abstract: Eleven physically active @entity1 with systemic @entity101 were studied after 5 weeks of treatment with placebo, @entity2165 or @entity1169 . A double-blind, crossover randomized design was used. Blood pressure (BP), heart rate (HR), physical performance capacity, rate of perceived exertion and blood @entity880 concentrations were measured during rest, exercise to exhaustion and postexercise, at 8 and 24 hours after intake of the last dose. Blood pressure at rest and during exercise was similarly decreased with both drugs (8 and 24 hours), and there was no difference between 8 and 24 hours with any of the treatments. Heart rate (8 hours) was decreased similarly by both drugs, but after 24 hours, HR at increased workloads (above 120 watts) was higher with @entity2165 compared with @entity1169 . Maximal HR was lower with @entity1169 than @entity2165 at both 8 and 24 hours. Maximal exercise loads (8 and 24 hours) were 231 and 232 watts with placebo, 211 and 212 with @entity1169 and 228 and 227 with @entity2165 . That is, maximal workload was decreased with @entity1169 compared with placebo and @entity2165 at both 8 and 24 hours. No difference was found between placebo and @entity2165 at either 8 or 24 hours. The rate of perceived exertion values were higher with @entity1169 than @entity2165 . Blood @entity880 concentrations did not differ according to treatments. The results indicate that @entity2165 , when given in a dose that decreases resting and exercise BP to the same extent as @entity1169 , limits physical performance less than @entity1169 .

title: Effect of beta 1-selective and nonselective beta blockade on blood pressure relative to physical performance in @entity1 with systemic XXXX .

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity2165 :: ('MESH:D001262', 'Chemical') :: ['atenolol']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: Eleven physically active @entity1 with systemic @entity101 were studied after 5 weeks of treatment with placebo, @entity2165 or @entity1169 . A double-blind, crossover randomized design was used. Blood pressure (BP), heart rate (HR), physical performance capacity, rate of perceived exertion and blood @entity880 concentrations were measured during rest, exercise to exhaustion and postexercise, at 8 and 24 hours after intake of the last dose. Blood pressure at rest and during exercise was similarly decreased with both drugs (8 and 24 hours), and there was no difference between 8 and 24 hours with any of the treatments. Heart rate (8 hours) was decreased similarly by both drugs, but after 24 hours, HR at increased workloads (above 120 watts) was higher with @entity2165 compared with @entity1169 . Maximal HR was lower with @entity1169 than @entity2165 at both 8 and 24 hours. Maximal exercise loads (8 and 24 hours) were 231 and 232 watts with placebo, 211 and 212 with @entity1169 and 228 and 227 with @entity2165 . That is, maximal workload was decreased with @entity1169 compared with placebo and @entity2165 at both 8 and 24 hours. No difference was found between placebo and @entity2165 at either 8 or 24 hours. The rate of perceived exertion values were higher with @entity1169 than @entity2165 . Blood @entity880 concentrations did not differ according to treatments. The results indicate that @entity2165 , when given in a dose that decreases resting and exercise BP to the same extent as @entity1169 , limits physical performance less than @entity1169 .

title: Effect of beta 1-selective and nonselective beta blockade on blood pressure relative to physical performance in XXXX with systemic @entity101 .

answer: @entity1 :: (9606,Species) :: ['men']


abstract: @entity299 occurs frequently in @entity1 with @entity2916 ( @entity2916 ). Although there have been case reports of detection of @entity299 by 2-dimensional echocardiography, no study has examined the frequency of @entity299 detected by cardiac ultrasound in @entity1 with @entity2916 . Echocardiography was performed in 16 consecutive @entity1 with @entity2916 . Physical examination revealed normal cardiac findings in each. Discrete areas of increased acoustic density were found in 8 of the 16 @entity1 (50%). The maximum diameters ranged from 3 to 20 mm. Multiple areas were found in 3 of 8. The left ventricle was involved in 5 of the 8. Six masses were intracavitary and 8 were intramyocardial. No atrial masses were seen. Left ventricular size and function were normal. Although other @entity5 cannot be excluded, the diagnosis of @entity299 is almost certain in these young @entity1 with @entity2916 . The male predominance and the high incidence of intracavitary and left ventricular masses are similar to those in reported autopsy series, also supporting the diagnosis of @entity299 . The prognosis and potential for growth of these masses are not known, but can be determined by longitudinal follow-up. Cardiac ultrasound should be considered for all @entity1 with @entity2916 regardless of physical findings.

title: Echocardiographic incidence of @entity299 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2916 :: ('MESH:D014402', 'Disease') :: ['tuberous sclerosis', 'TS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['Cardiac rhabdomyoma', 'cardiac rhabdomyoma']

answer: @entity2916 :: (MESH:D014402,Disease) :: ['tuberous sclerosis']


abstract: @entity299 occurs frequently in @entity1 with @entity2916 ( @entity2916 ). Although there have been case reports of detection of @entity299 by 2-dimensional echocardiography, no study has examined the frequency of @entity299 detected by cardiac ultrasound in @entity1 with @entity2916 . Echocardiography was performed in 16 consecutive @entity1 with @entity2916 . Physical examination revealed normal cardiac findings in each. Discrete areas of increased acoustic density were found in 8 of the 16 @entity1 (50%). The maximum diameters ranged from 3 to 20 mm. Multiple areas were found in 3 of 8. The left ventricle was involved in 5 of the 8. Six masses were intracavitary and 8 were intramyocardial. No atrial masses were seen. Left ventricular size and function were normal. Although other @entity5 cannot be excluded, the diagnosis of @entity299 is almost certain in these young @entity1 with @entity2916 . The male predominance and the high incidence of intracavitary and left ventricular masses are similar to those in reported autopsy series, also supporting the diagnosis of @entity299 . The prognosis and potential for growth of these masses are not known, but can be determined by longitudinal follow-up. Cardiac ultrasound should be considered for all @entity1 with @entity2916 regardless of physical findings.

title: Echocardiographic incidence of XXXX in @entity2916 .

answer: @entity299 :: (MESH:D006331,Disease) :: ['cardiac rhabdomyoma']


abstract: This study examined the effect of an orally active @entity2871 (TXA2) synthetase inhibitor (TSI) on the patency, TXA2 production, and platelet accumulation of reversed autogenous vein grafts. Ten @entity235 received TSI ( @entity19343 ) 10 mg/kg po q8 hr for 6 weeks, beginning 24 hr prior to surgery, while 15 control @entity235 were untreated. One jugular vein was harvested and stored in 37 degrees C saline for 1 hr to induce mild @entity130 (stored). Normal and stored jugular vein grafts (8 cm) were then implanted in opposite femoral arteries while 3-cm segments of the same veins were implanted in the carotid arteries. Femoral graft flow was restricted with a 5 Fr distal arterial stenosis and patency determined by arteriography at 1, 2, 4, and 6 weeks. Vein graft endothelial surface @entity3448 production was measured by RIA at graft implantation and in carotid grafts harvested at 1 week. 111In-labeled platelets were given iv 24 hr prior to carotid graft harvest to determine graft-platelet deposition. TSI treatment improved early (1 week) femoral vein graft patency from 63 to 89% (P less than 0.05), a trend that persisted for 6 weeks. Warm saline storage reduced 1-week graft patency from 83 to 63% (P less than 0.05), a difference that decreased with time. TSI treatment resulted in a marked decrease in TXB2 production, but was not associated with decreased 111In-labeled platelet deposition in carotid vein grafts. Warm saline storage increased graft-platelet deposition which was predominant at the arterial anastomoses. TSI treatment may improve early vein graft patency during the transient period of @entity130 .

title: Effect of XXXX synthetase inhibition on @entity235 autogenous vein grafts.

entities_list: @entity2871 :: ('CHEBI:26995', 'Chemical') :: ['thromboxane']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['endothelial injury']

answer: @entity2871 :: (CHEBI:26995,Chemical) :: ['thromboxane']


abstract: This study examined the effect of an orally active @entity2871 (TXA2) synthetase inhibitor (TSI) on the patency, TXA2 production, and platelet accumulation of reversed autogenous vein grafts. Ten @entity235 received TSI ( @entity19343 ) 10 mg/kg po q8 hr for 6 weeks, beginning 24 hr prior to surgery, while 15 control @entity235 were untreated. One jugular vein was harvested and stored in 37 degrees C saline for 1 hr to induce mild @entity130 (stored). Normal and stored jugular vein grafts (8 cm) were then implanted in opposite femoral arteries while 3-cm segments of the same veins were implanted in the carotid arteries. Femoral graft flow was restricted with a 5 Fr distal arterial stenosis and patency determined by arteriography at 1, 2, 4, and 6 weeks. Vein graft endothelial surface @entity3448 production was measured by RIA at graft implantation and in carotid grafts harvested at 1 week. 111In-labeled platelets were given iv 24 hr prior to carotid graft harvest to determine graft-platelet deposition. TSI treatment improved early (1 week) femoral vein graft patency from 63 to 89% (P less than 0.05), a trend that persisted for 6 weeks. Warm saline storage reduced 1-week graft patency from 83 to 63% (P less than 0.05), a difference that decreased with time. TSI treatment resulted in a marked decrease in TXB2 production, but was not associated with decreased 111In-labeled platelet deposition in carotid vein grafts. Warm saline storage increased graft-platelet deposition which was predominant at the arterial anastomoses. TSI treatment may improve early vein graft patency during the transient period of @entity130 .

title: Effect of @entity2871 synthetase inhibition on XXXX autogenous vein grafts.

answer: @entity235 :: (9615,Species) :: ['canine']


abstract: BACKGROUND: After chemotherapy for nonseminomatous @entity2969 (NSTGCT), residual masses or recurrent disease may contain a non-germ cell malignancy (NGCM). METHODS: Over 20 years, 369 @entity1 with disseminated NSTGCT were treated with @entity900 -based polychemotherapy at the University Medical Center Groningen. @entity41 masses were resected in 244 @entity1 and recurrent @entity5 masses in 37 @entity1 . Histology was reviewed, focusing on the presence of NGCM. RESULTS: Nine @entity1 developed an NGCM. Four @entity1 had an NGCM in the resected @entity41 mass after chemotherapy: three @entity1 had a @entity242 , and one @entity1 had both a @entity242 and an @entity420 . Five @entity1 developed a late recurrence with an NGCM after 39, 40, 72, 72, and 84 months. One @entity1 had a primitive @entity4969 , one had a @entity242 , and three had an @entity420 in the resected recurrent @entity5 mass. A complete surgical resection was achieved in five (56%) of the nine @entity1 . After a median follow-up of 48 months (range, 3-271 months), five @entity1 had no evidence of disease (56%), three @entity1 were @entity66 (33%), and one @entity1 was alive with disease (11%). CONCLUSIONS: @entity242 , @entity420 , or both in residual or recurrent @entity5 masses after combined-modality NSTGCT treatment are rare. Complete surgical resection of the @entity5 mass is the only curative treatment option.

title: Non-germ cell malignancy in residual or recurrent mass after chemotherapy for nonseminomatous XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['dead of disease']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumor', 'Residual tumor']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'Sarcoma']

entities_list: @entity4969 :: ('MESH:D017599', 'Disease') :: ['neuroectodermal tumor']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2969 :: ('MESH:C563236', 'Disease') :: ['testicular germ cell tumor']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity2969 :: (MESH:C563236,Disease) :: ['testicular germ cell tumor']


abstract: We investigated the possibility that altered cell calcium regulation may affect function of isolated Kyoto spontaneously @entity101 @entity35 (SHR) kidneys as compared with kidneys from @entity35 -Kyoto control (WKY) @entity35 . The kidneys were perfused at 120 and 160 mmHg. At 120 mmHg, SHR glomerular filtration rate (GFR) was 0.24 +/- 0.04 compared with WKY GFR of 0.70 +/- 0.10 ml/min (P = 0.001). At 160 mmHg, SHR GFR was 0.48 +/- 0.05 compared with WKY GFR of 1.09 +/- 0.05 ml/min (P less than 0.001). At 120 mmHg, addition of @entity1063 increased renal vascular resistance (RVR) by 50% and decreased SHR GFR by 27% and WKY GFR by 57% (P = 0.04). At 160 mmHg, @entity1063 elicited similar changes. Addition of @entity1855 , 5-10 microM, in the presence of @entity1063 returned RVR to 100-110% of control. With @entity1855 at 120 mmHg, SHR GFR increased to 0.84 +/- 0.23 ml/min, a value 3.5 times that of control (P = 0.03). In contrast, WKY GFR in the presence of @entity1063 and @entity1855 was 0.97 +/- 0.07 ml/min, unchanged from control (P = 0.07). At 160 mmHg, @entity1063 and @entity1855 also failed to increase WKY GFR above control (P = 0.4) but increased SHR GFR to 52% above control (P = 0.03). Isolated SHR kidneys exhibited exaggerated GFR responses to @entity1855 but not to @entity1063 . Abnormal cell calcium regulation may underlie the marked decrease in GFR when SHR kidneys are perfused acutely at normotensive perfusion pressures.

title: Glomerular response to XXXX by isolated spontaneously @entity101 @entity35 kidney.

entities_list: @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

answer: @entity1855 :: (MESH:D014700,Chemical) :: ['verapamil']


abstract: We investigated the possibility that altered cell calcium regulation may affect function of isolated Kyoto spontaneously @entity101 @entity35 (SHR) kidneys as compared with kidneys from @entity35 -Kyoto control (WKY) @entity35 . The kidneys were perfused at 120 and 160 mmHg. At 120 mmHg, SHR glomerular filtration rate (GFR) was 0.24 +/- 0.04 compared with WKY GFR of 0.70 +/- 0.10 ml/min (P = 0.001). At 160 mmHg, SHR GFR was 0.48 +/- 0.05 compared with WKY GFR of 1.09 +/- 0.05 ml/min (P less than 0.001). At 120 mmHg, addition of @entity1063 increased renal vascular resistance (RVR) by 50% and decreased SHR GFR by 27% and WKY GFR by 57% (P = 0.04). At 160 mmHg, @entity1063 elicited similar changes. Addition of @entity1855 , 5-10 microM, in the presence of @entity1063 returned RVR to 100-110% of control. With @entity1855 at 120 mmHg, SHR GFR increased to 0.84 +/- 0.23 ml/min, a value 3.5 times that of control (P = 0.03). In contrast, WKY GFR in the presence of @entity1063 and @entity1855 was 0.97 +/- 0.07 ml/min, unchanged from control (P = 0.07). At 160 mmHg, @entity1063 and @entity1855 also failed to increase WKY GFR above control (P = 0.4) but increased SHR GFR to 52% above control (P = 0.03). Isolated SHR kidneys exhibited exaggerated GFR responses to @entity1855 but not to @entity1063 . Abnormal cell calcium regulation may underlie the marked decrease in GFR when SHR kidneys are perfused acutely at normotensive perfusion pressures.

title: Glomerular response to @entity1855 by isolated spontaneously XXXX @entity35 kidney.

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: We investigated the possibility that altered cell calcium regulation may affect function of isolated Kyoto spontaneously @entity101 @entity35 (SHR) kidneys as compared with kidneys from @entity35 -Kyoto control (WKY) @entity35 . The kidneys were perfused at 120 and 160 mmHg. At 120 mmHg, SHR glomerular filtration rate (GFR) was 0.24 +/- 0.04 compared with WKY GFR of 0.70 +/- 0.10 ml/min (P = 0.001). At 160 mmHg, SHR GFR was 0.48 +/- 0.05 compared with WKY GFR of 1.09 +/- 0.05 ml/min (P less than 0.001). At 120 mmHg, addition of @entity1063 increased renal vascular resistance (RVR) by 50% and decreased SHR GFR by 27% and WKY GFR by 57% (P = 0.04). At 160 mmHg, @entity1063 elicited similar changes. Addition of @entity1855 , 5-10 microM, in the presence of @entity1063 returned RVR to 100-110% of control. With @entity1855 at 120 mmHg, SHR GFR increased to 0.84 +/- 0.23 ml/min, a value 3.5 times that of control (P = 0.03). In contrast, WKY GFR in the presence of @entity1063 and @entity1855 was 0.97 +/- 0.07 ml/min, unchanged from control (P = 0.07). At 160 mmHg, @entity1063 and @entity1855 also failed to increase WKY GFR above control (P = 0.4) but increased SHR GFR to 52% above control (P = 0.03). Isolated SHR kidneys exhibited exaggerated GFR responses to @entity1855 but not to @entity1063 . Abnormal cell calcium regulation may underlie the marked decrease in GFR when SHR kidneys are perfused acutely at normotensive perfusion pressures.

title: Glomerular response to @entity1855 by isolated spontaneously @entity101 XXXX kidney.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Because of the significant mortality associated with the conventional surgical approach to @entity1028 ( @entity1028 ) in the high risk @entity1 and in those with @entity1756 , we have developed a new approach to this problem, intraluminal @entity439 exclusion. This was achieved by an intraluminal prosthesis which approximated the diameter of the aorta above and below the @entity439 and is inserted through the femoral artery. The prosthesis consisted of biomedical grade elastomeric @entity2636 with a NITINOL and/or stainless steel frame and was designed in such a configuration that it could be compressed inside a 15 F catheter and then regain its original shape after being discharged inside the aorta. The @entity2636 prosthesis tolerated static pressures in excess of 300 Torr. Aneurysmal aortas were created in three adult @entity742 using large knitted Dacron pathches (6 X 9 cm) sewn onto a longitudinal aortotomy. After 4-6 weeks, an intraluminal prosthesis was passed transfemorally to the location of the @entity449 . Following satisfactory placement and expansion of the prosthesis, a laceration was produced in the aneurysmal wall. No bleeding developed, which confirmed the integrity of the prosthesis in excluding the @entity439 from the aorta proper. Pulsation in the iliac arteries indicated the presence of aortic blood flow through the prosthesis. Autopsy examination demonstrated directly that the prosthesis was open and that its two ends were fixed in the aorta above and below the @entity439 . The study has demonstrated that intraluminal @entity1028 exclusion could be achieved with an intraluminal @entity2636 prosthesis inserted through the femoral artery.

title: Transfemoral placement of intraluminal @entity2636 prosthesis for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysm']

entities_list: @entity2636 :: ('MESH:D011140', 'Chemical') :: ['polyurethane']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysms', 'AAA']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured aneurysms']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']


abstract: Because of the significant mortality associated with the conventional surgical approach to @entity1028 ( @entity1028 ) in the high risk @entity1 and in those with @entity1756 , we have developed a new approach to this problem, intraluminal @entity439 exclusion. This was achieved by an intraluminal prosthesis which approximated the diameter of the aorta above and below the @entity439 and is inserted through the femoral artery. The prosthesis consisted of biomedical grade elastomeric @entity2636 with a NITINOL and/or stainless steel frame and was designed in such a configuration that it could be compressed inside a 15 F catheter and then regain its original shape after being discharged inside the aorta. The @entity2636 prosthesis tolerated static pressures in excess of 300 Torr. Aneurysmal aortas were created in three adult @entity742 using large knitted Dacron pathches (6 X 9 cm) sewn onto a longitudinal aortotomy. After 4-6 weeks, an intraluminal prosthesis was passed transfemorally to the location of the @entity449 . Following satisfactory placement and expansion of the prosthesis, a laceration was produced in the aneurysmal wall. No bleeding developed, which confirmed the integrity of the prosthesis in excluding the @entity439 from the aorta proper. Pulsation in the iliac arteries indicated the presence of aortic blood flow through the prosthesis. Autopsy examination demonstrated directly that the prosthesis was open and that its two ends were fixed in the aorta above and below the @entity439 . The study has demonstrated that intraluminal @entity1028 exclusion could be achieved with an intraluminal @entity2636 prosthesis inserted through the femoral artery.

title: Transfemoral placement of intraluminal XXXX prosthesis for @entity1028 .

answer: @entity2636 :: (MESH:D011140,Chemical) :: ['polyurethane']


abstract: @entity3168 is a leading cause of @entity6766 in countries where consumption of meat and poultry is high. For example, each year in the United States, this organism is the second or third most common cause of confirmed cases of @entity6766 . Surveys of the incidence of this organism in retail foods were done in the 1960s without regard to whether isolates were enterotoxigenic. It is now known that not all strains of this organism possess the @entity28925 gene responsible for illness. We examined the incidence of this organism in 131 food samples from retail food stores in an area of the northeastern United States. Forty isolates were obtained by using the @entity68 milk method at 45 degrees C, with confirmation by use of motility @entity1507 and lactose gelatin media. The presence of the @entity3168 @entity28925 (cpe) and alpha toxin (cpa) genes was determined by PCR using previously published primer sequences. All isolates possessed cpa. None of the isolates were identified as carrying the cpe gene by this method or by another method using a @entity1859 -labeled gene probe. Consistent with these results, none of the sporulating-cell extracts contained @entity28925 as determined by reverse passive latex hemagglutination. Pulsed-field gel electrophoresis was used to determine the genetic relatedness of the isolates. About 5% of the isolates were considered to be closely related (2- to 3-band difference). The others were considered to be unrelated to one another. The results demonstrate the rarity of cpe(+) strains in retail foods and the genetic diversity among nonoutbreak strains.

title: Enterotoxigenicity and genetic relatedness of XXXX isolates from retail foods in the United States.

entities_list: @entity6766 :: ('MESH:D005517', 'Disease') :: ['bacterial food-borne illness', 'food-borne illness']

entities_list: @entity1859 :: ('MESH:D004076', 'Chemical') :: ['digoxigenin']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

entities_list: @entity3168 :: ('1502', 'Species') :: ['C. perfringens', 'Clostridium perfringens']

answer: @entity3168 :: (1502,Species) :: ['Clostridium perfringens']


abstract: After ejaculation, @entity1 spermatozoa must undergo capacitation to fertilize. Capacitation of @entity291 spermatozoa occurs in vitro in medium supplemented with heparin. Semen cryopreservation is an important tool for assisted reproduction, although the fertility of frozen-thawed spermatozoa is reduced, possibly due to precocious capacitation-like changes that are known to occur. Our purpose was to clarify the mechanisms involved in bull sperm cryocapacitation induced by cryopreservation. Our general hypothesis is that the signaling pathways that lead to capacitation are triggered by the cryopreservation procedure. Ejaculated @entity291 semen was divided into two aliquots and diluted in extender; one was then kept fresh, whereas the second was cryopreserved. Western blots of extracted sperm proteins with anti- @entity10393 antibody showed that capacitation, induced by either heparin in fresh sperm or cryopreservation (cryocapacitation), is associated with a differential profile of @entity10393 -containing proteins. Immunolocalization of @entity10393 -containing proteins in the fresh and cryopreserved spermatozoa showed that, after thawing, cryocapacitated sperm displayed labeling over the acrosomal region, whereas for fresh sperm, this labeling appeared after 5-h incubation with heparin. The @entity7914 assay and the ability of the sperm to undergo the @entity6579 -induced acrosome reaction were used to confirm that a subpopulation of cryopreserved sperm is capacitated at thawing, irrespective of heparin inclusion. Since @entity413 is known to inhibit heparin-induced capacitation, the semen extender was modified to include @entity413 as a means of inhibiting cryocapacitation; however, cryocapacitation was not prevented according to the @entity7914 assay and profile of @entity10393 -containing sperm proteins.

title: A differential mechanism is involved during heparin- and cryopreservation-induced capacitation of XXXX spermatozoa.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity6579 :: ('MESH:D008244', 'Chemical') :: ['lysophosphatidylcholine']

entities_list: @entity10393 :: ('CHEBI:74956', 'Chemical') :: ['phosphotyrosine']

entities_list: @entity7914 :: ('MESH:D002751', 'Chemical') :: ['chlortetracycline']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: The course of recovery of heart activity [assessed by heart rate, atrioventricular (AV) conduction time, monophasic action potentials, contractile force, and perfusion rate] from hypothermic @entity63 was studied on isolated perfused @entity35 hearts. The effect of control @entity63 was compared with various cardioplegic protective formulations based on high K+ content. During control hypothermic @entity63 (20 degrees C), the heart activity extinguished only gradually, action potentials were biphasic, AV conduction was extremely prolonged, and contractions were slow and relatively strong. On reperfusion (37 degrees C), the recovery of electrical activity was almost instantaneous and normalized within 2 min, whereas the contractile force remained substantially depressed. In contrast, K+-containing cardioplegic solutions stopped the heart within several cycles. Postarrest recovery was delayed and transitorily associated with severe @entity943 ( @entity713 , repetitive afterdepolarizations and oscillations during elevated plateau, and @entity2224 ). Nevertheless, the action potentials as well as the contractile force virtually normalized in 10-15 min. @entity8162 -containing cardioplegic solutions were ineffective in preventing the onset of postarrest reperfusion @entity943 , whereas addition of @entity594 to the K+-containing cardioplegic solutions largely prevented these @entity943 , and contractile force was further improved by high concentrations of @entity413 . The data indicate that postarrest electrical and mechanical recovery do not recover in parallel. Furthermore, high concentrations of @entity460 antagonist and @entity413 preserve the electrical and mechanical properties of the cardiac muscle during periods of @entity1167 .

title: Differences in electrical and mechanical recovery from XXXX @entity1167 and cardioplegia.

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic arrest', 'ischemia']

entities_list: @entity8162 :: ('MESH:D011343', 'Chemical') :: ['Procaine']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity594 :: ('MESH:D009543', 'Chemical') :: ['nifedipine']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias']

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemic']


abstract: The course of recovery of heart activity [assessed by heart rate, atrioventricular (AV) conduction time, monophasic action potentials, contractile force, and perfusion rate] from hypothermic @entity63 was studied on isolated perfused @entity35 hearts. The effect of control @entity63 was compared with various cardioplegic protective formulations based on high K+ content. During control hypothermic @entity63 (20 degrees C), the heart activity extinguished only gradually, action potentials were biphasic, AV conduction was extremely prolonged, and contractions were slow and relatively strong. On reperfusion (37 degrees C), the recovery of electrical activity was almost instantaneous and normalized within 2 min, whereas the contractile force remained substantially depressed. In contrast, K+-containing cardioplegic solutions stopped the heart within several cycles. Postarrest recovery was delayed and transitorily associated with severe @entity943 ( @entity713 , repetitive afterdepolarizations and oscillations during elevated plateau, and @entity2224 ). Nevertheless, the action potentials as well as the contractile force virtually normalized in 10-15 min. @entity8162 -containing cardioplegic solutions were ineffective in preventing the onset of postarrest reperfusion @entity943 , whereas addition of @entity594 to the K+-containing cardioplegic solutions largely prevented these @entity943 , and contractile force was further improved by high concentrations of @entity413 . The data indicate that postarrest electrical and mechanical recovery do not recover in parallel. Furthermore, high concentrations of @entity460 antagonist and @entity413 preserve the electrical and mechanical properties of the cardiac muscle during periods of @entity1167 .

title: Differences in electrical and mechanical recovery from @entity63 XXXX and cardioplegia.

answer: @entity1167 :: (MESH:D006323,Disease) :: ['heart arrest']


abstract: @entity114 has been the antimicrobial of choice for the treatment of @entity4195 infections for almost six decades. Although @entity114 -resistant isolates have not been described to date, clinical failures have been reported after treatment with @entity7660 . In this study, we analysed the antimicrobial susceptibility and genetic diversity of @entity4195 isolates obtained from healthy carriers or @entity1 in different cities in the south and south east of Brazil. The MICs were determined for @entity114 and seven other antimicrobials. @entity114 tolerance was also investigated. Genetic diversity was analysed by PFGE after SmaI fragmentation of the genomic DNA. All 211 isolates tested were susceptible to @entity114 (MIC 0.0025-0.02 mg l(-1)). Four isolates were moderately @entity114 -tolerant (MBC/MIC = 16 mg l(-1)). Most of the other drugs tested were very active against the strains examined, except for @entity803 , to which 50 % of strains were resistant. We also found extensive genetic diversity, in that 60 different patterns were recognized in the 96 strains studied. Indeed, we found no correlation between @entity803 resistance and clonality. Despite this diversity, some PFGE patterns persisted for up to 18 years and specific clone types were spread over different geographical locations

title: Antimicrobial susceptibility patterns and genomic diversity in strains of XXXX isolated in 1978-1997 in different Brazilian cities.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity114 :: ('MESH:D010406', 'Chemical') :: ['Penicillin', 'penicillin']

entities_list: @entity7660 :: ('MESH:D047090', 'Chemical') :: ['beta-lactams']

entities_list: @entity4195 :: ('1314', 'Species') :: ['Streptococcus pyogenes', 'S. pyogenes']

entities_list: @entity803 :: ('MESH:D013752', 'Chemical') :: ['tetracycline']

answer: @entity4195 :: (1314,Species) :: ['Streptococcus pyogenes']


abstract: A sex difference in the LH rise after gonadectomy is clearly observable in the @entity35 . While male @entity35 respond with an early (10-12 h) increase in LH after orchidectomy, a delayed response (2-3 days) is recorded after ovariectomy. In this study we tested the hypothesis that the delayed response to gonadectomy in the E2-treated males is due to a more prolonged retention of E2 (when compared with the corresponding male feedback signal, @entity251 ) within specific central nuclear receptor sites. Orchidectomized (ORDX) animals implanted with either empty or E2-filled Silastic capsules were sacrificed at 0, 24, 48 and 72 h after ORDX or E2-capsule removal. LH levels in ORDX @entity35 rose several-fold by 24 h, whereas E2-treated, ORDX @entity35 , showed no changes in peripheral LH levels until 72 h after E2-capsule removal. At the time of E2-capsule removal (0 h) large increases in nuclear @entity53 receptor (NER) levels were seen in anterior pituitary, preoptic area, and @entity2339 ( @entity2339 ). Twenty-four hours after E2-capsule removal, NER levels were still high in the 3 areas, and by 48 h NER values had returned to control (ORDX) levels, with the exception of @entity2339 where they were slightly but significantly elevated. The increase in NER, as well as the subsequent decline after E2-capsule removal was paralleled by similar changes in cytosolic @entity1871 receptor (CPR) levels in all three regions. Cytosolic @entity251 levels were not changed by the E2-treatment. The results indicate that the feminized response to orchidectomy observed in E2-implanted males is related to a prolonged retention of the E2-receptor in nuclear sites. Further, they indicate that E2-treatment in males, as is the case in females, can induce a marked increase in progestin receptor levels within specific brain regions as well as in the pituitary. The reduction in NER and CPR levels to castrate values precedes the first detectable increase in peripheral LH levels. In conclusion, the pattern of LH rise after gonadectomy in the @entity35 is dependent upon the steroidal milieu at the time of removal of the gonads.

title: Estrogenic feminization of the LH response to orchidectomy: association with prolonged nuclear XXXX receptor retention and induction of cytoplasmic progestin receptors in brain and pituitary.

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin']

entities_list: @entity2339 :: ('MESH:D007029', 'Disease') :: ['HYP', 'hypothalamus']

answer: @entity53 :: (MESH:D004958,Chemical) :: ['estradiol']


abstract: As the inclusion criteria for breast conservation therapy have continued to evolve to include @entity5 , very large breasts, and central @entity5 , the potential for significant disfigurement after breast conservation therapy has also increased. This has led some centers to develop coordinated oncology-plastic surgery approaches to ensure both adequate @entity5 resection and aesthetic appearance to the breasts. The authors applied this principle to a specific group of @entity0 @entity1 -- @entity1 with @entity21879 --who would benefit from reduction mammaplasty. Eleven @entity1 were identified from the senior author's (S.L.S.) reconstructive practice who underwent breast conservation therapy followed by breast reconfiguration and bilateral reduction mammaplasty. Preoperative brassiere sizes ranged from 34D to 46D. All @entity1 had immediate reduction after frozen sections from the lumpectomy/partial mastectomy margins were determined to be negative. A total of 22 reduction mammaplasties were performed (eight free-nipple grafts, five inferior pedicle flaps, seven superomedial pedicle flaps, and two superolateral flaps) and an average of 1085 g was removed per breast. All @entity1 underwent radiation therapy postoperatively. There were eight minor complications in six @entity1 (one @entity1410 , one keloid, one radiation burn, two cases of @entity4182 , and three cases of fat @entity39 ). After an average of 24 months' follow-up, there were no local recurrences and one @entity204 from distant @entity3 . Seven of the 11 @entity1 were available and agreed to rate their aesthetic satisfaction on the basis of a scale from 1 to 4, with 4 being the best. The mean satisfaction score was 3.3. Aesthetic outcomes before radiation therapy and after radiation therapy were evaluated by a panel of plastic surgery residents blinded to the purpose of the study. Using a scale of 1 to 4, the aesthetic mean before radiation therapy was 2.9 and the aesthetic mean after radiation therapy was 3.03. By combining breast conservation therapy with breast reconfiguration or reduction in large-breasted @entity1 , multiple benefits are derived. Larger segmental or partial mastectomies can be performed without disfigurement risk, ensuring adequate surgical margins. Immediate reconfiguration of the breast with reduction of the contralateral side creates symmetric, aesthetically pleasing breasts; allows contralateral breast tissue to be evaluated; and spares @entity1 from undergoing a second operative procedure. Such a coordinated program gives @entity1 an important boost, both physically and psychologically, during management of their @entity0 .

title: Experience with reduction mammaplasty combined with breast conservation therapy in the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity4182 :: ('MESH:D017496', 'Disease') :: ['nipple hypopigmentation']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'lower quadrant tumors', 'tumors']

entities_list: @entity21879 :: ('MESH:C536821', 'Disease') :: ['macromastia']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity1286 , @entity1340 , and @entity6058 on stress and immune responses in @entity1 who underwent modified radical mastectomy. @entity1 : Sixty @entity1 randomly assigned to receive IV @entity1286 5 mg (group M, n=20), @entity1340 100 mg (group T, n=20), or @entity6058 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity701 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity2940 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity701 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity404 , @entity405 , and @entity2940 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity404 , @entity405 , and @entity2940 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity405 , and @entity2940 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity404 , and @entity405 decreased in group M compared with group T (P <=0.048) and @entity404 and @entity2940 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity1286 , @entity1340 , and @entity6058 suppressed stress and immune responses. @entity6058 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous @entity1286 , XXXX , and @entity6058 on Stress and Immune Responses in @entity1 Undergoing Modified Radical Mastectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity1340 :: ('MESH:D014147', 'Chemical') :: ['tramadol']

entities_list: @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac', 'Ketorolac']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

answer: @entity1340 :: (MESH:D014147,Chemical) :: ['Tramadol']


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity1286 , @entity1340 , and @entity6058 on stress and immune responses in @entity1 who underwent modified radical mastectomy. @entity1 : Sixty @entity1 randomly assigned to receive IV @entity1286 5 mg (group M, n=20), @entity1340 100 mg (group T, n=20), or @entity6058 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity701 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity2940 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity701 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity404 , @entity405 , and @entity2940 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity404 , @entity405 , and @entity2940 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity405 , and @entity2940 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity404 , and @entity405 decreased in group M compared with group T (P <=0.048) and @entity404 and @entity2940 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity1286 , @entity1340 , and @entity6058 suppressed stress and immune responses. @entity6058 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous @entity1286 , @entity1340 , and XXXX on Stress and Immune Responses in @entity1 Undergoing Modified Radical Mastectomy.

answer: @entity6058 :: (MESH:D020910,Chemical) :: ['Ketorolac']


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity1286 , @entity1340 , and @entity6058 on stress and immune responses in @entity1 who underwent modified radical mastectomy. @entity1 : Sixty @entity1 randomly assigned to receive IV @entity1286 5 mg (group M, n=20), @entity1340 100 mg (group T, n=20), or @entity6058 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity701 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity2940 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity701 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity404 , @entity405 , and @entity2940 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity404 , @entity405 , and @entity2940 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity405 , and @entity2940 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity404 , and @entity405 decreased in group M compared with group T (P <=0.048) and @entity404 and @entity2940 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity1286 , @entity1340 , and @entity6058 suppressed stress and immune responses. @entity6058 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous XXXX , @entity1340 , and @entity6058 on Stress and Immune Responses in @entity1 Undergoing Modified Radical Mastectomy.

answer: @entity1286 :: (MESH:D009020,Chemical) :: ['Morphine']


abstract: OBJECTIVES: Analgesics had been suspected of impairing various immune functions either directly or indirectly. Our primary objective was to compare the effects of intravenous (IV) @entity1286 , @entity1340 , and @entity6058 on stress and immune responses in @entity1 who underwent modified radical mastectomy. @entity1 : Sixty @entity1 randomly assigned to receive IV @entity1286 5 mg (group M, n=20), @entity1340 100 mg (group T, n=20), or @entity6058 60 mg (group K, n=20) at the end of surgery. METHODS: Serum @entity701 , prolactin were measured immediately, 40 minutes, and 24 hours postoperatively. Expressions of peripheral T lymphocytes (CD3, CD3CD4, CD3CD8) and natural killer cells (CD3, @entity2940 ) were measured as percentages of total lymphocytes by flow cytometry immediately, 90 minutes, and 24 hours postoperatively. RESULTS: After 40 minutes, @entity701 level increased but prolactin decreased significantly (P=0.001), then both decreased after 24 hours (P=0.001) compared with baseline within the 3 groups. CD3, @entity404 , @entity405 , and @entity2940 significantly decreased at 90 minutes and 24 hours (P <=0.033) compared with baseline in the 3 groups. @entity404 , @entity405 , and @entity2940 significantly decreased in group M, compared with group T and K (P <=0.016) and CD3, @entity405 , and @entity2940 in group T compared with group K at 90 minutes (P <=0.024) postoperatively. After 24 hours, @entity404 , and @entity405 decreased in group M compared with group T (P <=0.048) and @entity404 and @entity2940 in groups M and T compared with group K (P <=0.049). CONCLUSIONS: IV @entity1286 , @entity1340 , and @entity6058 suppressed stress and immune responses. @entity6058 was the least immunosuppressive among the 3 drugs.

title: Comparison Between the Effects of Intravenous @entity1286 , @entity1340 , and @entity6058 on Stress and Immune Responses in XXXX Undergoing Modified Radical Mastectomy.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVE: To investigate whether @entity5570 in M  ni  re's Disease could be diagnosed by comparing vestibular evoked myogenic potential (VEMP) before and after @entity1483 administration (F-VEMP). STUDY DESIGN: Retrospective study. SETTING: University hospital. INTERVENTION: @entity1483 administration. @entity1 : Twenty-five affected ears of @entity1 with unilateral M  ni  re's Disease were studied. The @entity1 had received confirmed diagnoses M  ni  re's Disease; thus, the presence of @entity5570 was suggested. For the control, 22 ears of 11 normal healthy volunteers who had never had vertigo or hearing disturbance were used. MAIN OUTCOME MEASURE: The amplitude of the @entity4668 -n23 biphasic wave before and after @entity1483 administration. RESULTS: The amplitude of the @entity4668 -n23 biphasic wave was significantly enlarged in 7 of 18 cases in which it could be detected before diuretic loading. The biphasic waves appeared after diuretic loading in 3 of 7 cases in which it could not be recorded before loading. Thus, the positive ratio of F-VEMP for unilateral M  ni  re's Disease was considered to be 40% (10 of 25). The ratio was similar to that of the conventional examinations for @entity5570 such as the @entity653 test, @entity1483 test, and electrocochleogram. CONCLUSION: The F-VEMP test may be useful in the diagnosis of @entity5570 .

title: XXXX loading vestibular evoked myogenic potential for unilateral M  ni  re's disease.

entities_list: @entity5570 :: ('MESH:D018159', 'Disease') :: ['endolymphatic hydrops']

entities_list: @entity1483 :: ('MESH:D005665', 'Chemical') :: ['furosemide', 'Furosemide']

entities_list: @entity653 :: ('MESH:D005990', 'Chemical') :: ['glycerol']

answer: @entity1483 :: (MESH:D005665,Chemical) :: ['Furosemide']


abstract: @entity2124 is a pituitary polypeptide hormone regulating growth in paediatric age as well as inducing anabolic actions directly or @entity442 mediated in adult age. Particularly, in many animals GH and @entity442 receptors were observed in cardiac myocyte membrane. GH modifies left ventricle structure and function. As concerns spontaneous GH secretion, some data suggest that pituitary gland can have a compensatory role on endocrine response to @entity712 . @entity712 stage was directly correlated to nocturnal GH levels. All GH spontaneous night secretion parameters as well as @entity442 levels showed a range between normal @entity1 and very high spontaneous secretion. Therefore in these @entity1 there are either a GH peripheric resistance or a reduction of the activity of GH/ @entity442 axis. Anyhow in our @entity1 , GH 24 hour infusion was inducing a 5 fold increase in GH concentration and a 50% increase in basal @entity442 levels. Anker et al. suggested to evaluate nutritional state in @entity712 @entity1 , observing no differences in non-cachectic @entity1 vs controls, while cachectic @entity1 presented a typical @entity18197 . Interestingly, cardiovascular effects of GH administration seem to be only marginally correlated to hemodynamic basal state. On the other hand basal hormonal setting of the @entity1 seems to correlate to the GH-induced cardiovascular response. In fact, low basal @entity442 but high basal GH @entity1 presented the worst endocrine and cardiovascular response to GH infusion. In literature there are controversial data about GH treatment in @entity1 with @entity712 . The heterogeneity of the population could be the reason for this discrepancy. Besides very different @entity442 responses to GH have been reported. Therefore, as there is good clinical evidence that GH acute infusion can improve @entity712 , it seems to be necessary firstly to evaluate the basal endocrine status of the @entity1 . Particularly attention should be given to those @entity1 that present a peripheric GH resistance. On the other hand, those @entity1 with a reduced pituitary GH reserve are supposed to have very beneficial effects from GH treatment.

title: [ @entity2124 secretion in XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure', 'chronic heart failure', 'heart failure']

entities_list: @entity18197 :: ('MESH:D046150', 'Disease') :: ['GH resistance syndrome']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: @entity2124 is a pituitary polypeptide hormone regulating growth in paediatric age as well as inducing anabolic actions directly or @entity442 mediated in adult age. Particularly, in many animals GH and @entity442 receptors were observed in cardiac myocyte membrane. GH modifies left ventricle structure and function. As concerns spontaneous GH secretion, some data suggest that pituitary gland can have a compensatory role on endocrine response to @entity712 . @entity712 stage was directly correlated to nocturnal GH levels. All GH spontaneous night secretion parameters as well as @entity442 levels showed a range between normal @entity1 and very high spontaneous secretion. Therefore in these @entity1 there are either a GH peripheric resistance or a reduction of the activity of GH/ @entity442 axis. Anyhow in our @entity1 , GH 24 hour infusion was inducing a 5 fold increase in GH concentration and a 50% increase in basal @entity442 levels. Anker et al. suggested to evaluate nutritional state in @entity712 @entity1 , observing no differences in non-cachectic @entity1 vs controls, while cachectic @entity1 presented a typical @entity18197 . Interestingly, cardiovascular effects of GH administration seem to be only marginally correlated to hemodynamic basal state. On the other hand basal hormonal setting of the @entity1 seems to correlate to the GH-induced cardiovascular response. In fact, low basal @entity442 but high basal GH @entity1 presented the worst endocrine and cardiovascular response to GH infusion. In literature there are controversial data about GH treatment in @entity1 with @entity712 . The heterogeneity of the population could be the reason for this discrepancy. Besides very different @entity442 responses to GH have been reported. Therefore, as there is good clinical evidence that GH acute infusion can improve @entity712 , it seems to be necessary firstly to evaluate the basal endocrine status of the @entity1 . Particularly attention should be given to those @entity1 that present a peripheric GH resistance. On the other hand, those @entity1 with a reduced pituitary GH reserve are supposed to have very beneficial effects from GH treatment.

title: [ XXXX secretion in @entity712 ].

answer: @entity2124 :: (2688,Gene) :: ['Growth hormone']


abstract: A discussion of the thermodynamic aspects of a relatively new treatment method for @entity2967 of the bone is presented in this paper. The advantages of implanting @entity3677 acrylic bone cement into a curetted @entity5 site are briefly discussed and placed in perspective relative to more prevalent surgical treatments. As the bone cement self-heats while curing, the possibility of @entity39 in the bone exists. However, the damage due to heat may be beneficial in reducing the rate of @entity5 recurrence. A thermodynamic consideration of the treatment situation appears to be warranted. After a general introduction and a brief literature review, the theoretical thermodynamic equations are developed. Once the basic equations for the heat transfer from the cement or the bone are derived, there is then a discussion of the various characteristics of bone and @entity3677 crucial to the analysis, such as, thermal conductivity, specific heat, density, and heat generation parameters. Finally, in order to reduce the theory to a form which may be used practically, the equations derived are written in terms of finite-difference equations, which approximate them numerically. Different equations are written for each type of @entity5044 encountered in the cement-bone system as spacial variances in material and geometry occur. The equations derived may be used to model the system allowing one to predict the time-dependent temperature distribution in bone during the curing of acrylic cement. Using computer techniques to reduce the equations obtained from this analysis, and knowing the temperature at which adjacent cells die, a zone of @entity39 may be mapped surrounding the acrylic impact.

title: Thermodynamic considerations of acrylic cement implant at the site of XXXX of the bone.

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'heat necrosis']

entities_list: @entity5044 :: ('OMIM:143470', 'Disease') :: ['heat transfer condition']

entities_list: @entity2967 :: ('MESH:D005870', 'Disease') :: ['giant cell tumors']

entities_list: @entity3677 :: ('MESH:D020366', 'Chemical') :: ['methylmethacrylate']

answer: @entity2967 :: (MESH:D005870,Disease) :: ['giant cell tumors']


abstract: @entity3 ( @entity3 ) is relatively common in allogeneic @entity8 ( @entity8 ) recipients. Although lungs are the most common site, central nervous system (CNS) involvement is also observed in this setting. We have retrospectively studied 14 cases of CNS @entity2381 found in a cohort of 455 allogeneic @entity8 recipients (incidence 3%). All @entity1 , except one, had experienced @entity2132 treated with high-dose @entity1667 , and eight @entity1 (57%) had also received ATG. The median time to the diagnosis of CNS @entity2381 was 124 days (range 49-347 days) from @entity8 . @entity57 had been diagnosed earlier in four @entity1 (29%). The most common initial symptoms of CNS @entity2381 were @entity410 , @entity1269 , and mental alteration. Neuroradiological studies revealed single (two @entity1 ) or multiple (seven @entity1 ) focal lesions of 0.2-9 cm in diameter. Despite clinical suspicion in many @entity1 , a confirmed diagnosis of CNS @entity2381 was made during life in only one @entity1 . A total of 12 @entity1 (86%) received @entity2379 . Despite therapy, all @entity1 died 0-27 days (median seven days) after the initial CNS symptoms. CNS @entity2381 is not uncommon in allogeneic @entity8 recipients. Clinical manifestations are usually dramatic and progress quickly. Earlier and more effective treatment of @entity3 is needed to prevent dissemination of infection into the CNS.

title: Central nervous system aspergillosis in allogeneic XXXX recipients.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplant']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsions']

entities_list: @entity57 :: ('MESH:D055732', 'Disease') :: ['Pulmonary aspergillosis']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis']

entities_list: @entity2381 :: ('MESH:D001228', 'Disease') :: ['aspergillosis']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['acute graft-versus-host disease']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['Invasive aspergillosis', 'IA']

answer: @entity8 :: (MESH:D007674,Disease) :: ['stem cell transplant']


abstract: The role of selective intestinal decontamination with @entity2887 (FQ- @entity6884 ) in the prevention of early @entity2348 (EBIs) in liver transplant recipients (LTRs) is unknown. We used the online database of the Spanish Network of Infection in Transplantation/Spanish Network for Research in @entity166 , which prospectively analyzed 1010 LTRs from 12 Spanish hospitals from September 2003 to February 2005. We compared the incidence and etiology of EBIs (30 days after transplantation) in 415 LTRs from 4 centers that used FQ- @entity6884 (>7 days) and in 595 LTRs from 8 hospitals that did not use FQ- @entity6884 . A multivariate logistic regression analysis (including an adjustment for the transplant center factor) was performed to evaluate the potential protective factor of FQ- @entity6884 in the development of EBIs. We reported 266 EBI episodes in 252 LTRs (incidence = 24.9%). There were no differences in the incidence of EBIs between @entity1 in the FQ- @entity6884 group and @entity1 not in the FQ- @entity6884 group [109/415 (26.3%) versus 143/595 (24%), P = 0.9]. Although LTRs who received FQ- @entity6884 had a lower incidence of @entity281 due to enteric bacteria (2.7% versus 6.5%, P = 0.007) and a higher incidence of @entity281 due to nonfermenting gram-negative bacilli (6.6% versus 2.6%, P = 0.004), these findings could not be confirmed after an adjustment by the center factor in the multivariate models. We found no significant differences in the incidence of @entity281 (3.4% with FQ- @entity6884 versus 3.9% without FQ- @entity6884 , P = 0.5). Multivariate analysis did not confirm any protective effect of FQ- @entity6884 against the development of EBIs by enteric bacteria. In conclusion, FQ- @entity6884 does not reduce the incidence of EBIs in LTRs and could be withheld from this group of @entity1 .

title: Selective intestinal decontamination with XXXX for the prevention of early @entity2348 after liver transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['enterococcal infections', 'infections']

entities_list: @entity2887 :: ('MESH:D024841', 'Chemical') :: ['fluoroquinolones']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['Infectious Diseases']

answer: @entity2887 :: (MESH:D024841,Chemical) :: ['fluoroquinolones']


abstract: The role of selective intestinal decontamination with @entity2887 (FQ- @entity6884 ) in the prevention of early @entity2348 (EBIs) in liver transplant recipients (LTRs) is unknown. We used the online database of the Spanish Network of Infection in Transplantation/Spanish Network for Research in @entity166 , which prospectively analyzed 1010 LTRs from 12 Spanish hospitals from September 2003 to February 2005. We compared the incidence and etiology of EBIs (30 days after transplantation) in 415 LTRs from 4 centers that used FQ- @entity6884 (>7 days) and in 595 LTRs from 8 hospitals that did not use FQ- @entity6884 . A multivariate logistic regression analysis (including an adjustment for the transplant center factor) was performed to evaluate the potential protective factor of FQ- @entity6884 in the development of EBIs. We reported 266 EBI episodes in 252 LTRs (incidence = 24.9%). There were no differences in the incidence of EBIs between @entity1 in the FQ- @entity6884 group and @entity1 not in the FQ- @entity6884 group [109/415 (26.3%) versus 143/595 (24%), P = 0.9]. Although LTRs who received FQ- @entity6884 had a lower incidence of @entity281 due to enteric bacteria (2.7% versus 6.5%, P = 0.007) and a higher incidence of @entity281 due to nonfermenting gram-negative bacilli (6.6% versus 2.6%, P = 0.004), these findings could not be confirmed after an adjustment by the center factor in the multivariate models. We found no significant differences in the incidence of @entity281 (3.4% with FQ- @entity6884 versus 3.9% without FQ- @entity6884 , P = 0.5). Multivariate analysis did not confirm any protective effect of FQ- @entity6884 against the development of EBIs by enteric bacteria. In conclusion, FQ- @entity6884 does not reduce the incidence of EBIs in LTRs and could be withheld from this group of @entity1 .

title: Selective intestinal decontamination with @entity2887 for the prevention of early XXXX after liver transplantation.

answer: @entity2348 :: (MESH:D001424,Disease) :: ['bacterial infections']


abstract: @entity5642 is a @entity66 ; it is a rare subtype of @entity4812 characterized by the presence of @entity706 cells in the lumina of small vessels. A 49-year-old Caucasian @entity1 was admitted to the Department of Internal Medicine for fatigue, night sweats, loss of weight, and multiple nodules in the forearms. Three months ago the @entity1 's family noticed problems with her cognitive function, she displayed difficulties with common daily tasks. The neurological examination revealed bradypsychia. Laboratory data showed modestly high levels of @entity880 dehydrogenase, and @entity1851 . The day after admission, the @entity1 had @entity10 which raised in intensity; his mental status deteriorated, she was disoriented to time and place. She presented @entity2003 . The CSF examination revealed a hemorrhagic aspect, elements 30/mm3, cytology: lymphocytes 90%, numerous erythrocytes, proteinorachia 96 mg/dL, glycorrachia 60 mg/dL. Intravenous @entity1667 (0.5 g two times a day) and @entity2656 20% 1g/kgw/day were administered for five days without response. She became @entity772 and she died six days after hospitalization. The post-mortem macroscopical brain examination showed a swallen brain, with diffuse hemorrhagic areas in the supratentorial subcortical regions. Microscopical examination showed capillaries, venules, and many arterioles distended by large malignant cells suggesting malignant lymphocytes which were intraluminal. Every organ was involved, except for bone marrow and lymph nodes. Immunohistochemical studies showed intensive staining for B cells. and negative staining for factor VIII related antigen, a specific endothelial cell marker. @entity5642 was the post-mortem diagnostic. It represents a difficult diagnostic challenge which involves laboratory, imagistic and immunohistochemical investigations.

title: XXXX Presenting as Skin Lesions and Subacute Encephalopathy.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['Methylprednisolone']

entities_list: @entity2656 :: ('MESH:D008353', 'Chemical') :: ['Mannitol']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['nucal rigidity']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['neoplastic multisystemic disease']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity4812 :: ('MESH:D016403', 'Disease') :: ['diffuse large cell lymphoma']

entities_list: @entity772 :: ('MESH:D003128', 'Disease') :: ['comatose']

entities_list: @entity5642 :: ('MESH:D004211', 'Disease') :: ['Intravascular lymphomatosis']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity5642 :: (MESH:D004211,Disease) :: ['Intravascular Lymphomatosis']


abstract: OBJECTIVE: Catalase-peroxidase KatG can protect bacteria from damage of reactive @entity26 species. This study investigated the antioxidative function of catalase - peroxidase gene katG in @entity14441 3841. METHODS: katG mutant strain of @entity14441 was constructed by homologous recombination. The wild type, katG mutant and @entity6475 were challenged by oxidative stress and symbiotic ability. RESULTS: Under free - living conditions, the katG mutant exhibited no generation time extension. However, cells of the katG strain were @entity72585 oj high concentrations of @entity5568 and were vulnerable after aquick exposure to @entity5568 . The real-time qRT-PCR results showec that katG was expressed independently of exogenous @entity5568 . In contrast, the katG mutant strain displayed higher expres, level of ohrB gene and lower expression level of grxC than the wild type. With regard to symbiotic capacities with @entity3587 , the katG mutant was indistinguishable in root nodule nitrogenase activity and competition nodule ability from the wild type. However, katG gene was expressed significantly lower in bacteroids than that in free-living strains. Besides, the colonization of the @entity3587 rhizosphere by the katG mutant was impaired compared to that of the wild type. CONCLUSION: ThE deletion of katG had nosignificant effect in 3841 under the free-living and symbiosis condition but was essential ir antioxidation and colonization of the @entity3587 rhizosphere. Although katG could not be induced by @entity5568 , it still played acentra role in antioxidation and symbiotic @entity1568 fixation by regulating the antioxidant genes such as ohrB and grxC.

title: [Antioxidative function of katG gene in XXXX ].

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity14441 :: ('384', 'Species') :: ['R. leguminosarum', 'Rhizobium leguminosarum']

entities_list: @entity6475 :: ('MESH:D013180', 'Disease') :: ['complementary strain']

entities_list: @entity72585 :: ('MESH:C563120', 'Disease') :: ['deficient in consumption']

entities_list: @entity3587 :: ('3888', 'Species') :: ['Pisum sativum', 'pea']

answer: @entity14441 :: (384,Species) :: ['Rhizobium leguminosarum']


abstract: PURPOSE: To investigate combined immunosuppressive therapy with @entity1891 , @entity1667 , and prolonged @entity205 in adolescents with refractory @entity3039 ( @entity3039 ). @entity1 AND METHODS: Ten adolescent @entity1 with @entity3039 refractory to previous medical management, including gluco-corticosteroid, intravenous immunoglobulin or anti-Rh (D) IgG, or splenectomy, were treated with combination immunosuppressive therapy at the University of Michigan between 1997 and 2001. Therapy consisted of weekly doses of @entity1891 1.5 mg/m intravenous push (IVP) (maximum dose 2 mg), weekly @entity1667 100 mg/m IVP, and @entity205 (CSA) 5 mg/kg orally twice daily (goal: CSA trough of 100-200 mg/mL). @entity1891 and @entity1667 were given weekly until the platelet count was greater than 50,000/mm for a minimum of 2 doses and a maximum of 4 doses. CSA was continued until the platelet count was normal for 3 to 6 months. RESULTS: Seven @entity1 had continuous complete responses (platelet count normal after cessation of CSA), a median of 13 months (9-37 months) since completion of therapy. One @entity1 had a partial response (platelet count 80-120 x 10 /L off CSA for 3 months). Two @entity1 were nonresponders (platelet count <40 x 10 /L), one of whom had all therapy discontinued after 2 weeks due to @entity1897 . The median time to response was 7 days (range 7-67 days). CSA was administered for a median of 4 months (range 0.5-19 months). CONCLUSIONS: A combination immunosuppressive approach that includes prolonged @entity205 therapy may be promising for refractory @entity3039 and is associated with sustained disease remissions in some @entity1 .

title: Combination therapy for refractory XXXX in adolescents.

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['Vincristine', 'vincristine']

entities_list: @entity3039 :: ('MESH:D016553', 'Disease') :: ['ITP', 'idiopathic thrombocytopenic purpura']

answer: @entity3039 :: (MESH:D016553,Disease) :: ['idiopathic thrombocytopenic purpura']


abstract: OBJECTIVE: To discuss the feasibility, safety and effectiveness of surgical management of post @entity2998 ( @entity2998 ) @entity256 , mainly focusing on the surgical options and indications. METHODS: This study represented retrospective analysis of 3 kinds of surgical managements of 21 @entity1 with symptomatic @entity2998 from April 2012 to April 2014. Patch carotid endarterectomy (pCEA), Eversion carotid endarterectomy (eCEA) or carotid excision and graft interposition (CEGI) was selected to remove the stent and reconstruct the blood flow, based on the preoperative imaging results and intraoperative adhesion degree. Use of carotid shunt, @entity190 , operative time, carotid artery cross-clamp time and other data were recorded. @entity1 were followed for improvement of symptoms, complications and @entity256 . RESULTS: Eleven, 4 and 6 @entity1 received pCEA, eCEA or CEGI respectively. All the stents were successfully removed. Shunts were deployed in 14 cases. The mean bleeding was (152.6    38.0) ml, the mean operation time was (100.7    34.8) min and the mean carotid artery clamping time was (29.1    4.6) min. In the early postoperative period, there were no infection, @entity64 , @entity128 , @entity583 or mortalities. One @entity1 developed @entity135 , while 2 @entity1 had the symptoms of hyperperfusion such as @entity10 , @entity146 and multi-lingual but no @entity932 happened according to the brain CT scan, who all fully recovered within 3 days. Within a median follow-up of (13.2    4.3) months, no @entity64 , @entity583 or recurrent @entity256 (> 50%) on duplex ultrasound imaging or CTA was discovered except for 1 @entity1 who died of @entity2 . CONCLUSION: Surgical management to remove the stent and reconstruct the blood flow, which offered new options in the treatment of @entity2998 , with its initially confirmed simplicity, feasibility, safety and validity.

title: [Surgical management of post @entity2998 XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['neck hematoma']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['irritability']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['post CAS restenosis', 'carotid artery stenting', 'CAS']

entities_list: @entity256 :: ('MESH:D023903', 'Disease') :: ['restenosis']

entities_list: @entity128 :: ('MESH:D020209', 'Disease') :: ['cranial nerve injury']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'myocardial infarctions']

answer: @entity256 :: (MESH:D023903,Disease) :: ['restenosis']


abstract: OBJECTIVE: To discuss the feasibility, safety and effectiveness of surgical management of post @entity2998 ( @entity2998 ) @entity256 , mainly focusing on the surgical options and indications. METHODS: This study represented retrospective analysis of 3 kinds of surgical managements of 21 @entity1 with symptomatic @entity2998 from April 2012 to April 2014. Patch carotid endarterectomy (pCEA), Eversion carotid endarterectomy (eCEA) or carotid excision and graft interposition (CEGI) was selected to remove the stent and reconstruct the blood flow, based on the preoperative imaging results and intraoperative adhesion degree. Use of carotid shunt, @entity190 , operative time, carotid artery cross-clamp time and other data were recorded. @entity1 were followed for improvement of symptoms, complications and @entity256 . RESULTS: Eleven, 4 and 6 @entity1 received pCEA, eCEA or CEGI respectively. All the stents were successfully removed. Shunts were deployed in 14 cases. The mean bleeding was (152.6    38.0) ml, the mean operation time was (100.7    34.8) min and the mean carotid artery clamping time was (29.1    4.6) min. In the early postoperative period, there were no infection, @entity64 , @entity128 , @entity583 or mortalities. One @entity1 developed @entity135 , while 2 @entity1 had the symptoms of hyperperfusion such as @entity10 , @entity146 and multi-lingual but no @entity932 happened according to the brain CT scan, who all fully recovered within 3 days. Within a median follow-up of (13.2    4.3) months, no @entity64 , @entity583 or recurrent @entity256 (> 50%) on duplex ultrasound imaging or CTA was discovered except for 1 @entity1 who died of @entity2 . CONCLUSION: Surgical management to remove the stent and reconstruct the blood flow, which offered new options in the treatment of @entity2998 , with its initially confirmed simplicity, feasibility, safety and validity.

title: [Surgical management of post XXXX @entity256 ].

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity2998 :: (MESH:D002340,Disease) :: ['carotid artery stenting']


abstract: OBJECTIVES: To investigate the effect of some epidemiological and radiologic factors on the outcome of prosthetic replacement in acute proximal humerus @entity174 . DESIGN: Retrospective clinical study. @entity1 : Thirty-two @entity1 [mean age 58 (range 37-83 years)] with a mean follow-up period of 35 months (range 8-80 months). Fifteen cases had Neer type IV, 2 had type III, and 15 @entity1 had @entity174 . MAIN OUTCOME MEASUREMENTS: Neer's criteria, Constant score, and elevation degree were used. Radiological parameters were union and position of the tuberosities, bone stock, and position of the prosthesis. RESULTS: Excellent or good results according to Neer's criteria were obtained in 24 of the 32 cases (75%), and unsatisfactory results in 8 cases (25%). Mean Constant score was 68 (range 19-98) and mean elevation degree 113 (range 30-180). Thirty-one cases (97%) had no or mild @entity158 . Cases operated within 14 days following injury had a better general outcome (p = 0.005). The humeral offset was directly correlated to the elevation degree (p = 0.011) and Constant score (p = 0.002), whereas the head height was inversely correlated to the same parameters (p = 0.001 for both). The cutoff point for the humeral offset-general outcome correlation was calculated as 23 mm using ROC curve analysis. The most common complications were problems concerning the tuberosities (50%), and they adversely affected the clinical outcome (p = 0.002). CONCLUSIONS: Preoperative delay, problems of tuberosity fixation, and position of the tuberosities were parameters influencing the clinical outcome. Lateralization of the tuberosities results in better scores, whereas their distal transfer can be related to a poorer outcome.

title: Prognostic factors in prosthetic replacement for acute proximal humerus XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture-dislocations']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: It has been suggested that a poor prognosis and the development of @entity1778 in @entity1 with @entity2590 may be related to @entity2008 . We measured the DNA content of bone marrow cells with flow cytometry in 19 hematologically normal subjects and in 70 @entity1 who had recently been diagnosed as having @entity2590 . Thirty-four of the @entity1 were found to have @entity2007 . This was not related to the percentage of blast cells in the bone marrow, and there was no demarcation in terms of DNA content between @entity1 with a high percentage of blast cells and those with a low percentage of such cells. @entity1 with @entity236 had a significantly shorter survival time than other @entity1 (P = 0.001). @entity1 with @entity981 marrow and those whose marrow had a normal DNA content had similar survival times. Hypodiploidy appears to be a better indicator of poor survival than the marrow blast-cell count. @entity1 with @entity417 invariably had cells with a normal or high DNA content; none of these @entity1 died during the study. Our data suggest that there is a relation between the loss of chromosomal material and progression toward a @entity1778 phenotype. It is tempting to speculate that this process may involve a loss of negative regulatory genes ("anti-oncogenes").

title: Prognostic importance of hypodiploid hemopoietic precursors in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['hyperdiploid']

entities_list: @entity417 :: ('MESH:D000740', 'Disease') :: ['sideroblastic anemia']

entities_list: @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplasia']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['hypodiploid marrow cells']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukemia', 'leukemic']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormalities']

answer: @entity2590 :: (MESH:D009190,Disease) :: ['myelodysplastic syndromes']


abstract: Massive @entity2479 , a nonneoplastic retinal glial proliferation, was first described in detail over 25  years ago, before the era of immunohistochemistry, in a series of 38 cases-to which can be added 30 case reports or small series (no more than 3 cases) subsequently. We analyze a new series of 3 nontumoral intraretinal glioses and 15 cases of @entity12621 , not all of which, strictly speaking, were massive. The data from this series are compared with the findings in previously published cases. Included are 2 cases of massive @entity2479 diagnosed from evisceration specimens. In reviewing all published and current cases, we were able to establish 3 subgroups of retinal tumoral glioses rather than a single "massive" category: focal nodular @entity5219 , @entity5219 , and massive @entity5219 . Among 43 reported cases, including the present series, but excluding the previous large series of 38 cases in which substantial clinical data were omitted, there were 19 @entity1 and 24 @entity1 . Their mean and median ages were 36.2  years and 36  years, respectively, with a range of 2 to 79  years. All lesions were composed of mitotically quiet, compact spindled fibrous astrocytes devoid of an Alcian blue-positive myxoid matrix. The most common associated ocular conditions were phthisis bulbi and @entity66 or @entity600 . Histopathologically, all 3 tumoral categories were accompanied by progressively more extensive fibrous and osseous metaplasia of the pigment epithelium, the latter forming a clinically and diagnostically useful, almost continuous, outer rim of eggshell @entity730 in the submassive and massive categories that should be detectable with appropriate imaging studies. In decreasing order of frequency, microcysts and macrocysts, @entity455 , exudates, calcospherites, and Rosenthal fibers were observed among the proliferating fibrous astrocytes. Immunohistochemistry was positive for glial fibrillary acidic protein in all cases and nestin in most (an intermediate cytoplasmic filament typically restricted to embryonic and reparative neural tissue). The nonneoplastic nature of all categories of @entity5219 was confirmed by absent @entity876 ( @entity5 suppressor gene) dysregulation, Ki-67 negativity, and intact @entity986 expression (the protein product of the @entity986 @entity5 suppressor gene) in the overwhelming majority of cases. These findings indicate an intrinsic attempt to regulate and maintain a low level of glial cell proliferation that becomes unsuccessful as the disease evolves. The categories of tumoral proliferation appeared to constitute a spectrum. We conclude that focal @entity5 encompass lesions previously called retinal vasoproliferative lesions, which display the same histopathologic and immunohistochemical findings as 3 major categories of @entity2479 characterized herein.

title: So-called massive XXXX : A critical review and reappraisal.

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular sclerosis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['congenital diseases']

entities_list: @entity2479 :: ('MESH:D012173', 'Disease') :: ['retinal gliosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'nodular tumors']

entities_list: @entity5219 :: ('MESH:D005911', 'Disease') :: ['gliosis', 'submassive gliosis']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity12621 :: ('MESH:D019572', 'Disease') :: ['tumoral retinal gliosis']

answer: @entity2479 :: (MESH:D012173,Disease) :: ['retinal gliosis']


abstract: BACKGROUND: Detachment of the septal leaflet of the tricuspid valve has been described for better access to perimembranous @entity1757 . Detachment confined to the anterior leaflet is less known, although it provides a better exposure of the subaortic area and puts less jeopardy on the conduction tissues. METHODS: Data regarding 49 consecutive @entity1 who had congenital perimembranous @entity1757 closure were retrospectively reviewed. Thirty-three @entity1 (67%) underwent temporary detachment of the anterior leaflet of the tricuspid valve. The defect was closed with a Gore-Tex patch and a continuous suture. In 10 @entity1 (29%), concomitant right ventricular outflow tract enlargement was performed. Follow-up was obtained in every @entity1 (median time, 11 months; range, 2 to 26 months). RESULTS: No early or late @entity204 occurred. Closure of the @entity1757 was complete, with no more than trivial residual jet leaks found in perioperative echocardiography. All @entity1 were in sinus rhythm. The tricuspid valve never showed more than mild insufficiency after repair. No @entity1 showed @entity3888 . CONCLUSIONS: Detachment of the anterior leaflet of the tricuspid valve to expose the @entity1757 is a safe approach that allows rapid closure of the defect with a continuous suture and provides excellent results.

title: Detachment of the anterior leaflet of the tricuspid valve to expose perimembranous XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septal defects', 'ventricular septal defect']

entities_list: @entity3888 :: ('MESH:D011662', 'Disease') :: ['subaortic obstruction']

answer: @entity1757 :: (MESH:D006345,Disease) :: ['ventricular septal defects']


abstract: The authors present a case with a @entity1756 of the @entity2694 and the coexisting @entity254 with the @entity6128 , accompanied by @entity510 and @entity1779 in the @entity75 . A 44-year-old male, whose past history had been uneventful, was admitted complaining severe @entity10 and @entity391 , followed by @entity911 . CT examinations revealed @entity510 and @entity1779 in the @entity75 . Left carotid angiograms disclosed a @entity439 described above. Emergency operation in a state of grade 3 according to Hunt and Kosnik revealed a @entity439 and its parent artery which was thought to be proximally a @entity2694 and distally a @entity6128 , which was seen to penetrate the anterior cranial fossa at the lamina cribrosa. Then the @entity439 was excised following clipping of the neck. Thereafter, the @entity1 showed favorable recovery. The histological examination revealed absence of the media and the internal elastic lamina in the wall of the @entity439 with slight infiltration of round cells. Generally speaking, distal anterior cerebral @entity438 , which arise on branches beyond the anterior communicating artery, occupy 2-5% of all @entity438 , and most of them are found at the branching site of the pericallosal artery. As far as the authors know, there was few or no report referring to the @entity439 arising on the fronto-orbital artery, as shown in this case. Also, as for the @entity439 arising on the anterior ethmoidal artery, there are a few reports.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A @entity438 and a coexisting XXXX with the anterior ethmoidal artery--a case report].

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['left frontal lobe']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['artery aneurysms', 'cerebral aneurysms']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity2694 :: ('MESH:D009916', 'Disease') :: ['left fronto-orbital artery']

entities_list: @entity6128 :: ('MESH:D020243', 'Disease') :: ['left anterior ethmoidal artery']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['saccular aneurysm', 'aneurysm']

entities_list: @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hematoma']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured saccular aneurysm']

answer: @entity254 :: (MESH:C563598,Disease) :: ['anastomosis']


abstract: The authors present a case with a @entity1756 of the @entity2694 and the coexisting @entity254 with the @entity6128 , accompanied by @entity510 and @entity1779 in the @entity75 . A 44-year-old male, whose past history had been uneventful, was admitted complaining severe @entity10 and @entity391 , followed by @entity911 . CT examinations revealed @entity510 and @entity1779 in the @entity75 . Left carotid angiograms disclosed a @entity439 described above. Emergency operation in a state of grade 3 according to Hunt and Kosnik revealed a @entity439 and its parent artery which was thought to be proximally a @entity2694 and distally a @entity6128 , which was seen to penetrate the anterior cranial fossa at the lamina cribrosa. Then the @entity439 was excised following clipping of the neck. Thereafter, the @entity1 showed favorable recovery. The histological examination revealed absence of the media and the internal elastic lamina in the wall of the @entity439 with slight infiltration of round cells. Generally speaking, distal anterior cerebral @entity438 , which arise on branches beyond the anterior communicating artery, occupy 2-5% of all @entity438 , and most of them are found at the branching site of the pericallosal artery. As far as the authors know, there was few or no report referring to the @entity439 arising on the fronto-orbital artery, as shown in this case. Also, as for the @entity439 arising on the anterior ethmoidal artery, there are a few reports.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A XXXX and a coexisting @entity254 with the anterior ethmoidal artery--a case report].

answer: @entity438 :: (MESH:D002532,Disease) :: ['ruptured cerebral aneurysm of the fronto-orbital artery']


abstract: Four cases of @entity932 associated with pregnancy are reported. They were a @entity397 anterior communicating @entity439 , a @entity397 of cerebellar hemisphere, a lt-thalamic and @entity6658 and @entity932 . As the mode of @entity548 , one case was a @entity510 , one case was a @entity510 combined with a @entity548 and other two cases were @entity548 . The mean age of these 4 cases was 29.5 years of age from 25 to 35. One case was occurred the @entity932 during the first trimester but other 3 cases was occurred during the third trimester. It was, thus, considered the @entity932 associated with pregnancy was more frequently occurred during the third trimester. Primigravida and multigravida were equally occurred on each two cases. It was not related to parity. Consciousness levels were drowsiness; one case, semicoma; two cases and deep @entity772 ; one case. A case of @entity397 anterior communicating @entity439 underwent neck clipping of @entity439 through the rt-fronto-temporal craniotomy on the first day of the attack. This case fully recovered, but the other three cases of severely impaired consciousness level were dead. Maternal prognosis was related to consciousness level. We mentioned the preferred neurosurgical and obstetrical management to the @entity932 associated with pregnancy.

title: [Intracranial XXXX associated with pregnancy--4 case reports and a review of the literature].

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['brain stem hemorrhage', 'intracranial hemorrhage']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intraparenchymal hemorrhage', 'hemorrhage', 'cerebellar hemorrhage']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['ruptured', 'ruptured AVM']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm']

entities_list: @entity6658 :: ('MESH:D020146', 'Disease') :: ['putaminal hemorrhage']

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhage']


abstract: The @entity1 was a 52-year-old @entity1 who was initially admitted to our hospital with a recent history of @entity892 , @entity1736 and @entity227 on the right, adding to 6 years history of the right orbital @entity158 . She had gradually developed @entity158 and fatigue of the right knee since childhood and had been suffered from multiple subcutaneous @entity5 in the both hands and the right foot from youth onward. On neurological examination, she has had right exphthalmos and 3rd and 6th @entity129 on the right. Skull X-ray and CT scan showed parasellar calcified mass on the right. In chromosome examination, the inversion of the No. 1 chromosome was disclosed by the Q- and C-band dyeing of her leucocytes and skin culture. @entity2477 of her @entity272 and @entity75 were diagnosed by X-ray examination and histological specimen, indicating so-called @entity6446 . One year and a half later, she was readmitted to our institution, because of progressive @entity227 on the right and left @entity1269 . @entity66 was suspected by the clinical course and neuroradiological findings and was confirmed histologically by the second peration. During postoperative course, intratumoral @entity548 had occurred twice and the @entity1 died, and postmortem examination confirmed her clinical affair. This is the case which was clarified @entity5 in the parasellar region, and is the first case verified the @entity2008 in @entity6446 .

title: [ XXXX with intracranial manifestation and @entity2008 --a case report].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve palsies']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss', 'visual impairment']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosome abnormalities']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Malignant change of the parasellar lesion']

entities_list: @entity2477 :: ('MESH:D006392', 'Disease') :: ['Cavernous hemangioma']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant transformation of enchondroma']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['enchondroma of the skeletal lesion']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain and temporal headache', 'pain']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesion']

entities_list: @entity892 :: ('MESH:D004172', 'Disease') :: ['diplopia']

entities_list: @entity6446 :: ('MESH:D004687', 'Disease') :: ["Maffucci's syndrome"]

answer: @entity6446 :: (MESH:D004687,Disease) :: ['Maffucci's syndrome']


abstract: The @entity1 was a 52-year-old @entity1 who was initially admitted to our hospital with a recent history of @entity892 , @entity1736 and @entity227 on the right, adding to 6 years history of the right orbital @entity158 . She had gradually developed @entity158 and fatigue of the right knee since childhood and had been suffered from multiple subcutaneous @entity5 in the both hands and the right foot from youth onward. On neurological examination, she has had right exphthalmos and 3rd and 6th @entity129 on the right. Skull X-ray and CT scan showed parasellar calcified mass on the right. In chromosome examination, the inversion of the No. 1 chromosome was disclosed by the Q- and C-band dyeing of her leucocytes and skin culture. @entity2477 of her @entity272 and @entity75 were diagnosed by X-ray examination and histological specimen, indicating so-called @entity6446 . One year and a half later, she was readmitted to our institution, because of progressive @entity227 on the right and left @entity1269 . @entity66 was suspected by the clinical course and neuroradiological findings and was confirmed histologically by the second peration. During postoperative course, intratumoral @entity548 had occurred twice and the @entity1 died, and postmortem examination confirmed her clinical affair. This is the case which was clarified @entity5 in the parasellar region, and is the first case verified the @entity2008 in @entity6446 .

title: [ @entity6446 with intracranial manifestation and XXXX --a case report].

answer: @entity2008 :: (MESH:D002869,Disease) :: ['chromosome abnormalities']