abstract: BACKGROUND: We prospectively evaluated the effectiveness of major surgery in treating symptoms of advanced @entity5 . METHODS: Fifty-nine @entity1 were evaluated for major symptoms of intent to treat and were followed up until @entity204 or last clinical evaluation. Surgeons identified planned operations before surgery as either curative or palliative and estimated @entity1 survival time. An independent observer assessed symptom relief. A palliative surgery outcome score was determined for each symptomatic @entity1 . RESULTS: Surgeons identified 22 operations (37%) as palliative intent and 37 (63%) as curative intent. The median overall survival time was 14.9 months and did not differ between curative and palliative operations. Surgical morbidity was high but did not differ between palliative (41%) and curative (44%) operations. Thirty-three @entity1 (56%) were symptomatic before surgery, and major symptom resolution was achieved after surgery in 26 (79%) of 33. Good to excellent palliation, defined as a palliative surgery outcome score >70, was achieved in 64% of symptomatic @entity1 . CONCLUSIONS: Most symptomatic @entity1 with advanced @entity5 undergoing major operations attained good to excellent symptom relief. Outcome measurements other than survival are feasible and can better define the role of surgery in multimodality palliative care. A new outcome measure to evaluate major palliative operations is proposed.

title: A prospective evaluation of palliative outcomes for surgery of advanced XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignancies']


abstract: Twelve @entity1 with incompletely resected @entity1653 were treated with postoperative radiation therapy. Nine of these @entity1 had previously undergone incomplete surgical resection, and three had suffered one or more postoperative recurrences. The median dose of irradiation was 5490 rads in 6 weeks (range 4800 to 6080 rads). All @entity1 were followed with serial neurological examinations and computerized tomography (CT) scans. Median follow-up period was 54 1/2 months (range 20 to 120 months); 10 of the 12 @entity1 were followed for longer than 42 months posttreatment. Nine @entity1 had no clinical evidence of recurrent disease after radiation therapy, and CT scans confirmed lack of progression or a gradual decrease in @entity5 size. Three @entity1 had @entity5 recurrences; two of these lesions appeared at 70 and 112 months after irradiation as extracranial extensions beyond the margin of the irradiation field, and one has exhibited recurrence within the field at 48 months. Three @entity1 who were treated after prior recurrences have demonstrated prolonged progression-free intervals in comparison to the intervals between recurrences prior to irradiation. No significant complications attributable to treatment have been found in any of the @entity1 . These results are discussed in relation to previous reports of the incidence of @entity1653 after incomplete resection.

title: Radiation therapy for incompletely resected XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['meningioma recurrence', 'meningiomas']

answer: @entity1653 :: (MESH:D008579,Disease) :: ['meningiomas']


abstract: @entity10220 of the fourth ventricle are generally considered incidental postmortem findings, and have received scant attention from neurosurgeons. The authors present a surgical series of 12 cases of this disorder diagnosed over a 13-year period. The clinical and radiological findings were reviewed and correlations made with pathological studies. The @entity10220 is a histologically benign @entity5 that tends to be calcified. It has a predilection for the fourth ventricle and a peak incidence in the fifth decade of life. It is usually of considerable size with extensive attachment at the time of its detection, and is associated with significant surgical morbidity. The authors believe that magnetic resonance imaging may be the best method of investigation. Intraoperative disturbance of circulatory or respiratory control should suggest to the surgeon that the operation be abandoned. A laser or ultrasonic aspirator may be very helpful in removing these @entity5 . Postoperative care must include monitoring for @entity386 .

title: XXXX of the fourth ventricle. Surgical treatment in 12 cases.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity10220 :: ('MESH:D018315', 'Disease') :: ['Subependymomas', 'subependymoma']

answer: @entity10220 :: (MESH:D018315,Disease) :: ['Subependymomas']


abstract: BACKGROUND: The use of high-dose adjuvant chemotherapy for high-risk primary @entity0 is controversial. We studied its efficacy in @entity1 with 4 to 9 or 10 or more @entity5 -positive axillary lymph nodes. METHODS: @entity1 younger than 56 years of age who had undergone surgery for @entity0 and who had no distant metastases were eligible if they had at least four @entity5 -positive axillary lymph nodes. @entity1 in the conventional-dose group received @entity1487 , @entity1259 , and @entity786 (FEC) every three weeks for five courses, followed by radiotherapy and @entity440 . The high-dose treatment was identical, except that high-dose chemotherapy (6 g of @entity786 per square meter of body-surface area, 480 mg of thiotepa per square meter, and 1600 mg of @entity3003 per square meter) with autologous peripheral-blood hematopoietic progenitor-cell transplantation replaced the fifth course of FEC. RESULTS: Of the 885 @entity1 , 442 were assigned to the high-dose group and 443 to the conventional-dose group. After a median follow-up of 57 months, the actuarial 5-year relapse-free survival rates were 59 percent in the conventional-dose group and 65 percent in the high-dose group (hazard ratio for relapse in the high-dose group, 0.83; 95 percent confidence interval, 0.66 to 1.03; P=0.09). In the group with 10 or more positive nodes, the relapse-free survival rates were 51 percent in the conventional-dose group and 61 percent in the high-dose group (P=0.05 by the log-rank test; hazard ratio for relapse, 0.71; 95 percent confidence interval, 0.50 to 1.00). CONCLUSIONS: High-dose alkylating therapy improves relapse-free survival among @entity1 with @entity0 and 10 or more positive axillary lymph nodes. This benefit may be confined to @entity1 with @entity5 .

title: High-dose chemotherapy with hematopoietic stem-cell rescue for high-risk XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'stage II or III breast cancer']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'HER-2/neu-negative tumors']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: Percutaneous closure of @entity118 ( @entity118 ) is increasingly performed in pediatric and adult @entity1 . This study reports a single-center experience with the use of the Amplatzer Septal Occluder for percutaneous @entity118 closure in adults. One hundred and seventeen consecutive @entity1 were prospectively included in the database. The procedure was successful in 106 @entity1 (90.6%). The mean age was 50 years. Eighty-four percent of the @entity1 had a Qp:Qs > 1.5. Other indications included a history of @entity1031 , decreased exercise tolerance, @entity943 , evidence of @entity120 or right heart overload. Mean procedure time was 44 minutes, and mean fluoroscopy time was 13 minutes. The mean defect diameter was 17.2 mm (range, 5 30 mm). There was no residual shunting at the end of the procedure in 75% of the @entity1 . Shunting was minimal in all but 2 of the remaining 25 @entity1 (1.8%). No major complications were observed at a mean follow-up of 19 months. @entity1 in whom the procedure failed had larger defects (mean, 25.0 mm versus 18.3 mm; p < 0.001), larger right ventricles (44.1 mm versus 38.2 mm; p = 0.03) and more significant shunting (Qp:Qs, 3.5 versus 2.1; p < 0.001). New York Heart Association functional class improved in all but 1 @entity1 . Percutaneous @entity118 closure using ASO is safe and mid-term results compare favorably with those reported with surgical @entity118 closure. It can therefore be recommended as the first line of treatment in adult @entity1 with secundum @entity118 .

title: Percutaneous closure of secundum XXXX in adults a single center experience with the amplatzer septal occluder.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']

entities_list: @entity118 :: ('MESH:D006344', 'Disease') :: ['atrial septal defects', 'ASD']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['atrial arrhythmias']

answer: @entity118 :: (MESH:D006344,Disease) :: ['atrial septal defect']


abstract: BACKGROUND: @entity1455 ( @entity1455 ) in @entity583 ( @entity583 ) is associated with high rates of mortality. Smaller ventricular assist devices, such as the intraaortic balloon pump, provide limited support. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) offers more robust mechanical ventricular support, but is not widely utilized by interventional cardiologists. This study aimed to evaluate the @entity1 characteristics and outcomes of VA-ECMO with @entity1455 in the setting of @entity583 . METHODS AND RESULTS: A retrospective chart review of all VA-ECMO cannulations between 2009 and 2014 was performed, and @entity1 with an indication of @entity1455 in @entity583 were identified. A total of 15 @entity1 underwent VA-ECMO placement for @entity583 with @entity1455 . One-third of these @entity1 presented with out-of-hospital @entity1167 , and 60% had ST-elevation @entity583 . The Intraaortic balloon pump was placed in addition to VA-ECMO in 60% of @entity1 . Median duration of VA-ECMO support was 45 hours. Successful wean off VA-ECMO was obtained in 50% of the @entity1 , and @entity455 occurred in 53% of @entity1 . The survival rate at discharge was 47%, and all survivors were alive at 30 days post discharge. CONCLUSION: VA-ECMO is infrequently used in @entity1 for cardiopulmonary resuscitation in the @entity583 setting. When used judiciously, it has good clinical outcomes in this group of @entity1 . However, use of VA-ECMO should be individualized based on vascular anatomy for best results. Close cooperation among interventional cardiologists, cardiovascular surgeons, cardiologists, cardiac intensivists, and perfusionists is essential for success of this therapy for @entity1455 in @entity583 .

title: Contemporary Use of Veno-Arterial Extracorporeal Membrane Oxygenation for Refractory XXXX in Acute Coronary Syndrome.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular complications']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'myocardial infarction', 'acute myocardial infarction']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['RCS', 'Refractory cardiogenic shock']

answer: @entity1455 :: (MESH:D012770,Disease) :: ['Cardiogenic Shock']


abstract: BACKGROUND: Conflicting interpretations about the structure and function of the body contribute to discordance in communication between healthcare professionals and lay @entity1 . Understanding musculoskeletal (MSK) complaints presents additional complexities when discussed in more than one language or in cross-cultural settings. In low- and middle-income countries (LMICs), few healthcare professionals have specialist MSK training and not all practitioners speak the primary language of @entity1 . OBJECTIVE: Our goal was to understand how @entity1 in rural Botswana perceive and express MSK complaints. DESIGN: Ethnographic fieldwork for 8 months in the Botswana Central District included @entity1 observations and interviews with 34 community members with MSK complaints. Audio-recorded interviews were typically conducted in Setswana with an interpreter, transcribed verbatim, and contextually translated into English. Abductive qualitative analysis was used as the interpretive methodology. RESULTS: Whereas initial responses about MSK troubles yielded the exclamation botlhoko, botlhoko! combined with animated @entity1742 and facial expressions indicating @entity158 , in-depth interviews revealed the complexities of @entity158 expression among respondents. MSK @entity158 were described as 'bursting, exploding, aching, @entity1183 , hot, pricking, stabbing, swollen, and @entity158 in the heart'. Language subtleties manifested during interviews, where 'meat' or 'flesh' implied soft tissue @entity158 ; waist @entity158 were voiced yet portrayed as low back or @entity158 ; and 'veins' variously referred to structural and functional types of @entity158 . Psychological and social stressors accompanied many accounts of MSK troubles. CONCLUSIONS: Respondents offered diverse MSK symptom descriptions consistent with @entity221 models, yet few communicated complaints using the biomedical language of healthcare providers. Although research interview and transcription processes may not be practical for clinicians, working with interpreters who communicate detailed @entity1 accounts for MSK troubles will complement @entity1 -provider encounters. Community member perceptions of their MSK @entity158 and associated conditions should be explored and incorporated into healthcare interventions and innovations for rural communities in LMICs.

title: Botlhoko, botlhoko! How XXXX talk about their musculoskeletal complaints in rural Botswana: a focused ethnography.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'participant', 'people', 'patient']

entities_list: @entity1742 :: ('MESH:D001072', 'Disease') :: ['non-verbal gestures']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pains', 'widespread body pains', 'pain', 'sacroiliac pain']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['biopsychosocial illness']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: To understand @entity876 gene change of @entity1893 ( @entity1893 ) and @entity1 @entity706 cell lines, the exons 5-7 of 29 @entity1 with @entity1893 and 9 kinds of @entity1 @entity706 cell lines were studied by @entity575 staining PCR-SSCP technique. Three cases of @entity876 gene point mutation was found in 29 cases of @entity1893 . Mutation developed in exon 5 in 2 cases, and in exon 6 in 1 case. They were all @entity706 . In mutation cases, @entity1892 accounted for 2 cases and the other one was @entity784 . There was no @entity876 gene mutation in low-grade @entity706 . Seven strains out of 9 kinds of @entity706 cell lines had @entity876 gene point mutation. One strain had the mutation in exon 5; 5 strains in exon 6 and 1 strain in exons 5, 6, 7. There was a high mutation rate in @entity706 cell lines and low mutation rate in @entity1893 @entity1 . @entity876 gene plays an important role in @entity706 cell line establishment, cell regeneration and disease evolution.

title: XXXX gene mutations in @entity1893 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'diffuse lymphoma', 'malignant lymphoma', 'follicular lymphoma']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphoma']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL']

answer: @entity876 :: (7157,Gene) :: ['P53']


abstract: To understand @entity876 gene change of @entity1893 ( @entity1893 ) and @entity1 @entity706 cell lines, the exons 5-7 of 29 @entity1 with @entity1893 and 9 kinds of @entity1 @entity706 cell lines were studied by @entity575 staining PCR-SSCP technique. Three cases of @entity876 gene point mutation was found in 29 cases of @entity1893 . Mutation developed in exon 5 in 2 cases, and in exon 6 in 1 case. They were all @entity706 . In mutation cases, @entity1892 accounted for 2 cases and the other one was @entity784 . There was no @entity876 gene mutation in low-grade @entity706 . Seven strains out of 9 kinds of @entity706 cell lines had @entity876 gene point mutation. One strain had the mutation in exon 5; 5 strains in exon 6 and 1 strain in exons 5, 6, 7. There was a high mutation rate in @entity706 cell lines and low mutation rate in @entity1893 @entity1 . @entity876 gene plays an important role in @entity706 cell line establishment, cell regeneration and disease evolution.

title: @entity876 gene mutations in XXXX .

answer: @entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin's lymphoma']


abstract: UNASSIGNED: Overeating (eating an unusually large amount of food) and @entity6426 ( @entity7298 with loss of control [LOC]) predict adverse health consequences in adolescence. We aimed to characterize the stability of and risk factors for these distinct but interrelated constructs during critical developmental transitions. We used a population-based sample (n = 1,902) that completed surveys at 5-year intervals spanning adolescence and young adulthood. The trajectories of no @entity7298 , @entity7298 , @entity6426 , and @entity5550 ( @entity5550 ; recurrent @entity6426 with associated distress) were characterized using cross-tabulations. Body mass index, @entity308 , self-esteem, and body satisfaction were examined as risk factors for no @entity7298 , @entity7298 , and @entity6426 (including @entity5550 ) 5-years later using multinomial logistic regression. We found that all @entity7298 categories tended to remit to no @entity7298 at 5-year follow-up. Although @entity7298 had the lowest remittance rates at each time-point, @entity6426 and @entity5550 showed higher rates of persistence or worsening of symptoms during the transition from late adolescence/early young adulthood to early/middle young adulthood. Overeating and @entity6426 had similar risk factors, although for females, @entity308 , body satisfaction, and self-esteem in late adolescence/early young adulthood differentially predicted @entity6426 in early/middle young adulthood (ps < .05). While @entity7298 with or without LOC tends to remit over time, problematic eating persists for a subset of individuals. Greater psychosocial problems in late adolescence/early young adulthood predicted greater odds of @entity6426 relative to @entity7298 in early/middle young adulthood among females, indicating that poorer psychosocial functioning in this developmental stage portends more severe eating-related psychopathology later in life. (PsycINFO Database Record

title: Overeating and XXXX in emerging adulthood: 10-year stability and risk factors.

entities_list: @entity7298 :: ('MESH:D006963', 'Disease') :: ['overeating']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms']

entities_list: @entity5550 :: ('MESH:D056912', 'Disease') :: ['BED', 'binge eating disorder']

entities_list: @entity6426 :: ('MESH:D002032', 'Disease') :: ['binge eating versus overeating', 'binge eating']

answer: @entity6426 :: (MESH:D002032,Disease) :: ['binge eating']


abstract: Some researchers have reported that lactation is effective in reducing @entity65 risk factors. The purpose of this study was to investigate whether lactation may improve intrinsic tolerance against @entity63 reperfusion (IR) injury. The @entity35 were randomly divided into two groups (n = 8 in each group). In the lactation (Lact) group, the surgery was performed on postpartum day 21 (at the end of lactation period) and the results were compared with those of virgin female @entity35 (control group). @entity5721 was induced by means of left anterior descending @entity1563 for 30 min followed by reperfusion for 120 min. @entity1188 size was measured using the staining agent @entity5045 . At the end of the experiment, Mean arterial pressure in the control group was significantly lower than that in the Lact group. @entity583 size was significantly reduced in the Lact group (23    3% vs. 45    8%, p < 0.05 in the control group). Lactation reduced the extent of @entity296 induced by @entity63 and reperfusion. So, lactation may increase cardiac tolerance to @entity63 .

title: Lactation protects against myocardial ischemia-reperfusion injury in XXXX .

entities_list: @entity5045 :: ('MESH:C009591', 'Chemical') :: ['2,3,5-triphenyltetrazolium chloride']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial injury']

entities_list: @entity5721 :: ('MESH:D015427', 'Disease') :: ['Cardiac IR injury']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury', 'ischemia']

entities_list: @entity1563 :: ('MESH:D054059', 'Disease') :: ['coronary artery occlusion']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['Myocardial infarct']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: The most common use of inotropes is among hospitalized @entity1 with acute decompensated @entity712 , with reduced left ventricular ejection fraction and with signs of @entity881 in the setting of a @entity998 . Inotropes can be used in @entity1 with severe systolic @entity712 awaiting heart transplant to maintain hemodynamic stability or as a bridge to decision. In cases where @entity1 are unable to be weaned off inotropes, these agents can be used until a definite or escalated supportive therapy is planned, which can include coronary revascularization or mechanical circulatory support (intra-aortic balloon pump, extracorporeal membrane oxygenation, impella, left ventricular assist device, etc.). Use of inotropic drugs is associated with risks and adverse events. This review will discuss the use of the inotropes @entity6838 , @entity935 , @entity452 , @entity1063 , @entity7604 , @entity6759 , and omecamtiv mecarbil. Long-term inotropic therapy should be offered in selected @entity1 . A detailed conversation with the @entity1 and family shall be held, including a discussion on the risks and benefits of use of inotropes. @entity712 @entity1 awaiting heart transplants are candidates for intravenous inotropic support until the donor heart becomes available. This helps to maintain hemodynamic stability and keep the fluid status and pulmonary pressures optimized prior to the surgery. On the other hand, in @entity1 with severe @entity712 who are not candidates for advanced @entity712 therapies, such as transplant and mechanical circulatory support, inotropic agents can be used for palliative therapy. Inotropes can help reduce frequency of hospitalizations and improve symptoms in these @entity1 .

title: Use of Inotropic Agents in Treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Chronic heart failure', 'heart failure']

entities_list: @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine']

entities_list: @entity998 :: ('MESH:D002303', 'Disease') :: ['low cardiac output']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity6759 :: ('MESH:C076731', 'Chemical') :: ['levosimendan']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['end-organ dysfunction']

entities_list: @entity7604 :: ('MESH:D020105', 'Chemical') :: ['milrinone']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

answer: @entity712 :: (MESH:D006333,Disease) :: ['Systolic Heart Failure']


abstract: BACKGROUND: @entity3013 ( @entity3013 ) is a core component of cardiac rehabilitation. We investigated the effects of @entity3013 on exercise capacity, muscle strength, and mobility in middle-aged and elderly @entity1 with @entity453 ( @entity453 ). METHODS: We searched for randomized controlled trials of @entity3013 versus usual care, or combined @entity3013 and @entity411 ( @entity411 ) versus @entity411 alone, and identified 440 trials in total from inception to January 2014. @entity1 who had @entity583 , coronary revascularization, @entity951 or @entity453 were included in the analysis. Those who had @entity712 , heart transplants with either cardiac resynchronization therapy or implantable defibrillators were excluded. RESULTS: Twenty-two trials totaling 1095 @entity1 were analyzed. We performed random-effects meta-analysis. In middle-aged @entity1 , @entity3013 increased lower extremity muscle strength [standardized mean difference (SMD): 0.65, 95% confidence interval (CI): 0.35 to 0.95], upper extremity muscle strength (SMD: 0.73, 95% CI: 0.48 to 0.99) and peak @entity26 consumption (VO2) [weight mean difference (WMD): 0.92mL/kg/min, 95% CI: 0.12 to 1.72], but did not improve mobility compared with the control. In elderly @entity1 , @entity3013 increased lower extremity muscle strength (SMD: 0.63, 95% CI: 0.05 to 1.21), upper extremity muscle strength (SMD: 1.18, 95% CI: 0.56 to 1.80), and peak VO2 (WMD: 0.70mL/kg/min, 95% CI: 0.03 to 1.37), and improved mobility (SMD: 0.61, 95% CI: 0.21 to 1.01) compared with the control. CONCLUSIONS: @entity3013 could increase exercise capacity and muscle strength in middle-aged and elderly @entity1 , and mobility in elderly @entity1 , with @entity453 .

title: Effects of resistance training on muscle strength, exercise capacity, and mobility in middle-aged and elderly @entity1 with XXXX : A meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity3013 :: ('MESH:D060467', 'Disease') :: ['RT', 'Resistance training']

entities_list: @entity951 :: ('MESH:D000787', 'Disease') :: ['angina pectoris']

entities_list: @entity411 :: ('MESH:C538054', 'Disease') :: ['aerobic training', 'AT']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: BACKGROUND: @entity3013 ( @entity3013 ) is a core component of cardiac rehabilitation. We investigated the effects of @entity3013 on exercise capacity, muscle strength, and mobility in middle-aged and elderly @entity1 with @entity453 ( @entity453 ). METHODS: We searched for randomized controlled trials of @entity3013 versus usual care, or combined @entity3013 and @entity411 ( @entity411 ) versus @entity411 alone, and identified 440 trials in total from inception to January 2014. @entity1 who had @entity583 , coronary revascularization, @entity951 or @entity453 were included in the analysis. Those who had @entity712 , heart transplants with either cardiac resynchronization therapy or implantable defibrillators were excluded. RESULTS: Twenty-two trials totaling 1095 @entity1 were analyzed. We performed random-effects meta-analysis. In middle-aged @entity1 , @entity3013 increased lower extremity muscle strength [standardized mean difference (SMD): 0.65, 95% confidence interval (CI): 0.35 to 0.95], upper extremity muscle strength (SMD: 0.73, 95% CI: 0.48 to 0.99) and peak @entity26 consumption (VO2) [weight mean difference (WMD): 0.92mL/kg/min, 95% CI: 0.12 to 1.72], but did not improve mobility compared with the control. In elderly @entity1 , @entity3013 increased lower extremity muscle strength (SMD: 0.63, 95% CI: 0.05 to 1.21), upper extremity muscle strength (SMD: 1.18, 95% CI: 0.56 to 1.80), and peak VO2 (WMD: 0.70mL/kg/min, 95% CI: 0.03 to 1.37), and improved mobility (SMD: 0.61, 95% CI: 0.21 to 1.01) compared with the control. CONCLUSIONS: @entity3013 could increase exercise capacity and muscle strength in middle-aged and elderly @entity1 , and mobility in elderly @entity1 , with @entity453 .

title: Effects of resistance training on muscle strength, exercise capacity, and mobility in middle-aged and elderly XXXX with @entity453 : A meta-analysis.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Optimizing quality of life is a major goal for @entity1 with unresectable @entity788 . The aim of this study was to assess the value of robotic surgery for palliation in these @entity1 . METHODS: Between May 2007 and January 2010, nine @entity1 who presented with unresectable pancreatic @entity5 or @entity201 at exploratory laparoscopy were included in this retrospective study. RESULTS: Eight hepaticojejunostomies, one choledochoduodenostomy and five gastrojejunostomies were performed robotically. Mean operative time was 236    25 min. Median length of stay was 6 (range 4-10) days. There was no perioperative mortality. The morbidity rate was 22.2%. After a median follow-up of 265 days, there were no other readmissions for problems related to the operation. CONCLUSIONS: Robotic palliation in cases of unresectable pancreatic @entity5 or @entity201 is feasible and effective. The use of robotics in palliative surgery offers low morbidity, short hospital stay and minimal readmissions.

title: Robotic palliation for unresectable XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer and distal cholangiocarcinoma']

entities_list: @entity201 :: ('MESH:D018281', 'Disease') :: ['distal cholangiocarcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer and distal cholangiocarcinoma']


abstract: OBJECTIVE: Several studies have shown structural and statistical similarities between the Diagnostic and Statistical Manual of @entity146 , 5(th) edition ( @entity4987 ) alternative @entity1314 model and the @entity4059 ( @entity4059 ). However, no study to date has evaluated the nomological network similarities between the two models. METHOD: The relations of the Revised NEO Personality Inventory (NEO PI-R) and the Personality Inventory for @entity4987 (PID-5) with relevant criterion variables were examined in a sample of 336 undergraduate students (age M = 19.4, 59.8% female). The resulting profiles for each instrument were statistically compared for similarity. RESULTS: Four of the five domains of the two models have highly similar nomological networks, with the exception being @entity4059 @entity1538 to Experience and PID-5 Psychoticism. Further probing of that pair suggested that the NEO PI-R domain scores obscured meaningful similarity between PID-5 Psychoticism and specific aspects and lower-order facets of @entity1538 . CONCLUSIONS: The results support the notion that the @entity4987 alternative PD model trait domains represent variants of the @entity4059 domains. Similarities of @entity1538 and Psychoticism domains were supported when the lower-order aspects and facets of @entity1538 domain were considered. The findings support the view that the @entity4987 trait model represents an instantiation of the @entity4059 . This article is protected by copyright. All rights reserved.

title: Capturing the XXXX Alternative Personality Disorder Model Traits in the Five-Factor Model's Nomological Net.

entities_list: @entity4059 :: ('MESH:D007020', 'Disease') :: ['FFM', 'five-factor model']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental Disorders']

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['personality disorder']

answer: @entity4987 :: (1398,Species) :: ['DSM-5']


abstract: @entity779 , @entity1800 , causes significant morbidity and has become endemic in the Indian subcontinent. Virus strains currently circulating in many parts of the country are not well studied at the molecular level. In the present study, genetic characterization of virus strains from a dengue outbreak that occurred in and around a tertiary care hospital in Ernakulam, Kerala in the year 2008 has been reported. By reverse transcription polymerase chain reaction (RT-PCR), 37 out of 75 (49.3%) clinically suspected cases were positive for dengue viral RNA. Among these, 21 (56.8%) samples showed concurrent @entity281 with multiple serotypes of the virus. Majority of the combined infections were caused by @entity779 and 3. @entity325 with type 1 and 2 in two @entity1 , and type 1, 2 and 3 in one @entity1 were also observed. The core-pre-Membrane (CprM) junction @entity377 sequencing and phylogenetic analysis revealed that the type 1 strains were related to the viral strains reported from Delhi-2001 and Gwalior-2002 dengue outbreaks, while the type 2 strains were related to the strains from Gwalior-2001 epidemic. Sequences of type 3 strains did not show clear relation to any of the previous Indian isolates, and in the phylogenetic analysis, they formed a distinct lineage within the Indian type 3 strains. This study indicates @entity779 in the region with the presence of multiple serotypes and high rates of @entity325 , and local genomic evolution of the viral strains involved in this outbreak.

title: Genetic characterization of dengue virus serotypes causing concurrent XXXX in an outbreak in Ernakulam, Kerala, South India.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['a mosquito-borne viral infection']

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['Co-infections', 'co-infection']

entities_list: @entity779 :: ('MESH:D003715', 'Disease') :: ['dengue serotype 2', 'Dengue fever', 'hyperendemicity of dengue']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infection']


abstract: OBJECTIVE: To determine risk factors for a @entity1162 and evaluate the maternal and neonatal outcomes of such pregnancies. METHODS: We reviewed all 7818 @entity1 who delivered at the University of Illinois at Chicago from 1996 to 1999. Excluding nonvertex and multiple gestations, 6791 reached the second stage. Group 1 (n = 6259) consisted of @entity1 with a second stage of 120 minutes or less; group 2, greater than 120 minutes (n = 532 [7.8%]); group 2A, 121-240 minutes (n = 384 [5.7%]); and group 2B, greater than 240 minutes (n = 148 [2.2%]). We compared pregnancy outcomes for these groups with respect to maternal and neonatal morbidity factors using chi(2), Student t, and Wilcoxon rank-sum tests (significance, P <.05). RESULTS: Vaginal delivery rates were 98.7% (group 1), 84.0% (group 2), 90.2% (group 2A), and 65.5% (group 2B). Group 2 had higher rates of perineal @entity130 , episiotomy usage, @entity5870 , postpartum @entity548 , and operative vaginal delivery than group 1 (P <.001, all comparisons). Group 2B had higher rates of episiotomy usage, operative vaginal deliveries, and perineal @entity130 than group 2A (P <.001, all comparisons). The neonatal morbidity rates were similar for the three groups. @entity6 , @entity1468 (P <.023), @entity8455 , nulliparity, @entity5870 , @entity398 usage, and labor induction were each independently associated with an increased risk of a prolonged second stage (all but @entity1468 , P <.001). CONCLUSION: A prolonged second stage is associated with a high rate of vaginal delivery, but a high rate of maternal, though not neonatal, morbidity was observed. Certain antenatal and intrapartum conditions are associated with a @entity1162 .

title: Maternal and neonatal outcomes in @entity1 with a XXXX .

entities_list: @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes']

entities_list: @entity5870 :: ('MESH:D002821', 'Disease') :: ['chorioamnionitis']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']

entities_list: @entity8455 :: ('MESH:D005320', 'Disease') :: ['macrosomia']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['prolonged second stage of labor']

answer: @entity1162 :: (MESH:D008133,Disease) :: ['prolonged second stage of labor']


abstract: OBJECTIVE: To determine risk factors for a @entity1162 and evaluate the maternal and neonatal outcomes of such pregnancies. METHODS: We reviewed all 7818 @entity1 who delivered at the University of Illinois at Chicago from 1996 to 1999. Excluding nonvertex and multiple gestations, 6791 reached the second stage. Group 1 (n = 6259) consisted of @entity1 with a second stage of 120 minutes or less; group 2, greater than 120 minutes (n = 532 [7.8%]); group 2A, 121-240 minutes (n = 384 [5.7%]); and group 2B, greater than 240 minutes (n = 148 [2.2%]). We compared pregnancy outcomes for these groups with respect to maternal and neonatal morbidity factors using chi(2), Student t, and Wilcoxon rank-sum tests (significance, P <.05). RESULTS: Vaginal delivery rates were 98.7% (group 1), 84.0% (group 2), 90.2% (group 2A), and 65.5% (group 2B). Group 2 had higher rates of perineal @entity130 , episiotomy usage, @entity5870 , postpartum @entity548 , and operative vaginal delivery than group 1 (P <.001, all comparisons). Group 2B had higher rates of episiotomy usage, operative vaginal deliveries, and perineal @entity130 than group 2A (P <.001, all comparisons). The neonatal morbidity rates were similar for the three groups. @entity6 , @entity1468 (P <.023), @entity8455 , nulliparity, @entity5870 , @entity398 usage, and labor induction were each independently associated with an increased risk of a prolonged second stage (all but @entity1468 , P <.001). CONCLUSION: A prolonged second stage is associated with a high rate of vaginal delivery, but a high rate of maternal, though not neonatal, morbidity was observed. Certain antenatal and intrapartum conditions are associated with a @entity1162 .

title: Maternal and neonatal outcomes in XXXX with a @entity1162 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The majority of @entity5 @entity1 wish to die at home. Improved understanding of place of @entity204 and its relevant demographic predictors is important for the planning of @entity5 care programs. The purpose of this study was to determine the place and predictors of site of @entity204 in @entity5 @entity1 in a major U.S. metropolitan area. Death certificate data over two years were analyzed for Houston area residents with @entity5 who died in the Houston area. Information was obtained on factors that might be associated with the place where @entity5 @entity1 die. For the purpose of this study, we looked at the following variables: primary site of @entity5 (hematological, breast, genitourinary, gastrointestinal, lung, and other); black, white, Hispanic, or Asian; age at @entity204 ; marital status; sex; whether or not veteran of U.S. armed forces; levels of education; and area of residency within the Houston area. Univariate and multivariate analyses were performed. The majority of @entity1 died in the hospital (51-52% both years), with the next most frequently occurring group dying at home (34-35% both years). Stepwise multivariate analysis resulted in a 6-variable logistic regression model. In this model, the odds of dying in hospital were increased by a factor of 2.7 if the @entity1 had a hematological @entity5 (P<0.0001), a factor of 1.6 if the @entity1 lived in Harris County (P<0.0001), and a factor of 1.5 if the @entity1 was black (P<0.0001). Further characterization of factors associated with increased risk of hospital @entity204 rate is needed and systems should be developed to enable the majority of @entity5 @entity1 to access palliative care services in the multiple settings in which they die.

title: Place of XXXX of Houston area residents with @entity5 over a two-year period.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'palliative cancer']

answer: @entity204 :: (MESH:D003643,Disease) :: ['death']


abstract: The majority of @entity5 @entity1 wish to die at home. Improved understanding of place of @entity204 and its relevant demographic predictors is important for the planning of @entity5 care programs. The purpose of this study was to determine the place and predictors of site of @entity204 in @entity5 @entity1 in a major U.S. metropolitan area. Death certificate data over two years were analyzed for Houston area residents with @entity5 who died in the Houston area. Information was obtained on factors that might be associated with the place where @entity5 @entity1 die. For the purpose of this study, we looked at the following variables: primary site of @entity5 (hematological, breast, genitourinary, gastrointestinal, lung, and other); black, white, Hispanic, or Asian; age at @entity204 ; marital status; sex; whether or not veteran of U.S. armed forces; levels of education; and area of residency within the Houston area. Univariate and multivariate analyses were performed. The majority of @entity1 died in the hospital (51-52% both years), with the next most frequently occurring group dying at home (34-35% both years). Stepwise multivariate analysis resulted in a 6-variable logistic regression model. In this model, the odds of dying in hospital were increased by a factor of 2.7 if the @entity1 had a hematological @entity5 (P<0.0001), a factor of 1.6 if the @entity1 lived in Harris County (P<0.0001), and a factor of 1.5 if the @entity1 was black (P<0.0001). Further characterization of factors associated with increased risk of hospital @entity204 rate is needed and systems should be developed to enable the majority of @entity5 @entity1 to access palliative care services in the multiple settings in which they die.

title: Place of @entity204 of Houston area residents with XXXX over a two-year period.

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: OBJECTIVE: To describe the experience with @entity360 in two major Latin American hospitals; presenting its main causes, treatment, and prognosis, while exploring some risk factors associated with @entity204 . DESIGN: Prospective cohort study. @entity1 AND METHODS: Four hundred and sixty four @entity1 were admitted into any of the 2 hospitals and were at least 15 years of age. Some variables demographics, clinics and treatment were studied. The association between those variables and the @entity204 were explored. RESULTS: Mean age was 57.9 years; the @entity1 : @entity1 ratio was 1.4:1. Three hundred and fifty nine @entity1 (77.3%) presented as outpatients and 105 @entity1 (22.6%) were inpatients presenting with UGIB. 71.6% of @entity1 had an upper GI endoscopy within 24 hours. The main causes of @entity548 were peptic ulcer (190 @entity1 , 41%), @entity66 (162 @entity1 , 34.9%) and variceal @entity548 (47 @entity1 , 10.1%). Forty four @entity1 died (9.5%). Bleeding as an inpatient has a higher mortality risk than does @entity548 as an outpatient (RR 2.4 IC 95% 1.2-4.6). An increasing number of comorbidities such as those described in the Rockall Score are also associated with a higher risk of dying (RR 2.5 IC 95% 1.1-5.4). CONCLUSION: UGIB as an inpatient and the presence of comorbidities should alert the clinician in identifying @entity1 at higher risk of a fatal outcome, these @entity1 should have a more aggressive management and be entitled to an early intervention.

title: Upper XXXX : risk factors for mortality in two urban centres in Latin America.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'men']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['erosive disease']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['upper gastrointestinal bleeding']

answer: @entity360 :: (MESH:D006471,Disease) :: ['gastrointestinal bleeding']


abstract: OBJECTIVE: To study the prevalence of @entity148 and @entity308 in @entity1 with @entity565 and to identify associated factors. MATERIAL AND METHODS: The study was based on individual data of subjects aged >= 18 years drawn from the 2006 Spanish National Health Survey. We identified @entity748 individuals through a specific questionnaire. Presence of @entity308 or @entity148 was assessed using the following questions: ( 1 ) "Have you suffered @entity308 or @entity148 over the previous 12 months?" ( 2 ) "Has your medical doctor confirmed the diagnosis?" ( 3 ) "Have you consumed antidepressants prescribed by your physician over the last 2 weeks?" ( 4 ) "Have you consumed anxiolytics prescribed by your physician over the last 2 weeks?" Those who answered yes to questions 1, 2, and 3 or to all questions were considered " @entity308 sufferers," those who answered yes to questions 1, 2, and 4 were considered " @entity148 sufferers." We analyzed sociodemographic characteristics and health-related variables. RESULTS: Of the 28,966 subjects included in the study, 1650 were classified as @entity748 (5.6%). The prevalence of @entity148 was 9.7% among @entity1 with @entity565 and 6.6% among those without the disease (p < .01). After multivariate adjustment the probability of a subject suffering @entity148 was 1.27 (95% CI 1.08-1.49) higher among those with @entity565 than among those without. Independent and significantly associated variables with @entity148 among @entity748 @entity1 were older age, concomitant comorbidities, and visits to general practitioner in the last 4 weeks. The prevalence of @entity308 was 9% among @entity748 and 5.5% among those without the disease (p < .05). The multivariate adjustment revealed that suffering @entity308 was associated with suffering @entity565 (adjusted OR 1.39, 95% CI 1.18-1.64). Variables associated with @entity308 among @entity748 @entity1 were female sex, older age, worse self-related health, concomitant comorbidities, abstemious individuals, and the need for attendance on emergency room in the last year. CONCLUSIONS: Suffering @entity148 or @entity308 is associated with suffering @entity565 . Associated variables with @entity148 or @entity308 among @entity748 @entity1 include older age and concomitant comorbidities.

title: Psychiatric comorbidity in XXXX @entity1 . Associated factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic', 'asthmatics']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: OBJECTIVE: To study the prevalence of @entity148 and @entity308 in @entity1 with @entity565 and to identify associated factors. MATERIAL AND METHODS: The study was based on individual data of subjects aged >= 18 years drawn from the 2006 Spanish National Health Survey. We identified @entity748 individuals through a specific questionnaire. Presence of @entity308 or @entity148 was assessed using the following questions: ( 1 ) "Have you suffered @entity308 or @entity148 over the previous 12 months?" ( 2 ) "Has your medical doctor confirmed the diagnosis?" ( 3 ) "Have you consumed antidepressants prescribed by your physician over the last 2 weeks?" ( 4 ) "Have you consumed anxiolytics prescribed by your physician over the last 2 weeks?" Those who answered yes to questions 1, 2, and 3 or to all questions were considered " @entity308 sufferers," those who answered yes to questions 1, 2, and 4 were considered " @entity148 sufferers." We analyzed sociodemographic characteristics and health-related variables. RESULTS: Of the 28,966 subjects included in the study, 1650 were classified as @entity748 (5.6%). The prevalence of @entity148 was 9.7% among @entity1 with @entity565 and 6.6% among those without the disease (p < .01). After multivariate adjustment the probability of a subject suffering @entity148 was 1.27 (95% CI 1.08-1.49) higher among those with @entity565 than among those without. Independent and significantly associated variables with @entity148 among @entity748 @entity1 were older age, concomitant comorbidities, and visits to general practitioner in the last 4 weeks. The prevalence of @entity308 was 9% among @entity748 and 5.5% among those without the disease (p < .05). The multivariate adjustment revealed that suffering @entity308 was associated with suffering @entity565 (adjusted OR 1.39, 95% CI 1.18-1.64). Variables associated with @entity308 among @entity748 @entity1 were female sex, older age, worse self-related health, concomitant comorbidities, abstemious individuals, and the need for attendance on emergency room in the last year. CONCLUSIONS: Suffering @entity148 or @entity308 is associated with suffering @entity565 . Associated variables with @entity148 or @entity308 among @entity748 @entity1 include older age and concomitant comorbidities.

title: Psychiatric comorbidity in @entity565 XXXX . Associated factors.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The early forms of @entity2622 are meant to include in situ @entity189 of the portio and early-invasive @entity957 with 5 mm in maximum depth of invasion. Thirty-six pregnant @entity1 were admitted to the authors' department, between January 1st, 1970 and December 31st, 1978, who were between the forth and 20th weeks of pregnancy and had produced positive response to portio cell swab tests. The average age of the @entity1 was 28 years. All cytological findings had been histologically verified by conisation. Cerclage, according to Shirodkar, was applied prior to conisation to avoid excessive gestational bleeding from the conus bed, with attempts being made to obtain compression of the descending branch of the uterine vessels. The sections obtained from conisation gave the following histological results: moderate @entity1141 in ten @entity1 , severe @entity1141 of the Cervix of eight @entity1 , in situ @entity189 in 16 @entity1 , and beginning stroma invasion in terms of Ia collum @entity189 in two @entity1 . No abortion at all occurred to any of the @entity1 with such conisation in early pregnancy. Thirty-four @entity1 had no-complication vaginal deliveries. Caesarean section had to be applied to two @entity1 for @entity1468 or imminent intra-uterine @entity1763 . Conisation did not cause the occurrence of any @entity130 to the uterine cervix at the time of vaginal delivery.

title: [Diagnosis and therapy of 36 alleged early forms of XXXX in pregnancy (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['major injury']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous epithelium carcinoma']

entities_list: @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['EPH gestosis']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity2622 :: (MESH:D002583,Disease) :: ['cervical carcinoma']


abstract: BACKGROUND: @entity2543 is a pathology of the oral mucosa which has been reported in diverse ethnic groups. @entity1082 ) types 13 and 32 DNA has been detected in these lesions. The aims of this paper are to describe the epidemiological and clinical characteristics of an outbreak in a rural community in the Mayan area of Mexico and to identify a possible route of transmission through saliva. METHODS: A cross-sectional study was conducted in Chemax (Yucatan, Mexico). Clinical and epidemiological data were obtained through direct interviews. Samples of oral cells and saliva were taken. HPV 13 and 32 were identified by polymerase chain reaction using specific primers. RESULTS: A total of 57 @entity1 were studied, of whom 79.1% were aged <15 years, 38.6% were male, and 61.3% were female. The duration of lesions ranged from one month to 50 years. Lesions were located on the lips, @entity5932 , and more frequently, the tongue. HPV 13 was found in all the @entity1 and HPV 32 in none. A total of 42 saliva samples were positive for HPV 13. CONCLUSIONS: @entity1082 type 13 is involved in @entity2543 among the Mexican Mayan population. The presence of HPV 13 in cells from saliva, combined with poor hygiene behaviors, may explain the familial distribution of the pathology.

title: XXXX in a community in the Mayan area of Mexico.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2543 :: ('MESH:D017573', 'Disease') :: ['Multifocal epithelial hyperplasia', 'multifocal epithelial hyperplasia']

entities_list: @entity1082 :: ('10566', 'Species') :: ['Human papillomavirus', 'Human papillomavirus (HPV']

entities_list: @entity5932 :: ('MESH:C565008', 'Disease') :: ['jugal mucosa']

answer: @entity2543 :: (MESH:D017573,Disease) :: ['Multifocal epithelial hyperplasia']


abstract: Investigations were carried out on the binding of @entity14287 to purified (and reassociated) 70S ribosomes and 30S subunits from @entity3639 -susceptible strains, and the results were compared with those of similar studies with native (run-off) 70S ribosomes. At 0 C, only a small fraction of purified 70S ribosomes and 30S sub-units bound 1 molecule of the antibiotic tightly, and at a rate comparable to the binding occurring with native 70S ribosomes. At temperatures of 10 C and above, there was a temperature-dependent increase in the extent of antibiotic binding to purified 70S and 30S particles up to a maximum of 1 molecule/ribosomal particle, but the kinetics of binding was slow in comparison to that taking place at 0 C. These and other results suggest that a major fraction of 30S subunits and purified (or reassociated) 70S ribosomes are inactive in binding the antibiotic. This has been localized to an instability of the free 30S subunit, which in solution at 0 C has a half-life of 5 hr or less. Inactive 30S or 70S particles could be thermally activated, with the latter being identical in their @entity3639 -binding properties to native 70S ribosomes. The activation kinetics were slow in comparison to the binding kinetics for the antibiotic and were indicative of a conformational change in ribosomal structure. There thus appears to be a reversible transition between active and inactive forms of the ribosomal particles for @entity3639 binding, but additional binding sites for the antibiotic are not created by the transitions. The active form of the 30S subunit can be stabilized in the presence of @entity22878 , but much more effectively by association with the 50S subunit to form a 70S ribosome. The kinetics of @entity14287 binding were studied in both directions of the reaction, and the reaction in the direction of binding was found to be several orders of magnitude faster than that of the reverse, or debinding, direction. The kinetics of the exchange of bound @entity14287 with the free antibiotic were also determined and shown to have rate constants that are very similar to those of the debinding reaction, which is the rate-limiting step. It appears likely that the exchange reaction is proceeding via the same reaction pathway. The temperature dependence of the kinetics of dissociation of the bound complex was much greater than that in the direction of binding and accounted for most of the temperature dependence of the binding equilibrium. From the determined thermodynamic and activation parameters, it appears likely that binding of the antibiotic induces a conformational change in ribosomal structure to one that is less ordered than the native particle. Heterogeneity has been found in the kinetics of binding and of exchange, with a fraction of the 70S population showing slower kinetics for both directions of the reaction.

title: Binding of XXXX to Escherichia coli ribosomes: kinetics of the reaction.

entities_list: @entity3639 :: ('MESH:D013307', 'Chemical') :: ['streptomycin']

entities_list: @entity22878 :: ('CHEBI:73279', 'Chemical') :: ['polyuridylic acid']

entities_list: @entity14287 :: ('MESH:D004096', 'Chemical') :: ['dihydrostreptomycin']

answer: @entity14287 :: (MESH:D004096,Chemical) :: ['dihydrostreptomycin']


abstract: Fourteen @entity1 undergoing elective cesarean section were anesthetized with @entity4488 for induction and maintenance of anesthesia. Blood @entity4488 and serum inorganic @entity1388 levels were studied in the mothers at delivery and in the neonates at delivery and in the early neonatal period. Also neonatal urinary excretion of inorganic @entity1388 was determined. Renal function of the neonates was tested with a @entity1372 load at the age of 1 day. @entity4488 showed the expected distribution between mothers and neonates. The @entity4488 level of the neonates declined rapidly after delivery. Serum inorganic @entity1388 level increased significantly in the mothers from start of anesthesia until delivery. The neonatal level was lower and did not reach the level of neonates in areas with a high natural @entity1388 content in drinking water. The level of inorganic @entity1388 in urine was higher than the corresponding serum level, indicating an inorganic @entity1388 concentrating effect of the neonatal kidney. The difference between urinary excretion and serum content of inorganic @entity1388 showed neonatal metabolism of @entity4488 . The urinary @entity1372 excretion did not differ from that of @entity1 delivered without halogenated inhalation agents given to the mothers.

title: Anesthesia for cesarean section--VII. Early effects on neonatal renal function of XXXX anesthesia for cesarean section.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'infants']

entities_list: @entity4488 :: ('MESH:D004737', 'Chemical') :: ['Enflurane', 'enflurane']

entities_list: @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride']

answer: @entity4488 :: (MESH:D004737,Chemical) :: ['enflurane']


abstract: Chemical fractionation is a widely used tool for the chemical and toxicological characterization of complex mixtures. The objective of this research was to compare two frequently employed methods for fractionating a wood preserving waste (WPW) containing @entity2555 ( @entity2556 ) and @entity211 ( @entity212 ). The first method involved fractionation of the WPW into acid, base, and neutral fractions using a liquid-liquid acid/base/neutral (A/B/N) technique. The second method utilized @entity5383 column chromatography to produce two fractions, A1 and A2. Gas chromatography and mass spectrometry were used to quantify the chemical components in all fractions. The @entity5383 method recovered 473,338 mg of total @entity2556 (tPAHs) per kilogram crude, while the A/B/N method yielded only 193,379 mg tPAHs/kg crude. In contrast, the A/B/N method recovered 13.7 mg @entity212 /kg crude while the @entity5383 method yielded only 0.5 mg @entity212 /kg crude. Three bioassays were used to determine the @entity137 of the crude extract and fractions. The neutral and A1 fractions contained the highest levels of tPAHs and @entity3014 ( @entity3015 ) but failed to induce a positive response in the Salmonella/microsome assay with concentrations containing as much as 1800 and 2500 ng BaP/plate, respectively. In the @entity526 prophage induction assay, the acid fraction, which contained 472 mg @entity212 /kg fraction, induced a positive response, as did the base fraction, which did not contain detectable @entity212 . Significant reduction of gap junctional intercellular communication in hepatic cells occurred with the crude extract and acid, base, and neutral fractions. Overall, the results of these bioassays suggest that @entity212 genotoxicity was expressed in the acid fraction, whereas the cumulative genotoxicity of genotoxic @entity2556 appeared to be masked in the isolates from either fractionation method. The optimal fractionation method for a mixture of @entity16648 and @entity2556 may involve a refined hybrid method.

title: A comparison of two methods for fractionating complex mixtures in preparation for XXXX analysis.

entities_list: @entity211 :: ('MESH:D010416', 'Chemical') :: ['pentachlorophenol']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons']

entities_list: @entity16648 :: ('MESH:D002733', 'Chemical') :: ['chlorophenols']

entities_list: @entity3014 :: ('MESH:D001564', 'Chemical') :: ['benzo[a]pyrene']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity137 :: (MESH:D064420,Disease) :: ['toxicity']


abstract: A clinician is faced with several dilemmas when evaluating the asymptomatic individual. The first dilemma relates to 'who should be evaluated'. Generally the first step in evaluation is the exercise stress test (fig. 2). The following are guidelines that can be used to systematically evaluate the individual asymptomatic @entity1 who presents with a 'positive exercise stress test' (fig. 3). An ambulatory ECG can be performed to evaluate the occurrence and frequency of asymptomatic @entity308 and the response to @entity3362 . Isotope angiography and exercise 201Tl perfusion studies may provide additional information relating to the physiologic significance of asymptomatic @entity308 . If these studies are negative and the @entity1 ' 'positive stress test' was obtained at a high cardiac workload coupled with rapid normalization of the ST segment after exercise, and there was no change in the @entity308 after @entity1242 , a reasonable case can be made to simply observe the @entity1 . If the exercise test is 'positive' at a low cardiac workload, associated with prolonged @entity308 and/or a 'positive' exercise thallium or positive exercise angiography, or there was change in the @entity308 after @entity1242 or a lifethreatening @entity943 developed, coronary angiography seems warranted.

title: Detection and management of the asymptomatic XXXX with coronary artery disease.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['ST segment depression']

entities_list: @entity1242 :: ('MESH:D005996', 'Chemical') :: ['nitroglycerin']

entities_list: @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: Intravenous heparin therapy is often used in @entity1 presenting with @entity63 ( @entity63 ) or @entity64 as either bridging therapy for anticoagulation with @entity1229 , or as primary therapy in suspected intracranial @entity4066 , crescendo TIAs, or suspected hypercoagulable @entity3290 . We examined the use of a bolus of intravenous heparin at the start of anticoagulation during hospital admission for @entity1 with @entity63 or @entity64 . A subgroup analysis of a prospective, single-blinded, randomized clinical trial was undertaken to examine the effect of providing an intravenous bolus of heparin prior to continuous intravenous maintenance heparin therapy. Pre-treatment clinical factors were comparable between subgroups. Thirty-three @entity1 received a bolus at initiation of therapy and 173 @entity1 did not. @entity1 receiving a bolus had a significantly higher first activated partial thromboplastin time at 6 h after initiation of therapy than @entity1 without bolus (87.6 +/- 36.3 versus 61.0 +/- 8.1 s). @entity1 receiving bolus achieved an initial activated partial thromboplastin time greater than the minimum threshold for the therapeutic range of anticoagulation (> 60 s) sooner than @entity1 without bolus (9.6 +/- 7.3 versus 14.5 +/- 10.8 h), but did not have a significantly greater chance of achieving therapeutic range (60-90 s). The fraction of time during which anticoagulation was therapeutic was similar between @entity1 receiving bolus or not. There was no significant difference between the number of @entity3459 results, total dosage of intravenous heparin received, complications due to anticoagulation, nor the times required for discontinuation of heparin and discharge from hospital between subgroups. The use of an intravenous heparin bolus during initiation of anticoagulation for @entity63 or @entity64 does not appear to be associated with greater risks and can achieve a minimum therapeutic range faster than therapy without heparin bolus.

title: The use of a bolus of intravenous heparin while initiating heparin therapy in anticoagulation following @entity63 or XXXX does not lead to increased morbidity or mortality.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['transient ischemic attack', 'TIA']

entities_list: @entity1229 :: ('MESH:D014859', 'Chemical') :: ['warfarin']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['supratherapeutic coagulation']

entities_list: @entity4066 :: ('MESH:D020217', 'Disease') :: ['arterial dissection']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: Intravenous heparin therapy is often used in @entity1 presenting with @entity63 ( @entity63 ) or @entity64 as either bridging therapy for anticoagulation with @entity1229 , or as primary therapy in suspected intracranial @entity4066 , crescendo TIAs, or suspected hypercoagulable @entity3290 . We examined the use of a bolus of intravenous heparin at the start of anticoagulation during hospital admission for @entity1 with @entity63 or @entity64 . A subgroup analysis of a prospective, single-blinded, randomized clinical trial was undertaken to examine the effect of providing an intravenous bolus of heparin prior to continuous intravenous maintenance heparin therapy. Pre-treatment clinical factors were comparable between subgroups. Thirty-three @entity1 received a bolus at initiation of therapy and 173 @entity1 did not. @entity1 receiving a bolus had a significantly higher first activated partial thromboplastin time at 6 h after initiation of therapy than @entity1 without bolus (87.6 +/- 36.3 versus 61.0 +/- 8.1 s). @entity1 receiving bolus achieved an initial activated partial thromboplastin time greater than the minimum threshold for the therapeutic range of anticoagulation (> 60 s) sooner than @entity1 without bolus (9.6 +/- 7.3 versus 14.5 +/- 10.8 h), but did not have a significantly greater chance of achieving therapeutic range (60-90 s). The fraction of time during which anticoagulation was therapeutic was similar between @entity1 receiving bolus or not. There was no significant difference between the number of @entity3459 results, total dosage of intravenous heparin received, complications due to anticoagulation, nor the times required for discontinuation of heparin and discharge from hospital between subgroups. The use of an intravenous heparin bolus during initiation of anticoagulation for @entity63 or @entity64 does not appear to be associated with greater risks and can achieve a minimum therapeutic range faster than therapy without heparin bolus.

title: The use of a bolus of intravenous heparin while initiating heparin therapy in anticoagulation following XXXX or @entity64 does not lead to increased morbidity or mortality.

answer: @entity63 :: (MESH:D007511,Disease) :: ['transient ischemic attack']


abstract: OBJECTIVE: To evaluate the results of partial and total ossicular reconstruction prostheses entirely made of @entity692 . STUDY DESIGN: A retrospective review of cases followed-up between 1997 and 2000. SETTING: Tertiary referral center. @entity1 : One hundred adult @entity1 (60 @entity1 and 40 @entity1 ) were studied. The mean age was 55 years (range, 25 to 65 years). Fifty @entity1 had a previous tympanoplasty. The series included 45 @entity3540 (45%), 37 @entity2172 without @entity3540 (37%), 13 retraction pockets (13%), and 5 posttraumatic ossicular displacements (5%). INTERVENTION: A one-stage ossiculoplasty with a partial ossicular reconstruction prosthesis (n = 65) or a total ossicular reconstruction prosthesis (n = 35) was performed. This was associated with a simple mastoidectomy in 70 cases and a radical mastoidectomy in 10 cases. MAIN OUTCOME MEASURES: All @entity1 were followed-up at 1 year, and 50 were reexamined 2 years after surgery. Clinical and audiometric data were collected in a database at each visit. RESULTS: A prosthetic extrusion was noted in two cases (2%). A prosthetic displacement occurred in 10 cases (10%). A revision surgery was carried out in 10 cases because of an ossiculoplasty failure or a disease recurrence. At 1 year, the residual air-bone gap was lower in cases with a partial ossicular reconstruction prosthesis than those with a total ossicular reconstruction prosthesis (16 +/- 9.3 versus 23 +/- 13.7 dB, p < 0.05). The gain in mean air conduction threshold was 21 +/- 12.8 dB in cases of partial ossicular reconstruction prosthesis and 19 +/- 11.3 dB in cases of total ossicular reconstruction prosthesis (not significant). Revision surgery, canal wall-down mastoidectomy, or @entity3540 yielded poorer functional results. CONCLUSION: Partial ossicular reconstruction prosthesis and total ossicular reconstruction prosthesis entirely made of dense @entity692 yielded high rates of air-bone gap reduction and high anatomic stability.

title: Ossiculoplasty with total XXXX prostheses anatomical and functional outcomes.

entities_list: @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxylapatite']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'men']

entities_list: @entity3540 :: ('MESH:D002781', 'Disease') :: ['cholesteatomas', 'cholesteatoma']

entities_list: @entity2172 :: ('MESH:D010033', 'Disease') :: ['chronic otitis media']

answer: @entity692 :: (MESH:D017886,Chemical) :: ['hydroxylapatite']


abstract: BACKGROUND: The failure of cricothyroid approximation in male-to-female-transsexuals--as described by Isshiki--is often caused by suture cutting through the cartilage early postoperatively. At this stage there is no stabilized scarring and the previously approximated edges of the cartilage can drift apart, lowering the voice pitch through reduction of the tension of the vocal cords. The cartilage can be protected from cutting injuries of the wire sutures by using mini plates made of either @entity702 or LactoSorb. The present study examined the influence of the different materials on the result. @entity1 AND METHODS: A cricothyroidopexy in male-to-female-transsexuals was performed in 67 @entity1 between October 1993 and December 2001. The medium age was 39 years, ranging from 24 to 67 years. For stabilizing the thyroid and cricoid cartilage @entity702 mini plates were used in 28 @entity1 (41.8 %) and LactoSorb mini plates in 39 (58.2 %). A complete voice diagnostic work-up was performed pre- and postoperatively. RESULTS AND CONCLUSIONS: In 94 % of all @entity1 the medium speaking voice could be raised on average by five half tones through the increased tension of the vocal cords. In 39 % very good (rise by more than 12 half tones) and good (rise by six to 12 half tones) results could be achieved, while in 55 % a minimal (one to two half tones) or very small (three to five half tones) rise was noted. The material of the mini plates had no impact on the degree of voice pitch raising, the long-term results or the number of revision surgeries.

title: [Resorbable material for osteosynthesis or XXXX for the cricothyroidopexy?].

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients']

answer: @entity702 :: (MESH:D014025,Chemical) :: ['titanium']


abstract: BACKGROUND _ AIMS: Studies of antidepressants and @entity29 ( @entity29 ) are methodologically limited. The aim of this study was to assess the clinical efficacy and safety of cognitive-behavioral therapy (CBT) against education (EDU) and @entity5829 ( @entity4743 ) against placebo ( @entity1989 ) in female @entity1 with moderate to severe @entity29 ( @entity1744 , functional @entity490 , painful @entity1142 , and unspecified @entity29 ). We also evaluated the amenability of clinically meaningful subgroups to these treatments. METHODS: This randomized, comparator-controlled, multicenter trial enrolled 431 adults from the University of North Carolina and the University of Toronto with moderate to severe symptoms of @entity29 . @entity1 received psychological (CBT vs. EDU) or antidepressant ( @entity4743 vs. @entity1989 ) treatment for 12 weeks. Clinical, physiologic, and psychosocial assessments were performed before and at the end of treatment. RESULTS: The intention-to-treat analysis showed CBT as significantly more effective than @entity10081 (P = 0.0001; responder rate, 70% CBT vs. 37% EDU; number needed to treat [NNT ], 3.1). @entity4743 did not show significant benefit over @entity1989 in the intention-to-treat analysis (P = 0.16; responder rate, 60% @entity4743 vs. 47% @entity1989 ; NNT, 8.1) but did show a statistically significant benefit in the per-protocol analysis (P = 0.01; responder rate, 73% @entity4743 vs. 49% @entity1989 ; NNT, 5.2), especially when @entity1 with nondetectable blood levels of @entity4743 were excluded (P = 0.002). Improvement was best gauged by satisfaction with treatment. Subgroup analyses showed that @entity4743 was beneficial over @entity1989 for moderate more than severe symptoms, abuse history, no @entity308 , and @entity294 -predominant symptoms; CBT was beneficial over EDU for all subgroups except for @entity308 . CONCLUSIONS: For female @entity1 with moderate to severe @entity29 , CBT is effective and @entity4743 may be effective when taken adequately. Certain clinical subgroups are more or less amenable to these treatments.

title: Cognitive-behavioral therapy versus education and XXXX versus placebo for moderate to severe @entity29 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity5829 :: ('MESH:D003891', 'Chemical') :: ['desipramine']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['psychological treatments in functional bowel disorders', 'FBD']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome']

answer: @entity5829 :: (MESH:D003891,Chemical) :: ['desipramine']


abstract: BACKGROUND _ AIMS: Studies of antidepressants and @entity29 ( @entity29 ) are methodologically limited. The aim of this study was to assess the clinical efficacy and safety of cognitive-behavioral therapy (CBT) against education (EDU) and @entity5829 ( @entity4743 ) against placebo ( @entity1989 ) in female @entity1 with moderate to severe @entity29 ( @entity1744 , functional @entity490 , painful @entity1142 , and unspecified @entity29 ). We also evaluated the amenability of clinically meaningful subgroups to these treatments. METHODS: This randomized, comparator-controlled, multicenter trial enrolled 431 adults from the University of North Carolina and the University of Toronto with moderate to severe symptoms of @entity29 . @entity1 received psychological (CBT vs. EDU) or antidepressant ( @entity4743 vs. @entity1989 ) treatment for 12 weeks. Clinical, physiologic, and psychosocial assessments were performed before and at the end of treatment. RESULTS: The intention-to-treat analysis showed CBT as significantly more effective than @entity10081 (P = 0.0001; responder rate, 70% CBT vs. 37% EDU; number needed to treat [NNT ], 3.1). @entity4743 did not show significant benefit over @entity1989 in the intention-to-treat analysis (P = 0.16; responder rate, 60% @entity4743 vs. 47% @entity1989 ; NNT, 8.1) but did show a statistically significant benefit in the per-protocol analysis (P = 0.01; responder rate, 73% @entity4743 vs. 49% @entity1989 ; NNT, 5.2), especially when @entity1 with nondetectable blood levels of @entity4743 were excluded (P = 0.002). Improvement was best gauged by satisfaction with treatment. Subgroup analyses showed that @entity4743 was beneficial over @entity1989 for moderate more than severe symptoms, abuse history, no @entity308 , and @entity294 -predominant symptoms; CBT was beneficial over EDU for all subgroups except for @entity308 . CONCLUSIONS: For female @entity1 with moderate to severe @entity29 , CBT is effective and @entity4743 may be effective when taken adequately. Certain clinical subgroups are more or less amenable to these treatments.

title: Cognitive-behavioral therapy versus education and @entity5829 versus placebo for moderate to severe XXXX .

answer: @entity29 :: (MESH:D015212,Disease) :: ['functional bowel disorders']


abstract: PURPOSE: To investigate the rate, clinical features, treatment outcomes and prognosis of @entity3225 . METHODS: @entity1 undergoing pars plana vitrectomy for vitreous @entity231 or complicated retinal detachment during 1988 to 2000 were collected. Vitrectomies for recent penetrating @entity130 or @entity3225 were excluded. @entity1 suffered from clinical or culture-proven @entity3225 were selected. RESULTS: @entity3225 happened to 3 to 7,000 @entity1 , resulting in an overall frequency of 0.04%. Enhanced systemic and local antibiotics were used as soon as diagnosis was made. Endophthamitis were controlled within 6 days, 8 days and 10 days, respectively. Final visual acuities were light perception in 2 @entity1 and 0.02 in 1 @entity1 . CONCLUSION: @entity3225 was rare, but it deteriorate the visual acuity. Both ophthalmologist and @entity1 should pay high attention to it.

title: Clinical features of XXXX after vitreoretinal surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity3225 :: ('MESH:D009877', 'Disease') :: ['Postvitrectomy endophthalmitis', 'postvitrectomy endophthalmitis', 'endophthalmitis']

answer: @entity3225 :: (MESH:D009877,Disease) :: ['endophthalmitis']


abstract: The clinical and pathological features of 40 @entity8302 of the testis were analyzed. The @entity1 ranged from 2 to 90 (average 46.5) years of age. The most common initial manifestation was @entity4 , which was sometimes associated with @entity247 ; 15% of the @entity1 presented because of @entity247 and were found to have palpable @entity5 . All three @entity1 were brought to the physician because of isosexual pseudoprecocity. The @entity5 , one of which was asynchronously bilateral, ranged from 0.5 to 10.0 (average 3) cm in greatest diameter. They were usually well circumscribed, but in seven of them the margin with the adjacent testis was ill-defined. On microscopic examination the most common pattern was that of diffuse sheets of neoplastic cells, but insular, trabecular, pseudotubular, and ribbon-like patterns were also encountered. The neoplastic cells were most often large and polygonal with abundant eosinophilic, slightly granular cytoplasm; occasionally the cytoplasm was abundantly vacuolated. In @entity5 some of the cells were spindle-shaped, and in six some had scanty cytoplasm. Crystalloids of Reinke were identified in 35% of the @entity5 . Conspicuous nuclear atypicality was present in 12 @entity5 and the mitotic rate ranged from less than 1 to 32/10 high-power fields. Blood vessel invasion, lymphatic invasion, or both were identified in four @entity5 . Follow-up of 2 months to 22 years (average 4 years) was available for 30 @entity1 . Five of them died as a result of spread of their @entity5 . A comparison of the clinically @entity5 with those associated with survival for 2 or more years postoperatively revealed that the former occurred in older @entity1 and were accompanied by symptoms of shorter duration and an absence of endocrine manifestations. The @entity5 were larger, often had an infiltrative margin and had spread beyond the testis, frequently exhibited blood vessel or lymphatic invasion, and had a greater degree of cellular atypia and @entity39 and a higher mitotic rate than the @entity5 .

title: XXXX of the testis. A clinicopathological analysis of 40 cases and review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'eight tumors', 'malignant tumors', 'benign tumors', 'testicular tumors', 'tumors']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['testicular swelling']

entities_list: @entity247 :: ('MESH:D006177', 'Disease') :: ['gynecomastia']

entities_list: @entity8302 :: ('MESH:D007984', 'Disease') :: ['Leydig cell tumors']

answer: @entity8302 :: (MESH:D007984,Disease) :: ['Leydig cell tumors']


abstract: BACKGROUND: The aim of this study was to analyze the outcome after the surgical treatment of @entity1 with malignant @entity75 , as well as the factors influencing the outcome. Retrospective study was performed on 145 operated @entity1 (102 with @entity463 multiforme, and 43 with @entity816 ). METHODS: Clinical state was graded according to the Yasargil scale (grades I-IV) and the Karnofski score, and the outcome was defined either as good (better or unchanged clinical state) or as poor (deteriorated state or @entity204 ). The outcome was correlated with @entity1 age and preoperative clinical condition, as well as with the localization, extensiveness and the extent of resection of the @entity5 . RESULTS: Preoperative clinical state of @entity1 most frequently corresponded to grades II-III (75.9%). Radical resection was done in 48.3%, subtotal in 15.2%, partial in 30.3%, and biopsy was performed in 6.2% of @entity1 , with the total operative mortality of 16.5%, morbidity of 9.7%, and good postoperative outcome in 73.8% of the @entity1 . The incidence of good postoperative outcome did not significantly depend on the @entity5 location (42.6-78.3%), cortical presentation, the extent of resection (68.2-75.7%), and preoperative clinical state (67.8-81.5%). Good outcome was seen in 82.7% of @entity1 with one, and in 53.8% of @entity1 with three or more infiltrated lobes (p < 0.01). @entity1 with poor outcome were significantly older in average than the @entity1 with good outcome (58.9 +/- 12.1 and 50.9 +/- 13.4 years of age, respectively; p < 0.05). Operative mortality was 7.4%, and 27.3% for clinical grades II and IV (p < 0.05), namely 11% and 23.8% for the @entity1 with the Karnofski score above and under 50 (p < 0.05), respectively. CONCLUSION: The outcome after the operative treatment of malignant @entity816 significantly depended on @entity1 age and the extensity of the @entity5 . For such @entity1 operative mortality was also significantly influenced by clinical preoperative state.

title: [Outcome of surgical treatment of malignant XXXX of the brain].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain astrocytomas']

entities_list: @entity816 :: ('MESH:D001254', 'Disease') :: ['anaplastic astrocytomas', 'cerebral astrocytomas']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']

answer: @entity816 :: (MESH:D001254,Disease) :: ['astrocytoma']


abstract: There are differing opinions regarding the cause of @entity169 in adults. It seems that a patent vaginal process may determine the type of herniation that occurs in an adult but may not actually cause the @entity547 . Also, altered collagen metabolism seems to play a significant role in many cases of @entity547 in adults. Thus, most of these @entity547 are actually caused by a mixture of congenital and acquired factors. Consequently, it follows that there are a variety of opinions regarding surgical repair. This follow-up study on recurrence after @entity169 repair in Saudi Arabia was aimed at testing the effectiveness of Bassini's repair and the results achieved when it is employed for primary @entity169 repair in adults. One hundred forty @entity1 (95 with indirect and 45 with direct @entity547 ) who had Bassini's repair were studied. Only pure direct or indirect @entity547 were included. Combined direct, indirect bilateral, recurrent, or @entity18659 were not investigated. All the @entity1 were followed for 2 years after repair, with a total recurrence rate of 2.14 percent. The projected recurrence rate at 25 years is 5.3 percent. These results are comparable to those achieved with other techniques. Therefore, I believe that the criticisms of Bassini's repair are based on theoretic grounds only. Bassini's repair has stood the test of time, is easier to teach and to perform by junior surgeons, and the chance of being complicated by @entity2268 and @entity1151 is less than the chance with Cooper's ligament repair.

title: XXXX in Saudi Arabia. A 10 year experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2268 :: ('MESH:D013924', 'Disease') :: ['thrombophlebitis']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity18659 :: ('MESH:D006550', 'Disease') :: ['femoral hernias']

entities_list: @entity547 :: ('MESH:D006547', 'Disease') :: ['hernia', 'hernias']

entities_list: @entity169 :: ('MESH:D006552', 'Disease') :: ['inguinal hernias', 'inguinal hernia']

answer: @entity169 :: (MESH:D006552,Disease) :: ['Inguinal hernia']


abstract: In the gill epithelium of the @entity14994 @entity14994 a mitochondria-rich cell type is described which ultrastructurally resembles the @entity2865 cells in other fish species. Freeze-fracture replicas reveal different supramolecular structures in the luminal plasma membrane and in the intracellular amplification (tubular system) of the basolateral plasma membrane of these mitochondria-rich cells. In the luminal plasma membrane ordered assemblies of particles and fibril-like elements are regularly found. On the P face, the assemblies are composed of up to 20 linear arrays of particles which are preferentially located in the microvillar membrane on which they show a helicoidal orientation. The arrays are formed by globular (diameter 8-9 nm) and rod-shaped (length 16-20 nm) particles, which occasionally are so tightly end-to-end attached that they generate fibril-like structures. The distances between adjacent arrays within an assembly measure 10-15 nm. On the E face complementary patterns of linear grooves are present. These assemblies have not previously been demonstrated in the freeze-fractured plasma membrane of branchial @entity2865 cells. In the membrane of the tubular system, emerging from the basolateral plasma membrane of the mitochondria-rich cells, infrequently repeating rows of 7-8 nm particles are present in addition to randomly distributed globular particles (diameter 7-8 nm). Complementary patterns of grooves are present on the E face. These intramembranous structures resemble the repetitive elements which have been previously described in the tubular system of branchial @entity2865 cells in euryhaline teleosts and the subunits of which are considered to be the sites of ion pumps.

title: Assemblies of linear arrays of particles in the apical plasma membrane of mitochondria-rich cells in the gill epithelium of the XXXX ( @entity14994 ).

entities_list: @entity14994 :: ('7769', 'Species') :: ['Myxine glutinosa', 'Atlantic hagfish']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

answer: @entity14994 :: (7769,Species) :: ['Atlantic hagfish']


abstract: In the gill epithelium of the @entity14994 @entity14994 a mitochondria-rich cell type is described which ultrastructurally resembles the @entity2865 cells in other fish species. Freeze-fracture replicas reveal different supramolecular structures in the luminal plasma membrane and in the intracellular amplification (tubular system) of the basolateral plasma membrane of these mitochondria-rich cells. In the luminal plasma membrane ordered assemblies of particles and fibril-like elements are regularly found. On the P face, the assemblies are composed of up to 20 linear arrays of particles which are preferentially located in the microvillar membrane on which they show a helicoidal orientation. The arrays are formed by globular (diameter 8-9 nm) and rod-shaped (length 16-20 nm) particles, which occasionally are so tightly end-to-end attached that they generate fibril-like structures. The distances between adjacent arrays within an assembly measure 10-15 nm. On the E face complementary patterns of linear grooves are present. These assemblies have not previously been demonstrated in the freeze-fractured plasma membrane of branchial @entity2865 cells. In the membrane of the tubular system, emerging from the basolateral plasma membrane of the mitochondria-rich cells, infrequently repeating rows of 7-8 nm particles are present in addition to randomly distributed globular particles (diameter 7-8 nm). Complementary patterns of grooves are present on the E face. These intramembranous structures resemble the repetitive elements which have been previously described in the tubular system of branchial @entity2865 cells in euryhaline teleosts and the subunits of which are considered to be the sites of ion pumps.

title: Assemblies of linear arrays of particles in the apical plasma membrane of mitochondria-rich cells in the gill epithelium of the @entity14994 ( XXXX ).

answer: @entity14994 :: (7769,Species) :: ['Myxine glutinosa']


abstract: UNASSIGNED: The authors aimed at analyzing the costs of inpatient care of @entity161 in Kiel (Germany). The study was also to present treatment regimens used at the German Academic Center. Moreover, the study is a continuation and complement of the previous study conducted in Polish and Ukrainian Academic Center. Therefore, it helps increase the awareness and knowledge of residents concerning the cost of inpatient care of @entity161 . The analysis was based on 105 hospital records of @entity1 treated between January 2012 and June 2013. According to inclusion criteria, 50 adult @entity1 (27 @entity1 and 23 @entity1 ) were included in the study. The study was approved by the Ethics Committee of the Medicine Faculty of CAU in Kiel. The cost of @entity161 treatment of 50 @entity1 in Kiel was EUR 604,280.90 ([Formula: see text]  =  EUR 12,085.62). The duration of hospital stay was on average [Formula: see text]  =  51.02  days. The @entity1 were treated with neuroleptics of all generations. The most popular atypical neuroleptic was @entity14867 and the most popular typical neuroleptic was @entity1767 . @entity1 from Kiel were provided a comprehensive non-pharmacological treatment. Treatment regiments and evaluations of costs of @entity161 vary between countries. The costs of inpatient care of @entity161 are high in Kiel. Treatment of @entity161 seems to be comprehensive in Kiel and wide range of treatment opportunities contribute to a more effective treatment confirmed by less frequent relapses of @entity161 than in Lviv (Ukraine), for example. Comprehensive treatment should be available everywhere, because it is a right of every @entity1 .

title: The Cost of Inpatient Care of XXXX and Treatment Schedules Used in German Academic Center: Kiel.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'men']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity1767 :: ('MESH:D006220', 'Chemical') :: ['haloperidol']

entities_list: @entity14867 :: ('MESH:C012052', 'Chemical') :: ['amisulpride']

answer: @entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']


abstract: UNASSIGNED: We evaluated the clinical utility of screening for mutations in 34 @entity5344 susceptibility genes in high-risk families in Israel. @entity1 were recruited from 12, 2012 to 6, 2015 from 8 medical centers. All @entity1 had high @entity5344 risk based on personal and family history. Genotyping was performed with the InVitae    platform. The study was approved by the ethics committees of the participating centers; all @entity1 gave a written informed consent before entering the study. Overall, 282 individuals participated in the study: 149 (53  %) of Ashkenazi descent, 80 (28  %) Jewish non-Ashkenazi descent, 22 (8  %) of mixed Ashkenazi/non-Ashkenazi origin, 21 (7  %) were non-Jewish Caucasians, and the remaining @entity1 (n  =  10-3.5  %) were of Christian Arabs/Druze/unknown ethnicity. For @entity0 @entity1 (n  =  165), the median (range) age at diagnosis was 46 (22-90) years and for @entity43 (n  =  15) 54 (38-69) years. Overall, 30 cases (10.6  %) were found to carry a pathogenic actionable mutation in the tested genes: 10 @entity5345 (3 non-founder mutations), 9 @entity2674 (8 non-founder mutations), and one each in the @entity24717 and @entity9516 genes. Furthermore, actionable mutations were detected in 9 more cases in 4 additional genes ( @entity4311 , @entity8958 , @entity4638 , and @entity1412 ). No pathogenic mutations were detected in the other genotyped genes. In this high-risk population, 10.6  % harbored an actionable pathogenic mutation, including non-founder mutations in @entity6069 and in additional @entity5 susceptibility genes, suggesting that high-risk families should be genotyped and be assigned a genotype-based @entity5 risk.

title: Screening for germline mutations in XXXX susceptibility genes in high-risk families in Israel.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5344 :: ('MESH:D061325', 'Disease') :: ['breast/ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity5344 :: (MESH:D061325,Disease) :: ['breast/ovarian cancer']


abstract: OBJECTIVE: @entity1 with left ventricular (LV) @entity67 are characterized by exertional dyspnoea. Heart rate (HR) reduction by b-blockers can improve exercise tolerance by prolonging LV filling, but their negative inotropic and lusitropic properties can be detrimental in this disease. We tested the effects of administering @entity15726 , a HR-lowering drug without impact on cardiac kinetics that may favorably affect diastolic function. METHODS: Twenty-four @entity1 with @entity453 ( @entity453 ) and normal LV ejection fraction on chronic b-blocker therapy were included. NT-proBNP serum levels were determined prior to and after cardiopulmonary exercise. b-Blockers were then replaced by @entity15726 and @entity1 were re-tested after 6 weeks. @entity1 were initially classified as having a low (E/e'   <=  8; n  =  11) or high (E/e'  >  8; n  =  13) LV filling index. RESULTS: E/e' significantly decreased during @entity15726 therapy in @entity1 with high E/e' (10.7      2.9 vs. 8.9      1.7; p  <  0.01), whereas no difference occurred in @entity1 with low E/e' (6.4      0.7 vs. 6.5      1.1; p  =  ns). With @entity15726 , @entity1 with high E/e' had an increased @entity26 uptake at the anaerobic threshold (from 10.8      1.4 to 11.8      1.9  ml/min/kg; p  <  0.05) and a steeper slope of the initial @entity26 pulse curve (from 293      109 to 359      117    l/beat/kg/W; p  <  0.05). Moreover, @entity1 with high E/e' had lower NT-proBNP serum levels at rest (169      207 vs. 126      146  pg/ml; p  <  0.05) and after exercise (190      256 vs. 136      162  pg/ml; p  <  0.05) during @entity15726 therapy. CONCLUSIONS: In @entity1 with @entity453 and elevated E/e', switching therapy from b-blockers to @entity15726 may cause a reduction in LV filling pressures and an improved @entity64 volume response to exercise.

title: b-Blockers and XXXX differentially affect cardiopulmonary function and left ventricular filling index.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction']

entities_list: @entity15726 :: ('MESH:C088408', 'Chemical') :: ['ivabradine']

answer: @entity15726 :: (MESH:C088408,Chemical) :: ['ivabradine']