abstract: Recently, we observed a case of lumbar @entity1317 after @entity130 , which was treated by endovascular embolization. A 67-year-old @entity1 who was injured in a traffic accident was brought to the emergency room. She was conscious and her hemodynamic condition was stable, but she had @entity451 below L1 dermatome. Contrast-enhanced computed tomography scan of abdomen and pelvis revealed @entity174 of L3/4 along with retroperitoneal @entity1410 . However, there was no evidence of @entity130 in both thoracic and abdominal cavity. At that time, her blood pressure suddenly decreased to 60/40 mmHg and her mental status deteriorated. Also, her hemoglobin level was 5.4 g/dl. While her hemodynamic condition stabilized with massive fluid resuscitation including blood transfusion, an angiography was immediately performed to look for and embolize site of retroperitoneal @entity548 . On the angiographic images, there was an active extravasation from ruptured left 3rd lumbar artery, and we performed complete embolization with GELFOAM and coil. Lumbar @entity1317 after @entity130 is rare and endovascular treatment is useful in case of @entity1344 .

title: Traumatic lumbar artery rupture after lumbar spinal XXXX causing hypovolemic shock: An endovascular treatment.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture dislocation']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas']

entities_list: @entity1344 :: ('MESH:D043171', 'Disease') :: ['hemodynamic instability']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['artery injury']

entities_list: @entity451 :: ('MESH:C536857', 'Disease') :: ['paraplegia']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury', 'trauma']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture dislocation']


abstract: @entity12472 ( @entity10664 ), an s- @entity21750 herbicide, is a widespread environmental contaminant. The hepatocarcinogenic component of technical grade @entity53172 , @entity41553 ( @entity41554 , 19.5%), is a byproduct of @entity51224 synthesis and is found at production sites. This study explores the effect of @entity10664 treatment on the bioactivation of the promutagen, @entity41554 . Male Fischer 344 @entity35 (5 weeks old) were administered 50 mg/kg of @entity10664 by gavage for 5 weeks. At 1, 3, and 5 weeks, both DMSO-control and @entity10664 -pretreated @entity35 were treated p.o. with 75 mg/kg of @entity41554 and were housed in metabolism cages for urine collection. Sulfatase- and beta-glucuronidase-treated, concentrated urine was bioassayed for urinary mutagens in a microsuspension modification of the Salmonella assay with and without metabolic activation. No significant change in mutagen excretion was observed in @entity10664 -treated @entity35 ; however, an elevation in direct-acting urine mutagens from @entity35 receiving @entity10664 and @entity41554 at weeks 1 (359 +/- 68 vs. 621 +/- 96 revertants/ml) and 5 (278 +/- 46 vs. 667 +/- 109 revertants/ml) of treatment was observed. The increase in production of urinary mutagens was accompanied by an elevation in small intestinal nitroreductase activity. Increases in large intestinal nitroreductase and beta-glucuronidase were observed after 5 weeks. There was no apparent effect of @entity10664 following 5 weeks of treatment on the production of @entity41554 -derived hepatic DNA adducts. @entity10664 treatment modifies intestinal enzymes responsible for promutagen bioactivation, and potentiates the excretion of mutagenic urine in @entity41554 -treated animals.

title: @entity12472 treatment potentiates excretion of mutagenic urine in XXXX -treated Fischer 344 @entity35 .

entities_list: @entity21750 :: ('CHEBI:38056', 'Chemical') :: ['triazine']

entities_list: @entity41553 :: ('MESH:C023514', 'Chemical') :: ['2,6-dinitrotoluene']

entities_list: @entity51224 :: ('MESH:D014303', 'Chemical') :: ['trinitrotoluene']

entities_list: @entity53172 :: ('CHEBI:23822', 'Chemical') :: ['dinitrotoluene']

answer: @entity41553 :: (MESH:C023514,Chemical) :: ['2,6-dinitrotoluene']


abstract: @entity12472 ( @entity10664 ), an s- @entity21750 herbicide, is a widespread environmental contaminant. The hepatocarcinogenic component of technical grade @entity53172 , @entity41553 ( @entity41554 , 19.5%), is a byproduct of @entity51224 synthesis and is found at production sites. This study explores the effect of @entity10664 treatment on the bioactivation of the promutagen, @entity41554 . Male Fischer 344 @entity35 (5 weeks old) were administered 50 mg/kg of @entity10664 by gavage for 5 weeks. At 1, 3, and 5 weeks, both DMSO-control and @entity10664 -pretreated @entity35 were treated p.o. with 75 mg/kg of @entity41554 and were housed in metabolism cages for urine collection. Sulfatase- and beta-glucuronidase-treated, concentrated urine was bioassayed for urinary mutagens in a microsuspension modification of the Salmonella assay with and without metabolic activation. No significant change in mutagen excretion was observed in @entity10664 -treated @entity35 ; however, an elevation in direct-acting urine mutagens from @entity35 receiving @entity10664 and @entity41554 at weeks 1 (359 +/- 68 vs. 621 +/- 96 revertants/ml) and 5 (278 +/- 46 vs. 667 +/- 109 revertants/ml) of treatment was observed. The increase in production of urinary mutagens was accompanied by an elevation in small intestinal nitroreductase activity. Increases in large intestinal nitroreductase and beta-glucuronidase were observed after 5 weeks. There was no apparent effect of @entity10664 following 5 weeks of treatment on the production of @entity41554 -derived hepatic DNA adducts. @entity10664 treatment modifies intestinal enzymes responsible for promutagen bioactivation, and potentiates the excretion of mutagenic urine in @entity41554 -treated animals.

title: XXXX treatment potentiates excretion of mutagenic urine in @entity41553 -treated Fischer 344 @entity35 .

answer: @entity12472 :: (MESH:D001280,Chemical) :: ['Atrazine']


abstract: @entity12472 ( @entity10664 ), an s- @entity21750 herbicide, is a widespread environmental contaminant. The hepatocarcinogenic component of technical grade @entity53172 , @entity41553 ( @entity41554 , 19.5%), is a byproduct of @entity51224 synthesis and is found at production sites. This study explores the effect of @entity10664 treatment on the bioactivation of the promutagen, @entity41554 . Male Fischer 344 @entity35 (5 weeks old) were administered 50 mg/kg of @entity10664 by gavage for 5 weeks. At 1, 3, and 5 weeks, both DMSO-control and @entity10664 -pretreated @entity35 were treated p.o. with 75 mg/kg of @entity41554 and were housed in metabolism cages for urine collection. Sulfatase- and beta-glucuronidase-treated, concentrated urine was bioassayed for urinary mutagens in a microsuspension modification of the Salmonella assay with and without metabolic activation. No significant change in mutagen excretion was observed in @entity10664 -treated @entity35 ; however, an elevation in direct-acting urine mutagens from @entity35 receiving @entity10664 and @entity41554 at weeks 1 (359 +/- 68 vs. 621 +/- 96 revertants/ml) and 5 (278 +/- 46 vs. 667 +/- 109 revertants/ml) of treatment was observed. The increase in production of urinary mutagens was accompanied by an elevation in small intestinal nitroreductase activity. Increases in large intestinal nitroreductase and beta-glucuronidase were observed after 5 weeks. There was no apparent effect of @entity10664 following 5 weeks of treatment on the production of @entity41554 -derived hepatic DNA adducts. @entity10664 treatment modifies intestinal enzymes responsible for promutagen bioactivation, and potentiates the excretion of mutagenic urine in @entity41554 -treated animals.

title: @entity12472 treatment potentiates excretion of mutagenic urine in @entity41553 -treated Fischer 344 XXXX .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: Targeted PCR-based genetic testing for @entity5345 and @entity2674 can be performed at a lower cost than full gene testing; however, it does not detect mutations responsible for @entity5344 . In the present study, we report the utility of next generation sequencing (NGS) to identify new pathogenic variants of @entity6069 . METHODS: @entity5345 and @entity2674 exons were amplified using the Ion AmpliSeq @entity6069 Panel and sequenced on the Ion Torrent PGM sequencer in 512 @entity1 with familial and/or only early onset @entity5344 who were negative for selected @entity5345 /2 mutations. RESULTS: 146 single @entity4334 variants (SNVs) and 32 indels were identified. Of them, 14 SNVs and 17 indels were considered as pathogenic or likely pathogenic. One and 18 pathogenic mutations had been detected previously in the Polish and other populations, respectively, and 12 deleterious mutations were previously unknown. Eight mutations were recurrent; @entity71860 ( @entity5345 ), N3124I ( @entity2674 ) and @entity71861 ( @entity5345 ) were found in eight, six and four @entity1 , respectively, and two other mutations ( @entity71862 and @entity71863 in @entity2674 ) were detected in three @entity1 each. Altogether, @entity6069 pathogenic mutations were identified in 52 out of 512 (10%) @entity1 . CONCLUSIONS: NGS substantially improved the detection rates of a wide spectrum of mutations in Polish @entity1 with @entity5344 . Although targeted screening for specific @entity5345 mutations can be offered to all Polish @entity5344 @entity1 , NGS-based testing is justified in @entity1 with @entity5344 likely related to @entity6069 who test negative for the selected @entity5345 /2 pathogenic mutations.

title: New recurrent @entity6069 mutations in Polish @entity1 with XXXX detected by next generation sequencing.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity5344 :: ('MESH:D061325', 'Disease') :: ['familial breast and/or ovarian cancers', 'familial breast and/or ovarian cancer', 'breast or ovarian cancer', 'breast and/or ovarian cancers']

answer: @entity5344 :: (MESH:D061325,Disease) :: ['familial breast/ovarian cancer']


abstract: BACKGROUND: Targeted PCR-based genetic testing for @entity5345 and @entity2674 can be performed at a lower cost than full gene testing; however, it does not detect mutations responsible for @entity5344 . In the present study, we report the utility of next generation sequencing (NGS) to identify new pathogenic variants of @entity6069 . METHODS: @entity5345 and @entity2674 exons were amplified using the Ion AmpliSeq @entity6069 Panel and sequenced on the Ion Torrent PGM sequencer in 512 @entity1 with familial and/or only early onset @entity5344 who were negative for selected @entity5345 /2 mutations. RESULTS: 146 single @entity4334 variants (SNVs) and 32 indels were identified. Of them, 14 SNVs and 17 indels were considered as pathogenic or likely pathogenic. One and 18 pathogenic mutations had been detected previously in the Polish and other populations, respectively, and 12 deleterious mutations were previously unknown. Eight mutations were recurrent; @entity71860 ( @entity5345 ), N3124I ( @entity2674 ) and @entity71861 ( @entity5345 ) were found in eight, six and four @entity1 , respectively, and two other mutations ( @entity71862 and @entity71863 in @entity2674 ) were detected in three @entity1 each. Altogether, @entity6069 pathogenic mutations were identified in 52 out of 512 (10%) @entity1 . CONCLUSIONS: NGS substantially improved the detection rates of a wide spectrum of mutations in Polish @entity1 with @entity5344 . Although targeted screening for specific @entity5345 mutations can be offered to all Polish @entity5344 @entity1 , NGS-based testing is justified in @entity1 with @entity5344 likely related to @entity6069 who test negative for the selected @entity5345 /2 pathogenic mutations.

title: New recurrent XXXX mutations in Polish @entity1 with @entity5344 detected by next generation sequencing.

answer: @entity6069 :: (672;675,Gene) :: ['BRCA1/2']


abstract: BACKGROUND: Targeted PCR-based genetic testing for @entity5345 and @entity2674 can be performed at a lower cost than full gene testing; however, it does not detect mutations responsible for @entity5344 . In the present study, we report the utility of next generation sequencing (NGS) to identify new pathogenic variants of @entity6069 . METHODS: @entity5345 and @entity2674 exons were amplified using the Ion AmpliSeq @entity6069 Panel and sequenced on the Ion Torrent PGM sequencer in 512 @entity1 with familial and/or only early onset @entity5344 who were negative for selected @entity5345 /2 mutations. RESULTS: 146 single @entity4334 variants (SNVs) and 32 indels were identified. Of them, 14 SNVs and 17 indels were considered as pathogenic or likely pathogenic. One and 18 pathogenic mutations had been detected previously in the Polish and other populations, respectively, and 12 deleterious mutations were previously unknown. Eight mutations were recurrent; @entity71860 ( @entity5345 ), N3124I ( @entity2674 ) and @entity71861 ( @entity5345 ) were found in eight, six and four @entity1 , respectively, and two other mutations ( @entity71862 and @entity71863 in @entity2674 ) were detected in three @entity1 each. Altogether, @entity6069 pathogenic mutations were identified in 52 out of 512 (10%) @entity1 . CONCLUSIONS: NGS substantially improved the detection rates of a wide spectrum of mutations in Polish @entity1 with @entity5344 . Although targeted screening for specific @entity5345 mutations can be offered to all Polish @entity5344 @entity1 , NGS-based testing is justified in @entity1 with @entity5344 likely related to @entity6069 who test negative for the selected @entity5345 /2 pathogenic mutations.

title: New recurrent @entity6069 mutations in Polish XXXX with @entity5344 detected by next generation sequencing.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: There is limited evidence to support decision making on antiplatelet therapy following transcatheter @entity886 (TAVI). Our aim was to assess the efficacy and safety of @entity117 -only (ASA) versus dual antiplatelet therapy (DAPT) following TAVI. METHODS: We performed a systematic review and pooled analysis of individual @entity1 data from 672 @entity1 comparing single versus DAPT following TAVI. Primary endpoint was defined as the composite of net adverse clinical and cerebral events (NACE) at 1   month, including all-cause mortality, @entity1187 ( @entity1187 ), @entity64 , life-threatening and major @entity548 . RESULTS: At 30   days a NACE rate of 13% was observed in the ASA-only and in 15% of the DAPT group (OR 0.83, 95% CI 0.48 to 1.43, p=0.50). A tendency towards less life-threatening and major @entity548 was observed in @entity1 treated with ASA (OR 0.56, 95% CI 0.28 to 1.11, p=0.09). Also, ASA was not associated with an increased all-cause mortality (OR 0.91, 95% CI 0.36 to 2.27, p=0.83), @entity1187 (OR 0.5, 95% CI 0.05 to 5.51, p=0.57) or @entity64 (OR 1.21; 95% CI 0.36 to 4.03, p=0.75). CONCLUSIONS: No difference in 30-day NACE rate was observed between ASA-only or DAPT following TAVI. Moreover, a trend towards less life-threatening and major @entity548 was observed in favour of ASA. Consequently the additive value of @entity1397 warrants further investigation.

title: Antiplatelet therapy following transcatheter XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1397 :: ('MESH:C055162', 'Chemical') :: ['clopidogrel']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve implantation']

answer: @entity886 :: (MESH:C563178,Disease) :: ['aortic valve implantation']


abstract: INTRODUCTION: Stress-induced @entity296 (Takotsubo) after @entity5157 stings in @entity1 who have received @entity2661 is rare. Endogenous as well as exogenous administration of @entity2661 is thought to trigger stress-induced @entity296 . CASE PRESENTATION: A 37-year-old healthy white @entity1 was stung by an unknown Hymenoptera that resulted in an anaphylactic reaction. Intravenous @entity1425 (0.9  mg) was administered at a nearby clinic; she was transferred to our emergency room. @entity1455 was diagnosed and mechanical ventilation commenced. Hemodynamic stabilization was not achieved by inotropic support and intra-aortic balloon pump insertion. Initial coronary angiography did not demonstrate any @entity301 while her left ventricular systolic function was severely @entity308 . Peripheral femoral venoarterial extracorporeal membrane oxygenation was inserted as a bridge to recovery assuming possible reversible cause of the @entity1455 . Over the following 48  hours she was extubated and gradually weaned off venoarterial extracorporeal membrane oxygenation and inotropic support. She was discharged with a near normal left ventricular ejection fraction and in 3  weeks she was asymptomatic with normal electrocardiographic and echocardiographic examinations (left ventricular ejection fraction >65  %). CONCLUSIONS: A Hymenoptera sting may be a specific cause of @entity5733 cardiac @entity308 . The presence of @entity1455 and its etiology should prompt aggressive management including extracorporeal membrane oxygenation as a bridge to cardiac functional recovery in such rare scenarios.

title: Takotsubo cardiomyopathy caused by @entity1425 -treated XXXX sting anaphylaxis: a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression']

entities_list: @entity5733 :: ('D002395', 'Chemical') :: ['catecholamine']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary obstructive lesions']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline']

entities_list: @entity2661 :: ('MESH:D002395', 'Chemical') :: ['catecholamines']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['Cardiogenic shock', 'cardiogenic shock']

answer: @entity5157 :: (7460,Species) :: ['bee']


abstract: INTRODUCTION: Stress-induced @entity296 (Takotsubo) after @entity5157 stings in @entity1 who have received @entity2661 is rare. Endogenous as well as exogenous administration of @entity2661 is thought to trigger stress-induced @entity296 . CASE PRESENTATION: A 37-year-old healthy white @entity1 was stung by an unknown Hymenoptera that resulted in an anaphylactic reaction. Intravenous @entity1425 (0.9  mg) was administered at a nearby clinic; she was transferred to our emergency room. @entity1455 was diagnosed and mechanical ventilation commenced. Hemodynamic stabilization was not achieved by inotropic support and intra-aortic balloon pump insertion. Initial coronary angiography did not demonstrate any @entity301 while her left ventricular systolic function was severely @entity308 . Peripheral femoral venoarterial extracorporeal membrane oxygenation was inserted as a bridge to recovery assuming possible reversible cause of the @entity1455 . Over the following 48  hours she was extubated and gradually weaned off venoarterial extracorporeal membrane oxygenation and inotropic support. She was discharged with a near normal left ventricular ejection fraction and in 3  weeks she was asymptomatic with normal electrocardiographic and echocardiographic examinations (left ventricular ejection fraction >65  %). CONCLUSIONS: A Hymenoptera sting may be a specific cause of @entity5733 cardiac @entity308 . The presence of @entity1455 and its etiology should prompt aggressive management including extracorporeal membrane oxygenation as a bridge to cardiac functional recovery in such rare scenarios.

title: Takotsubo cardiomyopathy caused by XXXX -treated @entity5157 sting anaphylaxis: a case report.

answer: @entity1425 :: (MESH:D004837,Chemical) :: ['epinephrine']


abstract: BACKGROUND: @entity56 , @entity5929 , and @entity56 are all forms of immunologically mediated @entity358 . Recognition that more than one of these diseases may co-exist is necessary for proper @entity1 management. OBJECTIVE: To report a case of extrinsic (cat) @entity565 , @entity5929 , @entity56 , and potentially fatal @entity565 . Immunologic mechanisms and treatment of these diseases are discussed. METHODS: The study is a case report from a university hospital setting. Serum precipitating antibodies against avian antigens were measured using gel-diffusion technique. Serum IgE levels were measured and skin testing was performed to selected antigens. RESULTS: The @entity1 had positive cutaneous reactivity to cat antigen and Aspergillus. Serology for @entity5929 and serum precipitating antibodies to finch extract were positive. Symptoms improved and @entity229 requirements decreased after removal of finches. CONCLUSION: A case of cat @entity565 , potentially fatal @entity565 , @entity5929 , and @entity56 is presented. Early recognition and treatment of @entity1200 with avoidance measures and use of @entity288 can prevent progressive @entity16 .

title: XXXX : a case report.

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['respiratory damage']

entities_list: @entity1200 :: ('MESH:D007154', 'Disease') :: ['multifactorial immunologic lung disease']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease']

entities_list: @entity5929 :: ('MESH:D001229', 'Disease') :: ['allergic bronchopulmonary aspergillosis']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['Allergic asthma', 'hypersensitivity pneumonitis']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity1200 :: (MESH:D007154,Disease) :: ['Multifactorial immunologic lung disease']


abstract: Micronutrients play a key role in many of the metabolic processes that promote survival from @entity3124 . For @entity2221 , these processes include oxidative phosphorylation, which is altered in the @entity1 with systemic @entity32 , and protection against mediators, in particular oxidants. Trace elements are essential for direct antioxidant activity as well as functioning as cofactors for a variety of antioxidant enzymes. @entity130 and immune function also depend on adequate levels of vitamins and trace elements (Table 6). Of extreme importance is the ease with which a deficiency state can develop in the critically ill because of decreased nutrient intakes and increased requirements. Daily intakes up to or exceeding many times the RDA usually are required. The enteral route is preferred, although, if not available, most of these agents can be given by the parenteral route. In that case, however, dose recommendations are less clear. Attention to micronutrients is paramount both in optimizing the nutritional management of the critically ill and in the overall management of these @entity1 . It also is essential in promoting positive outcomes and decreasing complications.

title: Micronutrients in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness']

entities_list: @entity2221 :: ('CHEBI:33229', 'Chemical') :: ['vitamins']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Wound healing']

answer: @entity3124 :: (MESH:D016638,Disease) :: ['critical illness']


abstract: A randomized prospective study was carried out to compare one-portal endoscopic @entity923 release with an open procedure. There were 47 @entity1 (mean age 52.6 years); 25 underwent an endoscopic and 22 an open release. The aim of the study was to evaluate the risks against the benefits for @entity158 , grip, key-pinch strength and ability to return to work. The distribution of age, occupation, sex, neurographic findings and operated hand was similar in both groups. We detected no serious nerve complications. One "open" @entity1 developed a @entity2805 , a second "open" @entity1 a disabling @entity6865 , one "endo" @entity1 a transient neurapraxia. The remaining @entity1 experienced complete relief of symptoms. Improvement of grip strength is significantly better after endoscopic release (P = 0.0001 at 3 months). In contrast, the key-pinch showed a similar pattern of improvement in both groups. The ability to use the operated hand as effectively as the contralateral one developed after 24 days for the endoscopic group versus 42 for the open approach (P = 0.0000). The carpal arch alteration was less important for the endoscopic group (P = 0.013), but without any correlation with the grip strength. Agee's one-portal technique only allows correct placement of a knife, not an inspection of the structures being operated upon. This is a major limitation, reducing the surgeon to a technician. Further development of this procedure demands a device that will enable a fruitful inspection of the @entity923 .

title: The value of one-portal endoscopic XXXX release: a prospective randomized study.

entities_list: @entity6865 :: ('MESH:D012019', 'Disease') :: ['reflex sympathetic dystrophy']

entities_list: @entity2805 :: ('MESH:D017439', 'Disease') :: ['hypertrophic scar']

entities_list: @entity923 :: ('MESH:D002349', 'Disease') :: ['carpal tunnel']

answer: @entity923 :: (MESH:D002349,Disease) :: ['carpal tunnel']


abstract: A 68-year-old @entity1 had been complained of @entity2133 since she was 30 years old. Further symptoms of @entity2011 , polyposia and @entity22 had been developed since she was 35 years old. The biopsy material from a minor salivary gland demonstrated the infiltration of lymphocytes into mesenchyme which was compatible with @entity244 . She admitted to our hospital because of @entity925 in bilateral gastrocnemius and petechiae in both lower extremities in addition to the complaints described above. Complete blood cell counts on admission revealed hemoglobin 9.7 g/dl, platelet count 12.5 x 10(4)/microliters, and white blood cell count 3,300/microliters. Marked @entity2011 , polyposia (more than 5,000 ml/day, respectively) and low urine gravity (1.005) were observed, although the serum @entity1011 level showed normal value. Serologic examination showed that the elevation of total serum protein concentration (9.5 g/dl) with marked elevation of serum IgG level (6,190 mg/dl). Her immunoglobulins contained cryoglobulin (cryocrit 20%), and immunoelectrophoresis demonstrated the existence of IgG-kappa monoclonal protein. A positive anti-nuclear antibody at 1:320 dilution, a positive rheumatoid factor and a positive antibody to @entity6540 (Ro) were also observed. The serial studies of blood gas analysis could not demonstrated the presence of @entity520 . Together with the result of elevated plasma antidiuretic hormone level and results of @entity1951 test, Fishberg's concentrating test and the tests of the overload of @entity8777 or @entity3157 , she was diagnosed @entity244 with both @entity2010 and @entity8 . She was initially medicated with @entity617 (40 mg/day, orally), then she was given six courses of intravenous @entity786 (750 mg/body/month).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of @entity244 complicated with cryoglobulinemia, nephrogenic diabetes insipidus, and XXXX ].

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['subclinical renal tubular acidosis']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia']

entities_list: @entity1951 :: ('MESH:D014667', 'Chemical') :: ['vasopressin']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis']

entities_list: @entity2010 :: ('MESH:D003919', 'Disease') :: ['diabetes insipidus']

entities_list: @entity244 :: ('MESH:D014899', 'Disease') :: ["Sj  gren's syndrome"]

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']

answer: @entity8 :: (MESH:D007674,Disease) :: ['renal tubular acidosis']


abstract: A 68-year-old @entity1 had been complained of @entity2133 since she was 30 years old. Further symptoms of @entity2011 , polyposia and @entity22 had been developed since she was 35 years old. The biopsy material from a minor salivary gland demonstrated the infiltration of lymphocytes into mesenchyme which was compatible with @entity244 . She admitted to our hospital because of @entity925 in bilateral gastrocnemius and petechiae in both lower extremities in addition to the complaints described above. Complete blood cell counts on admission revealed hemoglobin 9.7 g/dl, platelet count 12.5 x 10(4)/microliters, and white blood cell count 3,300/microliters. Marked @entity2011 , polyposia (more than 5,000 ml/day, respectively) and low urine gravity (1.005) were observed, although the serum @entity1011 level showed normal value. Serologic examination showed that the elevation of total serum protein concentration (9.5 g/dl) with marked elevation of serum IgG level (6,190 mg/dl). Her immunoglobulins contained cryoglobulin (cryocrit 20%), and immunoelectrophoresis demonstrated the existence of IgG-kappa monoclonal protein. A positive anti-nuclear antibody at 1:320 dilution, a positive rheumatoid factor and a positive antibody to @entity6540 (Ro) were also observed. The serial studies of blood gas analysis could not demonstrated the presence of @entity520 . Together with the result of elevated plasma antidiuretic hormone level and results of @entity1951 test, Fishberg's concentrating test and the tests of the overload of @entity8777 or @entity3157 , she was diagnosed @entity244 with both @entity2010 and @entity8 . She was initially medicated with @entity617 (40 mg/day, orally), then she was given six courses of intravenous @entity786 (750 mg/body/month).(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of XXXX complicated with cryoglobulinemia, nephrogenic diabetes insipidus, and @entity8 ].

answer: @entity244 :: (MESH:D014899,Disease) :: ['Sj  gren's syndrome']


abstract: @entity1884 ( @entity1884 ) usually presents in association with @entity2702 ( @entity2702 ). In addition, the incidence of @entity1211 tends to be increased in these @entity1 . A 74-year-old female with @entity1884 presented with @entity848 and @entity519 . Contrast-enhanced multislice computed tomography (MSCT) revealed two left @entity2702 and one in the right upper lobe. Both left @entity2702 were treated with embolotherapy. Follow-up MSCT revealed an @entity1151 in the right pulmonary branches. @entity1150 was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of @entity1031 . Finally, embolotherapy was performed. This case illustrates the chronic adaptation to @entity519 and adds further evidence to the relative safety of anticoagulation treatment in these @entity1 .

title: Huge XXXX and Anticoagulation Treatment in a @entity1 with @entity1884 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1884 :: ('MESH:D013683', 'Disease') :: ['HHT', 'Hereditary hemorrhagic telangiectasia']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['incidental pulmonary embolism']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['Deep venous thrombosis']

entities_list: @entity2702 :: ('MESH:C562404', 'Disease') :: ['pulmonary arteriovenous malformations', 'PAVMs']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxemia']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous thromboembolism']

entities_list: @entity848 :: ('MESH:D003490', 'Disease') :: ['cyanosis']

answer: @entity1211 :: (MESH:D054556,Disease) :: ['Pulmonary Arteriovenous Malformation, Venous Thromboembolism']


abstract: @entity1884 ( @entity1884 ) usually presents in association with @entity2702 ( @entity2702 ). In addition, the incidence of @entity1211 tends to be increased in these @entity1 . A 74-year-old female with @entity1884 presented with @entity848 and @entity519 . Contrast-enhanced multislice computed tomography (MSCT) revealed two left @entity2702 and one in the right upper lobe. Both left @entity2702 were treated with embolotherapy. Follow-up MSCT revealed an @entity1151 in the right pulmonary branches. @entity1150 was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of @entity1031 . Finally, embolotherapy was performed. This case illustrates the chronic adaptation to @entity519 and adds further evidence to the relative safety of anticoagulation treatment in these @entity1 .

title: Huge @entity1211 and Anticoagulation Treatment in a @entity1 with XXXX .

answer: @entity1884 :: (MESH:D013683,Disease) :: ['Hereditary Hemorrhagic Telangiectasia']


abstract: @entity1884 ( @entity1884 ) usually presents in association with @entity2702 ( @entity2702 ). In addition, the incidence of @entity1211 tends to be increased in these @entity1 . A 74-year-old female with @entity1884 presented with @entity848 and @entity519 . Contrast-enhanced multislice computed tomography (MSCT) revealed two left @entity2702 and one in the right upper lobe. Both left @entity2702 were treated with embolotherapy. Follow-up MSCT revealed an @entity1151 in the right pulmonary branches. @entity1150 was confirmed and anticoagulation was initiated. Follow-up MSCT revealed the resolution of @entity1031 . Finally, embolotherapy was performed. This case illustrates the chronic adaptation to @entity519 and adds further evidence to the relative safety of anticoagulation treatment in these @entity1 .

title: Huge @entity1211 and Anticoagulation Treatment in a XXXX with @entity1884 .

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: Natural killer (NK) activity was assayed in fresh peripheral blood mononuclear cells (PBMs) from @entity5 @entity1 receiving @entity2391 ser. @entity1 received a single intravenous injection of @entity2391 ser (90 x 10(6) IU m-2) on alternate days for 2 weeks, followed by a higher dose (180 x 10(6) IU m-2) on the same schedule. PBM NK lysis of K562 target cells was significantly increased in PBMs sampled 24 h after the initial injection (P < 0.05). At the end of the first 2 weeks of the protocol, NK cytotoxic activity of PBMs had fallen below the original baseline levels; the higher IFN dose subsequently given was without effect. However, significant increases in the proportion of @entity4071 + cells were seen following each injection. A positive correlation was also seen between the increased lytic activity of @entity4071 + NK cells and the proportion of @entity3053 + NK cells, but not the proportion of @entity2940 + NK cells. In vitro IFN-treatment of these in vivo-treated PBMs resulted in a further increase in NK activity. Pre-exposure in vivo to @entity2391 ser seems to prime the PBMs to respond to in vitro stimulation by @entity379 , which otherwise had no effect. Phenotypic analysis of PBMs after in vitro exposure to @entity2391 ser showed that the levels of @entity4071 +, @entity3053 + and @entity2940 + cells did not change. All the NK activity responding to @entity2391 ser was found in the @entity4071 + enriched population of PBM, suggesting that it is unlikely that in vivo redistribution of @entity4071 + subsets representative of NK cells has occurred in the peripheral blood.

title: In vivo priming effects of interferon-beta ser on NK activity of peripheral blood mononuclear cells in XXXX @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2391 :: ('3456', 'Gene') :: ['interferon (IFN)-beta', 'IFN-beta']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: Natural killer (NK) activity was assayed in fresh peripheral blood mononuclear cells (PBMs) from @entity5 @entity1 receiving @entity2391 ser. @entity1 received a single intravenous injection of @entity2391 ser (90 x 10(6) IU m-2) on alternate days for 2 weeks, followed by a higher dose (180 x 10(6) IU m-2) on the same schedule. PBM NK lysis of K562 target cells was significantly increased in PBMs sampled 24 h after the initial injection (P < 0.05). At the end of the first 2 weeks of the protocol, NK cytotoxic activity of PBMs had fallen below the original baseline levels; the higher IFN dose subsequently given was without effect. However, significant increases in the proportion of @entity4071 + cells were seen following each injection. A positive correlation was also seen between the increased lytic activity of @entity4071 + NK cells and the proportion of @entity3053 + NK cells, but not the proportion of @entity2940 + NK cells. In vitro IFN-treatment of these in vivo-treated PBMs resulted in a further increase in NK activity. Pre-exposure in vivo to @entity2391 ser seems to prime the PBMs to respond to in vitro stimulation by @entity379 , which otherwise had no effect. Phenotypic analysis of PBMs after in vitro exposure to @entity2391 ser showed that the levels of @entity4071 +, @entity3053 + and @entity2940 + cells did not change. All the NK activity responding to @entity2391 ser was found in the @entity4071 + enriched population of PBM, suggesting that it is unlikely that in vivo redistribution of @entity4071 + subsets representative of NK cells has occurred in the peripheral blood.

title: In vivo priming effects of interferon-beta ser on NK activity of peripheral blood mononuclear cells in @entity5 XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity263 is a leading cause of @entity5 death amongst males. The main clinical dilemma in treating @entity263 is the high number of indolent cases that confer a significant risk of overtreatment. In this study, we have performed gene expression profiling of @entity5 tissue specimens from 36 @entity1 with @entity263 to identify transcripts that delineate @entity146 and indolent @entity5 . Key genes were validated using previously published data and by tissue microarray analysis. Two molecular subgroups were identified with a significant overrepresentation of @entity5 from @entity1 with biochemical recurrence in one of the groups. We successfully validated key transcripts association with recurrence using two publically available datasets totaling 669 @entity1 . Twelve genes were found to be independent predictors of recurrence in multivariate logistical regression analysis. @entity18181 gene expression was consistently up regulated in @entity1 with recurrence in all three datasets. Using an independent cohort of 536 @entity263 @entity1 we showed @entity18181 expression to be an independent predictor of recurrence after prostatectomy (HR   =   1.35; p   =   0.009). We identified @entity18181 to be associated with disease recurrence. Prospective studies are needed in order to assess the clinical usefulness of the identified key markers in this study.

title: Expression profiling of XXXX tissue delineates genes associated with recurrence after prostatectomy.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'Prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: BACKGROUND: @entity28691 (193 nm) excimer laser photorefractive keratectomy for @entity1714 is under evaluation by the United States Food and Drug Administration. METHODS: We report a consecutive prospective series of 100 @entity1 (one eye per @entity1 ) treated as part of the Phase IIB FDA-approved protocol, with 80 @entity1 followed for 1 year. @entity1 ' ages ranged from 21 to 62 years (mean, 35 years). The Summit Technology, Inc ExciMed UV200LA with a 4.5-mm diameter ablation was used. RESULTS: Baseline spherical equivalent refraction ranged from -2.00 to -6.90 diopters (D) (mean -4.60 D). Ninety-five percent of eyes reepithelialized by 72 hours. At 1 year, the difference between attempted and achieved correction was +/- 0.50 D for 42 eyes (53%) and +/- 1.00 D for 60 eyes (75%). During the first 6 months, there was a trend toward overcorrection and the majority of eyes showed some loss of initial refractive correction; 10 eyes (14%) changed by 1.00 D or more between 6 and 12 months. An uncorrected visual acuity of 20/25 or better was achieved by 50 eyes (63%) and 20/40 or better by 61 eyes (77%). Of the 10 eyes (12%) that lost two or more Snellen lines of spectacle-corrected or glare visual acuity, two had visual acuity of worse than 20/25. Central subepithelial corneal haze was absent to mild in 77 (96%) eyes at 12 months. CONCLUSIONS: Excimer laser photorefractive keratectomy as performed in this study was generally effective and safe in reducing simple spherical @entity1714 . Further studies of the effect of a larger diameter ablation zone, smoother transitional corneal contours, and the effect of postoperative topical corticosteroids may lead to further improvements in outcome.

title: Photorefractive keratectomy for XXXX using a 4.5-millimeter ablation zone.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity28691 :: ('MESH:C047730', 'Chemical') :: ['Argon fluoride']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['myopia']


abstract: INTRODUCTION: Great strides in pediatric @entity5 treatment are allowing hundreds of thousands of @entity1 to survive into adulthood. However, these treatments can be responsible for long-term medical and dental complications. The treatments may alter the @entity1 ' dental health and require modifications to standard orthodontic care. The aim of this study was to examine knowledge and clinical experience regarding orthodontic management of childhood @entity5 survivors. METHODS: A 12-question online survey consisting of 3 sections was sent to 2500 randomly selected members of the American Association of Orthodontists and all 2300 members of the Southern Association of Orthodontists. The first section consisted of questions about the respondents' practice characteristics, the second questioned how many survivor @entity1 the respondent had treated, and the third included questions about specific (anonymous) @entity1 experiences and treatment modifications. RESULTS AND CONCLUSIONS: There were 381 responses. The data from this study suggest a tendency for more experienced practitioners to have treated survivors of childhood @entity5 . Orthodontic education regarding the treatment of these @entity1 is limited. Although most orthodontists reported having treated such @entity1 , few had treated more than 10. There is a need for more @entity5 treatment and for guidelines for the orthodontic treatment of these @entity1 .

title: Experience and expertise regarding orthodontic management of childhood and adolescent XXXX survivors.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['information regarding dental complications of pediatric cancer', 'cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND: @entity10996 ( @entity10996 ) has several known risk factors. The association between @entity3465 and @entity10996 and the timeline of presentation are poorly defined. Our aim was to evaluate the associations between @entity10996 and @entity3465 . METHODS: We performed a retrospective cohort study of 1,074,236 @entity1 born between June 2001 and April 2012 in the US Military Health System. @entity10996 cases and gestational ages (GA) were identified using billing codes. Additional risk factors for @entity10996 were controlled for in a multivariable logistic regression model. RESULTS: The incidence of @entity10996 was 2.99 per 1,000 in preterm @entity1 and 2.25 per 1,000 in full term (relative risk (RR) = 1.33, 95% confidence interval (CI) 1.16-1.54). The adjusted odds ratio for @entity3465 was 1.26 (95% CI 1.08-1.46). The median (interquartile range (IQR)) chronological age at presentation was 40 d (30-56) in preterm @entity1 vs. 33 d (26-45) in full term (P < 0.001). Median postmenstrual age at presentation was 42   wk in preterm @entity1 (40-42) vs. 45   wk (44-46) in full term (P < 0.001). CONCLUSION: Prematurity is associated with @entity10996 . Premature @entity1 develop @entity10996 at a later chronological age, but earlier postmenstrual age, than term @entity1 . Providers should have an increased concern for @entity10996 development in premature @entity1 .

title: Association of XXXX with the development of infantile hypertrophic pyloric stenosis.

entities_list: @entity10996 :: ('MESH:C566730', 'Disease') :: ['IHPS', 'Infantile hypertrophic pyloric stenosis']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'infants']

entities_list: @entity3465 :: ('MESH:C536271', 'Disease') :: ['prematurity']

answer: @entity3465 :: (MESH:C536271,Disease) :: ['prematurity']


abstract: OBJECTIVE: Paediatric severe @entity131 ( @entity131 ) is associated with significant @entity130 affective and behavioural problems. Few studies have examined the prevalence and characteristics of affective lability after paediatric @entity131 . METHODS: Ninety-seven @entity1 with severe @entity131 were evaluated 1 year @entity130 for the presence of affective lability using the @entity1 's Affective Lability Scale (CALS). Demographic, clinical and @entity75 characteristics were also assessed. RESULTS: Affective lability significantly increased after injury. Eighty-six @entity1 had a pre-injury CALS score of 1 SD or less from the group pre-injury mean (M   =   8.11, SD   =   9.31), of which 35 and 15 @entity1 had a 1 SD and 2 SD increase in their CALS score from pre- to @entity130 , respectively. A variety of affective shifts manifested @entity130 including @entity148 , silliness, dysphoria and @entity146 . The most severe symptoms were @entity146 and unpredictable temper outbursts. Risk factors for affective lability included elevated pre-injury affective lability and psychosocial adversity as well as greater damage to the orbitofrontal cortex. Post-injury affective lability was most frequently associated with a @entity130 diagnosis of @entity71 . CONCLUSIONS: Affective lability is common after paediatric @entity131 and frequently manifests as @entity146 and unpredictable outbursts. Early intervention is needed to improve @entity146 outcomes.

title: Prevalence and predictors of affective lability after paediatric XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['irritability', 'psychiatric']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain lesion']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['attention-deficit hyperactivity disorder']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['post-injury']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: @entity842 (NO) gas is known as both a vasodilator and a toxin. It can react with @entity26 to form compounds more @entity137 than itself, such as @entity7459 ( @entity6836 ). The reactions are time dependent; thus, infusing NO into breathing circuits as close to ventilated subjects as possible may help minimize @entity137 byproduct exposure. Unfortunately, flow rates commonly used with mechanical ventilation favor laminar gas flow (streaming) within the breathing circuits. Streaming could delay mixing of NO with other inhaled gases. This mixing delay may interfere with accurate monitoring and/or delivery of NO. We tested the hypothesis that streaming of NO infused by constant flow into the inspiratory limb of a constant-flow mechanical ventilation system can lead to NO concentration delivery estimate errors. We then compared the @entity6836 concentrations at the ventilator Y-piece with three different NO mixing methods: blending the gases before they reach the breathing circuit inspiratory limb, infusing NO directly into the breathing circuit inspiratory limb far enough from the Y-piece to ensure thorough mixing, and infusing NO directly into the breathing circuit inspiratory limb immediately before the gases reach an in-line mixing device placed close to the Y-piece. Our results indicate that streaming can lead to NO concentration delivery estimate errors and that these errors can be characterized by measuring NO concentration variations across the inspiratory tubing's luminal diameter. @entity6836 concentration measured at the ventilator Y-piece were dependent on NO concentrations (p < 0.0001), NO delivery methods (p < 0.0001), and interactions between NO concentrations and NO delivery methods (p < 0.0001). We conclude that gas streaming and @entity137 byproduct exposure should be considered together when choosing an NO delivery method.

title: XXXX administration using constant-flow ventilation.

entities_list: @entity7459 :: ('MESH:D009585', 'Chemical') :: ['nitrogen dioxide']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['Nitric oxide']

answer: @entity842 :: (MESH:D009569,Chemical) :: ['Nitric oxide']


abstract: OBJECTIVE: To explore validity of an assessment tool under development-the Emotional Inferencing from Stories Test (EIST). This measure is being designed to assess the ability of @entity1 with @entity131 ( @entity131 ) to make inferences about the emotional state of others solely from contextual cues. METHODS AND PROCEDURES: Study 1: 25 stories were presented to 40 healthy young adults. From this data, two versions of the EIST (EIST-1; EIST-2) were created. Study 2: Each version was administered to a group of @entity1 with moderate-to-severe @entity131 -EIST 1 group: 77 @entity1 ; EIST-2 group: 126 @entity1 . @entity1 also completed a facial affect recognition (DANVA2-AF) test. @entity1 with @entity73 returned 2 weeks later and were re-administered both tests. MAIN OUTCOMES: @entity1 with @entity131 scored significantly lower than the healthy group mean for EIST-1, F(1,114)   =   68.49, p   <   0.001, and EIST-2, F(1,163)   =   177.39, p   <   0.001. EIST scores in the EIST-2 group were significantly lower than the EIST-1 group, t   =   4.47, p   <   0.001. DANVA2-AF scores significantly correlated with EIST scores, EIST-1: r   =   0.50, p   <   0.001; EIST-2: r   =   0.31, p   <   0.001. Test-re-test reliability scores for the EIST were adequate. CONCLUSIONS: Both versions of the EIST were found to be sensitive to @entity51 . After further development, the EIST may provide clinicians valuable information for intervention planning.

title: Exploration of a new tool for assessing emotional inferencing after XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'people']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['facial affect recognition impairment']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['deficits in emotional inferencing']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: UNASSIGNED: 'Off-the-shelf' tissue-engineered skin alternatives for epidermal and dermal skin layers are available; however, no such alternative for the subdermal fat layer exists. Without this well-vascularized layer, skin graft take is variable and grafts may have reduced mobility, @entity1159 and contour defects. In this study a novel adipose-derived acellular matrix (Adipogel) was investigated for its properties to generate subdermal fat in a @entity35 model. In a dorsal @entity1514 site, a 1   *   1   cm Adipogel implant was inserted within a subdermal fat @entity655 . In a dorsal lumbar site, an Adipogel implant was inserted in a subfascial pocket. Contralateral control defects remained empty. At 8   weeks wound/implant sites were evaluated histologically, immunohistochemically and morphometrically. Identifiable @entity1514 Adipogel implants lost volume in vivo over 8   weeks. @entity2295 and adipogenesis were evident within implants and adipocyte percentage volume was 33.07        6.55% (mean        SEM). A comparison of entire cross-sections of @entity1514 wounds demonstrated a significant @entity130 (37.19        4.48%, mean        SEM) compared to control (16.53        4.60%; p   =   0.0092), indicating that some Adipogel had been completely converted to normal fat. At the lumbar site, Adipogel also lost volume, appearing flattened, although fat generation and angiogenesis occurred. At both sites macrophage infiltration was mild, whilst many infiltrating cells were @entity13963 -positive mesenchymal cells. Adipogel is adipogenic and angiogenic and is a promising candidate for subcutaneous fat regeneration; it has the potential to be a valuable adjunct to wound-healing therapy and reconstructive surgery practice. Copyright    2015 John Wiley _ Sons, Ltd.

title: An adipogenic gel for surgical reconstruction of the subcutaneous fat layer in a XXXX model.

entities_list: @entity2295 :: ('MESH:D015861', 'Disease') :: ['Neovascularization']

entities_list: @entity1159 :: ('MESH:D003286', 'Disease') :: ['contracture']

entities_list: @entity655 :: ('MESH:C535504', 'Disease') :: ['layer defect']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['increase in total wound fat in Adipogel-implanted wounds']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: We examine the origins of surgical therapy, radiotherapy, and chemotherapy as they were applied to @entity2 in the mid-portion of this century. Surgical therapy for @entity2 started in the 1930s with pneumonectomies. The prognostic significance of nodal @entity3 was soon recognized, and surgical staging procedures became an important part of @entity1 workup. Radical radiotherapy for potential cure of @entity2 began in the 1950s with megavoltage linear accelerators. The first application of chemotherapy for @entity2 was the use of @entity1568 mustards in the 1940s. Single modality surgical therapy has become the treatment of choice for Stages I and II @entity1149 , but 50% of clinical Stage I @entity1 die of recurrent disease, and 70% of those recur outside the chest. Biologic markers may identify high risk subgroups of Stage I and II @entity1 who may benefit from adjuvant chemo- or radiotherapy. Within the last decade, several single and multi-institutional Phase II trials and two single institution Phase III trials have reported improved survival in Stage IIIA @entity1 treated with @entity900 -based neoadjuvant chemotherapy prior to surgical resection. These trials have reported high response and resectability rates, but at a substantial @entity137 . A new standard of care for Stage IIIA disease has not been conclusively established.

title: An historical perspective of multi-modality treatment for resectable XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']


abstract: UNASSIGNED: @entity1832 ( @entity1832 ) is a @entity179 caused by abnormal accumulation of @entity1832 , which are intracellular deposits composed primarily of aggregated @entity8095 (aSyn). Although aSyn has been strongly implicated to induce @entity2359 , overexpression of wild-type aSyn is shown to be insufficient to trigger formation of protein aggregates by itself. Therefore, investigating the possible mechanism underlying aSyn aggregation is essential to understand the pathogenesis of @entity1832 . Previous studies have demonstrated that amyloid b (Ab), the primary cause of @entity195 ( @entity195 ), may promote the formation of aSyn inclusion bodies. However, it remains unclear how Ab contributes to the deposition and @entity2359 of aSyn. In the present study, we investigated the cytotoxic effects of Ab in aSyn-overexpressed neuronal cells. Our results showed that Ab inhibits autophagy and enhances aSyn aggregation in aSyn-overexpressed cells. Moreover, Ab also reduced @entity4093 ( @entity4093 ) and its downstream signaling, resulting in increased intracellular ROS accumulation and @entity2383 . Our in vitro and in vivo studies support that Ab-inhibition of @entity8582 -activated protein kinase (AMPK) signaling is involved in the @entity2359 effects of aSyn. Taken together, our findings suggest that Ab plays a synergistic role in aSyn aggregation and @entity137 , which may provide a novel understanding for exploring the underlying molecular mechanism of @entity1832 .

title: Amyloid-b suppresses @entity8582 -activated protein kinase (AMPK) signaling and contributes to @entity8095 -induced XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity1832 :: ('MESH:D020961', 'Disease') :: ['Lewy bodies', 'DLB', 'Dementia with Lewy bodies']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative disorder']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity', 'neurotoxic']

entities_list: @entity2383 :: ('MESH:D028361', 'Disease') :: ['mitochondrial dysfunction']

answer: @entity137 :: (MESH:D064420,Disease) :: ['cytotoxicity']


abstract: UNASSIGNED: @entity1832 ( @entity1832 ) is a @entity179 caused by abnormal accumulation of @entity1832 , which are intracellular deposits composed primarily of aggregated @entity8095 (aSyn). Although aSyn has been strongly implicated to induce @entity2359 , overexpression of wild-type aSyn is shown to be insufficient to trigger formation of protein aggregates by itself. Therefore, investigating the possible mechanism underlying aSyn aggregation is essential to understand the pathogenesis of @entity1832 . Previous studies have demonstrated that amyloid b (Ab), the primary cause of @entity195 ( @entity195 ), may promote the formation of aSyn inclusion bodies. However, it remains unclear how Ab contributes to the deposition and @entity2359 of aSyn. In the present study, we investigated the cytotoxic effects of Ab in aSyn-overexpressed neuronal cells. Our results showed that Ab inhibits autophagy and enhances aSyn aggregation in aSyn-overexpressed cells. Moreover, Ab also reduced @entity4093 ( @entity4093 ) and its downstream signaling, resulting in increased intracellular ROS accumulation and @entity2383 . Our in vitro and in vivo studies support that Ab-inhibition of @entity8582 -activated protein kinase (AMPK) signaling is involved in the @entity2359 effects of aSyn. Taken together, our findings suggest that Ab plays a synergistic role in aSyn aggregation and @entity137 , which may provide a novel understanding for exploring the underlying molecular mechanism of @entity1832 .

title: Amyloid-b suppresses @entity8582 -activated protein kinase (AMPK) signaling and contributes to XXXX -induced @entity137 .

answer: @entity8095 :: (6622,Gene) :: ['a-synuclein']


abstract: UNASSIGNED: @entity1832 ( @entity1832 ) is a @entity179 caused by abnormal accumulation of @entity1832 , which are intracellular deposits composed primarily of aggregated @entity8095 (aSyn). Although aSyn has been strongly implicated to induce @entity2359 , overexpression of wild-type aSyn is shown to be insufficient to trigger formation of protein aggregates by itself. Therefore, investigating the possible mechanism underlying aSyn aggregation is essential to understand the pathogenesis of @entity1832 . Previous studies have demonstrated that amyloid b (Ab), the primary cause of @entity195 ( @entity195 ), may promote the formation of aSyn inclusion bodies. However, it remains unclear how Ab contributes to the deposition and @entity2359 of aSyn. In the present study, we investigated the cytotoxic effects of Ab in aSyn-overexpressed neuronal cells. Our results showed that Ab inhibits autophagy and enhances aSyn aggregation in aSyn-overexpressed cells. Moreover, Ab also reduced @entity4093 ( @entity4093 ) and its downstream signaling, resulting in increased intracellular ROS accumulation and @entity2383 . Our in vitro and in vivo studies support that Ab-inhibition of @entity8582 -activated protein kinase (AMPK) signaling is involved in the @entity2359 effects of aSyn. Taken together, our findings suggest that Ab plays a synergistic role in aSyn aggregation and @entity137 , which may provide a novel understanding for exploring the underlying molecular mechanism of @entity1832 .

title: Amyloid-b suppresses XXXX -activated protein kinase (AMPK) signaling and contributes to @entity8095 -induced @entity137 .

answer: @entity8582 :: (D000667,Chemical) :: ['AMP']


abstract: UNASSIGNED: While it has recently been shown that @entity7855 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity7855 neuroprotection. In addition, it is not known whether @entity7855 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity18 ( @entity5579 )-induced @entity17 model, the effects and mechanisms of time-dependent treatment with @entity7855 (beginning 15days after @entity179 and continuing for 15days, or @entity1021 concomitantly with @entity179 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity17 induced by @entity5579 in rodents has been widely used as a model of @entity15 ( @entity15 ). In the present study, five male C57BL/6 @entity19 aged 7-10weeks were used per group. For four weeks, the groups received either @entity18 ( @entity5579 ) 0.2% mixed in feed or @entity5579 combined with the administration of @entity7855 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity1021 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity5579 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity5579 0.3%. @entity5579 induced an increase in the expression of @entity635 and a decrease in @entity8929 , @entity13766 , @entity10927 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity1235 , @entity8929 , and @entity13766 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity10927 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity1021 after the installation of the degenerative process. Therefore, the present study shows that @entity7855 modulates inflammation, with the involvement of @entity1235 , @entity8929 , and @entity13766 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity7855 and contribute to the control of @entity179 such as @entity15 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity8929 / @entity13766 and @entity1235 regulation in a @entity18 -induced XXXX model.

entities_list: @entity17 :: ('MESH:D003711', 'Disease') :: ['demyelination']

entities_list: @entity18 :: ('MESH:D003471', 'Chemical') :: ['cuprizone']

entities_list: @entity7855 :: ('MESH:C101426', 'Chemical') :: ['sildenafil']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration', 'neurodegenerative diseases']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']

answer: @entity17 :: (MESH:D003711,Disease) :: ['demyelination']


abstract: UNASSIGNED: While it has recently been shown that @entity7855 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity7855 neuroprotection. In addition, it is not known whether @entity7855 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity18 ( @entity5579 )-induced @entity17 model, the effects and mechanisms of time-dependent treatment with @entity7855 (beginning 15days after @entity179 and continuing for 15days, or @entity1021 concomitantly with @entity179 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity17 induced by @entity5579 in rodents has been widely used as a model of @entity15 ( @entity15 ). In the present study, five male C57BL/6 @entity19 aged 7-10weeks were used per group. For four weeks, the groups received either @entity18 ( @entity5579 ) 0.2% mixed in feed or @entity5579 combined with the administration of @entity7855 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity1021 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity5579 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity5579 0.3%. @entity5579 induced an increase in the expression of @entity635 and a decrease in @entity8929 , @entity13766 , @entity10927 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity1235 , @entity8929 , and @entity13766 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity10927 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity1021 after the installation of the degenerative process. Therefore, the present study shows that @entity7855 modulates inflammation, with the involvement of @entity1235 , @entity8929 , and @entity13766 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity7855 and contribute to the control of @entity179 such as @entity15 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity8929 / @entity13766 and @entity1235 regulation in a XXXX -induced @entity17 model.

answer: @entity18 :: (MESH:D003471,Chemical) :: ['cuprizone']


abstract: UNASSIGNED: While it has recently been shown that @entity7855 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity7855 neuroprotection. In addition, it is not known whether @entity7855 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity18 ( @entity5579 )-induced @entity17 model, the effects and mechanisms of time-dependent treatment with @entity7855 (beginning 15days after @entity179 and continuing for 15days, or @entity1021 concomitantly with @entity179 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity17 induced by @entity5579 in rodents has been widely used as a model of @entity15 ( @entity15 ). In the present study, five male C57BL/6 @entity19 aged 7-10weeks were used per group. For four weeks, the groups received either @entity18 ( @entity5579 ) 0.2% mixed in feed or @entity5579 combined with the administration of @entity7855 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity1021 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity5579 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity5579 0.3%. @entity5579 induced an increase in the expression of @entity635 and a decrease in @entity8929 , @entity13766 , @entity10927 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity1235 , @entity8929 , and @entity13766 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity10927 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity1021 after the installation of the degenerative process. Therefore, the present study shows that @entity7855 modulates inflammation, with the involvement of @entity1235 , @entity8929 , and @entity13766 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity7855 and contribute to the control of @entity179 such as @entity15 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity8929 / @entity13766 and XXXX regulation in a @entity18 -induced @entity17 model.

answer: @entity1235 :: (17395(Tax:10090),Gene) :: ['MMP-9']


abstract: UNASSIGNED: While it has recently been shown that @entity7855 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity7855 neuroprotection. In addition, it is not known whether @entity7855 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity18 ( @entity5579 )-induced @entity17 model, the effects and mechanisms of time-dependent treatment with @entity7855 (beginning 15days after @entity179 and continuing for 15days, or @entity1021 concomitantly with @entity179 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity17 induced by @entity5579 in rodents has been widely used as a model of @entity15 ( @entity15 ). In the present study, five male C57BL/6 @entity19 aged 7-10weeks were used per group. For four weeks, the groups received either @entity18 ( @entity5579 ) 0.2% mixed in feed or @entity5579 combined with the administration of @entity7855 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity1021 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity5579 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity5579 0.3%. @entity5579 induced an increase in the expression of @entity635 and a decrease in @entity8929 , @entity13766 , @entity10927 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity1235 , @entity8929 , and @entity13766 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity10927 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity1021 after the installation of the degenerative process. Therefore, the present study shows that @entity7855 modulates inflammation, with the involvement of @entity1235 , @entity8929 , and @entity13766 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity7855 and contribute to the control of @entity179 such as @entity15 .

title: Phosphodiesterase-5 inhibition promotes remyelination by @entity8929 / XXXX and @entity1235 regulation in a @entity18 -induced @entity17 model.

answer: @entity13766 :: (12772(Tax:10090),Gene) :: ['CCR-2']


abstract: UNASSIGNED: While it has recently been shown that @entity7855 (Viagra  ) has a protective effect on myelination/remyelination, the mechanism of this protection is still unknown. In general, cytokines, chemokines and metalloproteinases have a pro-inflammatory action, but can also exert a role in modulating glial cell activation, contributing to the balance of cell response. Investigating these molecules can contribute to clarifying the mechanisms of @entity7855 neuroprotection. In addition, it is not known whether @entity7855 is able to restore an already installed neurodegenerative process or if the treatment period is critical for its action. The aim of the present study was to evaluate, in a @entity18 ( @entity5579 )-induced @entity17 model, the effects and mechanisms of time-dependent treatment with @entity7855 (beginning 15days after @entity179 and continuing for 15days, or @entity1021 concomitantly with @entity179 and continuing for 30days) on neuroinflammation and remyelination. Neuroinflammation and @entity17 induced by @entity5579 in rodents has been widely used as a model of @entity15 ( @entity15 ). In the present study, five male C57BL/6 @entity19 aged 7-10weeks were used per group. For four weeks, the groups received either @entity18 ( @entity5579 ) 0.2% mixed in feed or @entity5579 combined with the administration of @entity7855 (Viagra  , Pfizer, 25mg/kg) orally in drinking water, @entity1021 concurrently with (sild-T0) or 15days (sild-T15) after the start of @entity5579 treatment. Control animals received pure food and water. The cerebella were dissected and processed for immunohistochemistry, immunofluorescence (frozen), Western blotting, Luxol fast blue staining and transmission electron microscopy. Magnetic resonance was performed for live animals, after the same treatment, using @entity5579 0.3%. @entity5579 induced an increase in the expression of @entity635 and a decrease in @entity8929 , @entity13766 , @entity10927 and GST-pi, as well as promoting damage in the structure and ultra-structure of the myelin sheath. Interestingly, the administering of sild-T0 promoted a further increase of @entity1235 , @entity8929 , and @entity13766 , possibly contributing to changes in the microglia phenotype, which becomes more phagocytic, cleaning myelin debris. It was also observed that, after sild-T0 treatment, the expression of GST-pi and @entity10927 increased and the myelin structure was improved. However, sild-T15 was not efficient in all aspects, probably due to the short treatment period and to @entity1021 after the installation of the degenerative process. Therefore, the present study shows that @entity7855 modulates inflammation, with the involvement of @entity1235 , @entity8929 , and @entity13766 , and also contributes to myelin repair. These protective effects were dependent on the therapeutic strategy used. This clarification can strengthen research proposals into the mechanism of action of @entity7855 and contribute to the control of @entity179 such as @entity15 .

title: Phosphodiesterase-5 inhibition promotes remyelination by XXXX / @entity13766 and @entity1235 regulation in a @entity18 -induced @entity17 model.

answer: @entity8929 :: (17224(Tax:10090),Gene) :: ['MCP-1']


abstract: UNASSIGNED: Despite the high risk of @entity5 to the population, Korean Americans are known to have lower knowledge about @entity5 related information and a lower level of adherence to @entity5 prevention guidelines. This indicates the necessity of @entity5 interventions targeting the Korean American population. To reach this population effectively, it is imperative to understand Korean Americans' @entity5 information seeking behaviors. This study (a) identified @entity5 information sources that are trusted and used by Korean American @entity1 and (b) examined how general media exposure and trust in @entity5 information sources are related to the use of these sources. It also (c) explored perceived usefulness and limitations of @entity5 information sources. A mixed methods study using seven focus group interviews with 34 Korean American @entity1 and surveys with 152 Korean American @entity1 was conducted in the Washington, DC, metropolitan area from 2011 to 2012. The results indicate that Korean American @entity1 viewed health care professionals as the most trusted @entity5 information source but used the Internet and Korean ethnic media more often for @entity5 information seeking because of language, cultural, and economic barriers. Korean American @entity1 were most likely to obtain @entity5 information from media they used frequently for general purposes. Correlations between usage frequency and trust in doctor/health providers and the Internet as @entity5 information sources were negligible. When seeking @entity5 information, important factors for Korean American @entity1 were accessibility, affordability, and language proficiency, cultural sensitivity, meeting immediate needs, understandability, convenience, and reliability of @entity5 information sources. Findings from this study support developing interventions using Korean language media, including print, television and the Internet for health promotion and @entity5 prevention targeting Korean American @entity1 .

title: Cancer Information Seeking Behaviors of Korean American XXXX : A Mixed-Methods Study Using Surveys and Focus Group Interviews.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: PURPOSE: Current clinical practice guidelines sometimes still recommend stopping @entity117 five to seven days before knee arthroplasty surgery. Literature regarding multimodal blood management and continuation of anti-platelet therapy in this type of surgery is scant. The study hypothesis was that knee arthroplasty under low-dose @entity117 mono-therapy continuation does not cause more @entity190 than knee arthroplasty performed without @entity117 . @entity190 would be measured by haemoglobin (Hb) and haematocrit (HTC) levels drop at day 2 or day 4 for @entity1 who benefit from multimodal @entity548 control measures. METHODS: A database of all @entity1 undergoing knee arthroplasty between 2006 and 2014 was analysed. @entity1503 were collected. A retrospective comparison study analysed both groups in terms of @entity190 , by mean calculated @entity190 as haemoglobin or haematocrit drop between the preoperative Nadir value and the postoperative day 2 and 4 value. A group of 198 (44 UKA and 154 TKA) @entity1 underwent surgery without interrupting their @entity117 therapy for cardiovascular prevention. Mean (SD) age was 71 (8) and the mean (SD) BMI was 29 (5.5) kg/m(2). The control group consisted of 403 (102 UKA and 301 TKA) @entity1 who were not under @entity117 , or any other anti-platelet agent. Mean (SD) age was 65 (10) (p  <  0.05) and the mean (SD) BMI was 29 (5.0) kg/m(2) (n.s.). All @entity1 in the control group were randomly selected. RESULTS: There were no differences in terms of visible (early) or hidden (late) @entity190 as measured by Hb drop in between both groups. There is no difference in transfusion rates. CONCLUSIONS: Modern multimodal blood management provides sufficient @entity190 prevention during and after knee arthroplasty to allow physicians to continue low-dose @entity117 mono-therapy for cardiovascular prevention. LEVEL OF EVIDENCE: III.

title: XXXX mono-therapy continuation does not result in more @entity548 after knee arthroplasty.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'total blood loss', 'Blood loss']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['Demographic, surgical and complete blood workup data']

answer: @entity117 :: (MESH:D001241,Chemical) :: ['Aspirin']


abstract: PURPOSE: Current clinical practice guidelines sometimes still recommend stopping @entity117 five to seven days before knee arthroplasty surgery. Literature regarding multimodal blood management and continuation of anti-platelet therapy in this type of surgery is scant. The study hypothesis was that knee arthroplasty under low-dose @entity117 mono-therapy continuation does not cause more @entity190 than knee arthroplasty performed without @entity117 . @entity190 would be measured by haemoglobin (Hb) and haematocrit (HTC) levels drop at day 2 or day 4 for @entity1 who benefit from multimodal @entity548 control measures. METHODS: A database of all @entity1 undergoing knee arthroplasty between 2006 and 2014 was analysed. @entity1503 were collected. A retrospective comparison study analysed both groups in terms of @entity190 , by mean calculated @entity190 as haemoglobin or haematocrit drop between the preoperative Nadir value and the postoperative day 2 and 4 value. A group of 198 (44 UKA and 154 TKA) @entity1 underwent surgery without interrupting their @entity117 therapy for cardiovascular prevention. Mean (SD) age was 71 (8) and the mean (SD) BMI was 29 (5.5) kg/m(2). The control group consisted of 403 (102 UKA and 301 TKA) @entity1 who were not under @entity117 , or any other anti-platelet agent. Mean (SD) age was 65 (10) (p  <  0.05) and the mean (SD) BMI was 29 (5.0) kg/m(2) (n.s.). All @entity1 in the control group were randomly selected. RESULTS: There were no differences in terms of visible (early) or hidden (late) @entity190 as measured by Hb drop in between both groups. There is no difference in transfusion rates. CONCLUSIONS: Modern multimodal blood management provides sufficient @entity190 prevention during and after knee arthroplasty to allow physicians to continue low-dose @entity117 mono-therapy for cardiovascular prevention. LEVEL OF EVIDENCE: III.

title: @entity117 mono-therapy continuation does not result in more XXXX after knee arthroplasty.

answer: @entity548 :: (MESH:D006470,Disease) :: ['bleeding']


abstract: @entity2688 is rare and mostly occurs because of @entity1244 and dental procedures. Furthermore, cellulitis caused by iatrogenic foreign bodies is very rare. A 28-year-old @entity1 who had previously undergone cosmetic bimaxillary operation visited our hospital complaining of left facial swelling, @entity158 , and nasal obstruction since 2 years. She had been attending another clinic, but despite having additional procedures and taking medications, her symptoms persisted. A subsequent operation was performed, during which we found a remnant surgical gauze from the previous operation, which was decomposed and trapped around the @entity39 soft tissue and had eroded the bony structure around the pterygoid fossa. The material was successfully removed by endoscopic surgery, and the @entity39 tissue was debrided. After the operation, all symptoms disappeared, and the @entity1 was discharged without sequelae. During any procedure, surgeons must meticulously check for remnant material. Additionally, physicians must carefully note @entity1 history and perform a physical examination, even in @entity1 without serious symptoms. We report a case of advanced @entity2688 due to remnant gauze material during a previous operation that was undetected.

title: XXXX caused by a remnant iatrogenic foreign body after a bimaxillary operation.

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic']

entities_list: @entity2688 :: ('MESH:D002481', 'Disease') :: ['infratemporal fossa cellulitis', 'Infratemporal fossa cellulitis']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['oppressive pain']

answer: @entity2688 :: (MESH:D002481,Disease) :: ['Infratemporal fossa cellulitis']


abstract: Invasive @entity189 has been shown to be etiologically heterogeneous on the basis of pathological, virological, and epidemiological criteria. @entity1082 -related invasive @entity189 has basaloid or warty morphology and has adjacent basaloid or warty @entity5436 . @entity189 unrelated to @entity1082 is a keratinizing @entity957 that may have adjacent @entity1373 . We provided to 3 pathologists for their review and pathological diagnoses stained tissue sections from 95 @entity1 with @entity189 . The reproducibility for grading individual categories of intraepithelial lesions was only fair (kappa values of 0.31-0.43). The reproducibility was better (moderate to good; kappa values of 0.58-0.59) for grading individual categories of invasive @entity189 . The agreements improved when the basaloid and warty categories were combined. Good agreement was achieved (kappa values of 0.55-0.79) in distinguishing @entity1082 -related lesions from those unrelated to @entity1082 ; all three reviewers agreed on this classification for 67% of the cases. The intrareviewer agreement was of the same order as interreviewer agreement. Difficulties in differentiating between some lesions (e.g., a @entity189 with little atypia from a well- to moderately differentiated keratinizing @entity957 ) and concurrent occurrence of @entity1082 -related lesions and those lesions unrelated to @entity1082 in a @entity1 may account for some of the discrepancies in the histopathological diagnoses of @entity189 .

title: Reproducibility of the histopathological classification of XXXX and @entity5436 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['squamous hyperplasia']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['vulvar carcinoma', 'carcinomas', 'Invasive carcinoma', 'warty carcinoma']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus', 'Human papillomavirus']

entities_list: @entity5436 :: ('MESH:D019048', 'Disease') :: ['intraepithelial neoplasia']

answer: @entity957 :: (MESH:D002294,Disease) :: ['vulvar squamous carcinoma']


abstract: Invasive @entity189 has been shown to be etiologically heterogeneous on the basis of pathological, virological, and epidemiological criteria. @entity1082 -related invasive @entity189 has basaloid or warty morphology and has adjacent basaloid or warty @entity5436 . @entity189 unrelated to @entity1082 is a keratinizing @entity957 that may have adjacent @entity1373 . We provided to 3 pathologists for their review and pathological diagnoses stained tissue sections from 95 @entity1 with @entity189 . The reproducibility for grading individual categories of intraepithelial lesions was only fair (kappa values of 0.31-0.43). The reproducibility was better (moderate to good; kappa values of 0.58-0.59) for grading individual categories of invasive @entity189 . The agreements improved when the basaloid and warty categories were combined. Good agreement was achieved (kappa values of 0.55-0.79) in distinguishing @entity1082 -related lesions from those unrelated to @entity1082 ; all three reviewers agreed on this classification for 67% of the cases. The intrareviewer agreement was of the same order as interreviewer agreement. Difficulties in differentiating between some lesions (e.g., a @entity189 with little atypia from a well- to moderately differentiated keratinizing @entity957 ) and concurrent occurrence of @entity1082 -related lesions and those lesions unrelated to @entity1082 in a @entity1 may account for some of the discrepancies in the histopathological diagnoses of @entity189 .

title: Reproducibility of the histopathological classification of @entity957 and XXXX .

answer: @entity5436 :: (MESH:D019048,Disease) :: ['intraepithelial neoplasia']


abstract: INTRODUCTION: Few studies have investigated links between @entity1 abuse and neglect and @entity6 in nationally representative samples, and none have explored the role of @entity28 in the relationship. We sought to determine whether @entity1 abuse and neglect were associated with @entity6 and if so, whether @entity28 mediated this relationship in a population-representative sample of young adults. METHODS: We used data from 14,493 @entity1 aged 24 to 34 years from Wave IV of the National Longitudinal Study of Adolescent Health to study associations between self-reported @entity1 abuse ( @entity458 ) and neglect as @entity1 and @entity6 or @entity5710 in young adulthood. We conducted sex-stratified logistic regression analyses to evaluate associations in models before and after the addition of body mass index (BMI) as a covariate. RESULTS: Although the prevalence of @entity6 was similar for @entity1 and @entity1 (7.0% vs 6.7%), @entity1 were more likely than @entity1 to have @entity5710 (36.3% vs 24.6%; omnibus P < .001). Among @entity1 , recurrent @entity458 (>= 3 lifetime incidents) was significantly associated with @entity6 (OR, 3.66; 95% CI, 1.31-10.24), but not with @entity5710 . There was no evidence of mediation by BMI. No forms of @entity1 abuse or neglect were associated with @entity6 or @entity5710 among @entity1 . CONCLUSIONS: Recurrent @entity458 is robustly associated with @entity6 in young adult @entity1 , independently of other forms of @entity1 abuse or neglect and BMI. Future research should explore other potential mechanisms for this association to identify avenues for prevention of @entity6 among @entity1 who have experienced @entity458 .

title: Relationship Between Abuse and Neglect in Childhood and XXXX in Adulthood: Differential Effects By Sex, National Longitudinal Study of Adolescent Health.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'children', 'child', 'men']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus']

entities_list: @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetes']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual abuse', 'sexual, physical, or emotional abuse']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: BACKGROUND AND AIM: Mesenchymal precursor cells (MPC) are reported to possess immunomodulatory properties that may prove beneficial in autoimmune and other inflammatory conditions. However, their mechanism of action is poorly understood. A collagen-induced @entity625 model has been previously developed which demonstrates @entity32 and systemic inflammatory changes. These include not only increased levels of inflammatory markers, but also vascular endothelial cell dysfunction, characterised by reduced endothelium-dependent vasodilation. This study aimed to characterise the changes in systemic inflammatory markers and endothelial function following the intravenous administration of MPC, in the ovine model. METHODS: @entity625 was induced in sixteen adult @entity742 by administration of @entity291 type II collagen into the hock joint following initial sensitisation. After 24h, @entity742 were administered either 150 million allogeneic ovine MPCs intravenously, or saline only. Fibrinogen and serum amyloid-A were measured in plasma to assess systemic @entity32 , along with pro-inflammatory and anti-inflammatory cytokines. Animals were necropsied two weeks following @entity625 induction. Coronary and digital arterial segments were mounted in a Mulvaney-Halpern wire myograph. The relaxant response to endothelium-dependent and endothelium-independent vasodilators was used to assess @entity409 . RESULTS AND CONCLUSION: Arthritic @entity742 treated with MPC demonstrated a marked spike in plasma @entity71864 , 24h following MPC administration. They also showed significantly reduced plasma levels of the inflammatory markers, fibrinogen and serum amyloid A, and increased HDL. Coronary arteries from RA @entity742 treated with MPCs demonstrated a significantly greater maximal relaxation to @entity1812 when compared to untreated RA @entity742 (253.6    17.1% of pre-contracted tone vs. 182.3    27.3% in controls), and digital arteries also demonstrated greater endothelium-dependent vasodilation. This study demonstrated that MPCs given intravenously are able to attenuate systemic inflammatory changes associated with a monoarthritis, including the development of @entity409 .

title: Effect of Mesenchymal Precursor Cells on the Systemic Inflammatory Response and Endothelial Dysfunction in an Ovine Model of Collagen-Induced XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'local joint inflammation']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis', 'Arthritis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction']

entities_list: @entity1812 :: ('MESH:D001920', 'Chemical') :: ['bradykinin']

answer: @entity625 :: (MESH:D001168,Disease) :: ['Arthritis']


abstract: BACKGROUND: The authors' objective was to determine retrospectively the methods used to follow up @entity1358 of undetermined significance (AGUS) on Papanicolaou smears and to evaluate the effectiveness of those methods. MATERIAL AND METHODS: The charts of all @entity1 with AGUS smears obtained between February 1993 and April 1996 were reviewed retrospectively, and information was extracted. A computer database was used to identify the @entity1 and review the method of evaluation. The findings from histological sampling also are reported and analyzed. All findings are reported descriptively. RESULTS: Seventy-nine AGUS smears were evaluated. Of these, it was found that six @entity1 had no follow-up. Of the 62 with histological followup, most (74%) underwent colposcopy, endometrial biopsy (63%), or endocervical curettage (50%). Cervical or vaginal biopsy, cervical conization, hysteroscopy, and hysterectomy also were performed. Twenty-seven @entity1 underwent more than one procedure for tissue sampling. Of the 62 @entity1 from whom histological samples were taken, 18 (29%) were found to have clinically significant lesions, 11 of which were @entity189 . CONCLUSIONS: In our clinic, AGUS smears are a result of a significant number of high-grade neoplastic findings. Histological evaluation is necessary in most cases for accurate diagnosis because of the multiple, varied potential etiologies of AGUS smears.

title: Papanicolaou smears showing XXXX of undetermined significance: a case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['atypical glandular cells']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['atypical glandular cells']