abstract: OBJECTIVE: To explore the relationship between continuous @entity882 and @entity295 in @entity1 with severe burns. METHODS: Clinical data of 148 severely @entity4808 @entity1 admitted to our,two burn centers from January 2007 to December 2011 and conforming to the study criteria were retrospectively analyzed. All @entity1 were divided into @entity295 group (n =44) and non- @entity295 group (n = 104) according to the presence or absence of @entity295 within @entity4808 ( @entity4808 ) 30. The data of age, gender, total burn area, full-thickness burn area, fluid infusion volume within post burn hour (PBH) 24, plasma concentration of calcium ion on @entity4808 1, plasma concentration of albumin on @entity4808 1, platelet count on @entity4808 1, acute physiology and chronic health evaluation (APACHE) II score on admission, the presence or absence of @entity1457 or @entity130 on admission, the presence or absence of @entity5642 ( @entity5642 ) within PBH 48, operation or no operation within @entity4808 3, @entity882 duration within @entity4808 10, and mortality were statistically compared between two groups to screen the independent risk factors of @entity295 . Data were processed with t test, chi-square test, single factor Logistic regression analysis, and multi-factor Logistic regression analysis. RESULTS: Between two groups, there were statistically significant differences in total burn area, full-thickness burn area, plasma concentration of calcium ion on @entity4808 1, plasma concentration of albumin on @entity4808 1, APACHE II score on admission, presence or absence of hypovolem- ic shock on admission, presence or absence of @entity130 on admission, presence or absence of @entity5642 within PBH 48, and mortality (with t values from 2.433 to 4.082,   2 values from 8. 818 to 31.528, P < 0.05 or P < 0.01). Furthermore, the duration of @entity882 within @entity4808 10 in @entity295 group was (5.2    2.4) d, which was significantly longer than that in non- @entity295 group [(2.9    1.9) d, t =6. 189, P <0.01]. There were no statistically significant differences in the other indexes between two groups (with t values from 0.971 to 1. 250,   2 values respectively 0. 054 and 1.529, P values above 0.05). Single factor and multi-factor Logistic regression analysis indicated that APACHE II score on admission and duration of @entity882 within @entity4808 10 were closely related to occurrence of @entity295 (with odds ratio respectively 1. 140 and 1.569, P values below 0.01). CONCLUSIONS: Duration of @entity882 within @entity4808 10 is one of the risk factors for @entity295 in severely @entity4808 @entity1 , which can reflect pathophysiological changes in the body, thus providing predictive value for the occurrence of @entity295 .

title: [Clinical significance of continuous XXXX in predicting @entity295 after severe burn].

answer: @entity882 :: (MESH:D013921,Disease) :: ['thrombocytopenia']


abstract: OBJECTIVE: To identify potential neuromuscular factors associated with dynamic balance in individuals with @entity626 ( @entity571 ). DESIGN: Cross-sectional observational study; backward stepwise multiple linear regression was used to identify factors associated with dynamic balance in 2 statistical models. SETTING: University clinical research laboratory. @entity1 : Individuals aged >= 50 years (N=52) with osteoarthritic changes on radiograph participated. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Dynamic balance was assessed using the Community Balance and Mobility Scale (CB_M). Potentially modifiable neuromuscular factors associated with dynamic balance were measured, including the sum of concentric and eccentric lower-extremity muscle strength, 2 quadriceps-hamstrings muscle strength ratios, @entity3325 (joint position sense), anticipatory postural control velocity, and knee joint range of motion. RESULTS: The first model for explaining variance in CB_M scores consisted of eccentric lower-extremity muscle strength and knee joint range of motion as factors. The model containing these 2 variables explained 50% of the variance in CB_M scores. The second model adjusted for descriptive variables, including age, body mass index, and knee @entity158 , contained only the neuromuscular variables eccentric lower-extremity muscle strength, and explained 68% of the variance in CB_M scores. CONCLUSIONS: These results suggest that muscle strength and, to a lesser extent, knee joint range of motion are important factors associated with dynamic balance as measured by the CB_M and should be considered in dynamic balance interventions.

title: Factors Associated With Dynamic Balance in @entity1 With XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS']

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis']

entities_list: @entity3325 :: ('MESH:D020886', 'Disease') :: ['knee joint proprioception']

answer: @entity626 :: (MESH:D020370,Disease) :: ['Knee Osteoarthritis']


abstract: OBJECTIVE: To identify potential neuromuscular factors associated with dynamic balance in individuals with @entity626 ( @entity571 ). DESIGN: Cross-sectional observational study; backward stepwise multiple linear regression was used to identify factors associated with dynamic balance in 2 statistical models. SETTING: University clinical research laboratory. @entity1 : Individuals aged >= 50 years (N=52) with osteoarthritic changes on radiograph participated. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Dynamic balance was assessed using the Community Balance and Mobility Scale (CB_M). Potentially modifiable neuromuscular factors associated with dynamic balance were measured, including the sum of concentric and eccentric lower-extremity muscle strength, 2 quadriceps-hamstrings muscle strength ratios, @entity3325 (joint position sense), anticipatory postural control velocity, and knee joint range of motion. RESULTS: The first model for explaining variance in CB_M scores consisted of eccentric lower-extremity muscle strength and knee joint range of motion as factors. The model containing these 2 variables explained 50% of the variance in CB_M scores. The second model adjusted for descriptive variables, including age, body mass index, and knee @entity158 , contained only the neuromuscular variables eccentric lower-extremity muscle strength, and explained 68% of the variance in CB_M scores. CONCLUSIONS: These results suggest that muscle strength and, to a lesser extent, knee joint range of motion are important factors associated with dynamic balance as measured by the CB_M and should be considered in dynamic balance interventions.

title: Factors Associated With Dynamic Balance in XXXX With @entity626 .

answer: @entity1 :: (9606,Species) :: ['People']


abstract: PURPOSE: A pneumatic tourniquet is commonly used in total knee arthroplasty (TKA) to improve surgical field visualisation but may result in @entity121 muscle ischaemia. We performed this study to analyse the effect of the tourniquet on recovery following TKA. MATERIALS AND METHODS: A prospective randomised single-blinded trial was undertaken to examine the effect of the tourniquet on post-operative @entity158 , @entity4 , @entity190 , @entity121 function and outcome following TKA. Twenty @entity1 with @entity571 of the knee were randomised to tourniquet or no tourniquet groups. Quadriceps function was assessed using surface electromyography (EMG) during active knee extension. RESULTS: The no tourniquet group had significantly less @entity158 in the early post-operative period compared to the tourniquet group. There was no difference in Oxford knee score, range of motion, or thigh and knee @entity4 up to 12 months post-operatively. Quadriceps function, measured by surface EMG, was compromised for the first six months post-surgery by tourniquet use. The radiological cement mantle at the bone prosthesis interface at 12-month follow-up was not affected by the absence of a tourniquet. CONCLUSIONS: We believe that it is safe and beneficial for our @entity1 to routinely perform TKA without a tourniquet.

title: Effects of tourniquet use on XXXX function and @entity158 in total knee arthroplasty.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['quadriceps']

answer: @entity121 :: (MESH:D009135,Disease) :: ['quadriceps']


abstract: PURPOSE: A pneumatic tourniquet is commonly used in total knee arthroplasty (TKA) to improve surgical field visualisation but may result in @entity121 muscle ischaemia. We performed this study to analyse the effect of the tourniquet on recovery following TKA. MATERIALS AND METHODS: A prospective randomised single-blinded trial was undertaken to examine the effect of the tourniquet on post-operative @entity158 , @entity4 , @entity190 , @entity121 function and outcome following TKA. Twenty @entity1 with @entity571 of the knee were randomised to tourniquet or no tourniquet groups. Quadriceps function was assessed using surface electromyography (EMG) during active knee extension. RESULTS: The no tourniquet group had significantly less @entity158 in the early post-operative period compared to the tourniquet group. There was no difference in Oxford knee score, range of motion, or thigh and knee @entity4 up to 12 months post-operatively. Quadriceps function, measured by surface EMG, was compromised for the first six months post-surgery by tourniquet use. The radiological cement mantle at the bone prosthesis interface at 12-month follow-up was not affected by the absence of a tourniquet. CONCLUSIONS: We believe that it is safe and beneficial for our @entity1 to routinely perform TKA without a tourniquet.

title: Effects of tourniquet use on @entity121 function and XXXX in total knee arthroplasty.

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: We report a rare case of a @entity356 treated with endoscopic resection and oral @entity2816 therapy. A 70-year-old @entity1 was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The @entity1 was diagnosed with extramedullary @entity356 . Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The @entity1 's condition was found to be stable.

title: Successful treatment of a @entity356 using a combination of endoscopic submucosal dissection and oral XXXX .

entities_list: @entity2816 :: ('MESH:D013792', 'Chemical') :: ['thalidomide']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric plasmacytoma']

answer: @entity2816 :: (MESH:D013792,Chemical) :: ['thalidomide']


abstract: We report a rare case of a @entity356 treated with endoscopic resection and oral @entity2816 therapy. A 70-year-old @entity1 was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The @entity1 was diagnosed with extramedullary @entity356 . Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The @entity1 's condition was found to be stable.

title: Successful treatment of a XXXX using a combination of endoscopic submucosal dissection and oral @entity2816 .

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric plasmacytoma']


abstract: PURPOSE: To compare the clinical usefulness of reduced field-of-view diffusion-weighted imaging (rFOV) with other imaging techniques in determining the depth of @entity3 (DMI) in @entity1204 . MATERIALS AND METHODS: In this prospective study we reviewed 3T magnetic resonance images of 51 @entity1 with clinical Stage I @entity1204 who underwent total abdominal hysterectomy with bilateral salphingoopherectomy within 3 days after imaging. rFOV with apparent diffusion coefficient reconstruction was obtained in three standard planes followed by sagittal T2 -weighted (T2 WI) images and 3D dynamic T1 -weighted and contrast-enhanced imaging ( @entity9243 MRI). Two radiologists with expertise in imaging gynecologic cancers evaluated images independently. The DMI was recorded on imaging and correlated with surgical pathology results. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DMI were calculated (<50% vs. >50%). RESULTS: Compared with sagittal T2 WI   +   @entity9243 MRI, rFOV imaging yielded greater specificity (82.2% vs. 90.0%, positive predictive value (42.8% vs. 60.0%), and accuracy (84.0% vs. 92%) for DMI determined by reader 1 and greater the sensitivity (83.3% vs. 100%) for DMI determined by reader 2. The error of measurement of DMI as a continuous variable in millimeters did not differ significantly between the rFOV and pathology results (P < 0.21). However, there was a statistically significant difference for the DMI measured on the dynamic sequence. The DMI on @entity9243 was greater than that seen on pathology at P   =   0.02. CONCLUSION: rFOV can be used to assess DMI in clinical Stage I @entity1204 . J. Magn. Reson. Imaging 2015.

title: Feasibility of a reduced field-of-view diffusion-weighted (rFOV) sequence in assessment of XXXX in @entity1 with clinical FIGO stage I @entity1204 .

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['myometrial invasion']

answer: @entity3 :: (MESH:D009362,Disease) :: ['myometrial invasion']


abstract: PURPOSE: To compare the clinical usefulness of reduced field-of-view diffusion-weighted imaging (rFOV) with other imaging techniques in determining the depth of @entity3 (DMI) in @entity1204 . MATERIALS AND METHODS: In this prospective study we reviewed 3T magnetic resonance images of 51 @entity1 with clinical Stage I @entity1204 who underwent total abdominal hysterectomy with bilateral salphingoopherectomy within 3 days after imaging. rFOV with apparent diffusion coefficient reconstruction was obtained in three standard planes followed by sagittal T2 -weighted (T2 WI) images and 3D dynamic T1 -weighted and contrast-enhanced imaging ( @entity9243 MRI). Two radiologists with expertise in imaging gynecologic cancers evaluated images independently. The DMI was recorded on imaging and correlated with surgical pathology results. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DMI were calculated (<50% vs. >50%). RESULTS: Compared with sagittal T2 WI   +   @entity9243 MRI, rFOV imaging yielded greater specificity (82.2% vs. 90.0%, positive predictive value (42.8% vs. 60.0%), and accuracy (84.0% vs. 92%) for DMI determined by reader 1 and greater the sensitivity (83.3% vs. 100%) for DMI determined by reader 2. The error of measurement of DMI as a continuous variable in millimeters did not differ significantly between the rFOV and pathology results (P < 0.21). However, there was a statistically significant difference for the DMI measured on the dynamic sequence. The DMI on @entity9243 was greater than that seen on pathology at P   =   0.02. CONCLUSION: rFOV can be used to assess DMI in clinical Stage I @entity1204 . J. Magn. Reson. Imaging 2015.

title: Feasibility of a reduced field-of-view diffusion-weighted (rFOV) sequence in assessment of @entity3 in @entity1 with clinical FIGO stage I XXXX .

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']


abstract: PURPOSE: To compare the clinical usefulness of reduced field-of-view diffusion-weighted imaging (rFOV) with other imaging techniques in determining the depth of @entity3 (DMI) in @entity1204 . MATERIALS AND METHODS: In this prospective study we reviewed 3T magnetic resonance images of 51 @entity1 with clinical Stage I @entity1204 who underwent total abdominal hysterectomy with bilateral salphingoopherectomy within 3 days after imaging. rFOV with apparent diffusion coefficient reconstruction was obtained in three standard planes followed by sagittal T2 -weighted (T2 WI) images and 3D dynamic T1 -weighted and contrast-enhanced imaging ( @entity9243 MRI). Two radiologists with expertise in imaging gynecologic cancers evaluated images independently. The DMI was recorded on imaging and correlated with surgical pathology results. Sensitivity, specificity, positive predictive value, negative predictive value, and accuracy for DMI were calculated (<50% vs. >50%). RESULTS: Compared with sagittal T2 WI   +   @entity9243 MRI, rFOV imaging yielded greater specificity (82.2% vs. 90.0%, positive predictive value (42.8% vs. 60.0%), and accuracy (84.0% vs. 92%) for DMI determined by reader 1 and greater the sensitivity (83.3% vs. 100%) for DMI determined by reader 2. The error of measurement of DMI as a continuous variable in millimeters did not differ significantly between the rFOV and pathology results (P < 0.21). However, there was a statistically significant difference for the DMI measured on the dynamic sequence. The DMI on @entity9243 was greater than that seen on pathology at P   =   0.02. CONCLUSION: rFOV can be used to assess DMI in clinical Stage I @entity1204 . J. Magn. Reson. Imaging 2015.

title: Feasibility of a reduced field-of-view diffusion-weighted (rFOV) sequence in assessment of @entity3 in XXXX with clinical FIGO stage I @entity1204 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE OF THE STUDY: Nonpharmacological, psychosocial approaches are first-line treatments for managing behavioral symptoms in @entity303 , but they can be challenging to implement in long-term care settings. The Veterans Health Administration implemented STAR-VA, an interdisciplinary behavioral approach for managing challenging @entity303 -related behaviors in its Community Living Center (CLCs, nursing home care) settings. This study describes how the program was implemented and provides an evaluation of Veteran clinical outcomes and staff feedback on the intervention. DESIGN AND METHODS: One mental health professional and registered nurse team from 17 CLCs completed STAR-VA training, which entailed an experiential workshop followed by 6 months of expert consultation as they worked with their teams to implement STAR-VA with Veterans identified to have challenging @entity303 -related behaviors. The frequency and severity of @entity146 and symptoms of @entity308 , @entity148 , and @entity2146 were evaluated at baseline and at intervention completion. Staff provided feedback regarding STAR-VA feasibility and impact. RESULTS: Seventy-one Veterans completed the intervention. Behaviors clustered into 6 types: care refusal or resistance, @entity2146 , @entity146 , vocalization, wandering, and other. Frequency and severity of @entity146 and symptoms of @entity308 , @entity148 , and @entity2146 all significantly decreased, with overall effect sizes of 1 or greater. Staff rated both benefits for Veterans and program feasibility favorably. IMPLICATIONS: This evaluation supports the feasibility and effectiveness of STAR-VA, an interdisciplinary, behavioral intervention for managing @entity146 among residents with @entity303 in CLCs.

title: Effectiveness of Expanded Implementation of STAR-VA for Managing XXXX -Related Behaviors Among Veterans.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression', 'challenging behaviors', 'target behaviors']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation']

answer: @entity303 :: (MESH:D003704,Disease) :: ['Dementia']


abstract: AIM: The aim of this study was to analyse the influence of birthweight on motor performance and body composition in @entity1 . Further, we investigated whether associations between birthweight and motor performance changed after adjustment for current height, body mass index (BMI), @entity1386 ( @entity1386 ), and % body fat. METHOD: A total of 483 @entity1 (251 males and 232 females) aged 7 to 10  years (mean 8.78, SD 1.0y) born in Vit  ria Santo Ant  o (northeast Brazil) were sampled. Motor performance was operationalized using different physical fitness components and gross motor coordination. Physical fitness was measured by handgrip strength, muscle endurance, explosive power, flexibility, agility, running speed, and maximal @entity26 consumption (VO2max ). Gross motor coordination was evaluated by means of the K  rper Koordination Test f  r Kinder (KTK). RESULTS: Positive correlations between birthweight and height, BMI, and @entity1386 were found. Birthweight was positively correlated with handgrip strength and negatively correlated with 20-meter sprint time, even after controlling for age, height, BMI, @entity1386 , and % body fat. Birthweight was negatively associated with relative VO2max (mL/kg/min); however, the association was no longer significant after inclusion of BMI or @entity1386 in the model. INTERPRETATION: Birthweight significantly predicted height, BMI, @entity1386 , and performance in strength and velocity tests, but did not influence gross motor coordination.

title: Birthweight, body composition, and motor performance in 7- to 10-year-old XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['FFM', 'fat-free mass']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: -Exercise training has been shown to improve @entity410 , physical capacity and quality of life in @entity1 with cardiopulmonary conditions such as @entity712 and @entity1030 . However, its role in management of @entity120 is not well defined. In this study, we aim to evaluate the efficacy and safety of exercise training in @entity1 with @entity120 . METHODS AND RESULTS: -We included all prospective intervention studies that evaluated the efficacy and safety of exercise training in @entity1 with @entity120 . Primary outcome of this meta-analysis was a change in six-minute walk distance (6MWD). We also assessed the effect of exercise on peak @entity26 uptake (VO2peak), resting pulmonary arterial systolic pressure (PASP), peak exercise heart rate (HRpeak), and quality of life. A total of 16 studies with 434 exercise-training @entity1 were included. In the pooled analysis, exercise training was associated with significant improvement in 6MWD [Weighted mean difference (WMD): 57.7 meters (95% CI: 42.5 to 72.8)], VO2peak [WMD = 1.7 ml/kg/min (95% CI: 1.3 to 2.0)], PASP [WMD = -3.6 mmHg (95% CI = -5.8 to -1.4)], HRpeak [WMD = 10.4 beats per min (95% CI: 5.5 to 15.3)], and quality of life as measured on SF-36 questionnaire subscale scores. Furthermore, exercise training was well tolerated with a low dropout rate and no major adverse events related to exercise training. CONCLUSIONS: -Exercise training in @entity1 with @entity120 appears safe and is associated with a significant improvement in exercise capacity, pulmonary arterial pressure and quality of life.

title: Efficacy and Safety of Exercise Training in XXXX : A Systematic Review and Meta-Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['cardiorespiratory fitness']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

answer: @entity120 :: (MESH:D006976,Disease) :: ['Chronic Pulmonary Hypertension']


abstract: BACKGROUND: We sought to evaluate the impact of the evolution of a pediatric @entity1457 ( @entity1457 ) program on outcomes of @entity1 listed for heart transplantation at our institution. METHODS: All @entity1 listed for isolated heart transplantation from 1995 to 2013 were included. The use of @entity1457 while on the wait-list was recorded. Wait-list and posttransplant outcomes were compared before and after 2005, which was when we became capable of providing long-term @entity1457 without size limitation. RESULTS: In total, 259 @entity1 were listed for transplant and 201 (78%) reached transplant. The use of @entity1457 was significantly increased between the eras (13% and 37%, p  = 0.0001). Wait-list mortality was significantly decreased (25% and 11%, p  = 0.0006). Among transplant recipients, the proportion of @entity1 who underwent @entity1457 was significantly increased (13% and 37%, p  = 0.0002). Of these @entity1457 @entity1 , the use of long-term devices was significantly increased (50% and 98%, p  = 0.0004). Median duration of @entity1457 was significantly increased (12 and 78 days, p  = 0.004). Kaplan-Meier estimates showed a trend (p  = 0.08) toward improved survival after bridge-to-transplant both at 1 year (70% in the early @entity7971 and 88% in the late @entity7971 ) and at 5 years (60% and 78%, respectively). CONCLUSIONS: Outcomes of pediatric heart transplantation have significantly improved over the last 2 decades. We believe such improvement is, at least in part, attributable to maturation of @entity1457 strategy, characterized by avoiding the use of temporary devices such as extracorporeal membrane oxygenation as a bridge-to-transplant and a more aggressive use of long-term devices.

title: Evolution and Impact of Ventricular Assist Device Program on XXXX Awaiting Heart Transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['mechanical circulatory support', 'MCS']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: @entity3 remains associated with significant morbidity and mortality, necessitating new options for salvage therapy. The objective of this study was to evaluate the efficacy and safety of @entity1331 as salvage monotherapy in @entity1 with @entity3 . @entity1 with proven or probable @entity3 , who were refractory or intolerant to previous systemic antifungal therapy, were randomised 2  :  1 to receive 300  mg  day(-1) intravenous @entity1331 monotherapy or an intravenous control monotherapy [lipid @entity2379 (5  mg  kg(-1)   day(-1) ), @entity5074 (8  mg  kg(-1)   day(-1) ) or @entity11794 (50  mg  day(-1) )] for 3-12  weeks. @entity1 underwent final assessment 12  weeks after treatment start. Seventeen @entity1 with @entity3 (proven, n  =  2; probable, n  =  14; not recorded, n  =  1) participated in the study ( @entity1331 arm, n  =  12; control arm, n  =  5). Three @entity1 each in the @entity1331 (25.0%; 95% CI: 5.5-57.2) and control arm (60.0%; 95% CI: 14.7-94.7) had successful therapy at end of treatment as assessed by an Independent Data Review Board. Eleven @entity1 died; six due to @entity3 . No @entity204 were considered related to study treatment. During this study it became increasingly common to use combination treatment for salvage therapy. Consequently, enrolment was low and the study was discontinued early. No clear trends in efficacy and safety can be concluded.

title: Randomised, multicentre trial of XXXX vs. an institutional standard regimen for salvage treatment of @entity3 .

entities_list: @entity1331 :: ('MESH:C121905', 'Chemical') :: ['micafungin']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity5074 :: ('MESH:C102790', 'Chemical') :: ['voriconazole']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive aspergillosis', 'Invasive aspergillosis']

entities_list: @entity11794 :: ('MESH:C105417', 'Chemical') :: ['caspofungin']

answer: @entity1331 :: (MESH:C121905,Chemical) :: ['micafungin']


abstract: @entity3 remains associated with significant morbidity and mortality, necessitating new options for salvage therapy. The objective of this study was to evaluate the efficacy and safety of @entity1331 as salvage monotherapy in @entity1 with @entity3 . @entity1 with proven or probable @entity3 , who were refractory or intolerant to previous systemic antifungal therapy, were randomised 2  :  1 to receive 300  mg  day(-1) intravenous @entity1331 monotherapy or an intravenous control monotherapy [lipid @entity2379 (5  mg  kg(-1)   day(-1) ), @entity5074 (8  mg  kg(-1)   day(-1) ) or @entity11794 (50  mg  day(-1) )] for 3-12  weeks. @entity1 underwent final assessment 12  weeks after treatment start. Seventeen @entity1 with @entity3 (proven, n  =  2; probable, n  =  14; not recorded, n  =  1) participated in the study ( @entity1331 arm, n  =  12; control arm, n  =  5). Three @entity1 each in the @entity1331 (25.0%; 95% CI: 5.5-57.2) and control arm (60.0%; 95% CI: 14.7-94.7) had successful therapy at end of treatment as assessed by an Independent Data Review Board. Eleven @entity1 died; six due to @entity3 . No @entity204 were considered related to study treatment. During this study it became increasingly common to use combination treatment for salvage therapy. Consequently, enrolment was low and the study was discontinued early. No clear trends in efficacy and safety can be concluded.

title: Randomised, multicentre trial of @entity1331 vs. an institutional standard regimen for salvage treatment of XXXX .

answer: @entity3 :: (MESH:D009362,Disease) :: ['invasive aspergillosis']


abstract: INTRODUCTION: @entity6817 may induce @entity409 of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for @entity2336 syndrome/ @entity2335 (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study. SUBJECTS AND METHODS: This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls. RESULTS: A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for @entity6 , @entity101 , @entity301 , @entity28 , chronic @entity2371 , @entity1744 , @entity239 , @entity5815 , @entity308 , @entity4697 , @entity2704 , @entity10632 , @entity566 , @entity46 , and @entity565 . Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls. CONCLUSION: We concluded that there was an association between statin use and BPS/IC.    2015 S. Karger AG, Basel.

title: Statin Use Is Associated with @entity2336 Syndrome/ XXXX : A Population-Based Case-Control Study.

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity4697 :: ('MESH:D016584', 'Disease') :: ['panic disorder']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergies']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['epithelial dysfunction']

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain']

entities_list: @entity2336 :: ('MESH:D018856', 'Disease') :: ['bladder pain']

entities_list: @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraines']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['irritable bowel syndrome']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity5815 :: ('MESH:D015673', 'Disease') :: ['chronic fatigue syndrome']

entities_list: @entity10632 :: ('MESH:D012859', 'Disease') :: ['sicca syndrome']

entities_list: @entity2335 :: ('MESH:D003556', 'Disease') :: ['interstitial cystitis']

answer: @entity2335 :: (MESH:D003556,Disease) :: ['Interstitial Cystitis']


abstract: INTRODUCTION: @entity6817 may induce @entity409 of the bladder urothelium. Epithelial dysfunction was proposed as one of the major potential etiologies for @entity2336 syndrome/ @entity2335 (BPS/IC). In this study, we examined the association between statin use and BPS/IC using a population-based study. SUBJECTS AND METHODS: This case-control study used the Taiwan Longitudinal Health Insurance Database. In total, 815 female subjects with BPS/IC and 4075 randomly selected female controls were included. We used a conditional logistic regression to compute the odds ratio (OR) for having previously used statins between cases and controls. RESULTS: A conditional logistic regression analysis showed that the OR of prior statin users for cases was 1.52 (95% confidence interval (CI): 1.19-1.94) compared to controls after adjusting for @entity6 , @entity101 , @entity301 , @entity28 , chronic @entity2371 , @entity1744 , @entity239 , @entity5815 , @entity308 , @entity4697 , @entity2704 , @entity10632 , @entity566 , @entity46 , and @entity565 . Furthermore, adjusted ORs of regular and irregular statin use for cases were 1.58 (95% CI: 1.20-2.08) and 1.53 (95% CI: 1.02-2.31), respectively, compared to controls. CONCLUSION: We concluded that there was an association between statin use and BPS/IC.    2015 S. Karger AG, Basel.

title: Statin Use Is Associated with XXXX Syndrome/ @entity2335 : A Population-Based Case-Control Study.

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia']

answer: @entity2336 :: (MESH:D018856,Disease) :: ['Bladder Pain']


abstract: BACKGROUND: The objective of this prospective cohort study was to assess whether the 45-minute prehospital limit for ambulance transfer is met in case of postpartum @entity548 (PPH) after midwifery-supervised home birth in The Netherlands and evaluate the process of ambulance transfer, maternal condition during transfer, and outcomes in relation to whether this limit was met. METHODS: Using ambulance report forms and medical charts, ambulance intervals, urgency coding, clinical condition (using the lowest Revised @entity130 Score, [RTS]), and maternal outcomes were collected. From April 2008 to April 2010, midwives reported 72 cases of PPH. Associations between duration of the ambulance transfer, maternal condition during ambulance transfer and outcomes were analyzed. The main outcome measures were duration of ambulance transfer, RTS, @entity190 , surgical procedures, and blood transfusions. RESULTS: Seventy-two cases were reported, 18 (25%) were excluded: 54 cases were analyzed. In 63 percent, the 45-minute prehospital limit was met, 75.9 percent received a RTS of 12, indicating optimal Glasgow @entity772 Scale, systolic blood pressure, and respiratory frequency. In 24.1 percent a @entity551 was found (RTS 10 or 11). We found no difference in outcomes between @entity1 with different RTS or in whom the 45-minute prehospital limit was or was not met. CONCLUSIONS: We found no relation between the duration of ambulance transfer and maternal condition or outcomes. All @entity1 fully recovered. The low-risk profile of @entity1 in primary care, well-organized midwifery, and ambulance care in The Netherlands are likely to contribute to these findings.

title: Ambulance Transfer in Case of Postpartum XXXX after Birth in Primary Midwifery Care in The Netherlands: A Prospective Cohort Study.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['decrease in systolic blood pressure']

answer: @entity548 :: (MESH:D006470,Disease) :: ['Hemorrhage']


abstract: OBJECTIVE: To evaluate the prevalence and to classify @entity1069 on transrectal ultrasonography (TRUS) and correlate the findings with histology. METHODS: A prospective, blinded study of @entity1 undergoing TRUS and prostatic biopsy was designed. A standardized reproducible technique was used with a BK 7.5- to 12.5-MHz multiplanar probe. Representative images of the @entity730 in the sagittal and transverse planes were captured. Blind analysis by an experienced observer was performed. TRUS findings were categorized using a novel classification and correlated with histologic data. RESULTS: A total of 274 @entity1 (58.8%) had @entity263 , 88 @entity1 (18.9%) @entity32 , and 104 @entity1 (22.3%) had benign pathology. Interface @entity730 was present in 42.3% of @entity1 . Peripheral or transitional zone @entity730 was unusual (6.8% and 9.0%, respectively). Of the  peripheral zone @entity730 group @entity1 , 78.1% had @entity5 on histology examination (P  =  .020). CONCLUSION: Prevalence and characteristics of @entity1069 have been described using this novel and practical classification. Although interface @entity730 is common and not associated with any particular pathology, peripheral zone @entity730 appears to be strongly associated with @entity263 .

title: Prevalence of @entity1069 subtypes and association with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity1069 :: ('MESH:D053448', 'Disease') :: ['prostatic calcification']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: OBJECTIVE: To evaluate the prevalence and to classify @entity1069 on transrectal ultrasonography (TRUS) and correlate the findings with histology. METHODS: A prospective, blinded study of @entity1 undergoing TRUS and prostatic biopsy was designed. A standardized reproducible technique was used with a BK 7.5- to 12.5-MHz multiplanar probe. Representative images of the @entity730 in the sagittal and transverse planes were captured. Blind analysis by an experienced observer was performed. TRUS findings were categorized using a novel classification and correlated with histologic data. RESULTS: A total of 274 @entity1 (58.8%) had @entity263 , 88 @entity1 (18.9%) @entity32 , and 104 @entity1 (22.3%) had benign pathology. Interface @entity730 was present in 42.3% of @entity1 . Peripheral or transitional zone @entity730 was unusual (6.8% and 9.0%, respectively). Of the  peripheral zone @entity730 group @entity1 , 78.1% had @entity5 on histology examination (P  =  .020). CONCLUSION: Prevalence and characteristics of @entity1069 have been described using this novel and practical classification. Although interface @entity730 is common and not associated with any particular pathology, peripheral zone @entity730 appears to be strongly associated with @entity263 .

title: Prevalence of XXXX subtypes and association with @entity263 .

answer: @entity1069 :: (MESH:D053448,Disease) :: ['prostatic calcification']


abstract: OBJECTIVE: To determine the efficacy of @entity22785 applied early after @entity130 for preventing @entity32 and spongiofibrosis. MATERIALS AND METHODS: Twenty-seven @entity35 were randomized and divided into 3 groups, with 9 @entity35 in each group. The urethras of all @entity35 were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14  days, group I was given 0.9% saline twice a day (control group), group II was given @entity22785 500  mg/kg ampules once a day and 0.9% saline once a day, and group III was given @entity22785 500  mg/kg ampules twice a day intraurethrally using a 22  ga catheter sheath. On day 15, the penises of the @entity35 were degloved to perform penectomy. RESULTS: The mean @entity82 scores were 2.4, 2.2, and 1.4, and mean @entity32 scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for @entity32 (P  = .011); however, the difference for @entity82 was not significant (P  = .331). The differences between groups I and III were statistically significantly different both for @entity32 and @entity82 (P  = .004 and P  = .003, respectively). Groups II and III were not different significantly for @entity32 (P  = .638); however, there was less @entity82 in group III, in which high-dose @entity22785 was administered. CONCLUSION: We showed that @entity22785 applied early after @entity130 significantly decreased @entity32 and spongiofibrosis. We hope that our study will help to decrease strictures after @entity130 and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.

title: The effect of intraurethral @entity22785 on healing and XXXX in @entity35 with experimentally induced @entity130 .

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity22785 :: ('MESH:C007288', 'Chemical') :: ['dexpanthenol']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['urethral trauma']

answer: @entity82 :: (MESH:D005355,Disease) :: ['fibrosis']


abstract: OBJECTIVE: To determine the efficacy of @entity22785 applied early after @entity130 for preventing @entity32 and spongiofibrosis. MATERIALS AND METHODS: Twenty-seven @entity35 were randomized and divided into 3 groups, with 9 @entity35 in each group. The urethras of all @entity35 were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14  days, group I was given 0.9% saline twice a day (control group), group II was given @entity22785 500  mg/kg ampules once a day and 0.9% saline once a day, and group III was given @entity22785 500  mg/kg ampules twice a day intraurethrally using a 22  ga catheter sheath. On day 15, the penises of the @entity35 were degloved to perform penectomy. RESULTS: The mean @entity82 scores were 2.4, 2.2, and 1.4, and mean @entity32 scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for @entity32 (P  = .011); however, the difference for @entity82 was not significant (P  = .331). The differences between groups I and III were statistically significantly different both for @entity32 and @entity82 (P  = .004 and P  = .003, respectively). Groups II and III were not different significantly for @entity32 (P  = .638); however, there was less @entity82 in group III, in which high-dose @entity22785 was administered. CONCLUSION: We showed that @entity22785 applied early after @entity130 significantly decreased @entity32 and spongiofibrosis. We hope that our study will help to decrease strictures after @entity130 and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.

title: The effect of intraurethral @entity22785 on healing and @entity82 in @entity35 with experimentally induced XXXX .

answer: @entity130 :: (MESH:D014947,Disease) :: ['urethral trauma']


abstract: OBJECTIVE: To determine the efficacy of @entity22785 applied early after @entity130 for preventing @entity32 and spongiofibrosis. MATERIALS AND METHODS: Twenty-seven @entity35 were randomized and divided into 3 groups, with 9 @entity35 in each group. The urethras of all @entity35 were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14  days, group I was given 0.9% saline twice a day (control group), group II was given @entity22785 500  mg/kg ampules once a day and 0.9% saline once a day, and group III was given @entity22785 500  mg/kg ampules twice a day intraurethrally using a 22  ga catheter sheath. On day 15, the penises of the @entity35 were degloved to perform penectomy. RESULTS: The mean @entity82 scores were 2.4, 2.2, and 1.4, and mean @entity32 scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for @entity32 (P  = .011); however, the difference for @entity82 was not significant (P  = .331). The differences between groups I and III were statistically significantly different both for @entity32 and @entity82 (P  = .004 and P  = .003, respectively). Groups II and III were not different significantly for @entity32 (P  = .638); however, there was less @entity82 in group III, in which high-dose @entity22785 was administered. CONCLUSION: We showed that @entity22785 applied early after @entity130 significantly decreased @entity32 and spongiofibrosis. We hope that our study will help to decrease strictures after @entity130 and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.

title: The effect of intraurethral XXXX on healing and @entity82 in @entity35 with experimentally induced @entity130 .

answer: @entity22785 :: (MESH:C007288,Chemical) :: ['dexpanthenol']


abstract: OBJECTIVE: To determine the efficacy of @entity22785 applied early after @entity130 for preventing @entity32 and spongiofibrosis. MATERIALS AND METHODS: Twenty-seven @entity35 were randomized and divided into 3 groups, with 9 @entity35 in each group. The urethras of all @entity35 were traumatized with a pediatric urethrotome knife at 6-o' clock. For 14  days, group I was given 0.9% saline twice a day (control group), group II was given @entity22785 500  mg/kg ampules once a day and 0.9% saline once a day, and group III was given @entity22785 500  mg/kg ampules twice a day intraurethrally using a 22  ga catheter sheath. On day 15, the penises of the @entity35 were degloved to perform penectomy. RESULTS: The mean @entity82 scores were 2.4, 2.2, and 1.4, and mean @entity32 scar scores were 2, 1.4, and 1.3 in groups I, II, and III, respectively. There was a significant difference between groups I and II for @entity32 (P  = .011); however, the difference for @entity82 was not significant (P  = .331). The differences between groups I and III were statistically significantly different both for @entity32 and @entity82 (P  = .004 and P  = .003, respectively). Groups II and III were not different significantly for @entity32 (P  = .638); however, there was less @entity82 in group III, in which high-dose @entity22785 was administered. CONCLUSION: We showed that @entity22785 applied early after @entity130 significantly decreased @entity32 and spongiofibrosis. We hope that our study will help to decrease strictures after @entity130 and contribute to pharmaceutical investigations aiming to improve the success of the surgery for urethral strictures.

title: The effect of intraurethral @entity22785 on healing and @entity82 in XXXX with experimentally induced @entity130 .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: UNASSIGNED: @entity855 -binding cassette (ABC) transporters have been shown to be involved in pesticide detoxification in arthropod vectors and are thought to contribute to the development of drug resistance. Little is currently known about the role they play in ticks, which are among the more important vectors of @entity1 and animal pathogens. Here, the role of ABC transporters in the transport of @entity276 and ivermectin acaricides in the tick @entity278 (Ixodida: Ixodidae) was investigated. Larvae were treated with acaricide alone and acaricide in combination with a sub-lethal dose of the ABC transporter inhibitor @entity205 . The LC50 doses and 95% confidence intervals (CIs) estimated by mortality data using probit analysis were 67.930   p.p.m. (95% CI 53.780-90.861) for @entity276 and 3741   p.p.m. (95% CI 2857-4647) for ivermectin. The pre-exposure of larvae to a sub-lethal dose of @entity205 reduced the LC50 dose of @entity276 to 4.808   p.p.m. (95% CI 0.715-9.527) and that of ivermectin to 167   p.p.m. (95% CI 15-449), which increased @entity137 by about 14- and 22-fold, respectively. The comparison of mortality data for each separate @entity71807 concentration showed the synergic effect of @entity205 to be reduced at higher concentrations of acaricide. These results show for the first time a strong association between ABC transporters and acaricide detoxification in @entity278 s.l.

title: Potential role of @entity855 -binding cassette transporters against acaricides in the XXXX @entity278 sensu lato.

entities_list: @entity276 :: ('MESH:C082360', 'Chemical') :: ['fipronil']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity71807 :: ('CHEBI:22153', 'Chemical') :: ['acaricide']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A']

entities_list: @entity278 :: ('34632', 'Species') :: ['Rhipicephalus sanguineus', 'R.sanguineus']

answer: @entity278 :: (34632,Species) :: ['brown dog tick']


abstract: UNASSIGNED: @entity855 -binding cassette (ABC) transporters have been shown to be involved in pesticide detoxification in arthropod vectors and are thought to contribute to the development of drug resistance. Little is currently known about the role they play in ticks, which are among the more important vectors of @entity1 and animal pathogens. Here, the role of ABC transporters in the transport of @entity276 and ivermectin acaricides in the tick @entity278 (Ixodida: Ixodidae) was investigated. Larvae were treated with acaricide alone and acaricide in combination with a sub-lethal dose of the ABC transporter inhibitor @entity205 . The LC50 doses and 95% confidence intervals (CIs) estimated by mortality data using probit analysis were 67.930   p.p.m. (95% CI 53.780-90.861) for @entity276 and 3741   p.p.m. (95% CI 2857-4647) for ivermectin. The pre-exposure of larvae to a sub-lethal dose of @entity205 reduced the LC50 dose of @entity276 to 4.808   p.p.m. (95% CI 0.715-9.527) and that of ivermectin to 167   p.p.m. (95% CI 15-449), which increased @entity137 by about 14- and 22-fold, respectively. The comparison of mortality data for each separate @entity71807 concentration showed the synergic effect of @entity205 to be reduced at higher concentrations of acaricide. These results show for the first time a strong association between ABC transporters and acaricide detoxification in @entity278 s.l.

title: Potential role of @entity855 -binding cassette transporters against acaricides in the @entity278 XXXX sensu lato.

answer: @entity278 :: (34632,Species) :: ['Rhipicephalus sanguineus']


abstract: UNASSIGNED: @entity855 -binding cassette (ABC) transporters have been shown to be involved in pesticide detoxification in arthropod vectors and are thought to contribute to the development of drug resistance. Little is currently known about the role they play in ticks, which are among the more important vectors of @entity1 and animal pathogens. Here, the role of ABC transporters in the transport of @entity276 and ivermectin acaricides in the tick @entity278 (Ixodida: Ixodidae) was investigated. Larvae were treated with acaricide alone and acaricide in combination with a sub-lethal dose of the ABC transporter inhibitor @entity205 . The LC50 doses and 95% confidence intervals (CIs) estimated by mortality data using probit analysis were 67.930   p.p.m. (95% CI 53.780-90.861) for @entity276 and 3741   p.p.m. (95% CI 2857-4647) for ivermectin. The pre-exposure of larvae to a sub-lethal dose of @entity205 reduced the LC50 dose of @entity276 to 4.808   p.p.m. (95% CI 0.715-9.527) and that of ivermectin to 167   p.p.m. (95% CI 15-449), which increased @entity137 by about 14- and 22-fold, respectively. The comparison of mortality data for each separate @entity71807 concentration showed the synergic effect of @entity205 to be reduced at higher concentrations of acaricide. These results show for the first time a strong association between ABC transporters and acaricide detoxification in @entity278 s.l.

title: Potential role of XXXX -binding cassette transporters against acaricides in the @entity278 @entity278 sensu lato.

answer: @entity855 :: (MESH:D000255,Chemical) :: ['ATP']


abstract: @entity2910 is a rare @entity5 consisting of both @entity3909 , with an incidence of 0.5%. There have been only a few case reports of @entity6962 and @entity957 coexisting in the esophagus. However, all of these are cases of synchronous or metachronous development of @entity6962 after chemoradiotherapy in @entity1 of @entity1721 . A 53-year-old @entity1 underwent esophagogas-troduodenoscopy because of @entity662 for several months. Endoscopic examination revealed a huge pedunculated esophageal polypoid mass. Endoscopic submucosal dissection (ESD) was performed and histopathologic examination confirmed @entity189 ( @entity6962 ). He refused additional esophagectomy. After 21 months, third follow-up endoscopy showed poorly-demarcated flat, faint discolored lesions at different location from the previous ESD site and endoscopic biopsies confirmed @entity957 . To the best of our knowledge, this is the first case of metachronous development of @entity1721 in a @entity1 with @entity2910 . (Korean J Gastroenterol 2014;64:364-369).

title: A case of metachronous development of XXXX in the @entity1 with @entity2910 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant esophageal neoplasm']

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophageal carcinosarcoma', 'Esophageal carcinosarcoma']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity3909 :: ('MESH:D055756', 'Disease') :: ['carcinomatous and sarcomatous elements']

entities_list: @entity1721 :: ('MESH:C562729', 'Disease') :: ['esophageal squamous cell carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['spindle cell carcinoma']

entities_list: @entity6962 :: ('MESH:D002296', 'Disease') :: ['carcinosarcoma']

answer: @entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous cell carcinoma']


abstract: @entity2910 is a rare @entity5 consisting of both @entity3909 , with an incidence of 0.5%. There have been only a few case reports of @entity6962 and @entity957 coexisting in the esophagus. However, all of these are cases of synchronous or metachronous development of @entity6962 after chemoradiotherapy in @entity1 of @entity1721 . A 53-year-old @entity1 underwent esophagogas-troduodenoscopy because of @entity662 for several months. Endoscopic examination revealed a huge pedunculated esophageal polypoid mass. Endoscopic submucosal dissection (ESD) was performed and histopathologic examination confirmed @entity189 ( @entity6962 ). He refused additional esophagectomy. After 21 months, third follow-up endoscopy showed poorly-demarcated flat, faint discolored lesions at different location from the previous ESD site and endoscopic biopsies confirmed @entity957 . To the best of our knowledge, this is the first case of metachronous development of @entity1721 in a @entity1 with @entity2910 . (Korean J Gastroenterol 2014;64:364-369).

title: A case of metachronous development of @entity1721 in the @entity1 with XXXX .

answer: @entity2910 :: (MESH:D004941,Disease) :: ['esophageal carcinosarcoma']


abstract: @entity2910 is a rare @entity5 consisting of both @entity3909 , with an incidence of 0.5%. There have been only a few case reports of @entity6962 and @entity957 coexisting in the esophagus. However, all of these are cases of synchronous or metachronous development of @entity6962 after chemoradiotherapy in @entity1 of @entity1721 . A 53-year-old @entity1 underwent esophagogas-troduodenoscopy because of @entity662 for several months. Endoscopic examination revealed a huge pedunculated esophageal polypoid mass. Endoscopic submucosal dissection (ESD) was performed and histopathologic examination confirmed @entity189 ( @entity6962 ). He refused additional esophagectomy. After 21 months, third follow-up endoscopy showed poorly-demarcated flat, faint discolored lesions at different location from the previous ESD site and endoscopic biopsies confirmed @entity957 . To the best of our knowledge, this is the first case of metachronous development of @entity1721 in a @entity1 with @entity2910 . (Korean J Gastroenterol 2014;64:364-369).

title: A case of metachronous development of @entity1721 in the XXXX with @entity2910 .

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: OBJECTIVE: To explore the diagnostic value of single-source dual-energy spectral CT (sDECT) imaging in an @entity5327 (SMAE) @entity235 model. METHODS: Pre-contrast and double-phase contrast-enhanced sDECT were performed before and after embolization in eight SMAE @entity235 models. Monochromatic images of embolized intestine with the best contrast-to-noise ratio (CNR) were obtained and compared with the polychromatic images. CT parameters including attenuation value, @entity1496 content, water content and thickness of the embolized intestinal segments were obtained, and normalized difference in @entity1496 concentration (NDIC) was calculated. RESULTS: The CNR in pre-contrast, arterial phase and portal venous phase at 4   h after embolization was 1.11        1.23, 13.50        1.54 and 10.63        3.75, respectively, significantly higher than those of the polychromatic images (p   <   0.05). The @entity1496 -based images clearly revealed the embolized intestinal segments, which were highly consistent with the gross findings. The difference in attenuation values between the embolization area and non-embolization area in the monochromatic images was 105.06        35.35   HU, higher than that in the polychromatic images (p   <   0.001). The attenuation values and NDIC were significantly decreased at 2   h after embolization, relatively increased at 4   h and gradually decreased at 6 and 8   h. The changing pattern of thickness was similar to that of NDIC over time after embolization. CONCLUSION: sDECT can provide the optimal monochromatic images and allow increased detection rates of lesions. sDECT is a very promising tool for quantitative diagnosis of SMAE. ADVANCES IN KNOWLEDGE: Our research provides more quantitative parameters for the assessment of SMAE by sDECT.

title: Imaging of XXXX using spectral CT in a @entity235 model.

entities_list: @entity5327 :: ('MESH:D065666', 'Disease') :: ['acute superior mesenteric artery embolus']

answer: @entity5327 :: (MESH:D065666,Disease) :: ['acute superior mesenteric artery embolus']


abstract: OBJECTIVE: To explore the diagnostic value of single-source dual-energy spectral CT (sDECT) imaging in an @entity5327 (SMAE) @entity235 model. METHODS: Pre-contrast and double-phase contrast-enhanced sDECT were performed before and after embolization in eight SMAE @entity235 models. Monochromatic images of embolized intestine with the best contrast-to-noise ratio (CNR) were obtained and compared with the polychromatic images. CT parameters including attenuation value, @entity1496 content, water content and thickness of the embolized intestinal segments were obtained, and normalized difference in @entity1496 concentration (NDIC) was calculated. RESULTS: The CNR in pre-contrast, arterial phase and portal venous phase at 4   h after embolization was 1.11        1.23, 13.50        1.54 and 10.63        3.75, respectively, significantly higher than those of the polychromatic images (p   <   0.05). The @entity1496 -based images clearly revealed the embolized intestinal segments, which were highly consistent with the gross findings. The difference in attenuation values between the embolization area and non-embolization area in the monochromatic images was 105.06        35.35   HU, higher than that in the polychromatic images (p   <   0.001). The attenuation values and NDIC were significantly decreased at 2   h after embolization, relatively increased at 4   h and gradually decreased at 6 and 8   h. The changing pattern of thickness was similar to that of NDIC over time after embolization. CONCLUSION: sDECT can provide the optimal monochromatic images and allow increased detection rates of lesions. sDECT is a very promising tool for quantitative diagnosis of SMAE. ADVANCES IN KNOWLEDGE: Our research provides more quantitative parameters for the assessment of SMAE by sDECT.

title: Imaging of @entity5327 using spectral CT in a XXXX model.

answer: @entity235 :: (9615,Species) :: ['canine']


abstract: Six @entity1 who had been operated upon for @entity1498 with patch grafting between 1958 and 1960 were followed for a minimum of 17 years. One of these @entity1 received an aortic homograft patch for an @entity1661 and was in excellent health 21 years later. An aortogram showed no @entity439 formation. One other @entity1 was reoperated upon 1 month after the primary operation because of a @entity2849 . The remaining four @entity1 received either a Dacron graft (three @entity1 ) or an Orlon graft (one @entity1 ), and they all developed an @entity439 in the aortic wall opposite the patch graft. Three of these @entity1 successfully reoperated upon, but the fourth @entity1 died 17 years after patch grafting because of rupture of the @entity439 . Microscopy (in three @entity1 ) showed varying degrees of degenerative changes in the aortic wall opposite the patch. There was no evidence of @entity281 or foreign body reaction in these parts of the aortic walls. The @entity439 develop after patch grafting probably is that part of the circumference is replaced by a material with tensile characteristics differing from those of the aorta itself. Repair of @entity1498 with synthetic patches therefore cannot be recommended.

title: Long-term results after repair of XXXX by patch grafting.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal coarctation']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1498 :: ('MESH:D001017', 'Disease') :: ['coarctation of the aorta', 'aortic coarctations']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['reason aneurysms', 'aneurysm']

entities_list: @entity2849 :: ('MESH:D017541', 'Disease') :: ['pseudoaneurysm']

answer: @entity1498 :: (MESH:D001017,Disease) :: ['coarctation of the aorta']


abstract: Asymptomatic bacterial colonization of @entity65 ( @entity65 ) is widespread and increases the risk of clinical @entity281 . The aim of the study was to evaluate the incidence of bacterial colonization of generator pockets in @entity1 without signs of @entity281 and to analyze the relationship with @entity922 and risk factors. From June 2011 to December 2012, 78 @entity1 underwent CIED replacement or upgrade. Exclusion criteria included a clinical diagnosis of @entity281 , @entity2259 , or @entity884 . All @entity1 were examined for evidence of bacterial 16S rDNA on the device and in the surrounding tissues. Infection cases were recorded during follow-up. The bacterial-positive rate was 38.5% (30 cases); the coagulase-negative @entity794 detection rate was the highest (9 cases, 11.5%). Positive bacterial DNA results were obtained from pocket tissue in 23.1% of @entity1 (18 cases), and bacterial DNA was detected on the device in 29.5% of @entity1 (23 cases). During follow-up (median 24.6 months), two @entity1 (6.7%, 2/30) became symptomatic with the same species of microorganism, @entity794 and @entity5938 . Multivariable logistic regression analysis found that the history of @entity2348 , use of antibiotics, application of antiplatelet drugs, replacement frequency, and @entity177 were independent risk factors for asymptomatic bacterial colonization.

title: Genetic identification and risk factor analysis of asymptomatic bacterial colonization on XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5938 :: ('1282', 'Species') :: ['S. epidermidis']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus', 'S. aureus']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infection']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal insufficiency']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['CIED infection', 'infection']

entities_list: @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular implantable electronic devices', 'CIEDs']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['clinical infection']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['infective endocarditis']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular implantable electronic devices']


abstract: Objectives. To evaluate the application of Disease Activity Score 28 (DAS28) to assess joint involvement in @entity1252 ( @entity1252 ). Methods. Sixty-nine @entity1252 @entity1 , complaining of joint symptoms, and 44 @entity309 ( @entity309 ) @entity1 were enrolled. In @entity1252 @entity1 disease activity was assessed with SLEDAI-2K. DAS28 was calculated in all the @entity1 . Results. Thirty @entity1252 @entity1 (43.5%) showed clinical signs of @entity625 . Mean DAS28 was 4.0    1.4, 22 @entity1 (31.9%) had low disease activity, 29 (42.0%) moderate, and 18 (26.1%) high. We dichotomized @entity1252 @entity1 according to the presence (Group 1) or absence (Group 2) of articular involvement according to SLEDAI-2K: 56.3% of the @entity1 of the second group had a moderate/high activity according to DAS28. We compared @entity1252 @entity1 with 44 @entity309 @entity1 (M/F 9/35, mean age 55.6    14.5 years; mean disease duration 140.4    105.6 months). No significant differences were found regarding the values of DAS28 between @entity1252 and @entity309 @entity1 . On the contrary, the values of tender and swollen joint count were significantly higher in @entity309 compared to @entity1252 @entity1 (P = 0.0002 and P = 0.0001, resp.). Conclusions. We suggest the use of the DAS28 in the assessment of joint involvement in @entity1252 @entity1 .

title: The role of disease activity score 28 in the evaluation of articular involvement in XXXX .

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'Systemic Lupus Erythematosus']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematosus']


abstract: OBJECTIVES: To obtain maxillary anterior tooth dimension and proportion values for the Central Chinese population and to evaluate the existence of sexual dimorphism, any consistent relationships between the tooth ratios, and the presence of golden proportions. METHODS: Tooth dimensions and proportions of six @entity1347 were recorded on gypsum casts obtained from 147 subjects (82 @entity1 and 65 @entity1 ). Of these, 115 casts were digitally photographed in a standardised manner and apparent width values for six @entity1347 were recorded for golden proportion analysis. Existence of sexual dimorphism, any consistent width/height ratio and golden proportions were statistically analysed. One-sample t-test, two-sample t-test, and paired t-test were used to analyse the data. RESULTS: There were no significant differences between measurements on the right and left side. Sexual dimorphism existed for various tooth dimensions. There was no statistically significant difference for width/height ratios between the two genders for central incisor and lateral incisor. However, @entity235 showed a statistically significant difference. The golden proportion guideline was not applicable for this population. CONCLUSION: The @entity1347 dimensions were significantly greater for @entity1 than @entity1 ; however, the mean difference was small (< 0.2 mm) and may not be clinically significant. The golden proportion, or any recurring @entity1347 proportions, was not found for the population. There was a significant difference in width/height ratio of @entity235 between the genders, confirming its greatest gender-based morphological difference.

title: XXXX and proportions in a central mainland chinese population.

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['anterior teeth', 'maxillary anterior teeth']

answer: @entity1347 :: (MESH:C537775,Disease) :: ['Maxillary anterior teeth dimensions']


abstract: Incidence and distribution of lymph node @entity3 were examined in 100 gastrectomy specimens with 104 primary @entity356 . Special emphasis was placed on the correlation with the location of the @entity5 and its size as well as the depth of infiltration and the @entity5 histology. @entity189 with a diameter of up to 6 cm had lymph node @entity3 while this was the case in 83% of larger @entity5 . Infiltration of the muscularis propria only was associated with a 23% incidence of lymphogeneous @entity3 . This figure rose to 75% if the @entity5 reached the subserosa. @entity189 of the diffuse (Lauren) or infiltrating (Ming) type show @entity3 more frequently (83% and 81% respectively) than those of the intestinal or expansive type (58%). In addition, several regions of lymphatic drainage are more frequently involved with the diffuse type. In only 2 @entity1 (2% of all @entity1 or 3% of the @entity1 with lymphogeneous @entity3 ) skipping of lymph nodes could be observed. In all other @entity1 distant lymph nodes showed @entity3 only if the perigastric nodes next to the @entity5 were involved also. These findings support a differentiated, stage- and histology-dependent surgery.

title: [Typical and non-typical lymphogenic spread of XXXX (author's transl)].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Carcinomas', 'Sixty-one percent of carcinomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinomas']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: Oral @entity320 is uncommon, comprising less than 1% of all @entity320 . Consequently, few cases have been reported from any one institution. We report 10 cases of @entity320 seen at the Mayo Clinic between 1905 and 1979. The site of the @entity5 was the hard palate in 4 @entity1 , the soft palate in 2 @entity1 , the lower alveolus in 2 @entity1 , and the upper alveolus and the retromolar trigone in 1 @entity1 each. Eight of these @entity5 occurred in @entity1 , and 8 @entity1 were older than 60 years of age. Presenting symptoms were a pigmented mass in 9 @entity1 , @entity158 in 5 @entity1 , and @entity548 in 3 @entity1 . In 4 @entity1 , the @entity5 occurred in an area of preexisting @entity2117 . The treatment of choice in this disease is surgery; it is the only form of therapy with curative potential. Radiation therapy produced @entity5 regression in one @entity1 in whom the @entity5 was considered inoperable, although there was no effect on eventual survival. Chemotherapy was ineffective in producing @entity5 regression. The prognosis of @entity1 who have @entity320 is dismal; the median survival time in this series was 16 months after diagnosis. Early diagnosis of @entity66 in the mouth and adequate @entity5 resection may improve the prognosis in this disease; however, once the @entity5 recurs, there is essentially no possibility of prolonged survival.

title: XXXX of the oral cavity: review of 10 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['pigmented lesions']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumor', 'tumors']

entities_list: @entity2117 :: ('MESH:D017495', 'Disease') :: ['hyperpigmentation']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['malignant melanoma of the oral cavity', 'malignant melanomas', 'malignant melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['Malignant melanoma']


abstract: OBJECTIVE: @entity1 with inflammatory @entity627 have an increased risk of developing @entity453 . However, outcomes of surgical revascularization in these @entity1 have been rarely studied. We aimed to determine whether, or which, inflammatory @entity627 may pose effects on mortality and adverse cardiac outcomes after coronary artery bypass grafting. METHODS: By using the National Health Insurance Research Database of Taiwan, we identified 40,639 adult @entity1 who underwent first-time coronary artery bypass grafting between 2000 and 2010. Among these @entity1 , 101 had @entity309 , 56 had @entity1252 , and 73 had @entity1691 . The odds ratios (ORs) of operative mortality and hazard ratios (HRs) of overall mortality and adverse cardiac outcomes after coronary artery bypass grafting (ie, @entity583 and repeat revascularization) in relation to @entity309 , @entity1252 , and @entity1691 were estimated. RESULTS: With adjustment for potential confounders including @entity1 characteristics, hospital levels, and combined surgery, @entity1252 was an independent predictor for operative mortality (adjusted OR, 2.63; 95% confidence interval [CI], 1.04-6.65; P  =  .04) and @entity1691 was marginally associated with operative mortality (adjusted OR, 2.41; 95% CI, 0.99-5.88; P  =  .054). @entity1252 was a significantly independent predictor for overall mortality during the follow-up period (adjusted HR, 2.23; 95% CI, 1.51-3.31; P  <  .0001) and might increase the risk of repeat revascularization (adjusted HR, 1.89; 95% CI, 0.97-3.68; P  =  .06). Neither @entity309 nor @entity1691 was significantly associated with overall mortality and adverse cardiac outcomes. CONCLUSIONS: Our study may help surgeons and physicians recognize the potential risks inherent to @entity1252 and @entity1691 when conducting coronary artery bypass grafting and providing follow-up care.

title: Outcomes of coronary artery bypass grafting in @entity1 with inflammatory XXXX : An 11-year nationwide cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity627 :: ('MESH:D012216', 'Disease') :: ['rheumatic diseases']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['systemic lupus erythematosus', 'Systemic lupus erythematosus']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['ankylosing spondylitis']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary atherosclerosis']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

answer: @entity627 :: (MESH:D012216,Disease) :: ['rheumatic diseases']


abstract: OBJECTIVE: @entity1 with inflammatory @entity627 have an increased risk of developing @entity453 . However, outcomes of surgical revascularization in these @entity1 have been rarely studied. We aimed to determine whether, or which, inflammatory @entity627 may pose effects on mortality and adverse cardiac outcomes after coronary artery bypass grafting. METHODS: By using the National Health Insurance Research Database of Taiwan, we identified 40,639 adult @entity1 who underwent first-time coronary artery bypass grafting between 2000 and 2010. Among these @entity1 , 101 had @entity309 , 56 had @entity1252 , and 73 had @entity1691 . The odds ratios (ORs) of operative mortality and hazard ratios (HRs) of overall mortality and adverse cardiac outcomes after coronary artery bypass grafting (ie, @entity583 and repeat revascularization) in relation to @entity309 , @entity1252 , and @entity1691 were estimated. RESULTS: With adjustment for potential confounders including @entity1 characteristics, hospital levels, and combined surgery, @entity1252 was an independent predictor for operative mortality (adjusted OR, 2.63; 95% confidence interval [CI], 1.04-6.65; P  =  .04) and @entity1691 was marginally associated with operative mortality (adjusted OR, 2.41; 95% CI, 0.99-5.88; P  =  .054). @entity1252 was a significantly independent predictor for overall mortality during the follow-up period (adjusted HR, 2.23; 95% CI, 1.51-3.31; P  <  .0001) and might increase the risk of repeat revascularization (adjusted HR, 1.89; 95% CI, 0.97-3.68; P  =  .06). Neither @entity309 nor @entity1691 was significantly associated with overall mortality and adverse cardiac outcomes. CONCLUSIONS: Our study may help surgeons and physicians recognize the potential risks inherent to @entity1252 and @entity1691 when conducting coronary artery bypass grafting and providing follow-up care.

title: Outcomes of coronary artery bypass grafting in XXXX with inflammatory @entity627 : An 11-year nationwide cohort study.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: Traditional cranioplasty methods focus on pre-operative or intraoperative hand molding. Recently, CT-guided @entity12316 (PEEK) plate reconstruction enables precise, time-saving reconstruction. This case series aims to show a single institution experience with use of PEEK cranioplasty as an effective, safe, precise, reusable, and time-saving cranioplasty technique in large, @entity129 . METHODS: We performed a 6-year retrospective review of cranioplasty procedures performed at our affiliated hospitals using PEEK implants. A total of nineteen @entity1 underwent twenty-two cranioplasty procedures. Pre-operative, intra-operative, and post-operative data was collected. RESULTS: Nineteen @entity1 underwent twenty-two procedures. Time interval from injury to loss of primary cranioplasty averaged 57.7 months (0-336  mo); 4.0 months (n  =  10, range 0-19) in cases of @entity130 . Time interval from primary cranioplasty loss to PEEK cranioplasty was 11.8 months for @entity281 (n  =  11, range 6-25  mo), 12.2 months for @entity130 (n  =  5, range 2-27  mo), and 0.3 months for cosmetic or functional reconstructions (n  =  3, range 0-1). Similar surgical techniques were used in all @entity1 . Drains were placed in 11/22 procedures. Varying techniques were used in skin closure, including adjacent tissue transfer (4/22) and free tissue transfer (1/22). The PEEK plate required modification in four procedures. Three @entity1 had reoperation following PEEK plate reconstruction. CONCLUSION: Cranioplasty utilizing CT-guided PEEK plate allows easy inset, anatomic accuracy, mirror image aesthetics, simplification of complex 3D defects, and potential time savings. Additionally, it's easily manipulated in the operating room, and can be easily re-utilized in cases of intraoperative course changes or @entity281 .

title: Computed-tomography modeled XXXX ( @entity12316 ) implants in revision cranioplasty.

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['complex cranial defects']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity12316 :: ('MESH:C063834', 'Chemical') :: ['polyether ether ketone']

answer: @entity12316 :: (MESH:C063834,Chemical) :: ['polyether ether ketone']


abstract: PURPOSE: Traditional cranioplasty methods focus on pre-operative or intraoperative hand molding. Recently, CT-guided @entity12316 (PEEK) plate reconstruction enables precise, time-saving reconstruction. This case series aims to show a single institution experience with use of PEEK cranioplasty as an effective, safe, precise, reusable, and time-saving cranioplasty technique in large, @entity129 . METHODS: We performed a 6-year retrospective review of cranioplasty procedures performed at our affiliated hospitals using PEEK implants. A total of nineteen @entity1 underwent twenty-two cranioplasty procedures. Pre-operative, intra-operative, and post-operative data was collected. RESULTS: Nineteen @entity1 underwent twenty-two procedures. Time interval from injury to loss of primary cranioplasty averaged 57.7 months (0-336  mo); 4.0 months (n  =  10, range 0-19) in cases of @entity130 . Time interval from primary cranioplasty loss to PEEK cranioplasty was 11.8 months for @entity281 (n  =  11, range 6-25  mo), 12.2 months for @entity130 (n  =  5, range 2-27  mo), and 0.3 months for cosmetic or functional reconstructions (n  =  3, range 0-1). Similar surgical techniques were used in all @entity1 . Drains were placed in 11/22 procedures. Varying techniques were used in skin closure, including adjacent tissue transfer (4/22) and free tissue transfer (1/22). The PEEK plate required modification in four procedures. Three @entity1 had reoperation following PEEK plate reconstruction. CONCLUSION: Cranioplasty utilizing CT-guided PEEK plate allows easy inset, anatomic accuracy, mirror image aesthetics, simplification of complex 3D defects, and potential time savings. Additionally, it's easily manipulated in the operating room, and can be easily re-utilized in cases of intraoperative course changes or @entity281 .

title: Computed-tomography modeled @entity12316 ( XXXX ) implants in revision cranioplasty.

answer: @entity12316 :: (MESH:C063834,Chemical) :: ['PEEK']


abstract: UNASSIGNED: Abstract Tumor @entity3 is the biggest challenge in @entity5 therapy. During the @entity3 process, metastatic cells could acquire stealth ability toward immune system through the formation of a protection cloak by hijacking platelets (PTs). Heparins, a heterogeneous mixture of glycosaminoglycans, can inhibit metastatic cascades by blocking P-selectin-mediated intercellular adhesion between @entity5 cells and PTs. In this study, low-molecular-weight heparin-coated doxorubicin-loaded liposome (LMWH-DOX-Lip) was developed for @entity3 preventative therapy. The formation of LMWH-DOX-Lip was based on electrostatic interactions between the negatively charged heparins and cationic lipids. LMWH-DOX-Lip prepared at the optimum prescription possessed high entrapment efficiency, ideal particle size and zeta potential. Morphology of LMWH-DOX-Lip was characterized by atomic force microscopy and transmission electron microscopy. The results of confocal microscopic observations and flow cytometry analysis indicated that LMWH-DOX-Lip mediated an efficient cellular uptake in @entity19 @entity320 cell line. Besides, LMWH-DOX-Lip displayed an increased cytotoxic over their unmodified counterparts. Furthermore, the inhibition effect of LMWH-DOX-Lip on adhesion between @entity5 cells and PTs/P-selectin was observed. In vivo study performed on a @entity320 @entity19 model revealed a substantially @entity5 @entity3 prevention by LMWH-DOX-Lip. All these results suggested that LMWH-DOX-Lip could significantly inhibit @entity3 through preventing the @entity5 cell-platelet interactions and in the meantime suppressed @entity5 growth.

title: A low-molecular-weight heparin-coated doxorubicin-liposome for the prevention of XXXX @entity3 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'pulmonary melanoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity320 :: (MESH:D008545,Disease) :: ['melanoma']


abstract: UNASSIGNED: Abstract Tumor @entity3 is the biggest challenge in @entity5 therapy. During the @entity3 process, metastatic cells could acquire stealth ability toward immune system through the formation of a protection cloak by hijacking platelets (PTs). Heparins, a heterogeneous mixture of glycosaminoglycans, can inhibit metastatic cascades by blocking P-selectin-mediated intercellular adhesion between @entity5 cells and PTs. In this study, low-molecular-weight heparin-coated doxorubicin-loaded liposome (LMWH-DOX-Lip) was developed for @entity3 preventative therapy. The formation of LMWH-DOX-Lip was based on electrostatic interactions between the negatively charged heparins and cationic lipids. LMWH-DOX-Lip prepared at the optimum prescription possessed high entrapment efficiency, ideal particle size and zeta potential. Morphology of LMWH-DOX-Lip was characterized by atomic force microscopy and transmission electron microscopy. The results of confocal microscopic observations and flow cytometry analysis indicated that LMWH-DOX-Lip mediated an efficient cellular uptake in @entity19 @entity320 cell line. Besides, LMWH-DOX-Lip displayed an increased cytotoxic over their unmodified counterparts. Furthermore, the inhibition effect of LMWH-DOX-Lip on adhesion between @entity5 cells and PTs/P-selectin was observed. In vivo study performed on a @entity320 @entity19 model revealed a substantially @entity5 @entity3 prevention by LMWH-DOX-Lip. All these results suggested that LMWH-DOX-Lip could significantly inhibit @entity3 through preventing the @entity5 cell-platelet interactions and in the meantime suppressed @entity5 growth.

title: A low-molecular-weight heparin-coated doxorubicin-liposome for the prevention of @entity320 XXXX .

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: INTRODUCTION: Cigarette smoking is common among adults with @entity1118 . The primary objective of this study was to determine the period prevalence of smoking in @entity1 with @entity1118 . A secondary objective was to determine the prevalence of smoking among @entity1 with commonly occurring @entity158 diagnoses including @entity239 , @entity1643 , and @entity10 . METHODS: This population study included 5350 @entity1 (1256 smokers, 4094 nonsmokers) admitted to the Mayo @entity158 Rehabilitation Center from January 1998 through December 2012. Smoking status was determined using a self-report questionnaire. RESULTS: During the 15  year study period, the overall prevalence of smoking was 23.5  % (95  % CI 22.4 - 24.6). The prevalence of smoking in 2000, 2005, and 2010 was 24.2, 25.7, and 28.3  % respectively. The overall prevalence of smoking in @entity1 with @entity239 , @entity1643 , and @entity10 was 25.2  % (95  % CI 22.8 - 28.3), 22.8  % (95  % CI 21.3 - 25.9), and 21.2  % (95  % CI 17.9 - 24.7), respectively. In a multiple variable logistic model adjusted for age and sex, opioid use was significantly associated with status as a current smoker. CONCLUSION: The prevalence of smoking in @entity1 with @entity1118 has not declined when compared to the general population. The higher prevalence of smoking was consistently observed in commonly occurring @entity158 diagnoses including @entity239 , @entity615 , and @entity10 . Further research is needed to identify the potential factors that contribute to the high prevalence of smoking in this @entity1 population.

title: Prevalence of smoking in adults with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['back pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'Comprehensive Pain']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity1118 :: (MESH:D059350,Disease) :: ['chronic pain']


abstract: INTRODUCTION: Many studies have clearly linked exposure to @entity13414 ( @entity13414 ) to various somatic diseases, however, few studies have examined the relationship between @entity13414 and @entity146 and those that have were only conducted with specific groups. The purpose of this study was to examine the association between @entity13414 exposure and @entity146 among Chinese residents in both worksites and public places. METHODS: A cross-sectional multistage sampling design was used to interview subjects from 21 selected cities in China. Using a standardized questionnaire including demographic characteristics, @entity13414 exposure, and mental health information was collected. Multiple logistic regression analysis was used to assess the association between @entity13414 exposure and @entity146 . RESULTS: Sixteen-thousand-eight-hundred-sixty-six valid questionnaires were collected and utilized in this study. Of 11,206 non-smokers, @entity13414 exposure prevalence in workplaces and public places were respectively 78.4  % (95  % C.I.:74.3-82.5  %) and 80.7  % (95  % C.I.:74.6-86.5  %). Multiple logistic regressions showed @entity13414 exposures in these venues were positively related to @entity146 . CONCLUSIONS: These findings further support the health hazards of @entity13414 exposure. Findings underscore the importance of controlling @entity13414 exposure, and can be used to inform future @entity13414 control policies and reinforce the need for public education in China.

title: Second hand smoke exposure in public venues and XXXX : a representative nationwide study of China.

entities_list: @entity13414 :: ('MESH:C536784', 'Disease') :: ['Second Hand Smoke', 'SHS']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders', 'mental disorder']

answer: @entity146 :: (MESH:D001523,Disease) :: ['mental disorder']


abstract: Antrodia camphorata is a rare Taiwanese medicinal mushroom. Antrodia camphorata extract has been reported to exhibit antioxidant, anti- @entity32 , antimetastasis, and anticancer activities and plays a role in liver @entity82 , vasorelaxation, and immunomodulation. @entity32 leads to @entity455 and @entity65 , including @entity1028 , @entity101 , and @entity731 . Platelet activation plays a crucial role in intravascular @entity715 , which is involved in a wide variety of @entity65 . However, the effect of Antrodia camphorata on platelet activation remains unclear. We examined the effects of Antrodia camphorata on platelet activation. In the present study, Antrodia camphorata treatment (56-224    g/mL) inhibited @entity1423 induced by collagen, but not @entity2872 , an analogue of @entity2404 , thrombin, and @entity1426 . Antrodia camphorata inhibited collagen-induced @entity460 ( @entity141 ) mobilization and phosphorylation of @entity7131 ( @entity7131 ) and @entity584 . In addition, Antrodia camphorata significantly reduced the aggregation and phosphorylation of @entity7131 in @entity10670 ( @entity10671 ) activated platelets. In conclusion, Antrodia camphorata may inhibit platelet activation by inhibiting of @entity141 and @entity7131 cascade and the @entity584 pathway. Our study suggests that Antrodia camphorata may be a potential therapeutic agent for preventing or treating @entity1031 .

title: Effect of Antrodia camphorata on Inflammatory Arterial XXXX -Mediated Platelet Activation: The Pivotal Role of Protein Kinase C.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation', 'Critical vascular inflammation']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity2404 :: ('MESH:D013928', 'Chemical') :: ['thromboxane A2']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity7131 :: ('MESH:D020151', 'Disease') :: ['PKC', 'protein kinase C']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity10670 :: ('MESH:D015240', 'Chemical') :: ['phorbol-12, 13-dibutyrate']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic disorders']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysms']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

answer: @entity715 :: (MESH:D013927,Disease) :: ['Thrombosis']


abstract: UNASSIGNED: Thermal ablation is a minimally invasive @entity5 treatment which has been rapidly gaining clinical acceptance. It is well known that thermal ablation increases the acoustic attenuation and shear modulus of tissue. In this work, we examine changes to the spatial distribution of scatterers in liver tissue following thermal ablation. Acoustic scatterers within liver tissue have frequently been modeled as pseudo-periodic. The positions of pseudo-periodic scatterers have been Gamma distributed along the beam dimension, and these scatterers are characterized by their @entity3626 ( @entity3626 ). Prior work have demonstrated significant changes in @entity3626 due to diffuse @entity409 , such as @entity1560 progressing to @entity82 . However, relatively few results have been reported regarding changes in @entity3626 following thermal ablation. In this study, we estimated @entity3626 in ex vivo @entity291 liver by detecting local maxima in spectral coherence functions calculated using Thomson's multi-taper method. We examined a large number of uncorrelated regions of interest recorded from five normal @entity291 livers (~300 images from each animal). We also examined a large number of ROI's from five @entity291 livers following thermal coagulation. All @entity291 livers were obtained from a commercial meat production facility immediately following animal sacrifice and imaged within 12 hours. Thermal coagulation was induced by heating liver in saline water baths at 80   C for 45 minutes. For normal, unheated liver an @entity3626 of approximately 1.5 mm was estimated. Following thermal ablation, an @entity3626 of approximately 0.5 mm in thermally coagulated tissue was obtained. Frequently, studies estimating @entity3626 in liver tissue provide an @entity3626 estimate regardless of the state of tissue. Authors rarely present what their @entity3626 estimation algorithm would produce if it were applied to tissue which is better modeled as a collection of uniformly, randomly distributed scatterers lacking periodicity. In this study, we found that thermal coagulation results in a loss of periodicity. The @entity3626 of 0.5 mm corresponds to the value that a spectral coherence-based @entity3626 algorithm would produce if presented with a signal that was generated from uniform, randomly distributed scatterers.

title: Alterations in Ultrasound Scattering Following Thermal Ablation in ex vivo XXXX Liver.

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['steatosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver disease']

entities_list: @entity3626 :: ('MESH:D018489', 'Disease') :: ['mean scatterer spacing', 'MSS']

answer: @entity291 :: (9913,Species) :: ['Bovine']


abstract: The prevalence of @entity65 as a marker of @entity4148 was studied in a group of juvenile @entity6 with long-standing disease, aged 20-58 years (mean 36). No @entity1 had clinical evidence of @entity11460 . The study was carried out employing the most simple techniques and routine equipment. Resting heart rate, beta-to-beat variation, Valsalva ratio, systolic blood pressure in supine position and immediately after standing were measured. The results were compared with those determined in an age and sex-matched population. Beat-to-beat variation test appeared to be the most sensitive technique in detecting an impaired autonomic function (12/54 = 22.2%). Resting @entity591 was found in 10 @entity1 and @entity551 in 6. Only 1 @entity1 had an abnormal Valsalva ratio associated with @entity551 and reduced beta-to-beat variation. In agreement with previous studies our data confirm that @entity5433 is frequent in asymptomatic @entity6 . The methods to detect these abnormalities are easy to perform. Therefore they may be routinely used as screening tests in the @entity6 population.

title: Abnormal cardiovascular reflexes in juvenile @entity6 as preclinical signs of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity4148 :: ('MESH:D001342', 'Disease') :: ['autonomic neuropathy']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['abnormalities of cardiovascular reflexes']

entities_list: @entity5433 :: ('MESH:C563939', 'Disease') :: ['autonomic dysfunction']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['postural hypotension']

entities_list: @entity11460 :: ('MESH:D012791', 'Disease') :: ['autonomic failure']

answer: @entity4148 :: (MESH:D001342,Disease) :: ['autonomic neuropathy']