abstract: BACKGROUND: The majority of @entity1 with @entity43 (EOC) relapse after initially responding to @entity902 -based chemotherapy, and develop resistance. The genomic features involved in drug resistance are unknown. To unravel some of these features, we investigated the mutational profile of genes involved in pathways related to drug sensitivity in a cohort of matched @entity5 obtained at first surgery (Ft-S) and second surgery (Sd-S). @entity1 AND METHODS: Matched biopsies (33) taken at Ft-S and Sd-S were selected from the 'Pandora' @entity5 tissue collection. DNA libraries for 65 genes were generated using the TruSeq Custom Amplicon kit and sequenced on MiSeq (Illumina). Data were analyzed using a high-performance cluster computing platform (Cloud4CARE project) and independently validated. RESULTS: A total of 2270 somatic mutations were identified (89.85% base substitutions 8.19% indels, and 1.92% unknown). Homologous recombination (HR) genes and @entity876 were mutated in the majority of Ft-S, while ATM, ATR, @entity14583 and @entity5255 were mutated in the entire dataset. Only 2% of mutations were conserved between matched Ft-S and Sd-S. Mutations detected at second surgery clustered @entity1 in two groups characterized by different mutational profiles in genes associated with HR, @entity10412 , miRNA biogenesis and signal transduction. CONCLUSIONS: There was a low level of concordance between Ft-S and Sd-S in terms of mutations in genes involved in key processes of @entity5 growth and drug resistance. This result suggests the importance of future longitudinal analyses to improve the clinical management of relapsed EOC.

title: Profiling @entity5 gene mutations in XXXX biopsies by targeted next-generation sequencing: a retrospective study.

answer: @entity43 :: (MESH:D010051,Disease) :: ['longitudinal epithelial ovarian cancer']


abstract: UNASSIGNED: MicroRNAs play critical roles in regulating @entity5 occurrence and drug @entity43 . This study aimed to investigate the key members of MicroRNAs (miRNAs) involved in modulating @entity5 initiation and drug resistance in primary @entity43 cells. An in vitro assay based on @entity5 clonal formation was established to evaluate tumorigenicity and @entity900 sensitivity. By performing real-time polymerase chain reaction, we examined the expression of nine microRNAs associated with the pathology of @entity43 in primary @entity43 cells, which were surgically resected from 46 @entity1 with distinct sensitivity to @entity902 -based chemotherapy. MiR-9, @entity3373 , and @entity27165 were expressed significantly higher in drug-sensitive @entity1 (n   =   26) than in drug-resistant ones (n   =   20), while higher @entity17309 expression was found in resistant @entity1 (p   <   0.05). In addition, @entity5 cells from drug sensitive @entity1 were more tumorigenic than those of drug resistance (p   =   0.0013). @entity900 treatment led to a sharp decrease of clonal formation of drug-sensitive cells but showed slight effects on drug resistant cells. Specific anti-miRs were then employed to downregulate the expression of microRNAs in primary @entity5 cells. Inhibition of miR-9 resulted in decreased clonal formation and sensitivity to @entity900 , while the knockdown of other three microRNAs did not show any influence in tumorigenesis and drug sensitivity. In conclusion, this study showed that in primary @entity43 cells, high expression of miR-9 was associated with enhanced tumorigenesis and increased sensitivity of the @entity5 cells to @entity900 treatment.

title: MicroRNA-9 promotes tumorigenesis and mediates sensitivity to XXXX in primary @entity43 cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancers', 'sensitivity in ovarian cancers', 'ovarian tumor', 'ovarian cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']


abstract: UNASSIGNED: MicroRNAs play critical roles in regulating @entity5 occurrence and drug @entity43 . This study aimed to investigate the key members of MicroRNAs (miRNAs) involved in modulating @entity5 initiation and drug resistance in primary @entity43 cells. An in vitro assay based on @entity5 clonal formation was established to evaluate tumorigenicity and @entity900 sensitivity. By performing real-time polymerase chain reaction, we examined the expression of nine microRNAs associated with the pathology of @entity43 in primary @entity43 cells, which were surgically resected from 46 @entity1 with distinct sensitivity to @entity902 -based chemotherapy. MiR-9, @entity3373 , and @entity27165 were expressed significantly higher in drug-sensitive @entity1 (n   =   26) than in drug-resistant ones (n   =   20), while higher @entity17309 expression was found in resistant @entity1 (p   <   0.05). In addition, @entity5 cells from drug sensitive @entity1 were more tumorigenic than those of drug resistance (p   =   0.0013). @entity900 treatment led to a sharp decrease of clonal formation of drug-sensitive cells but showed slight effects on drug resistant cells. Specific anti-miRs were then employed to downregulate the expression of microRNAs in primary @entity5 cells. Inhibition of miR-9 resulted in decreased clonal formation and sensitivity to @entity900 , while the knockdown of other three microRNAs did not show any influence in tumorigenesis and drug sensitivity. In conclusion, this study showed that in primary @entity43 cells, high expression of miR-9 was associated with enhanced tumorigenesis and increased sensitivity of the @entity5 cells to @entity900 treatment.

title: MicroRNA-9 promotes tumorigenesis and mediates sensitivity to @entity900 in primary XXXX cells.

answer: @entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian cancer']


abstract: UNASSIGNED: Sequence variation in a region of the virulence array protein gene (vapA; A-layer) was assessed in 333 ('typical' and 'atypical') isolates of the fish pathogenic bacterium @entity6464 . Resulting similarity dendrograms revealed extensive heterogeneity, with nearly all isolates belonging to either of 14 distinct clusters or A-layer types. All acknowledged A.  salmonicida subspecies (except ssp. pectinolytica, from which no vapA sequence could be obtained) were clearly separated, and notably, all isolates phenotypically identified as ssp. salmonicida formed a distinct and exclusive @entity1129 . Additionally, an array of un-subspeciated @entity6475 formed several equally prominent clusters, demonstrating that the concept of typical/atypical A.  salmonicida is inappropriate for describing the high degree of diversity evidently occurring outside ssp. salmonicida. Most representatives assessed in this study were clinical isolates of spatiotemporally diverse origins, and were derived from a variety of hosts. We observed that from several fish species or families, isolates predominantly belonged to certain A-layer types, possibly indicating a need for host-/ @entity1129 -specific A.  salmonicida vaccines. All in all, A-layer typing shows promise as an inexpensive and rapid means of unambiguously distinguishing clinically relevant A.  salmonicida subspecies, as well as presently un-subspeciated @entity6475 .

title: vapA (A-layer) typing differentiates XXXX and identifies a number of previously undescribed subtypes.

entities_list: @entity6475 :: ('MESH:D013180', 'Disease') :: ['atypical strains']

entities_list: @entity6464 :: ('645', 'Species') :: ['Aeromonas salmonicida']

entities_list: @entity1129 :: ('MESH:D001260', 'Disease') :: ['A-layer type']

answer: @entity6464 :: (645,Species) :: ['Aeromonas salmonicida subspecies']


abstract: UNASSIGNED: Obstructive sleep @entity386 is prevalent and adversely affects @entity65 . However, little is known of the acute effects of an obstructive @entity386 on cardiovascular physiology. We hypothesized that pre-existing functional @entity339 ( @entity339 ) would worsen during performance of a Mueller maneuver (MM) used to simulate an obstructive @entity386 ; 15 subjects with an ejection fraction  <=35% and pre-existing functional @entity339 were studied with Doppler echocardiography. The radius of the proximal flow convergence was used as a measure of mitral regurgitant flow. Measurements were made at baseline, during the MM, and post-MM. Areas of all 4 chambers were also measured at these time points, both in systole and diastole. Mean flow convergence radius for the group decreased significantly during the transition from the late-MM to post-MM (0.65  >  0.57  mm, p  = 0.001), implying increased @entity339 during the MM. In addition, in 3 subjects, duration of @entity339 increased during the MM. @entity4032 ( @entity4032 ) areas, both systolic and diastolic, increased during the maneuver, whereas @entity4032 fractional area change decreased, indicating reduced @entity4032 emptying. Left ventricular emptying decreased early in the maneuver, probably because of the increased afterload burden, and then recovered. In conclusion, high negative intrathoracic pressure produces changes that, repeated hundreds of times per night in @entity1 with @entity27 , have the potential to worsen @entity712 and predispose affected subjects to @entity955 .

title: Effects of the Mueller Maneuver on Functional Mitral Regurgitation and Implications for Obstructive Sleep XXXX .

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['MR', 'mitral regurgitation']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity4032 :: ('MESH:D059446', 'Disease') :: ['Right atrial', 'RA']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular health']

answer: @entity386 :: (MESH:D001049,Disease) :: ['Apnea']


abstract: PURPOSE: To describe the clinical presentation, management and outcome of @entity1781 ( @entity1781 ) @entity1 in order to find markers for this diagnosis among @entity2743 ( @entity2743 ) @entity1 . METHODS: We conducted a retrospective review of the medical records of 15 @entity1 presenting with clinical and radiologic evidence of @entity1781 , from a series of 131 @entity1 with @entity2743 , treated at our health care center between the years 1999 and 2008. The worse eye of each of the 15 @entity1781 @entity1 was determined according to visual acuity and @entity227 , and was paired with an eye of a matched @entity1 from the @entity2743 group. Paired comparisons were performed in order to appreciate the differences in the rates of various signs and symptoms between both groups. RESULTS: A total of 15 @entity1 (11%), mean age 55 years (range 37-76 years) were diagnosed with @entity1781 , (53%) of them were smokers. The most common manifestations among @entity1781 @entity1 were @entity5768 (78%), @entity227 (76%) and restriction of abduction (73%). In a paired comparison between the worse eye of @entity1781 @entity1 and their counterparts in the @entity2743 group, statistically significant differences were noted in the rate of @entity5768 (p = 0.02), extent of @entity227 (p = 0.001), @entity227 (p = 0.02) and abduction limitation (p = 0.02). A trend with no statistical significance was demonstrated for the difference in adduction limitation (p = 0.06). CONCLUSIONS: The clinical presentation and management of @entity1781 @entity1 is described in a cohort of 15 @entity1 . As @entity227 and restriction of abduction were the most common signs with the diagnosis of @entity1781 , we recommend follow-up to include routine @entity227 in @entity2743 @entity1 . Treatment with intravenous @entity288 and decompressive surgery was shown to be effective in our cohort.

title: [Clinical characteristics of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field mean deviation', 'visual field damage', 'visual field screening', 'visual field defects']

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ['GO', "Graves' orbitopathy", 'Graves orbitopathy']

entities_list: @entity5768 :: ('MESH:D005094', 'Disease') :: ['proptosis']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['DON', 'optic neuropathy', 'dysthyroid optic neuropathy']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity1781 :: (MESH:D009901,Disease) :: ['dysthyroid optic neuropathy']


abstract: UNASSIGNED: Horticulture makes intensive use of soil and extensive use of @entity691 (PE) sheeting and pesticides, producing an environment where the dynamics between soil and plastics can affect pesticide fate. We have determined that the presence of plastic residues in the horticultural soil of small production units equals 10% of the soil area, being meso and macro-sections the predominant fragment sizes. All soil samples were taken from different plots located in Cuartel V, Moreno district, in the suburbs of Buenos Aires city, Argentina. Laboratory experiments were conducted to see the relations among pesticide, soil and PE film. Endosulfan recovery from LDPE films (25 m and 100 m) was studied, observing evidence that indicated migration to the inside of the plastic matrix. To further analyze the dynamics of pesticide migration to soil and atmosphere, experiments using @entity10687 , @entity22429 and @entity14459 were performed in soil-plastic-atmosphere microenvironments, showing that up to 24h significant amounts of pesticides moved away from the PE film. To determine whether PE residues could act as potential pesticide collector in soil, column elution experiments were done using @entity10687 , @entity22429 and @entity14459 . Results showed an important pesticide accumulation in the mulch film (584 g-2284 g pesticide/g plastic) compared to soil (13 g-32 g pesticide/g soil). Finally, chemical and photochemical degradation of @entity316 adsorbed in PE film was studied, finding a protective effect on hydrolysis but no protective effect on photodegradation. We believe that a deeper understanding of the dynamics among soil, plastic and pesticides in horticultural productive systems may contribute to alert for the implications of PE use for plastic sheeting.

title: XXXX film incorporation into the horticultural soil of small periurban production units in Argentina.

entities_list: @entity691 :: ('MESH:D020959', 'Chemical') :: ['polyethylene']

entities_list: @entity22429 :: ('MESH:C035988', 'Chemical') :: ['procymidone']

entities_list: @entity14459 :: ('MESH:D014274', 'Chemical') :: ['trifluralin']

entities_list: @entity316 :: ('MESH:C017180', 'Chemical') :: ['deltamethrin']

entities_list: @entity10687 :: ('MESH:D004390', 'Chemical') :: ['chlorpyrifos']

answer: @entity691 :: (MESH:D020959,Chemical) :: ['Polyethylene']


abstract: BACKGROUND: Appalachia has high @entity14 ( @entity14 ) incidence and mortality, at least in part due to screening disparities. This paper examines patterns and determinants of metastatic @entity14 care. METHODS: @entity14 @entity1 diagnosed in 2006-2008 from 4 @entity5 registries (Kentucky, Ohio, @entity4933 ) were linked to Medicare claims (2005-2009.) The final sample after exclusions included 855 stage IV and 590 stages I-III @entity1 with metachronous or synchronous metastases. We estimate bivariate and multivariate analyses for several surgical and chemotherapeutic strategies of care using clinical, sociodemographic, and contextual determinants. RESULTS: Among 1,445 @entity14 @entity1 , 84% had @entity5 resection and 44% received chemotherapy. Of the chemotherapy @entity1 , 44% received newer systemic agents for at least 75% of the cycles. One year survivors with liver or lung metastases were more likely to have their @entity5 resected immediately (86.1% vs 69.5% for liver, and 78.2% vs 64.9% for lung) and have their metastases resected/ablated (15.7% vs 2.6% for liver and 15.0% vs 0.5% for lung). @entity1 with stages I-III primary @entity5 (versus IV) were much more likely to be resected, but they were less likely to receive chemotherapy. @entity1 with comorbidities ( @entity712 , @entity303 , or @entity1576 ) had lower odds of chemotherapy. Smaller hospital size and surgical volume had higher odds of immediate versus delayed surgery. The newer chemotherapeutic agents were more common with higher surgical volume. CONCLUSIONS: Metastatic @entity14 has clinical, sociodemographic, and service provider determinants.

title: Patterns of Care for Metastatic XXXX in Appalachia, and the Clinical, Sociodemographic, and Service Provider Determinants.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4933 :: ('MESH:C537835', 'Disease') :: ['Pennsylvania, and North Carolina']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'primary tumor', 'tumors']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: Sexual reproduction allows @entity1417 ( @entity1417 ) to proliferate, leading to rapid divergence between populations and species. A significant outcome of divergence in the TE landscape is evident in @entity8625 , a strong form of genomic incompatibility that can arise when (TE) family abundance differs between two parents. When @entity1417 inherited from the father are absent in the mother's genome, @entity1417 can become activated in the progeny, causing germline @entity16 . Studies in @entity238 indicate that @entity16490 can occur when @entity1417 inherited paternally are not matched with a pool of corresponding TE silencing PIWI-interacting RNAs (piRNAs) provisioned by the female germline. Using the @entity18308 syndrome of hybrid @entity16490 as a model, we characterize the effects that divergence in TE profile between parents has on offspring. Overall, we show that divergence in the TE landscape is associated with persisting differences in germline TE expression when comparing genetically identical females of reciprocal crosses and these differences are transmitted to the next generation. Moreover, chronic and persisting TE expression coincides with increased levels of genic piRNAs associated with reduced gene expression. Combined with these effects, we further demonstrate that gene expression is idiosyncratically influenced by differences in the genic piRNA profile of the parents that arise though polymorphic TE insertions. Overall, these results support a model in which early germline events in @entity16490 establish a chronic, stable state of both TE and gene expression in the germline that is maintained through adulthood and transmitted to the next generation. This work demonstrates that divergence in the TE profile is associated with diverse piRNA-mediated transgenerational effects on gene expression within populations.

title: piRNAs Are Associated with Diverse Transgenerational Effects on Gene and Transposon Expression in a Hybrid Dysgenic Syndrome of XXXX .

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['damage and sterility']

entities_list: @entity1417 :: ('MESH:C565217', 'Disease') :: ['transposable elements', 'TEs']

entities_list: @entity16490 :: ('MESH:D050033', 'Disease') :: ['dysgenesis']

entities_list: @entity8625 :: ('MESH:D015456', 'Disease') :: ['hybrid dysgenic syndromes']

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

answer: @entity18308 :: (7244,Species) :: ['D. virilis']


abstract: OBJECTIVE: To evaluate the efficacy and safety of Chinese herbal medicine combined with systemic chemotherapy and/or regional arterial perfusion for @entity788 with liver metastases (PCLM). METHODS: We retrospectively selected 292 @entity1 with PCLM who were treated by Chinese herbal medicine combined with systemic chemotherapy and/or regional arterial perfusion at Tianjin Medical University Cancer Hospital from January 2001 to December 2010. All @entity1 were assigned to the Western medicine treatment group (157 cases) and the integrative medicine treatment group (135 cases). @entity1 in the Western medicine treatment group were treated with @entity136 ( @entity14113 )-based chemotherapy, and partial of them received regional arterial perfusion. Those in the integrative medicine treatment group additionally took Chinese herbs of clearing heat and eliminating mass for at least 4 weeks. The @entity1349 ( @entity1349 ) , adverse reactions and the incidence of complications were observed. RESULTS: There was no statistical significance in general data between the two groups (P > 0.05). There was statistical difference in @entity1349 between the two groups (4.8 months vs 5.5 months, P < 0.05). No @entity204 occurred during chemotherapy or regional arterial perfusion. All toxic or adverse reactions were tolerable. CONCLUSION: Chinese herbal medicine combined with systemic chemotherapy and/or regional arterial perfusion was effective and safe, and it could be optimally selected as palliative therapy for PCLM.

title: [A Retrospective Study of Chinese Herbal Medicine Combined with Systemic Chemotherapy and/or Regional Arterial Perfusion for XXXX with Liver Metastases].

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['median survival time', 'MST']

answer: @entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']


abstract: UNASSIGNED: The simultaneous determination of two @entity2961 pesticides ( @entity17284 and @entity9454 ) and of the degradation product of @entity17284 ( @entity20780 ) in iceberg lettuce was achieved by means of PARAFAC decomposition and excitation-emission fluorescence matrices. A standard addition method for a calibration based on four-way data was applied using different dilutions of the extract from iceberg lettuce as a fourth way that provided the enough variation of the matrix to carry out the four-way analysis. A high fluorescent overlapping existed between the three analytes and the fluorophores of the matrix. The identification of two fluorescent matrix constituents through the four-way model enabled to know the matrix contribution in each dilution of the extract. This contribution was subtracted from the previous signals and a subsequent three-way analysis was carried out with the tensors corresponding to each dilution. The PARAFAC decomposition of these resulting tensors showed a CORCONDIA index equal to 99%. For the identification of the analytes, the correlation between the PARAFAC spectral loadings and the reference spectra has been used. The trueness of the method, in the concentration range studied, was guaranteed because there was neither constant nor proportional bias according to the appropriate hypothesis tests. The best recovery percentages were obtained with the data from the most diluted extract, being the results: 127.6% for @entity17284 , 125.55% for @entity9454 and 87.6% for @entity20780 . When the solvent calibration was performed, the decision limit (CCa) and the capability of detection (CCb) values, in x0=0, were 2.21 and 4.38 gL(-1) for @entity17284 , 4.87 and 9.64 gL(-1) for @entity9454 ; and 3.22 and 6.38 gL(-1) for @entity20780 , respectively, for probabilities of false positive and false negative fixed at 0.05. However, these values were 5.30 and 10.49 gL(-1) for @entity17284 , 18.05 and 35.73 gL(-1) for @entity9454 ; and 1.92 and 3.79 gL(-1) for @entity20780 , respectively, when the matrix-matched calibration using the most diluted extract was carried out in the recovery study.

title: Standard addition method based on four-way PARAFAC decomposition to solve the matrix interferences in the determination of XXXX pesticides in lettuce using excitation-emission fluorescence data.

entities_list: @entity9454 :: ('MESH:C006698', 'Chemical') :: ['carbendazim']

entities_list: @entity2961 :: ('CHEBI:28616', 'Chemical') :: ['carbamate']

answer: @entity2961 :: (CHEBI:28616,Chemical) :: ['carbamate']


abstract: In order to test the feasibility of cementum annulations to estimate age in @entity1 , @entity2246 variability in cementum ring counts were evaluated in a sample of 42 mandibular @entity235 and first @entity2651 . Additionally, two sectioning techniques were evaluated. Demineralized thin sections (7 micron) stained with @entity1710 are the preferred technique since their age related variance is greater than 75% for all tooth types examined. In contrast, less than 50% of the total variance was accounted for among individuals when mineralized sections (80 micron) stained with @entity622 red were used. Intertooth variability in ring counts of demineralized sections was large between @entity235 and @entity2651 (43%). Premolars provide counts with lower interobserver error and are the preferred tooth. In an expanded sample (N = 51) of demineralized @entity2651 , intraobserver and interobserver error accounted for 2% and 5% of the total variance, respectively. Evaluation of several experimental designs showed that increasing the number of slides per tooth has the greatest effect on reducing variance followed by increasing the number of observers. Increasing the number of observations has little effect. Cementum ring counts are measurable to a highly repeatable extent and provide a level of repeatability greater than that reported for the pubic symphysis and auricular surface aging techniques.

title: Cementum annulation and age determination in XXXX . I. Tooth variability and observer error.

entities_list: @entity2651 :: ('MESH:D000848', 'Disease') :: ['premolars', 'premolar pairs']

entities_list: @entity235 :: ('9615', 'Species') :: ['canine', 'canines']

entities_list: @entity622 :: ('MESH:C010078', 'Chemical') :: ['alizarin']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity2246 :: ('MESH:D008661', 'Disease') :: ['observer error and tooth']

answer: @entity1 :: (9606,Species) :: ['Homo sapiens']


abstract: PURPOSE: To evaluate corneal power distribution using the ray tracing method (corneal power) in eyes undergoing small incision lenticule extraction (SMILE) surgery and compare the functional optical zone with two lenticular sizes. METHODS: This retrospective study evaluated 128 @entity1 who underwent SMILE for the correction of @entity1714 and @entity940 with a lenticular diameter of 6.5 mm (the 6.5-mm group) and 6.2 mm (the 6.2-mm group). The data include refraction, correction, and corneal power obtained via a Scheimpflug camera from the pupil center to 8 mm. The surgically induced changes in corneal power (  corneal power) were compared to correction and   refraction. The functional optical zone was defined as the largest ring diameter when the difference between the ring power and the pupil center power was 1.50 diopters or less. The functional optical zone was compared between two lenticular diameter groups. RESULTS: Corneal power distribution was measured by the ray tracing method. In the 6.5-mm group (n=100),   corneal power at 5 mm showed the smallest difference from   refraction and   corneal power at 0 mm exhibited the smallest difference from correction. In the 6.2-mm group (n=28),   corneal power at 2 mm displayed the lowest dissimilarity from   refraction and   corneal power at 4 mm demonstrated the lowest dissimilarity from correction. There was no significant difference between the mean postoperative functional optical zones in either group when their spherical equivalents were matched. CONCLUSIONS: Total corneal refactive power can be used in the evaluation of surgically induced changes following SMILE. A lenticular diameter of 6.2 mm should be recommended for @entity1 with @entity1714 because there is no functional difference in the optical zone.

title: Corneal Power Distribution and Functional Optical Zone Following Small Incision Lenticule Extraction for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity940 :: ('MESH:D001251', 'Disease') :: ['astigmatism']

entities_list: @entity1714 :: ('MESH:D009216', 'Disease') :: ['myopia', 'high myopia']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['Myopia']


abstract: PURPOSE: To analyze the refractive outcomes and satisfaction of presbyopic hyperopes treated with central presbyopicLASIK (presbyLASIK) with induced micro-monovision. METHODS: This retrospective study included 74 eyes of 37 @entity1 treated with central presbyLASIK with micro-monovision using the Technolas 217P excimer laser (Technolas Perfect Vision GmbH, Munich, Germany) between June 2011 and March 2014. Study parameters included uncorrected distance visual acuity (UDVA) and uncorrected near visual acuity (UNVA), aberrometry, the central steep zone, and @entity1 satisfaction. RESULTS: Median age was 54.3  4 years (range: 46 to 63 years). Mean postoperative spherical equivalent refraction was 0.00  0.58 diopters (D) for dominant eyes and -0.51  0.54 D for non-dominant eyes. Mean binocular UDVA was 0.01  0.10 logMAR (Snellen 20/20) at 6 months and -0.01  0.05 logMAR ( @entity7743 year postoperatively. Mean binocular UNVA was 0.18  0.14 logMAR (Parinaud 2) (Jaeger 1) at 6 months and 0.18  0.12 logMAR (Parinaud 2) (Jaeger 1) at 1 year postoperatively. At 6 months, 79.31% of @entity1 achieved 20/25 and could read Parinaud 2 (Jaeger 1) binocularly. At 1 year, 84.21% of @entity1 achieved 20/25 and could read Parinaud 2 (Jaeger 1) binocularly. The mean central steep zone was 2.35  1.00 D. There were significantly more negative spherical aberration and vertical @entity772 in the central 5 mm postoperatively (P<.05). The re-treatment rate was 6.75%. Eighty-three percent of these @entity1 did not need any glasses for distance and near vision. CONCLUSIONS: This procedure may improve functional near, intermediate, and distance vision in presbyopic @entity1 with low and moderate @entity3467 .

title: Central PresbyLASIK for XXXX and Presbyopia Using Micro-monovision With the Technolas 217P Platform and SUPRACOR Algorithm.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3467 :: ('MESH:D006956', 'Disease') :: ['hyperopia']

answer: @entity3467 :: (MESH:D006956,Disease) :: ['Hyperopia']


abstract: PURPOSE: To evaluate the long-term refractive and visual stability and the risks related to the implantation of Implantable Collamer Lens (ICL; STAAR Surgical, Monrovia, CA) phakic intraocular lens (PIOL) for @entity1714 . METHODS: This retrospective, consecutive, cumulative clinical study was performed in a group of 144 eyes implanted with ICL PIOL for @entity1714 . Only the cases with clinical data available 12 years after the implantation were included in the series. Corrected distance visual acuity (CDVA), uncorrected distance visual acuity, spherical equivalent, refractive @entity940 , endothelial cell density, ICL vaulting, and @entity260 were analyzed. RESULTS: Mean spherical equivalent refraction was -16.90  4.26 diopters (D) preoperatively and -1.77  1.93 D 12 years postoperatively. Mean CDVA at the first and last visit were 0.31  0.19 logMAR and 0.22  0.22 logMAR, respectively (Mann-Whitney U test, P<.001). Twelve years postoperatively, 8.9% of eyes had lost more than two lines of CDVA. The incidence of clinically relevant @entity231 (13.88%) was significantly linked to the use of the V3 model ICL (chi-square test, P=.007). During the follow-up period, a significant reduction in PIOL vaulting was observed (Kruskal-Wallis test, P<.05), and the mean endothelial cell density decreased by 19.75%. CONCLUSIONS: The ICL PIOL provided good refractive outcomes and stability in the long term. The incidence of @entity231 is low when the latest models of this PIOL are used.

title: Implantable Collamer Lens for XXXX : Assessment 12 Years After Implantation.

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataracts']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['Myopia']


abstract: The purpose of this study was to clarify how changes in acid-base balance influence the rate of @entity1133 synthesis in vivo. Since ureagenesis was increased by an @entity3104 infusion into @entity35 , regulation seemed to be a function of the blood @entity3104 concentration. The rate of @entity1133 synthesis was constant at a fixed rate of @entity3104 infusion and independent of the conjugate base infused, @entity2865 or @entity3157 . The steady-state blood @entity3104 concentration was higher in the @entity35 that developed @entity520 . Thus it appeared that regulation was not directly mediated by this @entity3104 concentration per se. The rate of @entity1133 synthesis was also independent of the blood pH. Accordingly, the rate of @entity1133 synthesis was examined as a function of the plasma @entity3655 concentration. The rate of ureagenesis was found to be directly proportional to the plasma @entity3655 concentration. Assuming that plasma @entity3655 levels reflect those in mitochondria, the @entity3655 concentration yielding half-maximal rates of @entity1133 synthesis (close to 2 microM) was in the same range as Km for the rate-limiting step in ureagenesis, @entity12116 synthetase (EC 6.3.4.16). These results suggest that, at a constant @entity3104 concentration, the decreased rate of ureagenesis caused by a pH fall in vitro could reflect an @entity520 -induced decline in the concentration of true substrate ( @entity3655 ) for this pathway.

title: Regulation of @entity1133 synthesis by acid-base balance in vivo: role of XXXX concentration.

entities_list: @entity12116 :: ('MESH:D002221', 'Chemical') :: ['carbamoyl phosphate']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis', 'metabolic acidosis']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

entities_list: @entity3104 :: ('MESH:D000644', 'Chemical') :: ['ammonium']

answer: @entity3655 :: (CHEBI:16134,Chemical) :: ['NH3']


abstract: The purpose of this study was to clarify how changes in acid-base balance influence the rate of @entity1133 synthesis in vivo. Since ureagenesis was increased by an @entity3104 infusion into @entity35 , regulation seemed to be a function of the blood @entity3104 concentration. The rate of @entity1133 synthesis was constant at a fixed rate of @entity3104 infusion and independent of the conjugate base infused, @entity2865 or @entity3157 . The steady-state blood @entity3104 concentration was higher in the @entity35 that developed @entity520 . Thus it appeared that regulation was not directly mediated by this @entity3104 concentration per se. The rate of @entity1133 synthesis was also independent of the blood pH. Accordingly, the rate of @entity1133 synthesis was examined as a function of the plasma @entity3655 concentration. The rate of ureagenesis was found to be directly proportional to the plasma @entity3655 concentration. Assuming that plasma @entity3655 levels reflect those in mitochondria, the @entity3655 concentration yielding half-maximal rates of @entity1133 synthesis (close to 2 microM) was in the same range as Km for the rate-limiting step in ureagenesis, @entity12116 synthetase (EC 6.3.4.16). These results suggest that, at a constant @entity3104 concentration, the decreased rate of ureagenesis caused by a pH fall in vitro could reflect an @entity520 -induced decline in the concentration of true substrate ( @entity3655 ) for this pathway.

title: Regulation of XXXX synthesis by acid-base balance in vivo: role of @entity3655 concentration.

answer: @entity1133 :: (MESH:D014508,Chemical) :: ['urea']


abstract: OBJECTIVE: Systematic reviews and Meta-analysis were conducted to assess the efficacy and security of adenoidectomy for the treatment of @entity2346 media with effusion in @entity1 . METHOD: Based on the principles and methods of Cochrane systematic reviews, literature was searched in PubMed, Medline, Elisevier, Ovid, CBM, CNKI, @entity3549 and Wanfang datebases. Randomized controlled trials about treatment of @entity2346 media with effusion in @entity1 using adenoidectomy were included. Meta-analysis was performed for the result of homogeneous studies using RevMan 5.2 software. RESULT: Adenoidectomy (combined with myringotomy or puncture) was superior to non-surgical (combined with myringotomy or puncture) treatment in reducing the incidence of @entity697 media and removing the @entity2171 . Adenoidectomy combined with tympanostomy tube was superior to tympanostomy tube alone in the removal of the @entity2171 and improvement of hearing level. Three trials described some postoperative complications including @entity548 , incipient @entity590 , @entity86 and @entity1739 . CONCLUSION: Our research shows a benefit of adenoidectomy in the removal of @entity2171 in @entity1 with OME. Adenoidectomy combined with tympanostomy tube was superior to tympanostomy tube alone in improving hearing level. At present, there is no evidence of serious postoperative complications after adenoidectomy.

title: [A systematic review of adenoidectomy in the treatment of XXXX media with effusion in @entity1 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute otitis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage']

entities_list: @entity1739 :: ('MESH:D014681', 'Disease') :: ['velopharyngeal insufficiency']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative pneumonia']

entities_list: @entity2171 :: ('MESH:D010034', 'Disease') :: ['middle ear effusion']

entities_list: @entity590 :: ('MESH:D008305', 'Disease') :: ['malignant hyperthermia']

answer: @entity2346 :: (MESH:D010031,Disease) :: ['otitis']


abstract: OBJECTIVE: Systematic reviews and Meta-analysis were conducted to assess the efficacy and security of adenoidectomy for the treatment of @entity2346 media with effusion in @entity1 . METHOD: Based on the principles and methods of Cochrane systematic reviews, literature was searched in PubMed, Medline, Elisevier, Ovid, CBM, CNKI, @entity3549 and Wanfang datebases. Randomized controlled trials about treatment of @entity2346 media with effusion in @entity1 using adenoidectomy were included. Meta-analysis was performed for the result of homogeneous studies using RevMan 5.2 software. RESULT: Adenoidectomy (combined with myringotomy or puncture) was superior to non-surgical (combined with myringotomy or puncture) treatment in reducing the incidence of @entity697 media and removing the @entity2171 . Adenoidectomy combined with tympanostomy tube was superior to tympanostomy tube alone in the removal of the @entity2171 and improvement of hearing level. Three trials described some postoperative complications including @entity548 , incipient @entity590 , @entity86 and @entity1739 . CONCLUSION: Our research shows a benefit of adenoidectomy in the removal of @entity2171 in @entity1 with OME. Adenoidectomy combined with tympanostomy tube was superior to tympanostomy tube alone in improving hearing level. At present, there is no evidence of serious postoperative complications after adenoidectomy.

title: [A systematic review of adenoidectomy in the treatment of @entity2346 media with effusion in XXXX ].

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: Clinical presentation of @entity370 varies according to race and geographical area. We describe the clinical spectrum and outcome of @entity370 in Mexican @entity1 compared with other populations. METHODS: We reviewed the medical charts of 21 @entity1 with @entity370 seen at a referral hospital in 1989-2012; organ involvement was assessed using the ACCESS instrument. We compared our results with the ACCESS and Latin American studies. We used descriptive statistics and reported odd ratios with 95% CI. RESULTS AND CONCLUSION: Fifty-two percent were @entity1 ; median age was 31 years; median time to diagnosis, 5.5 months. Frequency of organ involvement was: constitutional symptoms 62%, lungs 66.6%, skin 42.8%, bone marrow 23.4%, lymph node 19%, liver 19%, and eye 19%. After one year of follow-up, 47.5% of @entity1 were asymptomatic without treatment, 38% asymptomatic on treatment, and 14.2% symptomatic on treatment. In our @entity1 , @entity358 was lower (66.6 vs. 94.9%; p = 0.001) and cutaneous (42.8 vs. 15.8%; p = 0.003) and bone marrow (23.4 vs. 4.7%; p = 0.001) were higher than in the ACCESS cohort. Data regarding Latin American populations was scarce. The clinical spectrum of @entity370 in our population differed from other studies, with a higher frequency of @entity370 and less @entity358 .

title: XXXX : a single hospital-based study in a 24-year period.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity370 :: ('MESH:D012507', 'Disease') :: ['cutaneous sarcoidosis', 'sarcoidosis']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary involvement']

answer: @entity370 :: (MESH:D012507,Disease) :: ['Sarcoidosis']


abstract: BACKGROUND: Sleeve gastrectomy (SG) has become a definitive treatment for morbid @entity28 . There is conflicting evidence on the effects of SG on @entity354 ( @entity354 ). OBJECTIVE: The objective of this study was to assess whether taking an aggressive approach to managing @entity425 in @entity1 undergoing SG results in an alteration in @entity354 symptoms. SETTING: Tertiary public hospital and private hospital, Sydney, Australia. METHODS: @entity1 undergoing laparoscopic extended (beginning within 2 cm from pylorus) SG were included. If evidence of @entity425 was present, an anterior hiatal dissection and tight suture repair was performed. If a @entity357 was present, formal repair was undertaken. @entity1 were questioned and scored on preoperative and postoperative reflux symptom frequency and severity, @entity7080 inhibitor (PPI) usage, current weight, and satisfaction. RESULTS: A continuous cohort of 262 @entity1 experienced a significant reduction in heartburn frequency (P = .035) and severity (P = .017). Moderate/severe preoperative reflux (Visick score 3 and 4) often improved whether there was a defect requiring repair or not (no repair P = .02, hiatal suture P = .001, @entity357 repair P<.001). The severity of symptoms also improved (no repair P = 0.005, hiatal suture P<.001, @entity357 repair P< .001). CONCLUSION: Moderate or severe preexisting @entity354 improved for most of our @entity28 @entity1 undergoing an extended SG when hiatal defects were routinely repaired. Moderate to severe preoperative reflux also improved in the average @entity28 @entity1 when there was no hiatal defect to repair.

title: XXXX in laparoscopic sleeve gastrectomy: hiatal findings and their management influence outcome.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['hiatal weakness', 'weakness']

entities_list: @entity357 :: ('MESH:D006551', 'Disease') :: ['hiatus hernia']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux', 'gastroesophageal reflux disease', 'GERD']

answer: @entity354 :: (MESH:D005764,Disease) :: ['Gastroesophageal reflux']


abstract: OBJECTIVE: To evaluate the association of second-hand smoke exposure of pregnant mothers using urine @entity4874 with the neurodevelopment of their @entity1 at 18 months of age in the mother- @entity1 cohort in Crete (Rhea Study). STUDY DESIGN: Selected @entity1 were Greek mothers with singleton pregnancies, had never smoked, and had available urine @entity4874 measurements in pregnancy, and their @entity1 for whom a neurodevelopmental assessment was completed. We performed face-to-face interviews twice during pregnancy and postnatally, and assessed @entity1 's neurodevelopment at 18 months of age using the Bayley Scales of @entity1 and Toddler Development, Third Edition. We used linear regression and generalized additive models. RESULTS: Of 599 mothers, 175 (29%) met the inclusion criteria. Maternal urine @entity4874 levels were low (mean: 10.3 ng/mL, SD: 11.7 ng/mL). Reported passive smoking from different sources was strongly associated with urine @entity4874 levels. A negative association was observed between @entity4874 levels in pregnancy and @entity1 's gross motor function (beta = -3.22 per 10 ng/mL, 95% CI -5.09 to -1.34) after adjusting for factors potentially associated with neurodevelopment; results were similar in both sexes. A negative association was also observed for cognitive and receptive communication scales but the effect was small and not statistically significant. CONCLUSIONS: Maternal exposure during pregnancy to second-hand smoke measured through urine @entity4874 was associated with a decrease in gross motor function among 18-month-old @entity1 , even at low levels of exposure.

title: Prenatal Second-Hand Smoke Exposure Measured with Urine XXXX May Reduce Gross Motor Development at 18 Months of Age.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'Infant', 'child']

entities_list: @entity4874 :: ('MESH:D003367', 'Chemical') :: ['cotinine']

answer: @entity4874 :: (MESH:D003367,Chemical) :: ['Cotinine']


abstract: BACKGROUND: The effect of timing of initiation of concurrent radiation and chemotherapy after surgery on outcome of @entity1 with @entity463 ( @entity463 ) remains unclear. OBJECTIVE: To further explore this issue, we analyzed 4 clinical trials for @entity1 newly diagnosed with @entity463 receiving concurrent and adjuvant @entity2903 . METHODS: The cohort study included 198 adult @entity1 with newly diagnosed supratentorial @entity463 who were enrolled from 2004 to 2010 in 4 clinical trials consisting of radiation plus @entity2903 and an experimental agent. The interval to initiation of therapy was determined from the time of surgical resection. The partitioning deletion/substitution/addition algorithm was used to determine the cutoff points for timing of chemoradiation at which there was a significant difference in @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ). RESULTS: The median wait time between surgery and initiation of concurrent chemoradiation was 29.5 days (range, 7-56 days). A short delay in chemoradiation administration (at 30-34 days) was predictive of prolonged @entity1349 (hazard ratio [HR]: 0.63, P = .03) and prolonged @entity1349 (HR: 0.68, P = .06) compared with early initiation of concurrent chemoradiation (<30 days), after adjusting for protocol and baseline prognostic variables including extent of resection by multivariate analysis. A longer delay to chemoradiation beyond 34 days was not associated with improved @entity1349 or @entity1349 compared with early initiation (HR: 0.94, P = .77 and HR: 0.91, P = .63, respectively). CONCLUSION: A short delay in the start of concurrent chemoradiation is beyond the classic paradigm of 4 weeks post-resection and may be associated with prolonged @entity1349 and @entity1349 . ABBREVIATIONS: @entity463 , glioblastomaKPS, Karnofsky Performance ScoreOS, overall survivalpartDSA, partitioning deletion/substitution/addition algorithmPFS, progression-free survivalRT, radiation therapyTMZ, @entity2903 .

title: The Effect of Timing of Concurrent Chemoradiation in @entity1 With Newly Diagnosed XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'glioblastoma']

entities_list: @entity2903 :: ('MESH:C047246', 'Chemical') :: ['temozolomide']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'PFS', 'overall survival', 'progression-free survival']

answer: @entity463 :: (MESH:D005909,Disease) :: ['Glioblastoma']


abstract: BACKGROUND: The effect of timing of initiation of concurrent radiation and chemotherapy after surgery on outcome of @entity1 with @entity463 ( @entity463 ) remains unclear. OBJECTIVE: To further explore this issue, we analyzed 4 clinical trials for @entity1 newly diagnosed with @entity463 receiving concurrent and adjuvant @entity2903 . METHODS: The cohort study included 198 adult @entity1 with newly diagnosed supratentorial @entity463 who were enrolled from 2004 to 2010 in 4 clinical trials consisting of radiation plus @entity2903 and an experimental agent. The interval to initiation of therapy was determined from the time of surgical resection. The partitioning deletion/substitution/addition algorithm was used to determine the cutoff points for timing of chemoradiation at which there was a significant difference in @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ). RESULTS: The median wait time between surgery and initiation of concurrent chemoradiation was 29.5 days (range, 7-56 days). A short delay in chemoradiation administration (at 30-34 days) was predictive of prolonged @entity1349 (hazard ratio [HR]: 0.63, P = .03) and prolonged @entity1349 (HR: 0.68, P = .06) compared with early initiation of concurrent chemoradiation (<30 days), after adjusting for protocol and baseline prognostic variables including extent of resection by multivariate analysis. A longer delay to chemoradiation beyond 34 days was not associated with improved @entity1349 or @entity1349 compared with early initiation (HR: 0.94, P = .77 and HR: 0.91, P = .63, respectively). CONCLUSION: A short delay in the start of concurrent chemoradiation is beyond the classic paradigm of 4 weeks post-resection and may be associated with prolonged @entity1349 and @entity1349 . ABBREVIATIONS: @entity463 , glioblastomaKPS, Karnofsky Performance ScoreOS, overall survivalpartDSA, partitioning deletion/substitution/addition algorithmPFS, progression-free survivalRT, radiation therapyTMZ, @entity2903 .

title: The Effect of Timing of Concurrent Chemoradiation in XXXX With Newly Diagnosed @entity463 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: @entity2858 -specific CD4+ and CD8+ T lymphocytes are important for @entity2858 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/ @entity4453 , Pol/RT, @entity4483 and Gag/ @entity14848 ) formulated in AS01 Adjuvant System, and was shown to induce F4-specific polyfunctional CD4+ T-cell responses in @entity1 . While replication-incompetent recombinant HIV-1/SIV antigen-expressing @entity1 adenoviral vectors can elicit high-frequency antigen-specific CD8+ T-cell responses, their use is hampered by widespread pre-existing immunity to @entity1 serotypes. Non- @entity1 adenovirus serotypes associated with lower prevalence may offer an alternative strategy. We evaluated the immunogenicity of AdC7-GRN ('A'), a recombinant @entity831 adenovirus type 7 vector expressing clade B Gag, RT and @entity4483 , and F4/AS01 ('P'), when delivered intramuscularly in homologous (PP or AA) and heterologous (AAPP or PPAA) prime-boost regimens, in macaques and @entity19 . Vaccine-induced HIV-1-antigen-specific T cells in peripheral blood (macaques), liver, spleen, and @entity790 ( @entity19 ) were characterized by intracellular cytokine staining. Vaccine-specific IgG antibodies (macaques) were detected using ELISA. In macaques, only the heterologous prime-boost regimens induced polyfunctional, persistent and balanced CD4+ and CD8+ T-cell responses specific to each HIV-1 vaccine antigen. AdC7-GRN priming increased the polyfunctionality of F4/AS01-induced CD4+ T cells. Approximately 50% of AdC7-GRN-induced memory CD8+ T cells exhibited an effector-memory phenotype. HIV-1-specific antibodies were detected with each regimen. In mice, antigen-specific CD4+ and CD8+ T-cell responses were detected in the mucosal and systemic anatomical compartments assessed. When administered in heterologous prime-boost regimens, AdC7-GRN and F4/AS01 candidate vaccines acted complementarily in inducing potent and persistent peripheral blood @entity2858 -specific CD4+ and CD8+ T-cell responses and antibodies in macaques. Besides, adenoviral vector priming modulated the cytokine-expression profile of the protein-induced CD4+ T cells. Each regimen induced @entity2858 -specific T-cell responses in systemic/local tissues in @entity19 . This suggests that prime-boost regimens combining adjuvanted protein and low-seroprevalent @entity831 adenoviral vectors represent an attractive vaccination strategy for clinical evaluation.

title: Heterologous Prime-Boost Regimens with a Recombinant XXXX Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional @entity2858 -Specific T-Cell Responses in Macaques.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity831 :: ('9598', 'Species') :: ['chimpanzee']

entities_list: @entity790 :: ('MESH:D014564', 'Disease') :: ['intestinal and genital mucosa']

answer: @entity831 :: (9598,Species) :: ['Chimpanzee']


abstract: UNASSIGNED: @entity2858 -specific CD4+ and CD8+ T lymphocytes are important for @entity2858 replication control. F4/AS01 consists of F4 recombinant fusion protein (containing clade B Gag/ @entity4453 , Pol/RT, @entity4483 and Gag/ @entity14848 ) formulated in AS01 Adjuvant System, and was shown to induce F4-specific polyfunctional CD4+ T-cell responses in @entity1 . While replication-incompetent recombinant HIV-1/SIV antigen-expressing @entity1 adenoviral vectors can elicit high-frequency antigen-specific CD8+ T-cell responses, their use is hampered by widespread pre-existing immunity to @entity1 serotypes. Non- @entity1 adenovirus serotypes associated with lower prevalence may offer an alternative strategy. We evaluated the immunogenicity of AdC7-GRN ('A'), a recombinant @entity831 adenovirus type 7 vector expressing clade B Gag, RT and @entity4483 , and F4/AS01 ('P'), when delivered intramuscularly in homologous (PP or AA) and heterologous (AAPP or PPAA) prime-boost regimens, in macaques and @entity19 . Vaccine-induced HIV-1-antigen-specific T cells in peripheral blood (macaques), liver, spleen, and @entity790 ( @entity19 ) were characterized by intracellular cytokine staining. Vaccine-specific IgG antibodies (macaques) were detected using ELISA. In macaques, only the heterologous prime-boost regimens induced polyfunctional, persistent and balanced CD4+ and CD8+ T-cell responses specific to each HIV-1 vaccine antigen. AdC7-GRN priming increased the polyfunctionality of F4/AS01-induced CD4+ T cells. Approximately 50% of AdC7-GRN-induced memory CD8+ T cells exhibited an effector-memory phenotype. HIV-1-specific antibodies were detected with each regimen. In mice, antigen-specific CD4+ and CD8+ T-cell responses were detected in the mucosal and systemic anatomical compartments assessed. When administered in heterologous prime-boost regimens, AdC7-GRN and F4/AS01 candidate vaccines acted complementarily in inducing potent and persistent peripheral blood @entity2858 -specific CD4+ and CD8+ T-cell responses and antibodies in macaques. Besides, adenoviral vector priming modulated the cytokine-expression profile of the protein-induced CD4+ T cells. Each regimen induced @entity2858 -specific T-cell responses in systemic/local tissues in @entity19 . This suggests that prime-boost regimens combining adjuvanted protein and low-seroprevalent @entity831 adenoviral vectors represent an attractive vaccination strategy for clinical evaluation.

title: Heterologous Prime-Boost Regimens with a Recombinant @entity831 Adenoviral Vector and Adjuvanted F4 Protein Elicit Polyfunctional XXXX -Specific T-Cell Responses in Macaques.

answer: @entity2858 :: (11676,Species) :: ['HIV-1']


abstract: UNASSIGNED: Differentiation of infectious causes in severely ill @entity1 is essential but challenging in sub- Saharan Africa. The aim of the study was to determine clinical indicators that are able to identify @entity2348 in @entity3964 infected @entity1 in rural Ghana. In total, 1,915 severely ill @entity1 below the age of 15 years were recruited at Agogo Presbyterian Hospital in Ghana between May 2007 and February 2011. In 771 (40%) of the @entity1 @entity311 parasites were detected. This group was analyzed for indicators of @entity2348 using bivariate and multivariate regression analyses with 24 socio-economic variables, 16 terms describing medical history and anthropometrical information and 68 variables describing clinical symptoms. The variables were tested for sensitivity, specificity, positive predictive value and negative predictive value. In 46 (6.0%) of the @entity1 with @entity281 , @entity2348 was detected. The most frequent pathogens were non-typhoid salmonellae (45.7%), followed by Streptococcus spp. (13.0%). Coughing, @entity2700 , @entity381 , severe @entity417 and @entity491 were positively associated with @entity2259 . Domestic hygiene and exclusive breastfeeding is negatively associated with @entity2259 . In cases of high @entity5895 (>10,000/ l), a significant association with @entity2259 was found for @entity381 (OR 8.8; CI 1.6-48.9), @entity2700 (OR 18.2; CI 2.0-166.0) and coughing (OR 9.0; CI 0.7-118.6). In @entity1 with low @entity5895 , associations with @entity2259 were found for @entity391 (OR 4.7; CI 1.4-15.8), severe @entity417 (OR 3.3; CI 1.0-11.1) and @entity491 (OR 6.8 CI 1.9-24.2). Clinical signs of impaired microcirculation were negatively associated with @entity2259 . @entity2756 achieved best coverage of isolated pathogens. The results demonstrate the limitation of clinical symptoms to determine @entity2348 in @entity3964 infected @entity1 . Best clinical indicators are dependent on the @entity5895 level. Even with a moderate sensitivity of >60%, only low positive predictive values can be obtained due to low prevalence of @entity2259 . Rapid testing for distinguishing @entity5895 and @entity2259 is essential.

title: Clinical Indicators for @entity2348 in Ghanaian @entity1 with XXXX Infection.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['Ceftriaxone']

entities_list: @entity2700 :: ('MESH:D003681', 'Disease') :: ['dehydration']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial co-infections', 'bacterial co-infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['malaria infection']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity5895 :: ('MESH:D018512', 'Disease') :: ['parasitemia']

entities_list: @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']

entities_list: @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis']

answer: @entity3964 :: (5833,Species) :: ['P. falciparum']


abstract: UNASSIGNED: Differentiation of infectious causes in severely ill @entity1 is essential but challenging in sub- Saharan Africa. The aim of the study was to determine clinical indicators that are able to identify @entity2348 in @entity3964 infected @entity1 in rural Ghana. In total, 1,915 severely ill @entity1 below the age of 15 years were recruited at Agogo Presbyterian Hospital in Ghana between May 2007 and February 2011. In 771 (40%) of the @entity1 @entity311 parasites were detected. This group was analyzed for indicators of @entity2348 using bivariate and multivariate regression analyses with 24 socio-economic variables, 16 terms describing medical history and anthropometrical information and 68 variables describing clinical symptoms. The variables were tested for sensitivity, specificity, positive predictive value and negative predictive value. In 46 (6.0%) of the @entity1 with @entity281 , @entity2348 was detected. The most frequent pathogens were non-typhoid salmonellae (45.7%), followed by Streptococcus spp. (13.0%). Coughing, @entity2700 , @entity381 , severe @entity417 and @entity491 were positively associated with @entity2259 . Domestic hygiene and exclusive breastfeeding is negatively associated with @entity2259 . In cases of high @entity5895 (>10,000/ l), a significant association with @entity2259 was found for @entity381 (OR 8.8; CI 1.6-48.9), @entity2700 (OR 18.2; CI 2.0-166.0) and coughing (OR 9.0; CI 0.7-118.6). In @entity1 with low @entity5895 , associations with @entity2259 were found for @entity391 (OR 4.7; CI 1.4-15.8), severe @entity417 (OR 3.3; CI 1.0-11.1) and @entity491 (OR 6.8 CI 1.9-24.2). Clinical signs of impaired microcirculation were negatively associated with @entity2259 . @entity2756 achieved best coverage of isolated pathogens. The results demonstrate the limitation of clinical symptoms to determine @entity2348 in @entity3964 infected @entity1 . Best clinical indicators are dependent on the @entity5895 level. Even with a moderate sensitivity of >60%, only low positive predictive values can be obtained due to low prevalence of @entity2259 . Rapid testing for distinguishing @entity5895 and @entity2259 is essential.

title: Clinical Indicators for XXXX in Ghanaian @entity1 with @entity3964 Infection.

answer: @entity2348 :: (MESH:D001424,Disease) :: ['Bacterial Co-Infection']


abstract: UNASSIGNED: Differentiation of infectious causes in severely ill @entity1 is essential but challenging in sub- Saharan Africa. The aim of the study was to determine clinical indicators that are able to identify @entity2348 in @entity3964 infected @entity1 in rural Ghana. In total, 1,915 severely ill @entity1 below the age of 15 years were recruited at Agogo Presbyterian Hospital in Ghana between May 2007 and February 2011. In 771 (40%) of the @entity1 @entity311 parasites were detected. This group was analyzed for indicators of @entity2348 using bivariate and multivariate regression analyses with 24 socio-economic variables, 16 terms describing medical history and anthropometrical information and 68 variables describing clinical symptoms. The variables were tested for sensitivity, specificity, positive predictive value and negative predictive value. In 46 (6.0%) of the @entity1 with @entity281 , @entity2348 was detected. The most frequent pathogens were non-typhoid salmonellae (45.7%), followed by Streptococcus spp. (13.0%). Coughing, @entity2700 , @entity381 , severe @entity417 and @entity491 were positively associated with @entity2259 . Domestic hygiene and exclusive breastfeeding is negatively associated with @entity2259 . In cases of high @entity5895 (>10,000/ l), a significant association with @entity2259 was found for @entity381 (OR 8.8; CI 1.6-48.9), @entity2700 (OR 18.2; CI 2.0-166.0) and coughing (OR 9.0; CI 0.7-118.6). In @entity1 with low @entity5895 , associations with @entity2259 were found for @entity391 (OR 4.7; CI 1.4-15.8), severe @entity417 (OR 3.3; CI 1.0-11.1) and @entity491 (OR 6.8 CI 1.9-24.2). Clinical signs of impaired microcirculation were negatively associated with @entity2259 . @entity2756 achieved best coverage of isolated pathogens. The results demonstrate the limitation of clinical symptoms to determine @entity2348 in @entity3964 infected @entity1 . Best clinical indicators are dependent on the @entity5895 level. Even with a moderate sensitivity of >60%, only low positive predictive values can be obtained due to low prevalence of @entity2259 . Rapid testing for distinguishing @entity5895 and @entity2259 is essential.

title: Clinical Indicators for @entity2348 in Ghanaian XXXX with @entity3964 Infection.

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: OBJECTIVE: @entity14 is an important cause of @entity204 in @entity29 , thus requiring surveillance for @entity1141 in long-standing @entity31 ( @entity31 ). Females show a lower incidence probably related to hormonal factors; therefore, a role of @entity172 receptors (ERs) has been supposed in @entity189 ( @entity189 ) development. Our aim was to identify @entity1783 /alpha expression in long-lasting pancolitis through each grade of @entity1141 to @entity189 and, furthermore, to investigate the simultaneous epithelial apoptosis/proliferation. MATERIALS AND METHODS: Forty-eight @entity1 affected by long-lasting pancolitis were retrospectively investigated. Samples were divided into four groups: @entity31 , low-grade @entity1141 /high-grade @entity1141 ( @entity31 -HGD), and @entity189 . Normal colon samples were used as controls. @entity1783 , @entity1782 , Ki-67, and TUNEL expression (labeling/H index) were evaluated by immunohistochemistry. RESULTS: @entity1783 expression revealed an impressive reduction in @entity189 (10.4    5.1; p < 0.001) compared to controls and @entity31 (34.3    3.1 and 26.8    7.8, respectively), meanwhile @entity1783 level in LGD (29.4    3.7) was comparable to @entity31 . As far @entity1783 / @entity1782 mean value ratio revealed a progressive reduction. Ki67 demonstrated a progressive significant increase from @entity31 until @entity189 (37.9    6.4 < 45.7    6.2 < 60.6    5.2 < 71.1    5.1; p < 0.001). Apoptotic index (TUNEL) revealed a strong fall in @entity31 -HGD and @entity189 . CONCLUSIONS: @entity1783 fall could be considered as a biomarker of @entity31 progression. It occurs in HGD and overt @entity5 , while in LGD shows a normal expression. At the moment, we are unable to use this tool in the clinical practice to predict @entity5 progression, but it would be appropriate to encourage ER expression investigations in large samples for the interesting perspectives of application.

title: The sharp decline of beta XXXX receptors expression in long-lasting @entity189 .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia', 'tumor']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC', 'UC-dysplasia']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['CAC', 'carcinoma', 'carcinoma-associated colitis']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel diseases']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal carcinoma']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity172 :: (MESH:D004967,Chemical) :: ['estrogen']


abstract: OBJECTIVE: @entity14 is an important cause of @entity204 in @entity29 , thus requiring surveillance for @entity1141 in long-standing @entity31 ( @entity31 ). Females show a lower incidence probably related to hormonal factors; therefore, a role of @entity172 receptors (ERs) has been supposed in @entity189 ( @entity189 ) development. Our aim was to identify @entity1783 /alpha expression in long-lasting pancolitis through each grade of @entity1141 to @entity189 and, furthermore, to investigate the simultaneous epithelial apoptosis/proliferation. MATERIALS AND METHODS: Forty-eight @entity1 affected by long-lasting pancolitis were retrospectively investigated. Samples were divided into four groups: @entity31 , low-grade @entity1141 /high-grade @entity1141 ( @entity31 -HGD), and @entity189 . Normal colon samples were used as controls. @entity1783 , @entity1782 , Ki-67, and TUNEL expression (labeling/H index) were evaluated by immunohistochemistry. RESULTS: @entity1783 expression revealed an impressive reduction in @entity189 (10.4    5.1; p < 0.001) compared to controls and @entity31 (34.3    3.1 and 26.8    7.8, respectively), meanwhile @entity1783 level in LGD (29.4    3.7) was comparable to @entity31 . As far @entity1783 / @entity1782 mean value ratio revealed a progressive reduction. Ki67 demonstrated a progressive significant increase from @entity31 until @entity189 (37.9    6.4 < 45.7    6.2 < 60.6    5.2 < 71.1    5.1; p < 0.001). Apoptotic index (TUNEL) revealed a strong fall in @entity31 -HGD and @entity189 . CONCLUSIONS: @entity1783 fall could be considered as a biomarker of @entity31 progression. It occurs in HGD and overt @entity5 , while in LGD shows a normal expression. At the moment, we are unable to use this tool in the clinical practice to predict @entity5 progression, but it would be appropriate to encourage ER expression investigations in large samples for the interesting perspectives of application.

title: The sharp decline of beta @entity172 receptors expression in long-lasting XXXX .

answer: @entity189 :: (MESH:D002277,Disease) :: ['ulcerative-associated carcinoma']


abstract: @entity235 cranial cruciate @entity397 (CCLR) is the most common cause of pelvic limb lameness in @entity235 . CCLR results in palpable stifle instability secondary to cranial translation of the tibial relative to the femur, and it can be diagnosed during the orthopedic exam using the @entity129 ( @entity129 ) and tibial compression test (TCT). Accurate diagnosis of CCLR depends on the efficacy in performing these tests. In this study, two three-dimensional @entity235 pelvic limb models were developed: one simulating a normal stifle and one simulating CCLR. Thirty-eight veterinary student @entity1 answered questionnaires and performed both the @entity129 and TCT on a randomly assigned model. Twenty-one @entity1 also manipulated the models one week later to assess skill retention in the short term. Mean levels of reported confidence in diagnosing CCLR and finding anatomic landmarks for @entity129 /TCT were significantly higher following model manipulation. Nearly all @entity1 reported that they desired a model for teaching the diagnosis of CCLR. Most @entity1 (92.5%) felt that the tested model would be useful for teaching CCLR diagnosis. Accuracy in diagnosing CCLR with the TCT significantly improved over time. @entity1 response indicated that while the tested model was effective and desirable, an ideal model would be more durable and lifelike. Further studies are needed to evaluate the developed models' effectiveness for teaching CCLR diagnosis compared to traditional teaching methods.

title: Development and Efficacy of a XXXX Pelvic Limb Model Used to Teach the Cranial Drawer and Tibial Compression Tests in the Stifle Joint.

entities_list: @entity235 :: ('9615', 'Species') :: ['canine', 'Canine', 'dogs']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participant']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ligament rupture']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['CDT', 'cranial drawer test']

answer: @entity235 :: (9615,Species) :: ['Canine']


abstract: UNASSIGNED: Oxidative stress plays a pivotal role in the pathophysiology of @entity2316 , and the @entity1110 ( @entity1110 ) oxidase system is an important source of reactive @entity26 species in @entity1602 conditions in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, is increased in @entity1 with @entity2316 . We investigated associations of variants in the @entity1115 gene, encoding the regulatory subunit @entity9822 (phox) of @entity1110 oxidase, with @entity2316 and plasma AOPP and @entity3335 ( @entity3335 ) concentrations in type 1 @entity6 @entity1 . Seven SNPs in the @entity1115 region were analyzed in 1357 Caucasian subjects with type 1 @entity6 from the SURGENE (n=340), GENEDIAB (n=444), and GENESIS (n=573) cohorts. Duration of follow-up was 10, 9, and 6 years, respectively. Cox proportional hazards and logistic regression analyses were used to estimate hazard ratios (HR) or odds ratios (OR) for incidence and prevalence of @entity2316 . The major G-allele of @entity72144 was associated with the incidence of renal events defined as new cases of microalbuminuria or the progression to a more severe stage of @entity8 during follow-up (HR 1.59, 95% CI 1.17-2.18, P=0.003) in SURGENE. The same allele was associated with established/advanced @entity8 (OR 1.52, 95% CI 1.22-1.92, P=0.0001) and with the incidence of @entity454 ( @entity454 ) (HR 2.01, 95% CI 1.30-3.24, P=0.001) in GENEDIAB/GENESIS pooled studies. The risk allele was also associated with higher plasma AOPP concentration in subsets of SURGENE and GENEDIAB, with higher plasma @entity3335 concentration in a subset of GENEDIAB, and with lower estimated glomerular filtration rate (eGFR) in the three cohorts. In conclusion, a functional variant in the promoter of the @entity1115 gene was associated with lower eGFR and with prevalence and incidence of @entity2316 and @entity454 in type 1 @entity6 @entity1 . These results are consistent with a role for @entity1110 oxidase in the pathophysiology of @entity8 of @entity6 .

title: Allelic variations in the @entity1115 gene of @entity1110 oxidase and risk of XXXX in @entity1 with type 1 @entity6 .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'kidney complications']

entities_list: @entity3335 :: ('4353', 'Gene') :: ['MPO', 'myeloperoxidase']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1110 :: ('MESH:D009249', 'Chemical') :: ['nicotinamide adenine dinucleotide phosphate', 'NADPH']

entities_list: @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease', 'ESRD']

answer: @entity8 :: (MESH:D007674,Disease) :: ['kidney complications']


abstract: UNASSIGNED: Oxidative stress plays a pivotal role in the pathophysiology of @entity2316 , and the @entity1110 ( @entity1110 ) oxidase system is an important source of reactive @entity26 species in @entity1602 conditions in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, is increased in @entity1 with @entity2316 . We investigated associations of variants in the @entity1115 gene, encoding the regulatory subunit @entity9822 (phox) of @entity1110 oxidase, with @entity2316 and plasma AOPP and @entity3335 ( @entity3335 ) concentrations in type 1 @entity6 @entity1 . Seven SNPs in the @entity1115 region were analyzed in 1357 Caucasian subjects with type 1 @entity6 from the SURGENE (n=340), GENEDIAB (n=444), and GENESIS (n=573) cohorts. Duration of follow-up was 10, 9, and 6 years, respectively. Cox proportional hazards and logistic regression analyses were used to estimate hazard ratios (HR) or odds ratios (OR) for incidence and prevalence of @entity2316 . The major G-allele of @entity72144 was associated with the incidence of renal events defined as new cases of microalbuminuria or the progression to a more severe stage of @entity8 during follow-up (HR 1.59, 95% CI 1.17-2.18, P=0.003) in SURGENE. The same allele was associated with established/advanced @entity8 (OR 1.52, 95% CI 1.22-1.92, P=0.0001) and with the incidence of @entity454 ( @entity454 ) (HR 2.01, 95% CI 1.30-3.24, P=0.001) in GENEDIAB/GENESIS pooled studies. The risk allele was also associated with higher plasma AOPP concentration in subsets of SURGENE and GENEDIAB, with higher plasma @entity3335 concentration in a subset of GENEDIAB, and with lower estimated glomerular filtration rate (eGFR) in the three cohorts. In conclusion, a functional variant in the promoter of the @entity1115 gene was associated with lower eGFR and with prevalence and incidence of @entity2316 and @entity454 in type 1 @entity6 @entity1 . These results are consistent with a role for @entity1110 oxidase in the pathophysiology of @entity8 of @entity6 .

title: Allelic variations in the XXXX gene of @entity1110 oxidase and risk of @entity8 in @entity1 with type 1 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity1115 :: (1535,Gene) :: ['CYBA']


abstract: UNASSIGNED: Oxidative stress plays a pivotal role in the pathophysiology of @entity2316 , and the @entity1110 ( @entity1110 ) oxidase system is an important source of reactive @entity26 species in @entity1602 conditions in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, is increased in @entity1 with @entity2316 . We investigated associations of variants in the @entity1115 gene, encoding the regulatory subunit @entity9822 (phox) of @entity1110 oxidase, with @entity2316 and plasma AOPP and @entity3335 ( @entity3335 ) concentrations in type 1 @entity6 @entity1 . Seven SNPs in the @entity1115 region were analyzed in 1357 Caucasian subjects with type 1 @entity6 from the SURGENE (n=340), GENEDIAB (n=444), and GENESIS (n=573) cohorts. Duration of follow-up was 10, 9, and 6 years, respectively. Cox proportional hazards and logistic regression analyses were used to estimate hazard ratios (HR) or odds ratios (OR) for incidence and prevalence of @entity2316 . The major G-allele of @entity72144 was associated with the incidence of renal events defined as new cases of microalbuminuria or the progression to a more severe stage of @entity8 during follow-up (HR 1.59, 95% CI 1.17-2.18, P=0.003) in SURGENE. The same allele was associated with established/advanced @entity8 (OR 1.52, 95% CI 1.22-1.92, P=0.0001) and with the incidence of @entity454 ( @entity454 ) (HR 2.01, 95% CI 1.30-3.24, P=0.001) in GENEDIAB/GENESIS pooled studies. The risk allele was also associated with higher plasma AOPP concentration in subsets of SURGENE and GENEDIAB, with higher plasma @entity3335 concentration in a subset of GENEDIAB, and with lower estimated glomerular filtration rate (eGFR) in the three cohorts. In conclusion, a functional variant in the promoter of the @entity1115 gene was associated with lower eGFR and with prevalence and incidence of @entity2316 and @entity454 in type 1 @entity6 @entity1 . These results are consistent with a role for @entity1110 oxidase in the pathophysiology of @entity8 of @entity6 .

title: Allelic variations in the @entity1115 gene of XXXX oxidase and risk of @entity8 in @entity1 with type 1 @entity6 .

answer: @entity1110 :: (MESH:D009249,Chemical) :: ['NADPH']


abstract: UNASSIGNED: Oxidative stress plays a pivotal role in the pathophysiology of @entity2316 , and the @entity1110 ( @entity1110 ) oxidase system is an important source of reactive @entity26 species in @entity1602 conditions in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, is increased in @entity1 with @entity2316 . We investigated associations of variants in the @entity1115 gene, encoding the regulatory subunit @entity9822 (phox) of @entity1110 oxidase, with @entity2316 and plasma AOPP and @entity3335 ( @entity3335 ) concentrations in type 1 @entity6 @entity1 . Seven SNPs in the @entity1115 region were analyzed in 1357 Caucasian subjects with type 1 @entity6 from the SURGENE (n=340), GENEDIAB (n=444), and GENESIS (n=573) cohorts. Duration of follow-up was 10, 9, and 6 years, respectively. Cox proportional hazards and logistic regression analyses were used to estimate hazard ratios (HR) or odds ratios (OR) for incidence and prevalence of @entity2316 . The major G-allele of @entity72144 was associated with the incidence of renal events defined as new cases of microalbuminuria or the progression to a more severe stage of @entity8 during follow-up (HR 1.59, 95% CI 1.17-2.18, P=0.003) in SURGENE. The same allele was associated with established/advanced @entity8 (OR 1.52, 95% CI 1.22-1.92, P=0.0001) and with the incidence of @entity454 ( @entity454 ) (HR 2.01, 95% CI 1.30-3.24, P=0.001) in GENEDIAB/GENESIS pooled studies. The risk allele was also associated with higher plasma AOPP concentration in subsets of SURGENE and GENEDIAB, with higher plasma @entity3335 concentration in a subset of GENEDIAB, and with lower estimated glomerular filtration rate (eGFR) in the three cohorts. In conclusion, a functional variant in the promoter of the @entity1115 gene was associated with lower eGFR and with prevalence and incidence of @entity2316 and @entity454 in type 1 @entity6 @entity1 . These results are consistent with a role for @entity1110 oxidase in the pathophysiology of @entity8 of @entity6 .

title: Allelic variations in the @entity1115 gene of @entity1110 oxidase and risk of @entity8 in @entity1 with type 1 XXXX .

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: UNASSIGNED: Oxidative stress plays a pivotal role in the pathophysiology of @entity2316 , and the @entity1110 ( @entity1110 ) oxidase system is an important source of reactive @entity26 species in @entity1602 conditions in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, is increased in @entity1 with @entity2316 . We investigated associations of variants in the @entity1115 gene, encoding the regulatory subunit @entity9822 (phox) of @entity1110 oxidase, with @entity2316 and plasma AOPP and @entity3335 ( @entity3335 ) concentrations in type 1 @entity6 @entity1 . Seven SNPs in the @entity1115 region were analyzed in 1357 Caucasian subjects with type 1 @entity6 from the SURGENE (n=340), GENEDIAB (n=444), and GENESIS (n=573) cohorts. Duration of follow-up was 10, 9, and 6 years, respectively. Cox proportional hazards and logistic regression analyses were used to estimate hazard ratios (HR) or odds ratios (OR) for incidence and prevalence of @entity2316 . The major G-allele of @entity72144 was associated with the incidence of renal events defined as new cases of microalbuminuria or the progression to a more severe stage of @entity8 during follow-up (HR 1.59, 95% CI 1.17-2.18, P=0.003) in SURGENE. The same allele was associated with established/advanced @entity8 (OR 1.52, 95% CI 1.22-1.92, P=0.0001) and with the incidence of @entity454 ( @entity454 ) (HR 2.01, 95% CI 1.30-3.24, P=0.001) in GENEDIAB/GENESIS pooled studies. The risk allele was also associated with higher plasma AOPP concentration in subsets of SURGENE and GENEDIAB, with higher plasma @entity3335 concentration in a subset of GENEDIAB, and with lower estimated glomerular filtration rate (eGFR) in the three cohorts. In conclusion, a functional variant in the promoter of the @entity1115 gene was associated with lower eGFR and with prevalence and incidence of @entity2316 and @entity454 in type 1 @entity6 @entity1 . These results are consistent with a role for @entity1110 oxidase in the pathophysiology of @entity8 of @entity6 .

title: Allelic variations in the @entity1115 gene of @entity1110 oxidase and risk of @entity8 in XXXX with type 1 @entity6 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Predictive models are an integral part of current clinical practice and help determine optimal treatment strategies for individual @entity1 . A drawback is that covariates are assumed to have constant effects on @entity1349 ( @entity1349 ), when in fact, these effects may change during follow-up (FU). Furthermore, @entity0 ( @entity0 ) @entity1 may experience events that alter their prognosis from that time onwards. We investigated the 'dynamic' effects of different covariates on @entity1349 and developed a nomogram to calculate 5-year dynamic @entity1349 (DOS) probability at different prediction timepoints (tP) during FU. METHODS: Dutch and Belgian postmenopausal, endocrine-sensitive, early @entity0 @entity1 enrolled in the TEAM trial were included. We assessed time-varying effects of specific covariates and obtained 5-year DOS predictions using a proportional baselines landmark supermodel. Covariates included age, histological grade, @entity5282 and @entity1722 status, T- and N-stage, locoregional recurrence (LRR), distant recurrence, and treatment compliance. A nomogram was designed to calculate 5-year DOS based on individual characteristics. RESULTS: A total of 2602 @entity1 were included (mean FU 6.2 years). N-stage, LRR, and @entity1722 status demonstrated time-varying effects on 5-year DOS. Hazard ratio (HR) functions for LRR, high-risk N-stage (N2/3), and @entity1722 positivity were HR = (8.427 * 0.583[Formula: see text], HR = (3.621 * 0.816[Formula: see text], and HR = (1.235 * 0.851[Formula: see text], respectively. Treatment discontinuation was associated with a higher mortality risk, but without a time-varying effect [HR 1.263 (0.867-1.841)]. All other covariates were time-constant. DISCUSSION: The current nomogram accounts for elapsed time since starting adjuvant endocrine treatment and optimizes prediction of individual 5-year DOS during FU for postmenopausal, endocrine-sensitive @entity0 @entity1 . The nomogram can facilitate in determining whether further therapy will benefit an individual @entity1 , although validation in an independent dataset is still needed.

title: Dynamic prediction in XXXX : proving feasibility in clinical practice using the TEAM trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'BC']

entities_list: @entity5282 :: ('3164', 'Gene') :: ['hormone receptor']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: In western literature, the oldest description of symptoms of @entity1005 , an @entity148 , is seen in Homer's Iliad written around 720 BC. According to Shay, Achilles was suffering from symptoms of @entity1005 . However, in the Indian literature it was mentioned around 5000 BC. The description of a @entity1005 -like syndrome is seen in the Ramayana, although it was not described as @entity1005 or by any other similar name. Ravana's brother Marrich was having symptoms of @entity1005 after he was grievously hurt by Lord Rama's arrow and was almost dead. This traumatic event threatened his physical integrity. He developed all the symptoms of @entity1005 , like hyper-arousal, re-experiencing the events and avoidance. He also gave up his natural work of harassing the monk and got engaged in meditation and austerities. His symptoms lasted for many years till Lord Rama killed him, while he was masquerading as a golden deer to deceive Sita. In another ancient epic Shrimad Bhagavatam, Maharshi Ved Vyasa described the symptoms of @entity148 ( @entity148 ). The demon King Kansha developed @entity148 -like symptoms, when Lord Krishna killed all his demons and threatened to kill him. He developed symptoms of @entity148 , like excessive worry about the attack from his arch foe Krishna, difficulty in concentration and difficulty in falling asleep. Like Marrich, the symptoms of Kansha also lasted until Lord Krishna killed him.

title: XXXX in ancient Indian literature.

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['GAD', 'anxiety group of disorder', 'Generalized Anxiety Disorder']

answer: @entity148 :: (MESH:D001008,Disease) :: ['Anxiety disorders']


abstract: BACKGROUND CONTEXT: A subgroup of @entity1 with acute to subacute @entity1643 ( @entity1643 ) presenting with trunk movement control deficits, @entity158 provocation with segmental testing, and segmental @entity8018 have been clinically identified as having @entity717 ( @entity717 ) of the trunk. It is hypothesized that these @entity1 have proprioceptive, postural, and movement @entity73 of the trunk associated with @entity1643 . Although trunk @entity73 have been identified in @entity1 with chronic @entity1643 , they have not been investigated in this subgroup or closer to symptom onset. PURPOSE: The purpose of the study was to identify trunk motor control (postural control and movement precision) impairments in a subgroup of @entity1 with acute to subacute @entity1643 who have been clinically identified to have @entity717 and determine association of these impairments with @entity158 and fear of movement. STUDY DESIGN/SETTING: The study design includes observational design, university biomechanics laboratory, and clinical practice. @entity1 SAMPLE: Thirty-three @entity1 with acute to subacute @entity1643 presenting with trunk @entity717 and 33 healthy controls matched with gender, age, and body mass index were identified. OUTCOME MEASURES: Self-report measures included Numeric Pain Rating Scale, Oswestry Disability Index Questionnaire, and Fear-Avoidance Beliefs Questionnaire and physiologic measures included postural control and movement precision. METHODS: Center-of-pressure movement was measured while subjects attempted to volitionally control trunk posture and movement while sitting on a platform with a hemisphere mounted underneath. This created an unstable surface that required coordinated trunk control to maintain an upright seated posture. Postural control was tested using eyes-open and -closed balance protocols. Movement precision was tested with a dynamic control test requiring movement of the center of pressure along a discrete path. Group trunk motor control performance was compared with analysis of variance and t test. Performance association with @entity158 and fear of movement were assessed with Pearson correlations. RESULTS: @entity1 ' postural control in the eyes-closed condition (p=.02) and movement precision (p=.04) were significantly impaired compared with healthy controls, with moderate-to-large group difference effect sizes. These trunk motor @entity73 were not significantly associated with the @entity1 self-reported @entity158 characteristics and fear of movement. CONCLUSIONS: @entity1 with clinical identification of trunk @entity717 demonstrated decreased trunk motor control, suggesting that @entity3325 , or central processing occur early in the back @entity158 episode. This information may help to guide interventions to address these specific limitations, improving delivery of care.

title: Trunk motor control deficits in acute and subacute XXXX are not associated with @entity158 or fear of movement.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENT', 'Patients', 'patients']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain', 'LBP']

entities_list: @entity3325 :: ('MESH:D020886', 'Disease') :: ['impairments in proprioception, motor output']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['control impairments']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['MCIs', 'movement coordination impairments']

entities_list: @entity8018 :: ('MESH:C536196', 'Disease') :: ['hypermobility']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['low back pain']


abstract: BACKGROUND CONTEXT: A subgroup of @entity1 with acute to subacute @entity1643 ( @entity1643 ) presenting with trunk movement control deficits, @entity158 provocation with segmental testing, and segmental @entity8018 have been clinically identified as having @entity717 ( @entity717 ) of the trunk. It is hypothesized that these @entity1 have proprioceptive, postural, and movement @entity73 of the trunk associated with @entity1643 . Although trunk @entity73 have been identified in @entity1 with chronic @entity1643 , they have not been investigated in this subgroup or closer to symptom onset. PURPOSE: The purpose of the study was to identify trunk motor control (postural control and movement precision) impairments in a subgroup of @entity1 with acute to subacute @entity1643 who have been clinically identified to have @entity717 and determine association of these impairments with @entity158 and fear of movement. STUDY DESIGN/SETTING: The study design includes observational design, university biomechanics laboratory, and clinical practice. @entity1 SAMPLE: Thirty-three @entity1 with acute to subacute @entity1643 presenting with trunk @entity717 and 33 healthy controls matched with gender, age, and body mass index were identified. OUTCOME MEASURES: Self-report measures included Numeric Pain Rating Scale, Oswestry Disability Index Questionnaire, and Fear-Avoidance Beliefs Questionnaire and physiologic measures included postural control and movement precision. METHODS: Center-of-pressure movement was measured while subjects attempted to volitionally control trunk posture and movement while sitting on a platform with a hemisphere mounted underneath. This created an unstable surface that required coordinated trunk control to maintain an upright seated posture. Postural control was tested using eyes-open and -closed balance protocols. Movement precision was tested with a dynamic control test requiring movement of the center of pressure along a discrete path. Group trunk motor control performance was compared with analysis of variance and t test. Performance association with @entity158 and fear of movement were assessed with Pearson correlations. RESULTS: @entity1 ' postural control in the eyes-closed condition (p=.02) and movement precision (p=.04) were significantly impaired compared with healthy controls, with moderate-to-large group difference effect sizes. These trunk motor @entity73 were not significantly associated with the @entity1 self-reported @entity158 characteristics and fear of movement. CONCLUSIONS: @entity1 with clinical identification of trunk @entity717 demonstrated decreased trunk motor control, suggesting that @entity3325 , or central processing occur early in the back @entity158 episode. This information may help to guide interventions to address these specific limitations, improving delivery of care.

title: Trunk motor control deficits in acute and subacute @entity1643 are not associated with XXXX or fear of movement.

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: PURPOSE AND SETTINGS: This study was designed to evaluate the efficacy and safety of @entity1138 ( @entity1139 ) augmented needling procedure in the management of failed bleb after trabeculectomy in @entity10064 . This study was carried out at Ain Shams University Hospital. @entity1 AND METHODS: A retrospective study was carried on 30 eyes of 25 @entity1 with @entity10064 with @entity177 after trabeculectomy. The mean age of the subjects was 7.3    3.4 years (range, 1-12 years). Under general anesthesia, needling procedure was performed with adjunctive use of a mixture of 0.1 mL of @entity1139 (0.04 mg/mL) and 0.2 mL of @entity3303 1% injected subconjunctivally. Needling was performed with a 30-gauge needle to dissect the areas of subconjunctival @entity82 and re-establish aqueous outflow. RESULTS: Follow-up ranged from 6 to 20 months (mean, 9.23    5.25 months). One needling revision was performed in 22 eyes (73.3%) and eight eyes (26.7%) received two needle revisions. The mean intraocular pressure (IOP) decreased from 26.9    2.85 mmHg (range, 21-34 mmHg) before surgery to 15.63    3.15 mmHg (range, 10-24 mmHg) at last follow-up. Complications included significant @entity548 in six eyes, intraoperative @entity4530 in two eyes, @entity1713 in one eye, and minimal @entity735 . CONCLUSION: @entity1139 needle bleb revision appears to be an effective method to revive failed filtration surgery after trabeculectomy in @entity1 with @entity10064 . This technique is effective in reducing IOP with preservation of the remaining conjunctiva for further surgery.

title: XXXX needle bleb revision in @entity10064 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['subconjunctival hemorrhage']

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['choroidal detachment']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin-C']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['bleb failure']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['hyphema in one eye']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

entities_list: @entity10064 :: ('MESH:C565547', 'Disease') :: ['congenital glaucoma']

answer: @entity1138 :: (MESH:D016685,Chemical) :: ['Mitomycin-C']


abstract: PURPOSE AND SETTINGS: This study was designed to evaluate the efficacy and safety of @entity1138 ( @entity1139 ) augmented needling procedure in the management of failed bleb after trabeculectomy in @entity10064 . This study was carried out at Ain Shams University Hospital. @entity1 AND METHODS: A retrospective study was carried on 30 eyes of 25 @entity1 with @entity10064 with @entity177 after trabeculectomy. The mean age of the subjects was 7.3    3.4 years (range, 1-12 years). Under general anesthesia, needling procedure was performed with adjunctive use of a mixture of 0.1 mL of @entity1139 (0.04 mg/mL) and 0.2 mL of @entity3303 1% injected subconjunctivally. Needling was performed with a 30-gauge needle to dissect the areas of subconjunctival @entity82 and re-establish aqueous outflow. RESULTS: Follow-up ranged from 6 to 20 months (mean, 9.23    5.25 months). One needling revision was performed in 22 eyes (73.3%) and eight eyes (26.7%) received two needle revisions. The mean intraocular pressure (IOP) decreased from 26.9    2.85 mmHg (range, 21-34 mmHg) before surgery to 15.63    3.15 mmHg (range, 10-24 mmHg) at last follow-up. Complications included significant @entity548 in six eyes, intraoperative @entity4530 in two eyes, @entity1713 in one eye, and minimal @entity735 . CONCLUSION: @entity1139 needle bleb revision appears to be an effective method to revive failed filtration surgery after trabeculectomy in @entity1 with @entity10064 . This technique is effective in reducing IOP with preservation of the remaining conjunctiva for further surgery.

title: @entity1138 needle bleb revision in XXXX .

answer: @entity10064 :: (MESH:C565547,Disease) :: ['congenital glaucoma']