abstract: @entity526 serotype O157:H7 has been epidemiologically linked to outbreaks of @entity548 associated with fast-food restaurants and nursing homes. Sporadic cases now exceed those associated with outbreaks. The incidence of the organism in @entity1 with common @entity294 syndromes and in asymptomatic @entity1 is unknown. Routine serotyping of @entity526 isolates is impractical for most clinical microbiology laboratories. We developed a screening plate by utilizing @entity5121 fermentation as a biochemical marker to identify organisms for serotyping. A total of 2,552 stool samples were screened. In 106 (4.1%), @entity5121 -negative @entity526 were identified. Of these, two were serotype O157:H7, and both produced a Vero cell toxin. One @entity1 had @entity548 and the other a mild, febrile, self-limited @entity294 with no other bacterial pathogen identified. This plate provides an easy, effective method of screening for @entity5121 -negative @entity526 , a process facilitating the selection of organisms for serotyping and one that may help clarify this organism's role in @entity1 disease.

title: Results of a screening method used in a 12-month stool survey for XXXX O157:H7.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient', 'persons']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic colitis']

entities_list: @entity5121 :: ('MESH:D013012', 'Chemical') :: ['sorbitol']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity526 :: (562,Species) :: ['Escherichia coli']


abstract: Cytologic diagnosis of @entity20372 can be very challenging. We report fine needle aspiration cytology (FNAC) findings of a benign @entity20372 . The cytologic features are characterized by hypercellularity and the presence of numerous atypical dispersed cells with epithelioid morphology and intact cytoplasm. The nuclei showed stippled chromatin, irregular nuclear membrane, and prominent eosinophilic nucleoli. No @entity39 or mitoses were seen. The presence of naked nuclei, and extensive intranuclear cytoplasmic inclusions were identified and raised the possibility of @entity20372 . Immunohistochemically, the atypical cells showed strong positivity for myosin heavy chain, @entity4206 , and @entity4205 , while the epithelial cells reacted with @entity172 receptors. This immunophenotypic pattern supports the myoepithelial origin of the atypical cell proliferation and favors the diagnosis of benign @entity20372 . However, biopsy was recommended to exclude @entity5 . Histologically, the @entity5 showed prominent myoepithelial cells with significant atypia, intranuclear cytoplasmic inclusions, and dense cytoplasm. No evidence of @entity5 was identified. In conclusion, we report a case of @entity20372 with a significant cytological atypia that may result in confusion with @entity0 . The presence of intranuclear cytoplasmic inclusions, naked nuclei, and expression of myoepithelial markers should provide clues to the right diagnosis and benign nature of this lesion. Cytopathologists should be familiarized with this entity to avoid a misdiagnosis of @entity189 .

title: Fine-needle aspiration biopsy of XXXX : a potential false positive pitfall and presence of intranuclear cytoplasmic inclusions.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['malignant breast tumors']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancy']

entities_list: @entity20372 :: ('MESH:D055331', 'Disease') :: ['adenomyoepithelioma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast adenomyoepithelioma']


abstract: Thirty-six cases of late onset @entity3225 in @entity1 with filtering @entity4530 are presented. Onset of @entity3225 ranged from 4 months to 60 years after @entity4530 formation. Possible contributing factors could be identified only in a minority of @entity1 . Aqueous, vitreous or both were cultured in all cases. Eighty-three percent of eyes were culture positive. Streptococci were the most frequent causative organisms, isolated from 57% of culture positive eyes. Twenty-three percent of eyes grew @entity6932 . Only two cases were caused by staphylococci. In general, the visual outcome was poor, probably primarily due to the virulence of the infecting organisms. Endophthalmitis remains a risk even many years after creation of a filtering @entity4530 . The microbiologic spectrum in this clinical setting is considerably different from that of recent @entity86 . Based on the bacteriology and clinical course of the @entity1 presented, recommendations for management are discussed.

title: Late onset XXXX associated with filtering @entity4530 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6932 :: ('MESH:D008583', 'Disease') :: ['Hemophilus influenzae']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative endophthalmitis']

entities_list: @entity3225 :: ('MESH:D009877', 'Disease') :: ['endophthalmitis']

answer: @entity3225 :: (MESH:D009877,Disease) :: ['endophthalmitis']


abstract: Thirty-six cases of late onset @entity3225 in @entity1 with filtering @entity4530 are presented. Onset of @entity3225 ranged from 4 months to 60 years after @entity4530 formation. Possible contributing factors could be identified only in a minority of @entity1 . Aqueous, vitreous or both were cultured in all cases. Eighty-three percent of eyes were culture positive. Streptococci were the most frequent causative organisms, isolated from 57% of culture positive eyes. Twenty-three percent of eyes grew @entity6932 . Only two cases were caused by staphylococci. In general, the visual outcome was poor, probably primarily due to the virulence of the infecting organisms. Endophthalmitis remains a risk even many years after creation of a filtering @entity4530 . The microbiologic spectrum in this clinical setting is considerably different from that of recent @entity86 . Based on the bacteriology and clinical course of the @entity1 presented, recommendations for management are discussed.

title: Late onset @entity3225 associated with filtering XXXX .

answer: @entity4530 :: (MESH:D001768,Disease) :: ['blebs']


abstract: OBJECTIVE: Our objective is to investigate the feasibility and validity of a new instrument to screen for determinants of poststroke @entity1295 during the rehabilitation process. DESIGN AND SETTING: This prospective cohort study was conducted within the @entity64 department of a rehabilitation center. @entity1 : The @entity1 in the study were postacute adult @entity64 @entity1 . The Detection List Fatigue (DLF) was administered 2 weeks after the start of the rehabilitation program and again 6 weeks later. MAIN OUTCOME MEASURES: To determine the construct validity, the Hospital Anxiety and @entity308 Scale, the Checklist Individual Strength subscale @entity1295 , and the Fatigue Severity Scale-7-item version were administered. A @entity1295 rating scale was used to measure the @entity1 ' @entity1295 experience. Frequency analyses of the number of @entity1 reporting poststroke @entity1295 according to the DLF were performed. RESULTS: One hundred seven @entity1 (mean age 60 years) without severe communication difficulties were included in the study. The DLF was easy to understand and quick to administer. The DLF showed good internal consistency (Cronbach's alpha: .79 and .87), high convergent validity (rs   =   .85 and rs   =   .79), and good divergent validity (rs   =   .31 and rs   =   .45). The majority of the @entity1 (88.4%-90.2%) experienced at least 2 poststroke @entity1295 (PSF) determinants, of which "sleeping problem" was most frequently reported. CONCLUSIONS: The DLF is a feasible and valid instrument for the screening of PSF determinants throughout the rehabilitation process in @entity64 @entity1 . Future studies should investigate whether the use of the list in determining a treatment plan prevents the development of PSF.

title: XXXX ; Feasibility and Validation of an Instrument for the Screening of Poststroke Fatigue throughout the Rehabilitation Process.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'PARTICIPANTS']

entities_list: @entity1295 :: ('MESH:D005221', 'Disease') :: ['fatigue determinants', 'fatigue']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression']

answer: @entity1295 :: (MESH:D005221,Disease) :: ['Screening Poststroke Fatigue']


abstract: UNASSIGNED: @entity5 survivors often experience poor post-treatment musculoskeletal health. This study examined the feasibility of combined aerobic and resistant training ( @entity18527 ) for improving strength, skeletal health and balance. @entity5 survivors (n  =  24) were identified by convenience sampling in Los Angeles County with 11 survivors consenting to 13  weeks of @entity18527 . Pre- and post-intervention assessments of @entity79 ( @entity79 ), strength, flexibility and biomarker analysis were performed. Paired t-test analysis suggested increases in lower and upper body strength. The average T-score for @entity79 at the femoral neck improved from -1.46 to -1.36 and whole body @entity79 improved from -1.65 to -1.55. From baseline to follow-up, @entity1 also displayed decreases in sway velocity on the eyes open (7%) and eyes closed (27%) conditions. Improvement in lower body strength was associated with increases in lean body mass (LBM) (r  =  0.721) and an inverse association was observed between sway velocity and LBM (r  =  0.838). Age and time since last treatment were related with biomarkers of anabolic growth ( @entity442 , @entity2301 ) and bone (DPD, BAP). In summary, observed physiological changes were consistent with functional improvements, suggesting that isometric and dynamic exercise prescription may reduce the risk for falls and fall-related @entity174 among survivors.

title: Training-related improvements in musculoskeletal health and balance: a 13-week pilot study of female XXXX survivors.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: PURPOSE: We once reported blast-induced @entity131 (bTBI) in confined space. Here, bTBI was studied again on @entity1237 in the open air using 3.0 kg @entity51224 . METHODS: The @entity1237 were placed at 2, 4, 6 and 8 m far from explosion center. @entity51224 ( @entity51224 ) was used as the source of the blast wave and the pressure at each distance was recorded. The systemic physiology, electroencephalogram, serum level of @entity72763 , and @entity72764 ( @entity72764 ) were determined pre and post the exposure. Neuroanatomy and neuropathology were observed 4 h after the exposure. RESULTS: Simple blast waveforms were recorded with parameters of 702.8 kPa-0.442 ms, 148.4 kPa-2.503 ms, 73.9 kPa-3.233 ms, and 41.9 kPa-5.898 ms at 2, 4, 6 and 8 m respectively. Encephalic blast overpressure was on the first time recorded in the literature by us at 104.2 kPa-0.60 ms at 2 m, where mortality and burn rate were 44% and 44%. Gross examination showed that bTBI was mainly manifested as congestive expansion of blood vessels and @entity510 , which had a total incidence of 25% and 19% in 36 @entity1237 . Microscopical observation found that the main pathohistological changes were enlarged perivascular space (21/36, 58%), small @entity548 (9/36, 25%), @entity384 and congestion (8/36, 22%), and less @entity510 (2/36, 6%). After explosion, serum levels of @entity72763 and @entity72764 were elevated, and EEG changed into slow frequency with declined amplitude. The results indicated that severity and incidence of bTBI is related to the intensity of blast overpressure. CONCLUSION: Blast wave can pass through the skull to directly injure brain tissue.

title: An open air research study of blast-induced XXXX to @entity1237 .

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhages']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['vascular dilatation']

entities_list: @entity51224 :: ('MESH:D014303', 'Chemical') :: ['TNT', 'Trinitrotoluene', 'trinitrotoluene']

entities_list: @entity72764 :: ('102190860', 'Gene') :: ['NSE', 'neuron specific enolase']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: PURPOSE: We once reported blast-induced @entity131 (bTBI) in confined space. Here, bTBI was studied again on @entity1237 in the open air using 3.0 kg @entity51224 . METHODS: The @entity1237 were placed at 2, 4, 6 and 8 m far from explosion center. @entity51224 ( @entity51224 ) was used as the source of the blast wave and the pressure at each distance was recorded. The systemic physiology, electroencephalogram, serum level of @entity72763 , and @entity72764 ( @entity72764 ) were determined pre and post the exposure. Neuroanatomy and neuropathology were observed 4 h after the exposure. RESULTS: Simple blast waveforms were recorded with parameters of 702.8 kPa-0.442 ms, 148.4 kPa-2.503 ms, 73.9 kPa-3.233 ms, and 41.9 kPa-5.898 ms at 2, 4, 6 and 8 m respectively. Encephalic blast overpressure was on the first time recorded in the literature by us at 104.2 kPa-0.60 ms at 2 m, where mortality and burn rate were 44% and 44%. Gross examination showed that bTBI was mainly manifested as congestive expansion of blood vessels and @entity510 , which had a total incidence of 25% and 19% in 36 @entity1237 . Microscopical observation found that the main pathohistological changes were enlarged perivascular space (21/36, 58%), small @entity548 (9/36, 25%), @entity384 and congestion (8/36, 22%), and less @entity510 (2/36, 6%). After explosion, serum levels of @entity72763 and @entity72764 were elevated, and EEG changed into slow frequency with declined amplitude. The results indicated that severity and incidence of bTBI is related to the intensity of blast overpressure. CONCLUSION: Blast wave can pass through the skull to directly injure brain tissue.

title: An open air research study of blast-induced @entity131 to XXXX .

answer: @entity1237 :: (9925,Species) :: ['goats']


abstract: BACKGROUND: @entity13593 in dermatology consist of intentionally self-inflicted @entity272 that vary in morphology and distribution and occur on surfaces readily accessible to the @entity1 's hands. They tend to be a chronic condition that waxes and wanes according to the circumstances of the @entity1 's life. @entity1 management poses a particular challenge to the clinician and the prognosis is considered poor. The aetiopathogenesis of @entity13593 in dermatology is not completely understood. We present a case in which we suggested the occurrence of factitious behaviour during a dissociative state, and we briefly describe our diagnostic and therapeutic approach. @entity1 AND METHODS: A 48-year-old unemployed @entity1 was referred to our department of psychiatry by her dermatologist for suspected @entity13593 . The @entity1 was diagnosed with @entity6 and had been hospitalized repeatedly for confirmed @entity6 . The onset of the disease was related to marital discord with her spouse. Numerous @entity272 had appeared on her face, arms, legs, neck and back. These lesions resulted in multiple hospital admissions and in amputation of her left leg. The condition had worsened considerably after her separation from her husband. During the initial conversation, the @entity1 was unable to provide a clear history of the disease. She denied any knowledge of the circumstances in which these @entity272 appeared, and she did not admit self-infliction. Her mood was depressed and her speech was slow. We suspected that our @entity1 was herself causing her @entity272 while in a dissociative state. Several arguments militate in favour of our hypothesis, particularly her history of childhood maltreatment and the association of traumatic life events with simultaneous deterioration of the skin. The explanation of the dissociative mechanism helped us to strengthen the therapeutic relationship. Within a few days, we noted a slow regression of the lesions, but the @entity1 was still unable to explain how the lesions had occurred. DISCUSSION: The pathophysiology of @entity13593 in dermatology is poorly understood. It has strong ties with other @entity146 , and according to several authors, @entity272 occur in dissociative states, after which @entity1 do not remember how the skin change started. Management of this disease is challenging. An improved understanding of its mechanisms may enhance the prognosis for this particular group of @entity1 .

title: [ XXXX in dermatology: Value of the dissociative state concept].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient', 'PATIENTS', 'Patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic ketoacidosis', 'diabetes mellitus type 1']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders']

entities_list: @entity13593 :: ('MESH:D005162', 'Disease') :: ['factitious disorder', 'factitious disorders', 'Factitious disorders']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions']

answer: @entity13593 :: (MESH:D005162,Disease) :: ['Factitious disorders']


abstract: INTRODUCTION: The American Academy of Pediatrics recommends operating on @entity2650 between the ages of 6-12 months. Since most births in developed countries are conducted in a hospital, parents are likely to be well informed and counseled about the @entity2650 . However, significant numbers of births in developing countries are still conducted at home, with illiteracy, poverty and ignorance often leading to late presentation at the hospital. Reported @entity2650 -repair complication rates are higher in adults compared with those having surgery in childhood. The present study's objective was to evaluate the factors affecting surgical outcome in @entity2650 @entity1 undergoing tubularized and tubularized incised plate urethroplasty (TIPU) in adulthood compared with childhood. MATERIALS AND METHODS: A prospective study of 60 adult @entity1 >16 years, and 60 pediatric @entity1 <5 years who underwent TIPU for @entity2650 between May 2008 and May 2012. @entity1 were operated on by a single surgeon, under similar circumstances, and were pre-operatively examined to assess meatal location, chordee, and torsion; they were also examined intra-operatively for quality of spongiosum and urethral plate width. The outcomes were assessed by @entity1 /parents for satisfaction regarding cosmesis, urinary stream and complications. RESULTS: The age of the @entity1 varied from 16 to 27 years, with a mean of 20.8 years in adults, and 6 months to 5 years, with a mean of 2.1 years, in @entity1 . The type of @entity2650 , degree of curvature, quality of spongiosum and urethral plate width were comparable in both groups, but complication rates were higher in adults (16.7%) than in the pediatric (6.7%) group (Figure  1A-D). @entity850 responded well to dilatation, but fistulae required revision surgery and had a cure rate of 100%. The median follow-up was 37 months in adults, and 39 months in @entity1 . DISCUSSION: The higher complication rates in adults may be due to more frequent erections; increased susceptibility to @entity281 along with relatively reduced vascularity lead to poor wound healing and increased complication rates. The limitation of the study was the small number of @entity1 with mid and proximal @entity2650 having lesser incidences in comparison with @entity2650 . Adequate number of @entity1 in these subgroups could have further strengthened the statistical correlation. Secondly, there was no objective criterion like uroflowmetry to assess urinary stream. CONCLUSIONS: Complication rates were higher in adults undergoing TIPU compared with pediatric @entity1 , which was also statistically significant in @entity2650 . The important factors in surgical outcome were: severity of @entity2650 , degree of curvature, quality of spongiosum, and urethral plate width.

title: Comparison of variables affecting the surgical outcomes of tubularized incised plate urethroplasty in adult and pediatric XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['Meatal stenosis']

entities_list: @entity2650 :: ('MESH:D007021', 'Disease') :: ['distal hypospadias', 'primary hypospadias', 'hypospadias']

answer: @entity2650 :: (MESH:D007021,Disease) :: ['hypospadias']


abstract: UNASSIGNED: We compared the performance of several prediction techniques for @entity0 prognosis, based on AU-ROC performance (Area Under ROC) for different prognosis periods. The analyzed dataset contained 1,981 @entity1 and from an initial 25 variables, the 11 most common clinical predictors were retained. We compared eight models from a wide spectrum of predictive models, namely; Generalized Linear Model (GLM), GLM-Net, Partial Least Square (PLS), Support Vector Machines (SVM), Random Forests (RF), Neural Networks, k-Nearest Neighbors (k-NN) and Boosted Trees. In order to compare these models, paired t-test was applied on the model performance differences obtained from data resampling. Random Forests, Boosted Trees, Partial Least Square and GLMNet have superior overall performance, however they are only slightly higher than the other models. The comparative analysis also allowed us to define a relative variable importance as the average of variable importance from the different models. Two sets of variables are identified from this analysis. The first includes number of positive lymph nodes, @entity5 size, @entity5 grade and @entity172 receptor, all has an important influence on model predictability. The second set incudes variables related to histological parameters and treatment types. The short term vs long term contribution of the clinical variables are also analyzed from the comparative models. From the various @entity5 treatment plans, the combination of Chemo/Radio therapy leads to the largest impact on @entity5 prognosis.

title: Model Comparison for XXXX Prognosis Based on Clinical Data.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']


abstract: INTRODUCTION: Image-guided interstitial (IRT) brachytherapy (BRT) is an effective treatment option as part of a multimodal approach to the treatment of isolated @entity2 . In this study, we report our results of computed tomography-guided IRT high-dose-rate (HDR) BRT in the local treatment of inoperable primary and secondary intrathoracic @entity5 . METHODS: Between 1997 and 2007, 55 @entity1 underwent a total of 68 interventional procedures for a total of 60 lung lesions. The median @entity5 volume was 160 cm   (range, 24-583 cm  ). Thirty-seven @entity1 were @entity1 and 18 were @entity1 , with a median age of 64 years (range, 31-93 years). The IRT-HDR-BRT delivered a median dose of 25.0 Gy (range, 10.0-32.0 Gy) in twice-daily fractions of 4.0 to 15.0 Gy in 27 @entity1 and 10.0 Gy (range, 7.0-32.0 Gy) in once-daily fractions of 4.0 to 20.0 Gy in 28 @entity1 . RESULTS: The median follow-up was 14 months (range, 1-49 months). The overall survival rate was 63% at 1 year, 26% at 2 years, and 7% at 3 years. The local control rate for @entity3 was 93%, 82%, and 82% and for primary @entity5 86%, 79%, and 73% at 1, 2, and 3 years, respectively. Pneumothoraces occurred in 11.7% of interventional procedures, necessitating postprocedural drainage in one (1.8%) @entity1 . CONCLUSIONS: In @entity1 with inoperable intrathoracic @entity5 , computed tomography-guided IRT-HDR-BRT is a safe and effective alternative to other locally ablative techniques.

title: Computed tomography-guided interstitial high-dose-rate brachytherapy in the local treatment of primary and secondary intrathoracic XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'intrathoracic cancers', 'malignancies']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic tumors']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignancies']


abstract: Rapid bedside determination of cerebral blood pressure autoregulation (AR) may improve clinical utility. We tested the hypothesis that cerebral Hb oxygenation (HbDiff) and cerebral Hb volume (HbTotal) measured by near-infrared spectroscopy (NIRS) would correlate with cerebral blood flow (CBF) after single dose @entity2647 (PE). @entity3124 @entity1 requiring artificial ventilation and arterial lines were eligible. During rapid blood pressure rise induced by i.v. PE bolus, /\HbDiff and /\HbTotal were calculated by subtracting values at baseline (normotension) from values at peak blood pressure elevation ( @entity101 ). With the aid of NIRS and bolus injection of @entity3194 , relative measures of CBF, called blood flow index (BFI), were determined during normotension and during @entity101 . BFI during @entity101 was expressed as percentage from BFI during normotension (BFI%). Autoregulation indices (ARIs) were calculated by dividing BFI%, /\HbDiff, and /\HbTotal by the concomitant change in blood pressure. In 24 @entity1 (11 newborns and 13 @entity1 ), significant correlations between BFI% and /\HbDiff (or /\HbTotal) were found. In addition, the associations between Hb-based ARI and BFI%-based ARI were significant with correlation coefficients of 0.73 (or 0.72). Rapid determination of dynamic AR with the aid of cerebral Hb signals and PE bolus seems to be reliable.

title: Rapid assessment of cerebral autoregulation by near-infrared spectroscopy and a single dose of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['Critically ill']

entities_list: @entity3194 :: ('MESH:D007208', 'Chemical') :: ['indocyanine green']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine']

answer: @entity2647 :: (MESH:D010656,Chemical) :: ['phenylephrine']


abstract: Common fragile sites have long been identified by cytogeneticists as chromosomal regions prone to breakage upon replication stress. They are increasingly recognized to be preferential targets for oncogene-induced DNA damage in pre-neoplastic lesions and hotspots for chromosomal rearrangements in various @entity5 . Common fragile site instability was attributed to the fact that they contain sequences prone to form secondary structures that may impair replication fork movement, possibly leading to fork collapse resulting in DNA breaks. Here we show, in contrast to this view, that the fragility of @entity21900 --the most active common fragile site in @entity1 lymphocytes--does not rely on fork slowing or stalling but on a paucity of initiation events. Indeed, in lymphoblastoid cells, but not in fibroblasts, initiation events are excluded from a @entity21900 core extending approximately 700 kilobases, which forces forks coming from flanking regions to cover long distances in order to complete replication. We also show that origins of the flanking regions fire in mid-S phase, leaving the site incompletely replicated upon fork slowing. Notably, @entity21900 instability is specific to cells showing this particular initiation pattern. The fact that both origin setting and replication timing are highly plastic in @entity1 cells explains the tissue specificity of common fragile site instability we observed. Thus, we propose that common fragile sites correspond to the latest initiation-poor regions to complete replication in a given cell type. For historical reasons, common fragile sites have been essentially mapped in lymphocytes. Therefore, common fragile site contribution to chromosomal rearrangements in @entity5 should be reassessed after mapping fragile sites in the cell type from which each @entity5 originates.

title: Cell-type-specific replication initiation programs set fragility of the XXXX fragile site.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'tumours', 'tumour']

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian', 'human']

answer: @entity21900 :: (2272,Gene) :: ['FRA3B']


abstract: OBJECTIVES: The aim of the first @entity1073 ( @entity1073 ) protocol was to study the clinical significance of an augmented @entity3726 induction chemotherapy followed by high-dose chemotherapy and autologous stem cell transplantation (ASCT) and to examine the prognostic significance of stem cell contamination rates in newly diagnosed @entity1 with @entity1073 . @entity1 AND METHODS: Forty-one newly diagnosed @entity1 below 66 yr were enrolled and given three series of an augmented @entity3726 regimen. Responders underwent stem cell mobilization with a fourth course of @entity3726 , stem cell harvest and ASCT. Stem cell purging was optional in the protocol and followed the routine of each participating centre. The number of @entity5 cells in the reinfused autografts was estimated by flow cytometry or quantitative PCR. RESULTS: Induction therapy led to complete remission (CR) in 11 of 41 @entity1 (27%), partial remission (PR) in 20 of 41 @entity1 (49%) and no response in nine @entity1 (22%), whereas one @entity1 was not evaluable. Twenty-seven of the 31 responders underwent ASCT and 24 achieved or maintained a CR. The overall and failure-free 4-yr survival on intention-to-treat basis were 51% and 15%, respectively. Among the transplanted @entity1 , a significantly increased failure-free (P<0.03) and overall survival (P=0.03) was noted among @entity1 transplanted in CR compared with PR, respectively. By contrast, reinfusion of highly variable numbers of @entity5 cells with the autografts (range 0.71-80 x 10(6) @entity5 cells), did not affect outcome. CONCLUSION: In @entity1073 , an important strategy to improve the outcome will be to intensify the induction chemotherapy.

title: Primary treatment with autologous stem cell transplantation in XXXX : outcome related to remission pretransplant.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity1073 :: ('MESH:D020522', 'Disease') :: ['Nordic mantle cell lymphoma', 'MCL']

answer: @entity1073 :: (MESH:D020522,Disease) :: ['mantle cell lymphoma']


abstract: The efficacy and @entity137 of combination chemotherapy with @entity1205 + @entity3003 were evaluated in @entity1 with locally advanced or recurrent @entity5 . A total of 71 @entity1 with @entity5 were enrolled into this trial, and 66 @entity1 were considered eligible. The @entity1 were administered @entity1205 at 60 mg/m2 followed by @entity3003 based on area under the curve of 6, both by intravenous infusion, every 3 weeks, with the treatment repeated for 1 to 6 cycles depending on the goal of the therapy. The response was evaluated based on the Response Evaluation Criteria in @entity5 criteria. @entity137 to chemotherapy was evaluated according to the National @entity5 Institute Common @entity137 Criteria. Of the 66 eligible @entity1 , 62 had locally @entity5 with no history of previous treatment, whereas 4 @entity1 had recurrent @entity5 . A total 149 cycles of chemotherapy were administered, with a median of 2.3 cycles (range, 1-6) per @entity1 . The overall clinical response rate was 63.7% (44/66, 95% confidence interval, 52.1-75.3). In the neoadjuvant chemotherapy setting, the overall clinical response rate was 69.3% (43/62; 43/62, 95% confidence interval, 57.8-80.8), and the response rates in @entity1 with @entity957 and @entity1358 were 69.7% (23/33, 95% confidence interval, 54.0-85.4) and 68.9% (20/29, 95% confidence interval, 52.1-85.7), respectively. On the other hand, in @entity1 with recurrent @entity5 , the overall response rate was 25.0% (1/4, 95% confidence interval, -17.4 to 67.4). Nonhematological @entity137 were mainly grade 1 or 2. @entity1503 was encountered mostly in the form of @entity1398 and @entity882 . Combination chemotherapy with @entity1205 + @entity3003 is a safe and well-tolerated treatment for @entity1 with @entity5 and is effective against not only @entity957 , but also @entity420 .

title: Phase II study of combination chemotherapy with @entity1205 and XXXX for locally advanced or recurrent @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity', 'toxicities']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['advanced cervical cancer', 'Solid Tumors', 'cervical cancer', 'Cancer']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['Hematological toxicity']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['nonsquamous cell carcinoma']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']

answer: @entity3003 :: (MESH:D016190,Chemical) :: ['carboplatin']


abstract: The efficacy and @entity137 of combination chemotherapy with @entity1205 + @entity3003 were evaluated in @entity1 with locally advanced or recurrent @entity5 . A total of 71 @entity1 with @entity5 were enrolled into this trial, and 66 @entity1 were considered eligible. The @entity1 were administered @entity1205 at 60 mg/m2 followed by @entity3003 based on area under the curve of 6, both by intravenous infusion, every 3 weeks, with the treatment repeated for 1 to 6 cycles depending on the goal of the therapy. The response was evaluated based on the Response Evaluation Criteria in @entity5 criteria. @entity137 to chemotherapy was evaluated according to the National @entity5 Institute Common @entity137 Criteria. Of the 66 eligible @entity1 , 62 had locally @entity5 with no history of previous treatment, whereas 4 @entity1 had recurrent @entity5 . A total 149 cycles of chemotherapy were administered, with a median of 2.3 cycles (range, 1-6) per @entity1 . The overall clinical response rate was 63.7% (44/66, 95% confidence interval, 52.1-75.3). In the neoadjuvant chemotherapy setting, the overall clinical response rate was 69.3% (43/62; 43/62, 95% confidence interval, 57.8-80.8), and the response rates in @entity1 with @entity957 and @entity1358 were 69.7% (23/33, 95% confidence interval, 54.0-85.4) and 68.9% (20/29, 95% confidence interval, 52.1-85.7), respectively. On the other hand, in @entity1 with recurrent @entity5 , the overall response rate was 25.0% (1/4, 95% confidence interval, -17.4 to 67.4). Nonhematological @entity137 were mainly grade 1 or 2. @entity1503 was encountered mostly in the form of @entity1398 and @entity882 . Combination chemotherapy with @entity1205 + @entity3003 is a safe and well-tolerated treatment for @entity1 with @entity5 and is effective against not only @entity957 , but also @entity420 .

title: Phase II study of combination chemotherapy with @entity1205 and @entity3003 for locally advanced or recurrent XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']


abstract: The efficacy and @entity137 of combination chemotherapy with @entity1205 + @entity3003 were evaluated in @entity1 with locally advanced or recurrent @entity5 . A total of 71 @entity1 with @entity5 were enrolled into this trial, and 66 @entity1 were considered eligible. The @entity1 were administered @entity1205 at 60 mg/m2 followed by @entity3003 based on area under the curve of 6, both by intravenous infusion, every 3 weeks, with the treatment repeated for 1 to 6 cycles depending on the goal of the therapy. The response was evaluated based on the Response Evaluation Criteria in @entity5 criteria. @entity137 to chemotherapy was evaluated according to the National @entity5 Institute Common @entity137 Criteria. Of the 66 eligible @entity1 , 62 had locally @entity5 with no history of previous treatment, whereas 4 @entity1 had recurrent @entity5 . A total 149 cycles of chemotherapy were administered, with a median of 2.3 cycles (range, 1-6) per @entity1 . The overall clinical response rate was 63.7% (44/66, 95% confidence interval, 52.1-75.3). In the neoadjuvant chemotherapy setting, the overall clinical response rate was 69.3% (43/62; 43/62, 95% confidence interval, 57.8-80.8), and the response rates in @entity1 with @entity957 and @entity1358 were 69.7% (23/33, 95% confidence interval, 54.0-85.4) and 68.9% (20/29, 95% confidence interval, 52.1-85.7), respectively. On the other hand, in @entity1 with recurrent @entity5 , the overall response rate was 25.0% (1/4, 95% confidence interval, -17.4 to 67.4). Nonhematological @entity137 were mainly grade 1 or 2. @entity1503 was encountered mostly in the form of @entity1398 and @entity882 . Combination chemotherapy with @entity1205 + @entity3003 is a safe and well-tolerated treatment for @entity1 with @entity5 and is effective against not only @entity957 , but also @entity420 .

title: Phase II study of combination chemotherapy with XXXX and @entity3003 for locally advanced or recurrent @entity5 .

answer: @entity1205 :: (MESH:C067311,Chemical) :: ['docetaxel']


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity6313 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity2059 pulse therapy combined with @entity20517 with @entity2059 alone in the treatment of Candida fingernail @entity6313 . METHODS: Ninety @entity1 with moderate to severe Candida fingernail @entity6313 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity2059 pulse therapy for 2 months and applied @entity20517 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity2059 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity1 were analysed (73 @entity1 and 12 @entity1 , mean +/- SD age 44.2 +/- 12.9 years). @entity1 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity6313 was 11 months. Paronychial involvement was evident in 71 @entity1 . @entity5132 was isolated in 85 cases, @entity7409 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity1 in group 1 and in 25 (60%) of 42 @entity1 in group 2. At the 9-month visit, a global cure was seen in 40 @entity1 (93%) in group 1 and in 34 @entity1 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity7634 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity20517 and oral @entity2059 , which interfere with different steps of @entity12364 synthesis, exhibited substantial synergy. Compared with oral @entity2059 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity20517 and two pulses of @entity2059 is at least as safe and effective as three pulses of @entity2059 , with a lower cost per @entity1 . In our opinion, the addition of @entity20517 to oral @entity2059 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity6313 .

title: A randomized trial of XXXX 5% solution nail lacquer in association with @entity2059 pulse therapy compared with @entity2059 alone in the treatment of Candida fingernail @entity6313 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'men']

entities_list: @entity12364 :: ('MESH:D004875', 'Chemical') :: ['ergosterol']

entities_list: @entity6313 :: ('MESH:D014009', 'Disease') :: ['onychomycosis']

entities_list: @entity7409 :: ('5480', 'Species') :: ['C. parapsilosis']

entities_list: @entity20517 :: ('MESH:C038974', 'Chemical') :: ['amorolfine']

entities_list: @entity2059 :: ('MESH:D017964', 'Chemical') :: ['itraconazole']

answer: @entity20517 :: (MESH:C038974,Chemical) :: ['amorolfine']


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity6313 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity2059 pulse therapy combined with @entity20517 with @entity2059 alone in the treatment of Candida fingernail @entity6313 . METHODS: Ninety @entity1 with moderate to severe Candida fingernail @entity6313 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity2059 pulse therapy for 2 months and applied @entity20517 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity2059 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity1 were analysed (73 @entity1 and 12 @entity1 , mean +/- SD age 44.2 +/- 12.9 years). @entity1 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity6313 was 11 months. Paronychial involvement was evident in 71 @entity1 . @entity5132 was isolated in 85 cases, @entity7409 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity1 in group 1 and in 25 (60%) of 42 @entity1 in group 2. At the 9-month visit, a global cure was seen in 40 @entity1 (93%) in group 1 and in 34 @entity1 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity7634 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity20517 and oral @entity2059 , which interfere with different steps of @entity12364 synthesis, exhibited substantial synergy. Compared with oral @entity2059 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity20517 and two pulses of @entity2059 is at least as safe and effective as three pulses of @entity2059 , with a lower cost per @entity1 . In our opinion, the addition of @entity20517 to oral @entity2059 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity6313 .

title: A randomized trial of @entity20517 5% solution nail lacquer in association with @entity2059 pulse therapy compared with @entity2059 alone in the treatment of Candida fingernail XXXX .

answer: @entity6313 :: (MESH:D014009,Disease) :: ['onychomycosis']


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity6313 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity2059 pulse therapy combined with @entity20517 with @entity2059 alone in the treatment of Candida fingernail @entity6313 . METHODS: Ninety @entity1 with moderate to severe Candida fingernail @entity6313 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity2059 pulse therapy for 2 months and applied @entity20517 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity2059 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity1 were analysed (73 @entity1 and 12 @entity1 , mean +/- SD age 44.2 +/- 12.9 years). @entity1 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity6313 was 11 months. Paronychial involvement was evident in 71 @entity1 . @entity5132 was isolated in 85 cases, @entity7409 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity1 in group 1 and in 25 (60%) of 42 @entity1 in group 2. At the 9-month visit, a global cure was seen in 40 @entity1 (93%) in group 1 and in 34 @entity1 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity7634 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity20517 and oral @entity2059 , which interfere with different steps of @entity12364 synthesis, exhibited substantial synergy. Compared with oral @entity2059 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity20517 and two pulses of @entity2059 is at least as safe and effective as three pulses of @entity2059 , with a lower cost per @entity1 . In our opinion, the addition of @entity20517 to oral @entity2059 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity6313 .

title: A randomized trial of @entity20517 5% solution nail lacquer in association with XXXX pulse therapy compared with @entity2059 alone in the treatment of Candida fingernail @entity6313 .

answer: @entity2059 :: (MESH:D017964,Chemical) :: ['itraconazole']


abstract: BACKGROUND: Treatment failures and relapses are not uncommon in @entity6313 . Therefore, it is worthwhile to consider the combination of systemic and topical antifungals to improve the cure rates further and to reduce the duration of systemic treatment. OBJECTIVES: To evaluate and compare @entity2059 pulse therapy combined with @entity20517 with @entity2059 alone in the treatment of Candida fingernail @entity6313 . METHODS: Ninety @entity1 with moderate to severe Candida fingernail @entity6313 were randomized into two treatment groups of 45 subjects each. Group 1 received @entity2059 pulse therapy for 2 months and applied @entity20517 5% solution nail lacquer for 6 months, while group 2 received monotherapy with three pulses of @entity2059 . The primary efficacy criterion was the result of mycological examination at 3 months. The secondary criterion was the combined mycological and clinical response at 9 months. A pharmacoeconomic analysis was also performed to compare the cost-effectiveness of combined therapy vs. monotherapy. RESULTS: Eighty-five @entity1 were analysed (73 @entity1 and 12 @entity1 , mean +/- SD age 44.2 +/- 12.9 years). @entity1 had a mean +/- SD of 3.64 +/- 2.0 nails involved and 228.6 +/- 148.0 mm2 of their nail surface diseased. The mean duration of @entity6313 was 11 months. Paronychial involvement was evident in 71 @entity1 . @entity5132 was isolated in 85 cases, @entity7409 in three and other Candida species in two cases. Side-effects were uncommon and in only one case led to withdrawal. At the 3-month visit, mycological cure was seen in 32 (74%) of 43 @entity1 in group 1 and in 25 (60%) of 42 @entity1 in group 2. At the 9-month visit, a global cure was seen in 40 @entity1 (93%) in group 1 and in 34 @entity1 (81%) in group 2. Statistical analysis showed no statistically significant difference (P > 0.1) between the two treatment groups. The cost per cure ratio was 1.63 and 1.70 @entity7634 for groups 1 and 2, respectively. CONCLUSIONS: The combination of @entity20517 and oral @entity2059 , which interfere with different steps of @entity12364 synthesis, exhibited substantial synergy. Compared with oral @entity2059 alone, the combination achieved greater mycological cure and increased total cure rate. However, no statistically significant difference was documented for this number of observations. Combination treatment with @entity20517 and two pulses of @entity2059 is at least as safe and effective as three pulses of @entity2059 , with a lower cost per @entity1 . In our opinion, the addition of @entity20517 to oral @entity2059 pulse therapy is of value in the treatment of moderate to severe Candida fingernail @entity6313 .

title: A randomized trial of @entity20517 5% solution nail lacquer in association with @entity2059 pulse therapy compared with XXXX alone in the treatment of Candida fingernail @entity6313 .

answer: @entity2059 :: (MESH:D017964,Chemical) :: ['itraconazole']


abstract: INTRODUCTION: We describe a case of early and persistent reverse end-diastolic flow in the middle cerebral artery in a fetus with severe @entity843 . These features are associated with a rare @entity99 known as @entity513 . CASE PRESENTATION: A 28-year-old Caucasian @entity1 was referred to our high-risk obstetric unit at 24 weeks' gestation for @entity2241 detected during a routine ultrasound examination. During her hospitalization we performed medical investigations, including a fetal paracentesis, to detect the etiology of @entity2241 . The cause of @entity2241 (then considered non-immune or idiopathic) was not evident, but a subsequent ultrasound examination at 27 weeks' gestation showed a reverse end-diastolic flow in the middle cerebral artery without any other @entity854 . A cesarean section was performed at 28 weeks' gestation because of the compromised fetal condition. An autopsy revealed a rare @entity600 of intrahepatic bile ducts known as @entity513 . CONCLUSION: Persistent reverse flow in the middle cerebral artery should be considered a marker of adverse pregnancy outcome. We recommend careful ultrasound monitoring in the presence of this ultrasonographic sign to exclude any other cause of @entity428 . To better understand the nature of these ultrasonographic signs, additional reports are deemed necessary. In fact in our case, as confirmed by histopathological examination, the fetal condition was extremely compromised due to failure of the fetal liver. @entity513 altered the liver structures causing @entity9427 and probably portal @entity101 . These two conditions therefore explain the severe @entity4 that compromised the fetal situation.

title: Reverse end-diastolic flow in a fetus with a rare XXXX : a case report.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['increased intracranial pressure']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['hydrops']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformation']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['Ductal plate malformation', 'ductal plate malformation']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['Doppler abnormalities']

entities_list: @entity9427 :: ('MESH:D007019', 'Disease') :: ['hypoproteinemia']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['liver malformation']

entities_list: @entity2241 :: ('MESH:D005315', 'Disease') :: ['fetal ascites']

answer: @entity99 :: (MESH:D056486,Disease) :: ['liver malformation']


abstract: BACKGROUND: Navarre, in Northern Spain, is an area with moderate exposure to olive and ash tree pollen. OBJECTIVE: To assess the relevance of ash as a cause of @entity2023 in our region. METHODS: The study sample comprised 85 @entity1 from Navarre with clinical symptoms of @entity2023 . Specific immunoglobulin E (sIgE) was determined to Fra e 1, Ole e 1, and a mixture of @entity1472 - and @entity1473 -terminal domains of Ole e 9 (Ole e 9 NC) (ADVIA-Centaur). At the same time, the presence of sIgE to other pollen allergens was studied. Prick tests were performed with ash pollen (n=33) and olive pollen (n=85) and the symptomatic period was recorded (n=85). As a control group, we studied the serum of 98 @entity1 with olive pollen allergy, intense exposure to olive pollen, and no exposure to ash. RESULTS: Sensitization to Oleaceae was detected in 24/85 @entity1 in the study group (28.2%). In this group, the mean (SD) level of IgE to Fra e 1 was 8.5 (10) kU(A)/L and to Ole e 16.07 (7.88) kU(A)/L (P < .001). In the control group, these figures were 103.64 (132.19) kU(A)/L and 86.43 (118.5) kU(A)/L (P < .001), respectively. In all @entity1 with positive sIgE to Fra e 1, IgE to Ole e 1 was also detected (concordance index, kappa = 1), both in the study group and in the control group. @entity1 who were sensitized to Fra e 1 did not present a longer symptomatic period and their symptoms did not have an earlier onset. CONCLUSION: We did not find evidence of clinically relevant sensitization to ash in Navarre.

title: Oleaceae-induced XXXX in an area with exposure to olive and ash trees.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['pollinosis']

entities_list: @entity1473 :: ('CHEBI:46883', 'Chemical') :: ['carboxy']

answer: @entity2023 :: (MESH:D006255,Disease) :: ['pollinosis']


abstract: Diets higher in protein content result in increased satiety and energy expenditure. In the short term, gelatin showed stronger hunger suppression and less subsequent energy intake compared with other proteins. The present study investigated whether a supra-sustained gelatin-milk protein (GMP) diet promotes @entity353 compared with a sustained milk protein ( @entity72765 ) diet and a supra-sustained milk protein (SSMP) diet during an 8-week diet period. A total of seventy-two healthy subjects (31  2 (sd 4  8)  kg/m2; 43 (sd 10) years) followed one of the three diets in a subject-specific amount: @entity72765 , SSMP or @entity8077 diet. During weeks 1-4, energy intake was 100  % of individual energy requirement: 10, 40 and 50  % of energy (En  %) as protein, fat and @entity1735 , respectively ( @entity72765 diet), and 20, 30 and 50  En  % as protein, fat and @entity1735 , respectively (SSMP diet or GMP diet). During weeks 5-8, energy intake was 33  % of individual energy requirement: 30, 35 and 35  En  % as protein, fat and @entity1735 , respectively ( @entity72765 diet), and 60, 5 and 35  En  % as protein, fat and @entity1735 , respectively (SSMP diet or GMP diet). Thus, absolute protein intake was kept constant throughout per subject. Significant decreases in BMI (P  <  0  0001) were similar between the GMP (  -  1  7 (sd 0  5)  kg/m2) and the @entity72765 (  -  2  1 (sd 0  8)  kg/m2) and SSMP (  -  1  6 (sd 0  5)  kg/m2) diets. Decreases in @entity1386 ( @entity1386 ), fat mass (FM) and FM  %, and increases in @entity1386  % were similar between the GMP and both control diets. Changes in RQ differed (P  <  0  05) between the GMP (  -  0  01 (sd 0  06)) and SSMP (  -  0  04 (sd 0  04)) diets. Changes in HDL concentrations differed (P  <  0  05) between the GMP (  -  0  21 (sd 0  18)  mmol/l) and the @entity72765 and SSMP diets (  -  0  08 (sd 0  18)  mmol/l and -  0  09 (sd 0  26)  mmol/l, respectively). In conclusion, a gelatin-milk protein diet does not induce more beneficial effects during an 8-week weight-loss period compared with a @entity72765 or SSMP diet.

title: Effects of a supra-sustained gelatin-milk protein diet compared with (supra-)sustained milk protein diets on body- XXXX .

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['fat-free mass', 'FFM']

answer: @entity353 :: (MESH:D015431,Disease) :: ['weight loss']


abstract: Cordyceps sinensis (CS) is a traditional Chinese medicine and health food used to support many organ systems. It is commercially produced by cultivation in a liquid medium or on a solid (grain/ @entity415 ) phase. We tested the effects of hot water extracts of liquid-phase and solid-phase commercially grown CS on its ability to influence proliferation (using Alamar blue, an oxidation/reduction indicator), migration (serial-wounded monolayer photomicroscopy), invasion through collagen gel (fluorometric assay) and @entity3352 -induced apoptosis (active caspase-3 colorimetric assay) of @entity1 @entity694 HT29 cells. An in vivo study used a @entity35 @entity1819 model ( @entity3352 20 mg/kg and 4 h restraint with oral administration). The CS extract stimulated cell proliferation threefold when added at 10  g/ml (P < 0  01). Cell migration increased by 69 % and invasion by 17 % when CS was added at 5 mg/ml (P < 0  01). The results also showed that 93 % of the pro-proliferative activity was soluble in @entity1068 , whereas pro-migratory activity was divided (61:49) into both @entity1068 -soluble and @entity1068 -insoluble sub-fractions. @entity3352 -induced apoptosis was not affected by the presence of CS. CS reduced the amount of @entity1819 by 63 % when administered orally at 20 mg/ml (P < 0  01), the results being similar to using the potent cytoprotective agent epidermal growth factor at 25  g/ml (83 % reduction). We conclude that both methods of cultivated CS possess biological activity when analysed using a variety of gut models of @entity130 . Functional foods, such as CS, could provide a novel approach for the prevention and treatment of @entity130 .

title: Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and @entity35 XXXX .

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric damage', 'gastric injury']

entities_list: @entity3352 :: ('MESH:D007213', 'Chemical') :: ['Indomethacin', 'indomethacin']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injury to the bowel', 'injury and repair']

answer: @entity1819 :: (MESH:D013272,Disease) :: ['gastric damage models of injury']


abstract: Cordyceps sinensis (CS) is a traditional Chinese medicine and health food used to support many organ systems. It is commercially produced by cultivation in a liquid medium or on a solid (grain/ @entity415 ) phase. We tested the effects of hot water extracts of liquid-phase and solid-phase commercially grown CS on its ability to influence proliferation (using Alamar blue, an oxidation/reduction indicator), migration (serial-wounded monolayer photomicroscopy), invasion through collagen gel (fluorometric assay) and @entity3352 -induced apoptosis (active caspase-3 colorimetric assay) of @entity1 @entity694 HT29 cells. An in vivo study used a @entity35 @entity1819 model ( @entity3352 20 mg/kg and 4 h restraint with oral administration). The CS extract stimulated cell proliferation threefold when added at 10  g/ml (P < 0  01). Cell migration increased by 69 % and invasion by 17 % when CS was added at 5 mg/ml (P < 0  01). The results also showed that 93 % of the pro-proliferative activity was soluble in @entity1068 , whereas pro-migratory activity was divided (61:49) into both @entity1068 -soluble and @entity1068 -insoluble sub-fractions. @entity3352 -induced apoptosis was not affected by the presence of CS. CS reduced the amount of @entity1819 by 63 % when administered orally at 20 mg/ml (P < 0  01), the results being similar to using the potent cytoprotective agent epidermal growth factor at 25  g/ml (83 % reduction). We conclude that both methods of cultivated CS possess biological activity when analysed using a variety of gut models of @entity130 . Functional foods, such as CS, could provide a novel approach for the prevention and treatment of @entity130 .

title: Reparative properties of the traditional Chinese medicine Cordyceps sinensis (Chinese caterpillar mushroom) using HT29 cell culture and XXXX @entity1819 .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: South Asia is considered to have a high prevalence of @entity1004 ( @entity1004 ) against @entity1 . Therefore the World Health Organisation has called for context-specific information about @entity1004 from different regions. A scoping review of published and gray literature over the last 35 years was conducted using Arksey and O'Malley's framework. Reported prevalence of @entity1004 in @entity3595 Lanka ranged from 20-72%, with recent reports of rates ranging from 25- 35%. Most research about @entity1004 has been conducted in a few provinces and is based on the experience of legally married @entity1 . Individual, family, and societal risk factors for @entity1004 have been studied, but their complex relationships have not been comprehensively investigated. Health consequences of @entity1004 have been reported, with particular attention to physical health, but @entity1 are likely to underreport sexual violence. @entity1 seek support mainly from informal networks, with only a few visiting agencies to obtain help. Little research has focused on health sector responses to @entity1004 and their effectiveness. More research is needed on how to challenge gendered perceptions about @entity1004 . Researchers should capture the experience of @entity1 in dating/cohabiting relationships and @entity1 in vulnerable sectors (post-conflict areas and rural areas), and assess how to effectively provide services to them. A critical evaluation of existing services and programmes is also needed to advance evidence informed programme and policy changes in @entity3595 Lanka.

title: Intimate partner violence in XXXX Lanka: a scoping review.

entities_list: @entity1004 :: ('MESH:C563733', 'Disease') :: ['IPV', 'intimate partner violence']

answer: @entity3595 :: (6717,Gene) :: ['Sri']


abstract: AIM. An exposition is given of the data on the incidence of @entity5 in Navarra in the five year period 1988-92, by age and sex groups. MATERIAL AND METHODS. The collection of data of the 1988-92 five year period was carried out in an active form in the information sources. The procedures for collection, control of duplicates and processing of previous years were maintained. Both the indicators of quality and the calculations of the different rates were obtained following the recommendations proposed by the International Agency of @entity5 Research (IARC). RESULTS. Between 1988 and 1992 11,608 incident cases of @entity5 were registered in Navarra. 58% were found in @entity1 . Excluding other @entity1489 , the rate adjusted to the world population was of 274.1 per 100,000 for @entity1 and 182.9 per 100,000 for @entity1 . The localisations where the adjusted rates were higher for @entity1 excluding other @entity1489 were lung, prostate and bladder, and for @entity1 the localisations were breast, uterine corpus and colon. Amongst @entity1 an increasing tendency was noted of @entity150 , and of @entity0 amongst @entity1 . The decrease of @entity5 in both sexes was notable. CONCLUSIONS. Navarra is situated at an intermediate level of incidence with respect to other European countries. In relation to other registers was of note the high rate of @entity5 in @entity1 and the low rate of cervical @entity5 in @entity1 .

title: [Incidence of XXXX in Navarra. 1988-92].

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malign tumours', 'larynx cancer', 'Cancer', 'stomach cancer']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancer']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['cancer of the colon and bladder']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: In a prospective study, 42 048 adults residing in Zhongshan City, Guangdong, China, were followed for 16 years, and 171 of them developed @entity189 ( @entity189 ). Although @entity2025 ( @entity2025 ) antibody levels of the cohort fluctuated, the antibody levels of 93% of the @entity1 with @entity189 were raised and maintained at high levels for up to 10 years prior to diagnosis. This suggests that the serologic window affords an opportunity to monitor @entity5 progression during the preclinical stage of @entity189 development, facilitating early @entity189 detection. We reviewed the clinical records of the 171 @entity1 with @entity189 in the prospective study to assess the efficacy of early @entity189 detection by serologic screening and clinical examination. Of the 171 @entity1 , 51 had Stage I @entity5 (44 were among the 73 @entity1 detected by clinical examination and 7 were among the 98 @entity1 presented to outpatient department). Initial serologic screening predicted 58 (95.1%) of the 61 @entity1 detected within 2 years. The risk of the screened population (58/3093) raised 13 times relative to cohort (61/42 048) during this period. Clinical examination detected all the 58 predicted cases, and 35 (60.3%) of which were diagnosed with Stage I @entity5 . The serologic prediction rate fell to 33.6% (37/110) 2 to 16 years after screening. The proportion of cases detected by clinical examination fell to 40.5% (15/37). The proportion of Stage I @entity5 among the cases detected by clinical examination during both periods remained at about 60%. We concluded that early detection of @entity189 can be accomplished by repeated serologic screening to maintain high prediction rates and by promptly examining screened subjects to detect @entity5 before the symptoms develop.

title: Detection of XXXX by serologic screening and clinical examination.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['nasopharyngeal carcinoma', 'NPC']

entities_list: @entity2025 :: ('MESH:D020031', 'Disease') :: ['Epstein-Barr virus', 'EBV']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Stage I nasopharyngeal carcinoma']


abstract: INTRODUCTION: This is a prospective descriptive study of intervention without aleatory assignation, carried out in the Chantrea Health Centre. Its aim is to determine the characteristics of the smokers who are taking part in two interventions by the Smokers' Aid Program (Programa de Ayuda al Fumador-PAF), and to evaluate the factors that influence the latter's success. MATERIAL AND METHODS: The characteristics of 100 smokers were analyzed. They were offered one of the two PAF interventions: Minimal Intervention 1 (MN1): they are given a support brochure in the first consultations, contacted by telephone after one month and called to consultation after 6 months to measure CO. Minimal Intervention 2 (MN2): the smoker makes 5 consultations of support in giving up smoking (+ or - @entity1239 patches) with the doctor, nurse or social worker indiscriminately. The factors that were influential in abandoning the habit with 65 subjects were evaluated. RESULTS: 60% of the subjects were male with an average age of 41 (DE 29). 29% showed a pathology related to @entity286 , with no relation found between this and the success of the interventions. Those who chose MN2 (38%) had started @entity286 consumption at an earlier age and were more dependent on @entity1239 . Of the 65 smokers who completed the program, 37% continued not to smoke after 6 months. Those who managed to give up smoking were of a greater average age, had spent more years smoking and belonged above all to the MN1 intervention. DISCUSSION: Notable successes are achieved if the actions are carried out by the First Aid Team. We find no significant differences between the characteristics of those who give up smoking and those who do not. Not even a serious pathology, related to @entity286 , is predictive of success. The smoker's dependence on @entity1239 must be taken into account in the intervention.

title: [Giving up the XXXX habit through the application of the Smoker's Aid Program in the Chantrea Health Centre].

entities_list: @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine']

answer: @entity286 :: (4097,Species) :: ['tobacco']


abstract: PURPOSE: A major complication associated with the use of resilient denture liners (RDLs) is a change in @entity3358 over time. In vivo studies on the deterioration of RDLs over time are needed. We aimed to investigate the influence of @entity1 characteristics on the @entity3358 of acrylic-based RDLs (ARDLs) embedded in complete maxillary dentures. We hypothesized that 1 month after application of the ARDLs, the @entity3358 would be influenced by age, saliva condition, occlusal force, smoking, drinking, denture wearing during sleeping, denture cleanser usage, and denture type. METHODS: Thirty complete maxillary denture wearers were recruited after obtaining informed consent. One investigator measured the Shore D @entity3358 of the commercially available ARDLs, Soften (SFT), @entity10751 Soft (FDS), and Bio Liner (BIO) using a Vesmeter(  ). The salivary flow rates and pH values and the occlusal force were measured for all @entity1 before initiation of the study. T-tests and Pearson's correlation coefficients were used for the statistical analyses. A p-value of <0.05 was considered statistically significant. RESULTS: Smoking, wearing dentures while sleeping, use of denture cleansers, and denture type were associated with an increase in the @entity3358 of the RDLs. The resting saliva pH only influenced the @entity3358 of the SFT ARDLs. CONCLUSIONS: Smoking, denture wearing while sleeping, denture cleanser usage, denture type, and resting saliva pH are important predictors of the deterioration of ARDLs over time.

title: The influence of XXXX characteristics on acrylic-based resilient denture liners embedded in maxillary complete dentures.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: BACKGROUND Ventriculoperitoneal shunting is an effective treatment for @entity1276 . @entity281 is a common complication. @entity1327 as an implicated organism is rare. In this report, we describe a @entity1 with cryptococcal @entity281 . CASE REPORT A 52-year-old male with normal pressure @entity1276 , status post implantation of VPS one year prior to the presentation; who was admitted with a fever, lethargy and confusion for three days. He was treated empirically with intravenous @entity6944 and @entity2176 for @entity281 . The CSF analysis from both the lumbar puncture and the VPS was significant for a low white blood count, low @entity413 and high protein. Other work-up including India ink and cryptococcal antigen was unrevealing. He remained febrile despite antibiotic treatment for 5 days. The CSF from the shunt was sent for analysis again and it demonstrated similar results from the prior study, but the culture was now positive for @entity1327 . The @entity1 was started on oral @entity4895 and intravenous liposomal @entity2379 . The VPS was removed and an externalized ventricular catheter was placed. The @entity1 showed rapid resolution of the symptoms. CONCLUSIONS To date, there was a total of nine reported cases of cryptococcal @entity281 upon review of the literature. Our presenting case and the literature review highlight the difficulties in making an accurate diagnosis of cryptococcal @entity281 . There were case reports of false negative cryptococcal antigen tests with culture proven @entity1330 . The CSF culture from the shunt remains a mainstay for identifying cryptococcal @entity281 . @entity281 are rare and early diagnosis and treatment is essential for @entity1 management which involves shunt replacement with concomitant administration of intravenous antifungal medication. High clinical suspicion is crucial and shunt culture preferably from the valve is recommended.

title: Cryptococcal Infection of the Ventriculoperitoneal Shunt in an Immunocompetent XXXX .

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity1330 :: ('MESH:D016919', 'Disease') :: ['cryptococcal meningitis']

entities_list: @entity1327 :: ('5207', 'Species') :: ['Cryptococcus neoformans']

entities_list: @entity6944 :: ('MESH:C043266', 'Chemical') :: ['cefepime']

entities_list: @entity4895 :: ('MESH:D005437', 'Chemical') :: ['flucytosine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['Cryptococcal shunt infections', 'VPS infection', 'Ventriculoperitoneal shunt (VPS) infection', 'shunt infection']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: BACKGROUND _ AIMS: This study investigated the efficacy of gastric electrical stimulation for the treatment of @entity7623 unresponsive to standard medical therapy. METHODS: Thirty-three @entity1 with chronic @entity7623 (17 @entity6 and 16 idiopathic) received continuous high-frequency/low-energy gastric electrical stimulation via electrodes in the muscle wall of the antrum connected to a neurostimulator in an abdominal wall pocket. After implantation, @entity1 were randomized in a double-blind crossover design to stimulation ON or OFF for 1-month periods. The blind was then broken, and all @entity1 were programmed to stimulation ON and evaluated at 6 and 12 months. Outcome measures were @entity391 frequency, preference for ON or OFF, upper gastrointestinal tract symptoms, quality of life, gastric emptying, and adverse events. RESULTS: In the double-blind portion of the study, self-reported @entity391 frequency was significantly reduced in the ON vs. OFF period (P < 0.05) and this symptomatic improvement was consistent with the significant @entity1 preference (P < 0.05) for the ON vs. OFF period determined before breaking the blind. In the unblinded portion of the study, @entity391 frequency decreased significantly (P < 0.05) at 6 and 12 months. Scores for symptom severity and quality of life significantly improved (P < 0.05) at 6 and 12 months, whereas gastric emptying was only modestly accelerated. Five @entity1 had their gastric electrical stimulation system explanted or revised because of @entity281 . CONCLUSIONS: High-frequency/low-energy gastric electrical stimulation significantly decreased @entity391 frequency and @entity344 and improved quality of life in @entity1 with severe @entity7623 .

title: Gastric electrical stimulation for medically refractory XXXX .

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection or other complications']

entities_list: @entity7623 :: ('MESH:D018589', 'Disease') :: ['gastroparesis', 'symptomatic gastroparesis']

answer: @entity7623 :: (MESH:D018589,Disease) :: ['gastroparesis']


abstract: @entity73 perception is believed to be associated with @entity146 . @entity161 patients with antisocial features are more impaired in @entity2652 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity10420 ( @entity10420 ) using stringent criteria. We recruited 30 @entity1 with dual diagnoses of @entity10420 and @entity161 , 30 @entity1 with @entity161 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity2652 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity2652 , and control for the effect of other @entity149 on @entity2652 . Correlational analyses were conducted to examine the association between @entity2652 and @entity146 . @entity1 with dual diagnoses performed worst in @entity2652 among the three groups. The group differences in @entity2652 remained significant, even after other @entity149 were controlled for. Severity of @entity146 was correlated with impairment in perceiving negative-valenced @entity2652 in @entity1 with dual diagnoses. Our findings support the presence of @entity73 and its association with @entity146 in @entity161 @entity1 with comorbid @entity10420 .

title: @entity73 in XXXX @entity1 with comorbid @entity10420 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients']

entities_list: @entity10420 :: ('MESH:D000987', 'Disease') :: ['antisocial personality disorder', 'ASPD']

entities_list: @entity2652 :: ('MESH:D005148', 'Disease') :: ['facial emotion perception', 'facial emotions']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['facial emotion perception impairment', 'Impairment in facial emotion']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive impairments', 'neurocognitive dysfunctions']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: @entity73 perception is believed to be associated with @entity146 . @entity161 patients with antisocial features are more impaired in @entity2652 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity10420 ( @entity10420 ) using stringent criteria. We recruited 30 @entity1 with dual diagnoses of @entity10420 and @entity161 , 30 @entity1 with @entity161 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity2652 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity2652 , and control for the effect of other @entity149 on @entity2652 . Correlational analyses were conducted to examine the association between @entity2652 and @entity146 . @entity1 with dual diagnoses performed worst in @entity2652 among the three groups. The group differences in @entity2652 remained significant, even after other @entity149 were controlled for. Severity of @entity146 was correlated with impairment in perceiving negative-valenced @entity2652 in @entity1 with dual diagnoses. Our findings support the presence of @entity73 and its association with @entity146 in @entity161 @entity1 with comorbid @entity10420 .

title: @entity73 in @entity161 @entity1 with comorbid XXXX .

answer: @entity10420 :: (MESH:D000987,Disease) :: ['antisocial personality disorder']


abstract: @entity73 perception is believed to be associated with @entity146 . @entity161 patients with antisocial features are more impaired in @entity2652 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity10420 ( @entity10420 ) using stringent criteria. We recruited 30 @entity1 with dual diagnoses of @entity10420 and @entity161 , 30 @entity1 with @entity161 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity2652 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity2652 , and control for the effect of other @entity149 on @entity2652 . Correlational analyses were conducted to examine the association between @entity2652 and @entity146 . @entity1 with dual diagnoses performed worst in @entity2652 among the three groups. The group differences in @entity2652 remained significant, even after other @entity149 were controlled for. Severity of @entity146 was correlated with impairment in perceiving negative-valenced @entity2652 in @entity1 with dual diagnoses. Our findings support the presence of @entity73 and its association with @entity146 in @entity161 @entity1 with comorbid @entity10420 .

title: XXXX in @entity161 @entity1 with comorbid @entity10420 .

answer: @entity73 :: (MESH:D003072,Disease) :: ['Facial emotion perception impairments']


abstract: @entity73 perception is believed to be associated with @entity146 . @entity161 patients with antisocial features are more impaired in @entity2652 than their counterparts without these features. However, previous studies did not define the comorbidity of @entity10420 ( @entity10420 ) using stringent criteria. We recruited 30 @entity1 with dual diagnoses of @entity10420 and @entity161 , 30 @entity1 with @entity161 and 30 controls. We employed the Facial Emotional Recognition paradigm to measure @entity2652 , and administered a battery of neurocognitive tests. The Life History of Aggression scale was used. ANOVAs and ANCOVAs were conducted to examine group differences in @entity2652 , and control for the effect of other @entity149 on @entity2652 . Correlational analyses were conducted to examine the association between @entity2652 and @entity146 . @entity1 with dual diagnoses performed worst in @entity2652 among the three groups. The group differences in @entity2652 remained significant, even after other @entity149 were controlled for. Severity of @entity146 was correlated with impairment in perceiving negative-valenced @entity2652 in @entity1 with dual diagnoses. Our findings support the presence of @entity73 and its association with @entity146 in @entity161 @entity1 with comorbid @entity10420 .

title: @entity73 in @entity161 XXXX with comorbid @entity10420 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity3215 ( @entity3215 ) are environmental pollutants that, because of their persistence and biomagnification, raise concerns about the health consequences of long-term exposure. @entity5241 mixtures induce @entity157 in rodents, but the mechanism of their promoting activity is not clear. Previous studies have shown that oxidative stress occurs after @entity5241 administration, with the induction of lipid peroxidation and oxidative DNA damage, which may contribute to their promoting activity. In this study, we examined whether the oxidative stress-sensitive transcription factors NF-kappaB or @entity19505 were activated by @entity3215 in the liver. Male @entity35 were injected i.p. with @entity4336 oil, @entity12053 ( @entity12053 , 30, 150, or 300 micromol/kg), @entity28168 ( @entity28168 , 30, 150, or 300 micromol/kg), or both @entity3215 (each 30 or 150 micromol/kg). @entity35 were euthanized 2, 6, or 24 h, or 2, 6, and 10 d after the @entity5241 injection. Electrophoretic mobility shift assays (EMSAs) were performed to determine NF-kappaB and @entity19505 DNA binding activities. The highest NF-kappaB DNA binding activity was observed in @entity35 receiving higher doses of @entity12053 (150 and 300 micromol/kg), with peak activation occurring 2 d after injection. @entity19505 activation was not detected at any timepoint. Hepatocyte proliferation, as measured by the labeling index, was increased only in groups receiving the highest dose of @entity12053 or the combination of two @entity3215 (150 micromol/kg each) at day 2, and not by any other @entity5241 treatment at any timepoint. These results show that @entity12053 , but not @entity28168 , can induce hepatocyte proliferation and hepatic NF-kappaB activation after a single dose.

title: Effect of a single dose of @entity3215 on hepatic cell proliferation and the DNA binding activity of NF-kappaB and XXXX in @entity35 .

entities_list: @entity3215 :: ('MESH:D011078', 'Chemical') :: ['PCBs', 'Polychlorinated biphenyls']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats', 'Rats', 'rats']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinomas']

answer: @entity19505 :: (24516(Tax:10116),Gene) :: ['AP-1']


abstract: @entity3215 ( @entity3215 ) are environmental pollutants that, because of their persistence and biomagnification, raise concerns about the health consequences of long-term exposure. @entity5241 mixtures induce @entity157 in rodents, but the mechanism of their promoting activity is not clear. Previous studies have shown that oxidative stress occurs after @entity5241 administration, with the induction of lipid peroxidation and oxidative DNA damage, which may contribute to their promoting activity. In this study, we examined whether the oxidative stress-sensitive transcription factors NF-kappaB or @entity19505 were activated by @entity3215 in the liver. Male @entity35 were injected i.p. with @entity4336 oil, @entity12053 ( @entity12053 , 30, 150, or 300 micromol/kg), @entity28168 ( @entity28168 , 30, 150, or 300 micromol/kg), or both @entity3215 (each 30 or 150 micromol/kg). @entity35 were euthanized 2, 6, or 24 h, or 2, 6, and 10 d after the @entity5241 injection. Electrophoretic mobility shift assays (EMSAs) were performed to determine NF-kappaB and @entity19505 DNA binding activities. The highest NF-kappaB DNA binding activity was observed in @entity35 receiving higher doses of @entity12053 (150 and 300 micromol/kg), with peak activation occurring 2 d after injection. @entity19505 activation was not detected at any timepoint. Hepatocyte proliferation, as measured by the labeling index, was increased only in groups receiving the highest dose of @entity12053 or the combination of two @entity3215 (150 micromol/kg each) at day 2, and not by any other @entity5241 treatment at any timepoint. These results show that @entity12053 , but not @entity28168 , can induce hepatocyte proliferation and hepatic NF-kappaB activation after a single dose.

title: Effect of a single dose of XXXX on hepatic cell proliferation and the DNA binding activity of NF-kappaB and @entity19505 in @entity35 .

answer: @entity3215 :: (MESH:D011078,Chemical) :: ['polychlorinated biphenyls']


abstract: @entity3215 ( @entity3215 ) are environmental pollutants that, because of their persistence and biomagnification, raise concerns about the health consequences of long-term exposure. @entity5241 mixtures induce @entity157 in rodents, but the mechanism of their promoting activity is not clear. Previous studies have shown that oxidative stress occurs after @entity5241 administration, with the induction of lipid peroxidation and oxidative DNA damage, which may contribute to their promoting activity. In this study, we examined whether the oxidative stress-sensitive transcription factors NF-kappaB or @entity19505 were activated by @entity3215 in the liver. Male @entity35 were injected i.p. with @entity4336 oil, @entity12053 ( @entity12053 , 30, 150, or 300 micromol/kg), @entity28168 ( @entity28168 , 30, 150, or 300 micromol/kg), or both @entity3215 (each 30 or 150 micromol/kg). @entity35 were euthanized 2, 6, or 24 h, or 2, 6, and 10 d after the @entity5241 injection. Electrophoretic mobility shift assays (EMSAs) were performed to determine NF-kappaB and @entity19505 DNA binding activities. The highest NF-kappaB DNA binding activity was observed in @entity35 receiving higher doses of @entity12053 (150 and 300 micromol/kg), with peak activation occurring 2 d after injection. @entity19505 activation was not detected at any timepoint. Hepatocyte proliferation, as measured by the labeling index, was increased only in groups receiving the highest dose of @entity12053 or the combination of two @entity3215 (150 micromol/kg each) at day 2, and not by any other @entity5241 treatment at any timepoint. These results show that @entity12053 , but not @entity28168 , can induce hepatocyte proliferation and hepatic NF-kappaB activation after a single dose.

title: Effect of a single dose of @entity3215 on hepatic cell proliferation and the DNA binding activity of NF-kappaB and @entity19505 in XXXX .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: Close association between @entity955 ( @entity955 ) and @entity3876 ( @entity3876 ) has been demonstrated by several studies. Important gender differences exist in @entity955 @entity1 including a higher plasma @entity3876 level in @entity1 . Therefore, it is imperative to evaluate the relationship between @entity955 and @entity3876 separately in @entity1 and @entity1 . OBJECTIVE: This study examined possible gender-specific role of @entity3876 in predicting procedure outcome in @entity955 @entity1 undergoing catheter ablation. METHOD: The study population included 568 consecutive @entity1 (age 62    10, male 73%, paroxysmal 25%, persistent 38%, and long-standing persistent @entity955 37%) undergoing @entity955 ablation, who had structurally normal heart and left ventricular ejection fraction >= 45%. Baseline @entity3876 was measured in all. @entity1 were grouped into "normal" and "high" @entity3876 based on gender-specific cut-off values (<50 and >= 50 pg/mL in males, <100 and >=  100 pg/mL in females). RESULT: Baseline @entity3876 was significantly higher among @entity1 than @entity1 (126    112 versus 87    99, P = 0.009). At 12    6 month follow-up, 304 of 414 (73%) males and 98 of 154 (64%) females were @entity955 / @entity591 -free off antiarrhythmic drugs (log-rank P = 0.018). In multivariable analysis, @entity3876 remained an independent predictor of @entity955 recurrence ( @entity3876 >=  50: hazard ratio [HR] 2.54, P = 0.006) in males. No such association was observed among females ( @entity3876 >=  100: HR 0.79, 95% CI 0.43-1.42; P = 0.426). CONCLUSION: Baseline @entity3876 was found to be an independent predictor of @entity955 recurrence in male @entity1 undergoing ablation. This correlation between @entity3876 and @entity955 recurrence was not observed in females. Thus, @entity3876 plays a gender-specific prognostic role in @entity955 .

title: Baseline B-type natriuretic peptide: a gender-specific predictor of procedure-outcome in XXXX @entity1 undergoing catheter ablation.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['atrial tachycardia']

entities_list: @entity3876 :: ('4879', 'Gene') :: ['BNP', 'brain natriuretic peptide']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: BACKGROUND: Close association between @entity955 ( @entity955 ) and @entity3876 ( @entity3876 ) has been demonstrated by several studies. Important gender differences exist in @entity955 @entity1 including a higher plasma @entity3876 level in @entity1 . Therefore, it is imperative to evaluate the relationship between @entity955 and @entity3876 separately in @entity1 and @entity1 . OBJECTIVE: This study examined possible gender-specific role of @entity3876 in predicting procedure outcome in @entity955 @entity1 undergoing catheter ablation. METHOD: The study population included 568 consecutive @entity1 (age 62    10, male 73%, paroxysmal 25%, persistent 38%, and long-standing persistent @entity955 37%) undergoing @entity955 ablation, who had structurally normal heart and left ventricular ejection fraction >= 45%. Baseline @entity3876 was measured in all. @entity1 were grouped into "normal" and "high" @entity3876 based on gender-specific cut-off values (<50 and >= 50 pg/mL in males, <100 and >=  100 pg/mL in females). RESULT: Baseline @entity3876 was significantly higher among @entity1 than @entity1 (126    112 versus 87    99, P = 0.009). At 12    6 month follow-up, 304 of 414 (73%) males and 98 of 154 (64%) females were @entity955 / @entity591 -free off antiarrhythmic drugs (log-rank P = 0.018). In multivariable analysis, @entity3876 remained an independent predictor of @entity955 recurrence ( @entity3876 >=  50: hazard ratio [HR] 2.54, P = 0.006) in males. No such association was observed among females ( @entity3876 >=  100: HR 0.79, 95% CI 0.43-1.42; P = 0.426). CONCLUSION: Baseline @entity3876 was found to be an independent predictor of @entity955 recurrence in male @entity1 undergoing ablation. This correlation between @entity3876 and @entity955 recurrence was not observed in females. Thus, @entity3876 plays a gender-specific prognostic role in @entity955 .

title: Baseline B-type natriuretic peptide: a gender-specific predictor of procedure-outcome in @entity955 XXXX undergoing catheter ablation.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Approximately 30% of @entity1 undergoing @entity358 ( @entity358 ) for @entity955 ( @entity955 ) have clinical recurrence of @entity955 , and a great majority of these @entity1 have recovery of vein conduction. @entity859 can be associated with acute recovery of conduction to the pulmonary veins immediately after isolation. However, it is not known whether this is prognostic for permanent recovery of conduction or recurrence of @entity955 . METHODS: @entity1 with paroxysmal @entity955 underwent @entity358 , with administration of @entity859 after electrical isolation. Those with transient conduction recovery (TCR+) underwent no further ablation and were compared to those without (TCR-) for clinical @entity955 recurrence and conduction recovery at second procedure. RESULTS: Seventy-two consecutive @entity358 @entity1 were studied (mean age 56.7    9.2, 61 male). Twenty-five (35%) @entity1 had transient recovery of conduction with @entity859 . After 1 year, 18 @entity1 (25%) had symptomatic recurrence of @entity955 . In this group of 18 @entity1 , 6 were TCR+ at initial ablation (sensitivity 33%, NPV = 74%). In the remaining group of 54 @entity1 free from @entity955 recurrence, 35 @entity1 (65%) were TCR- at initial ablation (specificity 65%, @entity2286 = 24%). All 18 @entity1 with recurrent @entity955 underwent repeat procedure and had at least 1 pulmonary vein with recurrent conduction. The initial @entity859 test correctly predicted 13 out of 36 (36%) veins, with positive predictive value 90% and negative predictive value 15%. CONCLUSIONS: @entity859 testing for TCR does not appear to predict recurrence of clinical @entity955 . TCR- veins remain susceptible to conduction recovery, as determined at the follow-up procedure.

title: Does @entity859 response predict clinical recurrence of @entity955 after XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine', 'adenosine']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['PVI', 'pulmonary vein isolation']

answer: @entity358 :: (MESH:D008171,Disease) :: ['pulmonary vein isolation']


abstract: BACKGROUND: Approximately 30% of @entity1 undergoing @entity358 ( @entity358 ) for @entity955 ( @entity955 ) have clinical recurrence of @entity955 , and a great majority of these @entity1 have recovery of vein conduction. @entity859 can be associated with acute recovery of conduction to the pulmonary veins immediately after isolation. However, it is not known whether this is prognostic for permanent recovery of conduction or recurrence of @entity955 . METHODS: @entity1 with paroxysmal @entity955 underwent @entity358 , with administration of @entity859 after electrical isolation. Those with transient conduction recovery (TCR+) underwent no further ablation and were compared to those without (TCR-) for clinical @entity955 recurrence and conduction recovery at second procedure. RESULTS: Seventy-two consecutive @entity358 @entity1 were studied (mean age 56.7    9.2, 61 male). Twenty-five (35%) @entity1 had transient recovery of conduction with @entity859 . After 1 year, 18 @entity1 (25%) had symptomatic recurrence of @entity955 . In this group of 18 @entity1 , 6 were TCR+ at initial ablation (sensitivity 33%, NPV = 74%). In the remaining group of 54 @entity1 free from @entity955 recurrence, 35 @entity1 (65%) were TCR- at initial ablation (specificity 65%, @entity2286 = 24%). All 18 @entity1 with recurrent @entity955 underwent repeat procedure and had at least 1 pulmonary vein with recurrent conduction. The initial @entity859 test correctly predicted 13 out of 36 (36%) veins, with positive predictive value 90% and negative predictive value 15%. CONCLUSIONS: @entity859 testing for TCR does not appear to predict recurrence of clinical @entity955 . TCR- veins remain susceptible to conduction recovery, as determined at the follow-up procedure.

title: Does @entity859 response predict clinical recurrence of XXXX after @entity358 ?

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']