abstract: Of the 120 @entity1252 ( @entity1252 ) @entity1 treated by the authors, two have developed @entity548 . The authors' objective is to present this rare, but severe manifestation. @entity1 1 and 2 were 66- and 22-year old @entity1 , respectively. Both had @entity1252 with multi-organ involvements including diffuse proliferative @entity1988 . Before the diagnosis of the disease, both @entity1 had experienced @entity55 that resolved on corticosteroid treatment. Soon after the diagnosis, @entity1576 , haemoptoea and acute @entity417 developed, accompanied by a rapid deterioration in the general condition. Chest radiographs revealed bilateral, diffuse, alveolar infiltrates. The @entity548 temporarily ceased in response to @entity228 treatment, but both @entity1 later died in consequence of active @entity1252 and mixed @entity364 . Post mortem examination demonstrated @entity3794 and @entity548 in @entity1 1, and an immune complex deposition-induced @entity32 with @entity548 in @entity1 2. @entity548 is a life-threatening manifestation of @entity1252 . Its onset may be preceded by episodes of @entity55 resolving on corticosteroid treatment. An active diagnostic workup, intensive observation and aggressive immunosuppressive treatment are the cornerstones of the management. The early detection and the active treatment of secondary infections are obligatory. The authors consider the most difficult challenge to be the optimum coordination of the above treatment modalities.

title: [Diffuse @entity548 in XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'Patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['alveolocapillary inflammation']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['diffuse alveolar haemorrhage', 'alveolar bleeding', 'Diffuse alveolar haemorrhage', 'pulmonary haemorrhage', 'alveolar haemorrhage']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['fibrosing alveolitis']

entities_list: @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['bacterial and fungal sepsis']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']


abstract: Of the 120 @entity1252 ( @entity1252 ) @entity1 treated by the authors, two have developed @entity548 . The authors' objective is to present this rare, but severe manifestation. @entity1 1 and 2 were 66- and 22-year old @entity1 , respectively. Both had @entity1252 with multi-organ involvements including diffuse proliferative @entity1988 . Before the diagnosis of the disease, both @entity1 had experienced @entity55 that resolved on corticosteroid treatment. Soon after the diagnosis, @entity1576 , haemoptoea and acute @entity417 developed, accompanied by a rapid deterioration in the general condition. Chest radiographs revealed bilateral, diffuse, alveolar infiltrates. The @entity548 temporarily ceased in response to @entity228 treatment, but both @entity1 later died in consequence of active @entity1252 and mixed @entity364 . Post mortem examination demonstrated @entity3794 and @entity548 in @entity1 1, and an immune complex deposition-induced @entity32 with @entity548 in @entity1 2. @entity548 is a life-threatening manifestation of @entity1252 . Its onset may be preceded by episodes of @entity55 resolving on corticosteroid treatment. An active diagnostic workup, intensive observation and aggressive immunosuppressive treatment are the cornerstones of the management. The early detection and the active treatment of secondary infections are obligatory. The authors consider the most difficult challenge to be the optimum coordination of the above treatment modalities.

title: [Diffuse XXXX in @entity1252 ].

answer: @entity548 :: (MESH:D006470,Disease) :: ['alveolar hemorrhage']


abstract: OBJECTIVE: Despite evidence demonstrating that risk-factor management is effective in reducing recurrent @entity66 , there are very few structured care programmes for @entity64 survivors. The aim was to implement and evaluate an integrated care programme in @entity64 . METHODS: 186 @entity1 with @entity64 were randomised to either the treatment (integrated care) or control (usual care) group and were followed up over 12 months. The Integrated Care for the Reduction of @entity64 (ICARUSS) model of integrated care involved collaboration between a specialist @entity64 service, a hospital coordinator and a @entity1 's general practitioner. The primary aim was to promote the management of vascular risk factors through ongoing @entity1 contact and education. RESULTS: In the 12 months poststroke, systolic blood pressure (sBP) decreased in the treatment group but increased in controls. The group difference was significant, and remained so when age, sex, disability and sBP at discharge were accounted for (p = 0.04). Treatment @entity1 also exhibited better modification of body mass index (p = 0.007) and number of walks taken (p<0.001) than controls. Rankin scores indicated significantly @entity717 in treatment @entity1 relative to controls in the year poststroke (p = 0.003). CONCLUSIONS: Through an integrated system of education, advice and support to both @entity1 and GP, the ICARUSS model was effective in modifying a variety of vascular risk factors and therefore should decrease the likelihood or recurrent @entity64 or vascular event.

title: Integrated care improves risk-factor modification after XXXX : initial results of the Integrated Care for the Reduction of @entity64 model.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['reduced disability']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['Secondary Stroke', 'stroke']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: OBJECTIVE: Despite evidence demonstrating that risk-factor management is effective in reducing recurrent @entity66 , there are very few structured care programmes for @entity64 survivors. The aim was to implement and evaluate an integrated care programme in @entity64 . METHODS: 186 @entity1 with @entity64 were randomised to either the treatment (integrated care) or control (usual care) group and were followed up over 12 months. The Integrated Care for the Reduction of @entity64 (ICARUSS) model of integrated care involved collaboration between a specialist @entity64 service, a hospital coordinator and a @entity1 's general practitioner. The primary aim was to promote the management of vascular risk factors through ongoing @entity1 contact and education. RESULTS: In the 12 months poststroke, systolic blood pressure (sBP) decreased in the treatment group but increased in controls. The group difference was significant, and remained so when age, sex, disability and sBP at discharge were accounted for (p = 0.04). Treatment @entity1 also exhibited better modification of body mass index (p = 0.007) and number of walks taken (p<0.001) than controls. Rankin scores indicated significantly @entity717 in treatment @entity1 relative to controls in the year poststroke (p = 0.003). CONCLUSIONS: Through an integrated system of education, advice and support to both @entity1 and GP, the ICARUSS model was effective in modifying a variety of vascular risk factors and therefore should decrease the likelihood or recurrent @entity64 or vascular event.

title: Integrated care improves risk-factor modification after @entity64 : initial results of the Integrated Care for the Reduction of XXXX model.

answer: @entity64 :: (MESH:D020521,Disease) :: ['Secondary Stroke']


abstract: BACKGROUND/AIMS: Nutritional supplements are widely used. Recently, @entity99 after consumption of Herbalife preparations was reported but the underlying pathogenesis remained cryptic. METHODS: Two @entity1 presented with @entity1448 and @entity111 , and @entity82 , respectively. Viral, alcoholic, metabolic, autoimmune, @entity96 and synthetic drugs as the precipitating causes of @entity99 were excluded. However, both @entity1 reported long-term consumption of Herbalife products. All Herbalife products were tested for contamination with drugs, pesticides, heavy metals, and softeners, and examined for microbial contamination according to standard laboratory procedures. Bacteria isolated from the samples were identified as @entity3881 by sequencing the 16S rRNA and gyrB genes. RESULTS: Causality between consumption of Herbalife products and disease according to CIOMS was scored "probable" in both cases. Histology showed @entity1448 with @entity82 in one @entity1 , and @entity82 with ductopenia in the other. No contamination with chemicals or heavy metals was detected, and immunological testing showed no drug @entity56 . However, samples of Herbalife products ingested by both @entity1 showed growth of @entity3881 of which culture supernatants showed dose- and time-dependent hepatotoxicity. CONCLUSIONS: Two novel incidents of severe @entity99 following intake of Herbalife products contaminated with @entity3881 emphasize its potential hepatotoxicity.

title: Severe hepatotoxicity following ingestion of Herbalife nutritional supplements contaminated with XXXX .

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis', 'biliary fibrosis']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['neoplastic, vascular liver diseases']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestatic hepatitis', 'cholestatic and lobular/portal hepatitis']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['hypersensitivity']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic injury', 'liver injury']

entities_list: @entity3881 :: ('1423', 'Species') :: ['Bacillus subtilis']

answer: @entity3881 :: (1423,Species) :: ['Bacillus subtilis']


abstract: OBJECTIVES: To determine: 1) physician practices regarding the use of radiographs for @entity135 ( @entity135 ), 2) the prevalence of missed @entity174 in @entity1 with a clinical diagnosis of @entity135 , 3) the relative risk of a @entity174 with a nonclassic history for mechanism of injury for @entity135 , and 4) radiographic findings associated with @entity135 that are difficult to reduce. METHODS: This study began with a physician survey that addressed the integration of radiographs into the management of @entity135 . We subsequently conducted a prospective randomized trial with a consecutive sampling of @entity1 less than 6 years of age who presented to one of 2 urban pediatric emergency departments and 2 suburban pediatric urgent care centers with a clinical diagnosis of @entity135 . After informed consent was obtained, reduction was undertaken with a maximum of four attempts (two by hyperpronation and two by supination/flexion), 15 minutes apart. Failure to reduce the @entity135 resulted in the procurement of a radiograph of the elbow. At the conclusion of the study, all radiographs were evaluated by a radiologist blinded to the diagnosis. @entity1 receiving radiographs were contacted 2 weeks after discharge for verification of the diagnosis. RESULTS: Eighty-four percent of 224 physicians returned completed surveys. Fifty-six percent reported using radiographs for failed reduction attempts. In the second phase of the study, 136 @entity1 were enrolled prospectively: 127 were reduced successfully and 9 @entity1 failed attempts at reduction. Of the nine @entity1 receiving radiographs: four had @entity174 (prevalence of 2.9% with 95% confidence interval (CI) = 0.8-7.4), two had no radiographic findings and normal function on follow up, and three had isolated posterior fat pads on radiograph and normal function on follow-up. The relative risk of a @entity174 in @entity1 with a nonclassic history defined as any mechanism other than "pull" was 1.200 (95% CI = 0.441-3.264); the relative risk was 1.886 (95% CI = 0.680-5.231) when defining a nonclassic history as any mechanism other than "pull" or "fall." CONCLUSIONS: 1) Physicians tend to order radiographs for @entity130 they initially perceive to be @entity135 when attempts at reduction fail. 2) In our study, @entity174 in @entity1 who presented with the classic flexed elbow/pronated wrist position were rare. 3) The relative risk of a @entity174 in @entity1 with a nonclassic history for mechanism of injury was not significant. 4) An isolated finding of a posterior fat pad in a @entity1 with @entity135 that is difficult to reduce was not associated with a @entity174 in our small sample of @entity1 with radiographic findings.

title: History and radiographic findings associated with clinically suspected XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'child']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['radial head subluxations', 'RHS']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['elbow injuries']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

answer: @entity135 :: (MESH:D006258,Disease) :: ['radial head subluxations']


abstract: BACKGROUND: @entity1778 is a @entity5 characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic @entity1 can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. METHODS: This case report describes severe maxillary and mandibular necrotizing @entity3136 and @entity4034 in a young female @entity1 after chemotherapy for acute @entity1778 . On physical examination, the @entity1 presented malnourished with pale skin, cervical @entity3298 , frequent fever and generalized @entity158 . The intra-oral clinical examination found @entity7868 , multiple @entity1066 , necrotizing @entity3136 and @entity4034 located in the maxillary and mandibular regions. The necrotizing @entity3136 and @entity4034 were treated locally with atraumatic removal of the necrotized tissues. The @entity1 received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of @entity1216 . She was also treated with systemic @entity868 and @entity115 for 21 days. RESULTS: During the course of management the @entity1 's oral condition improved with some re-epithelialization being noted. However, severe alveolar @entity79 remained evident. Thirty-two months after presentation of the initial symptoms, the @entity1 died due to complications related to @entity1778 recurrence ( @entity548 , @entity295 and @entity649 ). CONCLUSIONS: Dental monitoring during @entity5 treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

title: Severe necrotizing @entity3136 and @entity4034 after chemotherapy for acute XXXX .

entities_list: @entity1216 :: ('MESH:D002710', 'Chemical') :: ['chlorhexidine']

entities_list: @entity7868 :: ('MESH:D006209', 'Disease') :: ['halitosis']

entities_list: @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis']

entities_list: @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole']

entities_list: @entity115 :: ('MESH:D000658', 'Chemical') :: ['amoxicillin']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignant neoplasm']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress syndrome']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['osteomyelitis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone destruction']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia', 'Leukaemia']

entities_list: @entity3298 :: ('MESH:D008199', 'Disease') :: ['lymphadenitis']

answer: @entity1778 :: (MESH:D007938,Disease) :: ['leukaemia']


abstract: BACKGROUND: @entity1778 is a @entity5 characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic @entity1 can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. METHODS: This case report describes severe maxillary and mandibular necrotizing @entity3136 and @entity4034 in a young female @entity1 after chemotherapy for acute @entity1778 . On physical examination, the @entity1 presented malnourished with pale skin, cervical @entity3298 , frequent fever and generalized @entity158 . The intra-oral clinical examination found @entity7868 , multiple @entity1066 , necrotizing @entity3136 and @entity4034 located in the maxillary and mandibular regions. The necrotizing @entity3136 and @entity4034 were treated locally with atraumatic removal of the necrotized tissues. The @entity1 received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of @entity1216 . She was also treated with systemic @entity868 and @entity115 for 21 days. RESULTS: During the course of management the @entity1 's oral condition improved with some re-epithelialization being noted. However, severe alveolar @entity79 remained evident. Thirty-two months after presentation of the initial symptoms, the @entity1 died due to complications related to @entity1778 recurrence ( @entity548 , @entity295 and @entity649 ). CONCLUSIONS: Dental monitoring during @entity5 treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

title: Severe necrotizing XXXX and @entity4034 after chemotherapy for acute @entity1778 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity3136 :: (MESH:D013280,Disease) :: ['stomatitis']


abstract: BACKGROUND: @entity1778 is a @entity5 characterized by clonal proliferation of white blood cells within the bone marrow. Despite an increase in the white blood cell count, the leukaemic leukocytes are non-functional. The oral complications arising in leukaemic @entity1 can be attributed to the direct and indirect effects of immunosuppressive chemotherapy. METHODS: This case report describes severe maxillary and mandibular necrotizing @entity3136 and @entity4034 in a young female @entity1 after chemotherapy for acute @entity1778 . On physical examination, the @entity1 presented malnourished with pale skin, cervical @entity3298 , frequent fever and generalized @entity158 . The intra-oral clinical examination found @entity7868 , multiple @entity1066 , necrotizing @entity3136 and @entity4034 located in the maxillary and mandibular regions. The necrotizing @entity3136 and @entity4034 were treated locally with atraumatic removal of the necrotized tissues. The @entity1 received a daily preventive protocol consisting of oral hygiene care, including twice daily brushing, and mouthrinses with a solution of @entity1216 . She was also treated with systemic @entity868 and @entity115 for 21 days. RESULTS: During the course of management the @entity1 's oral condition improved with some re-epithelialization being noted. However, severe alveolar @entity79 remained evident. Thirty-two months after presentation of the initial symptoms, the @entity1 died due to complications related to @entity1778 recurrence ( @entity548 , @entity295 and @entity649 ). CONCLUSIONS: Dental monitoring during @entity5 treatment is imperative in order to emphasize the importance of dental plaque control and the maintenance of a healthy periodontal condition throughout medical treatment.

title: Severe necrotizing @entity3136 and XXXX after chemotherapy for acute @entity1778 .

answer: @entity4034 :: (MESH:D010019,Disease) :: ['osteomyelitis']


abstract: AIM: @entity1 with motor disabilities are at increased risk of compromised bone health. This study evaluated prevalence and risk factors of low bone mass and @entity174 in these @entity1 . METHOD: This cross-sectional cohort study evaluated bone health in 59 @entity1 (38 males, 21 females; median age 10 y 11 mo) with @entity717 (Gross Motor Function Classification System levels II-V). Bone mineral density (BMD) in the lumbar spine was measured with dual-energy X-ray absorptiometry; BMD values were corrected for bone size (bone mineral apparent density [BMAD]) and skeletal maturity, and compared with normative data. Spinal radiographs were obtained to assess vertebral morphology. Blood biochemistry included @entity560 concentration and other parameters of @entity460 homeostasis. RESULTS: Ten @entity1 (17%) had sustained in total 14 peripheral @entity174 ; @entity174 predominated. @entity3814 were present in 25%. The median spinal BMAD z-score was -1.0 (range -5.0 to 2.0); it was -0.6 in those without @entity174 and -1.7 in those with @entity174 (p=0.004). @entity560 insufficiency was present in 59% of participants (serum @entity14257 <50 nmol/l) and @entity5200 in 27%. Low BMAD z-score and @entity5200 were independent predictors for @entity174 . INTERPRETATION: @entity1 with @entity717 are at high risk of @entity174 and @entity79 . Evaluation of bone health and prevention of @entity170 should be included in the follow-up.

title: Low bone mass in @entity1 with XXXX : prevalence and risk factors in 59 Finnish @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'lower-limb fractures', 'peripheral and vertebral fractures']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity3814 :: ('MESH:D050815', 'Disease') :: ['Compression fractures']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity14257 :: ('MESH:C104450', 'Chemical') :: ['25-hydroxyvitamin D']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['motor disability']

entities_list: @entity5200 :: ('MESH:D053565', 'Disease') :: ['hypercalciuria']

entities_list: @entity560 :: ('MESH:D014807', 'Chemical') :: ['vitamin D', 'Vitamin D']

answer: @entity717 :: (MESH:D009069,Disease) :: ['motor disability']


abstract: AIM: @entity1 with motor disabilities are at increased risk of compromised bone health. This study evaluated prevalence and risk factors of low bone mass and @entity174 in these @entity1 . METHOD: This cross-sectional cohort study evaluated bone health in 59 @entity1 (38 males, 21 females; median age 10 y 11 mo) with @entity717 (Gross Motor Function Classification System levels II-V). Bone mineral density (BMD) in the lumbar spine was measured with dual-energy X-ray absorptiometry; BMD values were corrected for bone size (bone mineral apparent density [BMAD]) and skeletal maturity, and compared with normative data. Spinal radiographs were obtained to assess vertebral morphology. Blood biochemistry included @entity560 concentration and other parameters of @entity460 homeostasis. RESULTS: Ten @entity1 (17%) had sustained in total 14 peripheral @entity174 ; @entity174 predominated. @entity3814 were present in 25%. The median spinal BMAD z-score was -1.0 (range -5.0 to 2.0); it was -0.6 in those without @entity174 and -1.7 in those with @entity174 (p=0.004). @entity560 insufficiency was present in 59% of participants (serum @entity14257 <50 nmol/l) and @entity5200 in 27%. Low BMAD z-score and @entity5200 were independent predictors for @entity174 . INTERPRETATION: @entity1 with @entity717 are at high risk of @entity174 and @entity79 . Evaluation of bone health and prevention of @entity170 should be included in the follow-up.

title: Low bone mass in XXXX with @entity717 : prevalence and risk factors in 59 Finnish @entity1 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIM: @entity1 with motor disabilities are at increased risk of compromised bone health. This study evaluated prevalence and risk factors of low bone mass and @entity174 in these @entity1 . METHOD: This cross-sectional cohort study evaluated bone health in 59 @entity1 (38 males, 21 females; median age 10 y 11 mo) with @entity717 (Gross Motor Function Classification System levels II-V). Bone mineral density (BMD) in the lumbar spine was measured with dual-energy X-ray absorptiometry; BMD values were corrected for bone size (bone mineral apparent density [BMAD]) and skeletal maturity, and compared with normative data. Spinal radiographs were obtained to assess vertebral morphology. Blood biochemistry included @entity560 concentration and other parameters of @entity460 homeostasis. RESULTS: Ten @entity1 (17%) had sustained in total 14 peripheral @entity174 ; @entity174 predominated. @entity3814 were present in 25%. The median spinal BMAD z-score was -1.0 (range -5.0 to 2.0); it was -0.6 in those without @entity174 and -1.7 in those with @entity174 (p=0.004). @entity560 insufficiency was present in 59% of participants (serum @entity14257 <50 nmol/l) and @entity5200 in 27%. Low BMAD z-score and @entity5200 were independent predictors for @entity174 . INTERPRETATION: @entity1 with @entity717 are at high risk of @entity174 and @entity79 . Evaluation of bone health and prevention of @entity170 should be included in the follow-up.

title: Low bone mass in @entity1 with @entity717 : prevalence and risk factors in 59 Finnish XXXX .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: AIM: To undertake a proof-of-concept study to determine whether a removable offloading device (the Ransart boot) for the management of @entity4760 ( @entity4760 ) was as effective as reports of non-removable devices. RESEARCH DESIGN AND METHODS: This observational study used the Ransart boot for @entity1 with @entity4760 , in seven specialist centres. If a @entity1 had two or more @entity1066 , one was selected as the index @entity1066 . Ulcers were classified by the University of Texas (UT) system. RESULTS: There were 135 @entity1 (mean age 60.3 +/- 11.4 years); 96 (71.1%) male. Median @entity1066 duration at presentation was 90 [interquartile range (IQR) 30-1825] days. Seven were lost to follow-up, seven developed other major illnesses and four died; outcomes were documented in the remaining 117. Eighty-two (70.1% of 117) healed, after a median (IQR) 60 (43-99) days, while 22 (18.8%) @entity1066 were resolved by amputation (one major). The remaining 13 (11.1%) @entity1 were judged non-compliant. There was a close correlation between @entity1066 classification at baseline and both time to healing (P < 0.001 chi(2)-test) and amputation (P < 0.001; Spearman's rank correlation coefficient). There was a positive correlation between @entity1066 duration at presentation and time to healing (P < 0.02), UT class (P < 0.01), glycated haemoglobin (P < 0.02) and amputation (P < 0.04). CONCLUSIONS: Time to healing and incidence of amputation were comparable with those previously reported for non-removable devices. Given that a removable device is much more acceptable to the @entity1 , the effectiveness, cost and acceptability of the removable devices, such as the Ransart boot, need to be compared with a non-removable device in a randomized trial. Diabet. Med. 26, 778-782 (2009).

title: A proof-of-concept study of the effectiveness of a removable device for offloading in XXXX with neuropathic ulceration of the foot: the Ransart boot.

entities_list: @entity4760 :: ('MESH:D017719', 'Disease') :: ['diabetic foot ulcers', 'DFU']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Acute @entity1580 frequently causes life-threatening organ @entity63 . The optimal therapy for acute type-B @entity1580 is still controversial. Early surgery for acute dissections with organ malperfusion is known to carry a high morbidity and mortality. Endovascular treatment, such as stent placement for branch stenosis, percutaneous balloon fenestration for compression of the true channel and aortic stent placement to support collapsed true channel, is becoming an alternative form of treatment. However, it is not clear whether endovascular intervention alone is effective in the long term. We herein report a case of emergency percutaneous endovascular stenting with intentional surgical delay in a @entity1 who had visceral and lower extremity malperfusion due to acute type-B dissection. A 10x57 mm bare metal stent was inserted into the obliterated true channel of the thoracoabdominal aorta 3 h after onset of symptoms. It immediately relieved the abdominal and lower limb @entity63 symptoms. The advantage of small-sized stent placement is its easiness and being gentle to fragile intima. The small-sized stent placement for @entity1 with @entity697 with visceral organ @entity63 may be a promising 'bridging therapy' before they undergo traditional central repair.

title: Endovascular stent placement for acute type-B XXXX with malperfusion--an intentional surgical delay and a possible 'bridging therapy'.

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute aortic dissection']

entities_list: @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic']

answer: @entity1580 :: (MESH:C562834,Disease) :: ['aortic dissection']


abstract: Double-particle @entity400 ( @entity400 ) was performed for the detection of an intact heterodimeric form of @entity1 chorionic gonadotropin (intact hCG) composed in Profasi hCG (P-hCG). This technique relied on two mixed types of @entity1 O RBC, which were individually coated with two distinct monoclonal antibodies that recognized alpha or beta subunit of hCG, i.e. @entity6599 and BEL-5, respectively. The positive hemagglutination result was achieved by this technique. However, in the BEL-5 coated single-particle control system, positive results for both P-hCG and beta subunit hCG solution were realized. The occurrence of beta-multimer hCG was a causative molecule revealed by the hemagglutination inhibition technique. Thereby, the novel method called "combined immunoprecipitation and agglutination" was developed to overcome this problem. The free beta subunit together with the betamultimer hCG were eliminated from other forms presented in P-hCG after using the @entity6599 coated particles. The precipitated particles, which captured the heterodimer hCG molecule, reacted further with soluble BEL-5 to subsequently form a trellis. A positive result was obtained only with P-hCG, but not with beta subunit hCG or hLH. This study is inferable as a model for the detection of heterodimeric molecule by an elementary method.

title: Combined immunoprecipitation and agglutination for the detection of the heterodimeric molecule: XXXX chorionic gonadotropin as a study model.

entities_list: @entity400 :: ('MESH:D014202', 'Disease') :: ['RPHA', 'reversed passive hemagglutination']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Abstract The distribution of bacterial populations and activity were determined at two Ocean Drilling Program sites (1109 and 1115) in the Woodlark extensional Basin, near Papua New Guinea, Pacific Ocean. These relatively deep water (1 150-2 211 m), low organic @entity505 ( approximately 0.4%), low organic matter sedimentation sites, with average thermal gradients ( approximately 30 degrees C/km) are representative of large areas of ocean sediments. At a third site, 1118, with a higher thermal gradient (63 degrees C/km), only bacterial distributions and pore water @entity598 (bioavailable) concentrations were determined. Active bacterial populations were present to all depths at Sites 1109 and 1115, maximum depth 801 mbsf (metres below seafloor), and this represents the deepest and oldest marine sediments ( approximately 15 Ma) in which the presence of bacteria has been demonstrated using a combination of different approaches (direct microscopic and viable counts, radiotracer turnover and geochemical analysis). In addition, direct counts and geochemical data at Site 1118 provide strong evidence for significant bacterial populations to at least 842 mbsf (3.2x10(5)/cm(3)). Similar to previously studied subseafloor sediments, maximum bacterial populations and activity occurred in the upper approximately 20 m, with much lower rates (up to 10 000 times) in deeper layers. However, a depth integration of data demonstrated that the majority of bacterial cells and activity ( @entity597 reduction, methanogenesis, @entity1014 incorporation into DNA and @entity598 oxidation) occurred in the subsurface, below 20 m. For @entity597 reduction this was dependent on the depth of @entity597 penetration. @entity598 was an important substrate for methanogenesis. Despite being degraded, @entity598 concentrations in subsurface layers remained relatively constant (<10 @entity1874 ) and therefore, there must also have been deep @entity598 formation, which is consistent with the presence of acetogenic bacteria. These results extend the significance of deep @entity598 formation for the maintenance of subsurface bacterial populations to sediments representative of large areas of the ocean.

title: Geomicrobiology of deep, low organic XXXX sediments in the Woodlark Basin, Pacific Ocean.

entities_list: @entity598 :: ('CHEBI:47622', 'Chemical') :: ['Acetate', 'acetate']

entities_list: @entity1014 :: ('MESH:D013936', 'Chemical') :: ['thymidine']

entities_list: @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['carbon']


abstract: Kinetic analyses of bacterial growth, @entity1735 consumption, and metabolite production of 18 @entity38269 strains grown on @entity948 , @entity11276 , or inulin were performed. A principal component analysis of the data sets, expanded with the results of a genetic screen concerning the presence of a beta-fructofuranosidase gene previously encountered in @entity38269 (T), revealed the existence of four clusters among the bifidobacteria tested. Strains belonging to a first cluster could not degrade @entity11276 or inulin. Strains in a second cluster could degrade @entity11276 , displaying a preferential breakdown mechanism, but did not grow on inulin. @entity948 consumption was faster than @entity11276 degradation. A third cluster was composed of strains that degraded all @entity11276 fractions simultaneously and could partially break down inulin. @entity11276 degradation was substantially faster than @entity948 consumption. A fourth, smaller cluster consisted of strains that shared high @entity948 consumption and @entity11276 degradation rates and were able to perform partial breakdown of inulin. For all strains, a metabolic shift toward more @entity598 , @entity5189 , and @entity1068 production, at the expense of @entity880 production, was observed during growth on less readily fermentable energy sources. No correlation between breakdown patterns and the presence of the beta-fructofuranosidase gene could be detected. These variations indicate niche-specific adaptation of bifidobacteria and could have in vivo implications on the strain specificity of the stimulatory effect of inulin-type fructans on bifidobacteria.

title: In vitro kinetic analysis of fermentation of prebiotic inulin-type fructans by XXXX species reveals four different phenotypes.

entities_list: @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose', 'Fructose']

entities_list: @entity598 :: ('CHEBI:47622', 'Chemical') :: ['acetate']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity11276 :: ('MESH:C120489', 'Chemical') :: ['oligofructose', 'Oligofructose']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity38269 :: ('555970', 'Species') :: ['Bifidobacterium', 'Bifidobacterium animalis subsp. lactis DSM 10140']

answer: @entity38269 :: (555970,Species) :: ['Bifidobacterium']


abstract: RATIONALE: It is commonly stated that mortality from @entity649 ( @entity649 ) and @entity647 ( @entity647 ) is decreasing. OBJECTIVES: To systematically review the literature assessing @entity649 mortality over time and to determine @entity1 - and study-level factors independently associated with mortality. METHODS: We searched multiple databases (MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL) for prospective observational studies or @entity23 ( @entity23 ) published during the period 1984 to 2006 that enrolled 50 or more @entity1 with @entity647 / @entity649 and reported mortality. We pooled mortality estimates using random-effects meta-analysis and examined mortality trends before and after 1994 (when a consensus definition of @entity647 / @entity649 was published) and factors associated with mortality using meta-regression models. MEASUREMENTS AND MAIN RESULTS: Of 4,966 studies, 89 met inclusion criteria (53 observational, 36 @entity23 ). There was a total of 18,900 @entity1 (mean age 51.6 years; 39% female). Overall pooled weighted mortality was 44.3% (95% confidence interval [CI], 41.8-46.9). Mortality decreased with time in observational studies conducted before 1994; no temporal associations with mortality were demonstrated in @entity23 (any time) or observational studies (after 1994). Pooled mortality from 1994 to 2006 was 44.0% (95% CI, 40.1-47.5) for observational studies, and 36.2% (95% CI, 32.1-40.5) for @entity23 . Meta-regression identified study type (observational versus RCT, odds ratio, 1.36; 95% CI, 1.08-1.73) and @entity1 age (odds ratio per additional 10 yr, 1.27; 95% CI, 1.07-1.50) as the only factors associated with mortality. CONCLUSIONS: A decrease in @entity649 mortality was only seen in observational studies from 1984 to 1993. Mortality did not decrease between 1994 (when a consensus definition was published) and 2006, and is lower in @entity23 than observational studies.

title: Has mortality from XXXX decreased over time?: A systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['ARDS', 'acute respiratory distress syndrome']

entities_list: @entity23 :: ('MESH:D007174', 'Disease') :: ['randomized controlled trials', 'RCTs']

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury', 'ALI']

answer: @entity649 :: (MESH:D012128,Disease) :: ['acute respiratory distress syndrome']


abstract: PURPOSE: To determine the feasibility and report clinical outcomes of @entity2045 computed tomographic (CT) angiography with 64-section multidetector CT technology in the evaluation of @entity1 sustaining penetrating @entity130 . MATERIALS AND METHODS: This HIPAA-compliant retrospective study was approved by the institutional review board and consent was waived. All adult @entity130 @entity1 who sustained penetrating @entity130 to the @entity2045 and who underwent CT angiography based on the recommendation of the attending @entity130 surgeon after the initial clinical examination were included. All studies were acquired with 64-section CT technology between April 2005 and September 2007 at our level I @entity130 center. Two radiologists in consensus retrospectively reviewed all the CT angiograms for evidence of @entity1317 . Attenuation was measured with regions of interest placed within the arterial lumen of multiple segments of the @entity2045 arteries. Hospital course and disposition were determined by reviewing the @entity1 ' medical records, with a mean follow-up of 33 days. RESULTS: This study included 59 @entity1 (54 @entity1 , five @entity1 ; mean age, 27 years). Nineteen (32%) @entity1 had the following @entity1317 at CT angiography: @entity432 (n = 7), arterial extravasation (n = 6), isolated @entity2849 formation (n = 2), isolated focal @entity850 (n = 2), occlusion and @entity2849 formation (n = 1), and focal @entity850 and @entity2849 formation (n = 1). Of these 19 @entity1 , seven underwent surgical treatment. Evaluation of the technical quality of the @entity2045 angiograms demonstrated mean attenuation values of 244 HU. In 48 (81%) of 59 @entity1 , mean attenuation values were higher than 200 HU, with four (7%) @entity1 having mean attenuation values lower than 150 HU. CONCLUSION: Upper extremity CT angiograms obtained with 64-section CT demonstrated adequate technical quality in the majority of @entity1 and performed well clinically in @entity1 with penetrating @entity130 .

title: Upper extremity CT angiography in penetrating XXXX : use of 64-section multidetector CT.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['upper extremity']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['arterial occlusion']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['arterial injury', 'arterial injuries']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: INTRODUCTION AND OBJECTIVES: Both 8-mm-tip and irrigated-tip catheters improve outcomes in typical @entity956 . However, it is not yet known which is preferable. The objective was to compare the effectiveness of 8-mm-tip (Group 1) and open irrigated-tip (Group 2) catheters in the first ablation attempt. METHODS: A prospective randomized trial with a long-term follow-up was performed in @entity1 with documented typical @entity956 . For both types of catheter, the power was initially set to 50 W. The primary endpoint was ablation of the cavotricuspid isthmus in a procedure lasting, at most, 600 s. RESULTS: Group 1 contained 65 @entity1 and Group 2 contained 66, with no significant intergroup difference in baseline characteristics. Their mean age was 63+/-12 years, 80% were @entity1 , and 65% had structural @entity299 . The primary endpoint was achieved in 48 @entity1 (73.8%) in Group 1 and 49 (74.2%) in Group 2 (P=NS). In the remaining @entity1 , the procedure was continued at the physician's discretion and ablation was finally achieved in all cases. In the intention-to-treat analysis, there was no significant difference between the groups in the number of applications of the ablation device or in the duration of the ablation procedure, radioscopy or the total procedure. By 16+/-5 months of follow-up (>1 year in 98%), 8 (6.3%) @entity1 had experienced recurrence and 95 (74.2%) were free from any @entity943 . There was no differences between the groups. CONCLUSIONS: No difference was found between the effectiveness of 8-mm-tip and open irrigated-tip catheters in the first attempt at ablation of typical @entity956 .

title: Comparison of 8-mm-tip and irrigated-tip catheters in the ablation of isthmus-dependent XXXX : a prospective randomized trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity956 :: ('MESH:D001282', 'Disease') :: ['atrial flutter ablation', 'atrial flutter']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

answer: @entity956 :: (MESH:D001282,Disease) :: ['atrial flutter']


abstract: In our study, we examined socioeconomic, treatment-related, and psychologic experiences of parents during the @entity981 treatment of their @entity1 in an academic hospital in Indonesia. @entity1 were treated with the WK-ALL-2000 protocol and received donated chemotherapy. From November 2004 to April 2006, 51 parents were interviewed by psychologists using semi-structured questionnaires. The family income had decreased (69%) since the start of treatment. Parents lost their jobs (29% of fathers and 8% of mothers), most of whom stated that this loss of employment was caused by the @entity1778 of their @entity1 (87% of fathers and 100% of mothers). Treatment costs resulted in financial difficulties (78%), debts (65%), and forced parents either to postpone or withdraw from parts of treatment (18%). Parents mentioned needing more information (86%) from and contact (77%) with doctors. The parent organization did not pay any visits (69%) during hospitalization, nor did they give information (59%) or emotional support (55%). We have concluded that the socioeconomic impact of @entity1778 treatment was profound. Communication between parents and doctors requires improving. The role of the parent organization was insignificant and must be ameliorated.

title: Parental experiences of XXXX treatment in indonesia.

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'children', 'Children']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukemia']

answer: @entity1778 :: (MESH:D007938,Disease) :: ['childhood leukemia']


abstract: Severe reactions in exercise-induced @entity565 (EIA) seem to be underestimated in the published literature. We report two cases of near-miss death from EIA that occurred after a short run. We review 364 exercise tests that were performed between September 1987 and October 1988 by a standardised protocol on a treadmill, on @entity1 with possible EIA. A positive test, defined by a fall of FEV1 of at least 20% was found in 173 @entity1 . From 21 @entity1 with a fall of greater than 50%, 4 presented severe signs of: Cyanosis. Intense @entity1353 with impediment of speech. General malaise with @entity101 . These 4 @entity1 were not greatly different from @entity1 of the 50% fall group when compared for FEV1 before the test and for heart-rate during the test. They differed in the duration of the @entity565 , which was more protracted, despite the use of @entity2263 agonists. The onset of severe reactions is 2.3% of positive tests and seems to be unpredictable.

title: [Severe forms of effort-induced XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity565 :: ('MESH:D001249', 'Disease') :: ['asthma attack', 'asthma']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: BACKGROUND AND AIM: To describe @entity14 ( @entity14 ) mortality trends during 1985-2004 and to estimate @entity14 mortality projections for the period 2005-2019 in Spain. MATERIAL AND METHODS: A Bayesian age-period-cohort analysis has been carried out to investigate the effect of the age, period, and birth cohort on @entity14 mortality in Spain. Mortality projections until 2019 were based on the age-period-cohort model. RESULTS: During 1985-1994, @entity14 mortality increased in both sexes (3.9% yearly in @entity1 and 1.5% in @entity1 ). After 1995, @entity14 mortality increased in @entity1 (1.6%) and leveled off in @entity1 (-0.6%). @entity694 mortality increased for the whole period in @entity1 , this increase being lower in the second decade (1985-1994: 5.0%; 1995-2004: 1.8%). In @entity1 , @entity694 mortality increased in the first decade (2.8%) and leveled off during the second decade (-0.1%). @entity5 mortality increased in @entity1 (1.2%) and decreased in @entity1 (-1.1%) during the whole study period. Projections showed an increase in the number of @entity14 in @entity1 older than 60 years and a level off in @entity1 . CONCLUSION: Although mass screening for @entity14 in Spain has not been available, the favorable recent changes in @entity14 mortality trends observed after 1995 could be related to progress in diagnosis and treatment. The projected number of @entity204 could be used as reference scenario for assessing future impact of new treatments as well as the potential impact of future population-based screening when introduced.

title: XXXX mortality in Spain: trends and projections for 1985-2019.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Rectal cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'CRC deaths', 'colorectal cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['Colon cancer', 'colon cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal cancer']


abstract: Inhibition of osteoblast-mediated mineralization is one of the major catabolic effects of @entity10173 ( @entity10173 ) on bone. Previously, we showed that @entity10173 induces matrix @entity16699 ( @entity9984 ) protein ( @entity45818 ) expression and established that this induction is critical for @entity10173 -mediated inhibition of osteoblast mineralization. In the present study, we focus on the mechanism through which @entity10173 regulates @entity45818 expression in osteoblastic @entity19 cells. Following transient transfection of these cells with a -748 bp @entity19 @entity45818 promoter-luciferase construct (pMGP-luc), @entity10173 (10 (-7) M) induced promoter activity in a time-dependent manner with a maximal four- to six fold induction seen 6 h after @entity10173 treatment. Both @entity9501 (PKA inhibitor) and @entity5732 ( @entity13438 inhibitor), suppressed @entity10173 induction of @entity45818 promoter activity as well as the @entity45818 mRNA level. In addition, @entity1928 (PKA activator) stimulated @entity45818 promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of @entity45818 by @entity10173 . Co-transfection of @entity19 cells with pMGP-luc and @entity13438 (SP), a plasmid encoding the constitutively active form of @entity13438 , led to a dose-dependent increase in @entity45818 promoter activity. Both @entity45818 promoter activity and @entity45818 mRNA level were not affected by the protein kinase C (PKC) inhibitor, @entity11009 . However, @entity1359 ( @entity4515 ), a selective PKC activator induced @entity45818 mRNA expression through activation of @entity13436 ( @entity13436 ). Taken together, these results indicate that @entity10173 regulates @entity45818 via both PKA- and @entity13436 -dependent pathways.

title: Regulation of matrix Gla protein by XXXX in @entity19 osteoblast-like cells involves protein kinase A and @entity13436 pathways.

entities_list: @entity1359 :: ('CHEBI:37537', 'Chemical') :: ['phorbol 12-myristate 13-acetate']

entities_list: @entity16699 :: ('MESH:D015055', 'Chemical') :: ['gamma-carboxyglutamic acid']

entities_list: @entity13436 :: ('26413(Tax:10090)', 'Gene') :: ['ERK', 'extracellular signal-regulated kinase']

entities_list: @entity1928 :: ('MESH:D005576', 'Chemical') :: ['forskolin']

answer: @entity10173 :: (19226(Tax:10090),Gene) :: ['parathyroid hormone']


abstract: Inhibition of osteoblast-mediated mineralization is one of the major catabolic effects of @entity10173 ( @entity10173 ) on bone. Previously, we showed that @entity10173 induces matrix @entity16699 ( @entity9984 ) protein ( @entity45818 ) expression and established that this induction is critical for @entity10173 -mediated inhibition of osteoblast mineralization. In the present study, we focus on the mechanism through which @entity10173 regulates @entity45818 expression in osteoblastic @entity19 cells. Following transient transfection of these cells with a -748 bp @entity19 @entity45818 promoter-luciferase construct (pMGP-luc), @entity10173 (10 (-7) M) induced promoter activity in a time-dependent manner with a maximal four- to six fold induction seen 6 h after @entity10173 treatment. Both @entity9501 (PKA inhibitor) and @entity5732 ( @entity13438 inhibitor), suppressed @entity10173 induction of @entity45818 promoter activity as well as the @entity45818 mRNA level. In addition, @entity1928 (PKA activator) stimulated @entity45818 promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of @entity45818 by @entity10173 . Co-transfection of @entity19 cells with pMGP-luc and @entity13438 (SP), a plasmid encoding the constitutively active form of @entity13438 , led to a dose-dependent increase in @entity45818 promoter activity. Both @entity45818 promoter activity and @entity45818 mRNA level were not affected by the protein kinase C (PKC) inhibitor, @entity11009 . However, @entity1359 ( @entity4515 ), a selective PKC activator induced @entity45818 mRNA expression through activation of @entity13436 ( @entity13436 ). Taken together, these results indicate that @entity10173 regulates @entity45818 via both PKA- and @entity13436 -dependent pathways.

title: Regulation of matrix Gla protein by @entity10173 in @entity19 osteoblast-like cells involves protein kinase A and XXXX pathways.

answer: @entity13436 :: (26413(Tax:10090),Gene) :: ['extracellular signal-regulated kinase']


abstract: Inhibition of osteoblast-mediated mineralization is one of the major catabolic effects of @entity10173 ( @entity10173 ) on bone. Previously, we showed that @entity10173 induces matrix @entity16699 ( @entity9984 ) protein ( @entity45818 ) expression and established that this induction is critical for @entity10173 -mediated inhibition of osteoblast mineralization. In the present study, we focus on the mechanism through which @entity10173 regulates @entity45818 expression in osteoblastic @entity19 cells. Following transient transfection of these cells with a -748 bp @entity19 @entity45818 promoter-luciferase construct (pMGP-luc), @entity10173 (10 (-7) M) induced promoter activity in a time-dependent manner with a maximal four- to six fold induction seen 6 h after @entity10173 treatment. Both @entity9501 (PKA inhibitor) and @entity5732 ( @entity13438 inhibitor), suppressed @entity10173 induction of @entity45818 promoter activity as well as the @entity45818 mRNA level. In addition, @entity1928 (PKA activator) stimulated @entity45818 promoter activity and mRNA levels confirming that PKA is one of the signaling molecules required for regulation of @entity45818 by @entity10173 . Co-transfection of @entity19 cells with pMGP-luc and @entity13438 (SP), a plasmid encoding the constitutively active form of @entity13438 , led to a dose-dependent increase in @entity45818 promoter activity. Both @entity45818 promoter activity and @entity45818 mRNA level were not affected by the protein kinase C (PKC) inhibitor, @entity11009 . However, @entity1359 ( @entity4515 ), a selective PKC activator induced @entity45818 mRNA expression through activation of @entity13436 ( @entity13436 ). Taken together, these results indicate that @entity10173 regulates @entity45818 via both PKA- and @entity13436 -dependent pathways.

title: Regulation of matrix Gla protein by @entity10173 in XXXX osteoblast-like cells involves protein kinase A and @entity13436 pathways.

answer: @entity19 :: (10090,Species) :: ['MC3T3-E1']


abstract: One hundred and twenty-eight @entity1 undergoing assessment for genetic risk of @entity5344 completed questionnaires at entry into the assessment process and following risk provision. The key variable of interest was the level of intrusive worries at each time, and factors associated with the level of intrusive worries following risk provision. Based on the CARA model (Renner, Pers Soc Psychol Bull 30:384-396, 2004), it was expected that an unexpected risk assessment (whether good or bad) would result in high levels of intrusive thoughts. Other potential moderators of worry included @entity663 , level of threat experienced (low control, high perceived risk), the use of differing coping efforts, and the available social support. Of note was that while levels of intrusive thoughts fell in all risk groups following risk provision, unexpectedly only @entity1 found to be at population risk reported an increase of active attempts to distract from intrusive worries at this time. The CARA model was not supported. However, intrusion scores were independently associated with higher levels of @entity663 , a lack of confidant support, and a confrontive coping response. Active avoidance scores were uniquely associated with being assigned as population risk, @entity663 , lack of confidant and affective support, and the use of avoidant coping. Together, these variables accounted for 33% of the variance in intrusion scores and 31% of the variance in avoidance scores. The implications of these findings is discussed.

title: Factors associated with intrusive cancer-related worries in XXXX undergoing cancer genetic risk assessment.

entities_list: @entity5344 :: ('MESH:D061325', 'Disease') :: ['breast/ovarian cancer']

entities_list: @entity663 :: ('MESH:C564323', 'Disease') :: ['neuroticism']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND: A rare and peculiar @entity8 has begun to be recognized in Japan. The Japanese Society of Nephrology has established a research working group and has collected cases from all over Japan in an attempt to understand the complete spectrum of this @entity8 . METHOD: The diagnostic criterion, which was needed to collect the cases, was proposed as a @entity8 showing microspheres or microtubular structures or both associated with podocytic infolding into the glomerular basement membrane (GBM) on electron microscopy. The lesion shows a non-argentaffin hole in the GBM with periodic acid @entity1332 staining and is similar to @entity631 . RESULTS: Twenty-five cases were collected from 17 institutions. @entity1 were 20-69 years old (19 @entity1 , 6 @entity1 ). Seventeen @entity1 also had collagen diseases such as @entity1988 and @entity244 . All @entity1 had @entity644 . @entity644 showed a remission in 15 of 23 @entity1 within 12 months, but @entity644 remained higher than 1.0 g/day in five @entity1 despite different types of therapy. Podocytic infolding including microspheres showed either positive or negative staining for immunoglobulins. Cluster formation of microspheres was found in 4 of 17 @entity1 with @entity1413 , and in five out eight @entity1 without @entity1413 . Electron-dense deposits in the GBM were also found in 6 of 17 @entity1 with @entity1413 but were not found in eight @entity1 without @entity1413 . CONCLUSION: Some @entity1 might have a subtype of @entity1988 , class V, or @entity631 . However, we propose a new disease entity, podocytic infolding @entity8 , as a common basis of all 25 @entity1 , because we suspect that microspheres or microtubular structures or both can be derived from podocytic infolding.

title: Proposal of podocytic infolding XXXX as a new disease entity: a review of 25 cases from nationwide research in Japan.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria', 'Proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerulopathy']

entities_list: @entity1988 :: ('MESH:D008181', 'Disease') :: ['lupus nephritis']

entities_list: @entity244 :: ('MESH:D014899', 'Disease') :: ["Sj  gren's syndrome"]

entities_list: @entity1332 :: ('MESH:D008709', 'Chemical') :: ['methenamine silver']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['membranous glomerulonephritis']

entities_list: @entity1413 :: ('MESH:D003095', 'Disease') :: ['collagen disease']

answer: @entity8 :: (MESH:D007674,Disease) :: ['glomerulopathy']


abstract: PURPOSE: To retrospectively assess the local control and intermediate- and long-term survival of @entity1 with liver metastases from @entity0 who have undergone percutaneous ultrasonography (US)-guided radiofrequency (RF) ablation. MATERIALS AND METHODS: This study was approved by the hospital ethics committee, and all @entity1 provided written informed consent. RF ablation was used to treat 87 @entity0 (mean diameter, 2.5 cm) in 52 female @entity1 (median age, 55 years). Inclusion criteria were as follows: fewer than @entity5 , maximum @entity5 diameter of 5 cm or smaller, and disease either confined to the liver or stable with medical therapy. Forty-five (90%) of 50 @entity1 had previously undergone chemotherapy, hormonal therapy, or both, and had no response or an incomplete response to the treatment. Contrast material-enhanced computed tomography and US were performed to evaluate complications and technical success and to assess for local @entity5 progression during follow-up. The Kaplan-Meier method was used to assess survival, and results were compared between groups with a log-rank test. Cox regression analysis was used to assess independent prognostic factors that affected survival. RESULTS: Complete @entity5 @entity39 was achieved in 97% of @entity5 . Two (4%) minor complications occurred. Median time to follow-up from diagnosis of liver @entity3 and from RF ablation was 37.2 and 19.1 months, respectively. Local @entity5 progression occurred in 25% of @entity1 . New intrahepatic metastases developed in 53% of @entity1 . From the time of first RF ablation, overall median survival time and 5-year survival rate were 29.9 months and 27%, respectively. From the time the first liver @entity3 was diagnosed, overall median survival time was 42 months, and the 5-year survival rate was 32%. @entity1 with @entity5 2.5 cm in diameter or larger had a worse prognosis (hazard ratio, 2.1) than did @entity1 with @entity5 smaller than 2.5 cm in diameter. CONCLUSION: Survival rates in selected @entity1 with @entity0 treated with RF ablation are comparable to those reported in the literature that were achieved with surgery or laser ablation.

title: XXXX : US-guided percutaneous radiofrequency ablation--intermediate and long-term survival rates.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer liver metastases', 'breast cancer']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'five tumors', 'tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast cancer liver metastases']


abstract: PURPOSE: To investigate the feasibility of magnetically labeling stem cells with superparamagnetic @entity1933 (SPIO) by means of microbubble-enhanced ultrasonographic (US) exposure (MUE) and to study the effects of this approach--without secondary transfection agents--on the viability, proliferation activity, and differentiation capability of @entity72742 -labeled stem cells. MATERIALS AND METHODS: Institutional review board approval was obtained for this study. @entity1 mesenchymal stem cells (MSCs) ([1 to 2] x 10(6)/mL) were studied in four experiment groups: sham exposure to US with microbubbles and SPIO (group A), exposure to US with SPIO but without microbubbles (group B), exposure to US with microbubbles and SPIO (group C), and sham exposure to US without SPIO or microbubbles (group D). Intracellular @entity68 uptake was analyzed qualitatively at light and electron microscopy. The viability and proliferation activity of MSCs were evaluated. The adipogenic and osteogenic differentiation capability of the labeled MSCs was also evaluated. Ninety-five percent confidence intervals were derived for assessment of differences in cell viability and proliferation activity between groups C and D. RESULTS: Light and electron microscopy revealed intracytoplasmic @entity68 uptake and nearly 100% cell labeling efficiency. The MUE-labeled MSCs had unaltered viability and uncompromised proliferation activity compared with the nonlabeled MSCs. Similar to the nonlabeled MSCs, the MUE-labeled MSCs differentiated into adipogenic and osteogenic lineages. CONCLUSION: Initial study results show that stem cells can be effectively labeled with SPIO by using MUE without secondary transfection agents and thus that MUE labeling is an appealing alternative cell-labeling approach that warrants investigation for intracellular magnetic labeling of stem cells. SUPPLEMENTAL MATERIAL: http://radiology.rsna.org/lookup/suppl/doi:10.1148/radiol.2531081974/-/DC1.

title: In vitro labeling of mesenchymal stem cells with superparamagnetic XXXX by means of microbubble-enhanced US exposure: initial experience.

entities_list: @entity1933 :: ('MESH:C000499', 'Chemical') :: ['iron oxide']

answer: @entity1933 :: (MESH:C000499,Chemical) :: ['iron oxide']


abstract: The aim of this study was to review our experience with a treatment regimen that combined conventionally fractionated radiation therapy (70 Gy over 7 weeks) with chemotherapy ( @entity900 and @entity1487 ), given concurrently in the last 2 weeks of radiation therapy in @entity1 with previously untreated advanced @entity135 region.Twenty-eight @entity1 , all but two having UICC stage IV disease, were treated at the Peter MacCallum Cancer Institute between November 1995 and April 1998. Planned chemotherapy consisted initially of continuous infusion at 10 mg/m(2) per day of @entity900 and 400 mg/m(2) per day of @entity1487 on days 1-5 of weeks 6 and 7 of a conventionally fractionated course of radiotherapy. After the first 14 @entity1 , the dose of @entity1487 was reduced to 360 mg/m(2) per day because of acute @entity137 .36.8 months), with an estimated 50% surviving at 2 years (CI, 29-71%). Sixteen @entity1 (57%) developed confluent @entity33 and 11 (39%) developed @entity33 . The median duration of @entity33 for these 27 @entity1 was 1.5 months. Seventeen @entity1 (61%) required nutritional support for a median duration of 1.4 months. Fourteen @entity1 (50%) had grade three skin reactions, and 12 (43%) had one or more other significant (Grade 3) @entity137 , predominantly infective. Grade 3 late @entity137 has been observed in three @entity1 to date (three @entity2133 , including one with severe @entity308 ), and one @entity1 had chronic ulceration of the oral tongue (grade 4). This chemoradiation regimen achieved an excellent complete response rate and good locoregional control at 2 years in @entity1 with a poor initial prognosis. Acute @entity137 was significant but manageable. The regimen offers an alternative to surgery and postoperative radiation therapy in locally advanced @entity135 .

title: Radiation with concurrent late chemotherapy intensification ('chemoboost') for locally advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['squamous cell cancer of the head and neck', 'head and neck cancer']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['xerostomia']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['patchy mucositis', 'mucositis']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck cancer']


abstract: AIM: To examine the parent-dependent barriers to @entity992 immunization in Israel. METHODS: Data were collected by questionnaire from parents of @entity1 aged 1 to 18 years who attended an outpatient paediatric centre in five cities in Israel from March to May 2003. RESULTS: A total of 1474 parents completed the questionnaire. A history of @entity1573 pox was reported in 850 @entity1 (57.8%), mostly (83%) between ages 1-6 years. Of the 624 @entity1 without a history of @entity1573 pox, 213 (34.1%) were immunized against @entity992 . Immunization rates were significantly lower in families with lower parental education and in @entity1 from cities with a lower socioeconomic ranking (p < 0.05). The main reasons for not being vaccinated (49%) were related to insufficient information about the vaccine itself and the vaccination process. These reasons were more common in families with lower parental education and from cities with lower socioeconomic ranking (p < 0.01). Other reasons included fear of adverse effects (12%) and waning immunity (6%), preference of @entity221 over immunization (12%), and financial limitations (5%). CONCLUSIONS: Promoting parental knowledge about the @entity992 vaccine appears to be a key factor in improving the immunization rate, especially in families of lower education, and from cities with low socioeconomic ranking.

title: Parent-dependent barriers to XXXX immunization in Israel: the importance of adequate information.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['natural illness']

entities_list: @entity992 :: ('MESH:D002644', 'Disease') :: ['varicella']

answer: @entity992 :: (MESH:D002644,Disease) :: ['varicella']


abstract: PURPOSE: To compare conventional fractionation with hypofractionation in @entity1 with a @entity463 multiforme. Endpoints of the analysis are overall survival and palliative effect. MATERIALS AND METHODS: From 1988 to 1998, 155 @entity1 with pathologically confirmed @entity463 multiforme were prospectively analysed. @entity1 without @entity7841 and @entity1 receiving an interstitial boost were excluded from this analysis. Three different radiation schemes were used in subsequent periods; 33x2, 8x5 and 4x7 Gy. In the last 5 years a scheme of 4x7 Gy conformal @entity7841 was given to poor prognosis @entity1 . The more favourable group received the conventionally fractionated scheme up to 66 Gy. RESULTS: Median survival was 7, 5.6 and 6.6 months for the 33x2, 8x5 and 4x7 Gy, respectively. In general, @entity1 in the hypofractionation group had far worse prognostic factors compared with @entity1 treated with the conventional scheme. The period of neurological improvement or stabilisation was similar between the 4x7 and 33x2 Gy group. CONCLUSION: An extreme hypofractionation scheme of 4x7 Gy conformal @entity7841 in poor prognostic @entity463 @entity1 is well tolerated, convenient for the @entity1 and provides equal palliation without negative effects on survival compared with conventional fractionation.

title: Hypofractionation in XXXX multiforme.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity7841 :: ('MESH:D012793', 'Disease') :: ['irradiation']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']

answer: @entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']


abstract: Within the International Classification of Functioning, Disability, and Health (ICF; WHO), participation in work is acknowledged as one of the major areas in life (D8). Difficulties that make it impossible for the @entity1 to optimally partake in work result in participation restriction. An increasing number of @entity1 with @entity393 are seeking help for @entity3675 . Various studies identified issues that should be addressed in the management of employees with @entity393 and emphasized the importance of a tailored vocational enablement program. This paper describes a recently developed vocational enablement protocol (VEP) addressing the specific needs of those with @entity393 in the workforce. It is characterized by an integrated approach (occupational physician, otolaryngologist, audiologist, social worker/psychologist, speech-language pathologist). The goal is to facilitate participation in, and retention of, work. The protocol is currently implemented in a few audiological centers in the Netherlands. This paper presents data collected at the audiological center of the VU University Medical Center, Amsterdam. Thus far, 86 @entity1 , aged 19 to 64 years (mean 48, SD 23), have completed the protocol. Experiences with the procedure are described, and recommendations for future practice and research are discussed.

title: XXXX , work, and vocational enablement.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'person', 'people']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity3675 :: ('MESH:D009784', 'Disease') :: ['occupational problems']

answer: @entity393 :: (MESH:D034381,Disease) :: ['Hearing impairment']


abstract: BACKGROUND: In vitro models are indispensable study objects in the fields of cell and molecular biology, with advantages such as accessibility, homogeneity of the cell population, reproducibility, and growth rate. The Caco-2 cell line, originating from a @entity694 , is a widely used in vitro model for small intestinal epithelium. @entity5 cells have an altered metabolism, making it difficult to infer their representativity for the tissue from which they are derived. This study was designed to compare the protein expression pattern of Caco-2 cells with the patterns of intestinal epithelial cells from @entity1 small and large intestine. HT-29 intestinal cells, Hep G2 liver cells and TE 671 muscle cells were included too, the latter two as negative controls. RESULTS: Two-dimensional gel electrophoresis was performed on each tissue and cell line protein sample. Principal component and cluster analysis revealed that global expression of intestinal epithelial scrapings differed from that of intestinal epithelial cell lines. Since all cultured cell lines clustered together, this finding was ascribed to an adaptation of cells to culture conditions and their @entity5 origin, and responsible proteins were identified by mass spectrometry. When investigating the profiles of Caco-2 cells and small intestinal cells in detail, a considerable overlap was observed. CONCLUSION: Numerous proteins showed a similar expression in Caco-2 cells, HT-29 cells, and both the intestinal scrapings, of which some appear to be characteristic to @entity1 intestinal epithelium in vivo. In addition, several biologically significant proteins are expressed at comparable levels in Caco-2 cells and small intestinal scrapings, indicating the usability of this in vitro model. Caco-2 cells, however, appear to over-express as well as under-express certain proteins, which needs to be considered by scientists using this cell line. Hence, care should be taken to prevent misinterpretation of in vitro obtained findings when translating them to the in vivo situation.

title: Comparative proteomic analysis of cell lines and scrapings of the XXXX intestinal epithelium.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon carcinoma']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: INTRODUCTION: Twenty per cent of the operated @entity1 suffering from cryptorchidisim show no palpable @entity1062 in the physical check-up. The use of a non-palpable @entity1062 in the initial stages is considered to be controversial when deciding between a laparascopic or an inguinal approach. Our aim is to compare the results obtained with these two approaches and evaluate which one of them would be the most relevant as an initial option. MATERIALS AND METHODS: We examined the @entity1 who have been subjected to surgical intervention for non-palpable @entity1062 in the last three years. We had a sample of 53 @entity1 . Bilateral non-palpable @entity1062 were disregarded. In the case of 35 @entity1 the initial approach was through the groins while in 18 of them the approach was laparascopic. Relevant data were recorded, such as the age of the @entity1 , right or left side, surgical findings, need for a laparascopic or groin approach and associated @entity547 . RESULTS: The average age of the @entity1 at the time of the surgical treatment was 3.7 years R (1-13 years). 42% of the @entity1062 were on the right side and 58% on the left. In an initial stage the inguinal approach was used with 35 @entity1 , 2 of these requiring laparascopic exploration due to a non-concluding check-up; it was concluded that they were 2 cases of @entity2357 . An initial laparoscopic approach was used with 18 @entity1 . Internal vessels in the canal were found which required an inguinal approach. In 12 @entity1 normal or @entity3202 @entity1062 were observed. Testicular descent was achieved through the groin in 10 of them while in the remaining 2 a combined approach was adopted. CONCLUSIONS: 80% of the @entity1 subjected to a first laparoscopic approach needed a groin approach later on. 11% of the @entity1 subjected to a first inguinal approach required laparascopic examination. In view of the results obtained, we conclude that inguinal exploration diminishes the need for second procedures.

title: [Non-palpable XXXX : laparoscopic or inguinal approach?].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1062 :: ('MESH:D013736', 'Disease') :: ['testes', 'testis']

answer: @entity1062 :: (MESH:D013736,Disease) :: ['testes']


abstract: OBJECTIVE: High blood pressure (BP) is a leading risk factor for @entity65 and mortality. Effective antihypertensive pharmacotherapy is available but recognition and proper management of @entity101 and BP goal achievement is still poor. Therefore, it was hypothesized that physicians' attitude towards high BP, as well as @entity1 ' perception and knowledge, may influence actual management of @entity101 . RESEARCH DESIGN AND METHODS: Telephone interviews were carried out with a random sample of 1259 primary care physicians in 17 countries worldwide from 12 December 2005 to 13 January 2006 using a central computer assisted telephone interview methodology (CATI). RESULTS: (1) Physicians believed that 62 +/- 21% of their @entity1 had their BP controlled. (2) They were mostly in line with guideline recommended BP goals and 96% were aware of the elevated cardiovascular risk of @entity101 , but 41% aimed to reduce BP to acceptable levels only. (3) Physicians indicated that in 41% of @entity1 monotherapy controls BP and 71% would escalate to combination therapy after monotherapy failure. (4) 54% regard @entity101 management as difficult. (5) Physicians estimated that between 60 and 70% of @entity1 know their BP goal but thought that there was still room for improvement of @entity101 management on the @entity1 side. CONCLUSION: Although many effective treatment options for arterial @entity101 exist, BP goal achievement worldwide is suboptimal, leaving @entity1 at an unnecessary cardiovascular risk. An increase in @entity1 ' awareness and compliance together with an increased adherence of physicians to current guidelines should help in reducing the long term cardiovascular consequences of @entity101 .

title: Clinical practice and recent recommendations in XXXX management--reporting a gap in a global survey of 1259 primary care physicians in 17 countries.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular morbidity']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: Atrial pacing and @entity3154 scintigraphy were performed in 72 @entity1 referred for evaluation of @entity662 . @entity453 ( @entity453 ) was present in 63 @entity1 , as documented by cardiac catheterization performed at the same time or within 2 months of atrial pacing. Nine @entity1 had no or insignificant (less than 50% stenosis) @entity453 . The sensitivity of pacing-induced @entity951 for @entity453 was 51%, and was 49% for ST @entity308 . Specificities were 89% and 78%, respectively. A reversible perfusion defect was seen in 54% of @entity1 with @entity453 (specificity 89%), and a fixed defect in 29% (specificity 100%). The sensitivity of an abnormal thallium-201 scan (one or more reversible or fixed defects) was 79% (p less than 0.05 compared to @entity308 ). Combined sensitivity of ST @entity308 and/or an abnormal thallium-201 scan was 87%. There were no significant changes in any of these sensitivities as the number of vessels with @entity453 increased. @entity3154 scintigraphy correctly identified 11 of 19 (58%) @entity1 with @entity66 as having @entity453 in only one vessel, but underestimated the extent of disease in all but a few @entity1 with multivessel disease. The sensitivity of perfusion imaging to identify lesions in specific vessels ranged from 27% (circumflex) to 57% (right coronary artery). Specificities were 100% for circumflex, 78% for anterior descending, and 83% for right coronary artery lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Atrial pacing and thallium-201 scintigraphy in @entity1 with XXXX : correlation with coronary anatomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'angina or ST depression']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['single-vessel disease']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['Coronary artery disease', 'CAD']

answer: @entity662 :: (MESH:D002637,Disease) :: ['chest pain']


abstract: Atrial pacing and @entity3154 scintigraphy were performed in 72 @entity1 referred for evaluation of @entity662 . @entity453 ( @entity453 ) was present in 63 @entity1 , as documented by cardiac catheterization performed at the same time or within 2 months of atrial pacing. Nine @entity1 had no or insignificant (less than 50% stenosis) @entity453 . The sensitivity of pacing-induced @entity951 for @entity453 was 51%, and was 49% for ST @entity308 . Specificities were 89% and 78%, respectively. A reversible perfusion defect was seen in 54% of @entity1 with @entity453 (specificity 89%), and a fixed defect in 29% (specificity 100%). The sensitivity of an abnormal thallium-201 scan (one or more reversible or fixed defects) was 79% (p less than 0.05 compared to @entity308 ). Combined sensitivity of ST @entity308 and/or an abnormal thallium-201 scan was 87%. There were no significant changes in any of these sensitivities as the number of vessels with @entity453 increased. @entity3154 scintigraphy correctly identified 11 of 19 (58%) @entity1 with @entity66 as having @entity453 in only one vessel, but underestimated the extent of disease in all but a few @entity1 with multivessel disease. The sensitivity of perfusion imaging to identify lesions in specific vessels ranged from 27% (circumflex) to 57% (right coronary artery). Specificities were 100% for circumflex, 78% for anterior descending, and 83% for right coronary artery lesions.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Atrial pacing and thallium-201 scintigraphy in XXXX with @entity662 : correlation with coronary anatomy.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Since 1981, a total of 729 ileal pouch-anal anastomoses have been performed at the Mayo Clinic-affiliated hospitals. Three hundred fifty-four were in @entity1 . Twenty of these @entity1 subsequently had at least one successful pregnancy and delivery. Eleven deliveries were vaginal with episiotomy, and nine were cesarean sections. No maternal @entity204 occurred. One @entity1 died of @entity8855 . The frequency of nocturnal stooling increased in the ileal pouch-anal @entity254 @entity1 during pregnancy (P less than .01), and the increase persisted for three months after delivery (P less than .05). In contrast, the frequency of daytime stools, the incidence of @entity322 , the consistency of the stool, and the development of perineal seepage or skin irritation were not greatly altered by pregnancy or delivery. Moreover, postpartum pouch function was not influenced by the type of delivery (vaginal vs. cesarean section). In conclusion, pregnancy and delivery are safe in @entity1 with the ileal pouch-anal @entity254 , but they lead to more frequent nocturnal stools. The type of delivery (vaginal vs. cesarean section) does not influence pouch functional outcome.

title: The effect of pregnancy and delivery on the ileal pouch-anal XXXX functions.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'child']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']

entities_list: @entity8855 :: ('MESH:D006819', 'Disease') :: ['hyaline membrane disease']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

answer: @entity254 :: (MESH:C563598,Disease) :: ['anastomosis']


abstract: BACKGROUND AND PURPOSE: The Oxfordshire @entity64 Project (OCSP) devised a simple classification for acute @entity64 based on clinical features only, which is of value in predicting prognosis. We investigated whether the pattern of @entity1504 is related to the clinical syndrome. METHODS: @entity1 with acute @entity385 were classified by a @entity64 physician as having total or partial anterior circulation @entity1188 ( @entity24603 or PACI, respectively), @entity1188 ( @entity1188 ), or posterior circulation @entity1188 (POCI). Color-coded power transcranial Doppler was done whenever possible. Intracranial arterial velocities were compared in the 4 subtypes of @entity385 after adjustment for age and time to transcranial Doppler. RESULTS: Middle cerebral artery velocity was abnormal ( @entity450 , reduced velocity, @entity432 , or focal @entity850 ) in 38 of 69 TACIs (55%), 50 of 171 PACIs (29%), and 20 of 236 LACIs or POCIs (8%) (P<0.001). Velocity in the A1 segment of the anterior cerebral artery was reversed in 12 of 69 TACIs (17%), 20 of 171 PACIs (12%), and 8 of 236 LACIs or POCIs (3%) (P<0.001). Basilar artery velocity was abnormal in 8 of 121 POCIs (7%) compared with 5 of 355 (1%) of the other subtypes (P=0.005). Vertebral artery velocity was abnormal (reduced velocity, @entity432 , @entity850 ) in 20 of 121 POCIs (17%) compared with 20 of 355 others (6%) (P=0.01). CONCLUSIONS: Intracranial @entity7244 were related to OCSP clinical subtype. Therefore, it is possible to stratify @entity1 according to OCSP classification in trials of new treatments in which treatment effectiveness may depend on the underlying pattern of arterial pathology and before any arterial imaging is available.

title: Relationship between pattern of intracranial @entity7244 on transcranial doppler and Oxfordshire XXXX Project clinical classification of @entity385 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['Community Stroke', 'stroke']

entities_list: @entity7244 :: ('MESH:D020765', 'Disease') :: ['arterial abnormalities']

entities_list: @entity450 :: ('MESH:D006940', 'Disease') :: ['hyperemia']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial vascular abnormalities']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'lacunar infarct', 'LACI']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusion']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Community Stroke']


abstract: BACKGROUND AND PURPOSE: The Oxfordshire @entity64 Project (OCSP) devised a simple classification for acute @entity64 based on clinical features only, which is of value in predicting prognosis. We investigated whether the pattern of @entity1504 is related to the clinical syndrome. METHODS: @entity1 with acute @entity385 were classified by a @entity64 physician as having total or partial anterior circulation @entity1188 ( @entity24603 or PACI, respectively), @entity1188 ( @entity1188 ), or posterior circulation @entity1188 (POCI). Color-coded power transcranial Doppler was done whenever possible. Intracranial arterial velocities were compared in the 4 subtypes of @entity385 after adjustment for age and time to transcranial Doppler. RESULTS: Middle cerebral artery velocity was abnormal ( @entity450 , reduced velocity, @entity432 , or focal @entity850 ) in 38 of 69 TACIs (55%), 50 of 171 PACIs (29%), and 20 of 236 LACIs or POCIs (8%) (P<0.001). Velocity in the A1 segment of the anterior cerebral artery was reversed in 12 of 69 TACIs (17%), 20 of 171 PACIs (12%), and 8 of 236 LACIs or POCIs (3%) (P<0.001). Basilar artery velocity was abnormal in 8 of 121 POCIs (7%) compared with 5 of 355 (1%) of the other subtypes (P=0.005). Vertebral artery velocity was abnormal (reduced velocity, @entity432 , @entity850 ) in 20 of 121 POCIs (17%) compared with 20 of 355 others (6%) (P=0.01). CONCLUSIONS: Intracranial @entity7244 were related to OCSP clinical subtype. Therefore, it is possible to stratify @entity1 according to OCSP classification in trials of new treatments in which treatment effectiveness may depend on the underlying pattern of arterial pathology and before any arterial imaging is available.

title: Relationship between pattern of intracranial XXXX on transcranial doppler and Oxfordshire @entity64 Project clinical classification of @entity385 .

answer: @entity7244 :: (MESH:D020765,Disease) :: ['artery abnormalities']


abstract: BACKGROUND AND PURPOSE: The Oxfordshire @entity64 Project (OCSP) devised a simple classification for acute @entity64 based on clinical features only, which is of value in predicting prognosis. We investigated whether the pattern of @entity1504 is related to the clinical syndrome. METHODS: @entity1 with acute @entity385 were classified by a @entity64 physician as having total or partial anterior circulation @entity1188 ( @entity24603 or PACI, respectively), @entity1188 ( @entity1188 ), or posterior circulation @entity1188 (POCI). Color-coded power transcranial Doppler was done whenever possible. Intracranial arterial velocities were compared in the 4 subtypes of @entity385 after adjustment for age and time to transcranial Doppler. RESULTS: Middle cerebral artery velocity was abnormal ( @entity450 , reduced velocity, @entity432 , or focal @entity850 ) in 38 of 69 TACIs (55%), 50 of 171 PACIs (29%), and 20 of 236 LACIs or POCIs (8%) (P<0.001). Velocity in the A1 segment of the anterior cerebral artery was reversed in 12 of 69 TACIs (17%), 20 of 171 PACIs (12%), and 8 of 236 LACIs or POCIs (3%) (P<0.001). Basilar artery velocity was abnormal in 8 of 121 POCIs (7%) compared with 5 of 355 (1%) of the other subtypes (P=0.005). Vertebral artery velocity was abnormal (reduced velocity, @entity432 , @entity850 ) in 20 of 121 POCIs (17%) compared with 20 of 355 others (6%) (P=0.01). CONCLUSIONS: Intracranial @entity7244 were related to OCSP clinical subtype. Therefore, it is possible to stratify @entity1 according to OCSP classification in trials of new treatments in which treatment effectiveness may depend on the underlying pattern of arterial pathology and before any arterial imaging is available.

title: Relationship between pattern of intracranial @entity7244 on transcranial doppler and Oxfordshire @entity64 Project clinical classification of XXXX .

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: BACKGROUND: Laparoscopic cholecystectomy is the treatment of choice for symptomatic @entity2963 . @entity282 , however, can prolong hospital stay and lead to increased morbidity. In the context of a multimodal approach to @entity1337 , intraperitoneal local anesthetic administration optimizes @entity1337 and facilitates early postoperative recovery, and it may be associated with a decreased risk of side effects. METHODS: A total of 71 @entity1 was randomized to receive either intraperitoneal analgesic ( @entity9348 group) or not (controls). At the completion of cholecystectomy, 10 mL of @entity1343 0.5% were infused intraperitoneally in the @entity9348 group and 8 h postoperatively, whereas in the controls, 10 mL of 0.9% @entity1219 were administered in the corresponding points of time. Differences in @entity158 scores between groups were the primary endpoints. Opioid consumption and adverse effects were the secondary endpoints. RESULTS: The 2 groups were homogenous in respect to age, sex, body mass index (BMI), and duration of operation. No conversion, complication, or mortality was recorded. The @entity9348 group had a lesser visual analog scale score at rest and at movement compared with controls at all points of time measured. Moreover, @entity3575 consumption in the recovery room was significantly greater in the control group, and the consumption of @entity6882 and the percentage of the @entity1 that requested rescue @entity1337 in the ward was significantly greater in the control group. Local analgesic intraperitoneal injection as well as @entity14340 for postoperative @entity1337 had no significant adverse effects. CONCLUSION: Our study showed that 2 separate doses of intraperitoneally administered @entity1343 significantly decreased @entity282 and the need for opioids compared with placebo. This technique is simple, safe, and without adverse effects.

title: Repeated intraperitoneal instillation of @entity1343 for the management of XXXX after laparoscopic cholecystectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity14340 :: ('MESH:C409945', 'Chemical') :: ['parecoxib']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis']

entities_list: @entity6882 :: ('MESH:D008614', 'Chemical') :: ['meperidine']

entities_list: @entity1343 :: ('MESH:C476513', 'Chemical') :: ['levobupivacaine']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain', 'Postoperative pain']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: BACKGROUND: Laparoscopic cholecystectomy is the treatment of choice for symptomatic @entity2963 . @entity282 , however, can prolong hospital stay and lead to increased morbidity. In the context of a multimodal approach to @entity1337 , intraperitoneal local anesthetic administration optimizes @entity1337 and facilitates early postoperative recovery, and it may be associated with a decreased risk of side effects. METHODS: A total of 71 @entity1 was randomized to receive either intraperitoneal analgesic ( @entity9348 group) or not (controls). At the completion of cholecystectomy, 10 mL of @entity1343 0.5% were infused intraperitoneally in the @entity9348 group and 8 h postoperatively, whereas in the controls, 10 mL of 0.9% @entity1219 were administered in the corresponding points of time. Differences in @entity158 scores between groups were the primary endpoints. Opioid consumption and adverse effects were the secondary endpoints. RESULTS: The 2 groups were homogenous in respect to age, sex, body mass index (BMI), and duration of operation. No conversion, complication, or mortality was recorded. The @entity9348 group had a lesser visual analog scale score at rest and at movement compared with controls at all points of time measured. Moreover, @entity3575 consumption in the recovery room was significantly greater in the control group, and the consumption of @entity6882 and the percentage of the @entity1 that requested rescue @entity1337 in the ward was significantly greater in the control group. Local analgesic intraperitoneal injection as well as @entity14340 for postoperative @entity1337 had no significant adverse effects. CONCLUSION: Our study showed that 2 separate doses of intraperitoneally administered @entity1343 significantly decreased @entity282 and the need for opioids compared with placebo. This technique is simple, safe, and without adverse effects.

title: Repeated intraperitoneal instillation of XXXX for the management of @entity158 after laparoscopic cholecystectomy.

answer: @entity1343 :: (MESH:C476513,Chemical) :: ['levobupivacaine']


abstract: Basiliximab induction treatment has been shown to reduce the incidence of acute rejection episodes without the secondary side effects observed with antilymphocyte polyclonal antibodies. We analyzed our experience with basiliximab induction associated with @entity1140 -based immunosuppression among low-immunological risk renal transplant recipients. We retrospectively analyzed 55 renal transplantation @entity1 of low inmunological risk who received organs from donors younger than 55 years. We compared a group of 21 @entity1 (38.9%; group 1) treated with basiliximab (Simulect, Novartis, Basel, Switzerland) with 33 @entity1 (61.1%; group 2) without induction. The @entity1 groups did not differ in recipient age (46.39 +/- 11.1 in group 1 vs 41.82 +/- 11.02 years in group 2; P = .25), donor age (36.71 +/- 14.72 vs 35.09 +/- 14.63 years; P = .69), or recipient and donor gender. No differences were observed in dose or @entity1140 levels during follow-up. The incidences of delayed graft function (DGF; 28.6% vs 28.1%; P = .97) and of acute rejection episodes (9.5% vs 15.6%; P = .52) were similar in both groups. Serum @entity1011 and proteinuria levels (P > .05) and hospital admissions due to @entity281 (36.4 vs 35.7%; P = .97) were also similar in both groups. At 1 year graft survival rates were 92% and 96% (P = .97) in groups 1 and 2, respectively. Considering our findings and the costs of basiliximab treatment, we conclude that routine administration of basiliximab cannot be justified in young, low-immunological risk transplant recipients undergoing @entity1140 -based immunosuppression.

title: Use of basiliximab induction in low-immunological risk renal transplant recipients receiving XXXX -based immunosuppression.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus']

answer: @entity1140 :: (MESH:D016559,Chemical) :: ['tacrolimus']