abstract: BACKGROUND: Whether @entity28 affects surgical outcomes in @entity1 with @entity157 ( @entity157 ) is controversial. Here we retrospectively evaluated the impact of @entity28 on outcomes in @entity157 @entity1 after curative hepatectomy. METHODS: @entity1 with @entity1 -Pugh A liver function who underwent curative hepatectomy between 2006 and 2010 were categorized as @entity28 (BMI >= 25 kg/m2, n = 68) and @entity28 (<25 kg/m2, n = 242). To reduce interference from baseline differences between the two groups, propensity score-matched analysis was performed in the ratio 1:2 using a caliper width of 0.1. Surgical outcomes were compared for 61 @entity28 and 115 @entity28 @entity1 . RESULTS: @entity28 @entity1 had higher levels of albumin and @entity5906 aminotransferase, and more @entity5 compared to the @entity28 @entity1 (all P<0.05). In the propensity-matched cohort, baseline characteristics did not differ between the two groups (all P>0.05). @entity28 and @entity28 @entity1 had comparable 30-day mortality (1.6% vs. 2.6%, P = 1.000), 90-day mortality (3.3% vs. 4.3%, P = 1.000), and incidence of @entity260 (19.7% vs. 18.3%, P = 0.819). Overall survival at 1, 3, and 5 years was similar for @entity28 @entity1 (83.6%, 63.6%, 41.6%) as for @entity28 @entity1 (80.9%, 65.9%, 49.1%; P = 0.358). Disease-free survival at 1, 3, and 5 years was also similar for @entity28 @entity1 (71.5%, 36.3%, 24.3%) as for @entity28 ones (60.2%, 43.7%, 27.7%; P = 0.969). CONCLUSION: Our propensity score-matched analysis strengthens the case that @entity28 does not adversely affect surgical outcomes of @entity157 @entity1 undergoing curative hepatectomy.

title: Obesity Does Not Influence Outcomes in @entity157 XXXX following Curative Hepatectomy.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: RATIONALE: Volatile organic compounds present in the exhaled breath have shown promise as biomarkers of @entity2 . Advances in colorimetric sensor array technology, breath collection methods, and clinical phenotyping may lead to the development of a more accurate breath biomarker. OBJECTIVES: Perform a discovery-level assessment of the accuracy of a colorimetric sensor array-based volatile breath biomarker. METHODS: Subjects with biopsy-confirmed untreated @entity2 , and others at risk for developing @entity2 , performed tidal breathing into a breath collection instrument designed to expose a colorimetric sensor array to the alveolar portion of the breath. Random forest models were built from the sensor output of 70% of the study subjects and were tested against the remaining 30%. Models were developed to separate @entity5 and subgroups from control, and to characterize the @entity5 . Additional models were developed after matching the clinical phenotypes of @entity5 and control subjects. MEASUREMENTS AND MAIN RESULTS: Ninety-seven subjects with @entity2 and 182 control subjects participated. The accuracies, reported @entity2031 -statistics, for models of @entity5 and subgroups versus control ranged from 0.794 to 0.861. The accuracy was improved by developing models for @entity5 and control groups selected through propensity matching for clinical variables. A model built using only subjects from the largest available clinical subgroup (49 subjects) had a C-statistic of 0.982. Models developed and tested to characterize @entity5 histology, and to compare early- with late-stage @entity5 , had C-statistics of 0.881-0.960. CONCLUSIONS: The colorimetric sensor array signature of exhaled breath volatile organic compounds was capable of distinguishing @entity1 with @entity2 from clinically relevant control subjects in a discovery level trial. The incorporation of clinical phenotypes into the further development of this biomarker may optimize its accuracy.

title: Progress in the Development of Volatile Exhaled Breath Signatures of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

answer: @entity2 :: (MESH:D008175,Disease) :: ['Lung Cancer']


abstract: UNASSIGNED: Sleep and @entity302 have a close relationship. About 20% of @entity1 suffer @entity410 only during the night, approximately 40% only during the day and approximately 35% during the day and night. In @entity302 , the occurrence of @entity410 is strongly related to sleep or awakening. Infantile @entity2473 appear predominately on awakening, and @entity739 is sometimes visible only in sleep. @entity1 with @entity751 or @entity302 with @entity1654 (BECTS) have @entity410 mostly when asleep, and in both syndromes interictal spike waves are markedly accentuated in slow wave sleep. Electrical @entity159 during slow sleep/continuous spike wave discharges during sleep (ESES/CSWS), atypical benign partial @entity302 , and @entity12924 are @entity302 with substantial behavioral and @entity73 , @entity410 , and continuous spike-wave activity during non-rapid eye movement (NREM) sleep. The hallmark of juvenile @entity3148 and grand mal @entity410 on awakening are @entity410 symptoms within 2 hours after awakening, often provoked by @entity1949 . @entity4940 is sometimes mistaken for @entity4939 . Differentiation is possible when the clinical symptoms and the frequency of the paroxysmal events per night and month are carefully observed and nocturnal video electroencephalography (EEG) performed. Sleep EEG recordings may be helpful in @entity1 with suspected @entity302 and nonconclusive awake EEG. Depending on the clinical question, sleep recordings should be performed during nap (natural sleep or drug induced), during the night, or after @entity1949 .

title: Sleep and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Children']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'various seizures']

entities_list: @entity1949 :: ('MESH:D012892', 'Disease') :: ['sleep deprivation']

entities_list: @entity12924 :: ('MESH:D018887', 'Disease') :: ['Landau-Kleffner syndrome']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits']

entities_list: @entity739 :: ('MESH:D013036', 'Disease') :: ['hypsarrhythmia']

entities_list: @entity4939 :: ('MESH:D020447', 'Disease') :: ['parasomnia']

entities_list: @entity1654 :: ('MESH:D019305', 'Disease') :: ['centrotemporal spikes']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['certain epilepsy syndromes', 'epilepsy', 'epileptic encephalopathies', 'benign epilepsy']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['Panayiotopoulos syndrome']

entities_list: @entity3148 :: ('MESH:D004831', 'Disease') :: ['myoclonic epilepsy']

entities_list: @entity4940 :: ('MESH:D017034', 'Disease') :: ['Nocturnal frontal lobe epilepsy']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']

answer: @entity302 :: (MESH:D004827,Disease) :: ['Epilepsy Syndromes']


abstract: OBJECTIVES/HYPOTHESIS: Functional and @entity85 are common after nasal injuries and at times necessitate advanced surgery to reverse the effects of @entity130 . This study was designed to study the factors related to @entity130 and @entity1 parameters in influencing the acute management of nasal injuries and its outcome. STUDY DESIGN: Prospective study. METHODS: Nasal injuries from County Waterford in Southeast Ireland were referred to a new Cost-Neutral Nasal Fracture Clinic. The first 400 @entity1 from this prospective audit, referred to Waterford Regional Hospital from August 2009 through December 2010, were included in this study. Twenty-one variables, including satisfaction scores using Visual Analog Scale (VAS), were studied. Data was obtained at each stage of management, from initial assessment in ears, nose, and throat (ENT) casualty to being seen and further reviewed in consultant-based specialty clinic. RESULTS: @entity1 outnumbered @entity1 72: 28, and the mean age was 26.89 (0.4 years-87 years). @entity1 presenting time to the ENT casualty after the injury ranged between 1 and 90 days (mean 10.5 days). The interval between injury and intervention was on an average 6.1 days. Accident (41%) and soccer (46%), among the sports group, were predominantly related to @entity130 . The overall satisfaction rate was 77.5% for breathing and 85.6% for cosmesis. One hundred twenty-seven (31.8%) @entity1 were referred to and managed from the septorhinoplasty clinic. Overall, 11% required septorhinoplasty. @entity1 satisfaction was seen in manipulation performed up to 5 weeks postinjury. CONCLUSION: Our databank is the largest prospectively studied series of nasal-fracture management from Ireland. The incidence of @entity174 in the southeast of Ireland is 0.37%. Age, gender, mode of injury, and type of sport influenced the satisfaction rates in this study. This type of service may not be practical in all ENT departments, but a regional center may be an idea worth considering. LEVEL OF EVIDENCE: 2b. Laryngoscope, 2015.

title: Acute XXXX management: A prospective study and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'Men', 'Patient']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['cosmetic deformities']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['nasal fracture']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['nasal injury', 'trauma']

answer: @entity174 :: (MESH:D050723,Disease) :: ['nasal fracture']


abstract: Three fractions extracted from Brucella possessing immunogenic activity were tested either as unique antigens or in combinations using various dose levels. Immunity in the @entity19 was tested one month after vaccination by the intraperitoneal administration of a virulent strain of @entity6469 and the spleen count of Brucella 15 days after challenge. The brucellin protein fraction, the @entity56 reagent did not immunize the @entity19 and did not interfere with the immunization produced by the PG (cell wall PG extracted with @entity214 ) and @entity558 fractions. The PG fractions, extracted either from @entity6469 (PG-F8) or from @entity6467 (PG-F7), conferred good dose-dependent immunity used on their own. The @entity558 fraction ( @entity6467 ) on its own also conferred good immunity but the dose-response curve was less regular. Immunity induced by either fraction was not affected by the presence of an oil adjuvant. Various dose-ratio combinations of PG and @entity558 were studied with respect to their interactions in three successive factorial experiments. The interactions were consistently significant and largely negative. According to the dose of each fraction and the ratio, the immunity was either equivalent to that produced by the most active fraction in the combination (no additive effect) or less (antagonism). The antagonism between two vaccinal fractions extracted from the same bacteria pleads in favour of purified vaccines.

title: Antagonism between two immunogens extracted from Brucella (cell wall peptidoglycan and lipopolysaccharide fractions) and inactivity of the brucellin allergen in immunization of the XXXX .

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['cutaneous hypersensitivity']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: UNASSIGNED: Heparins are broadly used for the prevention and treatment of @entity715 and @entity887 . Yet, @entity170 is considered to be a severe side effect in up to one third of all @entity1 on long-term treatment. However, the mechanisms underlying this clinical problem are only partially understood. To investigate if heparin affects differentiation of skeletal precursors, we examined the effects of heparin on the osteogenic and adipogenic lineage commitment and differentiation of primary @entity1 bone marrow stromal cells (hBMSCs). Due to the known inverse relationship between adipogenesis and osteogenesis and the capacity of pre-differentiated cells to convert into the respective other lineage, we also determined heparin effects on osteogenic conversion and adipogenic differentiation/conversion. Interestingly, heparin did not only significantly increase mRNA expression and enzyme activity of the osteogenic marker @entity623 ( @entity623 ), but it also promoted mineralization during osteogenic differentiation and conversion. Furthermore, the mRNA expression of the osteogenic marker @entity13062 ( @entity13062 ) was enhanced. In addition, heparin administration partly prevented adipogenic differentiation and conversion demonstrated by reduced lipid droplet formation along with a decreased expression of adipogenic markers. Moreover, luciferase reporter assays, inhibitor experiments and gene expression analyses revealed that heparin had putative permissive effects on osteogenic signaling via the @entity6861 pathway and reduced the mRNA expression of the Wnt pathway inhibitors @entity5741 ( @entity5741 ) and sclerostin ( @entity14539 ). Taken together, our data show a rather supportive than inhibitory effect of heparin on osteogenic hBMSC differentiation and conversion in vitro. Further studies will have to investigate the net effects of heparin administration on bone formation versus bone resorption in vivo to unravel the molecular mechanisms of heparin-associated @entity170 and reconcile conflicting experimental data with clinical observations.

title: Heparin affects XXXX bone marrow stromal cell fate: Promoting osteogenic and reducing adipogenic differentiation and conversion.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity13062 :: ('652', 'Gene') :: ['bone morphogenic protein 4', 'BMP4']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity623 :: ('250', 'Gene') :: ['ALP', 'alkaline phosphatase']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The series included 52 @entity1 with @entity548 stress @entity1066 of the stomach and duodenum seen at the Mayo Clinic during a 25-year period. All @entity1 underwent operation for control of @entity548 that was unresponsive to intensive medical therapy. All @entity1066 were superficial and occurred during clinically stressful circumstances. No @entity1 had a history or findings suggestive of pre-existing peptic @entity1066 or imbibation of ulcerogenic substances. Overall operative mortality was 54%, and this rate seemed to be related to multiple factors acting together; @entity1 with multiple predisposing stress factors and those requiring large transfusion volumes (greater than 17 total units) were at greatest risk of @entity204 . Fifty-two @entity1 underwent 60 operative procedures for control of @entity548 . Of the 60 procedures, 23 (38%) failed to prevent rebleeding. Of the 28 @entity1 who died, six (21%) died of @entity548 and five (18%) died of @entity548 as one of many contributing factors. Of eight different procedures performed, near-total to total gastrectomy was the single procedure that was most effective in controlling @entity548 . The authors support the selection of rapid intervention and generous extirpative surgery once intensive medical measures fail to control @entity548 .

title: The surgical management of bleeding stress XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer disease', 'ulcers']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'acute bleeding', 'massive bleeding']

answer: @entity1066 :: (MESH:D014456,Disease) :: ['ulcers']


abstract: BACKGROUND: The pathological process of left ventricular (LV) @entity1184 is associated with left atrial (LA) remodeling. This study was aimed to evaluate the prognostic value of LA strain parameters in @entity1 with pathological @entity4346 . METHODS: This study included 95 @entity1 with @entity101 ( @entity19359 : n  =  24), @entity1121 (HCM: n  =  56), @entity299 (CA: n  =  15), and control subjects (n  =  20). We used two-dimensional speckle tracking echocardiography (STE) to analyze LA global strain. LA electromechanical conduction time (EMT) at the septal (EMT-septal) and lateral wall (EMT-lateral), and their time difference (EMT-diff) were calculated. The incidence of @entity204 and @entity712 hospitalization was defined as major @entity299 and that of @entity955 as secondary outcome. RESULTS: Left atrial volume index was increased and LA booster strain was decreased in the HCM and CA groups compared with the @entity19359 group. EMT-lateral was increased in the diseased groups compared with the control. EMT-diff was prolonged in the CA group compared with the HCM group. During the follow-up period (mean 3.4  years), major @entity299 and @entity955 occurred in 17 and 13 @entity1 , respectively. The occurrence of @entity955 was associated with CA etiology, E/e', LA volume index, LAa, and EMT-lateral. The incidence of major @entity299 was independently correlated with LA volume index and EMT-diff in multivariate analysis. CONCLUSION: This study suggested that the EMT-diff could discriminate @entity1 with a high risk of @entity299 among @entity1 with pathological @entity4346 .

title: Characteristics of Left Atrial Deformation Parameters and Their Prognostic Impact in @entity1 with Pathological XXXX : Analysis by Speckle Tracking Echocardiography.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive heart disease']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity4346 :: ('MESH:D017379', 'Disease') :: ['LV hypertrophy']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac amyloidosis', 'cardiac events']

entities_list: @entity1121 :: ('MESH:D002312', 'Disease') :: ['hypertrophic cardiomyopathy']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']

answer: @entity4346 :: (MESH:D017379,Disease) :: ['Left Ventricular Hypertrophy']


abstract: BACKGROUND: The pathological process of left ventricular (LV) @entity1184 is associated with left atrial (LA) remodeling. This study was aimed to evaluate the prognostic value of LA strain parameters in @entity1 with pathological @entity4346 . METHODS: This study included 95 @entity1 with @entity101 ( @entity19359 : n  =  24), @entity1121 (HCM: n  =  56), @entity299 (CA: n  =  15), and control subjects (n  =  20). We used two-dimensional speckle tracking echocardiography (STE) to analyze LA global strain. LA electromechanical conduction time (EMT) at the septal (EMT-septal) and lateral wall (EMT-lateral), and their time difference (EMT-diff) were calculated. The incidence of @entity204 and @entity712 hospitalization was defined as major @entity299 and that of @entity955 as secondary outcome. RESULTS: Left atrial volume index was increased and LA booster strain was decreased in the HCM and CA groups compared with the @entity19359 group. EMT-lateral was increased in the diseased groups compared with the control. EMT-diff was prolonged in the CA group compared with the HCM group. During the follow-up period (mean 3.4  years), major @entity299 and @entity955 occurred in 17 and 13 @entity1 , respectively. The occurrence of @entity955 was associated with CA etiology, E/e', LA volume index, LAa, and EMT-lateral. The incidence of major @entity299 was independently correlated with LA volume index and EMT-diff in multivariate analysis. CONCLUSION: This study suggested that the EMT-diff could discriminate @entity1 with a high risk of @entity299 among @entity1 with pathological @entity4346 .

title: Characteristics of Left Atrial Deformation Parameters and Their Prognostic Impact in XXXX with Pathological @entity4346 : Analysis by Speckle Tracking Echocardiography.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: 1. Cardiac haemodynamics were studied in 14 male @entity1 with phaeochromocytoma, in comparison with 33 normal male subjects and 65 males with essential @entity101 . 2. At the time of investigation, seven @entity1 with phaeochromocytoma were @entity101 and seven were normotensive. Cardiac output was within normal limits. Total peripheral resistance was elevated in the @entity101 @entity1 . Heart rate was elevated both in the normotensive and in the @entity101 @entity1 , but decreased after surgical treatment. 3. The relationships between blood volume and blood pressure and between blood volume and cardiac output were the same as those observed in the control groups. 4. During tilt, a predominant @entity20833 was observed and was associated with @entity64 and impaired adaptation of total peripheral resistance during tilt, indicating inadequate arteriolar and venous reflexes. 5. The study suggested that, except for @entity591 , the haemodynamic pattern of @entity1 with phaeochromocytoma and with essential @entity101 was nearly the same.

title: Haemodynamics in XXXX with phaeochromocytoma.

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['decreased stroke volume']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity20833 :: ('MESH:D007024', 'Disease') :: ['systolic orthostatic hypotension']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Obesity has been associated with poor prognosis in @entity0 . However, most previous studies examined populations with relatively low proportions of @entity28 @entity1 . Given that forecasts predict @entity28 rates to exceed 50% by 2030, it is important to examine @entity0 outcomes in populations with higher rates of @entity28 . We hypothesized that @entity28 , as measured by body mass index (BMI), is associated with decreased overall survival and disease-free survival in @entity1 with @entity0 in a population with a high prevalence of @entity28 . METHODS: A retrospective review of a prospectively maintained database was conducted on @entity1 treated for @entity0 at an academic medical center between 1997 and 2013. BMI was calculated from each @entity1 's height and weight at the time of diagnosis. @entity1 were categorized as normal (BMI <25  kg/m(2)), overweight (BMI 25-30  kg/m(2)), or @entity28 (BMI >30  kg/m(2)), as per the definitions established by the World Health Organization. The end points of overall survival and disease-free survival were analyzed. RESULTS: A total of 523 @entity1 with @entity0 were included for analysis. Based on BMI, 87 (16%) were categorized as normal, 150 (29%) were overweight, and 286 (55%) were @entity28 . The median follow-up was 49  mo. There were 16 deaths (18.4%) in normal @entity1 , 25 (16.7 %) in overweight @entity1 , and 45 (15.7%) in @entity28 @entity1 (P  =  0.84). By Kaplan-Meier survival analysis, there were no differences in overall survival (P  =  0.49) or in disease-free survival (P  =  0.33) among the three groups. CONCLUSIONS: Obesity is not associated with decreased overall or disease-free survival in a @entity1 population with a high prevalence of @entity28 . These findings suggest that there may be other factors that contribute to the poor prognosis of @entity0 @entity1 observed in populations with lower rates of @entity28 .

title: XXXX outcomes in a population with high prevalence of @entity28 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'obese breast cancer', 'invasive breast cancer']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast cancer']


abstract: BACKGROUND: Obesity has been associated with poor prognosis in @entity0 . However, most previous studies examined populations with relatively low proportions of @entity28 @entity1 . Given that forecasts predict @entity28 rates to exceed 50% by 2030, it is important to examine @entity0 outcomes in populations with higher rates of @entity28 . We hypothesized that @entity28 , as measured by body mass index (BMI), is associated with decreased overall survival and disease-free survival in @entity1 with @entity0 in a population with a high prevalence of @entity28 . METHODS: A retrospective review of a prospectively maintained database was conducted on @entity1 treated for @entity0 at an academic medical center between 1997 and 2013. BMI was calculated from each @entity1 's height and weight at the time of diagnosis. @entity1 were categorized as normal (BMI <25  kg/m(2)), overweight (BMI 25-30  kg/m(2)), or @entity28 (BMI >30  kg/m(2)), as per the definitions established by the World Health Organization. The end points of overall survival and disease-free survival were analyzed. RESULTS: A total of 523 @entity1 with @entity0 were included for analysis. Based on BMI, 87 (16%) were categorized as normal, 150 (29%) were overweight, and 286 (55%) were @entity28 . The median follow-up was 49  mo. There were 16 deaths (18.4%) in normal @entity1 , 25 (16.7 %) in overweight @entity1 , and 45 (15.7%) in @entity28 @entity1 (P  =  0.84). By Kaplan-Meier survival analysis, there were no differences in overall survival (P  =  0.49) or in disease-free survival (P  =  0.33) among the three groups. CONCLUSIONS: Obesity is not associated with decreased overall or disease-free survival in a @entity1 population with a high prevalence of @entity28 . These findings suggest that there may be other factors that contribute to the poor prognosis of @entity0 @entity1 observed in populations with lower rates of @entity28 .

title: @entity0 outcomes in a population with high prevalence of XXXX .

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: OBJECTIVE: @entity4518 ( @entity4518 ) contributes considerably to knee @entity571 symptoms. This study aimed to determine the efficacy of a PFJ-targeted exercise, education manual-therapy and taping program compared to @entity571 education alone, in @entity1 with @entity4518 . METHODS: A randomised, @entity1 -blinded and assessor-blinded clinical trial was conducted in primary-care physiotherapy. 92 @entity1 aged >= 40 years with symptomatic and radiographic @entity4518 participated. Physiotherapists delivered the PFJ-targeted exercise, education, manual-therapy and taping program, or the @entity571 (control condition) in eight sessions over 12 weeks. Primary outcomes at 3-month (primary) and 9-month follow-up: (1) @entity1 -perceived global rating of change (2) @entity158 visual analogue scale (VAS) (100  mm); and (3) activities of daily living (ADL) subscale of the @entity3331 and @entity571 Outcome Score (KOOS). RESULTS: 81 @entity1 (88%) completed the 3-month follow-up and data analysed on an intention-to-treat basis. Between-group baseline similarity for @entity1 characteristics was observed. The exercise, education, manual-therapy and taping program resulted in more @entity1 reporting much improvement (20/44) than the @entity571 group (5/48) (number needed to treat 3 (95% confidence interval (CI) 2 to 5)) and greater @entity158 reduction (mean difference:  -15.2  mm, 95% CI  -27.0 to  -3.4). No significant effects on ADL were observed (5.8; 95% CI  -0.6 to 12.1). At 9 months there were no significant effects for self-report of improvement, @entity158 (-10.5  mm, 95% CI  -22.7 to 1.8) or ADL (3.0, 95% CI  -3.7 to 9.7). CONCLUSION: Exercise, education, manual-therapy and taping can be recommended to improve short-term @entity1 rating of change and @entity158 severity. However over 9-months, both options were equivalent. TRIAL REGISTRATION: Australian New Zealand Clinical Trials Registry (ACTRN12608000288325): https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=82878.

title: Exercise, education, manual-therapy and taping compared to education for XXXX : a blinded, randomised clinical trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'patient', 'people']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis', 'OA', 'OA-education']

entities_list: @entity3331 :: ('MESH:D007718', 'Disease') :: ['Knee injury']

entities_list: @entity4518 :: ('MESH:D046788', 'Disease') :: ['PFJ OA', 'Patellofemoral joint osteoarthritis']

answer: @entity4518 :: (MESH:D046788,Disease) :: ['patellofemoral osteoarthritis']


abstract: UNASSIGNED: Nowadays, passive sampling is a widely applied technique to determine freely dissolved aqueous concentrations of hydrophobic organic chemicals (HOCs), such as @entity2555 ( @entity2556 ) and @entity3215 ( @entity3215 ). Crucial to the measurements are sampler-water partition coefficients, which are generally determined in the laboratory under "standard conditions" (in freshwater at 20   C). Theoretically, however, the coefficients are dependent on environmental conditions, such as temperature and salinity. Yet, there are insufficient experimental data in the scientific literature to prove this for different polymers. Several polymers are already being applied during field monitoring, however, and neglecting any effects may lead to imprecise results. In the present study, we therefore quantified the effects of temperature and salinity on the sampler-water partition coefficients of @entity2556 and @entity3215 for @entity1346 rubber, a material used in Dutch passive sampling monitoring campaigns. The results demonstrated a chemical-specific and hydrophobicity-dependent temperature effect, being independent of salinity, and a chemical- and temperature-independent salinity effect. Based on the obtained data, location-specific @entity1346 rubber-water partition coefficients (Ksr-w; adjusted for temperature and salinity) can be calculated. The impact of applying such location-specific values was demonstrated using the Dutch passive sampling field monitoring database, covering ten years of PAH and @entity21366 data for several locations. Adjusting the Ksr-w values resulted in aqueous concentrations that were lowered by a factor of 1.6 on average. The reduction was rather constant because of the manner of sampling (under nonequilibrium conditions and using performance reference compounds) and calculating. When sampling under equilibrium conditions in seawater at temperatures at about freezing, and/or applying different calculation approaches, the adjustment effect can potentially increase up to a factor of about 5-6 for the more hydrophobic @entity2556 and @entity3215 . Although this study exclusively focused on @entity1346 rubber, qualitatively the results will also apply to other passive sampling materials.

title: Quantifying the Effects of Temperature and Salinity on Partitioning of Hydrophobic Organic Chemicals to XXXX Rubber Passive Samplers.

entities_list: @entity2555 :: ('MESH:D011084', 'Chemical') :: ['polycyclic aromatic hydrocarbons']

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

entities_list: @entity3215 :: ('MESH:D011078', 'Chemical') :: ['polychlorinated biphenyls', 'PCBs']

answer: @entity1346 :: (MESH:D012828,Chemical) :: ['Silicone']


abstract: BACKGROUND: When an incurable fetal condition is detected, some @entity1 (or couples) would rather choose to continue with the pregnancy than opt for termination of pregnancy for medical reasons, which, in France, can be performed until full term. Such situations are frequently occurring and sometimes leading to the implementation of neonatal palliative care. The objectives of this study were to evaluate the practices of perinatal care french professionals in this context; to identify the potential obstacles that might interfere with the provision of an appropiate neonatal palliative care; and, from an opposite perspective, to determine the criteria that led, in some cases, to offer this type of care for prenatally diagnosed lethal abnormality. METHODS: We used an email survey sent to 434 maternal-fetal medicine specialists (MFMs) and fetal care pediatric specialists (FCPs) at 48 @entity146 ( @entity146 ). RESULTS: Forty-two @entity146 (87.5%) took part. In total, 102 MFMs and 112 FCPs completed the survey, yielding response rate of 49.3%. One quarter of professionals (26.2%) estimated that over 20% of fetal pathologies presenting in @entity146 could correspond to a diagnosis categorized as lethal (FCPs versus MFMs: 24% vs 17.2%, p = 0.04). The mean proportion of fetal abnormalities eligible for palliative care at birth was estimated at 19.30% (   2.4) (FCPs versus MFMs: 23.4% vs 15.2%, p = 0.029). The degree of diagnostic certainty appears to be the most influencing factor (98.1%, n = 207) in the information provided to the pregnant @entity1 with regard to potential neonatal palliative care. The vast majority of professionals, 92.5%, supported considering the practice of palliative care as a regular option to propose antenatally. CONCLUSIONS: Our study reveals the clear need for training perinatal professionals in perinatal palliative care and for the standardization of practices in this field.

title: Barriers in Referring Neonatal XXXX to Perinatal Palliative Care: A French Multicenter Survey.

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['MCPD', 'multidisciplinary centers for prenatal diagnosis']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: i-Scan is a novel virtual chromoendoscopy system designed to enhance surface and vascular patterns to improve optical diagnostic performance. Numerous prospective studies have been done to evaluate the accuracy of i-Scan in differentiating @entity694 from non-neoplasms. i-Scan could be an effective endoscopic technique for optical diagnosis of @entity1586 . OBJECTIVE: Our aim of this study was to perform a meta-analysis of published data to establish the diagnostic accuracy of i-Scan for optical diagnosis of @entity1586 . METHODS: We searched PubMed, Medline, Elsevier ScienceDirect and Cochrane Library databases. We used a bivariate meta-analysis following a random effects model to summarize the data and plotted hierarchical summary receiver-operating characteristic (HSROC) curves. The area under the HSROC curve (AUC) serves as an indicator of the diagnostic accuracy. RESULTS: The meta-analysis included a total of 925 @entity1 and 2312 @entity1127 . For the overall studies, the area under the HSROC curve was 0.96. The summary sensitivity was 90.4% (95%CI 85%-94.1%) and specificity was 90.9% (95%CI 84.3%-94.9%). In 11 studies predicting @entity1127 histology in real-time, the summary sensitivity and specificity was 91.5% (95%CI 85.7%-95.1%) and 92.1% (95%CI 84.5%-96.1%), respectively, with the AUC of 0.97. For three different diagnostic criteria (Kudo, NICE, others), the sensitivity was 86.3%, 93.0%, 85.0%, respectively and specificity was 84.8%, 94.4%, 91.8%, respectively. CONCLUSIONS: Endoscopic diagnosis with i-Scan has accurate optical diagnostic performance to differentiate neoplastic from non-neoplastic @entity1127 with an area under the HSROC curve exceeding 0.90. Both the sensitivity and specificity for diagnosing @entity1586 are over 90%.

title: Accuracy of i-Scan for Optical Diagnosis of XXXX : A Meta-Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colonic neoplasms']

entities_list: @entity1586 :: ('MESH:D003111', 'Disease') :: ['colonic polyps']

answer: @entity1586 :: (MESH:D003111,Disease) :: ['Colonic Polyps']


abstract: @entity12119 was used to treat 131 out of 250 @entity1 with @entity1793 over 10 years. Other antimicrobial agents were given to the 119 remaining @entity1 . Thirty-seven @entity1 were @entity1087 before antibiotic treatment was started. @entity1087 developed during treatment in 38 out of 112 @entity1 given @entity12119 (34%) and in two out of 101 @entity1 given other antimicrobials. The incidence of @entity1087 was higher in @entity1 given @entity12119 intravenously (48%) rather than by mouth (13%). @entity1087 appeared within 48 hours after the administration of @entity12119 in 93% of these cases. When the drug was stopped serum @entity648 concentrations fell to normal values within four days in those @entity1 in whom they had been previously normal and who survived the bacteraemic episode. @entity12119 was associated with increasing @entity1087 in 13 of 19 @entity1 (68%) @entity1087 before it was given. In six out of 32 @entity1 who developed @entity1087 while receiving intravenous @entity12119 serum alkaline phosphatase activity was raised suggestive of @entity3883 . The mechanism in the remaining @entity1 was unknown. @entity12119 , particularly the intravenous preparation, in invaluable in treating severe @entity1793 but should be used with caution in @entity1 with @entity409 . @entity1 receiving intravenous @entity12119 should be given the oral form of the drug as soon as their clinical condition permits.

title: @entity1793 , @entity12119 , and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3883 :: ('MESH:D041781', 'Disease') :: ['cholestatic jaundice']

entities_list: @entity1087 :: ('MESH:D007565', 'Disease') :: ['jaundice', 'already jaundiced', 'Jaundice']

entities_list: @entity12119 :: ('MESH:D005672', 'Chemical') :: ['fusidic acid', 'Fusidic acid']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['abnormal liver function']

entities_list: @entity1793 :: ('MESH:D013203', 'Disease') :: ['staphylococcal bacteraemia', 'staphylococcal infection']

answer: @entity1087 :: (MESH:D007565,Disease) :: ['jaundice']


abstract: @entity12119 was used to treat 131 out of 250 @entity1 with @entity1793 over 10 years. Other antimicrobial agents were given to the 119 remaining @entity1 . Thirty-seven @entity1 were @entity1087 before antibiotic treatment was started. @entity1087 developed during treatment in 38 out of 112 @entity1 given @entity12119 (34%) and in two out of 101 @entity1 given other antimicrobials. The incidence of @entity1087 was higher in @entity1 given @entity12119 intravenously (48%) rather than by mouth (13%). @entity1087 appeared within 48 hours after the administration of @entity12119 in 93% of these cases. When the drug was stopped serum @entity648 concentrations fell to normal values within four days in those @entity1 in whom they had been previously normal and who survived the bacteraemic episode. @entity12119 was associated with increasing @entity1087 in 13 of 19 @entity1 (68%) @entity1087 before it was given. In six out of 32 @entity1 who developed @entity1087 while receiving intravenous @entity12119 serum alkaline phosphatase activity was raised suggestive of @entity3883 . The mechanism in the remaining @entity1 was unknown. @entity12119 , particularly the intravenous preparation, in invaluable in treating severe @entity1793 but should be used with caution in @entity1 with @entity409 . @entity1 receiving intravenous @entity12119 should be given the oral form of the drug as soon as their clinical condition permits.

title: @entity1793 , XXXX , and @entity1087 .

answer: @entity12119 :: (MESH:D005672,Chemical) :: ['fusidic acid']


abstract: @entity12119 was used to treat 131 out of 250 @entity1 with @entity1793 over 10 years. Other antimicrobial agents were given to the 119 remaining @entity1 . Thirty-seven @entity1 were @entity1087 before antibiotic treatment was started. @entity1087 developed during treatment in 38 out of 112 @entity1 given @entity12119 (34%) and in two out of 101 @entity1 given other antimicrobials. The incidence of @entity1087 was higher in @entity1 given @entity12119 intravenously (48%) rather than by mouth (13%). @entity1087 appeared within 48 hours after the administration of @entity12119 in 93% of these cases. When the drug was stopped serum @entity648 concentrations fell to normal values within four days in those @entity1 in whom they had been previously normal and who survived the bacteraemic episode. @entity12119 was associated with increasing @entity1087 in 13 of 19 @entity1 (68%) @entity1087 before it was given. In six out of 32 @entity1 who developed @entity1087 while receiving intravenous @entity12119 serum alkaline phosphatase activity was raised suggestive of @entity3883 . The mechanism in the remaining @entity1 was unknown. @entity12119 , particularly the intravenous preparation, in invaluable in treating severe @entity1793 but should be used with caution in @entity1 with @entity409 . @entity1 receiving intravenous @entity12119 should be given the oral form of the drug as soon as their clinical condition permits.

title: XXXX , @entity12119 , and @entity1087 .

answer: @entity1793 :: (MESH:D013203,Disease) :: ['Staphylococcal bacteraemia']


abstract: A total of 813 @entity1 admitted to Roswell Park Memorial Institute from 1963--1972 with @entity1893 ( @entity1893 ) were reviewed for gastrointestinal (GI) involvement. Primary involvement was found in 71 and secondary involvement in 31 @entity1 . Occult GI involvement was detected in 46% of the autopsy cases. The median survival time after the diagnosis of secondary GI involvement was nine months. The occurrence of primary @entity1893 was: 33 in the stomach, 18 in the small intestine, 14 in the ileocecal area including appendix, and 6 in the large intestine. Retrospective staging according to the Ann Arbor staging classification showed 24 to have presented as Stage I, 30 as Stage II, 4 as Stage III, and 13 as Stage IV. The primary diagnostic and therapeutic approach was operative, except in 2 @entity1 with @entity706 . Resection of the principally involved site was carried out in 42 @entity1 . The remainder had palliative procedures or biopsy examinations only. Postoperative radiation therapy was given to 38 @entity1 . Prognostically important features for primary @entity1893 were: stage; histologic type; site of the @entity66 ; and whether or not radiotherapy was administered. The age of the @entity1 , size or degree of local extension, and type of operative procedure were prognostically of no importance. The results of this study would indicate that in Stage I and II primary @entity1893 , elective resection is not necessary prior to radiation therapy and that resection alone cannot be considered adequate treatment. A modified staging classification is proposed.

title: Gastrointestinal involvement in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'GI-NHL', "non Hodgkin's lymphoma"]

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['rectal lymphoma']

answer: @entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin's lymphoma']


abstract: UNASSIGNED: The primary aim of our meta-analysis was to evaluate the effects of cathodal transcranial direct current stimulation (c-tDCS) on sensory and @entity158 thresholds ( @entity24873 and @entity461 ) in healthy individuals and @entity158 level (PL) in @entity1 with @entity1118 . Electronic databases were searched for c-tDCS studies. Methodological quality was evaluated using the PEDro and Downs and Black (D_B) assessment tools. C-tDCS of the primary motor cortex (S1) increases both @entity24873 (P<0.001, effect size of 26.84%) and @entity461 (P<0.001, effect size of 11.62%). In addition, c-tDCS over M1 led to @entity24873 increase (P<0.005, effect size of 30.44%). Likewise, PL decreased significantly in the @entity1 group following application of c-tDCS. The small number of studies precluded subgroup analysis. Nevertheless, meta-analysis showed that in all groups (except c-tDCS of S1) active c-tDCS and sham stimulation produced significant differences in @entity24873 / @entity461 in healthy and PL in @entity1 group. This review provides evidence for the site-specific effectiveness of c-tDCS in increasing @entity24873 / @entity461 in healthy individuals and decreasing PL in @entity1 with @entity1118 . However, due to small sample sizes in the included studies, our results should be interpreted with caution. Given that the level of blinding was not considered in the inclusion criteria, the results of the current study should be interpreted with caution.

title: A Meta-Analysis of Site-Specific Effects of Cathodal Transcranial Direct Current Stimulation on Sensory Perception and XXXX .

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: PURPOSE: To develop a neural-network based autocontouring algorithm for intrafractional @entity2 tracking using Linac-MR and evaluate its performance with phantom and in-vivo MR images. METHODS: An autocontouring algorithm was developed to determine both the shape and position of a @entity2 from each intrafractional MR image. A pulse-coupled neural network was implemented in the algorithm for contrast improvement of the @entity5 region. Prior to treatment, to initiate the algorithm, an expert user needs to contour the @entity5 and its maximum anticipated range of motion in pretreatment MR images. During treatment, however, the algorithm processes each intrafractional MR image and automatically generates a @entity5 contour without further user input. The algorithm is designed to produce a @entity5 contour that is the most similar to the expert's manual one. To evaluate the autocontouring algorithm in the author's Linac-MR environment which utilizes a 0.5 T MRI, a motion phantom and four @entity2 @entity1 were imaged with 3 T MRI during normal breathing, and the image noise was degraded to reflect the image noise at 0.5 T. Each of the pseudo-0.5 T images was autocontoured using the author's algorithm. In each test image, the Dice similarity index (DSI) and @entity5529 ( @entity5529 ) between the expert's manual contour and the algorithm generated contour were calculated, and their centroid positions were compared (  dcentroid). RESULTS: The algorithm successfully contoured the shape of a moving @entity5 from dynamic MR images acquired every 275 ms. From the phantom study, mean DSI of 0.95-0.96, mean @entity5529 of 2.61-2.82 mm, and mean   dcentroid of 0.68-0.93 mm were achieved. From the in-vivo study, the author's algorithm achieved mean DSI of 0.87-0.92, mean @entity5529 of 3.12-4.35 mm, as well as   dcentroid of 1.03-1.35 mm. Autocontouring speed was less than 20 ms for each image. CONCLUSIONS: The authors have developed and evaluated a @entity2 autocontouring algorithm for intrafractional @entity5 tracking using Linac-MR. The autocontouring performance in the Linac-MR environment was evaluated using phantom and in-vivo MR images. From the in-vivo study, the author's algorithm achieved 87%-92% of contouring agreement and centroid tracking accuracy of 1.03-1.35 mm. These results demonstrate the feasibility of @entity2 autocontouring in the author's laboratory's Linac-MR environment.

title: Neural-network based autocontouring algorithm for intrafractional XXXX tracking using Linac-MR.

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung-tumor', 'lung cancer', 'lung tumor']

entities_list: @entity5529 :: ('MESH:C535290', 'Disease') :: ['HD', 'Hausdorff distance']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung-tumor']


abstract: OBJECTIVE: Intrathoracic @entity834 after intended curative resection for @entity5 in the esophagus or gastroesophageal junction has a negative impact on long-term survival. The aim of this study was to investigate whether an @entity834 was associated with an increased recurrence rate. METHODS: This nationwide study included consecutively collected data on @entity1 undergoing curative surgical resection with intrathoracic @entity254 , alive 8 weeks postoperatively, between 2003 and 2011. @entity1 with incomplete resection, or metastatic disease intraoperatively, were excluded. Only biopsy-proven recurrences were accepted. RESULTS: In total, 1085 @entity1 were included. The frequency of @entity834 was 8.6%. The median follow-up time was 29 months (interquartile range [IQR]: 13-58 months). Overall, 369 (34%) @entity1 had disease recurrence, of which 346 @entity1 died of recurrent @entity189 . Twenty-three @entity1 were alive with recurrence at the censoring date. In the study period, 333 @entity1 died without signs of recurrent disease. The overall median time to recurrence was 66 weeks (IQR: 38-109 weeks). Distant @entity3 were found in 267 (25%), and local disease recurrence in 102 (9%) @entity1 . Overall, 5-year disease-free survival in @entity1 with leakage was 27%, versus 39% in those without leakage (P = .017). @entity834 was independently associated with higher risk of recurrence (hazard ratio [HR] = 1.63; 95% confidence interval [CI]: 1.17-2.29, P = .004) and all-cause mortality (HR = 1.57; 95% CI: 1.23-2.05, P < .0001). CONCLUSIONS: Intrathoracic @entity834 increased the risk of recurrence in @entity1 who underwent curative @entity5 resection.

title: Intrathoracic XXXX after @entity5 resection is associated with increased risk of recurrence.

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['Anastomotic leakage', 'anastomotic leakage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'gastroesophageal cancer']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['gastroesophageal carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity834 :: (MESH:D057868,Disease) :: ['anastomotic leakage']


abstract: OBJECTIVE: Intrathoracic @entity834 after intended curative resection for @entity5 in the esophagus or gastroesophageal junction has a negative impact on long-term survival. The aim of this study was to investigate whether an @entity834 was associated with an increased recurrence rate. METHODS: This nationwide study included consecutively collected data on @entity1 undergoing curative surgical resection with intrathoracic @entity254 , alive 8 weeks postoperatively, between 2003 and 2011. @entity1 with incomplete resection, or metastatic disease intraoperatively, were excluded. Only biopsy-proven recurrences were accepted. RESULTS: In total, 1085 @entity1 were included. The frequency of @entity834 was 8.6%. The median follow-up time was 29 months (interquartile range [IQR]: 13-58 months). Overall, 369 (34%) @entity1 had disease recurrence, of which 346 @entity1 died of recurrent @entity189 . Twenty-three @entity1 were alive with recurrence at the censoring date. In the study period, 333 @entity1 died without signs of recurrent disease. The overall median time to recurrence was 66 weeks (IQR: 38-109 weeks). Distant @entity3 were found in 267 (25%), and local disease recurrence in 102 (9%) @entity1 . Overall, 5-year disease-free survival in @entity1 with leakage was 27%, versus 39% in those without leakage (P = .017). @entity834 was independently associated with higher risk of recurrence (hazard ratio [HR] = 1.63; 95% confidence interval [CI]: 1.17-2.29, P = .004) and all-cause mortality (HR = 1.57; 95% CI: 1.23-2.05, P < .0001). CONCLUSIONS: Intrathoracic @entity834 increased the risk of recurrence in @entity1 who underwent curative @entity5 resection.

title: Intrathoracic @entity834 after XXXX resection is associated with increased risk of recurrence.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

answer: @entity5 :: (MESH:D009369,Disease) :: ['gastroesophageal cancer']


abstract: UNASSIGNED: @entity3091 ( @entity17054 ) is a natural compound that has been investigated as a chemopreventative agent. @entity17054 has been shown to suppresses ultraviolet B (UVB)-induced @entity1996 ( @entity1996 ) protein expression and reduce the incidence of UVB-induced @entity1489 in @entity19 . Despite @entity17054 's promise as a therapeutic agent, minimal information is available to guide the progression of formulations designed for future drug development. Here, data is presented describing the solid-state and solution characterization of @entity17054 . Investigation into the solid-state properties of @entity17054 identified four different crystal forms, two hydrates ( @entity17054 I and @entity17054 II) and two metastable forms ( @entity17054 IA and @entity17054 IIA). From solubility studies, it was evident that all forms are very insoluble (<5  g/ml) in pure water. @entity17054 I was found to be the most stable form at 23, 35, and 56  C. Stability determination indicated that @entity17054 undergoes rapid apparent first-order degradation under basic pH conditions, and that degradation was influenced by buffer species. Apparent first-order degradation was also seen when @entity17054 was introduced to an oxidizing solution. Improved stability was achieved after introducing 0.1% antioxidants to the solution. @entity17054 was found to have good stability following exposure to ultraviolet radiation (UVR), which is a consideration for topical applications. Finally, a partitioning study indicated that @entity17054 possess a log P of 2.94 which, along with its solid-state properties, contributes to its poor aqueous solubility. Both the solid-state properties and solution stability of @entity17054 are important to consider when developing future formulations.

title: Solid-State and Solution Characterization of XXXX .

entities_list: @entity3091 :: ('MESH:C040015', 'Chemical') :: ['Myricetin']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin tumors']

answer: @entity3091 :: (MESH:C040015,Chemical) :: ['Myricetin']


abstract: @entity4822 is a severe injury. Even in cases of an early uncomplicated repositioning there is a high risk of associated intra-articular injuries, such as lesions of the labrum, ruptures of the ligament of the head of the femur and loose bodies. The degree of damage caused by @entity572 becomes apparent with a highly increased risk of developing @entity571 after @entity572 . Some of the major @entity16 resulting from @entity572 , e.g. loose bodies, can be detected by computed tomography and magnetic resonance imaging and can be effectively addressed by hip arthroscopy, thus aiming at reducing the acute symptoms and the risk of @entity571 . The force effect which causes @entity572 can generate severe associated extra-articular injures as in the case described with an unstable @entity174 of the pelvis. This @entity130 had to be considered while planning the operative therapy and rehabilitation. A @entity1 presented after a traffic accident with a luxatio obturatoria on the right side and a complex @entity174 of the left pelvis including the posterior ring and the anterior wall of the acetabulum. After reposition of the right hip and operative therapy of the left side, a loose body was identified in the right hip joint during the computed tomography control of the osteosynthesis. Before @entity1 mobilization extraction of the @entity7334 was performed arthroscopically. This was done in consideration of the reduced possibility of distraction due to the osteosynthesis on the contralateral side. Attention was particularly paid to the risk of intra-abdominal fluid extravasation (IAFE). This syndrome is described as a severe complication during hip arthoscopy especially in cases of defects of the hip capsule as assumed after @entity572 and magnetic resonance imaging.

title: [Hip arthroscopy after luxatio obturatoria. With contralateral unstable pelvic ring XXXX ].

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['postinjury osteoarthritis']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['supplementary injury']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['intra-articular damage']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['hip dislocation', 'dislocation of the hip']

entities_list: @entity7334 :: ('MESH:D057072', 'Disease') :: ['intra-articular loose body']

entities_list: @entity4822 :: ('MESH:D025981', 'Disease') :: ['Traumatic dislocation of the hip']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture']


abstract: BACKGROUND: Inguinal hernias account for 75% of abdominal wall hernias, with a lifetime risk of 27% in @entity1 and 3% in @entity1 . Major complications are recurrence, @entity1118 , and @entity281 , but their frequency is low. Few studies have reported a calcified mesh causing @entity16 by chronic compression of the femoral nerve after mesh _ plug @entity169 . This is the first report of laparoscopic plug removal for femoral colic due to femoral nerve irritation cause by a calcified plug after mesh _ plug @entity169 . CASE PRESENTATION: In July 2013, a 53-year-old @entity1 presented to our hospital with a chief complaint of @entity158 in the left lower limb while walking. The @entity1 had undergone @entity169 about 10 years earlier and reported no @entity1118 after the operation. Physical examination revealed a @entity158 exacerbated by left thigh movement, especially during flexion, but the @entity1 was @entity158 -free at rest and had no sensory loss. Axial computed tomography and magnetic resonance imaging showed that the inward-projecting plug was extremely close to the femoral nerve. Because of the radicular symptoms and the absence of orthopedic and @entity5450 , we strongly suspected that the @entity9 was associated with the previous @entity547 operation and advised exploratory laparotomy, which revealed the plug bulging inward into the abdominal cavity. Moreover, the tip of the plug was firmly calcified and compressing the femoral nerve, which lay just beneath the plug, especially during hip flexion. We explanted the plug and his @entity158 resolved after the operation. The @entity1 remains @entity158 free after 20 months of follow up. CONCLUSION: In this study, laparoscopic hernioplasty proved useful for plug removal because laparoscopic instruments can easily grasp perilesional tissue, and laparoscopic approach has the benefit of isolating the plug for removal while preserving the onlay patch, and helpful for restoring peritoneal defects. Laparoscopic plug removal effectively resolved @entity158 in the left thigh due to compression of the femoral nerve by a calcified plug.

title: Laparoscopic plug removal for femoral nerve XXXX after mesh _ plug hernioplasty.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient', 'man', 'men']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity5450 :: ('MESH:D014570', 'Disease') :: ['urological disease']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['surgical site infection']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['colic pain', 'pain']

entities_list: @entity169 :: ('MESH:D006552', 'Disease') :: ['left inguinal hernia repair', 'inguinal hernia repair']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuralgia']

answer: @entity158 :: (MESH:D010146,Disease) :: ['colic pain']


abstract: BACKGROUND: The Pulmonary-specific Quality-of-Life Scale (PQLS) was developed to measure quality of life (QoL) among @entity1 awaiting lung transplant. The objective of this study was to determine the psychometric properties of the PQLS, identify empirically derived sub-scales, and examine ability to detect changes in pulmonary-specific QoL scores after lung transplantation. METHODS: Data were derived from the INSPIRE trial, a dual-site randomized controlled trial of coping skills training in 389 lung transplant candidates (obstructive [48.3%], restrictive [24.2%], cystic @entity82 [13.6%], and other [13.9%]). Cronbach alpha was calculated to assess the internal reliability of the PQLS (n = 388). Test-retest reliability was assessed with correlation coefficients between baseline and 12-week post-baseline scores for the usual care control condition (n = 140). Convergent validity was assessed with correlation coefficients between the PQLS and established measures of @entity147 , 6-minute walk test distance, forced expiratory volume in 1 second, and use of supplemental @entity26 at rest (n = 388). Change from baseline to 6 months post-transplantation was assessed with repeated measures analysis of variance (n = 133). RESULTS: The PQLS was internally reliable and stable across 12 weeks. The PQLS correlated strongly with QoL measures (e.g., Shortness of Breath Questionnaire, r = 0.78, p < 0.0001), moderately with mood and @entity148 (e.g., Beck Depression Inventory-II, r = 0.59, p < 0.0001), and modestly with @entity358 severity (e.g., 6-minute walk test, r = -0.41, p < 0.0001). PQLS scores improved by nearly 2 SDs after transplant. CONCLUSIONS: These results demonstrated the reliability, validity, and sensitivity to change of the PQLS for measuring pulmonary QoL among @entity1 with @entity358 and the responsiveness of the PQLS to changes in QoL after lung transplantation.

title: Development and psychometric properties of the Pulmonary-specific Quality-of-Life Scale in lung transplant XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity147 :: ('MESH:D005316', 'Disease') :: ['QoL and emotional distress']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung disease', 'advanced lung disease']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: @entity0 is the most common female @entity5 . The aim of this study was to assess the impact of yoga on @entity4269 in @entity0 survivors. DESIGN: Repeated measures before and after the intervention. We enrolled 15 @entity1 with @entity0 who had not previously worn elastic clothing to treat @entity4269 . METHODS: The program was led by a certified trainer and consisted of 60-minute sessions, three times a week for 12 weeks. The volumes of the affected and normal limbs were measured. A self-assessed @entity4 score was also recorded. FINDINGS: Fifteen @entity1 completed the program, none of whom suffered from complications related to exercise. There was no significant @entity4 after exercise. No significant differences were noted in subgroup analysis by age or the affected arm. CONCLUSIONS: Yoga does not induce @entity4269 . CLINICAL RELEVANCE: @entity4269 is usually treated with uncomfortable elastic clothing, and high-resistance exercise may induce @entity4 . Yoga may be suitable for these @entity1 .

title: The Effects of Upper Limb Exercise Through Yoga on Limb Swelling in Chinese XXXX Survivors - A Pilot Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity4269 :: ('MESH:D008209', 'Disease') :: ['Lymphedema', 'lymphedema']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']


abstract: BACKGROUND: @entity5 loci comprise heterogeneous cell populations with diverse cellular secretions. Therefore, disseminating @entity5 -associated protein antigens from tissue lysates could only be marginally correct, if otherwise not validated against precise standards. MATERIALS AND METHODS: In this study, 2DE proteomic profiles were examined from lysates of 13 lung- @entity420 tissue samples and matched against the A549 cell line proteome. A549 matched- @entity5 -specific hits were analyzed and characterized by MALDI-TOF/MS. RESULTS: Comparative analysis identified a total of 13 protein spots with differential expression. These proteins were found to be involved in critical cellular functions regulating @entity7391 metabolism, @entity36435 pathway and integrin signaling. Gene ontology based analysis classified majority of protein hits responsible for metabolic processes. Among these, only a single non-predictive protein spot was found to be a @entity5 cell specific hit, identified as @entity71828 ( @entity71828 ). Pathway reconstruction studies showed that @entity71828 lies at the centre of @entity5 metabolic pathways. CONCLUSIONS: The findings in this report are suggestive of a regulatory role of @entity71828 in control of proliferation and @entity2220 .

title: Comparative proteomics and global genome-wide expression data implicate role of XXXX in lung cancer.

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['differentiation in lung adenocarcinomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer-specific or cancer', 'cancer', 'Cancer']

entities_list: @entity36435 :: ('D010428', 'Chemical') :: ['pentose phosphate']

entities_list: @entity71828 :: ('25852', 'Gene') :: ['Armadillo repeat-containing protein 8', 'ARMC8']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity7391 :: ('MESH:C030986', 'Chemical') :: ['pyrimidine']

answer: @entity71828 :: (25852,Gene) :: ['ARMC8']


abstract: BACKGROUND: The neutrophil/lymphocyte ratio (NLR) is a simple index of systemic inflammatory response, and has been shown to be a prognostic indicator in some types of @entity5 . @entity32 has been implicated in the initiation and progression of @entity259 . The aim of this study was to examine the relationship of NLR with @entity3557 ( @entity3557 ) and different benign thyroid pathologies like @entity1376 ( @entity1376 ) and @entity1669 ( @entity1669 ). MATERIALS AND METHODS: We retrospectively evaluated the neutrophil, lymphocyte counts and NLR calculated from these parameters of 232 @entity1 with histologically confirmed as @entity1376 (group @entity1376 ) (n=70), @entity1669 (group @entity1669 ) (n=97), @entity1669 with @entity3557 (group @entity1669 - @entity3557 ) (n=25) and @entity3557 (group @entity3557 ) (n=40). The optimal cut-off value for NLR was determined. RESULTS: NLR level was significantly higher in groups @entity1669 - @entity3557 and @entity3557 as compared to groups @entity1376 and @entity1669 (p<0.05). NLR of @entity1669 subgroups according to TSH levels were not different (p>0.05). When we grouped the @entity1 as benign and malignant according to @entity3557 presence, the optimum NLR cut-off point obtained from ROC analysis was 1.91 (sensitivity 89.0% and specificity 54.5%). CONCLUSIONS: Since NLR was significantly elevated in group @entity1669 - @entity3557 and group @entity3557 , NLR value may give an opinion as a potential marker in differentiation of benign and @entity1374 . For this purpose a cut-off value of 1.91 for NLR may be accepted.

title: May the neutrophil/lymphocyte ratio be a predictor in the differentiation of different XXXX ?

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['PTC', 'papillary thyroid cancer']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation']

entities_list: @entity1669 :: ('MESH:D013967', 'Disease') :: ['LT', 'lymphocytic thyroiditis']

entities_list: @entity1376 :: ('MESH:C564546', 'Disease') :: ['MNG', 'multinodular goiter']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['malign thyroid disorders']

answer: @entity1374 :: (MESH:D013959,Disease) :: ['thyroid disorders']


abstract: UNASSIGNED: Some studies suggest that even in euthyroid subjects, thyroid function may affect @entity1294 factors. We aimed to determine whether @entity8789 or thyroid autoantibodies are associated with arterial stiffness in middle-aged and elderly Chinese subjects with euthyroidism. A cross-sectional, population-based study was conducted in Nanjing, China. A total of 812 euthyroid subjects (mean age [56.75      8.34] years; 402 @entity1 ) without @entity455 and major @entity1294 factors were included. Clinical factors, oral @entity413 tolerance test results, homeostasis model assessment for insulin resistance (HOMA-IR) results, and serum levels of lipids, free @entity1954 (FT3), free @entity1955 (FT4), thyroid-stimulating hormone (TSH), and thyroid autoantibodies were measured. Arterial stiffness was assessed using brachial-ankle pulse wave velocity (baPWV). In Pearson correlation analyses, baPWV correlated inversely with FT4 (r  =  -0.146, P  <  0.001), but not with FT3 (r  =  0.008, P  =  0.816) or TSH (r  =  0.055, P  =  0.118). Subsequently, a multiple stepwise regression analysis revealed a significant and independent association of FT4 with baPWV in euthyroid subjects (b  =  -0.076, P  =  0.005). After adjusting for potential cardiovascular risk factors, mean diastolic blood pressure (DBP), HOMA-IR, and baPWV levels decreased across increasing FT4 quartiles (DBP, P  <  0.001; HOMA-IR, P  <  0.001; baPWV, P  =  0.003). No difference in baPWV was observed between the positive and the negative thyroid antibody groups (15.23      3.30  m/s vs. 15.73      3.05  m/s, P  >  0.05). FT4 levels were inversely associated with arterial stiffness in euthyroid subjects. A prospective study is warranted to validate whether subjects with low-normal FT4 levels have a high incidence of @entity65 .

title: Low serum free XXXX concentrations associate with increased arterial stiffness in euthyroid subjects: a population-based cross-sectional study.

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease']

entities_list: @entity1294 :: ('MESH:D015140', 'Disease') :: ['arteriosclerotic risk']

entities_list: @entity8789 :: ('MESH:D013963', 'Chemical') :: ['thyroid hormones']

entities_list: @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity1954 :: ('MESH:D014284', 'Chemical') :: ['triiodothyronine']

answer: @entity1955 :: (MESH:D013974,Chemical) :: ['thyroxine']


abstract: BACKGROUND: The rate of @entity1755 correlates with the @entity439 's diameter, and a higher rate of @entity397 is observed in @entity1 with larger @entity439 . According to the literature, contradictory results concerning the relationship between atmospheric pressure and @entity439 size have been reported. AIM: In this paper, we assessed the influence of changes in atmospheric pressure on abdominal @entity1756 in relationship to the @entity439 's size. METHODS: The records of 223 @entity1 with @entity1756 were evaluated. All of the @entity1 had been admitted to the department in the period 1997-2007 from the Silesia region. The atmospheric pressures on the day of the @entity397 and on the days both before the @entity397 and between the @entity397 events were compared. The size of the @entity439 was also considered in the analysis. RESULTS: There were no statistically significant differences in pressure between the days of @entity397 and the remainder of the days within an analysed period. The highest frequency of the admission of @entity1 with a @entity1755 was observed during periods of winter and spring, when the highest mean values of atmospheric pressure were observed; however, this observation was not statistically confirmed. A statistically non-significant trend towards the higher @entity397 of large @entity439 (> 7 cm) was observed in the cases where the pressure increased between the day before the @entity397 and the day of the @entity397 . This trend was particularly pronounced in @entity1 suffering from @entity101 (p = 0.1). CONCLUSIONS: The results of this study do not support the hypothesis that there is a direct link between atmospheric pressure values and @entity1755 .

title: The influence of atmospheric pressure on @entity1755 - is the diameter of the XXXX important?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1755 :: ('MESH:D001019', 'Disease') :: ['ruptured aortic aneurysm', 'aortic aneurysm rupture', 'abdominal aortic aneurysm ruptures']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['aneurysm ruptures', 'ruptured abdominal aneurysms']

answer: @entity439 :: (MESH:D000783,Disease) :: ['aneurysm']


abstract: BACKGROUND: The rate of @entity1755 correlates with the @entity439 's diameter, and a higher rate of @entity397 is observed in @entity1 with larger @entity439 . According to the literature, contradictory results concerning the relationship between atmospheric pressure and @entity439 size have been reported. AIM: In this paper, we assessed the influence of changes in atmospheric pressure on abdominal @entity1756 in relationship to the @entity439 's size. METHODS: The records of 223 @entity1 with @entity1756 were evaluated. All of the @entity1 had been admitted to the department in the period 1997-2007 from the Silesia region. The atmospheric pressures on the day of the @entity397 and on the days both before the @entity397 and between the @entity397 events were compared. The size of the @entity439 was also considered in the analysis. RESULTS: There were no statistically significant differences in pressure between the days of @entity397 and the remainder of the days within an analysed period. The highest frequency of the admission of @entity1 with a @entity1755 was observed during periods of winter and spring, when the highest mean values of atmospheric pressure were observed; however, this observation was not statistically confirmed. A statistically non-significant trend towards the higher @entity397 of large @entity439 (> 7 cm) was observed in the cases where the pressure increased between the day before the @entity397 and the day of the @entity397 . This trend was particularly pronounced in @entity1 suffering from @entity101 (p = 0.1). CONCLUSIONS: The results of this study do not support the hypothesis that there is a direct link between atmospheric pressure values and @entity1755 .

title: The influence of atmospheric pressure on XXXX - is the diameter of the @entity439 important?

answer: @entity1755 :: (MESH:D001019,Disease) :: ['aortic aneurysm rupture']


abstract: PURPOSE: We aimed to retrospectively assess the long-term safety and efficacy of embolization of renal arteries ( @entity7971 ) in @entity1 with @entity8 ( @entity8 ) before renal transplantation. MATERIAL AND METHODS: Between January 2008 and November 2013, 82 @entity7971 procedures were performed on 76 kidneys in 73 @entity1 (mean age 53 years, range: 34-72). All @entity1 had @entity703 and were under dialysis and on the renal transplant waiting list with a temporary contraindication due to excessive renal volume. RESULTS: @entity7971 was considered successful in 89.5% (68/76) of embolized kidneys, meaning that the temporary contraindication for transplantation could be withdrawn for 65 @entity1 (on average 5.6 months, range: 2.8-24.3, after @entity7971 ). Mean volume reduction was 40 (range: 2-69) at 3 months and 59% (35-86) thereafter (both p   <   0.001). @entity887 occurred after 15 of 82 procedures (18.3%). The severe complication rate was 4.9%. Forty-three (67.7%) transplantations were successfully conducted after @entity7971 , with a mean follow-up of 26.2 months (range: 1.8-59.5), and the estimated 5-year graft survival rate was 95.3% [95% CI: 82.7-98.8]. CONCLUSIONS: @entity7971 is a safe and effective alternative to nephrectomy before renal transplantation in @entity1 with @entity8 . KEY POINTS:     Embolization of non-functioning polycystic kidneys allowed transplantation in 89.5% of cases.     Technical failure rate was 7.9% after embolization, irrespective of the technique used.     @entity887 occurred after 18.3% of the procedures.     A low rate of severe complications (4.9%) was observed after renal embolization.

title: Embolization of renal arteries before transplantation in @entity1 with XXXX : a single institution long-term experience.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['PKD', 'polycystic kidney disease']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['Post-embolization syndrome']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['terminal-stage PKD']

answer: @entity8 :: (MESH:D007674,Disease) :: ['polycystic kidney disease']


abstract: PURPOSE: We aimed to retrospectively assess the long-term safety and efficacy of embolization of renal arteries ( @entity7971 ) in @entity1 with @entity8 ( @entity8 ) before renal transplantation. MATERIAL AND METHODS: Between January 2008 and November 2013, 82 @entity7971 procedures were performed on 76 kidneys in 73 @entity1 (mean age 53 years, range: 34-72). All @entity1 had @entity703 and were under dialysis and on the renal transplant waiting list with a temporary contraindication due to excessive renal volume. RESULTS: @entity7971 was considered successful in 89.5% (68/76) of embolized kidneys, meaning that the temporary contraindication for transplantation could be withdrawn for 65 @entity1 (on average 5.6 months, range: 2.8-24.3, after @entity7971 ). Mean volume reduction was 40 (range: 2-69) at 3 months and 59% (35-86) thereafter (both p   <   0.001). @entity887 occurred after 15 of 82 procedures (18.3%). The severe complication rate was 4.9%. Forty-three (67.7%) transplantations were successfully conducted after @entity7971 , with a mean follow-up of 26.2 months (range: 1.8-59.5), and the estimated 5-year graft survival rate was 95.3% [95% CI: 82.7-98.8]. CONCLUSIONS: @entity7971 is a safe and effective alternative to nephrectomy before renal transplantation in @entity1 with @entity8 . KEY POINTS:     Embolization of non-functioning polycystic kidneys allowed transplantation in 89.5% of cases.     Technical failure rate was 7.9% after embolization, irrespective of the technique used.     @entity887 occurred after 18.3% of the procedures.     A low rate of severe complications (4.9%) was observed after renal embolization.

title: Embolization of renal arteries before transplantation in XXXX with @entity8 : a single institution long-term experience.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Recently several authors have reported that diffusion tensor imaging (DTI) might provide a new understanding of sciatica. The purpose of this study was to investigate the clinical feasibility of DTI for the evaluation of lumbar spinal nerve of @entity1 with sciatica associated with @entity179 . Thirty-four @entity1 (25 @entity1 , mean age63. 3years) with @entity528 , 14 @entity1 with @entity2649 with @entity850 , 12 with @entity2649 without @entity850 , five with @entity1643 , and one with spondylolysis who underwent 3.0T magnetic resonance (MR) imaging and surgical treatment were included in the present study. Fractional anisotropy (FA) was calculated from an FA map, and tractography was investigated. In asymptomatic nerves, tractography showed all L3-S1 spinal nerve roots clearly. Abnormalities of tractography were classified into three types by shape; "Disrupted", "Narrowing", and "Tapering". More abnormalities of tractography were found in @entity1 with @entity2649 , and especially in @entity1 with @entity850 . The disrupted type was the most common. The mean FA of entrapped symptomatic nerves was less than seen on the intact side. This study demonstrates that tractography shows abnormal findings for nerve roots in lumbar spinal degeneration and that FA decreases in symptomatic roots. DTI may offer not only morphological evaluation, but also quantitative evaluation. We believe that DTI can be used as a tool for the diagnosis of lumbar @entity179 .

title: Diffusion tensor imaging of lumbar spinal nerve in subjects with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['lumbar disc herniation, two with discogenic low back pain']

entities_list: @entity2649 :: ('MESH:C563613', 'Disease') :: ['lumbar spinal stenosis']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['lumbar degenerative disorders', 'spinal degenerative disease']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['foraminal stenosis']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['degenerated lumbar disease']

answer: @entity179 :: (MESH:D019636,Disease) :: ['degenerative lumbar disorders']


abstract: BACKGROUND: Biomarkers are a promising tool for the management of @entity1 with @entity731 , but their variation is largely unknown. We assessed within-subject and between-subject biological variation of biomarkers in @entity3657 ( @entity3657 ) @entity1 and healthy controls, and defined which biomarkers have a favorable variation profile for future studies. METHODS: Prospective, parallel-group cohort study, including 62 @entity1 with stable @entity3657 (79% @entity1 , 65  7years) and 18 healthy control subjects (44% @entity1 , 57  7years). Blood samples were taken at baseline, and after 3-, 6-, and 12-months. We calculated within-subject (CVI) and between-subject (CVG) coefficients of variation and intra-class correlation coefficient (ICC). RESULTS: Mean levels of D-dimer, hs-CRP, @entity650 , @entity687 , @entity1495 , @entity1549 , @entity38288 , @entity2289 , sICAM-1, and sP-selectin levels were higher in @entity3657 @entity1 than in healthy controls (P <=.05 for all). CVI and CVG of the different biomarkers varied considerably in both groups. An ICC>= 0.5 (indicating moderate-to-good reliability) was found for hs-CRP, D-Dimer, @entity4105 , @entity688 , @entity2842 , @entity1549 , oxLDL, sICAM-1 and sP-selectin in both groups, for sVCAM in healthy controls and for @entity1495 , @entity2289 and sCD40L in @entity3657 @entity1 . CONCLUSIONS: Single biomarker measurements are of limited utility due to large within-subject variation, both in @entity3657 @entity1 and healthy subjects. D-dimer, hs-CRP, @entity1495 , @entity1549 , @entity2289 , sP-selectin and sICAM-1 are biomarkers with both higher mean levels in @entity3657 @entity1 and a favorable variation profile making them most suitable for future studies.

title: Biological variation of established and novel biomarkers for XXXX : Results from a prospective, parallel-group cohort study.

entities_list: @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery disease', 'PAD']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

answer: @entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']


abstract: UNASSIGNED: @entity1 are constantly exposed to airborne Aspergillus spores. Most develop Aspergillus-specific antibodies by adulthood. @entity1 with @entity1030 or Aspergillus airway colonization often have raised levels of Aspergillus-specific immunoglobululin G (IgG). It is not known whether this signifies an increased risk of future @entity2381 . Chronic and allergic forms of @entity57 are estimated to affect over three million people worldwide. Antibody testing is central to diagnosis of these conditions, with raised Aspergillus-specific IgG in chronic @entity57 and raised Aspergillus-specific IgE in @entity56 . Antibody levels are also used to monitor treatment response in these syndromes. Acute @entity3 is less common. There is a more limited role for antibody testing in this setting as immunosuppression often results in delayed or absent antibody response. Many methods exist to detect Aspergillus-specific antibodies, but there are limited published data regarding comparative efficacy and reproducibility. We discuss the comparative merits of the available tests in the various clinical settings and their suitability for use in the resource-poor settings where the majority of cases of @entity2381 are thought to occur. We summarize the gaps in existing knowledge and opportunities for further study that could allow optimal use of antibody testing in this field.

title: Antibody testing in XXXX -quo vadis?

entities_list: @entity1 :: ('9606', 'Species') :: ['Persons', 'Humans']

entities_list: @entity57 :: ('MESH:D055732', 'Disease') :: ['pulmonary aspergillosis']

entities_list: @entity2381 :: ('MESH:D001228', 'Disease') :: ['aspergillosis']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic aspergillosis']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive disease']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic lung disease']

answer: @entity2381 :: (MESH:D001228,Disease) :: ['aspergillosis']


abstract: The present series consists of 18 consecutive @entity1 with @entity977 operated on between 1977 and 1979 using the transfrontal route. Ten @entity652 were 10, 20 or 30 times the normal maximum size of the pituitary measured according to Di Chiro and Nelson's (2) index (Table 2). @entity5 without obvious suprasellar growth were operated on using the trans-sphenoidal route and thus are not included in the present series. Large and @entity977 are preferably removed by the transfrontal route and using microsurgical techniques. Really poor vision associated with @entity5 seem to improve but not to normal level. @entity735 stays blind. @entity227 returns to normal (Table 4). Prolactin values associated with @entity2013 are extremely high and may remain raised even after apparently radical extirpation. @entity5 -containing sellar crypts associated with these large @entity5 may be responsible for this observation. Postoperative radiotherapy and @entity2847 administration therefore seem advisable. Further operations may be necessary on @entity1 with extensive posterior or lateral growths. Redundant partially intraosseous @entity5 fragments may be more easily removed later, possibly owing to the beneficial effects of radiation therapy. It is hoped that large and @entity652 in the future will pass into history, even in the peripheral parts of the world. The trans-sphenoidal approach is always a better solution than the transfrontal approach whenever it can be carried out, but it requires earlier diagnosis.

title: Surgery on XXXX in @entity1 in a subarctic region.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2847 :: ('MESH:D001971', 'Chemical') :: ['bromocriptine']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['Less poor vision']

entities_list: @entity2013 :: ('MESH:D015175', 'Disease') :: ['giant prolactinomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumours', 'Isolated tumour', 'very large tumours', 'tumours', 'tumour']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['A blind eye']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary adenomas', 'giant pituitary adenomas']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['giant adenomas', 'adenomas']

answer: @entity977 :: (MESH:D010911,Disease) :: ['pituitary adenomas']


abstract: The present series consists of 18 consecutive @entity1 with @entity977 operated on between 1977 and 1979 using the transfrontal route. Ten @entity652 were 10, 20 or 30 times the normal maximum size of the pituitary measured according to Di Chiro and Nelson's (2) index (Table 2). @entity5 without obvious suprasellar growth were operated on using the trans-sphenoidal route and thus are not included in the present series. Large and @entity977 are preferably removed by the transfrontal route and using microsurgical techniques. Really poor vision associated with @entity5 seem to improve but not to normal level. @entity735 stays blind. @entity227 returns to normal (Table 4). Prolactin values associated with @entity2013 are extremely high and may remain raised even after apparently radical extirpation. @entity5 -containing sellar crypts associated with these large @entity5 may be responsible for this observation. Postoperative radiotherapy and @entity2847 administration therefore seem advisable. Further operations may be necessary on @entity1 with extensive posterior or lateral growths. Redundant partially intraosseous @entity5 fragments may be more easily removed later, possibly owing to the beneficial effects of radiation therapy. It is hoped that large and @entity652 in the future will pass into history, even in the peripheral parts of the world. The trans-sphenoidal approach is always a better solution than the transfrontal approach whenever it can be carried out, but it requires earlier diagnosis.

title: Surgery on @entity977 in XXXX in a subarctic region.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND:    Throughout Asia, there is an unprecedented link between @entity201 and @entity281 with the @entity8072 Opisthorchis viverrini. Multiple processes, including chronic @entity32 and secretion of parasite proteins into the biliary epithelium, @entity5 . Until now, the mechanism and effects of parasite protein entry into cholangiocytes was unknown. METHODS:    Various microscopy techniques were used to identify O. viverrini extracellular vesicles (EVs) and their internalization by @entity1 cholangiocytes. Using mass spectrometry we characterized the EV proteome and associated changes in cholangiocytes after EV uptake, and we detected EV proteins in bile of infected hamsters and @entity1 . Cholangiocyte proliferation and interleukin 6 (IL-6) secretion was measured to assess the impact of EV internalization. RESULTS:    EVs were identified in fluke culture medium and bile specimens from infected hosts. EVs internalized by cholangiocytes drove cell proliferation and IL-6 secretion and induced changes in protein expression associated with endocytosis, wound repair, and @entity5 . Antibodies to an O. viverrini tetraspanin blocked EV uptake and IL-6 secretion by cholangiocytes. CONCLUSIONS:    This is the first time that EVs from a multicellular pathogen have been identified in host tissues. Our findings imply a role for O. viverrini EVs in pathogenesis and highlight an approach to vaccine development for this @entity5 .

title: Carcinogenic XXXX Secretes Extracellular Vesicles That Promote Cholangiocytes to Adopt a Tumorigenic Phenotype.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['drive infection toward cancer', 'cancer', 'infectious cancer']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity201 :: ('MESH:D018281', 'Disease') :: ['cholangiocarcinoma']

answer: @entity8072 :: (6192,Species) :: ['Liver Fluke']


abstract: BACKGROUND: @entity417 ( @entity417 ) comprise a group of heterogenous @entity74 that are caused by the mutation of various genes involved in @entity1446 biosynthesis, @entity5985 cluster biogenesis, or mitochondrial solute transport or metabolism. However, approximately 40% of @entity1 with CSA have not been found to have pathogenic gene mutations. In this study, we systematically analyzed the mutation profile in 10 Chinese @entity1 with sporadic CSA. FINDINGS: We performed targeted deep sequencing analysis in ten @entity1 with CSA using a panel of 417 genes that included known @entity9472 -related genes. Mitochondrial genomes were analyzed using next-generation sequencing with a mitochondria enrichment kit and the HiSeq2000 sequencing platform. The results were confirmed by Sanger sequencing. The @entity37423 mutation was detected in one @entity1 . @entity5361 mutations were detected in three @entity1 , including three novel mutations. Mitochondrial DNA deletions were detected in two @entity1 . No disease-causing mutations were detected in four @entity1 . CONCLUSION: To our knowledge, the @entity2764 -effective mutation @entity71829 of @entity37423 , the compound heterozygous mutation @entity71830 , @entity71831 , and the homozygous mutation @entity71832 of @entity5361 were found for the first time. Our findings add to the number of reported cases of this rare disease and to the CSA pathogenic mutation database. Our findings expand the phenotypic profile of mitochondrial DNA deletion mutations. This work also demonstrates the application of a @entity1503 assay and targeted capture sequencing for the genetic screening analysis and diagnosis of heterogenous genetic CSA.

title: Mutation analysis of XXXX by targeted capture sequencing.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2764 :: ('MESH:D011736', 'Chemical') :: ['pyridoxine']

entities_list: @entity417 :: ('MESH:D000740', 'Disease') :: ['CSAs', 'Congenital sideroblastic anemias']

entities_list: @entity71830 :: ('p|SUB|W|87|X', 'ProteinMutation') :: ['W87X']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['congenital blood disease']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic diseases']

entities_list: @entity5985 :: ('CHEBI:30408', 'Chemical') :: ['iron-sulfur']

answer: @entity417 :: (MESH:D000740,Disease) :: ['Chinese sporadic congenital sideroblastic anemia']


abstract: BACKGROUND: Cross-talk between synovial fibroblasts (SF) and immune cells is suggested to play a crucial role in @entity32 and chronification of @entity309 ( @entity309 ). The contribution of B cells in this process is poorly defined. METHODS: Here, primary B cells from healthy donors were polyclonally activated and cocultured with SF of non-synovitic origin from @entity1 with @entity571 . RESULTS: In B-SF cocultures the concentrations of @entity650 ( @entity650 ) and @entity687 increased manifold compared with single cultures even under physical separation and remained stable for several days after B-cell removal. Intracellular staining confirmed SF as key producers of @entity650 and @entity687 , and B cells as main producers of @entity5 necrosis factor alpha ( @entity310 ) and @entity1192  . Blocking experiments with a combination of anti- @entity310 -antibodies and @entity19646 significantly reduced SF cytokine production by up to 90%, suggesting that B-cell-derived @entity310 and @entity1192   were crucial mediators of SF activation. Interestingly, B-cell cytokine production, @entity2902 expression and proliferation decreased in cocultures by at least 50%, demonstrating a negative regulatory loop towards the activated B cells. Inhibition of @entity7382 , a crucial component of the @entity5 growth factor    (TGF  ) signalling pathway, partly restored B-cell proliferation, suggesting a contribution of SF-derived TGF   in B-cell suppression. Besides cytokines, B-cell-activated SF also upregulated secretion of matrix metalloproteases such as @entity1549 , thereby acquiring potential tissue destructive properties. This was confirmed by their invasion into @entity1 cartilage in the severe combined @entity465 @entity19 fibroblast invasion model in vivo. CONCLUSIONS: Interaction with activated B cells leads to conversion of non-arthritic SF into SF with a proinflammatory and aggressive @entity309 -like phenotype, thereby suggesting a new, so far unrecognised role for B cells in @entity309 pathogenesis.

title: Activated XXXX B cells induce inflammatory fibroblasts with cartilage-destructive properties and become functionally suppressed in return.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'human']

entities_list: @entity7382 :: ('7046', 'Gene') :: ['activin receptor-like kinase 5']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: To describe probabilities and characteristics of disease flares in @entity1 with @entity4932 ( @entity4932 ) and to identify clinical features associated with an increased risk of flare. METHODS: We studied @entity1 in the Research in @entity625 in Canadian @entity1 emphasizing Outcomes (ReACCh-Out) prospective inception cohort. A flare was defined as a recurrence of disease manifestations after attaining inactive disease and was called significant if it required intensification of treatment. Probability of first flare was calculated with Kaplan-Meier methods, and associated features were identified using Cox regression. RESULTS: 1146 @entity1 were followed up a median of 24   months after attaining inactive disease. We observed 627 first flares (54.7% of @entity1 ) with median active joint count of 1, physician global assessment (PGA) of 12   mm and duration of 27   weeks. Within a year after attaining inactive disease, the probability of flare was 42.5% (95% CI 39% to 46%) for any flare and 26.6% (24% to 30%) for a significant flare. Within a year after stopping treatment, it was 31.7% (28% to 36%) and 25.0% (21% to 29%), respectively. A maximum PGA >30   mm, maximum active joint count >4, rheumatoid factor (RF)-positive @entity625 , antinuclear antibodies (ANA) and receiving disease-modifying antirheumatic drugs (DMARDs) or biological agents before attaining inactive disease were associated with increased risk of flare. Systemic @entity4932 was associated with the lowest risk of flare. CONCLUSIONS: In this real-practice @entity4932 cohort, flares were frequent, usually involved a few swollen joints for an average of 6   months and 60% led to treatment intensification. @entity1 with a severe disease course had an increased risk of flare.

title: The risk and nature of flares in XXXX : results from the ReACCh-Out cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['polyarthritis', 'Arthritis']

entities_list: @entity4932 :: ('MESH:D001171', 'Disease') :: ['JIA', 'juvenile idiopathic arthritis']

answer: @entity4932 :: (MESH:D001171,Disease) :: ['juvenile idiopathic arthritis']