abstract: BACKGROUND: A recent study indicated the efficacy of the addition of @entity617 to intravenous immunoglobulin (IVIG) as initial treatment in @entity1 with higher risk of IVIG resistance. Several different risk scores for predicting IVIG resistance have been proposed mainly based on typical @entity573 ( @entity573 ) @entity1 . We investigated the utility of the risk scores to predict IVIG resistance with incomplete @entity573 . METHODS: Clinical records of incomplete @entity573 @entity1 who received a single dose of IVIG between 2005 and 2012 at our institute were retrospectively reviewed. @entity1 were classified into an IVIG-responsive group and an IVIG-resistant group. The Kobayashi, Egami, and Sano risk scores were calculated for each @entity1 and the proportion of high-risk @entity1 was compared between the two groups for each risk score. RESULTS: For 51 incomplete @entity573 @entity1 , Kobayashi (66.7% versus 47.6%, P   =   0.253), Egami (55.6% versus 38.1%, P   =   0.274), and Sano (57.1% versus 10.8%, P   =   0.068) risk scores identified a higher proportion of high-risk @entity1 in the IVIG-resistant group compared to the IVIG-responsive group, but significant difference was not observed. The Sano risk score showed the highest odds ratio (6.19, 95% confidence interval 1.00-38.26). CONCLUSIONS: The proportion of @entity1 identified as being at high-risk for IVIG resistance using the Kobayashi, Egami, and Sano risk scores, respectively, were not significantly different between the IVIG-responsive group and the IVIG-resistant group with incomplete @entity573 . Among the three risk scores, the Sano risk score has the best ability to predict IVIG resistance with incomplete @entity573 . This article is protected by copyright. All rights reserved.

title: Verification of risk scores to predict intravenous immunoglobulin resistance in incomplete XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity573 :: ('MESH:C537014', 'Disease') :: ['KD', 'Kawasaki disease']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

answer: @entity573 :: (MESH:C537014,Disease) :: ['Kawasaki disease']


abstract: UNASSIGNED: Background:Systemic inflammatory response (SIR) is important in the relationship between the @entity5 , the host, and outcome in @entity5 @entity1 . However, limited data exist regarding the prognostic significance of SIR in @entity150 . We investigate the utility of pretreatment SIR in @entity1 with @entity189 undergoing radical cystectomy.Methods:The study cohort consisted of 419 @entity1 with a median follow-up of 37.7 months. The SIRs used for each described prognostic nomogram are consistent with previously published data: @entity1851 , albumin, white cell count, neutrophil count, lymphocyte count, and platelet count. Primary end point was disease-specific survival (DSS) and @entity1349 ( @entity1349 ) after surgery. Cox regression models were used to determine the time to disease-specific and overall mortality. Multivariate regression coefficients of the predictors were used to develop nomograms for predicting 5-year DSS and @entity1349 probability.Results:Multivariate Cox regression analyses revealed that albumin, lymphocyte count, and platelet count were significantly associated with a significantly increased risk for @entity204 from @entity150 . The nomograms including each index were developed to predict the probability of 5-year DSS and @entity1349 after radical cystectomy. The C statistics were 77.8% and 77.3%, respectively, and exceeded the 2002 AJCC (72.0% and 70.3%, respectively). In the decision curve analyses, the nomograms including SIR demonstrated higher net benefit gains compared with the models without SIR.Conclusions:Cellular components of SIR have better prognostic values compared with acute-phase protein in @entity1 undergoing radical cystectomy for @entity150 .

title: The prognostic value of pretreatment of systemic inflammatory responses in @entity1 with XXXX undergoing radical cystectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity189 :: (MESH:D002277,Disease) :: ['urothelial carcinoma']


abstract: UNASSIGNED: Background:Systemic inflammatory response (SIR) is important in the relationship between the @entity5 , the host, and outcome in @entity5 @entity1 . However, limited data exist regarding the prognostic significance of SIR in @entity150 . We investigate the utility of pretreatment SIR in @entity1 with @entity189 undergoing radical cystectomy.Methods:The study cohort consisted of 419 @entity1 with a median follow-up of 37.7 months. The SIRs used for each described prognostic nomogram are consistent with previously published data: @entity1851 , albumin, white cell count, neutrophil count, lymphocyte count, and platelet count. Primary end point was disease-specific survival (DSS) and @entity1349 ( @entity1349 ) after surgery. Cox regression models were used to determine the time to disease-specific and overall mortality. Multivariate regression coefficients of the predictors were used to develop nomograms for predicting 5-year DSS and @entity1349 probability.Results:Multivariate Cox regression analyses revealed that albumin, lymphocyte count, and platelet count were significantly associated with a significantly increased risk for @entity204 from @entity150 . The nomograms including each index were developed to predict the probability of 5-year DSS and @entity1349 after radical cystectomy. The C statistics were 77.8% and 77.3%, respectively, and exceeded the 2002 AJCC (72.0% and 70.3%, respectively). In the decision curve analyses, the nomograms including SIR demonstrated higher net benefit gains compared with the models without SIR.Conclusions:Cellular components of SIR have better prognostic values compared with acute-phase protein in @entity1 undergoing radical cystectomy for @entity150 .

title: The prognostic value of pretreatment of systemic inflammatory responses in XXXX with @entity189 undergoing radical cystectomy.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: Preclinical imaging of @entity296 ( @entity296 ) can elucidate molecular mechanisms underlying @entity65 . We compared the repeatability and variability of two methods, first-pass MRI and arterial spin labeling (ASL), for imaging @entity296 in @entity19 . METHODS: Quantitative perfusion MRI in @entity19 was performed using both methods at rest, with a vasodilator, and one day after @entity583 . Image quality (score of 1-5; 5 best), between-session coefficient of variability (CVbs ), intra-user coefficient of variability (CVintra-user ), and inter-user coefficient of variability (CVinter-user ) were assessed. Acquisition time was 1-2 min for first-pass MRI and approximately 40 min for ASL. RESULTS: Image quality was higher for ASL (3.94        0.09 versus 2.88        0.10; P   <   0.05). Infarct zone CVbs was lower with first-pass (17        3% versus 46        9%; P   <   0.05). The stress perfusion CVintra-user was lower for ASL (3        1% versus 14        3%; P   <   0.05). The stress perfusion CVinter-user was lower for ASL (4        1% versus 17        4%; P   <   0.05). CONCLUSION: For low @entity296 conditions such as @entity1188 , first-pass MRI is preferred due to better repeatability and variability. At high @entity296 such as at vasodilation, ASL may be more suitable due to superior image quality and lower user variability. First-pass MRI has a substantial speed advantage. Magn Reson Med, 2015.    2015 Wiley Periodicals, Inc.

title: Repeatability and variability of myocardial perfusion imaging techniques in XXXX : Comparison of arterial spin labeling and first-pass contrast-enhanced MRI.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['MBF', 'myocardial blood flow']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: @entity4261 is a focal @entity2331 ; it is characterized by an accelerated rate of bone remodeling, with profound changes in the bone structure, making it fragile. This condition affects approximately 2% to 5% of the population older than 40. The main clinical manifestations of @entity4261 are @entity158 and @entity79 , although the majority of @entity1 are asymptomatic. @entity5144 is a @entity1691 with a prevalence of about 0,1%. It is characterized by the presence of @entity625 , @entity4932 and/or dactylitis associated with a familiar or personal history of @entity1569 . Several clinical patterns of joint involvement in @entity5144 have been identified, namely, the polyarticular pattern, similar to @entity309 . @entity625 precedes @entity272 in approximately 13 to 17 % of the cases. The authors report a clinical case of a 60 years old @entity1 with @entity625 and dactylitis who was diagnosed with @entity5144 and @entity4261 . The concomitance of the two entities, in the same individual, with so different pathogenesis and clinical features, have never been described on literature. Because of the complexity on the clinical and imaging evaluation as the result of the coexistence of both pathologies, the authors consider relevant to publish this singular case.

title: [ XXXX concomitant with Paget's Disease - A case report].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['polyarthritis', 'arthritis', 'Arthritis']

entities_list: @entity1569 :: ('MESH:D011565', 'Disease') :: ['psoriasis']

entities_list: @entity4261 :: ('MESH:D010001', 'Disease') :: ["Paget's disease of bone", "Paget's disease", 'Paget disease of bone']

entities_list: @entity5144 :: ('MESH:D015535', 'Disease') :: ['Psoriatic Arthritis', 'psoriatic arthritis']

entities_list: @entity4932 :: ('MESH:D001171', 'Disease') :: ['enthesitis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone deformity']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['disorder of bone metabolism']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['spondyloarthritis']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin disease']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

answer: @entity5144 :: (MESH:D015535,Disease) :: ['Psoriatic Arthritis']


abstract: OBJECTIVE: To describe successful termination of an outbreak of @entity2176 -resistant @entity6375 (VREfm) colonization within a neonatal service. SETTING: Multisite neonatal intensive care unit and special care nurseries within a single health care service. @entity1 : Forty-four cases of VREfm-colonized neonatal inpatients-including 2 clinical isolates (eye swab and catheter-urine specimen) and 42 screening isolates. INTERVENTIONS: Active surveillance cultures, @entity1 isolation, contact precautions, enhanced environment cleaning, and staff and parent education. Whole genome sequencing and multilocus sequence typing were used to characterize the outbreak and refine infection control procedures. RESULTS: Peak prevalence of VREfm colonization across all sites was 31% upon discovery of the outbreak. Subsequent to the intervention, transmission was halted within 8 weeks and no further isolates of the outbreak strain have been detected as of 12  months following outbreak cessation. Environmental swabs revealed VREfm colonization of baby-weighing scales, a baby bath, and a pharmacy refrigerator within the neonatal intensive care unit. All isolates were of a single multilocus sequence type (sequence type 796) and highly clonal at the core genome level. CONCLUSIONS: Bundled infection control interventions were effective in rapidly terminating a clonal outbreak of sequence type 796 VREfm colonization within a neonatal inpatient service. Strain-typing and active surveillance cultures were critical in guiding the management of this outbreak. The closed environment of a neonatal unit likely facilitated eradication of the @entity1 and environment reservoirs of VREfm colonization.

title: Outbreak of vanB XXXX -resistant @entity6375 colonization in a neonatal service.

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'patient']

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin']

entities_list: @entity6375 :: ('1352', 'Species') :: ['Enterococcus faecium']

answer: @entity2176 :: (MESH:D014640,Chemical) :: ['vancomycin']


abstract: OBJECTIVE: To describe successful termination of an outbreak of @entity2176 -resistant @entity6375 (VREfm) colonization within a neonatal service. SETTING: Multisite neonatal intensive care unit and special care nurseries within a single health care service. @entity1 : Forty-four cases of VREfm-colonized neonatal inpatients-including 2 clinical isolates (eye swab and catheter-urine specimen) and 42 screening isolates. INTERVENTIONS: Active surveillance cultures, @entity1 isolation, contact precautions, enhanced environment cleaning, and staff and parent education. Whole genome sequencing and multilocus sequence typing were used to characterize the outbreak and refine infection control procedures. RESULTS: Peak prevalence of VREfm colonization across all sites was 31% upon discovery of the outbreak. Subsequent to the intervention, transmission was halted within 8 weeks and no further isolates of the outbreak strain have been detected as of 12  months following outbreak cessation. Environmental swabs revealed VREfm colonization of baby-weighing scales, a baby bath, and a pharmacy refrigerator within the neonatal intensive care unit. All isolates were of a single multilocus sequence type (sequence type 796) and highly clonal at the core genome level. CONCLUSIONS: Bundled infection control interventions were effective in rapidly terminating a clonal outbreak of sequence type 796 VREfm colonization within a neonatal inpatient service. Strain-typing and active surveillance cultures were critical in guiding the management of this outbreak. The closed environment of a neonatal unit likely facilitated eradication of the @entity1 and environment reservoirs of VREfm colonization.

title: Outbreak of vanB @entity2176 -resistant XXXX colonization in a neonatal service.

answer: @entity6375 :: (1352,Species) :: ['Enterococcus faecium']


abstract: OBJECTIVE: To study the association of renal function with renal perfusion and renal parenchymal structure (T1 relaxation) in @entity1 with @entity712 ( @entity712 ). METHODS: After IRB approval, 40 @entity1 were enrolled according to @entity712 and renal function status [10 healthy volunteers   <   40  years; 10 healthy age-matched volunteers; 10 @entity712 @entity1 @entity470   >   60  ml/min/1.73  m(2); 10 @entity712 @entity1 @entity470   <   60  ml/min/1.73  m(2)] and assessed by MRI. To be eligible for enrolment all @entity712 @entity1 with @entity8 ( @entity8 ) needed to be diagnosed as having chronic @entity9136 based on current guidelines. @entity1 with primary @entity8 were excluded. RESULTS: Renal cortical perfusion correlated with @entity470 values (r   =   0.52;p   <   0.01) and was similar between @entity712 @entity1 with and without @entity8 (p   =   0.27). T1 relaxation correlated negatively with @entity470 values (r   =   -0.41;p   >   0.01) and was higher in @entity712 @entity1 compared to volunteers (1121        102  ms vs. 1054        65  ms;p   =   0.03). T1 relaxation was selectively prolonged in @entity712 @entity1 with @entity8 (1169  ms        100 vs. @entity712 without @entity8 1067  ms        79;p   =   0.047). In linear regression analyses @entity453 (p   =   0.01), @entity101 (p   =   0.04), and @entity6 (p   <   0.01) were associated with T1 relaxation. CONCLUSION: @entity8 in @entity712 is not primarily mediated by decreased renal perfusion. Instead, chronic reno- @entity8 , as indicated by prolonged T1 relaxation, appears to underly chronic @entity9136 . KEY POINTS:     The pathophysiology underlying chronic @entity9136 is not completely understood.     Chronic @entity9136 is independent of cardiac output or renal perfusion.     Renal T 1 relaxation appears to be prolonged in @entity712 with @entity8 .     Renal T 1 relaxation is associated with classic cardiovascular risk factors.     Association of renal T 1 relaxation with @entity8 should be validated further.

title: The pathophysiology of the chronic XXXX : a magnetic resonance imaging study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients']

entities_list: @entity9136 :: ('MESH:D059347', 'Disease') :: ['cardiorenal syndrome']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['RD', 'renal impairment', 'parenchymal damage', 'renal dysfunction', 'kidney disease']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'chronic heart failure']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

answer: @entity9136 :: (MESH:D059347,Disease) :: ['cardiorenal syndrome']


abstract: OBJECTIVE: To utilise an exposed/unexposed cohort strategy for mortality and @entity5 analyses across unselected and complete cohorts of @entity1 with @entity5442 ( @entity5442 ) resident in south-east Norway (denominator population 2.6 million), between 2003 and 2012. METHOD: @entity5442 cases were identified by comprehensive searches through @entity1 administrative databases followed by manual chart review. @entity6558 ( @entity6558 ) and @entity6017 ( @entity6017 ) cases were classified by the Peter and Bohan and/or Targoff diagnostic criteria and @entity5589 ( @entity5589 ) by the European NeuroMuscular Centre (ENMC) criteria from 1997 and/or 2011. Every @entity1 was matched for sex, age and residential area with 15 unexposed/non- @entity5442 individuals drawn from the national population registry. RESULTS: Total mortality in the @entity5442 cohort was 27% (87/326). Standardized mortality rate (SMR) was higher in @entity6017 (2.6) than @entity6558 (2.4) and @entity5589 (1.7). @entity5442 -related causes of @entity204 were frequent (64%) and included @entity5 (all @entity5442 subsets), aspiration ( @entity5589 ), @entity358 ( @entity6558 / @entity6017 ) and infections ( @entity6558 / @entity6017 ). Multivariate analyses identified age at diagnosis ( @entity6558 and @entity5589 ), positive anti-SSA ( @entity6558 ), @entity5 ( @entity6017 ), and DLCO < 60% ( @entity6017 ) as independent mortality risk factors. @entity5 risk was increased in @entity6017 (standard incidence rate 2.0) and @entity6558 (SIR = 1.3), but not in @entity5589 (SIR = 0.9). @entity43 was more prevalent in @entity6017 than in the general population (8.3% vs 1.1%). CONCLUSION: Our results suggest that mortality rates and @entity5 risk remain elevated in @entity6017 , and to a lesser degree also in @entity6558 . Mortality rate was also increased in @entity5589 , but some @entity204 appeared to be due to potentially preventable causes.

title: Survival and @entity5 risk in an unselected and complete Norwegian XXXX cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Ovarian cancer']

entities_list: @entity6017 :: ('MESH:D003882', 'Disease') :: ['dermatomyositis', 'DM']

entities_list: @entity5442 :: ('MESH:D009220', 'Disease') :: ['idiopathic inflammatory myopathy', 'IIM']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications']

entities_list: @entity5589 :: ('MESH:D018979', 'Disease') :: ['sIBM', 'sporadic inclusion body myositis']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths', 'death']

entities_list: @entity6558 :: ('MESH:D017285', 'Disease') :: ['Polymyositis', 'PM']

answer: @entity5442 :: (MESH:D009220,Disease) :: ['idiopathic inflammatory myopathy']


abstract: OBJECTIVE: To utilise an exposed/unexposed cohort strategy for mortality and @entity5 analyses across unselected and complete cohorts of @entity1 with @entity5442 ( @entity5442 ) resident in south-east Norway (denominator population 2.6 million), between 2003 and 2012. METHOD: @entity5442 cases were identified by comprehensive searches through @entity1 administrative databases followed by manual chart review. @entity6558 ( @entity6558 ) and @entity6017 ( @entity6017 ) cases were classified by the Peter and Bohan and/or Targoff diagnostic criteria and @entity5589 ( @entity5589 ) by the European NeuroMuscular Centre (ENMC) criteria from 1997 and/or 2011. Every @entity1 was matched for sex, age and residential area with 15 unexposed/non- @entity5442 individuals drawn from the national population registry. RESULTS: Total mortality in the @entity5442 cohort was 27% (87/326). Standardized mortality rate (SMR) was higher in @entity6017 (2.6) than @entity6558 (2.4) and @entity5589 (1.7). @entity5442 -related causes of @entity204 were frequent (64%) and included @entity5 (all @entity5442 subsets), aspiration ( @entity5589 ), @entity358 ( @entity6558 / @entity6017 ) and infections ( @entity6558 / @entity6017 ). Multivariate analyses identified age at diagnosis ( @entity6558 and @entity5589 ), positive anti-SSA ( @entity6558 ), @entity5 ( @entity6017 ), and DLCO < 60% ( @entity6017 ) as independent mortality risk factors. @entity5 risk was increased in @entity6017 (standard incidence rate 2.0) and @entity6558 (SIR = 1.3), but not in @entity5589 (SIR = 0.9). @entity43 was more prevalent in @entity6017 than in the general population (8.3% vs 1.1%). CONCLUSION: Our results suggest that mortality rates and @entity5 risk remain elevated in @entity6017 , and to a lesser degree also in @entity6558 . Mortality rate was also increased in @entity5589 , but some @entity204 appeared to be due to potentially preventable causes.

title: Survival and XXXX risk in an unselected and complete Norwegian @entity5442 cohort.

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: PURPOSE: This study was designed to compare quality of life in a sample of Italian @entity1 affected by @entity902 -sensitive recurrent @entity43 and submitted to chemotherapy alone or secondary cytoreductive surgery plus chemotherapy through validated questionnaires. METHODS: From January 2007 to December 2012, consecutive @entity1 with suspicious recurrence of @entity43 , referred to the Division of Gynecologic Oncology at the University Campus Bio-Medico of Rome, were assessed for this prospective, case-control study. After a diagnostic laparoscopy, surgical resectable @entity1 were enrolled in group A (surgery plus chemotherapy). @entity1 not suitable for optimal debulking surgery and all @entity1 who refused surgery were enrolled in group B (chemotherapy alone). At beginning of treatment, after the third and sixth cycle of chemotherapy, all eligible @entity1 were asked to fill in QLQ-C30 (version 3.0) and EORTC QLQ-OV28 questionnaires. RESULTS: Group A included 38 @entity1 and underwent @entity4886 followed by chemotherapy; group B included 16 @entity1 that were submitted to chemotherapy alone. Quality-of-life scores of both questionnaires were comparable between groups, with the exception of @entity1142 and @entity158 , which resulted significantly worsened in Group A at 3  months. This difference was no longer present at 6  months. Median overall survival was 72  % for Group A and 56  % in Group B at median follow-up of 35  months for Group A and 32  months for Group B. CONCLUSIONS: Both surgery followed by chemotherapy and chemotherapy alone seem to have a negligible impact on QOL. @entity4886 plus chemotherapy seems to be an effective and tolerable therapeutic option in @entity902 -sensitive recurrences.

title: Quality of Life in @entity902 -Sensitive Recurrent XXXX : Chemotherapy Versus Surgery Plus Chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity43 :: (MESH:D010051,Disease) :: ['Ovarian Cancer']


abstract: PURPOSE: This study was designed to compare quality of life in a sample of Italian @entity1 affected by @entity902 -sensitive recurrent @entity43 and submitted to chemotherapy alone or secondary cytoreductive surgery plus chemotherapy through validated questionnaires. METHODS: From January 2007 to December 2012, consecutive @entity1 with suspicious recurrence of @entity43 , referred to the Division of Gynecologic Oncology at the University Campus Bio-Medico of Rome, were assessed for this prospective, case-control study. After a diagnostic laparoscopy, surgical resectable @entity1 were enrolled in group A (surgery plus chemotherapy). @entity1 not suitable for optimal debulking surgery and all @entity1 who refused surgery were enrolled in group B (chemotherapy alone). At beginning of treatment, after the third and sixth cycle of chemotherapy, all eligible @entity1 were asked to fill in QLQ-C30 (version 3.0) and EORTC QLQ-OV28 questionnaires. RESULTS: Group A included 38 @entity1 and underwent @entity4886 followed by chemotherapy; group B included 16 @entity1 that were submitted to chemotherapy alone. Quality-of-life scores of both questionnaires were comparable between groups, with the exception of @entity1142 and @entity158 , which resulted significantly worsened in Group A at 3  months. This difference was no longer present at 6  months. Median overall survival was 72  % for Group A and 56  % in Group B at median follow-up of 35  months for Group A and 32  months for Group B. CONCLUSIONS: Both surgery followed by chemotherapy and chemotherapy alone seem to have a negligible impact on QOL. @entity4886 plus chemotherapy seems to be an effective and tolerable therapeutic option in @entity902 -sensitive recurrences.

title: Quality of Life in XXXX -Sensitive Recurrent @entity43 : Chemotherapy Versus Surgery Plus Chemotherapy.

answer: @entity902 :: (MESH:D010984,Chemical) :: ['Platinum']


abstract: UNASSIGNED: @entity880 (LA) accumulates under inflammatory conditions, e.g. in wounds or @entity5 , and influences local immune cell functions. We previously noted inhibitory effects of LA on glycolysis and @entity310 secretion of @entity1 @entity558 -stimulated monocytes. Here, we globally analyze the influence of LA on gene expression during monocyte activation. To separate LA-specific from @entity880 - or pH-effects, monocytes were treated for one or four hours with @entity558 in the presence of physiological concentrations of LA, @entity19794 (NaL) or acidic pH. Analyses of global gene expression profiles revealed striking effects of LA during the early stimulation phase. Up-regulation of most @entity558 -induced genes was significantly delayed in the presence of LA, while this inhibitory effect was attenuated in acidified samples and not detected after incubation with NaL. LA targets included genes encoding for important monocyte effector proteins like cytokines (e.g. @entity310 and @entity4452 ) or chemokines (e.g. @entity2842 and @entity7721 ). LA effects were validated for several targets by quantitative RT-PCR and/or ELISA. Further analysis of @entity558 -signaling pathways revealed that LA delayed the phosphorylation of protein kinase B ( @entity584 ) as well as the degradation of @entity4284 . Consistently, the @entity558 -induced nuclear accumulation of NFkB was also diminished in response to LA. These results indicate that the broad effect of LA on gene expression and function of @entity1 monocytes is at least partially caused by its interference with immediate signal transduction events after activation. This mechanism might contribute to monocyte suppression in the @entity5 environment.

title: Lactic acid delays the inflammatory response of XXXX monocytes.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate', 'Lactic acid']

entities_list: @entity19794 :: ('MESH:D019354', 'Chemical') :: ['sodium lactate']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: Although joint-preserving surgery for intermediate @entity3681 has been reported to be effective, failures of supramalleolar osteotomy and plafond-plasty can occur because of persistent @entity893 of the distal tibia and incongruent ankle mortise. We introduce a novel opening wedge distal tibial osteotomy procedure (mortise-plasty) with rigid plate fixation combined with synthetic bone wedges. We performed 27 mortise-plasties in 25 @entity1 with @entity3681 and instability. Six males (24%) and 19 females (76%), with a mean age of 63 (range 28 to 79) years, were followed up for a mean of 27.3 (range 14 to 45) months. The mean preoperative visual analog scale score, American Orthopaedic Foot and Ankle Society score, and Takakura ankle scale score were 7.4 (range 5.4 to 10), 58.7 (range 18 to 84), and 55.9 (range 29 to 88), respectively. These scores improved significantly to 2.1 (range 0 to 6.5), 89.3 (range 67 to 100), and 84.7 (range 55 to 100) postoperatively (p  <  .001). The mean preoperative tibial-anterior surface angle and talar tilt angle were 84.9   (range 78   to 90  ) and 8.3   (range 3   to 21  ), respectively. At the most recent follow-up visit, the corresponding values were 95.0   (range 82   to 99  ) and 1.8   (range 0   to 8  ), respectively (p  <  .001). Computed tomography scans indicated that the ankle mortise narrowed by approximately 1.8  mm and the tibial plafond was lowered after osteotomy. No @entity1 underwent lateral ligament reconstruction, ankle joint replacement, or arthrodesis. Mortise-plasty osteotomy corrects the intra-articular and extra-articular deformities simultaneously and provides good clinical and radiographic outcomes for @entity1 with @entity3681 and instability.

title: Treatment of XXXX and Instability With a Novel Mortise-Plasty Osteotomy Procedure.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity893 :: ('MESH:D017760', 'Disease') :: ['malalignment']

entities_list: @entity3681 :: ('MESH:D016512', 'Disease') :: ['varus ankle osteoarthritis', 'ankle osteoarthritis']

answer: @entity3681 :: (MESH:D016512,Disease) :: ['Varus Ankle Osteoarthritis']


abstract: Cases of @entity2259 caused by anaerobic microorganisms and occurring during a four year period in a non-selected @entity1 group in a Spanish general hospital were analysed retrospectively. Microbiological data was collected on 212 @entity1 and clinical data on 103 @entity1 . Cases of anaerobic @entity2259 represented 8.6% of the total number of cases of @entity2259 . Of the 232 anaerobic microorganisms causing @entity2259 , gram-negative bacilli were responsible in 113 cases (48.7%), gram-positive bacilli in 92 cases (39.6%), gram-positive cocci in 25 cases (10.7%), and Veillonella @entity5645 . in two cases (0.8%). The most important clinical features were @entity221 (64%), @entity417 (56%), @entity326 (22%) and metastatic abscesses (21%). @entity1 with anaerobic @entity2259 were hospitalized for an average of 51.7 days. The overall mortality was 32% and factors associated with poor prognosis were severe underlying disease, nosocomial acquisition, presence of shock, presence of metastatic foci of @entity281 , and absence of adequate surgical drainage. The mortality rate of @entity1 who received adequate antimicrobial therapy was 30% and that of @entity1 who received inadequate treatment or none was 29%. It is concluded that anaerobic @entity2259 has a significant rate of morbidity and mortality and that underlying disease and surgical debridement and/or drainage have greater prognostic significance than the use of antimicrobial agents.

title: Retrospective analysis of two hundred and twelve cases of XXXX due to anaerobic microorganisms.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']

answer: @entity2259 :: (MESH:D016470,Disease) :: ['bacteremia']


abstract: In the search for novel potent fungi-derived bioactive compounds for bioinsecticide applications, crude @entity1046 culture filtrate extracts from 110 mangrove fungal endophytes were screened for their @entity137 . @entity137 tests of all extracts against brine shrimp (Artemia salina) larvae were performed. The extracts with the highest @entity137 were further examined for insecticidal activity against Spodoptera litura larvae and acetylcholinesterase (AChE) inhibition activity. The results showed that the extracts of five isolates exhibited the highest @entity137 to brine shrimp at 50% lethal concentration (LC50) values of 7.45 to 10.24 ppm. These five fungal isolates that obtained from Rhizophora mucronata were identified based on sequence data analysis of the internal transcribed spacer region of rDNA as @entity12799 BPPTCC 6036), @entity14940 (strains BPPTCC 6035 and BPPTCC 6038), A. tamarii (strain BPPTCC 6037), and A. versicolor (strain BPPTCC 6039). The mean percentage of S. litura larval mortality following topical application of the five extracts ranged from 16.7% to 43.3%. In the AChE inhibition assay, the inhibition rates of the five extracts ranged from 40.7% to 48.9%, while @entity2607 (positive control) had an inhibition rate of 96.8%, at a concentration of 100 ppm. The extracts used were crude extracts, so their potential as sources of AChE inhibition compounds makes them likely candidates as neurotoxins. The high-performance liquid chromatography profiles of the five extracts differed, indicating variations in their chemical constituents. This study highlights the potential of culture filtrate @entity1046 extracts of mangrove fungal endophytes as a source of new potential bioactive compounds for bioinsecticide applications.

title: Insecticidal Activity of XXXX Extracts from Culture Filtrates of Mangrove Fungal Endophytes.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity']

entities_list: @entity1046 :: ('MESH:C007650', 'Chemical') :: ['ethyl acetate']

entities_list: @entity14940 :: ('162425', 'Species') :: ['Emericella nidulans']

entities_list: @entity12799 :: ('5062', 'Species') :: ['Aspergillus oryzae (strain']

answer: @entity1046 :: (MESH:C007650,Chemical) :: ['Ethyl Acetate']


abstract: @entity647 ( @entity647 ) is an acute @entity55 that causes morbidity and mortality in critically ill @entity1 . However, there are many instances where @entity647 resolves spontaneously through endogenous pathways that help to control @entity55 . Previous studies have implicated the extracellular signaling molecule @entity859 and signaling events through the A2B @entity859 receptor in lung protection. In this context, we hypothesized that tissue-specific expression of the A2B @entity859 receptor is responsible for the previously described attenuation of @entity647 . To address this hypothesis, we exposed @entity19 with tissue-specific deletion of @entity23925 to @entity647 , utilizing a two-hit model where intratracheal LPS treatment is followed by injurious mechanical ventilation. Interestingly, a head-to-head comparison of @entity19 with deletion of @entity23925 in the myeloid lineage ( @entity23925 (loxP/loxP) @entity30562 Cre(+)), endothelial cells ( @entity23925 (loxP/loxP) @entity7112 Cre(+)), or alveolar epithelial cells ( @entity23925 (loxP/loxP) SPC Cre(+)) revealed a selective increase in disease susceptibility in @entity23925 (loxP/loxP) SPC Cre(+) @entity19 . More detailed analysis of @entity23925 (loxP/loxP) SPC Cre(+) @entity19 confirmed @entity55 and attenuated alveolar fluid clearance. To directly deliver an A2B @entity859 receptor-specific agonist to alveolar epithelial cells, we subsequently performed studies with inhaled @entity24980 . Indeed, aerosolized @entity24980 treatment was associated with @entity3126 , improved histologic @entity651 , and dampened @entity55 . Collectively, these findings suggest that alveolar epithelial A2B @entity859 receptor signaling contributes to lung protection, and they implicate inhaled A2B @entity859 receptor agonists in @entity647 treatment.

title: Alveolar Epithelial A2B @entity859 Receptors in Pulmonary Protection during Acute XXXX .

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['attenuated pulmonary edema']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['elevated lung inflammation', 'excessive lung inflammation', 'lung inflammation', 'inflammatory lung disease']

entities_list: @entity651 :: ('MESH:D055370', 'Disease') :: ['lung injury']

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['ALI', 'Acute lung injury']

answer: @entity651 :: (MESH:D055370,Disease) :: ['Lung Injury']


abstract: @entity647 ( @entity647 ) is an acute @entity55 that causes morbidity and mortality in critically ill @entity1 . However, there are many instances where @entity647 resolves spontaneously through endogenous pathways that help to control @entity55 . Previous studies have implicated the extracellular signaling molecule @entity859 and signaling events through the A2B @entity859 receptor in lung protection. In this context, we hypothesized that tissue-specific expression of the A2B @entity859 receptor is responsible for the previously described attenuation of @entity647 . To address this hypothesis, we exposed @entity19 with tissue-specific deletion of @entity23925 to @entity647 , utilizing a two-hit model where intratracheal LPS treatment is followed by injurious mechanical ventilation. Interestingly, a head-to-head comparison of @entity19 with deletion of @entity23925 in the myeloid lineage ( @entity23925 (loxP/loxP) @entity30562 Cre(+)), endothelial cells ( @entity23925 (loxP/loxP) @entity7112 Cre(+)), or alveolar epithelial cells ( @entity23925 (loxP/loxP) SPC Cre(+)) revealed a selective increase in disease susceptibility in @entity23925 (loxP/loxP) SPC Cre(+) @entity19 . More detailed analysis of @entity23925 (loxP/loxP) SPC Cre(+) @entity19 confirmed @entity55 and attenuated alveolar fluid clearance. To directly deliver an A2B @entity859 receptor-specific agonist to alveolar epithelial cells, we subsequently performed studies with inhaled @entity24980 . Indeed, aerosolized @entity24980 treatment was associated with @entity3126 , improved histologic @entity651 , and dampened @entity55 . Collectively, these findings suggest that alveolar epithelial A2B @entity859 receptor signaling contributes to lung protection, and they implicate inhaled A2B @entity859 receptor agonists in @entity647 treatment.

title: Alveolar Epithelial A2B XXXX Receptors in Pulmonary Protection during Acute @entity651 .

answer: @entity859 :: (MESH:D000241,Chemical) :: ['Adenosine']


abstract: OBJECTIVE: @entity3594 ( @entity3594 ) has been closely associated with @entity28 . @entity308 has also been shown to be disproportionally prevalent among @entity28 @entity1 . However, there is still a paucity of studies on the relationship between @entity308 and @entity3594 in @entity28 @entity1 . This study examined the difference in @entity209 and @entity308 between @entity28 and @entity28 -related @entity3594 . METHODS: A total of 88 @entity28 @entity1 treated in our department were selected for analysis. They were divided into @entity28 (OB n=30) and @entity28 with acanthosis nigricans ( @entity3594 n=58). A control (CON) group included 56 normal weight healthy volunteers. The self-administrated Beck @entity308 Inventory-II questionnaire was used. General characteristics and clinical data were collected for analysis. RESULTS: The frequency of @entity308 was recorded as 67.2% in the @entity3594 group, 43.4% in the OB group, and 3.6% in the CON group (P <0.001). The severity of @entity308 in the @entity3594 group was significantly higher than in the OB group and CON group (P <0.001). @entity1 with moderate @entity308 had higher levels of inflammatory markers than those with mild symptoms @entity308 . Free @entity844 (FFA) and @entity414 (UA) level in the @entity3594 group were significantly increased compared with the OB group (P=0.010, P=0.020). Discrimination was associated with @entity308 (P <0.001). CONCLUSION: @entity28 @entity1 had a higher risk of @entity308 , which were even higher in @entity1 with @entity3594 . @entity3594 is associated with more @entity308 status. Psychological intervention should be started early to prevent further physical and pathological @entity28 @entity1 , especially @entity28 @entity1 with @entity3594 .

title: Evaluation of XXXX in @entity28 @entity1 with or without acanthosis nigricans.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'people']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms and high inflammation', 'Depression', 'depressive symptoms', 'depression']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['impairment in obese', 'Obese', 'obese', 'obesity', 'simple obesity']

entities_list: @entity3594 :: ('MESH:D000052', 'Disease') :: ['AN', 'Acanthosis nigricans']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms']


abstract: OBJECTIVE: @entity3594 ( @entity3594 ) has been closely associated with @entity28 . @entity308 has also been shown to be disproportionally prevalent among @entity28 @entity1 . However, there is still a paucity of studies on the relationship between @entity308 and @entity3594 in @entity28 @entity1 . This study examined the difference in @entity209 and @entity308 between @entity28 and @entity28 -related @entity3594 . METHODS: A total of 88 @entity28 @entity1 treated in our department were selected for analysis. They were divided into @entity28 (OB n=30) and @entity28 with acanthosis nigricans ( @entity3594 n=58). A control (CON) group included 56 normal weight healthy volunteers. The self-administrated Beck @entity308 Inventory-II questionnaire was used. General characteristics and clinical data were collected for analysis. RESULTS: The frequency of @entity308 was recorded as 67.2% in the @entity3594 group, 43.4% in the OB group, and 3.6% in the CON group (P <0.001). The severity of @entity308 in the @entity3594 group was significantly higher than in the OB group and CON group (P <0.001). @entity1 with moderate @entity308 had higher levels of inflammatory markers than those with mild symptoms @entity308 . Free @entity844 (FFA) and @entity414 (UA) level in the @entity3594 group were significantly increased compared with the OB group (P=0.010, P=0.020). Discrimination was associated with @entity308 (P <0.001). CONCLUSION: @entity28 @entity1 had a higher risk of @entity308 , which were even higher in @entity1 with @entity3594 . @entity3594 is associated with more @entity308 status. Psychological intervention should be started early to prevent further physical and pathological @entity28 @entity1 , especially @entity28 @entity1 with @entity3594 .

title: Evaluation of @entity308 in XXXX @entity1 with or without acanthosis nigricans.

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: OBJECTIVE: @entity3594 ( @entity3594 ) has been closely associated with @entity28 . @entity308 has also been shown to be disproportionally prevalent among @entity28 @entity1 . However, there is still a paucity of studies on the relationship between @entity308 and @entity3594 in @entity28 @entity1 . This study examined the difference in @entity209 and @entity308 between @entity28 and @entity28 -related @entity3594 . METHODS: A total of 88 @entity28 @entity1 treated in our department were selected for analysis. They were divided into @entity28 (OB n=30) and @entity28 with acanthosis nigricans ( @entity3594 n=58). A control (CON) group included 56 normal weight healthy volunteers. The self-administrated Beck @entity308 Inventory-II questionnaire was used. General characteristics and clinical data were collected for analysis. RESULTS: The frequency of @entity308 was recorded as 67.2% in the @entity3594 group, 43.4% in the OB group, and 3.6% in the CON group (P <0.001). The severity of @entity308 in the @entity3594 group was significantly higher than in the OB group and CON group (P <0.001). @entity1 with moderate @entity308 had higher levels of inflammatory markers than those with mild symptoms @entity308 . Free @entity844 (FFA) and @entity414 (UA) level in the @entity3594 group were significantly increased compared with the OB group (P=0.010, P=0.020). Discrimination was associated with @entity308 (P <0.001). CONCLUSION: @entity28 @entity1 had a higher risk of @entity308 , which were even higher in @entity1 with @entity3594 . @entity3594 is associated with more @entity308 status. Psychological intervention should be started early to prevent further physical and pathological @entity28 @entity1 , especially @entity28 @entity1 with @entity3594 .

title: Evaluation of @entity308 in @entity28 XXXX with or without acanthosis nigricans.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIM: To investigate the clinical and social correlates of a lifetime history of crime victimization among first-episode @entity716 @entity1 at entry to an Early Intervention Service and following 18 months of specialist care. METHODS: Face-to-face interviews were conducted with 149 individuals who presented to an Early Intervention Service for the first time with @entity716 in the London borough of Lambeth, UK. A range of demographic and clinical measures were completed including self-reported history of victimization along with the type of crime and its subjective effect on the @entity1 . Clinical and functional outcomes at 18-month follow up were ascertained from clinical case notes by a psychiatrist. RESULTS: A large proportion of @entity1 (n   =   64, 43%) reported a history of crime victimization. This was associated with significantly higher levels of @entity308 and substance misuse at initial presentation. Being a victim of a crime was not significantly associated with poorer clinical or functional outcomes after 18 months of specialist care. However, non-significant differences were found for those who reported crime victimization in terms of their increased use of illegal substances or having assaulted someone else during the follow-up period. CONCLUSION: Past experience of being a victim of crime appears to be common in @entity1 presenting for the first time with @entity716 and is associated with increased likelihood of comorbidity. Thus, Early Intervention Services should consider screening for past victimization and be prepared to deal with comorbid problems. The impact of crime victimization on clinical and functional outcomes requires investigation over a longer period of time.

title: Impact of crime victimization on initial presentation to an early intervention for XXXX service and 18-month outcomes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

answer: @entity716 :: (MESH:D011605,Disease) :: ['psychosis']


abstract: OBJECTIVES: @entity1 who undergo lung resection surgery are at risk for postoperative morbidity and mortality. Appropriate selection of the surgical candidate is crucial in the treatment of @entity2 . Heart rate recovery is a measure of physical fitness. We aimed to investigate the association of impaired heart rate recovery with @entity532 after lung resection surgery for treatment of @entity2 . METHODS: Data from consecutive @entity1 who, between 2009 and 2013, underwent heart rate recovery evaluation after 6-minute walk tests before lung resection surgery were retrospectively reviewed. Impaired heart rate recovery was defined as a 12-beat or less decrease in peak heart rate at 1 minute after the 6-minute walk test. @entity260 were as defined by the Society of Thoracic Surgeons General Thoracic Surgery Database. Logistic regression was performed, including previously known risk factors for @entity260 after lung resection surgery. RESULTS: A total of 96 @entity1 had heart rate recovery evaluated within 6 months of lung resection surgery for treatment of @entity2 . Thirty-one @entity1 had impaired heart rate recovery, 17 of whom (55%) had @entity532 . A total of 65 @entity1 had normal heart rate recovery, 17 of whom (26%) had @entity532 . In multivariable logistic regression analysis, impaired heart rate recovery was significantly associated with @entity260 (odds ratio, 4.97; confidence interval, 1.79-13.8; P  =  .002). No @entity1 died within 30 days after surgery. CONCLUSIONS: Impaired heart rate recovery after the 6-minute walk test is associated with @entity260 in @entity1 who underwent lung resection surgery for treatment of @entity2 .

title: Association of impaired heart rate recovery with @entity532 after XXXX resection surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['cardiopulmonary complications']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative cardiopulmonary complications', 'postoperative complications', 'Postoperative cardiopulmonary complications']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: OBJECTIVES: @entity1 who undergo lung resection surgery are at risk for postoperative morbidity and mortality. Appropriate selection of the surgical candidate is crucial in the treatment of @entity2 . Heart rate recovery is a measure of physical fitness. We aimed to investigate the association of impaired heart rate recovery with @entity532 after lung resection surgery for treatment of @entity2 . METHODS: Data from consecutive @entity1 who, between 2009 and 2013, underwent heart rate recovery evaluation after 6-minute walk tests before lung resection surgery were retrospectively reviewed. Impaired heart rate recovery was defined as a 12-beat or less decrease in peak heart rate at 1 minute after the 6-minute walk test. @entity260 were as defined by the Society of Thoracic Surgeons General Thoracic Surgery Database. Logistic regression was performed, including previously known risk factors for @entity260 after lung resection surgery. RESULTS: A total of 96 @entity1 had heart rate recovery evaluated within 6 months of lung resection surgery for treatment of @entity2 . Thirty-one @entity1 had impaired heart rate recovery, 17 of whom (55%) had @entity532 . A total of 65 @entity1 had normal heart rate recovery, 17 of whom (26%) had @entity532 . In multivariable logistic regression analysis, impaired heart rate recovery was significantly associated with @entity260 (odds ratio, 4.97; confidence interval, 1.79-13.8; P  =  .002). No @entity1 died within 30 days after surgery. CONCLUSIONS: Impaired heart rate recovery after the 6-minute walk test is associated with @entity260 in @entity1 who underwent lung resection surgery for treatment of @entity2 .

title: Association of impaired heart rate recovery with XXXX after @entity2 resection surgery.

answer: @entity532 :: (MESH:D003925,Disease) :: ['cardiopulmonary complications']


abstract: INTRODUCTION: @entity1637 ( @entity1637 ) are rare @entity1374 . To date, capsular and/or vascular invasion are the only findings predicting @entity5 . Recently, mutation of 19p13, encoding two proteins involved in cell proliferation and apoptosis ( @entity59843 and @entity4452 ), has been described. The aim of our study is to evaluate the cellular proliferation index (Ki67), @entity59843 and @entity4452 expression as diagnostic markers of @entity5 in HCT. MATERIALS AND METHODS: Eighty @entity1 with HCT (32 @entity189 , 48 @entity652 ) whom underwent surgery in our center were included. Samples of both @entity1313 and adjacent normal thyroid tissue were analyzed by means of tissue micro-arrays. Correlations between expressions of Ki67, @entity59843 and @entity4452 and final histology were analyzed. RESULTS: Mean size of the lesion was higher in @entity189 than in @entity652 (p  =  0.01). @entity59843 and @entity4452 were significantly underexpressed in Hurthle cells @entity5 compared to normal tissue (p  =  0.0004 and p  =  0.0001, respectively). Ki67 and @entity59843 were, respectively, higher and down-expressed in @entity189 compared to @entity652 (p  =  0.0004 and p  =  0.005, respectively). On multivariate analysis, size correlates with @entity189 diagnosis. Neither @entity59843 nor Ki67 index was related to size. The expression of @entity4452 was reduced in both @entity2513 but differences were not statistically significant (p  =  0.13). CONCLUSIONS: Our study suggest that Ki67 and @entity59843 correlate with @entity5 in HCT. The expression of @entity4452 is down-regulated in HCT, but it is not diagnostic of @entity189 . Ki67 and @entity59843 may potentially help as cytological markers of @entity5 in HCT.

title: Thyroid H  rthle cell XXXX : research of potential markers of @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1637 :: ('MESH:D018249', 'Disease') :: ['HCTs', 'Hurthle cell tumors']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid neoplasia']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['neoplastic lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma']

entities_list: @entity2513 :: ('MESH:C563365', 'Disease') :: ['adenoma and carcinoma']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumors']


abstract: INTRODUCTION: @entity1637 ( @entity1637 ) are rare @entity1374 . To date, capsular and/or vascular invasion are the only findings predicting @entity5 . Recently, mutation of 19p13, encoding two proteins involved in cell proliferation and apoptosis ( @entity59843 and @entity4452 ), has been described. The aim of our study is to evaluate the cellular proliferation index (Ki67), @entity59843 and @entity4452 expression as diagnostic markers of @entity5 in HCT. MATERIALS AND METHODS: Eighty @entity1 with HCT (32 @entity189 , 48 @entity652 ) whom underwent surgery in our center were included. Samples of both @entity1313 and adjacent normal thyroid tissue were analyzed by means of tissue micro-arrays. Correlations between expressions of Ki67, @entity59843 and @entity4452 and final histology were analyzed. RESULTS: Mean size of the lesion was higher in @entity189 than in @entity652 (p  =  0.01). @entity59843 and @entity4452 were significantly underexpressed in Hurthle cells @entity5 compared to normal tissue (p  =  0.0004 and p  =  0.0001, respectively). Ki67 and @entity59843 were, respectively, higher and down-expressed in @entity189 compared to @entity652 (p  =  0.0004 and p  =  0.005, respectively). On multivariate analysis, size correlates with @entity189 diagnosis. Neither @entity59843 nor Ki67 index was related to size. The expression of @entity4452 was reduced in both @entity2513 but differences were not statistically significant (p  =  0.13). CONCLUSIONS: Our study suggest that Ki67 and @entity59843 correlate with @entity5 in HCT. The expression of @entity4452 is down-regulated in HCT, but it is not diagnostic of @entity189 . Ki67 and @entity59843 may potentially help as cytological markers of @entity5 in HCT.

title: Thyroid H  rthle cell @entity5 : research of potential markers of XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignancy']


abstract: PURPOSE: To compare outcomes of prosthetic arthroplasty versus arthrodesis to treat index finger proximal interphalangeal (PIP) joint @entity625 . METHODS: @entity1 with @entity571 or @entity625 of index finger PIP joints were evaluated. Digit range of motion, grip and pinch strength, @entity1 -rated @entity158 and satisfaction scores, Michigan Hand Questionnaire scores, and complications were recorded. RESULTS: A total of 79 finger PIP joints were followed for a median of 67 months overall (72 mo for arthroplasty and 8 mo for the arthrodesis group). Sixty-five were treated with arthroplasty and 14 with arthrodesis. @entity1 undergoing arthroplasty experienced no significant postoperative change in PIP joint range of motion whereas all preoperative @entity6520 was eliminated after arthrodesis. @entity1 undergoing arthroplasty experienced significant postoperative improvement in opposition pinch. In contrast, @entity1 undergoing arthrodesis experienced significant improvement in both opposition and apposition pinch. There were no differences in @entity158 relief, satisfaction, or Michigan Hand Questionnaire scores between treatment groups. @entity1 undergoing arthroplasty had a significantly greater mean number of complications per year and mean number of complications in the first year postoperatively. There was a 4.3 times increased risk of complication in @entity1 undergoing arthroplasty versus arthrodesis, and Kaplan-Meier analysis revealed a shorter time to first complication among @entity1 undergoing arthroplasty. CONCLUSIONS: The decision for prosthetic arthroplasty versus arthrodesis in the index finger of @entity1 with @entity571 or @entity625 must be made with @entity1 goals in mind and in light of greater risk of complications associated with arthroplasty. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic III.

title: Prosthetic Arthroplasty Versus Arthrodesis for @entity571 and XXXX of the Index Finger Proximal Interphalangeal Joint.

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis', 'posttraumatic arthritis']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity6520 :: ('MESH:C536223', 'Disease') :: ['PIP joint motion']

answer: @entity625 :: (MESH:D001168,Disease) :: ['Posttraumatic Arthritis']


abstract: PURPOSE: To compare outcomes of prosthetic arthroplasty versus arthrodesis to treat index finger proximal interphalangeal (PIP) joint @entity625 . METHODS: @entity1 with @entity571 or @entity625 of index finger PIP joints were evaluated. Digit range of motion, grip and pinch strength, @entity1 -rated @entity158 and satisfaction scores, Michigan Hand Questionnaire scores, and complications were recorded. RESULTS: A total of 79 finger PIP joints were followed for a median of 67 months overall (72 mo for arthroplasty and 8 mo for the arthrodesis group). Sixty-five were treated with arthroplasty and 14 with arthrodesis. @entity1 undergoing arthroplasty experienced no significant postoperative change in PIP joint range of motion whereas all preoperative @entity6520 was eliminated after arthrodesis. @entity1 undergoing arthroplasty experienced significant postoperative improvement in opposition pinch. In contrast, @entity1 undergoing arthrodesis experienced significant improvement in both opposition and apposition pinch. There were no differences in @entity158 relief, satisfaction, or Michigan Hand Questionnaire scores between treatment groups. @entity1 undergoing arthroplasty had a significantly greater mean number of complications per year and mean number of complications in the first year postoperatively. There was a 4.3 times increased risk of complication in @entity1 undergoing arthroplasty versus arthrodesis, and Kaplan-Meier analysis revealed a shorter time to first complication among @entity1 undergoing arthroplasty. CONCLUSIONS: The decision for prosthetic arthroplasty versus arthrodesis in the index finger of @entity1 with @entity571 or @entity625 must be made with @entity1 goals in mind and in light of greater risk of complications associated with arthroplasty. TYPE OF STUDY/LEVEL OF EVIDENCE: Therapeutic III.

title: Prosthetic Arthroplasty Versus Arthrodesis for XXXX and @entity625 of the Index Finger Proximal Interphalangeal Joint.

answer: @entity571 :: (MESH:D010003,Disease) :: ['Osteoarthritis']


abstract: Recent evidence indicates that the vasculature contains mesenchymal stem cells (MSCs). We hypothesized that @entity2178 ( @entity2178 ) type 2 receptors (AT2Rs) play a role in the osteogenesis of MSCs and may have a role in @entity729 . @entity1 MSCs were differentiated into osteoblasts. Expression of AT2R was significantly increased during osteogenesis, whereas the expression of @entity2178 type 1 receptors was not significantly changed. Incubation with the AT2R blocker @entity11083 with or without @entity2178 significantly inhibited @entity460 deposition, whereas type 1 receptor blocker @entity917 had no significant effect. @entity11083 inhibited @entity3963 ( @entity3963 ) phosphorylation in the osteogenic process, whereas @entity917 had no effect. Furthermore, @entity11083 combined with @entity2178 also inhibited acute @entity3963 phosphorylation in MSCs induced by insulin. In conclusion, AT2R is upregulated during osteogenesis. Blockade of AT2R inhibits osteogenesis and @entity3963 phosphorylation of @entity1 MSCs. These results provide a novel insight into the pathophysiology of @entity729 .

title: Blockade of angiotensin II type 2 receptor by XXXX inhibits osteogenic differentiation of @entity1 mesenchymal stem cells via inhibition of @entity3963 signaling.

entities_list: @entity917 :: ('MESH:C081489', 'Chemical') :: ['valsartan']

entities_list: @entity2178 :: ('183', 'Gene') :: ['angiotensin II', 'Ang II']

entities_list: @entity3963 :: ('5594', 'Gene') :: ['extracellular signal-regulated kinase', 'ERK']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['vascular calcification', 'calcific vascular disease']

answer: @entity11083 :: (MESH:C073402,Chemical) :: ['PD123319']


abstract: Recent evidence indicates that the vasculature contains mesenchymal stem cells (MSCs). We hypothesized that @entity2178 ( @entity2178 ) type 2 receptors (AT2Rs) play a role in the osteogenesis of MSCs and may have a role in @entity729 . @entity1 MSCs were differentiated into osteoblasts. Expression of AT2R was significantly increased during osteogenesis, whereas the expression of @entity2178 type 1 receptors was not significantly changed. Incubation with the AT2R blocker @entity11083 with or without @entity2178 significantly inhibited @entity460 deposition, whereas type 1 receptor blocker @entity917 had no significant effect. @entity11083 inhibited @entity3963 ( @entity3963 ) phosphorylation in the osteogenic process, whereas @entity917 had no effect. Furthermore, @entity11083 combined with @entity2178 also inhibited acute @entity3963 phosphorylation in MSCs induced by insulin. In conclusion, AT2R is upregulated during osteogenesis. Blockade of AT2R inhibits osteogenesis and @entity3963 phosphorylation of @entity1 MSCs. These results provide a novel insight into the pathophysiology of @entity729 .

title: Blockade of angiotensin II type 2 receptor by @entity11083 inhibits osteogenic differentiation of @entity1 mesenchymal stem cells via inhibition of XXXX signaling.

answer: @entity3963 :: (5594,Gene) :: ['extracellular signal-regulated kinase']


abstract: Recent evidence indicates that the vasculature contains mesenchymal stem cells (MSCs). We hypothesized that @entity2178 ( @entity2178 ) type 2 receptors (AT2Rs) play a role in the osteogenesis of MSCs and may have a role in @entity729 . @entity1 MSCs were differentiated into osteoblasts. Expression of AT2R was significantly increased during osteogenesis, whereas the expression of @entity2178 type 1 receptors was not significantly changed. Incubation with the AT2R blocker @entity11083 with or without @entity2178 significantly inhibited @entity460 deposition, whereas type 1 receptor blocker @entity917 had no significant effect. @entity11083 inhibited @entity3963 ( @entity3963 ) phosphorylation in the osteogenic process, whereas @entity917 had no effect. Furthermore, @entity11083 combined with @entity2178 also inhibited acute @entity3963 phosphorylation in MSCs induced by insulin. In conclusion, AT2R is upregulated during osteogenesis. Blockade of AT2R inhibits osteogenesis and @entity3963 phosphorylation of @entity1 MSCs. These results provide a novel insight into the pathophysiology of @entity729 .

title: Blockade of angiotensin II type 2 receptor by @entity11083 inhibits osteogenic differentiation of XXXX mesenchymal stem cells via inhibition of @entity3963 signaling.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: Recent evidence suggests that the insular cortex may play an important role in cognitive and emotional processes that facilitate drug use but it is unclear whether changes to the insula would result in sustained abstinence. To better understand the role of the insula in maintaining abstinence, we examined quitting patterns in smokers with acute damage to their insula relative to other regions. DESIGN: Prospective cohort study with 3month follow-up, beginning June 2013 and ending May 2014. SETTING: Three acute care hospitals in Rochester, NY. @entity1 : One-hundred-fifty-six current smokers hospitalized for acute @entity385 ; 38 with insular @entity1188 and 118 with non-insular @entity1188 , assessed by 3 neuroradiologists. MEASUREMENTS: Self-reported smoking status (seven-day point prevalence and continuous abstinence), complete abstinence from any @entity1239 product, and disruption of smoking addiction (defined by criteria on smoking status, difficulty of quitting, and urge) were assessed at three months post- @entity64 . Time to relapse (in days) after discharge was also assessed. RESULTS: Insular damage was associated with increased odds of three-month continuous abstinence (OR=3.71, 95% CI: 1.59, 8.65) and complete cessation from any @entity1239 product (OR=2.72, 95% CI: 1.19, 6.22). Average time to relapse was longer in the insular-damaged group (17.50days, SD=19.82) relative to @entity16 (10.42days, SD=18.49). Among quitters, insular damage was also associated with higher relative odds of experiencing a disruption of addiction compared to @entity16 (adjusted OR=5.60, 95% CI: 1.52, 20.56). CONCLUSIONS: These findings support the potential role of the insular cortex in maintaining smoking and @entity1239 abstinence. Further research is needed to establish whether the insula may be a novel target for smoking cessation interventions.

title: Smoking cessation behaviors three months following acute insular damage from XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['non-insular damage']

entities_list: @entity1239 :: ('MESH:D009538', 'Chemical') :: ['nicotine']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: The @entity1 Tribbles (TRB)-related pseudokinases are CAMK ( @entity460 /calmodulin-dependent protein kinase)-related family members that have evolved a series of highly unusual motifs in the 'pseudocatalytic' domain. In canonical kinases, conserved @entity3534 bind to divalent metal ions and align @entity855 prior to efficient @entity11064 -transfer to substrates. However, in pseudokinases, atypical residues give rise to diverse and often unstudied biochemical and structural features that are thought to be central to cellular functions. TRB proteins play a crucial role in multiple signalling networks and overexpression confers @entity5 phenotypes on @entity1 cells, marking TRB pseudokinases out as a novel class of drug target. In the present paper, we report that the @entity1 pseudokinase @entity71414 retains the ability to both bind and hydrolyse @entity855 weakly in  vitro. Kinase activity is metal-independent and involves a catalytic @entity376 residue, which is conserved in TRB proteins throughout evolution alongside several unique @entity3534 in the active site. A similar low level of autophosphorylation is also preserved in the closely related @entity1 @entity18410 . By employing chemical genetics, we establish that the @entity4334 -binding site of an 'analogue-sensitive' (AS) @entity71414 mutant can be targeted with specific bulky ligands of the @entity33378 (PP) chemotype. Our analysis confirms that @entity71414 retains low levels of @entity855 binding and/or catalysis that is targetable with small molecules. Given the significant clinical successes associated with targeting of @entity5 -associated kinases with small molecule inhibitors, it is likely that similar approaches will be useful for further evaluating the TRB pseudokinases, with the translation of this information likely to furnish new leads for drug discovery.

title: The XXXX ( @entity71414 ) pseudokinase binds to @entity855 and autophosphorylates in a metal-independent manner.

entities_list: @entity3534 :: ('MESH:D000596', 'Chemical') :: ['amino acids']

entities_list: @entity33378 :: ('CHEBI:38669', 'Chemical') :: ['pyrazolo-pyrimidine']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

entities_list: @entity11064 :: ('CHEBI:29315', 'Chemical') :: ['phosphoryl']

answer: @entity71414 :: (28951,Gene) :: ['Tribbles 2']


abstract: The @entity1 Tribbles (TRB)-related pseudokinases are CAMK ( @entity460 /calmodulin-dependent protein kinase)-related family members that have evolved a series of highly unusual motifs in the 'pseudocatalytic' domain. In canonical kinases, conserved @entity3534 bind to divalent metal ions and align @entity855 prior to efficient @entity11064 -transfer to substrates. However, in pseudokinases, atypical residues give rise to diverse and often unstudied biochemical and structural features that are thought to be central to cellular functions. TRB proteins play a crucial role in multiple signalling networks and overexpression confers @entity5 phenotypes on @entity1 cells, marking TRB pseudokinases out as a novel class of drug target. In the present paper, we report that the @entity1 pseudokinase @entity71414 retains the ability to both bind and hydrolyse @entity855 weakly in  vitro. Kinase activity is metal-independent and involves a catalytic @entity376 residue, which is conserved in TRB proteins throughout evolution alongside several unique @entity3534 in the active site. A similar low level of autophosphorylation is also preserved in the closely related @entity1 @entity18410 . By employing chemical genetics, we establish that the @entity4334 -binding site of an 'analogue-sensitive' (AS) @entity71414 mutant can be targeted with specific bulky ligands of the @entity33378 (PP) chemotype. Our analysis confirms that @entity71414 retains low levels of @entity855 binding and/or catalysis that is targetable with small molecules. Given the significant clinical successes associated with targeting of @entity5 -associated kinases with small molecule inhibitors, it is likely that similar approaches will be useful for further evaluating the TRB pseudokinases, with the translation of this information likely to furnish new leads for drug discovery.

title: The @entity71414 ( XXXX ) pseudokinase binds to @entity855 and autophosphorylates in a metal-independent manner.

answer: @entity71414 :: (28951,Gene) :: ['TRB2']


abstract: The @entity1 Tribbles (TRB)-related pseudokinases are CAMK ( @entity460 /calmodulin-dependent protein kinase)-related family members that have evolved a series of highly unusual motifs in the 'pseudocatalytic' domain. In canonical kinases, conserved @entity3534 bind to divalent metal ions and align @entity855 prior to efficient @entity11064 -transfer to substrates. However, in pseudokinases, atypical residues give rise to diverse and often unstudied biochemical and structural features that are thought to be central to cellular functions. TRB proteins play a crucial role in multiple signalling networks and overexpression confers @entity5 phenotypes on @entity1 cells, marking TRB pseudokinases out as a novel class of drug target. In the present paper, we report that the @entity1 pseudokinase @entity71414 retains the ability to both bind and hydrolyse @entity855 weakly in  vitro. Kinase activity is metal-independent and involves a catalytic @entity376 residue, which is conserved in TRB proteins throughout evolution alongside several unique @entity3534 in the active site. A similar low level of autophosphorylation is also preserved in the closely related @entity1 @entity18410 . By employing chemical genetics, we establish that the @entity4334 -binding site of an 'analogue-sensitive' (AS) @entity71414 mutant can be targeted with specific bulky ligands of the @entity33378 (PP) chemotype. Our analysis confirms that @entity71414 retains low levels of @entity855 binding and/or catalysis that is targetable with small molecules. Given the significant clinical successes associated with targeting of @entity5 -associated kinases with small molecule inhibitors, it is likely that similar approaches will be useful for further evaluating the TRB pseudokinases, with the translation of this information likely to furnish new leads for drug discovery.

title: The @entity71414 ( @entity71414 ) pseudokinase binds to XXXX and autophosphorylates in a metal-independent manner.

answer: @entity855 :: (MESH:D000255,Chemical) :: ['ATP']


abstract: OBJECTIVES: To evaluate @entity7441 ( @entity7441 ) as a prognostic tool after resection of @entity463 . METHODS: Sixty @entity7441 examinations were evaluated for perioperative @entity1188 , @entity5 growth between diagnosis and @entity7441 , contrast enhancement pattern, and extent of resection (EOR). The EOR was approached with the subjective evaluation of radiologists and by quantifying volumes. These parameters were tested as predictors of survival using the Kaplan-Meier method. RESULTS: Contrast enhancement was found in 59 @entity1 (59/60; 98  %). Showing a thin-linear pattern of enhancement was the most favourable finding. @entity1 with this pattern survived longer than @entity1 with thick-linear (median overall survival (OS) thin-linear=609  days; thick-linear=432  days; P   =   .023) or nodular (median OS   =   318  days; P   =   .001) enhancements. The subjective evaluation of the EOR performed better than its quantification. @entity1 survived longer when resection was total (median OS total resection=609  days; subtotal=371  days; P   =   .001). When resection was subtotal, @entity1 survived longer if it was superior to 95  % (median OS resection superior to 95  %=559  days; inferior to 95  %=256  days; P   =   .034). CONCLUSIONS: @entity7441 provides valuable prognostic information after surgical resection of @entity463 . A thin-linear pattern of contrast enhancement is the most favourable finding. Further prognostic stratification may be obtained by assessing the EOR. KEY POINTS:     Some kind of contrast enhancement may be found in most @entity7441 examinations.     Thin-linear enhancements in the @entity7441 may be considered benign findings.     The EOR evaluated in the @entity7441 may stratify prognostic groups of @entity1 .     The subjective evaluation of the EOR performs slightly better than its quantification.

title: Early post-operative magnetic resonance imaging in XXXX : correlation among radiological findings and overall survival in 60 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity7441 :: ('MESH:D056987', 'Disease') :: ['early post-operative magnetic resonance', 'EPMR']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastomas', 'glioblastoma']

answer: @entity463 :: (MESH:D005909,Disease) :: ['glioblastoma']


abstract: OBJECTIVES: To evaluate @entity7441 ( @entity7441 ) as a prognostic tool after resection of @entity463 . METHODS: Sixty @entity7441 examinations were evaluated for perioperative @entity1188 , @entity5 growth between diagnosis and @entity7441 , contrast enhancement pattern, and extent of resection (EOR). The EOR was approached with the subjective evaluation of radiologists and by quantifying volumes. These parameters were tested as predictors of survival using the Kaplan-Meier method. RESULTS: Contrast enhancement was found in 59 @entity1 (59/60; 98  %). Showing a thin-linear pattern of enhancement was the most favourable finding. @entity1 with this pattern survived longer than @entity1 with thick-linear (median overall survival (OS) thin-linear=609  days; thick-linear=432  days; P   =   .023) or nodular (median OS   =   318  days; P   =   .001) enhancements. The subjective evaluation of the EOR performed better than its quantification. @entity1 survived longer when resection was total (median OS total resection=609  days; subtotal=371  days; P   =   .001). When resection was subtotal, @entity1 survived longer if it was superior to 95  % (median OS resection superior to 95  %=559  days; inferior to 95  %=256  days; P   =   .034). CONCLUSIONS: @entity7441 provides valuable prognostic information after surgical resection of @entity463 . A thin-linear pattern of contrast enhancement is the most favourable finding. Further prognostic stratification may be obtained by assessing the EOR. KEY POINTS:     Some kind of contrast enhancement may be found in most @entity7441 examinations.     Thin-linear enhancements in the @entity7441 may be considered benign findings.     The EOR evaluated in the @entity7441 may stratify prognostic groups of @entity1 .     The subjective evaluation of the EOR performs slightly better than its quantification.

title: Early post-operative magnetic resonance imaging in @entity463 : correlation among radiological findings and overall survival in 60 XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Intracellular @entity460 accumulation is associated with cell death in several @entity74 including @entity2806 , but the exact mechanisms of @entity730 need to be clarified. We used organotypic hippocampal slice culture - cultures subjected to @entity26 - @entity413 deprivation (OGD) mimicking the in vivo situation to investigate the events underlying ectopic @entity730 . @entity622 staining indicating @entity460 deposition was observed in the cornu ammonis (CA)1 and dentate gyrus regions in control hippocampal slices despite no specific labeling for cell death markers. Electron microscopy using the @entity12925 / @entity24234 method revealed scattered degenerated cells throughout the normally appearing @entity1249 region. They contained electron-dense precipitates within mitochondria, and electron probe microanalysis confirmed that they were calcifying mitochondria. Selective @entity460 deposition was noted within, but not beyond, mitochondria in these mineralized cells. They showed ultrastructural features of non-necrotic, non-apoptotic cell death and retained their compact ultrastructure, even after the majority of mitochondria were calcified. Unexpectedly, no intracellular @entity730 was noted in necrotic @entity1249 pyramidal cells after OGD, and there was no progression of @entity730 in OGD-lesioned slices. In addition, mineralized cells in both control and OGD-lesioned slices were closely associated with or completely engulfed by astrocytes but not microglia. These astrocytes were laden with heterogeneous cytoplasmic inclusions that appeared to be related with their phagocytic activity. These data demonstrate that microcalcification specifically associated with mitochondria might lead to a novel type of cell death and suggest that astrocytes may be involved in the phagocytosis of these mineralized cells and possibly in the regulation of ectopic @entity730 .

title: Ultrastructural investigation of microcalcification and the role of XXXX - @entity413 deprivation in cultured rat hippocampal slices.

entities_list: @entity24234 :: ('MESH:D011192', 'Chemical') :: ['potassium dichromate']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['brain ischemia']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity622 :: ('MESH:C010078', 'Chemical') :: ['Alizarin red']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['neuropathological disorders']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: UNASSIGNED: Intracellular @entity460 accumulation is associated with cell death in several @entity74 including @entity2806 , but the exact mechanisms of @entity730 need to be clarified. We used organotypic hippocampal slice culture - cultures subjected to @entity26 - @entity413 deprivation (OGD) mimicking the in vivo situation to investigate the events underlying ectopic @entity730 . @entity622 staining indicating @entity460 deposition was observed in the cornu ammonis (CA)1 and dentate gyrus regions in control hippocampal slices despite no specific labeling for cell death markers. Electron microscopy using the @entity12925 / @entity24234 method revealed scattered degenerated cells throughout the normally appearing @entity1249 region. They contained electron-dense precipitates within mitochondria, and electron probe microanalysis confirmed that they were calcifying mitochondria. Selective @entity460 deposition was noted within, but not beyond, mitochondria in these mineralized cells. They showed ultrastructural features of non-necrotic, non-apoptotic cell death and retained their compact ultrastructure, even after the majority of mitochondria were calcified. Unexpectedly, no intracellular @entity730 was noted in necrotic @entity1249 pyramidal cells after OGD, and there was no progression of @entity730 in OGD-lesioned slices. In addition, mineralized cells in both control and OGD-lesioned slices were closely associated with or completely engulfed by astrocytes but not microglia. These astrocytes were laden with heterogeneous cytoplasmic inclusions that appeared to be related with their phagocytic activity. These data demonstrate that microcalcification specifically associated with mitochondria might lead to a novel type of cell death and suggest that astrocytes may be involved in the phagocytosis of these mineralized cells and possibly in the regulation of ectopic @entity730 .

title: Ultrastructural investigation of microcalcification and the role of @entity26 - XXXX deprivation in cultured rat hippocampal slices.

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: BACKGROUND: The pharmacological prevention of @entity1211 ( @entity1211 ) has so far been carried out mainly with classic (low-molecular-weight heparins, coumarins) or new direct oral anticoagulants (DOACs). The role of antiplatelet treatment with aspirin is controversial. New data, however, suggest a paradigm shift with the reassessment of aspirin as part of a multimodal antithrombotic approach. OBJECTIVE: The article provides an up-to-date overview of the role of antiplatelet treatment with aspirin in the primary and secondary prevention of @entity1211 . CURRENT DATA AND RESULTS: Primary prevention of surgery-related @entity1211 with anticoagulants is effective but apparently not superior to a multimodal approach with aspirin, pneumatic compression, and early mobilization. Against this background, aspirin is now also included in the @entity1211 prevention guidelines in the US (ACCP, AAOS) but not in the UK (NICE) and Germany (AMWF). A final evaluation of aspirin as compared to classic anticoagulants and DOACs in primary prophylaxis requires further randomized controlled, prospective trials. These should also consider the iatrogenic risk of @entity548 as well as possible @entity260 , such as retarded wound healing that might require prolonged hospitalization. After ending guideline-conforming anticoagulant treatment in @entity1 with idiopathic @entity1211 , administration of aspirin reduces the risk of recurrent @entity1211 by about 40   % without increasing the risk of severe @entity548 (standardized INSPIRE evaluation of ASPIRE and WARFASA data). These data add to the current use of aspirin in the prevention of arterial @entity715 the new option of preventing spontaneous @entity1211 . CONCLUSION: On the basis of new data from recent studies, an indication can be made for the use of aspirin, combined with other preventive measures, in the prevention of primary and secondary @entity1150 .

title: [Aspirin and XXXX .]

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['venous thromboses']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['venous thromboses']


abstract: OBJECTIVES: Iliac branch grafts (IBGs) are a validated option for the treatment of @entity1029 preserving @entity2998 ( @entity2998 ) flow. @entity2998 @entity439 (IIAA) is a relative contraindication to IBG placement. The goal of this study was to review experience in managing @entity1029 with concomitant IIAAs with extension of the @entity2998 branch stent graft into the superior gluteal artery (SGA). METHODS: This retrospective study between May 2009 and November 2014 includes consecutive @entity1 who underwent placement of an IBG (Cook, Bloomington, IN, USA) with extension of the internal iliac component of the branch stent graft into the SGA because of @entity1029 (>15  mm). The stent grafts used were Viabahn (Gore, Karlsruhe, Germany), Fluency (Bard, Flagstaff, AZ, USA), or iCast (Atrium, Hudson, NH, USA) proximally. Imaging follow up was with computed tomography angiography (CTA) within 30 days of device insertion and then annually. RESULTS: The procedure was performed on 15 @entity1 with a mean age of 76.8 years (SD 6.1 years). Twenty IIAAs were treated with a mean @entity2998 and common iliac artery (CIA) diameter of 33  mm (SD 13  mm) and 35  mm (SD 11  mm) respectively. Technical success rate was 100%. One @entity1 who underwent simultaneous IBG and three vessel fenestrated @entity439 repair died of @entity5327 2 days after the procedure. Mean imaging follow up with CTA was 18.3 months (SD 15.1 months). Primary patency of the SGA stent grafts was 100%. There was one case of @entity1070 . All @entity1 were free from buttock claudication at follow up (mean: 19.7 months). Two @entity1 who had @entity2998 embolization contralateral to the IBG placement suffered from unilateral lower limb monoparesis. CONCLUSIONS: Extension of the internal iliac component of IBGs into the SGA for distal seal is feasible and safe in the endovascular treatment of @entity1029 with concomitant IIAs. Long-term results are needed to further validate this technique.

title: XXXX Repair Outcomes Using a Modification of the Iliac Branch Graft.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1070 :: ('MESH:D057867', 'Disease') :: ['type II endoleak']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['internal iliac artery', 'IIA']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['endovascular aneurysm', 'aneurysm']

entities_list: @entity1029 :: ('MESH:D017543', 'Disease') :: ['aneurysmal IIA', 'aorto-iliac aneurysms']

entities_list: @entity5327 :: ('MESH:D065666', 'Disease') :: ['mesenteric ischemia']

answer: @entity1029 :: (MESH:D017543,Disease) :: ['Internal Iliac Aneurysm']


abstract: BACKGROUND: The objective of this study was to analyze the percentage as well as clinical and laboratory characteristics of @entity9144 ( @entity9144 ) in @entity1 admitted with @entity1897 . Additionally, we looked for diagnostic criteria to distinguish @entity4401 from @entity3541 due to @entity9144 . METHODS: Data collection was done retrospectively from 2007 until 2012. We identified 278 consecutive @entity1 , who were admitted to the department of Neurology due to @entity1897 . @entity1 were routinely investigated for @entity9144 including clinical neurological examination and cerebral spinal fluid (CSF) analysis. Demographic and clinical data were analyzed according to a standardized protocol. RESULTS: In 19 (male (m)  =  14/female (f)  =  5) out of 278 @entity1 (7  %), a diagnosis of @entity9144 was established. There were 8 @entity1 (3  %) identified with varicella zoster ( @entity7794 ) (m  =  7/f  =  1) and 13 @entity1 (5  %) with @entity3541 due to @entity6 (m  =  5/f  =  8). A total of 207 @entity1 (75  %) were diagnosed as @entity4401 (m  =  110/f  =  97). Compared with CSF of @entity1 with @entity3541 due to @entity7794 and @entity6 , @entity1 with @entity9144 showed higher cell count, protein and @entity880 levels, whereas @entity1 with @entity3541 due to @entity6 showed higher @entity413 level. With respect to seasonal clustering, an accumulation of 74  % of the @entity9144 cases was detected from June to October, whereas in the rest of the year there were only 26  % of the @entity9144 cases. @entity1 with @entity4401 are more evenly distributed over the year. Regarding neurological signs and symptoms, radicular symptoms were only reported in the @entity9144 group. Despite radicular symptoms for @entity9144 , no specific signs or symptoms were found for @entity3541 due to @entity7794 , @entity4401 , or @entity6 . CONCLUSIONS: According to the results of our study, we recommend CSF testing in any case for @entity1 with @entity3541 in an endemic area from June to October especially if additional radicular symptoms are present. To establish recommendations for a diagnostic workup in @entity1 with @entity3541 in areas endemic for @entity12732 , the seasonal clustering of @entity9144 as well as specific clinical features should also be confirmed in a future prospective trial.

title: @entity1897 as an initial symptom of XXXX in an Austrian endemic area.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity9144 :: ('MESH:D020852', 'Disease') :: ['Lyme neuroborreliosis', 'LNB']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic mononeuropathy']

entities_list: @entity4401 :: ('MESH:D020330', 'Disease') :: ["Bell's palsy"]

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral facial palsy']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial palsy']

answer: @entity9144 :: (MESH:D020852,Disease) :: ['Lyme neuroborreliosis']


abstract: BACKGROUND: The objective of this study was to analyze the percentage as well as clinical and laboratory characteristics of @entity9144 ( @entity9144 ) in @entity1 admitted with @entity1897 . Additionally, we looked for diagnostic criteria to distinguish @entity4401 from @entity3541 due to @entity9144 . METHODS: Data collection was done retrospectively from 2007 until 2012. We identified 278 consecutive @entity1 , who were admitted to the department of Neurology due to @entity1897 . @entity1 were routinely investigated for @entity9144 including clinical neurological examination and cerebral spinal fluid (CSF) analysis. Demographic and clinical data were analyzed according to a standardized protocol. RESULTS: In 19 (male (m)  =  14/female (f)  =  5) out of 278 @entity1 (7  %), a diagnosis of @entity9144 was established. There were 8 @entity1 (3  %) identified with varicella zoster ( @entity7794 ) (m  =  7/f  =  1) and 13 @entity1 (5  %) with @entity3541 due to @entity6 (m  =  5/f  =  8). A total of 207 @entity1 (75  %) were diagnosed as @entity4401 (m  =  110/f  =  97). Compared with CSF of @entity1 with @entity3541 due to @entity7794 and @entity6 , @entity1 with @entity9144 showed higher cell count, protein and @entity880 levels, whereas @entity1 with @entity3541 due to @entity6 showed higher @entity413 level. With respect to seasonal clustering, an accumulation of 74  % of the @entity9144 cases was detected from June to October, whereas in the rest of the year there were only 26  % of the @entity9144 cases. @entity1 with @entity4401 are more evenly distributed over the year. Regarding neurological signs and symptoms, radicular symptoms were only reported in the @entity9144 group. Despite radicular symptoms for @entity9144 , no specific signs or symptoms were found for @entity3541 due to @entity7794 , @entity4401 , or @entity6 . CONCLUSIONS: According to the results of our study, we recommend CSF testing in any case for @entity1 with @entity3541 in an endemic area from June to October especially if additional radicular symptoms are present. To establish recommendations for a diagnostic workup in @entity1 with @entity3541 in areas endemic for @entity12732 , the seasonal clustering of @entity9144 as well as specific clinical features should also be confirmed in a future prospective trial.

title: XXXX as an initial symptom of @entity9144 in an Austrian endemic area.

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1897 :: (MESH:D010523,Disease) :: ['Peripheral facial palsy']


abstract: OBJECTIVE: There is an increased interest in developing gene therapy approaches for local delivery of therapeutic genes in @entity1 with @entity625 . Intra-articular (i.a.) gene delivery, using an adeno-associated virus encoding a @entity310 soluble receptor, resulted in reduced paw swelling in an @entity625 animal model, but i.a. treatment with a similar vector did not induce robust clinical improvement in @entity1 . It is unclear whether this can be explained by for instance insufficient transduction efficiency or the fact that @entity310 is not a good therapeutic target for i.a treatment. The objective of this study was to explore the effects of i.a @entity310 blockade. METHODS: Thirty-one @entity1 with @entity309 or @entity5144 were assigned to a single i.a. injection of 25mg etanercept or placebo in a double-blind randomised controlled clinical trial. The primary end point was target joint improvement, determined by a composite change index. RESULTS: Twenty-two @entity1 received etanercept and 9 received placebo. Treatment was generally well tolerated. Treatment with etanercept resulted in a prompt and statistically significant improvement of the index (P<0.001) in comparison with placebo. As expected in light of the half-life of etanercept, the beneficial effect was transient and only statistically significant at week 1 and 2 after i.a. injection. CONCLUSION: The results support the development of novel approaches for long-term inhibition of @entity310 at the site of @entity32 , such as gene therapy. TRIAL REGISTRATION: The Netherlands National Trial Register (NTR), www.trialregister.nl, NTR-1210.

title: Intra-articular etanercept treatment in @entity625 : A randomized double-blind placebo-controlled proof of mechanism clinical trial validating XXXX as a potential therapeutic target for local treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic arthritis']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid']

answer: @entity310 :: (7124,Gene) :: ['TNF']


abstract: OBJECTIVE: There is an increased interest in developing gene therapy approaches for local delivery of therapeutic genes in @entity1 with @entity625 . Intra-articular (i.a.) gene delivery, using an adeno-associated virus encoding a @entity310 soluble receptor, resulted in reduced paw swelling in an @entity625 animal model, but i.a. treatment with a similar vector did not induce robust clinical improvement in @entity1 . It is unclear whether this can be explained by for instance insufficient transduction efficiency or the fact that @entity310 is not a good therapeutic target for i.a treatment. The objective of this study was to explore the effects of i.a @entity310 blockade. METHODS: Thirty-one @entity1 with @entity309 or @entity5144 were assigned to a single i.a. injection of 25mg etanercept or placebo in a double-blind randomised controlled clinical trial. The primary end point was target joint improvement, determined by a composite change index. RESULTS: Twenty-two @entity1 received etanercept and 9 received placebo. Treatment was generally well tolerated. Treatment with etanercept resulted in a prompt and statistically significant improvement of the index (P<0.001) in comparison with placebo. As expected in light of the half-life of etanercept, the beneficial effect was transient and only statistically significant at week 1 and 2 after i.a. injection. CONCLUSION: The results support the development of novel approaches for long-term inhibition of @entity310 at the site of @entity32 , such as gene therapy. TRIAL REGISTRATION: The Netherlands National Trial Register (NTR), www.trialregister.nl, NTR-1210.

title: Intra-articular etanercept treatment in XXXX : A randomized double-blind placebo-controlled proof of mechanism clinical trial validating @entity310 as a potential therapeutic target for local treatment.

answer: @entity625 :: (MESH:D001168,Disease) :: ['inflammatory arthritis']