abstract: UNASSIGNED: Background: Severe @entity221 with @entity882 (SFTS) is a newly emerging @entity166 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity1 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity404 +/total lymphocytes, @entity404 + @entity2902 +/ @entity404 + cells and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells was observed in @entity1 with SFTS compared with healthy controls. In contrast, the percentage of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in the @entity1 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity1 with SFTS at different stages. The results showed that the proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells in the non-severe group was prominently higher than that in @entity1 with severe SFTS. Conversely, the proportion of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity1 with SFTS. Our investigation suggested that the proportions of @entity404 +/total lymphocytes and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.

title: Circulating regulatory T cells in @entity1 with severe XXXX with @entity882 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia syndrome']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']

answer: @entity221 :: (MESH:D005334,Disease) :: ['fever']


abstract: UNASSIGNED: Background: Severe @entity221 with @entity882 (SFTS) is a newly emerging @entity166 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity1 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity404 +/total lymphocytes, @entity404 + @entity2902 +/ @entity404 + cells and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells was observed in @entity1 with SFTS compared with healthy controls. In contrast, the percentage of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in the @entity1 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity1 with SFTS at different stages. The results showed that the proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells in the non-severe group was prominently higher than that in @entity1 with severe SFTS. Conversely, the proportion of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity1 with SFTS. Our investigation suggested that the proportions of @entity404 +/total lymphocytes and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.

title: Circulating regulatory T cells in @entity1 with severe @entity221 with XXXX .

answer: @entity882 :: (MESH:D013921,Disease) :: ['thrombocytopenia syndrome']


abstract: UNASSIGNED: Background: Severe @entity221 with @entity882 (SFTS) is a newly emerging @entity166 caused by SFTS virus (SFTSV). Immunologic factors have been proved to be related to the occurrence and development of SFTS; however, their role still remains to be further elucidated. Methods: Samples from 30 @entity1 with laboratory-confirmed SFTS and 15 healthy controls were subjected to flow cytometry to detect the proportion of @entity404 +/total lymphocytes, @entity404 + @entity2902 +/ @entity404 + cells and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood and to evaluate their potential function in the development of SFTS. Results: The data showed that a reduced proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells was observed in @entity1 with SFTS compared with healthy controls. In contrast, the percentage of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in the @entity1 in the SFTS group was significantly elevated. Furthermore, we investigated the dynamic changes of the circulating regulatory T cells (Tregs) in @entity1 with SFTS at different stages. The results showed that the proportion of @entity404 +/total lymphocytes and @entity404 + @entity2902 +/ @entity404 + cells in the non-severe group was prominently higher than that in @entity1 with severe SFTS. Conversely, the proportion of @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells was lower in the non-severe group than in the severe group. Additionally, the circulating Tregs reverted to normal ranges during the convalescent phase of SFTSV infection. Moreover, the Tregs level correlated with various clinical parameters. Conclusion: We demonstrated that SFTSV infection resulted in a robust circulating Treg response in @entity1 with SFTS. Our investigation suggested that the proportions of @entity404 +/total lymphocytes and @entity404 + @entity2902 + @entity403 +/ @entity404 + @entity2902 + cells in circulating blood could serve as sensitive indices to evaluate the changes in Tregs in SFTS and predict the progression of SFTS.

title: Circulating regulatory T cells in XXXX with severe @entity221 with @entity882 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: @entity1957 ( @entity1957 ) is assumed to enhance poststroke motor recovery, yet its benefits are debatable. Brain-computer interfaces (BCIs) can provide instantaneous and quantitative measure of cerebral functions modulated by @entity1957 . The efficacy of BCI-monitored @entity1957 practice as add-on intervention to usual rehabilitation care was evaluated in a randomized controlled pilot study in subacute @entity64 @entity1 . METHODS: Twenty-eight hospitalized subacute @entity64 @entity1 with severe motor deficits were randomized into 2 intervention groups: 1-month BCI-supported @entity1957 training (BCI group, n   =   14) and 1-month @entity1957 training without BCI support (control group; n   =   14). Functional and neurophysiological assessments were performed before and after the interventions, including evaluation of the upper limbs by Fugl-Meyer Assessment (FMA; primary outcome measure) and analysis of oscillatory activity and connectivity at rest, based on high-density electroencephalographic (EEG) recordings. RESULTS: Better functional outcome was observed in the BCI group, including a significantly higher probability of achieving a clinically relevant increase in the FMA score (p   <   0.03). Post-BCI training changes in EEG sensorimotor power spectra (ie, stronger desynchronization in the alpha and beta bands) occurred with greater involvement of the ipsilesional hemisphere in response to @entity1957 of the paralyzed trained hand. Also, FMA improvements (effectiveness of FMA) correlated with the changes (ie, post-training increase) at rest in ipsilesional intrahemispheric connectivity in the same bands (p   <   0.05). INTERPRETATION: The introduction of BCI technology in assisting @entity1957 practice demonstrates the rehabilitative potential of @entity1957 , contributing to significantly better motor functional outcomes in subacute @entity64 @entity1 with severe @entity73 . Ann Neurol 2015.

title: Brain-computer interface boosts motor imagery practice during XXXX recovery.

entities_list: @entity1957 :: ('MESH:D019957', 'Disease') :: ['Motor imagery', 'MI']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['motor impairments']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: UNASSIGNED: @entity6 is a chronic @entity209 accompanied by several comorbidities, including neuropsychiatric conditions. Since the @entity4854 appears to be the primary factor involved in @entity6 conditions, we examined the effect of insulin treatment in @entity6 @entity35 on behavioral responses related to @entity148 and aversive memory extinction. For this, normoglycemic (NGL) or @entity3839 - @entity6 (DBT) @entity35 were submitted to the elevated T maze (ETM) and the contextual conditioned fear (CCF) tests. Therefore, animals were subjected to the prolonged treatment with insulin (6  IU/day, s.c.) to investigate the effect of the treatment on distinct behaviors. When @entity148 -like responses such as the inhibitory avoidance (IA) on the ETM and the time of freezing in the first session of the CCF test were evaluated, our data showed a more pronounced anxiogenic-like behavior in DBT animals when compared to NGL ones. In addition, an increased freezing time was observed in DBT animals exposed to the CCF test (sessions 2 and 3) when compared to the NGL group, suggestive of an impairment in the extinction of aversive memory. Insulin treatment induced an anxiolytic-like effect when IA and freezing time (session 1) was evaluated, but did not alter the impaired extinction of aversive memory (sessions 2 and 3). To better understand the involvement of a rigorous control of glycaemia, we also investigated the effect of a lower dose of insulin (3  IU/day, s.c.), unable to reestablish the @entity4854 to the normal levels, on the same behavioral parameters. Our data show that independent of the dose of insulin, the same effects were observed when animals were evaluated in the ETM and CCF tests. However, only the highest dose of insulin was able to reduce the @entity4854 to the normal levels. To conclude, our data suggest that a severe glycemic control by insulin treatment seems to be important, but not essential in improving @entity6 -induced @entity148 .

title: Reestablishment of the XXXX to the normal levels seems not to be essential to the anxiolytic-like effect induced by insulin.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetic', 'diabetes']

entities_list: @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disease']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

answer: @entity4854 :: (MESH:D006943,Disease) :: ['hyperglycemia']


abstract: BACKGROUND: Survival rates are commonly used to measure success in treating @entity5 , but can be misleading. Modern diagnostic practices can lead to the appearance of improving @entity5 survival, as @entity5 are diagnosed earlier (lead-time bias) or as an increasing proportion are slow-growing (length bias), whereas the actual burden of @entity5 deaths is unchanged. Increasingly, more @entity259 are being diagnosed. The objective of the current study was to determine whether @entity259 survival rates have been affected by this phenomenon. METHODS: The authors analyzed survival data from @entity1 with @entity259 who were treated at Memorial Sloan Kettering @entity5 Center (MSKCC) from 1950 to 2005, and United States population-based incidence, prevalence, and survival data from 1973 to 2009 in the Surveillance, Epidemiology, and End Results data set. RESULTS: US @entity259 incidence has increased 3-fold from 1975 to 2009. Over time, the proportion of @entity259 that are subcentimeter in size has increased from 23% (1983) to 36% (2009). At MSKCC, this percentage rose from 20% (1950) to 35% (2005). The incidence rates of large @entity5 (>6 cm) and distant metastasis have not changed. In the United States, 10-year relative survival improved from 95.4% to 98.6% (1983-1999). At MSKCC, 10-year disease-specific survival improved from 91.1% to 96.1% (1950-2005). However, when stratified by @entity5 size and stage, no changes in survival outcomes were observed. US @entity259 mortality rates have remained stable (1975-2009). CONCLUSIONS: Modern medical practices increasingly uncover small, asymptomatic @entity259 . Survival rates appear improved, but this finding is spurious, attributable instead to shifts in the characteristics of disease being diagnosed. Relying on survival rates to measure success in treating @entity259 may reinforce inappropriately aggressive management. Treatment decisions in @entity259 should be made based on mortality, not survival data. @entity5 2015.    2014 American @entity5 Society.

title: Increasing diagnosis of XXXX leads to spurious improvements in survival rates.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer', 'tumors']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['subclinical thyroid cancers', 'thyroid cancers', 'thyroid cancer']

answer: @entity259 :: (MESH:D013964,Disease) :: ['subclinical thyroid cancers']


abstract: UNASSIGNED: @entity14537 ( @entity14537 , @entity19277 #117550) is an @entity21117 . Deletions or intragenic mutations of the @entity14538 , which is located at chromosome 5q35, are responsible for more than 75% of @entity14537 . Conventionally, @entity4053 was reported briefly as one of the infrequent symptoms of @entity14537 . However, Matsuo et al. published a report describing five @entity1 with @entity14537 who presented with transient @entity1717 ( @entity1717 ) in the neonatal period. We report on an additional @entity1 of @entity14537 , who presented transient @entity1717 in the neonatal period. All of this @entity1 and previous @entity1 have microdeletions at the 5q35 chromosome. Therefore, we examined the following three in considering the possibility that other factor than @entity14538 caused @entity1717 . 1) This @entity1 had no mutation of four currently known @entity1717 related genes, @entity11773 , @entity14225 , @entity29521 , and GCK. 2) He had no further deletion than commonly observed region encompassing @entity14538 by comparative genomic hybridization to DNA microarrays. 3) He had no mutation in the 5q35 region in the non-deleted chromosome using exsome sequence analysis. In conclusion, our @entity1 supported that @entity1717 could be one of the characteristic symptoms of @entity14537 in the neonatal period, and could be useful for early diagnosis.    2015 Wiley Periodicals, Inc.

title: A case with neonatal XXXX : It is a characteristic complication of sotos syndrome.

entities_list: @entity14537 :: ('MESH:D058495', 'Disease') :: ['SoS', 'Sotos syndrome']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['neonatal hypoglycemia']

entities_list: @entity1717 :: ('MESH:D044903', 'Disease') :: ['HIH', 'hyperinsulinemic hypoglycemia']

entities_list: @entity21117 :: ('MESH:C537340', 'Disease') :: ['overgrowth syndrome']

answer: @entity1717 :: (MESH:D044903,Disease) :: ['hyperinsulinemic hypoglycemia']


abstract: OBJECTIVE: The aim was to evaluate the feasibility and safety of early chest tube removal after complete video-assisted @entity1514 (CVATL). METHODS: Retrospective analysis was performed on effects of chest tube removal on @entity1 with @entity2 after pulmonary lobectomy between November 2013 and October 2014. 154 eligible @entity1 included 97 cases for CVATL and 57 cases for open @entity1514 . @entity1 with CVATL were divided randomly into experimental group (EG) and control group (CG), in which 51 @entity1 in EG had chest tube removal on the 2 nd day after operation; 46 @entity1 in CG had the tube removal when the drainage volume <100 ml/day. @entity1 in open @entity1514 group (OG) had the tubes removal as CG. The drainage volumes of the 1 st and 2 nd 24 h after operation, duration of chest tubes, cases of @entity158 alleviation, and recurrent @entity1143 requiring reintervention were measured. RESULTS: The average drainage volume of the 1 st 24 h after operation of CVATL group from EG and CG was significantly reduced than that in OG (260.41 ml vs. 353.16 ml, P < 0.001). The average drainage volume of the 2 nd 24 h after operation of CG was significantly reduced than that in OG (163.91 ml vs. 222.98 ml, P < 0.001). The average duration of chest tube of CG for 2.98 days showed significant different compared with OG for 3.81 days (P < 0.001). Chest tube removal in CVATL group increased more @entity662 alleviation than OG (80.4% vs. 56.1%, P = 0.001). The frequencies of recurrent @entity1143 requiring reintervention were 5.88% (3/51), 4.35% (2/46) and 5.26% (3/57), respectively, which had no significant differences between three groups (P = 1.000). CONCLUSIONS: Complete video-assisted @entity1514 brings less drainage volume after operation. Early removal of chest tube in CVATL shows feasible and safe and demonstrates that it may reduce @entity282 and help fast recovery.

title: Feasibility and safety of early chest tube removal after complete video-assisted XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['thoracic lobectomy']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

answer: @entity1514 :: (MESH:D013896,Disease) :: ['thoracic lobectomy']


abstract: UNASSIGNED: In a cohort study of 182 consecutive @entity1 with active endogenous @entity699 , the only predictor of @entity174 occurrence after adjustment for age, gender @entity79 ( @entity79 ) and @entity79 ( @entity79 ) was 24-h urinary free @entity701 (24hUFC) levels with a threshold of 1472  nmol/24  h (odds ratio, 3.00 (95  % confidence interval (CI), 1.52-5.92); p   =   0.002). INTRODUCTION: The aim was to estimate the risk factors for @entity174 in subjects with endogenous @entity699 ( @entity699 ) and to evaluate the value of the @entity79 in these @entity1 . METHODS: All enrolled @entity1 with @entity699 (n   =   182) were interviewed in relation to low-traumatic @entity174 and underwent lateral X-ray imaging from T4 to L5. @entity79 measurements were performed using a DXA Prodigy device (GEHC Lunar, Madison, Wisconsin, USA). The @entity79 was derived retrospectively from existing @entity79 scans, blinded to clinical outcome, using @entity79 iNsight software @entity34660 (Medimaps, Merignac, France). Urinary free @entity701 (24hUFC) was measured by immunochemiluminescence assay (reference range, 60-413  nmol/24  h). RESULTS: Among enrolled @entity1 with @entity699 (149 females; 33 males; mean age, 37.8  years (95  % confidence interval, 34.2-39.1); 24hUFC, 2370  nmol/24  h (2087-2632), @entity174 were confirmed in 81 (44.5  %) @entity1 , with 70 suffering from @entity174 , which were multiple in 53 cases; 24 @entity1 reported @entity174 . The mean spine @entity79 was 1.207 (1.187-1.228), and @entity79 Z-score was -1.86 (-2.07 to -1.65); area under the curve (AUC) was used to predict @entity174 (mean spine @entity79 )   =   0.548 (95  % CI, 0.454-0.641)). In the final regression model, the only predictor of @entity174 occurrence was 24hUFC levels (p   =   0.001), with an increase of 1.041 (95  % CI, 1.019-1.063), calculated for every 100  nmol/24-h @entity701 elevation (AUC (24hUFC)   =   0.705 (95  % CI, 0.629-0.782)). CONCLUSIONS: Young @entity1 with @entity699 have a low @entity79 . However, the only predictor of low traumatic @entity174 is the severity of the disease itself, indicated by high 24hUFC levels.

title: The risk factors for XXXX and trabecular bone-score value in @entity1 with endogenous @entity699 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'vertebral fractures', 'non-vertebral fractures', 'fracture']

entities_list: @entity699 :: ('MESH:D003480', 'Disease') :: ['CS', "Cushing's syndrome"]

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD', 'trabecular bone score', 'TBS']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: UNASSIGNED: In a cohort study of 182 consecutive @entity1 with active endogenous @entity699 , the only predictor of @entity174 occurrence after adjustment for age, gender @entity79 ( @entity79 ) and @entity79 ( @entity79 ) was 24-h urinary free @entity701 (24hUFC) levels with a threshold of 1472  nmol/24  h (odds ratio, 3.00 (95  % confidence interval (CI), 1.52-5.92); p   =   0.002). INTRODUCTION: The aim was to estimate the risk factors for @entity174 in subjects with endogenous @entity699 ( @entity699 ) and to evaluate the value of the @entity79 in these @entity1 . METHODS: All enrolled @entity1 with @entity699 (n   =   182) were interviewed in relation to low-traumatic @entity174 and underwent lateral X-ray imaging from T4 to L5. @entity79 measurements were performed using a DXA Prodigy device (GEHC Lunar, Madison, Wisconsin, USA). The @entity79 was derived retrospectively from existing @entity79 scans, blinded to clinical outcome, using @entity79 iNsight software @entity34660 (Medimaps, Merignac, France). Urinary free @entity701 (24hUFC) was measured by immunochemiluminescence assay (reference range, 60-413  nmol/24  h). RESULTS: Among enrolled @entity1 with @entity699 (149 females; 33 males; mean age, 37.8  years (95  % confidence interval, 34.2-39.1); 24hUFC, 2370  nmol/24  h (2087-2632), @entity174 were confirmed in 81 (44.5  %) @entity1 , with 70 suffering from @entity174 , which were multiple in 53 cases; 24 @entity1 reported @entity174 . The mean spine @entity79 was 1.207 (1.187-1.228), and @entity79 Z-score was -1.86 (-2.07 to -1.65); area under the curve (AUC) was used to predict @entity174 (mean spine @entity79 )   =   0.548 (95  % CI, 0.454-0.641)). In the final regression model, the only predictor of @entity174 occurrence was 24hUFC levels (p   =   0.001), with an increase of 1.041 (95  % CI, 1.019-1.063), calculated for every 100  nmol/24-h @entity701 elevation (AUC (24hUFC)   =   0.705 (95  % CI, 0.629-0.782)). CONCLUSIONS: Young @entity1 with @entity699 have a low @entity79 . However, the only predictor of low traumatic @entity174 is the severity of the disease itself, indicated by high 24hUFC levels.

title: The risk factors for @entity174 and trabecular bone-score value in @entity1 with endogenous XXXX .

answer: @entity699 :: (MESH:D003480,Disease) :: ['Cushing's syndrome']


abstract: UNASSIGNED: In a cohort study of 182 consecutive @entity1 with active endogenous @entity699 , the only predictor of @entity174 occurrence after adjustment for age, gender @entity79 ( @entity79 ) and @entity79 ( @entity79 ) was 24-h urinary free @entity701 (24hUFC) levels with a threshold of 1472  nmol/24  h (odds ratio, 3.00 (95  % confidence interval (CI), 1.52-5.92); p   =   0.002). INTRODUCTION: The aim was to estimate the risk factors for @entity174 in subjects with endogenous @entity699 ( @entity699 ) and to evaluate the value of the @entity79 in these @entity1 . METHODS: All enrolled @entity1 with @entity699 (n   =   182) were interviewed in relation to low-traumatic @entity174 and underwent lateral X-ray imaging from T4 to L5. @entity79 measurements were performed using a DXA Prodigy device (GEHC Lunar, Madison, Wisconsin, USA). The @entity79 was derived retrospectively from existing @entity79 scans, blinded to clinical outcome, using @entity79 iNsight software @entity34660 (Medimaps, Merignac, France). Urinary free @entity701 (24hUFC) was measured by immunochemiluminescence assay (reference range, 60-413  nmol/24  h). RESULTS: Among enrolled @entity1 with @entity699 (149 females; 33 males; mean age, 37.8  years (95  % confidence interval, 34.2-39.1); 24hUFC, 2370  nmol/24  h (2087-2632), @entity174 were confirmed in 81 (44.5  %) @entity1 , with 70 suffering from @entity174 , which were multiple in 53 cases; 24 @entity1 reported @entity174 . The mean spine @entity79 was 1.207 (1.187-1.228), and @entity79 Z-score was -1.86 (-2.07 to -1.65); area under the curve (AUC) was used to predict @entity174 (mean spine @entity79 )   =   0.548 (95  % CI, 0.454-0.641)). In the final regression model, the only predictor of @entity174 occurrence was 24hUFC levels (p   =   0.001), with an increase of 1.041 (95  % CI, 1.019-1.063), calculated for every 100  nmol/24-h @entity701 elevation (AUC (24hUFC)   =   0.705 (95  % CI, 0.629-0.782)). CONCLUSIONS: Young @entity1 with @entity699 have a low @entity79 . However, the only predictor of low traumatic @entity174 is the severity of the disease itself, indicated by high 24hUFC levels.

title: The risk factors for @entity174 and trabecular bone-score value in XXXX with endogenous @entity699 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: @entity418 is a poor-prognosis malignancy that ranks eighth among all @entity5 types, and its prevalence shows differences among geographical regions. Although the most important risk factors for @entity418 are @entity285 and smoking, @entity1800 , particularly @entity281 , are also considered among etiological agents. Our study aims to detect the presence of @entity418 in our @entity1 population and to investigate its correlation with clinico-pathological parameters. We investigated the presence of HPV-DNA by real-time polymerase chain reaction in a total of 52 @entity1 with @entity418 . Subtype analysis was performed in positive cases and was correlated with selected clinico-pathological parameters. Five (9.6%) of 52 @entity5 samples, 3 @entity957 (3/33 cases) and 2 @entity420 (2/19 cases), were HPV-DNA-positive. Subtype analysis could be performed in four HPV-DNA-positive cases, of which three were HPV type-39 and 1 was type-16. The Marmara region, where the present study was carried out, is a region with low-moderate risk for @entity418 , and the prevalence of HPV-DNA in these @entity5 is similar to the prevalence of HPV-DNA reported in the literature for regions with similar risk. In conclusion, we detected HPV DNA in a subset of esophageal and @entity5 . @entity281 may have a role in esophageal @entity105 and high-risk HPV subtypes can particularly be considered among risk factors since the prevalence of high risk @entity281 has also been found to be increased in regions with a high risk for @entity418 compared to low-moderate risk regions.

title: Detection of human papillomavirus in esophageal and XXXX : A retrospective study by real-time polymerase chain reaction in an instutional experience from Turkey and review of literature.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'gastroesophageal junction tumors', 'cancer', 'tumors']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['HPV infection']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infections']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['Esophageal cancer', 'esophageal cancer', 'HPV in esophageal cancers', 'esophageal carcinoma']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinomas']

answer: @entity5 :: (MESH:D009369,Disease) :: ['gastroesophageal junction tumors']


abstract: OBJECTIVE: @entity1593 ( @entity1593 ) is the only management for @entity66 ( @entity66 ). Available methods to assess @entity1593 compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause @entity16 . We aimed to develop a method to determine gluten intake and monitor @entity1593 compliance in @entity1 with @entity66 and to evaluate its correlation with @entity16 . DESIGN: Urine samples of 76 healthy subjects and 58 @entity1 with @entity66 subjected to different gluten dietary conditions were collected. A lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant gluten immunogenic peptides (GIP) and a LFT reader were used to quantify GIP in solid-phase extracted urines. RESULTS: GIP were detectable in concentrated urines from healthy individuals previously subjected to @entity1593 as early as 4-6   h after single gluten intake, and remained detectable for 1-2   days. The urine assay revealed infringement of the @entity1593 in about 50% of the @entity1 . Analysis of duodenal biopsies revealed that most of @entity1 with @entity66 (89%) with no villous @entity194 had no detectable GIP in urine, while all @entity1 with quantifiable GIP in urine showed incomplete intestinal mucosa recovery. CONCLUSION: GIP are detected in urine after gluten consumption, enabling a new and non-invasive method to monitor @entity1593 compliance and transgressions. The method was sensitive, specific and simple enough to be convenient for clinical monitoring of @entity1 with @entity66 as well as for basic and clinical research applications including drug development. TRIAL REGISTRATION NUMBER: NCT02344758.

title: Detection of gluten immunogenic peptides in the urine of @entity1 with XXXX reveals transgressions in the gluten-free diet and incomplete mucosal healing.

entities_list: @entity1593 :: ('MESH:D002446', 'Disease') :: ['GFD', 'Gluten-free diet']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['coeliac disease', 'CD']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['mucosal damage', 'gut mucosal damage']

answer: @entity66 :: (MESH:D004194,Disease) :: ['coeliac disease']


abstract: OBJECTIVE: @entity1593 ( @entity1593 ) is the only management for @entity66 ( @entity66 ). Available methods to assess @entity1593 compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause @entity16 . We aimed to develop a method to determine gluten intake and monitor @entity1593 compliance in @entity1 with @entity66 and to evaluate its correlation with @entity16 . DESIGN: Urine samples of 76 healthy subjects and 58 @entity1 with @entity66 subjected to different gluten dietary conditions were collected. A lateral flow test (LFT) with the highly sensitive and specific G12 monoclonal antibody for the most dominant gluten immunogenic peptides (GIP) and a LFT reader were used to quantify GIP in solid-phase extracted urines. RESULTS: GIP were detectable in concentrated urines from healthy individuals previously subjected to @entity1593 as early as 4-6   h after single gluten intake, and remained detectable for 1-2   days. The urine assay revealed infringement of the @entity1593 in about 50% of the @entity1 . Analysis of duodenal biopsies revealed that most of @entity1 with @entity66 (89%) with no villous @entity194 had no detectable GIP in urine, while all @entity1 with quantifiable GIP in urine showed incomplete intestinal mucosa recovery. CONCLUSION: GIP are detected in urine after gluten consumption, enabling a new and non-invasive method to monitor @entity1593 compliance and transgressions. The method was sensitive, specific and simple enough to be convenient for clinical monitoring of @entity1 with @entity66 as well as for basic and clinical research applications including drug development. TRIAL REGISTRATION NUMBER: NCT02344758.

title: Detection of gluten immunogenic peptides in the urine of XXXX with @entity66 reveals transgressions in the gluten-free diet and incomplete mucosal healing.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION. The term adoption or adoptive filiation is understood as referring to the legal act by which family ties are created between two @entity1 such that a relationship of fatherhood or motherhood is established between them. AIMS. The purpose of this study is to outline the problems derived from prenatal exposure to @entity167 and other risk factors, from hypostimulation during the 'critical period' in institutionalised @entity1 (especially those adopted from eastern European countries) and their relation with @entity71 ( @entity71 ). This work also seeks to take a deeper look into the diagnosis, prevention and treatment of these problems. DEVELOPMENT. These @entity1 have problems in terms of psychosocial relationships, behavioural problems, delayed language or reading development and, above all, @entity71 . In practice it is extremely difficult to separate the two factors during the assessment of @entity1 adopted from eastern European countries in neuropaediatric consultations. Exactly how all these factors are interrelated is not well understood. CONCLUSIONS. There is a close relationship between prenatal exposure to @entity167 and the consequences of adoption. There is a need for placebo-controlled randomised studies, with larger population samples, that test the benefits and profile of side effects, both with psychostimulants and with @entity4678 in this group of @entity1 .

title: [Attention XXXX and adoption].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'persons']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity4678 :: ('MESH:C041930', 'Chemical') :: ['atomoxetine']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['ADHD', 'attention deficit hyperactivity disorder']

answer: @entity71 :: (MESH:D001289,Disease) :: ['deficit hyperactivity disorder']


abstract: OBJECTIVE: The objective was to explore the determinants of menstrual hygienic practices and its effect on @entity5860 ( @entity5860 ) among ever married @entity1 in India. METHODS: District Level Household and Facility Survey-3 (DLHS) India data have been used in the study. The respondents constituted ever married @entity1 (N   =   577,758) in the age group of 15-49. Bivariate and multivariate techniques were employed using IBM SPSS statistics 20. Individual effects of socio economic, demographic and gynecological factors on menstrual hygienic practices, RTIs and abnormal vaginal discharged respectively were calculated using binary logistic regression. RESULTS: A meager 15% of @entity1 used sanitary pad/locally prepared napkins during menstruation in India. Both @entity5860 and Vaginal discharge were positively related with non-use of hygienic methods. The @entity1 who used unhygienic method during menstruation were more likely to have any symptom of @entity5860 (OR   =   1.046, p   <   0.001, CI   =   1.021-1.071) and vaginal discharge (OR   =   1.303, p   <   0.001, CI   =   1.266-1.341). CONCLUSION: The reason for the symptoms of @entity5860 may be diverse and not only limited to the unhygienic menstrual practices although this may be one of the reasons causing reproductive morbidity. Awareness, affordability and privacy are some of the major concerns that need immediate attention to promote the use of sanitary pad during the time of menstruation. Establishing relation between menstrual practices and @entity5860 is in its initial stage of investigation and hence needs further research.

title: Menstrual hygiene practices and its association with reproductive tract infections and abnormal vaginal discharge among XXXX in India.

entities_list: @entity5860 :: ('MESH:D060737', 'Disease') :: ['Reproductive Tract Infections', 'RTI']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: INTRODUCTION. The difficulties that @entity1 with @entity71 ( @entity71 ) have when it comes to emotional regulation have aroused a great deal of interest in recent years and there is a line of research working on the identification of the neurophysiological correlates. AIMS. To analyse measures of emotional functioning and their correlation with the @entity3493 component in a sample of @entity1 with @entity71 with and without treatment. @entity1 AND METHODS. The sample was made up of 71 @entity1 with @entity71 , almost half of whom were taking some form of medication. The auditory potential @entity3493 was analysed. The parents filled in a scale to assess executive behaviour at home, the Behavior Rating Inventory of Executive Function (BRIEF), which the emotional self-regulation index and the emotional expression scale were taken from. RESULTS. Significant correlations were found between the amplitude of the @entity3493 and the emotional self-regulation index from the version of the BRIEF for preschoolers, and a relation was observed between @entity3493 latency and the severity of the symptoms. CONCLUSIONS. The results highlight the usefulness of evoked potentials for the study of executive correlates and associated conditions in the day-to-day functioning of @entity1 with @entity71 .

title: [Emotional self-regulation in infantile XXXX and @entity3493 evoked potentials].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS']

answer: @entity71 :: (MESH:D001289,Disease) :: ['attention deficit hyperactivity disorder']


abstract: INTRODUCTION. The difficulties that @entity1 with @entity71 ( @entity71 ) have when it comes to emotional regulation have aroused a great deal of interest in recent years and there is a line of research working on the identification of the neurophysiological correlates. AIMS. To analyse measures of emotional functioning and their correlation with the @entity3493 component in a sample of @entity1 with @entity71 with and without treatment. @entity1 AND METHODS. The sample was made up of 71 @entity1 with @entity71 , almost half of whom were taking some form of medication. The auditory potential @entity3493 was analysed. The parents filled in a scale to assess executive behaviour at home, the Behavior Rating Inventory of Executive Function (BRIEF), which the emotional self-regulation index and the emotional expression scale were taken from. RESULTS. Significant correlations were found between the amplitude of the @entity3493 and the emotional self-regulation index from the version of the BRIEF for preschoolers, and a relation was observed between @entity3493 latency and the severity of the symptoms. CONCLUSIONS. The results highlight the usefulness of evoked potentials for the study of executive correlates and associated conditions in the day-to-day functioning of @entity1 with @entity71 .

title: [Emotional self-regulation in infantile @entity71 and XXXX evoked potentials].

answer: @entity3493 :: (2033,Gene) :: ['P300']


abstract: UNASSIGNED: Background: Although several authors have studied the association between @entity4616 ( @entity4616 ) and @entity64 , the matter is still controversial; few have suggested an association between cryptogenetic @entity64 and @entity4616 , while others have denied this association. The aim of this study was to evaluate @entity4616 prevalence in the whole @entity64 population, independently from age and @entity64 subtypes and to identify the characteristics associated with the presence of @entity4616 . Methods: SISIFO study was a multicenter, prospective, single-wave, cross-sectional survey conducted on consecutive @entity1 with acute @entity385 admitted to selected clinical centres. Data regarding vascular risk factors were registered for each @entity1 ; all @entity1 underwent computed tomography scan and/or magnetic resonance imaging of the brain; an electrocardiogram and standard laboratory blood tests were performed. A Doppler ultrasound study of extra-cranial arteries was performed too. The cases were classified according to TOAST and OCSP criteria. Each @entity1 underwent transcranial Doppler or transcranial color-coded duplex sonography with bubble test as diagnostic tool for right-to-left-shunt. Where right-to-left shunt was detected, @entity4616 presence was confirmed by echocardiography. Findings: 1,130 consecutive @entity1 were included. We found a @entity4616 in 247 (21.9%; 95% CI, 19.5-24.3%) @entity1 ; @entity4616 was present in 23.5% of @entity1 with cryptogenic @entity64 and in 21.3% of @entity1 with @entity64 of known causes; this difference was not statistically significant. At the univariate analysis, decreasing age, @entity101 , @entity6 , and @entity955 , and @entity64 characteristics such as NIHSS, OCSP and TOAST were predictors of @entity4616 presence. At the multivariate analysis, we found a significant interaction between age and OCSP syndrome. Being LACI the reference category, the prevalence of @entity4616 in PACI and POCI decreased significantly along with age, whereas there was no change in @entity24603 . Conclusion: If any relationship exists between @entity64 and @entity4616 , this is more likely in PACI and POCI at a younger age. Our results are consistent with recent findings that underline @entity4616 alone must not be considered a significant independent predictor for @entity64 ; so the presence of @entity4616 alone doesn't permit rushed causal correlations or 'therapeutic @entity146 '.    2015 S. Karger AG, Basel.

title: Prevalence of Patent Foramen Ovale in XXXX in Italy: Results of SISIFO Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['ischaemic stroke', 'stroke']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity4616 :: ('MESH:D054092', 'Disease') :: ['patent foramen ovale', 'PFO']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Ischaemic Stroke']


abstract: INTRODUCTION: @entity281 are commonly encountered a problem and constitute more than 50% of cases in dermatology outpatient departments. Diagnosis of these infections requires the proper use of laboratory methods. OBJECTIVES: This study was conducted to know the etiology of @entity4013 in @entity1 attending Tertiary Care Level Hospital in South India and to compare the efficacy of Sabouraud's dextrose agar (SDA) with @entity1880 and dermatophyte test medium (DTM) in isolating and identifying dermatophytes. MATERIALS AND METHODS: A total of 110 samples which included 101 skin samples and 9 hair samples from clinically suspected @entity4013 were collected. Direct microscopy by @entity3071 and culture on SDA with @entity1880 and DTM were done. RESULTS: Of 110 samples collected, 58.18% were @entity3071 positive for fungal filaments and 56.36% were culture positive for dermatophytes. More number of cases were observed between age groups of 21-40 years. Males were more affected compared to females. @entity4013 was the common clinical presentation observed (40%). @entity12734 (58.06%) was the predominant isolate recovered in all clinical presentations but @entity12734 violaceum was the most common isolate in @entity3100 . All culture positives were grown on both SDA with @entity1880 and DTM. Appearance of growth was earlier on DTM that is, within 10 days compared to SDA with @entity1880 where growth started appearing only after 10 days. This is statistically significant P < 0.0001 (  (2) = 71.6). Species level identification on primary isolation was possible when grown on SDA with @entity1880 and it was not possible with the growth on DTM on primary isolation. CONCLUSION: DTM is a good screening medium in laboratory diagnosis of @entity4013 when compared to SDA with @entity1880 . But DTM is inferior to SDA with @entity1880 in identification of dermatophyte species.

title: Clinicomycological Study of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4013 :: ('MESH:D014005', 'Disease') :: ['dermatophytosis', 'Tinea corporis']

entities_list: @entity1880 :: ('MESH:D003513', 'Chemical') :: ['actidione']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['Dermatophytic infections']

entities_list: @entity3100 :: ('MESH:D014006', 'Disease') :: ['tinea capitis']

entities_list: @entity12734 :: ('5551', 'Species') :: ['Trichophyton rubrum', 'Trichophyton']

answer: @entity4013 :: (MESH:D014005,Disease) :: ['Dermatophytosis in South India']


abstract: BACKGROUND: @entity3043 is a relatively common @entity1503 , the etiological factors of which vary widely in different geographic location. Determining the specific etiology is of immense importance for appropriate management. AIMS AND OBJECTIVES: The present study was undertaken to delineate etiological factors leading to @entity3043 in a Tertiary Care Hospital of West Bengal from Eastern Region of India. MATERIALS AND METHODS: A prospective study was conducted for a period of 2 years in which 248 @entity1 were included. After obtaining a relevant clinical history, physical examination was done followed by complete blood count including peripheral blood smears examination, relevant biochemical, and radiological investigations. Afterward, bone marrow aspiration and biopsy were performed and microscopically examined. RESULTS: Among 248 @entity1 studied, 156 (62.9%) were males and 92 (37.09%) were females. The mean age of the @entity1 was 33 years. @entity2150 was the most common cause of @entity3043 that was observed in 83 cases (33.47%) followed by @entity417 in 52 cases (20.97%), @entity232 in 34 @entity1 (13.71%), @entity6118 also in 34 @entity1 (13.71%), and @entity378 and other connective tissue disorders in 18 cases (7.26%). The occurrence of @entity2150 was statistically significant in pediatric ( <=15 years) age group. CONCLUSION: @entity2150 was found to be the most common cause of @entity3043 in this study, which is in contrast to studies conducted from other regions of India. Delineation of etiologies of @entity3043 in various regions can help in defining diagnostic and therapeutic strategies, which is expected to contribute toward the better management of such @entity1 .

title: Etiology of XXXX : An Observation from a Referral Medical Institution of Eastern Region of India.

entities_list: @entity417 :: ('MESH:D000740', 'Disease') :: ['megaloblastic anemia']

entities_list: @entity2150 :: ('MESH:D000741', 'Disease') :: ['Aplastic anemia', 'aplastic anemia']

entities_list: @entity232 :: ('MESH:D007896', 'Disease') :: ['leishmaniasis']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['hematological condition']

entities_list: @entity6118 :: ('MESH:D006971', 'Disease') :: ['hypersplenism']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

entities_list: @entity3043 :: ('MESH:D010198', 'Disease') :: ['Pancytopenia', 'pancytopenia']

answer: @entity3043 :: (MESH:D010198,Disease) :: ['Pancytopenia']


abstract: UNASSIGNED: Obesity which developes due to multifactorial reasons, was associated recently with @entity1 @entity9504 ( @entity9504 ). The aim of this study was to investigate the prevalence of @entity9504 antibodies in @entity28 adults and also to investigate the DNA of @entity9504 in their adipose tissue. In this cross-sectional and case-control based study, 49 @entity28 adults, with BMI >= 30  kg/m(2), and 49 non- @entity28 adults, with BMI  <=25  kg/m(2), applied for esthetic purposes and were included in this study as @entity1 and control groups, respectively. Adipose tissue samples, obtained by the lipoaspiration method, were studied by single-step PCR and nested-PCR methods. Simultaneously, the presence of @entity9504 antibodies and serum leptin and adiponectin levels were assessed by serum neutralization assay (SNA) and ELISA, respectively. Serum samples which didn't cause a cytopathic effect at >= 1:8 were accepted as positive. @entity9504 antibody was detected in 6 (12.2%) of 49 @entity1 by SNA and was statistically significant (p  <  0.05). @entity9504 DNA was not detected in any of the adipose tissue samples of the @entity1 or control groups. Mean BMI and leptin levels were higher in the @entity9504 -positive group, while adiponectin levels were found to be lower in the @entity9504 -positive group. Although no statistically significant difference was found in @entity165 and @entity412 levels between the two groups (p  >  0.05), lower mean serum @entity165 and @entity412 levels were found in the @entity9504 -positive @entity1 . In conclusion, we couldn't detect @entity9504 DNA in adipose tissue; however, we detected significantly higher @entity9504 antibody levels in the @entity28 group compared to the non- @entity28 group, according to the both univariant and multivariant analyses, suggesting that @entity9504 may play a role in @entity28 . There is a need for new and extended serial, particularly cohort and @entity1 -based, studies in order to have a clear understanding of the @entity9504 relationship.

title: The role of adenovirus 36 as a risk factor in XXXX : The first clinical study made in the fatty tissues of adults in Turkey.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: BACKGROUND: The deaths of American hip-hop and @entity541 recording artists often receive considerable media attention. However, these artists' deaths have not been examined as a distinct group like the deaths of rock, classical, jazz, and pop music artists. This is a seminal epidemiological analysis on the deaths of an understudied group, American hip-hop and @entity541 music recording artists. METHODS: Media reports were analyzed of the deaths of American hip-hop and @entity541 music recording artists that occurred from January 1, 1987 to December 31, 2014. The decedents' age, sex, race, cause of @entity204 , stage names, and city and state of @entity204 were recorded for analysis. RESULTS: The most commonly reported cause of @entity204 was homicide. The 280 deaths were categorized as homicide (55%), @entity130 (13%), cardiovascular (7%), undetermined/undisclosed (7%), @entity5 (6%), other (5%), suicide (4%), and @entity166 (3%). The mean reported age at @entity204 was 30 yrs (range 15-75) and the median was 29 yrs; 97% were male and 92% were black. All but one of the homicides were committed with firearms. CONCLUSIONS: Homicide was the most commonly reported cause of @entity204 . Public health focus and guidance for @entity541 recording artists should mirror that for African-American @entity1 and adolescent males ages 15-54 yrs, for whom the leading causes of @entity204 are homicide, @entity130 , and @entity299 . Given the preponderance of homicide deaths in this analysis, premature mortality reduction efforts should focus on violence prevention and conflict mitigation.

title: Mortality in American Hip-Hop and XXXX Recording Artists, 1987-2014.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['unintentional injury']

answer: @entity541 :: (4043,Gene) :: ['Rap']


abstract: The dietary inflammatory index (DII) is a new tool to assess the inflammatory potential of the diet. In the present study, we aimed to determine the association between the DII and BMI, waist circumference and waist:height ratio (WHtR). We conducted a cross-sectional study of 7236 @entity1 recruited into the PREvenci  n con DIeta MEDiterr  nea trial. Information from a validated 137-item FFQ was used to calculate energy, food and nutrient intakes. A fourteen-item dietary screener was used to assess adherence to the Mediterranean diet (MeDiet). Sex-specific multivariable linear regression models were fitted to estimate differences (and 95 % CI) in BMI, waist circumference and WHtR across the quintiles of the DII. All nutrient intakes, healthy foods and adherence to the MeDiet were higher in the quintile with the lowest DII score (more anti-inflammatory values) except for intakes of animal protein, saturated fat and monounsaturated fat. Although an inverse association between the DII and total energy was apparent, the DII was associated with higher average BMI, waist circumference and WHtR after adjusting for known risk factors. The adjusted difference in the WHtR for @entity1 and @entity1 between the highest and lowest quintiles of the DII was 1  60 % (95 % CI 0  87, 2  33) and 1  04 % (95 % CI 0  35, 1  74), respectively. Pro-inflammatory scores remained associated with @entity28 after controlling for the effect that adherence to a MeDiet had on @entity32 . In conclusion, the present study shows a direct association between the DII and indices of @entity28 , and supports the hypothesis that diet may have a role in the development of @entity28 through inflammatory modulation mechanisms.

title: Dietary inflammatory index and anthropometric measures of XXXX in a population sample at high cardiovascular risk from the PREDIMED (PREvenci  n con DIeta MEDiterr  nea) trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: OBJECTIVE: The precise etiology of @entity29 ( @entity29 ) is still unknown although dysregulation of apoptosis likely plays an important role in this pathogenesis. However, the significance of @entity33 -cell apoptosis in @entity31 ( @entity31 ) is unclear. In the present work we investigated the role of @entity2205 ( @entity2205 ), which is implicated in various @entity1 disorders. @entity1 AND METHODS: Results from a total of 393 @entity31 @entity1 and 1292 healthy individuals were analyzed in this study. We determined the three single nucleotide polymorphisms of @entity2205 in 3' untranslated regions (UTR), and examined the plasma soluble @entity2205 (sTRAIL) levels by enzyme-linked immunosorbent assay. RESULTS: We found that the mutant genotypes of @entity2205 ( @entity71692 / @entity71693 / @entity71157 and @entity71692 and @entity71693 ) were much lower in @entity31 @entity1 compared to the controls. Furthermore, mutant allele and genotype of @entity2205 @entity71157 were more prevalent in severe @entity31 @entity1 than in other @entity1 (p < 0.001; p = 0.005, respectively). The three polymorphic sites in 3'UTR were in a perfect linkage disequilibrium in our study. In contrast to controls, the GAT haplotype was increased (p < 0.001), while the AAT haplotype was decreased in @entity31 @entity1 (p < 0.001). Besides, the plasma levels of sTRAIL were significantly higher in @entity31 @entity1 than in controls (p < 0.001). CONCLUSIONS: Our findings suggested that increased occurrence of the genetic mutations of @entity2205 in 3'UTR and possibly decreased plasma levels of sTRAIL might lead to a lower risk of @entity31 attack in Chinese @entity1 .

title: Association of XXXX with TNF-related apoptosis inducing ligand ( @entity2205 ) gene polymorphisms and plasma soluble @entity2205 levels in Chinese Han population.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'PATIENTS']

entities_list: @entity2205 :: ('8743', 'Gene') :: ['TNF-related apoptosis-inducing ligand', 'TRAIL']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal T']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['IBDs', 'inflammatory bowel diseases']

answer: @entity31 :: (MESH:D003093,Disease) :: ['ulcerative colitis']


abstract: OBJECTIVE: The precise etiology of @entity29 ( @entity29 ) is still unknown although dysregulation of apoptosis likely plays an important role in this pathogenesis. However, the significance of @entity33 -cell apoptosis in @entity31 ( @entity31 ) is unclear. In the present work we investigated the role of @entity2205 ( @entity2205 ), which is implicated in various @entity1 disorders. @entity1 AND METHODS: Results from a total of 393 @entity31 @entity1 and 1292 healthy individuals were analyzed in this study. We determined the three single nucleotide polymorphisms of @entity2205 in 3' untranslated regions (UTR), and examined the plasma soluble @entity2205 (sTRAIL) levels by enzyme-linked immunosorbent assay. RESULTS: We found that the mutant genotypes of @entity2205 ( @entity71692 / @entity71693 / @entity71157 and @entity71692 and @entity71693 ) were much lower in @entity31 @entity1 compared to the controls. Furthermore, mutant allele and genotype of @entity2205 @entity71157 were more prevalent in severe @entity31 @entity1 than in other @entity1 (p < 0.001; p = 0.005, respectively). The three polymorphic sites in 3'UTR were in a perfect linkage disequilibrium in our study. In contrast to controls, the GAT haplotype was increased (p < 0.001), while the AAT haplotype was decreased in @entity31 @entity1 (p < 0.001). Besides, the plasma levels of sTRAIL were significantly higher in @entity31 @entity1 than in controls (p < 0.001). CONCLUSIONS: Our findings suggested that increased occurrence of the genetic mutations of @entity2205 in 3'UTR and possibly decreased plasma levels of sTRAIL might lead to a lower risk of @entity31 attack in Chinese @entity1 .

title: Association of @entity31 with TNF-related apoptosis inducing ligand ( XXXX ) gene polymorphisms and plasma soluble @entity2205 levels in Chinese Han population.

answer: @entity2205 :: (8743,Gene) :: ['TRAIL']


abstract: OBJECTIVE: The precise etiology of @entity29 ( @entity29 ) is still unknown although dysregulation of apoptosis likely plays an important role in this pathogenesis. However, the significance of @entity33 -cell apoptosis in @entity31 ( @entity31 ) is unclear. In the present work we investigated the role of @entity2205 ( @entity2205 ), which is implicated in various @entity1 disorders. @entity1 AND METHODS: Results from a total of 393 @entity31 @entity1 and 1292 healthy individuals were analyzed in this study. We determined the three single nucleotide polymorphisms of @entity2205 in 3' untranslated regions (UTR), and examined the plasma soluble @entity2205 (sTRAIL) levels by enzyme-linked immunosorbent assay. RESULTS: We found that the mutant genotypes of @entity2205 ( @entity71692 / @entity71693 / @entity71157 and @entity71692 and @entity71693 ) were much lower in @entity31 @entity1 compared to the controls. Furthermore, mutant allele and genotype of @entity2205 @entity71157 were more prevalent in severe @entity31 @entity1 than in other @entity1 (p < 0.001; p = 0.005, respectively). The three polymorphic sites in 3'UTR were in a perfect linkage disequilibrium in our study. In contrast to controls, the GAT haplotype was increased (p < 0.001), while the AAT haplotype was decreased in @entity31 @entity1 (p < 0.001). Besides, the plasma levels of sTRAIL were significantly higher in @entity31 @entity1 than in controls (p < 0.001). CONCLUSIONS: Our findings suggested that increased occurrence of the genetic mutations of @entity2205 in 3'UTR and possibly decreased plasma levels of sTRAIL might lead to a lower risk of @entity31 attack in Chinese @entity1 .

title: Association of @entity31 with TNF-related apoptosis inducing ligand ( @entity2205 ) gene polymorphisms and plasma soluble XXXX levels in Chinese Han population.

answer: @entity2205 :: (8743,Gene) :: ['TRAIL']


abstract: OBJECTIVE: This study was conducted in order to investigate the effects of @entity5536 -induced @entity740 ( @entity740 ) on renal blood flow and biochemical changes in @entity35 , and to assess the effect of treatment with gum acacia (GA) thereon. MATERIALS AND METHODS: @entity740 was induced by feeding @entity35 with @entity5536 (0.25% w/w, five weeks). Concomitantly, some of these @entity35 were also given gum acacia (GA) (15% w/v in the drinking water).   Before animals were sacrificed, changes in renal blood flow (RBF) were monitored in anaesthetized @entity35 preparations. Several biochemical and histological renal function tests were also conducted. RESULTS: @entity5536 -induced @entity740 significantly impaired the vasopressor actions of @entity934 , @entity1854 and @entity2647 and concomitant treatment with GA abated these responses. Additionally,   plasma concentrations of @entity1133 , @entity1011 , @entity414 , @entity6634 , @entity3542 and @entity1507 and urinary excretion of protein were all significantly increased by @entity5536 . GA significantly mitigated the severity of @entity5536 - induced changes. CONCLUSIONS: @entity5536 -induced @entity740 in @entity35 significantly @entity8 responses to @entity934 , @entity1854 and @entity2647 and this was mitigated by treatment with GA. This provides another experimental evidence for the usefulness of GA in the amelioration of @entity740 .

title: Influence of treatment with gum acacia on renal vascular responses in a @entity35 model of XXXX .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['impaired renal vascular']

entities_list: @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite']

entities_list: @entity1854 :: ('MESH:D009599', 'Chemical') :: ['sodium nitroprusside']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity5536 :: ('MESH:D000225', 'Chemical') :: ['Adenine', 'adenine']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

entities_list: @entity6634 :: ('MESH:D007200', 'Chemical') :: ['indoxyl sulfate']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity740 :: (MESH:D051436,Disease) :: ['chronic kidney disease']


abstract: OBJECTIVE: This study was conducted in order to investigate the effects of @entity5536 -induced @entity740 ( @entity740 ) on renal blood flow and biochemical changes in @entity35 , and to assess the effect of treatment with gum acacia (GA) thereon. MATERIALS AND METHODS: @entity740 was induced by feeding @entity35 with @entity5536 (0.25% w/w, five weeks). Concomitantly, some of these @entity35 were also given gum acacia (GA) (15% w/v in the drinking water).   Before animals were sacrificed, changes in renal blood flow (RBF) were monitored in anaesthetized @entity35 preparations. Several biochemical and histological renal function tests were also conducted. RESULTS: @entity5536 -induced @entity740 significantly impaired the vasopressor actions of @entity934 , @entity1854 and @entity2647 and concomitant treatment with GA abated these responses. Additionally,   plasma concentrations of @entity1133 , @entity1011 , @entity414 , @entity6634 , @entity3542 and @entity1507 and urinary excretion of protein were all significantly increased by @entity5536 . GA significantly mitigated the severity of @entity5536 - induced changes. CONCLUSIONS: @entity5536 -induced @entity740 in @entity35 significantly @entity8 responses to @entity934 , @entity1854 and @entity2647 and this was mitigated by treatment with GA. This provides another experimental evidence for the usefulness of GA in the amelioration of @entity740 .

title: Influence of treatment with gum acacia on renal vascular responses in a XXXX model of @entity740 .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND CONTEXT: @entity3083 occurring after percutaneous @entity3574 has rarely been described. To date, only two such cases have been documented in the literature. @entity3574 may reactivate a quiescent tuberculous lesion and promote the infective process in elderly @entity1 with or without immunosuppression, thereby resulting in poor outcomes. PURPOSE: The purposes of this study were to present two cases in which spinal @entity378 occurred after vertebroplasty or kyphoplasty, to highlight the clinical features and need for early diagnosis of this pathology, and to postulate probable reasons for this association. STUDY DESIGN: This study is based on a clinical case series and literature review. METHODS: In this report, we review the clinical histories of two old @entity1 undergoing @entity3574 with subsequent spinal @entity378 . RESULTS: The first @entity1 responded favorably to conservative treatment with multidrug antitubercular therapy and spinal braces. The second @entity1 underwent surgical debridement through a posterior approach alone, without instrumentation, combined with adjuvant chemotherapy. By 1 year after treatment, both @entity1 had experienced almost complete recovery and continued to be seen for follow-up visits. CONCLUSIONS: Suspicion should be high, and magnetic resonance imaging is warranted in cases with deteriorating clinical symptoms and signs of @entity697 after @entity3574 . We propose obtaining exhaustive microbiologic and histologic evidence via needle biopsy or open surgery in a timely fashion to establish an accurate diagnosis because @entity1511 occurring in such a situation may progress rapidly.

title: @entity3083 of the lumbar spine after percutaneous XXXX (vertebroplasty or kyphoplasty).

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute infection']

entities_list: @entity3574 :: ('OMIM:277300', 'Disease') :: ['vertebral augmentation', 'Vertebral augmentation']

entities_list: @entity3083 :: ('MESH:D014399', 'Disease') :: ['Spinal tuberculosis']

entities_list: @entity1511 :: ('MESH:D013166', 'Disease') :: ['tubercular spondylitis']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

answer: @entity3574 :: (OMIM:277300,Disease) :: ['vertebral augmentation']


abstract: BACKGROUND CONTEXT: @entity3083 occurring after percutaneous @entity3574 has rarely been described. To date, only two such cases have been documented in the literature. @entity3574 may reactivate a quiescent tuberculous lesion and promote the infective process in elderly @entity1 with or without immunosuppression, thereby resulting in poor outcomes. PURPOSE: The purposes of this study were to present two cases in which spinal @entity378 occurred after vertebroplasty or kyphoplasty, to highlight the clinical features and need for early diagnosis of this pathology, and to postulate probable reasons for this association. STUDY DESIGN: This study is based on a clinical case series and literature review. METHODS: In this report, we review the clinical histories of two old @entity1 undergoing @entity3574 with subsequent spinal @entity378 . RESULTS: The first @entity1 responded favorably to conservative treatment with multidrug antitubercular therapy and spinal braces. The second @entity1 underwent surgical debridement through a posterior approach alone, without instrumentation, combined with adjuvant chemotherapy. By 1 year after treatment, both @entity1 had experienced almost complete recovery and continued to be seen for follow-up visits. CONCLUSIONS: Suspicion should be high, and magnetic resonance imaging is warranted in cases with deteriorating clinical symptoms and signs of @entity697 after @entity3574 . We propose obtaining exhaustive microbiologic and histologic evidence via needle biopsy or open surgery in a timely fashion to establish an accurate diagnosis because @entity1511 occurring in such a situation may progress rapidly.

title: XXXX of the lumbar spine after percutaneous @entity3574 (vertebroplasty or kyphoplasty).

answer: @entity3083 :: (MESH:D014399,Disease) :: ['Spinal tuberculosis']


abstract: INTRODUCTION: @entity286 use increases the risk of mortality, @entity5 and @entity65 in transplanted @entity1 . Transplanted @entity1 are encouraged to quit @entity286 use before and after renal transplantation. This study was carried out to evaluate the prevalence of @entity286 consumption in transplanted @entity1 in one French region. This survey was also conducted to identify factors associated with failure in smoking cessation. MATERIALS AND METHOD: A questionnaire was sent by mail to transplanted @entity1 followed in our center between the 1/01/95 and the 31/12/10. A second mail was sent to increase the response rate. RESULTS: During the study period, 544  questionnaires were sent to kidney transplant recipients. Among these 544  @entity1 , there were 362  responders. Of these 362  @entity1 , 121  @entity1 (33.4%) were past smokers, and 21 (5.8%) were active smokers. Among the smokers, 20% were exposed to second-hand smoke, 48% had criteria for @entity286 moderate to high dependency, and 13.4% were addicted to @entity285 . In the multivariate analysis, exposure to second-hand smoke and living alone at home were associated with failure in smoking cessation. CONCLUSION: This study shows that the prevalence of @entity286 use is not high in transplanted @entity1 . Only 6% of our @entity1 report @entity286 use at the study time. Environmental factors are associated with failure in @entity286 cessation. Living alone and exposure to second-hand smoke are associated with smoking. Therefore, in transplantation centers, programs devoted to @entity286 cessation should be implemented and should take care of @entity1 ' lifestyle.

title: [PRETAGREF study: Prevalence of XXXX use and factors associated with smoking cessation in kidney transplant recipients].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity286 :: ('4097', 'Species') :: ['tobacco', 'Tobacco']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity286 :: (4097,Species) :: ['tobacco']


abstract: UNASSIGNED: Autophagy is an intracellular process leading to vacuolar or lysosomal degradation of cytoplasmic components in eukaryotes. Establishment of proper methods to monitor autophagy was a key step to uncover its role in organisms such as @entity375 , mammals and @entity958 , in which chloroplastic proteins were found to be recycled by autophagy. Chloroplast recycling has been predicted to function in nutrient remobilization for growing organs or grain filling in cereal crops. Here, to develop our understanding of autophagy in cereals, we established monitoring methods for chloroplast autophagy in @entity579 ( @entity579 ). We generated transgenic @entity579 expressing fluorescent protein (FP)-OsATG8 fusions as autophagy markers. FP-ATG8 signals were delivered into the vacuolar lumen in living cells of roots and leaves mainly as vesicles corresponding autophagic bodies. This phenomenon was not observed upon the addition of @entity2307 , an inhibitor of autophagy, or in an AUTOPHAGY7 knockout mutant. Markers for the chloroplast stroma, stromal FP and FP-labeled Rubisco, were delivered via a type of autophagic body called the @entity1053 ( @entity1053 ) in the same manner. @entity1053 production in excised leaves was suppressed by supply of external Suc or light. The release of free FP due to autophagy-dependent breakdown of FP-labeled Rubisco was induced during accelerated senescence in individually-darkened leaves. In roots, non-green plastids underwent both @entity1053 -mediated and entire-organelle types of autophagy. Therefore, our newly developed methods to monitor autophagy directly demonstrated autophagic degradation of leaf chloroplasts and root plastids in @entity579 plants and its induction during energy limitation.

title: Establishment of monitoring methods for autophagy in XXXX reveals autophagic recycling of chloroplasts and root plastids during energy limitation.

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis thaliana']

entities_list: @entity2307 :: ('MESH:C009687', 'Chemical') :: ['wortmannin']

entities_list: @entity1053 :: ('MESH:D001835', 'Disease') :: ['Rubisco-containing body', 'RCB']

entities_list: @entity579 :: ('4530', 'Species') :: ['Oryza sativa', 'rice']

answer: @entity579 :: (4530,Species) :: ['rice']


abstract: This is a report of the third in a series of experiments carried out to identify and to determine the reliability of atrial pacemakers below the sinoatrial (SA) node. This information could be useful to the surgeon in planning both corrective atrial operations and direct operations for @entity943 . In this study, done in @entity235 , the @entity955 containing the atrioventricular (AV) node was completely separated from the remaining atria. Seven @entity235 survived for 35 to 116 days. Serial electrocardiograms (ECGs) after operation showed that four of the seven @entity235 developed a regular junctional rhythm with a rate of 85 beats/min, whereas three of seven developed an irregular junctional rhythm with pauses and bigeminy. In a control study, in which the AV node was disconnected from the His bundle, a slow regular junctional rhythm was produced in all three of the @entity235 . Thus, in the series of three experiments, this being the report of the last one, a hierarchy of pacemakers below the SA node was identified. The first one, a pacemaker in the low right atrium in the region of the coronary sinus, was the most reliable and was associated with a normal ECG. A second, in the @entity955 , did not develop dominance in all @entity235 . However, the junctional pacemaker in the His bundle always became dominant after the AV node was disconnected from the His bundle and was associated with a regular but slow rhythm.

title: Surgical isolation of the XXXX from the atria. Identification of an atrial septal pacemaker.

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['atrial arrhythmias']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial septum']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial septum']


abstract: The clinical, laboratory and pathologic findings were studied in 62 consecutively autopsied @entity1 with @entity1582 between 1954 and 1975. All @entity1 were 40 years of age or older. Bone @entity158 was the initial symptom in 2/3 of @entity1 . @entity417 (81%), @entity882 (29%), @entity2629 (41%), @entity2741 (46%) and @entity5052 (52%), were common laboratory findings at diagnosis. Ninety-seven percent had a monoclonal protein in serum or urine. Extensive plasma cell replacement of marrow was invariably seen at autopsy although in 15% of @entity1 no abnormality was found on skeletal survey. Extraskeletal spread (67%) was due to direct extension to paraosseous tissue resulting from cortical destruction and to distant organ involvement mainly of splenic red pulp and hepatic sinusoids. The @entity1 were susceptible to @entity2348 , mainly gram-negative, of the lung (56%), urinary tract (35%), and blood (24%). @entity364 was less frequent and usually consisted of superficial candidal overgrowth of gastrointestinal tract @entity1066 (18%). @entity2783 (10%) was perivascular and associated with light chain @entity644 . @entity177 as a cause of @entity204 (21%) was secondary only to @entity281 (52%). Severity of histologic findings in the kidney at autopsy had little correlation to initial BUN concentration. The median survival was 11.5 months with alkylating agent therapy (responders, 29 months; non-responders, 6 months), and 6 months with @entity4774 . Initial @entity2629 (greater than 80 mg/dl) and @entity2741 (greater than 12 mg/dl) were important prognostic indicators (median survival, less than 1 month and 3 months, respectively). A good response to alkylating agent therapy, initial BUN less than 40 mg/dl and serum @entity460 less than 12 mg/dl were favorable to prognostic indicators.

title: XXXX : a clinicopathologic study of 62 consecutively autopsied cases.

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity2741 :: ('MESH:D006934', 'Disease') :: ['hypercalcemia']

entities_list: @entity2783 :: ('MESH:D000686', 'Disease') :: ['Amyloidosis']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcerations']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['Fungal infection']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['Renal failure']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity5052 :: ('MESH:D033461', 'Disease') :: ['hyperuricemia']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['Multiple myeloma']


abstract: AIM: Comparing the different possible surgical procedures and the results in urgent/emergency and in elective surgery for obstructing @entity14 . MATERIAL OF STUDY: From 2008 we operated on 238 @entity1 affected by @entity14 , 115 obstructing and 19 perforated. 23 @entity1 had right-sided and 92 left-sided obstructing @entity5 , divided retrospectively in 4 groups. 18 decompressive colostomy; 32 two-stages procedures: 25 Hartmann's operations and 7 total colectomies with terminal ileostomy; 7 one-stage procedures, with defunctioning ileostomy: 4 total colectomies and 3 colonic resections with wash-out; 35 one-stage procedures with primary @entity254 +wash-out or milking. RESULTS: Operative mortality is 7% in urgent/emergency versus 1% in elective surgery and anastomotic leakage affected 6 /58 cases, 5 requiring additional surgery. Overall, about 2/3 of the perioperative @entity204 were related to general complications and 1/3 to anastomotic failure. The local recurrence rate was 7% in elective and 11% in urgent/emergency surgery. DISCUSSION AND CONCLUSIONS: Obstructing @entity14 is associated with a high operative mortality and a worse prognosis, in terms of recurrence and survival. Actually, immediate resection with primary @entity254 represents the goldstandard in selected @entity1 with a low anaesthetic risk, performing either as a typical resection with wash-out, or a subtotal colectomy; a temporary defunctioning colostomy or ileostomy could be proposed for @entity1 with an intermediate risk; in high-risk cases, advanced obstruction, simultaneous @entity694 , metastatic or locally advanced disease, Hartmann's operation should be used, as a safer procedure. Colon stenting can be an useful palliative or bridge-to-surgery option. KEY WORDS: Bowel obstruction, @entity14 , Primary @entity254 .

title: Our experience in the management of obstructing XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['colonic tumour']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic perforation']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'colorectal cancer, 136 complicated tumours', 'colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: BACKGROUND: @entity2416 ( @entity2416 ) is a progressive disease, leading to substantial physical impairment. The distance walked in 6 min (6MWD) is a measure of exercise tolerance and is of prognostic relevance in @entity2416 . While 6MWD is a punctual measurement which may not be representative, self-reported daily life activity may represent the @entity1 ' functional capacity more globally even in less severe affected @entity1 . OBJECTIVES: We evaluated and characterized a simple classification system based on the @entity1 ' self-reported daily activity and analyzed if this would add significantly to the prognostic information of the 6MWD alone in @entity2416 @entity1 . METHODS: Daily life activity was assessed in @entity2416 (n = 156) @entity1 with standardized questions and categorized in activity classes (AC I-IV), comprising the less severe impaired in AC I and II. The 6MWD was also assessed. RESULTS: ACs were related to the lung functional impairment and inversely correlated to the 6MWD. Thirty-two @entity1 were in AC I/II, 98 in @entity63496 and 26 @entity1 in AC IV. Thirty-seven (23.7%) @entity1 died during a median follow-up of 14.9 months, comprising 1 @entity1 in AC I/II. In addition, a 6MWD <470 m predicted mortality. Combining AC I/II and a 6MWD >470 m identified a subgroup of @entity1 with favorable outcome. CONCLUSIONS: AC is a novel scoring system which can easily be obtained and correlates with lung functional and physical impairments as well as mortality. Moreover, AC adds prognostic information to the 6MWD.

title: Self-Report Daily Life Activity as a Prognostic Marker of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2416 :: ('MESH:D054990', 'Disease') :: ['Idiopathic pulmonary fibrosis', 'IPF']

answer: @entity2416 :: (MESH:D054990,Disease) :: ['Idiopathic Pulmonary Fibrosis']


abstract: UNASSIGNED: The leaf surface usually stays flat, maintained by coordinated growth. Growth perturbation can introduce overall surface curvature, which can be negative, giving a saddle-shaped leaf, or positive, giving a cup-like leaf. Little is known about the molecular mechanisms that underlie @entity12318 , primarily because only a few mutants with altered surface curvature have been isolated and studied. Characterization of mutants of the CINCINNATA-like @entity33949 genes in Antirrhinum and @entity958 have revealed that their products help maintain @entity12318 by balancing the pattern of cell proliferation and surface expansion between the margin and the central zone during leaf morphogenesis. On the other hand, deletion of two homologous PEAPOD genes causes cup-shaped leaves in @entity958 due to excess division of dispersed meristemoid cells. Here, we report the isolation and characterization of an @entity958 mutant, tarani (tni), with enlarged, cup-shaped leaves. Morphometric analyses showed that the positive curvature of the tni leaf is linked to excess growth at the centre compared to the margin. By monitoring the dynamic pattern of CYCLIN D3;2 expression, we show that the shape of the primary arrest front is strongly convex in growing tni leaves, leading to excess mitotic expansion synchronized with excess cell proliferation at the centre. Reduction of cell proliferation and of endogenous @entity9635 levels rescued the tni phenotype. Genetic interactions demonstrated that TNI maintains @entity12318 independent of TCPs and PEAPODs.

title: The tarani mutation alters surface curvature in XXXX leaves by perturbing the patterns of surface expansion and cell division.

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis']

entities_list: @entity9635 :: ('MESH:C007842', 'Chemical') :: ['gibberellic acid']

entities_list: @entity12318 :: ('MESH:D005413', 'Disease') :: ['flatness', 'leaf flatness']

answer: @entity958 :: (3702,Species) :: ['Arabidopsis']


abstract: Twenty-seven crosses derived from three random-mating, unselected strains of @entity19 (SWO, J, PGH) with 16 matings/pureline or cross were cohabited continuously and monogamously for 365 d to evaluate long-term reproductive performance of the parents. Data from 3,249 litters born were analyzed to study the effects of parity (number of litters) and type of cross (pureline, two-way, backcross, three-way) on the following traits: 1) continuity of reproduction ( @entity30486 ), 2) litter size at birth (LSB), 3) age at first litter (AFL), 4) fraction alive at birth-the ratio of number born alive to LSB (FAB), 5) birth to birth interval (BBI) and 6) reproductive rate-the ratio of number born alive to birth to birth interval (RRT). Reproductive rate was also studied in a cumulative manner rather than on a per parity basis by regressing cumulative number born alive on cumulative birth to birth interval. Parity effects were important (P less than .01) for all traits measured. Differences among cross-types were highly significant for @entity30486 , LSB and RRT. Three-way crosses were more productive than backcrosses, and both were superior to two-way and pureline matings. Uniformity was greater among three-way crosses for all traits except @entity30486 . Cross-types differed importantly in the pattern of change in performance over parities for @entity30486 , LSB, FAB, RRT and cumulative number of live young (P less than .01). Number of parities were most important for variation in longevity of reproduction ( @entity30486 ) and somewhat for litter size (LSB). Mean and cumulative reproductive rates were influenced more by longevity and litter size than by interval between births.

title: Lifetime parental productivity in twenty-seven crosses of XXXX . I. Birth traits.

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: @entity454 ( @entity454 ) has become a major health problem in Sub Saharan Africa (SSA). There were limited data about causes of @entity454 in the Sudan. METHODS: This is a cross sectional hospital based descriptive study. The subjects of the study are @entity454 adults' @entity1 on regular haemodialysis treatment in 15 haemdoialysis centres in Khartoum State-Sudan. Clinical and epidemiological data were obtained from 1583 @entity1 . The medical files of each @entity1 were reviewed to identify the cause of @entity454 . Concerning the causes of @entity454 , @entity6 was diagnosed based on the past medical history and result of the @entity413 tolerance test, @entity101 was diagnosed based on past history of @entity101 based on blood pressure of more than 140/90  mmHg, @entity631 was diagnosed based on results of previous kidney biopsies and on clinical grounds, @entity8 and obstructive @entity3551 were diagnosed based on abdominal ultrasound and other imaging modalities, sickle cell anaemia was diagnosed based on the result of haemoglobin electrophoresis, @entity1252 was diagnosed based on the clinical criteria in addition to lab results of auto antibodies, and analgesic @entity8 was diagnosed based on past medical history of chronic analgesic drugs usage with no other identifiable risk factors. We included all @entity454 @entity1 on regular haemodialysis treatment. We excluded @entity454 @entity1 less than 18  years old. RESULTS: The results showed that the mean age of @entity454 @entity1 was 49      15.8 (years) and 63.4  % were male and 76.3  % were unemployed. The mean duration of haemodialysis is 4.38      4.24 (years). The most common cause of @entity454 in our @entity1 was @entity101 (34.6  %) followed by chronic @entity631 (17.6  %), @entity6 (12.8  %), obstructive @entity3551 (9.6  %), @entity8 ( @entity8 ) (4.7  %), chronic @entity2885 (4.6  %), analgesic @entity8 (3.5  %). However in (10.7  %) no cause was found. In @entity1 aged less than 40  years old the leading cause of @entity454 was @entity631 (29.3  %) followed by @entity101 (25  %). In @entity1 aged between 40 to 60  years old the leading cause of @entity454 was @entity101 (38.5  %) followed by @entity6 (14  %). In @entity1 aged older than 60  years the leading cause of @entity454 was @entity101 (38.4  %) followed by @entity6 (23.3  %). CONCLUSIONS: @entity454 in Sudan affects the economically productive age group; unemployment rate among @entity454 @entity1 is high. The study showed that @entity101 is a leading cause of @entity454 in Sudan followed by chronic @entity631 . @entity101 and @entity6 are the leading causes of @entity454 among @entity1 over 40  years old.

title: Causes of end stage renal failure among haemodialysis XXXX in Khartoum State/Sudan.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['polycystic kidney disease', 'nephropathy', 'ADPKD', 'autosomal dominant poly cystic kidney disease']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['systemic lupus erythematosus']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['End stage renal failure', 'ESRF']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: To analyze the intraocular pressure reduction, number of anti- @entity726 medications needed, and post-operative complications of trans-scleral diode laser cyclophotocoagulation (DCPC) in @entity1 with high-risk penetrating keratoplasty (PKP) and secondary refractory @entity726 . Prospective interventional, longitudinal, non-comparative series of cases, including 16 eyes of 15 @entity1 's post-PKP on maximal anti- @entity726 medical therapy with intraocular pressures above 22  mmHg. All @entity1 received 18 shots, 360   peri-limbal (avoiding the long posterior ciliary nerves and arteries at 3 and 9 o'clock positions) of trans-scleral DCPC (2000  mW, time: 2.0  s/shot). There was a 55.5  % reduction (total of 14.0  mmHg) of the mean pre-operative IOP (31.5  mmHg) after the first diode laser application (p  =  0.0020). Re-treatment was required in 31.2  % of eyes over a mean period of 10.7  months. In these five eyes, the mean pre-operative IOP was 40.4  mmHg, which decreased to 15.0  mmHg post-therapy, and a mean IOP reduction of 25.4  mmHg (p  =  0.0218). There was a 51.0  % reduction in the mean number of medications used after the first, and a 57.1  % reduction after a second laser application. The incidence of failure (IOP  >=   22  mmHg or need of additional medical therapy) from initial intervention to loss of follow-up was 1.3  % per @entity1 -month. DCPC effectively reduces the intraocular pressure and the number of anti- @entity726 medications with few complications in @entity1 after high-risk PKP and @entity726 . Only, one-third of the eyes needed a second intervention to control the intraocular pressure. Post-DCPC complications were limited to phthisis bulbi and @entity409 , one eye each. Please check and confirm the author names and initials are correct. Also, kindly confirm the details in the metadata are correct.

title: Trans-scleral diode laser cyclophotocoagulation for refractory XXXX after high-risk penetrating keratoplasty.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'person']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma', 'secondary glaucoma']

answer: @entity726 :: (MESH:D005901,Disease) :: ['glaucoma']


abstract: UNASSIGNED: The quadriceps femoris (QF) muscle group plays an essential role in @entity1 movement, such as standing, walking and running. The ability to maintain a steady force during physical activity of the @entity1 lower limb is important for mobility, postural control and balance. Although prolonged mechanical vibration of the muscle-tendon unit can moderate the efficacy of synaptic input from Ia afferent onto the a-motor neuron pathway, the effect of prolonged tendon vibration on fluctuations of knee extensor force has received little attention. The purpose of the present study was to examine the effects of @entity1162 on the force steadiness of the QF muscle. Nine healthy @entity1 performed a submaximal force-matching task involving isometric knee extension before and after patellar tendon vibration or quiet seated rest (n  =  7, control condition) for 30  min. The target force was 2.5, 10 and 30  % of maximal @entity2472 (MVC). Surface electromyography (EMG) of the four QF synergists was recorded and normalized to EMG amplitude during the MVC. The knee extension force and the EMG amplitude of vastus medialis during the MVC were significantly reduced after the vibration, but did not significantly decrease in the control condition. Fluctuations of force and normalized EMG of individual QF muscles at each submaximal force level did not significantly change after the vibration. We conclude that @entity1162 does not influence the force steadiness of the QF muscle during an isometric force-matching task.

title: Effects of XXXX in quadriceps femoris during force-matching task.

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['prolonged patellar tendon vibration']

entities_list: @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary contraction']

answer: @entity1162 :: (MESH:D008133,Disease) :: ['prolonged patellar tendon vibration on force steadiness']


abstract: OBJECTIVES: To evaluate the health outcomes and economics associated with the current guidance relating to the prevention of falls in the elderly through @entity560 supplementation. SETTING: UK. @entity1 : UK population aged 60   years and above. INTERVENTIONS: A Markov health state transition model simulated @entity1 transitions between key fall-related outcomes using a 5-year horizon and annual cycles to assess the costs and benefits of empirical treatment with @entity31864 800   iu daily. PRIMARY AND SECONDARY OUTCOME MEASURES: Costs and health outcomes attributable to fall prevention following @entity560 supplementation. RESULTS: Our model shows that treating the UK population aged 60   years and above with 800   iu @entity31864 would, over a 5-year period: (1) prevent in excess of 430   000 minor falls; (2) avoid 190   000 major falls; (3) prevent 1579 acute @entity204 ; (4) avoid 84   000 @entity1 -years of long-term care and (5) prevent 8300 @entity204 associated with increased mortality in long-term care. The greatest gains are seen among those 75   years and older. Based on reduction in falls alone, the intervention in all adults aged 65+ is cost-saving and leads to increased quality adjusted life years. Treating all adults aged 60+ incurs an intervention cost of   2.70bn over 5   years, yet produces a -  3.12bn reduction in fall-related costs; a net saving of   420M. Increasing the lower bound age limit by 5-year increments increases budget impact to -  1.17bn, -  1.75bn, and -  2.06bn for adults 65+, 70+ and 75+, respectively. CONCLUSIONS: This study shows that treatment of the elderly UK population with @entity31864 800   iu daily would be associated with reductions in mortality and substantial cost-savings through fall prevention.

title: Cost-effectiveness and budget impact of Empirical XXXX therapy on unintentional falls in older adults in the UK.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'person', 'PARTICIPANTS']

entities_list: @entity31864 :: ('CHEBI:28940', 'Chemical') :: ['colecalciferol']

entities_list: @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D']

answer: @entity560 :: (MESH:D014807,Chemical) :: ['vitamin D']