abstract: High density lipoprotein (HDL) @entity165 and the HDL/total @entity165 ratio have been measured in 440 @entity1 with coronary, cerebral or @entity1095 and in 440 matched controls. The @entity1 were subdivided into sex- and age-groups and according to physical activity, smoking, @entity101 and @entity2175 . The average HDL @entity165 level was significantly decreased in all the three groups of localization of @entity455 ( @entity455 ). Plasma HDL concentration in @entity1 was lower than in @entity1 in every age-group. Lowest values were measured in @entity1 with @entity455 . From among the risk factors supposed to be related to @entity455 , lack of physical exercise resulted in a decrease of HDL @entity165 and HDL/total @entity165 values. In all the three localizations of @entity455 cigarette smokers had lower HDL levels than non-smokers. The influence of @entity101 on serum HDL concentration was not unidirectional. The coexistence of @entity2175 resulted in decreased lipid parameters. The sera of insulin-dependent @entity6 had higher HDL contents and higher HDL/total @entity165 ratios than those of non- @entity6 in all the three localizations of the @entity455 in @entity1 and in @entity1 suffering from @entity1095 .

title: Plasma high density lipoproteins in coronary, cerebral and XXXX . The influence of various risk factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1095 :: ('MESH:D016491', 'Disease') :: ['peripheral vascular disease']

entities_list: @entity2175 :: ('MESH:D003924', 'Disease') :: ['non-insulin-dependent and insulin-dependent diabetes mellitus', 'non-insulin-dependent diabetes and IVD']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['cerebral vascular diseases', 'ischaemic vascular disease', 'IVD', 'vascular disease']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1095 :: (MESH:D016491,Disease) :: ['peripheral vascular disease']


abstract: OBJECTIVES: To investigate the association of carotid @entity729 (CAC) on panoramic radiographs and determine carotid artery @entity731 with ultrasonography. STUDY DESIGN: The study included 4050 subjects aged 50 years and older. Panoramic radiographs for the presence of CAC were interpreted. @entity2998 ( @entity2998 ), @entity3538 ( @entity3538 ), carotid plaques, and the diameter of the common carotid artery (CCA-diameter) were measured by using ultrasonography. RESULTS: @entity3538 was significantly greater in male subjects with CAC than in those without CAC. CCA-diameter was significantly greater in subjects with CAC than in those without CAC in both genders. However, there was no significant difference in @entity2998 . CAC was associated with carotid plaque (for @entity1 , odds ratio [OR] 2.14; 95% confidence interval [CI] 1.01-3.36; for @entity1 , OR 1.19; 95% CI 0.84-1.67). CONCLUSION: CAC on panoramic radiographs was positively associated with IMT and plaque in @entity1 and positively associated with carotid diameter in both sexes. CAC on panoramic radiographs was positively associated with @entity2998 .

title: The correlation of carotid XXXX on panoramic radiographs and determination of carotid artery @entity731 with ultrasonography.

entities_list: @entity3538 :: ('MESH:D002341', 'Disease') :: ['CB-IMT', 'carotid bulb IMT']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['Common carotid artery intima-media thickness', 'carotid atherosclerosis', 'CCA-IMT']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['artery calcification']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

answer: @entity729 :: (MESH:D061205,Disease) :: ['artery calcification']


abstract: OBJECTIVES: To investigate the association of carotid @entity729 (CAC) on panoramic radiographs and determine carotid artery @entity731 with ultrasonography. STUDY DESIGN: The study included 4050 subjects aged 50 years and older. Panoramic radiographs for the presence of CAC were interpreted. @entity2998 ( @entity2998 ), @entity3538 ( @entity3538 ), carotid plaques, and the diameter of the common carotid artery (CCA-diameter) were measured by using ultrasonography. RESULTS: @entity3538 was significantly greater in male subjects with CAC than in those without CAC. CCA-diameter was significantly greater in subjects with CAC than in those without CAC in both genders. However, there was no significant difference in @entity2998 . CAC was associated with carotid plaque (for @entity1 , odds ratio [OR] 2.14; 95% confidence interval [CI] 1.01-3.36; for @entity1 , OR 1.19; 95% CI 0.84-1.67). CONCLUSION: CAC on panoramic radiographs was positively associated with IMT and plaque in @entity1 and positively associated with carotid diameter in both sexes. CAC on panoramic radiographs was positively associated with @entity2998 .

title: The correlation of carotid @entity729 on panoramic radiographs and determination of carotid artery XXXX with ultrasonography.

answer: @entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']


abstract: OBJECTIVE: To evaluate the safety and efficacy of @entity898 (NAC) orally on digital microcirculation blood flow in @entity1 with @entity2407 ( @entity2407 ) secondary to @entity785 ( @entity785 ). METHODS: This was a randomized, double-blind, placebo-controlled trial in which 42 @entity1 with @entity785 received oral NAC at a dose of 600mg tid (21 @entity1 , mean age 45.6  9.5 years) or placebo (21 @entity1 , mean age 45.0  12.7 years) for four weeks. The primary endpoint was the change in cutaneous microcirculation blood flow before and after cold stimulation measured by laser Doppler imaging (LDI) at weeks 0 and 4. The frequency and severity of @entity2407 and the number of digital @entity1066 were also measured at weeks 0 and 4. The adverse events were recorded in the fourth week. RESULTS: There was no significant change in digital blood flow assessed by LDI before or after cold stimulus after four weeks of NAC or placebo. Both groups showed significant improvement in the frequency and severity of @entity2407 attacks, with no difference between the two groups. At the end of the study, the placebo group had three digital @entity1066 , while the NAC group showed no @entity1066 . NAC was well tolerated and no @entity1 discontinued the treatment. CONCLUSIONS: NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands' microcirculation after four weeks of treatment in @entity1 with @entity2407 secondary to @entity785 .

title: [Oral @entity898 in the treatment of XXXX secondary to @entity785 : a randomized, double-blind, placebo-controlled clinical trial].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity898 :: ('MESH:D000111', 'Chemical') :: ['N-acetylcysteine']

entities_list: @entity2407 :: ('MESH:D011928', 'Disease') :: ["Raynaud's phenomenon", 'RP']

entities_list: @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic sclerosis', 'SSc']

answer: @entity2407 :: (MESH:D011928,Disease) :: ['Raynaud's phenomenon']


abstract: OBJECTIVE: To evaluate the safety and efficacy of @entity898 (NAC) orally on digital microcirculation blood flow in @entity1 with @entity2407 ( @entity2407 ) secondary to @entity785 ( @entity785 ). METHODS: This was a randomized, double-blind, placebo-controlled trial in which 42 @entity1 with @entity785 received oral NAC at a dose of 600mg tid (21 @entity1 , mean age 45.6  9.5 years) or placebo (21 @entity1 , mean age 45.0  12.7 years) for four weeks. The primary endpoint was the change in cutaneous microcirculation blood flow before and after cold stimulation measured by laser Doppler imaging (LDI) at weeks 0 and 4. The frequency and severity of @entity2407 and the number of digital @entity1066 were also measured at weeks 0 and 4. The adverse events were recorded in the fourth week. RESULTS: There was no significant change in digital blood flow assessed by LDI before or after cold stimulus after four weeks of NAC or placebo. Both groups showed significant improvement in the frequency and severity of @entity2407 attacks, with no difference between the two groups. At the end of the study, the placebo group had three digital @entity1066 , while the NAC group showed no @entity1066 . NAC was well tolerated and no @entity1 discontinued the treatment. CONCLUSIONS: NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands' microcirculation after four weeks of treatment in @entity1 with @entity2407 secondary to @entity785 .

title: [Oral @entity898 in the treatment of @entity2407 secondary to XXXX : a randomized, double-blind, placebo-controlled clinical trial].

answer: @entity785 :: (MESH:D012595,Disease) :: ['systemic sclerosis']


abstract: OBJECTIVE: To evaluate the safety and efficacy of @entity898 (NAC) orally on digital microcirculation blood flow in @entity1 with @entity2407 ( @entity2407 ) secondary to @entity785 ( @entity785 ). METHODS: This was a randomized, double-blind, placebo-controlled trial in which 42 @entity1 with @entity785 received oral NAC at a dose of 600mg tid (21 @entity1 , mean age 45.6  9.5 years) or placebo (21 @entity1 , mean age 45.0  12.7 years) for four weeks. The primary endpoint was the change in cutaneous microcirculation blood flow before and after cold stimulation measured by laser Doppler imaging (LDI) at weeks 0 and 4. The frequency and severity of @entity2407 and the number of digital @entity1066 were also measured at weeks 0 and 4. The adverse events were recorded in the fourth week. RESULTS: There was no significant change in digital blood flow assessed by LDI before or after cold stimulus after four weeks of NAC or placebo. Both groups showed significant improvement in the frequency and severity of @entity2407 attacks, with no difference between the two groups. At the end of the study, the placebo group had three digital @entity1066 , while the NAC group showed no @entity1066 . NAC was well tolerated and no @entity1 discontinued the treatment. CONCLUSIONS: NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands' microcirculation after four weeks of treatment in @entity1 with @entity2407 secondary to @entity785 .

title: [Oral XXXX in the treatment of @entity2407 secondary to @entity785 : a randomized, double-blind, placebo-controlled clinical trial].

answer: @entity898 :: (MESH:D000111,Chemical) :: ['N-acetylcysteine']


abstract: AIM: To investigate the effect of @entity439 repair (EVAR) on platelet (PLT) function and reveal possible associated factors. METHODS: Fifty consecutive @entity1 were included. PLT count and activation ( @entity8729 - @entity4210 ), white blood cell (WBC) count, and high sensitivity @entity1851 (hs-CRP) were measured preoperatively, at the first and third postoperative day. RESULTS: EVAR elicited a significant reduction in PLT count from baseline to first day after EVAR (p   <   0.001), while no significant difference was noted between the first and third day. Furthermore, @entity8729 expression was markedly elevated at the first day after EVAR (median % positive PLTs from 13.7 at baseline to 22.1, p   =   0.05), but returned to baseline levels by the third day. Maximum @entity1028 diameter was the only factor that significantly affected the @entity8729 values (p   =   0.005). Postoperative @entity4210 values were significantly correlated with total @entity439 volume (p   =   0.05) and were higher in endografts made from @entity2635 (p   =   0.01). There were no correlation between PLT activation and hs-CRP, WBC, maximum temperature, and 30-day morbidity. CONCLUSION: EVAR has elucidated a significant reduction in PLT count and increase in PLT activation at the immediate postoperative period. The type of the endograft material and the @entity439 maximum diameter and volume appear to play an important role in PLT activation.

title: Platelet activation after endovascular repair of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['endovascular aneurysm', 'aneurysm']

entities_list: @entity2635 :: ('CHEBI:60160', 'Chemical') :: ['polyester']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']


abstract: INTRODUCTION: Risk scores have been developed for allogeneic hematopoietic cell transplantation (HCT) outcomes, such as the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) and the modified European Group for Blood and Marrow Transplantation risk score (mEBMT) for @entity3052 . We investigated the influence of these scores for 350 @entity1 who underwent transplantation for @entity3052 ( @entity3052 ). @entity1 AND METHODS: The HCT-CI scores were grouped as 0 to 2 and  >=  3 (231 and 119 @entity1 , respectively) and the mEBMT scores as 0 to 2 and  >=  3 (166 and 184 @entity1 , respectively). RESULTS: Univariate analysis showed a significant association between the HCT-CI score and @entity1349 ( @entity1349 ) (P  = .01), as did the mEBMT score (P  = .002). The 5-year @entity1349 rate was 50% and 34% for a mEBMT score of 0 to 2 and  >=  3, respectively. A subgroup of @entity1 with a mEBMT score of 0 to 1 (n  = 32) demonstrated a favorable @entity1349 of 75% at 5 years. This subgroup was younger (median age, 31 years), in first remission at transplantation, and had related donors. For the HCT-CI, the 5-year @entity1349 was 46% and 34% for a score of 0 to 2 and  >=  3, respectively. @entity1 with an HCT-CI score of 0 (n  = 94) had a 5-year @entity1349 of 44%. Multivariable analysis confirmed both the HCT-CI score and the mEBMT score, as previously grouped, as independent prognostic variables for both @entity1349 (P  = .02 and P  = .001, respectively) and nonrelapse mortality (NRM) (P  = .01 and P  = .003, respectively). CONCLUSION: The results of the present study have demonstrated that the HCT-CI and mEBMT are both prognostic for @entity1349 and NRM in our cohort. However, the mEBMT score can identify a favorable-risk subgroup of @entity1 not identifiable using the HCT-CI.

title: Modified EBMT Pretransplant Risk Score Can Identify Favorable-risk @entity1 Undergoing Allogeneic Hematopoietic Cell Transplantation for XXXX , Not Identified by the HCT-CI Score.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML', 'acute leukemia']

answer: @entity3052 :: (MESH:D015470,Disease) :: ['AML']


abstract: INTRODUCTION: Risk scores have been developed for allogeneic hematopoietic cell transplantation (HCT) outcomes, such as the Hematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) and the modified European Group for Blood and Marrow Transplantation risk score (mEBMT) for @entity3052 . We investigated the influence of these scores for 350 @entity1 who underwent transplantation for @entity3052 ( @entity3052 ). @entity1 AND METHODS: The HCT-CI scores were grouped as 0 to 2 and  >=  3 (231 and 119 @entity1 , respectively) and the mEBMT scores as 0 to 2 and  >=  3 (166 and 184 @entity1 , respectively). RESULTS: Univariate analysis showed a significant association between the HCT-CI score and @entity1349 ( @entity1349 ) (P  = .01), as did the mEBMT score (P  = .002). The 5-year @entity1349 rate was 50% and 34% for a mEBMT score of 0 to 2 and  >=  3, respectively. A subgroup of @entity1 with a mEBMT score of 0 to 1 (n  = 32) demonstrated a favorable @entity1349 of 75% at 5 years. This subgroup was younger (median age, 31 years), in first remission at transplantation, and had related donors. For the HCT-CI, the 5-year @entity1349 was 46% and 34% for a score of 0 to 2 and  >=  3, respectively. @entity1 with an HCT-CI score of 0 (n  = 94) had a 5-year @entity1349 of 44%. Multivariable analysis confirmed both the HCT-CI score and the mEBMT score, as previously grouped, as independent prognostic variables for both @entity1349 (P  = .02 and P  = .001, respectively) and nonrelapse mortality (NRM) (P  = .01 and P  = .003, respectively). CONCLUSION: The results of the present study have demonstrated that the HCT-CI and mEBMT are both prognostic for @entity1349 and NRM in our cohort. However, the mEBMT score can identify a favorable-risk subgroup of @entity1 not identifiable using the HCT-CI.

title: Modified EBMT Pretransplant Risk Score Can Identify Favorable-risk XXXX Undergoing Allogeneic Hematopoietic Cell Transplantation for @entity3052 , Not Identified by the HCT-CI Score.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: Flooding and drought affect @entity1460 growth because @entity1460 is a stress-sensitive crop. In 2-day-old plants exposed to 2-day flooding or drought, the fresh weight of roots was markedly suppressed, although the root morphology clearly differed between two conditions. To understand the response mechanisms of @entity1460 to flooding and drought stresses, a gel-free proteomic technique was used. A total of 97 and 48 proteins were significantly changed in response to flooding and drought stresses, respectively. Proteins involved in protein synthesis were decreased by flooding stress and increased by drought. Glycolysis-related proteins were increased in roots by both flooding and drought stresses. Fermentation, stress, and cell wall-related proteins were increased in response to flooding stress, whereas cell organization and redox-related proteins were increased under drought stress. Among the identified proteins, three @entity7726 synthetases were commonly decreased and increased in response to flooding and drought stresses, respectively. The mRNA expression levels of @entity7726 synthetase genes displayed a similar tendency to the changes in protein abundance. These results suggest that @entity7726 synthetase is involved in the regulation of stress response because it was changed in response to flooding and drought stresses. BIOLOGICAL SIGNIFICANCE: This study reported on the response mechanisms of @entity1460 to flooding and drought stresses using the gel-free proteomic technique. Proteins involved in protein synthesis were decreased by flooding stress and increased by drought. Glycolysis-related proteins were increased in roots by both flooding and drought stresses. Fermentation, stress, and cell wall-related proteins were increased in response to flooding stress, whereas cell organization and redox-related proteins were increased under drought stress. Among the identified proteins, three @entity7726 synthetases were commonly decreased and increased in response to flooding and drought stresses, respectively. The mRNA expression levels of @entity7726 synthetase genes displayed a similar tendency to the changes in protein abundance. These results suggest that @entity7726 synthetase is involved in the regulation of stress response because it was changed in response to flooding and drought stresses.

title: Characterization of proteins in XXXX roots under flooding and drought stresses.

entities_list: @entity7726 :: ('MESH:D012436', 'Chemical') :: ['S-adenosylmethionine']

answer: @entity1460 :: (3847,Species) :: ['soybean']


abstract: UNASSIGNED: To examine safety and efficacy of bandage soft contact lenses (BSCLs) for ocular chronic @entity2132 ( @entity2132 ), we conducted a phase II clinical trial. Extended-wear BSCLs were applied under daily topical antibiotic prophylaxis. @entity1 completed standardized symptom questionnaires at enrollment and at 2  weeks, 4  weeks, and 3  months afterward. Ophthalmologic assessment was performed at enrollment, at 2  weeks, and afterward as medically needed. Assessments at follow-up were compared with baseline by paired t-test. Nineteen @entity1 with ocular @entity2132 who remained symptomatic despite conventional treatments were studied. The mean Lee eye subscale score was 75.4 at enrollment and improved significantly to 63.2 at 2  weeks (P  =  .01), to 61.8 at 4  weeks (P  =  .005), and to 56.3 at 3  months (P  =  .02). The ocular surface disease index score and 11-point eye symptom ratings also improved significantly. According to the Lee eye subscale, clinically meaningful improvement was observed in 9 @entity1 (47%) at 2  weeks, in 11 @entity1 (58%) at 4  weeks, and in 9 @entity1 (47%) at 3  months. Visual acuity improved significantly at 2  weeks compared with enrollment values. Based on slit lamp exam at 2  weeks, punctate epithelial erosions improved in 58% of the @entity1 , showed stability in 16%, and worsened in 5%. No corneal ulceration or @entity5517 occurred. BSCLs are a widely available, safe, and effective treatment option that improves manifestations of ocular @entity2132 in approximately 50% of @entity1 . This study was registered at www.clinicaltrials.gov as NCT01616056.

title: Bandage Soft Contact Lenses for Ocular XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5517 :: ('MESH:D015817', 'Disease') :: ['ocular infection']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'graft-versus host disease']

answer: @entity2132 :: (MESH:D006086,Disease) :: ['Graft-versus-Host Disease']


abstract: In a retrospective study, the clinical course of 23 adult @entity1 with documented idiopathic @entity8 was reviewed. These @entity1 included 16 @entity1 and 7 @entity1 , who were followed for a period of as long as 9 years, 22 @entity1 (95.7%) were @entity1985 ( @entity644 of 3 g or more in 24 h) and 6 (26%) were @entity101 . 5 @entity1 were treated with @entity229 alone, 12 with @entity229 and @entity786 , 2 with @entity229 and @entity500 and 4 received no treatment. 18 @entity1 achieved complete remission (78.3%). 16 of these (88.9%) were treated with @entity229 , or @entity229 and @entity786 or @entity500 , and the remaining remitted spontaneously. In 3 additional @entity1 , @entity644 improved with treatment with @entity229 and immunosuppression but remained in the @entity1985 range in 2, and fell to 1.8 g/day in 1. @entity1 who failed to respond to @entity230 showed remarkable improvement when therapy with @entity786 was added. Of the 4 @entity1 not treated, 2 underwent spontaneous remission and 2 developed @entity177 . These results suggest a beneficial effect of @entity230 in the treatment of @entity8 , and suggests further that @entity786 may be effective in @entity1 not responding to @entity230 alone. Finally, these results suggest that in many @entity1 therapy may have to be prolonged before a remission can be observed.

title: XXXX : response to @entity230 and immunosuppression.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['membranous nephropathy']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic']

answer: @entity8 :: (MESH:D007674,Disease) :: ['Membranous nephropathy']


abstract: In a retrospective study, the clinical course of 23 adult @entity1 with documented idiopathic @entity8 was reviewed. These @entity1 included 16 @entity1 and 7 @entity1 , who were followed for a period of as long as 9 years, 22 @entity1 (95.7%) were @entity1985 ( @entity644 of 3 g or more in 24 h) and 6 (26%) were @entity101 . 5 @entity1 were treated with @entity229 alone, 12 with @entity229 and @entity786 , 2 with @entity229 and @entity500 and 4 received no treatment. 18 @entity1 achieved complete remission (78.3%). 16 of these (88.9%) were treated with @entity229 , or @entity229 and @entity786 or @entity500 , and the remaining remitted spontaneously. In 3 additional @entity1 , @entity644 improved with treatment with @entity229 and immunosuppression but remained in the @entity1985 range in 2, and fell to 1.8 g/day in 1. @entity1 who failed to respond to @entity230 showed remarkable improvement when therapy with @entity786 was added. Of the 4 @entity1 not treated, 2 underwent spontaneous remission and 2 developed @entity177 . These results suggest a beneficial effect of @entity230 in the treatment of @entity8 , and suggests further that @entity786 may be effective in @entity1 not responding to @entity230 alone. Finally, these results suggest that in many @entity1 therapy may have to be prolonged before a remission can be observed.

title: @entity8 : response to XXXX and immunosuppression.

answer: @entity230 :: (MESH:D013256,Chemical) :: ['steroids']


abstract: BACKGROUND: In the recently reported international survey of centers performing per-oral endoscopic myotomy (POEM), 88% of operators reported obtaining routinely an early postoperative contrast esophagram. To date, there have been no studies to assess the prognostic value of early esophagram in POEM. METHODS: A retrospective review of a prospectively maintained, single-institution database of @entity1 who underwent POEM for treatment of @entity1318 was conducted. @entity1 were evaluated with a routine contrast esophagram on the first postoperative day ( @entity773 ) to assess for perforation. The finding of delayed esophageal emptying, as determined by an attending radiologist, was compared with the @entity1 ' symptomatic outcomes and functional parameters at one year follow-up. RESULTS: Contrast esophagram was obtained on @entity773 for 72 @entity1 undergoing POEM; 26 @entity1 (36%) were observed to have a delay in esophageal emptying. Both groups of @entity1 , those with a delay and those without a delay in esophageal emptying on @entity773 , had similar preoperative Eckardt scores (7      2 vs 7      2, P = ns) and column height at 5  minutes on preoperative timed barium esophagram (12.1      8  cm vs 14.1      8  cm, P  =  ns). At a mean follow-up of 1  year, there was no difference in Eckardt scores between @entity1 with and those without a delay in emptying on @entity773 esophagram (1      2 vs 1      1, P = ns), nor was there a difference between the 2 groups in column height at 5  minutes on TBE (5.5      5  cm for delay vs 4.2      4  cm for no delay; P = ns). Rates of treatment failure, as measured by Eckardt score >3 or need for subsequent treatment, also did not differ between the 2 groups (3 @entity1 with delay vs 4 @entity1 without delay in emptying, P = ns). CONCLUSION: Delay in passage of contrast on @entity773 esophagram did not predict symptomatic or physiologic outcomes at 1-year follow-up in @entity1 undergoing POEM for treatment of @entity1318 .

title: Early esophagram in per-oral endoscopic myotomy (POEM) for XXXX does not predict long-term outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia']

answer: @entity1318 :: (MESH:D004931,Disease) :: ['achalasia']


abstract: UNASSIGNED: Current models of @entity2548 ( @entity2548 ) are @entity1707 models of femoral vein terminolaterally anastomosed to femoral artery, creating a deep @entity2548 . This feature sets it aside from @entity1 AVFs using superficial veins. Our @entity2548 model uses @entity742 superficial veins to create an @entity2548 almost identical to @entity1 model. AVFs were created in six @entity742 using basilic veins sutured terminolaterally to brachial artery. Presurgery vein and artery diameters were measured. We measured AVFs and feeding arteries blood flows and diameters at 1, 3, and 5  weeks postsurgery. At 5  weeks we performed angiograms, euthanized animals, and harvested AVFs. Four animals completed the study. Three AVFs developed and were patent at 5  weeks; one thrombosed. Animal weight and presurgery vessels diameters predicted AVFs blood flows and diameters. Despite using vessels with diameters smaller than the ones recommended for @entity1 @entity2548 , the Fistulas developed. Two animals died before the study conclusion for causes unrelated to surgery. This @entity2548 model is anatomically almost identical to the @entity1 @entity2548 and has a good maturation rate. It is a viable model for studying @entity2548 maturation, devices intended to improve @entity2548 maturation, @entity2548 related procedures and can even support hemodialysis needles.

title: XXXX Model of Hemodialysis Arteriovenous Fistula Using Superficial Veins.

entities_list: @entity2548 :: ('MESH:D001164', 'Disease') :: ['animal arteriovenous fistula', 'AVF']

answer: @entity742 :: (9940,Species) :: ['Sheep']


abstract: BACKGROUND: @entity195 is characterized by @entity73 , senile plaques of b-amyloid (Ab) peptides, neurofibrillary tangles composed of hyperphosphorylated    proteins and @entity528 . Ab and    are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are @entity563 - @entity1889 protein kinases activated by phosphorylation and involved in @entity528 . METHODS: In this study, Western blots, enzyme-linked immunosorbent assay and histological approaches were used to assess the concentrations of Ab,    and @entity4675 isoforms in postmortem brain tissue samples (10 @entity195 and 10 control) and in CSF samples from 30 living @entity1 with @entity195 and 27 controls with @entity16 excluding @entity195 . @entity1 with @entity195 were followed for 1-3 years and assessed using Mini-Mental State Examination scores. RESULTS: The biochemical and morphological results showed a significant increase of @entity35368 and phosphorylated @entity4675 levels in @entity1 with @entity195 , and @entity35368 levels correlated with Ab42 levels. Confocal microscopy revealed that @entity35368 was associated with Ab in senile plaques. The @entity35368 levels in the CSF were significantly elevated in @entity1 with @entity195 and correlated statistically with the rate of @entity73 in a mixed linear model. LIMITATIONS: The study involved different samples grouped into 3 small cohorts. Evaluation of @entity35368 in CSF was possible only with immunoblot analysis. CONCLUSION: We found that @entity35368 levels are increased in brain tissue and CSF from @entity1 with @entity195 . The finding that increased @entity35368 levels in CSF could reflect the rate of @entity73 is new and merits further investigation.

title: Increased levels of cerebrospinal fluid XXXX associated with amyloid pathology: links to @entity73 .

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic disease']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['Alzheimer disease']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

entities_list: @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal death', 'neuronal loss']

answer: @entity35368 :: (5602,Gene) :: ['JNK3']


abstract: BACKGROUND: @entity195 is characterized by @entity73 , senile plaques of b-amyloid (Ab) peptides, neurofibrillary tangles composed of hyperphosphorylated    proteins and @entity528 . Ab and    are useful markers in the cerebrospinal fluid (CSF). C-Jun N-terminal kinases (JNKs) are @entity563 - @entity1889 protein kinases activated by phosphorylation and involved in @entity528 . METHODS: In this study, Western blots, enzyme-linked immunosorbent assay and histological approaches were used to assess the concentrations of Ab,    and @entity4675 isoforms in postmortem brain tissue samples (10 @entity195 and 10 control) and in CSF samples from 30 living @entity1 with @entity195 and 27 controls with @entity16 excluding @entity195 . @entity1 with @entity195 were followed for 1-3 years and assessed using Mini-Mental State Examination scores. RESULTS: The biochemical and morphological results showed a significant increase of @entity35368 and phosphorylated @entity4675 levels in @entity1 with @entity195 , and @entity35368 levels correlated with Ab42 levels. Confocal microscopy revealed that @entity35368 was associated with Ab in senile plaques. The @entity35368 levels in the CSF were significantly elevated in @entity1 with @entity195 and correlated statistically with the rate of @entity73 in a mixed linear model. LIMITATIONS: The study involved different samples grouped into 3 small cohorts. Evaluation of @entity35368 in CSF was possible only with immunoblot analysis. CONCLUSION: We found that @entity35368 levels are increased in brain tissue and CSF from @entity1 with @entity195 . The finding that increased @entity35368 levels in CSF could reflect the rate of @entity73 is new and merits further investigation.

title: Increased levels of cerebrospinal fluid @entity35368 associated with amyloid pathology: links to XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive decline']


abstract: Ten @entity1 with unilateral @entity3541 had been treated by @entity6256 in the years 1971-1979. The proximal part of the facial nerve inside the petrous bone and at the inner ear entrance had been destroyed by @entity5 or accident without chance for repair. Therefore the hypoglossal nerve had been used to contact the intact main tunk and its intact peripheral nerve and mimic muscle system. 3 to 4 epineural nerve sutures had been placed with 8/0 vicryl suture material for approximation. In one @entity1 @entity254 could be obtained by splitting the hypoglossal nerve with remarkable result to the mimic function, while the muscular @entity194 of the tongue was minimal. With regard to the results the achieved mimic reinnervation took place in 3,5 to 5 months, but was found to be refined up to 2 years. Oral discomfort, swallowing, and @entity8408 lasted 2 1/2 to 6 weeks postoperatively, depending upon the age and the @entity1 mental activity, since the @entity1 has to learn by using his tongue for mimical expressions. The final result obtained a balanced closure of the mouth and eyes, a complete movement of the lips and cheeks, a rarely delayed innervation of the frontal muscles. Due to reinnervation the denervated half of the tongue had developed a marked increase of activity from nerve fiber ingrowth of the intact side. The @entity1 finally feels little to complain about the favourable facial result.

title: [ XXXX for rehabilitation of the paralyzed face (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6256 :: ('MESH:D020437', 'Disease') :: ['hypoglossal-facial nerve approximation']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity8408 :: ('MESH:D013064', 'Disease') :: ['speech disorders']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial nerve paralysis']

answer: @entity6256 :: (MESH:D020437,Disease) :: ['Hypoglossal-facial nerve cross-over']


abstract: UNASSIGNED: To analyze the glycosylation of anti- @entity9500 , we investigated purified IgG from healthy @entity1 , @entity1 with @entity12009 , and asymptomatic adult carriers of antiphospholipid antibodies. We observed that in the sera of healthy @entity1 and of @entity1 with @entity12009 , @entity3172 and IgG2 were predominant, respectively. The potentially protective anti- @entity9500 -IgM was lower in the sera of healthy children. Although anti- @entity9500 -associated @entity6300 did not differ between @entity1 and patients with @entity1701 , the associated C3c was significantly higher in the sera of healthy @entity1 . This indicates a more efficient clearance of anti- @entity9500 immune complexes in the healthy @entity1 . This clearance is not accompanied by @entity32 or coagulatory events. It is likely that the most important pathogenic factor of the anti- @entity9500 -IgG is related to the different glycosylation observed in healthy and diseased individuals. We detected a significantly higher sialylation of anti- @entity9500 -IgG isolated from the sera of healthy @entity1 and asymptomatic adults when compared with that of @entity1 with clinically apparent @entity1701 . Low sialylated IgG reportedly ameliorates @entity32 and @entity32 promotes hyposialylation. Thus, both reactions create a vicious circle that precipitates the pathology of the @entity1701 including thrombus-formation. We conclude that the increased sialylation of anti- @entity9500 -IgG of sera of healthy individuals limits their pathogenicity.

title: The Pathogenicity of Anti- XXXX -IgG Autoantibodies Depends on Fc Glycosylation.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1701 :: ('MESH:D016736', 'Disease') :: ['antiphospholipid syndrome']

answer: @entity9500 :: (350,Gene) :: ['b2GP1']


abstract: BACKGROUND AND OBJECTIVES: Although @entity7867 is usually associated with ear problems, it may also originate outside the ear. We therefore assessed the clinical characteristics of @entity1 with @entity7867 . SUBJECTS AND METHODS: We analyzed 294 @entity1 who presented with @entity7867 . We assessed differences in @entity7867 between adults and @entity1 , differences in otogenic vs. @entity7867 between adults and @entity1 , differences between @entity1 and @entity1 . RESULTS: Of the 294 @entity1 , 208 (70.7%) had @entity7867 and 86 (29.3%) had @entity7867 . Hearing disturbance and @entity2972 were significantly more common in @entity7867 , whereas @entity5254 , sore throat, and postnasal drip were significantly more common in @entity7867 . @entity1 were more likely to have @entity7867 than adults. The proportion of @entity1 with @entity7867 was significantly higher in adults than in @entity1 (p<0.05). @entity7867 was more common in @entity1 , whereas @entity7867 was more common in @entity1 . Among @entity1 with @entity7867 , @entity9 was significantly more frequent in @entity1 than in @entity1 (p<0.05). CONCLUSIONS: @entity7867 was more frequent in @entity1 than in @entity1 and in @entity1 than in adults, whereas @entity7867 was more frequent in @entity1 and adults, indicating that types of @entity7867 were dependent on age and gender.

title: Clinical Differences in Types of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'patients', 'Children', 'men']

entities_list: @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea']

entities_list: @entity7867 :: ('MESH:D004433', 'Disease') :: ['Otogenic otalgia', 'referred otalgia', 'otalgia', 'otogenic otalgia']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuralgia']

answer: @entity7867 :: (MESH:D004433,Disease) :: ['Otalgia']


abstract: Research suggests that adverse events in childhood, such as childhood physical, @entity458 , confer risk for later sexual assault. Psychological distress, coping strategies, and @entity146 may help explain the path from childhood abuse to revictimization. The present study explored how the use of sex to regulate negative affect (SRNA) operates independently, and in combination with other psychosocial factors to increase college @entity1 's (N=541) risk of experiencing prospective adult sexual assault (ASA). Sequential multiple mediator models in Mplus were used to assess the effect of three different forms of childhood abuse on prospective ASA, both independently and while controlling for other forms of childhood abuse. The indirect effect of adolescent sexual assault (AdolSA), @entity308 , SRNA, and @entity1 ' response to a sex-related vignette was tested using bias-corrected bootstrapping. In the full path model, @entity734 and AdolSA predicted ASA, while childhood physical and @entity458 were directly associated with AdolSA, but not @entity1281 . Additionally, @entity308 and @entity1 ' estimate of their likely behavior in a sex-related vignette directly predicted prospective ASA. Results using bootstrapping revealed that a history of childhood abuse predicted prospective ASA via diverse direct and indirect paths, as well as through a similar multiple mediator path. Overall, findings suggest that a combination of affective, coping, and sexual expectancy factors contribute to risk for revictimization in adult survivors of childhood abuse. Future research directions and targets for risk-reduction programming are discussed.

title: Pathways from childhood abuse to prospective revictimization: XXXX , sex to reduce negative affect, and forecasted @entity146 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['sexual behavior']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual abuse', 'sexual, and emotional abuse']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['childhood emotional abuse']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: Research suggests that adverse events in childhood, such as childhood physical, @entity458 , confer risk for later sexual assault. Psychological distress, coping strategies, and @entity146 may help explain the path from childhood abuse to revictimization. The present study explored how the use of sex to regulate negative affect (SRNA) operates independently, and in combination with other psychosocial factors to increase college @entity1 's (N=541) risk of experiencing prospective adult sexual assault (ASA). Sequential multiple mediator models in Mplus were used to assess the effect of three different forms of childhood abuse on prospective ASA, both independently and while controlling for other forms of childhood abuse. The indirect effect of adolescent sexual assault (AdolSA), @entity308 , SRNA, and @entity1 ' response to a sex-related vignette was tested using bias-corrected bootstrapping. In the full path model, @entity734 and AdolSA predicted ASA, while childhood physical and @entity458 were directly associated with AdolSA, but not @entity1281 . Additionally, @entity308 and @entity1 ' estimate of their likely behavior in a sex-related vignette directly predicted prospective ASA. Results using bootstrapping revealed that a history of childhood abuse predicted prospective ASA via diverse direct and indirect paths, as well as through a similar multiple mediator path. Overall, findings suggest that a combination of affective, coping, and sexual expectancy factors contribute to risk for revictimization in adult survivors of childhood abuse. Future research directions and targets for risk-reduction programming are discussed.

title: Pathways from childhood abuse to prospective revictimization: @entity308 , sex to reduce negative affect, and forecasted XXXX .

answer: @entity146 :: (MESH:D001523,Disease) :: ['sexual behavior']


abstract: UNASSIGNED: Cytotoxin K (CytK) produced by @entity5259 s.l. has generally been considered to be associated with the @entity6766 . Two distinct variants of CytK have been reported: CytK-1 from @entity71810 and CytK-2 from @entity5259 . In order to determine whether CytK plays a significant role in the @entity66 , the occurrence of cytK genes was assessed among 390 @entity5259 isolates with different origins including clinical and @entity6766 samples and was found to be 46%. Interestingly, the cytK occurrence was slightly lower in @entity6766 and clinical isolates than in environmental samples. Seventy cytK-2 positive strains (including 28 isolates from foodborne outbreaks) were then selected in order to assess their genetic diversity. A genetic dendrogram based on the cytK-2 sequences of these 70 strains and on two cytK-1 sequences from strains NVH 391-98 and 883-00 showed an important diversity. However, no strain clustering according to the origin or source of isolation was observed. These observations were confirmed by Multi-Locus Sequences Typing (MLST) based on five different loci of housekeeping genes (ccpA, recF, sucC, purF and gdpD) for which no grouping of foodborne outbreak strains could be identified. Therefore, the choice of cytK as virulence factor for the diarrhoeal pathotype does not seem to be relevant per se, even though the involvement of CytK in the @entity751 cannot be fully excluded. Potential synergistic effects between CytK and other virulence factors, together with their potential variable expression levels should be further investigated.

title: Is Cytotoxin K from XXXX a bona fide enterotoxin?

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['diarrhoeal disease']

entities_list: @entity6766 :: ('MESH:D005517', 'Disease') :: ['foodborne diarrhoeal syndrome', 'food poisoning']

entities_list: @entity71810 :: ('580165', 'Species') :: ['Bacillus cytotoxicus']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['diarrhoeal syndrome']

entities_list: @entity5259 :: ('1396', 'Species') :: ['B. cereus', 'Bacillus cereus']

answer: @entity5259 :: (1396,Species) :: ['Bacillus cereus']


abstract: BACKGROUND: The epidemiology of @entity483 ( @entity483 ) in the U.S.A. has been described largely via US population-based questionnaire studies. However, the validity of the questions used for self- and caregiver-reported @entity484 has not been previously demonstrated. OBJECTIVES: To validate the assessment of self- and caregiver-reported @entity484 . METHODS: We performed a prospective multicentre dermatology-practice-based study (three sites) to determine the validity of caregiver- and self-reported ever having @entity484 and 1-year history of @entity484 . Questionnaires were administered to unselected @entity1 prior to their encounter. @entity1 (n = 782) were then evaluated by expert dermatologists trained in utilizing the Hanifin and Rajka criteria for @entity483 . Sensitivity, specificity, positive predictive value ( @entity2286 ) and negative predictive value were determined. RESULTS: Caregiver-reported 1-year history of childhood @entity484 was found to have a sensitivity (95% confidence interval) of 0  70 (0  59-0  80), specificity of 0  96 (0  93-0  99) and @entity2286 of 0  87 (0  78-0  96) when compared with a physician's diagnosis of @entity483 at that visit. Similarly, self-reported 1-year history of adult @entity484 was found to have a sensitivity of 0  70 (0  59-0  80), specificity of 0  95 (0  93-0  97) and @entity2286 of 0  76 (0  64-0  85). The specificities and PPVs of a history of ever having caregiver- (0  89, 0  82-0  96 and 0  81, 0  70-0  93) and self-reported @entity484 (0  97, 0  95-0  99 and 0  91, 0  85-0  97) were high, with a high sensitivity in @entity1 (0  83, 0  72-0  95) but not in adults (0  43, 0  37-0  51). CONCLUSIONS: Self- and caregiver-reported diagnosis of @entity484 ever or in the past year based on a single question demonstrates sufficient validity for the epidemiological study of @entity483 .

title: Assessment of XXXX using self-report and caregiver report: a multicentre validation study.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis', 'AD']

answer: @entity483 :: (MESH:D003876,Disease) :: ['atopic dermatitis']


abstract: PURPOSE: To investigate the clinical feasibility and treatment outcomes of image-based @entity1168 ( @entity1168 ) brachytherapy using an intracavitary multichannel vaginal cylinder for the definitive treatment of @entity5 . METHODS AND MATERIALS: A total of 41 @entity1 with @entity5 (24% primary vaginal and 76% recurrence from other gynecologic primaries) treated with definitive radiotherapy    chemotherapy including image-based @entity1168 brachytherapy with a multichannel vaginal cylinder were included in the study. Image-based brachytherapy was completed using either CT- (41%) or MR-based planning (59%) with each fraction. The high-risk clinical target volume was defined based on the pre- and postexternal beam radiotherapy gross @entity5 volume. Doses were converted to equivalent dose of 2Gy per fraction. Endpoints examined were dose-volume parameters and early clinical outcomes. RESULTS: The median high-risk clinical target volume was 24.2cc (interquartile range [IQR], 12.6), with a median dose to 90% (D90) of 77.1Gy (IQR, 3.4). The median dose to 2cc (D2 cc) for the bladder, rectum, and sigmoid were 59.4Gy (IQR, 5.6), 58.2Gy (IQR, 4.1), and 52.3Gy (IQR, 5.5), respectively. After a median followup of 16 months (range, 3-35), complete clinical response was documented in 98% of the @entity1 . The 2-year local, regional, and distant control; and disease-free and overall survival were 93%, 100%, 81%, 78%, and 88%, respectively. The 2-year actuarial rate of late Grade 3 or higher @entity137 was 4% overall with 0%, 0%, 0%, and 4% for vaginal, bladder, urethral, and gastrointestinal, respectively. CONCLUSIONS: Image-based @entity1168 brachytherapy using an intracavitary multichannel cylinder seems feasible in @entity5 treatment. The described clinical implementation shows promising early clinical outcomes with high rates of local control and @entity137 , which should be validated with extended followup.

title: Image-based multichannel vaginal cylinder brachytherapy for XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['vaginal cancer', 'tumor', 'vaginal cancers', 'definitive vaginal cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'little toxicity']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['HDR', 'high-dose-rate']

answer: @entity5 :: (MESH:D009369,Disease) :: ['vaginal  cancer']


abstract: BACKGROUND: The prevalence of @entity28 in the United States continues to increase. Attention has recently turned to an emerging population of extremely overweight @entity1 , termed superobese and defined as those with body mass index (BMI) >= 50  kg/m(2). The goal of this study was to use a national database to evaluate postoperative complication rates after @entity348 ( @entity348 ) in superobese @entity1 and to compare @entity1 of different BMI classes. METHODS: @entity1 who underwent @entity348 or reverse @entity348 were identified in the PearlDiver database by International Classification of Diseases, Ninth Revision (ICD-9) codes. These @entity1 were then divided into nonobese, @entity28 , and superobese cohorts by ICD-9 codes. @entity260 were assessed and compared between cohorts. RESULTS: From 2005 to 2012, 144,239 unique @entity1 who underwent @entity348 or reverse @entity348 were identified, including 105,661 nonobese @entity1 , 23,864 @entity28 @entity1 , 13,759 morbidly @entity28 @entity1 , and 955 superobese @entity1 . Superobese @entity1 had a significantly higher rate of @entity281 , dislocation, component loosening, revision shoulder arthroplasty, @entity1211 , and medical complications after shoulder arthroplasty compared with nonobese controls. CONCLUSIONS: Obesity is associated with significantly increased rates of numerous complications after @entity348 , including @entity281 , dislocation, component loosening, revision surgery, @entity1211 , and medical complications, compared with nonobese controls. Superobesity (BMI  > 50  kg/m(2)) is associated with significantly increased rates of several complications compared with even @entity28 and morbidly @entity28 @entity1 , including @entity1211 , and medical complications.

title: Superobesity (body mass index >50  kg/m(2)) and  complications after XXXX : an incremental effect of increasing  body mass index.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese, morbidly obese', 'obese', 'obesity']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative complications']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['total shoulder arthroplasty', 'TSA']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['infection, component loosening, venous thromboembolism', 'venous thromboembolism']

answer: @entity348 :: (MESH:C535338,Disease) :: ['total shoulder arthroplasty']


abstract: BACKGROUND: Despite oversized latissimus dorsi free flap reconstruction in the head and neck area, esthetic and functional problems continue to exist due to the well-known occurrence of transplant shrinkage. The purpose of this study was to acquire an estimation of the volume and time of the shrinkage process. MATERIALS AND METHODS: The assessment of @entity393 was performed using a 3D evaluation of two postoperative CT scans. A retrospective review was conducted on all latissimus dorsi free flap reconstructions performed between 2004 and 2013. Inclusion criteria for the assessment were: resection of an @entity1697 and microsurgical defect coverage with latissimus dorsi free flap; a first postoperative CT ( @entity7487 ) performed between 3 weeks and a maximum of 3 months after reconstruction surgery; and an additional CT scan ( @entity18246 ) performed at least one year postoperatively. The exclusion criterion was surgical intervention in the local area between the acquisition of @entity7487 and @entity18246 . The effect of adjuvant radiation therapy was considered. Volume determination of the transplant was carried out in @entity7487 and @entity18246 by manual segmentation of the graft. RESULTS: Fifteen @entity1 were recruited. 3D evaluation showed an average @entity393 of 34.4%. In the consideration of postoperative radiotherapy the volume reduction was 39.2% in @entity1 with radiotherapy and 31.3% in @entity1 without radiotherapy. CONCLUSION: The reconstruction flap volume required for overcorrection of the surgical defect was investigated. This study indicates that a @entity393 of more than 30% could be expected one or more years after latissimus dorsi free flap reconstruction. Clinical trial number DRKS00007534.

title: Microvascular transplants in head and neck reconstruction: 3D evaluation of XXXX .

entities_list: @entity1697 :: ('MESH:D009062', 'Disease') :: ['oral carcinoma']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['volume loss']

answer: @entity393 :: (MESH:D034381,Disease) :: ['volume loss']


abstract: STUDY OBJECTIVE: To evaluate the degree of @entity158 relief provided by laparoscopic surgical treatment of @entity43 . DESIGN: Retrospective analysis DESIGN: Classification: II-2 SETTING: Academic Hospital and affiliated outpatient offices @entity1 : A total of 54 @entity1 from 2004 to 2008 who underwent surgical treatment for suspected @entity43 or @entity43 . INTERVENTION: Oophorectomy MEASUREMENTS AND MAIN RESULTS: Preoperative and @entity282 scores were recorded from @entity1 who underwent surgical treatment for either @entity43 . Data regarding co-morbid diagnoses that would contribute to chronic @entity158 (CPP), previous surgical history, surgical complications and pathology to confirm the preoperative diagnosis were also collected. Pathology confirmed that ovarian tissue was removed in 52 of the 54 @entity1 . 40% and 41% of @entity1 with @entity43 , respectively, achieved a 50% reduction of their average @entity158 levels; 50% and 56%, respectively, achieved a 30% reduction in average @entity158 levels. There was not a statistically significant difference in @entity282 relief between the two groups. Cases with @entity43 had more prior surgical procedures (4.8 vs. 3.6, p=.049) and were more likely to have a surgical complication (25% vs. 3%, p=.03) than cases with @entity43 . @entity1 with a 30% or greater decrease in their @entity158 levels postoperatively were likely to have fewer other diagnoses associated with @entity1118 (1.4 + 1.1 vs. 2.1 + 0.9; p=.009). CONCLUSION: Surgical treatment for @entity43 is effective, but is most effective in @entity1 with no other @entity158 -related diagnoses. Thus it is important to thoroughly evaluate @entity1 with @entity43 for other @entity2371 . In almost all cases surgery can be done laparoscopically in @entity1 with these syndromes.

title: The Efficacy of Laparoscopic Surgical Treatment of Ovarian XXXX .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian retention syndrome', 'ovarian remnant and ovarian retention syndromes', 'ovarian remnant syndrome', 'ovarian remnant or ovarian retention syndrome', 'ovarian remnant and ovarian retention']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'PATIENTS']

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain related disorders']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['abdominopelvic pain', 'pain']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity43 :: (MESH:D010051,Disease) :: ['Remnant and Ovarian Retention Syndromes']


abstract: INTRODUCTION: @entity733 associated with @entity1778 are rare. Most reported cases of @entity4558 abscesses occur after chemotherapy and are related to the immunosuppressive effects of the chemotherapy. Their etiology is most frequently fungal. PRESENTATION OF CASE: A 58-year-old male presented with @entity381 and @entity4 secondary to a multibacterial @entity733 which required a splenectomy. Upon investigation he was found to suffer from @entity1860 ( @entity1860 ) and @entity3892 . DISCUSSION: @entity733 are rarely found in @entity1778 @entity1 . Reported cases are fungal and commonly occur after chemotherapy due to immunosuppression. @entity4 with concurrent @entity381 can be found in other pathologies including @entity3377 , @entity3001 and even non-Hodgkin primary @entity706 . @entity4 in our case was likely secondary to @entity3892 and exacerbated by the effects of @entity381 upon the systemic circulation promoting @entity450 . CONCLUSION: This case illustrated an unusual presentation of @entity1860 because the @entity1 presented with @entity381 , a multibacterial @entity733 , and @entity4 .

title: Case report of rare chronic myelogenous leukemia related multibacterial XXXX presenting with @entity4 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3001 :: ('MESH:D008193', 'Disease') :: ['Lyme disease']

entities_list: @entity3377 :: ('MESH:D002006', 'Disease') :: ['brucellosis']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['testicular lymphoma']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['Scrotal swelling', 'scrotal swelling']

entities_list: @entity3892 :: ('MESH:D004823', 'Disease') :: ['epididymitis']

entities_list: @entity450 :: ('MESH:D006940', 'Disease') :: ['venous congestion']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia', 'leukemic']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity733 :: ('MESH:D000038', 'Disease') :: ['splenic abscess', 'Splenic abscesses']

entities_list: @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML', 'chronic myeloid leukemia']

answer: @entity733 :: (MESH:D000038,Disease) :: ['splenic abscess']


abstract: INTRODUCTION: @entity733 associated with @entity1778 are rare. Most reported cases of @entity4558 abscesses occur after chemotherapy and are related to the immunosuppressive effects of the chemotherapy. Their etiology is most frequently fungal. PRESENTATION OF CASE: A 58-year-old male presented with @entity381 and @entity4 secondary to a multibacterial @entity733 which required a splenectomy. Upon investigation he was found to suffer from @entity1860 ( @entity1860 ) and @entity3892 . DISCUSSION: @entity733 are rarely found in @entity1778 @entity1 . Reported cases are fungal and commonly occur after chemotherapy due to immunosuppression. @entity4 with concurrent @entity381 can be found in other pathologies including @entity3377 , @entity3001 and even non-Hodgkin primary @entity706 . @entity4 in our case was likely secondary to @entity3892 and exacerbated by the effects of @entity381 upon the systemic circulation promoting @entity450 . CONCLUSION: This case illustrated an unusual presentation of @entity1860 because the @entity1 presented with @entity381 , a multibacterial @entity733 , and @entity4 .

title: Case report of rare chronic myelogenous leukemia related multibacterial @entity733 presenting with XXXX .

answer: @entity4 :: (MESH:D004487,Disease) :: ['scrotal swelling']


abstract: BACKGROUND: More than two fifths of the world's population cook with solid fuels and are exposed to household air pollution (HAP). As of now, no studies have assessed whether switching to alternative fuels like biogas could impact cardiovascular health among cooks previously exposed to solid fuel use. METHODS: We conducted a propensity score matched cross-sectional study to explore if the sustained use of biogas fuel for at least ten years impacts blood pressure among adult female cooks of rural Nepal. We recruited one primary cook >= 30 years of age from each biogas (219 cooks) and firewood (300 cooks) using household and measured their systolic ( @entity13519 ) and diastolic blood pressure (DBP). Household characteristics, kitchen ventilation and 24-h kitchen @entity1223 were assessed. We matched cooks by age, body mass index and socio-economic status score using propensity scores and investigated the effect of biogas use through multivariate regression models in two age groups, 30-50 years and >50 years to account for any post-menopausal changes. RESULTS: We found substantially reduced 24-h kitchen @entity1223 levels among biogas-using households. After matching and adjustment for smoking, kitchen characteristics, ventilation status and additional fuel use, the use of biogas was associated with 9.8mmHg lower @entity13519 [95% confidence interval (CI), -20.4 to 0.8] and 6.5mmHg lower DBP (95% CI, -12.2 to -0.8) compared to firewood users among @entity1 >50 years of age. In this age group, biogas use was also associated with 68% reduced odds [Odds ratio 0.32 (95% CI, 0.14 to 0.71)] of developing @entity101 . These effects, however, were not identified in younger @entity1 aged 30-50 years. CONCLUSIONS: Sustained use of biogas for cooking may protect against @entity65 by lowering the risk of @entity101 , especially DBP, among older female cooks. These findings need to be confirmed in longitudinal or experimental studies.

title: Sustained use of biogas fuel and blood pressure among XXXX in rural Nepal.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['high blood pressure', 'hypertension']

entities_list: @entity1223 :: ('MESH:D002248', 'Chemical') :: ['carbon monoxide']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: The anaerobic biotransformation of @entity4965 ( @entity4966 ) can be affected by competing electron acceptors such as @entity596 . This study assessed the role of @entity596 reduction on the bioenhanced dissolution of @entity4966 dense non-aqueous phase liquid (DNAPL). Columns were set up as 1-D diffusion cells consisting of a lower DNAPL layer, a layer with an aquifer substratum and an upper water layer that is regularly refreshed. The substrata used were either inert sand or sand coated with 2-line @entity61248 (HFO) or two environmental @entity596 containing samples. The columns were inoculated with @entity56744 and were repeatedly fed with @entity5189 . In none of the diffusion cells, @entity7398 or @entity1786 was detected while dissolved and extractable @entity8798 increased strongly during 60d of incubation. The cis-DCE concentration peaked at 4.0cm from the DNAPL (inert sand) while it was at 3.4cm (sand+HFO), 1.7cm and 2.5cm (environmental samples). The @entity4966 concentration gradients near the DNAPL indicate that the DNAPL dissolution rate was larger than that in an abiotic cell by factors 1.3 (inert sand), 1.0 (sand+HFO) and 2.2 (both environmental samples). This results show that high bioavailable @entity596 in HFO reduces the @entity4966 degradation by competitive @entity596 reduction, yielding lower bioenhanced dissolution. However, @entity596 reduction in environmental samples was not reducing @entity4966 degradation and the dissolution factor was even larger than that of inert sand. It is speculated that physical factors, e.g. micro-niches in the environmental samples protect microorganisms from toxic concentrations of @entity4966 .

title: Bioenhanced dissolution of dense non-aqueous phase of XXXX as affected by iron reducing conditions: Model systems and environmental samples.

entities_list: @entity7398 :: ('MESH:D014752', 'Chemical') :: ['vinyl chloride']

entities_list: @entity61248 :: ('MESH:C092844', 'Chemical') :: ['ferrihydrite']

entities_list: @entity4965 :: ('MESH:D014241', 'Chemical') :: ['trichloroethylene']

answer: @entity4965 :: (MESH:D014241,Chemical) :: ['trichloroethylene']


abstract: Large @entity3727 emissions were observed from intertidal sediments in a coastal estuary, @entity739 Harbor, MA, USA. Average @entity3727 emission rates from 41 chambers during summer 2008 were 10.7mol N2Om(-2)h(-1)  4.43 mol N2Om(-2)h(-1) (standard error). Emissions were highest from sediments within a known wastewater plume, where a maximum @entity3727 emission rate was 155 mol N2Om(-2)h(-1). Intertidal @entity3727 fluxes were positively related to porewater ammonium concentrations at 10 and 25cm depths. In groundwater from 7 shoreline wells, dissolved @entity3727 ranged from 488% of saturation (56nM @entity3727 ) to more than 13000% of saturation (1529nM @entity3727 ) and was positively related to @entity1507 concentrations. Fresh and brackish porewater underlying 14 chambers was also supersaturated in @entity3727 , ranging from 2980% to 13175% of saturation. These observations support a relationship between anthropogenic nutrient loading and @entity3727 emissions in @entity739 Harbor, with both groundwater sources and also local @entity3727 production within nutrient-rich, intertidal sediments in the groundwater seepage face. @entity3727 emissions from intertidal "hotspot" in this harbor, together with estimated surface water emissions, constituted 2.4% of the average overall rate of @entity1568 export from the watershed to the estuary. This suggests that @entity3727 emissions factors from coastal ecosystems may be underestimated. Since anthropogenic nutrient loading affects estuaries worldwide, quantification of @entity3727 dynamics is warranted in other anthropogenically-impacted coastal ecosystems.

title: Substantial nitrous oxide emissions from intertidal sediments and groundwater in anthropogenically-impacted XXXX Harbor, Massachusetts.

entities_list: @entity739 :: ('MESH:D013036', 'Disease') :: ['West Falmouth']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

answer: @entity739 :: (MESH:D013036,Disease) :: ['West Falmouth']


abstract: BACKGROUND: While current theories on perception of interoceptive signals suggest impaired interoceptive processing in @entity146 such as @entity4697 or @entity308 , heart-rate (HR) interoceptive accuracy (IAc) of @entity4697 @entity1 under resting conditions is superior to that of healthy controls. Thus, in this study, we chose to assess further physiological parameters and comorbid @entity308 in order to get information on how these potentially conflicting findings are linked together. DESIGN: We used a quasi-experimental laboratory design which included multi-parametric physiological data collection of 40 @entity4697 subjects and 53 matched no- @entity4697 controls, as well as experimental induction of stress and relaxation over a time-course. METHODS: Stress reactivity, interoceptive awareness (IAw; from the Body Perception Questionnaire (BPQ)) and IAc (as correlation between self-estimation and physiological data) were major outcome variables. Self-estimation of bioparametrical change was measured via numeric rating scales. RESULT: Panic subjects had stronger HR-reaction and more accurate HR-interoception. Concurrently, though, their IAc of skin conductance level, pulse amplitude and breathing amplitude was significantly lower than that of the control group. Interestingly, comorbid @entity308 was found to be associated with increased IAw but attenuated IAc. LIMITATIONS: Demand characteristics and a categorical approach to @entity4697 confine the results. CONCLUSION: The potentially conflicting findings coalesce, as @entity4697 was associated with an increase of the ability to perceive the fear-related parameter and a simultaneous decrease of the ability to perceive other parameters. The superordinate integration of afferent signals might be impaired.

title: XXXX and their associations with stress reactivity, interoceptive awareness and interoceptive accuracy of various bioparameters.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity4697 :: ('MESH:D016584', 'Disease') :: ['panic', 'panic disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Panic and comorbid depression']


abstract: OBJECTIVE: The aim of this study was to confirm a causal relationship between removal of @entity1029 ( @entity1029 ) and lower-extremity @entity4269 after systematic lymphadenectomy in @entity1 with uterine @entity5 . METHODS: A retrospective chart review was carried out for all @entity1 with uterine corpus malignant @entity5 managed at Hokkaido Cancer Center between 1991 and 2013. All 318 @entity1 underwent @entity1029 dissection as a part of initial surgery and 217 @entity1 did not. @entity1 had undergone hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy and their medical records were reviewed. The type of lymphadenectomy gradually shifted from pelvic lymphadenectomy with @entity1029 to full lymphadenectomy without @entity1029 dissection during this period. We identified @entity1 with postoperative lower-extremity @entity4269 (POLEL). Logistic regression analysis was used to select the risk factors for POLEL. RESULTS: Of 535 @entity1 evaluated, POLEL was noted in the medical records of 126 @entity1 (23.6%), with median follow-up of 71months. The occurrence of POLEL was significantly higher in the @entity1029 -dissection group than in the @entity1029 -sparing group (34.3% vs. 7.8%, P<0.0001). Multivariate analysis confirmed that adjuvant radiation therapy [odds ratio (OR)=6.3, 95% confidence interval (CI)=2.6-14.9], resection of more than 31 lymph nodes (OR=2.0, 95% CI=1.2-3.5), and @entity1029 (OR=5.4, 95% CI=3.1-9.3) were independent risk factors for POLEL. CONCLUSIONS: Elimination of @entity1029 dissection can be helpful in reducing the incidence of POLEL.

title: Close relationship between removal of circumflex iliac nodes to distal external iliac nodes and postoperative lower-extremity XXXX in uterine corpus malignant @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1029 :: ('MESH:D017543', 'Disease') :: ['circumflex iliac nodes to the distal external iliac nodes', 'CINDEIN', 'removal of CINDEIN']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'corpus malignancies']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['lymphedema']

answer: @entity4269 :: (MESH:D008209,Disease) :: ['lymphedema']


abstract: OBJECTIVE: The aim of this study was to confirm a causal relationship between removal of @entity1029 ( @entity1029 ) and lower-extremity @entity4269 after systematic lymphadenectomy in @entity1 with uterine @entity5 . METHODS: A retrospective chart review was carried out for all @entity1 with uterine corpus malignant @entity5 managed at Hokkaido Cancer Center between 1991 and 2013. All 318 @entity1 underwent @entity1029 dissection as a part of initial surgery and 217 @entity1 did not. @entity1 had undergone hysterectomy, bilateral salpingo-oophorectomy and lymphadenectomy and their medical records were reviewed. The type of lymphadenectomy gradually shifted from pelvic lymphadenectomy with @entity1029 to full lymphadenectomy without @entity1029 dissection during this period. We identified @entity1 with postoperative lower-extremity @entity4269 (POLEL). Logistic regression analysis was used to select the risk factors for POLEL. RESULTS: Of 535 @entity1 evaluated, POLEL was noted in the medical records of 126 @entity1 (23.6%), with median follow-up of 71months. The occurrence of POLEL was significantly higher in the @entity1029 -dissection group than in the @entity1029 -sparing group (34.3% vs. 7.8%, P<0.0001). Multivariate analysis confirmed that adjuvant radiation therapy [odds ratio (OR)=6.3, 95% confidence interval (CI)=2.6-14.9], resection of more than 31 lymph nodes (OR=2.0, 95% CI=1.2-3.5), and @entity1029 (OR=5.4, 95% CI=3.1-9.3) were independent risk factors for POLEL. CONCLUSIONS: Elimination of @entity1029 dissection can be helpful in reducing the incidence of POLEL.

title: Close relationship between removal of circumflex iliac nodes to distal external iliac nodes and postoperative lower-extremity @entity4269 in uterine corpus malignant XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumors']


abstract: @entity1 with mesial @entity1315 (mTLE) frequently show @entity73 . However, the relation between mTLE and @entity73 is poorly understood. To gain more insight into @entity302 -associated alterations in cognitive performance, we studied the spatial learning of C57BL/6J @entity19 five weeks after @entity4176 -induced @entity159 ( @entity159 ). Typically, structural hippocampal rearrangements take place within five weeks after @entity159 . @entity19 were monitored by exposing them to four tasks with a focus on spatial memory and @entity148 : the circular hole board, modified hole board, novel object-placement task, and elevated plus maze. On the circular hole board, animals showed a higher preference for hippocampus-independent strategies after @entity159 . In contrast, no change in strategy was seen on the modified hole board, but animals with @entity159 were able to finish the task more often. Animals did not have an increased preference for a relocated object in the novel object-placement task but showed an increased locomotion after @entity159 . No indications for altered @entity148 were found when tested on the elevated plus maze following @entity159 . These data suggest that the circular hole board is a well-suited paradigm to detect subtle @entity159 -induced @entity131 .

title: XXXX -induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J @entity19 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['hippocampal deficits']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'cognitive deficits']

entities_list: @entity1315 :: ('MESH:D004833', 'Disease') :: ['temporal lobe epilepsy']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus', 'SE']

answer: @entity4176 :: (MESH:D007608,Chemical) :: ['Kainate']


abstract: @entity1 with mesial @entity1315 (mTLE) frequently show @entity73 . However, the relation between mTLE and @entity73 is poorly understood. To gain more insight into @entity302 -associated alterations in cognitive performance, we studied the spatial learning of C57BL/6J @entity19 five weeks after @entity4176 -induced @entity159 ( @entity159 ). Typically, structural hippocampal rearrangements take place within five weeks after @entity159 . @entity19 were monitored by exposing them to four tasks with a focus on spatial memory and @entity148 : the circular hole board, modified hole board, novel object-placement task, and elevated plus maze. On the circular hole board, animals showed a higher preference for hippocampus-independent strategies after @entity159 . In contrast, no change in strategy was seen on the modified hole board, but animals with @entity159 were able to finish the task more often. Animals did not have an increased preference for a relocated object in the novel object-placement task but showed an increased locomotion after @entity159 . No indications for altered @entity148 were found when tested on the elevated plus maze following @entity159 . These data suggest that the circular hole board is a well-suited paradigm to detect subtle @entity159 -induced @entity131 .

title: @entity4176 -induced epileptogenesis alters circular hole board learning strategy but not the performance of C57BL/6J XXXX .

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: Prefrontal cortical dysfunction is frequently reported in @entity161 and is thought to underlie negative symptoms of @entity161 . Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate neuronal activity and has been shown to improve negative symptoms in @entity1 with @entity161 , but the underlying neural mechanism is unknown. OBJECTIVE: To examine whether 3weeks of 10Hz rTMS treatment of the bilateral dorsolateral prefrontal cortex (DLPFC) would improve frontal brain activation in @entity1 with negative symptoms of @entity161 , as measured by functional magnetic resonance imaging (fMRI) during the Tower of London (ToL) task. METHODS: 24 @entity1 with the diagnosis of @entity161 with moderate to severe negative symptoms (Positive and Negative Syndrome Scale (PANSS) negative subscale>= 15) participated. @entity1 were randomized to a 3-week (15day) course of active or sham rTMS. All @entity1 performed the ToL task during fMRI scanning both pre-treatment and post-treatment. Differences in brain activation between the two groups were compared non-parametrically. RESULTS: After rTMS treatment, brain activity in the active group increased in the right DLPFC and the right medial frontal gyrus as compared to the sham group. In addition, the groups significantly differed with regard to activation change in the left posterior cingulate, with decreased activation in the active and increased activation in the sham group. CONCLUSIONS: Treatment with rTMS over the DLPFC may have the potential for increasing task-related activation in frontal areas in @entity1 with @entity161 . Effects of different rTMS parameters and fMRI tasks targeting relevant brain circuitry deserve further investigation. TRIAL REGISTRATION: Nederlands Trial Register, registration number: NTR1261.

title: Effect of rTMS on brain activation in XXXX with negative symptoms: A proof-of-principle study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: The @entity204 of a loved one is often an ordeal and a tragedy for those who witness it, as @entity204 is not merely the end of a life, but also the end of an existence, the loss of a unique individual who is special and irreplaceable. In some situations, end-of-life signs, such as agonal gasps, can be an almost unbearable "sight" because the physical manifestations are hard to watch and can lead to subjective interpretation and irrational fears. Ethical unease arises as the dying @entity1 falls prey to @entity204 throes and to the manifestations of ebbing life and the physician can only stand by and watch. From this point on, medicine can put an end to suffering by the use of @entity4094 , but in so doing life ceases at the same time. It is difficult, however, not to respond to the distress of loved ones and caregivers. The ethical problem then becomes the shift from the original ethical concern, i.e. the dying @entity1 , to the @entity1 's loved ones. Is such a @entity397 due to a difference in nature or a difference in degree, given that the dying @entity1 remains a @entity1 and not a thing as long as the body continues to lead its own life, expressed through movement and sound? Because there cannot be any simple and unequivocal answer to this question, the SRLF Ethics Commission is offering ethical reflections on end-of-life signs and symptoms in the intensive care setting, and on the use of @entity4094 in this context, with presentations on the subject by two philosophers and members of the SRLF Ethics Commission, Ms Lise Haddad and Prof Dominique Folscheid. The SRLF Ethics Commission hopes to provide food for thought for everyone on this topic, which undoubtedly calls for further contributions, the aim being not to provide ready-made solutions or policy, but rather to allow everyone to ponder this question in all conscience.

title: Ethical reflections on end-of-life signs and symptoms in the intensive care setting: a place for XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'person']

entities_list: @entity4094 :: ('MESH:D009468', 'Disease') :: ['neuromuscular blockade']

answer: @entity4094 :: (MESH:D009468,Disease) :: ['neuromuscular blockers']


abstract: BACKGROUND: A randomized trial demonstrated that a high-dose inactivated @entity683 vaccine (IIV- @entity2033 ) was 24.2% more efficacious than a standard-dose vaccine (IIV-SD) against laboratory-confirmed @entity683 in adults >= 65 years. To evaluate the consistency of IIV- @entity2033 benefits, supplemental analyses explored efficacy and immunogenicity by baseline characteristics of special interest. METHODS: Double-blind, randomized, active-controlled, multicenter trial. Adults >= 65 years were randomized 1:1 to receive IIV- @entity2033 or IIV-SD and followed for 6-8 months postvaccination for the occurrence of @entity683 . One third of @entity1 were randomly selected to provide sera for measurement of hemagglutination inhibition antibody (HAI) titers. Efficacy (IIV- @entity2033 vs. IIV-SD) against laboratory-confirmed, protocol-defined @entity683 (PD-ILI) and HAI geometric mean titer (GMT) ratios (IIV- @entity2033 /IIV-SD) were evaluated by age, and number of high-risk comorbid and frailty conditions. RESULTS: Efficacy (95% confidence intervals) of IIV- @entity2033 relative to IIV-SD against laboratory-confirmed PD-ILI was 19.7% (0.4%; 35.4%) for @entity1 65-74 years, 32.4% (8.1%; 50.6%) for those >= 75 years, 22.1% (3.9%; 37.0%) for @entity1 with >= 1 high-risk comorbidity, 23.6% (-3.2%; 43.6%) for those with >= 2 high-risk comorbidities, 27.5% (0.4%; 47.4%) for @entity1 with 1 frailty condition, 23.9% (-9.0%; 47.2%) for those with 2 frailty conditions, and 16.0% (-16.3%; 39.4%) for those with >= 3 frailty conditions. There was no evidence of vaccine efficacy heterogeneity within age, comorbidity, and frailty strata (P-values 0.351, 0.875, and 0.838, respectively). HAI GMT ratios were significantly higher among IIV- @entity2033 recipients for all strains and across all subgroups. CONCLUSIONS: Estimates of relative efficacy consistently favored IIV- @entity2033 over IIV-SD. There was no significant evidence that baseline age, comorbidity, or frailty modified the efficacy of IIV- @entity2033 relative to IIV-SD. IIV- @entity2033 significantly improved HAI responses for all strains and in all subgroups. IIV- @entity2033 is likely to provide benefits beyond IIV-SD for adults >= 65 years, irrespective of age and presence of comorbid or frailty conditions.

title: Efficacy and immunogenicity of high-dose XXXX vaccine in older adults by age, comorbidities, and frailty.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'persons']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza', 'influenza illness', 'influenza-like illness']

answer: @entity683 :: (MESH:D007251,Disease) :: ['influenza']


abstract: PURPOSE: The aim of this study is to investigate efficacy and @entity137 of 1year of @entity416 metronomic therapy preceded by standard adjuvant chemotherapy in @entity0 ( @entity0 ) @entity1 . METHODS: Between June 2010 and February 2012, 19 @entity1 with pathologically proven operable @entity0 , who had received standard adjuvant chemotherapy before were enrolled. @entity1 received 1year of oral @entity416 metronomic therapy (650mg/m(2), twice every day), after standard adjuvant chemotherapy and radiotherapy if indicated. The primary endpoints of this study were disease-free survival rates (DFS) and safety profile. Secondary end point was overall survival (OS). RESULTS: The maximal follow-up was 46.6months with a median of 30.1months   11.525 (95% CI; 28.5-33.5months). The median DFS was 41.7months   2.7 (95% CI; 36.5-46.9). No one developed locoregional recurrence. The actuarial rate of DFS was 88.8% and 82.05% at 2 and 3years, respectively. At the time of the analyses, no @entity1 had died and the median OS was not reached. Treatment-related adverse events were manageable with only 1 @entity1 (5.3%) suffering from Grade 3/4 hand-foot syndrome and another 1 @entity1 (5.3%) suffering from Grade 3 @entity294 . No Grade 3/4 hematologic @entity137 was recorded. All @entity1 received full doses of @entity416 throughout the study and dose reduction was not required in any of our @entity1 . CONCLUSION: One year of @entity416 metronomic therapy preceded by standard adjuvant chemotherapy, is active and well-tolerated in @entity0 @entity1 previously treated with standard adjuvant chemotherapy.

title: Preliminary results of @entity416 metronomic chemotherapy in operable XXXX after standard adjuvant therapy - A single-arm phase II study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['triple-negative breast cancer', 'TNBC']

entities_list: @entity416 :: ('MESH:C110904', 'Chemical') :: ['capecitabine']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

answer: @entity0 :: (MESH:D001943,Disease) :: ['triple-negative breast cancer']


abstract: PURPOSE: The aim of this study is to investigate efficacy and @entity137 of 1year of @entity416 metronomic therapy preceded by standard adjuvant chemotherapy in @entity0 ( @entity0 ) @entity1 . METHODS: Between June 2010 and February 2012, 19 @entity1 with pathologically proven operable @entity0 , who had received standard adjuvant chemotherapy before were enrolled. @entity1 received 1year of oral @entity416 metronomic therapy (650mg/m(2), twice every day), after standard adjuvant chemotherapy and radiotherapy if indicated. The primary endpoints of this study were disease-free survival rates (DFS) and safety profile. Secondary end point was overall survival (OS). RESULTS: The maximal follow-up was 46.6months with a median of 30.1months   11.525 (95% CI; 28.5-33.5months). The median DFS was 41.7months   2.7 (95% CI; 36.5-46.9). No one developed locoregional recurrence. The actuarial rate of DFS was 88.8% and 82.05% at 2 and 3years, respectively. At the time of the analyses, no @entity1 had died and the median OS was not reached. Treatment-related adverse events were manageable with only 1 @entity1 (5.3%) suffering from Grade 3/4 hand-foot syndrome and another 1 @entity1 (5.3%) suffering from Grade 3 @entity294 . No Grade 3/4 hematologic @entity137 was recorded. All @entity1 received full doses of @entity416 throughout the study and dose reduction was not required in any of our @entity1 . CONCLUSION: One year of @entity416 metronomic therapy preceded by standard adjuvant chemotherapy, is active and well-tolerated in @entity0 @entity1 previously treated with standard adjuvant chemotherapy.

title: Preliminary results of XXXX metronomic chemotherapy in operable @entity0 after standard adjuvant therapy - A single-arm phase II study.

answer: @entity416 :: (MESH:C110904,Chemical) :: ['capecitabine']


abstract: PURPOSE: Little is known about the prevalence of combined @entity148 and @entity308 (CADS) in @entity0 @entity1 . Purpose was to evaluate for differences in demographic and clinical characteristics and quality of life (QOL) prior to @entity0 surgery among @entity1 classified into one of four distinct @entity148 and/or @entity308 symptom groups. METHODS: A total of 335 @entity1 completed measures of @entity148 and @entity308 and QOL prior to and for 6 months following @entity0 surgery. Growth Mixture Modelling (GMM) was used to identify subgroups of @entity1 with distinct trajectories of @entity148 and @entity308 . These results were used to create four distinct @entity148 and/or @entity308 symptom groups. Differences in demographic, clinical, and symptom characteristics, among these groups were evaluated using analyses of variance and Chi square analyses. RESULTS: A total of 44.5% of @entity1 were categorized with CADS. @entity1 with CADS were younger, non-white, had lower performance status, received neoadjuvant or adjuvant chemotherapy, had greater difficulty dealing with their disease and treatment, and reported less support from others to meet their needs. These @entity1 had lower physical, psychological, social well-being, and total QOL scores. Higher levels of @entity148 with or without @entity308 were associated with increased fears of recurrence, hopelessness, uncertainty, loss of control, and a decrease in life satisfaction. CONCLUSIONS: Findings suggest that CADS occurs in a high percentage of @entity1 following @entity0 surgery and results in a poorer QOL. Assessments of @entity148 and @entity308 are warranted prior to surgery for @entity0 .

title: Co-occurrence of XXXX and @entity308 following @entity0 surgery and its impact on quality of life.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms', 'subsyndromal depressive symptoms', 'depressive']

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: PURPOSE: Little is known about the prevalence of combined @entity148 and @entity308 (CADS) in @entity0 @entity1 . Purpose was to evaluate for differences in demographic and clinical characteristics and quality of life (QOL) prior to @entity0 surgery among @entity1 classified into one of four distinct @entity148 and/or @entity308 symptom groups. METHODS: A total of 335 @entity1 completed measures of @entity148 and @entity308 and QOL prior to and for 6 months following @entity0 surgery. Growth Mixture Modelling (GMM) was used to identify subgroups of @entity1 with distinct trajectories of @entity148 and @entity308 . These results were used to create four distinct @entity148 and/or @entity308 symptom groups. Differences in demographic, clinical, and symptom characteristics, among these groups were evaluated using analyses of variance and Chi square analyses. RESULTS: A total of 44.5% of @entity1 were categorized with CADS. @entity1 with CADS were younger, non-white, had lower performance status, received neoadjuvant or adjuvant chemotherapy, had greater difficulty dealing with their disease and treatment, and reported less support from others to meet their needs. These @entity1 had lower physical, psychological, social well-being, and total QOL scores. Higher levels of @entity148 with or without @entity308 were associated with increased fears of recurrence, hopelessness, uncertainty, loss of control, and a decrease in life satisfaction. CONCLUSIONS: Findings suggest that CADS occurs in a high percentage of @entity1 following @entity0 surgery and results in a poorer QOL. Assessments of @entity148 and @entity308 are warranted prior to surgery for @entity0 .

title: Co-occurrence of @entity148 and XXXX following @entity0 surgery and its impact on quality of life.

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']


abstract: PURPOSE: Little is known about the prevalence of combined @entity148 and @entity308 (CADS) in @entity0 @entity1 . Purpose was to evaluate for differences in demographic and clinical characteristics and quality of life (QOL) prior to @entity0 surgery among @entity1 classified into one of four distinct @entity148 and/or @entity308 symptom groups. METHODS: A total of 335 @entity1 completed measures of @entity148 and @entity308 and QOL prior to and for 6 months following @entity0 surgery. Growth Mixture Modelling (GMM) was used to identify subgroups of @entity1 with distinct trajectories of @entity148 and @entity308 . These results were used to create four distinct @entity148 and/or @entity308 symptom groups. Differences in demographic, clinical, and symptom characteristics, among these groups were evaluated using analyses of variance and Chi square analyses. RESULTS: A total of 44.5% of @entity1 were categorized with CADS. @entity1 with CADS were younger, non-white, had lower performance status, received neoadjuvant or adjuvant chemotherapy, had greater difficulty dealing with their disease and treatment, and reported less support from others to meet their needs. These @entity1 had lower physical, psychological, social well-being, and total QOL scores. Higher levels of @entity148 with or without @entity308 were associated with increased fears of recurrence, hopelessness, uncertainty, loss of control, and a decrease in life satisfaction. CONCLUSIONS: Findings suggest that CADS occurs in a high percentage of @entity1 following @entity0 surgery and results in a poorer QOL. Assessments of @entity148 and @entity308 are warranted prior to surgery for @entity0 .

title: Co-occurrence of @entity148 and @entity308 following XXXX surgery and its impact on quality of life.

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: The functional coupling of transplanted cells with host myocardial cells is a significant challenge in mesenchymal stem cell (MSC) cardiomyoplasty being related to cell survival and therapeutic outcomes. Priming of MSCs with growth factors has been reported to improve their therapeutic efficacy through gap junction-mediated mechanisms. However, the expression pattern of @entity495 ( @entity495 ) in growth factor-stimulated MSC was not previously addressed. In this study we investigated how the pre-treatment with growth factors modulates MSC ability to integrate into the host tissue after transplantation, with particular focus on the expression of @entity495 and its cellular distribution. Our results showed that stimulation of MSCs with @entity442 , @entity540 , but not TGFb, increased the level of @entity495 at both mRNA and protein levels. @entity442 stimulation resulted in a shift of the fibroblast morphology into an epithelial morphology in several well-defined areas of stimulated cells. Confocal microscopy examination revealed that the increase of @entity495 was restricted to the epithelial-like cells and did not occur in other cells. In variance, @entity540 induced a rod-shape morphology of every single cell, which achieved an extremely low cell index. @entity540 stimulation also induced a time-dependent increase in @entity495 , with a regular distribution pattern in all cells. Dye transfer assay coupled with confocal microscopy and flow cytometry analysis demonstrated functional in vitro cell coupling between @entity540 -stimulated MSCs as well as between @entity540 -stimulated cells and H9c2 cardiomyoblasts, a scenery that mimick MSC transplantation into the myocardium. We conclude that the stimulation of MSCs with @entity540 prior to transplantation may facilitate their access among the myocardial cells and increase the functional coupling between transplanted and host cells.

title: Pre-stimulation with XXXX increases in vitro functional coupling of mesenchymal stem cells with cardiac cells.

answer: @entity540 :: (2247,Gene) :: ['FGF-2']


abstract: A retrospective study of @entity957 (SCC) @entity1 attending a department of oral and maxillofacial surgery was performed for the period 2000-2010. The clinical information of 100 cases treated during this period was acquired and analyzed. @entity1 survival was calculated using the Kaplan-Meier method. For these 100 cases, the total metastatic rate was 34.0% and occult metastatic rate was 27.5%. Positive lymph nodes were mostly detected at levels I-III. There was no significant difference in metastatic rate between the primary sites of maxillary gingiva and hard palate. @entity5 involving the gingival-buccal sulcus presented a significantly higher risk of @entity3 . Advanced stage (T3/4) was significantly correlated with a higher @entity3 rate. The pathological grade also showed a significant relationship with @entity3 . Twenty-four @entity1 presented regional recurrence. Elective neck dissection could significantly reduce the recurrence rate. The overall 3-year and 5-year survival rates were 66.3% and 56.7%, respectively. Both the T and the N stages had a significant impact on survival rates. Selective neck dissection from level I to III is recommended for T3/4 stage cN0 @entity1 , especially those with gingival-buccal sulcus involvement.

title: Cervical @entity3 of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['maxillary squamous cell carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumours']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity957 :: (MESH:D002294,Disease) :: ['maxillary squamous cell carcinoma']