abstract: OBJECTIVES: Although the importance of stretching exercise for @entity158 -relieving and @entity1 education is well documented for chronic lumbago @entity1 , it is uncertain how effective on-the-job training (OJT) is for female caregivers in nursing homes. In the present pilot trial based on multicenter randomization, we evaluated the intervention effect of a lecture and stretching exercise on caregivers in nursing homes. METHODS: Eighty-eight female caregivers (four nursing homes) volunteered to participate in this study, and they were separated into two groups randomly. For the intervention group, guidance by an orthopedist and an exercise instructor were provided as one OJT, and stretching exercises for only 6 min every day were recommended for @entity1643 prevention to the caregivers. @entity1643 visual analogue scale (VAS), physical fitness, and mental and physical health were compared at baseline and immediately after the intervention. RESULTS: A total of 29 (33%) @entity1 withdrew by 12 weeks. Regarding the reasons for withdrawal, 28 @entity1 resigned, and one took a leave of absence due to exacerbation of lumbago. Adherence to the stretching exercises was 2.3    1.3 (mean    SD) times per week. No significant differences were seen for any outcome measurements. The high adherence group (   3 times per week) did not show a change in the VAS, but the low adherence group (<3 times per week) and control group showed a tendency towards an increased score (p = 0.068). CONCLUSIONS: Even with the conduct of one OJT, and exercises of only 6 min every day, the adherence of caregivers was low, and there appeared to be few effects of the OJT.

title: Effectiveness of intervention for XXXX in female caregivers in nursing homes: a pilot trial based on multicenter randomization.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['Low back pain', 'low back pain']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['low back pain']


abstract: OBJECTIVES: The purposes of this paper were to evaluate the serum @entity1243 levels in healthy adolescents and to establish standard age variation curves. METHODS: Nine hundred six (414 @entity1 and 492 @entity1 ) healthy adolescents were investigated. The maximum increment age in height (MIA) was identified in 124 @entity1 and 130 @entity1 . The menarcheal age (MA) was obtained for 130 @entity1 . Fasting @entity1243 levels were measured by enzyme immunoassay. The MIA was calculated by proportional allotment of yearly height increments. RESULTS: Serum @entity1243 levels did not change in @entity1 and @entity1 from the ages of 9 to 11. They decreased after the age of 11 in @entity1 , while they increased in @entity1 . Stepwise multiple regression analysis revealed that serum @entity1243 levels were closely related to pubertal stage. The levels decreased remarkably after MIA in @entity1 and increased remarkably after MA in @entity1 . We drew standard age variation curves of serum @entity1243 levels by calculating the 25th, 50th and 75th percentiles for each age in both @entity1 and @entity1 . The percentile curves for @entity1 were divided into pre-MIA and post-MIA curves. Those for @entity1 were divided into pre-MA and post-MA curves. CONCLUSION: We have devised a potentially useful method for evaluating serum @entity1243 levels in adolescents considering the effects of gender and growth.

title: Serum XXXX levels in healthy adolescents: Effects of gender and growth.

answer: @entity1243 :: (3952,Gene) :: ['leptin']


abstract: OBJECTIVE: To identify apoptosis in @entity1641 intestines and determine whether apoptosis is associated with @entity344 or a specific tissue layer of intestine. ANIMALS: 38 @entity1641 that underwent surgery or were euthanatized for small or large @entity1321 and 9 control @entity1641 euthanatized for reasons other than @entity344 or @entity262 . PROCEDURE: Specimens were collected at surgery from intestine involved in the @entity75 and distant to the @entity75 site or at necropsy from several sites including the @entity75 site. Histologic tissue sections were stained with H_E, and apoptosis was detected by use of the terminal deoxynucleotidyl transferase-mediated @entity1977 nick end labeling technique. The number of apoptotic cells per hpf was counted in the mucosa, circular muscle, longitudinal muscle, and serosa. RESULTS: Apoptotic nuclei were seen in all layers of intestine. An increased number of apoptotic cells was found in the circular muscle of the intestine from @entity1641 with simple obstruction, compared with strangulating obstruction or healthy intestine. Intestine distant from a primary strangulating lesion had higher numbers of apoptotic cells than did intestine distant from a @entity75 or intestine taken at the site of a strangulating or @entity75 . CONCLUSIONS AND CLINICAL RELEVANCE: Intestine from @entity1641 with obstructing or strangulating lesions in the small intestine and large colon had high numbers of apoptotic cells possibly because of @entity2806 and subsequent @entity32 . Whether substantial apoptosis affects intestinal function is not yet known.

title: Detection of apoptotic cells in intestines from @entity1641 with and without XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['ischemic cell injury']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['simple obstructive lesion', 'primary lesion']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal tract disease']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestine obstruction, strangulation, or distension']

answer: @entity344 :: (MESH:D005767,Disease) :: ['gastrointestinal tract disease']


abstract: OBJECTIVE: To identify apoptosis in @entity1641 intestines and determine whether apoptosis is associated with @entity344 or a specific tissue layer of intestine. ANIMALS: 38 @entity1641 that underwent surgery or were euthanatized for small or large @entity1321 and 9 control @entity1641 euthanatized for reasons other than @entity344 or @entity262 . PROCEDURE: Specimens were collected at surgery from intestine involved in the @entity75 and distant to the @entity75 site or at necropsy from several sites including the @entity75 site. Histologic tissue sections were stained with H_E, and apoptosis was detected by use of the terminal deoxynucleotidyl transferase-mediated @entity1977 nick end labeling technique. The number of apoptotic cells per hpf was counted in the mucosa, circular muscle, longitudinal muscle, and serosa. RESULTS: Apoptotic nuclei were seen in all layers of intestine. An increased number of apoptotic cells was found in the circular muscle of the intestine from @entity1641 with simple obstruction, compared with strangulating obstruction or healthy intestine. Intestine distant from a primary strangulating lesion had higher numbers of apoptotic cells than did intestine distant from a @entity75 or intestine taken at the site of a strangulating or @entity75 . CONCLUSIONS AND CLINICAL RELEVANCE: Intestine from @entity1641 with obstructing or strangulating lesions in the small intestine and large colon had high numbers of apoptotic cells possibly because of @entity2806 and subsequent @entity32 . Whether substantial apoptosis affects intestinal function is not yet known.

title: Detection of apoptotic cells in intestines from XXXX with and without @entity344 .

answer: @entity1641 :: (9796,Species) :: ['horses']


abstract: BACKGROUND: The type of surgical antimicrobial prophylaxis (SAP) is determined by the spectrum and antimicrobial resistance of pathogens causing surgical site @entity281 (SSI). The aim of this study was to define the microbiological features of SSI in general surgery @entity1 at Basel University Hospital in order to validate our current strategy of single-shot SAP with 1.5 g @entity2261 (plus 500 mg @entity868 in colorectal surgery). METHODS: A prospective observational cohort of consecutive vascular, visceral and @entity130 procedures was analysed to evaluate the incidence of SSI. @entity6081 and resulting @entity281 were assessed to centres for disease control standards. Microbiological evaluation was performed by microscopic direct preparation, cultures and testing for antibiotic resistance. RESULTS: A total of 293 instances of SSI were detected in this cohort of 6283 surgical procedures (4.7%). Microbiological species were identified in 129 of 293 SSI (44%). @entity794 (29.5%) was the most common pathogen causing SSI in @entity130 and vascular surgery, whereas @entity526 (20.9%) was more frequently responsible for SSI in visceral surgery. Importantly, not a single case of SSI was caused by antimicrobial-resistant pathogens in this series. CONCLUSIONS: The spectrum of pathogens causing SSI identified and the very low incidence of antimicrobial resistance at Basel University Hospital validate the continuous use of single-shot single-drug SAP with @entity2261 (plus @entity868 in colorectal surgery).

title: Spectrum of pathogens in surgical site XXXX at a Swiss university hospital.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2261 :: ('MESH:D002444', 'Chemical') :: ['cefuroxime']

entities_list: @entity6081 :: ('MESH:D013530', 'Disease') :: ['Surgical wounds']

entities_list: @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infections']


abstract: BACKGROUND: Palliative resection of the primary @entity5 in asymptomatic @entity1 with stage IV @entity14 is associated with improved survival and fewer complications. Laparoscopic surgery is widely employed in the curative treatment of @entity14 , but its value in advanced @entity14 remains unclear. METHODS: All @entity1 who underwent laparoscopic resection of primary @entity14 in this unit between June 1991 and Jan 2010 were entered into a prospective computerized database. Outcomes for @entity1 with laparoscopic resection of stage IV @entity14 were compared with those of @entity1 who had laparoscopic surgery for stage I disease. RESULTS: Some 185 @entity1 with stage IV @entity14 who underwent laparoscopic resection were compared with 310 @entity1 who had stage I @entity14 . Some 94  1 and 98  4 per cent of operations respectively were completed laparoscopically. Hospital stay was slightly longer in the group with stage IV disease (mean 6  2 versus 5  3 days; P = 0  091). The 30-day mortality rate was 2  7 per cent in @entity1 with stage IV disease and 0  6 per cent in those with @entity5 (P = 0  061). There was no difference in complications. One-year survival rates were 77  8 and 99  0 per cent respectively (P < 0  001). CONCLUSION: Short-term outcomes after laparoscopic surgery for stage IV @entity14 in selected @entity1 are equivalent to those for @entity5 .

title: Laparoscopic resection of advanced XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage I tumours', 'stage I cancers', 'tumour']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: OBJECTIVE: To examine the role of mast cells (MCs), cytokines, and matrix metalloproteinases (MMPs) following ultraviolet B (UVB) radiation in @entity3830 ( @entity3830 ). METHODS: Immunohistochemistry was used to determine the presence of MCs and the expression of @entity3334 , @entity1495 , @entity8252 , and @entity5737 / @entity5737 in skin from @entity1 with @entity3830 . @entity1 keratinocytes were exposed to varying doses of UVB and supernatants were collected and assessed for @entity8252 , @entity5737 , @entity3334 , and @entity1495 by protein assays. MC migration was determined against supernatants from UVB-treated keratinocytes. RESULTS: MCs in the skin of @entity1 with @entity3830 were significantly increased. @entity3334 and @entity1495 expression was abundant in these lesions. Intense reactivity for @entity8252 and @entity5737 was found in skin, particularly in epidermal keratinocytes, from @entity1 with @entity3830 . UVB irradiation induced @entity8252 , @entity5737 , @entity3334 , and @entity1495 production from keratinocytes in a dose- and time-dependent manner. Supernatants obtained from UVB-treated keratinocytes induced MC migration, which was attenuated by anti- @entity8252 and anti- @entity5737 neutralizing antibodies. @entity8252 induced MC-derived MMP production. CONCLUSIONS: Our results indicate that MCs and MMPs may play a role in the @entity32 in @entity3830 . MC recruitment as well as MMP production may be perpetuated by UV irradiation through locally released mediators.

title: Ultraviolet radiation-induced cytokines promote mast cell accumulation and matrix metalloproteinase production: potential role in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Human']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['skin inflammation']

entities_list: @entity3830 :: ('MESH:D008178', 'Disease') :: ['cutaneous lupus erythematosus', 'CLE']

answer: @entity3830 :: (MESH:D008178,Disease) :: ['cutaneous lupus erythematosus']


abstract: BACKGROUND: Although crustaceans have been reported to be one of the most common causes of IgE-mediated @entity56 , there are no reports about the characterization and identification of @entity369 kinase ( @entity54558 ) from the @entity8389 ( @entity8389 ) as allergen. In the present study, the purification, molecular cloning, expression and immunological analyses of the IgE allergen @entity54558 from the @entity8389 were investigated. RESULTS: The results showed that cloned DNA fragments of @entity54558 from the @entity8389 had open reading frames of 1021 bp, predicted to encode proteins with 356 @entity535 residues. Sequence alignment revealed that @entity8389 @entity54558 shares high homology with other crustacean species. @entity8389 @entity54558 gene was further recombined with the vector of pGEX-4T-3 and expressed in @entity13724 . 2-D electrophoresis suggested that native @entity54558 (nAK) and recombinant @entity54558 ( @entity54558 ) shared the same molecular weight of 40 kDa, and the pI is 6.5 and 6.3, respectively. The nAK and @entity54558 were further confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Immunoblotting analysis and colloidal gold immunochromatographic assay (GICA) using sera from subjects with crustacean @entity566 confirmed that the nAK and @entity54558 reacted positively with these sera, indicating @entity54558 is a specific allergen of @entity8389 . CONCLUSION: Both of purified nAK and @entity54558 reacted positively with sera from subjects with crustacean @entity566 in immunoblotting and GICA analysis, indicating @entity54558 is a common allergen of @entity8389 . In vitro expressed @entity54558 is proposed as a source of the protein for immunological or clinical studies.

title: Purification, cloning, expression and immunological analysis of XXXX @entity369 kinase, the crab allergen.

entities_list: @entity8389 :: ('6761', 'Species') :: ['Scylla serrata', 'mud crab', 'Mud crab']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic reactions']

entities_list: @entity13724 :: ('511693', 'Species') :: ['Escherichia coli BL 21']

entities_list: @entity369 :: ('CHEBI:29016', 'Chemical') :: ['arginine']

answer: @entity8389 :: (6761,Species) :: ['Scylla serrata']


abstract: BACKGROUND: Although crustaceans have been reported to be one of the most common causes of IgE-mediated @entity56 , there are no reports about the characterization and identification of @entity369 kinase ( @entity54558 ) from the @entity8389 ( @entity8389 ) as allergen. In the present study, the purification, molecular cloning, expression and immunological analyses of the IgE allergen @entity54558 from the @entity8389 were investigated. RESULTS: The results showed that cloned DNA fragments of @entity54558 from the @entity8389 had open reading frames of 1021 bp, predicted to encode proteins with 356 @entity535 residues. Sequence alignment revealed that @entity8389 @entity54558 shares high homology with other crustacean species. @entity8389 @entity54558 gene was further recombined with the vector of pGEX-4T-3 and expressed in @entity13724 . 2-D electrophoresis suggested that native @entity54558 (nAK) and recombinant @entity54558 ( @entity54558 ) shared the same molecular weight of 40 kDa, and the pI is 6.5 and 6.3, respectively. The nAK and @entity54558 were further confirmed by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Immunoblotting analysis and colloidal gold immunochromatographic assay (GICA) using sera from subjects with crustacean @entity566 confirmed that the nAK and @entity54558 reacted positively with these sera, indicating @entity54558 is a specific allergen of @entity8389 . CONCLUSION: Both of purified nAK and @entity54558 reacted positively with sera from subjects with crustacean @entity566 in immunoblotting and GICA analysis, indicating @entity54558 is a common allergen of @entity8389 . In vitro expressed @entity54558 is proposed as a source of the protein for immunological or clinical studies.

title: Purification, cloning, expression and immunological analysis of @entity8389 XXXX kinase, the crab allergen.

answer: @entity369 :: (CHEBI:29016,Chemical) :: ['arginine']


abstract: BACKGROUND: In the emergency management of @entity1 with @entity174 , there is ongoing debate about the roles of angiography and open pelvic packing. It is agreed that some form of @entity548 control is required for @entity1 who are haemo-dynamically unstable despite resuscitation. We set out to determine whether on-call general and orthopaedic surgeons would feel able to perform emergency surgical procedures for these @entity1 and whether vascular radiology was available to them. METHODS: Surveys were sent to all 221 general and orthopaedic surgeons in Wales. Questions included: sub-speciality interest, geographical region, whether there is a pelvic binder in their hospital, availability of interventional radiology, and whether surgeons would perform a range of procedures to control @entity548 in the emergency setting. RESULTS: There were 141 responses to the survey, giving a 64% response rate. Only 18% reported that their unit had a formal rota for interventional radiology out of hours. 16% did not know. 96% of orthopaedic surgeons would perform external fixation, although only 49% would use a C-clamp. 90% of general surgeons would be able to pack the pelvis from within the abdominal compartment and 84% would be prepared to cross-clamp the aorta if the situation required. Despite being widely recommended in the literature as a method of @entity548 control, our survey revealed only 45% would perform extra(pre)-peritoneal packing of the pelvis (58% of general surgeons; 34% of orthopaedic surgeons) and only 12% had received formal training in this procedure. CONCLUSIONS: With appropriately targeted training it is likely that the care of @entity1 with @entity174 can be significantly improved.

title: XXXX control in @entity174 --a survey of surgical capabilities.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['pelvic fractures']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage']

answer: @entity548 :: (MESH:D006470,Disease) :: ['Haemorrhage']


abstract: BACKGROUND: In the emergency management of @entity1 with @entity174 , there is ongoing debate about the roles of angiography and open pelvic packing. It is agreed that some form of @entity548 control is required for @entity1 who are haemo-dynamically unstable despite resuscitation. We set out to determine whether on-call general and orthopaedic surgeons would feel able to perform emergency surgical procedures for these @entity1 and whether vascular radiology was available to them. METHODS: Surveys were sent to all 221 general and orthopaedic surgeons in Wales. Questions included: sub-speciality interest, geographical region, whether there is a pelvic binder in their hospital, availability of interventional radiology, and whether surgeons would perform a range of procedures to control @entity548 in the emergency setting. RESULTS: There were 141 responses to the survey, giving a 64% response rate. Only 18% reported that their unit had a formal rota for interventional radiology out of hours. 16% did not know. 96% of orthopaedic surgeons would perform external fixation, although only 49% would use a C-clamp. 90% of general surgeons would be able to pack the pelvis from within the abdominal compartment and 84% would be prepared to cross-clamp the aorta if the situation required. Despite being widely recommended in the literature as a method of @entity548 control, our survey revealed only 45% would perform extra(pre)-peritoneal packing of the pelvis (58% of general surgeons; 34% of orthopaedic surgeons) and only 12% had received formal training in this procedure. CONCLUSIONS: With appropriately targeted training it is likely that the care of @entity1 with @entity174 can be significantly improved.

title: @entity548 control in XXXX --a survey of surgical capabilities.

answer: @entity174 :: (MESH:D050723,Disease) :: ['pelvic fractures']


abstract: Despite its prevalence, clinical and prognostic impact, @entity4148 , is widely under-diagnosed. The need for training and expertise to perform the cardiovascular tests (usually the task of diabetologists) is one possible reason. The availability of computer-assisted systems has allowed a wider diffusion of testing, but has also highlighted the need for an adequate knowledge of physiopathological backgrounds for their correct application and interpretation. The recommendations presented here were developed by the @entity16 Study Group of the Italian Society of Diabetology and then endorsed by the Italian Association for the Study of Neurovegetative System, to promote the widespread adoption of good clinical practice in @entity65 autonomic testing by outlining main evidence-based aspects, i.e. which tests, how to perform them, adequate interpretation of the results and their diagnostic use, confounding conditions that can impact on tests reliability. Therefore, these recommendations include the essential aspects of the physiopathological substrate of the tests, the controversial points in their analysis, their diagnostic characteristics, as well as safety. Detailed information is given on the physiological (age, weight, body position, resting heart rate and blood pressure, respiratory pattern, exercise, meals, acute blood @entity413 changes) and pathophysiological confounding factors, with emphasis on the effects of drugs. Instructions on how to perform the tests and interpret their results are also considered together with indications of candidate @entity1 and periodicity of testing. A @entity1 instruction sheet on why and how to perform the tests is included. Finally, the specific requirements for computerized systems to perform and evaluate cardiovascular tests are provided.

title: Recommendations for the use of cardiovascular tests in diagnosing XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Neuropathy']

entities_list: @entity4148 :: ('MESH:D001342', 'Disease') :: ['diabetic autonomic neuropathy']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['diabetic cardiovascular']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity4148 :: (MESH:D001342,Disease) :: ['diabetic autonomic neuropathy']


abstract: BACKGROUND: @entity663 is a personality trait reflecting the tendency to experience negative affect. It is a major risk for psychopathology, especially @entity308 and @entity148 . Childhood maltreatment is another major risk factor for psychopathology and may influence personality. Maltreatment may interact with genotype to predict developmental outcomes. Variation in three polymorphisms of the @entity20583 gene has been found to moderate the association of childhood maltreatment with @entity308 , and we hypothesized that it would also be linked to @entity663 . METHODS: Variation in three @entity20583 SNPs ( @entity31244 , @entity31245 , @entity31243 ) was assessed in 339 maltreated and 275 demographically similar nonmaltreated @entity1 , who participated in a day camp research program. Maltreated @entity1 were further categorized based on the number of types of maltreatment they had experienced and the most severe form of maltreatment experienced. Genotype and maltreatment status were used to predict the Big Five personality traits, as assessed by camp counselors following a week of interaction with @entity1 . RESULTS:     @entity20583 genotype significantly moderated the association of maltreatment with @entity663 but none of the other traits. Having two copies of the TAT haplotype of @entity20583 was associated with higher levels of @entity663 among maltreated @entity1 relative to nonmaltreated @entity1 , with the exception of sexually abused @entity1 and @entity1 who had experienced 3 or 4 types of abuse. Effects sizes of these interactions ranged from   2=.01 (p=.02) to   2=.03 (p=.006). CONCLUSIONS: Variation in @entity20583 moderates the association of maltreatment with @entity663 . The effects of specific types of maltreatment on @entity663 are differentially moderated by @entity20583 genotype, as are the effects of experiencing more or fewer types of maltreatment.

title: Moderation of the association between childhood maltreatment and @entity663 by the XXXX gene.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety disorders']

entities_list: @entity663 :: ('MESH:C564323', 'Disease') :: ['neuroticism', 'Neuroticism']

answer: @entity20583 :: (1394,Gene) :: ['corticotropin-releasing hormone receptor 1']


abstract: BACKGROUND: @entity663 is a personality trait reflecting the tendency to experience negative affect. It is a major risk for psychopathology, especially @entity308 and @entity148 . Childhood maltreatment is another major risk factor for psychopathology and may influence personality. Maltreatment may interact with genotype to predict developmental outcomes. Variation in three polymorphisms of the @entity20583 gene has been found to moderate the association of childhood maltreatment with @entity308 , and we hypothesized that it would also be linked to @entity663 . METHODS: Variation in three @entity20583 SNPs ( @entity31244 , @entity31245 , @entity31243 ) was assessed in 339 maltreated and 275 demographically similar nonmaltreated @entity1 , who participated in a day camp research program. Maltreated @entity1 were further categorized based on the number of types of maltreatment they had experienced and the most severe form of maltreatment experienced. Genotype and maltreatment status were used to predict the Big Five personality traits, as assessed by camp counselors following a week of interaction with @entity1 . RESULTS:     @entity20583 genotype significantly moderated the association of maltreatment with @entity663 but none of the other traits. Having two copies of the TAT haplotype of @entity20583 was associated with higher levels of @entity663 among maltreated @entity1 relative to nonmaltreated @entity1 , with the exception of sexually abused @entity1 and @entity1 who had experienced 3 or 4 types of abuse. Effects sizes of these interactions ranged from   2=.01 (p=.02) to   2=.03 (p=.006). CONCLUSIONS: Variation in @entity20583 moderates the association of maltreatment with @entity663 . The effects of specific types of maltreatment on @entity663 are differentially moderated by @entity20583 genotype, as are the effects of experiencing more or fewer types of maltreatment.

title: Moderation of the association between childhood maltreatment and XXXX by the @entity20583 gene.

answer: @entity663 :: (MESH:C564323,Disease) :: ['neuroticism']


abstract: BACKGROUND: Admission with a multidisciplinary @entity130 team may be vital for the severely injured @entity1 , as this facilitates rapid diagnosis and treatment. On the other hand, @entity1 with minor injuries do not need the @entity130 team for adequate care. Correct triage is important for optimal resource utilization. The aim of the study was to evaluate our criteria for activating the @entity130 team, and identify suboptimal criteria that might be changed in the interest of precision. METHODS: The study is an observational, retrospective cohort-study. All @entity1 admitted with the @entity130 team (n = 382), all severely injured (Injury Severity Score (ISS) >15) (n = 161), and all undergoing an emergency procedure aimed at counteracting compromised airways, respiration or circulation at our hospital (n = 142) during 2006-2007 were included. Data were recorded from the admission records and the electronic @entity1 records. The @entity130 team activation protocol was evaluated against the occurrence of severe injury and the occurrence of emergency procedures. RESULTS: A total of 441 @entity1 were included. The overtriage was 71% and undertriage 32% when evaluating against ISS >15 as the standard of reference. When occurrence of emergency procedures was held as the standard of standard of reference, the over- and undertriage was 71% and 21%, respectively. Mechanism of injury-criteria for @entity130 team activation contributed the most to overtriage. The emergency procedures performed were mostly endotracheal intubation and external fixation of @entity174 . Less than 3% needed haemostatic laparotomy or thoracotomy. Approximately 2/3 of the overtriage represented isolated head or cervical spine injuries, and/or interhospital transfers. CONCLUSIONS: The over- and undertriage of our protocol are both too high. To decrease overtriage we suggest omissions and modifications of some of the criteria. To decrease undertriage, transferred @entity1 and @entity1 with @entity542 should be more thoroughly assessed against the @entity130 team activation criteria.

title: Evaluation of a university hospital XXXX team activation protocol.

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injuries']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: Several inflammatory markers have been investigated as prognostic parameters in a variety of @entity5 population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic @entity32 score (PIS) could further improve their prognostic values in surgical @entity1 with @entity14 ( @entity14 ). A total of 265 @entity1 who had undergone curative resection of @entity14 were reviewed retrospectively. Preoperative levels of inflammatory markers such as serum @entity1851 ( @entity1851 ), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and neutrophil/lymphocyte ratio (NLR) were assessed by uni- and multivariate survival analysis with disease-free (DFS) and @entity66 ( @entity66 ). PIS was constructed with a selective combination of inflammatory markers which were independently significant. On univariate analysis, @entity1851 , ESR, and NLR were significantly associated with DFS and @entity66 . On multivariate analysis, @entity1851 and NLR were independently significant prognostic variables for @entity66 and DFS respectively (P=0.013, P=0.021). When PIS was constructed with combination of @entity1851 and NLR, it was independently and significantly associated with both DFS and @entity66 (P=0.006, P=0.010). Furthermore, PIS was superior to @entity1851 for @entity66 (HR=15.679 vs. HR=5.183), and NLR for DFS in terms of prognosticating power (HR=4.894 vs. HR=2.687). When PIS is constructed with combination of @entity1851 and NLR, it is a potentially significant prognostic variable associated with poor survival regardless pathologic prognostic variables in @entity1 with @entity14 after curative resection.

title: @entity32 Score in Surgical @entity1 with XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['disease-specific survival', 'DSS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: Several inflammatory markers have been investigated as prognostic parameters in a variety of @entity5 population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic @entity32 score (PIS) could further improve their prognostic values in surgical @entity1 with @entity14 ( @entity14 ). A total of 265 @entity1 who had undergone curative resection of @entity14 were reviewed retrospectively. Preoperative levels of inflammatory markers such as serum @entity1851 ( @entity1851 ), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and neutrophil/lymphocyte ratio (NLR) were assessed by uni- and multivariate survival analysis with disease-free (DFS) and @entity66 ( @entity66 ). PIS was constructed with a selective combination of inflammatory markers which were independently significant. On univariate analysis, @entity1851 , ESR, and NLR were significantly associated with DFS and @entity66 . On multivariate analysis, @entity1851 and NLR were independently significant prognostic variables for @entity66 and DFS respectively (P=0.013, P=0.021). When PIS was constructed with combination of @entity1851 and NLR, it was independently and significantly associated with both DFS and @entity66 (P=0.006, P=0.010). Furthermore, PIS was superior to @entity1851 for @entity66 (HR=15.679 vs. HR=5.183), and NLR for DFS in terms of prognosticating power (HR=4.894 vs. HR=2.687). When PIS is constructed with combination of @entity1851 and NLR, it is a potentially significant prognostic variable associated with poor survival regardless pathologic prognostic variables in @entity1 with @entity14 after curative resection.

title: XXXX Score in Surgical @entity1 with @entity14 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity32 :: (MESH:D007249,Disease) :: ['Prognostic Inflammation']


abstract: Several inflammatory markers have been investigated as prognostic parameters in a variety of @entity5 population with mostly favorable results. This study aimed to verify the significance of common inflammatory markers as prognostic variables and assess whether a selective combination of them as prognostic @entity32 score (PIS) could further improve their prognostic values in surgical @entity1 with @entity14 ( @entity14 ). A total of 265 @entity1 who had undergone curative resection of @entity14 were reviewed retrospectively. Preoperative levels of inflammatory markers such as serum @entity1851 ( @entity1851 ), erythrocyte sedimentation rate (ESR), white blood cell count (WBC), and neutrophil/lymphocyte ratio (NLR) were assessed by uni- and multivariate survival analysis with disease-free (DFS) and @entity66 ( @entity66 ). PIS was constructed with a selective combination of inflammatory markers which were independently significant. On univariate analysis, @entity1851 , ESR, and NLR were significantly associated with DFS and @entity66 . On multivariate analysis, @entity1851 and NLR were independently significant prognostic variables for @entity66 and DFS respectively (P=0.013, P=0.021). When PIS was constructed with combination of @entity1851 and NLR, it was independently and significantly associated with both DFS and @entity66 (P=0.006, P=0.010). Furthermore, PIS was superior to @entity1851 for @entity66 (HR=15.679 vs. HR=5.183), and NLR for DFS in terms of prognosticating power (HR=4.894 vs. HR=2.687). When PIS is constructed with combination of @entity1851 and NLR, it is a potentially significant prognostic variable associated with poor survival regardless pathologic prognostic variables in @entity1 with @entity14 after curative resection.

title: @entity32 Score in Surgical XXXX with @entity14 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVES: To evaluate the prognostic effect of age in @entity1 with @entity1358 ( @entity1358 ) and investigate the incidence of Xp11 translocation @entity1358 in young @entity1 who developed recurrence. METHODS: From 1990 to 2007, 2403 Japanese @entity1 underwent nephrectomy for presumed @entity1358 at 9 institutions. Of those, 1143 @entity1 had localized @entity1358 (Stage pT1-2N0M0). Their clinical data were retrospectively reviewed. In the present study, 131 @entity1 (11%) were considered young ( <=45 years at diagnosis). In the young @entity1 with recurrence, the nephrectomy specimens were immunostained with @entity19409 to determine the incidence of Xp11 translocation @entity1358 . RESULTS: During the median follow-up of 47 months, 3 @entity5 deaths (2.2%) occurred among young @entity1 and 51 (5.0%) among older @entity1 . The 5-year @entity5 -specific survival (CSS) rate was significantly better for the younger @entity1 than for the older @entity1 (P = .049). Multivariate analysis showed that age was significantly associated with CSS, as were the pathologic T stage, @entity5 grade, and symptoms at diagnosis. The hazard ratio of young age was 0.31 (95% confidence interval 0.077-0.87). The recurrence-free survival curves revealed no difference between these 2 groups. Of the 74 @entity1 with recurrence, the CSS after recurrence was significantly better in the younger @entity1 than in the older @entity1 (P = .0010). Of the 8 young @entity1 with recurrence, 4 had Xp11 translocation @entity1358 , and 3 survived for >5 years after recurrence. CONCLUSIONS: Compared with the older @entity1 , the young @entity1 with @entity1358 had similar recurrence-free survival rates but better CSS rates. This might have been because significant numbers of the young @entity1 had Xp11 translocation @entity1358 .

title: Young age as favorable prognostic factor for @entity5 -specific survival in XXXX .

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['localized renal cell carcinoma', 'RCC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['localized renal cell carcinoma']


abstract: OBJECTIVES: To evaluate the prognostic effect of age in @entity1 with @entity1358 ( @entity1358 ) and investigate the incidence of Xp11 translocation @entity1358 in young @entity1 who developed recurrence. METHODS: From 1990 to 2007, 2403 Japanese @entity1 underwent nephrectomy for presumed @entity1358 at 9 institutions. Of those, 1143 @entity1 had localized @entity1358 (Stage pT1-2N0M0). Their clinical data were retrospectively reviewed. In the present study, 131 @entity1 (11%) were considered young ( <=45 years at diagnosis). In the young @entity1 with recurrence, the nephrectomy specimens were immunostained with @entity19409 to determine the incidence of Xp11 translocation @entity1358 . RESULTS: During the median follow-up of 47 months, 3 @entity5 deaths (2.2%) occurred among young @entity1 and 51 (5.0%) among older @entity1 . The 5-year @entity5 -specific survival (CSS) rate was significantly better for the younger @entity1 than for the older @entity1 (P = .049). Multivariate analysis showed that age was significantly associated with CSS, as were the pathologic T stage, @entity5 grade, and symptoms at diagnosis. The hazard ratio of young age was 0.31 (95% confidence interval 0.077-0.87). The recurrence-free survival curves revealed no difference between these 2 groups. Of the 74 @entity1 with recurrence, the CSS after recurrence was significantly better in the younger @entity1 than in the older @entity1 (P = .0010). Of the 8 young @entity1 with recurrence, 4 had Xp11 translocation @entity1358 , and 3 survived for >5 years after recurrence. CONCLUSIONS: Compared with the older @entity1 , the young @entity1 with @entity1358 had similar recurrence-free survival rates but better CSS rates. This might have been because significant numbers of the young @entity1 had Xp11 translocation @entity1358 .

title: Young age as favorable prognostic factor for XXXX -specific survival in @entity1358 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND: Several mechanisms may associate @entity2524 and related @entity32 with @entity73 . The authors studied the relationship between tooth @entity73 . METHODS: The REasons for Geographic And Racial Differences in @entity64 study is a national longitudinal study of more than 30,000 African American and white adults 45 years or older. Data for @entity2524 , cognitive function and potential confounding variables were available for 9,853 @entity1 at the time of analysis. The authors used incremental linear regression modeling to investigate the cross-sectional association between self-reported tooth @entity73 . RESULTS: In unadjusted analysis (mean learning followed by recall; a level of significance of .05), the loss of six to 16 teeth and the loss of more than 16 teeth were associated with poorer cognitive function compared with the loss of no teeth. Attenuated associations persisted after the authors adjusted for demographic and systemic risk factors. The full model, which was adjusted for socioeconomic status (SES), revealed no association between tooth @entity73 . CONCLUSION: @entity2524 may be associated with cognitive function; however, this association is mediated by age and SES. CLINICAL IMPLICATIONS: @entity2524 due to @entity2520 may be a marker for low SES, and the interplay of these factors with advanced age may confer risk of having poorer cognitive function. Further studies are needed to clarify these associations.

title: The association between self-reported tooth @entity73 in the REasons for Geographic And Racial Differences in XXXX study: an assessment of potential pathways.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['oral inflammation']

entities_list: @entity2520 :: ('MESH:D010510', 'Disease') :: ['periodontal disease']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment', 'loss and cognitive function']

entities_list: @entity2524 :: ('MESH:D016388', 'Disease') :: ['Tooth loss', 'tooth loss']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: BACKGROUND: Several mechanisms may associate @entity2524 and related @entity32 with @entity73 . The authors studied the relationship between tooth @entity73 . METHODS: The REasons for Geographic And Racial Differences in @entity64 study is a national longitudinal study of more than 30,000 African American and white adults 45 years or older. Data for @entity2524 , cognitive function and potential confounding variables were available for 9,853 @entity1 at the time of analysis. The authors used incremental linear regression modeling to investigate the cross-sectional association between self-reported tooth @entity73 . RESULTS: In unadjusted analysis (mean learning followed by recall; a level of significance of .05), the loss of six to 16 teeth and the loss of more than 16 teeth were associated with poorer cognitive function compared with the loss of no teeth. Attenuated associations persisted after the authors adjusted for demographic and systemic risk factors. The full model, which was adjusted for socioeconomic status (SES), revealed no association between tooth @entity73 . CONCLUSION: @entity2524 may be associated with cognitive function; however, this association is mediated by age and SES. CLINICAL IMPLICATIONS: @entity2524 due to @entity2520 may be a marker for low SES, and the interplay of these factors with advanced age may confer risk of having poorer cognitive function. Further studies are needed to clarify these associations.

title: The association between self-reported tooth XXXX in the REasons for Geographic And Racial Differences in @entity64 study: an assessment of potential pathways.

answer: @entity73 :: (MESH:D003072,Disease) :: ['loss and cognitive function']


abstract: OBJECTIVE: To investigate the larvicidal activity, inhibition effect on development, histopathological alteration and morphological aberration induced by the extracts derived from seaweeds Bryopsis pennata (B.  pennata), Sargassum binderi (S.  binderi) and Padina australis in @entity4224 (Ae. aegypti) larvae and to characterize the phytochemical components of the three seaweeds. METHODS: Larvicidal activity of the seaweeds towards the larvae of Ae. aegypti was determined according to WHO. The inhibition effect of seaweeds was assessed by determining the mortality, adult emergence rate, larval and pupa duration of the treated larvae. Histopathological effect on midgut epithelium of larvae and morphological aberration induced by the @entity1042 extracts were examined. Phytochemical analysis was done to determine the presence of alkaloids, @entity3857 , @entity230 and @entity6399 in the seaweeds. RESULTS: Chloroform partition of B.  pennata extract exhibited the strongest larvicidal activity (LC50  =  82.55   g/mL), followed by @entity1042 extract of B.  pennata (LC50  =  160.07   g/mL) and @entity3636 partition of S.  binderi extract (LC50  =  192.43   g/mL). The @entity1042 extract of S.  binderi exhibited the strongest effect on prolongation of larval period (1.5-fold longer as compared to control) and  resulted in strongest inhibition effect in adult emergence (98.67%). The histopathological study showed that larvae treated with seaweed extracts had cytopathological alteration of the midgut epithelium. The morphological observation revealed that the anal papillae and terminal spiracles of larvae were the common sites of aberrations. CONCLUSIONS: The study provided information on various effects of seaweed extracts on Ae. aegypti. Further investigation on identifying the active compounds and their mechanisms of action is recommended.

title: Larvicidal activity, inhibition effect on development, histopathological alteration and morphological aberration induced by seaweed extracts in XXXX (Diptera: Culicidae).

entities_list: @entity4224 :: ('7159', 'Species') :: ['Aedes aegypti']

entities_list: @entity6399 :: ('MESH:D013729', 'Chemical') :: ['terpenoids']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity3857 :: ('MESH:D012503', 'Chemical') :: ['saponins']

entities_list: @entity3636 :: ('MESH:D002725', 'Chemical') :: ['chloroform']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

answer: @entity4224 :: (7159,Species) :: ['Aedes aegypti']


abstract: OBJECTIVES: This study was designed to investigate the value of 3-D optical coherence tomography (3-D OCT) combined with fundus photochromy in the diagnosis of @entity697 (CSCR). SUBJECTS AND METHODS: 3-D OCT and fundus photochromy were performed on 30 @entity1 (36 eyes) with acute CSCR. @entity941 angiography (FA) was also performed to confirm the diagnosis and to obtain the @entity941 leakage sites. RESULTS: 22 eyes presented @entity1713 determined by 3-D OCT (28 leakage spots), 1 eye showed @entity989 ( @entity989 ) detachment (2 leakage spots), and 13 eyes showed both @entity989 (17 leakage spots). 3-D OCT showed significant changes in the @entity989 in 36 of 47 leakage spots (76.6%). Fundus photochromy showed white-gray changes in 22 of the 47 leakage spots (59.6%). 47 leakage spots were identified by FA in 36 eyes. The combination of 3-D OCT and fundus photochromy identified 42 of the 47 leakage spots (89.4%) spotted by FA. CONCLUSION: A combination of 3-D OCT and fundus photochromy offered a high identification rate of the leakage spots. The combination of the two noninvasive techniques may be used as an alternative diagnostic or evaluation tool for acute CSCR.

title: Value of three-dimensional optical coherence tomography and fundus photochromy in correlating the @entity941 leaking sites of XXXX .

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute central serous chorioretinopathy']

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['neurosensory retinal detachment']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['Fluorescein', 'fluorescein']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'neurosensory and RPE detachment', 'RPE']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute central serous chorioretinopathy']


abstract: OBJECTIVES: This study was designed to investigate the value of 3-D optical coherence tomography (3-D OCT) combined with fundus photochromy in the diagnosis of @entity697 (CSCR). SUBJECTS AND METHODS: 3-D OCT and fundus photochromy were performed on 30 @entity1 (36 eyes) with acute CSCR. @entity941 angiography (FA) was also performed to confirm the diagnosis and to obtain the @entity941 leakage sites. RESULTS: 22 eyes presented @entity1713 determined by 3-D OCT (28 leakage spots), 1 eye showed @entity989 ( @entity989 ) detachment (2 leakage spots), and 13 eyes showed both @entity989 (17 leakage spots). 3-D OCT showed significant changes in the @entity989 in 36 of 47 leakage spots (76.6%). Fundus photochromy showed white-gray changes in 22 of the 47 leakage spots (59.6%). 47 leakage spots were identified by FA in 36 eyes. The combination of 3-D OCT and fundus photochromy identified 42 of the 47 leakage spots (89.4%) spotted by FA. CONCLUSION: A combination of 3-D OCT and fundus photochromy offered a high identification rate of the leakage spots. The combination of the two noninvasive techniques may be used as an alternative diagnostic or evaluation tool for acute CSCR.

title: Value of three-dimensional optical coherence tomography and fundus photochromy in correlating the XXXX leaking sites of @entity697 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity941 :: (MESH:D019793,Chemical) :: ['fluorescein']


abstract: UNASSIGNED: The purpose of this investigation was to study the viral aetiology of @entity683 ( @entity683 ) and acute @entity1729 (ARTI) among @entity1 requiring intensive care unit admission. A cross-sectional retrospective study was carried out in Sicily over a 4-year period. A total of 233 respiratory samples of @entity1 with @entity683 /ARTI admitted to intensive care units were molecularly analyzed for the detection of a comprehensive panel of aetiologic agents of viral @entity1729 . About 45% of @entity1 was positive for at least one pathogen. Single aetiology occurred in 75.2% of infected @entity1 , while polymicrobial infection was found in 24.8% of positive subjects. Influenza was the most common aetiologic agent (55.7%), especially among adults. Most of @entity1 with multiple aetiology (76.9%) were adults and elderly. Mortality rates among @entity1 with negative or positive aetiology did not significantly differ (52.4% and 47.6%, respectively). Highly transmissible respiratory pathogens are frequently detected among @entity1 with @entity683 /ARTI admitted in intensive care units, showing the occurrence of concurrent @entity281 by different viruses. The knowledge of the circulation of several types of microorganisms is of crucial importance in terms of appropriateness of therapies, but also for the implication in prevention strategies and hospital epidemiology.

title: Burden and viral aetiology of @entity683 and XXXX in intensive care units.

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza-like illness', 'ILI']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['respiratory infections', 'respiratory tract infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

answer: @entity1729 :: (MESH:D012141,Disease) :: ['acute respiratory infection']


abstract: UNASSIGNED: The purpose of this investigation was to study the viral aetiology of @entity683 ( @entity683 ) and acute @entity1729 (ARTI) among @entity1 requiring intensive care unit admission. A cross-sectional retrospective study was carried out in Sicily over a 4-year period. A total of 233 respiratory samples of @entity1 with @entity683 /ARTI admitted to intensive care units were molecularly analyzed for the detection of a comprehensive panel of aetiologic agents of viral @entity1729 . About 45% of @entity1 was positive for at least one pathogen. Single aetiology occurred in 75.2% of infected @entity1 , while polymicrobial infection was found in 24.8% of positive subjects. Influenza was the most common aetiologic agent (55.7%), especially among adults. Most of @entity1 with multiple aetiology (76.9%) were adults and elderly. Mortality rates among @entity1 with negative or positive aetiology did not significantly differ (52.4% and 47.6%, respectively). Highly transmissible respiratory pathogens are frequently detected among @entity1 with @entity683 /ARTI admitted in intensive care units, showing the occurrence of concurrent @entity281 by different viruses. The knowledge of the circulation of several types of microorganisms is of crucial importance in terms of appropriateness of therapies, but also for the implication in prevention strategies and hospital epidemiology.

title: Burden and viral aetiology of XXXX and @entity1729 in intensive care units.

answer: @entity683 :: (MESH:D007251,Disease) :: ['influenza-like illness']


abstract: This study investigated the role of parental motivation (importance, confidence and readiness) for predicting dropout and outcome from family-based behavioral treatment for @entity28 . Parent and @entity1 demographics, adherence to treatment, and @entity353 parameters were also explored as potential predictors. Eighty-four @entity28 @entity1 (BMI-standard deviation scores ( @entity214 ) >2.14) and a participating parent with each @entity1 started treatment consisting of 12 weeks of group and individual treatment sessions (24 sessions total) delivered over a period of 18 weeks. Sixty-one families (73%) completed treatment and attended follow-up at 1 year after treatment. @entity1 session attendance and completion of self-monitoring records served as measures of adherence. In regression analyses, parent reports (pretreatment) of confidence for doing well in treatment was the strongest predictor of treatment completion (P = 0.003) as well as early treatment response ( @entity353 at week 5) (P = 0.003). This variable remained a significant predictor of @entity1 @entity353 at post-treatment (P = 0.014), but was not associated with @entity1 outcome at 1-year follow-up (P > 0.05). The only significant predictor of @entity1 @entity353 at that point was @entity1 baseline weight (P = 0.001). However, pretreatment parent ratings of importance of and readiness for treatment did not predict dropout or @entity353 at any point. The results underscore the importance of addressing parental motivation, specifically parental confidence for changing lifestyle related behaviors, early in the treatment process. Doing so may reduce treatment dropout and enhance treatment outcome.

title: The role of parental motivation in family-based treatment for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'children', 'child']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['childhood obesity', 'obese']

answer: @entity28 :: (MESH:D009765,Disease) :: ['childhood obesity']


abstract: INTRODUCTION: During 2008-2012, a total of 466 ticks Ixodes ricinus removed from @entity1 were collected and tested for the presence of @entity2069 sensu lato (Bbsl). Ticks were collected in all districts of the South Moravian region of the Czech Republic (CZ). OBJECTIVE: The aim of this study was to determine the infestation of Bbsl in ticks Ixodes ricinus and the identification of genospecies of Bbsl group by DNA sequencing. MATERIAL AND METHODS: DNA isolation from homogenates was performed by UltraClean BloodSpin DNA kit (MoBio) and by automated instrument Prepito (Perkin-Elmer). Detection of spirochetes was carried out by RealTime PCR kit EliGene @entity12732 (Elisabeth Pharmacon). Finally, all the positive samples were sequenced on an ABI 3130 Genetic Analyzer (Life Technologies) and identified in the BLAST (NCBI) database. RESULTS: A total positivity of the samples was 26%. For the first time in the Czech Republic, 5 of the isolated strains were genotyped as @entity69881 (7.1%). Other representatives of Bbsl were also observed: @entity21786 (70.0%), @entity25974 (10.0%), @entity18276 (8.6%), and @entity2069 s. s. (4.3%). CONCLUSION: A general view of the spreading of Bbsl in the South Moravian region was demonstrated. The most interesting result of the study is the finding of @entity69881 for the first time in this region.

title: Identification of XXXX genospecies isolated from Ixodes ricinus ticks in the South Moravian region of the Czech Republic.

entities_list: @entity2069 :: ('139', 'Species') :: ['B. burgdorferi', 'Borrelia burgdorferi']

entities_list: @entity12732 :: ('MESH:D001899', 'Disease') :: ['Borrelia LC']

entities_list: @entity69881 :: ('88916', 'Species') :: ['Borrelia spielmanii', 'B. spielmanii']

answer: @entity2069 :: (139,Species) :: ['Borrelia burgdorferi']


abstract: @entity43 makes up 25-30% of all cases of @entity5 of the female genital tract. It has the highest mortality rate of any condition in oncological gynaecology. Early diagnosis is associated with a favourable 5-year survival prognosis. Many solid @entity5 have been detected with concomitant @entity1148 . The @entity5 cell-induced @entity1423 is a result of a direct integration of @entity5 cells with blood platelets. The aim of the present paper is an evaluation of platelet count as a prognostic parameter for @entity43 . Between 2000 - 2005, 349 @entity1 with @entity43 (aged 12 - 88-years-old) underwent primary surgical treatment at a clinic. Ninety-seven @entity1 with @entity43 underwent chemotherapy in the Oncology Centre. The control group comprised 252 @entity1 diagnosed with a histopathological lesion of mild intensity, whereas the @entity5 group constituted 97 @entity1 with a histopathologically-diagnosed malignant @entity5 . Thrombocytopaenia was assumed with a platelet count below @entity54914 and thrombocythaemia at 350G/L and higher. @entity1148 often coincides with @entity843 and the cytoreduction decreases platelet count. There is a positive correlation between platelet count and @entity5 grading. @entity1148 was more frequently found in high grade @entity5 . There is also a positive correlation between platelet count and @entity5 stage according the International Federation of Gynaecology and Obstetrics (FIGO). @entity1148 was more frequently found in stage III and IV @entity5 . @entity1 with co-occurring @entity1148 were found to have shorter survival periods and shorter time free from disease. This seems to give grounds for measuring platelet count before the primary surgical intervention, and suggests that the platelet count should be included in the panel of prognostic factors for @entity1 with @entity43 .

title: The prognostic significance of XXXX in @entity43 .

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian tumour', 'ovarian carcinomas', 'ovarian cancer', 'ovarian tumours', 'Ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['Thrombocytosis', 'thrombocytosis']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumours', 'neoplasm', 'tumour']

answer: @entity1148 :: (MESH:D013922,Disease) :: ['thrombocytosis']


abstract: @entity43 makes up 25-30% of all cases of @entity5 of the female genital tract. It has the highest mortality rate of any condition in oncological gynaecology. Early diagnosis is associated with a favourable 5-year survival prognosis. Many solid @entity5 have been detected with concomitant @entity1148 . The @entity5 cell-induced @entity1423 is a result of a direct integration of @entity5 cells with blood platelets. The aim of the present paper is an evaluation of platelet count as a prognostic parameter for @entity43 . Between 2000 - 2005, 349 @entity1 with @entity43 (aged 12 - 88-years-old) underwent primary surgical treatment at a clinic. Ninety-seven @entity1 with @entity43 underwent chemotherapy in the Oncology Centre. The control group comprised 252 @entity1 diagnosed with a histopathological lesion of mild intensity, whereas the @entity5 group constituted 97 @entity1 with a histopathologically-diagnosed malignant @entity5 . Thrombocytopaenia was assumed with a platelet count below @entity54914 and thrombocythaemia at 350G/L and higher. @entity1148 often coincides with @entity843 and the cytoreduction decreases platelet count. There is a positive correlation between platelet count and @entity5 grading. @entity1148 was more frequently found in high grade @entity5 . There is also a positive correlation between platelet count and @entity5 stage according the International Federation of Gynaecology and Obstetrics (FIGO). @entity1148 was more frequently found in stage III and IV @entity5 . @entity1 with co-occurring @entity1148 were found to have shorter survival periods and shorter time free from disease. This seems to give grounds for measuring platelet count before the primary surgical intervention, and suggests that the platelet count should be included in the panel of prognostic factors for @entity1 with @entity43 .

title: The prognostic significance of @entity1148 in XXXX .

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: Fumonisins are mycotoxins produced by @entity18327 (= @entity18327 ) and other Fusarium species. They are found in @entity4336 and @entity4336 -based foods. Cooking decreases @entity20695 concentrations in food products under some conditions; however, little is known about how cooking effects biological activity. Baked cornbread, pan-fried corncakes, and deep-fried fritters were made from cornmeal that was spiked with 5% w/w @entity18327 culture material (CM). The cooked materials and the uncooked CM-spiked cornmeal were fed to male @entity35 (n = 5/group) for 2 weeks at high (20% w/w spiked cornmeal equivalents) or low (2% w/w spiked cornmeal equivalents) doses. A control group was fed a diet containing 20% w/w unspiked cornmeal. Toxic response to the uncooked CM-spiked cornmeal and the cooked products included decreased body @entity1017 (high-dose only), decreased kidney weight, and microscopic kidney and liver lesions of the type caused by fumonisins. @entity20695 concentration, as determined by HPLC analysis, in the 20% w/w pan-fried corncake diet [92.2 ppm of @entity18639 (FB(1))] was slightly, but not statistically significantly, lower than those of the 20% w/w baked cornbread (132.2 ppm of @entity18640 ), deep-fried fritter (120.2 ppm of @entity18640 ) and CM-spiked cornmeal (130.5 of ppm FB(1)) diets. Therefore, baking and frying had no significant effect on the biological activity or concentration of @entity18641 in these @entity4336 -based products, and the results provided no evidence for the formation of novel toxins or "hidden" fumonisins during cooking.

title: Effect of baking and frying on the in vivo toxicity to XXXX of cornmeal containing fumonisins.

entities_list: @entity18641 :: ('MESH:D037341', 'Chemical') :: ['fumonisins']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity18327 :: ('117187', 'Species') :: ['F. moniliforme', 'F. verticillioides', 'Fusarium verticillioides']

entities_list: @entity20695 :: ('CHEBI:38224', 'Chemical') :: ['Fumonisin', 'fumonisin']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: @entity981 ( @entity981 ) is a malignancy that occurs in white blood cells. The overall cure rate in @entity1 is 85%, whereas it is only 40% in adults. Kefir is an important probiotic that contains many bioactive ingredients, which give it unique health benefits. It has been shown to control several cellular types of @entity5 . PURPOSE: The present study investigates the effect of a cell-free fraction of kefir on CEM and Jurkat cells, which are @entity1 T-lymphotropic virus type I (HTLV- @entity2662 )-negative malignant T-lymphocytes. METHODS: Cells were incubated with different kefir concentrations. The @entity137 of the compound was evaluated by determining the percentage viability of cells. The effect of all the noncytotoxic concentrations of kefir on the proliferation of CEM and Jurkat cells was then assessed. The levels of @entity310 ( @entity7790 ), @entity2533 ( @entity2533 ), @entity1476 ( @entity1476 ), and @entity1495 mRNA upon kefir treatment were then analyzed using reverse transcriptase polymerase chain reaction (RT-PCR). Finally, the growth inhibitory effects of kefir on cell-cycle progression/apoptosis were assessed by Cell Death Detection (ELISA) and flow cytometry. RESULTS: The maximum @entity137 recorded after 48-hours treatment with 80  g/ L kefir was only 42% and 39% in CEM and Jurkat cells, respectively. The percent reduction in proliferation was very significant, and was dose-, and time-dependent. In both cell lines, kefir exhibited its antiproliferative effect by downregulating @entity7790 and upregulating @entity2533 mRNA expression. Upon kefir treatment, a marked increase in cell-cycle distribution was noted in the preG(1) phase of CEM and Jurkat cells, indicating the proapoptotic effect of kefir, which was further confirmed by Cell Death Detection ELISA. However, kefir did not affect the mRNA expression of metalloproteinases needed for the invasion of leukemic cell lines. CONCLUSION: In conclusion, kefir is effective in inhibiting proliferation and inducing apoptosis of @entity2662 -negative malignant T-lymphocytes. Therefore, further in vivo investigation is highly recommended.

title: Kefir induces cell-cycle arrest and apoptosis in XXXX -negative malignant T-lymphocytes.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['Adult lymphoblastic leukemia', 'ALL']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity1476 :: ('4313', 'Gene') :: ['matrix metalloproteinase-2', 'MMP-2']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity310 :: ('7124', 'Gene') :: ['transforming growth factor-alpha']

entities_list: @entity2533 :: ('7040', 'Gene') :: ['transforming growth factor- beta1', 'TGF-b1']

answer: @entity2662 :: (11908,Species) :: ['HTLV-1']


abstract: We performed a MEDLINE and EMBASE search to identify all studies published in the last decade in the English language literature on the use of progestogens for the treatment of @entity46 . Our aim was to clarify the biological rationale for treatment and define the drugs that can be used with their doses, routes of administration, efficacy and tolerability. Progestogens may prevent implantation and growth of regurgitated endometrium inhibiting expression of matrix metalloproteinases and angiogenesis, and they have several anti-inflammatory in-vitro and in-vivo effects that may reduce the inflammatory state generated by the metabolic activity of the ectopic endometrium, and the consequent immune response. Oral contraceptives increase the abnormally low apoptotic activity of the endometrium of @entity1 with @entity46 . Moreover, anovulation, decidualization, @entity4999 and the establishment of a steady @entity172 -progestogen milieu contribute to disease quiescence. Progestogens are effective in the control of @entity158 symptoms in approximately three out of four @entity1 with @entity46 . Their effect does not seem to be inferior to that of other drugs used for the disease. Different compounds can be administered by the oral, intramuscular, subcutaneous, intravaginal or intrauterine route, each with specific advantages or disadvantages. Medical treatment plays a role in the therapeutic strategy when administered over a prolonged period of time. Given their good tolerability, minor metabolic effects and low cost, progestogens must therefore be considered drugs of choice and are currently the only safe and economic alternative to surgery. However, their contraceptive effectiveness limits their use to @entity1 who do not wish to have @entity1 in the short term.

title: Progestogens for XXXX : forward to the past.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity4999 :: ('MESH:C537962', 'Disease') :: ['amenorrhoea']

answer: @entity46 :: (MESH:D004715,Disease) :: ['endometriosis']


abstract: OBJECTIVE: To evaluate the effects of a high-protein diet versus dietary supplementation with @entity5819 ( @entity8777 ) on @entity5706 crystal formation in the urine of clinically normal @entity468 by measuring the urine concentration of @entity5836 ( @entity5828 )-insoluble sediment, urine pH, @entity5706 activity product (SAP), number of @entity5706 crystals in urine, and urine volume. ANIMALS: 23 healthy adult @entity468 . PROCEDURE: Urine was fractionated by centrifugation with subsequent extraction of the sediment with 1 N @entity5828 (study 1). Diets containing either 29% crude protein or 55% crude protein were fed to @entity468 in a crossover trial of 3 weeks/period (study 2). Diets supplemented with either @entity2827 ( @entity1219 ) or @entity8777 were fed, by use of a 3 x 3 Latin-square design with 3 wk/period (study 3). In studies 2 and 3, urine samples were collected for the last 7 days of each period. RESULTS: The @entity5828 -insoluble sediment contained Tamm-Horsfall glycoprotein (THP; study 1). The high-protein diet (study 2) and dietary supplementation with @entity8777 (study 3) resulted in a decrease in urine pH, SAP, and the number of @entity5706 crystals in urine. However, the high-protein diet decreased urine concentrations of @entity5828 -insoluble sediment containing THP (study 2), in contrast to the @entity8777 supplementation that increased urine volume without a significant effect on the urine concentration of the @entity5828 -insoluble sediment (study 3). CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that compared with dietary supplementation with @entity8777 , the high-protein diet is preferable as a urine acidifier for the prevention of @entity5706 crystal formation in clinically normal @entity468 .

title: Effects of a high-protein diet versus dietary supplementation with XXXX on @entity5706 crystal formation in urine of clinically normal @entity468 .

entities_list: @entity5836 :: ('MESH:D006851', 'Chemical') :: ['hydrochloric acid']

entities_list: @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride']

entities_list: @entity5706 :: ('MESH:C009330', 'Chemical') :: ['struvite']

entities_list: @entity5819 :: ('MESH:D000643', 'Chemical') :: ['ammonium chloride']

answer: @entity5819 :: (MESH:D000643,Chemical) :: ['ammonium chloride']


abstract: OBJECTIVE: To evaluate the effects of a high-protein diet versus dietary supplementation with @entity5819 ( @entity8777 ) on @entity5706 crystal formation in the urine of clinically normal @entity468 by measuring the urine concentration of @entity5836 ( @entity5828 )-insoluble sediment, urine pH, @entity5706 activity product (SAP), number of @entity5706 crystals in urine, and urine volume. ANIMALS: 23 healthy adult @entity468 . PROCEDURE: Urine was fractionated by centrifugation with subsequent extraction of the sediment with 1 N @entity5828 (study 1). Diets containing either 29% crude protein or 55% crude protein were fed to @entity468 in a crossover trial of 3 weeks/period (study 2). Diets supplemented with either @entity2827 ( @entity1219 ) or @entity8777 were fed, by use of a 3 x 3 Latin-square design with 3 wk/period (study 3). In studies 2 and 3, urine samples were collected for the last 7 days of each period. RESULTS: The @entity5828 -insoluble sediment contained Tamm-Horsfall glycoprotein (THP; study 1). The high-protein diet (study 2) and dietary supplementation with @entity8777 (study 3) resulted in a decrease in urine pH, SAP, and the number of @entity5706 crystals in urine. However, the high-protein diet decreased urine concentrations of @entity5828 -insoluble sediment containing THP (study 2), in contrast to the @entity8777 supplementation that increased urine volume without a significant effect on the urine concentration of the @entity5828 -insoluble sediment (study 3). CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that compared with dietary supplementation with @entity8777 , the high-protein diet is preferable as a urine acidifier for the prevention of @entity5706 crystal formation in clinically normal @entity468 .

title: Effects of a high-protein diet versus dietary supplementation with @entity5819 on XXXX crystal formation in urine of clinically normal @entity468 .

answer: @entity5706 :: (MESH:C009330,Chemical) :: ['struvite']


abstract: OBJECTIVE: To evaluate the effects of a high-protein diet versus dietary supplementation with @entity5819 ( @entity8777 ) on @entity5706 crystal formation in the urine of clinically normal @entity468 by measuring the urine concentration of @entity5836 ( @entity5828 )-insoluble sediment, urine pH, @entity5706 activity product (SAP), number of @entity5706 crystals in urine, and urine volume. ANIMALS: 23 healthy adult @entity468 . PROCEDURE: Urine was fractionated by centrifugation with subsequent extraction of the sediment with 1 N @entity5828 (study 1). Diets containing either 29% crude protein or 55% crude protein were fed to @entity468 in a crossover trial of 3 weeks/period (study 2). Diets supplemented with either @entity2827 ( @entity1219 ) or @entity8777 were fed, by use of a 3 x 3 Latin-square design with 3 wk/period (study 3). In studies 2 and 3, urine samples were collected for the last 7 days of each period. RESULTS: The @entity5828 -insoluble sediment contained Tamm-Horsfall glycoprotein (THP; study 1). The high-protein diet (study 2) and dietary supplementation with @entity8777 (study 3) resulted in a decrease in urine pH, SAP, and the number of @entity5706 crystals in urine. However, the high-protein diet decreased urine concentrations of @entity5828 -insoluble sediment containing THP (study 2), in contrast to the @entity8777 supplementation that increased urine volume without a significant effect on the urine concentration of the @entity5828 -insoluble sediment (study 3). CONCLUSIONS AND CLINICAL RELEVANCE: Our results indicate that compared with dietary supplementation with @entity8777 , the high-protein diet is preferable as a urine acidifier for the prevention of @entity5706 crystal formation in clinically normal @entity468 .

title: Effects of a high-protein diet versus dietary supplementation with @entity5819 on @entity5706 crystal formation in urine of clinically normal XXXX .

answer: @entity468 :: (9685,Species) :: ['cats']


abstract: Fructans are fermentable carbohydrates and include short-chain fructooligosaccharides (scFOS), inulin, and hydrolyzed inulin ( @entity11276 , OF). Two studies with @entity235 were designed to examine the effects of low concentrations of fructans on nutrient digestibilities, fecal microbial populations, and endproducts of protein fermentation, and fecal characteristics. In Exp. 1, 11 adult male beagles were fed @entity4336 -based, kibbled diets supplemented with or without OF to provide 1.9 +/- 0.6 g/d. Dietary inclusion of OF decreased (P < 0.05) nutrient digestibilities, but did not affect fecal characteristics. Increasing OF concentration tended (P < 0.06) to linearly decrease fecal @entity3265 concentrations, but not those of @entity27949 ( @entity27949 ), @entity4478 , @entity104 , or @entity11572 . Fecal concentrations of total @entity22780 (SCFA) and butyrate tended to be higher in OF-supplemented @entity235 (P < 0.10), as was the ratio of bifidobacteria to total anaerobes (P = 0.15). In Exp. 2, ileally cannulated adult female hounds were fed a meat-based kibbled diet and were assigned to four scFOS treatments (0, 1, 2, or 3 g/d) in a 4 x 4 Latin square design. Ileal nutrient digestibilities tended to increase (P < 0.15) with increasing concentrations of scFOS. On a DMI basis, fecal output tended to decrease linearly (P < 0.10) in response to increasing scFOS supplementation, whereas fecal score tended to exhibit a quadratic response (P = 0.12). In general, fecal concentrations of SCFA, @entity27949 , @entity3265 , @entity11572 , and @entity27329 were not altered by supplemental scFOS. Supplementation of scFOS increased fecal concentrations of total aerobes (P < 0.05) and decreased concentrations of @entity3168 (P < 0.05). From these data, it seems that low levels of supplemental fructans have divergent effects on nutrient digestibility and fermentative endproducts, but do not adversely affect nutrient digestibility or fecal characteristics and may improve colonic microbial ecology in @entity235 .

title: Nutrient digestibilities, microbial populations, and protein catabolites as affected by fructan supplementation of XXXX diets.

entities_list: @entity27949 :: ('CHEBI:35819', 'Chemical') :: ['BCFA', 'branched-chain fatty acids']

entities_list: @entity11276 :: ('MESH:C120489', 'Chemical') :: ['oligofructose']

entities_list: @entity3168 :: ('1502', 'Species') :: ['Clostridium perfringens']

entities_list: @entity22780 :: ('MESH:D005232', 'Chemical') :: ['short-chain fatty acids']

answer: @entity235 :: (9615,Species) :: ['dog']


abstract: The aim of this study was to examine maximal voluntary knee-extensor contraction force (MVC force), sarcoplasmic reticulum (SR) function and muscle glycogen levels in the days after a high-level soccer game when players ingested an optimised diet. Seven high-level male soccer players had a vastus lateralis muscle biopsy and a blood sample collected in a control situation and at 0, 24, 48 and 72 h after a competitive soccer game. MVC force, SR function, muscle glycogen, muscle soreness and plasma myoglobin were measured. MVC force sustained over 1 s was 11 and 10% lower (P < 0.05) after 0 and 24 h, respectively, compared with control. The rate of SR @entity141 uptake at 800 nM [ @entity141 ](free) was lower (P < 0.05) after 0 h (2.5  mol @entity141 g prot(-1) min(-1)) than for all other time points (24 h: 5.1  mol @entity141 g prot(-1) min(-1)). However, SR @entity141 release rate was not affected. Plasma myoglobin was sixfold higher (P < 0.05) immediately after the game, but normalised 24 h after the game. Quadriceps muscle soreness (0-10 VAS-scale) was higher (P < 0.05) after 0 h (3.6), 24 h (1.8), 48 h (1.1) and 72 h (1.4) compared with control (0.1). Muscle glycogen was 57 and 27% lower (P < 0.001) 0 and 24 h after the game compared with control (193 and 328 vs. 449 mmol kg d w(-1)). In conclusion, maximal @entity2472 force and SR @entity141 uptake were impaired and muscle soreness was elevated after a high-level soccer game, with faster recovery of SR function in comparison with MVC force, soreness and muscle glycogen.

title: XXXX force, SR function and glycogen resynthesis during the first 72 h after a high-level competitive soccer game.

entities_list: @entity2472 :: ('MESH:C536214', 'Disease') :: ['voluntary contraction']

answer: @entity2472 :: (MESH:C536214,Disease) :: ['Maximal voluntary contraction']


abstract: BACKGROUND/AIMS: Several studies have found that the frequency of @entity1127 increases significantly from the age of 50 years. The goal of this study was to determine the differences in the clinical characteristics of @entity1127 between @entity1 aged 50 years and older, and younger @entity1 . METHODS: The colonoscopy database of 3,304 @entity1 at the Yeungnam University Medical Center between January 2009 and December 2009 was reviewed retrospectively. In total, 679 @entity1 were divided into the younger group (n=170) and the older group (aged >= 50 years) (n=509). A matched case-control study was performed using propensity scores and 117 @entity1 selected from each group. RESULTS: Compared to the younger group, the older group had a significantly higher proportion of female @entity1 , and @entity1 with @entity101 , a smoking history, and a history of taking medications. After performing the matched case-control study, 234 @entity1 and 679 @entity1586 were included in the analysis. Compared to the younger @entity1 , the older @entity1 had a significantly higher proportion of @entity75 (57.3% vs 25.6%, p<0.001), left- and right-side distribution (35.9% vs 12.0%, p<0.001), and larger @entity1127 (mean 9.1 mm vs 6.3 mm, p<0.001). A left-sided distribution was less common in the older group than in the younger group (35.0% vs 51.3%, p=0.025). CONCLUSIONS: The methods used to screen for @entity14 in older @entity1 should include colonoscopy due to the shift to the right side as a common location for @entity1127 in that age group.

title: A Matched Case-Control Study Using the Propensity Score on Differences in the Characteristics of @entity1127 between Younger and Older Koreans: Proximal Shift in the Distribution of XXXX among Older Koreans.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1127 :: ('MESH:D011127', 'Disease') :: ['colorectal polyps', 'polyps']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['multiple lesions']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity1586 :: ('MESH:D003111', 'Disease') :: ['colon polyps']

answer: @entity1127 :: (MESH:D011127,Disease) :: ['Colorectal Polyps']


abstract: BACKGROUND/AIMS: Several studies have found that the frequency of @entity1127 increases significantly from the age of 50 years. The goal of this study was to determine the differences in the clinical characteristics of @entity1127 between @entity1 aged 50 years and older, and younger @entity1 . METHODS: The colonoscopy database of 3,304 @entity1 at the Yeungnam University Medical Center between January 2009 and December 2009 was reviewed retrospectively. In total, 679 @entity1 were divided into the younger group (n=170) and the older group (aged >= 50 years) (n=509). A matched case-control study was performed using propensity scores and 117 @entity1 selected from each group. RESULTS: Compared to the younger group, the older group had a significantly higher proportion of female @entity1 , and @entity1 with @entity101 , a smoking history, and a history of taking medications. After performing the matched case-control study, 234 @entity1 and 679 @entity1586 were included in the analysis. Compared to the younger @entity1 , the older @entity1 had a significantly higher proportion of @entity75 (57.3% vs 25.6%, p<0.001), left- and right-side distribution (35.9% vs 12.0%, p<0.001), and larger @entity1127 (mean 9.1 mm vs 6.3 mm, p<0.001). A left-sided distribution was less common in the older group than in the younger group (35.0% vs 51.3%, p=0.025). CONCLUSIONS: The methods used to screen for @entity14 in older @entity1 should include colonoscopy due to the shift to the right side as a common location for @entity1127 in that age group.

title: A Matched Case-Control Study Using the Propensity Score on Differences in the Characteristics of XXXX between Younger and Older Koreans: Proximal Shift in the Distribution of @entity1127 among Older Koreans.

answer: @entity1127 :: (MESH:D011127,Disease) :: ['Colorectal Polyps']


abstract: The scaphocapitate @entity174 is a rare entity of a perilunate @entity174 . The diagnosis is frequently missed at initial presentation to a physician. Usually, a CT scan is required to reveal the extent of the lesion. Operative treatment consists of open reduction and internal fixation with screws (e.g. headless compression screw) or Kirschner wires. We report on a case of a 19-year-old @entity1 who presented to our hospital 2 months after he fell on his left wrist. He complained about persistent @entity158 and a decreased range of motion after conservative treatment in a short arm cast. The diagnosis was finally made by a CT scan and the @entity1 was treated operatively using headless compression screws in both the capitate and the scaphoid. After 12 weeks, @entity174 were completely healed radiographically and the @entity1 returned to work. At follow-up 16 months after @entity130 , the @entity1 had no further complaints. Range of motion increased and no avascular @entity39 could be observed.

title: Successful delayed surgical treatment of a scaphocapitate XXXX .

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture-dislocation', 'fracture syndrome']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture']


abstract: The seeds of Tectona grandis Linn. are traditionally acclaimed as hair tonic in the Indian system of medicine. Studies were therefore undertaken in order to evaluate petroleum ether extract of T. grandis seeds for its effect on hair growth in albino @entity19 . The 5% and 10% extracts incorporated into simple ointment base were applied topically on shaved denuded skin of albino @entity19 . The time required for initiation of hair growth as well as completion of hair growth cycle was recorded. @entity5491 2% solution was applied topically and served as positive control. The result of treatment with @entity5491 2% is 49% hair in anagenic phase. Hair growth initiation time was significantly reduced to half on treatment with the extracts compared to control animals. The treatment was successful in bringing a greater number of hair follicles (64% and 51%) in anagenic phase than standard @entity5491 (49%). The results of treatment with 5% and 10% petroleum ether extracts were comparable to the positive control @entity5491 .

title: Effect of Tectona grandis Linn. seeds on hair growth activity of albino XXXX .

entities_list: @entity5491 :: ('MESH:D008914', 'Chemical') :: ['minoxidil', 'Minoxidil']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: Lymph node ratio (LNR) has been reported to represent a powerful independent prognostic value in some @entity5 . The significance of LNR in @entity14 is still under debate. METHODS: A total of 505 @entity1 with @entity14 were reviewed. Using running log-rank statistics, we calculated the best cutoff values for LNRs and proposed a novel rN category: rN1, 0%  <  LNR   <=  35%; rN2, 35%  <  LNR   <=  69%; and @entity49581 , LNR  >  69%. A Spearman's correlation coefficient test was used to assess the correlation between the number of retrieved nodes and the number of metastatic nodes, as well as the number of retrieved nodes and the LNRs. Univariate and two-step multivariate analyses were performed, respectively, to identify the significant prognostic clinicopathologic factors. RESULTS: The 5-year overall survival rate decreased significantly with increasing LNRs: rN(1)  =  61% survival rate, rN(2)  =  30.3% survival rate, and rN(3)  =  11.2% survival rate (P  <  0.001). Univariate and two-step multivariate analyses identified the rN category as a significant prognostic factor no matter whether the minimum number of LNs retrieved was met. There was a significant prognostic difference among different rN categories for any pN category, but no apparent prognostic difference was seen between different pN categories in any rN category. Moreover, marked heterogeneity could be seen within III(a-c) substages when survival was compared among rN(1-3) categories but not between pN(1-2) categories. CONCLUSIONS: rN categories have more potential for predicting @entity1 outcomes and are superior to the UICC/AJCC pN categories. We recommend rN categories for prognostic assessment and rN categories should be reported routinely in histopathological reports.

title: Can lymph node ratio take the place of pN categories in the UICC/AJCC TNM classification system for XXXX ?

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['stage III colorectal cancer', 'colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: OBJECTIVE: To explore the efficacy difference in @entity1017 between auricular point sticking and the combined therapy of auricular point sticking and body acupuncture, as well as the efficacy difference among various body constitutions. METHODS: One hundred cases of @entity1017 were randomized into two groups, auricular point sticking group (group A) and the combined therapy of auricular point sticking and body acupuncture group (group B), 50 cases in each one. In group A, semen vaccariae was fixed with plaster on the spleen, stomach, endocrine, small intestine, buttocks, tibia, forearm, etc. in the ear. Each point was pressed 3 times daily, for 5 mm each time. The ear-points on two sides were alternated every two days. In group B, the auricular point sticking and body acupuncture were applied. The ear points and manipulation were same as the previous. Body points were Zhongwan (CV 12), (Juanyuan (CV 4), Tiansho (ST 25), Zusanli (ST 36), Sanyinjiao ( @entity8949 ), etc. Acupuncture was applied with filiform needle, once every two days. The changes in body weight and body mass index (BMI) were observed after 20 treatments. RESULTS: (1) The total effective rate was 94.0% (47/50) in group A and was 98.0% (49/50) in group B, without statistical significant difference (P > 0.05). The comparison of mean body weight and mean BMI after intervention did not show statistical significance between two groups (both P > 0.05), indicating that the simple auricular point sticking could achieve the same effect as the combined therapy. (2) There was no statistical significant difference in the total effective rate between the thin @entity1 with spleen and @entity1819 constitution and those with normal constitution among 100 cases (P > 0.05). But, the remarkable effective rates were different significantly in statistics (P < 0.05). For the thin @entity1 with spleen and @entity1819 constitution, after treatment, the body weight increased in big amplitude, but those with normal constitution increased in small amplitude or had no change. CONCLUSION: The efficacy of the simple auricular point sticking on @entity1017 is same as the combined therapy of auricular point sticking and body acupuncture, and is much better for the cases with spleen and @entity1819 constitution.

title: [Auricular point sticking and the combined therapy of auricular point sticking and body acupuncture for XXXX in 100 cases].

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['stomach deficiency']

answer: @entity1017 :: (MESH:D015430,Disease) :: ['weight gain']


abstract: The morphology of the large intrapulmonary arteries (PAs) in @entity120 ( @entity120 ) has received limited attention. Dilation, pruning, abrupt tapering, and tortuosity of PAs occur, but whether different @entity1 have distinct PA phenotypes is unknown. Pulmonary arteriograms from 41 pediatric @entity1 with @entity120 were blindly reviewed by four experts who assigned each angiogram one of three designations: straight (S), tortuous (T), or ambiguous (A). Hemodynamic variables and outcomes were compared to the phenotypes. Thirty @entity1 were either T (19) or S (11); 11 were A. The phenotypes were not associated with age. Tortuous @entity1 had higher PA pressure and resistance than the S group and less likely to react to inhaled @entity842 than S @entity1 (p < 0.05). Clinical outcomes were similar for the three groups. Thus, in @entity120 @entity1 two subtypes of PA morphology can often be discerned, a reflection of variability in PA tortuosity. These morphological subtypes have differing hemodynamic characteristics. The mechanism(s) underlying these differences is unknown, but neither hydrodynamic factors nor duration of @entity120 are fully explanatory. Because PA morphology might reveal information regarding the biology of pathological remodeling, it might prove enlightening to assess the large PA phenotype in future studies of @entity120 .

title: XXXX : what the large pulmonary arteries tell us.

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension', 'PH']

answer: @entity120 :: (MESH:D006976,Disease) :: ['Pulmonary arterial hypertension']


abstract: BACKGROUND: Retrospective study about results of treatment of @entity1 (pts) with primary ( @entity1582 ) and secondary (AA) @entity2783 is given. 31 pts with systemic forms of @entity2783 have been treated and followed-up in our department since 1993. METHODS AND RESULTS: 6 @entity1 and 11 @entity1 were in the @entity1582 group with the mean age of 59 years. @entity1582 was diagnosed in 9 pts, @entity8058 ( @entity8058 ) was found in 8 pts. The kidneys were affected in all pts, heart in 59% of pts, @entity409 and skin in 26% of pts and @entity305 was detected only in 1 pt. Progression of @entity177 with decrease of glomerular filtration rate (GFR) was detected in the @entity1582 group at the end of follow-up period compared with the initial level (p < 0.05) despite the intensive treatment. The difference did not reach statistical significance in other investigated parameters. Median of survival was 13 months from the assessment of diagnosis. Partial remission of @entity2783 was achieved in 9 pts, stable disease was in 5 pts and in 3 pts the disease progressed. 4 @entity1 and 10 @entity1 were in the AA group with mean age of 58 years. Underlying disease was @entity309 in 7 pts, @entity1691 in 2 pts, @entity4932 in 1 pt, @entity30 in 2 pts, @entity19272 in 1 pt and chronic @entity1358 in 1 pt. The kidneys were affected in all pts, bowels and heart in 36% of pts. GFR (p < 0.05) and plasma @entity1011 (p < 0.01) significantly decreased at the end of follow-up period compared with initial levels. Median of survival was 30 months. Partial remission was achieved in 2 pts, stable disease was in 3 pts and progression was detected in 9 pts despite the use of various treatment regimens. CONCLUSIONS: Both forms of @entity1582 represent severe disease with limited response to treatment. The use of new drugs is promising and could lead to better response to treatment.

title: [Is the current treatment of primary and secondary XXXX effective?].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity8058 :: ('MESH:D008998', 'Disease') :: ['MGUS', 'monoclonal gammapathy of undetermined significance']

entities_list: @entity2783 :: ('MESH:D000686', 'Disease') :: ['amyloidosis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver, joints']

entities_list: @entity305 :: ('MESH:D011115', 'Disease') :: ['polyneuropathy']

entities_list: @entity4932 :: ('MESH:D001171', 'Disease') :: ['juvenile chronic arthritis']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['systemic amyloidosis', 'AL', 'Multiple myeloma']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['ankylosing spondylitis']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['abscesses in NK cell deficiency']

entities_list: @entity19272 :: ('MESH:C562487', 'Disease') :: ['eosinophilic fasciitis']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

answer: @entity2783 :: (MESH:D000686,Disease) :: ['amyloidosis']