abstract: BACKGROUND: Monosodium @entity3264 (MSG) is often thought to be associated with @entity10 and craniofacial @entity158 like @entity2956 . This randomized, double-blinded, placebo-controlled study was performed to investigate how ingestion of MSG affects @entity925 sensitivity before and after experimentally induced @entity925 . METHODS: Sixteen healthy adult subjects participated in 2 sessions with at least 1-week interval between sessions. In each session, two injections of @entity3264 ( @entity367 , 0.5 M, 0.2 ml) and two injections of saline (0.9%, 0.2 ml) into the masseter and temporalis muscles, respectively, were undertaken, with a 15 min interval between each injection. Injections of saline were made contralateral to @entity367 injections and done in a randomized order. @entity1 drank 400 mL of soda mixed with either MSG (150 mg/kg) or @entity4202 (24 mg/kg, placebo) 30 min before the intramuscular injections. Pressure @entity158 thresholds (PPT), autonomic parameters and @entity158 intensity were assessed prior to (baseline) and 30 min after ingestion of soda, as well as 5 min and 10 min after the intramuscular injections and at the end of the session. Whole saliva samples were collected prior to and 30, 45, 60, and 75 min after the ingestion of soda. RESULTS: MSG administration resulted in a significantly higher @entity367 level in saliva than administration of @entity4202 and was associated with a significant @entity101 . Injections of @entity367 were significantly more @entity158 than injections of @entity4202 . However, ingestion of MSG did not change the intensity of @entity367 -evoked @entity158 . @entity367 injections also significantly increased systolic and diastolic blood pressure, but without an additional effect of MSG ingestion. @entity367 injections into the masseter muscle significantly reduced the PPT. However, pre-injection MSG ingestion did not significantly alter this effect. Interestingly, PPT was significantly increased in the trapezius after MSG ingestion and intramuscular injection of @entity367 in the jaw muscles. CONCLUSION: The main finding in this study was that systemic intake of a substantial amount of MSG does not influence either @entity158 intensity or pressure @entity158 sensitivity in the masseter and temporalis muscles into which @entity367 injections were made.

title: XXXX sensitivity after @entity3264 injection is not modified by systemic administration of monosodium glutamate.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['increase in systolic blood pressure']

entities_list: @entity2956 :: ('MESH:D013705', 'Disease') :: ['temporomandibular disorders']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful', 'pains']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle pain']

answer: @entity925 :: (MESH:D063806,Disease) :: ['Muscle pain']


abstract: BACKGROUND: Monosodium @entity3264 (MSG) is often thought to be associated with @entity10 and craniofacial @entity158 like @entity2956 . This randomized, double-blinded, placebo-controlled study was performed to investigate how ingestion of MSG affects @entity925 sensitivity before and after experimentally induced @entity925 . METHODS: Sixteen healthy adult subjects participated in 2 sessions with at least 1-week interval between sessions. In each session, two injections of @entity3264 ( @entity367 , 0.5 M, 0.2 ml) and two injections of saline (0.9%, 0.2 ml) into the masseter and temporalis muscles, respectively, were undertaken, with a 15 min interval between each injection. Injections of saline were made contralateral to @entity367 injections and done in a randomized order. @entity1 drank 400 mL of soda mixed with either MSG (150 mg/kg) or @entity4202 (24 mg/kg, placebo) 30 min before the intramuscular injections. Pressure @entity158 thresholds (PPT), autonomic parameters and @entity158 intensity were assessed prior to (baseline) and 30 min after ingestion of soda, as well as 5 min and 10 min after the intramuscular injections and at the end of the session. Whole saliva samples were collected prior to and 30, 45, 60, and 75 min after the ingestion of soda. RESULTS: MSG administration resulted in a significantly higher @entity367 level in saliva than administration of @entity4202 and was associated with a significant @entity101 . Injections of @entity367 were significantly more @entity158 than injections of @entity4202 . However, ingestion of MSG did not change the intensity of @entity367 -evoked @entity158 . @entity367 injections also significantly increased systolic and diastolic blood pressure, but without an additional effect of MSG ingestion. @entity367 injections into the masseter muscle significantly reduced the PPT. However, pre-injection MSG ingestion did not significantly alter this effect. Interestingly, PPT was significantly increased in the trapezius after MSG ingestion and intramuscular injection of @entity367 in the jaw muscles. CONCLUSION: The main finding in this study was that systemic intake of a substantial amount of MSG does not influence either @entity158 intensity or pressure @entity158 sensitivity in the masseter and temporalis muscles into which @entity367 injections were made.

title: @entity925 sensitivity after XXXX injection is not modified by systemic administration of monosodium glutamate.

answer: @entity3264 :: (D018698,Chemical) :: ['glutamate']


abstract: @entity64 is the second leading cause of @entity204 among adults worldwide. @entity3089 ( @entity3090 ) has been demonstrated to exhibit neuroprotective functions in @entity2806 /reperfusion injury. However, the underlying mechanisms in this process and its contribution to the protection function remain unknown. The current study examined the neuroprotective effects of @entity3090 after transient @entity2500 (tMCAO) in @entity35 . tMCAO for 120 min was induced in male @entity35 treated with @entity3090 (50 mg/kg, i.p.) or Vehicle immediately after reperfusion. Neurological score, @entity1188 ratio and inflammation-related molecules (assessed by @entity5045 , enzyme-linked immunosorbent assays, quantitative real-time PCR or western blotting) were estimated at 24 h after operation. @entity3090 prevented the @entity16 and decreased the @entity1188 volume, compared with the Vehicle group. The inflammation-related molecules @entity1505 , @entity3426 , @entity568 levels usually caused by @entity63 /reperfusion were significantly ameliorated by @entity3090 . @entity3090 also inhibited the upregulation of nuclear factor-kappa B/ @entity12149 (NF-kB/ @entity12149 ), and induction of cyclooxygenase 2 and inducible @entity842 synthase. The present study indicates that @entity3090 may be a promising therapeutic agent for @entity2806 /reperfusion injury through @entity32 .

title: Neuroprotective Effects of @entity3089 Against Focal XXXX /Reperfusion Injury in @entity35 Through Attenuation of Inflammation.

entities_list: @entity5045 :: ('MESH:C009591', 'Chemical') :: ['2,3,5-triphenyltetrazolium chloride']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['attenuation of inflammation']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery occlusion']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['impairment of neurological function']

entities_list: @entity3089 :: ('MESH:C045651', 'Chemical') :: ['(-)-Epigallocatechin-3-gallate']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'rats']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['Cerebral Ischemia']


abstract: @entity64 is the second leading cause of @entity204 among adults worldwide. @entity3089 ( @entity3090 ) has been demonstrated to exhibit neuroprotective functions in @entity2806 /reperfusion injury. However, the underlying mechanisms in this process and its contribution to the protection function remain unknown. The current study examined the neuroprotective effects of @entity3090 after transient @entity2500 (tMCAO) in @entity35 . tMCAO for 120 min was induced in male @entity35 treated with @entity3090 (50 mg/kg, i.p.) or Vehicle immediately after reperfusion. Neurological score, @entity1188 ratio and inflammation-related molecules (assessed by @entity5045 , enzyme-linked immunosorbent assays, quantitative real-time PCR or western blotting) were estimated at 24 h after operation. @entity3090 prevented the @entity16 and decreased the @entity1188 volume, compared with the Vehicle group. The inflammation-related molecules @entity1505 , @entity3426 , @entity568 levels usually caused by @entity63 /reperfusion were significantly ameliorated by @entity3090 . @entity3090 also inhibited the upregulation of nuclear factor-kappa B/ @entity12149 (NF-kB/ @entity12149 ), and induction of cyclooxygenase 2 and inducible @entity842 synthase. The present study indicates that @entity3090 may be a promising therapeutic agent for @entity2806 /reperfusion injury through @entity32 .

title: Neuroprotective Effects of XXXX Against Focal @entity2806 /Reperfusion Injury in @entity35 Through Attenuation of Inflammation.

answer: @entity3089 :: (MESH:C045651,Chemical) :: ['(-)-Epigallocatechin-3-Gallate']


abstract: @entity64 is the second leading cause of @entity204 among adults worldwide. @entity3089 ( @entity3090 ) has been demonstrated to exhibit neuroprotective functions in @entity2806 /reperfusion injury. However, the underlying mechanisms in this process and its contribution to the protection function remain unknown. The current study examined the neuroprotective effects of @entity3090 after transient @entity2500 (tMCAO) in @entity35 . tMCAO for 120 min was induced in male @entity35 treated with @entity3090 (50 mg/kg, i.p.) or Vehicle immediately after reperfusion. Neurological score, @entity1188 ratio and inflammation-related molecules (assessed by @entity5045 , enzyme-linked immunosorbent assays, quantitative real-time PCR or western blotting) were estimated at 24 h after operation. @entity3090 prevented the @entity16 and decreased the @entity1188 volume, compared with the Vehicle group. The inflammation-related molecules @entity1505 , @entity3426 , @entity568 levels usually caused by @entity63 /reperfusion were significantly ameliorated by @entity3090 . @entity3090 also inhibited the upregulation of nuclear factor-kappa B/ @entity12149 (NF-kB/ @entity12149 ), and induction of cyclooxygenase 2 and inducible @entity842 synthase. The present study indicates that @entity3090 may be a promising therapeutic agent for @entity2806 /reperfusion injury through @entity32 .

title: Neuroprotective Effects of @entity3089 Against Focal @entity2806 /Reperfusion Injury in XXXX Through Attenuation of Inflammation.

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: The function of the metrial gland of the @entity35 , and particularly of its characteristic population of granulated cells, remains unknown. However, several lines of evidence suggest that the granulated cells may derive from lymphocytes, and play a role in the immunology of pregnancy. In this study, antigen expression by granulated and other cell populations from the metrial glands of @entity35 at Days 13 and 14 of pregnancy was studied by an indirect immunoperoxidase method. @entity1324 -fixed frozen sections, and cytocentrifuge preparations of collagenase-dispersed metrial gland tissue in which numbers of granulated cells had been increased by density-gradient centrifugation, were used. The primary antibodies used recognised, inter alia, B lymphocytes (MRC OX-3, MRC OX-6, MRC OX-12), T lymphocytes (MRC OX-8, @entity11264 , MRC OX-19), neutrophils (MRC OX-42) and cells of the monocyte/macrophage series (MRC OX-3, MRC OX-6, MRC OX-42, MRC OX-43). The majority of the granulated cells, including smaller, "immature" forms, were unlabelled by any of these antibodies. Some lymphocytes, and varying numbers of larger, non-granulated cells, were labelled by OX-6, OX-12, @entity11264 , OX-42 and OX-43. In addition to lymphocytes, labelled cells included neutrophils (OX-42), endothelial cells (OX-43), and probably some macrophages (OX-6, OX-43). OX-12, which recognises the kappa chain of rat IgG, labelled some large cells which may have been stromal cells. These findings do not support the concept that the granulated cells are derived from lymphocytes.

title: Expression of leucocyte antigens by cells from the metrial gland of the pregnant XXXX .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Over a 12-year period between 1979 and 1991, 27 @entity1 were operated on at the New York University Medical Center for salvage of below-knee @entity11768 utilizing free flaps. Six different donor sites were used. In 6 @entity1 , the amputated foot was the donor site for a free flap to cover the tibial stump. There were 3 males and 3 females in this group. Five of the @entity1 underwent immediate filet of foot reconstructions, while 1 @entity1 had a reconstruction performed 69 days after injury, electively, when it was determined that below-knee amputation was the best option. All foot flaps survived and ultimately provided the major soft-tissue coverage for the below-knee amputation stump. The length of hospitalization ranged from 24 to 118 days. The time required from foot filet procedure to ambulation was 2, 4, 6, 7, 9, and 12 months in the 6 @entity1 . Five of the 6 @entity1 have resumed work or school after their injury. Foot flaps were based on the posterior tibial artery, anterior tibial artery, or both vessels. Nerve @entity254 of the posterior tibial nerve was performed in 5 @entity1 . In 1 @entity1 it was possible to maintain the continuity of the posterior tibial nerve. Five of the 6 @entity1 were tested over a year after the flap, and all have good cold, pressure, and vibration sensation. Two of the 5 @entity1 have heat sensation, and all 5 @entity1 have at least protective pressure sensation. All the @entity1 ambulate well with a below-knee prosthesis.

title: Salvage of traumatic below-knee XXXX utilizing the filet of foot free flap: critical evaluation of six cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity11768 :: ('MESH:C565682', 'Disease') :: ['amputation stumps']

answer: @entity11768 :: (MESH:C565682,Disease) :: ['amputation stumps']


abstract: INTRODUCTION: @entity14818 ( @entity14818 ) is a disabling @entity8649 , characterized by a chronic @entity1910 , an M-protein, @entity4841 , and other signs of systemic @entity32 . @entity1356 ( @entity1356 antibodies are highly effective, but the pathophysiology is still largely unknown. Here we studied the effect of in-vivo @entity1356 inhibition on serum markers of @entity32 and cellular immune responses. METHODS: Eight @entity1 with @entity14818 received monthly subcutaneous (s.c.) injections with 150 mg canakinumab for six months. Blood was drawn for measurement of serum markers of @entity32 (12 times per @entity1 ) and for functional and phenotypic analysis of both freshly isolated and toll-like receptor (TLR)-ligand-stimulated peripheral blood mononuclear cells (PBMCs) (five times per @entity1 ). All data were compared to results of healthy controls. RESULTS: @entity650 levels in serum and in lysates of freshly isolated PBMCs and serum myeloid-related protein ( @entity11773 )/14 and S100A12 levels correlated with disease activity. In vitro, @entity558 stimulation resulted in higher @entity650 and @entity1356 production in PBMCs from symptomatic @entity14818 @entity1 compared to healthy controls, whereas @entity1 cells were relatively hyporesponsive to poly:IC and Pam3Cys. The mRNA microarray of PBMCs showed distinct transcriptomes for controls, symptomatic patients and anti- @entity1356 -treated @entity1 . Numbers of T- and B-cell subsets as well as M-protein concentrations were not affected by @entity1356 inhibition. Free light chain levels were elevated in 4 out of 8 @entity1 . CONCLUSIONS: In conclusion, @entity1 PBMCs are hyperresponsive to @entity558 , and clinical efficacy of @entity1356 inhibition in @entity1 with @entity14818 is associated with in-vivo and ex-vivo suppression of @entity32 . Interestingly, @entity1 PBMCs showed divergent responses to @entity26165 , @entity6800 and @entity2939 ligands. Our data underscore that @entity1356 plays a pivotal role in @entity14818 .

title: The role of @entity1356 in the pathophysiology of XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity14818 :: ('MESH:D019873', 'Disease') :: ['SchS', "Schnitzler's syndrome"]

entities_list: @entity1910 :: ('MESH:D005076', 'Disease') :: ['urticarial rash']

entities_list: @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia']

entities_list: @entity8649 :: ('MESH:D056660', 'Disease') :: ['autoinflammatory disorder']

answer: @entity14818 :: (MESH:D019873,Disease) :: ['Schnitzler's syndrome']


abstract: INTRODUCTION: @entity14818 ( @entity14818 ) is a disabling @entity8649 , characterized by a chronic @entity1910 , an M-protein, @entity4841 , and other signs of systemic @entity32 . @entity1356 ( @entity1356 antibodies are highly effective, but the pathophysiology is still largely unknown. Here we studied the effect of in-vivo @entity1356 inhibition on serum markers of @entity32 and cellular immune responses. METHODS: Eight @entity1 with @entity14818 received monthly subcutaneous (s.c.) injections with 150 mg canakinumab for six months. Blood was drawn for measurement of serum markers of @entity32 (12 times per @entity1 ) and for functional and phenotypic analysis of both freshly isolated and toll-like receptor (TLR)-ligand-stimulated peripheral blood mononuclear cells (PBMCs) (five times per @entity1 ). All data were compared to results of healthy controls. RESULTS: @entity650 levels in serum and in lysates of freshly isolated PBMCs and serum myeloid-related protein ( @entity11773 )/14 and S100A12 levels correlated with disease activity. In vitro, @entity558 stimulation resulted in higher @entity650 and @entity1356 production in PBMCs from symptomatic @entity14818 @entity1 compared to healthy controls, whereas @entity1 cells were relatively hyporesponsive to poly:IC and Pam3Cys. The mRNA microarray of PBMCs showed distinct transcriptomes for controls, symptomatic patients and anti- @entity1356 -treated @entity1 . Numbers of T- and B-cell subsets as well as M-protein concentrations were not affected by @entity1356 inhibition. Free light chain levels were elevated in 4 out of 8 @entity1 . CONCLUSIONS: In conclusion, @entity1 PBMCs are hyperresponsive to @entity558 , and clinical efficacy of @entity1356 inhibition in @entity1 with @entity14818 is associated with in-vivo and ex-vivo suppression of @entity32 . Interestingly, @entity1 PBMCs showed divergent responses to @entity26165 , @entity6800 and @entity2939 ligands. Our data underscore that @entity1356 plays a pivotal role in @entity14818 .

title: The role of XXXX in the pathophysiology of @entity14818 .

answer: @entity1356 :: (3553,Gene) :: ['interleukin-1 beta']


abstract: UNASSIGNED: Background The appropriate management of @entity22 is crucial and prescribing of hypnotic drugs is common. Regular and prolonged use of hypnotics should be avoided because of the risk of tolerance to effects, @entity734 and an increased risk of adverse events. In 2012, updated Beers criteria for potentially inappropriate medication in older adults suggested to avoid all @entity1245 in older adults to treat @entity22 . In addition, successful discontinuation may result in improvements on @entity73 , particularly in older @entity1 . Objective To investigate the appropriateness of @entity1245 prescription for @entity22 and explore the role that community pharmacists can have in identifying signals of potential inappropriate drug prescriptions. Setting Community pharmacies in Italy. Method This is an observational study conducted in 8 community pharmacies. Each pharmacist was asked to interview a sample of @entity1 with the prescriptions of at least one @entity1245 and to complete a minimum data set collecting information about socio-demographic characteristics, drug indication, duration of drug prescription, number of hypnotic-drugs, previous attempt to drug-discontinuation, preference of @entity1 about @entity1245 withdrawal and modality of drug tapering. Main outcome measure Indications, treatment duration, dosage and drug discontinuation attempts and modalities. Results A total of 181 @entity1 were interviewed. About half of respondents (n  =  81) reported to be treated for @entity22 and 62  % were elderly (mean age 68, range 27-93). Fifty-two @entity1 (64  %) were on long term treatment (>3  years) while for thirteen @entity1 (16  %) duration of treatment was comprised between 1 and 3  years. Thirty-three @entity1 were in favour of @entity1245 -discontinuation but in all cases discontinuation was unsuccessful. Conclusion Use of community pharmacy survey data allowed us to obtain information about incorrect management of @entity22 and inappropriate @entity1245 prescriptions. Stricter adherence to evidence-based guidelines is essential for a rational use of hypnotic and sedatives.

title: Role of community pharmacists in the detection of potentially inappropriate XXXX prescriptions for @entity22 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'people']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive and psychomotor function']

entities_list: @entity1245 :: ('MESH:D001569', 'Chemical') :: ['benzodiazepine', 'benzodiazepines']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['dependence']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['chronic insomnia', 'insomnia']

answer: @entity1245 :: (MESH:D001569,Chemical) :: ['benzodiazepines']


abstract: UNASSIGNED: Background The appropriate management of @entity22 is crucial and prescribing of hypnotic drugs is common. Regular and prolonged use of hypnotics should be avoided because of the risk of tolerance to effects, @entity734 and an increased risk of adverse events. In 2012, updated Beers criteria for potentially inappropriate medication in older adults suggested to avoid all @entity1245 in older adults to treat @entity22 . In addition, successful discontinuation may result in improvements on @entity73 , particularly in older @entity1 . Objective To investigate the appropriateness of @entity1245 prescription for @entity22 and explore the role that community pharmacists can have in identifying signals of potential inappropriate drug prescriptions. Setting Community pharmacies in Italy. Method This is an observational study conducted in 8 community pharmacies. Each pharmacist was asked to interview a sample of @entity1 with the prescriptions of at least one @entity1245 and to complete a minimum data set collecting information about socio-demographic characteristics, drug indication, duration of drug prescription, number of hypnotic-drugs, previous attempt to drug-discontinuation, preference of @entity1 about @entity1245 withdrawal and modality of drug tapering. Main outcome measure Indications, treatment duration, dosage and drug discontinuation attempts and modalities. Results A total of 181 @entity1 were interviewed. About half of respondents (n  =  81) reported to be treated for @entity22 and 62  % were elderly (mean age 68, range 27-93). Fifty-two @entity1 (64  %) were on long term treatment (>3  years) while for thirteen @entity1 (16  %) duration of treatment was comprised between 1 and 3  years. Thirty-three @entity1 were in favour of @entity1245 -discontinuation but in all cases discontinuation was unsuccessful. Conclusion Use of community pharmacy survey data allowed us to obtain information about incorrect management of @entity22 and inappropriate @entity1245 prescriptions. Stricter adherence to evidence-based guidelines is essential for a rational use of hypnotic and sedatives.

title: Role of community pharmacists in the detection of potentially inappropriate @entity1245 prescriptions for XXXX .

answer: @entity22 :: (MESH:D007319,Disease) :: ['insomnia']


abstract: OBJECTIVE: To assess clinical outcomes and cost-effectiveness of using a two-layer cohesive compression bandage (TLCCB; Coban 2) compared with a two-layer compression system (TLCS; Ktwo) and a four-layer compression system (FLCS; Profore) in treating @entity3179 ( @entity3179 ) in clinical practice in the UK, from the perspective of the National Health Service (NHS). METHOD: This was a retrospective analysis of the case records of VLU @entity1 , randomly extracted from @entity283 ( @entity283 ) database (a nationally representative database of clinical practice among @entity1 registered with general practitioners in the UK), who were treated with either TLCCB (n=250), TLCS (n=250) or FLCS (n=175). Clinical outcomes and health-care resource use (and costs) over six months after starting treatment with each compression system were estimated. Differences in outcomes and resource use between treatments were adjusted for differences in baseline covariates. RESULTS: @entity1 ' mean age was 75 years old and 57% were female. The mean time with a VLU was 6-7 months and the mean initial wound size was 77-85 cm2. The overall VLU healing rate, irrespective of bandage type, was 44% over the six months' study period. In the TLCCB group, 51% of wounds had healed by six months compared with 40% (p=0.03) and 28% (p=0.001) in the TLCS and FLCS groups, respectively. The mean time to healing was 2.5 months. @entity1 in the TLCCB group experienced better health-related quality of life (HRQoL) over six months (0.374 quality-adjusted life years (QALYs) per @entity1 ), compared with the TLCS (0.368 QALYs per @entity1 ) and FLCS (0.353 QALYs per @entity1 ). The mean six-monthly NHS management cost was   2,413,   2,707 and   2,648 per @entity1 in the TLCCB, TLCS and FLCS groups, respectively. CONCLUSION: Despite the systems studied reporting similar compression levels when tested in controlled studies, real-world evidence demonstrates that initiating treatment with TLCCB, compared with the other two compression systems, affords a more cost-effective use of NHS-funded resources in clinical practice, since it resulted in an @entity101 and a reduction in NHS management cost. The evidence also highlighted the lack of continuity between clinicians managing a wound, the inconsistent nature of the administered treatments and the lack of specialist involvement, all of which may impact on healing. DECLARATION OF INTEREST: This study was supported by an unrestricted research grant from 3M Health Care, UK. 3M Health Care had no influence on the study design, the collection, analysis, and interpretation of data, or on the writing of, and decision to submit for publication, the manuscript.

title: Clinical outcomes and cost-effectiveness of three alternative compression systems used in the management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['increased healing rate, better HRQoL']

entities_list: @entity283 :: ('OMIM:603663', 'Disease') :: ['THIN', 'The Health Improvement Network']

entities_list: @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous leg ulcers', 'VLUs']

answer: @entity3179 :: (MESH:D014647,Disease) :: ['venous leg ulcers']


abstract: This report summarizes a recent 24-month experience with 9 @entity1 who were treated for injuries to the innominate or subclavian arteries at a large urban hospital. All @entity1 were male, age range was 17 to 47 years, and mean age was 29 years. The mechanism of injury included major arterial @entity155 sustained during @entity5 operations at the base of the neck (2), @entity1913 secondary to motor vehicle accidents (2), stab wounds (1), and gunshot wounds (4). The vessels injured included the right subclavian artery (2), the innominate artery (1), and the left subclavian artery (6). Associated major @entity1317 were seen in 4 cases (44%) and major @entity1317 in 5 cases (55%). Arterial exposure involved a variety of incisions, including left thoracotomy, median sternotomy, clavicular resection, or a combination of these. Arterial continuity was restored in all cases using primary repair (2), autogenous saphenous vein graft (6), or prosthetic graft (1). @entity1317 were treated by ligation (2) or lateral venorraphy (2). One @entity1 died unexpectedly on the tenth postoperative day for an overall mortality of 11 percent. Three of the 8 survivors sustained nonfatal complications (38%). All 8 survivors had patent arterial repairs at the time of hospital discharge, and 5 of 8 survivors were available for follow-up with intravenous digital subtraction angiography (DSA), revealing arterial repair patency in all.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Subclavian and innominate artery trauma: a recent experience with nine XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity155 :: ('MESH:D014084', 'Disease') :: ['avulsions']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['venous injuries', 'non-vascular injuries', 'Venous injuries']

entities_list: @entity1913 :: ('MESH:D014949', 'Disease') :: ['blunt injuries']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: To evaluate the effectiveness of intraarterial infusion chemotherapy (IAC) with @entity2664 in @entity1 with previously treated, locally recurrent @entity0 . MATERIALS AND METHODS: Thirty-nine @entity1 (aged 31-82 years) with recurrent @entity0 underwent superselective IAC (25 mg/m2 @entity2664 every 24 hours) through the subclavian artery branches after heparin administration. The extent of @entity5 perfusion was monitored with computed tomography during the intraarterial administration of contrast medium. IAC was repeated one to nine times. @entity1 had previously undergone radiation therapy (n = 39), surgery (n = 20), or systemic chemotherapy (n = 23). RESULTS: The overall response rate was 77% (n = 30). Eight @entity1 had complete remission. Progression occurred in three @entity1 . Remission was observed in cases of lymph node involvement (n = 9). Seven @entity1 are still undergoing treatment. Side effects were usually moderate. Nine @entity1 died of systemic @entity5 spread. In 14 @entity1 , distant metastases developed during the first 18 months of treatment. CONCLUSION: IAC is an effective, well-tolerated therapy in @entity1 with locally recurrent @entity0 .

title: Previously treated, locally recurrent XXXX : treatment with superselective intraarterial chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity2664 :: ('MESH:D008942', 'Chemical') :: ['mitoxantrone hydrochloride']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: OBJECTIVE: Despite extensive research into the treatment of @entity121 , to date there has not been the emergence of a preeminent modality. This pilot study, the first such study to be performed in a burn unit in the US, was designed to evaluate the efficacy and outcomes of the application of copolymer dressing (Suprathel; PolyMedics Innovations Corporation, Stuttgart, Germany) for both superficial and deeper @entity121 . METHOD: The copolymer dressing was used as a primary wound dressing to treat superficial and deep @entity121 (average 5% total body surface area) in paediatric @entity1 . Burns were debrided within 24 hours, at bedside, in the burn unit or in the operating room. The copolymer dressing was then applied directly to the wound and covered with a non-adherent second layer and an absorptive outer dressing. After discharge, @entity1 were seen every 5-7 days until healed. Parameters evaluated included average hospital length of stay, average number of intravenous doses of narcotics administered, @entity158 score at first follow-up visit, average time to complete re epithelialisation, incidence of @entity2737 , and @entity1 /parent satisfaction on a 4-point scale. We also evaluated our experience with the dressing. Data were evaluated retrospectively under an Investigational Review Board approved protocol. RESULTS: Of the 17 @entity1 assessed the average hospital length of stay was 1.4 days during which the average number of intravenous narcotic doses administered before copolymer dressing application was 1.5 and after was 0.1 doses. At the first follow-up visit, average @entity158 score was 1.2 on a 10-point scale and the average time to re epithelialisation was 9.5 days. There was no incidence of @entity2737 . @entity1 /parent satisfaction was average of 3.66 on a 4-point scale. The staff had found that the self-adherence and elasticity of the dressing made it easy to apply and stay adherent, especially in areas of difficult contour. There were no readmissions for further debridement or skin grafting. CONCLUSION: Our experience shows that @entity1 may be discharged shortly after the application of the copolymer dressing, with manageable @entity158 scores and ease of use as determined by the caretakers high satisfaction. This new, fully synthetic copolymer dressing is easy to apply, does not require any additional antimicrobial coverage and may be used to successfully manage deeper @entity121 , donor sites or burns in areas of contour, where many other dressings might not be considered or be appropriate. DECLARATION OF INTEREST: None declared.

title: Use of a copolymer dressing on superficial and XXXX in a paediatric population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['partial-thickness burns']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['burn wound infection']

answer: @entity121 :: (MESH:D009135,Disease) :: ['partial-thickness burns']


abstract: PURPOSE: To present outcomes in a series of @entity1 with @entity4243 ( @entity4243 )-hypermobility type who underwent hip arthroscopy for associated @entity158 and extreme capsular laxity. METHODS: A retrospective chart review identified 16 hips with confirmed @entity4243 --hypermobility type that underwent hip arthroscopy for continued @entity158 and capsular laxity. All @entity1 had complaints of "giving way" and @entity158 , an easily distractible hip with manual traction under fluoroscopy, and a patulous capsule at the time of surgery. No @entity1 had osseous evidence of acetabular @entity572 or prior confirmed @entity572 . Outcomes were evaluated preoperatively and postoperatively with the modified Harris Hip Score (mHHS), the 12-Item Short Form Health Survey (SF-12), and a visual analog scale (VAS) for @entity158 . RESULTS: Evidence of symptomatic @entity1743 ( @entity1743 ) was found in 15 hips (93.8%). The 16th hip had subjective giving way with a positive anterior impingement test and was easily distractible, had a labral tear, and had a patulous capsule at the time of surgery. The mean follow-up period was 44.61 months (range, 12 to 99 months). The mean preoperative lateral center-edge angle was 31.8   (range, 25   to 44  ), and the mean T  nnis angle was 3.6   (range, -2   to 8  ). Mean femoral version measured on computed tomography (CT) scans was 19.2   (range, -4.0   to 31.0  ). Of the hips, 13 underwent primary arthroscopy and 3 underwent revision. All hips underwent hip arthroscopy with an interportal capsular cut only and arthroscopic capsular plication. There were 13 labral repairs, 2 labral debridements, 8 rim resections, 15 femoral resections, 2 psoas tenotomies, and 1 microfracture. Improved stability with an inability to distract the hip with manual traction under fluoroscopy was noted in all hips after plication. The mean alpha angle preoperatively was 58.7   on anteroposterior radiographs and 63.6   on lateral radiographs compared with 47.4   and 46.1  , respectively, postoperatively. There were significant improvements for all outcomes (mHHS, P = .002; SF-12 score, P = .027; and VAS score, P = .0004). The mean mHHS, SF-12 score, and VAS score were 45.6 points, 62.4 points, and 6.5 points, respectively, preoperatively compared with 88.5 points, 79.3 points, and 1.6 points, respectively, at a mean follow-up of 45 months. No @entity4243 @entity1 were lost to follow-up or excluded from analysis. The mean improvement in mHHS from preoperatively to postoperatively was 42.9 points, and there were no @entity4499 . One @entity1 underwent further revision arthroscopy for recurrent @entity158 , subjective giving way, and capsular laxity. CONCLUSIONS: @entity1743 and extreme capsular laxity can be seen in the setting of @entity4243 . Although @entity2096 was common, @entity7195 was not common in our study. Meticulous capsular plication, arthroscopic correction of @entity1743 when present, and labral preservation led to dramatic improvements in outcomes and subjective stability without any @entity4499 in this potentially challenging @entity1 population. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

title: XXXX : Arthroscopic Management for Extreme Soft-Tissue Hip Instability.

entities_list: @entity4499 :: ('MESH:D007049', 'Disease') :: ['iatrogenic dislocations']

entities_list: @entity7195 :: ('OMIM:142700', 'Disease') :: ['acetabular dysplasia']

entities_list: @entity1743 :: ('MESH:D057925', 'Disease') :: ['femoroacetabular impingement', 'FAI']

entities_list: @entity4243 :: ('MESH:D004535', 'Disease') :: ['Ehlers-Danlos syndrome', 'EDS']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['hip dislocation', 'hip dysplasia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['hip pain', 'pain']

entities_list: @entity2096 :: ('MESH:D020428', 'Disease') :: ['increased femoral version']

answer: @entity4243 :: (MESH:D004535,Disease) :: ['Ehlers-Danlos Syndrome']


abstract: PURPOSE: To assess treatment efficacy using spectral-domain (SD) optical coherence tomography (OCT) measurements of @entity1829 in the @entity5576 Treatment Trial (IIHTT), which evaluated the effects of @entity3791 and weight management and of placebo and weight management in eyes with mild @entity227 . DESIGN: Randomized double-masked control clinical trial of @entity3791 plus weight management compared with placebo plus weight management in subjects with mild @entity227 and previously untreated @entity5576 ( @entity5576 ). @entity1 : Eighty-nine (43 @entity3791 treated, 46 placebo treated) of 165 subjects meeting IIHTT entry criteria. METHODS: Subjects underwent perimetry, @entity1829 grading (Fris  n method), high- and low-contrast visual acuity, and SD OCT imaging at study entry and 3 and 6 months. Study eye results (worse @entity5494 [ @entity5494 ]) were used for most analyses. MAIN OUTCOME MEASURES: Retinal nerve fiber layer (RNFL) thickness, total retinal thickness (TRT), optic nerve (ONH) volume, and @entity989 ( @entity989 ) measurements derived using 3-dimensional segmentation. RESULTS: Study entry OCT values were similar in both treatment groups. At 6 months, the @entity3791 group had greater reduction than the placebo group for RNFL thickness (175  m vs. 89  m; P  = 0.001), TRT (220  m vs. 113  m; P  = 0.001), and ONH volume (4.9 mm(3) vs. 2.1 mm(3); P  = 0.001). The RNFL thickness (P  = 0.01), TRT (P  = 0.003), and ONH volume (P  = 0.002) measurements also showed smaller increases in subjects who lost 6% or more of study entry weight. The @entity3791 (3.6  m) and placebo (2.1  m) groups showed minor @entity989 thinning (P  = 0.06). The RNFL thickness, TRT, and ONH volume measurements showed moderate correlations (r  = 0.48-0.59; P  <= 0.0001) with Fris  n grade. The 14 eyes with @entity989 thickness less than the fifth percentile of controls had worse @entity5494 (P  = 0.001) than study eyes with @entity989 in the fifth percentile or more. CONCLUSIONS: In @entity5576 , @entity3791 and weight loss effectively improve RNFL thickness, TRT, and ONH @entity4 measurements resulting from @entity1829 . In contrast to the strong correlation at baseline, OCT measures at 6 months show only moderate correlations with @entity1829 grade.

title: XXXX Outcomes from the Optical Coherence Tomography Substudy of the @entity5576 Treatment Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'visual field loss']

entities_list: @entity5494 :: ('MESH:D010262', 'Disease') :: ['PMD', 'perimetric mean deviation']

entities_list: @entity3791 :: ('MESH:D000086', 'Chemical') :: ['acetazolamide']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['volume swelling']

entities_list: @entity1829 :: ('MESH:D010211', 'Disease') :: ['papilledema']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal ganglion cell layer', 'RGCL']

entities_list: @entity5576 :: ('MESH:D011559', 'Disease') :: ['Idiopathic Intracranial Hypertension', 'idiopathic intracranial hypertension', 'IIH']

answer: @entity1829 :: (MESH:D010211,Disease) :: ['Papilledema']


abstract: PURPOSE: To assess treatment efficacy using spectral-domain (SD) optical coherence tomography (OCT) measurements of @entity1829 in the @entity5576 Treatment Trial (IIHTT), which evaluated the effects of @entity3791 and weight management and of placebo and weight management in eyes with mild @entity227 . DESIGN: Randomized double-masked control clinical trial of @entity3791 plus weight management compared with placebo plus weight management in subjects with mild @entity227 and previously untreated @entity5576 ( @entity5576 ). @entity1 : Eighty-nine (43 @entity3791 treated, 46 placebo treated) of 165 subjects meeting IIHTT entry criteria. METHODS: Subjects underwent perimetry, @entity1829 grading (Fris  n method), high- and low-contrast visual acuity, and SD OCT imaging at study entry and 3 and 6 months. Study eye results (worse @entity5494 [ @entity5494 ]) were used for most analyses. MAIN OUTCOME MEASURES: Retinal nerve fiber layer (RNFL) thickness, total retinal thickness (TRT), optic nerve (ONH) volume, and @entity989 ( @entity989 ) measurements derived using 3-dimensional segmentation. RESULTS: Study entry OCT values were similar in both treatment groups. At 6 months, the @entity3791 group had greater reduction than the placebo group for RNFL thickness (175  m vs. 89  m; P  = 0.001), TRT (220  m vs. 113  m; P  = 0.001), and ONH volume (4.9 mm(3) vs. 2.1 mm(3); P  = 0.001). The RNFL thickness (P  = 0.01), TRT (P  = 0.003), and ONH volume (P  = 0.002) measurements also showed smaller increases in subjects who lost 6% or more of study entry weight. The @entity3791 (3.6  m) and placebo (2.1  m) groups showed minor @entity989 thinning (P  = 0.06). The RNFL thickness, TRT, and ONH volume measurements showed moderate correlations (r  = 0.48-0.59; P  <= 0.0001) with Fris  n grade. The 14 eyes with @entity989 thickness less than the fifth percentile of controls had worse @entity5494 (P  = 0.001) than study eyes with @entity989 in the fifth percentile or more. CONCLUSIONS: In @entity5576 , @entity3791 and weight loss effectively improve RNFL thickness, TRT, and ONH @entity4 measurements resulting from @entity1829 . In contrast to the strong correlation at baseline, OCT measures at 6 months show only moderate correlations with @entity1829 grade.

title: @entity1829 Outcomes from the Optical Coherence Tomography Substudy of the XXXX Treatment Trial.

answer: @entity5576 :: (MESH:D011559,Disease) :: ['Idiopathic Intracranial Hypertension']


abstract: Concomitant radiochemotherapy (CRC) is based on the administration of chemotherapeutic agents concurrently with radiation therapy. It is aimed at the spatial cooperation of radiotherapy ( @entity18437 ) and chemotherapy and the enhancement of the local action of radiotherapy. In this study the role of @entity18437 enhancement in the treatment of @entity5 , is analyzed. 5FU is the commonly used drug. Clinical and experimental evidence indicates radiotherapy to be enhanced when the drug is administered in continuous infusion after radiation and for a suitable dose of 5FU. In these conditions, @entity137 is usually mild. In contrast, when the drug is administered as bolus, the experimental evidence seems to indicate only additivity. However the clinical experience has shown an improvement in local control and survival at the expense of a higher @entity137 . In @entity1 with resectable lesions at high risk for local recurrence, randomized CRC studies have shown a high rate of local control between 85% and 90%, a 5-year survival between 55% and 60%, significantly better as compared to control arms: exclusive surgery (GITSG7 175), exclusive @entity18437 (NCCTG), bolus CRC (Intergroup). Acute @entity137 is mostly hematological and gastrointestinal. In @entity1 with lesions unresectable for cure, CRC allows high surgical radicality (85-90%). Complete pathologic response is 4 to 20%. Local control is high (80-90%) and 3-year survival is 70 to 90%. Grade 3-4 acute gastrointestinal @entity137 was shown to be higher in combinations with bolus 5FU. In recurrence CRC has been used for palliation. Control of @entity158 to the pelvis was similar to that achieved with radiotherapy alone. In a single experience was CRC used preoperatively and results seem encouraging.

title: Concomitant radiochemotherapy in XXXX : methodology and indications.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']


abstract: OBJECT: Stereotactic radiosurgery serves as an important primary and adjuvant treatment option for @entity1 with many types of @entity1653 . This is particularly true for @entity1 with @entity1653 . In this study, the authors evaluated the outcomes of Gamma Knife surgery (GKS) used to treat @entity1653 . METHODS: The study is a retrospective review of the outcomes in 138 @entity1 with @entity1653 treated at the University of Virginia from 1989 to 2006; all @entity1 had a minimum follow-up of 24 months. There were 31 @entity1 and 107 @entity1 whose mean age was 54 years (range 19-85 years). Eighty-four @entity1 had previously undergone resection. The mean pre-GKS @entity5 volume was 7.5 ml (range 0.2-54.8 ml). Clinical and radiographic evaluations were performed, and factors related to favorable outcomes in each case were assessed. RESULTS: The mean follow-up duration was 84 months (median 75.5 months, range 24-216 months). In 118 @entity1 (86%), the @entity5 volume was unchanged or had decreased at last follow-up. Kaplan-Meier analysis demonstrated radiographic progression-free survival at 5 and 10 years to be 95.4% and 69%, respectively. Fourteen @entity1 (10%) developed new @entity129 following GKS. Factors associated with @entity5 control included younger age, a higher isodose, and smaller @entity5 volume. A longer follow-up duration was associated with either a decrease or increase in @entity5 volume. Fourteen @entity1 (10%) experienced new or worsening @entity129 after treatment. Factors associated with this occurrence were larger pretreatment @entity5 volume, lower peripheral radiation dose, lower maximum dose, @entity5 progression, and longer follow-up. CONCLUSIONS: Gamma Knife surgery offers an acceptable rate of @entity5 control for @entity1653 and accomplishes this with a low incidence of @entity51 . Radiological control after radiosurgery is more likely in those @entity1 with a smaller @entity5 volume and a higher prescription dose.

title: Gamma Knife surgery for XXXX : long-term results including complications, predictive factors, and progression-free survival.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve deficits', 'cranial nerve palsies']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits']

entities_list: @entity1653 :: ('MESH:D008579', 'Disease') :: ['intracranial meningiomas', 'meningiomas', 'parasellar meningiomas']

answer: @entity1653 :: (MESH:D008579,Disease) :: ['parasellar meningiomas']


abstract: Resistive index (RI) calculation on Doppler tracing of intrarenal arterial blood flow is a sensitive method for the early diagnosis of @entity3551 . However, the RI is not specific and can increase in a number of other conditions, e.g., old age, circulating endogenic factors or drugs, other @entity8 . The authors investigated RI usefulness and accuracy by measuring it both before and after the radiologic treatment of acute @entity1876 in 21 @entity1 , 9 of whom had @entity177 due to other causes, i.e., @entity101 , @entity6 and chronic @entity2885 . The clinical conditions of the @entity1 limited the feasibility of RI measurements before and after nephrostomy to 66%. In 22 kidneys in 17 @entity1 examined before nephrostomy, the RI ranged 0.63 to 0.93 (mean: 0.80); when the obstruction was unilateral, the RI was always higher than in the contralateral kidney. In 25 kidneys in 18 @entity1 examined after nephrostomy, the mean RI value was 0.68 (15% lower than before). Taking 0.7 as the cut-off value, RI sensitivity in detecting acute @entity1876 was high (about 90%), while its specificity was low (about 50%); specificity increased (to about 80%) when other concomitant causes of increased intrarenal arterial resistance, e.g., other vascular or parenchymal @entity8 , were not considered. In some cases, the method was also useful in excluding the presence of recurrent obstruction after ureteral stent removal. In conclusion, Doppler US values of intrarenal arterial perfusion are indicative of acute @entity1876 when they can be compared with those from the contralateral healthy kidney or when they can be measured, in the same @entity1 , before and after decompressive nephrostomy. In other cases, other @entity8 and some technical limitations must be considered.

title: [Doppler ultrasonography of the intrarenal arteries before and after radiologic treatment in XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3551 :: ('MESH:C536483', 'Disease') :: ['obstructive uropathy']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathies']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis']

entities_list: @entity1876 :: ('MESH:D001748', 'Disease') :: ['urinary obstruction']

answer: @entity3551 :: (MESH:C536483,Disease) :: ['obstructive uropathy']


abstract: CT was used to localize and guide the percutaneous ablation of @entity10545 in 11 @entity1 whose age ranged 5 to 63 years. The treatment was performed directly in the CT room ensuring maximum asepsis. General anesthesia was used in @entity1 and in vertebral and sacroiliac localizations, while the peripheral block was used in peripheral localizations. In the latter cases, an @entity63 band was used to reduce @entity548 . A dedicated drill resection system guided by a Kirschner guide wire was used for removal. The treatment was curative in the short period in all the @entity1 , with complete symptom remission. Only one @entity1 required retreatment after 6 months. In our series of @entity1 no major complications, e.g., @entity548 or @entity281 , were observed. In 8 cases the resection yielded enough material for histology. To conclude, this technique can be considered a valuable alternative to surgery in the treatment of @entity10545 .

title: [CT-guided percutaneous treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity10545 :: ('MESH:D010017', 'Disease') :: ['osteoid osteomas']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

answer: @entity10545 :: (MESH:D010017,Disease) :: ['osteoid osteoma']


abstract: The management of advanced inoperable @entity135 is often based on a combined chemo-radiotherapy approach. No definitive conclusions on the effectiveness of this combination can be drawn from clinical trials because these @entity5 are heterogeneous and treatment schedules vary. Many scientific trials test highly toxic combinations, whereas not only good results but also low @entity137 are mandatory in the current practice. We report the results obtained in 90 consecutive @entity1 affected with inoperable @entity135 in stages III-IV, or relapsed after surgery. Chemotherapy consisted of a @entity900 / @entity1732 induction phase, followed by weekly administrations of @entity900 simultaneous with conventional irradiation. The objective remission rates, achieved at the end of the induction chemotherapy and the simultaneous chemo-radiotherapy phases, were respectively 55.5% and 84.5%. The @entity5 disappeared in 39% of cases, by the end of the whole treatment. With the Kaplan-Meier method, 3-year overall, progression-free and relapse-free survival rates were 21.20%, 22.25% and 38.75%, respectively. The overall survival rate, calculated with the "log-rank" test according to the stage and the site of the @entity5 , exhibited no significant differences. In contrast, significant differences (p < 0.05) were demonstrated, according to treatment intent (curative radical: 26%, vs palliative: 0%) and to the achievement of an objective response at the end of induction chemotherapy--i.e., 48% 3-year survival rate, vs 7% in chemotherapy resistant @entity5 @entity1 . When limiting the analysis to 72 radically irradiated @entity1 , however, the achievement of CR after induction chemotherapy lost its prognostic value. @entity137 was not substantially higher than with conventional irradiation. Our results are in agreement with literature data on this subject which, regarding survival, fail to prove such integrated treatments as ours better than irradiation alone. In contrast, the preliminary combination of chemotherapy and irradiation is clearly better for the @entity1 waiting to receive radiation therapy, because @entity5 volume and related symptoms markedly decrease after induction chemotherapy. Currently the best survival rates (about 50% at 3 years) with chemo-radiotherapy are obtained, in this kind of @entity5 , by combining @entity900 and continuous-infusion @entity1487 , simultaneous with irradiation. However, frequent and severe @entity137 is reported. Should such a modality be adopted in the current practice, @entity1 should be selected according to their medical conditions.

title: [Combined chemo-radiotherapy in non-operable cervico-facial neoplasms. Final results of an experience with non-selected XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer', 'head and neck cancers']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'primary tumor', 'neoplasms']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cis-platinum']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: To evaluate the efficacy and safety of @entity1416 prior to @entity439 repair (EVAR). METHODS: A retrospective review was conducted of all 101 consecutive @entity1 (91 @entity1 ; mean age 73.4    8.7 years) who underwent preliminary embolization of 133 HAs    4 to 6 weeks prior to EVAR from January 2005 to August 2009. Fourteen @entity1 with 19 HAs were treated using coils, while 87 @entity1 were treated with Amplatzer Vascular Plugs (AVP) in 114 HAs. All the @entity1 were evaluated before discharge; at 1, 3, and 6 months; and annually thereafter to evaluate the clinical symptoms, potential endoleaks, and the @entity439 size. RESULTS: In the coil group, complete occlusion was achieved in 16 (84.2%) of 19 procedures. There were no acute @entity63 after @entity432 embolization or EVAR. Five (35.7%) @entity1 had buttock claudication and 2 (16.7%) of 12 @entity1 experienced new @entity323 after embolization. At a mean 42.2-month follow-up (range 14-58), 3 (21.4%) @entity1 had a type II leak via retrograde flow in the @entity432 without @entity439 growth and were under observation. In the AVP group, all 114 HAs in 87 @entity1 were successfully occluded; there was no device dislodgment or acute pelvic or limb @entity63 observed. Buttock claudication and new @entity250 developed in 12 (13.8%) @entity1 and 4 (5.1%) of 79 @entity1 after the procedure, respectively. During a mean 26.4-month follow-up (range 4-54), 2 (2.3%) @entity1 developed distal type I endoleaks after EVAR, but angiography confirmed that neither of the endoleaks was related to the vessel embolized with the AVP. Comparing the outcomes of the treatment groups, the AVP was placed with fewer @entity3816 (p = 0.013) and more complete occlusion (p = 0.01) than coil embolization. The rate of buttock claudication was lower in the AVP group (p = 0.042). CONCLUSION: @entity1416 prior to EVAR is safe and effective. In our experience, the AVP affords easier and more precise placement and provides more complete occlusion, with fewer intraoperative and postoperative @entity63 complications than coil embolization.

title: Preliminary embolization of the @entity432 to expand the applicability of XXXX repair.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction']

entities_list: @entity3816 :: ('MESH:D007431', 'Disease') :: ['intraoperative complications']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['pelvic ischemic symptoms', 'ischemia', 'ischemic']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['preliminary hypogastric artery (HA) embolization', 'Hypogastric artery embolization']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['endovascular aneurysm', 'aneurysm']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual dysfunction']

answer: @entity439 :: (MESH:D000783,Disease) :: ['endovascular aneurysm']


abstract: PURPOSE: To evaluate the efficacy and safety of @entity1416 prior to @entity439 repair (EVAR). METHODS: A retrospective review was conducted of all 101 consecutive @entity1 (91 @entity1 ; mean age 73.4    8.7 years) who underwent preliminary embolization of 133 HAs    4 to 6 weeks prior to EVAR from January 2005 to August 2009. Fourteen @entity1 with 19 HAs were treated using coils, while 87 @entity1 were treated with Amplatzer Vascular Plugs (AVP) in 114 HAs. All the @entity1 were evaluated before discharge; at 1, 3, and 6 months; and annually thereafter to evaluate the clinical symptoms, potential endoleaks, and the @entity439 size. RESULTS: In the coil group, complete occlusion was achieved in 16 (84.2%) of 19 procedures. There were no acute @entity63 after @entity432 embolization or EVAR. Five (35.7%) @entity1 had buttock claudication and 2 (16.7%) of 12 @entity1 experienced new @entity323 after embolization. At a mean 42.2-month follow-up (range 14-58), 3 (21.4%) @entity1 had a type II leak via retrograde flow in the @entity432 without @entity439 growth and were under observation. In the AVP group, all 114 HAs in 87 @entity1 were successfully occluded; there was no device dislodgment or acute pelvic or limb @entity63 observed. Buttock claudication and new @entity250 developed in 12 (13.8%) @entity1 and 4 (5.1%) of 79 @entity1 after the procedure, respectively. During a mean 26.4-month follow-up (range 4-54), 2 (2.3%) @entity1 developed distal type I endoleaks after EVAR, but angiography confirmed that neither of the endoleaks was related to the vessel embolized with the AVP. Comparing the outcomes of the treatment groups, the AVP was placed with fewer @entity3816 (p = 0.013) and more complete occlusion (p = 0.01) than coil embolization. The rate of buttock claudication was lower in the AVP group (p = 0.042). CONCLUSION: @entity1416 prior to EVAR is safe and effective. In our experience, the AVP affords easier and more precise placement and provides more complete occlusion, with fewer intraoperative and postoperative @entity63 complications than coil embolization.

title: Preliminary embolization of the XXXX to expand the applicability of @entity439 repair.

answer: @entity432 :: (MESH:D001157,Disease) :: ['hypogastric artery']


abstract: @entity455 of bone and soft tissue are relatively common @entity85 . @entity2695 is the most frequently encountered @entity75 . @entity2695 commonly involves the spine and calvaria and often has a characteristic radiographic appearance, with either coarsened trabeculae lying adjacent to the vascular channels or multifocal lytic areas creating a honeycomb pattern. Soft-tissue @entity2695 is the most frequent soft-tissue @entity5 of infancy and childhood. Radiography and computed tomography (CT) may show phleboliths in cavernous soft-tissue @entity2695 . The magnetic resonance (MR) imaging appearance, however, is often more distinctive, because fat overgrowth and @entity9155 vascular channels can be seen. Lymphangioma usually occurs in the neck and axillae of young @entity1 as a soft-tissue mass composed of large cavernous spaces and is well evaluated with CT, ultrasound, or MR imaging. @entity455 can also diffusely involve both bone and soft tissue in @entity4904 . A group of @entity146 , including @entity8146 , @entity2698 , and @entity5426 , may have a nonspecific imaging appearance; however, the vascular pattern can be recognized in some cases, allowing radiologic diagnosis. Imaging is important throughout the evaluation of @entity75 for detection, diagnosis, preoperative assessment, and treatment.

title: From the archives of the AFIP. XXXX : radiologic-pathologic correlation.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['Vascular lesions']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangioma', 'Osseous hemangioma', 'Hemangioma']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['angiomatous lesions', 'angiomatous lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['more aggressive vascular neoplasms']

entities_list: @entity2698 :: ('MESH:D006393', 'Disease') :: ['hemangiopericytoma']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['angiosarcoma']

entities_list: @entity9155 :: ('CHEBI:46670', 'Chemical') :: ['serpentine']

entities_list: @entity4904 :: ('MESH:D000798', 'Disease') :: ['angiomatosis']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal neoplasms']

entities_list: @entity8146 :: ('MESH:D006390', 'Disease') :: ['hemangioendothelioma']

answer: @entity85 :: (MESH:D009140,Disease) :: ['Musculoskeletal angiomatous lesions']


abstract: PURPOSE OF THE STUDY: @entity2950 is a frequent cause of @entity7529 . Its diagnosis is clinical but progress in medical imaging: ultrasound, evoked potentials and above all MRI allows an improvement of para-clinical diagnosis. MATERIAL AND METHODS: 48 @entity2950 were treated surgically between 1979 and 1990. That represents 46 feet in 43 @entity1 . Female predominance was clear with an average age of 53 years. The follow-up period was 6 years and 10 months. 3 @entity1 had @entity1230 . Medical treatment had been prescribed prior to surgery in 24 @entity1 (15 had injections, 9 orthopedic shoe inserts and 5 both injections and inserts). The interval between the first symptoms and surgery was long since it was on average of 3 years and 6 months. The @entity2950 was located 36 times in the third interdigital space. The initial incision was plantar 11 times dorsal 32 times. Only neurectomies were performed. The @entity2950 was very large 9 times. 10 @entity1 had treatment for other affections in the same operative time. RESULTS: At review, 41 feet were @entity1939 . Shoe wear was normal for 32 @entity1 . 12 @entity1183 and 7 commissural and @entity1183 were noted. 3 of 11 @entity1 operated by the plantar approach had a @entity158 . DISCUSSION: None of our cases had preoperative MRI because our most recent case has 4 years of evaluation. At the present time the MRI could contribute to diagnosis owing to good tissular differentiation. The neurectomy led to a total disappearance of @entity158 but @entity1183 was frequent. The dorsal approach induces cutaneous complication. Neurolysis induces a sensitive postoperative deficit but recurrence occurs in 77 per cent of cases after neurolysis. CONCLUSION: @entity2950 is located essentially in the third interdigital space. Neurectomy is a simple operation that often leads to recovery.

title: [Treatment of XXXX by neurectomy. Apropos of 43 cases].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1183 :: ('MESH:D006987', 'Disease') :: ['pulpary hypoesthesia', 'hypoesthesia', 'pulpar hypoesthesia']

entities_list: @entity7529 :: ('MESH:D037061', 'Disease') :: ['metatarsalgia']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['completely painless']

entities_list: @entity1230 :: ('MESH:D009104', 'Disease') :: ['multiple injuries']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful hyperkeratosic scar']

entities_list: @entity2950 :: ('MESH:D009463', 'Disease') :: ['neuroma', "Morton's neuroma", 'neuromas']

answer: @entity2950 :: (MESH:D009463,Disease) :: ['Morton neuroma']


abstract: The objective is to evaluate the therapeutic effect and @entity137 of IV @entity786 on the evolution of diffuse and focal proliferative forms of @entity1988 . It's a prospective, descriptive and non-controlled study. We treated 12 @entity1 (M/F = 1:11, aged 30.07 +/- 14.15) diagnosed by renal biopsy with diffuse proliferative (n = 10) and focal (n = 2) @entity1988 . All @entity1 received IV @entity786 . A dose of 1 g/sg.m of body surface area was administered monthly for the first three months and each three months until two years. The follow-up was 34 +/- 24.83 months (range 6-67). Seven @entity1 completed two years of treatment with @entity786 with a further follow-up of 18.71 +/- 12.36 months (range 6-67). Renal function either improved or remained unchanged. @entity644 , @entity811 and immunologic markers decreased or normalized at three years. The @entity1 who finished the period of two years with CFIV remained stable. There were neither infections nor @entity2335 . We conclude that with the scheme of CFIV used by us good therapeutics effects will be obtained with minimum secondary @entity137 in a follow-up of three to five years.

title: [Treatment of the diffuse and focal proliferative forms of lupus nephropathy with intravenous XXXX . Intravenous @entity786 in systemic lupus erythematosus].

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['Proteinuria']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['Cyclophosphamide']

entities_list: @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis']

entities_list: @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria']

entities_list: @entity2335 :: ('MESH:D003556', 'Disease') :: ['hemorrhagic cystitis']

answer: @entity786 :: (MESH:D003520,Chemical) :: ['cyclophosphamide']


abstract: The objective is to evaluate the therapeutic effect and @entity137 of IV @entity786 on the evolution of diffuse and focal proliferative forms of @entity1988 . It's a prospective, descriptive and non-controlled study. We treated 12 @entity1 (M/F = 1:11, aged 30.07 +/- 14.15) diagnosed by renal biopsy with diffuse proliferative (n = 10) and focal (n = 2) @entity1988 . All @entity1 received IV @entity786 . A dose of 1 g/sg.m of body surface area was administered monthly for the first three months and each three months until two years. The follow-up was 34 +/- 24.83 months (range 6-67). Seven @entity1 completed two years of treatment with @entity786 with a further follow-up of 18.71 +/- 12.36 months (range 6-67). Renal function either improved or remained unchanged. @entity644 , @entity811 and immunologic markers decreased or normalized at three years. The @entity1 who finished the period of two years with CFIV remained stable. There were neither infections nor @entity2335 . We conclude that with the scheme of CFIV used by us good therapeutics effects will be obtained with minimum secondary @entity137 in a follow-up of three to five years.

title: [Treatment of the diffuse and focal proliferative forms of lupus nephropathy with intravenous @entity786 . Intravenous XXXX in systemic lupus erythematosus].

answer: @entity786 :: (MESH:D003520,Chemical) :: ['cyclophosphamide']


abstract: UNASSIGNED: Up to 50% of @entity1 with @entity746 ( @entity746 ) show mild to moderate cognitive-behavioural change alongside their progressive functional impairment. This study examines the relative impact of @entity1 ' disease symptoms, behavioural change and current executive function and social cognition abilities on psychosocial outcomes in spouse caregivers of @entity1 with @entity746 . Thirty-five spouse caregivers rated their own levels of @entity308 and @entity148 , subjective burden and marital satisfaction. Caregivers also rated their partner's everyday behaviour. The @entity1 were assessed for disease severity and cognitive function, with composite scores derived for executive function and social cognition. Regression analyses revealed that caregiver burden was predicted by the severity of @entity1 ' limb involvement and behavioural problems. @entity308 was predicted by @entity1 ' limb involvement, while behavioural problems and @entity1 age predicted @entity148 . Current marital satisfaction was predicted by @entity1 behavioural problems beyond the level of pre-illness marital satisfaction. In conclusion, the study highlights the potential impact of @entity746 @entity1 ' functional impairment and behavioural change on @entity746 caregivers' psychosocial functioning. Clinical communication with @entity746 families should emphasise both physical and psychological challenges presented by the disease.

title: Impact of disease, cognitive and behavioural factors on caregiver outcome in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety', 'caregiver anxiety']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis']

answer: @entity746 :: (MESH:D000690,Disease) :: ['amyotrophic lateral sclerosis']


abstract: @entity1455 continues to be a clinical situation which is related with high mortality. Although its etiology is varied, the most frequent cause is an acute @entity583 . The poor prognosis of @entity1455 can be favourably modified with the diagnosis of the underlying cause followed by the stabilization of the @entity1 and early revascularization. Early treatment with inotropic or vasopressor drugs improves the condition of most @entity1 and the use of circulatory assistance, such as the intraaortic balloon, lead to an acceptable hemodynamic situation in 80% of cases. However, they do not significantly modify the mortality rates. In addition, thrombolytic therapy does not appear to be effective for this kind of @entity1 . Only revascularization methods have proved to be effective; surgery is the only option where ventricular septal, free wall, or @entity121 occurs, resulting in survival rates of between 50 and 60% with coronary artery by-pass surgery. Angioplasty is frequently successful in reperfusion of the @entity1188 ; the survival rate in these cases is approximately 70%, according to the different series published. As the mortality rate is exceedingly high (70-90%) when conventional therapy is used; when appropriate diagnostic and therapeutic means are available and when the @entity1 's condition is recoverable, the attitude should be aggressive and coronary angiography and angioplasty applied as soon as possible. In centers where these means are not available, once measures have been taken to achieve the stabilization of the @entity1 , the most suitable procedure is to transfer him or her to a hospital in which qualified staff and such treatment methods are available.

title: [Therapeutic options in XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct-related artery']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['Cardiogenic shock', 'cardiogenic shock']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['papillary muscle rupture']

answer: @entity1455 :: (MESH:D012770,Disease) :: ['cardiogenic shock']


abstract: AIM: @entity1209 ( @entity1209 ) can affect a @entity1 's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about @entity3003 -based regimens. Female sex is a known risk factor for @entity1209 . The purpose of this study was to evaluate @entity7274 plus single-dose @entity619 ( @entity9170 ) for preventing @entity1209 caused by @entity3003 plus @entity1311 combination therapy (TC regimen) in @entity1 with @entity5 . MATERIAL AND METHODS: @entity1 were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible @entity1 were @entity1 with uterine cervical, @entity43 scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 @entity1 were randomly assigned to receive @entity7274 in combination with 1-day @entity9170 or 3-day @entity9170 . RESULTS: During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of @entity1 in the 3-day @entity9170 arm, and 60.7% (95% confidence interval, 46.8-73.5) of @entity1 in the 1-day @entity9170 arm; CR was significantly lower in the 1-day @entity9170 arm if @entity11535 was already present (P   =   0.0370). In the severe @entity7494 gravidarum cohort, CR in the 1-day @entity9170 arm tended to be lower than in the 3-day @entity9170 arm. CONCLUSION: Combination therapy of @entity7274 and 1-day @entity9170 was effective for subjects undergoing a TC regimen for @entity5 . However, the possibility of reduced efficacy of 1-day only @entity9170 therapy in @entity1 undergoing a TC regimen could not be refuted and requires further investigation.

title: XXXX in combination with 1-day versus 3-day @entity619 for prevention of @entity1209 following @entity1311 and @entity3003 in @entity1 with @entity5 : A randomized, multicenter, phase-II trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['endometrial or ovarian cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['gynecologic cancers']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity7494 :: ('MESH:D006939', 'Disease') :: ['hyperemesis']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity11535 :: ('MESH:D009041', 'Disease') :: ['motion sickness']

entities_list: @entity7274 :: ('MESH:C083418', 'Chemical') :: ['palonosetron']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['CINV', 'Chemotherapy-induced nausea and vomiting']

answer: @entity7274 :: (MESH:C083418,Chemical) :: ['Palonosetron']


abstract: AIM: @entity1209 ( @entity1209 ) can affect a @entity1 's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about @entity3003 -based regimens. Female sex is a known risk factor for @entity1209 . The purpose of this study was to evaluate @entity7274 plus single-dose @entity619 ( @entity9170 ) for preventing @entity1209 caused by @entity3003 plus @entity1311 combination therapy (TC regimen) in @entity1 with @entity5 . MATERIAL AND METHODS: @entity1 were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible @entity1 were @entity1 with uterine cervical, @entity43 scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 @entity1 were randomly assigned to receive @entity7274 in combination with 1-day @entity9170 or 3-day @entity9170 . RESULTS: During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of @entity1 in the 3-day @entity9170 arm, and 60.7% (95% confidence interval, 46.8-73.5) of @entity1 in the 1-day @entity9170 arm; CR was significantly lower in the 1-day @entity9170 arm if @entity11535 was already present (P   =   0.0370). In the severe @entity7494 gravidarum cohort, CR in the 1-day @entity9170 arm tended to be lower than in the 3-day @entity9170 arm. CONCLUSION: Combination therapy of @entity7274 and 1-day @entity9170 was effective for subjects undergoing a TC regimen for @entity5 . However, the possibility of reduced efficacy of 1-day only @entity9170 therapy in @entity1 undergoing a TC regimen could not be refuted and requires further investigation.

title: @entity7274 in combination with 1-day versus 3-day @entity619 for prevention of @entity1209 following XXXX and @entity3003 in @entity1 with @entity5 : A randomized, multicenter, phase-II trial.

answer: @entity1311 :: (MESH:D017239,Chemical) :: ['paclitaxel']


abstract: AIM: @entity1209 ( @entity1209 ) can affect a @entity1 's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about @entity3003 -based regimens. Female sex is a known risk factor for @entity1209 . The purpose of this study was to evaluate @entity7274 plus single-dose @entity619 ( @entity9170 ) for preventing @entity1209 caused by @entity3003 plus @entity1311 combination therapy (TC regimen) in @entity1 with @entity5 . MATERIAL AND METHODS: @entity1 were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible @entity1 were @entity1 with uterine cervical, @entity43 scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 @entity1 were randomly assigned to receive @entity7274 in combination with 1-day @entity9170 or 3-day @entity9170 . RESULTS: During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of @entity1 in the 3-day @entity9170 arm, and 60.7% (95% confidence interval, 46.8-73.5) of @entity1 in the 1-day @entity9170 arm; CR was significantly lower in the 1-day @entity9170 arm if @entity11535 was already present (P   =   0.0370). In the severe @entity7494 gravidarum cohort, CR in the 1-day @entity9170 arm tended to be lower than in the 3-day @entity9170 arm. CONCLUSION: Combination therapy of @entity7274 and 1-day @entity9170 was effective for subjects undergoing a TC regimen for @entity5 . However, the possibility of reduced efficacy of 1-day only @entity9170 therapy in @entity1 undergoing a TC regimen could not be refuted and requires further investigation.

title: @entity7274 in combination with 1-day versus 3-day XXXX for prevention of @entity1209 following @entity1311 and @entity3003 in @entity1 with @entity5 : A randomized, multicenter, phase-II trial.

answer: @entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']


abstract: AIM: @entity1209 ( @entity1209 ) can affect a @entity1 's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about @entity3003 -based regimens. Female sex is a known risk factor for @entity1209 . The purpose of this study was to evaluate @entity7274 plus single-dose @entity619 ( @entity9170 ) for preventing @entity1209 caused by @entity3003 plus @entity1311 combination therapy (TC regimen) in @entity1 with @entity5 . MATERIAL AND METHODS: @entity1 were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible @entity1 were @entity1 with uterine cervical, @entity43 scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 @entity1 were randomly assigned to receive @entity7274 in combination with 1-day @entity9170 or 3-day @entity9170 . RESULTS: During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of @entity1 in the 3-day @entity9170 arm, and 60.7% (95% confidence interval, 46.8-73.5) of @entity1 in the 1-day @entity9170 arm; CR was significantly lower in the 1-day @entity9170 arm if @entity11535 was already present (P   =   0.0370). In the severe @entity7494 gravidarum cohort, CR in the 1-day @entity9170 arm tended to be lower than in the 3-day @entity9170 arm. CONCLUSION: Combination therapy of @entity7274 and 1-day @entity9170 was effective for subjects undergoing a TC regimen for @entity5 . However, the possibility of reduced efficacy of 1-day only @entity9170 therapy in @entity1 undergoing a TC regimen could not be refuted and requires further investigation.

title: @entity7274 in combination with 1-day versus 3-day @entity619 for prevention of @entity1209 following @entity1311 and XXXX in @entity1 with @entity5 : A randomized, multicenter, phase-II trial.

answer: @entity3003 :: (MESH:D016190,Chemical) :: ['carboplatin']


abstract: AIM: @entity1209 ( @entity1209 ) can affect a @entity1 's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about @entity3003 -based regimens. Female sex is a known risk factor for @entity1209 . The purpose of this study was to evaluate @entity7274 plus single-dose @entity619 ( @entity9170 ) for preventing @entity1209 caused by @entity3003 plus @entity1311 combination therapy (TC regimen) in @entity1 with @entity5 . MATERIAL AND METHODS: @entity1 were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible @entity1 were @entity1 with uterine cervical, @entity43 scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 @entity1 were randomly assigned to receive @entity7274 in combination with 1-day @entity9170 or 3-day @entity9170 . RESULTS: During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of @entity1 in the 3-day @entity9170 arm, and 60.7% (95% confidence interval, 46.8-73.5) of @entity1 in the 1-day @entity9170 arm; CR was significantly lower in the 1-day @entity9170 arm if @entity11535 was already present (P   =   0.0370). In the severe @entity7494 gravidarum cohort, CR in the 1-day @entity9170 arm tended to be lower than in the 3-day @entity9170 arm. CONCLUSION: Combination therapy of @entity7274 and 1-day @entity9170 was effective for subjects undergoing a TC regimen for @entity5 . However, the possibility of reduced efficacy of 1-day only @entity9170 therapy in @entity1 undergoing a TC regimen could not be refuted and requires further investigation.

title: @entity7274 in combination with 1-day versus 3-day @entity619 for prevention of @entity1209 following @entity1311 and @entity3003 in @entity1 with XXXX : A randomized, multicenter, phase-II trial.

answer: @entity5 :: (MESH:D009369,Disease) :: ['gynecologic cancers']


abstract: AIM: @entity1209 ( @entity1209 ) can affect a @entity1 's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about @entity3003 -based regimens. Female sex is a known risk factor for @entity1209 . The purpose of this study was to evaluate @entity7274 plus single-dose @entity619 ( @entity9170 ) for preventing @entity1209 caused by @entity3003 plus @entity1311 combination therapy (TC regimen) in @entity1 with @entity5 . MATERIAL AND METHODS: @entity1 were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible @entity1 were @entity1 with uterine cervical, @entity43 scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 @entity1 were randomly assigned to receive @entity7274 in combination with 1-day @entity9170 or 3-day @entity9170 . RESULTS: During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of @entity1 in the 3-day @entity9170 arm, and 60.7% (95% confidence interval, 46.8-73.5) of @entity1 in the 1-day @entity9170 arm; CR was significantly lower in the 1-day @entity9170 arm if @entity11535 was already present (P   =   0.0370). In the severe @entity7494 gravidarum cohort, CR in the 1-day @entity9170 arm tended to be lower than in the 3-day @entity9170 arm. CONCLUSION: Combination therapy of @entity7274 and 1-day @entity9170 was effective for subjects undergoing a TC regimen for @entity5 . However, the possibility of reduced efficacy of 1-day only @entity9170 therapy in @entity1 undergoing a TC regimen could not be refuted and requires further investigation.

title: @entity7274 in combination with 1-day versus 3-day @entity619 for prevention of XXXX following @entity1311 and @entity3003 in @entity1 with @entity5 : A randomized, multicenter, phase-II trial.

answer: @entity1209 :: (MESH:D020250,Disease) :: ['nausea and vomiting']


abstract: AIM: @entity1209 ( @entity1209 ) can affect a @entity1 's quality of life, leading to poor compliance with further treatments. Previous studies have provided minimal data about @entity3003 -based regimens. Female sex is a known risk factor for @entity1209 . The purpose of this study was to evaluate @entity7274 plus single-dose @entity619 ( @entity9170 ) for preventing @entity1209 caused by @entity3003 plus @entity1311 combination therapy (TC regimen) in @entity1 with @entity5 . MATERIAL AND METHODS: @entity1 were recruited for this phase-II, multicenter, randomized trial from 12 hospitals in Hokkaido, Japan. Eligible @entity1 were @entity1 with uterine cervical, @entity43 scheduled to receive conventional TC regimen or dose-dense TC regimen; 116 @entity1 were randomly assigned to receive @entity7274 in combination with 1-day @entity9170 or 3-day @entity9170 . RESULTS: During the overall period, complete response (CR) was observed in 67.9% (95% confidence interval, 53.7-80.1) of @entity1 in the 3-day @entity9170 arm, and 60.7% (95% confidence interval, 46.8-73.5) of @entity1 in the 1-day @entity9170 arm; CR was significantly lower in the 1-day @entity9170 arm if @entity11535 was already present (P   =   0.0370). In the severe @entity7494 gravidarum cohort, CR in the 1-day @entity9170 arm tended to be lower than in the 3-day @entity9170 arm. CONCLUSION: Combination therapy of @entity7274 and 1-day @entity9170 was effective for subjects undergoing a TC regimen for @entity5 . However, the possibility of reduced efficacy of 1-day only @entity9170 therapy in @entity1 undergoing a TC regimen could not be refuted and requires further investigation.

title: @entity7274 in combination with 1-day versus 3-day @entity619 for prevention of @entity1209 following @entity1311 and @entity3003 in XXXX with @entity5 : A randomized, multicenter, phase-II trial.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Systemic corticosteroids have been traditionally used in the therapy of @entity4816 in @entity1 with @entity1252 . The high morbidity associated with long-term corticosteroid therapy has prompted the use of corticosteroid-sparing strategies with cytotoxic agents. METHODS: This retrospective study summarizes the authors' experience of the last 10 years including 9 @entity1252 @entity1 with @entity4816 who required treatment for longer than 6 months. RESULTS: Seven of these @entity1 were treated with cytotoxic agents. Average follow-up was 39 months. @entity32 was controlled clinically and angiographically in all @entity1 using the following therapeutic regimens: systemic @entity288 and @entity6383 (n = 1 @entity1 ); systemic corticosteroids and cytotoxic chemotherapy (n = 6); cytotoxic chemotherapy and @entity6383 (n = 1); and @entity6383 alone (n = 1). Visual acuity was preserved (> 20/30) or improved in all @entity1 . All @entity1 retained excellent control of their @entity262 during their follow-up. Side effects of cytotoxic drugs requiring discontinuation of all chemotherapy were not encountered in this group; @entity500 therapy did result in substantial adverse effects necessitating its replacement with other drugs. CONCLUSION: These results suggest a valuable role for corticosteroid-sparing drugs in the therapy of @entity4816 associated with @entity1252 .

title: Corticosteroid-sparing strategies in the treatment of @entity4816 in XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['systemic lupus erythematosus']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity6383 :: ('MESH:D006886', 'Chemical') :: ['hydroxychloroquine']

entities_list: @entity4816 :: ('MESH:D031300', 'Disease') :: ['retinal vasculitis']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']


abstract: BACKGROUND: Systemic corticosteroids have been traditionally used in the therapy of @entity4816 in @entity1 with @entity1252 . The high morbidity associated with long-term corticosteroid therapy has prompted the use of corticosteroid-sparing strategies with cytotoxic agents. METHODS: This retrospective study summarizes the authors' experience of the last 10 years including 9 @entity1252 @entity1 with @entity4816 who required treatment for longer than 6 months. RESULTS: Seven of these @entity1 were treated with cytotoxic agents. Average follow-up was 39 months. @entity32 was controlled clinically and angiographically in all @entity1 using the following therapeutic regimens: systemic @entity288 and @entity6383 (n = 1 @entity1 ); systemic corticosteroids and cytotoxic chemotherapy (n = 6); cytotoxic chemotherapy and @entity6383 (n = 1); and @entity6383 alone (n = 1). Visual acuity was preserved (> 20/30) or improved in all @entity1 . All @entity1 retained excellent control of their @entity262 during their follow-up. Side effects of cytotoxic drugs requiring discontinuation of all chemotherapy were not encountered in this group; @entity500 therapy did result in substantial adverse effects necessitating its replacement with other drugs. CONCLUSION: These results suggest a valuable role for corticosteroid-sparing drugs in the therapy of @entity4816 associated with @entity1252 .

title: Corticosteroid-sparing strategies in the treatment of XXXX in @entity1252 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity4816 :: (MESH:D031300,Disease) :: ['retinal vasculitis']


abstract: OBJECTIVES: @entity626 ( @entity571 ) is pervasive in aged populations, and induces considerable socioeconomic expense. The objective of this study was to investigate the association between @entity571 prevalence and pregnancy and parity in Koreans, considering for the potential effect of abortion. STUDY DESIGN: A total 5449 @entity1 aged >= 50 years with radiological knee examination results of 24,173 @entity1 of the 5th Korean National Health and Nutrition Examination Survey (2010-2012) were analyzed in a cross-sectional study. MAIN OUTCOME MEASURES: Association between @entity571 prevalence (Kellgren/Lawrence grade) and pregnancy and parity as odds ratios (ORs) by logistic regression. RESULTS: Knee @entity571 results were normal in 1996 @entity1 (36.1%), suspected in 1012 (18.6%), mild in 781 (14.3%), moderate in 1073 (19.7%), and severe in 617 (11.3%). Increase in number of pregnancies adjusted for abortion was significantly associated with increased @entity571 prevalence (OR 1.081; 95% CI 1.015, 1.152). @entity571 prevalence increased with parity (continuous variable) in ever-abortion (OR 1.092; 95% CI 1.009, 1.181) and with parity (categorical variable) with reference value set at 1-2 (P for trend; p=0.0195). In analyses adjusted for abortion, ever-abortion negatively influenced @entity571 prevalence. Parity was not associated with @entity571 in number of pregnancies unadjusted for abortion or in never-abortion @entity1 . CONCLUSIONS: This study shows that maternity-related factors such as pregnancy and parity were related with knee @entity571 prevalence in this population-based sample of older @entity1 , and that relationships with abortion were stronger.

title: Influence of parity-related factors adjusted for abortion on XXXX in Korean @entity1 aged 50 or older: A cross-sectional study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['Knee osteoarthritis']

answer: @entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']


abstract: OBJECTIVES: @entity626 ( @entity571 ) is pervasive in aged populations, and induces considerable socioeconomic expense. The objective of this study was to investigate the association between @entity571 prevalence and pregnancy and parity in Koreans, considering for the potential effect of abortion. STUDY DESIGN: A total 5449 @entity1 aged >= 50 years with radiological knee examination results of 24,173 @entity1 of the 5th Korean National Health and Nutrition Examination Survey (2010-2012) were analyzed in a cross-sectional study. MAIN OUTCOME MEASURES: Association between @entity571 prevalence (Kellgren/Lawrence grade) and pregnancy and parity as odds ratios (ORs) by logistic regression. RESULTS: Knee @entity571 results were normal in 1996 @entity1 (36.1%), suspected in 1012 (18.6%), mild in 781 (14.3%), moderate in 1073 (19.7%), and severe in 617 (11.3%). Increase in number of pregnancies adjusted for abortion was significantly associated with increased @entity571 prevalence (OR 1.081; 95% CI 1.015, 1.152). @entity571 prevalence increased with parity (continuous variable) in ever-abortion (OR 1.092; 95% CI 1.009, 1.181) and with parity (categorical variable) with reference value set at 1-2 (P for trend; p=0.0195). In analyses adjusted for abortion, ever-abortion negatively influenced @entity571 prevalence. Parity was not associated with @entity571 in number of pregnancies unadjusted for abortion or in never-abortion @entity1 . CONCLUSIONS: This study shows that maternity-related factors such as pregnancy and parity were related with knee @entity571 prevalence in this population-based sample of older @entity1 , and that relationships with abortion were stronger.

title: Influence of parity-related factors adjusted for abortion on @entity626 in Korean XXXX aged 50 or older: A cross-sectional study.

answer: @entity1 :: (9606,Species) :: ['women']


abstract: OBJECTIVES: The objective was to describe the @entity341 ( @entity341 ) resource burden of the spring 2009 H1N1 influenza pandemic at U.S. @entity1 's hospitals by quantifying observed-to-expected utilization. METHODS: The authors performed an ecologic analysis for April through July 2009 using data from 23 @entity26144 in the Pediatric Health Information System (PHIS), an administrative database of widely distributed U.S. @entity1 's hospitals. All @entity341 visits during the study period were included, and data from the 5 prior years were used for establishing expected values. Primary outcome measures included observed-to-expected ratios for @entity341 visits for all reasons and for @entity683 ( @entity683 ). RESULTS: Overall, 390,983 visits, and 88,885 visits for @entity683 , were included for Calendar Weeks 16 through 29, when 2009 H1N1 influenza was circulating. The subset of 106,330 visits and 31,703 @entity683 visits made to the 14 hospitals experiencing the authors' definition of @entity341 surge during Weeks 16 to 29 was also studied. During surge weeks, the 14 @entity26144 experienced 29% more total visits and 51% more @entity683 visits than expected (p < 0.01 for both comparisons). Of @entity683 during surge weeks, only 4.8% were admitted to non-intensive care beds (70% of expected, p < 0.01), 0.19% were admitted to intensive care units (44% of expected, p < 0.01), and 0.01% received mechanical ventilation (5.0% of expected, p < 0.01). Factors associated with more-than-expected visits included ages 2-17 years, payer type, and @entity565 . No factors were associated with more-than-expected hospitalizations from the @entity341 . CONCLUSIONS: During the spring 2009 H1N1 influenza pandemic, pediatric @entity26144 nationwide experienced a marked @entity101 , with far fewer than expected requiring nonintensive or intensive care hospitalization. The data in this study can be used for future pandemic planning.

title: Resource burden at XXXX 's hospitals experiencing surge volumes during the spring 2009 H1N1 influenza pandemic.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['increase in visits']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza-related illness', 'IRI', 'ED IRI visits']

answer: @entity1 :: (9606,Species) :: ['children']