abstract: Effects of @entity5520 on @entity174 healing were prospectively investigated for @entity3604 . Although there were no significant differences in clinical outcomes, the presence of intravertebral cleft was related to the medication use. These results suggest that suspension of @entity5520 use should be considered during the @entity174 healing period. INTRODUCTION: The purpose of this prospective study is to investigate whether @entity5520 -based anti- @entity170 medication affects @entity174 healing and clinical outcomes of conservatively treated @entity3604 ( @entity3604 ). METHODS: A total of 105 @entity1 who were diagnosed with acute @entity3604 were prospectively enrolled. According to their previous medication history, the @entity1 were allocated into group I (n   =   39, no history of @entity5520 use) or group II (n   =   66, history of @entity5520 use). Clinical outcomes were assessed using visual analogue scale (VAS), and @entity717 index (ODI). Radiographic parameters including changes in height loss and kyphotic angle at the index vertebra were measured, and radiographic findings suggesting impaired @entity174 healing such as the intravertebral cleft (IVC) sign and @entity174 instability were evaluated. Univariate and multivariate regression analyses were used to identify related factors. RESULTS: There were no significant differences in the last VAS and ODI between groups. There were also no significant differences in the radiographic parameters. Although the IVC sign was seen more commonly in group II (30.3  %) than in group I (20.5  %), @entity174 instability combined with IVC was noted in the same number of cases. On multiple regression analysis, medication history showed no significant relationship with the clinical parameters. However, the presence of the IVC sign was related to medication history (odds ratio 4.8; 95  % confidence interval [CI] 1.02-22.69). CONCLUSIONS: @entity5520 use does not significantly affect the clinical results during conservative treatment for @entity3604 . However, the occurrence of the IVC sign was related to medication history. Although further studies are needed to verify our findings, these results suggest that suspension of @entity5520 use should be considered during the @entity174 healing period for acute @entity3604 .

title: Does @entity5520 -based anti- XXXX medication affect @entity3604 healing?

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic spinal fractures', 'osteoporotic spinal fracture', 'OSFs']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity5520 :: ('D004164', 'Chemical') :: ['Bisphosphonate', 'bisphosphonate']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry disability']

answer: @entity170 :: (MESH:D010024,Disease) :: ['osteoporosis']


abstract: Effects of @entity5520 on @entity174 healing were prospectively investigated for @entity3604 . Although there were no significant differences in clinical outcomes, the presence of intravertebral cleft was related to the medication use. These results suggest that suspension of @entity5520 use should be considered during the @entity174 healing period. INTRODUCTION: The purpose of this prospective study is to investigate whether @entity5520 -based anti- @entity170 medication affects @entity174 healing and clinical outcomes of conservatively treated @entity3604 ( @entity3604 ). METHODS: A total of 105 @entity1 who were diagnosed with acute @entity3604 were prospectively enrolled. According to their previous medication history, the @entity1 were allocated into group I (n   =   39, no history of @entity5520 use) or group II (n   =   66, history of @entity5520 use). Clinical outcomes were assessed using visual analogue scale (VAS), and @entity717 index (ODI). Radiographic parameters including changes in height loss and kyphotic angle at the index vertebra were measured, and radiographic findings suggesting impaired @entity174 healing such as the intravertebral cleft (IVC) sign and @entity174 instability were evaluated. Univariate and multivariate regression analyses were used to identify related factors. RESULTS: There were no significant differences in the last VAS and ODI between groups. There were also no significant differences in the radiographic parameters. Although the IVC sign was seen more commonly in group II (30.3  %) than in group I (20.5  %), @entity174 instability combined with IVC was noted in the same number of cases. On multiple regression analysis, medication history showed no significant relationship with the clinical parameters. However, the presence of the IVC sign was related to medication history (odds ratio 4.8; 95  % confidence interval [CI] 1.02-22.69). CONCLUSIONS: @entity5520 use does not significantly affect the clinical results during conservative treatment for @entity3604 . However, the occurrence of the IVC sign was related to medication history. Although further studies are needed to verify our findings, these results suggest that suspension of @entity5520 use should be considered during the @entity174 healing period for acute @entity3604 .

title: Does XXXX -based anti- @entity170 medication affect @entity3604 healing?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity5520 :: (D004164,Chemical) :: ['bisphosphonate']


abstract: Effects of @entity5520 on @entity174 healing were prospectively investigated for @entity3604 . Although there were no significant differences in clinical outcomes, the presence of intravertebral cleft was related to the medication use. These results suggest that suspension of @entity5520 use should be considered during the @entity174 healing period. INTRODUCTION: The purpose of this prospective study is to investigate whether @entity5520 -based anti- @entity170 medication affects @entity174 healing and clinical outcomes of conservatively treated @entity3604 ( @entity3604 ). METHODS: A total of 105 @entity1 who were diagnosed with acute @entity3604 were prospectively enrolled. According to their previous medication history, the @entity1 were allocated into group I (n   =   39, no history of @entity5520 use) or group II (n   =   66, history of @entity5520 use). Clinical outcomes were assessed using visual analogue scale (VAS), and @entity717 index (ODI). Radiographic parameters including changes in height loss and kyphotic angle at the index vertebra were measured, and radiographic findings suggesting impaired @entity174 healing such as the intravertebral cleft (IVC) sign and @entity174 instability were evaluated. Univariate and multivariate regression analyses were used to identify related factors. RESULTS: There were no significant differences in the last VAS and ODI between groups. There were also no significant differences in the radiographic parameters. Although the IVC sign was seen more commonly in group II (30.3  %) than in group I (20.5  %), @entity174 instability combined with IVC was noted in the same number of cases. On multiple regression analysis, medication history showed no significant relationship with the clinical parameters. However, the presence of the IVC sign was related to medication history (odds ratio 4.8; 95  % confidence interval [CI] 1.02-22.69). CONCLUSIONS: @entity5520 use does not significantly affect the clinical results during conservative treatment for @entity3604 . However, the occurrence of the IVC sign was related to medication history. Although further studies are needed to verify our findings, these results suggest that suspension of @entity5520 use should be considered during the @entity174 healing period for acute @entity3604 .

title: Does @entity5520 -based anti- @entity170 medication affect XXXX healing?

answer: @entity3604 :: (MESH:D058866,Disease) :: ['osteoporotic spinal fracture']


abstract: Background. @entity64 survivors with @entity2026 experience difficulty associated with their @entity497 . While much has been written about @entity2026 's impacts on partners/family, we lack data regarding the psychosocial adjustment of @entity64 survivors, with a paucity of data from the @entity1 themselves. Methods. Qualitative study of lived experiences of individuals with @entity2026 . Each of the @entity64 survivors with @entity2026 completed 3-4 semistructured interviews. In most cases, @entity1 ' partners jointly participated in interviews, which were transcribed and analyzed using techniques derived from grounded theory. Results. 12 @entity1 were interviewed, with the total of 45 interviews over 18 months. Themes included poststroke changes in @entity1 ' relationships and identities, which were altered across several domains including occupational identity, relationship and family roles, and social identity. While all these domains were impacted by @entity2026 , the impact varied over time. Conclusion. Despite the challenges of interviewing individuals with @entity2026 , we explored @entity2026 's impacts on how individuals experience their identity and develop new identities months and years after @entity64 . This data has important implications for primary care of @entity1 with @entity2026 , including the importance of the long-term primary care relationship in supporting psychosocial adjustment to life after @entity64 .

title: Changes in identity after XXXX : implications for primary care.

entities_list: @entity2026 :: ('MESH:D001037', 'Disease') :: ['aphasia', 'poststroke aphasia']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['aphasic stroke', 'stroke', 'Stroke']

entities_list: @entity497 :: ('MESH:D003147', 'Disease') :: ['communication disorder']

answer: @entity64 :: (MESH:D020521,Disease) :: ['aphasic stroke']


abstract: @entity976 , primarily a @entity5 , is associated with a variety of serious problems due to @entity5 localization. @entity5 during surgery is difficult and total resection can rarely be achieved. Growth of the remaining @entity5 continues and symptoms of @entity428 , further @entity227 and hormonal disturbances reappear. However, conservative operation in conjunction with radical irradiation shows good results as regards @entity5 regression and survival with satisfactory quality of life. Irradiation with 50 Gy on average was performed in 5 out of 6 @entity1 with remaining @entity5 or @entity5 recurrence, and satisfactory results were obtained. In all cases @entity5 size regressed. Endocrine disturbances could be ascertained by the combined LHRH-TRH-insulin test and the clinical picture. In nearly every case there was finally a complete lack of hormones of the @entity2339 . Substitution of various hormones became necessary in all cases. Meticulous surveillance of @entity1 still undergoing developmental maturation is mandatory. All six @entity1 are well and lead a nearly normal life.

title: [ XXXX : experience with combined operative and radiotherapy and problems of hormone substitution (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field loss']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['increased intracranial pressure']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Access to the tumour', 'benign tumour', 'tumour']

entities_list: @entity2339 :: ('MESH:D007029', 'Disease') :: ['pituitary-hypothalamic axis']

entities_list: @entity976 :: ('MESH:D003397', 'Disease') :: ['Craniopharyngioma']

answer: @entity976 :: (MESH:D003397,Disease) :: ['Craniopharyngioma']


abstract: The @entity840 adrenal cortex is grossly composed of two regions: an outer, yellow zone and an inner, brown zone. These zones, which represent 33% and 66% of the total adrenocortical volume, respectively, can be separated by blunt dissection. It has been previously reported that specific @entity3333 and @entity10768 binding proteins are present in the high speed supernatant fraction (cytosol) prepared from the whole adrenal cortex of the @entity840 . However, when cytosol was prepared from the separate outer and inner cortical zones, it was found that the @entity134 -binding proteins were concentrated in the inner zone. This correlated with the level of @entity3333 which was significantly greater in the cytosol of the inner zone where greater than 50% was found to be bound. In contrast, the concentration of @entity701 was 30 times greater in the cytosol of the outer cortical zone and less than 4% was found to be bound. These data suggest that @entity701 is produced primarily in the outer cortical zone, a region which comprises only one-third of the total cortical volume. On the other hand, the coexistence of @entity3333 and its binding protein in the inner cortical zone, a region which comprises two-thirds or the greatest cortical volume, indicates a different functional status for this zone. The exact hormonal control of these two vastly different regions (chromatically, morphologically, and functionally) remains to be determined. It is speculated that the inner cortical zone of the adult @entity840 adrenal is the counterpart of the fetal cortex which did not involute.

title: Functional differences between the outer and inner zones of the XXXX adrenal cortex.

entities_list: @entity3333 :: ('MESH:D011284', 'Chemical') :: ['pregnenolone']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity10768 :: ('MESH:C018370', 'Chemical') :: ['pregnenolone sulfate']

answer: @entity840 :: (10141,Species) :: ['guinea pig']


abstract: The places where a @entity1 lives and attends to school are both major environmental and social determinants of its present and future health status. @entity66 ( @entity66 ) and some of their risk factors among @entity1 and adolescent populations are @entity28 and @entity2299 , so finding the patterns of distribution of these risk factors by gender, type of school, area, and margination level is important to do health intervention focusing in their necessities to prevent diseases at younger ages. Because of that, a cross-sectional study was performed among elementary and junior high school students from public and private schools in six of the seven areas of the metropolitan zone of San Luis Potosi, Mexico. Biochemical @entity2299 indicators ( @entity1674 , total @entity165 , and high-density lipoprotein) and anthropometric data (weight and height) were obtained. Seventeen public schools and five private schools with a total of 383 students were included. More than half of the studied population (53.0  %) had elevated @entity412 levels. A total of 330 students (86.2  %) had normal levels of total @entity165 with a mean value of 141.7  mg/dl, and 202 schoolchildren (52.8  %) had lower than acceptable levels of high-density lipoprotein (HDL) with a mean value of 43.9  mg/dl. There were differences in the levels of high-density protein between the areas and the type of school where they had been studied. Finally, a total of 150 students (39.4  %) had at least one altered lipid value and 103 @entity1 (26.9  %) had two altered values. Several students, despite their young age, showed a high prevalence of risk factors, so it is important to design programs according to their necessities.

title: Socio-Urban Spatial Patterns Associated with XXXX among Schoolchildren in the City of San Luis Potosi, Mexico.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'child']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['NCDs', 'Noncommunicable diseases']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity2299 :: (MESH:D050171,Disease) :: ['Dyslipidemia']


abstract: BACKGROUND: Since @entity7278 ( @entity7278 ) appears to be a risk factor for @entity301 , the aim of the study was to determine the relationship between the size of @entity740 and inflammatory markers (hsCRP, @entity650 , @entity310 ), as well as lipids and lipoproteins ( @entity6511 , @entity1675 , @entity755 level) in blood serum of @entity1 with @entity7278 . METHODS: The @entity1 studied (n   =   43) were divided into groups: @entity1 under 50 and over 50  years of age, and a separate subgroup of the oldest age with the largest size of @entity740 . @entity1675 ( @entity1675 ) above 150  mg/dL and below 150  mg/dL was used as an important criterion for the division of @entity1 into groups. The @entity740 size was measured using the Kodak digital imaging system software. The control group consisted of clinically healthy volunteers (n   =   20) without @entity7278 . Lipids were measured on a Siemens analyzer (Germany), @entity1675 , @entity755 , hsCRP levels were determined by immunonephelometric method, using the Health Care Diagnostic Product (Siemens GmbH, Germany), and @entity650 , @entity310 and LpPLAG7 assay kits (ELISA, R_D Systems) were used. RESULTS: The findings suggested that in @entity1 with @entity7278 and their age increase, the @entity740 size, the concentration of inflammatory markers and @entity6511 mass increased. Correlations between the @entity740 size and @entity6511 mass and between the @entity740 size and TG level in @entity1 with @entity1675 150    <=   mg/dL showed increase TG in atherogenic @entity755 -containing @entity412 -rich lipoprotein and TC in @entity165 -rich lipoprotein. The @entity1 with a low @entity1675 and high @entity6511 level can have a higher risk of odontogenic disease and progression of @entity731 and @entity301 . CONCLUSION: We have found a positive correlation between @entity1675 level and the @entity740 size and a negative correlation between @entity6511 level and the @entity740 size. The results suggest that @entity1675 and @entity6511 in HDL particles have antiinflammatory action and together can limit the @entity740 size in @entity1 with a higher @entity1675 level. The literature data on the distribution of lipoprotein particles in subjects are still insufficient, so this problem requires further studies.

title: Lipids and lipoproteins and inflammatory markers in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity7278 :: ('MESH:D055113', 'Disease') :: ['chronic apical periodontitis', 'CAP']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CAP lesions', 'CAP lesion']

entities_list: @entity1675 :: ('335', 'Gene') :: ['Apolipoprotein AI', 'apoAI']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

answer: @entity7278 :: (MESH:D055113,Disease) :: ['chronic apical periodontitis']


abstract: BACKGROUND: Since @entity7278 ( @entity7278 ) appears to be a risk factor for @entity301 , the aim of the study was to determine the relationship between the size of @entity740 and inflammatory markers (hsCRP, @entity650 , @entity310 ), as well as lipids and lipoproteins ( @entity6511 , @entity1675 , @entity755 level) in blood serum of @entity1 with @entity7278 . METHODS: The @entity1 studied (n   =   43) were divided into groups: @entity1 under 50 and over 50  years of age, and a separate subgroup of the oldest age with the largest size of @entity740 . @entity1675 ( @entity1675 ) above 150  mg/dL and below 150  mg/dL was used as an important criterion for the division of @entity1 into groups. The @entity740 size was measured using the Kodak digital imaging system software. The control group consisted of clinically healthy volunteers (n   =   20) without @entity7278 . Lipids were measured on a Siemens analyzer (Germany), @entity1675 , @entity755 , hsCRP levels were determined by immunonephelometric method, using the Health Care Diagnostic Product (Siemens GmbH, Germany), and @entity650 , @entity310 and LpPLAG7 assay kits (ELISA, R_D Systems) were used. RESULTS: The findings suggested that in @entity1 with @entity7278 and their age increase, the @entity740 size, the concentration of inflammatory markers and @entity6511 mass increased. Correlations between the @entity740 size and @entity6511 mass and between the @entity740 size and TG level in @entity1 with @entity1675 150    <=   mg/dL showed increase TG in atherogenic @entity755 -containing @entity412 -rich lipoprotein and TC in @entity165 -rich lipoprotein. The @entity1 with a low @entity1675 and high @entity6511 level can have a higher risk of odontogenic disease and progression of @entity731 and @entity301 . CONCLUSION: We have found a positive correlation between @entity1675 level and the @entity740 size and a negative correlation between @entity6511 level and the @entity740 size. The results suggest that @entity1675 and @entity6511 in HDL particles have antiinflammatory action and together can limit the @entity740 size in @entity1 with a higher @entity1675 level. The literature data on the distribution of lipoprotein particles in subjects are still insufficient, so this problem requires further studies.

title: Lipids and lipoproteins and inflammatory markers in XXXX with @entity7278 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Background/Aims. The aim of this study is to clarify the differences of @entity16365 and @entity14284 expression, chemokine correlated to intestinal homeostasis, between pediatric and adult @entity31 ( @entity31 ) @entity1 . Methods. Onehundred forty-one @entity1 who underwent proctocolectomy were divided to two groups including childhood-onset @entity31 (CUC, <16 years old, n = 24) and adult-onset @entity31 (AUC,    16 years old, n = 117). A total of 141 @entity406 -fixed, @entity982 -embedded tissue samples of rectum were obtained from these @entity1 . Histological inflammation of rectum in resected specimen was evaluated by using Geboes histological assessment. In immunohistochemistry study, the @entity16365 expression was evaluated by intensity and the stained area, and the @entity14284 expression was evaluated by lymphocytes infiltration pattern. Results. @entity16365 score and @entity14284 positive lymphocytes infiltration pattern were statistically significantly correlated with histological inflammation severity of @entity31 in all @entity1 (P < 0.05). @entity16365 and @entity14284 expression in CUC were statistically significantly higher than that in AUC in all or pathologically severe cases (P < 0.05). Conclusions. @entity16365 and @entity14284 may play a significant role in local damage and pathological changes in @entity31 especially pediatric @entity1 . In the future, our understanding of the differences in CCL- @entity14284 interaction between adults and @entity1 may lead to the pathogenesis of @entity8787 .

title: The Increased Expression of @entity16365 and XXXX in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

answer: @entity14284 :: (1235,Gene) :: ['CCR6']


abstract: Background/Aims. The aim of this study is to clarify the differences of @entity16365 and @entity14284 expression, chemokine correlated to intestinal homeostasis, between pediatric and adult @entity31 ( @entity31 ) @entity1 . Methods. Onehundred forty-one @entity1 who underwent proctocolectomy were divided to two groups including childhood-onset @entity31 (CUC, <16 years old, n = 24) and adult-onset @entity31 (AUC,    16 years old, n = 117). A total of 141 @entity406 -fixed, @entity982 -embedded tissue samples of rectum were obtained from these @entity1 . Histological inflammation of rectum in resected specimen was evaluated by using Geboes histological assessment. In immunohistochemistry study, the @entity16365 expression was evaluated by intensity and the stained area, and the @entity14284 expression was evaluated by lymphocytes infiltration pattern. Results. @entity16365 score and @entity14284 positive lymphocytes infiltration pattern were statistically significantly correlated with histological inflammation severity of @entity31 in all @entity1 (P < 0.05). @entity16365 and @entity14284 expression in CUC were statistically significantly higher than that in AUC in all or pathologically severe cases (P < 0.05). Conclusions. @entity16365 and @entity14284 may play a significant role in local damage and pathological changes in @entity31 especially pediatric @entity1 . In the future, our understanding of the differences in CCL- @entity14284 interaction between adults and @entity1 may lead to the pathogenesis of @entity8787 .

title: The Increased Expression of XXXX and @entity14284 in Rectal Mucosa Correlated to Severe Inflammation in Pediatric Ulcerative Colitis.

answer: @entity16365 :: (6364,Gene) :: ['CCL20']


abstract: @entity4585 ( @entity4585 , @entity4585 , or extramedullary @entity5 ) is an extramedullary mass forming @entity5 composed of myeloid precursor cells. It is usually associated with @entity6961 but very rarely may precede the onset of @entity1778 . Here, we are presenting a rare case of primary vaginal @entity4585 in a geriatric female @entity1 without initial presentation of @entity3052 ( @entity3052 ). A 68-year-old female @entity1 with ECOG Performance Score of 1 presented with pervaginal @entity548 for 20 days. On colposcopic examination, she was found to have mass in the anterior fornix of vagina. A punch biopsy specimen revealed @entity8376 . @entity8116 ( @entity8116 ), @entity3335 ( @entity3335 ), and @entity2467 were strongly positive on IHC (immunohistochemistry). The @entity1 's routine blood investigations were normal including peripheral smear, @entity1132 dehydrogenase, @entity414 , 2D echocardiography, conventional cytogenetics, @entity236 , and biopsy. The @entity1 was given 4 cycles of @entity11508 (Decitex, manufactured by Sun Pharmaceutical Industries Limited, India), 20   mg/m(2) for 5 days at an interval of 28 days. There was a partial response to @entity11508 according to RECIST criteria. As @entity11508 therapy was well tolerated, we are continuing in the same way until disease progression without any complications. The @entity1 is undergoing regular follow-up at our centre.

title: XXXX : a rare case report and review of the literature.

entities_list: @entity3335 :: ('4353', 'Gene') :: ['MPO', 'myeloperoxidase']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm', 'myeloid tumour']

entities_list: @entity8116 :: ('MESH:D007960', 'Disease') :: ['LCA', 'leukocyte common antigen']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

entities_list: @entity11508 :: ('MESH:C014347', 'Chemical') :: ['decitabine']

entities_list: @entity8376 :: ('MESH:D014625', 'Disease') :: ['chloromatous infiltration of the vagina']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow aspiration']

entities_list: @entity4585 :: ('MESH:D023981', 'Disease') :: ['chloroma', 'myeloid sarcoma', 'Myeloid sarcoma', 'granulocytic sarcoma']

entities_list: @entity6961 :: ('MESH:D009196', 'Disease') :: ['myeloproliferative disorders']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

answer: @entity4585 :: (MESH:D023981,Disease) :: ['Primary vaginal myeloid sarcoma']


abstract: @entity344 is extremely rare, with less than 10 cases reported in the literature. We report a case of small bowel dissemination of @entity6656 in a 21-year-old African American male with a history of living in San Joaquin Valley. The @entity1 presented with one week of @entity490 , @entity390 , @entity1353 , intermittent fever, and sweat, and one month of @entity1661 . A chest radiograph revealed complete effusion of left lung. A computed tomography scan of the abdomen showed diffuse small bowel thickening and enhancement, as well as omental and peritoneal nodules, and @entity843 . The coccidioidal complement fixation titer was 1   :   256. The duodenal biopsy revealed many spherules filled with round fungal endospores. Later, blood fungal culture showed positivity for @entity8662 . The final diagnosis is disseminated @entity6656 involving lungs, blood, and duodenum. Despite aggressive antifungal therapy, the @entity1 's clinical situation deteriorated and he succumbed to multisystem organ failure one and half months later. A high index of suspicion for @entity344 should be maintained in @entity1 from an endemic area presenting as @entity1661 and @entity158 .

title: Small bowel dissemination of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal distention']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal coccidioidomycosis', 'Gastrointestinal coccidioidomycosis']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity8662 :: ('5501', 'Species') :: ['Coccidioides immitis']

entities_list: @entity6656 :: ('MESH:D003047', 'Disease') :: ['coccidioidomycosis']

answer: @entity6656 :: (MESH:D003047,Disease) :: ['coccidioidomycosis']


abstract: UNASSIGNED: The incidence and mortality of invasive @entity57 (IPA) are rising, particularly in @entity3124 @entity1 and @entity1 with severe @entity1030 ( @entity1030 ). Noninvasive @entity2381 occurring in these @entity1 requires special attention because of the possibility of developing subsequent IPA, given the poor health and worsened immune state of these @entity1 . We compared the performance of the Platelia galactomannan (GM) enzyme immunoassay in the bronchoalveolar lavage fluid (BALF) and serum. The sensitivity, and specificity of BALF-GM were 85.4% and 62.4%, and those of serum-GM were 67.9% and 93.5% at the cutoff index of 0.5. As the cutoff index increased, the specificity of BALF-GM detection was increased with the detriment of sensitivity. The area under the ROC curves was 0.817 (95% CI: 0.718-0.916) for BALF-GM and 0.819 (95% CI: 0.712-0.926) for serum-GM. The optimal cutoff index was 1.19 for BALF-GM, and the sensitivity and specificity were 67.9% and 89.2%. The BALF-GM assay is more sensitive in detecting @entity57 than serum-GM assay and fungal cultures. However, BALF-GM assay has a high false-positive rate at the cutoff index of 0.5. Hence, the diagnostic cutoff index of the BALF-GM assay should be improved to avoid the overdiagnosis of @entity57 in clinic.

title: The Diagnosis of Invasive and Noninvasive XXXX by Serum and Bronchoalveolar Lavage Fluid Galactomannan Assay.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity57 :: ('MESH:D055732', 'Disease') :: ['pulmonary aspergillosis']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['critically ill']

entities_list: @entity2381 :: ('MESH:D001228', 'Disease') :: ['aspergillosis']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

answer: @entity57 :: (MESH:D055732,Disease) :: ['Pulmonary Aspergillosis']


abstract: UNASSIGNED: A 42-year-old @entity1 presenting with complaints of squint for last 20 years. His visual acuity was 20/400 in right eye (RE) and 20/30 in left eye (LE) with glasses. His refraction was RE -16.75/-2.5 D cycl 180 and LE was -14.5/-1.5 D cycl 180. His axial length was 31.23 mm In RE and 29.72 mm in LE. On examination we found he had RE large @entity5971 with hypotropia measuring 130 pd base out and 40 pd base up in RE. A computerized tomography scan revealed that the superior rectus (SR) was shifted nasally, and lateral rectus (LR) was shifted inferiorly. A RE medial rectus (MR) recession and LR resection with muscle transplantation on the MR was done. A loop myopexy was done to correct the path of the LR and SR. The @entity1 had only 18 pd eso and 20 pd hypo on follow-up after 3 months. Loop myopexy in conjunction with muscle transplantation is a safe and effective procedure for large angle @entity5971 associated with @entity735 .

title: Loop myopexy with true muscle transplantation for very large angle XXXX @entity1 .

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['heavy eye syndrome']

entities_list: @entity5971 :: ('MESH:D004948', 'Disease') :: ['esotropia']

answer: @entity735 :: (MESH:D005124,Disease) :: ['heavy eye syndrome']


abstract: UNASSIGNED: A 42-year-old @entity1 presenting with complaints of squint for last 20 years. His visual acuity was 20/400 in right eye (RE) and 20/30 in left eye (LE) with glasses. His refraction was RE -16.75/-2.5 D cycl 180 and LE was -14.5/-1.5 D cycl 180. His axial length was 31.23 mm In RE and 29.72 mm in LE. On examination we found he had RE large @entity5971 with hypotropia measuring 130 pd base out and 40 pd base up in RE. A computerized tomography scan revealed that the superior rectus (SR) was shifted nasally, and lateral rectus (LR) was shifted inferiorly. A RE medial rectus (MR) recession and LR resection with muscle transplantation on the MR was done. A loop myopexy was done to correct the path of the LR and SR. The @entity1 had only 18 pd eso and 20 pd hypo on follow-up after 3 months. Loop myopexy in conjunction with muscle transplantation is a safe and effective procedure for large angle @entity5971 associated with @entity735 .

title: Loop myopexy with true muscle transplantation for very large angle @entity735 XXXX .

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: UNASSIGNED: The reproductive performance of @entity1707 is one of the main determinants of the profit farmers make from @entity1707 production. This study was undertaken to describe whether periods of high environmental temperature have an effect on the farrowing rate, litter sizes and number of @entity2209 in commercial breeding units in South Africa. Data were collected weekly from four commercial breeding units with good records from December 2010 to August 2012. These data included the number of sows mated, number of sows farrowed and number of piglets born alive, as well as the number of @entity2209 . Note was also taken of whether environmental temperature control mechanisms were employed. Temperature data from weather stations within 100 km of the breeding units were obtained from the South African Weather Service. In all breeding units a decrease in farrowing rate following mating during severe average temperatures (> 30   C) when compared to the farrowing rate following mating during mild average temperatures (< 22   C) was observed. When mating occurred at higher temperatures, the resultant litter size was marginally decreased in the breeding units that did not employ environmental temperature control, but was unaffected in the breeding units that did. In all four breeding units the trend was for the average number of piglets born alive to increase as the environmental temperature around the time of farrowing increased and the trend in three of the four breeding units was for the percentage of @entity2209 per litter to decrease with increased temperature around the time of farrowing. The most significant observation in this study was the trend for farrowing rates to decrease following inseminations during times of high ambient temperatures (> 30   C). Environmental temperature control did not negate this effect, but the breeding units employing the environmental temperature control did show higher average farrowing rates overall.

title: The influence of environmental temperatures on farrowing rates and litter sizes in South African XXXX breeding units.

entities_list: @entity2209 :: ('MESH:D050497', 'Disease') :: ['stillbirths']

answer: @entity1707 :: (9823,Species) :: ['pig']


abstract: BACKGROUND AND PURPOSE: To study the significance of @entity729 as a prognostic marker for acute @entity63 @entity64 @entity1 undergoing revascularization treatment after @entity2500 . METHODS: @entity1 with @entity2500 , who underwent intravenous and/or intra-arterial revascularization treatment, were enrolled. Intracranial @entity729 scores were calculated by counting calcified intracranial arteries among major seven arteries on computed tomographic angiography. @entity1 were divided into high ( @entity15213 ; score >= 3) or low calcification burden (LCB; score <3) groups. Demographic, imaging, and outcome data were compared, and whether @entity15213 is a prognostic factor was evaluated. Grave prognosis was defined as modified Rankin Scale 5-6 for this study. RESULTS: Of 80 enrolled @entity1 , the @entity15213 group comprised 15 @entity1 , who were older, and more commonly had @entity6 than @entity1 in the LCB group. Initial National Institutes of Health @entity64 Scale (NIHSS) scores did not differ ( @entity15213 13.3  2.7 vs. LCB 14.6  3.8) between groups. The final good reperfusion after revascularization treatment (thrombolysis in @entity385 score 2b-3, @entity15213 66.7% vs. LCB 69.2%) was similarly achieved in both groups. However, the @entity15213 group had significantly higher NIHSS scores at discharge (16.0  12.3 vs. 7.9  8.3), and more frequent grave outcome at 3 months (57.1% vs. 22.0%) than the LCB group. @entity15213 was proven as an independent predictor for grave outcome at 3 months when several confounding factors were adjusted (odds ratio 4.135, 95% confidence interval, 1.045-16.359, P=0.043). CONCLUSIONS: Intracranial @entity15213 was associated with grave prognosis in @entity1 who have undergone revascularization for @entity2500 .

title: Cerebral XXXX is an imaging prognostic marker for revascularization treatment of @entity2500 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery (MCA) trunk occlusion', 'acute MCA trunk occlusion']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['artery calcification', 'intracranial artery calcification']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity729 :: (MESH:D061205,Disease) :: ['arterial calcification']


abstract: BACKGROUND AND PURPOSE: To study the significance of @entity729 as a prognostic marker for acute @entity63 @entity64 @entity1 undergoing revascularization treatment after @entity2500 . METHODS: @entity1 with @entity2500 , who underwent intravenous and/or intra-arterial revascularization treatment, were enrolled. Intracranial @entity729 scores were calculated by counting calcified intracranial arteries among major seven arteries on computed tomographic angiography. @entity1 were divided into high ( @entity15213 ; score >= 3) or low calcification burden (LCB; score <3) groups. Demographic, imaging, and outcome data were compared, and whether @entity15213 is a prognostic factor was evaluated. Grave prognosis was defined as modified Rankin Scale 5-6 for this study. RESULTS: Of 80 enrolled @entity1 , the @entity15213 group comprised 15 @entity1 , who were older, and more commonly had @entity6 than @entity1 in the LCB group. Initial National Institutes of Health @entity64 Scale (NIHSS) scores did not differ ( @entity15213 13.3  2.7 vs. LCB 14.6  3.8) between groups. The final good reperfusion after revascularization treatment (thrombolysis in @entity385 score 2b-3, @entity15213 66.7% vs. LCB 69.2%) was similarly achieved in both groups. However, the @entity15213 group had significantly higher NIHSS scores at discharge (16.0  12.3 vs. 7.9  8.3), and more frequent grave outcome at 3 months (57.1% vs. 22.0%) than the LCB group. @entity15213 was proven as an independent predictor for grave outcome at 3 months when several confounding factors were adjusted (odds ratio 4.135, 95% confidence interval, 1.045-16.359, P=0.043). CONCLUSIONS: Intracranial @entity15213 was associated with grave prognosis in @entity1 who have undergone revascularization for @entity2500 .

title: Cerebral @entity729 is an imaging prognostic marker for revascularization treatment of XXXX .

answer: @entity2500 :: (MESH:D020244,Disease) :: ['acute middle cerebral arterial occlusion']


abstract: UNASSIGNED: Endometriosis is a significant risk factor for clear cell and @entity43 and is often found contiguous with these @entity5 . Using whole-genome shotgun sequencing of seven @entity43 ( @entity43 ) and targeted sequencing in synchronous @entity46 , we have investigated how this @entity189 may evolve from @entity46 . In every case we observed multiple @entity5 -associated somatic mutations in at least one concurrent @entity75 . @entity10161 and @entity10160 mutations appeared consistently in concurrent @entity46 when present in the primary @entity43 . In several cases, one or more @entity75 carried the near-complete complement of somatic mutations present in the index @entity43 . Ancestral mutations were detected in both @entity5 -adjacent and -distant @entity75 , regardless of any cytological atypia. These findings provide objective evidence that multifocal benign @entity75 are clonally related and that CCCs arising in these @entity1 progress from @entity75 that may already carry sufficient @entity5 -associated mutations to be considered @entity5 themselves, albeit with low malignant potential. We speculate that genomically distinct classes of @entity46 exist and that @entity43 with high mutational burden represents one class at high risk for malignant transformation.    2015 The Authors. The Journal of Pathology published by John Wiley _ Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

title: Multifocal @entity75 associated with XXXX are clonal and carry a high mutation burden.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['endometrioid ovarian cancers', 'ovarian endometriosis', 'CCC', 'CCC tumour', 'clear cell ovarian carcinomas']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['endometriotic lesion', 'endometriotic lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'neoplasms', 'tumour']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: UNASSIGNED: Endometriosis is a significant risk factor for clear cell and @entity43 and is often found contiguous with these @entity5 . Using whole-genome shotgun sequencing of seven @entity43 ( @entity43 ) and targeted sequencing in synchronous @entity46 , we have investigated how this @entity189 may evolve from @entity46 . In every case we observed multiple @entity5 -associated somatic mutations in at least one concurrent @entity75 . @entity10161 and @entity10160 mutations appeared consistently in concurrent @entity46 when present in the primary @entity43 . In several cases, one or more @entity75 carried the near-complete complement of somatic mutations present in the index @entity43 . Ancestral mutations were detected in both @entity5 -adjacent and -distant @entity75 , regardless of any cytological atypia. These findings provide objective evidence that multifocal benign @entity75 are clonally related and that CCCs arising in these @entity1 progress from @entity75 that may already carry sufficient @entity5 -associated mutations to be considered @entity5 themselves, albeit with low malignant potential. We speculate that genomically distinct classes of @entity46 exist and that @entity43 with high mutational burden represents one class at high risk for malignant transformation.    2015 The Authors. The Journal of Pathology published by John Wiley _ Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

title: Multifocal XXXX associated with @entity5 are clonal and carry a high mutation burden.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity75 :: (MESH:D001927,Disease) :: ['endometriotic lesions']


abstract: Two groups of @entity35 received @entity2379 (Amp). One group (AA) received a single acute dose of 1 mg/kg i.v. The second (CA) received 10 mg/kg i.p. daily for 4 days. In AA @entity35 , measurements 1 to 5 hr after Amp were compared with their own preinfusion values. Inulin clearance, (CIn, 4.5 ml X min-1 X kg-1 per kidney pre vs. 1.3 post), @entity8 ( @entity8 , 12.0 ml X min-1 X kg-1 vs. 7.4), and the estimated pressure in the glomerular capillaries ( @entity2481 , 52 mm Hg vs. 40), were all significantly decreased while renal vascular resistance (5.2 mm Hg/ml vs. 12.0) was increased. Only 45% of the 3H-inulin injected into surface tubules was recovered in the urine as contrasted with 100% recovery before injection. This suggests that tubule permeability was increased, but there was no histologic evidence of @entity9538 . Twenty-four hours after intravenous Amp, CIn and @entity8 returned to normal. Data from CA @entity35 were compared with values from sham-treated pairfed (PF) control @entity35 . Again, CIn (4.22 ml X min-1 X kg-1 in PF vs. 2.69 in CA), @entity8 (16.1 ml X min-1 X kg-1 vs. 8.3), and @entity2481 (48 mm Hg vs. 38) were decreased, and renal vascular resistance (4.9 mm Hg/ml vs. 8.0) was increased. The recovery of 3H-inulin in the urine was slightly, but significantly, decreased (96% vs. 83%). These findings demonstrate that Amp decreases renal function by at least two mechanisms. An increase in renal vascular resistance is most important, although increased tubule permeability with a "backleak" of tubule fluid also contributes to @entity8 , particularly after intravenous Amp.

title: XXXX nephrotoxicity: increased renal resistance and tubule permeability.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal plasma flow', 'RPF', 'renal dysfunction']

entities_list: @entity9538 :: ('MESH:D007673', 'Disease') :: ['renal tubule necrosis']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin-B']

answer: @entity2379 :: (MESH:D000666,Chemical) :: ['Amphotericin B']


abstract: PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) imaging characteristics of @entity99 in @entity1 with normal, fibrotic and cirrhotic livers. MATERIALS AND METHODS: Retrospective, institutional review board approved study (waiver of informed consent). Eighty-nine consecutive @entity1 with 231 @entity99 who underwent liver MR imaging for lesion characterization were included. Lesions were classified into three groups according to the @entity1 ' liver condition: no underlying @entity409 (group 1), @entity82 (group 2) and @entity82 (group 3). Qualitative and quantitative characteristics (number, size, signal intensities on T1-, T2-, and DW MR images, T2 shine-through effect, enhancement patterns (classical, rapidly filling, delayed filling), and ADC values) were compared. RESULTS: There were 160 (69%), 45 (20%), and 26 (11%) @entity2695 in groups 1, 2 and 3, respectively. Lesions were larger in @entity1 with normal liver (group 1 vs. groups 2 and 3; P=.009). No difference was found between the groups on T2-weighted images (fat-suppressed fast spin-echo (P=.82) and single-shot (P=.25)) and in enhancement patterns (P=.56). Mean ADC values of @entity2695 were similar between groups 1, 2 and 3 (2.11  .52*10(-3)mm(2)/s, 2.1  .53*10(-3)mm(2)/s and 2.14  .44*10(-3)mm(2)/s, P=87, respectively). T2 shine-through effect was less frequently observed in @entity82 (P=.02). CONCLUSION: MR imaging characteristics of @entity99 were similar in @entity1 with normal compared to fibrotic and cirrhotic livers. Smaller lesion size was observed with @entity409 and less T2 shine-through effect was seen in @entity2695 developed on @entity82 , the latter being an important finding to highlight in these @entity1 at risk of developing @entity157 .

title: Is magnetic resonance imaging of XXXX any different in liver @entity82 and @entity82 compared to normal liver?

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis', 'cirrhosis']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangiomas']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic hemangiomas', 'hepatic hemangioma']

answer: @entity99 :: (MESH:D056486,Disease) :: ['hepatic hemangioma']


abstract: PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) imaging characteristics of @entity99 in @entity1 with normal, fibrotic and cirrhotic livers. MATERIALS AND METHODS: Retrospective, institutional review board approved study (waiver of informed consent). Eighty-nine consecutive @entity1 with 231 @entity99 who underwent liver MR imaging for lesion characterization were included. Lesions were classified into three groups according to the @entity1 ' liver condition: no underlying @entity409 (group 1), @entity82 (group 2) and @entity82 (group 3). Qualitative and quantitative characteristics (number, size, signal intensities on T1-, T2-, and DW MR images, T2 shine-through effect, enhancement patterns (classical, rapidly filling, delayed filling), and ADC values) were compared. RESULTS: There were 160 (69%), 45 (20%), and 26 (11%) @entity2695 in groups 1, 2 and 3, respectively. Lesions were larger in @entity1 with normal liver (group 1 vs. groups 2 and 3; P=.009). No difference was found between the groups on T2-weighted images (fat-suppressed fast spin-echo (P=.82) and single-shot (P=.25)) and in enhancement patterns (P=.56). Mean ADC values of @entity2695 were similar between groups 1, 2 and 3 (2.11  .52*10(-3)mm(2)/s, 2.1  .53*10(-3)mm(2)/s and 2.14  .44*10(-3)mm(2)/s, P=87, respectively). T2 shine-through effect was less frequently observed in @entity82 (P=.02). CONCLUSION: MR imaging characteristics of @entity99 were similar in @entity1 with normal compared to fibrotic and cirrhotic livers. Smaller lesion size was observed with @entity409 and less T2 shine-through effect was seen in @entity2695 developed on @entity82 , the latter being an important finding to highlight in these @entity1 at risk of developing @entity157 .

title: Is magnetic resonance imaging of @entity99 any different in liver XXXX and @entity82 compared to normal liver?

answer: @entity82 :: (MESH:D005355,Disease) :: ['fibrosis']


abstract: PURPOSE: To compare qualitative and quantitative magnetic resonance (MR) imaging characteristics of @entity99 in @entity1 with normal, fibrotic and cirrhotic livers. MATERIALS AND METHODS: Retrospective, institutional review board approved study (waiver of informed consent). Eighty-nine consecutive @entity1 with 231 @entity99 who underwent liver MR imaging for lesion characterization were included. Lesions were classified into three groups according to the @entity1 ' liver condition: no underlying @entity409 (group 1), @entity82 (group 2) and @entity82 (group 3). Qualitative and quantitative characteristics (number, size, signal intensities on T1-, T2-, and DW MR images, T2 shine-through effect, enhancement patterns (classical, rapidly filling, delayed filling), and ADC values) were compared. RESULTS: There were 160 (69%), 45 (20%), and 26 (11%) @entity2695 in groups 1, 2 and 3, respectively. Lesions were larger in @entity1 with normal liver (group 1 vs. groups 2 and 3; P=.009). No difference was found between the groups on T2-weighted images (fat-suppressed fast spin-echo (P=.82) and single-shot (P=.25)) and in enhancement patterns (P=.56). Mean ADC values of @entity2695 were similar between groups 1, 2 and 3 (2.11  .52*10(-3)mm(2)/s, 2.1  .53*10(-3)mm(2)/s and 2.14  .44*10(-3)mm(2)/s, P=87, respectively). T2 shine-through effect was less frequently observed in @entity82 (P=.02). CONCLUSION: MR imaging characteristics of @entity99 were similar in @entity1 with normal compared to fibrotic and cirrhotic livers. Smaller lesion size was observed with @entity409 and less T2 shine-through effect was seen in @entity2695 developed on @entity82 , the latter being an important finding to highlight in these @entity1 at risk of developing @entity157 .

title: Is magnetic resonance imaging of @entity99 any different in liver @entity82 and XXXX compared to normal liver?

answer: @entity82 :: (MESH:D005355,Disease) :: ['cirrhosis']


abstract: BACKGROUND: Eosinophilic @entity2883 with @entity2883 (EGPA) is a rare @entity13571 associated with @entity565 , @entity1712 , and @entity1333 . EGPA is potentially life-threatening and often involves @entity1897 , peptic ulcers, @entity6249 , and @entity65 . However, there is limited understanding of the prognostics factors for @entity1 with EGPA. We investigated the clinical features and factors affecting @entity1 ' in-hospital mortality, using a national inpatient database in Japan. METHODS: We retrospectively collected data of EGPA @entity1 who required hospitalization between July 2010 and March 2013, using the Diagnosis Procedure Combination database. We evaluated EGPA @entity1 ' characteristics and performed multivariate logistic regression analyses to assess the factors associated with in-hospital mortality. RESULTS: A total of 2195 EGPA @entity1 were identified. The mean age was 61.9  years, 42.1% (924/2195) were male, and 41.6% (914/2195) had emergent admission. In-hospital deaths occurred in 97/2195 @entity1 (4.4%). Higher in-hospital mortality was associated with age older than 65  years, disturbance of consciousness on admission, unscheduled admission, @entity1576 , @entity66 , @entity8 , @entity295 , and @entity5 on admission. Lower mortality was associated with female gender and @entity1897 . CONCLUSIONS: Our study revealed the clinical features of EGPA @entity1 who required hospitalization and the factors associated with their mortality. These results may be useful for physicians when assessing disease severity or treatments for hospitalized EGPA @entity1 .

title: Factors that predict in-hospital mortality in eosinophilic XXXX with @entity2883 .

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease']

entities_list: @entity13571 :: ('MESH:D056647', 'Disease') :: ['systemic small-vessel vasculitis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cardio-cerebrovascular disease']

entities_list: @entity6249 :: ('MESH:D059345', 'Disease') :: ['cerebral vessel disease']

entities_list: @entity1333 :: ('MESH:D014657', 'Disease') :: ['necrotizing vasculitis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant disease']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathies']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory disease']

entities_list: @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity2883 :: (MESH:D014890,Disease) :: ['granulomatosis']


abstract: BACKGROUND: Eosinophilic @entity2883 with @entity2883 (EGPA) is a rare @entity13571 associated with @entity565 , @entity1712 , and @entity1333 . EGPA is potentially life-threatening and often involves @entity1897 , peptic ulcers, @entity6249 , and @entity65 . However, there is limited understanding of the prognostics factors for @entity1 with EGPA. We investigated the clinical features and factors affecting @entity1 ' in-hospital mortality, using a national inpatient database in Japan. METHODS: We retrospectively collected data of EGPA @entity1 who required hospitalization between July 2010 and March 2013, using the Diagnosis Procedure Combination database. We evaluated EGPA @entity1 ' characteristics and performed multivariate logistic regression analyses to assess the factors associated with in-hospital mortality. RESULTS: A total of 2195 EGPA @entity1 were identified. The mean age was 61.9  years, 42.1% (924/2195) were male, and 41.6% (914/2195) had emergent admission. In-hospital deaths occurred in 97/2195 @entity1 (4.4%). Higher in-hospital mortality was associated with age older than 65  years, disturbance of consciousness on admission, unscheduled admission, @entity1576 , @entity66 , @entity8 , @entity295 , and @entity5 on admission. Lower mortality was associated with female gender and @entity1897 . CONCLUSIONS: Our study revealed the clinical features of EGPA @entity1 who required hospitalization and the factors associated with their mortality. These results may be useful for physicians when assessing disease severity or treatments for hospitalized EGPA @entity1 .

title: Factors that predict in-hospital mortality in eosinophilic @entity2883 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity2883 :: (MESH:D014890,Disease) :: ['polyangiitis']


abstract: PURPOSE: To quantitatively analyze @entity2840 ( @entity2840 ) in @entity1 with primary @entity2747 (PACG) and @entity725 ( @entity725 ), and to evaluate its correlation with severity of @entity726 . METHODS: In this retrospective study, records of @entity1 with previously diagnosed @entity725 or PACG at a tertiary @entity726 service were reviewed. @entity2840 was measured by ultrasound pachymetry. @entity5494 ( @entity5494 ) on @entity227 ( @entity227 ) testing was recorded for @entity726 severity determination. @entity2840 and age- and sex-adjusted @entity2840 were compared among the study groups using Student's t-test and analysis of covariance (ANCOVA), respectively. Univariate and multivariate regression models were used for correlation of age, @entity5494 and @entity2840 . RESULTS: A total of 115 @entity1 with PACG, 215 with @entity725 , and 100 normal controls were included with mean age of 64.1    10.4, 59.9    10.5, and 62.04    10.80 years, respectively. @entity2840 was thicker in PACG eyes (545.5    46.1  m) as compared to @entity725 eyes (531.7    37.3  m) and controls (531.0    38.3  m) even after age and gender adjustment (ANCOVA, P = 0.05). @entity2840 was found to decrease with increasing age only in the @entity725 group (b = -0.57, P = 0.01). Disease severity ( @entity5494 of @entity227 ) was significantly and inversely correlated with @entity2840 in both @entity725 and PACG eyes (b = 1.89, P = 0.02; and b = 1.38, P = 0.04, respectively) after age and sex correction. CONCLUSION: PACG eyes had thicker @entity2840 as compared to @entity725 and normal healthy eyes in Iranian subjects. Severity of the disease was inversely correlated with @entity2840 in eyes with both @entity725 and PACG.

title: Central corneal thickness in primary angle closure and open XXXX .

entities_list: @entity725 :: ('MESH:C562750', 'Disease') :: ['primary open-angle glaucoma', 'POAG']

entities_list: @entity2840 :: ('MESH:C563262', 'Disease') :: ['central corneal thickness', 'CCT']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field', 'VF']

entities_list: @entity5494 :: ('MESH:D010262', 'Disease') :: ['Mean deviation', 'MD']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity2747 :: ('MESH:D015812', 'Disease') :: ['angle closure glaucoma']

answer: @entity726 :: (MESH:D005901,Disease) :: ['angle glaucoma']


abstract: BACKGROUND: India is currently suffering from an epidemic of noncommunicable diseases; it is thus imperative to screen for cardiovascular risk factors in @entity1 visiting Primary Health Centers (PHCs). The objective of the study was to measure the amount of undiagnosed @entity101 and selected cardiovascular risk factors present among the adult population through opportunistic screening at the PHC. METHODS: A facility-based opportunistic screening program was carried out in a PHC in rural Puducherry. @entity1 and accompanying @entity1 aged 30 years and above, who attended the daily outpatient department (OPD) were included. The OPD provides outpatient services and medical procedures or tests without requirement of an overnight stay, and functions for 4 h a day. Known @entity101 @entity1 and pregnant @entity1 were excluded. Information on age, gender, @entity6 status, and personal history of @entity286 and alcohol use were collected using an interview schedule. Height, weight and waist circumference were measured, along with blood pressure and blood sugar using standard protocols. Systolic blood pressure (SBP) >= 140 and/or diastolic blood pressure (DBP) >= 90 mm Hg was taken as @entity101 . SBP of 120-139 mm Hg and/or DBP of 80-89 mm Hg were taken as @entity1556 . RESULTS: A total of 324 @entity1 were screened; 56.8% were females. The mean standard deviation (SD) age of the @entity1 was 47.7 (SD 12.6) years. @entity101 and @entity1556 were present in 17.9% and 37.7% of the @entity1 respectively. 17.3% @entity1 had @entity6 . 22.2% and 21.3% of all @entity1 were current users of @entity286 and alcohol respectively. Generalized @entity28 was present in 31.8% of the @entity1 ; 19.1% were overweight. 45.1% @entity1 had @entity1144 . CONCLUSIONS: A relatively large proportion of adults were found to have @entity1556 and @entity28 , thus showing the need for early intervention.

title: Opportunistic Screening for XXXX and Selected Cardiovascular Risk Factors among Adults Attending a Primary Health Center in Puducherry, India.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Patients', 'patients', 'people', 'persons']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive', 'Hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity1144 :: ('MESH:D056128', 'Disease') :: ['central obesity']

entities_list: @entity1556 :: ('MESH:D058246', 'Disease') :: ['prehypertension']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertension']


abstract: The purpose was to test the hypothesis that the magnitude of the reduction in peak @entity26 uptake (VO2) after bed rest is directly proportional to the level of pre-bed rest peak VO2. Complete pre- and post-bed rest working capacity and body weight data were available from three studies involving 24 @entity1 (19-24 yr; peak VO2, 2.39-4.80 l . @entity1009 ) and 8 @entity1 (23-34 yr; peak VO2 1.47-2.58 l . @entity1009 ), who underwent bed rest for 14-20 d with no remedial treatments. Regression analysis of percent change in post-bed rest peak VO2 on pre-bed rest peak VO2 with 32 subjects resulted in correlation coefficients (r) of--0.03 (NS) for data expressed in l . @entity1009 (NS) for data expressed in ml . @entity1009 . kg-1. Significant correlations were found that supported the hypothesis only when peak VO2 data were analyzed separately from studies that utilized the cycle ergometer, particularly with subjects in the supine position, as opposed to data obtained from treadmill peak VO2 tests. We conclude that orthostatic factors, associated with the upright body position and relatively high levels of physical fitness from endurance training, appear to increase variability of pre- and particularly post-bed rest peak VO2 data, which would lead to rejection of the hypothesis.

title: Reduction in peak XXXX uptake after prolonged bed rest.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: AIM: To systematically compare the efficacy and safety of off-label bevacizumab versus licensed ranibizumab intravitreal injections as well as monthly regimen versus pro re nata [PRN (as needed)] regimen in the treatment of neovascular age-related @entity1020 (nAMD). METHODS: Relevant publications were identified through automatically retrieve of database and manually retrieving. The methodological quality of studies included was assessed using the Jadad score and the risk-of-bias assessment. The efficacy estimates were measured by the @entity353 ( @entity353 ) for the improvement of best-corrected visual acuity (BCVA) and central @entity989 . The safety estimates were measured by odds ratios (OR) for adverse events rates. Statistical analysis was conducted by Revman 5.2.7. RESULTS: Seven studies were included in the Meta-analysis. There were no statistically significant differences between bevacizumab and ranibizumab in BCVA at 1 and 2y (P=0.37, P=0.18, respectively), However, both drugs has better BCVA given monthly than given as needed at 1 and 2y (P<0.05). The results demonstrated the mean decrease in CRT was less in bevacizumab group than ranibizumab group at 1y (P<0.05), while the difference was not significant at 2y (P=0.24). Treatment monthly gained much more decrease in CRT at 1 and 2y (P<0.005). There were no differences between drugs in the rates of @entity204 , arterial @entity715 events and venous @entity715 events (P=0.41, P=0.55, P=0.10, respectively), while the rates of medical dictionary for regulatory activities (MedDAR) system organ class events and >= 1 systemic serious adverse events were higher in bevacizumab group than ranibizumab group (P<0.05). But the incidences of @entity204 , arterial @entity715 events, venous @entity715 events, MedDAR system organ class events as well as >= 1 systemic serious adverse events were not statistically different between both treatment regimens of monthly and as needed (P=0.14, P=0.76, P=0.73, P=0.12, P=0.11, respectively). CONCLUSION: Bevacizumab was equivalent to ranibizumab for BCVA, however bevacizumab tended to gain less decrease in CRT and had higher rates of serious adverse events. Compared with treatment as needed, treatment monthly showed superior efficacy in BCVA improvement and CRT reduction, while the rates of adverse events were similar in the two dosing regimens.

title: Bevacizumab versus ranibizumab for neovascular age-related XXXX : a Meta-analysis.

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['WMD', 'weight mean difference']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal thickness (CRT) reduction']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['macular degeneration']

answer: @entity1020 :: (MESH:D008268,Disease) :: ['macular degeneration']


abstract: The relationship between dairy consumption and @entity2690 resistance was ascertained in 272 middle-aged, nondiabetic @entity1 using a cross-sectional design. @entity1 kept 7-day, weighed food records to report their diets, including dairy intake. @entity2690 resistance was assessed using the homeostatic model assessment (HOMA). The Bod Pod was used to measure body fat percentage, and accelerometry for 7 days was used to objectively index physical activity. Regression analysis was used to determine the extent to which mean HOMA levels differed across low, moderate, and high dairy intake categories. Results showed that @entity1 in the highest quartile of dairy consumption had significantly greater log-transformed HOMA values (0.41    0.53) than those in the middle-two quartiles (0.22    0.55) or the lowest quartile (0.19    0.58) (F = 6.90, P = 0.0091). The association remained significant after controlling for each potential confounder individually and all covariates simultaneously. Adjusting for differences in energy intake weakened the relationship most, but the association remained significant. Of the 11 potential confounders, only protein intake differed significantly across the dairy categories, with those consuming high dairy also consuming more total protein than their counterparts. Apparently, high dairy intake is a significant predictor of @entity2690 resistance in middle-aged, nondiabetic @entity1 .

title: Dairy consumption and XXXX resistance: the role of body fat, physical activity, and energy intake.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants', 'women']

answer: @entity2690 :: (3630,Gene) :: ['insulin']


abstract: OBJECTIVE: Effects of the long-term use of antiepileptic drugs (AEDs) on the brains of @entity1 with @entity302 have been previously reported. The aim of this study was to determine the rapid @entity75 induced by single-dose intravenous AED administration that rules out the potential effects of @entity302 . METHODS: Ten @entity2608 were randomly divided into two groups and were intravenously administered a single dose of @entity1092 (VPA) or @entity4677 (LEV) at treatment dosages. Magnetic resonance imaging (MRI) data were recorded from every subject prior to AED administration and at 2h and 1 week after administration. Using optimized voxel-based morphometry (VBM) analysis, we measured changes in regional gray matter volume (GMV) and white matter volume (WMV) in each group over time following medication and directly compared the differences between the two groups. RESULTS: Both AEDs induced brain volume alterations at 2h after their administration, but these changes had reverted at 1 week. The VPA group exhibited increased GMV in the right geniculate nucleus and the right pulvinar, whereas the LEV group exhibited WMV reductions in the right pulvinar, the right parietal lobe and the right occipital lobe. Directly compared with the LEV group, the VPA group exhibited a temporally constant GMV increase in the bilateral temporal cortex and a WMV reduction in the left pedunculus cerebri. CONCLUSIONS: Single-dose intravenous administration of a level of VPA or LEV that mimics clinical use is associated with rapid and reversible VBM-detected GMV or WMV alterations in @entity2608 . This finding may provide new insights into the understanding of AED-induced @entity75 and may contribute to our understanding of the brain-level mechanisms and targets of AED action.

title: Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of XXXX and @entity4677 in @entity2608 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4677 :: ('MESH:C026098', 'Chemical') :: ['levetiracetam']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain structure remodeling']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproic acid']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity2608 :: ('9544', 'Species') :: ['rhesus monkeys']

answer: @entity1092 :: (MESH:D014635,Chemical) :: ['valproate']


abstract: OBJECTIVE: Effects of the long-term use of antiepileptic drugs (AEDs) on the brains of @entity1 with @entity302 have been previously reported. The aim of this study was to determine the rapid @entity75 induced by single-dose intravenous AED administration that rules out the potential effects of @entity302 . METHODS: Ten @entity2608 were randomly divided into two groups and were intravenously administered a single dose of @entity1092 (VPA) or @entity4677 (LEV) at treatment dosages. Magnetic resonance imaging (MRI) data were recorded from every subject prior to AED administration and at 2h and 1 week after administration. Using optimized voxel-based morphometry (VBM) analysis, we measured changes in regional gray matter volume (GMV) and white matter volume (WMV) in each group over time following medication and directly compared the differences between the two groups. RESULTS: Both AEDs induced brain volume alterations at 2h after their administration, but these changes had reverted at 1 week. The VPA group exhibited increased GMV in the right geniculate nucleus and the right pulvinar, whereas the LEV group exhibited WMV reductions in the right pulvinar, the right parietal lobe and the right occipital lobe. Directly compared with the LEV group, the VPA group exhibited a temporally constant GMV increase in the bilateral temporal cortex and a WMV reduction in the left pedunculus cerebri. CONCLUSIONS: Single-dose intravenous administration of a level of VPA or LEV that mimics clinical use is associated with rapid and reversible VBM-detected GMV or WMV alterations in @entity2608 . This finding may provide new insights into the understanding of AED-induced @entity75 and may contribute to our understanding of the brain-level mechanisms and targets of AED action.

title: Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of @entity1092 and XXXX in @entity2608 .

answer: @entity4677 :: (MESH:C026098,Chemical) :: ['levetiracetam']


abstract: OBJECTIVE: Effects of the long-term use of antiepileptic drugs (AEDs) on the brains of @entity1 with @entity302 have been previously reported. The aim of this study was to determine the rapid @entity75 induced by single-dose intravenous AED administration that rules out the potential effects of @entity302 . METHODS: Ten @entity2608 were randomly divided into two groups and were intravenously administered a single dose of @entity1092 (VPA) or @entity4677 (LEV) at treatment dosages. Magnetic resonance imaging (MRI) data were recorded from every subject prior to AED administration and at 2h and 1 week after administration. Using optimized voxel-based morphometry (VBM) analysis, we measured changes in regional gray matter volume (GMV) and white matter volume (WMV) in each group over time following medication and directly compared the differences between the two groups. RESULTS: Both AEDs induced brain volume alterations at 2h after their administration, but these changes had reverted at 1 week. The VPA group exhibited increased GMV in the right geniculate nucleus and the right pulvinar, whereas the LEV group exhibited WMV reductions in the right pulvinar, the right parietal lobe and the right occipital lobe. Directly compared with the LEV group, the VPA group exhibited a temporally constant GMV increase in the bilateral temporal cortex and a WMV reduction in the left pedunculus cerebri. CONCLUSIONS: Single-dose intravenous administration of a level of VPA or LEV that mimics clinical use is associated with rapid and reversible VBM-detected GMV or WMV alterations in @entity2608 . This finding may provide new insights into the understanding of AED-induced @entity75 and may contribute to our understanding of the brain-level mechanisms and targets of AED action.

title: Single-dose intravenous administration of antiepileptic drugs induces rapid and reversible remodeling in the brain: Evidence from a voxel-based morphometry evaluation of @entity1092 and @entity4677 in XXXX .

answer: @entity2608 :: (9544,Species) :: ['rhesus monkeys']


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity616 ( @entity616 ) for @entity158 control in @entity1 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity1 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity1 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity5403 - @entity3303 cream application, (3) @entity616 and (4) @entity616 + intrarectal @entity5403 - @entity3303 cream application (combined group). @entity1 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity158 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity616 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity616 , @entity5403 - @entity3303 cream and combined groups compared to the control group (P < .001). In addition, the @entity616 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity616 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity616 alone seemed to be superior to @entity5403 - @entity3303 cream application in @entity1 undergoing prostate biopsy. Addition of @entity5403 - @entity3303 cream application to @entity616 may not provide better analgesia._

title: Novel Approach for @entity158 Control in @entity1 Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of @entity5403 - XXXX : A Randomized Controlled Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5403 :: ('MESH:D011318', 'Chemical') :: ['prilocaine']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['INB', 'iliohypogastric nerve block']

answer: @entity3303 :: (MESH:D008012,Chemical) :: ['Lidocaine']


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity616 ( @entity616 ) for @entity158 control in @entity1 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity1 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity1 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity5403 - @entity3303 cream application, (3) @entity616 and (4) @entity616 + intrarectal @entity5403 - @entity3303 cream application (combined group). @entity1 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity158 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity616 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity616 , @entity5403 - @entity3303 cream and combined groups compared to the control group (P < .001). In addition, the @entity616 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity616 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity616 alone seemed to be superior to @entity5403 - @entity3303 cream application in @entity1 undergoing prostate biopsy. Addition of @entity5403 - @entity3303 cream application to @entity616 may not provide better analgesia._

title: Novel Approach for @entity158 Control in @entity1 Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of XXXX - @entity3303 : A Randomized Controlled Trial.

answer: @entity5403 :: (MESH:D011318,Chemical) :: ['Prilocaine']


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity616 ( @entity616 ) for @entity158 control in @entity1 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity1 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity1 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity5403 - @entity3303 cream application, (3) @entity616 and (4) @entity616 + intrarectal @entity5403 - @entity3303 cream application (combined group). @entity1 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity158 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity616 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity616 , @entity5403 - @entity3303 cream and combined groups compared to the control group (P < .001). In addition, the @entity616 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity616 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity616 alone seemed to be superior to @entity5403 - @entity3303 cream application in @entity1 undergoing prostate biopsy. Addition of @entity5403 - @entity3303 cream application to @entity616 may not provide better analgesia._

title: Novel Approach for XXXX Control in @entity1 Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of @entity5403 - @entity3303 : A Randomized Controlled Trial.

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: PURPOSE: To investigate the efficacy of a novel anesthetic technique called @entity616 ( @entity616 ) for @entity158 control in @entity1 undergoing prostate biopsy. MATERIALS AND METHODS: A total of 59 consecutive @entity1 who underwent transrectal ultrasound guided prostates biopsies were included in the study. @entity1 were randomized into four groups: (1) control, no method of anesthesia was administered, (2) intrarectal @entity5403 - @entity3303 cream application, (3) @entity616 and (4) @entity616 + intrarectal @entity5403 - @entity3303 cream application (combined group). @entity1 were asked to use a scale of 0-10 in a Visual Analogue Scale (VAS) questionnaire about @entity158 during probe insertion (VAS 1) and prostate biopsy (VAS 2). RESULTS: The mean VAS 1 and VAS 2 scores were 0.7 and 4.9 for controls, 0.5 and 1.8 for @entity616 , 0.5 and 2.6 for the intrarectal cream group, and 0.4 and 1.8 for the combined group. The mean VAS 1 scores were not different between groups. However, the mean VAS 2 scores were significantly lower in @entity616 , @entity5403 - @entity3303 cream and combined groups compared to the control group (P < .001). In addition, the @entity616 group had significantly lower VAS 2 scores compared to the cream application group (P = .03). On the other hand, there was no difference between the @entity616 and combined groups (P = .8). CONCLUSION: Any form of anesthesia was superior to none. However, @entity616 alone seemed to be superior to @entity5403 - @entity3303 cream application in @entity1 undergoing prostate biopsy. Addition of @entity5403 - @entity3303 cream application to @entity616 may not provide better analgesia._

title: Novel Approach for @entity158 Control in XXXX Undergoing Prostate Biopsy: Iliohypogastric Nerve Block with or without Topical Application of @entity5403 - @entity3303 : A Randomized Controlled Trial.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: PURPOSE: The aim of this study was to investigate feasibility of exercise-based rehabilitation delivered after hospital discharge in @entity1 with intensive care unit-acquired weakness (ICU-AW). MATERIALS AND METHODS: Twenty adult @entity1 , mechanically ventilated for more than 48 hours, with ICU-AW diagnosis at ICU discharge were included in a pilot feasibility randomized controlled trial receiving a 16-session exercise-based rehabilitation program. Twenty-one @entity1 without ICU-AW participated in a nested observational cohort study. Feasibility, clinical, and @entity1 -centered outcomes were measured at hospital discharge and at 3 months. RESULTS: Intervention feasibility was demonstrated by high adherence and @entity1 acceptability, and absence of adverse events, but this must be offset by the low proportion of enrolment for those screened. The study was underpowered to detect effectiveness of the intervention. The use of manual muscle testing for the diagnosis of ICU-AW lacked robustness as an eligibility criterion and lacked discrimination for identifying rehabilitation requirements. Process evaluation of the trial identified methodological factors, categorized by "population," "intervention," "control group," and "outcome." CONCLUSIONS: Important data detailing the design, conduct, and implementation of a multicenter randomized controlled trial of exercise-based rehabilitation for survivors of @entity3124 after hospital discharge have been reported. REGISTRATION: Clinical Trials Identifier NCT00976807.

title: Exercise-based rehabilitation after hospital discharge for survivors of XXXX with intensive care unit-acquired weakness: A pilot feasibility trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3124 :: ('MESH:D016638', 'Disease') :: ['critical illness']

answer: @entity3124 :: (MESH:D016638,Disease) :: ['critical illness']


abstract: BACKGROUND AND PURPOSE: Reperfusion-associated @entity548 ( @entity548 ) is an important complication of recanalization therapy. A method to identify @entity64 victims that may undergo @entity548 will improve the @entity1 selection and safety of this treatment. In this study, we determined the relationship between timing of reperfusion and the frequency and severity of @entity548 , and whether very early dynamic contrast-enhanced (DCE) imaging predicts the occurrence of reperfusion-associated @entity548 in a model of experimental @entity64 . METHODS: Intraluminal suture occlusion of the middle cerebral artery was used to produce transient @entity63 in male @entity35 (n = 50). Reperfusion was performed by withdrawal of the occluding filament after 3 (n = 10), 4 (n = 10), 5 (n = 10), 6 (n = 10), or 7 (n = 10) hours. Magnetic resonance imaging studies were performed before reperfusion using DCE, susceptibility-weighted imaging, diffusion-weighted imaging, and T2- and T1-weighted imaging. Follow-up magnetic resonance imaging and histological studies were performed at 24 hours. RESULTS: Hemorrhagic transformation occurred by 24 hours after injury in 8 of 50 animals. The @entity548 rate increased with prolonged @entity63 duration. All animals exhibiting acute blood-brain barrier (BBB) perturbation subsequently developed @entity548 by 24 hours. Statistically significant differences in the BBB permeability parameters (P < 0.05) between the @entity548 group and non- @entity548 group were detected by DCE imaging. There were also statistically significant differences (P < 0.05) between the @entity548 area and adjacent @entity548 area. Among the permeability parameters, subcortex rK was the most sensitive and specific predictor of @entity548 . CONCLUSIONS: The results suggest that the use of quantitative BBB measurements may further improve early prediction and identification of @entity548 . The DCE parameters were the sensitive early independent predictor of reperfusion-associated @entity548 .

title: Prediction of Reperfusion-Associated Hemorrhagic Transformation Using Dynamic Contrast-Enhanced Imaging in a @entity35 XXXX Model.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['HT', 'hemorrhagic transformation']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia', 'ischemic']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague Dawley rats']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: BACKGROUND AND PURPOSE: Reperfusion-associated @entity548 ( @entity548 ) is an important complication of recanalization therapy. A method to identify @entity64 victims that may undergo @entity548 will improve the @entity1 selection and safety of this treatment. In this study, we determined the relationship between timing of reperfusion and the frequency and severity of @entity548 , and whether very early dynamic contrast-enhanced (DCE) imaging predicts the occurrence of reperfusion-associated @entity548 in a model of experimental @entity64 . METHODS: Intraluminal suture occlusion of the middle cerebral artery was used to produce transient @entity63 in male @entity35 (n = 50). Reperfusion was performed by withdrawal of the occluding filament after 3 (n = 10), 4 (n = 10), 5 (n = 10), 6 (n = 10), or 7 (n = 10) hours. Magnetic resonance imaging studies were performed before reperfusion using DCE, susceptibility-weighted imaging, diffusion-weighted imaging, and T2- and T1-weighted imaging. Follow-up magnetic resonance imaging and histological studies were performed at 24 hours. RESULTS: Hemorrhagic transformation occurred by 24 hours after injury in 8 of 50 animals. The @entity548 rate increased with prolonged @entity63 duration. All animals exhibiting acute blood-brain barrier (BBB) perturbation subsequently developed @entity548 by 24 hours. Statistically significant differences in the BBB permeability parameters (P < 0.05) between the @entity548 group and non- @entity548 group were detected by DCE imaging. There were also statistically significant differences (P < 0.05) between the @entity548 area and adjacent @entity548 area. Among the permeability parameters, subcortex rK was the most sensitive and specific predictor of @entity548 . CONCLUSIONS: The results suggest that the use of quantitative BBB measurements may further improve early prediction and identification of @entity548 . The DCE parameters were the sensitive early independent predictor of reperfusion-associated @entity548 .

title: Prediction of Reperfusion-Associated Hemorrhagic Transformation Using Dynamic Contrast-Enhanced Imaging in a XXXX @entity64 Model.

answer: @entity35 :: (10116,Species) :: ['Rat']


abstract: OBJECTIVE: This report describes three @entity1 with @entity2598 who were treated in the United States and developed for severe @entity3124 and @entity881 . The @entity1 received mechanical ventilation, renal replacement therapy, invasive monitoring, vasopressor support, and investigational therapies for @entity2598 . DATA SOURCES: @entity1 medical records from three tertiary care centers (Emory University Hospital, University of Nebraska Medical Center, and Texas Health Presbyterian Dallas Hospital). STUDY SELECTION: Not applicable. DATA EXTRACTION: Not applicable. DATA SYNTHESIS: Not applicable. CONCLUSION: In the severe form, @entity1 with @entity2598 may require life-sustaining therapy, including mechanical ventilation and renal replacement therapy. In conjunction with other reported cases, this series suggests that respiratory and @entity177 may occur in severe @entity2598 , especially in @entity1 burdened with high viral loads. @entity2598 complicated by @entity881 can be survivable with the application of advanced life support measures. This collective, multicenter experience is presented with the hope that it may inform future treatment of @entity1 with @entity2598 requiring critical care treatment.

title: Critical Care for Multiple Organ Failure Secondary to XXXX in the United States.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity2598 :: ('MESH:D019142', 'Disease') :: ['Ebola virus disease']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure secondary to Ebola virus infection', 'multiple organ failure']

answer: @entity2598 :: (MESH:D019142,Disease) :: ['Ebola Virus Disease']


abstract: BACKGROUND AND AIMS: @entity730 ( @entity730 ) or @entity13375 is most commonly seen in @entity454 and is associated with significant morbidity and mortality. Several small case series have suggested a role for hyperbaric oxygen therapy (HBOT) in the treatment of this condition. The aim of this study was to determine whether HBOT is effective in @entity13375 lesions and to determine if there are any @entity1 factors which can predict wound healing and @entity1 survival. METHODS: We identified by retrospective review all cases of @entity730 referred to our institution for treatment with HBOT. We documented the clinical and biochemical parameters of this @entity1 population, the size and distribution of the lesions as well as wound outcomes and @entity1 survival following treatment. RESULTS: A total 46 @entity1 were identified with @entity730 associated with @entity177 . Of the 46 @entity1 , only 34 received a full course of HBOT. The balance were deemed unsuitable for treatment or were unable to tolerate treatment and were palliated. Of the 34 @entity1 that received a full course of HBOT, 58% showed improvement in their wound scores, with more than half of these @entity1 having complete healing of their wounds. The balance did not benefit from the therapy and had a very poor prognosis with most dying within 12 months of referral. Those that benefited from HBOT survived on average for more than 3 years. The only factor significantly associated with improved wound healing and survival was @entity6 . CONCLUSION: In an area where clinical trials are very difficult to perform, this retrospective analysis suggests a role for HBOT in the treatment of @entity730 with more than half of the treated @entity1 benefiting and surviving for on average more than 3 years.

title: Hyperbaric Oxygen in the Treatment of XXXX : A case series and literature review.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['CUA', 'Calcific uraemic arteriolopathy']

entities_list: @entity13375 :: ('MESH:D002115', 'Disease') :: ['calciphylaxis', 'healing calciphylaxis']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end stage renal disease']

answer: @entity13375 :: (MESH:D002115,Disease) :: ['Calciphylaxis']


abstract: OBJECTIVES: To analyse the @entity1355 exposure characteristics and @entity2615 trend in textile workers operating in the larger Tuscan textile industrial province of Prato between 1988 and 2012. METHODS: All cases of textile workers recorded by the Tuscan @entity2615 register are considered. The demographic and clinical characteristics and @entity1355 exposure of cases working in the province of Prato are examined. Crude incidence rates between 1988 and 2012 and their 95% confidence intervals (CI) are calculated in rag sorters and other textile workers. The trends of standardized rates are also evaluated, as well as the sources of occupational @entity1355 exposure from occupational histories of cases affected by other @entity66 in rag sorters. RESULTS: One hundred and seventy-two @entity3620 ( @entity3620 ) have been diagnosed in textile workers in Tuscany. Among these, 46.5% were residents in the province of Prato at the time of diagnosis, half of whom working as rag sorters. All rag sorters with MM are classified as occupationally @entity1355 exposed, while 71.7% are other textile workers exposed to @entity1355 . The estimated crude incidence rate in rag sorters in Prato ranges from 74.1*100000 (95% CI: 52.5-101.8) to 166.8*100000 (95% CI: 118.1-229.0). The standardized rates in Prato rag sorters appeared higher throughout the 1990s while in other Prato textile workers the rates increased later on, at the very end of the 1990s. Another 40 cases of @entity66 in rag sorters were also collected. CONCLUSIONS: A very high incidence of @entity3620 was observed in textile workers in Prato, especially among rag sorters. This result, together with the high number of other @entity66 in rag sorters, strongly supports the hypothesis of diffuse @entity1355 exposure in rag sorting, in the absence of any other relevant aetiological factor for @entity3620 .

title: XXXX in Textile Rag Sorters.

entities_list: @entity3620 :: ('MESH:C562839', 'Disease') :: ['malignant mesothelioma', 'MMs', 'malignant mesotheliomas']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['asbestos-related diseases']

entities_list: @entity2615 :: ('MESH:D008654', 'Disease') :: ['mesothelioma']

answer: @entity3620 :: (MESH:C562839,Disease) :: ['Malignant Mesotheliomas']