abstract: BACKGROUND: Energy drinks are popular mixers with @entity285 . While energy drinks contain many ingredients, @entity5834 is an important pharmacologically active component and is generally present in larger amounts than in other caffeinated beverages. In these studies, we investigated the hypothesis that @entity5834 would influence the effects of @entity285 ( @entity1068 [ @entity167 ]) on conditioned taste aversion (CTA), @entity2055 , and locomotor activity (LA) after repeated exposure. METHODS: Four groups of @entity19 were exposed by oral gavage twice daily to vehicle, @entity167 (4  g/kg), @entity5834 (15  mg/kg), or the @entity167 / @entity5834 combination. CTA to @entity8021 and @entity2055 in the parallel rod task was evaluated after 8 or 16 gavages, respectively, using @entity167 (1 to 3  g/kg) or @entity167 / @entity5834 (3  mg/kg  +  2  g/kg) challenges. In addition, LA was evaluated initially and after repeated exposure to oral gavage of these drugs and doses. RESULTS: Repeated oral gavage of @entity167 produced significant locomotor sensitization, with those @entity19 increasing total distance traveled by 2-fold. The locomotor response to @entity5834 , while significantly greater than vehicle gavage, did not change with repeated exposure. On the other hand, repeated gavage of @entity5834 / @entity167 combination produced a substantial increase in total distance traveled after repeated exposure (~4-fold increase). After repeated @entity167 exposure, there was significant tolerance to @entity167 in the CTA and parallel rod tests. However, neither a history of @entity5834 exposure nor including @entity5834 influenced @entity167 -induced CTA. Interestingly, a history of @entity5834 exposure increased the ataxic response to the @entity5834 / @entity167 combination and appeared to reduce the ataxic response to high doses of @entity167 . CONCLUSIONS: The data support the general hypothesis that repeated exposure to @entity5834 influences the response to @entity167 . Together with previously published work, these data indicate that @entity5834 influences some @entity167 -related behaviors, notably locomotion and @entity2055 , but appears not to influence the expression of conditioned behaviors.

title: Sensitization and Tolerance Following Repeated Exposure to @entity5834 and @entity285 in XXXX .

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: OBJECTIVE: The objective of our study was to assess the frequency, cause, and time course of @entity1282 after @entity11375 ( @entity11375 ). MATERIALS AND METHODS: A review of the surgical database revealed that 1789 @entity1 underwent @entity11375 procedures during the 8-year study period. A radiologic database review indicated that 80 of the 1789 @entity1 underwent radiologic evaluation for the assessment of @entity1282 after @entity11375 . Three @entity1 were excluded from the study because they had a history of @entity1282 before @entity11375 , and three additional @entity1 were excluded because they had more recently undergone Nissen fundoplication, intubation, and radiation therapy, respectively. @entity1282 ( @entity1282 ) studies and esophagrams of the 74 remaining @entity1 were collected and analyzed to determine the cause of @entity1282 and time course of @entity1282 onset after surgery. RESULTS: @entity1282 was evaluated radiologically in 74 of the 1789 @entity11375 @entity1 (4.1%) using video @entity1282 studies (n = 66) and esophagography (n = 26). @entity1 underwent radiologic evaluation from 1 to 1150 days after surgery (mean, 120 days after surgery); 76% of the @entity1 presented more than 2 weeks after surgery. The location of the @entity11375 in the study group was the upper, mid, and lower cervical spine in 5.4% (n = 4), 55.4% (n = 41), and 39.2% (n = 29) of @entity1 , respectively. Soft-tissue swelling with displacement of the pharynx or esophagus was identified in 91% of @entity1 (n = 67). More serious complications of @entity11375 that resulted in @entity1282 included surgical hardware displacement or bone graft displacement (n = 18), esophageal perforation (n = 3), and a retropharyngeal abscess (n = 3). Pharyngeal functional abnormalities were detected in 50 @entity1 , with penetration, aspiration, or both seen in 32. CONCLUSION: @entity1282 is an underrecognized but significant complication of @entity11375 . After @entity11375 , 4.1% of @entity1 presented for radiologic evaluation of @entity1282 . Although @entity11375 procedures are most frequently performed in the lower cervical spine, @entity1282 is a more common clinical problem after @entity11375 in the mid cervical spine. Radiologic examinations should be specifically tailored to evaluate @entity11375 @entity1 .

title: XXXX Secondary to Anterior Cervical Fusion: Radiologic Evaluation and Findings in 74 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity11375 :: ('MESH:D007714', 'Disease') :: ['anterior cervical fusion', 'ACF']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['Modified barium swallow', 'MBS', 'Dysphagia', 'dysphagia']

answer: @entity1282 :: (MESH:D003680,Disease) :: ['Dysphagia']


abstract: OBJECTIVE: The objective of our study was to assess the frequency, cause, and time course of @entity1282 after @entity11375 ( @entity11375 ). MATERIALS AND METHODS: A review of the surgical database revealed that 1789 @entity1 underwent @entity11375 procedures during the 8-year study period. A radiologic database review indicated that 80 of the 1789 @entity1 underwent radiologic evaluation for the assessment of @entity1282 after @entity11375 . Three @entity1 were excluded from the study because they had a history of @entity1282 before @entity11375 , and three additional @entity1 were excluded because they had more recently undergone Nissen fundoplication, intubation, and radiation therapy, respectively. @entity1282 ( @entity1282 ) studies and esophagrams of the 74 remaining @entity1 were collected and analyzed to determine the cause of @entity1282 and time course of @entity1282 onset after surgery. RESULTS: @entity1282 was evaluated radiologically in 74 of the 1789 @entity11375 @entity1 (4.1%) using video @entity1282 studies (n = 66) and esophagography (n = 26). @entity1 underwent radiologic evaluation from 1 to 1150 days after surgery (mean, 120 days after surgery); 76% of the @entity1 presented more than 2 weeks after surgery. The location of the @entity11375 in the study group was the upper, mid, and lower cervical spine in 5.4% (n = 4), 55.4% (n = 41), and 39.2% (n = 29) of @entity1 , respectively. Soft-tissue swelling with displacement of the pharynx or esophagus was identified in 91% of @entity1 (n = 67). More serious complications of @entity11375 that resulted in @entity1282 included surgical hardware displacement or bone graft displacement (n = 18), esophageal perforation (n = 3), and a retropharyngeal abscess (n = 3). Pharyngeal functional abnormalities were detected in 50 @entity1 , with penetration, aspiration, or both seen in 32. CONCLUSION: @entity1282 is an underrecognized but significant complication of @entity11375 . After @entity11375 , 4.1% of @entity1 presented for radiologic evaluation of @entity1282 . Although @entity11375 procedures are most frequently performed in the lower cervical spine, @entity1282 is a more common clinical problem after @entity11375 in the mid cervical spine. Radiologic examinations should be specifically tailored to evaluate @entity11375 @entity1 .

title: @entity1282 Secondary to Anterior Cervical Fusion: Radiologic Evaluation and Findings in 74 XXXX .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Five cases of @entity3439 from @entity397 (SDH-AR) are described and other 39 reported cases are reviewed. The average age of the @entity1 is 59 and male to female ratio is 2:1. Fifty two percent of the @entity1 have history of recent @entity542 most of which are trivial. A very few @entity1 have @entity909 . Approximately half of the @entity1 with history of @entity542 have long lucid interval (average of 7 days). Those @entity1 without history of @entity542 have spontaneous onset of the symptoms and some of the have acute onset of @entity10 and @entity909 , simulating @entity64 . Natural history of the SDH-AR is progressing deterioration of the symptoms, resulting in @entity772 and @entity204 . Skull fracture is seldom demonstrated in the @entity1 with SDH-AR. Angiography shows and extracerebral avascular mass over the cerebral convexity with marked midline shift. In 3 cases including our 2 cases, extravasation of the contrast medium from the cortical artery is observed and this is a useful finding for making diagnosis of this disease. Computerized tomography reveals high density extracerebral mass with remarkable mass effect. Craniotomy discloses subdural clot and spurting @entity397 from a branch of the cortical artery around the Sylvian fissure. In some cases, @entity510 is observed but in none of the cases, cerebral contusion or laceration is present. It is presumed that the mechanism of the @entity397 is gliding movement of the brain within the skull upon injury, tearing an arterial twig with dural attachment. @entity101 , @entity4288 and @entity1010 may be important contributing factors to this mechanism. @entity2849 caused by closed @entity542 is also associated with this mechanism and may explain delayed sudden onset of the symptoms in some @entity1 with SDH-AR.

title: [Subdural hematoma from @entity397 -mechanism of XXXX in minor @entity542 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3439 :: ('MESH:D006408', 'Disease') :: ['subdural hematoma']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['cerebrovascular accident']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head trauma', 'head injuries', 'head injury']

entities_list: @entity909 :: ('MESH:D014474', 'Disease') :: ['initial loss of consciousness', 'loss of consciousness']

entities_list: @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['arterial rupture']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['Pseudoaneurysm of the cortical artery']

entities_list: @entity4288 :: ('MESH:D001161', 'Disease') :: ['arteriosclerosis']

answer: @entity397 :: (MESH:D012421,Disease) :: ['arterial rupture']


abstract: Five cases of @entity3439 from @entity397 (SDH-AR) are described and other 39 reported cases are reviewed. The average age of the @entity1 is 59 and male to female ratio is 2:1. Fifty two percent of the @entity1 have history of recent @entity542 most of which are trivial. A very few @entity1 have @entity909 . Approximately half of the @entity1 with history of @entity542 have long lucid interval (average of 7 days). Those @entity1 without history of @entity542 have spontaneous onset of the symptoms and some of the have acute onset of @entity10 and @entity909 , simulating @entity64 . Natural history of the SDH-AR is progressing deterioration of the symptoms, resulting in @entity772 and @entity204 . Skull fracture is seldom demonstrated in the @entity1 with SDH-AR. Angiography shows and extracerebral avascular mass over the cerebral convexity with marked midline shift. In 3 cases including our 2 cases, extravasation of the contrast medium from the cortical artery is observed and this is a useful finding for making diagnosis of this disease. Computerized tomography reveals high density extracerebral mass with remarkable mass effect. Craniotomy discloses subdural clot and spurting @entity397 from a branch of the cortical artery around the Sylvian fissure. In some cases, @entity510 is observed but in none of the cases, cerebral contusion or laceration is present. It is presumed that the mechanism of the @entity397 is gliding movement of the brain within the skull upon injury, tearing an arterial twig with dural attachment. @entity101 , @entity4288 and @entity1010 may be important contributing factors to this mechanism. @entity2849 caused by closed @entity542 is also associated with this mechanism and may explain delayed sudden onset of the symptoms in some @entity1 with SDH-AR.

title: [Subdural hematoma from XXXX -mechanism of @entity397 in minor @entity542 ].

answer: @entity397 :: (MESH:D012421,Disease) :: ['arterial rupture']


abstract: Five cases of @entity3439 from @entity397 (SDH-AR) are described and other 39 reported cases are reviewed. The average age of the @entity1 is 59 and male to female ratio is 2:1. Fifty two percent of the @entity1 have history of recent @entity542 most of which are trivial. A very few @entity1 have @entity909 . Approximately half of the @entity1 with history of @entity542 have long lucid interval (average of 7 days). Those @entity1 without history of @entity542 have spontaneous onset of the symptoms and some of the have acute onset of @entity10 and @entity909 , simulating @entity64 . Natural history of the SDH-AR is progressing deterioration of the symptoms, resulting in @entity772 and @entity204 . Skull fracture is seldom demonstrated in the @entity1 with SDH-AR. Angiography shows and extracerebral avascular mass over the cerebral convexity with marked midline shift. In 3 cases including our 2 cases, extravasation of the contrast medium from the cortical artery is observed and this is a useful finding for making diagnosis of this disease. Computerized tomography reveals high density extracerebral mass with remarkable mass effect. Craniotomy discloses subdural clot and spurting @entity397 from a branch of the cortical artery around the Sylvian fissure. In some cases, @entity510 is observed but in none of the cases, cerebral contusion or laceration is present. It is presumed that the mechanism of the @entity397 is gliding movement of the brain within the skull upon injury, tearing an arterial twig with dural attachment. @entity101 , @entity4288 and @entity1010 may be important contributing factors to this mechanism. @entity2849 caused by closed @entity542 is also associated with this mechanism and may explain delayed sudden onset of the symptoms in some @entity1 with SDH-AR.

title: [Subdural hematoma from @entity397 -mechanism of @entity397 in minor XXXX ].

answer: @entity542 :: (MESH:D006259,Disease) :: ['head injury']


abstract: The Lund Clinic serves a population of 1.46 million inhabitants. During the calendar year 1981, 72 @entity1 presented with a ruptured supratentorial @entity439 , diagnosed either at angiography or at autopsy. Upon admission, 60% of the @entity1 were in good condition and 40% were in poor condition. Eighty-three per cent were admitted within 72 hours after the @entity510 ( @entity510 ). In the total series, 50% made a good recovery; the overall management morbidity was 19% and the management mortality was 31%. Thirty-one @entity1 in Grades I-III underwent early operation (43% of the total series), with a favorable outcome in 74% and 7% mortality. Of the 35 @entity1 who were admitted early and in good condition, 71% made a good recovery, and the management mortality was 9%. These figures may be compared to the 51% favorable outcome and 27% mortality reported from the Cooperative @entity439 Study with late operation. In the early operation cases, the incidence of significant arterial narrowing at postoperative angiography performed on Day 9 +/- 2 after @entity510 was 30% and the incidence of permanent @entity51 of delayed onset was 10%. Two of the early operation @entity1 developed permanent symptomatic @entity1276 .

title: Early management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['SAH', 'subarachnoid hemorrhage']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['Aneurysm', 'aneurysm']

answer: @entity510 :: (MESH:D013345,Disease) :: ['aneurysmal subarachnoid hemorrhage']


abstract: UNASSIGNED: Inhalation of @entity842 (NO) produces selective pulmonary vasodilation and is an effective therapy for treating @entity120 in adults and @entity1 . In the United States, the average cost of 5 days of inhaled NO for persistent @entity120 of the newborn is about  14,000. NO therapy involves gas cylinders and distribution, a complex delivery device, gas monitoring and calibration equipment, and a trained respiratory therapy staff. The objective of this study was to develop a lightweight, portable device to serve as a simple and economical method of producing pure NO from air for bedside or portable use. Two NO generators were designed and tested: an offline NO generator and an inline NO generator placed directly within the inspiratory line. Both generators use pulsed electrical discharges to produce therapeutic range NO (5 to 80 parts per million) at gas flow rates of 0.5 to 5 liters/min. NO was produced from air, as well as gas mixtures containing up to 90% @entity3612 and 10% N2. Potentially toxic gases produced in the plasma, including @entity7459 ( @entity6836 ) and @entity1787 (O3), were removed using a @entity6086 scavenger. An @entity3201 spark electrode produced the lowest ratio of @entity6836 /NO. In @entity742 with @entity120 , breathing electrically generated NO produced pulmonary vasodilation and reduced pulmonary arterial pressure and pulmonary vascular resistance index. In conclusion, electrical plasma NO generation produces therapeutic levels of NO from air. After scavenging to remove @entity6836 and O3 and filtration to remove particles, electrically produced NO can provide safe and effective treatment of @entity120 .

title: Producing XXXX by pulsed electrical discharge in air for portable inhalation therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity7459 :: ('MESH:D009585', 'Chemical') :: ['nitrogen dioxide']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'acute pulmonary hypertension']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity6086 :: ('MESH:D002126', 'Chemical') :: ['calcium hydroxide']

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: BACKGROUND: @entity320 is a very rare paediatric @entity5 . This study was performed in order to understand clinical features and prognosis of @entity320 in @entity1 and adolescents. METHODS: 443 @entity1    18years of age with @entity320 were prospectively registered with the German Central @entity320 Registry between 1983 and 2011. Cases were collected from 58 participating centres. 276 paediatric cases with a follow-up >3months were evaluated for survival probabilities and prognostic factors by Kaplan-Meier method. RESULTS: Age of diagnosis ranged from 3months to 18years (median age 16years). The male to female ratio was 0.8 (202 male, 240 female). Most @entity320 were located at the trunk (n=195) and the lower extremity (n=114). @entity1 with >3months of follow-up (median 55months) showed an @entity1349 ( @entity1349 ) of 94.8% in 5years. Survival according to @entity5 stage was 98.5% for stage I (n=190), 91.1% for stage II (n=39) and 53.0% for stage III/IV @entity5 (n=11). Worse outcome was seen in @entity1 with @entity320 ( @entity1349 77.9%, n=42) compared to superficial spread histotype ( @entity1349 100%, n=138) or other histotype ( @entity1349 96.9%, n=88) (p<0.0001), in case of thicker @entity5 (Clark level IV or V, @entity1349 87.1%, n=84) compared to thinner @entity5 (Clark level I, II, III, @entity1349 99.1%, n=164) (p=0.0008) and in case of @entity1066 ( @entity1349 65.6%, n=17) compared to no @entity1066 ( @entity1349 99.2%, n=182). CONCLUSION: @entity1 and @entity5 characteristics in paediatric @entity320 @entity1 show no evident differences to adult @entity320 cases. The same clinical approach as in adults should be used.

title: 443 paediatric cases of @entity320 registered with the German Central XXXX Registry between 1983 and 2011.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'Patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'Malignant melanoma', 'Malignant Melanoma', 'malignant melanoma', 'nodular melanoma']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity320 :: (MESH:D008545,Disease) :: ['Malignant Melanoma']


abstract: BACKGROUND: @entity320 is a very rare paediatric @entity5 . This study was performed in order to understand clinical features and prognosis of @entity320 in @entity1 and adolescents. METHODS: 443 @entity1    18years of age with @entity320 were prospectively registered with the German Central @entity320 Registry between 1983 and 2011. Cases were collected from 58 participating centres. 276 paediatric cases with a follow-up >3months were evaluated for survival probabilities and prognostic factors by Kaplan-Meier method. RESULTS: Age of diagnosis ranged from 3months to 18years (median age 16years). The male to female ratio was 0.8 (202 male, 240 female). Most @entity320 were located at the trunk (n=195) and the lower extremity (n=114). @entity1 with >3months of follow-up (median 55months) showed an @entity1349 ( @entity1349 ) of 94.8% in 5years. Survival according to @entity5 stage was 98.5% for stage I (n=190), 91.1% for stage II (n=39) and 53.0% for stage III/IV @entity5 (n=11). Worse outcome was seen in @entity1 with @entity320 ( @entity1349 77.9%, n=42) compared to superficial spread histotype ( @entity1349 100%, n=138) or other histotype ( @entity1349 96.9%, n=88) (p<0.0001), in case of thicker @entity5 (Clark level IV or V, @entity1349 87.1%, n=84) compared to thinner @entity5 (Clark level I, II, III, @entity1349 99.1%, n=164) (p=0.0008) and in case of @entity1066 ( @entity1349 65.6%, n=17) compared to no @entity1066 ( @entity1349 99.2%, n=182). CONCLUSION: @entity1 and @entity5 characteristics in paediatric @entity320 @entity1 show no evident differences to adult @entity320 cases. The same clinical approach as in adults should be used.

title: 443 paediatric cases of XXXX registered with the German Central @entity320 Registry between 1983 and 2011.

answer: @entity320 :: (MESH:D008545,Disease) :: ['malignant melanoma']


abstract: BACKGROUND: Vagus nerve stimulation (VNS) has been approved for the treatment of refractory partial epi.lepsy in adults and @entity1 over 12 years of age. Later on, its application expanded to include younger @entity1 and other types of @entity302 . We report our experience with this treatment modality for @entity302 in Saudi Arabia. DESIGN AND SETTINGS: Open-label, uncontrolled, retrospective study of @entity1 with @entity302 , who were treated with VNS in a tertiary care hospital from January 2010 to June 2013. @entity1 AND METHODS: Collected data included 26 @entity1 ' demographics, @entity302 characteristics, sei.zure frequency, and treatment history. @entity1 with a follow-up duration of minimum 12 months were included in the analysis. The examined outcome measures were @entity410 reduction rates, @entity734 ( @entity734 ) burden, and impact on @entity1 ' quality of life (QOL). RESULTS: Onset of @entity410 was from birth to 30 years. @entity1 ' ages at VNS implantation ranged from 4 to 38 years (18.9 [8.7] years). @entity302 was classified as focal in 8 @entity1 (30%), multifocal in 9 @entity1 (35%), and generalized in 9 @entity1 (35%). The average number of @entity734 failed before VNS was 4.2 (1.4). Greater than 50% @entity410 reduction was achieved in 50% of @entity1 at 3 months, 67% at 6 months, 73% at 12 months, and 78% at 24 months. There was no significant reduction in @entity734 burden during the same period. Subjective QOL improvement was reported by 72% of @entity1 at 3 months, 83% at 6 months, 78% at 12 months, and 73% at 24 months after VNS. Minor adverse effects were reported in 27% of @entity1 . One @entity1 had the device replaced due to malfunction. CONCLUSION: The experience with VNS in a single center in Saudi Arabia confirms that it is a safe and effec.tive adjunctive therapy for @entity302 in adult and pediatric @entity1 .

title: Vagus nerve stimulation for XXXX : experience from Saudi Arabia.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['AEDs', 'antiepileptic drugs']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['refractory epilepsy', 'epilepsy', 'Epilepsy']

answer: @entity302 :: (MESH:D004827,Disease) :: ['refractory epilepsy']


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity291 @entity1576 (BRD) complex in Holstein pre-weaned dairy @entity291 . Systematic @entity1514 ( @entity1514 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity291 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity291 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity291 ) from North America were studied. All @entity291 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity1514 (cutoff used >= 1cm of @entity358 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity1514 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity1514 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity1514 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the XXXX respiratory scoring chart and ultrasonography for the diagnosis of @entity291 @entity1576 in pre-weaned dairy @entity291 .

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['TUS', 'thoracic ultrasonography']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung consolidation']

entities_list: @entity291 :: ('9913', 'Species') :: ['calf', 'bovine', 'calves']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease']

answer: @entity291 :: (9913,Species) :: ['calf']


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity291 @entity1576 (BRD) complex in Holstein pre-weaned dairy @entity291 . Systematic @entity1514 ( @entity1514 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity291 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity291 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity291 ) from North America were studied. All @entity291 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity1514 (cutoff used >= 1cm of @entity358 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity1514 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity1514 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity1514 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the @entity291 respiratory scoring chart and ultrasonography for the diagnosis of XXXX @entity1576 in pre-weaned dairy @entity291 .

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity291 @entity1576 (BRD) complex in Holstein pre-weaned dairy @entity291 . Systematic @entity1514 ( @entity1514 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity291 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity291 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity291 ) from North America were studied. All @entity291 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity1514 (cutoff used >= 1cm of @entity358 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity1514 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity1514 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity1514 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the @entity291 respiratory scoring chart and ultrasonography for the diagnosis of @entity291 @entity1576 in pre-weaned dairy XXXX .

answer: @entity291 :: (9913,Species) :: ['calves']


abstract: UNASSIGNED: There is currently no gold standard method for the diagnosis of @entity291 @entity1576 (BRD) complex in Holstein pre-weaned dairy @entity291 . Systematic @entity1514 ( @entity1514 ) has been used as a proxy for BRD, but cannot be directly used by producers. The Wisconsin @entity291 respiratory scoring chart (CRSC) is a simpler alternative, but with unknown accuracy. Our objective was to estimate the accuracy of CRSC, while adjusting for the lack of a gold standard. Two cross sectional study populations with a high BRD prevalence (n=106 pre-weaned Holstein @entity291 ) and an average BRD prevalence (n=85 pre-weaned Holstein @entity291 ) from North America were studied. All @entity291 were simultaneously assessed using CRSC (cutoff used >= 5) and @entity1514 (cutoff used >= 1cm of @entity358 ). Bayesian latent class models allowing for conditional dependence were used with informative priors for BRD prevalence and @entity1514 accuracy (sensitivity (Se) and specificity (Sp)) and non-informative priors for CRSC accuracies. Robustness of the model was tested by relaxing priors for prevalence or @entity1514 accuracy. The SeCRSC (95% credible interval (CI)) and SpCRSC were 62.4% (47.9-75.8) and 74.1% (64.9-82.8) respectively. The SeTUS was 79.4% (66.4-90.9) and SpTUS was 93.9% (88.0-97.6). The imperfect accuracy of CRSC and @entity1514 should be taken into account when using those tools to assess BRD status.

title: Bayesian estimation of the accuracy of the @entity291 respiratory scoring chart and ultrasonography for the diagnosis of @entity291 XXXX in pre-weaned dairy @entity291 .

answer: @entity1576 :: (MESH:D012131,Disease) :: ['respiratory disease']


abstract: BACKGROUND CONTEXT: The most common adverse event after a lumbar puncture (LP) is a @entity10 : In anaesthesiology, well studied is the protective effect of atraumatic spinal needles, and they are routinely used. However, this is less well known in diagnostic LP, and neurologists use atraumatic needles in less than 2% of times. PURPOSE: The purpose of this study was to define the impact of needle type, atraumatic (Sprotte [S]) versus traumatic (Quincke [Q]) on postdural puncture @entity10 (PDPH) incidence. STUDY DESIGN: The study is based on a prospective, randomized, and simple-blinded clinical trial. @entity1 SAMPLE: @entity1 older than 14 years were scheduled for a diagnostic or therapeutic LP. OUTCOME MEASURES: The outcome measure included the development of PDPH according to the International @entity10 Association criteria. METHODS: @entity1 fulfilling eligibility criteria were randomly allocated to one of two kinds of spinal needle: atraumatic or S-type or traumatic or Q-type. They were interviewed on days 2 and 7 about the development of PDPH. RESULTS: The incidence of PDPH was 22.43% with Q-type needle and 8.51% with S-type needle, p=.04. The duration of PDPH in @entity1 in the S-type was 1 day or less, compared with a median of 4.14 days in the Q-type (p=.00). In the logistic regression model, the S-type needle together with the age of the @entity1 were the only two statistically significant factors in the development of postlumbar puncture @entity10 (PLPH), both of them being protective. CONCLUSIONS: We found a lower incidence of PDPH with atraumatic needles, and it was statistically significant compared with the traumatic needles. Our study confirms the effectiveness of the atraumatic needles to prevent PDPH.

title: Postdural puncture XXXX : impact of needle type, a randomized trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENT']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'Headache']

answer: @entity10 :: (MESH:D006261,Disease) :: ['headache']


abstract: BACKGROUND AND STUDY AIMS: Endoscopic implantation of a duodenal-jejunal bypass liner (DJBL) is a novel bariatric technique to induce @entity353 and remission of @entity6 . Placement of the DJBL mimics the bypass component of the Roux-en-Y gastric bypass (RYGB) procedure. In this observational study, we evaluated improvement of glycemic control and @entity353 in the course of the treatment (0-24 weeks after DJBL implantation) and analyzed accompanying gut hormone responses. @entity1 AND METHODS: 12 @entity28 individuals with @entity164 2 @entity6 were selected for DJBL implantation. Body weight, fat mass, and fasting plasma levels of @entity413 , insulin, C-peptide, and glycated hemoglobin (HbA1c), were analyzed at 0, 1, 4 and 24 weeks post-implant. Fasting ghrelin, gastric inhibitory peptide (GIP), and glucagon-like peptide ( @entity6757 ) were determined at 0, 1 and 4 weeks post-implant. RESULTS: Besides significant @entity353 , fat mass, fasting insulin, and homeostasis model assessment-estimated insulin resistance (HOMA-IR) index were also significantly decreased after DJBL implantation and a 42% reduction was found in @entity6 medication (P<0.05). The fasting @entity6757 response in the first 4 weeks post-implant was significantly correlated with the fasting insulin and HOMA-IR response. Fasting ghrelin was found to be significantly elevated, in contrast to the decrease in ghrelin that is found after RYGB surgery. CONCLUSIONS: DJBL implantation provoked significant @entity353 , a decrease in fat mass, and an early remission of @entity164 2 @entity6 , comparable to results seen after RYGB surgery. Gut hormone analyses revealed a potential role of fasting @entity6757 in early remission of @entity164 2 @entity6 . Interestingly, the DJBL-induced elevation of ghrelin contradicts the suggested role of reduced ghrelin levels after RYGB in improvement of glycemic control.

title: Duodenal-jejunal bypass liner implantation provokes rapid XXXX and improved glycemic control, accompanied by elevated fasting ghrelin levels.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'type 2 diabetes mellitus']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity353 :: (MESH:D015431,Disease) :: ['weight loss']


abstract: Establishment of @entity8416 infective larvae is blocked to a large degree in the immune @entity35 as compared with the nonimmune host. The rapidity with which this response occurs indicates that most worms are either prevented from penetrating the intestinal epithelium or are rejected immediately after cell entry. It is proposed that interference with larval infectivity is due to alterations in the epithelial cell apical or brush border membrane. Alterations may result from prior @entity281 or may reflect an acute change induced by @entity281 . In either case the establishment of normal populations of larvae in the mucosa is disturbed. Lectin binding capacity of brush border membranes was used to assess possible membrane alterations. This parameter in uninfected (control) @entity35 was compared with that in infected @entity35 , which acquire resistance to subsequent challenge, and in infected @entity35 immediately after a challenge inoculum. Enriched brush border membrane preparations were characterized for their binding of @entity3505 germ agglutinin, which attaches specifically to the @entity1735 , @entity3954 . Maximum specific binding of 125I-labeled @entity3505 germ agglutinin occurred within 20 min. The spontaneous rate of dissociation was negligible for 90 min. Highest specific binding resulted at 24 degrees C, pH 6.0 and with 75 micrograms brush border membrane protein per assay tube. Results suggested the existence of multiple binding sites. 1 mg of membrane protein from uninfected @entity35 and @entity35 immunized by @entity281 maximally bound 9.8 X 10(10) and 4.3 X 10(10) molecules of @entity3505 germ agglutinin, respectively. Binding for the 'immune' brush border membrane, as compared with the 'uninfected' brush border membrane was reduced during the first 3 weeks of @entity281 and remained low for at least 3 months. No further reduction in binding was observed for brush border membrane isolated within minutes after a secondary @entity281 . These results reveal the induction by a @entity281 of changes in brush border membrane structure and the persistence of these changes in the immune host. In view of the rapid turnover time of epithelial tissue the mechanism by which this change is perpetuated speculatively involves immune elements in the lamina propria.

title: Intestinal epithelial membrane changes in @entity35 immune to XXXX .

entities_list: @entity8416 :: ('6334', 'Species') :: ['Trichinella spiralis']

entities_list: @entity3954 :: ('CHEBI:28009', 'Chemical') :: ['N-acetylglucosamine']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['challenge infection', 'infection', 'primary infection']

answer: @entity8416 :: (6334,Species) :: ['Trichinella spiralis']


abstract: Establishment of @entity8416 infective larvae is blocked to a large degree in the immune @entity35 as compared with the nonimmune host. The rapidity with which this response occurs indicates that most worms are either prevented from penetrating the intestinal epithelium or are rejected immediately after cell entry. It is proposed that interference with larval infectivity is due to alterations in the epithelial cell apical or brush border membrane. Alterations may result from prior @entity281 or may reflect an acute change induced by @entity281 . In either case the establishment of normal populations of larvae in the mucosa is disturbed. Lectin binding capacity of brush border membranes was used to assess possible membrane alterations. This parameter in uninfected (control) @entity35 was compared with that in infected @entity35 , which acquire resistance to subsequent challenge, and in infected @entity35 immediately after a challenge inoculum. Enriched brush border membrane preparations were characterized for their binding of @entity3505 germ agglutinin, which attaches specifically to the @entity1735 , @entity3954 . Maximum specific binding of 125I-labeled @entity3505 germ agglutinin occurred within 20 min. The spontaneous rate of dissociation was negligible for 90 min. Highest specific binding resulted at 24 degrees C, pH 6.0 and with 75 micrograms brush border membrane protein per assay tube. Results suggested the existence of multiple binding sites. 1 mg of membrane protein from uninfected @entity35 and @entity35 immunized by @entity281 maximally bound 9.8 X 10(10) and 4.3 X 10(10) molecules of @entity3505 germ agglutinin, respectively. Binding for the 'immune' brush border membrane, as compared with the 'uninfected' brush border membrane was reduced during the first 3 weeks of @entity281 and remained low for at least 3 months. No further reduction in binding was observed for brush border membrane isolated within minutes after a secondary @entity281 . These results reveal the induction by a @entity281 of changes in brush border membrane structure and the persistence of these changes in the immune host. In view of the rapid turnover time of epithelial tissue the mechanism by which this change is perpetuated speculatively involves immune elements in the lamina propria.

title: Intestinal epithelial membrane changes in XXXX immune to @entity8416 .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: PURPOSE: The surgical margin is the main prognostic factor over which the surgeon has control during resection of @entity957 ( @entity957 ). This study examined the association between surgical excision margins of @entity1 with @entity957 and outcomes of disease-free and overall survival. MATERIALS AND METHODS: The authors implemented a retrospective cohort study. The sample was composed of @entity1 with @entity957 having resection as their initial treatment. The predictor variable was the pathologic surgical margin, defined as clear (>5  mm), close (1 to 5  mm), or involved (<1  mm). The outcome variables were disease-free (absence of locoregional recurrence) and overall survival. Data were analyzed using Kaplan-Meier survival curves and @entity797 regression hazard model. RESULTS: The sample was composed of 54 @entity1 with a mean age of 60.5  years (range, 19 to 85  yr) and 26% were @entity1 . The 2- and 5-year overall survival rates were 59 and 50%, respectively. The clear surgical margin group showed higher disease-free survival rates than @entity1 with close and involved margins (5-yr probability, 0.78 vs 0.43 and 0.29; P  = .014) and a trend toward increased overall survival at 2 and 5  years (P  = .093). CONCLUSION: The results suggest that the presence of a close surgical margin (1 to 5  mm) is an adverse risk feature comparable to an involved margin and therefore is associated with decreased disease-free and overall survival. Future studies are needed to replicate these findings before they can be used as a basis for clinical recommendations.

title: How Does the Close Surgical Margin Impact Recurrence and Survival When Treating XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['OSCC', 'oral squamous cell carcinoma']

answer: @entity957 :: (MESH:D002294,Disease) :: ['Oral Squamous Cell Carcinoma']


abstract: KEY MESSAGE: Conditions for the isolation and transfection of @entity2829 nucellus protoplasts were established. We demonstrated its utilization for protein expression, localization, protein-protein interaction, and the investigation of @entity204 -related processes. Plant protoplasts are an important and versatile cell system that is widely used in the analysis of gene characterization and diverse signaling pathways. @entity204 ( @entity204 ) occurs throughout the life of plants from embryogenesis to fertilization. The @entity2829 nucellus undergoes typical @entity204 during development of the embryo sac. The nucellus protoplast shows potential for use in research of @entity204 -related processes. No studies have reported previously the isolation and transfection of nucellus protoplasts. In this study, conditions for the isolation and transfection of @entity2829 nucellus protoplasts were established. The @entity2829 protoplast system can be used for protein expression, localization, and protein-protein interaction. We applied this system to investigate @entity204 -related processes. Quantitative real-time PCR analysis revealed that transient expression of @entity56823 in the @entity2829 nucellus protoplast increases @entity2569 -protease gene transcript level. In addition, b-glucuronidase and luciferase activity assays showed that @entity56823 could enhance the promoter activities of the @entity2569 -protease gene. Thus, we demonstrated the potential of a highly efficient @entity2829 nucellus protoplast system for transient gene expression and investigation of @entity204 -related processes.

title: A highly efficient XXXX nucellus protoplast system for transient gene expression and studying programmed cell death-related processes.

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['PCD', 'Programmed cell death']

answer: @entity2829 :: (4577,Species) :: ['maize']


abstract: @entity9360 is a rare @entity209 leading to systemic changes including early and severe @entity2720 which affects mobility. For unknown reasons, the onset of degenerative changes is delayed to around 30 years of age when both objective and subjective symptoms develop. In order to complement description of the structural changes in @entity9360 with measures of movement function, clinical gait analysis was added to the list of assessments in 2013. The aim of this study was to describe the deviation of gait from normality as a function of age in @entity1 with @entity9360 . Three-dimensional movement of reflective markers attached to joints were captured during walking in 39 @entity1 and 10 controls. Subsequent to processing the data to emphasise the shape of marker trajectories, the mean Movement Deviation Profile was generated for all @entity1 . This single number measure gives the deviation of a @entity1 's gait from a distributed definition of gait normality. Results showed that gait deviation roughly follows a sigmoid profile with minimal increase of gait deviations in a younger @entity1 group and an abrupt large increase around the second half of the 4th decade of life. Larger variations of gait deviations were found in the older group than in the younger group suggesting a complex interaction of multiple factors which determine gait function after symptoms manifest. Continued gait analysis of adults with @entity9360 , extended to younger adults and @entity1 with @entity9360 , is expected to complete understanding of both the natural history of @entity9360 and how interventions can affect movement function.

title: Age-Related Deviation of Gait from Normality in XXXX .

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disease']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'patients', 'patient']

entities_list: @entity9360 :: ('MESH:D000474', 'Disease') :: ['Alkaptonuria', 'AKU', 'alkaptonuria']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['arthropathy']

answer: @entity9360 :: (MESH:D000474,Disease) :: ['Alkaptonuria']


abstract: BACKGROUND: Cervical nerve root @entity155 after @entity130 is a well-known occurrence. It is associated with traction injuries to the brachial plexus, commonly after high-speed motor vehicle collisions. @entity614 @entity155 occurs when traction forces pull the nerve root sleeve into the intervertebral foramen with associated tearing of the meninges. The proximal nerve root retracts, and the neural foramen fills with cerebrospinal fluid and eventually forms a pseudomeningocele. Although imaging characteristics often include nerve root @entity4 and pseudomeningoceles, there has only been one description of associated @entity4282 in the literature. CASE DESCRIPTION: A 3-year-old @entity1 restrained in a passenger-side rear car seat presented to the emergency department after a high-speed motor vehicle collision. The @entity1 was found lying unconscious on the floor of the front passenger side. On arrival, she was flaccid with absent sensation in her left upper extremity, 3/5 strength in her right upper extremity, and full strength in her lower extremities. Computed tomography of the cervical spine was negative for acute @entity174 . Magnetic resonance imaging (MRI) of the cervical spine demonstrated a noncompressive @entity4282 from @entity2244 and MRI brachial plexus demonstrated diffuse left cervical nerve root @entity4 and @entity2244 @entity155 with pseudomeningoceles, which were not seen on the MRI cervical spine. The @entity1 was managed conservatively for her @entity2685 . CONCLUSIONS: Although pseudomeningocele formation after cervical nerve root @entity155 is commonly cited, associated @entity4282 are not well described. It is important to consider this etiology in @entity1 with asymmetric examinations and @entity4282 before surgical evacuation.

title: Posttraumatic Cervical Nerve Root XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patients', 'patient']

entities_list: @entity4282 :: ('MESH:D046748', 'Disease') :: ['epidural hematoma', 'epidural hematomas']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity155 :: ('MESH:D014084', 'Disease') :: ['avulsion']

entities_list: @entity614 :: ('MESH:D011843', 'Disease') :: ['Traumatic nerve root']

entities_list: @entity2685 :: ('MESH:C536265', 'Disease') :: ['brachial plexus injury']

answer: @entity4282 :: (MESH:D046748,Disease) :: ['Avulsion with Epidural Hematoma']


abstract: PURPOSE: This paper presents a new cognitive assistive technology, nonlinear contextually aware prompting system (N-CAPS) that uses advanced sensing and artificial intelligence to monitor and provide assistance to workers with @entity73 during a factory assembly task. METHODS: The N-CAPS system was designed through the application of various computer vision and artificial intelligence algorithms that allows the system to track a user during a specific assembly task, and then provide verbal and visual prompts to the worker as needed. A pilot study was completed with the N-CAPS solution in order to investigate whether it was an appropriate intervention. Four @entity1 completed the required assembly task five different times, using the N-CAPS system. RESULTS: The @entity1 completed all of the trials that they attempted with 85.7% of the steps completed without assistance from the job coach. Of the 85.7% of steps completed independently, 32.5% of these were completed in response to prompts given by N-CAPS. Overall system accuracy was 83.3%, the overall sensitivity was 86.2% and the overall specificity was 82.4%. CONCLUSIONS: The results from the study were positive in that they showed that this type of technology does have merit with this population. Implications for Rehabilitation It provides a concise summary of the importance of work in the lives of @entity1 with @entity717 and how technology can support this life goal. It describes the first artificially intelligent system designed to support workers with intellectually disabilities. It provides evidence that individuals with @entity717 can perform a work task in response to technology.

title: A nonlinear contextually aware prompting system (N-CAPS) to assist workers with XXXX to perform factory assembly tasks: system overview and pilot testing.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'people']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive disabilities']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['intellectual disabilities']

answer: @entity717 :: (MESH:D009069,Disease) :: ['intellectual and developmental disabilities']


abstract: Case 1 involved a 77-year-old @entity1 admitted to our hospital after he lost almost all memory of work on the day before. Diffusion-weighted imaging (DWI) revealed spotty hyperintensities in the bilateral hippocampi, which were considered responsible for the @entity2730 . Transesophageal echocardiography (TEE) showed severe aortic arch @entity1856 , 6.8   mm in diameter with extension to the branch. @entity887 to the bilateral hippocampi was diagnosed. Case 2 involved a 66-year-old @entity1 admitted to our hospital because she had lost all memory of the 5 hours she was out. She had transient anterograde @entity2730 . DWI revealed no @entity2806 , but magnetic resonance angiography (MRA) revealed @entity732 of the right posterior cerebral artery. MRA on hospital day 7 revealed partial recanalization. TEE showed aortic arch @entity1856 of 3.9   mm in diameter with extension to the branch. In both cases, aortogenic @entity887 to the hippocampus might have been causally related to transient @entity2414 . In @entity1 with acute @entity2414 , the possibility of @entity385 should be considered.

title: Two cases of ischemic cerebrovascular disease with only XXXX as neurological symptom and abnormal MR findings.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'man']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic lesions']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism', 'Aortogenic embolism']

entities_list: @entity732 :: ('MESH:D015356', 'Disease') :: ['branch occlusion']

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory disturbance']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity2414 :: (MESH:D008569,Disease) :: ['memory disturbance']


abstract: UNASSIGNED: A 19-year-old @entity1 with @entity1353 and @entity662 after strenuous exercise presented to emergency department . On physical examination, the neck and shoulders appeared to be swollen. There was crepitus on @entity272 . Chest X-ray disclosed @entity9285 and @entity14303 . CT showed additional finding of air in epidural space. The @entity1 was discharged after 2   days of hospitalisation with conservative treatment uneventfully. @entity51535 is usually caused by abrupt increase in intrathoracic pressure in instance of forceful @entity391 , cough or @entity565 attack in an otherwise healthy young adult. It is usually accompanied with @entity14303 . The management of epidural @entity14515 should be tailored according to its primary cause. For most @entity1 with @entity51535 associated to a spontaneous @entity14303 without @entity16 , this condition is generally self-limited. For epidural free air of large volume that causes @entity51 , surgical laminectomy may be indicated.

title: Teenager with XXXX and swollen neck: a leave-it-alone condition.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'boy']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity9285 :: ('MESH:D013352', 'Disease') :: ['diffuse subcutaneous emphysema']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity14303 :: ('MESH:D008478', 'Disease') :: ['pneumomediastinum']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits']

entities_list: @entity14515 :: ('MESH:D011006', 'Disease') :: ['pneumatosis']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin palpation']

entities_list: @entity51535 :: ('MESH:D063205', 'Disease') :: ['Pneumorrhachis', 'pneumorrhachis']

answer: @entity662 :: (MESH:D002637,Disease) :: ['chest pain']


abstract: Single test stimulation of the ventricle revealed initiation of echoes with a supraventricular QRS complex with a shorter P-R than R-P interval in 28 of 300 @entity1 consecutively studied with programmed electrical stimulation of the heart because of documented or suspected @entity591 . In all 28 the initiation of echoes was related to a discontinuity in the retrograde conduction curve. In 10 @entity1 a different atrial activation sequence in the endocavitary leads was present before and after the discontinuity in the retrograde conduction curve. In five of these a sustained @entity591 with a shorter P-R than R-P interval could be initiated, and in all five @entity1 an accessory pathway with a long conduction time as the retrograde arm of the @entity591 circuit could be demonstrated. In these five @entity1 spontaneous initiation of @entity591 was observed during sinus rhythm or after @entity11706 . @entity591 accelerated after the administration of @entity3897 . In the remaining 23 @entity1 the initiation of echoes showing a shorter P-R than R-P interval was nonsustained. In these @entity1 spontaneous @entity11705 or initiation by @entity11706 was not observed, and echoes with this relation of the P-R and R-P intervals systematically disappeared after administration of @entity3897 . It is postulated that in these @entity1 a slow atrioventricular (A-V) nodal pathway is used in the retrograde direction during echoes showing a shorter P-R than R-P interval. @entity713 junctional @entity591 showing this relation between P-R and R-P intervals favors incorporation of an accessory pathway with slow retrograde conduction in the @entity591 circuit.

title: Observations in XXXX showing A-V junctional echoes with a shorter P-R than R-P interval.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity11705 :: ('MESH:C563907', 'Disease') :: ['initiation of such echoes during sinus rhythm']

entities_list: @entity713 :: ('MESH:D054537', 'Disease') :: ['Sustained A-V']

entities_list: @entity11706 :: ('MESH:D018880', 'Disease') :: ['atrial premature beats']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['Tachycardia', 'tachycardia', 'tachycardias']

entities_list: @entity3897 :: ('MESH:D001285', 'Chemical') :: ['atropine']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Percutaneous endoscopic gastrostomy (PEG) tube placement is recommended in @entity746 ( @entity746 ) @entity1 with @entity1282 to provide reliable access for medications and nutrition. It is preferably done while forced vital capacity (FVC) is greater than 50% of predicted to reduce risk of postprocedural @entity1576 . Percutaneous radiologic gastrostomy has been shown to have higher success rates and lower complication rates compared with PEG. The authors sought to investigate the safety of PEG placement in @entity746 @entity1 with varying respiratory compromise. METHODS: The records of 21 @entity1 with @entity746 who underwent PEG tube placement from October 2010 to October 2013 were retrospectively reviewed to determine rates of successful placement, complication, mortality and survival. RESULTS: PEG was placed successfully in 95.2% of @entity1 . There was 1 major complication, procedure-related @entity204 , and failed placement in a @entity1 with FVC 15% predicted who developed procedure-related @entity1173 and @entity1576 and @entity204 8 days after failed PEG attempt. Minor complications included 3 @entity1 with minor @entity158 at insertion site, 1 @entity1 with minor bleeding requiring cauterization and 2 @entity1 requiring PEG tube replacement within 6 months of procedure for accidental dislodgement. After PEG placement, median survival was 327 days (95% confidence interval: 180-687). CONCLUSIONS: In conclusion, PEG tube placement in @entity1 with @entity746 seems to be a safe procedure in @entity1 without significant respiratory compromise. In @entity1 with FVC <50%, based on literature review and the results of this study, the authors recommend percutaneous radiologic gastrostomy over PEG placement.

title: Percutaneous Endoscopic Gastrostomy in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['hypoxic respiratory failure', 'respiratory complications']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis']

entities_list: @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspiration']

answer: @entity746 :: (MESH:D000690,Disease) :: ['Amyotrophic Lateral Sclerosis']


abstract: The use of barbiturates to induce @entity772 as a means of extending the period of reversible @entity2806 is reviewed. @entity17166 use in @entity1 who had had @entity64 or were undergoing @entity439 surgery was initially encouraging. In uncontrolled feasibility trials in @entity1 with @entity1167 or in deep @entity772 , 40 @entity1 received 10 mg/kg thiopental @entity1372 by i.v. push followed by 20 mg/kg thiopental @entity1372 i.v. over the next 30 minutes; 60% of these @entity1 regained consciousness. In a subgroup of 22 @entity1 who had @entity63 normally associated with a 90% mortality rate, 14 recovered completely. In the largest clinical trial, 45 @entity1 with severe @entity542 and elevated intracranial pressure received 3--5 mg/kg @entity4485 over 10--20 minutes. A serum @entity17166 level of 2.5--4.0 mg/dl was maintained for 14 days, and 30% of these @entity1 recovered but with @entity51 . Other results in @entity64 and drowning victims were not as encouraging. It is concluded that @entity17166 therapy is beneficial in the lowering of intracranial pressure. Focal and global @entity2806 have been shown amenable to @entity17166 therapy in isolated cases. The prophylactic use of barbiturates in surgical procedures requiring focal @entity12807 appears to be beneficial. Controlled trials of the use of @entity17166 -induced @entity772 are clearly indicated.

title: @entity17166 -induced @entity772 to protect against XXXX and increased intracranial pressure.

entities_list: @entity4485 :: ('MESH:D010424', 'Chemical') :: ['pentobarbital']

entities_list: @entity12807 :: ('MESH:D002534', 'Disease') :: ['cerebral anoxia']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury']

entities_list: @entity17166 :: ('MESH:C032232', 'Chemical') :: ['Barbiturate', 'barbiturate']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficits']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiopulmonary arrest']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['cerebral ischemia']


abstract: The use of barbiturates to induce @entity772 as a means of extending the period of reversible @entity2806 is reviewed. @entity17166 use in @entity1 who had had @entity64 or were undergoing @entity439 surgery was initially encouraging. In uncontrolled feasibility trials in @entity1 with @entity1167 or in deep @entity772 , 40 @entity1 received 10 mg/kg thiopental @entity1372 by i.v. push followed by 20 mg/kg thiopental @entity1372 i.v. over the next 30 minutes; 60% of these @entity1 regained consciousness. In a subgroup of 22 @entity1 who had @entity63 normally associated with a 90% mortality rate, 14 recovered completely. In the largest clinical trial, 45 @entity1 with severe @entity542 and elevated intracranial pressure received 3--5 mg/kg @entity4485 over 10--20 minutes. A serum @entity17166 level of 2.5--4.0 mg/dl was maintained for 14 days, and 30% of these @entity1 recovered but with @entity51 . Other results in @entity64 and drowning victims were not as encouraging. It is concluded that @entity17166 therapy is beneficial in the lowering of intracranial pressure. Focal and global @entity2806 have been shown amenable to @entity17166 therapy in isolated cases. The prophylactic use of barbiturates in surgical procedures requiring focal @entity12807 appears to be beneficial. Controlled trials of the use of @entity17166 -induced @entity772 are clearly indicated.

title: XXXX -induced @entity772 to protect against @entity2806 and increased intracranial pressure.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity17166 :: (MESH:C032232,Chemical) :: ['Barbiturate']


abstract: The use of barbiturates to induce @entity772 as a means of extending the period of reversible @entity2806 is reviewed. @entity17166 use in @entity1 who had had @entity64 or were undergoing @entity439 surgery was initially encouraging. In uncontrolled feasibility trials in @entity1 with @entity1167 or in deep @entity772 , 40 @entity1 received 10 mg/kg thiopental @entity1372 by i.v. push followed by 20 mg/kg thiopental @entity1372 i.v. over the next 30 minutes; 60% of these @entity1 regained consciousness. In a subgroup of 22 @entity1 who had @entity63 normally associated with a 90% mortality rate, 14 recovered completely. In the largest clinical trial, 45 @entity1 with severe @entity542 and elevated intracranial pressure received 3--5 mg/kg @entity4485 over 10--20 minutes. A serum @entity17166 level of 2.5--4.0 mg/dl was maintained for 14 days, and 30% of these @entity1 recovered but with @entity51 . Other results in @entity64 and drowning victims were not as encouraging. It is concluded that @entity17166 therapy is beneficial in the lowering of intracranial pressure. Focal and global @entity2806 have been shown amenable to @entity17166 therapy in isolated cases. The prophylactic use of barbiturates in surgical procedures requiring focal @entity12807 appears to be beneficial. Controlled trials of the use of @entity17166 -induced @entity772 are clearly indicated.

title: @entity17166 -induced XXXX to protect against @entity2806 and increased intracranial pressure.

answer: @entity772 :: (MESH:D003128,Disease) :: ['coma']


abstract: UNASSIGNED: Background and study aims: The clinical utility of computed virtual chromoendoscopy with flexible spectral imaging color enhancement (FICE) in capsule endoscopy (CE) remains controversial. To clarify the clinical utility of FICE-enhanced CE in evaluating @entity29 , we quantitatively assessed white light (WL), FICE, and blue mode (BM) images and examined the sensitivity of these 3 imaging modes of small-bowel lesions from @entity1 who underwent CE. Methods: The CIELAB color difference (   E) and visual analogue scales (VAS) were measured in 261CE images (3 different lesion categories) using WL and FICE set 1, 2, and 3, and BM images, respectively. Three endoscopists reviewed CE videos with WL, 3 FICE mode settings, and BM, and compared the sensitivity and detectability for small intestinal diseases from 50 @entity1 who underwent CE. Results: In the assessment of visibility in the 152 vascular lesion images, the    E and VAS of FICE set 1, 2, and BM images were significantly higher than that of WL images. In 88 @entity2681 /ulceration images, the    E and VAS of FICE set 1 and 2 images were significantly higher than that of WL images. In 21 @entity5 images, there were no significant differences in    E among these modalities. When analyzed on a per- @entity1 basis, FICE settings 1 and 2 had the highest sensitivity (100%) and specificity (97.3-100%) for @entity455 . As for erosive/ulcerative lesions, FICE setting 2 had the highest sensitivity (100%) and specificity (97.2%). For @entity5 or @entity1127 , WL had the highest sensitivity (90.9%) and specificity (87.1%). In per-lesion analysis, FICE settings 1 and 2 showed significantly superior detection ability over WL for @entity455 . In the detection of erosive/ulcerative lesions, FICE setting 2 was significantly superior to WL. In @entity5 images, there was no significant improvement with any of the settings relative to WL images. Conclusions: FICE is most useful for improving CE image quality and detection in cases of angioectasia and @entity2681 /ulceration of the small intestine.

title: Clinical utility of capsule endoscopy with flexible spectral imaging color enhancement for diagnosis of XXXX .

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['small bowel lesions']

answer: @entity29 :: (MESH:D015212,Disease) :: ['small bowel lesions']


abstract: INTRODUCTION: @entity439 repair (EVAR) is a comparatively less invasive technique than open repair (OR). Debate remains with regard to the benefit of EVAR for @entity1 with @entity1755 ( @entity1755 ). We sought to evaluate and report outcomes of EVAR for @entity1755 in an Irish tertiary vascular referral centre. METHODS: @entity1 undergoing emergency surgery for ruptured or symptomatic @entity11557 were identified from theatre logbooks and HIPE database. Retrospective chart review was undertaken. Data were exported to IBM SPSS version 21 for statistical analysis with p  <  0.05 considered significant. RESULTS: A total of 41 @entity1 underwent surgery for @entity1755 . The mean age was 74 years old with a range from 55 to 89 years. The majority (n  =  25, 61%) were baseline American Society of Anaesthesiology (ASA) grade 3-4. Of these 56% underwent EVAR with the remaining 44% repaired open. Mortality rate in those undergoing emergency EVAR was 34.8%, compared with 38.9% in those undergoing open surgery. This difference was not statistically significant. The mean overall length of stay was 13 days. With regard to prognostic indicators of @entity1 outcome, increasing @entity1 age was noted to be significantly associated with increased mortality (p  =  0.013), as was increased ASA score at time of surgery (p  =  0.029). CONCLUSIONS: Mortality rates in those undergoing EVAR for @entity1755 are comparable with those undergoing open repair. Increasing age and ASA score are significant predictors of mortality in @entity1 with @entity1755 undergoing intervention.

title: Endovascular versus open repair of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['Endovascular aneurysm']

entities_list: @entity1755 :: ('MESH:D001019', 'Disease') :: ['ruptured abdominal aortic aneurysm', 'RAAA']

answer: @entity1755 :: (MESH:D001019,Disease) :: ['ruptured abdominal aortic aneurysm']


abstract: BACKGROUND: Negative pressure wound therapy (NPWT) is a widely accepted method of temporary coverage for complex lower extremity wounds before definitive reconstruction. However, the precise role of NPWT in the perioperative management of @entity1 with complicated lower @entity130 remains unclear. In this study, we examine the effect of NPWT on flap complications and overall outcomes based on timing of soft-tissue reconstruction relative to @entity130 . METHODS: We retrospectively reviewed the medical records of 32 consecutive @entity1 presenting to a single institution receiving lower extremity reconstruction after Gustilo class IIIB or IIIC open @entity174 over a 5-y period. Length of hospitalization, number of surgical procedures, flap failure, infection, and nonunion were parameters of interest in this study. RESULTS: The incidence of complications in @entity1 treated with NPWT was lower compared with @entity1 who underwent wet-to-dry dressing changes, regardless of when surgery was performed. The highest rate of complications was observed in @entity1 operated on >6  wk after injury and who received wet-to-dry dressing changes wound care. By comparison, those who underwent surgery within 1  wk of injury and who were bridged with NPWT had the lowest rate of complications. CONCLUSIONS: The use of NPWT therapy in the perioperative management of @entity1 with open lower extremity @entity174 reduces complication rates associated with limb salvage surgery. Our results suggest that NPWT can be used as a temporizing measure to optimize @entity1 before flap surgery, effectively lengthening the window of opportunity for definitive reconstruction.

title: The use of negative pressure wound therapy in severe open lower extremity XXXX : identifying the association between length of therapy and surgical outcomes.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'tibial fractures']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['initial injury and implementation of NPWT', 'extremity injuries']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: @entity5 chronotherapy aims at enhancing tolerability and efficacy of anticancer drugs through their delivery according to circadian clocks. However, @entity19 and @entity1 data show that lifestyle, sex, genetics, drugs, and @entity5 can modify both host circadian clocks and metabolism pathways dynamics, and thus the optimal timing of drug administration. The mathematical modeling of chronopharmacology could indeed help moderate optimal timing according to @entity1 -specific determinants. Here, we combine in vitro and in silico methods, in order to characterize the critical molecular pathways that drive the chronopharmacology of @entity2600 , a topoisomerase I inhibitor with complex metabolism and known activity against @entity14 . Large transcription rhythms moderated drug bioactivation, detoxification, transport, and target in synchronized @entity14 . These molecular rhythms translated into statistically significant changes in pharmacokinetics and pharmacodynamics according to in vitro circadian drug timing. The top-up of the multiple coordinated chronopharmacology pathways resulted in a four-fold difference in @entity2600 -induced apoptosis according to drug timing. @entity2600 @entity137 was directly linked to clock gene @entity8713 expression: The least apoptosis resulted from drug exposure near @entity8713 mRNA nadir (P < 0.001), whereas clock silencing through siBMAL1 exposure ablated all the chronopharmacology mechanisms. Mathematical modeling highlighted circadian bioactivation and detoxification as the most critical determinants of @entity2600 chronopharmacology. In vitro-in silico systems chronopharmacology is a new powerful methodology for identifying the main mechanisms at work in order to optimize circadian drug delivery.

title: Identification of Circadian Determinants of XXXX Chronotherapy through In Vitro Chronopharmacology and Mathematical Modeling.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity2600 :: ('MESH:C051890', 'Chemical') :: ['Irinotecan', 'irinotecan']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer cell cultures', 'colorectal cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: OBJECTIVES: In @entity1 , @entity2178 type 1 and 2 receptors ( @entity7743 and AT2R) have been implicated in trophoblast invasion and placental development. Since the utero-placental unit of @entity840 (GP) and @entity1 share a morphologic structure, hormonal, vasodilator patterns and uterine spiral artery remodeling, this species was deemed suitable to study the spatio-temporal expression of the vasoconstrictive ( @entity7743 ) and vasodilator (AT2R) receptors of @entity2178 . METHODS: Utero-placental units were collected in days (D) 15, 20, 40 and 60 of a 64-67days long pregnancy in Pirbright White @entity840 (n=3 per period). The localization and intensity of expression of @entity7743 and AT2R in different structures of utero-placental units was evaluated by immunohistochemistry. Additionally immunogold electron microscopy for both receptors was performed in day 60. RESULTS: @entity7743 and AT2R were detected along pregnancy in the interlobium, the endothelium and syncytiotrophoblast of the placental labyrinth, subplacenta, giant cells, syncytial streamers, decidua, vascular smooth muscle of spiral arteries and myometrium; in day 20 in perivascular and intramural trophoblasts, while in late pregnancy these were observed in endoluminal trophoblasts in lateral and myometrial spiral arteries. The immunoreactivity of @entity7743 and AT2R was prominent in D15 in syncytial streamers and in D40 in intramural and intraluminal trophoblasts. Immunoelectron microscopy in D60 demonstrated both receptors in cell membrane, cytosol (cyt) and nucleus (nu) in the placenta (Figure). CONCLUSIONS: The spatial pattern of @entity7743 and AT2R supports their association with decidualization, trophoblast invasion, vascular remodeling. This similarity with the @entity1 , added to an analogous intracellular localization of @entity7743 , validates the use of @entity840 to understand the local adaptations of pregnancy. Supported by Fondecyt 1121161 DISCLOSURES: S. Acuna: None. G. Valdes: None.

title: [107-POS] : Cellular and subcellular localization of angiotensin AT1 and AT2 receptors in XXXX utero-placental units along pregnancy.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity2178 :: ('183', 'Gene') :: ['angiotensin II']

answer: @entity840 :: (10141,Species) :: ['guinea-pig']


abstract: OBJECTIVES: @entity1 who experienced @entity101 pregnancy need life-long follow up of blood pressure, due to the higher risk of later @entity65 . However, routine visit for practitioner is sometimes difficult for postpartum mothers because of her lifestyle or the distance to doctors. In this study, we investigated the usability of mobile sphygmomanometer for follow up of @entity101 pregnancy. METHODS: One multi-para pregnant subject complicated with @entity1252 (#1) and other multi-para who experienced severe @entity1468 and @entity2102 at 32 weeks' gestation in former pregnancy (#2) were recruited to the trial of use web-linked sphygmomanometer (HEM-7251G with MedLINK system, Omron, Japan). Next, two mild @entity101 @entity1 who successfully given birth (#3, who experienced @entity2102 in former pregnancy; #4 without medication) who moved to the distant area (100 km and 500 km from our hospital) were recruited for the trial for 6 months with informed consent. Blood pressure data were automatically sent twice a day after their measurement. The data were gathered, analyzed and seen on a secured website. RESULTS: All @entity1 completed their measurement twice a day without any technical problem. The @entity1 #1 had a normal spontaneous delivery and #2 is now planned for cesarean section with no complications. Average systolic blood pressure of the @entity1 #3 was 135  11mmHg at morning and 136   12 at evening, and of #4 was 135  11 and 140  12. No @entity101 emergency was observed in all @entity1 . CONCLUSIONS: The compliance of the @entity1 for the routine measurement of their blood pressure was notably good and produced good check-up of their health condition, both in pregnancy and on postpartum period in the distant area. A problem to be solved is corroboration with regional emergency care system when the @entity1 experienced the @entity101 emergency. DISCLOSURES: S. Onishi: None. K. Nakano: None. K. Iwai: None. Y. Yamada: None. J. Akasaka: None. A. Shigemitsu: None. K. Naruse: None. H. Kobayashi: None.

title: [165-POS] : Postpartum follow-up of XXXX pregnancy using at-home web-linked mobile sphygmomanometer.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Women', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity2102 :: ('MESH:D017359', 'Disease') :: ['HELLP syndrome']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['systemic lupus erythematosus']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: This study sought to determine the diagnostic utility of perfusion parameters derived from dynamic contrast-enhanced (DCE) perfusion MRI with a short acquisition time (approximately 3.5  min) in @entity1 with @entity11 , @entity75 , and @entity706 ( @entity706 ). Twenty-six @entity1 with 29 lesions (4 @entity11 , 13 high-grade @entity11 , 7 @entity3 , and 5 @entity706 ) underwent DCE-MRI in a 3  T scanner. A ROI was placed on the hotspot of each @entity5 in maps for volume transfer contrast K (trans) , extravascular extracellular volume V e , and fractional plasma volume V p . We analyzed differences in parameters between @entity5 using the Mann-Whitney U test. We calculated sensitivity and specificity using receiver operating characteristics analysis. Mean K (trans) values of LGG, HGG, @entity3 and @entity706 were 0.034, 0.31, 0.38, 0.44, respectively. Mean Ve values of each @entity5 was 0.036, 0.57, 0.47, 0.96, and mean Vp value of each @entity5 was 0.070, 0.086, 0.26, 0.17, respectively. Compared with other @entity5 types, @entity11 showed lower K (trans) (P   <   0.01, sensitivity   =   88%, specificity   =   100%) and lower V e (P   <   0.01, sensitivity   =   96%, specificity   =   100%). @entity706 showed higher V e (P   <   0.01, sensitivity   =   100%, specificity   =   88%), but the other perfusion parameters overlapped with those of different histology. Kinetic parameters derived from DCE-MRI with short acquisition time provide useful information for the differential diagnosis of @entity1313 .

title: Diagnosis of XXXX using dynamic contrast-enhanced perfusion imaging with a short acquisition time.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['PCNSL', 'primary CNS lymphoma']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain metastasis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['glioma', 'low-grade glioma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1313 :: (MESH:D001932,Disease) :: ['brain tumors']


abstract: Background. Triweekly @entity900 -based postoperative concurrent chemoradiotherapy (CCRT) has high intolerance and @entity137 in locally advanced @entity135 (LAHNC). We evaluated the effect of a modified weekly @entity900 -based chemotherapy in postoperative CCRT. Methods. A total of 117 @entity1 with LAHNC were enrolled between December 2007 and December 2012. Survival, compliance/adverse events, and independent prognostic factors were analyzed. Results. Median follow-up time was 30.0 (3.1-73.0) months. Most @entity1 completed the entire course of postoperative CCRT (radiotherapy >=  60   Gy, 94.9%; >= 6 times weekly chemotherapy, 75.2%). Only 17.1% @entity1 required hospital admission. The most common adverse effect was grade 3/4 @entity33 (28.2%). No @entity1 died due to protocol-related adverse effects. Multivariate analysis revealed the following independent prognostic factors: @entity5 , extracapsular spread, and total radiation dose. Two-year progression-free survival and overall survival rates were 70.9% and 79.5%, respectively. Conclusion. Modified weekly @entity900 -based chemotherapy is an acceptable regimen in postoperative CCRT for LAHNC.

title: Modified weekly XXXX -based chemotherapy is acceptable in postoperative concurrent chemoradiotherapy for locally advanced @entity135 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['oropharyngeal cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['Cisplatin']


abstract: Background. Triweekly @entity900 -based postoperative concurrent chemoradiotherapy (CCRT) has high intolerance and @entity137 in locally advanced @entity135 (LAHNC). We evaluated the effect of a modified weekly @entity900 -based chemotherapy in postoperative CCRT. Methods. A total of 117 @entity1 with LAHNC were enrolled between December 2007 and December 2012. Survival, compliance/adverse events, and independent prognostic factors were analyzed. Results. Median follow-up time was 30.0 (3.1-73.0) months. Most @entity1 completed the entire course of postoperative CCRT (radiotherapy >=  60   Gy, 94.9%; >= 6 times weekly chemotherapy, 75.2%). Only 17.1% @entity1 required hospital admission. The most common adverse effect was grade 3/4 @entity33 (28.2%). No @entity1 died due to protocol-related adverse effects. Multivariate analysis revealed the following independent prognostic factors: @entity5 , extracapsular spread, and total radiation dose. Two-year progression-free survival and overall survival rates were 70.9% and 79.5%, respectively. Conclusion. Modified weekly @entity900 -based chemotherapy is an acceptable regimen in postoperative CCRT for LAHNC.

title: Modified weekly @entity900 -based chemotherapy is acceptable in postoperative concurrent chemoradiotherapy for locally advanced XXXX .

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck cancer']


abstract: The purification of the various types of cells in solid @entity5 is necessary for study of their biochemical and immunological functions. The R3230AC @entity420 contains both a variety of stromal cells and well-differentiated neoplastic cells that possess many of the biosynthetic capabilities of normal @entity35 mammary cells. Suspensions of cells from @entity5 weighing less than 1.2 g consisted of 70.4 +/- 7.2% (S.D.) malignant cells by morphology, 6.8 +/- 3.0% lymphocytes, 6.3 +/- 3.2% macrophages, 15.2 +/- 5.2% red blood cells, 0.8 +/- 0.5% granulocytes, and 0.5 +/- 0.6% unidentified cells. Sedimentation of the cells from the R3230AC @entity5 in a previously described isokinetic gradient resulted in a 5- to 6-fold purification of lymphocytes and macrophages. The modal fraction of malignant cells contained 95.3 +/- 2.9% malignant cells. Detection of alpha-lactalbumin by the direct peroxidase conjugate technique gave vacuolar staining of malignant cells, in contrast to the indirect and peroxidase-antiperoxidase techniques which stained ducts from normal lactating mammary gland and a wide variety of cells without vacuoles in the @entity5 . The best fixative for frozen sections, paraffin-embedded tissue, and cell suspensions was 50% @entity1068 -50% @entity1324 . The suspensions of @entity5 cells contained 14.4 +/- 9.4% cells with histochemically demonstrable alpha-lactalbumin. Squamous metaplasia was commonly observed in @entity5 than lactating @entity35 .

title: Separation and characterization of the neoplastic and stromal elements of the R3230AC mammary XXXX .

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma']


abstract: UNASSIGNED: Literature comparing 'jumping to conclusions' (JTC) between @entity1 and healthy controls has demonstrated the importance of the reasoning bias in the development of delusions. When groups that vary along the entire delusional continuum are included, the relationship between JTC and delusionality is less clear. This study compared JTC and delusional dimensions between 28 @entity1 with delusions, 35 delusion-prone individuals and 32 non-delusion-prone individuals. Delusion proneness was defined by an established threshold based on the Peters et al. @entity8143 Inventory. Two versions of the beads task (85:15 and 60:40) were used to measure JTC. As hypothesized, @entity1 manifested hastier data gathering than the two non-clinical groups on both beads tasks. However, delusion-prone individuals did not manifest a hastier decision making style than non-delusion prone individuals. Instead, non-delusion-prone @entity1 showed more JTC bias than delusion-prone individuals on the easier beads task. There was no evidence for a dose-response relationship between JTC and delusional dimensions, with correlations between JTC and PDI scores found in the non-delusion-prone group only. The present finding confirms the link between an extreme JTC bias and the presence of clinical delusions, and argues against a linear relationship between JTC and delusionality along the symptomatic continuum.

title: Jumping to Conclusions Style along the Continuum of XXXX : Delusion-Prone Individuals Are Not Hastier in Decision Making than Healthy Individuals.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity8143 :: ('MESH:D063726', 'Disease') :: ['Delusions']

answer: @entity8143 :: (MESH:D063726,Disease) :: ['Delusions']


abstract: OBJECTIVE: The purpose of this article is to determine whether MRI features of @entity1358 ( @entity1358 ), such as enhancing solid component and T1 signal intensity, are associated with clinicopathologic outcomes. MATERIALS AND METHODS: This retrospective study included 241 RCCs in 230 @entity1 who underwent preoperative MRI, had pathologic analysis results available, and were monitored for at least 3 months. A radiologist assessed @entity5 features on MRI, including unenhanced T1 signal relative to renal cortex and the percentage of solid enhancing components. The electronic medical record or follow-up images were reviewed to assess for the development of local recurrence or @entity3 . Statistical analysis was performed to correlate imaging features at MRI with pathologic and clinical outcome. RESULTS: The following @entity5 features were observed: predominantly cystic morphologic features (defined as solid component  <= 25%, n = 33), solid component greater than 25% (n = 208), T1 hypointensity (n = 97), and T1 intermediate intensity or hyperintensity (n = 144). Local recurrence or @entity3 were observed in 14 @entity1 . Compared with T1-intermediate or -hyperintense lesions, T1-hypointense RCCs were more likely to be low stage (90.7% vs 74.3%; p = 0.001) and low grade (78.9% vs 41.8%; p < 0.001) and had a lower rate of recurrence or @entity3 (3.3% vs 8%; p = 0.167). Compared with lesions with greater than 25% solid enhancement, predominantly cystic RCCs were more likely to be lower stage (93.9% vs 78.8%; p = 0.053) and lower grade (94.7 vs 56.5%; p < 0.001) and to have no incidence of recurrence or @entity3 (0% vs 6.9%; p = 0.227). RCCs that were both cystic and T1 hypointense (n = 14) were lower stage (100% vs 79.6%; p = 0.047) and lower grade (92.9% vs 58.1%; p = 0.01) and had no recurrence or @entity3 on follow-up. CONCLUSION: Cystic and T1-hypointense @entity1358 show less-aggressive pathologic features and favorable clinical behavior.

title: MRI Features of XXXX That Predict Favorable Clinicopathologic Outcomes.

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma', 'RCC']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['Renal Cell Carcinoma']


abstract: OBJECTIVES: The aim of this study was to describe the role of contrast-enhanced cardiac magnetic resonance (CMR) in the workup of @entity1 with @entity1164 ( @entity1164 ) and in the prediction of long-term outcomes. BACKGROUND: @entity296 is a key substrate for @entity1164 , and late @entity2287 enhancement (LGE) on a CMR study is a robust technique for imaging of @entity296 . METHODS: We performed a retrospective review of all survivors of @entity1164 who were referred for CMR studies and performed follow-up for the subsequent occurrence of an adverse event ( @entity204 and appropriate defibrillator therapy). RESULTS: After a workup that included a clinical history, electrocardiogram, echocardiography, and coronary angiogram, 137 @entity1 underwent CMR for workup of @entity1164 (66% male; mean age 56    11 years; left ventricular ejection  fraction 43    12%). The presenting @entity943 were @entity2224 (n  = 105 [77%]) and @entity1165 (n  = 32 [23%]). Overall, LGE was found in 98 @entity1 (71%), with an average extent of 9.9    5% of the left ventricular myocardium. CMR imaging provided a diagnosis or an arrhythmic substrate in 104 @entity1 (76%), including the presence of an infarct-pattern LGE in 60 @entity1 (44%), noninfarct LGE in 21 (15%), active @entity2401 in 14 (10%), @entity1121 in 3 (2%), @entity370 in 3, and arrhythmogenic @entity296 in 3. In a median follow-up of 29 months (range 18 to 43 months), there were 63 events. In a multivariable analysis, the strongest predictors of recurrent events were the presence of LGE (adjusted hazard ratio: 6.7; 95% CI: 2.38 to 18.85; p  < 0.001) and the extent of LGE (hazard ratio: 1.15; 95% CI: 1.11 to 1.19; p  < 0.001). CONCLUSIONS: Among @entity1 with @entity1164 , CMR with contrast identified LGE in 71% and provided a potential arrhythmic  substrate in 76%. In follow-up, both the presence and extent of LGE identified a group at markedly increased risk of future adverse events.

title: Late XXXX enhancement among survivors of @entity1164 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['aborted sudden cardiac arrest', 'aborted SCA', 'SCA']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'myocardial fibrosis', 'Myocardial fibrosis']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity1121 :: ('MESH:D002312', 'Disease') :: ['hypertrophic cardiomyopathy']

entities_list: @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['gadolinium']

entities_list: @entity2401 :: ('MESH:D009205', 'Disease') :: ['myocarditis']

answer: @entity2287 :: (MESH:D005682,Chemical) :: ['gadolinium']


abstract: OBJECTIVES: The aim of this study was to describe the role of contrast-enhanced cardiac magnetic resonance (CMR) in the workup of @entity1 with @entity1164 ( @entity1164 ) and in the prediction of long-term outcomes. BACKGROUND: @entity296 is a key substrate for @entity1164 , and late @entity2287 enhancement (LGE) on a CMR study is a robust technique for imaging of @entity296 . METHODS: We performed a retrospective review of all survivors of @entity1164 who were referred for CMR studies and performed follow-up for the subsequent occurrence of an adverse event ( @entity204 and appropriate defibrillator therapy). RESULTS: After a workup that included a clinical history, electrocardiogram, echocardiography, and coronary angiogram, 137 @entity1 underwent CMR for workup of @entity1164 (66% male; mean age 56    11 years; left ventricular ejection  fraction 43    12%). The presenting @entity943 were @entity2224 (n  = 105 [77%]) and @entity1165 (n  = 32 [23%]). Overall, LGE was found in 98 @entity1 (71%), with an average extent of 9.9    5% of the left ventricular myocardium. CMR imaging provided a diagnosis or an arrhythmic substrate in 104 @entity1 (76%), including the presence of an infarct-pattern LGE in 60 @entity1 (44%), noninfarct LGE in 21 (15%), active @entity2401 in 14 (10%), @entity1121 in 3 (2%), @entity370 in 3, and arrhythmogenic @entity296 in 3. In a median follow-up of 29 months (range 18 to 43 months), there were 63 events. In a multivariable analysis, the strongest predictors of recurrent events were the presence of LGE (adjusted hazard ratio: 6.7; 95% CI: 2.38 to 18.85; p  < 0.001) and the extent of LGE (hazard ratio: 1.15; 95% CI: 1.11 to 1.19; p  < 0.001). CONCLUSIONS: Among @entity1 with @entity1164 , CMR with contrast identified LGE in 71% and provided a potential arrhythmic  substrate in 76%. In follow-up, both the presence and extent of LGE identified a group at markedly increased risk of future adverse events.

title: Late @entity2287 enhancement among survivors of XXXX .

answer: @entity1164 :: (MESH:D016757,Disease) :: ['sudden cardiac arrest']