abstract: BACKGROUND: Previous radiation for @entity263 ( @entity263 ) contra-indicates neoadjuvant chemoradiotherapy for @entity5 ( @entity5 ) because of risk of cumulative radiation dose @entity137 . Postoperative outcomes after proctectomy have not been well studied in these @entity1 who did not receive optimal treatment. METHODS: Eighty-four consecutive male @entity1 underwent surgery for stage II-III mid or low @entity5 between 2002 and 2011. @entity1 who previously received radiation for @entity263 (n   =   8) and @entity1 who had not previously undergone radiation for @entity263 but who received neoadjuvant chemoradiotherapy for @entity5 (n   =   64) were retrospectively compared. RESULTS: Previous radiation for @entity263 was an independent factor that significantly increased intraoperative (25% vs. 1.6%, P   =   0.002) and postoperative morbidities (62.5% vs. 28.1%, P   =   0.028), @entity834 (62.5% vs. 12.5%, P   <   0.001) and definitive stoma rates (25% vs. 17.4%, P   =   0.022). It significantly altered median overall survival (32.0 vs. 130.6 months, P   =   0.05) and local recurrence-free survival rates (14.0 months vs. "median not reached," P   =   0.016). CONCLUSIONS: This is the first report of altered survival rates after proctectomy in @entity1 who had previously received radiation for @entity263 . Postoperative morbidity and definitive defunctioning stoma rates were significantly increased in these @entity1 with poor prognoses. Therapeutic strategies should thus be individualized. Large, multicenter cohort studies are needed. J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Previous radiation for prostate @entity5 alters surgical and oncologic outcomes after XXXX surgery.

answer: @entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']


abstract: OBJECTIVE: To demonstrate the benefit of complexity metrics such as the @entity7319 ( @entity7319 ) and monitor units (MUs) in multi-institutional audits of @entity34 ( @entity34 ) delivery. METHODS: 39 @entity34 treatment plans were analysed using @entity7319 and MU. A virtual phantom planning exercise was planned and independently measured using the PTW Octavius(  ) phantom and seven29(  ) 2D array (PTW-Freiburg GmbH, Freiburg, Germany). @entity7319 and MU were compared with the median gamma index pass rates (2%/2 and 3%/3   mm) and plan quality. The treatment planning systems (TPS) were grouped by @entity34 modelling being specifically designed for the linear accelerator manufacturer's own treatment delivery system (Type 1) or independent of vendor for @entity34 delivery (Type 2). Differences in plan complexity ( @entity7319 and MU) between TPS types were compared. RESULTS: For Varian(  ) linear accelerators (Varian(  ) Medical Systems, Inc., Palo Alto, CA), @entity7319 and MU were significantly correlated with gamma pass rates. Type 2 TPS created poorer quality, more complex plans with significantly higher MUs and @entity7319 than Type 1 TPS. Plan quality was significantly correlated with MU for Type 2 plans. A statistically significant correlation was observed between MU and @entity7319 for all plans (R   =   -0.84, p   <   0.01). CONCLUSION: MU and @entity7319 have a role in assessing plan complexity in audits along with plan quality metrics. Plan complexity metrics give some indication of plan deliverability but should be analysed with plan quality. Advances in knowledge: Complexity metrics were investigated for a national rotational audit involving 34 institutions and they showed value. The metrics found that more complex plans were created for planning systems which were independent of vendor for @entity34 delivery.

title: The role of complexity metrics in a multi-institutional dosimetry audit of XXXX .

entities_list: @entity7319 :: ('MESH:D030401', 'Disease') :: ['modulation complexity score', 'MCS']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['VMAT', 'volumetric-modulated arc therapy']

answer: @entity34 :: (MESH:D016609,Disease) :: ['VMAT']


abstract: BACKGROUND: Recently, two simple clinical scores were published to predict survival in @entity130 @entity1 . Both scores may successfully guide major @entity130 triage, but neither has been independently validated in a hospital setting. METHODS: This is a cohort study with 30-day mortality as the primary outcome to validate two new @entity130 scores-Mechanism, Glasgow @entity772 Scale (GCS), Age, and Pressure (MGAP) score and GCS, Age and Pressure (GAP) score-using data from the UK @entity130 Audit and Research Network. First, an assessment of discrimination, using the area under the receiver operating characteristic (ROC) curve, and calibration, comparing mortality rates with those originally published, were performed. Second, we calculated sensitivity, specificity, predictive values, and likelihood ratios for prognostic score performance. Third, we propose new cutoffs for the risk categories. RESULTS: A total of 79,807 adult (>= 16 years) major @entity130 @entity1 (2000-2010) were included; 5,474 (6.9%) died. Mean (SD) age was 51.5 (22.4) years, median GCS score was 15 (interquartile range, 15-15), and median Injury Severity Score (ISS) was 9 (interquartile range, 9-16). More than 50% of the @entity1 had a low-risk GAP or MGAP score (1% mortality). With regard to discrimination, areas under the ROC curve were 87.2% for GAP score (95% confidence interval, 86.7-87.7) and 86.8% for MGAP score (95% confidence interval, 86.2-87.3). With regard to calibration, 2,390 (3.3%), 1,900 (28.5%), and 1,184 (72.2%) @entity1 died in the low, medium, and high GAP risk categories, respectively. In the low- and medium-risk groups, these were almost double the previously published rates. For MGAP, 1,861 (2.8%), 1,455 (15.2%), and 2,158 (58.6%) @entity1 died in the low-, medium-, and high-risk categories, consonant with results originally published. Reclassifying score point cutoffs improved likelihood ratios, sensitivity and specificity, as well as areas under the ROC curve. CONCLUSION: We found both scores to be valid triage tools to stratify emergency department @entity1 , according to their risk of @entity204 . MGAP calibrated better, but GAP slightly improved discrimination. The newly proposed cutoffs better differentiate risk classification and may therefore facilitate hospital resource allocation. LEVEL OF EVIDENCE: Prognostic study, level II.

title: Validation and reclassification of MGAP and GAP in hospital settings using data from the XXXX Audit and Research Network.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['Trauma']


abstract: BACKGROUND: As emergency care becomes increasingly regionalized, systems planners must determine how system expansion impacts existing system assets. We hypothesized that accrediting new Level II and III @entity130 centers impacted the @entity130 @entity1 census and severity at a nearby Level I @entity130 center and estimated the magnitude of the impact. METHODS: We conducted an interrupted time series analysis using monthly @entity1 counts during the past 10 years for five @entity130 centers located near one another in Pennsylvania. The Level I center (TC-A) operated for the entire period. A Level II center 39 miles away was accredited after 70 months ( @entity17341 ), one Level III center 46 miles away was accredited after 95 months but lost accreditation after 11 months ( @entity35805 ), and two other Level III centers 40 miles and 45 miles away were accredited after 107 months ( @entity69223 and TC-E). RESULTS: Monthly @entity1 volume at the Level I center, which increased gradually over the study and summed to 25,120 @entity1 , decreased by 10.8% (p < 0.05) when @entity17341 was accredited and decreased by an additional 12.9% (p < 0.05) when @entity69223 and @entity4966 were accredited simultaneously. No change stemmed from temporarily accrediting @entity35805 . Ultimately, the Level I center treated 1,903 fewer @entity1 than expected over 51 months, an 11.9% volume reduction, and @entity1 severity remained consistent but mortality decreased. CONCLUSION: Accrediting Level II and Level III @entity130 centers reduced @entity1 volume and reduced overall mortality at a nearby Level I center. Strategic planning of statewide @entity130 systems can help balance rapid access to care with maintenance of adequate annual @entity1 volumes of critically injured @entity1 . LEVEL OF EVIDENCE: Epidemiologic study, Level IV.

title: Impact of adding Level II and III @entity130 centers on volume and disease severity at a nearby Level I XXXX center.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: BACKGROUND: As emergency care becomes increasingly regionalized, systems planners must determine how system expansion impacts existing system assets. We hypothesized that accrediting new Level II and III @entity130 centers impacted the @entity130 @entity1 census and severity at a nearby Level I @entity130 center and estimated the magnitude of the impact. METHODS: We conducted an interrupted time series analysis using monthly @entity1 counts during the past 10 years for five @entity130 centers located near one another in Pennsylvania. The Level I center (TC-A) operated for the entire period. A Level II center 39 miles away was accredited after 70 months ( @entity17341 ), one Level III center 46 miles away was accredited after 95 months but lost accreditation after 11 months ( @entity35805 ), and two other Level III centers 40 miles and 45 miles away were accredited after 107 months ( @entity69223 and TC-E). RESULTS: Monthly @entity1 volume at the Level I center, which increased gradually over the study and summed to 25,120 @entity1 , decreased by 10.8% (p < 0.05) when @entity17341 was accredited and decreased by an additional 12.9% (p < 0.05) when @entity69223 and @entity4966 were accredited simultaneously. No change stemmed from temporarily accrediting @entity35805 . Ultimately, the Level I center treated 1,903 fewer @entity1 than expected over 51 months, an 11.9% volume reduction, and @entity1 severity remained consistent but mortality decreased. CONCLUSION: Accrediting Level II and Level III @entity130 centers reduced @entity1 volume and reduced overall mortality at a nearby Level I center. Strategic planning of statewide @entity130 systems can help balance rapid access to care with maintenance of adequate annual @entity1 volumes of critically injured @entity1 . LEVEL OF EVIDENCE: Epidemiologic study, Level IV.

title: Impact of adding Level II and III XXXX centers on volume and disease severity at a nearby Level I @entity130 center.

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: @entity2176 resistant @entity6375 (VREF) ia an emerging and challenging nosocomial pathogen. This study aimed to determine the prevalence, risk factors and clonal relationships between different VREF isolates in the intensive care units (ICUs) of the university hospitals in our geographic location. This prospective study was conducted from July, 2012 until September, 2013 on 781 @entity1 who were admitted to the ICUs of the Mansoura University Hospitals (MUHs), and fulfilled the healthcare-associated @entity281 (HAI) criteria. Susceptibility testing was determined using the disk diffusion method. The clonal relationships were evaluated with pulsed field gel electrophoresis (PFGE). Out of 52 @entity6375 isolates, 12 (23.1%) were @entity2176 resistant. The significant risk factors for the @entity281 were: transfer to the ICU from a ward, @entity177 , an extended ICU stay and use of third-generation @entity2886 , @entity801 , or @entity2177 . PFGE with the 12 isolates showed 9 different patterns; 3 belonged to the same pulsotype and another 2 carried a second pulsotypes. The similar pulsotypes isolates were isolated from ICUs of one hospital (EICUs); however, all of the isolates from the other ICUs had different patterns. Infection control policy, in conjunction with antibiotic stewardship, is important to combat VREF transmission in these high-risk @entity1 .

title: Healthcare-associated XXXX resistant @entity6375 infections in the Mansoura University Hospitals intensive care units, Egypt.

entities_list: @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin']

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin', 'Vancomycin']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity2886 :: ('MESH:D002511', 'Chemical') :: ['cephalosporins']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'VREF infections']

entities_list: @entity6375 :: ('1352', 'Species') :: ['E. faecium', 'Enterococcus faecium']

answer: @entity2176 :: (MESH:D014640,Chemical) :: ['vancomycin']


abstract: @entity2176 resistant @entity6375 (VREF) ia an emerging and challenging nosocomial pathogen. This study aimed to determine the prevalence, risk factors and clonal relationships between different VREF isolates in the intensive care units (ICUs) of the university hospitals in our geographic location. This prospective study was conducted from July, 2012 until September, 2013 on 781 @entity1 who were admitted to the ICUs of the Mansoura University Hospitals (MUHs), and fulfilled the healthcare-associated @entity281 (HAI) criteria. Susceptibility testing was determined using the disk diffusion method. The clonal relationships were evaluated with pulsed field gel electrophoresis (PFGE). Out of 52 @entity6375 isolates, 12 (23.1%) were @entity2176 resistant. The significant risk factors for the @entity281 were: transfer to the ICU from a ward, @entity177 , an extended ICU stay and use of third-generation @entity2886 , @entity801 , or @entity2177 . PFGE with the 12 isolates showed 9 different patterns; 3 belonged to the same pulsotype and another 2 carried a second pulsotypes. The similar pulsotypes isolates were isolated from ICUs of one hospital (EICUs); however, all of the isolates from the other ICUs had different patterns. Infection control policy, in conjunction with antibiotic stewardship, is important to combat VREF transmission in these high-risk @entity1 .

title: Healthcare-associated @entity2176 resistant XXXX infections in the Mansoura University Hospitals intensive care units, Egypt.

answer: @entity6375 :: (1352,Species) :: ['Enterococcus faecium']


abstract: BACKGROUND CONTEXT: Corrective surgery for @entity1615 ( @entity1615 ) leads to vertical growth arrest of the instrumented spine. This might be offset by the immediate gain in spinal height (SH) as a result of correction of the curvature. PURPOSE: This study aimed to identify predictors of gain in SH following corrective surgery for @entity1615 . We present a unique model to predict postoperative height prior to intervention, which could contribute to the preoperative counseling and consenting process. STUDY DESIGN: This was a retrospective case series. All surgeries were performed by one of four substantive pediatric spinal surgeons within a single regional center over a 3.5-year period. @entity1 SAMPLE: There were 104 @entity1 who had instrumented posterior spinal fusion for @entity1615 included. There were 93 females, and the age range was from 11 to 17 years. All @entity1 had posterior instrumented fusion using rods and anchors (pedicle screws  hooks). OUTCOME MEASURES: Postoperative SH was the primary outcome measure. The SH (C7-L5) and Cobb angles were measured from a pre- and postoperative standing X-ray of each @entity1 . METHODS: Variables associated with @entity1 (demographic and radiological) and the surgical constructs were analyzed for predictability of @entity1017 . A model was derived including only significant predictors of substantive importance using hierarchical regression methods. Cross-validation procedures verified the adequacy of the model fit. Analysis was performed using IBM SPSS Statistics for Windows version 20.0 (IBM Corp. Armonk, NY, USA). RESULTS: The major curve was thoracic in 90% of cases. The number of vertebrae fused ranged from 5 to 15. The average preoperative Cobb angle was 66  , with an average correction of 45  . The average change in SH was 4.66   cm (SD 2.13   cm). The model presented included preoperative height, preoperative Cobb angle, and number of vertebrae within the construct, with coefficients of 1.00 (95% CI: 0.90, 1.09), 0.067 (95% CI: 0.039, 0.095), and 0.26 (95% CI: 0.11, 0.41), respectively. This model had an adjusted-R(2) value of 0.83 and a R(2) for prediction of 0.79, and can be shown to have similar predictive capability as a model comprising a wider range of predictors. CONCLUSION: The greatest postoperative height values following posterior spinal fusion for @entity1615 could be expected from a @entity1 with greater preoperative height and Cobb angle, and whose construct spans a large number of vertebrae.

title: Change in spinal height following correction of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENT']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['height gain']

entities_list: @entity1615 :: ('OMIM:181800', 'Disease') :: ['AIS', 'adolescent idiopathic scoliosis']

answer: @entity1615 :: (OMIM:181800,Disease) :: ['adolescent idiopathic scoliosis']


abstract: OBJECTIVES: To investigate the optimal threshold of subtraction method for quantification of air trapping on co-registered CT in @entity1030 @entity1 in correlation with pulmonary function parameters. METHODS: From June 2005 to October 2010, 174 @entity1 were included in our study. Inspiration and expiration CT were performed followed by non-rigid registration using in-house software. The subtraction value per voxel between inspiration and registered expiration CT was obtained, and volume fraction of air trapping (air trapping index, ATI), using variable thresholds was calculated. ATI, expiration/inspiration ratio of mean lung density (E/I @entity8431 ) and the percentage of lung voxels below -856  HU on expiration CT (Exp-856) were correlated with FEF25-75% and RV/TLC. RESULTS: The highest correlation coefficient with FEF25-75% was -0.656, using the threshold of 80  HU. As for RV/TLC, the highest correlation coefficient was 0.664, using the threshold of 30  HU. When plotting the relationship between subtraction thresholds and FEF25-75% and RV/TLC, the threshold of 60  HU was most suitable (r   =   -0.649 and 0.651). Those correlation coefficients were comparable to the results with E/I @entity8431 (r   =   -0.670 and 0.657) and Exp-856 (r   =   -0.604 and 0.565). CONCLUSIONS: The optimal threshold for quantification of air trapping was 60  HU and showed comparable correlations with pulmonary function parameters. KEY POINTS:     The optimal CT threshold of subtraction method for air trapping was 60  HU.     ATI with 60  HU threshold was comparable to E/I @entity8431 and Exp -856 .     @entity2415 may substantially contribute to air trapping with statistical significance (P   <   0.001).

title: Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in XXXX @entity1 .

entities_list: @entity2415 :: ('MESH:D004646', 'Disease') :: ['Emphysema']

answer: @entity1030 :: (MESH:D029424,Disease) :: ['COPD']


abstract: OBJECTIVES: To investigate the optimal threshold of subtraction method for quantification of air trapping on co-registered CT in @entity1030 @entity1 in correlation with pulmonary function parameters. METHODS: From June 2005 to October 2010, 174 @entity1 were included in our study. Inspiration and expiration CT were performed followed by non-rigid registration using in-house software. The subtraction value per voxel between inspiration and registered expiration CT was obtained, and volume fraction of air trapping (air trapping index, ATI), using variable thresholds was calculated. ATI, expiration/inspiration ratio of mean lung density (E/I @entity8431 ) and the percentage of lung voxels below -856  HU on expiration CT (Exp-856) were correlated with FEF25-75% and RV/TLC. RESULTS: The highest correlation coefficient with FEF25-75% was -0.656, using the threshold of 80  HU. As for RV/TLC, the highest correlation coefficient was 0.664, using the threshold of 30  HU. When plotting the relationship between subtraction thresholds and FEF25-75% and RV/TLC, the threshold of 60  HU was most suitable (r   =   -0.649 and 0.651). Those correlation coefficients were comparable to the results with E/I @entity8431 (r   =   -0.670 and 0.657) and Exp-856 (r   =   -0.604 and 0.565). CONCLUSIONS: The optimal threshold for quantification of air trapping was 60  HU and showed comparable correlations with pulmonary function parameters. KEY POINTS:     The optimal CT threshold of subtraction method for air trapping was 60  HU.     ATI with 60  HU threshold was comparable to E/I @entity8431 and Exp -856 .     @entity2415 may substantially contribute to air trapping with statistical significance (P   <   0.001).

title: Optimal threshold of subtraction method for quantification of air-trapping on coregistered CT in @entity1030 XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: A method based on the combination of hollow fiber liquid-liquid-liquid microextraction and solid-phase microextraction (SPME) followed by gas chromatography-electron capture detection was developed for the determination of @entity16648 in water and wastewater samples. Silica microstructures fabricated on the surface of a stainless steel wire were coated by an organic solvent and used as a SPME fiber. The analytes were extracted through a hollow fiber membrane containing @entity37125 from sample solution to an alkaline aqueous acceptor phase. They were then extracted and in situ derivatized on the SPME fiber using @entity24011 . Experimental parameters such as the type of extraction solvent, acceptor phase @entity6674 concentration, donor phase @entity5828 concentration, the amount of derivatizing reagent, salt concentration, stirring rate and extraction time were investigated and optimized. The precision of the method for the analytes at 0.02-30 gL(-1) concentration level ranged from 7.1 to 10.2% (as intra-day relative standard deviation) and 6.4 to 9.8% (as inter-day relative standard deviation). The linear dynamic ranges were in the interval of 5-500 gL(-1), 0.05-5 gL(-1), 0.02-1 gL(-1) and 0.001-0.5 gL(-1) for @entity39512 , @entity29359 , @entity24502 and @entity211 , respectively. The enrichment factors were between 432 and 785. The limits of detection were in the range of 0.0004-1.2 gL(-1). Tap water, well water and wastewater samples were also analyzed to evaluate the method capability for real sample analysis.

title: Hollow fiber liquid-liquid-liquid microextraction followed by solid-phase microextraction and in situ derivatization for the determination of XXXX by gas chromatography-electron capture detection.

entities_list: @entity24502 :: ('MESH:C024564', 'Chemical') :: ['2,4,6-trichlorophenol']

entities_list: @entity211 :: ('MESH:D010416', 'Chemical') :: ['pentachlorophenol']

entities_list: @entity29359 :: ('MESH:C004762', 'Chemical') :: ['2,4-dichlorophenol']

entities_list: @entity16648 :: ('MESH:D002733', 'Chemical') :: ['chlorophenols']

entities_list: @entity24011 :: ('MESH:C031800', 'Chemical') :: ['acetic anhydride']

entities_list: @entity39512 :: ('MESH:C030683', 'Chemical') :: ['2-chlorophenol']

answer: @entity16648 :: (MESH:D002733,Chemical) :: ['chlorophenols']


abstract: BACKGROUND: Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used modalities in the treatment of @entity1569 . However, despite its high efficacy, conventional Goeckerman treatment has fallen out of favor in recent years and some institutions are now using NBUVB with coal tar as their regimen. OBJECTIVE: To evaluate the efficacy of NB-UVB, Goeckerman therapy and the effect of addition of @entity554 to the treatment regimen in the treatment of @entity1569 ,. @entity1 AND METHODS: A retrospective analysis of 65 @entity1 who underwent 81 courses of treatment in our department was undertaken. The efficacy of NB-UVB and Goeckerman therapy individually, and in combination with @entity14028 was assessed. Data were analysed to evaluate the contribution of @entity14028 to these modalities. RESULTS: PASI-75 responses in the NB-UVB, @entity554 + NB-UVB (re-NB), Goeckerman and @entity554 + Goeckerman (re-Goeckerman) groups were achieved for 12 of 31 @entity1 (39%), 13 of 21 @entity1 (62%), 15 of 17 @entity1 (88%) and 10 of 12 @entity1 , respectively. The addition of @entity14028 to both modalities reduced both the number of sessions and the cumulative ultraviolet-B dose delivered. LIMITATIONS: This is a retrospective study, the @entity1 were not randomized and the number of @entity1 in the treatment groups were dissimilar. CONCLUSION: Goeckerman therapy is more effective than NB-UVB phototherapy. Although the addition of @entity14028 to both NB-UVB and Goeckerman therapy did not contribute to treatment outcomes in terms of PASI-75 responses, it enabled a reduction in UV exposures and enhanced efficacy.

title: Narrow band ultraviolet-B versus Goeckerman therapy for @entity1569 with and without XXXX : A retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity14028 :: ('MESH:D017255', 'Chemical') :: ['acitretin']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity554 :: ('CHEBI:26537', 'Chemical') :: ['retinoid']

answer: @entity14028 :: (MESH:D017255,Chemical) :: ['acitretin']


abstract: BACKGROUND: Narrow band ultraviolet-B (NB-UVB) is now one of the most widely used modalities in the treatment of @entity1569 . However, despite its high efficacy, conventional Goeckerman treatment has fallen out of favor in recent years and some institutions are now using NBUVB with coal tar as their regimen. OBJECTIVE: To evaluate the efficacy of NB-UVB, Goeckerman therapy and the effect of addition of @entity554 to the treatment regimen in the treatment of @entity1569 ,. @entity1 AND METHODS: A retrospective analysis of 65 @entity1 who underwent 81 courses of treatment in our department was undertaken. The efficacy of NB-UVB and Goeckerman therapy individually, and in combination with @entity14028 was assessed. Data were analysed to evaluate the contribution of @entity14028 to these modalities. RESULTS: PASI-75 responses in the NB-UVB, @entity554 + NB-UVB (re-NB), Goeckerman and @entity554 + Goeckerman (re-Goeckerman) groups were achieved for 12 of 31 @entity1 (39%), 13 of 21 @entity1 (62%), 15 of 17 @entity1 (88%) and 10 of 12 @entity1 , respectively. The addition of @entity14028 to both modalities reduced both the number of sessions and the cumulative ultraviolet-B dose delivered. LIMITATIONS: This is a retrospective study, the @entity1 were not randomized and the number of @entity1 in the treatment groups were dissimilar. CONCLUSION: Goeckerman therapy is more effective than NB-UVB phototherapy. Although the addition of @entity14028 to both NB-UVB and Goeckerman therapy did not contribute to treatment outcomes in terms of PASI-75 responses, it enabled a reduction in UV exposures and enhanced efficacy.

title: Narrow band ultraviolet-B versus Goeckerman therapy for XXXX with and without @entity14028 : A retrospective study.

answer: @entity1569 :: (MESH:D011565,Disease) :: ['psoriasis']


abstract: BACKGROUND: Bronchial artery embolisation (BAE) becomes a mainstay in the treatment of @entity5492 . OBJECTIVE: To characterise @entity1 with @entity5492 undergoing bronchial artery angiography (BAA) for embolisation, evaluating outcomes. METHODS: We retrospectively evaluated @entity1 with acute severe or chronic recurrent @entity5492 admitted to the Pulmonology department and submitted to BAA for purpose of embolisation. RESULTS: A total of 88 @entity1 were submitted to BAA, 47 (53.4%) were male, with a mean age of 61.4  15.8 years. In 64 (72.7%) @entity1 , @entity5492 presented as chronic recurrent episodes. @entity5492 was considered severe in 40 (45.5%) @entity1 . @entity4595 (other than @entity1577 ) (n=35; 38.0%) and @entity378 sequelae (n=31; 35.2) were the major aetiology for @entity5492 . The main angiographic abnormality was @entity1184 and tortuosity (n=68; 77.3%). BAE was performed in 67 (76.1%) of the 88 @entity1 submitted to BAA. Immediate success was achieved in 66 (98.5%) @entity1 . Recurrence of @entity5492 occurred in 25 (37.3%) @entity1 , and was related to presence of shunting (p=0.049). The procedure-related complications were self-limited. CONCLUSION: Our results suggest that BAE is a safe and effective treatment for acute severe and chronic recurrent @entity5492 , supporting the current literature. Besides this, bleeding recurrence was relatively high, and correlated with presence of systemic pulmonary shunting.

title: Bronchial artery embolisation in management of XXXX - A retrospective analysis in a tertiary university hospital.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity4595 :: ('MESH:D001987', 'Disease') :: ['Bronchiectasis']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

entities_list: @entity5492 :: ('MESH:D006469', 'Disease') :: ['hemoptysis', 'Hemoptysis']

entities_list: @entity1577 :: ('MESH:D003550', 'Disease') :: ['cystic fibrosis']

answer: @entity5492 :: (MESH:D006469,Disease) :: ['hemoptysis']


abstract: BACKGROUND: The purpose of the present study was to investigate the existence of @entity854 in the white matter circuit in @entity64 @entity1 and its relationship to @entity308 episodes. To target the prevention of @entity308 , we also investigated the relationship between lymphocyte subsets and @entity75 in @entity1 . METHODS: @entity1 included 18 @entity1 with acute @entity385 and 22 healthy control subjects. Diffusion tensor imaging was performed. Whole-brain voxel-based analysis was used to compare fractional anisotropy (FA) between groups. Blood samples were obtained, and the lymphocyte subsets were evaluated using flow cytometry. Follow-up examinations were conducted on 12 @entity1 at 6 months. RESULTS: FA was decreased in the bilateral anterior limb of the internal capsule in @entity64 @entity1 . At the 6-month follow-up examination, there was a significant increase in FA, which was associated with a lower @entity308 scale score. @entity1 showed a decreased percentage of circulated regulatory T lymphocytes, and the degree of reduction was related to the decrease in the FA value in the internal capsule. CONCLUSIONS: FA reductions in the anterior limb of the internal capsule cause @entity2122 and confer a biological vulnerability, which in combination with environmental stressors results in the onset of @entity308 . Our findings also demonstrated the possibility of preventing @entity64 by targeting the role of regulatory T lymphocytes in brain tissue repair and regeneration after @entity64 .

title: XXXX in white matter, regulatory T lymphocytes, and @entity308 after @entity64 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Participants']

entities_list: @entity2122 :: ('MESH:D019465', 'Disease') :: ['abnormality in the frontal-subcortical circuits']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['post-stroke depression', 'stroke']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'depressive']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebral abnormalities']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['microstructure abnormalities']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity854 :: (MESH:D018376,Disease) :: ['Microstructural abnormality']


abstract: BACKGROUND: The purpose of the present study was to investigate the existence of @entity854 in the white matter circuit in @entity64 @entity1 and its relationship to @entity308 episodes. To target the prevention of @entity308 , we also investigated the relationship between lymphocyte subsets and @entity75 in @entity1 . METHODS: @entity1 included 18 @entity1 with acute @entity385 and 22 healthy control subjects. Diffusion tensor imaging was performed. Whole-brain voxel-based analysis was used to compare fractional anisotropy (FA) between groups. Blood samples were obtained, and the lymphocyte subsets were evaluated using flow cytometry. Follow-up examinations were conducted on 12 @entity1 at 6 months. RESULTS: FA was decreased in the bilateral anterior limb of the internal capsule in @entity64 @entity1 . At the 6-month follow-up examination, there was a significant increase in FA, which was associated with a lower @entity308 scale score. @entity1 showed a decreased percentage of circulated regulatory T lymphocytes, and the degree of reduction was related to the decrease in the FA value in the internal capsule. CONCLUSIONS: FA reductions in the anterior limb of the internal capsule cause @entity2122 and confer a biological vulnerability, which in combination with environmental stressors results in the onset of @entity308 . Our findings also demonstrated the possibility of preventing @entity64 by targeting the role of regulatory T lymphocytes in brain tissue repair and regeneration after @entity64 .

title: @entity854 in white matter, regulatory T lymphocytes, and @entity308 after XXXX .

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: BACKGROUND: The purpose of the present study was to investigate the existence of @entity854 in the white matter circuit in @entity64 @entity1 and its relationship to @entity308 episodes. To target the prevention of @entity308 , we also investigated the relationship between lymphocyte subsets and @entity75 in @entity1 . METHODS: @entity1 included 18 @entity1 with acute @entity385 and 22 healthy control subjects. Diffusion tensor imaging was performed. Whole-brain voxel-based analysis was used to compare fractional anisotropy (FA) between groups. Blood samples were obtained, and the lymphocyte subsets were evaluated using flow cytometry. Follow-up examinations were conducted on 12 @entity1 at 6 months. RESULTS: FA was decreased in the bilateral anterior limb of the internal capsule in @entity64 @entity1 . At the 6-month follow-up examination, there was a significant increase in FA, which was associated with a lower @entity308 scale score. @entity1 showed a decreased percentage of circulated regulatory T lymphocytes, and the degree of reduction was related to the decrease in the FA value in the internal capsule. CONCLUSIONS: FA reductions in the anterior limb of the internal capsule cause @entity2122 and confer a biological vulnerability, which in combination with environmental stressors results in the onset of @entity308 . Our findings also demonstrated the possibility of preventing @entity64 by targeting the role of regulatory T lymphocytes in brain tissue repair and regeneration after @entity64 .

title: @entity854 in white matter, regulatory T lymphocytes, and XXXX after @entity64 .

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']


abstract: BACKGROUND: Endocrine disrupting chemicals (EDCs) present in the environment may disrupt thyroid hormones, which in early life are essential for brain development. Observational studies regarding this topic are still limited, however as the presence of chemicals in the environment is ubiquitous, further research is warranted. The objective of the current study was to assess the association between exposure markers of various EDCs and thyroxine (T4) levels in newborns in a mother- @entity1 cohort in the Netherlands. METHODS: Exposure to @entity5980 ( @entity5980 ), three @entity5248 ( @entity5248 ) metabolites, @entity15213 ( @entity15213 ), polychlorinated biphenyl ( @entity5241 )-153, @entity14911 ( @entity14912 ), and @entity2206 ( @entity2207 ) was determined in cord plasma or breast milk, and information on T4 levels in heel prick blood spots was obtained through the neonatal screening programme in the Netherlands. Linear regression models were composed to determine associations between each of the compounds and T4, which were stratified for gender and adjusted for a priori defined covariates. RESULTS: Mean T4 level was 86.9 nmol/L (n = 83). @entity1 in the highest quartile of @entity5980 and @entity2207 exposure showed an increased T4 level compared to the lowest quartile with both crude and fully adjusted models ( @entity5980 > 107.50 ng/L, +24.8 nmol/L, 95% CI 0.79, 48.75; @entity2207 > 1200 ng/L, +38.6 nmol/L, 95% CI 13.34, 63.83). In @entity1 a lower T4 level was seen in the second quartile of exposure for both @entity14912 and @entity2207 , however after fully adjusting the models these associations were attenuated. No effects were observed for the other compounds. CONCLUSION: @entity5980 and perfluorinated alkyl acids may be associated with T4 in a sex-specific manner. These results should however be interpreted with caution, due to the relatively small study population. More research is warranted, as studies on the role of environmental contaminants in this area are still limited.

title: Prenatal exposure to endocrine disrupting chemicals in relation to thyroid hormone levels in XXXX - a Dutch prospective cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['boys', 'child', 'Girls']

entities_list: @entity15213 :: ('MESH:D006581', 'Chemical') :: ['HCB', 'hexachlorobenzene']

entities_list: @entity14911 :: ('MESH:C076994', 'Chemical') :: ['perfluorooctanesulfonic acid']

entities_list: @entity2206 :: ('MESH:C023036', 'Chemical') :: ['perfluorooctanoic acid']

entities_list: @entity5248 :: ('MESH:D004051', 'Chemical') :: ['di-2-ethylhexyl phthalate', 'DEHP']

entities_list: @entity5980 :: ('MESH:D003633', 'Chemical') :: ['dichlorodiphenyldichloroethylene', 'DDE']

answer: @entity1 :: (9606,Species) :: ['infants']


abstract: UNASSIGNED: Abstract Purpose: A port-a-cath is a device implanted under the skin for continuous drug administration. It is composed of a catheter and a @entity1346 or metal reservoir. A simulation study was done to assess the impact of a port-a-cath implant on the quality of superficial @entity221 treatments applied using the Lucite cone applicator (LCA). Methods: Specific absorption rate (SAR) and temperature distributions were predicted using SEMCAD-X (version 14.8). We simulated 72 arrangements: two LCA-implant set-ups (central port-a-cath or at an edge below the LCA footprint), six translations of the LCA per set-up, two LCA orientations (Parallel or perpendicular electric field direction) per set-up, two implant materials ( @entity6619 or metal) and a control without port-a-cath. Treatment quality was quantified by the average 1   g SAR coverage (CV25%), i.e. volume within the 25% iso-SAR surface, and the volume within the 40     C iso-temperature surface (CV40     C). Results: CV25% reduced with a @entity6619 port-a-cath located below the LCA footprint. In the worst scenario, only 64% of the CV25% of the control set-up was achieved. For a metal port-a-cath below the LCA aperture, dramatic reductions of CV25% were predicted: worst scenario down to 12.1% of the control CV25%. For the CV40     C the worst case values were 74.5% and 6.5%, for @entity6619 and metal implants, respectively. Conclusions: A @entity1346 port-a-cath below the LCA had a smaller effect on treatment quality than a metal implant. Based on this study we recommend verifying heating quality by 3D @entity1 -specific treatment planning when a port-a-cath is located below the footprint of the applicator.

title: Impact of XXXX and metal port-a-cath implants on superficial @entity221 treatment quality.

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']

answer: @entity1346 :: (MESH:D012828,Chemical) :: ['silicone']


abstract: UNASSIGNED: Abstract Purpose: A port-a-cath is a device implanted under the skin for continuous drug administration. It is composed of a catheter and a @entity1346 or metal reservoir. A simulation study was done to assess the impact of a port-a-cath implant on the quality of superficial @entity221 treatments applied using the Lucite cone applicator (LCA). Methods: Specific absorption rate (SAR) and temperature distributions were predicted using SEMCAD-X (version 14.8). We simulated 72 arrangements: two LCA-implant set-ups (central port-a-cath or at an edge below the LCA footprint), six translations of the LCA per set-up, two LCA orientations (Parallel or perpendicular electric field direction) per set-up, two implant materials ( @entity6619 or metal) and a control without port-a-cath. Treatment quality was quantified by the average 1   g SAR coverage (CV25%), i.e. volume within the 25% iso-SAR surface, and the volume within the 40     C iso-temperature surface (CV40     C). Results: CV25% reduced with a @entity6619 port-a-cath located below the LCA footprint. In the worst scenario, only 64% of the CV25% of the control set-up was achieved. For a metal port-a-cath below the LCA aperture, dramatic reductions of CV25% were predicted: worst scenario down to 12.1% of the control CV25%. For the CV40     C the worst case values were 74.5% and 6.5%, for @entity6619 and metal implants, respectively. Conclusions: A @entity1346 port-a-cath below the LCA had a smaller effect on treatment quality than a metal implant. Based on this study we recommend verifying heating quality by 3D @entity1 -specific treatment planning when a port-a-cath is located below the footprint of the applicator.

title: Impact of @entity1346 and metal port-a-cath implants on superficial XXXX treatment quality.

answer: @entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']


abstract: UNASSIGNED: The prognosis of @entity1582 is mainly dependent upon chromosomal changes. The two major abnormalities driving poor outcome are the del(17p) and the t(4;14). However, the outcome of these high-risk @entity1 is not absolutely uniform, some @entity1 presenting long survival. We hypothesized that these better outcomes might be related to concomitant "good risk" chromosomal changes exploring hyperdiploidy. We analyzed a large series of 965 @entity1582 @entity1 including 168 @entity1 with t(4;14) and 126 @entity1 with del(17p) using high throughput SNP arrays after plasma cell sorting. As expected, trisomic chromosomes were highly associated. Using the LASSO model, we found that only chromosome 3 when trisomic was associated with a longer progression free survival and that three trisomies modulated @entity1349 ( @entity1349 ) in @entity1582 @entity1 : Trisomies 3 and 5 significantly improved @entity1349 , and trisomy 21 worsened @entity1349 . Especially in @entity1 with t(4;14), trisomies 3 and/or 5 seemed to overcome the poor prognosis. For the first time, using a specific modelling approach, we show that not all trisomies display the same prognostic impact. This finding could be important for routine assessment of prognosis in @entity1582 , some high-risk @entity1 with a traditional evaluation could be in fact standard risk.

title: Understanding the role of hyperdiploidy in XXXX prognosis: which trisomies really matter?

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'myeloma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['myeloma']


abstract: Limbal epithelial stem cells (LESC) residing at the corneal periphery are largely responsible for maintaining corneal optical transparency by continuously supplying new corneal epithelial cells, which mature during their radial migration to the central @entity267 . @entity6 ( @entity6 ) affects all the structures of the eye including the @entity267 . Frequent @entity30683 , delayed wound @entity446 , and microbial infections are common alterations of the @entity6 eye that can result in @entity1018 . MicroRNAs (miRNAs) are short non-coding oligonucleotides that regulate gene expression by repressing translation. Our purpose was to understand the role of @entity6991 in the @entity1 limbal versus central corneal epithelial compartment in normal and pathological conditions such as @entity6 . Using quantitative real-time PCR (QPCR) we found @entity6991 enrichment in the limbal corneal compartment. This miRNA was also expressed at higher levels in the @entity6 vs. normal limbus. Cell migration and wound closure were significantly delayed in normal and @entity6 primary limbal epithelial cells (LEC) transfected with @entity6991 . Cells treated with @entity6991 had decreased levels of phosphorylated (activated) @entity1435 and @entity470 , mediators of epithelial wound @entity446 . Conversely, inhibition of @entity6991 significantly enhanced cell migration in both normal and @entity6 primary LEC and in @entity6 organ-cultured corneas by nearly 40% vs. scrambled miRNA control, accompanied by increased phosphorylated signaling intermediates. Transfection of @entity6991 in cultured LEC resulted in an increased immunoreactivity for putative LEC markers Frizzled-7 and K15, whereas inhibition of @entity6991 decreased their expressions. These data suggest that @entity6991 plays a role in LEC maintenance at the corneal periphery, and its expression is downregulated during their migration towards the central @entity267 and accompanying terminal differentiation. Furthermore, abnormal @entity6991 upregulation may be an important mechanism of delayed wound @entity6 .

title: Targeting XXXX to Treat Delayed Wound Healing in @entity1 Diabetic Organ-Cultured Corneas.

entities_list: @entity1018 :: ('MESH:D054062', 'Disease') :: ['vision loss']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'healing in the diabetic cornea', 'Diabetes mellitus', 'DM', 'diabetes mellitus']

entities_list: @entity30683 :: ('MESH:C565155', 'Disease') :: ['epithelial erosions']

answer: @entity6991 :: (406938,Gene) :: ['miR-146a']


abstract: Limbal epithelial stem cells (LESC) residing at the corneal periphery are largely responsible for maintaining corneal optical transparency by continuously supplying new corneal epithelial cells, which mature during their radial migration to the central @entity267 . @entity6 ( @entity6 ) affects all the structures of the eye including the @entity267 . Frequent @entity30683 , delayed wound @entity446 , and microbial infections are common alterations of the @entity6 eye that can result in @entity1018 . MicroRNAs (miRNAs) are short non-coding oligonucleotides that regulate gene expression by repressing translation. Our purpose was to understand the role of @entity6991 in the @entity1 limbal versus central corneal epithelial compartment in normal and pathological conditions such as @entity6 . Using quantitative real-time PCR (QPCR) we found @entity6991 enrichment in the limbal corneal compartment. This miRNA was also expressed at higher levels in the @entity6 vs. normal limbus. Cell migration and wound closure were significantly delayed in normal and @entity6 primary limbal epithelial cells (LEC) transfected with @entity6991 . Cells treated with @entity6991 had decreased levels of phosphorylated (activated) @entity1435 and @entity470 , mediators of epithelial wound @entity446 . Conversely, inhibition of @entity6991 significantly enhanced cell migration in both normal and @entity6 primary LEC and in @entity6 organ-cultured corneas by nearly 40% vs. scrambled miRNA control, accompanied by increased phosphorylated signaling intermediates. Transfection of @entity6991 in cultured LEC resulted in an increased immunoreactivity for putative LEC markers Frizzled-7 and K15, whereas inhibition of @entity6991 decreased their expressions. These data suggest that @entity6991 plays a role in LEC maintenance at the corneal periphery, and its expression is downregulated during their migration towards the central @entity267 and accompanying terminal differentiation. Furthermore, abnormal @entity6991 upregulation may be an important mechanism of delayed wound @entity6 .

title: Targeting @entity6991 to Treat Delayed Wound Healing in XXXX Diabetic Organ-Cultured Corneas.

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: UNASSIGNED: Inorganic carbon (Ci) is the major sink for photosynthetic reductant in organisms capable of oxygenic photosynthesis. In the absence of abundant Ci, the cyanobacterium @entity324 expresses a high affinity Ci acquisition system, the @entity3883 ( @entity3883 ), controlled by the transcriptional regulator CcmR and the metabolites NADP(+) and a-ketoglutarate, which act as co-repressors of CcmR by modulating its DNA binding. The @entity3883 thus responds to internal cellular redox changes during the transition from Ci-replete to Ci-limited conditions. However, the actual changes in the metabolic state of the NADPH/NADP(+) system that occur during the transition to Ci-limited conditions remain ill-defined. Analysis of changes in the redox state of cells experiencing Ci limitation reveals systematic changes associated with physiological adjustments and a trend towards the quinone and NADP pools becoming highly reduced. A rapid and persistent increase in F0 was observed in cells reaching the Ci-limited state, as was the induction of photoprotective fluorescence quenching. Systematic changes in the fluorescence induction transients were also observed. As with Chl fluorescence, a transient reduction of the NADPH pool ('M' peak), is assigned to State 2 > State 1 transition associated with increased electron flow to NADP(+). This was followed by a characteristic decline, which was abolished by Ci limitation or inhibition of the Calvin-Benson-Bassham (CBB) cycle and is thus assigned to the activation of the CBB cycle. The results are consistent with the proposed regulation of the @entity3883 and provide new information on the nature of the Chl and NADPH fluorescence induction curves.

title: Redox changes accompanying inorganic carbon limitation in XXXX .

entities_list: @entity3883 :: ('MESH:D041781', 'Disease') :: ['CO2-concentrating mechanisms', 'CCM']

entities_list: @entity324 :: ('1148', 'Species') :: ['Synechocystis sp. strain PCC6803']

answer: @entity324 :: (1148,Species) :: ['Synechocystis sp. PCC 6803']


abstract: Introduction_#8200;: Buruli @entity1066 (BU) is an @entity166 caused by @entity7663 . Benin, one of the most severely affected countries, notified 365  cases in 2012. This article presents the results of a psychosocial and behavioural survey conducted in the  context of a @entity283 ( @entity283 ) project with community participation. This paper  describes the diagnosis, prevention, behaviours, as well as perceptions and experiences related to BU. Methods_#8200;: A cross-sectional study was conducted in two villages (Azonme, Houedota) of Benin Atlantic department. From 15 May to 19 June 2011, a volunteer survey was conducted with 15 former @entity1 and 15 new @entity1 , selected by purposive sampling and 30 randomly selected healthy individuals. Encoding and data analysis were performed with SPSS and Excel. Results_#8200;: Respondents were aged 11 to 100 years with a mean age of 36.63 years and 55_#8200;% were @entity1 . More than 96_#8200;% of respondents were aware of BU (symptoms, mode of transmission, prevention and treatment). 20_#8200;% were familiar with the mode of transmission, but were not aware of preventive measures. Twenty-none of the 30 @entity1 or former @entity1 were treated in hospital. The attributed and perceived (including non-medical) causes of the disease were water (52), bacteria (17), @entity1835 luck (5). 92_#8200;% of respondents were satisfied with the services of health professionals but proposed changes (46) concerning hospital accessibility and cost of care. Discussion_#8200;: These results show similarities and differences compared to those reported in the literature on the subject. These surveys were the basis for @entity283 interventions with the participation of two communities.

title: [Health promotion and community-based approach to Buruli XXXX : results of a psychosocial- and behavioural survey in two villages in Benin].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity283 :: ('OMIM:603663', 'Disease') :: ['HP', 'health promotion']

entities_list: @entity7663 :: ('1809', 'Species') :: ['Mycobacterium ulcerans']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']

answer: @entity1066 :: (MESH:D014456,Disease) :: ['ulcer']


abstract: UNASSIGNED: The authors examined the state of @entity1 suffering from @entity1614 ( @entity1614 ) who endured operation for ascending @entity439 with replacement of the ascending aorta and aortic valve (Bentall operation), studying alterations of the skeleton, face, heart and eyes, as well as pathomorphological restructurings in the aortic wall. The study was carried out 7.0  4.2 years after the operation. We examined a total of 39 @entity1 with @entity1614 - 27 (69.2%) @entity1 and 12 (30.8%) @entity1 aged from 22 to 70 years old (average age - 42.1  13.4 years). All @entity1 were operated on for dissecting @entity439 of the ascending aorta accompanied by a considerable degree of @entity337 or @entity472 . The mean diameter of the aorta at the level of the sinuses of Valsalva amounted to 7.0  1.3 cm (minimal - 5.0 cm, maximal - 12.0 cm), the Z-score prior to operation was 12.7  6.5. The time form making the diagnosis of @entity1614 to surgical intervention for @entity449 amounted to 9.6  5.9 years. The condition after operative treatment in all @entity1 was satisfactory, with the haemodynamic indices stable: systolic AP - 133.5  19.1 mm Hg, diastolic AP 85.1  12.9 mm Hg, heart rate 74.8  7.2 bpm. The average systemic score for the symptoms and tests of @entity1614 @entity1 amounted to 8.2  3.3 points. Pathohistological alterations of the aorta in @entity1 with @entity1614 consisted in pronounced restructuring of the wall with deep irreversible alternative changes. The pathological process extended in the middle aortic layer all alone the length, but not only in the portions of @entity397 and dissection. The main pathomorphological signs in @entity1614 were as follows: focal accumulations of mucoid substances, dystrophic alterations of smooth-muscle cells, ribbon-like anuclear zones, formation of cystlike cavities, alterations of elastic fibres - fragmentation, hyperelastosis, multiplication, thinning and straightening, zones of elastolysis.

title: [ XXXX : clinical and pathomorphological restructurings after surgical treatment of @entity449 .]

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysm']

entities_list: @entity1614 :: ('MESH:D008382', 'Disease') :: ['MS', 'Marfan syndrome']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aorta aneurysm', 'aneurysm']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic valve insufficiency']

entities_list: @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic ostium stenosis']

answer: @entity1614 :: (MESH:D008382,Disease) :: ['Marfan syndrome']


abstract: UNASSIGNED: The authors examined the state of @entity1 suffering from @entity1614 ( @entity1614 ) who endured operation for ascending @entity439 with replacement of the ascending aorta and aortic valve (Bentall operation), studying alterations of the skeleton, face, heart and eyes, as well as pathomorphological restructurings in the aortic wall. The study was carried out 7.0  4.2 years after the operation. We examined a total of 39 @entity1 with @entity1614 - 27 (69.2%) @entity1 and 12 (30.8%) @entity1 aged from 22 to 70 years old (average age - 42.1  13.4 years). All @entity1 were operated on for dissecting @entity439 of the ascending aorta accompanied by a considerable degree of @entity337 or @entity472 . The mean diameter of the aorta at the level of the sinuses of Valsalva amounted to 7.0  1.3 cm (minimal - 5.0 cm, maximal - 12.0 cm), the Z-score prior to operation was 12.7  6.5. The time form making the diagnosis of @entity1614 to surgical intervention for @entity449 amounted to 9.6  5.9 years. The condition after operative treatment in all @entity1 was satisfactory, with the haemodynamic indices stable: systolic AP - 133.5  19.1 mm Hg, diastolic AP 85.1  12.9 mm Hg, heart rate 74.8  7.2 bpm. The average systemic score for the symptoms and tests of @entity1614 @entity1 amounted to 8.2  3.3 points. Pathohistological alterations of the aorta in @entity1 with @entity1614 consisted in pronounced restructuring of the wall with deep irreversible alternative changes. The pathological process extended in the middle aortic layer all alone the length, but not only in the portions of @entity397 and dissection. The main pathomorphological signs in @entity1614 were as follows: focal accumulations of mucoid substances, dystrophic alterations of smooth-muscle cells, ribbon-like anuclear zones, formation of cystlike cavities, alterations of elastic fibres - fragmentation, hyperelastosis, multiplication, thinning and straightening, zones of elastolysis.

title: [ @entity1614 : clinical and pathomorphological restructurings after surgical treatment of XXXX .]

answer: @entity449 :: (MESH:D001014,Disease) :: ['aortic aneurysm']


abstract: OBJECTIVE: To evaluate the role of the combined periodontic-orthodontic treatment in the esthetic reconstruc- tion of the anterior teeth area following periodontitis. METHODS: Thirteen adult @entity1 with @entity1347 were treated. The probing @entity5951 ( @entity5951 ; 102 teeth, 612 sites), @entity548 on probing (102 teeth, 204 sites), papilla index (PI; 128 papillae), and papillary height (PH; 128 papillae) of each @entity1 were assessed at baseline, 3 months after the initial therapy, and the end of the orthodontic treatment. Non-parametric and paired-sample t tests were carried out for the statistical analysis of the data. RESULTS: Three months after initial therapy, the sites with @entity5951  <= 3 mm accounted for 79.58% (487/612) of the observed teeth, and 88.73% (181/204) of the buccal and lingual sites of the teeth showed negative @entity548 on probing. These findings were better than those at baseline [26.31% (161/612) and 22.06% (45/204), respectively] (P < 0.05), but no sig- nificant difference was observed compared with pro-orthodontic treatment (P > 0.05). Prior to orthodontic treatment, the levels of the PI of 8 and 21 papillae were III and II, respectively, among the 128 observed papillae. After the orthodontic treatment, 51 papillae were at level III and 68 papillae were at level II. The PH of the 102 papillae was 2.84 mm    0.62 mm after ortho- dontic treatment. This result indicated significant difference compared with that of pre-orthodontic treatment (1.69 mm    0.57 mm) (P < 0.05). CONCLUSION: After initial therapy, moderate orthodontic teeth movements may reconstruct the interproximal soft tissue, with esthetic improvement of the papillary level and resolution of the periodontal defects.

title: [Esthetic reconstruction of the anterior teeth area following a combined periodontic-orthodontic treatment in adult periodontal XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['anterior teeth displacements']

entities_list: @entity5951 :: ('MESH:D005888', 'Disease') :: ['PD', 'pocket depth']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity2440 , @entity4729 , @entity4731 , proliferation cell nuclear antigen ( @entity1364 ), Ki67 and @entity5962 in @entity1 with @entity356 ( @entity356 ) by immunohistochemistry. A total of 69 @entity1 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity1 with @entity356 . Only positive expression of @entity4729 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity4729 (p  =  0.043), @entity1364 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity1 with @entity5962 reduced expression (p  =  0.022). But only @entity1364 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity3012 and co-expression of proteins. There was a remarkable difference between DFS or @entity3012 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity5962 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity356 @entity1 . These findings provide evidence that combined evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 may be a more powerful prognostic factor to predict relapse and distant @entity3 for @entity1 with @entity356 .

title: Prognostic evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 expression in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer', 'GC']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity2440 , @entity4729 , @entity4731 , proliferation cell nuclear antigen ( @entity1364 ), Ki67 and @entity5962 in @entity1 with @entity356 ( @entity356 ) by immunohistochemistry. A total of 69 @entity1 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity1 with @entity356 . Only positive expression of @entity4729 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity4729 (p  =  0.043), @entity1364 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity1 with @entity5962 reduced expression (p  =  0.022). But only @entity1364 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity3012 and co-expression of proteins. There was a remarkable difference between DFS or @entity3012 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity5962 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity356 @entity1 . These findings provide evidence that combined evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 may be a more powerful prognostic factor to predict relapse and distant @entity3 for @entity1 with @entity356 .

title: Prognostic evaluation of XXXX , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 expression in @entity356 .

answer: @entity2440 :: (79923,Gene) :: ['Nanog']


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity2440 , @entity4729 , @entity4731 , proliferation cell nuclear antigen ( @entity1364 ), Ki67 and @entity5962 in @entity1 with @entity356 ( @entity356 ) by immunohistochemistry. A total of 69 @entity1 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity1 with @entity356 . Only positive expression of @entity4729 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity4729 (p  =  0.043), @entity1364 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity1 with @entity5962 reduced expression (p  =  0.022). But only @entity1364 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity3012 and co-expression of proteins. There was a remarkable difference between DFS or @entity3012 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity5962 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity356 @entity1 . These findings provide evidence that combined evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 may be a more powerful prognostic factor to predict relapse and distant @entity3 for @entity1 with @entity356 .

title: Prognostic evaluation of @entity2440 , @entity4729 , XXXX , @entity1364 , Ki67 and @entity5962 expression in @entity356 .

answer: @entity4731 :: (6657,Gene) :: ['Sox2']


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity2440 , @entity4729 , @entity4731 , proliferation cell nuclear antigen ( @entity1364 ), Ki67 and @entity5962 in @entity1 with @entity356 ( @entity356 ) by immunohistochemistry. A total of 69 @entity1 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity1 with @entity356 . Only positive expression of @entity4729 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity4729 (p  =  0.043), @entity1364 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity1 with @entity5962 reduced expression (p  =  0.022). But only @entity1364 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity3012 and co-expression of proteins. There was a remarkable difference between DFS or @entity3012 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity5962 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity356 @entity1 . These findings provide evidence that combined evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 may be a more powerful prognostic factor to predict relapse and distant @entity3 for @entity1 with @entity356 .

title: Prognostic evaluation of @entity2440 , @entity4729 , @entity4731 , XXXX , Ki67 and @entity5962 expression in @entity356 .

answer: @entity1364 :: (5111,Gene) :: ['PCNA']


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity2440 , @entity4729 , @entity4731 , proliferation cell nuclear antigen ( @entity1364 ), Ki67 and @entity5962 in @entity1 with @entity356 ( @entity356 ) by immunohistochemistry. A total of 69 @entity1 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity1 with @entity356 . Only positive expression of @entity4729 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity4729 (p  =  0.043), @entity1364 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity1 with @entity5962 reduced expression (p  =  0.022). But only @entity1364 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity3012 and co-expression of proteins. There was a remarkable difference between DFS or @entity3012 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity5962 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity356 @entity1 . These findings provide evidence that combined evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 may be a more powerful prognostic factor to predict relapse and distant @entity3 for @entity1 with @entity356 .

title: Prognostic evaluation of @entity2440 , XXXX , @entity4731 , @entity1364 , Ki67 and @entity5962 expression in @entity356 .

answer: @entity4729 :: (5460,Gene) :: ['Oct4']


abstract: The purpose of this study was to evaluate expression and prognostic impact of @entity2440 , @entity4729 , @entity4731 , proliferation cell nuclear antigen ( @entity1364 ), Ki67 and @entity5962 in @entity1 with @entity356 ( @entity356 ) by immunohistochemistry. A total of 69 @entity1 were recruited who underwent gastrectomy between 2008 and 2009. We found that expression levels of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 were 26.1, 53.6, 49.3, 52.2, 60.9 and 60.9  %, respectively. Co-expression of more than any two proteins (defined as high-risk group) was detected in 43 of 69 (62.3  %) @entity1 with @entity356 . Only positive expression of @entity4729 had relationship with lymphatic invasion (p  =  0.013), and positive expression of Ki67 was correlated with T classification (p  =  0.011). Furthermore, positive expression of @entity4729 (p  =  0.043), @entity1364 (p  =  0.035) and Ki67 (p  =  0.023) was significantly associated with poor 3-year disease-free survival (DFS). The same result was detected in @entity1 with @entity5962 reduced expression (p  =  0.022). But only @entity1364 positive expression predicted poor overall survival (p  =  0.042) in univariate analysis. In addition, 3-year DFS was 20  % in high-risk group and 71  % in low-risk group. The same tendency was found between @entity3012 and co-expression of proteins. There was a remarkable difference between DFS or @entity3012 and co-expression of more than two proteins (p  =  0.000). Multivariate analysis showed that @entity5962 and co-expression were independent prognostic factors of 3-year diseases-free survival. But only co-expression of more than two markers dramatically affected the survival of @entity356 @entity1 . These findings provide evidence that combined evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and @entity5962 may be a more powerful prognostic factor to predict relapse and distant @entity3 for @entity1 with @entity356 .

title: Prognostic evaluation of @entity2440 , @entity4729 , @entity4731 , @entity1364 , Ki67 and XXXX expression in @entity356 .

answer: @entity5962 :: (999,Gene) :: ['E-cadherin']


abstract: @entity79 is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking. This study aims at improving our understanding of alveolar bone formation and the role of bone morphogenetic proteins (Bmps) in this process. @entity19 at embryonic (E) day 13.5 to @entity16843 ( @entity16843 ) day 15.5 were selected to observe the process of alveolar bone development. Alveolar bone development was found to be morphologically observable at E14.5. Molar teeth isolated from @entity19 at PN7.5 were pretreated with @entity8385 , @entity7739 , @entity13421 , or BSA, and grafted subcutaneously into @entity19 . The subcutaneously implanted tooth germs formed alveolar bone indicating the role of the dental follicle in alveolar bone development. Alveolar bone formation was increased after pretreatment with @entity8385 and @entity7739 , but not with @entity13421 . Gene expression levels in dental follicle cells from @entity19 molars were also determined by real-time RT-PCR. The expression levels of @entity2447 , @entity71720 , and Ocn were significantly higher in dental follicle cells cultured with @entity8385 or @entity7739 , and significantly lower in those cultured with @entity13421 when compared with that of the BSA controls. Our results suggest that the dental follicle participates in alveolar bone formation and @entity18435 appears to accelerate alveolar bone development.

title: @entity8385 and XXXX accelerate alveolar bone development.

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['Alveolar bone remodeling']

answer: @entity7739 :: (12159(Tax:10090),Gene) :: ['Bmp4']


abstract: @entity79 is a continuous process that takes place during development and in response to various physiological and pathological stimuli. However, detailed knowledge regarding the underlying mechanisms involved in alveolar bone development is still lacking. This study aims at improving our understanding of alveolar bone formation and the role of bone morphogenetic proteins (Bmps) in this process. @entity19 at embryonic (E) day 13.5 to @entity16843 ( @entity16843 ) day 15.5 were selected to observe the process of alveolar bone development. Alveolar bone development was found to be morphologically observable at E14.5. Molar teeth isolated from @entity19 at PN7.5 were pretreated with @entity8385 , @entity7739 , @entity13421 , or BSA, and grafted subcutaneously into @entity19 . The subcutaneously implanted tooth germs formed alveolar bone indicating the role of the dental follicle in alveolar bone development. Alveolar bone formation was increased after pretreatment with @entity8385 and @entity7739 , but not with @entity13421 . Gene expression levels in dental follicle cells from @entity19 molars were also determined by real-time RT-PCR. The expression levels of @entity2447 , @entity71720 , and Ocn were significantly higher in dental follicle cells cultured with @entity8385 or @entity7739 , and significantly lower in those cultured with @entity13421 when compared with that of the BSA controls. Our results suggest that the dental follicle participates in alveolar bone formation and @entity18435 appears to accelerate alveolar bone development.

title: XXXX and @entity7739 accelerate alveolar bone development.

answer: @entity8385 :: (12156(Tax:10090),Gene) :: ['Bmp2']


abstract: OBJECTIVES: To observe the frequency of @entity0 among Saudi @entity1 and to highlight the age variations and features of @entity5 . METHODS: A retrospective study of @entity0 biopsies from all Saudi @entity1 performed between January 2006 and December 2013 in King Fahad Hospital, Al-Madinah, Kingdom of Saudi Arabia. All the available demographic and @entity5 related data was analyzed. RESULTS: Of 1005 breast tissues reviewed, 982 specimens were from female, and 23 from male @entity1 . In females, 398 specimens (40.5%) were diagnosed as malignant. @entity513 ( @entity513 ) (85.2%) was most common, followed by @entity513 in situ (8%), and @entity1137 (2.7%). The mean age of Saudi females with @entity513 was 46.9 years. Approximately 48.7% @entity513 were @entity5 . A @entity5 size >2.5 cm   was found in 61.1% @entity1 , whereas axillary nodal @entity3 was present in 57.1% and lympho-vascular invasion in 64.1% who underwent axillary nodal dissection. In males, 4 specimens (17.4%) were malignant (all @entity513 ). CONCLUSION: Our finding are consistent with previous reports of @entity0 being diagnosed in younger age group, in advanced stages, and with features of @entity146 ; which signals the urgency for implementation of breast screening programs.

title: Histopathological features of XXXX in Al-Madinah region of Saudi Arabia.

entities_list: @entity1137 :: ('MESH:D018275', 'Disease') :: ['invasive lobular carcinoma']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive behavior']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Grade III tumors', 'advanced cancer']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma', 'IDC', 'Invasive ductal carcinoma']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: OBJECTIVE: To explore the correlation between single acupoints used and the recurrence rate of @entity2335 among @entity2335 -prone @entity1 receiving acupuncture as a prophylactic treatment. METHODS: In all, 58 @entity2335 -prone @entity1 were included in the analysis. Customised acupuncture treatments were given twice a week, over 4 weeks. The main effect parameter was the number of @entity2335 episodes during the 6-month observation time. Residual urine was measured at baseline, 2, 4 and 6 months using portable ultrasound equipment. Sympathetic and vagotone nerve activities were measured by using skin conductance and respiratory sinus @entity943 , respectively. RESULTS: The main acupoints used for @entity1 with Kidney (Shen) qi/ @entity14717 were Shenshu (BL23), Taixi (KI3), Zhongji (CV3), Sanyinjiao ( @entity8949 ) and Pangguangshu (BL28), compared with Taichong ( @entity8950 ), CV3, BL28, Yinlingquan ( @entity14447 ) and @entity8949 for Liver (Gan) qi stagnation, and @entity8949 , CV3, BL28, Zusanli (ST36) and @entity14447 for Spleen (Pi) qi/ @entity14717 @entity1 . The combination BL23 and KI3 were used in 16 @entity1 , 13 of which were Kidney pattern related @entity1 . When used, the number of symptomatic episodes were reduced to a third compared with what occurred in the 42 @entity1 where this combination was not used (3/16 vs. 28/42, P<0.05). BL23 application correlated to a significant reduction in residual urine measured a few days after treatment. @entity1 with the pattern of Spleen qi/ @entity14717 had an initial increase in residual urine after treatments. CONCLUSION: Treating Kidney pattern related @entity1 with the combination of BL23 and KI3 resulted in far better outcome than other points/combination of points for other Chinese medicine diagnoses. The acupoint @entity8949 may be less indicated than previously assumed when treating @entity2335 -prone @entity1 prophylactically.

title: Acupuncture points used in the prophylaxis against recurrent uncomplicated XXXX , patterns identified and their possible relationship to physiological measurements.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity14717 :: ('MESH:D016711', 'Disease') :: ['yang deficiency']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity2335 :: (MESH:D003556,Disease) :: ['cystitis']


abstract: OBJECTIVE: To explore the effectiveness and safety of raltitrexed/ @entity900 with concurrent radiotherapy in treating of @entity1 with @entity5 . @entity1 AND METHODS: Sixty-five @entity1 with @entity5 enrolled in this study, received raltitrexed/ @entity900 with concurrent radiotherapy. The treatment consisted of raltitrexed 3 mg/m2 iv 15 min, d1; @entity900 60 mg/m2 iv 60 min, d1, and pelvic radiotherapy, using three-dimensional conformal radiotherapy. The radiotherapy was implemented over Elekta accelerator (Model Type Precise), with 2.0 Gy per fraction for the whole pelvic or pelvic extension field. Central lead shield was used if the dose reached 30 Gy to produce a total dosage of 50 Gy. Following radiation therapies of full pelvic field or extended-field, additional radiation with the dose of 56-60 Gy was administrated to the lymph node @entity3 . Brachytherapy of iridium 192 was completed in our hospital, with the dose of 7Gy per fraction for point A, once a week, with six fractions for internal radiations during the full treatment course of eight weeks. RESULTS: A total of 65 @entity1 completed radiotherapy with two cycles of concurrent chemotherapy. Amongst them, chemotherapy was delayed for a week due to hypoleukocytosis for seven of the @entity1 . Total response rate, three-year disease-free survival, and three-year overall survival OS were 95.4%, 75.4%, and 90.7%. High-grade (>=  3) acute @entity137 were hypoleukocytosis (23.1%) and @entity882 (6.2%) with a prevalence of high-grade (>=  3) late @entity137 at 1.5%. One @entity1 received surgical resection because of a partial @entity1321 after 8 months of radiotherapy. CONCLUSIONS: Raltitrexed/ @entity900 combined with concurrent radiotherapy is effective in treating @entity5 .

title: The role of raltitrexed/ XXXX with concurrent radiation therapy in treating @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['advanced cervical cancer', 'stage IIB-IVA cervical cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['cisplatin']


abstract: OBJECTIVE: To explore the effectiveness and safety of raltitrexed/ @entity900 with concurrent radiotherapy in treating of @entity1 with @entity5 . @entity1 AND METHODS: Sixty-five @entity1 with @entity5 enrolled in this study, received raltitrexed/ @entity900 with concurrent radiotherapy. The treatment consisted of raltitrexed 3 mg/m2 iv 15 min, d1; @entity900 60 mg/m2 iv 60 min, d1, and pelvic radiotherapy, using three-dimensional conformal radiotherapy. The radiotherapy was implemented over Elekta accelerator (Model Type Precise), with 2.0 Gy per fraction for the whole pelvic or pelvic extension field. Central lead shield was used if the dose reached 30 Gy to produce a total dosage of 50 Gy. Following radiation therapies of full pelvic field or extended-field, additional radiation with the dose of 56-60 Gy was administrated to the lymph node @entity3 . Brachytherapy of iridium 192 was completed in our hospital, with the dose of 7Gy per fraction for point A, once a week, with six fractions for internal radiations during the full treatment course of eight weeks. RESULTS: A total of 65 @entity1 completed radiotherapy with two cycles of concurrent chemotherapy. Amongst them, chemotherapy was delayed for a week due to hypoleukocytosis for seven of the @entity1 . Total response rate, three-year disease-free survival, and three-year overall survival OS were 95.4%, 75.4%, and 90.7%. High-grade (>=  3) acute @entity137 were hypoleukocytosis (23.1%) and @entity882 (6.2%) with a prevalence of high-grade (>=  3) late @entity137 at 1.5%. One @entity1 received surgical resection because of a partial @entity1321 after 8 months of radiotherapy. CONCLUSIONS: Raltitrexed/ @entity900 combined with concurrent radiotherapy is effective in treating @entity5 .

title: The role of raltitrexed/ @entity900 with concurrent radiation therapy in treating XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['advanced cervical cancer']


abstract: BACKGROUND: General practitioners (GPs) play crucial roles in early detection of @entity1489 . A pilot-study found a positive short-term effect of a 1-day dermatologic education programme on GPs' diagnostic competence. OBJECTIVE: To determine effects of a multifaceted intervention, including technical equipment and continuing feedback by a dermatologist, on GPs' diagnostic skills regarding @entity1489 . METHODS: Randomized controlled trial with 78 GPs of the Canton of Zurich, Switzerland. INTERVENTION: GPs in intervention group received a 1-day training, a Lumio(  ) (magnifying glass with polarized light, 3Gen), a Nikon digital camera and - during 1  year - feedback on @entity272 pictures sent to the dermatologist. GPs in control group only received the 1-day training. MAIN OUTCOME AND MEASURES: Primary outcome: structured assessment of GP's diagnostic skills in correctly diagnosing images of @entity272 regarding @entity1489 . At baseline prior to intervention (T0), after the full-day training course in both groups (T1), and after 1  year of continuing feedback (T2) to the intervention group. MEASURES: Non-parametric unpaired (Wilcoxon-Mann-Whitney) tests were used to compare numbers of correctly classified @entity272 between both groups at T2 and for the change between T1 and T2. RESULTS: At T0, both groups classified a median of 23 @entity272 of the 36 images correctly. This value rose to 28 for both groups at T1 and fell to 24 for both groups at T2. No difference between control and intervention group at T2. Furthermore, we compared differences in the sum scores per GP between T1 and T2 for each group. Also in this comparison, no difference between control and intervention group was found. CONCLUSION AND RELEVANCE: No long-term effect of the multifaceted intervention was found on the competence to diagnose @entity1489 by GPs. The positive short-term effect of the 1-day dermatologic education programme did not persist over 12  months.

title: A multifaceted intervention: no increase in general practitioners' competence to diagnose XXXX (minSKIN) - randomized controlled trial.

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancer']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesion', 'skin lesions']

answer: @entity1489 :: (MESH:D012878,Disease) :: ['skin cancer']


abstract: To study the influence of particle size on drug efficacy and other properties, a series of @entity1499 intercalated layered double @entity15680 ( @entity1500 /LDHs) were synthesized through the traditional coprecipitation method, using a mixture of water and @entity968 ( @entity968 ) as the solvent. To adjust the particle size of @entity1500 /LDHs, the dropping way, the volume ratio of water to @entity968 and different hydrothermal treatment time changed accordingly, and the results indicate that the particle size can be controlled between 90 and 140nm. @entity2195 and inductive coupled plasma (ICP) analysis indicated that different synthesis conditions almost have no effect on the compositions of the nanohybrids. X-ray diffraction (XRD) patterns manifested the successful intercalation of @entity1500 anions into the LDH interlayers, and it's also found out that different volume ratios of water to @entity968 and variable dropping way can affect the crystallinity of the final samples, i.e., the volume ratio of 3:1 and pH decreasing are proved to be optimum conditions. Furthermore, both antiparallel monolayer and bilayers adopting different orientations are suggested for four samples from XRD results. Fourier transform infrared spectroscopy (FTIR) investigations proved the coexistence of @entity6445 and @entity1500 anions in the interlayer of the nanohybrids. @entity1500 /LDH particles exhibited hexagonal platelet morphology with round corner and different dropping ways can affect the morphology greatly. Moreover, a DSC study indicated that longer time treatment can weaken the bond between the @entity1500 anions and LDH layers. The kinetic release profiles told us that larger @entity1500 /LDH particles have enhanced the ability of LDH layers to protect interlayer molecules. At last, the bioassay study indicated that the nanohybrids with larger diameters have higher @entity5 suppression efficiency.

title: Facile synthesis of XXXX intercalated layered double @entity15680 : Particle control, structure and bioassay explore.

entities_list: @entity15680 :: ('MESH:D006878', 'Chemical') :: ['hydroxides']

entities_list: @entity2195 :: ('OMIM:211750', 'Disease') :: ['Elemental C/H/N']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity968 :: ('MESH:D011092', 'Chemical') :: ['polyethylene glycol', 'PEG-400']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: To study the influence of particle size on drug efficacy and other properties, a series of @entity1499 intercalated layered double @entity15680 ( @entity1500 /LDHs) were synthesized through the traditional coprecipitation method, using a mixture of water and @entity968 ( @entity968 ) as the solvent. To adjust the particle size of @entity1500 /LDHs, the dropping way, the volume ratio of water to @entity968 and different hydrothermal treatment time changed accordingly, and the results indicate that the particle size can be controlled between 90 and 140nm. @entity2195 and inductive coupled plasma (ICP) analysis indicated that different synthesis conditions almost have no effect on the compositions of the nanohybrids. X-ray diffraction (XRD) patterns manifested the successful intercalation of @entity1500 anions into the LDH interlayers, and it's also found out that different volume ratios of water to @entity968 and variable dropping way can affect the crystallinity of the final samples, i.e., the volume ratio of 3:1 and pH decreasing are proved to be optimum conditions. Furthermore, both antiparallel monolayer and bilayers adopting different orientations are suggested for four samples from XRD results. Fourier transform infrared spectroscopy (FTIR) investigations proved the coexistence of @entity6445 and @entity1500 anions in the interlayer of the nanohybrids. @entity1500 /LDH particles exhibited hexagonal platelet morphology with round corner and different dropping ways can affect the morphology greatly. Moreover, a DSC study indicated that longer time treatment can weaken the bond between the @entity1500 anions and LDH layers. The kinetic release profiles told us that larger @entity1500 /LDH particles have enhanced the ability of LDH layers to protect interlayer molecules. At last, the bioassay study indicated that the nanohybrids with larger diameters have higher @entity5 suppression efficiency.

title: Facile synthesis of @entity1499 intercalated layered double XXXX : Particle control, structure and bioassay explore.

answer: @entity15680 :: (MESH:D006878,Chemical) :: ['hydroxides']


abstract: Different explants of fenugreek, T. foenum-graecum L. (Var. RMt-303), were compared for their callus induction and subsequent shoot regeneration capabilities on Murashige and Skoog media supplemented with different phytohormones in varying concentration. The highest percentage of callus induction frequency was observed in 1 ppm @entity40404 ( @entity3015 ). Maximum shoots were induced on media supplemented with 0.5 ppm BAP using leaf and stem tissues as explants. However, root tissues showed only callusing with no subsequent shooting. Cotyledonary node responded better than hypocotyls in terms of shoot induction on media supplemented with @entity30972 (0.1 ppm). The callus was subjected to drought stress as simulated by reduced water potential of growth media due to addition of @entity2656 . Calli could withstand -2 MPa water potential till 30 days indicating that the drought stress tolerance mechanisms are functional in this variety. Chlorophyll a and b and total @entity38 , @entity1521 and total phenolic contents, total peroxidase and catalase activities increased under stress conditions suggesting the tolerance of callus to drought stress. However, @entity9050 peroxidase, @entity12682 peroxidase activities were found to decrease slightly. @entity1234 and @entity274 contents were found to decrease while only a slight disturbance was found in membrane stability index. These results underline the mechanisms that are crucial for drought stress tolerance in fenugreek.

title: XXXX -induced drought stress on calli of Trigonellafoenum-graecum L. Var. RMt-303.

entities_list: @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol']

entities_list: @entity30972 :: ('MESH:C016785', 'Chemical') :: ['thidiazuron']

entities_list: @entity40404 :: ('MESH:C480551', 'Chemical') :: ['benzylaminopurine']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['Malondialdehyde']

entities_list: @entity1521 :: ('CHEBI:26271', 'Chemical') :: ['proline']

entities_list: @entity38 :: ('MESH:D002734', 'Chemical') :: ['chlorophyll']

entities_list: @entity9050 :: ('CHEBI:38290', 'Chemical') :: ['ascorbate']

answer: @entity2656 :: (MESH:D008353,Chemical) :: ['Mannitol']


abstract: Forty-two percent of @entity526 and 58% of Enterococcus spp. isolated from @entity291 feedlot runoff and associated infiltration basin and constructed wetland treatment system were resistant to at least one antibiotic of clinical importance; a high level of multidrug resistance (22% of @entity526 and 37% of Enterococcus spp.) was observed. Hierarchical clustering revealed a closely associated resistance cluster among drug-resistant @entity526 isolates that included @entity2886 (ceftiofur, cefoxitin, and @entity2756 ), @entity581 ( @entity801 , @entity7913 , and @entity4509 ), and quinolone nalidixic acid; antibiotics from these classes were used at the study site, and cross-resistance may be associated with transferrable multiple-resistance elements. For Enterococcus spp., co-resistance among @entity2176 , @entity5136 , and @entity13757 was common; these antibiotics are reserved for complicated clinical infections and have not been approved for animal use. @entity2176 resistance (n   =   49) only occurred when isolates were resistant to @entity5136 , @entity13757 , and all four of the MLSB (macrolide-lincosamide-streptogramin B) antibiotics tested ( @entity8588 , @entity2929 , @entity6186 , and quinipristin/ @entity11686 ). This suggests that developing co-resistance to MLSB antibiotics along with cyclic lipopeptides and @entity32225 may result in resistance to @entity2176 as well. Effects of the treatment system on antibiotic resistance were pronounced during periods of no rainfall and low flow (long residence time). Increased hydraulic loading (short residence time) under the influence of rain caused antibiotic-resistant bacteria to be flushed through the treatment system. This presents concern for environmental discharge of multidrug-resistant organisms relevant to public health.

title: Hierarchal clustering yields insight into multidrug-resistant bacteria isolated from a XXXX feedlot wastewater treatment system.

entities_list: @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamycin']

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone']

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin', 'Vancomycin']

entities_list: @entity7913 :: ('MESH:D007612', 'Chemical') :: ['kanamycin']

entities_list: @entity11686 :: ('MESH:C113826', 'Chemical') :: ['dalfopristin']

entities_list: @entity2929 :: ('MESH:D004917', 'Chemical') :: ['erythromycin']

entities_list: @entity4509 :: ('MESH:D000583', 'Chemical') :: ['amikacin']

entities_list: @entity6186 :: ('MESH:D008034', 'Chemical') :: ['lincomycin']

entities_list: @entity2886 :: ('MESH:D002511', 'Chemical') :: ['cephalosporins']

entities_list: @entity32225 :: ('MESH:D023303', 'Chemical') :: ['oxazolidinones']

entities_list: @entity13757 :: ('MESH:D017576', 'Chemical') :: ['daptomycin']

entities_list: @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides']

entities_list: @entity5136 :: ('MESH:C098010', 'Chemical') :: ['linezolid']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity291 :: (9913,Species) :: ['cattle']