abstract: The genetic defect of @entity5337 , known as @entity5337 , produces a resistance to degradation by activated protein C and @entity49 . However, the role of @entity5337 in the formation of left @entity715 with nonrheumatic @entity955 has not been studied. We investigated whether @entity5337 is a risk factor for left @entity715 in @entity1 with nonrheumatic @entity955 . We analyzed clinical, echocardiographic, and biochemical data in 105 consecutive @entity1 with nonrheumatic @entity955 . These @entity1 were divided into two groups: group A (n = 37) with left @entity715 and group B (n = 68) without left @entity715 . The study also included 42 control subjects. Left @entity715 was investigated by using both transthoracic echocardiography and transesophageal echocardiography. Blood samples from the @entity1 and controls were analyzed for the @entity5337 mutation by DNA analysis, using the polymerase chain reaction. There was no significant difference in the prevalence of @entity5337 between the @entity1 and control subjects. The prevalence of @entity5337 mutation was 8.1% (3/37) in @entity1 with left @entity715 , and 8.8% (6/68) in @entity1 without left @entity715 . The prevalence of @entity5337 was 7.1% (3/42) in control subjects. The prevalance of @entity5337 was 10% (2/20) in @entity1 with spontaneous echo contrast and 8% (7/85) in @entity1 without spontaneous echo contrast. Multivariate analyses showed that left ventricular ejection fraction was an independent predictor of left @entity715 . @entity5337 mutation is not a risk factor for left @entity715 formation and spontaneous echo contrast in @entity1 with nonrheumatic @entity955 .

title: XXXX mutation and its relation to left @entity715 in chronic nonrheumatic @entity955 .

entities_list: @entity5337 :: ('2153', 'Gene') :: ['Factor V Leiden', 'factor V Leiden', 'coagulation factor V']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity49 :: ('MESH:D019851', 'Disease') :: ['increased venous thrombosis']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['atrial thrombus']

answer: @entity5337 :: (2153,Gene) :: ['Factor V Leiden']


abstract: The genetic defect of @entity5337 , known as @entity5337 , produces a resistance to degradation by activated protein C and @entity49 . However, the role of @entity5337 in the formation of left @entity715 with nonrheumatic @entity955 has not been studied. We investigated whether @entity5337 is a risk factor for left @entity715 in @entity1 with nonrheumatic @entity955 . We analyzed clinical, echocardiographic, and biochemical data in 105 consecutive @entity1 with nonrheumatic @entity955 . These @entity1 were divided into two groups: group A (n = 37) with left @entity715 and group B (n = 68) without left @entity715 . The study also included 42 control subjects. Left @entity715 was investigated by using both transthoracic echocardiography and transesophageal echocardiography. Blood samples from the @entity1 and controls were analyzed for the @entity5337 mutation by DNA analysis, using the polymerase chain reaction. There was no significant difference in the prevalence of @entity5337 between the @entity1 and control subjects. The prevalence of @entity5337 mutation was 8.1% (3/37) in @entity1 with left @entity715 , and 8.8% (6/68) in @entity1 without left @entity715 . The prevalence of @entity5337 was 7.1% (3/42) in control subjects. The prevalance of @entity5337 was 10% (2/20) in @entity1 with spontaneous echo contrast and 8% (7/85) in @entity1 without spontaneous echo contrast. Multivariate analyses showed that left ventricular ejection fraction was an independent predictor of left @entity715 . @entity5337 mutation is not a risk factor for left @entity715 formation and spontaneous echo contrast in @entity1 with nonrheumatic @entity955 .

title: @entity5337 mutation and its relation to left @entity715 in chronic nonrheumatic XXXX .

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: The genetic defect of @entity5337 , known as @entity5337 , produces a resistance to degradation by activated protein C and @entity49 . However, the role of @entity5337 in the formation of left @entity715 with nonrheumatic @entity955 has not been studied. We investigated whether @entity5337 is a risk factor for left @entity715 in @entity1 with nonrheumatic @entity955 . We analyzed clinical, echocardiographic, and biochemical data in 105 consecutive @entity1 with nonrheumatic @entity955 . These @entity1 were divided into two groups: group A (n = 37) with left @entity715 and group B (n = 68) without left @entity715 . The study also included 42 control subjects. Left @entity715 was investigated by using both transthoracic echocardiography and transesophageal echocardiography. Blood samples from the @entity1 and controls were analyzed for the @entity5337 mutation by DNA analysis, using the polymerase chain reaction. There was no significant difference in the prevalence of @entity5337 between the @entity1 and control subjects. The prevalence of @entity5337 mutation was 8.1% (3/37) in @entity1 with left @entity715 , and 8.8% (6/68) in @entity1 without left @entity715 . The prevalence of @entity5337 was 7.1% (3/42) in control subjects. The prevalance of @entity5337 was 10% (2/20) in @entity1 with spontaneous echo contrast and 8% (7/85) in @entity1 without spontaneous echo contrast. Multivariate analyses showed that left ventricular ejection fraction was an independent predictor of left @entity715 . @entity5337 mutation is not a risk factor for left @entity715 formation and spontaneous echo contrast in @entity1 with nonrheumatic @entity955 .

title: @entity5337 mutation and its relation to left XXXX in chronic nonrheumatic @entity955 .

answer: @entity715 :: (MESH:D013927,Disease) :: ['atrial thrombus']


abstract: OBJECTIVES: Use of the heterotopic @entity35 cardiac isograft model is limited by ventricular @entity194 attributable to the left ventricle's non-working state. Previous studies indicate that increased left ventricular pressure-volume work minimizes @entity194 . We used a simpler approach to increase ventricular work, imposing @entity337 on the transplant. We hypothesized that this would prevent @entity194 and preserve left ventricular compliance. METHODS: We analyzed heterotopic transplants with aortic valvotomy and without aortic valvotomy (controls). Recipient native hearts served as separate controls. After 15 to 25 days, we measured cardiac wet weight, dry weight, and water content of all groups and measured echocardiographic left ventricular wall thickness and end-diastolic and end-systolic diameters in both transplant groups. Left ventricular volume infusions yielded pressure-volume data that we analyzed using regression methods. RESULTS: Aortic regurgitant transplants weighed more than control transplants (dry weight, 0.109 +/- 0.013 g vs 0.097 +/- 0.016 g; p = 0.020, 2-way analysis of variance), but all transplants weighed less than native hearts weighed (p = 0.001). Control transplants were less compliant than regurgitant transplants (p = 0.002), but the latter were similar to their own native hearts (p = 0.34). Wall thickness decreased in regurgitant vs control transplants (p = 0.020, Student's t-test), but end-diastolic and end-systolic diameters increased (p < or = 0.001). CONCLUSIONS: @entity337 in heterotopic transplants improves left ventricular compliance through chamber dilatation without preventing @entity194 . Moderate acute @entity337 affects ventricular remodeling more than it stimulates @entity1283 . Smaller end-diastolic diameter, greater wall thickness, and @entity296 may explain decreased compliance in non-working transplants.

title: XXXX in the heterotopic @entity35 heart transplant: effect on ventricular remodeling and diastolic function.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial edema']

entities_list: @entity1283 :: ('MESH:D006332', 'Disease') :: ['myocardial hypertrophy']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['Aortic regurgitation', 'aortic regurgitation']

answer: @entity337 :: (MESH:D001022,Disease) :: ['Aortic regurgitation']


abstract: OBJECTIVES: Use of the heterotopic @entity35 cardiac isograft model is limited by ventricular @entity194 attributable to the left ventricle's non-working state. Previous studies indicate that increased left ventricular pressure-volume work minimizes @entity194 . We used a simpler approach to increase ventricular work, imposing @entity337 on the transplant. We hypothesized that this would prevent @entity194 and preserve left ventricular compliance. METHODS: We analyzed heterotopic transplants with aortic valvotomy and without aortic valvotomy (controls). Recipient native hearts served as separate controls. After 15 to 25 days, we measured cardiac wet weight, dry weight, and water content of all groups and measured echocardiographic left ventricular wall thickness and end-diastolic and end-systolic diameters in both transplant groups. Left ventricular volume infusions yielded pressure-volume data that we analyzed using regression methods. RESULTS: Aortic regurgitant transplants weighed more than control transplants (dry weight, 0.109 +/- 0.013 g vs 0.097 +/- 0.016 g; p = 0.020, 2-way analysis of variance), but all transplants weighed less than native hearts weighed (p = 0.001). Control transplants were less compliant than regurgitant transplants (p = 0.002), but the latter were similar to their own native hearts (p = 0.34). Wall thickness decreased in regurgitant vs control transplants (p = 0.020, Student's t-test), but end-diastolic and end-systolic diameters increased (p < or = 0.001). CONCLUSIONS: @entity337 in heterotopic transplants improves left ventricular compliance through chamber dilatation without preventing @entity194 . Moderate acute @entity337 affects ventricular remodeling more than it stimulates @entity1283 . Smaller end-diastolic diameter, greater wall thickness, and @entity296 may explain decreased compliance in non-working transplants.

title: @entity337 in the heterotopic XXXX heart transplant: effect on ventricular remodeling and diastolic function.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: Small airway remodeling is an important cause of the airflow limitation in @entity1030 ( @entity1030 ). A large population of @entity1 with @entity1030 also have @entity120 . Kr  ppel-like factor 5 ( @entity26004 ) is a @entity219 -finger transcription factor that contributes to tissue remodeling in @entity65 . Here, we evaluate the possible involvement of @entity26004 in the remodeling of small airways and pulmonary vessels in @entity1030 . METHODS: Lung tissues were obtained from 23 control never-smokers, 17 control ex-smokers and 24 ex-smokers with @entity1030 . The expression of @entity26004 in the lung tissues was investigated by immunohistochemistry. We investigated whether oxidative/nitrosative stress, which is a major cause of the pathogenesis in @entity1030 , could augment the production of @entity26004 . We examined the role of @entity26004 in the stress-mediated tissue remodeling responses. We also investigated the susceptibility of @entity26004 expression to nitrosative stress using bronchial fibroblasts isolated from the lung tissues. RESULTS: The expression of @entity26004 was up-regulated in the small airways and pulmonary vessels of the @entity1030 @entity1 and it was mainly expressed in bronchial fibroblasts and cells of the pulmonary vessels. The extent of the @entity26004 expression in the small airway of the @entity1030 group had a significant correlation with the severity of the airflow limitation. Oxidative/nitrosative stress augmented the production of @entity26004 in lung fibroblasts as well as the translocation of @entity26004 into the nuclei. Silencing of @entity26004 suppressed the stress-augmented differentiation into myofibroblasts, the release of collagens and metalloproteinases. Bronchial fibroblasts from the @entity1 with @entity1030 highly expressed @entity26004 compared to those from the control subjects under basal condition and were more susceptible to the induction of @entity26004 expression by nitrosative stress compared to those from the control subjects. CONCLUSION: We provide the first evidence that the expression of @entity26004 is up-regulated in small airways and pulmonary vessels of @entity1 with @entity1030 and may be involved in the tissue remodeling of @entity1030 .

title: Possible role of Kr  ppel-like factor 5 in the remodeling of small airways and pulmonary vessels in XXXX .

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']


abstract: BACKGROUND: To compare the prescription modalities of general practitioners (GPs) and rheumatologists (RHs) for symptomatic @entity626 ( @entity571 ) and to determine correlates with prescription of low-dose NSAIDs. METHODS: This observational, prospective, national survey was carried out among a national representative sample of GPs (n = 808) and RHs (n = 134). Each physician completed a medical questionnaire for the 2 most recent @entity1 fulfilling the ACR criteria for knee @entity571 . RESULTS: GPs and RHs included 1,570 and 251 @entity1 , respectively. Mean pain level of the knee (on a VAS, 0-100 mm) was greater for GP @entity1 than for RH @entity1 (49.8    16.3 vs. 46.2    17.1 mm, respectively; p < 0.01). As compared with @entity1 of RHs, those of GPs more frequently had another joint affected by @entity571 : 71.2% vs. 63.7% (p < 0.0001) and more often had @entity101 and @entity6 (p < 0.05). As compared with RHs, GPs more frequently prescribed low-dose NSAIDs (p < 0.0001), oral NSAIDs (p < 0.05), and topical NSAIDs (p < 0.0001) but less frequently symptomatic slow-acting drugs for @entity571 (p < 0.01). Moreover, GPs more frequently recommended rehabilitation (p < 0.01) and loss of weight (p < 0.0001). Logistic regression analysis revealed an association of low-dose NSAIDs prescription and prescription by GPs, prescription of topical NSAIDs, no prescription of oral NSAIDs or coxibs and no intra-articular injection of @entity230 . CONCLUSIONS: This study identified speciality-related variability in some aspects of the management of knee @entity571 . The clinical profile of @entity1 with knee @entity571 differed between GPs and RHs.

title: Comparison of general practitioners and rheumatologists' prescription patterns for @entity1 with XXXX .

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']


abstract: BACKGROUND: To compare the prescription modalities of general practitioners (GPs) and rheumatologists (RHs) for symptomatic @entity626 ( @entity571 ) and to determine correlates with prescription of low-dose NSAIDs. METHODS: This observational, prospective, national survey was carried out among a national representative sample of GPs (n = 808) and RHs (n = 134). Each physician completed a medical questionnaire for the 2 most recent @entity1 fulfilling the ACR criteria for knee @entity571 . RESULTS: GPs and RHs included 1,570 and 251 @entity1 , respectively. Mean pain level of the knee (on a VAS, 0-100 mm) was greater for GP @entity1 than for RH @entity1 (49.8    16.3 vs. 46.2    17.1 mm, respectively; p < 0.01). As compared with @entity1 of RHs, those of GPs more frequently had another joint affected by @entity571 : 71.2% vs. 63.7% (p < 0.0001) and more often had @entity101 and @entity6 (p < 0.05). As compared with RHs, GPs more frequently prescribed low-dose NSAIDs (p < 0.0001), oral NSAIDs (p < 0.05), and topical NSAIDs (p < 0.0001) but less frequently symptomatic slow-acting drugs for @entity571 (p < 0.01). Moreover, GPs more frequently recommended rehabilitation (p < 0.01) and loss of weight (p < 0.0001). Logistic regression analysis revealed an association of low-dose NSAIDs prescription and prescription by GPs, prescription of topical NSAIDs, no prescription of oral NSAIDs or coxibs and no intra-articular injection of @entity230 . CONCLUSIONS: This study identified speciality-related variability in some aspects of the management of knee @entity571 . The clinical profile of @entity1 with knee @entity571 differed between GPs and RHs.

title: Comparison of general practitioners and rheumatologists' prescription patterns for XXXX with @entity626 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To investigate the relationships between constitutional types of traditional Chinese medicine (TCM) and @entity11535 . METHODS: A survey of TCM @entity9528 in ocean sailors participating in a voyage was performed by using the TCM Constitution Questionnaire developed by Beijing University of Traditional Chinese Medicine, while the survey of @entity11535 was operated by Graybiel's diagnostic criteria. The incidences of @entity11535 among sailors with different types of @entity9528 were compared. RESULTS: Prior to the voyage, 50.3% of sailors exhibited a gentleness @entity9528 , 14.5% were of dampness-heat @entity9528 , 10.3% were of qi-stagnation @entity9528 , whereas the percentages of @entity942 , @entity14717 , @entity20247 , @entity1503 and special diathesis @entity9528 were 6.2%, 7.6%, 6.2%, 4.1% and 0.7%, respectively. None exhibited a phlegm-dampness @entity9528 . By the end of the 176-day voyage, the percentages of gentleness, @entity308 , @entity942 , @entity14717 , @entity20247 , @entity1503 , special diathesis and phlegm-dampness @entity9528 were 33.8%, 13.8%, 13.1%, 11.0%, 6.9%, 9.7%, 4.1%, 0.7% and 6.9%, respectively. The incidence of @entity11535 was 69.7% (101 sailors) during this voyage. The incidences of @entity11535 among sailors with different types of @entity9528 before the voyage showed significant difference (P<0.001). The incidence of @entity11535 was higher in the sailors with dampness-heat @entity9528 than in those with gentleness @entity9528 . CONCLUSION: Types of Chinese medical @entity9528 can be related to susceptibility to @entity11535 . Furthermore, ocean voyage may have an effect or influence on the type of Chinese medical @entity9528 of sailors involved.

title: [Relationships between constitutional types of traditional Chinese medicine and XXXX in 145 ocean sailors].

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['dampness-heat, qi-depression']

entities_list: @entity14717 :: ('MESH:D016711', 'Disease') :: ['yang-deficiency']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['blood-stasis']

entities_list: @entity11535 :: ('MESH:D009041', 'Disease') :: ['motion sickness']

entities_list: @entity9528 :: ('MESH:D005878', 'Disease') :: ['constitution', 'constitutions']

entities_list: @entity20247 :: ('MESH:D016710', 'Disease') :: ['yin-deficiency']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['qi-deficiency']

answer: @entity11535 :: (MESH:D009041,Disease) :: ['motion sickness']


abstract: The incidence of @entity364 is frequent among liver transplanted subjects. Between March 1986 and June 2009, we performed 670 liver transplants in 593 @entity1 , including 61% males and an overall average age of 46. The incidence of @entity455 in our center was 5.3% (32/593 @entity1 ), including 24 (75%) @entity715 , 5 (16%) @entity2849 , 2 anastomotic stenoses, and 1 an iliac graft rupture owing to a @entity5880 . Four @entity1 presented @entity455 associated with Aspergillus sp. Three of them were males of mean age 50 years and 3 had an acute rejection episode. Immunosuppression was @entity205 (CsA), @entity230 , and @entity500 . Four @entity455 were diagnosed: 2 @entity715 and 2 @entity397 . Two @entity1 presented biliary complications associated with the arterial complication and @entity281 . Treatment was expectant in 1 @entity1 , interventional radiology in an other, and retransplantation in the other 2. All @entity1 infected with Aspergillus sp. diad of @entity295 and @entity177 . Arterial complications posttransplant associated with @entity281 by Aspergillus sp., can be an important cause of retransplantation, @entity295 and @entity204 .

title: Influence of @entity281 by Aspergillus in XXXX after liver transplantation: evolution and results in 670 transplants.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5880 :: ('MESH:D000785', 'Disease') :: ['mycotic aneurysm']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['arterial complications']

entities_list: @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['multiorgan failure']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal complications']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['pseudoaneurysm ruptures']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'Aspergillus infection']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thromboses']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysms']

answer: @entity455 :: (MESH:D014652,Disease) :: ['arterial complications']


abstract: The incidence of @entity364 is frequent among liver transplanted subjects. Between March 1986 and June 2009, we performed 670 liver transplants in 593 @entity1 , including 61% males and an overall average age of 46. The incidence of @entity455 in our center was 5.3% (32/593 @entity1 ), including 24 (75%) @entity715 , 5 (16%) @entity2849 , 2 anastomotic stenoses, and 1 an iliac graft rupture owing to a @entity5880 . Four @entity1 presented @entity455 associated with Aspergillus sp. Three of them were males of mean age 50 years and 3 had an acute rejection episode. Immunosuppression was @entity205 (CsA), @entity230 , and @entity500 . Four @entity455 were diagnosed: 2 @entity715 and 2 @entity397 . Two @entity1 presented biliary complications associated with the arterial complication and @entity281 . Treatment was expectant in 1 @entity1 , interventional radiology in an other, and retransplantation in the other 2. All @entity1 infected with Aspergillus sp. diad of @entity295 and @entity177 . Arterial complications posttransplant associated with @entity281 by Aspergillus sp., can be an important cause of retransplantation, @entity295 and @entity204 .

title: Influence of XXXX by Aspergillus in @entity455 after liver transplantation: evolution and results in 670 transplants.

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infection']


abstract: AIM: Liver transplantation (OLT) has become the treatment of choice for end-stage @entity1578 , as well as for selected cases of @entity5 and @entity209 . @entity260 and mortality rates are expected to correlate with improvements in the interdisciplinary team approach, the perioperative anesthesiologic and intensive care management, and careful follow-up after transplantation. In this study, we have evaluated the effect of gained experience on @entity260 and mortality in cadaveric OLT performed in our institution. MATERIALS AND METHODS: Data from cadaveric OLT @entity1 (n = 34) since 2003 were retrospectively evaluated. @entity1 were divided into 2 groups: Early (2003-2006; n = 15) and late (2007-2010; n = 19). Age, gender, cold and warm @entity63 times, intraoperative transfusion rates, @entity166 , @entity455 rates, and early and late postoperative mortality rates were compared in the 2 groups. RESULTS: The age and gender distribution was similar among both groups. Mean cold and warm @entity63 times, intraoperative transfusion rates, and operative times were significantly lower in the late period group (P = .004, .012, and 0.008, respectively; CI=%95). T-tube usage was also significantly lower in the late period group (P < .001). There was no significant change for postoperative intensive care period (P = .404), but the overall length of stay in hospital was shorter for the @entity1 in the late period group (P = .019). The nonsurgical early @entity260 rate was lower (P = .001) and early postoperative mortality was nearly significant (P = .06) in @entity1 who comprised the late period group. There was no difference in terms of @entity455 rates and overall survival rates between @entity1 in the early and late groups (P = .664, .264, and .107, respectively). CONCLUSION: Our results indicate that the institutional improvements toward an interdisciplinary team approach in cadaveric OLT correlate with better results in @entity63 and operative times and lower intraoperative transfusion rates and hospital stays. Early @entity260 and mortality rates were found to decline in parallel to the team experience.

title: The effect of gained experience on XXXX and mortality in cadaveric liver transplantation: a single-center experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['biliary and vascular complication']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications', 'Decreased postoperative complications', 'postoperative complication']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious complications']

answer: @entity260 :: (MESH:D011183,Disease) :: ['postoperative complications']


abstract: UNASSIGNED: @entity25 ( @entity25 ) is a prevalent symptom among @entity64 survivors. This symptom is an independent risk factor for @entity64 and may reduce @entity64 survivors' quality of life, cognitive functioning, and daytime functional performance. The lack of a universally accepted definition of @entity25 makes it difficult to measure @entity25 and synthesize research. The purpose of this integrative review is to describe @entity25 , ascertain conceptual and operational definitions of @entity25 , identify factors that contribute to @entity25 in @entity64 survivors, and explore outcomes associated with @entity25 in @entity64 survivors. We searched the following databases: PubMed and MEDLINE (OvidSP 1946-April; Week 2, 2015), Embase (OvidSP 1974-March; Week 1, 2015), and PsycINFO (OvidSP 1967-April; Week 2, 2015). Our search yielded 340 articles, 27 of which met inclusion criteria. The literature reveals @entity25 to be a multidimensional construct that is operationalized with both subjective and objective measures. Choosing measures that can quantify both the objective and subjective components is useful for gaining a comprehensive understanding of @entity25 . The antecedents of @entity25 are @entity64 , @entity387 , reversed @entity5599 , and @entity308 . The outcomes associated with @entity25 in @entity64 @entity1 are serious and negative. Via synthesis of this research, we propose a possible framework for @entity25 , which may be of use in clinical practice and in research to identify valid quantifying methods for @entity25 as well as to prevent harmful outcomes in @entity64 survivors.

title: Excessive Daytime Sleepiness in XXXX Survivors: An Integrative Review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep-disordered breathing']

entities_list: @entity5599 :: ('MESH:D010855', 'Disease') :: ['Robin Hood syndrome']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['Excessive daytime sleepiness', 'EDS', 'poststroke EDS']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: OBJECTIVES: @entity884 of the aortic valve with local aortic root destruction requires radical resection of infected tissues and subsequent reconstruction of periannular structures and the left ventricular outflow tract (LVOT). Homografts or stentless bioprostheses are recommended for use in this specific @entity1 group. The Freestyle stentless bioprosthesis is a porcine aortic root prosthesis, which approaches the surgical versatility of the homograft, but has the advantage of ready availability and uniform quality. We assessed clinical and echocardiographic outcome following the use of this prosthesis in extensive @entity886 . METHODS: Between June 2000 and December 2014, 55 Freestyle prostheses were implanted for @entity886 involving the root in 54 @entity1 (74% male). The mean age at operation was 61    13 years. The mean EuroSCORE II was 20.1    13.5. Twenty-nine (54%) @entity1 had @entity340 . The median follow-up time after surgery was 3.5 years, ranging from 0 to 15 years. RESULTS: Early and late mortality were 11% (6 @entity1 ) and 14% (7 @entity1 ), respectively. Estimated overall survival at 1 and 5 years was 83 and 70%, respectively. There was no survival difference between @entity1 with native or @entity340 . One @entity1 underwent reoperation for recurrent @entity884 2.3 years after the initial procedure. No other prosthesis failure occurred. At a median follow-up of 3.3 years, mean gradient over the prosthesis was 4.3    2.3 mmHg. No @entity1 had more than mild @entity337 . CONCLUSIONS: The Freestyle stentless bioprosthesis is a valuable option to reconstruct the LVOT after debridement in extensive @entity886 . It is readily available with a versatility and clinical outcome comparable with that of homografts. Although early mortality remains considerable in this high-risk group of @entity1 , late survival is good with low rates of recurrence of @entity884 , immediate local control and good haemodynamic performance on echocardiography.

title: Stentless bioprostheses: a versatile and durable solution in extensive XXXX   .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['aortic valve endocarditis']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['prosthetic valve endocarditis']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['Infective endocarditis', 'endocarditis']

answer: @entity886 :: (MESH:C563178,Disease) :: ['aortic valve endocarditis']


abstract: @entity137 is defined as response to a drug which is noxious and unintended, and which occurs at doses normally used in @entity1 for the prophylaxis, diagnosis or therapy of disease, or for the modification of physiological functions. @entity56 is known as anaphylactic reaction which is due to immediate immunoglobulin E-mediated reaction. It is characterized by symptoms such as fever @entity390 , back @entity158 , angiodema, @entity1910 , @entity1671 , etc. Lepa generally refers to the application of pastes formed by mixing powder of herbs with water, milk, etc., and liquids. Complementary and alternative medicines are frequently used by the general population. Many @entity1 consider them to be without side effects. Ayurvedic treatment involves Shodhana (biopurification), Shaman (pacification), Bahya (external therapy), and Abhyantara karma's (internal therapy) for treating @entity66 . One such bahya karma or external therapy is lepa. Even though lepa is said as "Aadhya Upakrama," undue @entity56 is observed in many @entity1 . A 60-year-old @entity1 had an adverse reaction to lepa after being administered as an external medication. The observations were erythema, eruptions, and itching. Such case of @entity56 is discussed in the present study.

title: XXXX as a complication of lepa.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'woman', 'man', 'people']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Adverse drug reaction']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['different diseases']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['Type I hypersensitivity reaction', 'hypersensitivity']

answer: @entity56 :: (MESH:D004342,Disease) :: ['Type I hypersensitivity reaction']


abstract: AIM OF THE STUDY: To analyse the incidence of @entity2466 in appendectomy specimens and establish the epidemiological and histopathological features, treatment, and clinical course. MATERIAL AND METHODS: Between 2004 and 2013, 975 @entity1 who underwent appendectomy in Ankara Oncology Education and Research Hospital were retrospectively analysed. RESULTS: @entity5 was detected in the nine of 975 (0.9%) @entity1 . Neuroendocrine @entity5 were diagnosed in eight @entity1 by appendectomy, which was performed because of the prediagnosis of @entity697 , and in one @entity1 by the suspicious mass detection during surgical procedures that were done in the appendix for a different reason. Eight of the @entity1 ' @entity5 were in the tip of the appendix, and one of the @entity1 ' @entity5 was at the base of appendix. @entity5 size in 77.8% of @entity1 was equal or less than 1 cm, in 22.2% @entity1 it was 1-2 cm. There was @entity5 invasion in the muscularis propria layer in four @entity1 , in the serosa layer in three @entity1 , and in the deep mesoappendix in two @entity1 . @entity1 were followed for a median of 78 months. In the follow-up of @entity1 who were operated because of @entity694 , metachronous @entity5 evolved. This @entity1 died due to progressive disease. Other @entity1 are still disease-free. CONCLUSIONS: The diagnosis of @entity5 is often incidentally done after appendectomy. @entity5 size is important in determining the extent of disease and in the selection of the surgical method during operation.

title: Clinical experience XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute appendicitis']

entities_list: @entity2466 :: ('MESH:D001063', 'Disease') :: ['appendiceal neuroendocrine neoplasms']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Neuroendocrine neoplasm', 'neuroendocrine neoplasm', 'Tumour', 'tumours', 'colon tumour', 'neoplasms', 'tumour']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity2466 :: (MESH:D001063,Disease) :: ['in appendiceal neuroendocrine neoplasms']


abstract: Transcranial magnetic stimulation (TMS) gives rise to muscle responses, known as motor evoked potentials (MEP), through activation of the motor pathways. Voluntary contraction causes facilitation of MEPs, which consists of shortening MEP latency, increasing MEP amplitude and widening MEP duration. While an increase in excitability of alpha motorneurons and the corticospinal tract can easily explain latency shortening and amplitude increase, other mechanisms have to be accounted for to explain the increase in duration. We measured the increase in duration of the MEP during contraction with respect to rest in a group of healthy volunteers and retrospectively assessed this parameter in @entity1 who were examined in a standardized fashion during the past 5 years. We included 25 healthy subjects, 21 @entity1 with @entity15 , 33 @entity1 with @entity64 , 5 @entity1 with @entity3500 , and 5 @entity1 with signs suggesting @entity3520 paresis. We found already significant differences among groups in the MEP duration at rest, @entity1 with @entity15 had a significantly longer duration, and @entity1 with @entity64 had significantly shorter duration, than the other two groups. The increase in MEP duration during @entity2472 was different in @entity1 and in healthy subjects. It was significantly shorter in @entity15 and significantly longer in @entity64 @entity1 . It was absent in the five @entity1 with suspected @entity425 . In @entity1 with HSP, an abnormally increase in duration occurred only in leg muscles. Our results suggest that the increase in duration of the MEP during contraction may reveal the contribution of propriospinal interneurons to the activation of alpha motorneurons. This mechanism may be altered in some diseases and, therefore, the assessment proposed in this work may have clinical applicability for the differential diagnosis of @entity425 .

title: Clinical Value of the Assessment of Changes in MEP Duration with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'acute stroke']

entities_list: @entity3520 :: ('MESH:D020821', 'Disease') :: ['psychogenic']

entities_list: @entity3500 :: ('MESH:D020336', 'Disease') :: ['hereditary spastic paraparesis']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['psychogenic weakness', 'weakness']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['MS', 'multiple sclerosis']

entities_list: @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary contraction']

answer: @entity2472 :: (MESH:C536214,Disease) :: ['Voluntary Contraction']


abstract: Healthy sleep is essential in @entity1 's cognitive, behavioral, and emotional development. However, remarkably little is known about the influence of @entity25 on different memory processes in childhood. Such data could give us a deeper insight into the effect of sleep on the developing brain and memory functions and how the relationship between sleep and memory changes from childhood to adulthood. In the present study we examined the effect of @entity25 on declarative and non-declarative memory consolidation by testing @entity1 with @entity387 ( @entity387 ) which is characterized by disrupted sleep structure. We used a story recall task to measure declarative memory and Alternating Serial Reaction time (ASRT) task to assess non-declarative memory. This task enables us to measure two aspects of non-declarative memory, namely general motor skill learning and sequence-specific learning. There were two sessions: a learning phase and a testing phase, separated by a 12 h offline period with sleep. Our data showed that @entity1 with @entity387 exhibited a generally lower declarative memory performance both in the learning and testing phase; however, both the @entity387 and control groups exhibited retention of the previously recalled items after the offline period. Here we showed intact non-declarative consolidation in @entity387 group in both sequence-specific and general motor skill. These findings suggest that @entity25 in childhood have a differential effect on different memory processes (online vs. offline) and give us insight into how @entity25 affects developing brain.

title: Declarative and Non-declarative Memory Consolidation in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disorders', 'sleep disturbances', 'sleep disorder']

entities_list: @entity387 :: ('MESH:D012891', 'Disease') :: ['sleep-disordered breathing', 'SDB']

answer: @entity25 :: (MESH:D012893,Disease) :: ['Sleep Disorder']


abstract: Healthy sleep is essential in @entity1 's cognitive, behavioral, and emotional development. However, remarkably little is known about the influence of @entity25 on different memory processes in childhood. Such data could give us a deeper insight into the effect of sleep on the developing brain and memory functions and how the relationship between sleep and memory changes from childhood to adulthood. In the present study we examined the effect of @entity25 on declarative and non-declarative memory consolidation by testing @entity1 with @entity387 ( @entity387 ) which is characterized by disrupted sleep structure. We used a story recall task to measure declarative memory and Alternating Serial Reaction time (ASRT) task to assess non-declarative memory. This task enables us to measure two aspects of non-declarative memory, namely general motor skill learning and sequence-specific learning. There were two sessions: a learning phase and a testing phase, separated by a 12 h offline period with sleep. Our data showed that @entity1 with @entity387 exhibited a generally lower declarative memory performance both in the learning and testing phase; however, both the @entity387 and control groups exhibited retention of the previously recalled items after the offline period. Here we showed intact non-declarative consolidation in @entity387 group in both sequence-specific and general motor skill. These findings suggest that @entity25 in childhood have a differential effect on different memory processes (online vs. offline) and give us insight into how @entity25 affects developing brain.

title: Declarative and Non-declarative Memory Consolidation in XXXX with @entity25 .

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: BACKGROUND: The aim of the present study was to assess the mid-term patency rate of @entity5648 stent implantation in @entity1 with long superficial femoral artery (SFA) @entity850 or @entity432 . This is a retrospective, single-center study. METHODS: The data of 138 @entity1 were retrospectively assessed in our center to determine the patency rate after @entity5648 stenting of the SFA. MATERIALS: Data for 165 limbs from 138 @entity1 were collected. Each limb showed a long lesion with a total @entity432 of >10 cm and mean lesion length of 20.35    9.46 cm (range, 10-32 cm). @entity5648 self-expanding stent implantations were performed in each limb. A total of 258 stents were implanted into 165 limbs (average, 1.56 stents/limb). Each @entity1 received clinical and ultrasound/computerized tomographic angiography/magnetic resonance angiography evaluations before the procedure and underwent clinical status evaluation and an ankle-brachial index test at discharge and at 12, 24, and 36 months thereafter. RESULTS: The initial technical success rate of revascularization was 91.51% (151/163). During follow-up, nine @entity1 died because of @entity583 , @entity385 , and @entity55 , and 14 @entity1 were lost to follow-up. The mean follow-up period for 150 limbs from 124 @entity1 was 25.46 months (range, 6-51). During follow-up, 19 in-stent restenoses and 15  occlusions were diagnosed. In all, 30 re-interventions were performed, including six balloon angioplasties, three secondary cutting balloon angioplasties, 10 restenting procedures, four bypass surgeries, two bone marrow stem cell transplantations, and five limb amputations. Analysis showed the primary patency rates at 12, 24, and 36 months were 92.4%, 78.3%, and 62.1%, respectively, and the overall assisted-primary patency rates were 94.4%, 84.6%, and 75.8%, respectively. CONCLUSIONS: @entity5648 self-expanding stent implantation seems to be a good choice for older @entity1 with long SFA occlusions. Although the short- and mid-term patency results were good, more observations are needed to assess its long-term efficiency.

title: Endovascular XXXX stenting for long occlusive disease of the superficial femoral artery in critical limb ischemia: a single-center, mid-term result.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusion']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity5648 :: ('MESH:C013616', 'Chemical') :: ['Nitinol', 'nitinol']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity5648 :: (MESH:C013616,Chemical) :: ['nitinol']


abstract: Midline catheters have many advantages for chronically ill @entity1 needing up to six weeks intravenous therapy and medications, and when inserted in a sterile environment and correctly monitored and maintained, have a significantly lower association of infection and @entity715 than previously suggested. Furthermore, there is a reduction in central collateral vessel formation from incursions into the superior vena cava, associated with peripherally inserted central catheters. Midline use was examined in a @entity1577 control group. Lines were checked daily until removal. All midline catheter tips were sent for culture on removal and data from 42 midlines placed in 2006 were retrieved from the hospital scientist for analysis. Twenty-seven inpatients with @entity1577 were identified and informed of the trial and possible risks of midline use. Outcome variables included infection and @entity715 rates. On conclusion of the trial, data demonstrated both zero infection and @entity715 rates in the study @entity1 population. Midline catheters were monitored for a further 12 months following conclusion of the trial and infection rates continued to be below 1% and @entity715 rates lower than 2%. In the specified group, the parameters of use for midlines fit with international @entity1577 intravenous antibiotic protocols currently adhered to. The study has begun to generate evidence to inform clinical practice, improve @entity1 outcomes and supports the role of the specialist nurse in implementing midlines for @entity1577 @entity1 .

title: Improving antibiotic treatment outcomes through the implementation of a midline: piloting a change in practice for XXXX @entity1 .

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']

answer: @entity1577 :: (MESH:D003550,Disease) :: ['cystic fibrosis']


abstract: Midline catheters have many advantages for chronically ill @entity1 needing up to six weeks intravenous therapy and medications, and when inserted in a sterile environment and correctly monitored and maintained, have a significantly lower association of infection and @entity715 than previously suggested. Furthermore, there is a reduction in central collateral vessel formation from incursions into the superior vena cava, associated with peripherally inserted central catheters. Midline use was examined in a @entity1577 control group. Lines were checked daily until removal. All midline catheter tips were sent for culture on removal and data from 42 midlines placed in 2006 were retrieved from the hospital scientist for analysis. Twenty-seven inpatients with @entity1577 were identified and informed of the trial and possible risks of midline use. Outcome variables included infection and @entity715 rates. On conclusion of the trial, data demonstrated both zero infection and @entity715 rates in the study @entity1 population. Midline catheters were monitored for a further 12 months following conclusion of the trial and infection rates continued to be below 1% and @entity715 rates lower than 2%. In the specified group, the parameters of use for midlines fit with international @entity1577 intravenous antibiotic protocols currently adhered to. The study has begun to generate evidence to inform clinical practice, improve @entity1 outcomes and supports the role of the specialist nurse in implementing midlines for @entity1577 @entity1 .

title: Improving antibiotic treatment outcomes through the implementation of a midline: piloting a change in practice for @entity1577 XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Cell type specific radial positioning of chromosome territories (CTs) and their sub-domains in the interphase seem to have functional relevance in non-neoplastic @entity1 nuclei, while much less is known about nuclear architecture in @entity189 cells and its development during @entity5 progression. We analyzed the 3D-architecture of the chromosome 8 territory ( @entity53957 ) in @entity189 and corresponding non-neoplastic ductal pancreatic epithelium. Fluorescence-in-situ-hybridization (FISH) with whole chromosome painting (WCP) probes on sections from @entity406 -fixed, paraffin wax-embedded tissues from six @entity1 with @entity1124 was used. Radial positions and shape parameters of @entity53957 were analyzed by 3D-microscopy. None of the parameters showed significant inter-individual changes. @entity53957 was localized in the nuclear periphery in @entity189 cells and normal ductal epithelial cells. Normalized volume and surface of @entity53957 did not differ significantly. In contrast, the normalized roundness was significantly lower in @entity189 cells, implying an elongation of neoplastic cell nuclei. Unexpectedly, radial positioning of @entity53957 , a dominant parameter of nuclear architecture, did not change significantly when comparing neoplastic with non-neoplastic cells. A significant deformation of @entity53957 , however, accompanies nuclear atypia of @entity189 cells. This decreased roundness of CTs may reflect the genomic and transcriptional alterations in @entity189 .

title: Nuclear position and shape deformation of chromosome 8 territories in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1124 :: ('MESH:D021441', 'Disease') :: ['ductal adenocarcinoma of the pancreas']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

answer: @entity1124 :: (MESH:D021441,Disease) :: ['pancreatic ductal adenocarcinoma']


abstract: The left internal thoracic artery (LITA) is the conduit of choice for coronary artery bypass (CABG) due to favorable long-term patency. Uncommonly, diffuse narrowing like a string without significant @entity850 of an @entity254 is observed in the LITA graft (called "string sign"). Isolated left main trunk (LMT) diseases were reported to regress in some cases. However, the relationship between "string sign" and the regression of solitary LMT disease remains unknown.We retrospectively studied 40 consecutive @entity1 with isolated @entity850 who underwent CABG using LITA and who underwent angiography before and after operation (31 males, 9 females, mean age, 65.0 years). The @entity1 were divided into 2 groups according to the postoperative angiographic outcomes of the LITA graft: one group included @entity1 with "string sign" (6 @entity1 ), the other group consisted of @entity1 with a patent LITA graft (34 @entity1 ).There were no significant differences in clinical backgrounds between the two groups. The 2 groups showed similar quantitative % @entity3979 of the LMT before operation (77.5% versus 76.8%) and the observation period was similar in both groups. Coronary angiography after CABG revealed that % @entity850 of the LMT in @entity1 with "string sign" was significantly less than that in @entity1 with a patent LITA graft (41.7    26% versus 82.5    11%, P < 0.001). Regression in LMT was significantly more frequently observed in the "string sign group". Furthermore, ostial @entity850 was more frequent in @entity1 with "string sign". "String phenomenon" of the LITA graft is one of the signs related to the regression of @entity850 , and especially in ostial @entity850 of the LMT.

title: String-sign in left internal thoracic artery is associated with regression in left main XXXX after coronary artery bypass.

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['LMT stenosis', 'stenosis']

entities_list: @entity3979 :: ('MESH:D023921', 'Disease') :: ['coronary artery stenosis']

answer: @entity850 :: (MESH:D003251,Disease) :: ['trunk stenosis']


abstract: OBJECTIVES: Although increased reactive @entity26 species (ROS) is caused by stress accelerates collagen degradation, there was no data on the relationship between stress and urinary @entity720 ( @entity19487 ) and @entity1521 (Pro), a good marker of collagen degradation. The purpose of this study was to evaluate the relationship between @entity308 , @entity148 , and stress (DAS) and concentrations of urinary @entity19487 and Pro. METHODS: 97 hospital employees aged 20 to 58 were asked to fill out comprehensive self-administrated questionnaires containing information about their medical history, lifestyle, length of the work year, shift-work and DAS. @entity308 @entity148 stress scale (DASS) was applied to evaluate chronic @entity146 . Urine samples were analyzed using high performance liquid chromatography (HPLC) with double derivatization for the assay of @entity720 and @entity1521 . RESULTS: The mean value of @entity19487 and Pro concentration in all subjects was 194.1    113.4  mol/g and 568.2    310.7  mol/g. DASS values and urinary Pro concentrations were differentiated by sex (female > male, p < 0.05) and type of job (nurse > others, p < 0.05). In the stepwise multiple linear regressions, urinary @entity19487 and Pro concentrations were influenced by stress (Adjusted r2 = 0.051) and @entity148 and job (Adjusted r2 = 0.199), respectively. CONCLUSIONS: We found that stress and @entity148 were correlated with urinary @entity19487 and Pro concentrations. To identifying a definite correlation, further study in large populations will be needed.

title: Relationship between @entity308 @entity148 stress scale (DASS) and urinary XXXX and @entity1521 concentrations in hospital workers.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity720 :: ('CHEBI:18095', 'Chemical') :: ['hydroxyproline']

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

answer: @entity720 :: (CHEBI:18095,Chemical) :: ['hydroxyproline']


abstract: OBJECTIVES: Although increased reactive @entity26 species (ROS) is caused by stress accelerates collagen degradation, there was no data on the relationship between stress and urinary @entity720 ( @entity19487 ) and @entity1521 (Pro), a good marker of collagen degradation. The purpose of this study was to evaluate the relationship between @entity308 , @entity148 , and stress (DAS) and concentrations of urinary @entity19487 and Pro. METHODS: 97 hospital employees aged 20 to 58 were asked to fill out comprehensive self-administrated questionnaires containing information about their medical history, lifestyle, length of the work year, shift-work and DAS. @entity308 @entity148 stress scale (DASS) was applied to evaluate chronic @entity146 . Urine samples were analyzed using high performance liquid chromatography (HPLC) with double derivatization for the assay of @entity720 and @entity1521 . RESULTS: The mean value of @entity19487 and Pro concentration in all subjects was 194.1    113.4  mol/g and 568.2    310.7  mol/g. DASS values and urinary Pro concentrations were differentiated by sex (female > male, p < 0.05) and type of job (nurse > others, p < 0.05). In the stepwise multiple linear regressions, urinary @entity19487 and Pro concentrations were influenced by stress (Adjusted r2 = 0.051) and @entity148 and job (Adjusted r2 = 0.199), respectively. CONCLUSIONS: We found that stress and @entity148 were correlated with urinary @entity19487 and Pro concentrations. To identifying a definite correlation, further study in large populations will be needed.

title: Relationship between XXXX @entity148 stress scale (DASS) and urinary @entity720 and @entity1521 concentrations in hospital workers.

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: OBJECTIVES: Although increased reactive @entity26 species (ROS) is caused by stress accelerates collagen degradation, there was no data on the relationship between stress and urinary @entity720 ( @entity19487 ) and @entity1521 (Pro), a good marker of collagen degradation. The purpose of this study was to evaluate the relationship between @entity308 , @entity148 , and stress (DAS) and concentrations of urinary @entity19487 and Pro. METHODS: 97 hospital employees aged 20 to 58 were asked to fill out comprehensive self-administrated questionnaires containing information about their medical history, lifestyle, length of the work year, shift-work and DAS. @entity308 @entity148 stress scale (DASS) was applied to evaluate chronic @entity146 . Urine samples were analyzed using high performance liquid chromatography (HPLC) with double derivatization for the assay of @entity720 and @entity1521 . RESULTS: The mean value of @entity19487 and Pro concentration in all subjects was 194.1    113.4  mol/g and 568.2    310.7  mol/g. DASS values and urinary Pro concentrations were differentiated by sex (female > male, p < 0.05) and type of job (nurse > others, p < 0.05). In the stepwise multiple linear regressions, urinary @entity19487 and Pro concentrations were influenced by stress (Adjusted r2 = 0.051) and @entity148 and job (Adjusted r2 = 0.199), respectively. CONCLUSIONS: We found that stress and @entity148 were correlated with urinary @entity19487 and Pro concentrations. To identifying a definite correlation, further study in large populations will be needed.

title: Relationship between @entity308 @entity148 stress scale (DASS) and urinary @entity720 and XXXX concentrations in hospital workers.

answer: @entity1521 :: (CHEBI:26271,Chemical) :: ['proline']


abstract: OBJECTIVES: Although increased reactive @entity26 species (ROS) is caused by stress accelerates collagen degradation, there was no data on the relationship between stress and urinary @entity720 ( @entity19487 ) and @entity1521 (Pro), a good marker of collagen degradation. The purpose of this study was to evaluate the relationship between @entity308 , @entity148 , and stress (DAS) and concentrations of urinary @entity19487 and Pro. METHODS: 97 hospital employees aged 20 to 58 were asked to fill out comprehensive self-administrated questionnaires containing information about their medical history, lifestyle, length of the work year, shift-work and DAS. @entity308 @entity148 stress scale (DASS) was applied to evaluate chronic @entity146 . Urine samples were analyzed using high performance liquid chromatography (HPLC) with double derivatization for the assay of @entity720 and @entity1521 . RESULTS: The mean value of @entity19487 and Pro concentration in all subjects was 194.1    113.4  mol/g and 568.2    310.7  mol/g. DASS values and urinary Pro concentrations were differentiated by sex (female > male, p < 0.05) and type of job (nurse > others, p < 0.05). In the stepwise multiple linear regressions, urinary @entity19487 and Pro concentrations were influenced by stress (Adjusted r2 = 0.051) and @entity148 and job (Adjusted r2 = 0.199), respectively. CONCLUSIONS: We found that stress and @entity148 were correlated with urinary @entity19487 and Pro concentrations. To identifying a definite correlation, further study in large populations will be needed.

title: Relationship between @entity308 XXXX stress scale (DASS) and urinary @entity720 and @entity1521 concentrations in hospital workers.

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: PURPOSE OF REVIEW: This paper reviews the recent literature regarding the effectiveness, efficacy and safety of intravitreal bevacizumab as compared with ranibizumab for the treatment of neovascular age-related @entity1020 (nAMD). RECENT FINDINGS: Numerous randomized clinical trials have demonstrated the safety and efficacy of ranibizumab for the treatment of nAMD. Bevacizumab, developed, labeled and approved for the management of @entity14 , has been used off-label for the management of nAMD. However, given its lower cost and effectiveness, it is commonly used for many cases of nAMD. Recent clinical trials have demonstrated similar effectiveness between the two compounds in terms of visual acuity and central macular thickness. However, emerging data have suggested that these two compounds may have different ocular and systemic adverse event profiles; bevacizumab has been linked to both a higher risk of @entity32 and a higher risk of incident arterial @entity1031 events. This incremental risk for both ocular and systemic adverse events may have an impact on the incremental cost-effectiveness ratio derived from health economic models that directly compare one @entity7 ( @entity7 ) compound to the other. SUMMARY: Numerous clinical trials, including the Comparison of @entity13785 Treatment Trial, are underway examining the comparative efficacy of ranibizumab versus bevacizumab for the treatment of nAMD. While these studies may demonstrate clinical noninferiority of one anti- @entity7 compound over another, they may not be adequately powered to detect important differences in ocular and systemic safety. Large-scale, appropriately powered safety studies need to be conducted to evaluate differences in safety.

title: Ranibizumab versus bevacizumab for the treatment of neovascular age-related XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['severe intraocular inflammation']

entities_list: @entity7 :: ('7422', 'Gene') :: ['VEGF', 'anti-vascular endothelial growth factor']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration']

answer: @entity1020 :: (MESH:D008268,Disease) :: ['macular degeneration']


abstract: BACKGROUND: Many @entity1 with an @entity3271 ( @entity3271 ) experience @entity410 , some of which become refractory to @entity302 ( @entity302 ). This study aims (1) to quantify the rate of @entity410 and medically @entity302 in @entity1 with ODs; and (2) to determine if there is any association between short-term and long-term survival, and the presence and drug-responsiveness of @entity410 . METHODS: A retrospective review was conducted of the medical records of @entity1 who had been pathologically identified as having an @entity3271 at the London Health Sciences Centre or the London Regional Cancer Program in London, Ontario from January 1996 to July 2008. Deaths were ascertained by reviewing all hospital records. Survival analysis was performed. RESULTS: One-hundred sixty-six @entity1 met inclusion criteria. @entity302 were the presenting feature or occurred as part of the initial manifestation of the @entity3271 in 75.3% of @entity1 , with 90.4% (n=150) experiencing at least one @entity410 and 76.5% developing @entity302 over the course of observation. Of the 150 @entity1 with @entity410 , 23 experienced a single @entity410 (13.9% of the 166), whereas 127 @entity1 experienced multiple @entity410 (76.5%). In those with multiple @entity410 , the @entity302 was refractory to drug treatment slightly more than half the time (54.3%). Survival analysis demonstrated consistently superior survival among those with a single @entity410 . Those without @entity410 had the worst survival rates over the first few years post-diagnosis; but then no further @entity204 occurred. Survival among those with refractory @entity410 tended to be better than among those whose @entity410 were drug responsive, over the first 10 years post-diagnosis. CONCLUSIONS: @entity410 are common and may influence survival in @entity1 with oligodendogliomas. Those who experience just one @entity410 appear to do best.

title: Do XXXX predict outcome in @entity1 with @entity3271 ?

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'Seizures', 'seizures']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['refractory epilepsy', 'Epileptic seizures', 'epilepsy', 'anti-epileptic drugs', 'AEDs']

entities_list: @entity3271 :: ('MESH:D009837', 'Disease') :: ['OD', 'oligodendroglioma']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epileptic seizures']


abstract: BACKGROUND: Many @entity1 with an @entity3271 ( @entity3271 ) experience @entity410 , some of which become refractory to @entity302 ( @entity302 ). This study aims (1) to quantify the rate of @entity410 and medically @entity302 in @entity1 with ODs; and (2) to determine if there is any association between short-term and long-term survival, and the presence and drug-responsiveness of @entity410 . METHODS: A retrospective review was conducted of the medical records of @entity1 who had been pathologically identified as having an @entity3271 at the London Health Sciences Centre or the London Regional Cancer Program in London, Ontario from January 1996 to July 2008. Deaths were ascertained by reviewing all hospital records. Survival analysis was performed. RESULTS: One-hundred sixty-six @entity1 met inclusion criteria. @entity302 were the presenting feature or occurred as part of the initial manifestation of the @entity3271 in 75.3% of @entity1 , with 90.4% (n=150) experiencing at least one @entity410 and 76.5% developing @entity302 over the course of observation. Of the 150 @entity1 with @entity410 , 23 experienced a single @entity410 (13.9% of the 166), whereas 127 @entity1 experienced multiple @entity410 (76.5%). In those with multiple @entity410 , the @entity302 was refractory to drug treatment slightly more than half the time (54.3%). Survival analysis demonstrated consistently superior survival among those with a single @entity410 . Those without @entity410 had the worst survival rates over the first few years post-diagnosis; but then no further @entity204 occurred. Survival among those with refractory @entity410 tended to be better than among those whose @entity410 were drug responsive, over the first 10 years post-diagnosis. CONCLUSIONS: @entity410 are common and may influence survival in @entity1 with oligodendogliomas. Those who experience just one @entity410 appear to do best.

title: Do @entity302 predict outcome in @entity1 with XXXX ?

answer: @entity3271 :: (MESH:D009837,Disease) :: ['oligodendroglioma']


abstract: BACKGROUND: Many @entity1 with an @entity3271 ( @entity3271 ) experience @entity410 , some of which become refractory to @entity302 ( @entity302 ). This study aims (1) to quantify the rate of @entity410 and medically @entity302 in @entity1 with ODs; and (2) to determine if there is any association between short-term and long-term survival, and the presence and drug-responsiveness of @entity410 . METHODS: A retrospective review was conducted of the medical records of @entity1 who had been pathologically identified as having an @entity3271 at the London Health Sciences Centre or the London Regional Cancer Program in London, Ontario from January 1996 to July 2008. Deaths were ascertained by reviewing all hospital records. Survival analysis was performed. RESULTS: One-hundred sixty-six @entity1 met inclusion criteria. @entity302 were the presenting feature or occurred as part of the initial manifestation of the @entity3271 in 75.3% of @entity1 , with 90.4% (n=150) experiencing at least one @entity410 and 76.5% developing @entity302 over the course of observation. Of the 150 @entity1 with @entity410 , 23 experienced a single @entity410 (13.9% of the 166), whereas 127 @entity1 experienced multiple @entity410 (76.5%). In those with multiple @entity410 , the @entity302 was refractory to drug treatment slightly more than half the time (54.3%). Survival analysis demonstrated consistently superior survival among those with a single @entity410 . Those without @entity410 had the worst survival rates over the first few years post-diagnosis; but then no further @entity204 occurred. Survival among those with refractory @entity410 tended to be better than among those whose @entity410 were drug responsive, over the first 10 years post-diagnosis. CONCLUSIONS: @entity410 are common and may influence survival in @entity1 with oligodendogliomas. Those who experience just one @entity410 appear to do best.

title: Do @entity302 predict outcome in XXXX with @entity3271 ?

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: The incidence of @entity788 has increased in China in the last decade, though efforts have been made in early detection and multimodality treatment. The aim of this study is to describe the decade-based development in early diagnosis and treatment modalities, as well as outcome for @entity1 with @entity1124 ( @entity1124 ) in a high-volume facility. METHODS: All the @entity1124 @entity1 underwent surgery between 1991 and 2009 and were selected from the database of TianJin @entity5 Institute and Hospital. Decade-based changes in early diagnosis, treatment modalities, and outcome of the @entity1 were retrospectively analyzed. RESULTS: Of the 565 @entity1 with @entity1124 , @entity1 in this decade (n   =   460) had better overall survival than those in the last decade (n   =   105), median survival was 10 months and 3 months, respectively. @entity1 in this decade had significantly improved in (P   <   0.001) 2-year (14.7%) and 5-year survival rates (3.5%) as compared to those in the last decade (6.7% and 3.4%, respectively). @entity1 with @entity3 at diagnosis in the last decade and this decade were 54% and 26% (P   <   0.001), respectively. More @entity1 in this decade had underwent R0/R1 resection (33% vs 20%, P   =   0.010), chemotherapy (37% vs 12%, P   <   0.001), and radical resection (34% vs 21%, P   =   0.014) than those in the last decade. CONCLUSION: @entity1 operated on for @entity1124 in this decade had a better outcome than those in the last decade. Early detection, improved resection margin, and development in multimodality treatment contribute to this improvement.

title: Improvement in treatment and outcome of XXXX in north China.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']

entities_list: @entity1124 :: ('MESH:D021441', 'Disease') :: ['PDAC', 'pancreatic ductal adenocarcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1124 :: (MESH:D021441,Disease) :: ['pancreatic ductal adenocarcinoma']


abstract: @entity1118 is a hallmark of @entity571 ( @entity571 ), yet little is known about its properties and representation in the brain. Here we use fMRI combined with psychophysics to study knee @entity158 in fourteen @entity571 @entity1 and nine healthy controls. Mechanical painful pressure stimuli were applied to the knee in both groups and ratings of evoked @entity158 and related brain activity examined. We observe that psychophysical properties and brain activation patterns of evoked @entity158 are essentially the same between @entity571 @entity1 and healthy subjects, and between worse and better @entity571 knees. In @entity571 @entity1 , stimulus-related brain activity could be distinguished from brain activity associated with spontaneous @entity158 . The former activated brain regions commonly observed for acute painful stimuli in healthy subjects, while the spontaneous @entity158 of @entity571 engaged prefrontal-limbic regions closely corresponding to areas observed for spontaneous @entity158 in other @entity1118 conditions, such as @entity615 and @entity9 . @entity625 -related clinical characteristics of knee @entity571 also mapped to prefrontal-limbic regions. In a subgroup of @entity1 (n=6) we examined brain activity changes for a 2-week, repeat measure, @entity3840 inhibitor ( @entity17852 ) therapy. Treatment decreased spontaneous @entity158 for the worse knee and clinical characteristics of @entity571 , and increased blood and csf levels of the drug which correlated positively with prefrontal-limbic brain activity. These findings indicate dissociation between mechanically induced and spontaneous @entity158 , the latter engaging brain regions involved in emotional assessment of the self, and challenge the standard clinical view regarding the nature of @entity158 .

title: Brain activity for chronic knee osteoarthritis: dissociating evoked XXXX from spontaneous @entity158 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['Arthritis']

entities_list: @entity17852 :: ('MESH:C406224', 'Chemical') :: ['valdecoxib']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['chronic back pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'OA knee pain', 'OA pain']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['Chronic pain', 'chronic pain']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['post-herpetic neuralgia']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: @entity1118 is a hallmark of @entity571 ( @entity571 ), yet little is known about its properties and representation in the brain. Here we use fMRI combined with psychophysics to study knee @entity158 in fourteen @entity571 @entity1 and nine healthy controls. Mechanical painful pressure stimuli were applied to the knee in both groups and ratings of evoked @entity158 and related brain activity examined. We observe that psychophysical properties and brain activation patterns of evoked @entity158 are essentially the same between @entity571 @entity1 and healthy subjects, and between worse and better @entity571 knees. In @entity571 @entity1 , stimulus-related brain activity could be distinguished from brain activity associated with spontaneous @entity158 . The former activated brain regions commonly observed for acute painful stimuli in healthy subjects, while the spontaneous @entity158 of @entity571 engaged prefrontal-limbic regions closely corresponding to areas observed for spontaneous @entity158 in other @entity1118 conditions, such as @entity615 and @entity9 . @entity625 -related clinical characteristics of knee @entity571 also mapped to prefrontal-limbic regions. In a subgroup of @entity1 (n=6) we examined brain activity changes for a 2-week, repeat measure, @entity3840 inhibitor ( @entity17852 ) therapy. Treatment decreased spontaneous @entity158 for the worse knee and clinical characteristics of @entity571 , and increased blood and csf levels of the drug which correlated positively with prefrontal-limbic brain activity. These findings indicate dissociation between mechanically induced and spontaneous @entity158 , the latter engaging brain regions involved in emotional assessment of the self, and challenge the standard clinical view regarding the nature of @entity158 .

title: Brain activity for chronic knee osteoarthritis: dissociating evoked @entity158 from spontaneous XXXX .

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: BACKGROUND: Few reports exist regarding the long-term clinical course of idiopathic @entity5970 . PURPOSE AND METHODS: We retrospectively studied the clinical courses of 8 @entity1 . The @entity1 were 4 @entity1 and 4 @entity1 aged 48.4 +/- 14.0 years (mean +/- SD) with idiopathic @entity5970 followed up for a minimum of more than 4 years. Mean follow-up was 13 years and 6 months (4-22 years and 9 months). RESULTS: There were 15 instances of whole-lung lavage and/or bronchoalveolar lavage in 7 @entity1 , and lavage was effective 40% of cases. Spontaneous improvement occurred 16 times and exacerbation occurred 7 times in 8 @entity1 . On chest X-ray films, the shadows disappeared in 5 of 8 (62.5%) @entity1 , and in 4 of 5 @entity1 , shadows disappeared 5 or more years after diagnosis of @entity5970 . Pulmonary shadows have not disappeared in the remaining 3 @entity1 at the time of writing but have shown improvement compared with first presentation. There were no deaths. CONCLUSION: As indicated in previous reports, the long-term outcome of idiopathic @entity5970 appears to be good.

title: [Eight cases of idiopathic XXXX followed up for more than 4 years].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women', 'men']

entities_list: @entity5970 :: ('MESH:D011649', 'Disease') :: ['pulmonary alveolar proteinosis']

answer: @entity5970 :: (MESH:D011649,Disease) :: ['pulmonary alveolar proteinosis']


abstract: Background. Globally, in ch @entity1 he prevalence of overweight and ob @entity28 s increasing, and this is associated with an increased risk of non-communicable diseases in adulthood. There is a need to examine the growing trends of overweight and ob @entity28 n ch @entity1 nd their consequences in low- and middle-income countries. OBJECTIVES: To describe the prevalence of, and determine the relationship between, stunting and overweight among ch @entity1 n two provinces of South Africa. METHODS: Secondary data analysis was conducted on anthropometric measurements of 36 - 119-month-old ch @entity1 rom Gauteng and Mpumalanga provinces (N=519) participating in the South African National Food Consumption Survey - Fortification Baseline I (2005). The International Obesity Task Force (IOTF) body mass index (BMI) reference percentiles were used to determine overweight and ob @entity28 The World Health Organization standards were used to derive z-scores. RESULTS: The prevalence of overweight was 12.0% (IOTF BMI >= 25 kg/m2), including 3.7% ob @entity28 IOTF BMI >= 30 kg/m2). The predominantly urban Gauteng Province had a significantly higher prevalence of overweight ch @entity1 14.1%) compared with Mpumalanga (6.3%) (p=0.0277). The prevalence of stunting was 17.0% (16.5% Gauteng, 18.2% Mpumalanga; p>0.05). There was a significant correlation (r=-0.32) between BMI and height-for-age z-scores (p<0.0001). In the ob @entity28 roup, 68.4% were stunted, while in the normal and underweight group only 13.6% were stunted. CONCLUSIONS: Stunted ch @entity1 ere more likely to be ob @entity28 Further research is necessary for clarity on the physiological mechanisms of this relationship. In the interim, prevention of stunting requires priority.

title: The relationship between stunting and overweight among XXXX from South Africa: Secondary analysis of the National Food Consumption Survey - Fortification Baseline I.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: OBJECTIVE: To observe the effect of childhood excessive @entity1386 on long-term risk of adult @entity2998 and arterial stiffness. METHODS: At baseline, in 1987, by using stratified cluster sampling design, 3 198 healthy @entity1 aged 6-18 were recruited from six primary schools and six middle schools from three districts (Chaoyang, Xicheng, and Haidian) in Beijing, with blood pressure, weight, height and left scapular skinfold thickness (LSSF) measured. From April 2010 to July 2012, 1 225 subjects were followed from childhood to adulthood. Questionnaire, biochemistry parameters, carotid-femoral pulse wave velocity (cfPWV), and carotid intima media thickness (cIMT) were measured at follow-up. Based on weight statuses in childhood and adulthood, subjects were classified into four groups (persistent non-overweight from childhood to adulthood, overweight in childhood but non-overweight in adulthood, non-overweight in childhood but overweight in adulthood, persistent overweight from childhood to adulthood). Multiple logistic regression model was used to analyze the association between weight statuses changing from childhood to adulthood and adult high cfPWV and high cIMT. RESULTS: The prevalence of overweight (including @entity28 ) at adulthood was 52.2% (639). Males had higher prevalence of smoking (62.5%(422/675) vs 29.4%(160/550),   (2)=133.21, P<0.001), drinking (52.1%(353/675) vs 26.1%(140/550),   (2)=87.13, P<0.001), overweight (including @entity28 ) (69.3% (468/675) vs 31.1% (171/550),   (2)=182.18, P< 0.001) than females. With adjusting for gender, age, and length of follow-up, the risk of high cfPWV and high cIMT increased by 26% and 58% for 1 units increase in BMI, and by 30% and 36% for 1 units increase in LSSF. Compared to subjects with persistent non-overweight from childhood to adulthood, subjects with overweight in childhood but non-overweight in adulthood had similar risks of high cfPWV (OR=1.59, 95%CI: 0.77-3.30)and high cIMT (OR=1.47, 95%CI:0.65-3.31). The risks of high cfPWV and high cIMT increased among subjects with non-overweight in childhood but overweight in adulthood (OR=1.92, 95%CI:1.37-2.68; OR=3.69, 95% CI:2.61- 5.23) and among subjects with persistent overweight from childhood to adulthood (OR=2.53, 95%CI:1.70-3.76; OR=5.37, 95%CI:3.62-7.97). CONCLUSIONS: We concluded that a overweight @entity1 changed to a healthy weight adult, the risks of adult subclinical @entity731 and arterial stiffness would not be increased.

title: [Effect of childhood XXXX on long-term risks of @entity2998 and arterial stiffness in adulthood].

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['adiposity']

answer: @entity1386 :: (MESH:D018205,Disease) :: ['adiposity']


abstract: OBJECTIVE: To observe the effect of childhood excessive @entity1386 on long-term risk of adult @entity2998 and arterial stiffness. METHODS: At baseline, in 1987, by using stratified cluster sampling design, 3 198 healthy @entity1 aged 6-18 were recruited from six primary schools and six middle schools from three districts (Chaoyang, Xicheng, and Haidian) in Beijing, with blood pressure, weight, height and left scapular skinfold thickness (LSSF) measured. From April 2010 to July 2012, 1 225 subjects were followed from childhood to adulthood. Questionnaire, biochemistry parameters, carotid-femoral pulse wave velocity (cfPWV), and carotid intima media thickness (cIMT) were measured at follow-up. Based on weight statuses in childhood and adulthood, subjects were classified into four groups (persistent non-overweight from childhood to adulthood, overweight in childhood but non-overweight in adulthood, non-overweight in childhood but overweight in adulthood, persistent overweight from childhood to adulthood). Multiple logistic regression model was used to analyze the association between weight statuses changing from childhood to adulthood and adult high cfPWV and high cIMT. RESULTS: The prevalence of overweight (including @entity28 ) at adulthood was 52.2% (639). Males had higher prevalence of smoking (62.5%(422/675) vs 29.4%(160/550),   (2)=133.21, P<0.001), drinking (52.1%(353/675) vs 26.1%(140/550),   (2)=87.13, P<0.001), overweight (including @entity28 ) (69.3% (468/675) vs 31.1% (171/550),   (2)=182.18, P< 0.001) than females. With adjusting for gender, age, and length of follow-up, the risk of high cfPWV and high cIMT increased by 26% and 58% for 1 units increase in BMI, and by 30% and 36% for 1 units increase in LSSF. Compared to subjects with persistent non-overweight from childhood to adulthood, subjects with overweight in childhood but non-overweight in adulthood had similar risks of high cfPWV (OR=1.59, 95%CI: 0.77-3.30)and high cIMT (OR=1.47, 95%CI:0.65-3.31). The risks of high cfPWV and high cIMT increased among subjects with non-overweight in childhood but overweight in adulthood (OR=1.92, 95%CI:1.37-2.68; OR=3.69, 95% CI:2.61- 5.23) and among subjects with persistent overweight from childhood to adulthood (OR=2.53, 95%CI:1.70-3.76; OR=5.37, 95%CI:3.62-7.97). CONCLUSIONS: We concluded that a overweight @entity1 changed to a healthy weight adult, the risks of adult subclinical @entity731 and arterial stiffness would not be increased.

title: [Effect of childhood @entity1386 on long-term risks of XXXX and arterial stiffness in adulthood].

answer: @entity2998 :: (MESH:D002340,Disease) :: ['carotid atherosclerosis']


abstract: A 43-year-old female with @entity454 secondary to focal segmental @entity631 was admitted to the hospital for @entity1353 after missing hemodialysis. On admission, the @entity1 was noted to have painful @entity272 consistent with @entity13375 on biopsy. While undergoing aggressive wound care, she developed @entity1032 and was found to be septic and started empirically on broad-spectrum antibiotics. The @entity1 was intubated on day 4 of admission owing to worsening mental status and @entity2185 . She had persistent positive blood cultures throughout her hospitalization despite appropriate antibiotic therapy. On day 25 of admission, the @entity1 was found to have @entity1661 . A radiograph revealed intra-abdominal free air, and the @entity1 was taken to the operating room where she was found to have perforated @entity39 bowel. The @entity1 expired on day 26 of admission. An autopsy revealed @entity13375 within the gut wall and within the dura of the central nervous system. While typically a disorder of subcutaneous tissue, @entity13375 can affect internal organs, which in this case resulted in a catastrophic outcome.

title: Abdominal catastrophe in a 43-year-old female with XXXX .

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['altered mental status']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrotic']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal distension']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions']

entities_list: @entity13375 :: ('MESH:D002115', 'Disease') :: ['calciphylaxis']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulosclerosis']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']

answer: @entity454 :: (MESH:D007676,Disease) :: ['end stage renal disease']


abstract: BACKGROUND: Laparoendoscopic single-site (LESS) surgery is beginning to include advanced laparoscopic operations such as Heller myotomy with anterior fundoplication. However, the efficacy of LESS Heller myotomy has not been established. This study aimed to evaluate the authors' initial experience with LESS Heller myotomy for @entity1318 . METHODS: Transumbilical LESS Heller myotomy with concomitant anterior fundoplication for @entity1318 was undertaken for 66 @entity1 after October 2007. Outcomes including operative time, complications, and length of hospital stay were recorded and compared with those for an earlier contiguous group of 66 consecutive @entity1 undergoing conventional multi-incision laparoscopic Heller myotomy with anterior fundoplication. Symptoms before and after myotomy were scored by the @entity1 using a Likert scale ranging from 0 (never/not severe) to 10 (always/very severe). Data were analyzed using the Mann-Whitney U test, the Wilcoxon matched-pairs test, and Fisher's exact test where appropriate. RESULTS: @entity1 undergoing LESS Heller myotomy were similar to those undergoing conventional laparoscopic Heller myotomy in gender, age, body mass index (BMI), @entity190 , and length of hospital stay. However, the @entity1 undergoing LESS Heller myotomies had operations of significantly longer duration (median, 117 vs. 93 min with the conventional laparoscopic approach) (p<0.003). For 11 @entity1 (16%) undergoing LESS Heller myotomy, additional ports/incisions were required. No @entity1 were converted to "open" operations, and no @entity1 had procedure-specific complications. Symptom reduction was dramatic and satisfying after both LESS and conventional laparoscopic myotomy with fundoplication. The symptom reduction was similar with the two procedures. The LESS approach left no apparent umbilical scar. CONCLUSION: Heller myotomy with anterior fundoplication effectively treats @entity1318 . The findings showed LESS Heller myotomy with anterior fundoplication to be feasible, safe, and efficacious. Although the LESS approach increases operative time, it does not increase procedure-related morbidity or hospital length of stay and avoids apparent umbilical scarring. Laparoendoscopic single-site surgery represents a paradigm shift to more minimally invasive surgery and is applicable to advanced laparoscopic operations such as Heller myotomy and anterior fundoplication.

title: Laparoendoscopic single-site Heller myotomy with anterior fundoplication for XXXX .

entities_list: @entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

answer: @entity1318 :: (MESH:D004931,Disease) :: ['achalasia']


abstract: @entity11769 Dpr belongs to the Dps family of bacterial and archaeal proteins that oxidize @entity8798 to @entity596 to protect microorganisms from oxidative damage. The oxidized @entity68 is subsequently deposited as @entity61248 inside a protein cavity, resulting in the formation of an @entity68 core. The size and the magnetic properties of the @entity68 core have attracted considerable attention for nanotechnological applications in recent years. Here, the magnetic and structural properties of the @entity68 core in wild-type Dpr and four cavity mutants were studied. All samples clearly demonstrated a superparamagnetic behavior in superconducting quantum interference device magnetometry and M  ssbauer spectroscopy compatible with that of superparamagnetic @entity61248 nanoparticles. However, all the mutants exhibited higher magnetic moments than the wild-type protein. Furthermore, measurement of the @entity68 content with inductively coupled plasma mass spectrometry revealed a smaller amount of @entity68 in the @entity68 cores of the mutants, suggesting that the mutations affect nucleation and @entity68 deposition inside the cavity. The X-ray crystal structures of the mutants revealed no changes compared with the wild-type crystal structure; thus, the differences in the magnetic moments could not be attributed to structural changes in the protein. Extended X-ray absorption fine structure measurements showed that the coordination geometry of the @entity68 cores of the mutants was similar to that of the wild-type protein. Taken together, these results suggest that mutation of the residues that surround the @entity68 storage cavity could be exploited to selectively modify the magnetic properties of the @entity68 core without affecting the structure of the protein and the geometry of the @entity68 core.

title: Magnetic properties and structural characterization of iron oxide nanoparticles formed by XXXX Dpr and four mutants.

entities_list: @entity11769 :: ('1307', 'Species') :: ['Streptococcus suis']

entities_list: @entity61248 :: ('MESH:C092844', 'Chemical') :: ['ferrihydrite']

answer: @entity11769 :: (1307,Species) :: ['Streptococcus suis']


abstract: BACKGROUND: Distinguishing between actions that are more likely or less likely to be rewarded is a critical aspect of goal-directed decision making. However, neuroanatomic and molecular mechanisms are not fully understood. METHODS: We used anterograde tracing, viral-mediated gene silencing, functional disconnection strategies, pharmacologic rescue, and designer receptors exclusively activated by designer drugs (DREADDs) to determine the anatomic and functional connectivity between the @entity550 ( @entity550 ) and the amygdala in @entity19 . In particular, we knocked down @entity9140 ( @entity9140 ) bilaterally in the @entity550 or generated an @entity550 "disconnection" by pairing unilateral @entity550 @entity9140 knockdown with lesions of the contralateral amygdala. We characterized decision-making strategies using a task in which @entity19 selected actions based on the likelihood that they would be reinforced. Additionally, we assessed the effects of DREADD-mediated @entity550 inhibition on the consolidation of action-outcome conditioning. RESULTS: As in other species, the @entity550 projects to the basolateral amygdala and dorsal striatum in @entity19 . Bilateral @entity9140 knockdown within the ventrolateral @entity550 and unilateral @entity9140 knockdown accompanied by lesions of the contralateral amygdala impede goal-directed response selection, implicating @entity9140 -expressing @entity550 projection neurons in selecting actions based on their consequences. The @entity4149 receptor kinase B agonist @entity21537 rescues action selection and increases dendritic spine density on excitatory neurons in the @entity550 . @entity22636 inhibition also rescues goal-directed response strategies, linking neural remodeling with outcome-based decision making. Finally, DREADD-mediated @entity550 inhibition weakens new action-outcome memory. CONCLUSIONS: Activity-dependent and @entity9140 -dependent neuroplasticity within the @entity550 coordinate outcome-based decision making through interactions with the amygdala. These interactions brake reward-seeking habits, a putative factor in multiple psychopathologies.

title: Connections of the @entity19 Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by XXXX .

entities_list: @entity9140 :: ('12064(Tax:10090)', 'Gene') :: ['Bdnf', 'brain-derived neurotrophic factor', 'BDNF']

entities_list: @entity550 :: ('MESH:D000303', 'Disease') :: ['OFC', 'orbitofrontal cortex', 'OFC-amygdala']

entities_list: @entity21537 :: ('MESH:C485383', 'Chemical') :: ['7,8-dihydroxyflavone']

answer: @entity9140 :: (12064(Tax:10090),Gene) :: ['Brain-Derived Neurotrophic Factor']


abstract: BACKGROUND: Distinguishing between actions that are more likely or less likely to be rewarded is a critical aspect of goal-directed decision making. However, neuroanatomic and molecular mechanisms are not fully understood. METHODS: We used anterograde tracing, viral-mediated gene silencing, functional disconnection strategies, pharmacologic rescue, and designer receptors exclusively activated by designer drugs (DREADDs) to determine the anatomic and functional connectivity between the @entity550 ( @entity550 ) and the amygdala in @entity19 . In particular, we knocked down @entity9140 ( @entity9140 ) bilaterally in the @entity550 or generated an @entity550 "disconnection" by pairing unilateral @entity550 @entity9140 knockdown with lesions of the contralateral amygdala. We characterized decision-making strategies using a task in which @entity19 selected actions based on the likelihood that they would be reinforced. Additionally, we assessed the effects of DREADD-mediated @entity550 inhibition on the consolidation of action-outcome conditioning. RESULTS: As in other species, the @entity550 projects to the basolateral amygdala and dorsal striatum in @entity19 . Bilateral @entity9140 knockdown within the ventrolateral @entity550 and unilateral @entity9140 knockdown accompanied by lesions of the contralateral amygdala impede goal-directed response selection, implicating @entity9140 -expressing @entity550 projection neurons in selecting actions based on their consequences. The @entity4149 receptor kinase B agonist @entity21537 rescues action selection and increases dendritic spine density on excitatory neurons in the @entity550 . @entity22636 inhibition also rescues goal-directed response strategies, linking neural remodeling with outcome-based decision making. Finally, DREADD-mediated @entity550 inhibition weakens new action-outcome memory. CONCLUSIONS: Activity-dependent and @entity9140 -dependent neuroplasticity within the @entity550 coordinate outcome-based decision making through interactions with the amygdala. These interactions brake reward-seeking habits, a putative factor in multiple psychopathologies.

title: Connections of the XXXX Orbitofrontal Cortex and Regulation of Goal-Directed Action Selection by @entity9140 .

answer: @entity19 :: (10090,Species) :: ['Mouse']


abstract: The @entity3686 ( @entity3686 ) is caused by mutations in @entity3687 and exhibits a widely variable expression. Usually @entity3686 is heralded with continuous microhematuria which rapidly progresses to @entity644 , @entity101 and @entity454 ( @entity454 ) by adolescence, frequently accompanied by @entity1274 and @entity2194 . Milder forms of @entity3686 also exist. We studied 42 @entity1 (19M, 23F) of nine Hellenic families suspected clinically of X-linked @entity3686 who presented with marked phenotypic heterogeneity. We identified mutations in @entity3687 in six families. Two males with nonsense mutation @entity72808 reached @entity454 by ages 14 and 18. Frameshift mutation @entity72809 followed the same course with early onset @entity8 and @entity2319 . However, two males with the milder missense mutation @entity72810 , reached @entity454 after 39 years and one @entity1 showed @entity8 ( @entity8 ). Another 5/8 affected males with missense mutation @entity72811 also developed @entity454 between 30 and 57 years, while three exhibit only mild @entity177 ( @entity177 ). The data support previous findings that certain mutations are associated with milder phenotypes and confirm that mutation @entity72810 may be expressed as @entity8 with @entity13634 . Similar conclusions apply for missense mutation @entity72811 . Interestingly, mutations @entity72810 and @entity72811 are near the 12th natural interruption of @entity3687 triple helical domain, which may explain the milder phenotype.

title: @entity3686 in Hellenic families: phenotypic heterogeneity and mutations near interruptions of the collagen domain in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular complications']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['thin basement membrane nephropathy', 'renal involvement', 'TBMN']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity3686 :: ('MESH:D009394', 'Disease') :: ['X-linked Alport syndrome', 'ATS']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure', 'CRF']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural deafness']

entities_list: @entity13634 :: ('MESH:C562476', 'Disease') :: ['familial hematuria']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['chronic or end-stage renal disease', 'ESRD']

answer: @entity3687 :: (1287,Gene) :: ['COL4A5']