abstract: @entity5 are rare @entity5 displaying two distinct cell populations developing in juxtaposition to one another without areas of intermingling. They are rare entities with only 63 cases described in English literature. @entity5 encountered are @entity356 colliding with @entity706 , @entity674 , @entity957 , and @entity5 . Their cell origin is obsolete by the time of diagnosis. Different tumorigenesis theories have been suggested to explain their behavior, yet none has managed to provide satisfactory explanation for all cases. Clinically they are indistinguishable from the dominant @entity5 . Lack of data does not allow detailed assessment of their behavior yet they seem aggressive @entity5 with dismal prognosis. The majority of cases have been diagnosed postoperatively during histologic examination of specimens. There are no guidelines or concrete evidence to support best way of adjuvant or other types of treatment. However, these rare @entity5 might help in unlocking secrets of @entity5 behavior including tumorigenesis, differentiation, and adhesion and thus clinicians should be aware of their existence.

title: XXXX : an insight into their origin and clinical significance.

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors', 'cancer', 'neuroendocrine tumors', 'Collision tumors', 'neoplasms']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity674 :: ('MESH:D046152', 'Disease') :: ['gastrointestinal stromal tumors']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric adenocarcinomas']

answer: @entity356 :: (MESH:D013274,Disease) :: ['Gastric collision tumors']


abstract: BACKGROUND: @entity890 ( @entity890 ) and @entity2649 ( @entity2649 ) are the most common diagnoses of low back and leg @entity158 symptoms. This study aimed to cross-culturally translate, and validate the Core Outcome Measures Index (COMI) in Iran. METHODS: The translation and cross-cultural adaptation of the original questionnaire were performed in accordance with published guidelines. A total of 121 @entity1 with @entity890 or @entity2649 were asked to respond to the questionnaire at two points in time: Pre and postoperative assessments (6 months follow-up). The @entity717 Index (ODI) also was completed. To test the reliability, the internal consistency was assessed by Cronbach's alpha coefficient, and validity was assessed using convergent validity. Responsiveness to change also was assessed for comparing @entity1 ' pre and postoperative scores. RESULTS: The Cronbach's alpha coefficients for the COMI at pre and postoperative assessments ranged from 0.79 to 0.82, indicating a good internal consistency. The change in the ODI after surgery was strongly correlated with change in the COMI, lending support to its good convergent validity (r = 0.79 for @entity890 and r = 0.77 for @entity2649 ; P < 0.001). In addition, the correlation of each item with its hypothesized subscale of the COMI showed satisfactory results suggesting, that the items had a substantial association with the subscale, representing the concept. Further analysis also indicated that the questionnaire was responsive to change (P < 0.0001). CONCLUSION: The Iranian version of COMI performed well, and the findings suggest that it is a reliable and valid measure of back @entity158 treatment evaluation among @entity890 and lumbar canal @entity850 @entity1 .

title: An outcome measure of functionality and XXXX in @entity1 with low back disorder: A validation study of the Iranian version of Core Outcome Measures Index.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2649 :: ('MESH:C563613', 'Disease') :: ['Lumbar Spinal Stenosis', 'LSS']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity890 :: ('MESH:D007405', 'Disease') :: ['Lumbar Disc Herniation', 'LDH']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: BACKGROUND: @entity890 ( @entity890 ) and @entity2649 ( @entity2649 ) are the most common diagnoses of low back and leg @entity158 symptoms. This study aimed to cross-culturally translate, and validate the Core Outcome Measures Index (COMI) in Iran. METHODS: The translation and cross-cultural adaptation of the original questionnaire were performed in accordance with published guidelines. A total of 121 @entity1 with @entity890 or @entity2649 were asked to respond to the questionnaire at two points in time: Pre and postoperative assessments (6 months follow-up). The @entity717 Index (ODI) also was completed. To test the reliability, the internal consistency was assessed by Cronbach's alpha coefficient, and validity was assessed using convergent validity. Responsiveness to change also was assessed for comparing @entity1 ' pre and postoperative scores. RESULTS: The Cronbach's alpha coefficients for the COMI at pre and postoperative assessments ranged from 0.79 to 0.82, indicating a good internal consistency. The change in the ODI after surgery was strongly correlated with change in the COMI, lending support to its good convergent validity (r = 0.79 for @entity890 and r = 0.77 for @entity2649 ; P < 0.001). In addition, the correlation of each item with its hypothesized subscale of the COMI showed satisfactory results suggesting, that the items had a substantial association with the subscale, representing the concept. Further analysis also indicated that the questionnaire was responsive to change (P < 0.0001). CONCLUSION: The Iranian version of COMI performed well, and the findings suggest that it is a reliable and valid measure of back @entity158 treatment evaluation among @entity890 and lumbar canal @entity850 @entity1 .

title: An outcome measure of functionality and @entity158 in XXXX with low back disorder: A validation study of the Iranian version of Core Outcome Measures Index.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: This is a retrospective study from January 2002 to December 2012 analyzing the results of microsurgical clipping for @entity439 arising from the @entity76 ( @entity76 ). MATERIALS AND METHODS: All @entity1 with @entity76 were evaluated with computerized tomography angiography and/or digital subtraction angiography (DSA) prior to surgery. All @entity1 in our series underwent microsurgical clipping and postoperative DSA to assess the extent of @entity439 . The Glasgow outcome scale (GOS) and the modified Rankin's scale (mRS) were used to grade their postoperative neurological status at discharge and 6 months, respectively. RESULTS: Fourteen @entity1 had @entity76 @entity439 (ruptured-9, unruptured-5). There were 10 females and 4 males with the mean age of 47.2 years (median - 46 years, range = 24-66 years). @entity510 ( @entity510 ) was seen in 11 @entity1 . The mean duration of symptoms was 2.5 days (range = 1-7 days). The WFNS score at presentation was as follows: Grade 1 in 10 cases, II in 2 cases, III in 1 case and IV in 1 case. In the 9 cases with @entity1756 , average size of the @entity1756 was 7.3 mm (range = 2.5-27 mm, median = 4.9 mm). The subtemporal approach was used in the first 7 cases. The extradural temporopolar (EDTP) approach was used in the last 5 cases. Complications include @entity2553 (n = 6), @entity2895 (n = 5) and @entity1276 (n = 3). Two @entity1 died following surgery. At mean follow-up 33.8 months (median - 25 months, range = 19-96 months), no @entity1 had a rebleed. At discharge 9 (64%), had a GOS of 4 or 5 and 3 (21%) had a GOS of 3. At 6 months follow-up, 10/14 (71%) @entity1 had mRS of 0-2, and 2 (14%) had mRS of 5. CONCLUSIONS: @entity438 are uncommon and tend to rupture even when the @entity439 size is small (<7 mm). They commonly present with @entity510 . The EDTP approach avoids complication caused by temporal lobe retraction and injury to the vein of Labbe.

title: Microsurgical management of XXXX of the @entity76 - lessons learnt: An experience of 14 consecutive cases and review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['SAH', 'Subarachnoid hemorrhage']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['Aneurysms of the SCA']

entities_list: @entity2895 :: ('MESH:D015840', 'Disease') :: ['third nerve palsy']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm occlusion', 'aneurysm']

entities_list: @entity76 :: ('MESH:D002526', 'Disease') :: ['SCA', 'superior cerebellar artery']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['vasospasm']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured aneurysms', 'ruptured SCA aneurysm']

answer: @entity439 :: (MESH:D000783,Disease) :: ['aneurysms']


abstract: OBJECTIVE: This is a retrospective study from January 2002 to December 2012 analyzing the results of microsurgical clipping for @entity439 arising from the @entity76 ( @entity76 ). MATERIALS AND METHODS: All @entity1 with @entity76 were evaluated with computerized tomography angiography and/or digital subtraction angiography (DSA) prior to surgery. All @entity1 in our series underwent microsurgical clipping and postoperative DSA to assess the extent of @entity439 . The Glasgow outcome scale (GOS) and the modified Rankin's scale (mRS) were used to grade their postoperative neurological status at discharge and 6 months, respectively. RESULTS: Fourteen @entity1 had @entity76 @entity439 (ruptured-9, unruptured-5). There were 10 females and 4 males with the mean age of 47.2 years (median - 46 years, range = 24-66 years). @entity510 ( @entity510 ) was seen in 11 @entity1 . The mean duration of symptoms was 2.5 days (range = 1-7 days). The WFNS score at presentation was as follows: Grade 1 in 10 cases, II in 2 cases, III in 1 case and IV in 1 case. In the 9 cases with @entity1756 , average size of the @entity1756 was 7.3 mm (range = 2.5-27 mm, median = 4.9 mm). The subtemporal approach was used in the first 7 cases. The extradural temporopolar (EDTP) approach was used in the last 5 cases. Complications include @entity2553 (n = 6), @entity2895 (n = 5) and @entity1276 (n = 3). Two @entity1 died following surgery. At mean follow-up 33.8 months (median - 25 months, range = 19-96 months), no @entity1 had a rebleed. At discharge 9 (64%), had a GOS of 4 or 5 and 3 (21%) had a GOS of 3. At 6 months follow-up, 10/14 (71%) @entity1 had mRS of 0-2, and 2 (14%) had mRS of 5. CONCLUSIONS: @entity438 are uncommon and tend to rupture even when the @entity439 size is small (<7 mm). They commonly present with @entity510 . The EDTP approach avoids complication caused by temporal lobe retraction and injury to the vein of Labbe.

title: Microsurgical management of @entity439 of the XXXX - lessons learnt: An experience of 14 consecutive cases and review of the literature.

answer: @entity76 :: (MESH:D002526,Disease) :: ['superior cerebellar artery']


abstract: BACKGROUND: @entity2946 is a common @entity5 in the pediatric population, accounting for 25% of all childhood @entity1313 and relatively uncommon in adults. This review was to investigate treatment outcome and prognostic factors after treatment of @entity2946 . MATERIALS AND METHODS: A total of 53 @entity1 with histological confirmed @entity2946 cases treated at our institute between 2006 and 2012 were included in the study. Demographic variables, clinical variables, radiological findings and treatment details with respect to age, sex, signs and symptoms, location of @entity5 , extent of surgical resection, histopathology type, radiotherapy dose, follow-up period and outcomes were recorded. Survival was analyzed by using these parameters. RESULTS: Thirty-one (58.5%) @entity1 were pediatric (<14 years), and 22 (41.5%) @entity1 were adults (>= 14 years). Duration of symptoms were <3 months in 19 (36%) and more than 3 months in 34 (64%) @entity1 . @entity5 resection was performed in all @entity1 with gross total resection in 8 (15%) @entity1 , near total resection in 34 (64%) @entity1 and subtotal resection in 11 (21%) @entity1 . All @entity1 underwent postoperative craniospinal irradiation (CSI) delivering a median craniospinal dose of 36 Gy with additional boosts to the posterior fossa up to 54 Gy. Median overall survival was 50 months for the total group whereas 36 months for pediatric age group and 70 months for adult group. @entity2269 histology showed an improved outcome compared with other histologies with a median survival of 71 months compared with that of classical @entity2946 histology being 36 months and other histologies shown a median survival of 34 only. CONCLUSIONS: Treatment of @entity2946 with surgery and CSI yields long survival rates in both @entity1 and adults. Adult age group and desmoplastic histology were associated with a favorable outcome.

title: XXXX : A common @entity5 : Prognostic factors and predictors of outcome.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'malignancy']

entities_list: @entity2269 :: ('MESH:D058405', 'Disease') :: ['Desmoplastic']

entities_list: @entity2946 :: ('MESH:D008527', 'Disease') :: ['medulloblastoma', 'Medulloblastoma']

answer: @entity2946 :: (MESH:D008527,Disease) :: ['Medulloblastoma']


abstract: BACKGROUND: @entity2946 is a common @entity5 in the pediatric population, accounting for 25% of all childhood @entity1313 and relatively uncommon in adults. This review was to investigate treatment outcome and prognostic factors after treatment of @entity2946 . MATERIALS AND METHODS: A total of 53 @entity1 with histological confirmed @entity2946 cases treated at our institute between 2006 and 2012 were included in the study. Demographic variables, clinical variables, radiological findings and treatment details with respect to age, sex, signs and symptoms, location of @entity5 , extent of surgical resection, histopathology type, radiotherapy dose, follow-up period and outcomes were recorded. Survival was analyzed by using these parameters. RESULTS: Thirty-one (58.5%) @entity1 were pediatric (<14 years), and 22 (41.5%) @entity1 were adults (>= 14 years). Duration of symptoms were <3 months in 19 (36%) and more than 3 months in 34 (64%) @entity1 . @entity5 resection was performed in all @entity1 with gross total resection in 8 (15%) @entity1 , near total resection in 34 (64%) @entity1 and subtotal resection in 11 (21%) @entity1 . All @entity1 underwent postoperative craniospinal irradiation (CSI) delivering a median craniospinal dose of 36 Gy with additional boosts to the posterior fossa up to 54 Gy. Median overall survival was 50 months for the total group whereas 36 months for pediatric age group and 70 months for adult group. @entity2269 histology showed an improved outcome compared with other histologies with a median survival of 71 months compared with that of classical @entity2946 histology being 36 months and other histologies shown a median survival of 34 only. CONCLUSIONS: Treatment of @entity2946 with surgery and CSI yields long survival rates in both @entity1 and adults. Adult age group and desmoplastic histology were associated with a favorable outcome.

title: @entity2946 : A common XXXX : Prognostic factors and predictors of outcome.

answer: @entity5 :: (MESH:D009369,Disease) :: ['pediatric tumor']


abstract: Studies of tissue cell locomotion in culture have revealed much about cell motility, but whether behaviour in vitro resembles movement of the same cells in the animal is not clear. To investigate this, I compared the locomotion and cell-substratum contacts of epidermal cells from @entity1238 tadpoles, migrating from explants on glass and plastic, with the same cells spreading in vivo during wound closure. Time-lapse cinemicrography showed that in both cases, cells spread by extending broad lamellipodia across the substratum, and did not form microspikes, filopodia, or @entity4530 . The net rate of translocation was significantly slower in vitro, however, because cells both @entity71610 slower and spent more time stationary or withdrawing, compared with cells in situ. The increased fluctuation seemed in part due to greater @entity2701 within the expanding sheet in vitro, since when @entity2701 was reduced, for example by wounding, the cells spread with less fluctuation and at a greater rate (6.5 micrometers/min compared with 0.77 micrometers/min). Micromanipulation showed that cells adhered to the substratum, both in situ and in vitro, by a broad contact where @entity1579 ( @entity1579 ) of sectioned material showed the cells to be less than 30 nm from the substratum. A similar separation was observed beneath cells in vitro when viewed in life with interference-reflexion optics (IRM). A few focal contacts (adhesion plaques) were also seen with IRM and @entity1579 of cells in vitro, but were not seen with @entity1579 of cells in situ. Submarginal as well as marginal basal cells of the advancing sheet adhere and spread on the substratum in both situations, whereas cells of the outer layer are passive. Hence, the overall pattern of migration of these cells is similar in vitro and in situ; the differences in rates of movement may be explained in part by the different degree of @entity2701 in the epithelium under the 2 conditions.

title: Locomotion and cell-substratum contacts of XXXX epidermal cells in vitro and in situ.

entities_list: @entity1579 :: ('MESH:D017096', 'Disease') :: ['transmission electron microscopy', 'TEM']

entities_list: @entity71610 :: ('MESH:C537024', 'Disease') :: ['protruded lamellipodia']

answer: @entity1238 :: (8355,Species) :: ['Xenopus']


abstract: The only established role for complement in mediating immunologic @entity8 involves elaboration of leukochemotactic factors and neutrophil-dependent @entity8 . In the passive @entity8157 (PHN) model of experimental @entity8 , @entity35 injected with sheep antibody to @entity35 proximal tubular brush border antigen (Fx1A) form subepithelial deposits of sheep IgG and @entity35 complement (C3), and develop heavy @entity644 after 5 d without glomerular inflammatory changes. To study the role of complement in mediating @entity644 in PHN, 16 @entity35 were treated daily with cobra venom factor from before antibody injection to maintain C3 levels at < 10% of pretreatment values and compared to 16 untreated controls. @entity644 at 5 d was abolished in C3-depleted @entity35 (4 +/- 1, controls 70 +/- 15 mg/d, P < 0.001), although renal deposition of 125I-labeled antibody ws the same in both groups (188 +/- 35 vs. 191 +/- 22 microgram IgG/2 kidneys, P > 0.5). Nephritogenic doses of both the noncomplement-fixing F(ab')2 portion and the gamma 2 subclass of anti-Fx1A IgG produced subepithelial deposits of immunoglobulin without C3, but @entity644 did not occur despite glomerular deposition of up to 70 microgram/2 kidneys of gamma 2. However, glomerular deposition of as little as 60 microgram of gamma 1 produced C3 fixation in vivo and heavy @entity644 . No neutrophil exudate could be detected histologically in PHN from the time of antibody injection through development of @entity644 . @entity644 in five PHN @entity35 depleted of neutrophils to < 200/mm3 with antineutrophil serum was not reduced compared to six controls with normal neutrophil counts (34 +/- 9.6 vs. 25 +/- 10.4 mg/d, P > 0.5). These results demonstrate that @entity644 in the PHN model of @entity8 is complement-dependent and strongly suggest a neutrophil-independent mechanism. Thus a new role for the complement system in mediating immunologic @entity8 is identified.

title: A new role for complement in experimental XXXX in @entity35 .

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria', 'Proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['membranous nephropathy', 'renal disease', 'glomerular injury']

entities_list: @entity8157 :: ('MESH:D015433', 'Disease') :: ['Heymann nephritis']

answer: @entity8 :: (MESH:D007674,Disease) :: ['membranous nephropathy']


abstract: The only established role for complement in mediating immunologic @entity8 involves elaboration of leukochemotactic factors and neutrophil-dependent @entity8 . In the passive @entity8157 (PHN) model of experimental @entity8 , @entity35 injected with sheep antibody to @entity35 proximal tubular brush border antigen (Fx1A) form subepithelial deposits of sheep IgG and @entity35 complement (C3), and develop heavy @entity644 after 5 d without glomerular inflammatory changes. To study the role of complement in mediating @entity644 in PHN, 16 @entity35 were treated daily with cobra venom factor from before antibody injection to maintain C3 levels at < 10% of pretreatment values and compared to 16 untreated controls. @entity644 at 5 d was abolished in C3-depleted @entity35 (4 +/- 1, controls 70 +/- 15 mg/d, P < 0.001), although renal deposition of 125I-labeled antibody ws the same in both groups (188 +/- 35 vs. 191 +/- 22 microgram IgG/2 kidneys, P > 0.5). Nephritogenic doses of both the noncomplement-fixing F(ab')2 portion and the gamma 2 subclass of anti-Fx1A IgG produced subepithelial deposits of immunoglobulin without C3, but @entity644 did not occur despite glomerular deposition of up to 70 microgram/2 kidneys of gamma 2. However, glomerular deposition of as little as 60 microgram of gamma 1 produced C3 fixation in vivo and heavy @entity644 . No neutrophil exudate could be detected histologically in PHN from the time of antibody injection through development of @entity644 . @entity644 in five PHN @entity35 depleted of neutrophils to < 200/mm3 with antineutrophil serum was not reduced compared to six controls with normal neutrophil counts (34 +/- 9.6 vs. 25 +/- 10.4 mg/d, P > 0.5). These results demonstrate that @entity644 in the PHN model of @entity8 is complement-dependent and strongly suggest a neutrophil-independent mechanism. Thus a new role for the complement system in mediating immunologic @entity8 is identified.

title: A new role for complement in experimental @entity8 in XXXX .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: OBJECTIVES: Re-expansion @entity4 (RPO) sometimes occurs after minimally invasive cardiac surgery (MICS) with single-lung ventilation. However, it has not been widely recognized as a serious complication. The aim of this study is to evaluate the occurrence rate and risk factors of RPO. METHODS: A total of 381 consecutive @entity1 who underwent MICS with right mini-thoracotomy from March 2005 to October 2013 were retrospectively reviewed. RESULTS: RPO was observed in 8 (2.1%) @entity1 . In the preoperative data, greater percentages of preoperative use of @entity134 or immunosuppressant were found in @entity1 with RPO (25% [2/8] vs 1% [4/373]; P = 0.0056). In the operative data, significantly longer operation, cardiopulmonary bypass (CPB) and aortic cross-clamping (ACC) times as well as greater percentages of second CPB run were found in @entity1 with RPO (388    80 vs 272    61 min; P < 0.0002, 253    79 vs 158    50 min; P = 0.0009, 162    65 vs 108    38 min; P = 0.020 and 38% [3/8] vs 1.3% [5/373]; P < 0.0003). The overall 30-day mortality rate was 0.8% (3/381) and the 30-day mortality rate of @entity1 with RPO was 12.5% (1/8). Significantly prolonged initial ventilation time, intensive care unit and postoperative hospital stay were observed in @entity1 with RPO (P = 0.0022, <0.0001 and 0.0003, respectively). Multivariate logistic analysis detected preoperative use of @entity134 or immunosuppressant and prolonged ACC time (>= 156 min) as independent risk factors for RPO after MICS (odds ratio [OR]: 87.6 [95% confidence interval, CI: 4.1-2463.8]; P = 0.006 and OR: 36.0 [95% CI: 4.8-731.4]; P < 0.001). CONCLUSIONS: RPO should be recognized as one of the most serious complications after MICS with right mini-thoracotomy. More accurate risk factors of prolonged lung malperfusion and @entity134 use on RPO after MICS should be investigated.

title: Re-expansion XXXX after minimally invasive cardiac surgery with right mini-thoracotomy   .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['pulmonary oedema']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

answer: @entity4 :: (MESH:D004487,Disease) :: ['pulmonary oedema']


abstract: Histochemical analyses @entity172 (ER) and @entity1420 ( @entity7273 ) receptors in @entity0 were statistically correlated with results of dextran-coated charcoal (DDC) and @entity969 gradient assays. Correlated for ER was 91% of 363 cases, and for @entity7273 88% of 255 specimens. @entity0 ER/ @entity7273 positivity by histochemistry correlated with a favorable clinical response to endocrine therapies in 72% of 25 cases, while ER/ @entity7273 negativity correlated with a lack of response in 96% of 22 cases with @entity5 . Nuclear ER/ @entity7273 correlated with a poor response to therapy in 8 of 12 @entity1 . An in vitro technique to detect nuclear translocation of ER revealed two groups of ER positive cases, with 11 of 17 exhibiting translocation and 6 not displaying translocation. In @entity263 , 72% of 65 @entity1 were positive for ER and/or @entity342 receptor. Comparison of specimens obtained without and with electrocautery revealed a preponderance of nuclear binding in the latter, suggesting heat-induced nuclear translocation of receptor. @entity19097 , a naturally fluorescent, entirely unaltered @entity172 was also used for histochemical detection of ER. Results correlated with ER by DCC in 87% of 61 @entity0 . @entity19097 was additionally used to visually observe receptor and nuclear translocation of ER in intact whole cells in culture.

title: Histochemical analyses of steroid hormone receptors in XXXX .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity19097 :: ('MESH:D003375', 'Chemical') :: ['Coumestrol', 'coumestrol']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic carcinoma']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancers', 'breast cancer']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Stage IV disease']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast and prostatic carcinoma']


abstract: BACKGROUND: The objective of the study was to explore the expression features of serum miR-338-5p and soluble @entity8410 (sBAFF) in renal transplant recipients. METHODS: Follow-up renal transplant recipients (n  = 49) were enrolled in this study (male/female: 38/11). Healthy volunteers were controlled; 2  mL of peripheral blood from each subject was collected. Total RNA was extracted from serum by use of the miRNeasy Serum/Plasma Kit (QIAGEN), and miR-338-5p was amplified by means of quantitative real-time reverse transcriptase-polymerase chain reaction. sBAFF was detected by means of enzyme-linked immunoassay. LABScreen Mix ( @entity71611 ) (One Lambda) was used to test the level of anti-human leukocyte antigen (HLA) I antibody (Ab), anti-HLA II Ab, and anti-major histocompatibility complex class I chain-related A ( @entity1531 ) Ab. All data are shown as mean    SD and were analyzed by use of SPSS software 17.0. RESULTS: Compared with healthy volunteers, serum miR-338-5p in recipients was statistically downregulated (2.79    2.5 versus 0.09    0.12, P  < .001); sBAFF in recipients was significantly upregulated (1321    950  pg/mL versus 534    327  pg/mL, P  < .01); serum anti-HLAII Ab, anti- @entity1531 Ab, and anti-HLA+ @entity1531 Abs all statistically increased in recipients (P  < .05). Spearman correlation analysis showed that miR-338-5p was significantly negatively correlated with sBAFF (r  =  -0.51, P  < .001) and anti-HLA II antibody with mean fluorescence intensity value >1000 (r  =  -0.322, P  < .05). Analysis results also suggested that sBAFF was significantly negatively correlated with anti- @entity1531 Ab, with mean fluorescence intensity value >1000 (r  =  -0.579, P  < .05). CONCLUSIONS: miR-338-5p is closely correlated with the procedure of renal allograft antibody-mediated rejection.

title: Serum miR-338-5p, Soluble XXXX , Allo-Antibodies, and Renal Transplantation.

entities_list: @entity8410 :: ('10673', 'Gene') :: ['B-cell-activating factor']

answer: @entity8410 :: (10673,Gene) :: ['B-Cell-Activating Factor']


abstract: The mechanisms responsible for the development of a @entity281 (most commonly due to staphylococci) in the vicinity of an implanted foreign body have been studied recently by several investigators. Thus, we have been able to demonstrate that the phagocytic function of residential polymorphonuclear leukocytes (PMN) is deficient in the presence of a foreign body. Others have shown that in the presence of foreign surfaces, microorganisms produce extracellular amorphous material, the pathogenic role of which is still to be defined. In the present study we use a novel assay system to demonstrate that @entity794 Wood 46, after attachment to polymethylmethacrylate ( @entity4625 ), shows increased resistance to the phagocytic-bactericidal action of normal PMN. The first step of this assay involves the reproducible attachment of @entity665 -labeled bacteria to @entity4625 cover slips. During the second step, attached bacteria were exposed to @entity840 peritoneal exudate PMN. In the third and final step, attached @entity794 cells were removed from the cover slips using a procedure harmless to the bacteria. The extent of bacterial detachment was estimated by radioactive counts and their viability by standard colony counts. Whereas bacteria that were attached artificially and rapidly by centrifugation and immediately exposed to PMN were killed in the phagocytic assay, bacteria adhering spontaneously to the cover slips for a prolonged period of time were more resistant to the killing action of the phagocytes. The spontaneous adherence of @entity794 to @entity4625 renders it poorly susceptible to the killing action of PMN.

title: Attachment of XXXX to polymethylmethacrylate increases its resistance to phagocytosis in @entity281 .

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus']

entities_list: @entity665 :: ('CHEBI:53526', 'Chemical') :: ['[3H]thymidine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['pyogenic infection']

answer: @entity794 :: (1280,Species) :: ['Staphylococcus aureus']


abstract: The mechanisms responsible for the development of a @entity281 (most commonly due to staphylococci) in the vicinity of an implanted foreign body have been studied recently by several investigators. Thus, we have been able to demonstrate that the phagocytic function of residential polymorphonuclear leukocytes (PMN) is deficient in the presence of a foreign body. Others have shown that in the presence of foreign surfaces, microorganisms produce extracellular amorphous material, the pathogenic role of which is still to be defined. In the present study we use a novel assay system to demonstrate that @entity794 Wood 46, after attachment to polymethylmethacrylate ( @entity4625 ), shows increased resistance to the phagocytic-bactericidal action of normal PMN. The first step of this assay involves the reproducible attachment of @entity665 -labeled bacteria to @entity4625 cover slips. During the second step, attached bacteria were exposed to @entity840 peritoneal exudate PMN. In the third and final step, attached @entity794 cells were removed from the cover slips using a procedure harmless to the bacteria. The extent of bacterial detachment was estimated by radioactive counts and their viability by standard colony counts. Whereas bacteria that were attached artificially and rapidly by centrifugation and immediately exposed to PMN were killed in the phagocytic assay, bacteria adhering spontaneously to the cover slips for a prolonged period of time were more resistant to the killing action of the phagocytes. The spontaneous adherence of @entity794 to @entity4625 renders it poorly susceptible to the killing action of PMN.

title: Attachment of @entity794 to polymethylmethacrylate increases its resistance to phagocytosis in XXXX .

answer: @entity281 :: (MESH:D007239,Disease) :: ['foreign body infection']


abstract: The charts of 36 @entity1 , 27 males and 9 females, with @entity5572 diagnosed at the Hadassah University Hospital between 1967-1977 were reviewed. The @entity1 ranged in age from two months to 80 years and 25 @entity1 (69%) were older than 40 years. The diagnosis was initially suggested by liver scan in 18 @entity1 (50%), and was first made at autopsy in six (17%). The time-lapse between the onset of illness and diagnosis ranged from one day to 13 months, with a bimodal distribution. Large solitary abscesses were diagnosed later than small multiple abscesses. Ten @entity1 (28%) were admitted with fever as the only sign of illness; specific signs and laboratory evidence of liver involvement often occurred late in the course of the disease. In 15 @entity1 (42%), the etiology was regarded as amebic. In @entity1 with pyogenic abscesses, the most commonly isolated organisms belonged to the normal bowel flora and @entity253 was present in 62% (13/21) of these @entity1 . The overall mortality rate was 31%. This survey stresses the need for an increased awareness of the subtle presentation of @entity5572 .

title: XXXX at the Hadassah University during years 1967-77.

entities_list: @entity253 :: ('MESH:D001660', 'Disease') :: ['biliary tract disease']

entities_list: @entity5572 :: ('MESH:D008100', 'Disease') :: ['liver abscess']

answer: @entity5572 :: (MESH:D008100,Disease) :: ['Liver abscess']


abstract: OBJECTIVE: To calculate dose delivered to the lumbosacral plexus (LSP) with cervical brachytherapy using 3-dimensional imaging, and to compare this with the position of the tandem in the pelvis using bony landmarks. We also report long-term LSP @entity137 outcomes. METHODS AND MATERIALS: Treatment planning images from 55 @entity1 treated with tandem and ring brachytherapy from October 2009 through November 2012 were reviewed. The LSP was contoured on planning computed tomographic scans to calculate dose received.Lumbosacral plexus dose was studied as a function of tandem distance from the sacrum and pubic symphysis (STratio) measured on digitally reconstructed radiographs. @entity1 and implant characteristics were included as covariates on LSP dose. Clinical follow up on LSP @entity137 was recorded. RESULTS: @entity1 were prescribed 550 to 700 cGy using computed tomography-based imaged-guided brachytherapy for 4 to 5 fractions. The maximum dose to 2 cc (D2cc) of LSP ranged from 44 to 287 cGy per implant. The median D2cc was 118 cGy, corresponding to 18% of prescription dose. @entity1 with an STratio less than 0.33 (closer to the sacrum) and at least 0.33 had median LSP doses of 138 and 98 cGy, respectively. Lumbosacral plexus dose did not change significantly with body mass index, uterus position, or @entity5 stage. Two @entity1 reported symptoms of @entity1897 , with a median follow-up of 14.7 months. CONCLUSIONS: The mean D2cc per fraction to the LSP is roughly 20% of the prescribed high dose-rate and varies with the position of the tandem from the sacrum. The dose threshold for radiation-induced @entity16 of the LSP remains undefined.

title: Dose Delivered to the Lumbosacral Plexus From High-Dose-Rate Brachytherapy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cervical Cancer']


abstract: AIMS AND BACKGROUND: The main objective of this study is to evaluate outcomes of bladder preservation treatment for @entity1 with @entity150 . METHODS AND STUDY DESIGN: 38 @entity1 with histologically proven @entity150 treated at our department between January 2008 and December 2013 were analyzed retrospectively. Age, gender, pathology, stage, 3-year overall survival, 3-year disease-free survival, radiotherapy (RT) dose, genitourinary and gastrointestinal @entity137 scores and response evaluation of the @entity1 were recorded. 3-year overall survival and 3-year disease-free survivals were calculated by Kaplan-Meier method along with the analysis of gender, pathology, stage and therapy response of the study group. RESULTS: 33 @entity1 (86.8%) were managed with concomitant chemoradiotherapy whereas 5 @entity1 (13.2%) received only radiation therapy due to @entity8 . 6 (15.8%) out of 38 @entity1 had partial response (PR) and remaining 32 (84.2%) @entity1 experienced complete response (CR). The PR group underwent salvage cystectomy and CR group had been followed-up after radical radiotherapy. Mean age of the group was 70.9 (range 45-90) years. 26 of all @entity1 were male (68.4%) and 12 were female (31.6%). Mean follow-up time after completion of radiotherapy was 24.7 months (range 12-40). Mean RT dose was 64 Gy (range 60-66). 3-year overall survival was 64% and 3-year disease free survival was 73%. CONCLUSIONS: Bladder preserving approach is an alternative definitive therapy solution to radical cystectomy in the treatment of @entity150 with less morbidity, preserved natural bladder, and high quality of life.

title: Outcomes of trimodality approach in the management of T2N0M0 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal insufficency and comorbid diseases']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['muscle-invasive bladder cancer']

answer: @entity150 :: (MESH:D001749,Disease) :: ['bladder cancer']


abstract: UNASSIGNED: @entity130 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity158 is typically treated with opioids such as @entity3575 , @entity1286 , and @entity284 . Side effects of opioids include @entity1576 , @entity308 , decrease in motor and cognitive function, as well as the development of @entity1931 , tolerance and @entity734 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity158 in wounded combat service members. @entity1022 ( @entity4524 ) is a selective voltage-gated @entity1372 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity5 -related @entity158 has been completed and phase 3 clinical trials on chemotherapy-induced @entity9 are planned. It has also been shown in @entity19 to inhibit the development of chemotherapy-induced @entity9 . @entity4524 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity1 at therapeutic doses. The antinociceptive effects of @entity4524 are thought to be due to inhibition of @entity4024 ion influx required for initiation and conduction of nociceptive impulses. One @entity4524 sensitive @entity1372 channel, @entity14864 , has been shown to be essential in lowering the @entity158 threshold after @entity130 . To date, the analgesic effect of @entity4524 has not been tested in burn-associated @entity158 . Male @entity35 were subjected to a full thickness @entity130 on the right hind paw. @entity4524 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity130 and continued through 7 days post @entity130 . Thermal @entity1931 and mechanical @entity1931 were assessed 60 and 120min post injection on each day of @entity4524 treatment. @entity4524 significantly reduced thermal @entity1931 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity1931 . These results suggest that systemic @entity4524 may be an effective, rapidly acting analgesic for battlefield @entity130 and has the potential for replacing or reducing the need for opioid analgesics.

title: XXXX suppresses thermal @entity1931 and mechanical @entity1931 in a @entity35 full thickness @entity130 pain model.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['cardiac depression']

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia', 'allodynia']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1022 :: ('MESH:D013779', 'Chemical') :: ['Tetrodotoxin']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory depression']

entities_list: @entity284 :: ('MESH:D008691', 'Chemical') :: ['methadone']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['heat pain', 'pain']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['burn injuries', 'Burn injuries', 'thermal injury']

answer: @entity1022 :: (MESH:D013779,Chemical) :: ['Tetrodotoxin']


abstract: UNASSIGNED: @entity130 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity158 is typically treated with opioids such as @entity3575 , @entity1286 , and @entity284 . Side effects of opioids include @entity1576 , @entity308 , decrease in motor and cognitive function, as well as the development of @entity1931 , tolerance and @entity734 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity158 in wounded combat service members. @entity1022 ( @entity4524 ) is a selective voltage-gated @entity1372 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity5 -related @entity158 has been completed and phase 3 clinical trials on chemotherapy-induced @entity9 are planned. It has also been shown in @entity19 to inhibit the development of chemotherapy-induced @entity9 . @entity4524 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity1 at therapeutic doses. The antinociceptive effects of @entity4524 are thought to be due to inhibition of @entity4024 ion influx required for initiation and conduction of nociceptive impulses. One @entity4524 sensitive @entity1372 channel, @entity14864 , has been shown to be essential in lowering the @entity158 threshold after @entity130 . To date, the analgesic effect of @entity4524 has not been tested in burn-associated @entity158 . Male @entity35 were subjected to a full thickness @entity130 on the right hind paw. @entity4524 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity130 and continued through 7 days post @entity130 . Thermal @entity1931 and mechanical @entity1931 were assessed 60 and 120min post injection on each day of @entity4524 treatment. @entity4524 significantly reduced thermal @entity1931 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity1931 . These results suggest that systemic @entity4524 may be an effective, rapidly acting analgesic for battlefield @entity130 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity1022 suppresses thermal XXXX and mechanical @entity1931 in a @entity35 full thickness @entity130 pain model.

answer: @entity1931 :: (MESH:D006930,Disease) :: ['hyperalgesia']


abstract: UNASSIGNED: @entity130 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity158 is typically treated with opioids such as @entity3575 , @entity1286 , and @entity284 . Side effects of opioids include @entity1576 , @entity308 , decrease in motor and cognitive function, as well as the development of @entity1931 , tolerance and @entity734 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity158 in wounded combat service members. @entity1022 ( @entity4524 ) is a selective voltage-gated @entity1372 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity5 -related @entity158 has been completed and phase 3 clinical trials on chemotherapy-induced @entity9 are planned. It has also been shown in @entity19 to inhibit the development of chemotherapy-induced @entity9 . @entity4524 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity1 at therapeutic doses. The antinociceptive effects of @entity4524 are thought to be due to inhibition of @entity4024 ion influx required for initiation and conduction of nociceptive impulses. One @entity4524 sensitive @entity1372 channel, @entity14864 , has been shown to be essential in lowering the @entity158 threshold after @entity130 . To date, the analgesic effect of @entity4524 has not been tested in burn-associated @entity158 . Male @entity35 were subjected to a full thickness @entity130 on the right hind paw. @entity4524 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity130 and continued through 7 days post @entity130 . Thermal @entity1931 and mechanical @entity1931 were assessed 60 and 120min post injection on each day of @entity4524 treatment. @entity4524 significantly reduced thermal @entity1931 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity1931 . These results suggest that systemic @entity4524 may be an effective, rapidly acting analgesic for battlefield @entity130 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity1022 suppresses thermal @entity1931 and mechanical XXXX in a @entity35 full thickness @entity130 pain model.

answer: @entity1931 :: (MESH:D006930,Disease) :: ['allodynia']


abstract: UNASSIGNED: @entity130 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity158 is typically treated with opioids such as @entity3575 , @entity1286 , and @entity284 . Side effects of opioids include @entity1576 , @entity308 , decrease in motor and cognitive function, as well as the development of @entity1931 , tolerance and @entity734 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity158 in wounded combat service members. @entity1022 ( @entity4524 ) is a selective voltage-gated @entity1372 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity5 -related @entity158 has been completed and phase 3 clinical trials on chemotherapy-induced @entity9 are planned. It has also been shown in @entity19 to inhibit the development of chemotherapy-induced @entity9 . @entity4524 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity1 at therapeutic doses. The antinociceptive effects of @entity4524 are thought to be due to inhibition of @entity4024 ion influx required for initiation and conduction of nociceptive impulses. One @entity4524 sensitive @entity1372 channel, @entity14864 , has been shown to be essential in lowering the @entity158 threshold after @entity130 . To date, the analgesic effect of @entity4524 has not been tested in burn-associated @entity158 . Male @entity35 were subjected to a full thickness @entity130 on the right hind paw. @entity4524 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity130 and continued through 7 days post @entity130 . Thermal @entity1931 and mechanical @entity1931 were assessed 60 and 120min post injection on each day of @entity4524 treatment. @entity4524 significantly reduced thermal @entity1931 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity1931 . These results suggest that systemic @entity4524 may be an effective, rapidly acting analgesic for battlefield @entity130 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity1022 suppresses thermal @entity1931 and mechanical @entity1931 in a @entity35 full thickness XXXX pain model.

answer: @entity130 :: (MESH:D014947,Disease) :: ['thermal injury']


abstract: UNASSIGNED: @entity130 have been identified as the primary cause of injury in 5% of U.S. military personnel evacuated from Operations Iraqi Freedom and Enduring Freedom. Severe burn-associated @entity158 is typically treated with opioids such as @entity3575 , @entity1286 , and @entity284 . Side effects of opioids include @entity1576 , @entity308 , decrease in motor and cognitive function, as well as the development of @entity1931 , tolerance and @entity734 . These effects have led us to search for novel analgesics for the treatment of burn-associated @entity158 in wounded combat service members. @entity1022 ( @entity4524 ) is a selective voltage-gated @entity1372 channel blocker currently in clinical trials as an analgesic. A phase 3 clinical trial for @entity5 -related @entity158 has been completed and phase 3 clinical trials on chemotherapy-induced @entity9 are planned. It has also been shown in @entity19 to inhibit the development of chemotherapy-induced @entity9 . @entity4524 was originally identified as a neurotoxin in marine animals but has now been shown to be safe in @entity1 at therapeutic doses. The antinociceptive effects of @entity4524 are thought to be due to inhibition of @entity4024 ion influx required for initiation and conduction of nociceptive impulses. One @entity4524 sensitive @entity1372 channel, @entity14864 , has been shown to be essential in lowering the @entity158 threshold after @entity130 . To date, the analgesic effect of @entity4524 has not been tested in burn-associated @entity158 . Male @entity35 were subjected to a full thickness @entity130 on the right hind paw. @entity4524 (8 g/kg) was administered once a day systemically by subcutaneous injection beginning 3 days post @entity130 and continued through 7 days post @entity130 . Thermal @entity1931 and mechanical @entity1931 were assessed 60 and 120min post injection on each day of @entity4524 treatment. @entity4524 significantly reduced thermal @entity1931 at all days tested and had a less robust, but statistically significant suppressive effect on mechanical @entity1931 . These results suggest that systemic @entity4524 may be an effective, rapidly acting analgesic for battlefield @entity130 and has the potential for replacing or reducing the need for opioid analgesics.

title: @entity1022 suppresses thermal @entity1931 and mechanical @entity1931 in a XXXX full thickness @entity130 pain model.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: UNASSIGNED: Current @entity101 guidelines advocate strategies encouraging healthy lifestyle behaviours. So far, there is a paucity of studies for the efficacy of such multifaceted programmes. The aim of this study is to investigate the efficacy of an 8-week health-promotion programme for lowering blood pressure (BP) in @entity1556 and @entity101 @entity1 in the community. This was a quasi-experimental study using wait-list controls of 548 @entity1 . The intervention group was administered with an 8-week health-promotion intervention. Measurements included home BP, smoking, body mass index (BMI), perceived stress, @entity308 , @entity148 and Health Locus of Control. After adjusting for confounders, the intervention group had a significant @entity551 ( @entity13519 ; mean -2.62   mm   Hg, 95% confidence interval (CI): -1.29 to -3.96) and @entity551 ( @entity551 ; mean -1.0, 95% CI: -0.93 to -1.9) compared with controls. In all, 14.9% of @entity1 in the intervention group had >10   mm   @entity5332 reduction in @entity13519 vs 4.4% in the control group (P<0.001, numbers needed to treat (NNT)=10). With regards to @entity551 , 21.7% of @entity1 in the intervention group had >5   mm   Hg reduction vs 12.5% in the control group (P=0.01, NNT=11). In terms of effect size, moderate-to-large improvements of BMI, perceived stress, @entity148 , @entity308 , external and chance Health Locus of Control were recorded. Changes in @entity13519 and @entity551 were attributed to BMI and depressive symptom reductions, respectively. Comprehensive non-pharmaceutical programmes for BP management are strongly encouraged. Their long-term benefits on @entity65 and mortality remain to be established by future research.Journal of @entity1 @entity101 advance online publication, 1 October 2015; doi:10.1038/jhh.2015.99.

title: A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for XXXX and @entity101 @entity1 : a quasi-experimental study in Greece.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Human']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['DBP', 'reduction in both systolic BP', 'diastolic BP']

entities_list: @entity1556 :: ('MESH:D058246', 'Disease') :: ['prehypertensive']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular morbidity']

answer: @entity1556 :: (MESH:D058246,Disease) :: ['prehypertensive']


abstract: UNASSIGNED: Current @entity101 guidelines advocate strategies encouraging healthy lifestyle behaviours. So far, there is a paucity of studies for the efficacy of such multifaceted programmes. The aim of this study is to investigate the efficacy of an 8-week health-promotion programme for lowering blood pressure (BP) in @entity1556 and @entity101 @entity1 in the community. This was a quasi-experimental study using wait-list controls of 548 @entity1 . The intervention group was administered with an 8-week health-promotion intervention. Measurements included home BP, smoking, body mass index (BMI), perceived stress, @entity308 , @entity148 and Health Locus of Control. After adjusting for confounders, the intervention group had a significant @entity551 ( @entity13519 ; mean -2.62   mm   Hg, 95% confidence interval (CI): -1.29 to -3.96) and @entity551 ( @entity551 ; mean -1.0, 95% CI: -0.93 to -1.9) compared with controls. In all, 14.9% of @entity1 in the intervention group had >10   mm   @entity5332 reduction in @entity13519 vs 4.4% in the control group (P<0.001, numbers needed to treat (NNT)=10). With regards to @entity551 , 21.7% of @entity1 in the intervention group had >5   mm   Hg reduction vs 12.5% in the control group (P=0.01, NNT=11). In terms of effect size, moderate-to-large improvements of BMI, perceived stress, @entity148 , @entity308 , external and chance Health Locus of Control were recorded. Changes in @entity13519 and @entity551 were attributed to BMI and depressive symptom reductions, respectively. Comprehensive non-pharmaceutical programmes for BP management are strongly encouraged. Their long-term benefits on @entity65 and mortality remain to be established by future research.Journal of @entity1 @entity101 advance online publication, 1 October 2015; doi:10.1038/jhh.2015.99.

title: A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for @entity1556 and XXXX @entity1 : a quasi-experimental study in Greece.

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: UNASSIGNED: Current @entity101 guidelines advocate strategies encouraging healthy lifestyle behaviours. So far, there is a paucity of studies for the efficacy of such multifaceted programmes. The aim of this study is to investigate the efficacy of an 8-week health-promotion programme for lowering blood pressure (BP) in @entity1556 and @entity101 @entity1 in the community. This was a quasi-experimental study using wait-list controls of 548 @entity1 . The intervention group was administered with an 8-week health-promotion intervention. Measurements included home BP, smoking, body mass index (BMI), perceived stress, @entity308 , @entity148 and Health Locus of Control. After adjusting for confounders, the intervention group had a significant @entity551 ( @entity13519 ; mean -2.62   mm   Hg, 95% confidence interval (CI): -1.29 to -3.96) and @entity551 ( @entity551 ; mean -1.0, 95% CI: -0.93 to -1.9) compared with controls. In all, 14.9% of @entity1 in the intervention group had >10   mm   @entity5332 reduction in @entity13519 vs 4.4% in the control group (P<0.001, numbers needed to treat (NNT)=10). With regards to @entity551 , 21.7% of @entity1 in the intervention group had >5   mm   Hg reduction vs 12.5% in the control group (P=0.01, NNT=11). In terms of effect size, moderate-to-large improvements of BMI, perceived stress, @entity148 , @entity308 , external and chance Health Locus of Control were recorded. Changes in @entity13519 and @entity551 were attributed to BMI and depressive symptom reductions, respectively. Comprehensive non-pharmaceutical programmes for BP management are strongly encouraged. Their long-term benefits on @entity65 and mortality remain to be established by future research.Journal of @entity1 @entity101 advance online publication, 1 October 2015; doi:10.1038/jhh.2015.99.

title: A HEALth Promotion and STRESS Management Program (HEAL-STRESS study) for @entity1556 and @entity101 XXXX : a quasi-experimental study in Greece.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECT Structural spinal surgery yields improvement in @entity158 and disability for selected @entity1 with @entity612 , spondylolisthesis, or a herniated @entity1798 . A significant fraction of @entity1 exhibit persistent postoperative @entity9 (PPNP) despite technically appropriate intervention, and such @entity1 can benefit from @entity602 ( @entity602 ) to alleviate suffering. The complication profile of this therapy has not been systematically assessed and, thus, was the goal of this review. METHODS A comprehensive literature search was performed to identify prospective cohorts of @entity1 who had PPNP following structurally corrective lumbar spinal surgery and who underwent @entity602 device implantation. Data about study design, technique of @entity602 lead introduction, and complications encountered were collected and analyzed. Comparisons of complication incidence were performed between percutaneously and surgically implanted systems, with the level of significance set at 0.05. RESULTS Review of 11 studies involving 542 @entity1 formed the basis of this work: 2 randomized controlled trials and 9 prospective cohorts. Percutaneous implants were used in 4 studies and surgical implants were used in 4 studies; in the remainder, the types were undefined. Lead migration occurred in 12% of cases, @entity158 at the site of the implantable pulse generator occurred in 9% of cases, and wound-related complications occurred in 5% of cases; the latter 2 occurred more frequently among surgically implanted devices. CONCLUSIONS Spinal cord stimulation can provide for improved @entity158 and suffering and for decreased narcotic medication use among @entity1 with PPNP after lumbar spinal surgery. This study reviewed the prospective studies forming the evidence base for this therapy, to summarize the complications encountered and, thus, best inform @entity1 and clinicians considering its use. There is a significant rate of minor complications, many of which require further surgical intervention to manage, including lead migration or implant infection, although such complications do not directly threaten @entity1 life or function.

title: Complications related to the use of XXXX for managing persistent postoperative @entity9 after lumbar spinal surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity612 :: ('MESH:D013130', 'Disease') :: ['spinal stenosis']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['spinal cord stimulation', 'SCS']

entities_list: @entity1798 :: ('MESH:C535531', 'Disease') :: ['intervertebral disc']

answer: @entity602 :: (MESH:D013118,Disease) :: ['spinal cord stimulation']


abstract: OBJECT Structural spinal surgery yields improvement in @entity158 and disability for selected @entity1 with @entity612 , spondylolisthesis, or a herniated @entity1798 . A significant fraction of @entity1 exhibit persistent postoperative @entity9 (PPNP) despite technically appropriate intervention, and such @entity1 can benefit from @entity602 ( @entity602 ) to alleviate suffering. The complication profile of this therapy has not been systematically assessed and, thus, was the goal of this review. METHODS A comprehensive literature search was performed to identify prospective cohorts of @entity1 who had PPNP following structurally corrective lumbar spinal surgery and who underwent @entity602 device implantation. Data about study design, technique of @entity602 lead introduction, and complications encountered were collected and analyzed. Comparisons of complication incidence were performed between percutaneously and surgically implanted systems, with the level of significance set at 0.05. RESULTS Review of 11 studies involving 542 @entity1 formed the basis of this work: 2 randomized controlled trials and 9 prospective cohorts. Percutaneous implants were used in 4 studies and surgical implants were used in 4 studies; in the remainder, the types were undefined. Lead migration occurred in 12% of cases, @entity158 at the site of the implantable pulse generator occurred in 9% of cases, and wound-related complications occurred in 5% of cases; the latter 2 occurred more frequently among surgically implanted devices. CONCLUSIONS Spinal cord stimulation can provide for improved @entity158 and suffering and for decreased narcotic medication use among @entity1 with PPNP after lumbar spinal surgery. This study reviewed the prospective studies forming the evidence base for this therapy, to summarize the complications encountered and, thus, best inform @entity1 and clinicians considering its use. There is a significant rate of minor complications, many of which require further surgical intervention to manage, including lead migration or implant infection, although such complications do not directly threaten @entity1 life or function.

title: Complications related to the use of @entity602 for managing persistent postoperative XXXX after lumbar spinal surgery.

answer: @entity9 :: (MESH:D009437,Disease) :: ['neuropathic pain']


abstract: OBJECTIVE: Perioperative complications in @entity1 undergoing transcatheter @entity886 remain a major issue affecting outcome. Because preoperative risk adjustment remains challenging and a valid scoring system is missing, we sought to determine the incidence of peri- and postprocedural complications of transapical (TA) or transaortic (TAO) access to define the influence of specific complications on early safety, 30-day mortality, and 1-year survival. Furthermore, we aimed to develop a risk-stratification model to allow an estimation of the perioperative risk and the 1-year survival rate, based on the individual preoperative condition of each @entity1 . METHODS: We performed an outcome analysis of 230 consecutive @entity1 who underwent @entity886 via transapical or transaortic access between 2008 and 2012, with regard to Valve @entity4207 , including univariate and multivariable regression analysis, to develop a risk-stratification model. RESULTS: Thirty-day mortality was 12.7%. Estimated 1-year survival was 0.69 (95% confidence interval [CI], 0.631-0.757), and 3-year survival was 0.554 (95% CI, 0.474-0.634). Univariate logistic regression analysis revealed a significant influence on 30-day mortality in case of life-threatening @entity548 (16.1-fold), abdominal complications (8.5-fold), and @entity810 (3.2-fold). Pacemaker implantation (odds ratio, 1.55; 95% CI, 0.42-5.81; P  =  .512) was not a significant predictor. Concerning use of intraprocedural hemodynamic bridging therapy via cardiopulmonary bypass (CPB), Cox regression analysis revealed no significant survival difference after 1  year. A preoperative risk-stratification model for 1-year survival revealed that a logistic European System for Cardiac Operative Risk Evaluation score >20%, preoperative existing @entity453 , and prior @entity583 appeared to be significant predictors for diminished survival. CONCLUSIONS: Concerning intraprocedural complications, CPB support for hemodynamic stabilization is a safe treatment option. Therefore, the heart team approach with CPB standby represents a life-saving option. Attention should also be drawn to  specialized and individual postoperative care, because nonprocedure-specific complications clearly affect postoperative short- and long-term outcome. In addition, the risk-stratification model might facilitate preoperative decision making.

title: Focus on the surgical approach to transcatheter XXXX : Complications, outcome, and preoperative risk adjustment.

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve implantation']

entities_list: @entity4207 :: ('MESH:D007859', 'Disease') :: ['Academic Research Consortium II criteria']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity886 :: (MESH:C563178,Disease) :: ['aortic valve implantation']


abstract: PURPOSE: To evaluate risk factors for deterioration of lower urinary tract symptoms (LUTS) in elderly @entity1 in a community-based, prospective longitudinal cohort study. METHODS: In a suburban area in Korea, 1,514 subjects aged >= 45 years were randomly selected by systematic sampling. A total of 918 elderly subjects were enrolled in this in-depth clinical study in 2004. Of these, 547 @entity1 were followed up for 3 years and the data was analyzed in 2014. Standard questionnaires were administered face-to-face by trained interviewers. After excluding @entity1 , 224 male @entity1 with complete data including transrectal ultrasonography were included in the final analysis. LUTS were diagnosed using the International Prostate Symptom Score (IPSS) questionnaire. Symptom deterioration was defined as a score of >= 8 points during the 3-year follow-up period. RESULTS: LUTS prevalence increased to 13.1% and the mean IPSS increased by 2.6 points during the 3-year period. After adjusting for confounders, a smoking history of >= 50 pack-years was an independent risk factor for deterioration of LUTS and storage subsymptoms compared with no history of smoking (3.1 and 5.1 odds, respectively). Physical activity had a protective effect on voiding subsymptoms. However, high protein diet and @entity285 intake were not associated with LUTS deterioration. CONCLUSIONS: The LUTS prevalence among elderly @entity1 living in a suburban area increased to 13.1% and the IPSS increased by 2.6 points during the 3-year period. A history of heavy smoking, low physical activity, and high protein intake were associated with LUTS deterioration. However, there was no significant association between @entity285 intake and LUTS deterioration.

title: XXXX , Smoking, Physical Activity, Protein, and Lower Urinary Tract Symptoms: Prospective Longitudinal Cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

answer: @entity285 :: (D000431,Chemical) :: ['Alcohol']


abstract: BACKGROUND: Unplanned care interruption (UCI) challenges effective @entity645 treatment. We determined the frequency and risk factors for UCI in Nigeria. METHODS: We conducted a retrospective-cohort study of adults initiating antiretroviral therapy (ART) between January 2009 and December 2011. At censor, @entity1 were defined as in care, UCI, or inactive. Associations between baseline factors and UCI rates were quantified using Poisson regression. RESULTS: Among 2,496 @entity1 , 44 % remained in care, 35 % had >= 1 UCI, and 21 % became inactive. UCI rates were higher in the first year on ART (39/100PY), than the second (19/100PY), third (16/100PY), and fourth (14/100PY) years (p   <   0.001). In multivariate analysis, baseline @entity404   >   350/uL ( @entity12623 3.21, p   <   0.0001), being a student ( @entity12623 1.95, p   <   0.0001), and less education ( @entity12623 1.58, p   =   0.001) increased risk for UCI. Fifty-five percent of @entity1 with UCI and viral load data had @entity645 viral load   >   1,000 copies/ml upon return to care. DISCUSSION: UCI were observed in over one-third of @entity1 treated, and were most common in the first year on ART. High baseline @entity404 count at ART initiation was the greatest predictor of subsequent UCI. CONCLUSIONS: Interventions focused on the first year on ART are needed to improve continuity of @entity645 care.

title: High rates of unplanned interruptions from XXXX care early after antiretroviral therapy initiation in Nigeria.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity645 :: (57667,Species) :: ['HIV']


abstract: UNASSIGNED: @entity2690 resistance (IR) and @entity32 are associated with an increased risk of @entity65 and may contribute to @entity296 . The earliest sign of @entity296 is impaired left ventricular (LV) diastolic function, which may be evident in @entity28 @entity1 and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and @entity28 and to assess the relative individual contributions of adiposity, IR, and @entity32 to alterations in cardiac structure and function. We studied 35 OW (body mass index standard deviation score 2.0    0.8; non-IR n  = 19, IR n  = 16) and 34 non-OW youth (body mass index standard deviation score 0.1    0.7). LV diastolic function was reduced in OW youth compared with non-OW controls, as indicated by lower peak myocardial relaxation velocities (p <0.001) and greater filling pressures (p <0.001). OW youth also had greater LV mass index (p <0.001), left atrial volume index, and LV interventricular septal thickness (LV-IVS; both p  = 0.02). IR-OW youth had the highest LV filling pressures, LV-IVS, and relative wall thickness (all p <0.05). Homeostasis model of assessment- @entity2690 resistance and @entity1851 were negative determinants of peak myocardial relaxation velocity and positive predictors of filling pressure. @entity1254 was a negative determinant of LV-IVS, independent of @entity28 . In conclusion, OW youth with IR and @entity32 are more likely to have adverse changes to cardiovascular structure and function which may predispose to premature @entity65 in adulthood.

title: Relation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to XXXX Resistance and @entity32 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['obesity cardiomyopathy']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese (OW) youth', 'obese', 'obesity']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity2690 :: (3630,Gene) :: ['Insulin']


abstract: UNASSIGNED: @entity2690 resistance (IR) and @entity32 are associated with an increased risk of @entity65 and may contribute to @entity296 . The earliest sign of @entity296 is impaired left ventricular (LV) diastolic function, which may be evident in @entity28 @entity1 and adolescents. However, the precise metabolic basis of the impaired LV diastolic function remains unknown. The aims of this study were to evaluate cardiac structure and LV diastolic function by tissue Doppler imaging in overweight and @entity28 and to assess the relative individual contributions of adiposity, IR, and @entity32 to alterations in cardiac structure and function. We studied 35 OW (body mass index standard deviation score 2.0    0.8; non-IR n  = 19, IR n  = 16) and 34 non-OW youth (body mass index standard deviation score 0.1    0.7). LV diastolic function was reduced in OW youth compared with non-OW controls, as indicated by lower peak myocardial relaxation velocities (p <0.001) and greater filling pressures (p <0.001). OW youth also had greater LV mass index (p <0.001), left atrial volume index, and LV interventricular septal thickness (LV-IVS; both p  = 0.02). IR-OW youth had the highest LV filling pressures, LV-IVS, and relative wall thickness (all p <0.05). Homeostasis model of assessment- @entity2690 resistance and @entity1851 were negative determinants of peak myocardial relaxation velocity and positive predictors of filling pressure. @entity1254 was a negative determinant of LV-IVS, independent of @entity28 . In conclusion, OW youth with IR and @entity32 are more likely to have adverse changes to cardiovascular structure and function which may predispose to premature @entity65 in adulthood.

title: Relation of Reduced Preclinical Left Ventricular Diastolic Function and Cardiac Remodeling in Overweight Youth to @entity2690 Resistance and XXXX .

answer: @entity32 :: (MESH:D007249,Disease) :: ['Inflammation']


abstract: UNASSIGNED: Noroviruses are the main cause of severe @entity1800 , which results in estimated 200,000 @entity204 each year, primarily in @entity1 in the developing world. Genogroup II.4 (GII.4) strains are responsible for the majority of norovirus outbreaks. Enterovirus 71 (EV71), the leading causative agent of hand, foot @entity3137 , has recently been prevalent in Asia-Pacific regions, resulting in significant morbidity and mortality in young @entity1 . However, no vaccine is commercially available for either norovirus GII.4 or EV71. Recombinant virus-like particles (VLPs) derived from either GII.4 or EV71 have been shown to be promising monovalent vaccine candidates. In this study, we investigate the possibility to formulate a VLP-based bivalent vaccine for both norovirus GII.4 and EV71. The GII.4- and EV71-VLPs were produced in a baculovirus-insect cell expression system. A bivalent combination vaccine comprised of GII.4 and EV71 VLPs was formulated and compared with monovalent GII.4- and EV71-VLPs for their immunogenicity in @entity19 . We found that the bivalent vaccine elicited durable antibody responses toward both GII.4 and EV71, and the antibody titers were comparable to that induced by the monovalent vaccines, indicating there is no immunological interference between the two antigens in the combination vaccine. More significantly, the bivalent vaccine-immunized @entity19 sera could efficiently neutralize EV71 infection and block GII.4-VLP binding to mucin. Together, our results demonstrate that the experimental combination vaccine comprised of GII.4 and EV71-VLPs is able to induce a balanced protective antibody response, and therefore strongly support further preclinical and clinical development of such a bivalent VLP vaccine targeting both norovirus GII.4 and EV71.

title: A bivalent virus-like particle based vaccine induces a balanced antibody response against both enterovirus 71 and norovirus in XXXX .

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral gastroenteritis']

entities_list: @entity3137 :: ('MESH:D009059', 'Disease') :: ['and mouth disease']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: UNASSIGNED: @entity6 may be present at the time type 2 @entity6 is diagnosed, and initial screening encompassing an eye examination performed by an ophthalmologist or optometrist is therefore recommended. However, proper screening for @entity989 may be challenging in many parts of the world. We hypothesized that simple, commonly available @entity1 characteristics can be used to identify @entity1 at high risk for having @entity989 . We investigated data from multiple years extracted from the National Health and Nutrition Examination Survey which holds information about blood @entity413 and eye examinations. Individuals with hitherto undiagnosed @entity6 were classified according to the presence or absence of @entity989 . Linear classification was used to predict which @entity1 had @entity989 at the time of diagnosis. A total of 266 individuals with undiagnosed @entity6 were identified from the cohorts. Of these, 222 individuals had no sign of @entity989 , whereas 44 had mild or moderate @entity989 . Using information regarding HbA1c, BMI, waist circumference, age, systolic blood pressure, urinary albumin, and urinary @entity1011 , we were able to construct a model that predicts the presence of @entity989 with a positive predictive value of 22% and a negative predictive value of 99%. Only one true positive (1/44) with mild @entity989 was falsely classified. A classification model using readily available @entity1 information and routine biochemical measures can be used to identify @entity1 at high risk of having @entity989 at the time their @entity6 is diagnosed. The model may be used to identify high-risk @entity1 for @entity989 screening.

title: A classification model for predicting eye disease in newly diagnosed @entity1 with type 2 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'Diabetic retinopathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy', 'non-proliferative retinopathy']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: UNASSIGNED: @entity6 may be present at the time type 2 @entity6 is diagnosed, and initial screening encompassing an eye examination performed by an ophthalmologist or optometrist is therefore recommended. However, proper screening for @entity989 may be challenging in many parts of the world. We hypothesized that simple, commonly available @entity1 characteristics can be used to identify @entity1 at high risk for having @entity989 . We investigated data from multiple years extracted from the National Health and Nutrition Examination Survey which holds information about blood @entity413 and eye examinations. Individuals with hitherto undiagnosed @entity6 were classified according to the presence or absence of @entity989 . Linear classification was used to predict which @entity1 had @entity989 at the time of diagnosis. A total of 266 individuals with undiagnosed @entity6 were identified from the cohorts. Of these, 222 individuals had no sign of @entity989 , whereas 44 had mild or moderate @entity989 . Using information regarding HbA1c, BMI, waist circumference, age, systolic blood pressure, urinary albumin, and urinary @entity1011 , we were able to construct a model that predicts the presence of @entity989 with a positive predictive value of 22% and a negative predictive value of 99%. Only one true positive (1/44) with mild @entity989 was falsely classified. A classification model using readily available @entity1 information and routine biochemical measures can be used to identify @entity1 at high risk of having @entity989 at the time their @entity6 is diagnosed. The model may be used to identify high-risk @entity1 for @entity989 screening.

title: A classification model for predicting eye disease in newly diagnosed XXXX with type 2 @entity6 .

answer: @entity1 :: (9606,Species) :: ['people']


abstract: BACKGROUND: @entity882 is a frequent finding in critically ill @entity5 @entity1 for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of @entity548 in @entity5 @entity1 with hypoproliferative @entity882 in the intensive care unit (ICU). METHODS: A retrospective monocenter study over a 7-year period was conducted in a medical ICU. Adult @entity1 with @entity882 , and who received at least one platelet concentrate during their ICU stay, were included. RESULTS: 296 @entity1 were included and received a total of 904 platelet transfusions, for prophylactic indications in 300 (33.2  %) episodes, for securing an invasive procedure in 257 (28.4  %), and for treatment of minor to major @entity548 manifestations in 347 (38.4  %). Most prophylactic transfusions (80  %) were performed at platelet count thresholds below 10-20  *  10(9)/L. Platelet increments were generally low in all three indications, 10 (interquartile range 2-25), 11 (2-25), and 8 (0-21)  *  10(9)/L, respectively. A total of 97 major ICU-acquired @entity548 events occurred in 40 @entity1 . About half of those @entity548 episodes (54.7  %) occurred at platelet counts below 20  *  10(9)/L. However, neither low admission platelet count nor low nadir platelet counts were predictive of ICU-acquired @entity548 . The in-ICU mortality rate tended to be higher in @entity1 with severe ICU-acquired @entity548 events (50 vs. 36  %). CONCLUSIONS: Most prophylactic platelet transfusions were given using thresholds of 10-20  *  10(9)/L in critically ill @entity5 @entity1 . The individual risk of ICU-acquired severe @entity548 appears hardly predictable with the depth of @entity882 .

title: Platelet transfusions in @entity5 @entity1 with hypoproliferative XXXX in the intensive care unit.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'thrombocytopenic cancer']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['Thrombocytopenia', 'malignancies and hypoproliferative thrombocytopenia', 'thrombocytopenia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity882 :: (MESH:D013921,Disease) :: ['thrombocytopenia']


abstract: BACKGROUND: @entity882 is a frequent finding in critically ill @entity5 @entity1 for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of @entity548 in @entity5 @entity1 with hypoproliferative @entity882 in the intensive care unit (ICU). METHODS: A retrospective monocenter study over a 7-year period was conducted in a medical ICU. Adult @entity1 with @entity882 , and who received at least one platelet concentrate during their ICU stay, were included. RESULTS: 296 @entity1 were included and received a total of 904 platelet transfusions, for prophylactic indications in 300 (33.2  %) episodes, for securing an invasive procedure in 257 (28.4  %), and for treatment of minor to major @entity548 manifestations in 347 (38.4  %). Most prophylactic transfusions (80  %) were performed at platelet count thresholds below 10-20  *  10(9)/L. Platelet increments were generally low in all three indications, 10 (interquartile range 2-25), 11 (2-25), and 8 (0-21)  *  10(9)/L, respectively. A total of 97 major ICU-acquired @entity548 events occurred in 40 @entity1 . About half of those @entity548 episodes (54.7  %) occurred at platelet counts below 20  *  10(9)/L. However, neither low admission platelet count nor low nadir platelet counts were predictive of ICU-acquired @entity548 . The in-ICU mortality rate tended to be higher in @entity1 with severe ICU-acquired @entity548 events (50 vs. 36  %). CONCLUSIONS: Most prophylactic platelet transfusions were given using thresholds of 10-20  *  10(9)/L in critically ill @entity5 @entity1 . The individual risk of ICU-acquired severe @entity548 appears hardly predictable with the depth of @entity882 .

title: Platelet transfusions in XXXX @entity1 with hypoproliferative @entity882 in the intensive care unit.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND: @entity882 is a frequent finding in critically ill @entity5 @entity1 for whom indications of platelet transfusions are unclear. We herein addressed the current practices in platelet transfusion and the risk of @entity548 in @entity5 @entity1 with hypoproliferative @entity882 in the intensive care unit (ICU). METHODS: A retrospective monocenter study over a 7-year period was conducted in a medical ICU. Adult @entity1 with @entity882 , and who received at least one platelet concentrate during their ICU stay, were included. RESULTS: 296 @entity1 were included and received a total of 904 platelet transfusions, for prophylactic indications in 300 (33.2  %) episodes, for securing an invasive procedure in 257 (28.4  %), and for treatment of minor to major @entity548 manifestations in 347 (38.4  %). Most prophylactic transfusions (80  %) were performed at platelet count thresholds below 10-20  *  10(9)/L. Platelet increments were generally low in all three indications, 10 (interquartile range 2-25), 11 (2-25), and 8 (0-21)  *  10(9)/L, respectively. A total of 97 major ICU-acquired @entity548 events occurred in 40 @entity1 . About half of those @entity548 episodes (54.7  %) occurred at platelet counts below 20  *  10(9)/L. However, neither low admission platelet count nor low nadir platelet counts were predictive of ICU-acquired @entity548 . The in-ICU mortality rate tended to be higher in @entity1 with severe ICU-acquired @entity548 events (50 vs. 36  %). CONCLUSIONS: Most prophylactic platelet transfusions were given using thresholds of 10-20  *  10(9)/L in critically ill @entity5 @entity1 . The individual risk of ICU-acquired severe @entity548 appears hardly predictable with the depth of @entity882 .

title: Platelet transfusions in @entity5 XXXX with hypoproliferative @entity882 in the intensive care unit.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: @entity3853 is a food-borne @entity4801 induced by the @entity2199 @entity23699 , and has been recognized as the main cause leading to @entity1 @entity693 . @entity1 usually acquire @entity281 by digestion of infected Pomacea canaliculata and Achatina fulica, the most predominant intermediate hosts found in China. This meta-analysis was aimed to assess the prevalence of A. cantonensis @entity281 among these two snails in China in the past 10  years. Data were systematically collected in electronic databases such as PubMed, Web of Science, ScienceDirect, CNKI, SinoMed, VIP, CSCD, and Wanfang from 2005 to 2015. Thirty-eight studies with a total of 41,299 P. canaliculata and 21,138 Ac. fulica were included in the present study. The overall @entity281 rate of A. cantonensis in China was estimated to be 7.6  % (95  % confidential interval (CI)   =   0.063 to 0.090) in P. canaliculata and 21.5  % in Ac. fulica (95  % CI   =   0.184 to 0.245), respectively. No significant difference was observed in prevalence rates among publication year and sample size for both snails. Also, it was found that the prevalence in Ac. fulica is significantly higher than that in P. canaliculata (odds ratio (OR)   =   3.946, 95  % CI   =   3.070 to 5.073). The present study reveals that snail @entity281 with A. cantonensis is clearly prevalent in China. Further studies are required to improve strategies for control of @entity281 , particularly those of Ac. fulica, and to detect further factors and conditions such as geographic region, temperatures, and diagnosis method.

title: XXXX in the vector snails Pomacea canaliculata and Achatina fulica in China: a meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'Humans']

entities_list: @entity3853 :: ('MESH:C536369', 'Disease') :: ['Angiostrongyliasis']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['eosinophilic meningitis']

entities_list: @entity23699 :: ('6313', 'Species') :: ['Angiostrongylus cantonensis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections of snails']

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic disease']

answer: @entity23699 :: (6313,Species) :: ['Angiostrongylus cantonensis']


abstract: BACKGROUND: @entity731 is a chronic inflammatory process involving the immune system and formation of reactive @entity26 species (ROS). We investigated changes of mononuclear blood cells and ROS production in relation to the walking distance of @entity1 with @entity613 during home-based exercise training. METHODS: Forty @entity1 with @entity613 were asked to perform a home-based exercise training for a mean time of 12  months. ROS formation was measured using the @entity6931 analogue @entity42036 . Peripheral blood leucocytes [monocytes, polymorphonuclear neutrophils (PMN) and dendritic cells (DC)] were analysed by flow cytometry and analysed for the expression of major inflammatory surface molecules. RESULTS: At follow-up, @entity1 showed an increased walking distance and reduced ROS production upon stimulation with a @entity4621 derivative (PDBu) (p  <  0.01). Monocytes changed their inflammatory phenotype towards an increased anti-inflammatory @entity5750 (++) @entity4071 (-) subpopulation (p  <  0.0001). Adhesion molecules @entity9536 , @entity2935 and @entity15054 on monocytes and PMN decreased (all p  <  0.01). On DC expression of HLA-DR, @entity2937 or @entity2936 decreased at follow-up. Inflammatory markers like @entity2002 , C-reactive protein or soluble @entity15054 (sTREM-1) decreased over the observation period. Finally, we found a close relation of sTREM-1 with the walking distance, @entity2002 and ROS production. CONCLUSIONS: We observed an amelioration of the proinflammatory phenotype on monocytes, DC and PMN, as well as a reduced ROS production in PAD @entity1 under home-based exercise, paralleled by an increased walking distance. Our data suggest that a reduced inflammatory state might be achieved by regular walking exercise, possibly in a dimension proportionately to changes in walking distance.

title: Change of walking distance in XXXX : impact on inflammation, oxidative stress and mononuclear cells: a pilot study.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity4621 :: ('CHEBI:37532', 'Chemical') :: ['phorbol ester']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['intermittent claudication']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis']

answer: @entity613 :: (MESH:D007383,Disease) :: ['intermittent claudication']


abstract: PURPOSE: @entity933 is common after cardiac surgery and is associated with adverse consequences, including @entity73 . Identification of vulnerable older adults might allow for early implementation of @entity933 -prevention strategies. Brain MRI findings provide insight into structural brain changes that may identify vulnerable @entity1 . The purpose of this study was to examine the association between brain MRI characteristics potentially associated with @entity933 vulnerability and the development of @entity260 in a nested cohort of @entity1 undergoing cardiac surgery. METHODS: We identified 79 cardiac surgery @entity1 who had brain MRI imaging after cardiac surgery, as part of an ongoing randomized trial evaluating the efficacy of blood pressure management based on cerebral autoregulation monitoring versus standard management for improving neurological outcomes. Cerebral lateral ventricular size, cortical sulcal width, and @entity62 ( @entity62 ) on brain MRI scans were graded on a validated 0 to 9 scale, and categorized into tertiles. New @entity2806 were characterized as present or absent. @entity933 was assessed using a validated chart-review. Neuropsychological testing performed before surgery was used to establish preoperative cognitive baseline. Multivariable logistic regression was used to assess the independent association between MRI characteristics and @entity260 . FINDINGS: The average age of @entity1 was 70.1    7.8 years old, and 72% were male. Twenty-eight of 79 (35.4%) @entity1 developed @entity260 . @entity1 with @entity933 had higher unadjusted ventricular size (median 4 vs. 3, P = 0.003), and there was a trend towards higher sulcal sizes and @entity62 grades. Increasing tertiles of ventricular size (Odds Ratio [OR] 3.59; 95% Confidence Interval [CI] 1.59-8.12; P = 0.002) and sulcal size (OR 2.15; 95%CI 1.13-4.12; P = 0.02) were associated with @entity260 , with a trend for tertiles of @entity62 grade (OR 1.91; 95%CI 0.99-3.68; P = 0.05). In multivariable models adjusted for logistic EuroSCORE, baseline cognitive status, bypass time, and any @entity260 , each tertile of ventricular size was associated with increased odds of @entity260 (OR 3.23 per tertile increase in ventricular size; 95%CI 1.21-8.60; P = 0.02). There were no differences in odds of @entity933 by tertiles of sulcal grade, tertiles of white matter grade, or presence of new @entity2806 , in adjusted models. IMPLICATIONS: Increased brain ventricular size was independently associated with @entity933 after cardiac surgery. These results suggest that @entity194 may contribute to increased vulnerability for @entity260 . Baseline brain MRIs may be useful in identifying cardiac surgery @entity1 at high risk for @entity260 , who might benefit from targeted perioperative approaches to prevent @entity933 . ClinicalTrials.gov identifier: NCT00981474.

title: The Association of Brain MRI Characteristics and XXXX in Cardiac Surgery @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive decline']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative delirium', 'postoperative complication']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['cerebral atrophy']

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium', 'Delirium']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['WMH', 'white matter hyperintensities']

answer: @entity260 :: (MESH:D011183,Disease) :: ['Postoperative Delirium']


abstract: PURPOSE: @entity933 is common after cardiac surgery and is associated with adverse consequences, including @entity73 . Identification of vulnerable older adults might allow for early implementation of @entity933 -prevention strategies. Brain MRI findings provide insight into structural brain changes that may identify vulnerable @entity1 . The purpose of this study was to examine the association between brain MRI characteristics potentially associated with @entity933 vulnerability and the development of @entity260 in a nested cohort of @entity1 undergoing cardiac surgery. METHODS: We identified 79 cardiac surgery @entity1 who had brain MRI imaging after cardiac surgery, as part of an ongoing randomized trial evaluating the efficacy of blood pressure management based on cerebral autoregulation monitoring versus standard management for improving neurological outcomes. Cerebral lateral ventricular size, cortical sulcal width, and @entity62 ( @entity62 ) on brain MRI scans were graded on a validated 0 to 9 scale, and categorized into tertiles. New @entity2806 were characterized as present or absent. @entity933 was assessed using a validated chart-review. Neuropsychological testing performed before surgery was used to establish preoperative cognitive baseline. Multivariable logistic regression was used to assess the independent association between MRI characteristics and @entity260 . FINDINGS: The average age of @entity1 was 70.1    7.8 years old, and 72% were male. Twenty-eight of 79 (35.4%) @entity1 developed @entity260 . @entity1 with @entity933 had higher unadjusted ventricular size (median 4 vs. 3, P = 0.003), and there was a trend towards higher sulcal sizes and @entity62 grades. Increasing tertiles of ventricular size (Odds Ratio [OR] 3.59; 95% Confidence Interval [CI] 1.59-8.12; P = 0.002) and sulcal size (OR 2.15; 95%CI 1.13-4.12; P = 0.02) were associated with @entity260 , with a trend for tertiles of @entity62 grade (OR 1.91; 95%CI 0.99-3.68; P = 0.05). In multivariable models adjusted for logistic EuroSCORE, baseline cognitive status, bypass time, and any @entity260 , each tertile of ventricular size was associated with increased odds of @entity260 (OR 3.23 per tertile increase in ventricular size; 95%CI 1.21-8.60; P = 0.02). There were no differences in odds of @entity933 by tertiles of sulcal grade, tertiles of white matter grade, or presence of new @entity2806 , in adjusted models. IMPLICATIONS: Increased brain ventricular size was independently associated with @entity933 after cardiac surgery. These results suggest that @entity194 may contribute to increased vulnerability for @entity260 . Baseline brain MRIs may be useful in identifying cardiac surgery @entity1 at high risk for @entity260 , who might benefit from targeted perioperative approaches to prevent @entity933 . ClinicalTrials.gov identifier: NCT00981474.

title: The Association of Brain MRI Characteristics and @entity260 in Cardiac Surgery XXXX .

answer: @entity1 :: (9606,Species) :: ['Patients']