abstract: PURPOSE: @entity2342 ( @entity2342 ) are common symptoms in @entity1 with @entity5 that may interfere with nutritional intake and quality of life. In this study, we explore and describe how characteristics of self-reported @entity2342 change in individuals with @entity2 over time using a multiple case study approach to present longitudinal data from individuals. METHODS: @entity1 under investigation for @entity2 were recruited from one university hospital in Sweden. The 52 @entity1 providing data eligible for the analyses presented here were those treated for primary @entity2 with three measurement time-points, of which one was prior to treatment and two after treatment start. Four self-report instruments were used for data collection. These included the Taste and Smell Survey, used to characterize @entity2342 for each individual at the three time-points and instruments measuring nutritional status, symptom burden and well-being. Three @entity1 cases are described in detail to illustrate variation in individual experiences of @entity2342 . RESULTS: The characteristics of the @entity2342 experienced changed over time for many of the individuals in this study, including those undergoing surgery or stereotactic radiotherapy. The case descriptions show how the individual experiences of @entity2342 and the impact on daily life of these symptoms not only depend on @entity10319 characteristics, but may be influenced by contextual factors, e.g. other symptoms and life situation. CONCLUSIONS: Our results suggest that healthcare professionals need to consider the variation in characteristics of @entity2342 among and within @entity1 over time, and be attentive to individual experiences of @entity2342 .

title: A longitudinal study of changing characteristics of self-reported taste and smell alterations in @entity1 treated for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity2342 :: ('MESH:D004408', 'Disease') :: ['Taste and smell alterations', 'TSAs']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: PURPOSE: @entity2342 ( @entity2342 ) are common symptoms in @entity1 with @entity5 that may interfere with nutritional intake and quality of life. In this study, we explore and describe how characteristics of self-reported @entity2342 change in individuals with @entity2 over time using a multiple case study approach to present longitudinal data from individuals. METHODS: @entity1 under investigation for @entity2 were recruited from one university hospital in Sweden. The 52 @entity1 providing data eligible for the analyses presented here were those treated for primary @entity2 with three measurement time-points, of which one was prior to treatment and two after treatment start. Four self-report instruments were used for data collection. These included the Taste and Smell Survey, used to characterize @entity2342 for each individual at the three time-points and instruments measuring nutritional status, symptom burden and well-being. Three @entity1 cases are described in detail to illustrate variation in individual experiences of @entity2342 . RESULTS: The characteristics of the @entity2342 experienced changed over time for many of the individuals in this study, including those undergoing surgery or stereotactic radiotherapy. The case descriptions show how the individual experiences of @entity2342 and the impact on daily life of these symptoms not only depend on @entity10319 characteristics, but may be influenced by contextual factors, e.g. other symptoms and life situation. CONCLUSIONS: Our results suggest that healthcare professionals need to consider the variation in characteristics of @entity2342 among and within @entity1 over time, and be attentive to individual experiences of @entity2342 .

title: A longitudinal study of changing characteristics of self-reported taste and smell alterations in XXXX treated for @entity2 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: A new transtelephonic monitoring device designed for use with @entity737 ( @entity737 ) was evaluated. It is capable of interrogating @entity737 and transmitting the following data via telephone: programmed parameters (e.g., @entity1165 [ @entity1165 ] and @entity2224 [ @entity2224 ] detection, therapies), number of @entity1165 and @entity2224 episodes, identification of successful therapies, the 20 cycle lengths preceding the last episode detected, the 10 cycle lengths after the last delivered therapy, battery voltage, and real-time transmission of the @entity1 's rhythm. Eighteen @entity1 (mean age 64 +/- 17 years; 15 males) were implanted with an @entity1479 and epicardial lead system. The @entity1 who did not live near the primary hospital were provided with this transmitter and instructed to transmit monthly and whenever @entity1163 , @entity1163 , or a shock were experienced. Five hundred ten episodes of spontaneous @entity943 (495 @entity1165 , 15 @entity2224 ) were detected in 14 of 18 @entity1 in a 24-month period and the success of each therapy (antitachycardia pacing, cardioversion 0.4-34 J, defibrillation 34 J) was analyzed. The number of therapies delivered and their success (%) in terminating the @entity943 were: 380 ramp/86%, 116 burst/84%, 119 cardioversion/57%, and 15 defibrillations/100%. Sixty-three (42%) of the 152 transmissions indicated an @entity943 . Twenty-five (16%) of the 152 were transmitted because of symptoms. Sixteen (9.7%) of 165 @entity1165 episodes could not be terminated by the full set of programmed @entity1165 therapies. Analysis of the pre- and post-episode intervals along with the @entity1 's transmitted rhythm indicated that @entity7129 or @entity955 were likely responsible for these episodes.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Transtelephonic monitoring and transmission of stored XXXX detection and therapy data from an implantable cardioverter defibrillator.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia']

entities_list: @entity1163 :: ('MESH:D013575', 'Disease') :: ['syncope', 'presyncope']

entities_list: @entity737 :: ('MESH:D057873', 'Disease') :: ['ICDs', 'implantable cardioverter defibrillators']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['VF', 'ventricular fibrillation']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity7129 :: ('MESH:D013616', 'Disease') :: ['sinus tachycardia']

answer: @entity943 :: (MESH:D001145,Disease) :: ['arrhythmia']


abstract: The aim of the study has to be find, on basis of long term follow-up, an independent factors determining of pacemaker implantation in @entity1 with @entity1817 . The second point was to find an independent risk factors of @entity64 and another serious complication in this group of @entity1 (specially in paced group). The study group consisted 169 pts with @entity1817 (in all pts abnormal electrophysiological tests--transoesophageal atrial stimulation). The form of @entity1817 (extrinsic or intrinsic) was determined on basis of electrophysiological study after pharmacological denervation of the heart ( @entity1169 and @entity3897 i.v. in doses 0.2 and 0.04 mg/kg body weight respectively). The statistical analysis was performed on all pts (97 @entity1 and 72 @entity1 48 +/- 16 yrs old) using Cox's model of proportional hazardous analysing. The follow-up period ranging from 14 to 84 months (mean 49.9 +/- 19). Pacemaker was implanted in 88 pts during observation period. @entity64 signs were found in 7 pts including 6 pts after pacemaker implantation. There was 13 death (7 sudden or primary @entity16 ). CONCLUSIONS: 1) independent factors of pacemaker implantation were @entity1163 , age and persistent @entity1168 , 2) form of @entity1817 was not an independent factor of this decision, 3) age (older), persistent after pacemaker implantation @entity1163 and registered in transesophageal ecg ventriculo-atrial condition were independent risk factors of @entity64 in pts with VVI stimulation, 4) despite of pacemaker implantation (VVI mode) many @entity1 have @entity1163 or @entity1163 attacks but life comfort in this group was much better then before implantation.

title: [ XXXX (extrinsic and intrinsic form) during long term observation].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological death']

entities_list: @entity1163 :: ('MESH:D013575', 'Disease') :: ['presyncopal', 'syncope']

entities_list: @entity1817 :: ('MESH:D012804', 'Disease') :: ['sick sinus syndrome', 'sinus node dysfunction', 'intrinsic and extrinsic form of sick sinus syndrome']

entities_list: @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

answer: @entity1817 :: (MESH:D012804,Disease) :: ['Sick sinus syndrome']


abstract: PURPOSE: This study aimed to evaluate racial/ethnic differences in @entity2 incidence and mortality in the @entity1 's Health Initiative Study, a longitudinal prospective cohort evaluation of postmenopausal @entity1 recruited from 40 clinical centers. METHODS: @entity2 diagnoses were centrally adjudicated by pathology review. Baseline survey questionnaires collected sociodemographic and health information. Logistic regression models estimated incidence and mortality odds by race/ethnicity adjusted for age, education, @entity460 / @entity560 , body mass index, smoking (status, age at start, duration, and pack-years), @entity285 , family history, oral contraceptive, hormones, physical activity, and diet. RESULTS: The cohort included 129,951 @entity1 -108,487 (83%) non-Hispanic white (NHW); 10,892 (8%) @entity7864 ( @entity7864 ); 4,882 (4%) Hispanic; 3,696 (3%) Asian/Pacific Islander (API); 534 (< 1%) American Indian/Alaskan Native; and 1,994 (1%) other. In unadjusted models, Hispanics had 66% lower odds of @entity2 compared with NHW (odds ratio [OR], 0.34; 95% CI, 0.2 to 0.5), followed by API (OR, 0.45; 95% CI, 0.27 to 0.75) and @entity7864 (OR, 0.75; 95% CI, 0.59 to 0.95). In fully adjusted multivariable models, the @entity2 risk for Hispanic compared with NHW @entity1 attenuated to the null (OR, 0.59; 95% CI, 0.35 to 0.99). In unadjusted models Hispanic and API @entity1 had decreased risk of @entity204 compared with NHW @entity1 (OR, 0.30 [95% CI, 0.15 to 0.62] and 0.34 [95% CI, 0.16 to 0.75, respectively); however, no racial/ethnic differences were found in risk of @entity2 @entity204 in fully adjusted models. CONCLUSION: Differences in @entity2 incidence and mortality are associated with sociodemographic, clinical, and behavioral factors. These findings suggest modifiable exposures and behaviors may contribute to differences in incidence of and mortality by race/ethnicity for postmenopausal @entity1 . Interventions focused on these factors may reduce racial/ethnic differences in @entity2 incidence and mortality.

title: Racial and Ethnic Variations in Lung Cancer Incidence and Mortality: Results From the XXXX 's Health Initiative.

entities_list: @entity7864 :: ('MESH:D055008', 'Disease') :: ['non-Hispanic black', 'NHB']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'lung cancer', 'decreased lung cancer']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: In 96 cases of @entity8942 , results of chronic pharmacological assessment (CPA) were compared with acute electrophysiological-pharmacologic assessments ( @entity8393 ) to evaluate the usefulness of @entity8393 . I. @entity1 with sustained VT (31 cases): Sustained VT and repetitive ventricular response (RVR) could be induced in 61% and 23% respectively. More than one effective drug was found by @entity8393 for 23 of 24 subjects. Of the 22 followed by CPA, the effectiveness of medication was excellent for 14 (64%), moderate for 1, slight for 4, and ineffective for 3 (14%). II. @entity1 with @entity3257 (23 cases): RVR could be induced in 52%. Effective medication was identified by @entity8393 for 8 of 10 @entity1 . Of the 7 followed by CPA, the effectiveness of medication was excellent for 2(28.5%) moderate for 2, and ineffective for 3. III. @entity1 with PSVT (42 cases): PSVT could be induced in 90% of cases. Effective medication was found for all 31 cases which underwent @entity8393 . Of the 23 cases followed by CPA, the chronic efficacy of drugs was excellent for 7 (30%), moderate for 5 (22%), slight for 7 (30%), and noneffective for 4 (18%). Therefore, we conclude that the usefulness of @entity8393 differs according to the type of @entity591 . @entity8393 is most useful in predicting chronic results for @entity1 with sustained VT, especially when the sustained VT is readily reproducible by electrical stimulation. It is less useful for nonsustained VT and PSVT. With nonsustained VT, @entity8393 is limited by difficulty in repeatedly inducing RVR, and by difficulty in predicting the appropriate medication for chronic oral therapy. With PSVT, even though the PSVT can be induced with greater success, @entity8393 is limited by variations in pharmacologic effects over time, which create discrepancies between @entity8393 and CPA.

title: The usefulness of electrophysiological-pharmacologic studies in the long-term therapy of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8942 :: ('MESH:D013614', 'Disease') :: ['paroxysmal tachycardia']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity3257 :: ('MESH:C580335', 'Disease') :: ['non-sustained VT']

answer: @entity8942 :: (MESH:D013614,Disease) :: ['paroxysmal tachycardias']


abstract: PRINCIPLES: Therapeutic target serum concentrations of first-line antituberculosis drugs have not been well defined in clinical studies in @entity378 ( @entity378 ) @entity1 . METHODS: We retrospectively investigated the estimated maximum serum concentrations (eCmax) of antituberculosis drugs and clinical outcome of @entity378 @entity1 with therapeutic drug monitoring performed between 2010-2012 at our institution, and follow-up until March 2014. The eCmax was defined as the highest serum concentration during a sampling period (2, 4 and 6 hours after drug ingestion). We compared the results with published eCmax values, and categorised them as either "within reference range", "low eCmax", or "very low eCmax".Low/very low eCmax-levels were defined as follows: @entity3109 2-3/<2 mg/l, @entity1215 4-8/<4 mg/l, @entity17208 0.2-0.3/<0.2 mg/l, @entity3110 1-2/<0.1 mg/l and @entity5585 <20 mg/l. RESULTS: Concentrations of antituberculosis drugs in 175 serum samples of 17 @entity1 with @entity378 were analysed. In 12 (71%) @entity1 , multiple therapeutic drug monitoring samples were collected over time, in 5 (29%) @entity1 only one sample was available for therapeutic drug monitoring. Overall, 94% of all @entity1 had at least one low antituberculosis drug concentration. Overall, 64% of all eCmax levels were classified as "low" or "very low". The eCmax was below the relelvant reference range in 80% of @entity3109 , 95% of @entity1215 , 30% of @entity5585 , and 30% of @entity3110 measurements. All but one @entity1 were cured of @entity378 . CONCLUSIONS: Although many antituberculosis drug serum concentrations were below the widely used reference ranges, 16 of 17 @entity1 were cured of @entity378 . These results challenge the use of the published reference ranges for therapeutic drug monitoring.

title: Cure of XXXX despite serum concentrations of antituberculosis drugs below published reference ranges.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3110 :: ('MESH:D004977', 'Chemical') :: ['ethambutol']

entities_list: @entity5585 :: ('MESH:D011718', 'Chemical') :: ['pyrazinamide']

entities_list: @entity17208 :: ('MESH:D017828', 'Chemical') :: ['rifabutin']

entities_list: @entity3109 :: ('MESH:D007538', 'Chemical') :: ['isoniazid']

entities_list: @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['TB', 'tuberculosis']

answer: @entity378 :: (MESH:D014376,Disease) :: ['tuberculosis']


abstract: Greater understanding of the underlying pathophysiology of @entity583 ( @entity583 ) has led to more aggressive management and lower mortality, both in-hospital and long term. @entity583 results mainly from @entity715 of the @entity1188 -related coronary artery. The ensuing @entity39 evolves over a 6-12 h period providing a time window for interventions designed to reduce eventual @entity1188 size. The most appropriate interventions are those which restore coronary artery patency and hence myocardial blood flow as soon as possible. Occasionally, disruption of the occluding thrombus and compression of the underlying @entity75 is best achieved by direct percutaneous transluminal coronary angioplasty. For the vast majority however, revascularisation by drug therapy is more appropriate. As soon as possible, all @entity1 without contraindications should be offered oral @entity117 and intravenous thrombolysis, usually with streptokinase but occasionally with tissue plasminogen activator. @entity1 in whom these agents are contraindicated should be considered for intravenous beta-blockade using @entity2165 or @entity1406 to reduce myocardial demand and hence @entity1188 size. @entity1 with large @entity1188 , @entity67 , @entity1002 or @entity101 should be considered for early @entity1289 inhibitor therapy. Other agents may be valuable symptomatically, but have no proven role in reducing @entity1188 size or mortality. After the first 24 h, the main aims of management are to assess the likelihood of later ischaemic events or @entity204 (risk stratification) and hence to choose appropriate long term secondary prophylaxis.

title: The management of XXXX .

entities_list: @entity1289 :: ('1636', 'Gene') :: ['angiotensin-converting enzyme']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['atheromatous lesion']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity1406 :: ('MESH:D008790', 'Chemical') :: ['metoprolol']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts', 'infarct']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'acute myocardial infarction']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['impaired ventricular function']

entities_list: @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic occlusion']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['left ventricular failure']

answer: @entity583 :: (MESH:D009203,Disease) :: ['acute myocardial infarction']


abstract: UNASSIGNED: On September 30th, 2014, the Centers for Disease Control and Prevention (CDC) confirmed the first travel-associated case of US Ebola in Dallas, TX. This case exposed two of the greatest concerns in @entity1 safety in the US outpatient health care system: misdiagnosis and ineffective use of electronic health records (EHRs). The case received widespread media attention highlighting failures in disaster management, @entity166 control, national security, and @entity341 ( @entity341 ) care. In addition, an error in making a correct and timely Ebola diagnosis on initial @entity341 presentation brought diagnostic decision-making vulnerabilities in the EHR era into the public eye. In this paper, we use this defining "teachable moment" to highlight the public health challenge of diagnostic errors and discuss the effective use of EHRs in the diagnostic process. We analyze the case to discuss several missed opportunities and outline key challenges and opportunities facing diagnostic decision-making in EHR-enabled health care. It is important to recognize the reality that EHRs suffer from major usability and inter-operability issues, but also to acknowledge that they are only tools and not a replacement for basic history-taking, examination skills, and critical thinking. While physicians and health care organizations ultimately need to own the responsibility for addressing diagnostic errors, several national-level initiatives can help, including working with software developers to improve EHR usability. Multifaceted approaches that account for both technical and non-technical factors will be needed. Ebola US @entity1 Zero reminds us that in certain cases, a single misdiagnosis can have widespread and costly implications for public health.

title: Ebola US XXXX Zero: lessons on misdiagnosis and effective use of electronic health records.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'Patient']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: OBJECTIVE: We previously reported the interim effects in a per protocol analysis of a randomized controlled trial of an innovative neuroscience-informed computerized cognitive training approach in @entity161 . Here we report the effects of training on behavioral outcome measures in our final sample using an intent-to-treat analysis. We also report the effects on serum @entity2252 ( @entity2252 ). METHOD: Eighty-seven clinically stable @entity1 with @entity161 were randomly assigned to either targeted @entity2167 ( @entity2167 , N=46) or a computer games control condition (CG, N=41). @entity1 were assessed on neurocognition, symptoms and functional outcome at baseline and after 50 hours of intervention delivered over 10 weeks. Serum @entity2252 was assessed at baseline, at 2 weeks, and at 10 weeks. RESULTS: After the intervention, @entity2167 @entity1 showed significant @entity73 , speed of processing, verbal learning, and verbal memory, relative to CG @entity1 , with no changes in symptoms or functioning. At baseline, @entity161 @entity1 had significantly lower-than-normal serum @entity2252 . @entity2167 @entity1 showed a significant increase in serum @entity2252 compared to CG @entity1 , and "normalized" levels by post training. CONCLUSIONS: @entity1 with chronic @entity161 made significant @entity73 after 50 hours of intensive computerized training delivered as a stand-alone treatment, but no improvement in symptoms or functioning. Serum @entity2252 levels were significantly increased, and may serve as a peripheral biomarker for the effects of training. Future research must focus on: 1) Methods of integrating cognitive training with psychosocial treatments; 2) A deeper understanding of underlying neurophysiology in order to enhance critical mechanisms of action.

title: Neuroscience-informed Auditory Training in XXXX : A Final Report of the Effects on Cognition and Serum @entity2252 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity2167 :: ('MESH:D006311', 'Disease') :: ['AT', 'auditory training']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive gains', 'gains in global cognition']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity2252 :: ('627', 'Gene') :: ['brain-derived neurotrophic factor', 'BDNF']

answer: @entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']


abstract: OBJECTIVE: We previously reported the interim effects in a per protocol analysis of a randomized controlled trial of an innovative neuroscience-informed computerized cognitive training approach in @entity161 . Here we report the effects of training on behavioral outcome measures in our final sample using an intent-to-treat analysis. We also report the effects on serum @entity2252 ( @entity2252 ). METHOD: Eighty-seven clinically stable @entity1 with @entity161 were randomly assigned to either targeted @entity2167 ( @entity2167 , N=46) or a computer games control condition (CG, N=41). @entity1 were assessed on neurocognition, symptoms and functional outcome at baseline and after 50 hours of intervention delivered over 10 weeks. Serum @entity2252 was assessed at baseline, at 2 weeks, and at 10 weeks. RESULTS: After the intervention, @entity2167 @entity1 showed significant @entity73 , speed of processing, verbal learning, and verbal memory, relative to CG @entity1 , with no changes in symptoms or functioning. At baseline, @entity161 @entity1 had significantly lower-than-normal serum @entity2252 . @entity2167 @entity1 showed a significant increase in serum @entity2252 compared to CG @entity1 , and "normalized" levels by post training. CONCLUSIONS: @entity1 with chronic @entity161 made significant @entity73 after 50 hours of intensive computerized training delivered as a stand-alone treatment, but no improvement in symptoms or functioning. Serum @entity2252 levels were significantly increased, and may serve as a peripheral biomarker for the effects of training. Future research must focus on: 1) Methods of integrating cognitive training with psychosocial treatments; 2) A deeper understanding of underlying neurophysiology in order to enhance critical mechanisms of action.

title: Neuroscience-informed Auditory Training in @entity161 : A Final Report of the Effects on Cognition and Serum XXXX .

answer: @entity2252 :: (627,Gene) :: ['Brain-Derived Neurotrophic Factor']


abstract: AIMS: Among @entity1 undergoing cryoballoon-based @entity955 ( @entity955 ) ablation, in order to reduce access site complications, improve staff ef   ciency, and decrease length of stay, various techniques have been implemented to achieve immediate haemostasis. We aimed to assess the efficacy and safety of 'figure-of-eight (FoE)' suture when compared with conventional manual compression for immediate closure of 15-French (Fr) calibre right femoral venous access after cryoablation. METHODS AND RESULTS: A total of 200 @entity1 (48% female, mean age 55    12.4 years, and 77% paroxysmal @entity955 ) with symptomatic @entity955 underwent initial cryoablation procedure. All the patients were anticoagulated with heparin during the procedure. In a sequential allocation, FoE suture (Group 1 = 100) and conventional manual compression (Group 2 = 100) were used in achieving haemostasis at right femoral venous access site following 15 @entity10267 . In the FoE suture group, haemostasis was achieved immediately after tying the knot (n = 95) or within  <=1 min of light pressure (n = 4). One @entity1 had failure of the stitch as the silk suture snapped during knotting, and haemostasis was achieved by manual compression as per the usual protocol. The median time to haemostasis was shorter in the suture group (0 vs. 14 min, P < 0.001). On immediate and short-term (3 months) follow-up, there was no evidence of minor or major vascular access site complications like haematoma, re-bleeding, @entity292 formation, or @entity715 at right femoral site in the suture group. CONCLUSION: The 'FoE' suture, as a simple, efficacious and likely safe technique, might be an alternative approach to achieve an immediate haemostasis after removal of 15 Fr right femoral @entity1211 in @entity1 undergoing cryoablation.

title: Usefulness of 'figure-of-eight' suture to achieve haemostasis after removal of 15-French calibre femoral XXXX in @entity1 undergoing cryoablation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous sheaths']

entities_list: @entity10267 :: ('MESH:C538037', 'Disease') :: ['Fr sheath removal']

answer: @entity1211 :: (MESH:D054556,Disease) :: ['venous sheath']


abstract: AIMS: Among @entity1 undergoing cryoballoon-based @entity955 ( @entity955 ) ablation, in order to reduce access site complications, improve staff ef   ciency, and decrease length of stay, various techniques have been implemented to achieve immediate haemostasis. We aimed to assess the efficacy and safety of 'figure-of-eight (FoE)' suture when compared with conventional manual compression for immediate closure of 15-French (Fr) calibre right femoral venous access after cryoablation. METHODS AND RESULTS: A total of 200 @entity1 (48% female, mean age 55    12.4 years, and 77% paroxysmal @entity955 ) with symptomatic @entity955 underwent initial cryoablation procedure. All the patients were anticoagulated with heparin during the procedure. In a sequential allocation, FoE suture (Group 1 = 100) and conventional manual compression (Group 2 = 100) were used in achieving haemostasis at right femoral venous access site following 15 @entity10267 . In the FoE suture group, haemostasis was achieved immediately after tying the knot (n = 95) or within  <=1 min of light pressure (n = 4). One @entity1 had failure of the stitch as the silk suture snapped during knotting, and haemostasis was achieved by manual compression as per the usual protocol. The median time to haemostasis was shorter in the suture group (0 vs. 14 min, P < 0.001). On immediate and short-term (3 months) follow-up, there was no evidence of minor or major vascular access site complications like haematoma, re-bleeding, @entity292 formation, or @entity715 at right femoral site in the suture group. CONCLUSION: The 'FoE' suture, as a simple, efficacious and likely safe technique, might be an alternative approach to achieve an immediate haemostasis after removal of 15 Fr right femoral @entity1211 in @entity1 undergoing cryoablation.

title: Usefulness of 'figure-of-eight' suture to achieve haemostasis after removal of 15-French calibre femoral @entity1211 in XXXX undergoing cryoablation.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Testicular and sexual function was investigated in 9 @entity1 between 16 and 28 years old with @entity15342 . At personal interview all @entity1 claimed to experience normal erections and orgasm but 7 had @entity2754 . Examination showed a normally developed male habitus. Orchiopexies had been performed in late childhood or adolescence. Two @entity1 were anorchic and the surviving testicles were small in the remaining 7. Serum @entity251 was low in 1 @entity1 and normal in 6 but at the expense of high luteinizing hormone levels in 4. All @entity1 had a high serum follicle-stimulating hormone level, reflecting the @entity3893 found in 5 @entity1 tested. Three biopsies from atypical cases showed poor histological findings but 2 revealed early spermatogenesis. The testes in @entity1 with @entity15342 are similar to undescended testes in otherwise normal @entity1 . Late orchiopexy produces sexually active but infertile @entity1 .

title: Testicular and sexual function in adults with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity15342 :: ('MESH:D011535', 'Disease') :: ['prune belly syndrome']

entities_list: @entity2754 :: ('MESH:D061686', 'Disease') :: ['retrograde ejaculation']

entities_list: @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']

answer: @entity15342 :: (MESH:D011535,Disease) :: ['prune belly syndrome']


abstract: @entity3799 is rare among adults. Thirty-two @entity1 with cervical @entity2696 were treated at the Mayo Clinic between 1950 and 1982. The records of these @entity1 were reviewed to investigate the clinical and pathologic behavior of this lesion in @entity1 more than 16 years of age. The lesions were seen in all decades of adult life and equally in @entity1 and @entity1 . Most lesions presented as a rapidly enlarging, asymptomatic mass. The anterior triangle of the neck was involved nearly as often as the posterior triangle, and right-sided locations predominated (72%). Histopathologic differentiation of the lesions into simplex, cavernous, and @entity3609 was not helpful in predicting clinical behavior. Surgical excision is the treatment of choice. The lesions may intimately involve the carotid sheath or adjacent nerves. Recurrence in 21% of the 28 @entity1 on whom follow-up data were available mostly represented incomplete excision. @entity2696 should be included in the differential diagnosis of a large asymptomatic neck mass of recent origin in the adult.

title: XXXX in the adult.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'persons', 'men']

entities_list: @entity3609 :: ('MESH:D018191', 'Disease') :: ['cystic lymphangiomas']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['Cervical lymphangioma']

entities_list: @entity2696 :: ('MESH:D008202', 'Disease') :: ['Lymphangioma', 'lymphangioma']

answer: @entity3799 :: (MESH:D002575,Disease) :: ['Cervical lymphangioma']


abstract: INTRODUCTION: There are two main methods to treat @entity3306 ( @entity3306 ) in @entity3541 . The first method is surgical intervention on the side of the @entity912 , and the second involves denervating the depressor muscles on the healthy side. It is sometimes difficult for @entity1 to ethically accept the denervating healthy tissue; therefore, we performed the T-shape double fascia graft (TSDFG), which reportedly restores symmetry. In this study, we report our experience with TSDFG and evaluation of the outcomes including the @entity1 questionnaires. METHODS: Two fascia strips from the thigh, 7  *  70  mm in size, were used; one was grafted horizontally at the lower lip to correct the static position, and the other was grafted obliquely at the lateral side by folding and crossing the horizontal fascia. A total of nine @entity1 were treated by this procedure; three procedures were performed individually and six were performed in combination with another static or reanimation procedure. A questionnaire containing a five-point scoring system for facial appearance in multiple situations and other problems was sent to each @entity1 at least 6 months after the surgery. RESULT: From the physicians' point of view, all @entity1 achieved an improvement in symmetry of the lower lip, particularly when opening of the mouth; however, assessments from the @entity1 demonstrated much less satisfaction. The main reason for the dissatisfaction was the slight bulkiness of the red lip. There was one comment that noted that with more treatment, the expectations were higher, and, as a result, the @entity1 could not admit satisfaction at the end. DISCUSSION: TSDFG is a simple and effective procedure for @entity3306 ; however, slight modifications may be required. In addition, there were some gaps in the perception of the results between the physicians and @entity1 , and we need to consider these when planning to treat @entity3306 .

title: Assessment of T-shape double fascia graft for lower XXXX from @entity3541 : A questionnaire survey.

entities_list: @entity3306 :: ('MESH:D008047', 'Disease') :: ['LLD', 'lower-lip deformity']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial paralysis']

entities_list: @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']

answer: @entity3306 :: (MESH:D008047,Disease) :: ['lip deformity']


abstract: INTRODUCTION: There are two main methods to treat @entity3306 ( @entity3306 ) in @entity3541 . The first method is surgical intervention on the side of the @entity912 , and the second involves denervating the depressor muscles on the healthy side. It is sometimes difficult for @entity1 to ethically accept the denervating healthy tissue; therefore, we performed the T-shape double fascia graft (TSDFG), which reportedly restores symmetry. In this study, we report our experience with TSDFG and evaluation of the outcomes including the @entity1 questionnaires. METHODS: Two fascia strips from the thigh, 7  *  70  mm in size, were used; one was grafted horizontally at the lower lip to correct the static position, and the other was grafted obliquely at the lateral side by folding and crossing the horizontal fascia. A total of nine @entity1 were treated by this procedure; three procedures were performed individually and six were performed in combination with another static or reanimation procedure. A questionnaire containing a five-point scoring system for facial appearance in multiple situations and other problems was sent to each @entity1 at least 6 months after the surgery. RESULT: From the physicians' point of view, all @entity1 achieved an improvement in symmetry of the lower lip, particularly when opening of the mouth; however, assessments from the @entity1 demonstrated much less satisfaction. The main reason for the dissatisfaction was the slight bulkiness of the red lip. There was one comment that noted that with more treatment, the expectations were higher, and, as a result, the @entity1 could not admit satisfaction at the end. DISCUSSION: TSDFG is a simple and effective procedure for @entity3306 ; however, slight modifications may be required. In addition, there were some gaps in the perception of the results between the physicians and @entity1 , and we need to consider these when planning to treat @entity3306 .

title: Assessment of T-shape double fascia graft for lower @entity3306 from XXXX : A questionnaire survey.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity3541 :: (MESH:D005158,Disease) :: ['facial paralysis']


abstract: The principal treatment concept in the Utrecht @entity995 Centre is megavoltage irradiation, followed by @entity3459 and/or cryotherapy if there is any doubt as to whether the @entity5 is still active. Radiation therapy is administered by means of a simple but highly accurate temporal beam technique. A standardized dose of 45 Gy is given in 15 fractions of 3 Gy at 3 fractions per week. From 1971 to 1982, 39 @entity1 with @entity995 have been irradiated in at least one eye. Of the 73 affected eyes, 18 were primarily enucleated, one received @entity3459 only, and 54 received radiation therapy. Of the 54 @entity735 , 32 were additionally treated by @entity3459 and/or cryotherapy for suspicious @entity5 (in 29 eyes), recurrent @entity5 (in 3 eyes) and 10 were ultimately enucleated. Two eyes also received @entity221 . The percentages of cure of the @entity735 with a minimum follow-up of 2 years were 100% (14/14), 100% (9/9), 83% (10/12), 79% (11/14) and 0% (0/5) in the Reese-Ellsworth groups I to V-A, respectively. Of the saved eyes 95% achieved useful vision. Eighteen eyes developed a clinically detectable radiation @entity231 ; in five of these the lens was aspirated. Cataracts developed exclusively in those lenses of which a posterior portion of more than 1 mm had to be included in the treatment field. The likelihood and the degree of @entity231 formation was found to be directly related to the dose of radiation to the germinative zone of the lens epithelium. The minimum cataractogenic dose found in this series was 8 Gy.

title: Treatment of XXXX by precision megavoltage radiation therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['residual tumour', 'tumour (in 1 eye), and/or new tumour']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['light coagulation']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['irradiated eyes']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['Retinoblastoma', 'retinoblastoma']

answer: @entity995 :: (MESH:D012175,Disease) :: ['retinoblastoma']


abstract: To evaluate the capability of magnetic resonance (MR) in imaging normal acoustic nerves, 12 volunteers without signs or symptoms of @entity1504 were examined using a 0.6 T superconductive system. Several @entity9468 ( @entity9468 ) pulse sequences were tested to identify the optimal sequence for demonstration of the acoustic nerve bundle. Repetition times (TRs) varied from 300 to 2000 msec and echo times (TEs) from 30 to 120 msec. A single-slice technique was used with 5 and 8 mm sections, one or two data acquisitions per projection, and axial and coronal imaging. The normal acoustic nerves were demonstrated readily by MR in axial and/or coronal sections. The distal parts of the nerves and @entity5 were imaged best with @entity9468 1500/60. The @entity2103 tended to be obscured in this sequence by brightening the cerebrospinal fluid signal adjacent to the brainstem, but they were demonstrated clearly with 500 or 800 msec TR and 30 msec TE. Five @entity1 were studied who had @entity393 and evidence of @entity28540 . In four @entity1 , MR imaging demonstrated five acoustic nerve @entity5 ranging in size from purely intracanalicular to a 12 mm cisternal component. In the fifth case, no @entity5 was identified by MR imaging or gas computed tomographic (CT) cisternography. Contrast-enhanced CT using a Siemens Somatom DR 3 or GE CT/T 8800 scanner failed to provide convincing evidence of @entity5 in any case, while gas CT cisternography was positive in all five @entity5 . All five @entity5513 were identified readily using the @entity9468 sequences that proved optimal for demonstration of normal nerves. This experience revealed that MR imaging can demonstrate the eighth nerve complex well and reliably. @entity302 (5 or 8 mm) technique is adequate, but multislice without tissue gaps (used recently) is more efficient. Small, even intracanalicular, @entity5513 are imaged effectively, indicating that the method is capable of superseding contrast CT cisternography, particularly with improving technology.

title: MR imaging of the acoustic nerves and small XXXX at 0.6 T: prospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5513 :: ('MESH:D009464', 'Disease') :: ['acoustic neuromas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity2103 :: ('MESH:D005155', 'Disease') :: ['medial extremities of the seventh and eighth nerves']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial disease']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['Single-slice']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity28540 :: ('MESH:D012181', 'Disease') :: ['retrocochlear disease']

answer: @entity5513 :: (MESH:D009464,Disease) :: ['acoustic neuromas']


abstract: A series of 215 @entity1 with @entity263 localized to the pelvis received radical radiotherapy. Treatment results have been correlated with the @entity5 stage, @entity5 size defined independently from stage, doses of radiation and histological grade. The following ranges from 2 to 13 years (median 5 years). Local recurrence was observed in 6.6 percent of stage B, 16.1 per cent of stage C and 20 per cent of stage D1 cases. Eighty per cent of the @entity1 with stage B disease, 56 per cent with stage C and 0 per cent with stage D1 survived 5 years free of disease. Tumors less than 2 cm. in diameter were controlled uniformly, while @entity5 more than 2 cm. in diameter showed an over-all local control rate of about 85 per cent. Increasing size resulted in a higher incidence of distant metastases. A dose of 6,500 rad (180 to 200 rad per day) appears adequate for @entity5 less than 2 cm. in diameter and stage B @entity5 , while higher stage @entity5 require doses of 7,000 rad (180 to 200 rad per day). Most high grade @entity5 and massive @entity5 of any grade fail outside the pelvis.

title: Prognostic parameters in radiotherapeutic management of localized XXXX .

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['carcinoma of the prostate']

answer: @entity263 :: (MESH:D011471,Disease) :: ['carcinoma of the prostate']


abstract: We determined the details of ventricular activation sequence during the onset of @entity2224 in 6 @entity235 . Unipolar electrograms were simultaneously recorded from 192 ventricular epicardial sites evenly spaced in a 3 by 3 cm square area surrounding 2 central sites to which stimuli for inducing @entity955 were delivered. In 5 @entity235 , 2 to 10 msec duration pulses with amplitudes of 150 to 220 v were used to induce @entity955 , and in 1 @entity235 , 3 successive permature stimuli of 3 v intensity were used to induce @entity955 . In 2 @entity235 the pattern of activation at the onset of @entity955 was compatible with local reentrant paths near the stimulus site. Fibrillation was induced with a single high intensity pulse in both of these @entity235 . In the other 4 @entity235 , the pattern of activation at the onset of @entity955 was highly suggestive of reentrant paths distant from the stimulating electrodes. In 3 of these @entity235 @entity955 was induced by a single high intensity pulse and in the other it was induced by 3 repetitive stimuli. Activation patterns resembling supraventricular activation occurred prior to @entity955 in the latter animal. The data demonstrate 2 distinct modes of onset of electrically induced @entity2224 . The findings support local reentry in the region of the stimulus site as the mode of onset of @entity955 in some animals and possible reentry at sites distant from the stimulus site with participation of the specialized conduction system in other animals. The differences in mode of onset of electrically induced @entity955 may be responsible for instability of @entity955 threshold measurements in some animals. In addition the role of the specialized conduction system in the onset of @entity955 may be responsible for the effects of sympathetic and vagal stimulation on @entity955 threshold.

title: Detailed activation sequence in the region of electrically induced XXXX in @entity235 .

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['fibrillation']

answer: @entity2224 :: (MESH:D014693,Disease) :: ['ventricular fibrillation']


abstract: We determined the details of ventricular activation sequence during the onset of @entity2224 in 6 @entity235 . Unipolar electrograms were simultaneously recorded from 192 ventricular epicardial sites evenly spaced in a 3 by 3 cm square area surrounding 2 central sites to which stimuli for inducing @entity955 were delivered. In 5 @entity235 , 2 to 10 msec duration pulses with amplitudes of 150 to 220 v were used to induce @entity955 , and in 1 @entity235 , 3 successive permature stimuli of 3 v intensity were used to induce @entity955 . In 2 @entity235 the pattern of activation at the onset of @entity955 was compatible with local reentrant paths near the stimulus site. Fibrillation was induced with a single high intensity pulse in both of these @entity235 . In the other 4 @entity235 , the pattern of activation at the onset of @entity955 was highly suggestive of reentrant paths distant from the stimulating electrodes. In 3 of these @entity235 @entity955 was induced by a single high intensity pulse and in the other it was induced by 3 repetitive stimuli. Activation patterns resembling supraventricular activation occurred prior to @entity955 in the latter animal. The data demonstrate 2 distinct modes of onset of electrically induced @entity2224 . The findings support local reentry in the region of the stimulus site as the mode of onset of @entity955 in some animals and possible reentry at sites distant from the stimulus site with participation of the specialized conduction system in other animals. The differences in mode of onset of electrically induced @entity955 may be responsible for instability of @entity955 threshold measurements in some animals. In addition the role of the specialized conduction system in the onset of @entity955 may be responsible for the effects of sympathetic and vagal stimulation on @entity955 threshold.

title: Detailed activation sequence in the region of electrically induced @entity2224 in XXXX .

answer: @entity235 :: (9615,Species) :: ['dogs']


abstract: The authors report a series of 13 @entity1 , 8 @entity1 and 5 @entity1 , with an average age of 68 years (range 39 to 87 years) presenting with documented @entity1188 with anteroseptal extension in 2 cases. These @entity1 developed LBBB (complete in 9 cases, incomplete in 4 cases). This complications occurred in the acute phase in 8 cases and 4 months to 9 years later (average 4,5 years) in the other 5 cases. The block was intermittent in 4 @entity1 and became permanent in all cases. The diagnosis of @entity1188 with LBBB was made by vectorcardiography (VCG) in 5 out of the 13 @entity1 (38,4 p. 100) on the criteria suggested by Starr. 3 of the 8 false negative results were directly related to the block which masked the ECG and VCG signs of @entity1188 . The VCG signs observed were an upwards displacement of the QRS loop with preservation of the superior orientation of the initial forces (5 cases). Atypical appearances of LBBB were observed in 2 cases with a posterior and right-sided shift of the efferent loop following the anterior and left-sided orientations of the initial forces. The sensitivity of the VCG and ECG is mediocre in @entity1188 with LBBB because the block may mask the electrical signs of @entity1188 . The specificity of the VCG could not be assessed because of the mode of selection of the @entity1 and the small number of cases.

title: [Vectorcardiography in XXXX associated with left bundle-branch block].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women', 'men']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['inferior infarction']

answer: @entity1188 :: (MESH:D007238,Disease) :: ['inferior infarction']


abstract: A saccharolytic spirochete that associated and interacted with cellulolytic bacteria was isolated from @entity291 rumen fluid. Isolation was accomplished by means of a procedure involving serial dilution of a sample of rumen fluid into a cellulose-containing agar medium. Clear zones appeared within the medium as a result of cellulose hydrolysis by rumen bacteria. The saccharolytic spirochete and a cellulolytic bacterium later identified as a strain of Bacteroides succinogenes were isolated from the clear zones. The spirochete did not utilize cellulose, but grew in coculture with the cellulotytic bacterium in cellulose-containing media. When cocultured in these media the spirochete used, as fermentable substrates, soluble @entity3363 released from cellulose by the cellulolytic bacterium. In cellulose-containing agar medium the spirochete enhanced cellulose breakdown by the @entity15898 . Electron microscopy showed that the helical spirochete cells possessed an outer sheath, a protoplasmic cylinder, and two periplasmic fibrils. Under a @entity515 atmosphere, in a reduced medium containing inorganic salts, rumen fluid, @entity413 , and @entity5993 , the spirochete grew to a final density of 1.9 X 10(9) cells/ml. @entity4588 , @entity598 , and @entity5189 were products of the fermentation of @entity413 by growing cells. @entity515 ( @entity3157 ), branched @entity22780 , @entity1501 , @entity1885 , @entity4571 , @entity9138 , @entity2765 , and a @entity1735 were required for growth of the spirochete. The results of this study indicated that the rumen spirochete represents a new species of @entity16642 . It is proposed that the new species be named @entity16642 bryantii.

title: XXXX bryantii sp. nov., a rumen spirochete that interacts with cellulolytic bacteria.

entities_list: @entity1501 :: ('MESH:D005492', 'Chemical') :: ['folic acid']

entities_list: @entity2765 :: ('MESH:D011730', 'Chemical') :: ['pyridoxal']

entities_list: @entity4588 :: ('MESH:D019802', 'Chemical') :: ['Succinate']

entities_list: @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate']

entities_list: @entity9138 :: ('MESH:D013831', 'Chemical') :: ['thiamine']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity22780 :: ('MESH:D005232', 'Chemical') :: ['short-chain fatty acids']

entities_list: @entity4571 :: ('MESH:D009536', 'Chemical') :: ['niacinamide']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity15898 :: ('833', 'Species') :: ['B. succinogenes strain']

answer: @entity16642 :: (MESH:C531782,Disease) :: ['Treponema']


abstract: In several countries the suicide rate for @entity146 inpatients has increased more than that for admissions and suicides in the general population. This was also the case in our clinic. This hypothesis was tested: today, because of more liberal management, suicides are committed during hospitalization that in an earlier and more restrictive age would have taken place after discharge. All suicides taking place 1960-1979 in the clinic's main catchment area were examined for previous hospitalization. The hypothesis was not supported. Over twenty years neither the suicide cases nor all discharged @entity1 changed significantly in distribution of age, sex, number of previous admissions, duration of hospitalization, or diagnosis. Therefore, none of these variables explain the increase. In both decades, on the other hand, @entity1 that committed suicide during their stay at the clinic had been hospitalized longer; those that committed suicide within three months after discharge had been hospitalized for a shorter time than the sum of discharged @entity1 . Among the suicides that occurred after discharge, the percentage of @entity308 and addicts was higher and the percentage of @entity161 @entity1 was smaller than among all discharged @entity1 . A change in @entity1 management (more time off, more working outside, more open wards) has preceded the increase in suicides; medical staff, however, has doubled over the decades considered here. Rising pressure for resocialization to avoid hospitalism may heighten suicidal behavior. Preventive measures are discussed.

title: [Increasing suicides of XXXX inpatients: reality or artefact? (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressives']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenic']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: To compare abdomonal aortic surgery for aneurysmal ( @entity11557 ) vs occlusive (OCC) disease, 50 consecutive cases of elective bifurcation grafts for @entity11557 and 50 consecutive cases for OCC disease were analyzed. The mean age of the @entity11557 @entity1 was a decade greater than the OCC @entity1 , and they had more associated diseases. Only six @entity11557 @entity1 were @entity1 , while @entity1 predominated in the OCC group. Only three @entity11557 @entity1 were claudicants and none had @entity158 . About one third of the OCC group had distal disease, and 14 had @entity158 . Operative mortality was 4% (two deaths in each group). The survival of the grafted @entity11557 @entity1 was almost equal to normal expectancy. There were no late thromboses of grafts in the @entity11557 group, while there were five late failures in the OCC group. The OCC group underwent significantly more frequent reoperative surgery during the follow-up period. The numerous differences in the two population groups apparent in this study provide a basis for questioning the concept that @entity439 are caused by @entity731 .

title: Differences in results for XXXX vs occlusive disease after bifurcation grafts: results of 100 elective grafts.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['rest pain']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

answer: @entity439 :: (MESH:D000783,Disease) :: ['aneurysm']


abstract: Very few studies have been described comparing the value of exercise @entity296 and left @entity67 . The authors designed a study comparing these two investigations with conventional exercise stress testing and coronary angiography. The isotopic investigations were carried out within 48 hours of coronary angiography. A total of 143 @entity1 undergoing coronary angiography (35 normal, 108 coronary @entity1 : 36 single vessel, 36 double vessel and 36 @entity66 ) were included in this study. The lesions were located of the @entity3980 (77 cases), left circumflex (77 cases) and right coronary arteries (62). The sensitivity and specificity of both radionuclide investigations were evaluated to assess their diagnostic value; the best results were obtained with @entity296 (sensitivity 86 p. 100; specificity 100 p. 100); angioscintigraphy had a sensitivity of 71 p. 100 and specificity of 97 p. 100, and conventional exercise stress testing of 42 p. 100 and 70 p. 100 respectively. The sensitivity seemed to increase with the degree of @entity850 ; although the sensitivity of @entity296 increased progressively, that of angioscintigraphy doubled in cases of @entity850 90 p. 100 ( @entity850 less than 90 p. 100, sensitivity = 37 p. 100; @entity850 greater than 90 p. 100, sensitivity = 73 p. 100). The sensitivity of @entity296 with respect to the severity of the @entity453 was best in cases of @entity3979 (sensitivity in cases of RCA @entity850 = 74 p. 100; sensitivity in @entity3980 @entity850 = 58 p. 100; sensitivity in left circumflex @entity850 = 43 p. 100). The sensitivity of left @entity67 was @entity3980 (RCA @entity850 = 50 p. 100, @entity3980 @entity850 = 64 p. 100, left circumflex @entity850 = 36 p. 100). The sensitivity of both investigations was poor in left circumflex @entity2791 even when severely diseased. The sensitivity of both investigations was better in diffuse @entity453 : @entity296 ( @entity66 : 72 p. 100, @entity66 : 92 p. 100, @entity66 : 94 p. 100), left @entity67 (61 p. 100, 69 p. 100, and 83 p. 100 respectively). Although the association of these two radioisotopic investigations does not improve diagnostic sensitivity, it does provide more information about the localisation and extension of the @entity453 especially in @entity3980 and @entity3979 . These results suggest that these investigations are complementary in the evaluation of @entity1 with @entity453 .(ABSTRACT TRUNCATED AT 400 WORDS)

title: [Exertion isotope tests in coronary insufficiency. Comparison with isotopic ventriculography and XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial scintigraphy']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['triple vessel disease', 'double vessel disease', 'single vessel disease']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['artery stenosis']

entities_list: @entity3979 :: ('MESH:D023921', 'Disease') :: ['right coronary artery stenosis']

entities_list: @entity3980 :: ('MESH:C535887', 'Disease') :: ['LAD', 'best in LAD stenosis']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular angioscintigraphy']

answer: @entity296 :: (MESH:D009202,Disease) :: ['myocardial scintigraphy']


abstract: A twice-a-day treatment schedule has been used to manage 57 @entity1 with moderately advanced and advanced @entity957 of the head and neck between March 1978 and July 1981. Fifty @entity1 received radiation therapy alone to the primary site with neck dissection added in 13; seven received preoperative irradiation followed by resection of the @entity75 and clinically positive lymph nodes. A dose of 120 rad was delivered twice daily to the primary site and upper neck nodes with a 4- to 6-hour interval. The dose from external beam was usually 7440 to 7680 rad for irradiation alone to the primary site. An interstitial implant boost of 1000 to 1500 rad was added in four @entity1 . When at least 7440 was used, 2 of 3 and 11 of 13 T3 lesions were locally controlled with a 2- to 5-year follow-up. T4 lesions were initially treated with 7440 rad, but only one of ten lesions was controlled; the dose was then increased to 7680 to 8100 rad, with or without an implant, and three of eight T4 lesions were controlled. The acute effects were tolerable, and similar to those seen with once-a-day treatments. There has been one possible severe complication of irradiation and two severe complications of salvage operations. The late normal tissue effects of radiation are probably reduced, but the number of @entity1 observed for 4 and 5 years is limited. Determinate survival free of disease at 2 years for the entire group is 47%. The 2-year determinate disease-free survival for Stage III was 86% (6/7), for Stage IVA, 63% (12/19), and for Stage IVB, 22% (5/23).

title: Twice-a-day irradiation technique for XXXX of the head and neck.

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['primary lesion']

answer: @entity957 :: (MESH:D002294,Disease) :: ['squamous cell carcinomas']


abstract: The treatment philosophy of anal canal @entity189 is changing. Abdominoperineal resection (APR) with a permanent colostomy is beginning to be replaced by lesser surgical techniques, such as excisional biopsy in a multimodality approach. Radical radiation therapy is capable of eradicating the @entity5 and yielding a high survival rate. External radiation therapy alone has been reported to result in 80% local control and 79% 5-year actuarial survival. Combining external radiation therapy with brachytherapy has yielded a 65% 5-year disease-free survival. Combined chemotherapy and radiation therapy, i.e., preoperative @entity1487 and @entity1138 , with 3000 rad pelvic irradiation, allowed over 50% of the @entity1 in each of two previous studies to be spared an APR. Close examination of the data shows that APR may not have been necessary in those who had it. Frequently, no disease was found in the resected specimen. When disease was present, there was a high rate of local recurrence in spite of APR. Although the ideal treatment may not be devised, @entity1 are beginning to be cured of this disease while still retaining a functional anal sphincter.

title: Treatment of anal canal XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor']

entities_list: @entity1138 :: ('MESH:D016685', 'Chemical') :: ['mitomycin C']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity189 :: (MESH:D002277,Disease) :: ['carcinoma']


abstract: The levels of @entity4663 ( @entity7224 , @entity11667 and @entity8037 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity320 grown in the lungs of DBA/2 @entity19 . @entity4664 levels and the numbers of @entity5 -cell colonies in the lungs were determined at weekly intervals. @entity7224 levels in both erythrocytes and plasma significantly increased 1 week after @entity5 inoculation. Three weeks after inoculation, however, @entity7224 levels in the erythrocytes showed a greater increase than those in plasma. @entity11667 and @entity8037 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity11667 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4663 released into the circulation.This finding was subsequently applied to @entity1 studies. Fifty-two untreated @entity1 with solid @entity5 were examined in the preoperative period. All erythrocyte @entity4664 levels from @entity1 were significantly higher than those from control subjects. Plasma @entity11667 levels in @entity1 were significantly higher than those in controls, whereas plasma @entity7224 and @entity8037 levels showed no significant increase. The frequency of raised levels of @entity7224 , @entity11667 and @entity8037 in erythrocytes was significantly greater than in plasma. These results suggest that @entity4664 levels in erythrocytes may provide useful information for the detection of @entity5 .

title: Raised @entity4663 in erythrocytes from XXXX -bearing @entity19 and @entity1 with solid @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours', 'tumour']

entities_list: @entity8037 :: ('MESH:D013096', 'Chemical') :: ['spermine']

entities_list: @entity7224 :: ('MESH:D011700', 'Chemical') :: ['putrescine', 'Putrescine']

entities_list: @entity4663 :: ('MESH:D011073', 'Chemical') :: ['polyamines']

entities_list: @entity4664 :: ('CHEBI:60143', 'Chemical') :: ['Polyamine', 'polyamine']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

entities_list: @entity11667 :: ('MESH:D013095', 'Chemical') :: ['Spermidine', 'spermidine']

answer: @entity320 :: (MESH:D008545,Disease) :: ['melanoma']


abstract: The levels of @entity4663 ( @entity7224 , @entity11667 and @entity8037 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity320 grown in the lungs of DBA/2 @entity19 . @entity4664 levels and the numbers of @entity5 -cell colonies in the lungs were determined at weekly intervals. @entity7224 levels in both erythrocytes and plasma significantly increased 1 week after @entity5 inoculation. Three weeks after inoculation, however, @entity7224 levels in the erythrocytes showed a greater increase than those in plasma. @entity11667 and @entity8037 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity11667 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4663 released into the circulation.This finding was subsequently applied to @entity1 studies. Fifty-two untreated @entity1 with solid @entity5 were examined in the preoperative period. All erythrocyte @entity4664 levels from @entity1 were significantly higher than those from control subjects. Plasma @entity11667 levels in @entity1 were significantly higher than those in controls, whereas plasma @entity7224 and @entity8037 levels showed no significant increase. The frequency of raised levels of @entity7224 , @entity11667 and @entity8037 in erythrocytes was significantly greater than in plasma. These results suggest that @entity4664 levels in erythrocytes may provide useful information for the detection of @entity5 .

title: Raised XXXX in erythrocytes from @entity320 -bearing @entity19 and @entity1 with solid @entity5 .

answer: @entity4663 :: (MESH:D011073,Chemical) :: ['polyamines']


abstract: The levels of @entity4663 ( @entity7224 , @entity11667 and @entity8037 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity320 grown in the lungs of DBA/2 @entity19 . @entity4664 levels and the numbers of @entity5 -cell colonies in the lungs were determined at weekly intervals. @entity7224 levels in both erythrocytes and plasma significantly increased 1 week after @entity5 inoculation. Three weeks after inoculation, however, @entity7224 levels in the erythrocytes showed a greater increase than those in plasma. @entity11667 and @entity8037 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity11667 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4663 released into the circulation.This finding was subsequently applied to @entity1 studies. Fifty-two untreated @entity1 with solid @entity5 were examined in the preoperative period. All erythrocyte @entity4664 levels from @entity1 were significantly higher than those from control subjects. Plasma @entity11667 levels in @entity1 were significantly higher than those in controls, whereas plasma @entity7224 and @entity8037 levels showed no significant increase. The frequency of raised levels of @entity7224 , @entity11667 and @entity8037 in erythrocytes was significantly greater than in plasma. These results suggest that @entity4664 levels in erythrocytes may provide useful information for the detection of @entity5 .

title: Raised @entity4663 in erythrocytes from @entity320 -bearing @entity19 and @entity1 with solid XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumours']


abstract: The levels of @entity4663 ( @entity7224 , @entity11667 and @entity8037 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity320 grown in the lungs of DBA/2 @entity19 . @entity4664 levels and the numbers of @entity5 -cell colonies in the lungs were determined at weekly intervals. @entity7224 levels in both erythrocytes and plasma significantly increased 1 week after @entity5 inoculation. Three weeks after inoculation, however, @entity7224 levels in the erythrocytes showed a greater increase than those in plasma. @entity11667 and @entity8037 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity11667 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4663 released into the circulation.This finding was subsequently applied to @entity1 studies. Fifty-two untreated @entity1 with solid @entity5 were examined in the preoperative period. All erythrocyte @entity4664 levels from @entity1 were significantly higher than those from control subjects. Plasma @entity11667 levels in @entity1 were significantly higher than those in controls, whereas plasma @entity7224 and @entity8037 levels showed no significant increase. The frequency of raised levels of @entity7224 , @entity11667 and @entity8037 in erythrocytes was significantly greater than in plasma. These results suggest that @entity4664 levels in erythrocytes may provide useful information for the detection of @entity5 .

title: Raised @entity4663 in erythrocytes from @entity320 -bearing XXXX and @entity1 with solid @entity5 .

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: The levels of @entity4663 ( @entity7224 , @entity11667 and @entity8037 ) in erythrocytes and plasma were studied using Cloudman S-91 @entity320 grown in the lungs of DBA/2 @entity19 . @entity4664 levels and the numbers of @entity5 -cell colonies in the lungs were determined at weekly intervals. @entity7224 levels in both erythrocytes and plasma significantly increased 1 week after @entity5 inoculation. Three weeks after inoculation, however, @entity7224 levels in the erythrocytes showed a greater increase than those in plasma. @entity11667 and @entity8037 levels were initially high at 2 weeks in plasma and at 4 weeks in erythrocytes. However, by 6 weeks the @entity11667 levels showed a greater increase in erythrocytes than in plasma. These data suggest that erythrocytes may absorb and store @entity4663 released into the circulation.This finding was subsequently applied to @entity1 studies. Fifty-two untreated @entity1 with solid @entity5 were examined in the preoperative period. All erythrocyte @entity4664 levels from @entity1 were significantly higher than those from control subjects. Plasma @entity11667 levels in @entity1 were significantly higher than those in controls, whereas plasma @entity7224 and @entity8037 levels showed no significant increase. The frequency of raised levels of @entity7224 , @entity11667 and @entity8037 in erythrocytes was significantly greater than in plasma. These results suggest that @entity4664 levels in erythrocytes may provide useful information for the detection of @entity5 .

title: Raised @entity4663 in erythrocytes from @entity320 -bearing @entity19 and XXXX with solid @entity5 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The aim of the present study was to investigate, with extracellular recording and microiontophoretic techniques, the possibility that @entity1246 ( @entity1246 ) is the transmitter substance in the pallido-subthalamic (GP-STN) pathway. Experiments were carried out in 94 @entity35 , anesthetized with @entity3652 . Among the 236 recorded STN neurons, 85 were inhibited by GP stimulation. This inhibition lasted 10--20 msec (mean duration +/- S.E.M. 13.45 +/- 0.5 msec). Control stimulations located either in the internal GP or in the striatum never elicited the same type of response as they did in the STN. STN neurons were inhibited by microiontophoretically applied @entity1246 or @entity6341 . Iontophoretically applied @entity1027 or @entity5094 reversibly blocked the GP-evoked inhibition at doses which blocked the @entity1246 inhibitory responses but not those produced by @entity2228 . The results are consistent with the hypothesis that @entity1246 is the transmitter releasted by the inhibitory pallido-subthalamic pathway, and are in agreement with recent biochemical data. Nevertheless, on a few cells, @entity1026 blocked the GP-induced inhibition. This results is discussed in relation to the specificty of @entity1246 and @entity2228 antagonists.

title: Pharmacological blockade of the globus palidus-induced inhibitory response of subthalamic cells in the XXXX .

entities_list: @entity1026 :: ('MESH:D013331', 'Chemical') :: ['strychnine']

entities_list: @entity6341 :: ('MESH:D009118', 'Chemical') :: ['muscimol']

entities_list: @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid', 'GABA']

entities_list: @entity2228 :: ('CHEBI:57305', 'Chemical') :: ['glycine']

entities_list: @entity1027 :: ('MESH:D001640', 'Chemical') :: ['bicuculline']

entities_list: @entity3652 :: ('MESH:D007649', 'Chemical') :: ['ketamine']

entities_list: @entity5094 :: ('MESH:D010852', 'Chemical') :: ['picrotoxin']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: The effects of HMG (Humegon)-HCG therapy in 6096 cycles in 2166 Japanese @entity1 with @entity249 were examined. The rates of ovulation, pregnancy, the @entity43 , @entity5852 , and @entity600 in the newborn were recorded, and the possible factors of multiple pregnancies were analyzed. Ovulation occurred in 73.2% of the cases and 64.5% of the treatment cycles. Pregnancy occurred in 23.0% of the cases and 8.6% of the cycles. @entity43 with grade I of WHO definition or more was observed in 10.3% of the cases and 5.3% of the cycles. The incidence of the @entity43 was high in amenorrheic @entity1 , who respond to @entity1871 with @entity548 . The multiple pregnancy rate was 20.5%, of which 13.0% was twins and 7.5% triplets or more. The abortion rate was 22.0%, and the abortion rate in multiple pregnancy was significantly higher (P less than 0.05) than that in singleton pregnancy. The external @entity600 rate was 1.68% in the 594 newborn who could be examined. No significant differences were found in maternal factors, the treatment schedule, or the ovarian response to treatment in singleton and multiple pregnancy groups. This survey revealed that the efficacy and the incidence of adverse effects of Humegon-HCG therapy in a large number of Japanese @entity1 were not different from those in Caucasians except for a lower rate of multiple pregnancy, and no special causative factors for multiple pregnancy were found.

title: Results of HMG (Humegon)-HCG therapy in 6096 treatment cycles of 2166 Japanese @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian hyperstimulation syndrome', 'Ovarian hyperstimulation syndrome']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['anovulatory infertility']

entities_list: @entity5852 :: ('MESH:D000031', 'Disease') :: ['multiple pregnancy, abortion']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations', 'malformation']

entities_list: @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin']

answer: @entity249 :: (MESH:D007246,Disease) :: ['anovulatory infertility']


abstract: The effects of HMG (Humegon)-HCG therapy in 6096 cycles in 2166 Japanese @entity1 with @entity249 were examined. The rates of ovulation, pregnancy, the @entity43 , @entity5852 , and @entity600 in the newborn were recorded, and the possible factors of multiple pregnancies were analyzed. Ovulation occurred in 73.2% of the cases and 64.5% of the treatment cycles. Pregnancy occurred in 23.0% of the cases and 8.6% of the cycles. @entity43 with grade I of WHO definition or more was observed in 10.3% of the cases and 5.3% of the cycles. The incidence of the @entity43 was high in amenorrheic @entity1 , who respond to @entity1871 with @entity548 . The multiple pregnancy rate was 20.5%, of which 13.0% was twins and 7.5% triplets or more. The abortion rate was 22.0%, and the abortion rate in multiple pregnancy was significantly higher (P less than 0.05) than that in singleton pregnancy. The external @entity600 rate was 1.68% in the 594 newborn who could be examined. No significant differences were found in maternal factors, the treatment schedule, or the ovarian response to treatment in singleton and multiple pregnancy groups. This survey revealed that the efficacy and the incidence of adverse effects of Humegon-HCG therapy in a large number of Japanese @entity1 were not different from those in Caucasians except for a lower rate of multiple pregnancy, and no special causative factors for multiple pregnancy were found.

title: Results of HMG (Humegon)-HCG therapy in 6096 treatment cycles of 2166 Japanese XXXX with @entity249 .

answer: @entity1 :: (9606,Species) :: ['women']


abstract: High-dose @entity1499 in a dose of 2-4 g/m2 every four weeks was given as secondary chemotherapy to 22 @entity1 with metastatic soft-tissue @entity242 ; toxic reactions included 1 @entity204 and 2 instances of moderate @entity137 . The remaining @entity1 tolerated this treatment without difficulty. Of 18 @entity1 with measurable evaluable disease, 17 demonstrated progression. One @entity1 with @entity5426 had a complete response lasting for 15 months. Three @entity1 were given adjuvant high-dose @entity1499 following wedge resections of pulmonary @entity3 . One @entity1 demonstrated recurrence after four months, another after 13 months, and the third after 15 months. One additional @entity1 underwent resection of pulmonary @entity3 following two months of stabilization with high-dose @entity1499 and has continued free of disease with high-dose @entity1499 as adjuvant for eight months. Five @entity1 are alive and have been disease-free for an average period of 14 months. Four of these underwent operative treatment combined with chemotherapy. The effectiveness of high-dose @entity1499 appears limited in soft-tissue @entity242 when it is given as secondary chemotherapy.

title: High-dose XXXX as secondary chemotherapy in metastatic soft-tissue @entity242 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['hematopoietic toxicity']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['metastatic angiosarcoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: High-dose @entity1499 in a dose of 2-4 g/m2 every four weeks was given as secondary chemotherapy to 22 @entity1 with metastatic soft-tissue @entity242 ; toxic reactions included 1 @entity204 and 2 instances of moderate @entity137 . The remaining @entity1 tolerated this treatment without difficulty. Of 18 @entity1 with measurable evaluable disease, 17 demonstrated progression. One @entity1 with @entity5426 had a complete response lasting for 15 months. Three @entity1 were given adjuvant high-dose @entity1499 following wedge resections of pulmonary @entity3 . One @entity1 demonstrated recurrence after four months, another after 13 months, and the third after 15 months. One additional @entity1 underwent resection of pulmonary @entity3 following two months of stabilization with high-dose @entity1499 and has continued free of disease with high-dose @entity1499 as adjuvant for eight months. Five @entity1 are alive and have been disease-free for an average period of 14 months. Four of these underwent operative treatment combined with chemotherapy. The effectiveness of high-dose @entity1499 appears limited in soft-tissue @entity242 when it is given as secondary chemotherapy.

title: High-dose @entity1499 as secondary chemotherapy in metastatic soft-tissue XXXX .

answer: @entity242 :: (MESH:D012509,Disease) :: ['sarcomas']


abstract: A long pause after an abnormal heat during @entity955 has been called a "compensatory pause" and has been used to identify @entity1540 ( @entity1540 ) and to differentiate them from supraventricular beats with aberration. The diagnostic value of the compensatory pause is controversial and has not been tested systematically with programmed stimulation and intracardiac recordings. In this study we used these methods to determine if @entity1540 induced during @entity955 were followed by compensatory pauses. Five @entity1 were studied who had ECGs with a normal PR interval and a normal QRS duration and morphology during sinus rhythm. @entity955 was induced by rapid atrial pacing. @entity1540 were induced by coupling a ventricular extrastimulus to every eighth or tenth QRS complex during @entity955 . The coupling interval of the PVC was changed in 10- or 20-msec increments until the entire cardiac cycle was scanned. The mean duration of recorded @entity955 was 15.7 minutes. Fifty-seven to 163 @entity1540 were induced in each @entity1 . The mean cycle after the induced PVC was calculated and compared with the mean control cycle. The mean cycle after the PVC was 107-136 msec longer than the mean control cycle (p < 0.001 in every @entity1 ). This study confirms the presence of a compensatory pause after stimulated @entity1540 in @entity955 .

title: The "compensatory pause" of XXXX .

entities_list: @entity1540 :: ('MESH:D018879', 'Disease') :: ['premature ventricular complexes', 'PVCs']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'Atrial fibrillation']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: @entity1 with @entity1555 ( @entity1555 ) usually have a @entity296 characterized by @entity82 of the epicardial half of the left ventricle. This @entity296 is difficult to detect by noninvasive techniques. We report a technique that evaluates incremental left ventricular posterior wall thickening and thinning. High-quality left ventricular posterior wall echoes in 24 @entity1 with @entity1555 and 32 controls were recorded at chordal level two times 1 year apart. Endocardial and epicardial echoes and a timing ECG were digitized and analyzed by minicomputer. Left ventricular wall amplitudes were determined at standardized temporal increments during contraction and relaxation. To compare with this left ventricular assessment technique, systolic ejection times, shortening fraction and mean velocity of circumferenial fiber shortening (Vcf) were also computed in the standard way. Mean year-to-year changes were minor. Mean Vcf, the ratio of preejection period to left ventricular ejection time and shortening fraction during the first year were statistically similar to those of the controls. Shortening fraction decreased slightly during the second year and became significantly different from the control, but remained within the normal range. Left ventricular wall thickness and cavity size were significantly less in @entity1 with @entity1555 than in controls. Therefore, we had to normalize incremental wall thickness to determine if any significant difference occurred. To do this, we evaluated the percentage of maximal wall thickness which occurred at a given percent of systole and diastole. Using this technique, it was shown that thickening during systole was a nearly linear process with respect to time in both groups. However, relaxation was significantly different between the groups. Relaxation was found to be an alinear process, and most thinning occurred in the first 40% of diastole. The major findings of this investigation was that the left ventricular wall of @entity1 with @entity1555 thinned at a slower rate than that of normal subjects. This new technique appears to be sensitive and demonstrates subtle changes in the left ventricular posterior wall.

title: Echocardiographic determination of contraction and relaxation measurements of the left ventricular wall in normal subjects and XXXX with muscular dystrophy.

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ["Duchenne's muscular dystrophy", 'DMD']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Mature Merino rams were made @entity1375 by daily oral drenching with @entity72897 or @entity1378 by daily subcutaneous injections of thyroxine for 8 weeks. Neither @entity1375 nor @entity1378 had any apparent effect on either spermatogenesis or daily sperm production, but motility of ejaculated spermatozoa and circulating @entity251 concentrations were reduced in both conditions. The ratio of @entity251 concentrations in plasma from the internal spermatic vein to those in peripheral blood plasma was higher in @entity1378 (21.2 +/- 3.5) than in control (11.1 +/- 4.4) and @entity1375 (7.6 +/- 1.4) rams. The basal secretion rate for @entity251 was slightly lower in @entity1375 rams and @entity251 responses to @entity1 chorionic gonadotrophin and after @entity4396 ( @entity4396 ) were very much reduced. Basal serum LH levels were low in both @entity1375 and @entity1378 rams compared with controls whereas there were no differences in FSH levels. The LH response to exogenous @entity4396 was reduced in @entity1375 rams but not in @entity1378 rams. Serum prolactin levels on the other hand were higher than control in both @entity1375 and @entity1378 rams. Reduced @entity251 secretion in @entity1375 rams indicates that the normal function of Leydig cells depends on an adequate level of thyroid hormones. The decrease in circulating @entity251 concentrations in @entity1378 rams with normal secretion rates suggests an increased @entity251 clearance rate in these animals. The @entity1319 in hypo- and @entity1378 rams suggests that the lowered @entity251 level in these animals has altered the @entity342 -dependent maturation of spermatozoa in the epididymis.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Spermatogenesis, seminal characteristics and reproductive hormone levels in mature rams with induced @entity1375 and XXXX .

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism', 'hypothyroid']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity4396 :: ('2796', 'Gene') :: ['LHRH', 'LH-releasing hormone']

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism', 'hyperthyroid']

entities_list: @entity72897 :: ('MESH:D008779', 'Chemical') :: ['methylthiouracil']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity1319 :: ('MESH:D015835', 'Disease') :: ['decreased spermatozoal motility']

answer: @entity1378 :: (MESH:D006980,Disease) :: ['hyperthyroidism']


abstract: Mature Merino rams were made @entity1375 by daily oral drenching with @entity72897 or @entity1378 by daily subcutaneous injections of thyroxine for 8 weeks. Neither @entity1375 nor @entity1378 had any apparent effect on either spermatogenesis or daily sperm production, but motility of ejaculated spermatozoa and circulating @entity251 concentrations were reduced in both conditions. The ratio of @entity251 concentrations in plasma from the internal spermatic vein to those in peripheral blood plasma was higher in @entity1378 (21.2 +/- 3.5) than in control (11.1 +/- 4.4) and @entity1375 (7.6 +/- 1.4) rams. The basal secretion rate for @entity251 was slightly lower in @entity1375 rams and @entity251 responses to @entity1 chorionic gonadotrophin and after @entity4396 ( @entity4396 ) were very much reduced. Basal serum LH levels were low in both @entity1375 and @entity1378 rams compared with controls whereas there were no differences in FSH levels. The LH response to exogenous @entity4396 was reduced in @entity1375 rams but not in @entity1378 rams. Serum prolactin levels on the other hand were higher than control in both @entity1375 and @entity1378 rams. Reduced @entity251 secretion in @entity1375 rams indicates that the normal function of Leydig cells depends on an adequate level of thyroid hormones. The decrease in circulating @entity251 concentrations in @entity1378 rams with normal secretion rates suggests an increased @entity251 clearance rate in these animals. The @entity1319 in hypo- and @entity1378 rams suggests that the lowered @entity251 level in these animals has altered the @entity342 -dependent maturation of spermatozoa in the epididymis.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Spermatogenesis, seminal characteristics and reproductive hormone levels in mature rams with induced XXXX and @entity1378 .

answer: @entity1375 :: (MESH:D007037,Disease) :: ['hypothyroidism']


abstract: The purpose of this study was to evaluate therapy with @entity3601 , @entity1487 ( @entity1487 ), and @entity11796 combination (MFP) in @entity1 with metastatic or recurrent @entity1204 not amenable to surgery or radiation therapy, as compared to @entity1420 therapy alone. Previously, the authors have treated 114 @entity1 with @entity1420 therapy and achieved a 15.8% objective response rate; 7.0% were complete responders. Thirteen @entity1 with documented recurrent or metastatic @entity1204 were entered into the MFP study. Thirteen were evaluable for @entity137 and 11 for response (2 had no measureable parameter). Treatment consisted of melphalan 0.2 mg/kg/day for 4 days every 4 weeks; @entity1487 15 mg/kg/day for 4 days every 4 weeks; and @entity11796 1.0 g intramuscularly weekly. Two of the first 3 @entity1 who were treated with this regimen developed severe @entity882 (platelets, 25,000 and 17,000/mm3). Therefore, the remaining 10 @entity1 received @entity1487 at a dose of 10 mg/kg/day for 4 days every 4 weeks. Except for 1 @entity1 who devloped @entity2268 , there was no other significant @entity137 in the 90 courses of therapy received by the 13 @entity1 . Of the 11 @entity1 evaluable for respone, 6 (54.5%) responded (2 complete responders, 4 partial responders), 2 for stationary disease, and 3 progressed after having had stationary disease for 3, 6, and 9 months, respectively. Of special interest was that the 2 @entity1 with @entity1962 responded and 1 additional @entity1 with @entity420 maintained a complete response with @entity1487 therapy alone.

title: Melphalan, @entity1487 , and XXXX in metastatic or recurrent @entity1204 . Preliminary report.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity2268 :: ('MESH:D013924', 'Disease') :: ['thrombophlebitis']

entities_list: @entity3601 :: ('MESH:D008558', 'Chemical') :: ['melphalan']

entities_list: @entity1962 :: ('MESH:D018196', 'Disease') :: ['adenosquamous carcinoma']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity11796 :: (MESH:D017258,Chemical) :: ['medroxyprogesterone acetate']


abstract: The purpose of this study was to evaluate therapy with @entity3601 , @entity1487 ( @entity1487 ), and @entity11796 combination (MFP) in @entity1 with metastatic or recurrent @entity1204 not amenable to surgery or radiation therapy, as compared to @entity1420 therapy alone. Previously, the authors have treated 114 @entity1 with @entity1420 therapy and achieved a 15.8% objective response rate; 7.0% were complete responders. Thirteen @entity1 with documented recurrent or metastatic @entity1204 were entered into the MFP study. Thirteen were evaluable for @entity137 and 11 for response (2 had no measureable parameter). Treatment consisted of melphalan 0.2 mg/kg/day for 4 days every 4 weeks; @entity1487 15 mg/kg/day for 4 days every 4 weeks; and @entity11796 1.0 g intramuscularly weekly. Two of the first 3 @entity1 who were treated with this regimen developed severe @entity882 (platelets, 25,000 and 17,000/mm3). Therefore, the remaining 10 @entity1 received @entity1487 at a dose of 10 mg/kg/day for 4 days every 4 weeks. Except for 1 @entity1 who devloped @entity2268 , there was no other significant @entity137 in the 90 courses of therapy received by the 13 @entity1 . Of the 11 @entity1 evaluable for respone, 6 (54.5%) responded (2 complete responders, 4 partial responders), 2 for stationary disease, and 3 progressed after having had stationary disease for 3, 6, and 9 months, respectively. Of special interest was that the 2 @entity1 with @entity1962 responded and 1 additional @entity1 with @entity420 maintained a complete response with @entity1487 therapy alone.

title: Melphalan, XXXX , and @entity11796 in metastatic or recurrent @entity1204 . Preliminary report.

answer: @entity1487 :: (MESH:D005472,Chemical) :: ['5-fluorouracil']


abstract: The purpose of this study was to evaluate therapy with @entity3601 , @entity1487 ( @entity1487 ), and @entity11796 combination (MFP) in @entity1 with metastatic or recurrent @entity1204 not amenable to surgery or radiation therapy, as compared to @entity1420 therapy alone. Previously, the authors have treated 114 @entity1 with @entity1420 therapy and achieved a 15.8% objective response rate; 7.0% were complete responders. Thirteen @entity1 with documented recurrent or metastatic @entity1204 were entered into the MFP study. Thirteen were evaluable for @entity137 and 11 for response (2 had no measureable parameter). Treatment consisted of melphalan 0.2 mg/kg/day for 4 days every 4 weeks; @entity1487 15 mg/kg/day for 4 days every 4 weeks; and @entity11796 1.0 g intramuscularly weekly. Two of the first 3 @entity1 who were treated with this regimen developed severe @entity882 (platelets, 25,000 and 17,000/mm3). Therefore, the remaining 10 @entity1 received @entity1487 at a dose of 10 mg/kg/day for 4 days every 4 weeks. Except for 1 @entity1 who devloped @entity2268 , there was no other significant @entity137 in the 90 courses of therapy received by the 13 @entity1 . Of the 11 @entity1 evaluable for respone, 6 (54.5%) responded (2 complete responders, 4 partial responders), 2 for stationary disease, and 3 progressed after having had stationary disease for 3, 6, and 9 months, respectively. Of special interest was that the 2 @entity1 with @entity1962 responded and 1 additional @entity1 with @entity420 maintained a complete response with @entity1487 therapy alone.

title: Melphalan, @entity1487 , and @entity11796 in metastatic or recurrent XXXX . Preliminary report.

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial carcinoma']


abstract: OBJECTIVE: To study the relationship between long-term high-salt hot diet and chronic @entity4726 (CAG). The expression of apoptosis cells, proliferation cells, @entity588 and Fas proteins were detected in the @entity356 of CAG rates induced by high-salt hot water. METHODS: TUNEL technique and immunohistochemical method were used in the experiment. Flow cytometry method was used to detect the DNA content of apoptosis cells. RESULTS: (1) The detection of apoptosis with TUNEL showed that the apoptosis cells in CAG rates induced by high-salt hot water were high. These cells could be seen in all layers of @entity356 , apoptosis index of model rates was higher than that of normal rates (P < 0.05). (2) The result of detecting apoptosis gene and @entity1364 ( @entity1364 ) by immunohistochemical method showed that the expression of @entity588 , Fas and @entity1364 in the CAG rates induced by high-salt hot water was much higher than that of normal @entity356 (P < 0.05). The expression rates of @entity588 , Fas proteins were higher with time going on. After being given high-salt hot water intragastrically for 4, 8, 12 weeks, the @entity588 protein expression rates were 12.5%, 16.7%, 76.5%, the Fas protein expression rates were 18.7%, 22.2% and 64.7%. (3) Flow cytometry technique showed that there was a second G(0)/G(1) peek, which was apoptosis cells peak, but was not seen in the normal @entity356 . CONCLUSIONS: Abnormality of proliferation and apoptosis in @entity356 could be induced by high-salt hot water. @entity588 , Fas gene played an important role in this course.

title: [Experimental study of apoptosis and proliferation of XXXX in chronic @entity4726 ].

entities_list: @entity4726 :: ('MESH:D005757', 'Disease') :: ['atrophic gastritis']

entities_list: @entity1364 :: ('5111', 'Gene') :: ['proliferating cell nuclear antigen', 'PCNA']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric mucosa']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric mucosal cells']