abstract: BACKGROUND: The 21-gene recurrence score (RS) assay has been validated in retrospective studies as prognostic of distant disease recurrence and predictive of the benefit of adjuvant chemotherapy in @entity172 -receptor-positive @entity0 ( @entity0 ). There is limited published data on the impact of the assay on clinical practice, particularly in the context of a single practice with a unified treatment policy. @entity1 AND METHODS: Between 2006 and 2009, RS was obtained on 135 @entity1 in a single practice with a uniform treatment policy. Treatment recommendations before and after RS result were analyzed retrospectively. Pre-RS treatment recommendations were based on clinicopathological features and Adjuvant! Online (AO) calculated survival advantage. RS and AO survival advantage for adding chemotherapy were compared for each @entity1 . RESULTS: The distribution by risk group of RS was low- 49.6%, intermediate-37.8%, and high-12.6%. In 34 @entity1 (25.2%, 95% confidence interval 17.9% to 32.5%), recommendation for chemotherapy was changed after obtaining assay result. Most changes (70.6%) were from chemotherapy to no chemotherapy. The RS correlated poorly with AO predictions. CONCLUSION: The 21-gene assay, when applied in a consistent manner in early-stage @entity0 , changes treatment recommendations in one-quarter of @entity1 tested.

title: The impact of the 21-gene recurrence score assay on decision making about adjuvant chemotherapy in early-stage @entity172 -receptor-positive XXXX in an oncology practice with a unified treatment policy.

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: Elderly @entity1 have largely been excluded from randomized trials for @entity463 ( @entity463 ). We reviewed the results of treatment approaches, which included surgery, chemotherapy, and radiation in this group of @entity1 . @entity1 were treated during the period 1979-2007 and were 70 years of age and older with histologically confirmed @entity463 . @entity1349 ( @entity1349 ) was the primary endpoint of this retrospective study. Two hundred six @entity1 70 years of age and older were identified. Median age was 75 years (range 70-90). Median @entity1349 time was 4.5 months. Univariate analysis showed that @entity1349 was significantly impacted by KPS score (1.8 months for KPS  <= 50 to 17.2 months for KPS >=  90, P < .001), age at diagnosis (5.1 months for age 70-79 versus 3.1 months for age >=  80, P < .001), and extent of disease (worse for bilateral disease [P = .003], multifocal disease [P = .005], and @entity66 [P = .02]). On multivariate analysis, higher KPS score (P = .006), surgical resection (any surgery beyond biopsy) (P < .001), radiation therapy (P < .001), and chemotherapy (P < .001) were all found to be independently associated with improved @entity1349 . In this study of newly diagnosed @entity463 @entity1 over the age of 70 years, aggressive treatment with radiation, chemotherapy, and surgery is associated with @entity1349 .

title: Aggressive treatment is appropriate for XXXX @entity1 70 years old or older: a retrospective review of 206 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma multiforme', 'GBM', 'glioblastoma']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['multicentric disease']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Overall survival']

answer: @entity463 :: (MESH:D005909,Disease) :: ['glioblastoma multiforme']


abstract: Elderly @entity1 have largely been excluded from randomized trials for @entity463 ( @entity463 ). We reviewed the results of treatment approaches, which included surgery, chemotherapy, and radiation in this group of @entity1 . @entity1 were treated during the period 1979-2007 and were 70 years of age and older with histologically confirmed @entity463 . @entity1349 ( @entity1349 ) was the primary endpoint of this retrospective study. Two hundred six @entity1 70 years of age and older were identified. Median age was 75 years (range 70-90). Median @entity1349 time was 4.5 months. Univariate analysis showed that @entity1349 was significantly impacted by KPS score (1.8 months for KPS  <= 50 to 17.2 months for KPS >=  90, P < .001), age at diagnosis (5.1 months for age 70-79 versus 3.1 months for age >=  80, P < .001), and extent of disease (worse for bilateral disease [P = .003], multifocal disease [P = .005], and @entity66 [P = .02]). On multivariate analysis, higher KPS score (P = .006), surgical resection (any surgery beyond biopsy) (P < .001), radiation therapy (P < .001), and chemotherapy (P < .001) were all found to be independently associated with improved @entity1349 . In this study of newly diagnosed @entity463 @entity1 over the age of 70 years, aggressive treatment with radiation, chemotherapy, and surgery is associated with @entity1349 .

title: Aggressive treatment is appropriate for @entity463 XXXX 70 years old or older: a retrospective review of 206 cases.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: This case report describes a mitral systolic honk originating from the mitral valve and adjacent structures in a 52 year-old @entity1 with @entity4794 . The @entity1 was hospitalized because of @entity1353 . Auscultation of the heart revealed a grade 3/6 apical early systolic honk accompanied by an increased first heart sound, an opening snap and a diastolic rumble. The phonocardiogram demonstrated an early systolic honk at a frequency of 115 Hz. Intensity of the honk varied on beat to beat basis, increasing in the short preceding R-R interval compared to that in the long one. The M-mode echocardiogram showed early systolic fluttering of the mitral valve and chordae tendineae at the same frequency as the honk. The two-dimensional echocardiogram showed bulging of the anterior mitral leaflet toward the left atrium in early systole. After treatment with digitalis and diuretics, the early systolic honk disappeared in beats with preceding long R-R intervals (greater than 1100 msec). In beats without the honk, systolic fluttering of the mitral valve was not observed. The genesis of the early systolic honk is analogous to that of the honk audible in mitral or @entity16742 . The bulging of the anterior mitral leaflet into the left atrium may produce vibrations of the mitral valve leaflets and adjacent structures.

title: [Systolic honk in XXXX : a case report].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity16742 :: ('MESH:D014263', 'Disease') :: ['tricuspid valve prolapse']

entities_list: @entity4794 :: ('MESH:D008946', 'Disease') :: ['mitral stenosis']

answer: @entity4794 :: (MESH:D008946,Disease) :: ['mitral stenosis']


abstract: @entity35869 ( @entity35869 ) is a clinical @entity303 characterized by progressive decline in language function but relative sparing of other cognitive domains. There are three recognized @entity35869 variants: agrammatic, semantic, and logopenic. Although each @entity35869 subtype is characterized by the nature of the principal deficit, individual @entity1 frequently display @entity73 in additional language domains. The present study investigated the distribution of @entity194 related to performance in specific language domains (i.e., grammatical processing, semantic processing, fluency, and sentence repetition) across @entity35869 variants to better understand the anatomical substrates of language. Results showed regionally specific relationships, primarily in the left hemisphere, between @entity194 and impairments in language performance. Most notable was the neuroanatomical distinction between fluency and grammatical processing. Poor fluency was associated with regions dorsal to the traditional boundaries of Broca's area in the inferior frontal sulcus and the posterior middle frontal gyrus, whereas grammatical processing was associated with more widespread @entity194 , including the @entity75 . Repetition performance was correlated with @entity194 in the posterior superior temporal gyrus. The correlation of @entity194 with semantic processing impairment was localized to the anterior temporal poles. Atrophy patterns were more closely correlated with domain-specific performance than with subtype. These results show that @entity35869 reflects a selective disruption of the language network as a whole, with no rigid boundaries between subtypes. Further, these @entity194 patterns reveal anatomical correlates of language that could not have been surmised in @entity1 with @entity2026 resulting from @entity75 .

title: Anatomy of @entity73 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia syndrome']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['subtle impairments']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['inferior frontal gyrus and supramarginal gyrus', 'cerebrovascular lesions']

entities_list: @entity35869 :: ('MESH:D018888', 'Disease') :: ['PPA', 'Primary progressive aphasia']

answer: @entity35869 :: (MESH:D018888,Disease) :: ['primary progressive aphasia']


abstract: @entity35869 ( @entity35869 ) is a clinical @entity303 characterized by progressive decline in language function but relative sparing of other cognitive domains. There are three recognized @entity35869 variants: agrammatic, semantic, and logopenic. Although each @entity35869 subtype is characterized by the nature of the principal deficit, individual @entity1 frequently display @entity73 in additional language domains. The present study investigated the distribution of @entity194 related to performance in specific language domains (i.e., grammatical processing, semantic processing, fluency, and sentence repetition) across @entity35869 variants to better understand the anatomical substrates of language. Results showed regionally specific relationships, primarily in the left hemisphere, between @entity194 and impairments in language performance. Most notable was the neuroanatomical distinction between fluency and grammatical processing. Poor fluency was associated with regions dorsal to the traditional boundaries of Broca's area in the inferior frontal sulcus and the posterior middle frontal gyrus, whereas grammatical processing was associated with more widespread @entity194 , including the @entity75 . Repetition performance was correlated with @entity194 in the posterior superior temporal gyrus. The correlation of @entity194 with semantic processing impairment was localized to the anterior temporal poles. Atrophy patterns were more closely correlated with domain-specific performance than with subtype. These results show that @entity35869 reflects a selective disruption of the language network as a whole, with no rigid boundaries between subtypes. Further, these @entity194 patterns reveal anatomical correlates of language that could not have been surmised in @entity1 with @entity2026 resulting from @entity75 .

title: Anatomy of XXXX in @entity35869 .

answer: @entity73 :: (MESH:D003072,Disease) :: ['language impairments']


abstract: OBJECTIVE: To validate polymerase chain reaction (PCR) analysis for detecting HPV in Mexican @entity1 with @entity3146 , grade 2 and 3 (CIN 2/3) versus histologic evidence. STUDY DESIGN: A diagnostic test study was carried out. A sample of 25 selected @entity1 who were diagnosed by histology as having CIN 2/3 was analyzed. Biopsies were examined for @entity281 using light microscopy. The histologic criteria used for @entity281 included koilocytosis, @entity7063 cells, bi/multinucleation, and @entity8286 . PCR was performed on each sample using commercial probes (MY09 and MY11), and then HPV typing was carried out by restriction fragment length polymorphism analyses. RESULTS: PCR revealed that 88% (22/25) of the @entity1 were HPV positive (19 high risk and 3 low risk). In contrast, histology revealed that 28% (7/25) of the @entity1 were HPV positive. The number of @entity1 infected with HPV was 3.14 times (88/28) more frequently detected with PCR procedure than with the histology. Using PCR as the gold standard, 4 values (true positive, false positive, false negative and true negative) were obtained (7, 0, 15 and 3), and histology had a sensitivity, specificity, and positive and negative predictive values of .32, 1.00, 1.00 and .17, respectively. There was a correlation between low-risk and high-risk for PCR (chi 2 with Yates correction = 6.32, P = .012). CONCLUSION: PCR is a powerful tool for the early detection of @entity281 and is independent of histologic criteria.

title: Validating polymerase chain reaction for detecting HPV in XXXX .

entities_list: @entity7063 :: ('MESH:D019871', 'Disease') :: ['dyskeratosis']

entities_list: @entity8286 :: ('MESH:D010241', 'Disease') :: ['parakeratosis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['HPV infection']

entities_list: @entity3146 :: ('MESH:D018290', 'Disease') :: ['cervical intraepithelial neoplasia']

answer: @entity3146 :: (MESH:D018290,Disease) :: ['cervical intraepithelial neoplasia']


abstract: BACKGROUND: Endothelial progenitor cells (EPCs) have been implicated in neoangiogenesis, endothelial repair and cell-based therapies for @entity65 . We have previously shown that the recruitment of EPCs to sites of @entity455 is facilitated by platelets where EPCs, in turn, modulate platelet function and @entity715 . However, EPCs encompass a heterogeneous population of progenitor cells that may exert different effects on platelet function. Recent evidence suggests the existence of two EPC subtypes: early outgrowth cells (EOCs) and endothelial colony-forming cells (ECFCs). We aimed at characterizing these two EPC subtypes and at identifying their role in @entity1423 . METHODS: EOCs and ECFCs were generated from @entity1 peripheral blood mononuclear cells (PBMCs) seeded in conditioned media on fibronectin and collagen, respectively. The morphological, phenotypical and functional characteristics of EOCs and ECFCs were assessed by optical and confocal laser scanning microscopes, cell surface markers expression, and Matrigel tube formation. The impact of EOCs and ECFCs on @entity1423 was monitored in collagen-induced optical aggregometry and compared with PBMCs and @entity1 umbilical vein endothelial cells (HUVECs). The levels of the anti-platelet agents' @entity842 (NO) and @entity4770 ( @entity4770 ) released from cultured cells as well as the expression of their respective producing enzymes NO synthases (NOS) and cyclooxygenases (COX) were also assessed. RESULTS: We showed that EOCs display a monocytic-like phenotype whereas ECFCs have an endothelial-like phenotype. We demonstrated that both EOCs and ECFCs and their supernatants inhibited @entity1423 ; however ECFCs were more efficient than EOCs. This could be related to the release of significantly higher amounts of NO and @entity4770 from ECFCs, in comparison to EOCs. Indeed, ECFCs, like HUVECs, constitutively express the endothelial (eNOS)-and inducible (iNOS)-NOS isoforms, and @entity9859 and weakly express @entity2247 , whereas EOCs do not constitutively express these NO and @entity4770 producing enzymes. CONCLUSION: The different morphological, phenotypic and more importantly the release of the anti-aggregating agents @entity4770 and NO in each EPC subtype are implicated in their respective roles in platelet function and thus, may be linked to the increased efficiency of ECFCs in inhibiting @entity1423 as compared to EOCs.

title: Early outgrowth cells versus endothelial colony forming cells functions in XXXX .

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular lesions']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity4770 :: ('MESH:D011464', 'Chemical') :: ['PGI2', 'prostacyclin']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity1423 :: (MESH:D001791,Disease) :: ['platelet aggregation']


abstract: UNASSIGNED: Proteomics studies typically analyze proteins at a population level, using extracts prepared from tens of thousands to millions of cells. The resulting measurements correspond to average values across the cell population and can mask considerable variation in protein expression and function between individual cells or organisms. Here, we report the development of micro-proteomics for the analysis of @entity2199 , a eukaryote composed of 959 somatic cells and    1,500 germ cells, measuring the worm proteome at a single organism level to a depth of     3,000 proteins. This includes detection of proteins across a wide dynamic range of expression levels (> 6 orders of magnitude), including many chromatin-associated factors involved in chromosome structure and gene regulation. We apply the micro-proteomics workflow to measure the global proteome response to @entity1457 in individual @entity2199 . This shows variation between individual animals in the magnitude of proteome response following @entity1457 , including variable induction of @entity1457 . The micro-proteomics pipeline thus facilitates the investigation of stochastic variation in protein expression between individuals within an isogenic population of @entity2199 . All data described in this study are available online via the Encyclopedia of Proteome Dynamics (http://www.peptracker.com/epd), an open access, searchable database resource. This article is protected by copyright. All rights reserved.

title: Micro-proteomics with iterative data analysis: proteome analysis in XXXX at the single worm level.

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['heat-shock proteins', 'heat-shock']

entities_list: @entity2199 :: ('6239', 'Species') :: ['nematodes', 'C. elegans']

answer: @entity2199 :: (6239,Species) :: ['C. elegans']


abstract: PURPOSE: This study explored a causal model explaining @entity2 @entity1 currently undertaking Chemotherapy. METHOD: In this cross-sectional study, a convenience sample of 246 @entity2 @entity1 were recruited from six Oncology centers throughout the north of Vietnam. The hypothesized model, consisting of @entity22 , @entity1353 , cough, @entity148 , stage of disease, physical activity, nutritional status, and number of completed chemotherapy cycles, was constructed based on Piper's Integrated Fatigue Model and a review of the literature. RESULTS: All factors, except the number of completed chemotherapy cycles significantly affected @entity1295 . The hypothesized model explained 42.9% of @entity1295 variance. @entity1353 had the largest total effect on @entity1295 (b  =  0.397, p  <  0.01), followed by cough (b  =  0.343, p  <  0.01), @entity22 (b  =  0.318 (p  <  0.01), and @entity148 (b  =  0.115, p  <  0.05). However, @entity22 had the greatest direct effect on @entity1295 . There was also interplay among those four factors in determining @entity1295 . Physical activity and nutrition status had small effects on @entity1295 (b  =  - 0.148, p  <  0.01 and b  =  - 0.156, p  <  0.01). CONCLUSION: The model fits well to explain @entity1295 . Having the largest direct effect on @entity1295 , @entity22 appeared as a factor of choice for future @entity1295 control programs. Due to its higher direct effect on @entity1295 , @entity1353 was recommended over cough for @entity1295 management. Additionally, the interactions among @entity1295 , @entity1353 , and cough suggested that comprehensive programs, which simultaneously address these three symptoms, would be a promising approach for practitioners to consider.

title: A causal model for XXXX @entity1 receiving chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['Dyspnea', 'dyspnea']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer', 'fatigue in lung cancer']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']

answer: @entity2 :: (MESH:D008175,Disease) :: ['fatigue in lung cancer']


abstract: PURPOSE: This study explored a causal model explaining @entity2 @entity1 currently undertaking Chemotherapy. METHOD: In this cross-sectional study, a convenience sample of 246 @entity2 @entity1 were recruited from six Oncology centers throughout the north of Vietnam. The hypothesized model, consisting of @entity22 , @entity1353 , cough, @entity148 , stage of disease, physical activity, nutritional status, and number of completed chemotherapy cycles, was constructed based on Piper's Integrated Fatigue Model and a review of the literature. RESULTS: All factors, except the number of completed chemotherapy cycles significantly affected @entity1295 . The hypothesized model explained 42.9% of @entity1295 variance. @entity1353 had the largest total effect on @entity1295 (b  =  0.397, p  <  0.01), followed by cough (b  =  0.343, p  <  0.01), @entity22 (b  =  0.318 (p  <  0.01), and @entity148 (b  =  0.115, p  <  0.05). However, @entity22 had the greatest direct effect on @entity1295 . There was also interplay among those four factors in determining @entity1295 . Physical activity and nutrition status had small effects on @entity1295 (b  =  - 0.148, p  <  0.01 and b  =  - 0.156, p  <  0.01). CONCLUSION: The model fits well to explain @entity1295 . Having the largest direct effect on @entity1295 , @entity22 appeared as a factor of choice for future @entity1295 control programs. Due to its higher direct effect on @entity1295 , @entity1353 was recommended over cough for @entity1295 management. Additionally, the interactions among @entity1295 , @entity1353 , and cough suggested that comprehensive programs, which simultaneously address these three symptoms, would be a promising approach for practitioners to consider.

title: A causal model for @entity2 XXXX receiving chemotherapy.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: We have studied the formation of experimental B16 @entity320 metastases in the lungs of @entity19 inoculated IV with tumoricidal or nontumoricidal peritoneal macrophages elicited by various agents. IV inoculation of peritoneal M phi elicited by Brewer's thioglycollate medium (TG-M phi) 1 day before the injection of B16 @entity320 cells dramatically increased the number of metastatic foci in the lungs. NIH thioglycollate broth and proteose peptone each elicited a relatively low number of M phi, which were morphologically distinguishable from TG-M phi and did not influence the yield of B16 @entity320 colonies in the lungs. Resident or C. pravum-elicited M phi also did not augment @entity3 formation. TG-M phi became highly tumoricidal after IP stimulation with poly I:C. However, tumoricidal TG-M phi inoculated IV 1 day before IV inoculation of B16 @entity320 cells did not have an antimetastatic effect. On the contrary, both tumoricidal and nontumoricidal TG-M phi augmented @entity3 formation. Poly I:C treatment had a substantial antimetastatic effect in the normal @entity19 , but not in @entity19 with adoptively transferred TG-M phi. Histological analysis revealed that IV-inoculated TG-M phi (tumoricidal or nontumoricidal, either viable or disrupted) induced severe intravascular reaction in the lungs, but not in the liver or kidney. This reaction manifested in the aggregation of the various blood cells, preferentially neutrophils. These reactions were not observed after IV inoculation of PM phi or NIH TG-M phi. Intravascular inflammatory reactions induced by TG-M phi may be responsible for the augmentation of @entity3 formation, partly by suppression of NK reactivity and mostly by the acceleration of the processes of @entity5 cell extravasation. These data may provide some insight into the failure to achieve systemic adoptive immunotherapy using activated peritoneal TG-M phi.

title: Modulation of formation of XXXX metastases by peritoneal macrophages elicited by various agents.

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: BACKGROUND: The QT interval measures cardiac repolarization, and prolongation is associated with adverse cardiovascular outcomes and @entity204 . The exponential Bazett correction formula overestimates the QT interval during @entity591 . OBJECTIVE: We evaluated 4 formulas of @entity1162 in individuals with @entity7129 for the identification of @entity453 , @entity712 , and mortality. METHODS: The Penn @entity955 Free study is a large cohort study of @entity1 without @entity955 . The present study examined 6723 Penn @entity955 Free study @entity1 without a history of @entity712 and with baseline @entity50 rate >= 100 beats/min. Medical records were queried for index clinical parameters, incident cardiovascular events, and all-cause mortality. The QT interval was corrected by using Bazett (QT/RR(0.5)), Fridericia (QT/RR(0.33)), Framingham [QT + 0.154 * (1000 - RR)], and Hodges (QT + 105 * (1/ @entity4736 )) formulas. RESULTS: In 6723 @entity1 with a median follow-up of 4.5 years (interquartile range 1.9-6.4 years), the annualized cardiovascular event rate was 2.3% and the annualized mortality rate was 2.2%. QT prolongation was diagnosed in 39% of the cohort using the Bazett formula, 6.2% using the Fridericia formula, 3.7% using the Framingham formula, and 8.7% using the Hodges formula. Only the Hodges formula was an independent risk marker for @entity204 across the range of QT values (highest tertile: hazard ratio 1.26; 95% confidence interval 1.03-1.55). CONCLUSION: Although all correction formulas demonstrated an association between QTc values and cardiovascular events, only the Hodges formula identified one-third of individuals with @entity591 that are at higher risk of all-cause mortality. Furthermore, the Bazett correction formula overestimates the number of @entity1 with a prolonged QT interval and was not associated with mortality. Future work may validate these findings and result in changes to automated algorithms for QT interval assessment.

title: Optimal @entity1162 formula in XXXX for identifying cardiovascular and mortality risk: Findings from the Penn @entity955 Free study.

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'Atrial Fibrillation']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['QT correction']

entities_list: @entity7129 :: ('MESH:D013616', 'Disease') :: ['sinus tachycardia']

answer: @entity7129 :: (MESH:D013616,Disease) :: ['sinus tachycardia']


abstract: BACKGROUND: The QT interval measures cardiac repolarization, and prolongation is associated with adverse cardiovascular outcomes and @entity204 . The exponential Bazett correction formula overestimates the QT interval during @entity591 . OBJECTIVE: We evaluated 4 formulas of @entity1162 in individuals with @entity7129 for the identification of @entity453 , @entity712 , and mortality. METHODS: The Penn @entity955 Free study is a large cohort study of @entity1 without @entity955 . The present study examined 6723 Penn @entity955 Free study @entity1 without a history of @entity712 and with baseline @entity50 rate >= 100 beats/min. Medical records were queried for index clinical parameters, incident cardiovascular events, and all-cause mortality. The QT interval was corrected by using Bazett (QT/RR(0.5)), Fridericia (QT/RR(0.33)), Framingham [QT + 0.154 * (1000 - RR)], and Hodges (QT + 105 * (1/ @entity4736 )) formulas. RESULTS: In 6723 @entity1 with a median follow-up of 4.5 years (interquartile range 1.9-6.4 years), the annualized cardiovascular event rate was 2.3% and the annualized mortality rate was 2.2%. QT prolongation was diagnosed in 39% of the cohort using the Bazett formula, 6.2% using the Fridericia formula, 3.7% using the Framingham formula, and 8.7% using the Hodges formula. Only the Hodges formula was an independent risk marker for @entity204 across the range of QT values (highest tertile: hazard ratio 1.26; 95% confidence interval 1.03-1.55). CONCLUSION: Although all correction formulas demonstrated an association between QTc values and cardiovascular events, only the Hodges formula identified one-third of individuals with @entity591 that are at higher risk of all-cause mortality. Furthermore, the Bazett correction formula overestimates the number of @entity1 with a prolonged QT interval and was not associated with mortality. Future work may validate these findings and result in changes to automated algorithms for QT interval assessment.

title: Optimal @entity1162 formula in @entity7129 for identifying cardiovascular and mortality risk: Findings from the Penn XXXX Free study.

answer: @entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']


abstract: BACKGROUND: The QT interval measures cardiac repolarization, and prolongation is associated with adverse cardiovascular outcomes and @entity204 . The exponential Bazett correction formula overestimates the QT interval during @entity591 . OBJECTIVE: We evaluated 4 formulas of @entity1162 in individuals with @entity7129 for the identification of @entity453 , @entity712 , and mortality. METHODS: The Penn @entity955 Free study is a large cohort study of @entity1 without @entity955 . The present study examined 6723 Penn @entity955 Free study @entity1 without a history of @entity712 and with baseline @entity50 rate >= 100 beats/min. Medical records were queried for index clinical parameters, incident cardiovascular events, and all-cause mortality. The QT interval was corrected by using Bazett (QT/RR(0.5)), Fridericia (QT/RR(0.33)), Framingham [QT + 0.154 * (1000 - RR)], and Hodges (QT + 105 * (1/ @entity4736 )) formulas. RESULTS: In 6723 @entity1 with a median follow-up of 4.5 years (interquartile range 1.9-6.4 years), the annualized cardiovascular event rate was 2.3% and the annualized mortality rate was 2.2%. QT prolongation was diagnosed in 39% of the cohort using the Bazett formula, 6.2% using the Fridericia formula, 3.7% using the Framingham formula, and 8.7% using the Hodges formula. Only the Hodges formula was an independent risk marker for @entity204 across the range of QT values (highest tertile: hazard ratio 1.26; 95% confidence interval 1.03-1.55). CONCLUSION: Although all correction formulas demonstrated an association between QTc values and cardiovascular events, only the Hodges formula identified one-third of individuals with @entity591 that are at higher risk of all-cause mortality. Furthermore, the Bazett correction formula overestimates the number of @entity1 with a prolonged QT interval and was not associated with mortality. Future work may validate these findings and result in changes to automated algorithms for QT interval assessment.

title: Optimal XXXX formula in @entity7129 for identifying cardiovascular and mortality risk: Findings from the Penn @entity955 Free study.

answer: @entity1162 :: (MESH:D008133,Disease) :: ['QT correction']


abstract: PURPOSE: @entity6520 ( @entity6520 ) may likely influence recanalization after thrombolysis. We assessed, through the European sequential MRI database "I-KNOW," the relationship between the presence of @entity6520 on T2-weighted gradient echo imaging, its angiographic counterpart on magnetic resonance angiography and its subsequent impact on recanalization after thrombolysis. MATERIALS AND METHODS: Initial clinical and MRI characteristics and early follow up were analyzed in acute @entity63 @entity64 @entity1 treated with rt-Pa within 4.5 hours. @entity1 underwent multimodal MRI at admission. Sequential imaging performed 3 hours, 2 days and 1 month later allowed the analysis of @entity6520 changes and recanalization. RESULTS: Fifty @entity1 were included in the study. @entity6520 was observed in 54% of cases at admission. @entity6520 was still present in 46% @entity1 at 3 hours, 16% at 2 days, and 0% at 1 month. It was an independent predictor of no recanalization after thrombolysis (P = .04). After 3 hours, @entity6520 disappeared in only 4 cases, and was not linked with recanalization on MRA. Conversely, when @entity6520 persisted, a partial or complete recanalization was observed in 9 and 6 cases, respectively. CONCLUSIONS: @entity6520 is a predictor of lower recanalization rate. Its disappearance is not necessarily correlated with recanalization.

title: Sequential MR Assessment of the Susceptibility Vessel Sign and Arterial Occlusion in Acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6520 :: ('MESH:C536223', 'Disease') :: ['Susceptibility vessel sign', 'SVS']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: PURPOSE: Enhanced S Cone Syndrome is a rare @entity74 characterized clinically by an absence of rod function, a replacement of most L and M cone function by S cone activity ( @entity14782 ) and by variable degrees of @entity2000 in different families. The causative gene, @entity32915 ( @entity32915 ), controls the developmental sequence for rods and cones. The purpose of this study was to compare the nature and implications of mutations in two subjects with Enhanced S Cone Syndrome who have significantly different degrees of @entity179 . METHODS: A direct sequencing approach was used to identify the mutations. Genomic DNA was amplified from all the exons of @entity32915 and used as a template for sequencing. Of the two families studied, Case 1 is of Persian ethnicity while Case 2 is Brazilian. A total of six individuals within the two families were studied. RESULTS: Case 1 (original propositus of the syndrome) has the characteristic developmental rod/cone abnormality with large amplitude electroretinogram responses and no @entity2000 . She was homozygous for a novel mutation, @entity72527 ( @entity72528 ), which lies entirely within the P-box for this gene. By comparison, Case 2 had @entity14782 with @entity2000 and low electroretinogram signals. She was a compound heterozygote for @entity72529 ( @entity72530 ), mutations that have been reported previously. Her second mutation overlaps that of Case 1 within the P-box. CONCLUSIONS: The novel in-frame homozygous deletion of Case 1, within the P-box motif of the DNA binding domain, caused a @entity851 without @entity2000 . Case 2, with more traditional @entity14782 with @entity2000 , was a compound heterozygote where one allele had a similar P-box deletion but the other was a splicing defect. Case 1 is the first reported homozygous deletion within the P-box. This is the first report of @entity32915 mutations in a Persian and a Brazilian family.

title: Developmental or degenerative-- XXXX gene mutations in two patients with enhanced S cone syndrome.

entities_list: @entity2000 :: ('MESH:D012162', 'Disease') :: ['retinal degeneration']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['developmental abnormality']

entities_list: @entity14782 :: ('MESH:C564835', 'Disease') :: ['Goldmann-Favre Syndrome']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative damage']

entities_list: @entity32915 :: ('10002', 'Gene') :: ['NR2E3', 'nuclear receptor subfamily 2, group E, member 3']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal recessive disorder']

answer: @entity32915 :: (10002,Gene) :: ['NR2E3']


abstract: BACKGROUND: Nowadays, the collection of PBPCs by apheresis from healthy donors is a routine method. The mobilization with rHu @entity1261 and the apheresis procedures are usually well tolerated without severe side effects. STUDY DESIGN AND METHODS: We report a severe complication in a 41-year-old unrelated female donor who was allowed to donate PBPCs and was mobilized with 10 microg of @entity1261 per kg per day. During PBPC apheresis, she experienced a @entity1167 after 132 minutes and processing of 7078 mL of blood (twice the donor's blood volume). RESULTS: Immediate cardiopulmonary resuscitation restored sinus rhythm and regulatory respiration without sequelae. Subsequent cardiologic examinations (heart catheterization, electrophysiologic testing, tilting table test) resulted in the diagnosis of a @entity907 . Other @entity299 could be excluded. The implantation of a cardiac pacemaker was recommended to the donor. The 4-year-old recipient was successfully transplanted with the partial product collected until the arrest occurred. The @entity1 received a total of 2.54 x 106 @entity2280 + cells per kg of body weight. CONCLUSION: After exclusion of other @entity299 , the diagnosed @entity907 probably induced the @entity1167 during apheresis rather than the administration of @entity1261 .

title: XXXX during PBPC apheresis in an unrelated donor.

entities_list: @entity907 :: ('MESH:D019462', 'Disease') :: ['neurocardiogenic syncope']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac diseases', 'cardiac or circulatory disorders']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['circulatory arrest']

answer: @entity1167 :: (MESH:D006323,Disease) :: ['Circulatory arrest']


abstract: PURPOSE: Treatment of the posterior @entity3202 mandible has long been a challenge in implant dentistry and maxillofacial surgery. The objective of this study was to reevaluate the safety and efficacy of the sandwich osteotomy and bone grafting in @entity1 with moderate to severe posterior mandibular @entity194 . MATERIALS AND METHODS: This retrospective study included @entity1 with an edentulous posterior mandible in which there was not enough bone above the dental nerve to insert implants at least 10 mm in length; @entity1 with adequate bone volume but with an excessive interocclusal distance at the posterior occlusal region were also included. Twenty-three @entity1 with 30 sites of moderate to severe posterior @entity194 were treated using a sandwich osteotomy above the mental nerve and an interpositioned block of autologous or allogeneic bone. Success criteria were based on the possibility of implant insertion after bone grafting. RESULTS: The average gain in height was 5.3 mm (range, 2 to 10 mm). Partial @entity604 was observed in only one @entity1 from the allogeneic graft group. @entity1 were followed for 12 to 93 months after bone grafting. No signs of @entity281 were observed. Minor dehiscence of the surgical wound occurred in four segments, but healing ultimately occurred in every @entity1 . Sixty-five implants were placed, and none were lost during follow-up. Insertion of implants of 10 mm or more in length was successfully achieved in 90.8% of the sites, and partial success (ie, bone segments suitable for insertion of shorter implants) was seen in the remaining sites. CONCLUSIONS: Moderate to severe posterior mandibular @entity194 can be successfully treated by interpositional sandwich osteotomy and bone grafting, allowing for the subsequent placement of implants and fixed prostheses in all segments.

title: Implant rehabilitation of the edentulous posterior XXXX mandible: the sandwich osteotomy revisited.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['loss of alveolar height']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity3202 :: (MESH:D016109,Disease) :: ['atrophic']


abstract: OBJECTIVE: To study @entity102 ( @entity102 ) with concurrent @entity697 ( @entity697 ) in regions of high altitude. METHODS: 18,090 inpatients from Feb. 1956 to Dec. 1995 conforming to a screening standard were observed in a hospital located at altitude 3658 m. 1,028 inpatients suffering from @entity102 when hospitalized were collected as a study group. 17,020 inpatients suffering from non-HAD when first hospitalized served as a control group. The morbidity rate of @entity697 in these two groups in a follow-up period of 1 - 20 years was analyzed. RESULTS: (1) @entity697 morbidity rate was increasing with prolongation of observation time in the control group, but it was not so in the study group. Annual and accumulative morbidity of @entity697 in the study group was obviously higher than that in the control group (P < 0.005, OR = 5.03, RR = 4.33). (2) The morbidity rates of three types of @entity697 aside from @entity3126 ( @entity3126 ) of @entity101 ( @entity101 ) group and @entity2657 ( @entity2657 ) of @entity299 ( @entity299 ) group was obviously higher in the study group than in the control (P < 0.05 - 0.005). @entity697 morbidity rate in @entity299 group and @entity195 was 23.5% and 22.0% (OR = 7.33 - 6.71, RR = 5.86 - 5.47). (3) @entity697 morbidity rate in @entity299 group and @entity195 group was obviously higher than that in the control, constituting mainly a high morbidity of mild @entity697 . CONCLUSION: The risk of @entity697 increases about 5-fold in @entity102 @entity1 than in the multitude of high altitude acclimatization, being most evident in @entity299 and @entity195 .

title: [A retrospective clinical study of XXXX complicated by acute exacerbation in high altitude environment].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['AHAD', 'acute high altitude disease']

entities_list: @entity2657 :: ('MESH:D001929', 'Disease') :: ['HACE', 'high altitude cerebral edema']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['high altitude hypertension', 'HAH']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['high altitude pulmonary edema', 'HAPE']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic high altitude disease', 'CHAD']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Monge's disease"]

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['HAHD', 'high altitude heart disease']

answer: @entity102 :: (MESH:D002908,Disease) :: ['chronic high altitude disease']


abstract: @entity131 ( @entity131 ) @entity194 and @entity194 rates are putative clinical markers of progression to @entity195 ( @entity195 ). We compared results given by two different automated @entity131 segmentation techniques in the @entity195 Neuroimaging Initiative dataset between two time intervals. We used @entity131 volumetric automated segmentation data for a total of 683 @entity1 at baseline (198 controls, 331 with @entity73 ( @entity73 ) and 154 with @entity195 ), 684 at 6 months (198 controls, 332 with @entity73 and 154 with @entity195 ) and 587 at 12 months (176 controls, 280 with @entity73 and 131 with @entity195 ). Segmentation techniques included FreeSurfer and @entity26946 . We calculated @entity131 monthly @entity194 rates between baseline and 6 months and between 6 and 12 months, and used a multiple-way ANOVA for repeated measures. Mean @entity131 volumes decrease with time. The only significant (p<0.05) main effect was diagnosis. We measured strong interaction between technique and scan interval and weak interaction between diagnoses and scan interval. When compared to mean rates from largely manual segmentation, automated segmentation results show increased @entity194 rates for both @entity26946 and FreeSurfer techniques. While sensitive, there remains substantial technique variability, likely due to differences in methodological approaches and especially @entity131 . These fundamental metrological problems need to be resolved before concluding with certainty on the accuracy and reliability of automated techniques.

title: XXXX rates in @entity195 : automated segmentation variability analysis.

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['HC', 'Hippocampal', 'neuroanatomical HC definitions']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['MCI', 'mild cognitive impairment']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", "Alzheimer's Disease"]

answer: @entity194 :: (MESH:D001284,Disease) :: ['Hippocampal atrophy']


abstract: @entity131 ( @entity131 ) @entity194 and @entity194 rates are putative clinical markers of progression to @entity195 ( @entity195 ). We compared results given by two different automated @entity131 segmentation techniques in the @entity195 Neuroimaging Initiative dataset between two time intervals. We used @entity131 volumetric automated segmentation data for a total of 683 @entity1 at baseline (198 controls, 331 with @entity73 ( @entity73 ) and 154 with @entity195 ), 684 at 6 months (198 controls, 332 with @entity73 and 154 with @entity195 ) and 587 at 12 months (176 controls, 280 with @entity73 and 131 with @entity195 ). Segmentation techniques included FreeSurfer and @entity26946 . We calculated @entity131 monthly @entity194 rates between baseline and 6 months and between 6 and 12 months, and used a multiple-way ANOVA for repeated measures. Mean @entity131 volumes decrease with time. The only significant (p<0.05) main effect was diagnosis. We measured strong interaction between technique and scan interval and weak interaction between diagnoses and scan interval. When compared to mean rates from largely manual segmentation, automated segmentation results show increased @entity194 rates for both @entity26946 and FreeSurfer techniques. While sensitive, there remains substantial technique variability, likely due to differences in methodological approaches and especially @entity131 . These fundamental metrological problems need to be resolved before concluding with certainty on the accuracy and reliability of automated techniques.

title: @entity194 rates in XXXX : automated segmentation variability analysis.

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']


abstract: This essay contrasts the responses of @entity1 with @entity64 described by Kaufman with the reflections of @entity1 with @entity1566 ( @entity1566 ). It is suggested that, over the last decade or so, mainstream medicine has become less reductionist and more humane in focus. Many with @entity1566 become reconciled to their new bodies, though this may take years. It is not clear whether this apparent difference in the responses of those with @entity64 , related by Kaufman, reflects their older age or other factors. Perhaps it takes longer than 2 to 3 years for some @entity1 to become reconciled to profound alterations in their embodiment. Medical and social models of impairment are discussed. The effects of personal reductions in function may be lessened in significance through appropriate environmental adaptations and changes in social attitudes. In agreement with Kaufman, the importance of an effective personal assistant/employer relationship is illustrated in relation to those with @entity1688 . Overall the perspective of @entity1 with @entity1566 is not as pessimistic as that of those with @entity64 , as related by Kaufman. However, her plea for a deeper and richer exploration of the lived experience of @entity73 is supported for many reasons.

title: Pathways to the reconstruction of selfhood in chronic transformative disability: the example of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['people', 'persons']

entities_list: @entity1688 :: ('MESH:D011782', 'Disease') :: ['quadriplegia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['chronic impairment']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: BACKGROUND: This study examined the relationship between emotional distress as measured by the @entity308 ( @entity308 ) and the Fertility Quality of Life (FertiQoL) questionnaire. METHODS: The FertiQoL and @entity308 were distributed to a random sample of 785 @entity1 attending 29 Dutch clinics for medically assisted reproduction. FertiQoL was psychometrically tested for reliability. Pearson's correlations were calculated between subscales of FertiQoL and @entity308 . Using an independent t-test, differences between @entity1 subgroups were computed for both instruments. The threshold for clinically meaningful @entity308 / @entity148 on the @entity308 subscales was used to ascertain the critical threshold for high distress on the FertiQoL scales. RESULTS: FertiQoL and @entity308 were completed by 583 @entity1 (response 74%). Reliability of FertiQoL scales was high (reliability coefficient between 0.72 and 0.91). Significant negative correlations were found between FertiQoL subscales and @entity308 scores for @entity148 and @entity308 , ranging from -0.29 to -0.71. Means on FertiQoL scales and @entity308 scales of couples undergoing an assisted reproductive technology (ART) treatment and a non-ART treatment did not differ significantly. @entity1 scoring above the @entity308 threshold for pathology on @entity148 had an average FertiQoL score of 58.8, whereas @entity1 exceeding the @entity308 @entity308 threshold had a FertiQoL total score of 51.9 (range 0-100). CONCLUSIONS: Our study confirms the expected negative relation between quality of life as measured by FertiQoL and @entity148 and @entity308 . The data support that FertiQoL reliably measures QoL in @entity1 facing @entity249 . FertiQoL enables clinicians to tailor care more specifically to the @entity1 in a comprehensive way.

title: Relationship between quality of life and distress in XXXX : a validation study of the Dutch FertiQoL.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['HADS', 'Hospital Anxiety and Depression Scale', 'depression']

answer: @entity249 :: (MESH:D007246,Disease) :: ['infertility']


abstract: OBJECTIVES: Head-to-head comparison of ultrasound and CT accuracy in common diagnoses causing acute @entity490 . MATERIALS AND METHODS: Consecutive @entity1 with @entity490 for >2 h and <5 days referred for imaging underwent both US and CT by different radiologists/radiological residents. An expert panel assigned a final diagnosis. Ultrasound and CT sensitivity and predictive values were calculated for frequent final diagnoses. Effect of @entity1 characteristics and observer experience on ultrasound sensitivity was studied. RESULTS: Frequent final diagnoses in the 1,021 @entity1 (mean age 47; 55% female) were @entity698 (284; 28%), @entity4436 (118; 12%) and @entity2679 (52; 5%). The sensitivity of CT in detecting @entity698 and @entity4436 was significantly higher than that of ultrasound: 94% versus 76% (p   <   0.01) and 81% versus 61% (p   =   0.048), respectively. For @entity2679 , the sensitivity of both was 73% (p   =   1.00). Positive predictive values did not differ significantly between ultrasound and CT for these conditions. Ultrasound sensitivity in detecting @entity698 and @entity4436 was not significantly negatively affected by @entity1 characteristics or reader experience. CONCLUSION: CT misses fewer cases than ultrasound, but both ultrasound and CT can reliably detect common diagnoses causing acute @entity490 . Ultrasound sensitivity was largely not influenced by @entity1 characteristics and reader experience.

title: A comparison of the accuracy of ultrasound and computed tomography in common diagnoses causing acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity698 :: ('MESH:D001064', 'Disease') :: ['appendicitis']

entities_list: @entity2679 :: ('MESH:D002764', 'Disease') :: ['cholecystitis']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity4436 :: ('MESH:D004238', 'Disease') :: ['diverticulitis']

answer: @entity490 :: (MESH:D015746,Disease) :: ['abdominal pain']


abstract: @entity3088 have been proposed to act as chemopreventive agents in numerous epidemiological studies and have been shown to inhibit angiogenesis and proliferation of @entity5 cells and endothelial cells in vitro. Angiogenesis requires tightly controlled extracellular matrix degradation mediated by extracellular proteolytic enzymes including matrix metalloproteinases (MMPs) and @entity563 proteases, in particular, the urokinase-type plasminogen activator ( @entity2290 )-plasmin system. In this study, we have investigated the antiangiogenic mechanism of the @entity3088 , @entity670 , @entity15476 , and @entity21538 in a @entity1 umbilical vein endothelial cell (HUVEC) model. The stimulation of serum-starved HUVECs with vascular endothelial growth factor/basic fibroblast growth factor ( @entity23625 ) caused marked increase in @entity3334 production and induced the pro- @entity1476 activation accompanied by the increase in @entity1551 expression. However, pretreatment with @entity3088 before @entity7 / @entity540 stimulation completely abolished the @entity7 / @entity540 -stimulated increase in @entity3334 and @entity1551 expression and pro- @entity1476 activation. @entity670 blocked @entity7 / @entity540 -stimulated increase in @entity2843 expression and decrease in @entity1552 expression. @entity15476 and @entity21538 further decreased @entity2843 expression below basal level and completely abolished @entity1552 expression. @entity7 and @entity540 stimulation also significantly induced @entity2290 expression, most strikingly the level of 33 kDa @entity2290 , and increased the expression of @entity2289 . @entity670 , @entity15476 , and @entity21538 effectively blocked the generation of 33 kDa @entity2290 , and further decreased the activity of the 55 kDa @entity2290 and the expression of @entity2289 below the basal level. In conclusion, these data suggest that @entity670 , @entity15476 , and @entity21538 inhibit in vitro angiogenesis, in part via preventing @entity7 / @entity540 -induced @entity3334 and @entity2290 expression and the activation of pro- @entity1476 , and via modulating their inhibitors, @entity16617 , and @entity2289 .

title: @entity3088 inhibit XXXX / @entity540 -induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.

entities_list: @entity670 :: ('MESH:D019833', 'Chemical') :: ['Genistein', 'genistein']

entities_list: @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids', 'Flavonoids']

entities_list: @entity15476 :: ('MESH:D047310', 'Chemical') :: ['Apigenin', 'apigenin']

entities_list: @entity21538 :: ('MESH:C041477', 'Chemical') :: ['3-hydroxyflavone']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

answer: @entity7 :: (7422,Gene) :: ['VEGF']


abstract: @entity3088 have been proposed to act as chemopreventive agents in numerous epidemiological studies and have been shown to inhibit angiogenesis and proliferation of @entity5 cells and endothelial cells in vitro. Angiogenesis requires tightly controlled extracellular matrix degradation mediated by extracellular proteolytic enzymes including matrix metalloproteinases (MMPs) and @entity563 proteases, in particular, the urokinase-type plasminogen activator ( @entity2290 )-plasmin system. In this study, we have investigated the antiangiogenic mechanism of the @entity3088 , @entity670 , @entity15476 , and @entity21538 in a @entity1 umbilical vein endothelial cell (HUVEC) model. The stimulation of serum-starved HUVECs with vascular endothelial growth factor/basic fibroblast growth factor ( @entity23625 ) caused marked increase in @entity3334 production and induced the pro- @entity1476 activation accompanied by the increase in @entity1551 expression. However, pretreatment with @entity3088 before @entity7 / @entity540 stimulation completely abolished the @entity7 / @entity540 -stimulated increase in @entity3334 and @entity1551 expression and pro- @entity1476 activation. @entity670 blocked @entity7 / @entity540 -stimulated increase in @entity2843 expression and decrease in @entity1552 expression. @entity15476 and @entity21538 further decreased @entity2843 expression below basal level and completely abolished @entity1552 expression. @entity7 and @entity540 stimulation also significantly induced @entity2290 expression, most strikingly the level of 33 kDa @entity2290 , and increased the expression of @entity2289 . @entity670 , @entity15476 , and @entity21538 effectively blocked the generation of 33 kDa @entity2290 , and further decreased the activity of the 55 kDa @entity2290 and the expression of @entity2289 below the basal level. In conclusion, these data suggest that @entity670 , @entity15476 , and @entity21538 inhibit in vitro angiogenesis, in part via preventing @entity7 / @entity540 -induced @entity3334 and @entity2290 expression and the activation of pro- @entity1476 , and via modulating their inhibitors, @entity16617 , and @entity2289 .

title: XXXX inhibit @entity7 / @entity540 -induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.

answer: @entity3088 :: (MESH:D005419,Chemical) :: ['Flavonoids']


abstract: @entity3088 have been proposed to act as chemopreventive agents in numerous epidemiological studies and have been shown to inhibit angiogenesis and proliferation of @entity5 cells and endothelial cells in vitro. Angiogenesis requires tightly controlled extracellular matrix degradation mediated by extracellular proteolytic enzymes including matrix metalloproteinases (MMPs) and @entity563 proteases, in particular, the urokinase-type plasminogen activator ( @entity2290 )-plasmin system. In this study, we have investigated the antiangiogenic mechanism of the @entity3088 , @entity670 , @entity15476 , and @entity21538 in a @entity1 umbilical vein endothelial cell (HUVEC) model. The stimulation of serum-starved HUVECs with vascular endothelial growth factor/basic fibroblast growth factor ( @entity23625 ) caused marked increase in @entity3334 production and induced the pro- @entity1476 activation accompanied by the increase in @entity1551 expression. However, pretreatment with @entity3088 before @entity7 / @entity540 stimulation completely abolished the @entity7 / @entity540 -stimulated increase in @entity3334 and @entity1551 expression and pro- @entity1476 activation. @entity670 blocked @entity7 / @entity540 -stimulated increase in @entity2843 expression and decrease in @entity1552 expression. @entity15476 and @entity21538 further decreased @entity2843 expression below basal level and completely abolished @entity1552 expression. @entity7 and @entity540 stimulation also significantly induced @entity2290 expression, most strikingly the level of 33 kDa @entity2290 , and increased the expression of @entity2289 . @entity670 , @entity15476 , and @entity21538 effectively blocked the generation of 33 kDa @entity2290 , and further decreased the activity of the 55 kDa @entity2290 and the expression of @entity2289 below the basal level. In conclusion, these data suggest that @entity670 , @entity15476 , and @entity21538 inhibit in vitro angiogenesis, in part via preventing @entity7 / @entity540 -induced @entity3334 and @entity2290 expression and the activation of pro- @entity1476 , and via modulating their inhibitors, @entity16617 , and @entity2289 .

title: @entity3088 inhibit @entity7 / XXXX -induced angiogenesis in vitro by inhibiting the matrix-degrading proteases.

answer: @entity540 :: (2247,Gene) :: ['bFGF']


abstract: OBJECTIVE: The @entity1 with @entity5 after the radiation, chemical and operative therapies were often not able to get effective treatment because their lesions involved in the nervous and vascular structure and the re-radiation therapy was not suitable or chemical therapy was not sensitive to the @entity5 as well. To improve their survival quality, prevent the fatal complication and prolong their life, the surgical treatment for them was advised. METHOD: Six @entity1 were treated surgically. According to the lesion of extension and position, the different incisions were respectively made. The @entity5 of these @entity1 were resected piece by piece because they usually involved in the important structures, such as the internal carotid artery and cavernous sinus. Then, local defect was repaired with different methods on basis of the individual condition. So, this type of operation could be called as non-defined operation. RESULTS: The lesions in all 6 @entity1 invaded the eye, meninges and encephala, skull base, cavernous sinus and other important structures. After surgical intervene, the @entity1 were all more than one year survival except for one of the @entity1 who died of serous bleeding with @entity3538 . Three @entity1 survived for 4, 5 and 12 years, respectively. CONCLUSION: The craniofacial recurrent @entity189 in late stage could be resected by the non-defined operation, which could prolong the @entity1 life and achieve the desired effect.

title: [Surgical treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3538 :: ('MESH:D002341', 'Disease') :: ['corrupted rupture of internal carotid artery']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'craniofacial recurrent cancers', 'neoplasms']

answer: @entity189 :: (MESH:D002277,Disease) :: ['craniofacial recurrent carcinoma']


abstract: BACKGROUND: Few studies have suggested that routine bone marrow (BM) and cerebrospinal fluid (CSF) evaluation is not needed in all @entity1 with @entity995 . Although the International @entity995 Staging System was developed recently, there remain no clear stage-specific guidelines with regard to the need for BM and CSF evaluations as part of the metastatic workup for @entity1 with @entity995 . METHODS: This is a retrospective study analyzing results of CSF cytology and BM evaluation at presentation/diagnosis in @entity1 with @entity995 registered at our center from June, 2003 to June, 2009. Only cases with both BM biopsy and lumbar puncture were included. RESULTS: Of the 259 evaluable @entity1 , 18 (7%) were positive for @entity3 either in CSF and/or BM. Although 7 of these had overt @entity3 at presentation (stage IV), 1 belonged to stage II and 10 to stage IIIa. No stage 0 or I @entity1 tested positive despite presence of histopathologic high-risk factors. CONCLUSIONS: This is the largest study evaluating the role of metastatic workup in @entity1 with @entity995 at presentation. We conclude that CSF and BM evaluation is not required in @entity1 with stage 0 and I @entity995 at presentation. No definitive recommendation could be made for stage II @entity1 ; while stage III and IV @entity1 must certainly be evaluated.

title: Bone marrow aspirations and lumbar punctures in XXXX at diagnosis: correlation with IRSS staging.

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['Retinoblastoma', 'retinoblastoma']

answer: @entity995 :: (MESH:D012175,Disease) :: ['retinoblastoma']


abstract: PURPOSE: To study the efficacy of reirradiation as salvage treatment in @entity1 with locally recurrent @entity189 . @entity1 AND METHODS: Between 1993 and 2000, 20 consecutive @entity1 (twelve males and eight females) with @entity5 , previously irradiated in different Hungarian institutions, were reirradiated for biopsy-proven locally recurrent @entity5 . Histologically, 85% of the @entity1 had WHO type III, 5% type II, and 10% type I disease. Stages I-IV (AJCC 1997 staging system) were assigned to five (25%), seven (35%), five (25%), and three (15%) @entity1 , respectively; none of them had distant metastases, and only eight (40%) displayed regional dissemination. The median time period between termination of primary treatment and local recurrence was 30 (range, 10-204) months. Brachytherapy was the method most frequently used: in ten cases alone (especially for rT1 @entity5 ), and in eight cases in combination with external beam therapy. Two @entity1 with locally advanced disease underwent external beam therapy only. The median dose in the event of brachytherapy alone was 20 Gy (4 x 5 Gy or 5 x 4 Gy, range, 16-36 Gy), and the dose range for exclusive external irradiation was 30-40 Gy. In cases of combined irradiation, a median 20-Gy brachytherapy (range, 16-40 Gy) was associated with 30-40 Gy of external irradiation. Radiotherapy was supplemented by neck dissection (six @entity1 ), nasopharyngectomy (one @entity1 ), or chemotherapy (eleven @entity1 ). RESULTS: 16 @entity1 were reirradiated once, three twice, and one @entity1 three times, with a median equivalent dose for @entity5 effect of 36 Gy (mean, 44 Gy; range, 19-117 Gy; the estimated alpha/beta-ratio was 10 Gy). The median equivalent dose of reirradiation for late effect on normal tissue (with an estimated 70% delivery of the @entity5 dose) amounted to 30 Gy (mean, 37 Gy; range, 13-101 Gy, estimated alpha/beta-ratio 3 Gy). After a median follow-up of 37 (range, 12-72) months, the overall survival was 60% (12/20). Seven of the twelve surviving @entity1 are currently @entity5 -free. After primary irradiation, xerostomy occurred in all @entity1 as an unavoidable side effect of treatment. Following reirradiation, a severe (grade 3 or higher) late @entity137 (CTC criteria, version 2) has been observed in two @entity5 -free @entity1 (10%) so far ( @entity39 of soft palate and paresis of glossopharyngeal nerve). CONCLUSION: Retreatment of @entity189 with radiotherapy (preferably a combined modality), can result in longterm local control and survival in a substantial proportion of @entity1 , at the price of an acceptable morbidity.

title: Reirradiation of locally recurrent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'nasopharyngeal cancer', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma']

answer: @entity189 :: (MESH:D002277,Disease) :: ['nasopharyngeal carcinoma']


abstract: BACKGROUND: Survival data of @entity703 ( @entity703 ) registered in SIOP trials, advocating preoperative chemotherapy, are not available. AIM: To evaluate characteristics, response and survival of @entity703 @entity1 registered in recent SIOP protocols. METHODS: An evaluation of all @entity703 @entity1 treated from 1993 to 2005 (SIOP trials 93-01 and 2001) was performed. Data were obtained from study specific case record forms and entered centrally in a database. RESULTS: Hundred and seven @entity1 were identified (57 male), with a median age at diagnosis of 13 months (interquartile range 6-27 months), and a median follow-up time of 60 months. Left and right kidneys were equally affected. @entity5 stage distribution was stage I (6%), stage II (22%), stage III (43%), stage IV (22%) and stage V (3%). Stage IV @entity1 included 17 with @entity358 (8 lung-only) and 12 with multiple organ metastases (bone, brain and liver). Primary surgery was the upfront treatment approach in 22/107 @entity1 (21%), by which 19 @entity1 reached a complete remission (CR). Median difference in @entity5 volume before and after preoperative chemotherapy was 69 ml (interquartile range: 4.5-158.0, P < 0.0001), indicating marked chemosensitivity. The 5-year event-free survival (EFS) of the total group was 22% (95% CI: 15-33) and overall survival 26% (95% CI: 18-37). Most events (86%) occurred within the first 2 years after diagnosis. Younger age at diagnosis was an important adverse prognostic factors for survival. In contrast, @entity5 volume at diagnosis, nor volume reduction was associated with outcome. CONCLUSION: @entity703 has a poor outcome especially in young and advanced-stage disease @entity1 . Neither @entity5 volume at diagnosis, nor pre-operative chemosensitivity are prognostic factors for survival.

title: @entity5 of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the XXXX study group.

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary metastasis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumour', 'tumour']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['MRTK', 'malignant rhabdoid tumour of the kidney']

answer: @entity703 :: (MESH:D007680,Disease) :: ['SIOP renal tumour']


abstract: BACKGROUND: Survival data of @entity703 ( @entity703 ) registered in SIOP trials, advocating preoperative chemotherapy, are not available. AIM: To evaluate characteristics, response and survival of @entity703 @entity1 registered in recent SIOP protocols. METHODS: An evaluation of all @entity703 @entity1 treated from 1993 to 2005 (SIOP trials 93-01 and 2001) was performed. Data were obtained from study specific case record forms and entered centrally in a database. RESULTS: Hundred and seven @entity1 were identified (57 male), with a median age at diagnosis of 13 months (interquartile range 6-27 months), and a median follow-up time of 60 months. Left and right kidneys were equally affected. @entity5 stage distribution was stage I (6%), stage II (22%), stage III (43%), stage IV (22%) and stage V (3%). Stage IV @entity1 included 17 with @entity358 (8 lung-only) and 12 with multiple organ metastases (bone, brain and liver). Primary surgery was the upfront treatment approach in 22/107 @entity1 (21%), by which 19 @entity1 reached a complete remission (CR). Median difference in @entity5 volume before and after preoperative chemotherapy was 69 ml (interquartile range: 4.5-158.0, P < 0.0001), indicating marked chemosensitivity. The 5-year event-free survival (EFS) of the total group was 22% (95% CI: 15-33) and overall survival 26% (95% CI: 18-37). Most events (86%) occurred within the first 2 years after diagnosis. Younger age at diagnosis was an important adverse prognostic factors for survival. In contrast, @entity5 volume at diagnosis, nor volume reduction was associated with outcome. CONCLUSION: @entity703 has a poor outcome especially in young and advanced-stage disease @entity1 . Neither @entity5 volume at diagnosis, nor pre-operative chemosensitivity are prognostic factors for survival.

title: XXXX of the kidney (MRTKs), registered on recent SIOP protocols from 1993 to 2005: a report of the @entity703 study group.

answer: @entity5 :: (MESH:D009369,Disease) :: ['Malignant rhabdoid tumours']


abstract: In order to further improve and explore the role of lasers for nerve reconstruction, this study was designed to investigate regeneration of sharply transected peripheral nerves repaired with a @entity515 milliwatt laser in combination with three different suture materials and a @entity291 albumin protein solder as an adjunct to the welding process. Unilateral sciatic nerve repair was performed in 44 @entity35 . In the laser group, nerves were gently apposed, and two stay sutures (10-0 nylon, 10-0 @entity6886 , or 25 microm stainless steel) were placed epi/perineurially. Thereafter, the repair site was fused at 100 mW with pulses of 1.0 s. In the subgroup of laser-assisted nerve repair (LANR), albumen was used as a soldering agent to further reinforce the repair site. The control group consisted of nerves repaired by conventional microsurgical suture repair (CMSR), using 4-6 10-0 nylon sutures. Evaluation was performed at 1 and 6 weeks after surgery, and included qualitative and semiquantitative light microscopy. LANR performed with a protein solder results in a good early peripheral nerve regeneration, with an optimal alignment of nerve fibers and minimal connective tissue proliferation at the repair site. All three suture materials produced a foreign body reaction; the least severe was with @entity6886 sutures. CMSR resulted in more pronounced @entity6401 at the repair site, with more connective-tissue proliferation and axonal misalignment. Furthermore, axonal regeneration in the distal nerve segment was better in the laser groups. Based on these results, @entity515 laser-assisted nerve repair with soldering in combination with absorbable sutures has the potential of allowing healing to occur with the least foreign-body reaction at the repair site. Further experiments using this combination are in progress.

title: Carbon dioxide laser-assisted nerve repair: effect of solder and suture material on nerve regeneration in XXXX sciatic nerve.

entities_list: @entity6886 :: ('CHEBI:53492', 'Chemical') :: ['polyglycolic acid']

entities_list: @entity6401 :: ('MESH:D015745', 'Disease') :: ['foreign-body granulomas']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVES: @entity544 laser-assisted endoscopic cricopharyngeal myotomy (ECPM) has emerged as a viable therapy for @entity1282 . The risks of the procedure include pharyngoesophageal perforation and @entity1764 , which may discourage adoption of this technique. To address these complications, we examined outcomes of ECPM with primary mucosal closure. METHODS: A case series of 7 @entity1 who underwent ECPM between 2006 and 2008 were reviewed for length of operation, length of hospitalization, @entity260 , and outcomes by use of the M. D. Anderson @entity1282 Index (MDADI) and the Functional Outcome Swallowing Scale (FOSS). The results were compared to those of a control group of 7 @entity1 treated during the same period via open cricopharyngeal myotomy. RESULTS: All @entity1 who had ECPM were treated successfully without complications. The operative times averaged 128 minutes. The hospitalization averaged 2.1 days. Statistically significant improvements in swallowing were seen (MDADI score from 51.3 to 77.7, p < 0.0006; FOSS score from 3.7 to 1.3, p < 0.0005), and were similar to those in the @entity1 who had the open procedure (FOSS score from 3.0 to 1.0, p <0.006). Trends toward decreased @entity190 , a shorter hospital stay, and a lower complication rate were observed in the @entity1 who had ECPM. CONCLUSIONS: ECPM is beneficial as a primary treatment for @entity409 . Closure of the @entity33 may help reduce the incidence of postoperative cervical @entity2415 and @entity1764 , and does not appear to compromise functional outcome.

title: XXXX laser-assisted endoscopic cricopharyngeal myotomy with primary mucosal closure.

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['cricopharyngeal dysfunction']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal defect']

entities_list: @entity1764 :: ('MESH:D008480', 'Disease') :: ['mediastinitis']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity2415 :: ('MESH:D004646', 'Disease') :: ['emphysema']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['Dysphagia', 'dysphagia']

entities_list: @entity544 :: ('MESH:D002245', 'Chemical') :: ['Carbon dioxide']

answer: @entity544 :: (MESH:D002245,Chemical) :: ['Carbon dioxide']


abstract: A comparative study of right ventricular histopathologic findings and clinical profiles in 174 cases with @entity1121 ( @entity1121 ), 145 cases with @entity384 ( @entity384 ), and 241 cases with idiopathic @entity943 and/or conduction disturbance with significant myocardial pathology [Electric disturbance type of @entity296 ( @entity14315 )], totaling 560 cases, was made in order to clarify the role of @entity2401 in these conditions. @entity1987 ( @entity1987 ) was defined by assessing serial biopsy findings in nine cases with @entity2401 . The @entity1987 was observed in three cases with @entity1121 (1.7%), 22 with @entity384 (15%), and 21 with @entity14315 (8.7%). The incidence of @entity1987 was significantly higher in @entity384 and @entity14315 than in @entity1121 (P less than 0.001). The typical pattern of onset of @entity2401 , i.e., high fever, @entity1729 , and gastrointestinal symptoms preceding @entity299 within 10 days, was recognized in one case with @entity1121 , eight with @entity384 , and 6 of 123 cases with @entity14315 . The incidence was higher in @entity384 and @entity14315 than in @entity1121 (P less than 0.05). Of 46 cases with @entity1987 , 12 (26%) showed this pattern, on the other hand only 3 of 377 cases (0.8%) without @entity1987 did so (P less than 0.0001). Familial occurrence was not found in any of the 46 cases with @entity1987 but was found in 38 of the 377 cases without @entity1987 (P less than 0.01). This study indicates that @entity2401 may often be the causative agent of @entity296 , especially @entity384 and @entity14315 . It is also noticed that familial occurrence of the cases with @entity1987 was never seen.

title: A clinicopathologic study on a cause of XXXX and @entity943 and conduction disturbance employing endomyocardial biopsy.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['idiopathic cardiomyopathy', 'cardiomyopathy']

entities_list: @entity1987 :: ('MESH:D009402', 'Disease') :: ['PMC', 'Postmyocarditis change']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'dilated cardiomyopathy']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['upper respiratory infection']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac symptoms']

entities_list: @entity1121 :: ('MESH:D002312', 'Disease') :: ['HCM', 'hypertrophic cardiomyopathy']

entities_list: @entity2401 :: ('MESH:D009205', 'Disease') :: ['viral myocarditis', 'acute myocarditis']

answer: @entity296 :: (MESH:D009202,Disease) :: ['idiopathic cardiomyopathy']


abstract: A comparative study of right ventricular histopathologic findings and clinical profiles in 174 cases with @entity1121 ( @entity1121 ), 145 cases with @entity384 ( @entity384 ), and 241 cases with idiopathic @entity943 and/or conduction disturbance with significant myocardial pathology [Electric disturbance type of @entity296 ( @entity14315 )], totaling 560 cases, was made in order to clarify the role of @entity2401 in these conditions. @entity1987 ( @entity1987 ) was defined by assessing serial biopsy findings in nine cases with @entity2401 . The @entity1987 was observed in three cases with @entity1121 (1.7%), 22 with @entity384 (15%), and 21 with @entity14315 (8.7%). The incidence of @entity1987 was significantly higher in @entity384 and @entity14315 than in @entity1121 (P less than 0.001). The typical pattern of onset of @entity2401 , i.e., high fever, @entity1729 , and gastrointestinal symptoms preceding @entity299 within 10 days, was recognized in one case with @entity1121 , eight with @entity384 , and 6 of 123 cases with @entity14315 . The incidence was higher in @entity384 and @entity14315 than in @entity1121 (P less than 0.05). Of 46 cases with @entity1987 , 12 (26%) showed this pattern, on the other hand only 3 of 377 cases (0.8%) without @entity1987 did so (P less than 0.0001). Familial occurrence was not found in any of the 46 cases with @entity1987 but was found in 38 of the 377 cases without @entity1987 (P less than 0.01). This study indicates that @entity2401 may often be the causative agent of @entity296 , especially @entity384 and @entity14315 . It is also noticed that familial occurrence of the cases with @entity1987 was never seen.

title: A clinicopathologic study on a cause of @entity296 and XXXX and conduction disturbance employing endomyocardial biopsy.

answer: @entity943 :: (MESH:D001145,Disease) :: ['arrhythmia']


abstract: BACKGROUND: Recent studies have reported the association of gamma-glutamyltransferase ( @entity53139 ) or ferritin with @entity209 . However, there has been no large population-based study assessing the interrelationship of these two biomarkers and their association with @entity2690 resistance. METHODS: A population-based cross-sectional study was carried out in the Chinese Liangshan Yi ethnic group. 756 eligible subjects, aged 20 - 74 years, were included. Demographic characteristics, medical history, and lifestyle data were collected through questionnaires. An oral @entity413 tolerance test was performed. Laboratory tests, including @entity53139 and ferritin measurements, were conducted. Spearman's rank-order correlation and multiple linear regression were used to calculate the correlation of @entity53139 with ferritin and their relationship to the @entity2690 resistance index determined by the homeostasis model assessment (HOMA-IR). RESULTS: A significant correlation between serum @entity53139 and ferritin levels was found (r = 0.393, p < 0.05). @entity53139 was independently correlated with ferritin after adjustment for age, gender, place of residence, education, income, leisure-time physical activity, drinking, smoking, body mass index, systolic pressure, diastolic pressure, @entity23109 , @entity10745 , @entity5906 aminotransferase, @entity3929 aminotransferase, total @entity165 , low density lipoprotein- @entity165 , @entity412 , high density lipoprotein- @entity165 , fasting plasma @entity413 , 2-hour postprandial plasma @entity413 , @entity414 , and urinary albumin to @entity1011 ratio (p < 0.05). Positive correlations were established between @entity53139 (standard b = 0.252) or ferritin (standard b = 0.181) after adjustment for multiple confounders (p < 0.05). CONCLUSIONS: @entity2690 resistance is associated with elevated serum @entity53139 and ferritin. A combined determination of @entity53139 and ferritin might lead to better predictions in @entity1 with @entity2690 resistance.

title: Serum Gamma-Glutamyltransferase and Ferritin are Related to XXXX Resistance: A Population-Based Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity23109 :: ('MESH:D006514', 'Chemical') :: ['hepatitis B surface antigen']

entities_list: @entity10745 :: ('MESH:D006526', 'Disease') :: ['anti-hepatitis C virus']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

answer: @entity2690 :: (3630,Gene) :: ['Insulin']


abstract: BACKGROUND: Chemoresistance is a leading cause of treatment failure in advanced @entity2 , including that with the extensively prescribed @entity1311 . Recently, a series of structurally unique @entity17205 ( @entity17205 ) that act as antagonists of inhibitor of apoptosis proteins (IAPs) have been discovered, exhibiting the ability of inducing enhanced apoptosis of various @entity5 cell types when combined with chemotherapy. In the present study, we synthesized the second mitochondria-derived activator of caspase peptide ( @entity17205 -N7 for short) and explored its capacity in combination with @entity1311 in vitro. METHODS: The sensitivity assay and reversal ability of @entity17205 -N7 were tested by @entity98 . Flow cytometry was used to analyze apoptosis of cells with @entity4404 /PI double staining technique. Cell cloning ability was performed to reflect its biological behavior in each group. RESULTS: Concentrations with inhibitory rates < 10% were selected as the reversal value of @entity17205 -N7 peptide using @entity98 . The reversal folds were 2.52, 3.26, 3.67, and 5.4 in @entity1311 + @entity17205 -N7 (0.0390625, 0.078125, 0.15625, 0.3125  g/mL, respectively), and concentrations of @entity17205 -N7 and reversal folds appeared in an obvious positive correlation (r(s) = 1, p = 0.000). Apoptosis analyzed at 48 hours by flow cytometry showed the apoptotic rates in @entity1311 and 0.0390625, 0.078125, 0.15625, and 0.3125  g/mL @entity17205 -N7 + @entity1311 groups were 15.4    1.09%, 20.8%    2.18%, 28.4%    4.17%, 37.64%    6.41%, and 46.6%    7.76%, respectively. Concentrations of @entity17205 -N7 appeared to have negative correlations with PE and SF (r(s) = -1, p < 0.05), which showed that the cells' cloning ability in 0.3125  g/mL @entity17205 -N7 + @entity1311 group was worse than that of other groups. CONCLUSIONS: When combined with @entity1311 , 0.3125  g/mL @entity17205 -N7 peptide may significantly increase @entity1311 -induced apoptosis in chemoresistant A549/ @entity1311 lung cells at 48 hours, and is potentially useful as a reversal agent in @entity2 therapy.

title: Reversal of Chemoresistance in Human Lung Cancer Cell Line A549/ XXXX by Synthetic Second Mitochondria-Derived Activator of Caspase Peptide.

entities_list: @entity17205 :: ('56616', 'Gene') :: ['Smac', 'second mitochondria-derived activators of caspase']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

answer: @entity1311 :: (MESH:D017239,Chemical) :: ['Taxol']


abstract: The @entity146 Inventory is a clinical instrument for assessing behavioral and psychological symptoms in @entity303 . It is based on an interview with the primary caregiver. A brief questionnaire form of the NPI was developed, intended for use in routine clinical practice (NPI-Q). This study evaluates the validity of the NPI-Q Dutch form. The NPI-Q was compared to other questionnaires, i.e. the Revised Memory and Behavioural Problems Checklist (RMBPC), the short form Informant Questionnaire on @entity73 in the Elderly (IQCODE-N), the 15 items Geriatric @entity308 Scale (GDS-15) and the Cognitive Screening Test (CST-20). A data set was used of geriatric outpatients who were referred for neuropsychological assessment (n = 29). Correlations between the NPI-Q and RMBPC @entity308 - and Disinhibition subscales were relatively high. No relationship was found between the NPI-Q and the RMBPC Memory related behavioral changes subscale, or between the NPI-Q and the IQCODE-N and the CST-20. Informant ratings on the NPI-Q depression-item were related with @entity1 ratings on the GDS-15, especially when @entity1 were relatively mildly @entity73 . Caregiver distress was strongly associated with NPI-Q symptom assessment. IN CONCLUSION: our preliminary results support validity of the NPI-Q Dutch form. It is a practical rating scale for assessing @entity146 in @entity303 and associated caregiver distress.

title: [ XXXX inventory questionnaire (NPI-Q): A validity study of the Dutch form].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric symptoms', 'Neuropsychiatric']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['Cognitive Decline', 'cognitive impaired']

answer: @entity146 :: (MESH:D001523,Disease) :: ['Neuropsychiatric']


abstract: Alcohol intolerance after consumption of wild mushrooms is a recognized phenomenon. This is best understood with Coprinus atramentarius. Its active component @entity72531 blocks enzymatic @entity1068 degradation at the stage of @entity3094 , which is responsible for the well-recognized symptoms. Here, we report three events in five @entity1 experiencing the same symptoms after consumption of self-collected Lepiota aspera. All had mistaken L. aspera for edible mushrooms as Amanita rubescens or Macrolepiota procera. In all events, L. aspera was identified by mycologists and no other mushrooms were involved. The mushrooms were well saut  ed and tolerated well until an alcoholic beverage was consumed. Then within few minutes facial flushing, throbbing @entity10 , @entity591 , and @entity1353 all occurred. The symptoms abated within a few hours with no sequelae but could be re-provoked by further @entity167 consumption up to 48 h later. This syndrome appears to be identical with the one known from C. atramentarius. However, the toxin in L. aspera or its mechanism is not yet known.

title: Case series: @entity167 intolerance with XXXX -like syndrome after consumption of the mushroom Lepiota aspera (Pers.:Fr.) Qu  l., 1886 (Freckled Dapperling).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity72531 :: ('CHEBI:3875', 'Chemical') :: ['Coprine']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity3094 :: ('MESH:D000079', 'Chemical') :: ['acetaldehyde']

answer: @entity72531 :: (CHEBI:3875,Chemical) :: ['Coprine']


abstract: Alcohol intolerance after consumption of wild mushrooms is a recognized phenomenon. This is best understood with Coprinus atramentarius. Its active component @entity72531 blocks enzymatic @entity1068 degradation at the stage of @entity3094 , which is responsible for the well-recognized symptoms. Here, we report three events in five @entity1 experiencing the same symptoms after consumption of self-collected Lepiota aspera. All had mistaken L. aspera for edible mushrooms as Amanita rubescens or Macrolepiota procera. In all events, L. aspera was identified by mycologists and no other mushrooms were involved. The mushrooms were well saut  ed and tolerated well until an alcoholic beverage was consumed. Then within few minutes facial flushing, throbbing @entity10 , @entity591 , and @entity1353 all occurred. The symptoms abated within a few hours with no sequelae but could be re-provoked by further @entity167 consumption up to 48 h later. This syndrome appears to be identical with the one known from C. atramentarius. However, the toxin in L. aspera or its mechanism is not yet known.

title: Case series: XXXX intolerance with @entity72531 -like syndrome after consumption of the mushroom Lepiota aspera (Pers.:Fr.) Qu  l., 1886 (Freckled Dapperling).

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['Alcohol']


abstract: BACKGROUND: @entity9539 have shown promise as an adjunctive treatment for @entity161 . However, efficacy across studies has been inconsistent. We conducted a meta-analysis of published controlled studies with the goal of detecting different efficacy profiles at various stages of @entity161 . METHODS: An online search was conducted for randomized, double-blind, placebo-controlled clinical trials, and a meta-analysis was conducted. RESULTS: Ten studies met the criteria for inclusion. Among @entity1 in the prodromal phase of @entity161 , omega-3 supplementation reduced psychotic symptom severity and lowered conversion rates to first-episode @entity716 . In @entity1 with first-episode @entity161 , omega-3 decreased nonpsychotic symptoms, required lower antipsychotic medication dosages, and improved early treatment response rates. Omega-3 had mixed results in @entity1 with stable chronic @entity161 , with only some @entity1 experiencing significant benefits. Among @entity1 with chronic @entity161 , use of @entity9539 both by those experiencing acute exacerbations and those who had discontinued antipsychotic medications resulted in worsening of @entity716 . CONCLUSIONS: The data suggest that @entity9539 may be efficacious in reducing clinical symptoms for @entity1 in the earlier stages of @entity161 (prodrome and first episode), while producing mixed results for @entity1 in the chronic stages. Based on these results, @entity9539 would not be recommended for acute exacerbations in @entity1 with chronic @entity161 nor for relapse prevention after discontinuation of antipsychotics.

title: A meta-analysis of placebo-controlled trials of omega-3 fatty acid augmentation in XXXX : Possible stage-specific effects.

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis', 'psychotic symptoms']

entities_list: @entity9539 :: ('MESH:D015525', 'Chemical') :: ['Omega-3 fatty acids', 'omega-3 fatty acids']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: @entity447 is characterized by the occurrence of frequent spontaneous @entity548 . If inadequately treated, it results in progressive @entity121 leading to @entity85 . These complications result in lifelong chronic @entity158 and disability that may greatly affect the @entity1 ' mood. We aimed to evaluate the musculoskeletal function in our @entity447 @entity1 and its correlation to depressed mood in these @entity1 and determine the impact of degree of @entity447 , different replacement therapy regimens and frequency of @entity5631 , on both musculoskeletal function and mood. A cross-sectional study was carried out on 50 adolescent @entity447 @entity1 . Musculoskeletal function was assessed using Functional Independence Score for @entity447 (FISH) and mood status was assessed using Beck Depression Inventory-Short Form (BDI-SF). The mean FISH score was 23.32    4.69 (range 13-28) and the tasks that obtained lower scores were step climbing, squatting and walking. Of our 50 @entity1 included, 16(32%) were not depressed, 18(36%) were with mild @entity308 , 11(22%) were with moderate @entity308 and 5(10%) were with severe @entity308 . There was a highly significant negative correlation between mean FISH score and mean BDI-SF score (P < 0.001). The better the replacement therapy regimen, the better the musculoskeletal function that could be obtained in @entity447 @entity1 and the better the mood.

title: Assessment of musculoskeletal function and mood in XXXX adolescents: a cross-sectional study.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intra-articular and intramuscular bleeding']

entities_list: @entity447 :: ('MESH:D006467', 'Disease') :: ['Haemophilia A', 'haemophilia A', 'factor VIII deficiency', 'Hemophilia']

entities_list: @entity5631 :: ('MESH:D006395', 'Disease') :: ['hemarthrosis']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['crippling deformities and musculoskeletal dysfunction']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['damage to joints and muscles']

answer: @entity447 :: (MESH:D006467,Disease) :: ['haemophilia A']


abstract: AIM: Percutaneous @entity439 repair (p-EVAR), has been widely spread based on the recent improvements in stent-graft technology and mainly in delivery system downsizing. Aim of this study is to investigate the safety and efficacy of fascia suture technique (FST) in p-EVAR during the short and mid-term follow up (FU). METHODS: Between April 2011 and July 2013, 64 consecutive @entity1 with @entity1028 were enrolled in a prospective single center registry. 54 @entity1 were eligible for elective p-EVAR assisted by the fascia suture technique. @entity1 were prospectively followed with duplex scan 24 hours and 30 days postoperatively and with CTA annually thereafter. Femoral haematoma, @entity2849 and limb ischaemia were the primary outcomes. RESULTS: The study investigated 103 femoral arteries reconstructions using the FST. Intraoperatively, one @entity1 was diagnosed with limb ischaemia treated with open repair. During the short-term, 4 (3.8%) @entity2849 were diagnosed, treated with open (2) or endovascular (2) repair. During mid-term 43 @entity1 (85 arteries) 82,6% underwent CTA. Eighteen (17.4%) @entity1 were lost of FU. At 12 months CTA two @entity2849 (2.35%) were detected, treated with open repair. CONCLUSION: The FST seems safe and effective for femoral reconstruction after p- EVAR. Complications are comparable to closure devices and to conventional repair.

title: XXXX repair with Fascia suture technique: short and mid- term results.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['endovascular aneurysm']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm', 'pseudoaneurysms']

answer: @entity439 :: (MESH:D000783,Disease) :: ['Endovascular aneurysm']


abstract: Following the discovery of a @entity1002 ( @entity1002 ), the classical approach consists of treatment with non-fractionated heparin (NFH) followed by oral anticoagulants. The use of NFH for this indication has only been evaluated in one open, non randomised study of 23 @entity1 with no control group. Low molecular weight heparins (LMWH) have not been the object of any study although they are routinely used by certain teams. The objective of this study was to evaluate the feasibility of the use of LMWH in the treatment of @entity1002 . This was an open, non randomised prospective study. All @entity1 having a newly diagnosed @entity1002 between September 2000 and September 2002 were treated with @entity2120 (100 IU/kg twice daily) for an average duration of 13 days; replacement with @entity35538 was started on the fifth day. The progression of the @entity1002 was followed using twice weekly transthoracic echocardiography for 3 weeks. RESULTS: 19 @entity1002 were discovered in 2 years (13 complicating an anterior @entity1188 and 6 with a @entity384 ). The average area was between 2.64 +/- 0.41 cm2 and 0.43 +/- 0.21 cm2 (p < 0.0001). Thirteen out of 19 thrombi disappeared with treatment (68.5%). There was no @entity882 or @entity548 . One transient ischaemic attack was noted. CONCLUSION: This preliminary work shows that LMWH are well tolerated and effective to make a @entity715 disappear or to reduce its size.

title: [Treatment of left intraventricular XXXX with low molecular weight heparin].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage']

entities_list: @entity35538 :: ('MESH:C017673', 'Chemical') :: ['fluindione']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity2120 :: ('MESH:D017984', 'Chemical') :: ['enoxaparine']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left intra ventricular thrombus', 'LIVT']

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombosis']