 displayed by this @entity1 on all of the tests of remote memory indicates that both @entity2414 are impaired in @entity2730 .

title: Remote memory in a XXXX with @entity2730 due to hypoxia.

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: Extracts of 13 Brazilian medicinal plants were screened for their antimicrobial activity against bacteria and @entity375 . Of these, 10 plant extracts showed varied levels of antibacterial activity. Piper regnellii presented a good activity against @entity794 and @entity3881 , a moderate activity on @entity796 , and a weak activity against @entity526 . Punica granatum showed good activity on @entity794 and was inactive against the other standard strains. Eugenia uniflora presented moderate activity on both @entity794 and @entity526 . Psidium guajava,Tanacetum vulgare, Arctium lappa, Mikania glomerata, Sambucus canadensis, Plantago major and Erythrina speciosa presented some degree of antibacterial activity. Spilanthes acmella, @entity22035 were considered inactive. Five of the plant extracts presented compounds with Rf values similar to the antibacterial compounds visible on bioautogram. Of these, three plants belong to the Asteraceae family. This may mean that the same compounds are responsible for the antibacterial activity in these plants. Anticandidal activity was detected in nine plant extracts (P. guajava, E. uniflora, P. granatum, A. lappa, @entity3505 , M. glomerata, L. alba, P. regnellii, and @entity9855 ). The results might explain the ethnobotanical use of the studied species for the treatment of various @entity166 .

title: Screening of some plants used in the Brazilian folk medicine for the treatment of XXXX .

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa']

entities_list: @entity22035 :: ('MESH:D003741', 'Disease') :: ['Lippia alba, and Achillea millefolium']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococus aureus', 'S. aureus']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases']

entities_list: @entity3881 :: ('1423', 'Species') :: ['Bacillus subtilis']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity166 :: (MESH:D003141,Disease) :: ['infectious diseases']


abstract: BACKGROUND AND STUDY AIMS: Management options for @entity356 ( @entity5 ) include @entity5 removal or surveillance. If the latter is chosen, it requires repeated measurements of the @entity5 diameter. Although this can be achieved using endoscopy or endosonography (EUS), a less invasive and cheaper method would be welcome. The aim of this prospective study was to assess the proportion of gastric @entity5 that can be visualized using transabdominal ultrasound of the water-filled stomach. @entity1 AND METHODS: Fifty-one consecutive @entity1 with endosonographically diagnosed gastric @entity5 underwent transabdominal ultrasound examinations of the water-filled stomach performed immediately after EUS; both procedures were carried out by the same investigator. Transabdominal ultrasound was considered positive only if: firstly, the @entity5 was visualized unequivocally; secondly, its dimensions could be measured; and thirdly, photographic documentation could be recorded. In each case, a positive result had to be confirmed by an independent investigator, who reviewed the photographic documentation. RESULTS: The median size of @entity5 on EUS was 25 mm (range 4 - 55 mm). Twelve @entity5 were located in the antrum, 25 in the gastric body, and 14 in the gastric fundus or @entity418 . Transabdominal ultrasound demonstrated the @entity5 in 35 of 51 @entity1 (69 %). For @entity5 < or = 30 mm, the visualization rate was 61 % (22 of 36). The location of the @entity5 and its EUS features did not significantly affect the sensitivity of transabdominal ultrasound. CONCLUSIONS: In 69 % of @entity1 with endosonographically diagnosed gastric @entity5 , the @entity5 can also be visualized (and measured) using transabdominal ultrasound of the water-filled stomach. This noninvasive and inexpensive method may potentially be useful for surveillance in @entity1 with @entity5 , and further evaluation in this setting is warranted.

title: Transabdominal ultrasound for visualizing XXXX diagnosed by endosonography: can surveillance be simplified?

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['SMTs', 'tumor', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric submucosal tumors']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric submucosal tumors']


abstract: 1. The current-voltage relationships of @entity1347 of @entity840 have been determined using constant current and voltage clamp techniques. 2. The current-voltage relationships were non-linear over the membrane potential range -60 to -90 mV, the conductance increasing with hyperpolarization. 3. The membrane potential ranges over which the membrane conductance increased were changed by changing the external concentration of @entity972 ions. 4. Changing the external concentrations of @entity1372 and @entity2865 ions had no effect on the arteriolar current-voltage relationships. 5. The hyperpolarization-activated conductance increase was prevented by low concentrations of @entity9666 ions. 6. It is suggested that these arterioles display @entity972 -selective inward rectification and that the rectifier supplies the dominant resting @entity972 conductance. The properties of this rectifier are compared with those of other tissues.

title: Inward rectification in submucosal arterioles of XXXX ileum.

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['short segments of submucosal arteriole']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

answer: @entity840 :: (10141,Species) :: ['guinea-pig']


abstract: There were 2385 (1236 female, 1149 male) cases of @entity706 diagnosed in Kaunas region. Forty-five cases of histologically confirmed malignant @entity6595 diagnosed throughout 1981-2000 period are discussed. The disease was diagnosed to 37 @entity1 only after surgery and to other eight by means of endoscopical investigation. Before establishing the correct diagnosis, @entity356 was supposed to 27 @entity1 , gastric @entity1066 to 12 @entity1 , gastropathia erosiva to 6 @entity1 . Histologically primary non-Hodgkin @entity6595 was diagnosed to 29 @entity1 . That consisted 78.3 per cent of all surgically treated @entity1 , 64.4 per cent of histologically confirmed cases and 1.2 per cent of all diagnosed @entity706 . @entity356 was diagnosed to 16 @entity1 . Primary lymphogranulomatosis three cases. After supposed @entity5 , three @entity1 were operated. All @entity1 were examined by X-ray, CT and endoscopy. Biopsy was taken from pathological or not pathological mucous membrane.

title: [Diagnosis of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphomas', 'malignant lymphoma']

entities_list: @entity6595 :: ('MESH:C535648', 'Disease') :: ['gastric lymphoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stomach cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['Gastric lymphogranulomatosis', 'gastric carcinoma']

answer: @entity706 :: (MESH:D008223,Disease) :: ['malignant lymphoma of the stomach']


abstract: The objective of the study was to describe the practice patterns of the @entity1701 ( @entity1701 ) as compared with consensus guidelines for diagnosis and to determine whether practice patterns correlate with @entity1 demographics and physician specialty. A retrospective medical chart review was conducted at the American University Hospital, in Beirut, Lebanon. All adult and pediatric @entity1 admitted to the hospital between 1 January and 31 December 1998 who underwent either anticardiolipin antibodies (aCL) or @entity4555 ( @entity4555 ) testing were included in the study. @entity1701 was compared with: (a) the consensus guidelines for clinical diagnosis; (b) physician specialty; and (c) @entity1 demographics (age, gender, ethnicity, health insurance status). Eighty-seven @entity1 fulfilled at least one clinical criterion for @entity1701 ; 92% were for work-up of @entity715 and 8% for pregnancy morbidities. Fifty-one percent underwent both aCL and @entity4555 . Overall 38% (33) of @entity1 had an abnormal test result, however only 18% (6) underwent retesting, of whom only two satisfied a minimum of 6 weeks between test and retest TheAPS diagnostic work-up was requested by 11 different specialties. Rheumatologists were the most consistent in asking for both tests. @entity1701 is seen and diagnosed by a variety of medical specialties. Practice patterns as compared with the latest consensus are sub-optimal, and need to be improved. Interventions to help improve this have been discussed and are being implemented.

title: Practice patterns of XXXX at a tertiary teaching hospital in Lebanon.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity4555 :: ('MESH:C531622', 'Disease') :: ['lupus anticoagulant', 'LA']

entities_list: @entity1701 :: ('MESH:D016736', 'Disease') :: ['Work-up of APS syndrome', 'APS', 'antiphospholipid syndrome']

answer: @entity1701 :: (MESH:D016736,Disease) :: ['antiphospholipid syndrome']


abstract: Graves' @entity1378 and @entity2194 are closely related @entity792 . Whether the @entity2194 is an integral part of @entity2743 or a separate entity is controversial. To investigate this we have examined the genetic associations of @entity6875 and @entity1378 , and compared their phenotype and gene frequencies with a control normal population. @entity2149 , and DR antigens were typed in 67 @entity1 with @entity2194 ( @entity24481 ), 60 @entity1378 @entity1 without significant @entity2194 ( @entity101 ) and 500 normal subjects. @entity1 were also typed for a variety of other genetic markers: blood group systems (10), serum proteins (6) and red cell enzyme systems (10). Increased frequency of B8 and @entity4106 in @entity2743 was confirmed; @entity5147 occurred less frequently and appears to be protective. HLA antigen frequencies for @entity24481 did not differ from @entity101 . The MNS blood group showed a significant association with @entity2743 , the @entity101 @entity1 having a deficit of the s gene compared with controls. The most interesting finding was an increased frequency of blood group P in @entity24481 @entity1 compared with either @entity101 or controls. Significant differences were not seen with any of the other HLA antigens, blood groups, protein or enzyme markers considered individually. Multivariate analysis applied first to the HLA and then to the non-HLA systems indicated clear separation of the two @entity1 groups. Although @entity2194 shares the same HLA associations as @entity1378 , it differs in the increased frequency of P blood group, suggesting that additional genetic factors may determine which @entity1 with @entity2743 develop @entity6875 .

title: Differentiation of XXXX from Graves' @entity1378 by analysis of genetic markers.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ["Graves' eye disease", 'eye disease', 'dysthyroid eye disease']

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ["Graves' disease"]

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism', 'hyperthyroid']

entities_list: @entity6875 :: ('MESH:D049970', 'Disease') :: ['ophthalmopathy']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune conditions']

answer: @entity792 :: (MESH:D001327,Disease) :: ['autoimmune ophthalmopathy']


abstract: Graves' @entity1378 and @entity2194 are closely related @entity792 . Whether the @entity2194 is an integral part of @entity2743 or a separate entity is controversial. To investigate this we have examined the genetic associations of @entity6875 and @entity1378 , and compared their phenotype and gene frequencies with a control normal population. @entity2149 , and DR antigens were typed in 67 @entity1 with @entity2194 ( @entity24481 ), 60 @entity1378 @entity1 without significant @entity2194 ( @entity101 ) and 500 normal subjects. @entity1 were also typed for a variety of other genetic markers: blood group systems (10), serum proteins (6) and red cell enzyme systems (10). Increased frequency of B8 and @entity4106 in @entity2743 was confirmed; @entity5147 occurred less frequently and appears to be protective. HLA antigen frequencies for @entity24481 did not differ from @entity101 . The MNS blood group showed a significant association with @entity2743 , the @entity101 @entity1 having a deficit of the s gene compared with controls. The most interesting finding was an increased frequency of blood group P in @entity24481 @entity1 compared with either @entity101 or controls. Significant differences were not seen with any of the other HLA antigens, blood groups, protein or enzyme markers considered individually. Multivariate analysis applied first to the HLA and then to the non-HLA systems indicated clear separation of the two @entity1 groups. Although @entity2194 shares the same HLA associations as @entity1378 , it differs in the increased frequency of P blood group, suggesting that additional genetic factors may determine which @entity1 with @entity2743 develop @entity6875 .

title: Differentiation of @entity792 from Graves' XXXX by analysis of genetic markers.

answer: @entity1378 :: (MESH:D006980,Disease) :: ['hyperthyroidism']


abstract: @entity7334 of the calcaneus typically occur in individuals working on ladders, scaffolding or roofs. Male individuals in their productive age are most at risk. The functional problems that frequently persist are a well-known risk since they may obstruct a safe resumption of the former job. According to the data of the National Institute for Sickness and Invalidity Insurance the number of @entity174 in Belgium have stabilised over the last ten years. These figures indicate the necessity for a better prevention policy. Scientific literature about the problem of @entity717 in these cases is rare and lacks uniformity. A retrospective study was therefore performed on 65 private insurance compensation @entity1 who were treated for intra-articular @entity174 . The mean period of work incapacity was 260.5 days and the mean percentage of impairment was 12.3%. A large group (86.2%) were able to resume their former activities including the height workers. More than half of the @entity1 (57%) needed a supportive device. Working at heights and falls from a height were a significant risk factor for long-term work incapacity. The figures are compared with the limited literature and further discussed.

title: Impairment and return to work after XXXX of the calcaneus.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['calcaneal fractures']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['impairment and disability']

entities_list: @entity7334 :: ('MESH:D057072', 'Disease') :: ['Intra-articular fractures']

answer: @entity7334 :: (MESH:D057072,Disease) :: ['intra-articular fractures']


abstract: OBJECTIVES: We report our experience about @entity583 management in a small hospital with no possibility of coronarography. MATERIALS AND METHODS: In 1998, 60 @entity1 were hospitalized for @entity583 < 10 days. We studied characteristics of @entity1 , the management of @entity583 , the mortality. RESULTS: Our population consisted of 83% of @entity1 and 17% of @entity1 with a mean age of 63.5 and 74 years respectively. An out-hospital doctor was first warned by 60% of @entity1 . For hospitalization, the emergency ambulance service (SMUR) was used in 45% of cases, out-hospital doctors using these means of transport in 36% of cases. The global time of intervention was 18h30. The mean time for @entity1 managed in the first sixth hours was 2h10. A thrombolysis was applied for 35% of @entity1 (15% in prehospital that is to say 32% of "SMUR @entity1 ", and 20% in hospital). A transfer to the neighbouring university hospital for primary or rescue coronary angioplasty was decide for 41% of @entity1 . A total of 77% of our @entity1 underwent a coronarography. The global mortality at 10 days was 13.3% (< 75 years: 10.6%; > 75 years: 23%). CONCLUSIONS: A low volume centre and with no possibility of coronarography can manage the acute phase of @entity583 with results closed to those of the literature.

title: [Acute XXXX management in a hospital center with emergency ambulance service and intensive care unit, without cardiac catheterization laboratory].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'acute myocardial infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: PURPOSE: To determine if a mailed health promotion program reduced outpatient visits while improving health status. DESIGN: Randomized controlled trial. SETTING: A midsized, group practice model, managed care organization in Ohio. SUBJECTS: Members invited (N = 3214) were high utilizers, 18 to 64 years old, with @entity101 , @entity6 , or @entity625 (or all). A total of 886 members agreed to participate, and 593 members returned the initial questionnaires. The 593 members were randomized to the following groups: 99 into @entity625 treatment and 100 into @entity625 control, 94 into blood pressure treatment and 92 into blood pressure control, and 104 into @entity6 treatment and 104 into @entity6 control. MEASURES: Outpatient utilization, health status, and self-efficacy were followed over 30 months. INTERVENTIONS: Health risk appraisal questionnaires were mailed to treatment and control groups before randomization and at 1 year. The treatment group received three additional condition-specific ( @entity625 , @entity6 , or @entity101 ) questionnaires and a health information handbook. The treatment group also received written health education materials and an individualized feedback letter after each returned questionnaire. The control group received condition-specific written health education materials and reimbursement for exercise equipment or fitness club membership after returning the 1-year end of the study questionnaire. RESULTS: Changes in visit rates were disease specific. Parameter estimates were calculated from a Poisson regression model. For intervention vs. controls, the @entity625 group decreased visits 4.84 per 30 months (p < 0.00), the @entity6 group had no significant change, and the @entity101 group increased visits 2.89 per 30 months (p < 0.05), the overall health status improved significantly (-6.5 vs. 2.3, p < 0.01) for the @entity625 group but showed no significant change for the other two groups, and @entity453 and @entity5 risk scores did not change significantly for any group individually. Overall self-efficacy for intervention group completers improved by -8.6 points (p < 0.03) for the @entity625 group, and the other groups showed no significant change. CONCLUSIONS: This study demonstrated that in a population of 18 to 64 years with chronic conditions, mailed health promotion programs might only benefit @entity1 with certain conditions.

title: The impact of a health education program targeting XXXX with high visit rates in a managed care organization.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The availability of @entity2085 ( @entity2085 ) cells isolated from @entity1 blastocysts may open novel avenues for medical treatment of otherwise incurable diseases. Yet the generation of @entity1 @entity2085 cells requires the destruction of early @entity1 embryos. This confronts us with the moral problem of whether it is justifiable to sacrifice @entity1 life in order to treat other @entity1 life. This article outlines the development of the German debate about research with @entity2085 cells and explicates the arguments that are central to that debate with respect to the aims and means of research with @entity2085 cells. With regard to the means, the isolation of @entity2085 cells from @entity1 embryos raises the question of the moral status of the @entity1 embryo. A restrictive position acknowledges the @entity1 dignity of the embryo in its very early stage of development and claims that the embryo's life must be protected accordingly. In contrast, a gradualist position acknowledges @entity1 dignity, and therefore the full level of protection, only when the embryo has reached a certain stage of development. In addition, the intentions behind the generation of @entity1 embryos, i.e. exclusively for research purposes, and the mode of generating them, i.e. by nuclear transfer technology, have strong ethical relevance in the German debate. Based on these results, the ethical reasoning underlying the draft of a Stem Cell Act recently passed by the German Parliament is outlined.

title: Principles of ethical decision making regarding XXXX cell research in Germany.

entities_list: @entity2085 :: ('MESH:D020964', 'Disease') :: ['embryonic stem', 'ES']

answer: @entity2085 :: (MESH:D020964,Disease) :: ['embryonic stem']


abstract: According to the Rubicon Model of Action Phases (in: J. Gollwitzer, 1996), Motivation, volition, and action, Enzyclopedia of psychology, series "motivation and emotion", Vol. 4, Hogrefe, G  ttingen, 1996, pp. 531-582), different stages in goal pursuit are accompanied by different mindsets that enhance processing of mindset-congruous information. Before @entity1 engage in action, they usually deliberate possible goals for a given situation (deliberative mindset). Once a goal is chosen, they plan how to achieve this particular goal (implemental mindset). The present experiments tested the hypothesis that @entity1 with social @entity148 show a reversal of mindsets when approaching social situations. In Experiment 1, 20 students were asked to either deliberate goals for a hypothetical social conflict (deliberation), or to think about steps to solve the conflict (implementation). An unexpected recognition test demonstrated different recognition memory for deliberation-related versus implementation-related information in the two groups, consistent with the hypothesis of different mindsets. In Experiment 2, 48 students who were either high or low in social @entity148 were randomly assigned to either the deliberation or the implementation condition. @entity1 high in social @entity148 showed a pattern in the recognition test that was consistent with a reversal of mindsets. When asked to plan social situations, they showed an inappropriate deliberative mindset. In contrast, they lacked a deliberative mindset when deliberating goals for the social situation. The result indicate that socially anxious @entity1 engage in information processing that interferes with successful goal attainment when approaching social situations.

title: Mindsets in social XXXX : a new look at selective information processing.

entities_list: @entity1 :: ('9606', 'Species') :: ['people', 'Participants']

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: Obesity is a major chronic health problem in adults. It is a complex, @entity74 characterised by excess accumulation of adipose tissue. It is associated with a number of complications including @entity65 , @entity101 , @entity164 2 @entity6 , dyslipidaemia and @entity5 . A weight loss in the order of 5-10% is associated with clinically meaningful reductions with respect to all comorbidities. Diet and exercise has been the cornerstone of weight management therapy, but this approach has limitations, especially for weight maintenance. Previous drugs used in @entity28 had serious side effects including @entity340 . However, recent drugs like @entity350 and @entity352 have been rigorously tested and proven safe. @entity350 , a lipase inhibitor, inhibits absorption of dietary fat by approximately 30%. Taken with a hypocaloric diet, it produces and maintains clinically meaningful weight loss. @entity352 is a centrally-acting agent which enhances satiety and thermogenesis by inhibiting @entity750 and @entity1063 re-uptake. It is appropriate for @entity1 who are unable to lose weight by lifestyle modification.

title: Pharmacological management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity350 :: ('MESH:C055122', 'Chemical') :: ['Orlistat', 'orlistat']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity352 :: ('MESH:C058254', 'Chemical') :: ['Sibutramine', 'sibutramine']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['multifactorial disorder']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular heart disease']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['noradrenaline']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: The rate of recurrence of @entity354 after classic antireflux surgery (fundoplication) is 10-15%. This rate is different in @entity1 with @entity2910 with and without @entity355 . We evaluated the clinical and laboratory findings in 104 @entity1 with postoperative recurrent @entity354 , determining the results of repeat antireflux surgery or an acid suppression-bile diversion procedure. Repeat fundoplication was performed in 26 @entity1 , and truncal vagotomy, antrectomy, and Roux-en-Y gastrojejunostomy in 78 @entity1 . Esophagectomy as a third operation was performed in seven @entity1 . After repeat antireflux surgery, endoscopic evaluation demonstrated improvement of @entity2910 in a small proportion of @entity1 . @entity355 remained unchanged, and no regression of @entity1066 or stricture was observed. These complications improved significantly after acid suppression-bile diversion surgery. Incompetent lower esophageal sphincter (LES) was present in 55.8% after initial surgery and in 23% after reoperation. Acid reflux, initially present in 94.6% of @entity1 , was also observed in 93.6% after fundoplication, 68.8% after redo fundoplication, and 16.6% after treatment with the acid suppression-bile diversion technique. A positive Bilitec test was present in 78% of @entity1 before the operation and 56.6% after the repeat operation, and was negative after bile diversion surgery. Among 13 @entity1 (50%) submitted to repeat surgery alone, esophagectomy as a third operation was necessary as a result of severe non-dilatable stricture in seven @entity1 . Our conclusions are that repeat antireflux surgery alone failed to improve @entity355 and that the best results were obtained in @entity1 submitted to acid suppression-bile diversion surgery.

title: Results of surgical treatment for recurrent XXXX .

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus complications", "Barrett's esophagus"]

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['reflux esophagitis']

answer: @entity354 :: (MESH:D005764,Disease) :: ['postoperative gastroesophageal reflux']