abstract: Disseminated @entity5 in a 71-year-old male represented the first clinical manifestation of a @entity6130 . The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for @entity4483 protein. The simultaneous presence of immature myeloid cells led to the suspicion of an underlying @entity6961 . The diagnosis of @entity6130 was subsequently confirmed by bone marrow histology and blood picture. Although some peritrabecular foci of histiocytic cells were detected in bone marrow, no LC could be identified by electron microscopy and histochemical methods. Tumorous aggregates of LC in @entity6961 have not been described in the literature. @entity1112 could be definitely excluded in the present case. This case obviously suggests an interrelation between the @entity66 and the focal accumulation of LC in the dermis. In animal studies by Katz et al. LC have been shown to originate in the bone marrow, whereas the origin of LC in @entity1 is still a matter of discussion. The present case supports the hypothesis that LC in @entity1 are also of myeloid origin. The neoplastic blood monocytes could be the precursors of the dermal LC. This differentiation did not take place in the bone marrow but only in the dermis where LC occur under nonneoplastic conditions ("homing").

title: @entity5 in XXXX .

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['myeloproliferative disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['dermal tumors']

entities_list: @entity6130 :: ('MESH:D015477', 'Disease') :: ['chronic myelomonocytic leukemia']

entities_list: @entity1112 :: ('MESH:D040181', 'Disease') :: ['Histiocytosis X and related diseases']

entities_list: @entity6961 :: ('MESH:D009196', 'Disease') :: ['myeloproliferative disorder', 'myeloproliferative disorders']

answer: @entity6130 :: (MESH:D015477,Disease) :: ['chronic myelomonocytic leukemia']


abstract: Disseminated @entity5 in a 71-year-old male represented the first clinical manifestation of a @entity6130 . The dermal infiltrate in one of the nodules consisted predominantly of closely packed pleomorphic Langerhans' cells (LC) with typical Birbeck granules and a strong reactivity for @entity4483 protein. The simultaneous presence of immature myeloid cells led to the suspicion of an underlying @entity6961 . The diagnosis of @entity6130 was subsequently confirmed by bone marrow histology and blood picture. Although some peritrabecular foci of histiocytic cells were detected in bone marrow, no LC could be identified by electron microscopy and histochemical methods. Tumorous aggregates of LC in @entity6961 have not been described in the literature. @entity1112 could be definitely excluded in the present case. This case obviously suggests an interrelation between the @entity66 and the focal accumulation of LC in the dermis. In animal studies by Katz et al. LC have been shown to originate in the bone marrow, whereas the origin of LC in @entity1 is still a matter of discussion. The present case supports the hypothesis that LC in @entity1 are also of myeloid origin. The neoplastic blood monocytes could be the precursors of the dermal LC. This differentiation did not take place in the bone marrow but only in the dermis where LC occur under nonneoplastic conditions ("homing").

title: XXXX in @entity6130 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['Dermal Langerhans' cell tumor']


abstract: The present study was performed in order to evaluate the diagnostic usefulness of serial @entity165 and @entity1674 measurements in @entity1 with severe burns. One of the main objective was to find out if these parameters are clinically relevant to determine the morbidity of a burn @entity1 and thereby the @entity1 's outcome. In 220 @entity1 with thermal injuries, @entity165 and @entity412 concentrations were measured daily. Blood samples were drawn immediately upon admission and thereafter daily until @entity1 's discharge or @entity204 . For both parameters, a characteristic course was noted: in the group of non-survivors, a decrease of @entity165 prior to @entity204 was noted, while survivors, increased prior to discharge. The time courses of both groups (survivors-non-survivors) differed statistically significantly (P=0.0068). An increase in @entity1674 was observed in all non-survivors prior to @entity204 , but in the group of survivors @entity1674 remained more or less unchanged. These time courses also had statistically significant differences (P=0.0004). In our 220 @entity1 , changes in @entity165 (P<0.0001, hazard ratio 1.02) and @entity1674 (P=0.0008, hazard ratio 1.01) had comparable capability to predict the severity of a burn @entity130 and thereby its outcome than the established parameters in the treatment of burns (total body surface area burned, age, inhalation). We consider the serial measurements of @entity165 and @entity1674 as clinically relevant to assess the morbidity of a @entity1 and thereby to estimate the @entity1 's outcome. We think that these serial measurements provide useful information for the clinician treating @entity1 with severe burns.

title: Serum @entity165 and XXXX : potential role in mortality prediction.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1674 :: (MESH:D014280,Chemical) :: ['triglycerides']


abstract: The present study was performed in order to evaluate the diagnostic usefulness of serial @entity165 and @entity1674 measurements in @entity1 with severe burns. One of the main objective was to find out if these parameters are clinically relevant to determine the morbidity of a burn @entity1 and thereby the @entity1 's outcome. In 220 @entity1 with thermal injuries, @entity165 and @entity412 concentrations were measured daily. Blood samples were drawn immediately upon admission and thereafter daily until @entity1 's discharge or @entity204 . For both parameters, a characteristic course was noted: in the group of non-survivors, a decrease of @entity165 prior to @entity204 was noted, while survivors, increased prior to discharge. The time courses of both groups (survivors-non-survivors) differed statistically significantly (P=0.0068). An increase in @entity1674 was observed in all non-survivors prior to @entity204 , but in the group of survivors @entity1674 remained more or less unchanged. These time courses also had statistically significant differences (P=0.0004). In our 220 @entity1 , changes in @entity165 (P<0.0001, hazard ratio 1.02) and @entity1674 (P=0.0008, hazard ratio 1.01) had comparable capability to predict the severity of a burn @entity130 and thereby its outcome than the established parameters in the treatment of burns (total body surface area burned, age, inhalation). We consider the serial measurements of @entity165 and @entity1674 as clinically relevant to assess the morbidity of a @entity1 and thereby to estimate the @entity1 's outcome. We think that these serial measurements provide useful information for the clinician treating @entity1 with severe burns.

title: Serum XXXX and @entity1674 : potential role in mortality prediction.

answer: @entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']


abstract: Burns caused by hot coolant from the reservoir of motorfarming tricycles have not been reported previously. We performed retrospective studies of such cases in 126 @entity1 with complete records in rural areas of China. The majority of victims were unmarried (59.5%), young (<40 years, >20, 55.6%), and male (male to female ratio 9:1). The burn accident occurred mostly during the busy seasons of spring and summer (66.7%). The mechanism of injury was usually the same. The drivers were trapped under the farming tricycle in a traffic accident and then hot coolant leaked from the mouth of the coolant, resulting in long contact with the hot fluid. The burn wounds were located mostly on the areas of the buttocks and lower extremities (especially on the thigh) (64.3%). The generally burned @entity1 had moderate burn areas, about 20-50% total burn surface area (TBSA) of deep partial @entity121 or @entity4808 wound. For the purpose of decreasing the number of burns presenting, or at least making them less severe, the suggestions include: (1) the design of motorfarming tricycle should be changed; obviously separation of the coolant @entity3368 from the seat is the most important factor in reducing such burns. (2) Road conditions should be improved to reduce traffic accidents and loading regulations introduced. (3) Traffic control should be enhanced, especially in rural areas.

title: Burn injuries associated with the water XXXX of motorfarming tricycles in China.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['thickness']

entities_list: @entity4808 :: ('MESH:D002056', 'Disease') :: ['full thickness burn']

answer: @entity3368 :: (10010,Gene) :: ['tank']


abstract: This study assesses the prognostic value of @entity296 recognized as a contractile response to inotropic stimulation in @entity1 with @entity1002 in a large-scale prospective, multicenter, observational study. Four hundred twenty-five @entity1 (mean age 61 +/- 10 years) with angiographically proven @entity453 , previous (>3 months) @entity583 , and severe @entity1002 (ejection fraction <35%; mean 28 +/- 6%) were enrolled in the study. Each @entity1 underwent low-dose @entity452 echocardiography (up to 10 microg/kg/min). Myocardial viability was identified as a rest-stress variation (Delta) in the wall motion score index (WMSI), in which each segment was scored from 1 = normal to 4 = dyskinetic in a 16-segment model of the left ventricle. Myocardial viability was identified as an improvement of >/=0.40 in WMSI. All @entity1 were followed for a median of 3.1 years. One hundred eighty-eight were revascularized either by coronary artery bypass grafting (n = 118) or coronary angioplasty (n = 70). The only end point analyzed was @entity204 . In the revascularized group, @entity204 occurred in 4 of the 52 @entity1 with and in 37 of the 136 @entity1 without @entity296 (7.7% vs 27.2%, p <0.003). Kaplan-Meier survival estimates showed a better outcome for those @entity1 with compared to @entity1 without @entity296 who underwent coronary revascularization (90.1% vs 62%, p <0.0078). Thus, in severe @entity1002 , @entity296 by low-dose @entity452 echocardiography is associated with improved survival in revascularized @entity1 .

title: Prognostic value of XXXX recognized by low-dose @entity452 echocardiography in chronic @entity1002 .

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial viability']

entities_list: @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular (LV) dysfunction', 'LV dysfunction', 'LV ischemic dysfunction']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial viability']


abstract: This study assesses the prognostic value of @entity296 recognized as a contractile response to inotropic stimulation in @entity1 with @entity1002 in a large-scale prospective, multicenter, observational study. Four hundred twenty-five @entity1 (mean age 61 +/- 10 years) with angiographically proven @entity453 , previous (>3 months) @entity583 , and severe @entity1002 (ejection fraction <35%; mean 28 +/- 6%) were enrolled in the study. Each @entity1 underwent low-dose @entity452 echocardiography (up to 10 microg/kg/min). Myocardial viability was identified as a rest-stress variation (Delta) in the wall motion score index (WMSI), in which each segment was scored from 1 = normal to 4 = dyskinetic in a 16-segment model of the left ventricle. Myocardial viability was identified as an improvement of >/=0.40 in WMSI. All @entity1 were followed for a median of 3.1 years. One hundred eighty-eight were revascularized either by coronary artery bypass grafting (n = 118) or coronary angioplasty (n = 70). The only end point analyzed was @entity204 . In the revascularized group, @entity204 occurred in 4 of the 52 @entity1 with and in 37 of the 136 @entity1 without @entity296 (7.7% vs 27.2%, p <0.003). Kaplan-Meier survival estimates showed a better outcome for those @entity1 with compared to @entity1 without @entity296 who underwent coronary revascularization (90.1% vs 62%, p <0.0078). Thus, in severe @entity1002 , @entity296 by low-dose @entity452 echocardiography is associated with improved survival in revascularized @entity1 .

title: Prognostic value of @entity296 recognized by low-dose @entity452 echocardiography in chronic XXXX .

answer: @entity1002 :: (MESH:D018487,Disease) :: ['ischemic left ventricular dysfunction']


abstract: This study assesses the prognostic value of @entity296 recognized as a contractile response to inotropic stimulation in @entity1 with @entity1002 in a large-scale prospective, multicenter, observational study. Four hundred twenty-five @entity1 (mean age 61 +/- 10 years) with angiographically proven @entity453 , previous (>3 months) @entity583 , and severe @entity1002 (ejection fraction <35%; mean 28 +/- 6%) were enrolled in the study. Each @entity1 underwent low-dose @entity452 echocardiography (up to 10 microg/kg/min). Myocardial viability was identified as a rest-stress variation (Delta) in the wall motion score index (WMSI), in which each segment was scored from 1 = normal to 4 = dyskinetic in a 16-segment model of the left ventricle. Myocardial viability was identified as an improvement of >/=0.40 in WMSI. All @entity1 were followed for a median of 3.1 years. One hundred eighty-eight were revascularized either by coronary artery bypass grafting (n = 118) or coronary angioplasty (n = 70). The only end point analyzed was @entity204 . In the revascularized group, @entity204 occurred in 4 of the 52 @entity1 with and in 37 of the 136 @entity1 without @entity296 (7.7% vs 27.2%, p <0.003). Kaplan-Meier survival estimates showed a better outcome for those @entity1 with compared to @entity1 without @entity296 who underwent coronary revascularization (90.1% vs 62%, p <0.0078). Thus, in severe @entity1002 , @entity296 by low-dose @entity452 echocardiography is associated with improved survival in revascularized @entity1 .

title: Prognostic value of @entity296 recognized by low-dose XXXX echocardiography in chronic @entity1002 .

answer: @entity452 :: (MESH:D004280,Chemical) :: ['dobutamine']


abstract: BACKGROUND: @entity26 free radicals have been implicated as mediators of @entity3145 in @entity1 of @entity309 ( @entity309 ). This study was designed to elucidate plasma oxidant/antioxidant status in @entity309 , with the aim of evaluating the importance of antioxidant therapy in the management of this disease. METHODS: The study included 40 @entity1 of @entity309 who were randomly divided into two subgroups of 20 each. One group received conventional treatment for 12 weeks and in the other group conventional treatment was supplemented with antioxidants for the same duration. Twenty age- and sex-matched normal individuals constituted the control group. Blood samples of controls and @entity1 were collected at the time of presentation and analyzed for total @entity1433 , @entity2041 , @entity620 and @entity1234 ( @entity1865 -marker of oxidative stress). The investigations were repeated in the @entity1 after 12 weeks. RESULTS: The blood concentrations of total @entity1433 , @entity2041 and @entity620 were found to be significantly lower in @entity309 @entity1 as compared to healthy controls, while the concentrations of @entity1865 were much higher. There was a statistically significant increase in the posttreatment concentrations of these antioxidants, along with a decrease in the concentrations of @entity1865 . CONCLUSIONS: The antioxidant defense system is compromised in @entity309 @entity1 . There is a shift in the oxidant/antioxidant balance in favor of lipid peroxidation, which could lead to the @entity3145 observed in the disease. The results suggest the necessity for therapeutic co-administration of antioxidants along with conventional drugs to such @entity1 . However, due to the limited number of cases included in this study, more studies may be required to substantiate the results and arrive at a definite conclusion, in terms of safety and efficacy of adding on antioxidant therapy for the treatment of @entity309 .

title: Antioxidant status in XXXX and role of antioxidant therapy.

entities_list: @entity3145 :: ('MESH:D017695', 'Disease') :: ['tissue damage']

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['vitamin C']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['Oxygen']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malondialdehyde']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: An attempt has been made to determine if the structural renewal of bone tissue takes place to a greater extent in the spongiosa than in the compacta and how this is related to the more extensive free surface area in the former. To this purpose, on transverse sections of the femur and 2 degrees lumbar vertebral body of the female lactating @entity35 fed a normal (L group) or a @entity460 free diet (H group) the area of compact and spongy bone, and the perimeter of the trabeculae were measured. Then TBV, MTPT, MTPD, MTPS, Sv and S/V, according to the Parfitt et al. (1983) method were calculated. In the femurs of @entity35 maintained on a normal @entity460 diet @entity604 takes place to a higher degree in the spongiosa than in the compacta. In the distal metaphysis, moreover, the @entity604 is more elevated than in other femoral regions. In the second lumbar vertebral body the bone rarefaction appears to have a similar extent in the compacta and spongiosa and in the three levels inspected. In @entity35 maintained on a restricted @entity460 intake the @entity170 is enhanced but the bone is removed predominantly from the compacta in all the femoral regions except in the distal metaphysis and, to a similar degree, from the compacta and the spongiosa of the vertebral body. In the centrodiaphyseal compacta the bone is reabsorbed exclusively at the endosteal level, while in the spongiosa the frameworks subjected to a more extensive resorption occupy a topographic position specific for each single region, and are often formed of thin trabeculae. The dynamic of the trabecular resorption seems to be different in the various spongy frameworks: in each of these it would take place by the removal of the entire trabecula or the thinning of the single trabeculae or by both mechanisms. Lastly, significative correlation was found between trabecular @entity604 and trabecular thickness, none with trabecular surfaces. This study shows that bone removal is not regulated by the extent of the trabecular free surface. The mechanisms involved in the control of the distribution of bone removal are strictly connected with those controlling the trabecular thickness. They are probably of a mechanical nature.

title: Distribution of resorption processes in the compacta and spongiosa of bones from lactating @entity35 fed a low- XXXX diet.

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: An attempt has been made to determine if the structural renewal of bone tissue takes place to a greater extent in the spongiosa than in the compacta and how this is related to the more extensive free surface area in the former. To this purpose, on transverse sections of the femur and 2 degrees lumbar vertebral body of the female lactating @entity35 fed a normal (L group) or a @entity460 free diet (H group) the area of compact and spongy bone, and the perimeter of the trabeculae were measured. Then TBV, MTPT, MTPD, MTPS, Sv and S/V, according to the Parfitt et al. (1983) method were calculated. In the femurs of @entity35 maintained on a normal @entity460 diet @entity604 takes place to a higher degree in the spongiosa than in the compacta. In the distal metaphysis, moreover, the @entity604 is more elevated than in other femoral regions. In the second lumbar vertebral body the bone rarefaction appears to have a similar extent in the compacta and spongiosa and in the three levels inspected. In @entity35 maintained on a restricted @entity460 intake the @entity170 is enhanced but the bone is removed predominantly from the compacta in all the femoral regions except in the distal metaphysis and, to a similar degree, from the compacta and the spongiosa of the vertebral body. In the centrodiaphyseal compacta the bone is reabsorbed exclusively at the endosteal level, while in the spongiosa the frameworks subjected to a more extensive resorption occupy a topographic position specific for each single region, and are often formed of thin trabeculae. The dynamic of the trabecular resorption seems to be different in the various spongy frameworks: in each of these it would take place by the removal of the entire trabecula or the thinning of the single trabeculae or by both mechanisms. Lastly, significative correlation was found between trabecular @entity604 and trabecular thickness, none with trabecular surfaces. This study shows that bone removal is not regulated by the extent of the trabecular free surface. The mechanisms involved in the control of the distribution of bone removal are strictly connected with those controlling the trabecular thickness. They are probably of a mechanical nature.

title: Distribution of resorption processes in the compacta and spongiosa of bones from lactating XXXX fed a low- @entity460 diet.

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: 33 subjects with evidence of active @entity2520 were treated by modified Widman flap surgery and systemic @entity803 (1 g/day for 21 days). @entity527 samples were taken from 41 sites in 12 of these subjects before and 6 months after therapy for predominant cultivable microbiota studies. Mean pocket depth and attachment levels in the 41 sampled sites were 7.1 +/- 2.9 mm and 7.7 +/- 3.2 mm prior to therapy and 4.8 +/- 2.3 mm and 6.2 +/- 3.4 mm after therapy. @entity11625 and @entity23613 were more frequently detected in samples taken after therapy, while @entity2868 , S. morbillorum, @entity8211 and W. recta were less frequently detected after therapy. A. actinomycetemcomitans were detected in 7 sites pretherapy and 1 site post therapy. The frequency of detection of @entity2523 and @entity3288 was virtually unchanged. The mean levels of the Actinomyces sp., A. actinomycetemcomitans, @entity2523 , @entity3288 , S. morbillorum, @entity8211 and W. recta were decreased after therapy, while the mean levels of @entity11625 , @entity6419 , @entity885 II and @entity23613 were increased after therapy. @entity23613 showed the greatest increase to 8.2% of the microbiota. In the second phase of the study, @entity527 samples from 94 sites in the 33 treated subjects were analyzed by predominant cultivable techniques. As a result of therapy, 24 sites exhibited @entity6730 greater than 2 mm, 23 sites exhibited "gain" greater than 2 mm and the remaining 47 sites were considered to be unchanging.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Effect of modified Widman flap surgery and systemic XXXX on the subgingival microbiota of periodontal lesions.

entities_list: @entity6730 :: ('MESH:D017622', 'Disease') :: ['attachment loss']

entities_list: @entity2868 :: ('817', 'Species') :: ['S. intermedius']

entities_list: @entity527 :: ('MESH:D058225', 'Disease') :: ['subgingival plaque', 'Subgingival plaque']

entities_list: @entity2520 :: ('MESH:D010510', 'Disease') :: ['destructive periodontal disease']

entities_list: @entity11625 :: ('28132', 'Species') :: ['B. melaninogenicus']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

entities_list: @entity2523 :: ('837', 'Species') :: ['B. gingivalis']

answer: @entity803 :: (MESH:D013752,Chemical) :: ['tetracycline']


abstract: @entity17590 ) inhibits @entity9302 (interleukin (IL)-1beta-converting enzyme) and @entity10807 , thereby regulating production of the pro-inflammatory cytokine @entity1356 and susceptibility to @entity10807 -induced apoptosis. We show that cellular @entity17590 mRNA and protein are induced by @entity1356 , lipopolysaccharide, and @entity864 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity1178 ( @entity1178 ) site at -308 in the @entity17590 promoter region. Using transient transfections in HepG2 cells to assay @entity17590 promoter mutations, we find that mutational ablation of the @entity1178 site or of either NF-kappaB site reduces @entity1356 -induced expression of @entity17590 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity1178 site nearly abolishes both basal and @entity1356 -induced expression of @entity17590 . Nuclear extracts from @entity1356 -treated HepG2 cells exhibited strong, @entity1356 -inducible binding to the NF-kappaB sites and to the @entity1178 site. Electrophoretic mobility shift assays show that after @entity1356 treatment @entity1178 / @entity1639 and @entity23601 bind to the @entity1178 site, whereas the @entity2451 / @entity9135 heterodimer binds to the two NF-kappaB sites. @entity172 induce @entity17590 , but induction of @entity17590 by @entity172 and @entity1356 is not synergistic. In transiently transfected, @entity172 receptor-positive HepG2ER7 cells, @entity172 do not interfere with @entity1356 induction, whereas @entity1356 exhibits dose-dependent repression of @entity172 -inducible @entity17590 expression. Our surprising finding that the pro-inflammatory cytokine @entity1356 strongly induces @entity17590 suggests a novel mechanism for regulating @entity32 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity17590 .

title: Modulators of @entity32 use nuclear factor-kappa B and @entity1178 sites to induce the @entity9302 and XXXX inhibitor, proteinase inhibitor 9.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogens', 'estrogens']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity864 :: ('MESH:C554292|MESH:D013755', 'Chemical') :: ['12-O-tetradecanoylphorbol-13-acetate']

answer: @entity10807 :: (3002,Gene) :: ['granzyme B']


abstract: @entity17590 ) inhibits @entity9302 (interleukin (IL)-1beta-converting enzyme) and @entity10807 , thereby regulating production of the pro-inflammatory cytokine @entity1356 and susceptibility to @entity10807 -induced apoptosis. We show that cellular @entity17590 mRNA and protein are induced by @entity1356 , lipopolysaccharide, and @entity864 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity1178 ( @entity1178 ) site at -308 in the @entity17590 promoter region. Using transient transfections in HepG2 cells to assay @entity17590 promoter mutations, we find that mutational ablation of the @entity1178 site or of either NF-kappaB site reduces @entity1356 -induced expression of @entity17590 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity1178 site nearly abolishes both basal and @entity1356 -induced expression of @entity17590 . Nuclear extracts from @entity1356 -treated HepG2 cells exhibited strong, @entity1356 -inducible binding to the NF-kappaB sites and to the @entity1178 site. Electrophoretic mobility shift assays show that after @entity1356 treatment @entity1178 / @entity1639 and @entity23601 bind to the @entity1178 site, whereas the @entity2451 / @entity9135 heterodimer binds to the two NF-kappaB sites. @entity172 induce @entity17590 , but induction of @entity17590 by @entity172 and @entity1356 is not synergistic. In transiently transfected, @entity172 receptor-positive HepG2ER7 cells, @entity172 do not interfere with @entity1356 induction, whereas @entity1356 exhibits dose-dependent repression of @entity172 -inducible @entity17590 expression. Our surprising finding that the pro-inflammatory cytokine @entity1356 strongly induces @entity17590 suggests a novel mechanism for regulating @entity32 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity17590 .

title: Modulators of @entity32 use nuclear factor-kappa B and XXXX sites to induce the @entity9302 and @entity10807 inhibitor, proteinase inhibitor 9.

answer: @entity1178 :: (3725,Gene) :: ['activator protein-1']


abstract: @entity17590 ) inhibits @entity9302 (interleukin (IL)-1beta-converting enzyme) and @entity10807 , thereby regulating production of the pro-inflammatory cytokine @entity1356 and susceptibility to @entity10807 -induced apoptosis. We show that cellular @entity17590 mRNA and protein are induced by @entity1356 , lipopolysaccharide, and @entity864 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity1178 ( @entity1178 ) site at -308 in the @entity17590 promoter region. Using transient transfections in HepG2 cells to assay @entity17590 promoter mutations, we find that mutational ablation of the @entity1178 site or of either NF-kappaB site reduces @entity1356 -induced expression of @entity17590 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity1178 site nearly abolishes both basal and @entity1356 -induced expression of @entity17590 . Nuclear extracts from @entity1356 -treated HepG2 cells exhibited strong, @entity1356 -inducible binding to the NF-kappaB sites and to the @entity1178 site. Electrophoretic mobility shift assays show that after @entity1356 treatment @entity1178 / @entity1639 and @entity23601 bind to the @entity1178 site, whereas the @entity2451 / @entity9135 heterodimer binds to the two NF-kappaB sites. @entity172 induce @entity17590 , but induction of @entity17590 by @entity172 and @entity1356 is not synergistic. In transiently transfected, @entity172 receptor-positive HepG2ER7 cells, @entity172 do not interfere with @entity1356 induction, whereas @entity1356 exhibits dose-dependent repression of @entity172 -inducible @entity17590 expression. Our surprising finding that the pro-inflammatory cytokine @entity1356 strongly induces @entity17590 suggests a novel mechanism for regulating @entity32 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity17590 .

title: Modulators of XXXX use nuclear factor-kappa B and @entity1178 sites to induce the @entity9302 and @entity10807 inhibitor, proteinase inhibitor 9.

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: @entity17590 ) inhibits @entity9302 (interleukin (IL)-1beta-converting enzyme) and @entity10807 , thereby regulating production of the pro-inflammatory cytokine @entity1356 and susceptibility to @entity10807 -induced apoptosis. We show that cellular @entity17590 mRNA and protein are induced by @entity1356 , lipopolysaccharide, and @entity864 . We identified functional imperfect nuclear factor-kappaB (NF-kappaB) sites at -135 and -88 and a consensus @entity1178 ( @entity1178 ) site at -308 in the @entity17590 promoter region. Using transient transfections in HepG2 cells to assay @entity17590 promoter mutations, we find that mutational ablation of the @entity1178 site or of either NF-kappaB site reduces @entity1356 -induced expression of @entity17590 by approximately 60%. Mutational ablation of the two NF-kappaB sites and of the @entity1178 site nearly abolishes both basal and @entity1356 -induced expression of @entity17590 . Nuclear extracts from @entity1356 -treated HepG2 cells exhibited strong, @entity1356 -inducible binding to the NF-kappaB sites and to the @entity1178 site. Electrophoretic mobility shift assays show that after @entity1356 treatment @entity1178 / @entity1639 and @entity23601 bind to the @entity1178 site, whereas the @entity2451 / @entity9135 heterodimer binds to the two NF-kappaB sites. @entity172 induce @entity17590 , but induction of @entity17590 by @entity172 and @entity1356 is not synergistic. In transiently transfected, @entity172 receptor-positive HepG2ER7 cells, @entity172 do not interfere with @entity1356 induction, whereas @entity1356 exhibits dose-dependent repression of @entity172 -inducible @entity17590 expression. Our surprising finding that the pro-inflammatory cytokine @entity1356 strongly induces @entity17590 suggests a novel mechanism for regulating @entity32 and apoptosis through a negative feedback loop controlling expression of the anti-inflammatory and anti-apoptotic protein, @entity17590 .

title: Modulators of @entity32 use nuclear factor-kappa B and @entity1178 sites to induce the XXXX and @entity10807 inhibitor, proteinase inhibitor 9.

answer: @entity9302 :: (834,Gene) :: ['caspase-1']


abstract: BACKGROUND: @entity712 ( @entity712 ) in older adults is often associated with preserved left ventricular systolic function (LVSF). The objective of this retrospective follow-up study was to determine the correlates and outcomes of preserved LVSF among older adults hospitalized with @entity712 . METHODS: We studied older Medicare beneficiaries hospitalized with @entity712 (n = 1091) who had documented LVSF evaluation (n = 438). LVSF was defined as preserved if left ventricular ejection fraction was > or =40%. The Fisher exact test and the Student t test were used to compare baseline characteristics between @entity1 with preserved versus those with impaired LVSF. Multivariate logistic regression analysis was used to determine the correlates of preserved LVSF. Cox proportional hazards analyses were used to determine the associations between LVSF and both 4-year mortality rates and 6-month readmission rates and the associations between @entity1289 ( @entity1289 ) inhibitor use and 4-year mortality rates, separately, in @entity1 with preserved and impaired LVSF. RESULTS: Of the 438 @entity1 , 200 (46%) had preserved LVSF. @entity1 were more likely to have preserved LVSF (odds ratio [OR] = 2.44, 95% CI 1.57-3.81) than @entity1 . Preserved LVSF was associated with lower 4-year mortality rates (adjusted hazards ratio [HR] = 0.67, 95% CI 0.52-0.86) but not with 6-month readmission rates (adjusted HR = 0.66, 95% CI 0.41-1.09). The use of @entity1289 inhibitors was associated with lower 4-year mortality rates in @entity1 with impaired LVSF (adjusted HR = 0.61, 95% CI 0.43-0.86) but not in those with preserved LVSF (HR = 0.96, 95% CI 0.65-1.42). CONCLUSIONS: Among older adults hospitalized with @entity712 , preserved LVSF was common among @entity1 and was associated with significantly higher morbidity and mortality rates, which were unaffected by treatment with @entity1289 inhibitors.

title: Correlates and outcomes of preserved left ventricular systolic function among older adults hospitalized with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women', 'men']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'Heart failure']

entities_list: @entity1289 :: ('1636', 'Gene') :: ['ACE', 'angiotensin-converting enzyme']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: The accuracy of historical information derived from self-administered questionnaires must be confirmed. We report the results of studies conducted to assess the reliability and validity of data collected from a comprehensive @entity5 risk factor questionnaire developed at The University of Texas M.D. Anderson @entity5 Center. A comparison of the basic demographic data of a randomly selected sample of 80 respondents and 70 nonrespondents revealed no fundamental ethnic or socioeconomic differences. We verified self-reported past illnesses, surgical procedures, and @entity5 by reviewing 72 @entity1 charts, using stringent diagnostic criteria for verification. We noted substantial agreement between self-reported and documented illnesses and operations. With the exception of nine @entity1 who misclassified metastatic disease, the verification of primary @entity5 was excellent. We determined reliability by interviewing 50 of these @entity1 by telephone. Questions with a dichotomous outcome (e.g., smoking status) were reliably answered; however, those requiring quantification (e.g., amount of @entity167 consumed) were less accurately reported on interview. While we recognize the limitations of self-administered questionnaires, we believe this program will develop into a comprehensive, standardized, easily accessible @entity1 risk factor data base.

title: The development of a comprehensive, institution-based XXXX risk evaluation program: II. Validity and reliability of questionnaire data.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: BACKGROUND: Recombinant FVIIa (rFVIIa/NovoSeven) is a novel hemostatic agent originally developed to treat @entity1 with @entity447 who had developed inhibitors. Several case reports have suggested that rFVIIa may be effective in treating @entity1 without a pre-existing @entity3459 who have uncontrolled @entity548 . STUDY DESIGN AND METHODS: Data on the efficacy and safety of rFVIIa in the treatment of @entity548 were obtained retrospectively from the NovoSeven extended-use data collection system. RESULTS: A total of 40 @entity1 received rFVIIa for uncontrolled @entity548 , and in these @entity1 , @entity548 stopped or decreased in 32 (80%). Blood product usage was significantly decreased after rFVIIa administration. @entity1031 events occurred in three @entity1 with additional risk factors for @entity715 . Of 40 @entity1 , 23 (57.5%) died. Bleeding was the direct cause of @entity204 in seven cases (all within 24 hr of administration of rFVIIa). The remaining 16 deaths were the result of @entity295 , @entity881 , or the underlying disease. CONCLUSIONS: In this retrospective study of data voluntarily submitted to a web-based drug surveillance program, we present preliminary results on the use of rFVIIa in nonhemophilia @entity1 with @entity548 . Although some efficacy is suggested, there was a high mortality rate from nonhemorrhagic causes. Randomized controlled trials are needed to properly assess the role of rFVIIa in the management of @entity548 .

title: Recombinant FVIIa in the management of uncontrolled XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['massive hemorrhage', 'hemorrhage', 'bleeding']

entities_list: @entity447 :: ('MESH:D006467', 'Disease') :: ['hemophilia']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['bleeding disorder']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['Thromboembolic']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multi-organ failure']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhage']


abstract: BACKGROUND: Posterior horseshoe @entity292 with deep postanal space abscess is a complex disease. Most @entity1 have a history of @entity733 or surgery for @entity292 -in-ano. METHODS: Twenty-five @entity1 who underwent surgery for posterior horseshoe @entity292 with deep postanal space abscess were analyzed retrospectively with respect to age, gender, previous surgery for @entity292 -in-ano, number of external openings, diagnostic studies, concordance between preoperative studies and operative findings for the extent of disease, operating time, healing time, complications, and recurrence. RESULTS: There were 22 (88%) @entity1 and 3 (12%) @entity1 with a median age of 37 (range, 25-58) years. The median duration of disease was 13 (range, 3-96) months. There was one external opening in 12 (48%) @entity1 , 2 in 8 (32%), 3 in 4 (16%), and 4 in 1 (4%). Preoperative diagnosis of horseshoe @entity292 was made by contrast fistulography in 4 (16%) @entity1 , by ultrasound in 3 (12%), by magnetic resonance imaging in 6 (24%), and by physical examination only in the remainder (48%). The mean +/- SD operating time was 47 +/- 10 min. The mean +/- SD healing time was 12 +/- 3 weeks. Three of the 25 @entity1 (12%) had @entity6 . Nineteen (76%) @entity1 had undergone previous surgery for @entity292 -in-ano, while five (20%) had only perianal abscess drainage. Neither morbidity nor mortality developed. All @entity1 were followed up for a median of 35 (range, 6-78) months and no recurrence was observed. CONCLUSIONS: Fistulotomy of the tracts along the arms of horseshoe @entity292 and drainage of the deep postanal space abscess with posterior midline incision that severs both the lower edge of the internal sphincter and the subcutaneous external sphincter and divides the superficial external sphincter into halves gives excellent results with no recurrence. When it is necessary, severing the halves of the superficial external sphincter unilaterally or even bilaterally in the same session does not result in anal @entity322 . Close follow-up of @entity1 until the wounds completely healed is essential in the prevention of premature wound closure and recurrence.

title: Fistulotomy and drainage of deep postanal space abscess in the treatment of posterior horseshoe XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus type II']

entities_list: @entity733 :: ('MESH:D000038', 'Disease') :: ['anorectal abscess drainage']

answer: @entity292 :: (MESH:D005402,Disease) :: ['fistula']


abstract: Marked non-communicating @entity1276 may rarely cause @entity9009 producing either a dilated cystic cavity (ventricular diverticulum) or communication between ventricle system and subarachnoid space (spontaneous ventriculostomy). @entity67 has been believed to be collection of cerebrospinal fluid which escaped beneath the pia mater after rupture of @entity1779 . We proposed herein to report a case of @entity67 which accompanied with @entity2846 of the lateral ventricle. A nine year-old @entity1 admitted to our hospital complaining of clumsiness of hands and walking, disability of reading, @entity10 and @entity391 . The neurological examination revealed @entity5545 , @entity1829 , @entity5562 , @entity1805 , @entity425 of @entity6447 . CT brain scan showed a large high density area at the trigone of the left lateral ventricle with non-communicating @entity1276 and an extra-axial low density area in the posterior fossa. The medial space of the left trigone was especially ballooned and is just shifted above incisura tentoria by the @entity5 . The intraventricular @entity5 was totally removed by operation and proved to be benign @entity2846 microscopically. The subtentorial mass was confirmed to be a cyst contiguous to the medial trigone of the lateral ventricle, namely ventricular diverticulum. Three special features were recognized in this case. The first, this was the first example of @entity9009 accompanied with @entity5 in the lateral ventricle reviewing all reports of both ventricular diverticulum and spontaneous ventriculostomy. The second, this ventricular diverticulum was not produced merely by @entity1276 alone but mainly by direct effects of the @entity5 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of XXXX accompanied with @entity2846 in the lateral ventricle].

entities_list: @entity9009 :: ('MESH:D018658', 'Disease') :: ['ventricular rupture']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1805 :: ('MESH:D006423', 'Disease') :: ['righ hemianopsia']

entities_list: @entity1829 :: ('MESH:D010211', 'Disease') :: ['papilledema']

entities_list: @entity5562 :: ('MESH:D015875', 'Disease') :: ['anisocoria']

entities_list: @entity2846 :: ('MESH:D020288', 'Disease') :: ['choroid plexus papilloma']

entities_list: @entity6447 :: ('MESH:D002524', 'Disease') :: ['right upper limb, and cerebellar ataxia']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['subtentorial ventricular diverticulum', 'Ventricular diverticulum']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['ependymal layers and cerebral parenchyma']

answer: @entity67 :: (MESH:D018754,Disease) :: ['subtentorial ventricular diverticulum']


abstract: Marked non-communicating @entity1276 may rarely cause @entity9009 producing either a dilated cystic cavity (ventricular diverticulum) or communication between ventricle system and subarachnoid space (spontaneous ventriculostomy). @entity67 has been believed to be collection of cerebrospinal fluid which escaped beneath the pia mater after rupture of @entity1779 . We proposed herein to report a case of @entity67 which accompanied with @entity2846 of the lateral ventricle. A nine year-old @entity1 admitted to our hospital complaining of clumsiness of hands and walking, disability of reading, @entity10 and @entity391 . The neurological examination revealed @entity5545 , @entity1829 , @entity5562 , @entity1805 , @entity425 of @entity6447 . CT brain scan showed a large high density area at the trigone of the left lateral ventricle with non-communicating @entity1276 and an extra-axial low density area in the posterior fossa. The medial space of the left trigone was especially ballooned and is just shifted above incisura tentoria by the @entity5 . The intraventricular @entity5 was totally removed by operation and proved to be benign @entity2846 microscopically. The subtentorial mass was confirmed to be a cyst contiguous to the medial trigone of the lateral ventricle, namely ventricular diverticulum. Three special features were recognized in this case. The first, this was the first example of @entity9009 accompanied with @entity5 in the lateral ventricle reviewing all reports of both ventricular diverticulum and spontaneous ventriculostomy. The second, this ventricular diverticulum was not produced merely by @entity1276 alone but mainly by direct effects of the @entity5 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A case of @entity67 accompanied with XXXX in the lateral ventricle].

answer: @entity2846 :: (MESH:D020288,Disease) :: ['choroid plexus papilloma']


abstract: We performed the longitudinal study in @entity1 with focal spikes about characteristic changes in @entity302 foci for periods of between one year and 5 years 9 months. The 116 @entity302 @entity1 were evaluated, ranging in onset age from 10 month to 12 year 9 month old (mean age: 6 year 11 month). They were subdivided into four groups according to their region of foci: group 1, 41 @entity1 with the centro-temporal spikes ( @entity3389 ); group 2, 14 @entity1 with the occipital spikes; group 3, 6 @entity1 with frontal pole spikes; group 4, 55 @entity1 with the other focal spikes. EEG examinations were followed 6 months interval in each @entity1 , and total 412 EEG trancing were investigated. Migration of @entity302 foci was recognized in thirty eight @entity1 (32.8%): 17 (41%) in @entity3389 , 7 (50%) in occipital spikes, 4 (67%) in frontal pole spikes and 10 (18%) in other spikes. The mean time to the migration of next foci was 45.6 months in @entity3389 , 18.4 months in occipital spikes, 17.6 months in frontal pole spike and 61.4 months in other spikes. As to the regions of migrated foci, @entity3389 tended to move to the near and horizontal areas such as from central to temporal. Whereas, occipital spikes and frontal pole spikes tended to move to the distant and vertical areas such as from occipital to frontal pole and from frontal pole to occipital. But other spikes showed no tendency.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Longitudinal study of XXXX foci in childhood].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'children']

entities_list: @entity3389 :: ('MESH:D019522', 'Disease') :: ['Rolandic discharges']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epileptic']


abstract: The cerebral blood flow velocities (CBFV) of @entity1 with perinatal @entity1763 and @entity2806 ( @entity2806 ) in the first 12 hours of their lives have been the chief focus of our concern in this study. @entity2806 which can develop in the earlier hours of @entity2806 , and the detection and diagnosis of this condition with color Doppler ultrasonography (cD-USG) will be put into discussion. Twenty-three full-term newborn @entity1 who had perinatal @entity1763 and @entity2806 together with a control group constituting twenty full-term newborn @entity1 who produced no problems, were included in our study. All of the @entity1 underwent cD-USG in the postpartum period of the first 12 hours (mean 8.4 hours). Measurements being based upon peak systolic velocity (PSV), end diastolic velocity (EDV) and Pouecelout's resistive index (RI) in anterior and middle cerebral arteries were conducted. The @entity1 , having been discharged from the unit they were followed up for mean 9.8 months in the outpatient clinic. PSV and EDV counts in the postpartum first 12 hours of 23 @entity1 who were detected to have @entity2806 were found to be significantly lower compared to the control group, whereas RI counts were found to be significantly higher (p < 0.05). The counts obtained from the right and left cerebral arteries of the @entity1 with @entity2806 were found to be corraleted with each others. The neonates in the @entity1 group were observed to have gone through this prognosis: Three of them died, three of them had @entity306 , one of them had @entity739 , and three of them had @entity851 . When we compared the CBFV of the 10 neonates who had poor prognosis, retrospectively with the other 13 neonates who had good prognosis, PSV and EDV were found to be significantly lower and RI significantly higher (p < 0.05). In the light of the data we have obtained, cD-USG can be considered to be a highly practical device in evaluating CBVF of the @entity1 with @entity2806 . A skillful detection of the decrease in cerebral blood flow which can develop in the postasphyxial first 12 hours and the prospective treatments being based upon this approach would contribute to the diagnosis, treatment and prognosis of such cases.

title: Clinical value of color Doppler ultrasonography measurements of full-term newborns with perinatal XXXX and @entity2806 in the first 12 hours of life and long-term prognosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'infants']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['developmental retardation']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['hypoxic ischemic encephalopathy', 'HIE', 'Cerebral ischemia']

entities_list: @entity739 :: ('MESH:D013036', 'Disease') :: ['infantile spasms']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']

answer: @entity1763 :: (MESH:D001237,Disease) :: ['asphyxia']


abstract: The cerebral blood flow velocities (CBFV) of @entity1 with perinatal @entity1763 and @entity2806 ( @entity2806 ) in the first 12 hours of their lives have been the chief focus of our concern in this study. @entity2806 which can develop in the earlier hours of @entity2806 , and the detection and diagnosis of this condition with color Doppler ultrasonography (cD-USG) will be put into discussion. Twenty-three full-term newborn @entity1 who had perinatal @entity1763 and @entity2806 together with a control group constituting twenty full-term newborn @entity1 who produced no problems, were included in our study. All of the @entity1 underwent cD-USG in the postpartum period of the first 12 hours (mean 8.4 hours). Measurements being based upon peak systolic velocity (PSV), end diastolic velocity (EDV) and Pouecelout's resistive index (RI) in anterior and middle cerebral arteries were conducted. The @entity1 , having been discharged from the unit they were followed up for mean 9.8 months in the outpatient clinic. PSV and EDV counts in the postpartum first 12 hours of 23 @entity1 who were detected to have @entity2806 were found to be significantly lower compared to the control group, whereas RI counts were found to be significantly higher (p < 0.05). The counts obtained from the right and left cerebral arteries of the @entity1 with @entity2806 were found to be corraleted with each others. The neonates in the @entity1 group were observed to have gone through this prognosis: Three of them died, three of them had @entity306 , one of them had @entity739 , and three of them had @entity851 . When we compared the CBFV of the 10 neonates who had poor prognosis, retrospectively with the other 13 neonates who had good prognosis, PSV and EDV were found to be significantly lower and RI significantly higher (p < 0.05). In the light of the data we have obtained, cD-USG can be considered to be a highly practical device in evaluating CBVF of the @entity1 with @entity2806 . A skillful detection of the decrease in cerebral blood flow which can develop in the postasphyxial first 12 hours and the prospective treatments being based upon this approach would contribute to the diagnosis, treatment and prognosis of such cases.

title: Clinical value of color Doppler ultrasonography measurements of full-term newborns with perinatal @entity1763 and XXXX in the first 12 hours of life and long-term prognosis.

answer: @entity2806 :: (MESH:D002545,Disease) :: ['hypoxic ischemic encephalopathy']


abstract: @entity2025 and II are diverse and quite frequent. After @entity281 , the virus establishes a life-long latency in the sensory ganglia and recrudescences may occur at an unpredictable rate. Recurrent @entity281 represent the majority of clinical manifestations of @entity2025 . Their management is currently well established using evidence-based medicine data. Primary @entity3305 is generally not treated with antivirals in otherwise healthy @entity1 , although intravenous @entity1033 may be offered in severe primary @entity281 , particularly in the immunocompromised @entity1 . The decision whether or not to treat recurrent @entity3305 should be evaluated individually and depends on the frequency and severity of relapses, the impairment of the quality of life, and the cost of therapy. @entity1 with mild disease may benefit from topical therapy, and those with severe and frequent recurrences may be considered for intermittent or long-term oral antiviral therapy. Primary @entity12881 is treated with oral or intravenous antivirals, depending on the severity of the @entity281 and associated symptoms. Recurrent @entity12881 can be managed with episodic short courses of oral antivirals in @entity1 whose recurrences are moderate to severe and rare, and have a clear prodrome. @entity1 with >5 episodes/year, severe recurrences or unrecognisable prodromes may be best managed with long-term suppressive antiviral prophylaxis. @entity778 is also responsible for a variety of other clinical manifestations, including herpetic @entity281 , disseminated and atypical @entity281 , @entity130 , @entity23923 , and @entity778 -associated @entity9374 . @entity2025 may also represent a complication following cosmetic procedures of the oro-facial region, surgical and dental interventions, sun exposure and burns. Precise treatment guidelines for these @entity2025 are not firmly established.

title: Treatment of mucocutaneous presentations of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient']

entities_list: @entity1033 :: ('MESH:D000212', 'Chemical') :: ['aciclovir']

entities_list: @entity12881 :: ('MESH:D006558', 'Disease') :: ['genital herpes']

entities_list: @entity23923 :: ('MESH:D007617', 'Disease') :: ['eczema herpeticum']

entities_list: @entity3305 :: ('MESH:D006560', 'Disease') :: ['labial herpes']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['cutaneous infections', 'infection', 'labial and genital herpes infections', 'infections', 'whitlow, neonatal infection', 'primary infection']

entities_list: @entity2025 :: ('MESH:D020031', 'Disease') :: ['HSV infections', 'HSV infection', 'Infections by herpes simplex virus (HSV) types I']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic herpes']

entities_list: @entity9374 :: ('MESH:D004892', 'Disease') :: ['erythema multiforme']

answer: @entity2025 :: (MESH:D020031,Disease) :: ['herpes simplex virus infections']


abstract: The @entity2858 @entity13608 (PR) has proved to be a good target for antiretroviral therapy of @entity791 , and various PR inhibitors are now in clinical use. However, there is a rapid selection of viral variants bearing mutations in the @entity13608 that are resistant to clinical inhibitors. Drug resistance also involves mutations of the nucleocapsid/p1 and p1/p6 cleavage sites of @entity5024 , both in vitro and in vivo. Cleavages at these sites have been shown to be rate limiting steps for polyprotein processing and viral maturation. Furthermore, these sites show significant sequence polymorphism, which also may have an impact on virion infectivity. We have studied the hydrolysis of oligopeptides representing these cleavage sites with representative mutations found as natural variations or that arise as resistant mutations. Wild-type and five drug resistant PRs with mutations within or outside the substrate binding site were tested. While the natural variations showed either increased or decreased susceptibility of peptides toward the proteinases, the resistant mutations always had a beneficial effect on catalytic efficiency. Comparison of the specificity changes obtained for the various substrates suggested that the maximization of the van der Waals contacts between substrate and @entity13608 is the major determinant of specificity: the same effect is crucial for inhibitor potency. The natural nucleocapsid/p1 and p1/p6 sites do not appear to be optimized for rapid hydrolysis. Hence, mutation of these rate limiting cleavage sites can partly compensate for the reduced catalytic activity of drug resistant mutant @entity2858 proteinases.

title: Effect of sequence polymorphism and drug resistance on two @entity2858 XXXX processing sites.

answer: @entity5024 :: (155030(Tax:11676),Gene) :: ['Gag']


abstract: The @entity2858 @entity13608 (PR) has proved to be a good target for antiretroviral therapy of @entity791 , and various PR inhibitors are now in clinical use. However, there is a rapid selection of viral variants bearing mutations in the @entity13608 that are resistant to clinical inhibitors. Drug resistance also involves mutations of the nucleocapsid/p1 and p1/p6 cleavage sites of @entity5024 , both in vitro and in vivo. Cleavages at these sites have been shown to be rate limiting steps for polyprotein processing and viral maturation. Furthermore, these sites show significant sequence polymorphism, which also may have an impact on virion infectivity. We have studied the hydrolysis of oligopeptides representing these cleavage sites with representative mutations found as natural variations or that arise as resistant mutations. Wild-type and five drug resistant PRs with mutations within or outside the substrate binding site were tested. While the natural variations showed either increased or decreased susceptibility of peptides toward the proteinases, the resistant mutations always had a beneficial effect on catalytic efficiency. Comparison of the specificity changes obtained for the various substrates suggested that the maximization of the van der Waals contacts between substrate and @entity13608 is the major determinant of specificity: the same effect is crucial for inhibitor potency. The natural nucleocapsid/p1 and p1/p6 sites do not appear to be optimized for rapid hydrolysis. Hence, mutation of these rate limiting cleavage sites can partly compensate for the reduced catalytic activity of drug resistant mutant @entity2858 proteinases.

title: Effect of sequence polymorphism and drug resistance on two XXXX @entity5024 processing sites.

answer: @entity2858 :: (11676,Species) :: ['HIV-1']


abstract: We assessed the value of bone marrow biopsy prospectively in a group of 91 individuals with @entity978 . The median age of our population was 29 years (range 4-87 years); 59 were males. Most @entity1 (45%) had nodular sclerosing disease and most @entity1 (44%) were in pathological stage II at diagnosis. The bone marrow biopsy showed infiltration by @entity978 in only three individuals (3.3%); two of these @entity1 displayed constitutional symptoms and had been assigned to stage III before the biopsy. In one case, bone marrow biopsy was the diagnostic procedure, which was performed as part of the investigation of fever of unknown origin. Follow-up periods ranged between 1 and 117 months (median 16 months). All @entity1 achieved complete remission, seven @entity1 relapsed and four were given autologous stem cell transplants. The median survival of the whole group was 117 months, while the 3500-day survival was 76%. As bone marrow biopsy was the diagnostic procedure in one case, bone marrow biopsy was a useful staging procedure in only 2.2% of @entity1 (two out of 90 @entity1 ). We suggest that bone marrow biopsy should be only be performed as a staging procedure in a selected subset of @entity1 with @entity978 (clinical stage III, B symptoms, etc.).

title: Role of bone marrow examination in staging XXXX : experience in M  xico.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's disease"]

answer: @entity978 :: (MESH:D006689,Disease) :: ['Hodgkin's disease']


abstract: OBJECTIVE: To determine the role of the cerebral cortex in neurally mediated @entity1163 , the electroencephalograms (EEG) of @entity1 recorded during head up tilt table test were analysed. DESIGN: Retrospective study. SETTING: University hospital. @entity1 : 18 @entity1 with @entity1163 or near @entity1163 underwent head up tilt table test with simultaneous ECG and EEG monitoring. METHODS: Standard 70 degrees tilt table test was done with simultaneous ECG and EEG monitoring. EEG waveforms were analysed by both visual inspection and spectral analysis. RESULTS: 6 of 18 @entity1 (33%) had a positive tilt table test. Before @entity1163 slow waves increased in @entity1 with a positive test. In addition, five of six tilt positive @entity1 (83%) had slow wave activity that lateralised to the left side of the brain (mean (SD) 822 (724) v 172 (215) micro V(2), p < 0.05), while none of the tilt negative @entity1 exhibited lateralisation (24 (15) v 26 (19) micro V(2), NS). Spectral analysis showed that the lateralisation occurred in the delta frequency. The lateralisation preceded the event by 5-56 seconds (18 (21) seconds). CONCLUSIONS: EEG activity lateralises to the left hemisphere of the brain before @entity1163 . The lateralisation precedes @entity1163 and is associated with the onset of @entity1168 , @entity551 , and clinical symptoms. These findings suggest that the central nervous system may have a role in neurally mediated @entity1163 .

title: New insights into the mechanism of neurally mediated XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

answer: @entity1163 :: (MESH:D013575,Disease) :: ['syncope']


abstract: @entity683 is a common @entity580 . Serious outbreaks occur typically in elderly long-term @entity1 , but have also been reported in renal, transplant and oncology units, neonatal intensive care and paediatrics. It is likely that staff- @entity1 @entity580 is common. Prompt diagnosis of an outbreak lies at the heart of an effective @entity683 control programme. This requires effective virological surveillance. There are a variety of strategies that can help to prevent spread of @entity683 in health care settings. @entity281 control should include @entity281 residents, restricting circulation of nursing staff between @entity1 , and restriction of visitors. Annual @entity683 immunization should be offered to elderly @entity1 , subjects with @entity102 , and those in long-term residential or nursing home care. Vaccination of health care workers has been shown to be effective in protecting elderly @entity1 in long-term care. Use of oral @entity7776 or @entity23216 is an additional possible strategy for prophylaxis or treatment during an outbreak.

title: Nosocomial transmission of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity23216 :: ('MESH:D012299', 'Chemical') :: ['rimantadine']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza', 'Influenza']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['isolating infected', 'Basic infection']

entities_list: @entity7776 :: ('MESH:D000547', 'Chemical') :: ['amantadine']

entities_list: @entity580 :: ('MESH:D003428', 'Disease') :: ['cross-infection', 'nosocomial infection']

answer: @entity683 :: (MESH:D007251,Disease) :: ['influenza']


abstract: We investigated the involvement of @entity1426 metabolites in basal and @entity10447 ( @entity1218 ) stimulated prolactin release by GH3 cells, a cloned strain of @entity35 @entity977 cells. GH3 cells spontaneously released 9 and 15 HETEs and the 15 HETE release was greater than that of 9 HETE. When the cells were challenged by 10(-5) M AA, they were able to produce 5, 9, 12 and 15 HETEs. 10(-6) M @entity1218 only stimulated the release of the two metabolites synthesized by the basal cells (15 and 9 HETEs). This release depended on the length of stimulation by @entity1218 . When both AA and @entity1218 were added, there was an increase in 15 and 9 HETE production. In all cases, more 15 HETE was released than other metabolites. In dose-response studies using @entity1218 concentrations of 10(-6) M to 10(-12) M, the highest level of 9 HETE release was obtained at 10(-11) M @entity1218 and the highest release of 15 HETE was at 10(-9) M @entity1218 . PRL secretion by GH3 cells challenged by @entity1218 showed the same pattern as 15 HETE release, and the correlation between PRL and 15 HETE was significant (p less than 0.001). These data indicate that 15 HETE is the lipoxygenase metabolite released in the largest amounts by GH3 cells and suggest some physiological interaction between 15 HETE and @entity1218 in the control of PRL secretion.

title: @entity1426 metabolism in a cloned strain of @entity35 XXXX cells: correlation between 15 hydroxyeicosatetraenoic acid release and the prolactin secretory process.

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity10447 :: ('25569(Tax:10116)', 'Gene') :: ['thyrotropin releasing hormone']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary tumor']

answer: @entity977 :: (MESH:D010911,Disease) :: ['pituitary tumor']


abstract: We investigated the involvement of @entity1426 metabolites in basal and @entity10447 ( @entity1218 ) stimulated prolactin release by GH3 cells, a cloned strain of @entity35 @entity977 cells. GH3 cells spontaneously released 9 and 15 HETEs and the 15 HETE release was greater than that of 9 HETE. When the cells were challenged by 10(-5) M AA, they were able to produce 5, 9, 12 and 15 HETEs. 10(-6) M @entity1218 only stimulated the release of the two metabolites synthesized by the basal cells (15 and 9 HETEs). This release depended on the length of stimulation by @entity1218 . When both AA and @entity1218 were added, there was an increase in 15 and 9 HETE production. In all cases, more 15 HETE was released than other metabolites. In dose-response studies using @entity1218 concentrations of 10(-6) M to 10(-12) M, the highest level of 9 HETE release was obtained at 10(-11) M @entity1218 and the highest release of 15 HETE was at 10(-9) M @entity1218 . PRL secretion by GH3 cells challenged by @entity1218 showed the same pattern as 15 HETE release, and the correlation between PRL and 15 HETE was significant (p less than 0.001). These data indicate that 15 HETE is the lipoxygenase metabolite released in the largest amounts by GH3 cells and suggest some physiological interaction between 15 HETE and @entity1218 in the control of PRL secretion.

title: XXXX metabolism in a cloned strain of @entity35 @entity977 cells: correlation between 15 hydroxyeicosatetraenoic acid release and the prolactin secretory process.

answer: @entity1426 :: (MESH:D016718,Chemical) :: ['Arachidonic acid']


abstract: We investigated the involvement of @entity1426 metabolites in basal and @entity10447 ( @entity1218 ) stimulated prolactin release by GH3 cells, a cloned strain of @entity35 @entity977 cells. GH3 cells spontaneously released 9 and 15 HETEs and the 15 HETE release was greater than that of 9 HETE. When the cells were challenged by 10(-5) M AA, they were able to produce 5, 9, 12 and 15 HETEs. 10(-6) M @entity1218 only stimulated the release of the two metabolites synthesized by the basal cells (15 and 9 HETEs). This release depended on the length of stimulation by @entity1218 . When both AA and @entity1218 were added, there was an increase in 15 and 9 HETE production. In all cases, more 15 HETE was released than other metabolites. In dose-response studies using @entity1218 concentrations of 10(-6) M to 10(-12) M, the highest level of 9 HETE release was obtained at 10(-11) M @entity1218 and the highest release of 15 HETE was at 10(-9) M @entity1218 . PRL secretion by GH3 cells challenged by @entity1218 showed the same pattern as 15 HETE release, and the correlation between PRL and 15 HETE was significant (p less than 0.001). These data indicate that 15 HETE is the lipoxygenase metabolite released in the largest amounts by GH3 cells and suggest some physiological interaction between 15 HETE and @entity1218 in the control of PRL secretion.

title: @entity1426 metabolism in a cloned strain of XXXX @entity977 cells: correlation between 15 hydroxyeicosatetraenoic acid release and the prolactin secretory process.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: AIM: The pathogenesis of traumatic @entity4 remains unclear. The generally held view is that @entity4 is caused primarily by @entity455 and that @entity4 plays a relatively minor role in the swelling process. The goal of this study was to examine the roles of cerebral blood volume (CBV) and @entity4 in traumatic @entity4 . @entity1 AND METHODS: Both brain-tissue water and CBV were measured in 76 head-injured @entity1 , and the relative contribution of @entity4 and blood to total @entity4 was determined. Comparable measures of brain-tissue water were obtained in 30 healthy volunteers and CBV in seven volunteers. Brain @entity4 was measured using magnetic resonance imaging, implementing a new technique for accurate measurement of total tissue water. Measurements of CBV in subgroup of 31 head-injured @entity1 were based on consecutive measures of cerebral blood flow (CBF) obtained using stable xenon and calculation of mean transit time by dynamic computerized tomography scanning after a rapid bolus injection of iodinated contrast material. RESULTS: The mean (+/- standard deviation) percentage of swelling due to water was 9.37 +/- 8.7%, whereas that due to blood was -0.8 +/- 1.32%. CONCLUSION: The results of this study showed that @entity2657 is the major fluid component contributing to traumatic @entity4 . Moreover, CBV is reduced in proportion to @entity551 following severe @entity1545 .

title: [ XXXX and changes of cerebral blood volume in @entity1 with head injuries].

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular engorgement']

entities_list: @entity2657 :: ('MESH:D001929', 'Disease') :: ['brain edema']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['edema', 'brain swelling']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['CBF reduction']

answer: @entity2657 :: (MESH:D001929,Disease) :: ['Cerebral edema']


abstract: AIM: The pathogenesis of traumatic @entity4 remains unclear. The generally held view is that @entity4 is caused primarily by @entity455 and that @entity4 plays a relatively minor role in the swelling process. The goal of this study was to examine the roles of cerebral blood volume (CBV) and @entity4 in traumatic @entity4 . @entity1 AND METHODS: Both brain-tissue water and CBV were measured in 76 head-injured @entity1 , and the relative contribution of @entity4 and blood to total @entity4 was determined. Comparable measures of brain-tissue water were obtained in 30 healthy volunteers and CBV in seven volunteers. Brain @entity4 was measured using magnetic resonance imaging, implementing a new technique for accurate measurement of total tissue water. Measurements of CBV in subgroup of 31 head-injured @entity1 were based on consecutive measures of cerebral blood flow (CBF) obtained using stable xenon and calculation of mean transit time by dynamic computerized tomography scanning after a rapid bolus injection of iodinated contrast material. RESULTS: The mean (+/- standard deviation) percentage of swelling due to water was 9.37 +/- 8.7%, whereas that due to blood was -0.8 +/- 1.32%. CONCLUSION: The results of this study showed that @entity2657 is the major fluid component contributing to traumatic @entity4 . Moreover, CBV is reduced in proportion to @entity551 following severe @entity1545 .

title: [ @entity2657 and changes of cerebral blood volume in XXXX with head injuries].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: During the nineteenth century, physicians either discovered or invented a variety of clinical autobiography called "traumatic memory." Freud produced two versions of this memory, the final version in the 1920s. A revolutionary nosology (DSM-III), adopted in 1980, promised to extirpate Freud and the concept of @entity11167 from American psychiatry. However, it made a tacit exception for Freud's concept of @entity130 , renaming it "postraumatic @entity66 ." The following decades have been a period of intense clinical and scientific interest in this disorder. An influential research program has investigated @entity130 and its brain through variations in @entity701 excretion. I describe the history of this program, and examine its distinctive knowledge product. its running narrative of its achievements. The narrative's structure is analyzed and found to resemble a crossword puzzle constructed from heterogenous kinds of inference, recalling The Interpretation of Dreams. My conclusion is that, far from extirpating Freud's @entity11167 , biological research has secured a place for it in today's post-Freudian psychiatry.

title: Our XXXX and its brain.

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['stress disorder']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic neurosis']

answer: @entity130 :: (MESH:D014947,Disease) :: ['traumatic neurosis']


abstract: 30 @entity6660 @entity1 from the andrologic outpatient service of the University-Hospital for Gynecology and Obstetrics, Graz, Austria, received a treatment with @entity4082 - @entity1792 . A doses of 25 mg daily was given for 25 days, followed by a break of 5 days. This treatment cycle was repeated three times, providing a total of 4 months of therapy. Rigid criteria of selection were applied for the @entity1 in this trial, pretreatment serum levels of FSH, LH, @entity251 , prolactin and @entity53 had to be in normal or low-normal range. After treatment FSH, LH and @entity251 were re-evaluated and a semen analysis was performed. Six to eight weeks afterwards another spermiogram was done. A significant raise of sperm density was observed immediately after treatment and at the control 6-8 weeks after therapy. Motility and morphologic quality remained unchanged after the therapeutic course. @entity948 content of seminal plasma raised significantly 6-8 weeks after therapy. FSH, LH and @entity251 increased also on a significant level. 6 pregnancies could be achieved, no negative side effects of treatment had to be registered.

title: [Results of low-dose treatment of XXXX with @entity4082 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity4082 :: ('MESH:D002996', 'Chemical') :: ['clomiphene']

entities_list: @entity948 :: ('MESH:D005632', 'Chemical') :: ['Fructose']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity6660 :: ('MESH:D009845', 'Disease') :: ['oligozoospermia']

answer: @entity6660 :: (MESH:D009845,Disease) :: ['oligozoospermia']


abstract: 30 @entity6660 @entity1 from the andrologic outpatient service of the University-Hospital for Gynecology and Obstetrics, Graz, Austria, received a treatment with @entity4082 - @entity1792 . A doses of 25 mg daily was given for 25 days, followed by a break of 5 days. This treatment cycle was repeated three times, providing a total of 4 months of therapy. Rigid criteria of selection were applied for the @entity1 in this trial, pretreatment serum levels of FSH, LH, @entity251 , prolactin and @entity53 had to be in normal or low-normal range. After treatment FSH, LH and @entity251 were re-evaluated and a semen analysis was performed. Six to eight weeks afterwards another spermiogram was done. A significant raise of sperm density was observed immediately after treatment and at the control 6-8 weeks after therapy. Motility and morphologic quality remained unchanged after the therapeutic course. @entity948 content of seminal plasma raised significantly 6-8 weeks after therapy. FSH, LH and @entity251 increased also on a significant level. 6 pregnancies could be achieved, no negative side effects of treatment had to be registered.

title: [Results of low-dose treatment of @entity6660 with XXXX ].

answer: @entity4082 :: (MESH:D002996,Chemical) :: ['clomiphene citrate']


abstract: We analysed case records of 2507 @entity1 with @entity1358 treated in the department of onco-urology of Cancer Research Center (Moscow). 1939 of them underwent nephrectomy between 1971 and 1999. The overall incidence of adrenal metastases according to CT and histological findings was 4.7%. Synchronous metastases occurred in 90 and metachronous ones in 30 @entity1 . Radical nephrectomy with adrenalectomy was performed in 18 out of 90 @entity1 with synchronous metastases, palliative nephrectomy in 20 and 52 @entity1 were not considered for surgery. Among 18 @entity1 who underwent complete surgical resection, 12(66%) had either lymph node involvement or distant metastases. A microscopic @entity3 was found on histological examination only in 1 @entity1 with normal CT scan and macroscopically intact adrenal on intraoperative assessment. Mean survival after radical nephrectomy with adrenalectomy in 6 @entity1 with solitary lesions was 57 months compared to the longest survival of 31 months in @entity1 with @entity66 . Solitary metachronous ipsilateral and contralateral adrenal involvement was present in 7 @entity1 . The average interval between nephrectomy and appearance of adrenal @entity3 in this group was 73 months. One @entity1 was lost for follow-up and one died of @entity774 4.3 months after adrenalectomy. One @entity1 underwent a consecutive removal of brain and lung metastases 33 and 38 months following adrenalectomy while the remaining 4 were alive in 15, 16, 26 and 34 months with no evidence of the disease. Thus, ipsilateral adrenalectomy is obligatory only in @entity1 with severe disease as shown by CT scan or at nephrectomy. About one-third of the @entity1 will benefit from the surgery. Adrenalectomy should be performed in case of obvious adrenal involvement. The aggressive surgical approach is justified in solitary metachronous adrenal involvement because of long-term survival expected in some of such @entity1 .

title: [Kidney cancer XXXX to the adrenal gland. Role of adrenalectomy].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['widespread disease']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity774 :: ('MESH:D000312', 'Disease') :: ['adrenal deficiency']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: The initial events in signal transduction in @entity2690 -secreting cells are summarized in FIGURE 8. Both nutrient stimuli, such as @entity413 and @entity1522 and the muscarinic agonist @entity5402 ( @entity5402 ) raise [ @entity141 ]i. Although the rise in [ @entity141 ]i precedes the stimulation of @entity2690 release, it is not a moment-to-moment regulator of release. The metabolizable fuel stimuli cause @entity141 influx through voltage-dependent @entity141 channels following depolarization of the membrane potential. In contrast, @entity5402 , which does not depolarize, elicits Ptd Ins 4,5-P2 hydrolysis, a reaction catalyzed by phospholipase C. The generation of Ins 1,4,5-P3 in this instance is @entity141 independent, but appears to involve a @entity15055 . However, this protein is not a substrate for pertussis toxin. The levels of Ins 1,4,5-P3, which releases @entity141 from an @entity855 -dependent @entity141 pool of the endoplasmic reticulum, are increased prior to the rise in [ @entity141 ]i. The mitochondria may take up @entity141 after large increases in [ @entity141 ]i. A previously proposed second messenger, @entity1426 , is much less selective than Ins 1,4,5-P3 in that it releases @entity141 from mitochondria as well as from the endoplasmic reticulum in a slow and irreversible manner. As Ins 1,4,5-P3 is also generated during @entity413 stimulation of islets, albeit in a @entity141 -dependent manner, this metabolite could mediate not only the action of @entity5402 but also contribute to amplifying the [ @entity141 ]i rise in response to @entity413 .

title: Signal transduction in XXXX secretion: comparison between fuel stimuli and receptor agonists.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity15055 :: ('8843', 'Gene') :: ['GTP-binding protein']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity5402 :: ('MESH:D002217', 'Chemical') :: ['carbachol', 'carbamylcholine']

answer: @entity2690 :: (3630,Gene) :: ['insulin']


abstract: @entity1 sperm at ejaculation are suspended in the seminal plasma, a heterogeneous mixture deriving from the testicular/epididymal fluid and from secretions of seminal vesicles, prostate and bulbourethral glands. Biochemical characteristics of seminal fluid change along the male reproductive tract when considering its inorganic and organic composition and pH but it is known that in each region of the male genital tract seminal osmolarity is higher than that of serum. It has been previously demonstrated that in invertebrate and vertebrate sperm, seminal plasma osmolarity influences sperm motility and activity, and @entity1 sperm have been shown to possess osmosensitive @entity460 entry pathway that controls important functions such as acrosome reaction and oocyte penetration. In the present study, we have determined seminal plasma osmolarity in a large number of normozoospermic fertile and asthenozoospermic infertile subjects correlating it with sperm motility percentages and kinematic characteristics determined utilizing a computerized motion analysis system. Our results confirm that seminal plasma osmolarity is higher than that of serum (336.1 +/- 20.2 vs. 291.1 +/- 6.9 @entity28842 /L, respectively). Normozoospermic subjects show seminal osmolarity values that are significantly lower with respect to asthenozoospermic @entity1 (317.8 +/- 12.2 vs. 345.2 +/- 22.6 @entity28842 /L, p<0.001), irrespective of the cause of @entity19474 . Seminal plasma osmolarity negatively correlates with sperm progressive motility percentages and kinetic characteristics (curvilinear velocity, linear velocity, linear coefficient and lateral displacements of sperm head). Furthermore, when sperm from fertile subjects were suspended in medium with an osmolarity increasing from 300 to 600 @entity28842 , sperm motility percentages and kinetics characteristics were progressively reduced and nearly abolished when medium osmolarity was 600 @entity28842 . On the contrary, when sperm from asthenozoospermic subjects with high semen osmolarity were resuspended in medium with lower osmolarity, sperm motility parameters improved significantly. Sperm motility parameters did not correlate with seminal plasma concentrations of @entity1372 , @entity972 , @entity2865 with a weak correlation only with seminal @entity460 concentration. No correlations are present between seminal plasma osmolarity and ionic composition. In conclusion, the present study confirms and extends the knowledge that, in @entity1 , seminal plasma osmolarity is higher than that of serum and demonstrates that seminal osmolarity influences sperm motility characteristics and then it may contribute to the pathogenesis of some forms of @entity19474 and @entity4810 .

title: Role of seminal osmolarity in the reduction of XXXX sperm motility.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'Mammalian']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity4810 :: ('MESH:D007248', 'Disease') :: ['male infertility']

entities_list: @entity19474 :: ('MESH:D053627', 'Disease') :: ['asthenozoospermia']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: @entity375 is an outstanding cellular model for metabolic studies in glycation. Due to its high glycolytic activity, it produces @entity14625 , a highly reactive intracellular glycation agent, at a rate of approx. 0.1% of the glycolytic flux. We investigated @entity14625 metabolism in @entity375 cells, using haploid null mutants. Growth studies showed that the most sensitive strains to @entity45768 were the null mutants for @entity66625 and @entity70941 , coding for @entity2041 synthase I and glyoxalase I respectively. The GRE3 null mutant, lacking @entity3650 reductase activity, is as sensitive as the control strain. Kinetic modelling and computer simulation of this type of experiment were also performed, and we concluded that the most important parameters for controlling the intracellular concentration of @entity14625 are the activity of glyoxalase I and the @entity2197 concentration. Moreover, our model predicts an intracellular steady-state concentration of @entity14625 of approx. 2 microM. Our results show that the glyoxalase pathway is the main detoxification pathway for @entity45768 in @entity375 , and is likely to be the key enzymatic anti-glycation agent in these cells.

title: Anti-glycation defences in XXXX .

entities_list: @entity14625 :: ('MESH:D011765', 'Chemical') :: ['methylglyoxal']

entities_list: @entity45768 :: ('CHEBI:27659', 'Chemical') :: ['2-oxoaldehydes']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity375 :: ('4932', 'Species') :: ['yeast', 'Saccharomyces cerevisiae']

answer: @entity375 :: (4932,Species) :: ['yeast']


abstract: PURPOSE: To compare the results of deep sclerectomy in @entity9998 ( @entity9998 ) with those in @entity725 ( @entity725 ). METHODS: This consecutive, prospective study comprised 24 @entity9998 @entity1 (28 eyes) and 25 @entity725 @entity1 (29 eyes) who underwent deep sclerectomy. Two different implants were used: either an absorbable collagen implant (Aqua-Flow) or a non-absorbable hydrophilic acrylic implant (T-Flux). The number of @entity726 medications, intraocular pressure (IOP) and complications were compared postoperatively. The definition of complete success was IOP below 19 mmHg without therapy. RESULTS: After a mean follow-up of 19.9 +/- 10.9 months (range 6-36 months) in the @entity9998 group and 16.2 +/- 10.0 months (range 6-36 months) in the @entity725 group, complete success was seen in 60.7% and in 37.9% of eyes, respectively (p=0.085). After adjustments for disparities in baseline characteristics, survival analysis demonstrated that success rates were better over time in @entity9998 eyes than in @entity725 eyes (p=0.038). At all time-points, except at 24 months, the IOP was lower in the @entity9998 group than in the @entity725 group. This difference was statistically significant at 1 week (p=0.050) and 3 months (p=0.006). At 18 months, the mean decrease in number of medications was 77.3% in the @entity9998 group and 65.9% in the @entity725 group (not statistically significant). Levelled @entity5891 occurred more frequently in @entity9998 eyes (35.7%) than in @entity725 eyes (13.8%). CONCLUSION: Capsular @entity726 @entity1 had significantly higher success rates over time than @entity725 @entity1 following deep sclerectomy with implant.

title: Deep sclerectomy in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity725 :: ('MESH:C562750', 'Disease') :: ['primary open-angle glaucoma', 'POAG']

entities_list: @entity9998 :: ('MESH:D017889', 'Disease') :: ['capsular glaucoma', 'CG']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

answer: @entity9998 :: (MESH:D017889,Disease) :: ['capsular glaucoma']


abstract: PURPOSE: To compare the results of deep sclerectomy in @entity9998 ( @entity9998 ) with those in @entity725 ( @entity725 ). METHODS: This consecutive, prospective study comprised 24 @entity9998 @entity1 (28 eyes) and 25 @entity725 @entity1 (29 eyes) who underwent deep sclerectomy. Two different implants were used: either an absorbable collagen implant (Aqua-Flow) or a non-absorbable hydrophilic acrylic implant (T-Flux). The number of @entity726 medications, intraocular pressure (IOP) and complications were compared postoperatively. The definition of complete success was IOP below 19 mmHg without therapy. RESULTS: After a mean follow-up of 19.9 +/- 10.9 months (range 6-36 months) in the @entity9998 group and 16.2 +/- 10.0 months (range 6-36 months) in the @entity725 group, complete success was seen in 60.7% and in 37.9% of eyes, respectively (p=0.085). After adjustments for disparities in baseline characteristics, survival analysis demonstrated that success rates were better over time in @entity9998 eyes than in @entity725 eyes (p=0.038). At all time-points, except at 24 months, the IOP was lower in the @entity9998 group than in the @entity725 group. This difference was statistically significant at 1 week (p=0.050) and 3 months (p=0.006). At 18 months, the mean decrease in number of medications was 77.3% in the @entity9998 group and 65.9% in the @entity725 group (not statistically significant). Levelled @entity5891 occurred more frequently in @entity9998 eyes (35.7%) than in @entity725 eyes (13.8%). CONCLUSION: Capsular @entity726 @entity1 had significantly higher success rates over time than @entity725 @entity1 following deep sclerectomy with implant.

title: Deep sclerectomy in XXXX with @entity9998 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: From July 1999 to July 2000, 40 @entity1 from the Surgical Oncology and Gastroenterology Departments of Irmandade da Santa @entity13389 de Miseric  rdia de Porto Alegre were enrolled in a prospective study in order to find the frequency of @entity1082 DNA (HPV-DNA) in @entity1721 . They were compared to 10 normal individuals (controls). Digene Inc. (Digene Corporation, Gaithersburg @entity601 , USA) Hybrid Capture II assay, a chemoluminescent method, was used in both groups. The samples were collected from the @entity5 group by endoscopic biopsy in 20 cases, and by surgical specimens in the other 20 cases; the control group all underwent endoscopic biopsies. The cut-off point in the analytical assay for HPV-DNA was 1.0 pg/mL. Digene Corp. Hybrid Capture II assay tests HPV-DNA and differentiates high and low-risk for malignization virus groups. Gender, age, location of the @entity5 in esophagus and degree of differentiation on histology were also analyzed. There was one positive case (1.14 pg/mL), a 2.5% frequency of low-risk HPV-DNA type in the @entity1721 group (CI 95%: 0.00-7.34%). This group of @entity1 consisted of 30 male and 10 female individuals, similar to the distribution seen in large series of such @entity1 from the Brazilian population. The mean age was 63 years. Endoscopic samples of 10 @entity1 who underwent endoscopic biopsy procedure for aleatory reasons, with normal looking esophageal mucosa, were tested to detect HPV-DNA, as controls. There was one positive case (1.17 pg/mL) of high-risk HPV-DNA type, resulting in a 10% positive rate. HPV-DNA is rarely found in @entity1721 : we found a 2.5% frequency, with confidence interval of 0-7.34%; and this is in the same range of controls (10% frequency, with CI: 9.1-10.9%). Both @entity1 had a viral load quite near the 1.0 pg/mL cut-off point.

title: Association between @entity1721 and XXXX detected by Hybrid Capture II assay.

entities_list: @entity1721 :: ('MESH:C562729', 'Disease') :: ['esophageal squamous cell carcinomas', 'esophageal squamous cell carcinoma']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus']

answer: @entity1082 :: (10566,Species) :: ['human papillomavirus']


abstract: From July 1999 to July 2000, 40 @entity1 from the Surgical Oncology and Gastroenterology Departments of Irmandade da Santa @entity13389 de Miseric  rdia de Porto Alegre were enrolled in a prospective study in order to find the frequency of @entity1082 DNA (HPV-DNA) in @entity1721 . They were compared to 10 normal individuals (controls). Digene Inc. (Digene Corporation, Gaithersburg @entity601 , USA) Hybrid Capture II assay, a chemoluminescent method, was used in both groups. The samples were collected from the @entity5 group by endoscopic biopsy in 20 cases, and by surgical specimens in the other 20 cases; the control group all underwent endoscopic biopsies. The cut-off point in the analytical assay for HPV-DNA was 1.0 pg/mL. Digene Corp. Hybrid Capture II assay tests HPV-DNA and differentiates high and low-risk for malignization virus groups. Gender, age, location of the @entity5 in esophagus and degree of differentiation on histology were also analyzed. There was one positive case (1.14 pg/mL), a 2.5% frequency of low-risk HPV-DNA type in the @entity1721 group (CI 95%: 0.00-7.34%). This group of @entity1 consisted of 30 male and 10 female individuals, similar to the distribution seen in large series of such @entity1 from the Brazilian population. The mean age was 63 years. Endoscopic samples of 10 @entity1 who underwent endoscopic biopsy procedure for aleatory reasons, with normal looking esophageal mucosa, were tested to detect HPV-DNA, as controls. There was one positive case (1.17 pg/mL) of high-risk HPV-DNA type, resulting in a 10% positive rate. HPV-DNA is rarely found in @entity1721 : we found a 2.5% frequency, with confidence interval of 0-7.34%; and this is in the same range of controls (10% frequency, with CI: 9.1-10.9%). Both @entity1 had a viral load quite near the 1.0 pg/mL cut-off point.

title: Association between XXXX and @entity1082 detected by Hybrid Capture II assay.

answer: @entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous cell carcinoma']