abstract: UNASSIGNED: @entity33 is a complex inflammatory reaction of the mucous membranes of the alimentary tract upon chemotherapy and radiotherapy treatment in oncology @entity1 . @entity33 can be subdivided in oral and @entity344 ( @entity33 ). The damage to the gastrointestinal tract compromises the intestinal function and thereby the nutritional status and the quality of life, and eventually affects survival. The literature on @entity33 focuses mainly on adults. This review focuses on data available on @entity33 in @entity5 @entity1 . An evaluation of the clinical presentation and consequences of @entity33 in @entity1 is outlined. The review summarizes key issues for clinicians with respect to risk analysis for developing @entity33 and the diagnosis of this condition in @entity1 . Information on these issues is obtained from clinical trials in @entity1 and adults, and from animal models. Diagnostic tools and assessment of severity of @entity33 in @entity1 is elaborated on. Furthermore, the clinical management of the symptoms and consequences of @entity33 in @entity1 , with specific focus on nutritional support, are discussed.

title: Risk analysis, diagnosis and management of @entity344 in XXXX @entity1 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['pediatric cancer']


abstract: UNASSIGNED: @entity33 is a complex inflammatory reaction of the mucous membranes of the alimentary tract upon chemotherapy and radiotherapy treatment in oncology @entity1 . @entity33 can be subdivided in oral and @entity344 ( @entity33 ). The damage to the gastrointestinal tract compromises the intestinal function and thereby the nutritional status and the quality of life, and eventually affects survival. The literature on @entity33 focuses mainly on adults. This review focuses on data available on @entity33 in @entity5 @entity1 . An evaluation of the clinical presentation and consequences of @entity33 in @entity1 is outlined. The review summarizes key issues for clinicians with respect to risk analysis for developing @entity33 and the diagnosis of this condition in @entity1 . Information on these issues is obtained from clinical trials in @entity1 and adults, and from animal models. Diagnostic tools and assessment of severity of @entity33 in @entity1 is elaborated on. Furthermore, the clinical management of the symptoms and consequences of @entity33 in @entity1 , with specific focus on nutritional support, are discussed.

title: Risk analysis, diagnosis and management of @entity344 in @entity5 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['GI mucositis', 'mucositis', 'Mucositis']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal mucositis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['pediatric cancer']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: The aim of this study was to determine the clinical characteristics, molecular epidemiology and biofilm production of @entity3064 clinical isolates obtained from a tertiary-care hospital in Mexico. Clinical isolates of A. baumannii (n=152) isolated from 2007 to 2012 were included. Clonal diversity was analysed by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Antimicrobial susceptibility was determined using the broth microdilution method. IMP, VIM, NDM and OXA-type genes were screened by PCR. Biofilm production was analysed using the crystal violet method. Mortality attributable to A. baumannii @entity281 was 14.5%. Fifty-four clones were detected, of which five predominated. MLST results showed three new sequence types and two reported sequence types. More than 86% of the isolates were resistant to @entity2177 , @entity5505 and @entity3524 . Furthermore, 50.7% and 35.5% of the isolates were resistant to @entity2892 and @entity2889 , respectively. Of the isolates evaluated, 28.3% and 25.7% were positive for the @entity18717 and @entity46246 genes, respectively. Biofilm production was associated with resistance to @entity2892 (P=0.002).

title: Genetic characterisation of drug resistance and clonal dynamics of XXXX in a hospital setting in Mexico.

entities_list: @entity2892 :: ('MESH:D015378', 'Chemical') :: ['imipenem']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity2889 :: ('MESH:C059500', 'Chemical') :: ['meropenem']

entities_list: @entity3524 :: ('MESH:D002439', 'Chemical') :: ['cefotaxime']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity3064 :: ('470', 'Species') :: ['Acinetobacter baumannii']

entities_list: @entity5505 :: ('MESH:D002442', 'Chemical') :: ['ceftazidime']

answer: @entity3064 :: (470,Species) :: ['Acinetobacter baumannii']


abstract: BACKGROUND: There is scarce information about @entity1142 in elderly subjects. Among the variety of factors causing @entity1142 , the sleeping hours are a factor usually not taken into account. OBJECTIVES: To determine the association between hours of sleep during the week and weekend, with @entity1142 in older adults. DESIGN: Sleep quality, stool consistency, physical activity (PA) and dietary fiber intake was assessed using various validated surveys in 424 healthy autonomous elderly @entity1 and @entity1 , living in Santiago, Chile. RESULTS: Half of the @entity1 reported having abnormal stools ( @entity1142 and @entity294 ). Subjects who had @entity1142 had lower PA and greater @entity998 than subjects with normal bowel movements. The elderly @entity1 with @entity1142 had a higher amount of sleep during the week and weekend, that subjects with normal bowel movements (9.4    1.6 vs 8.8    1.8 hours, p = 0.013). The constipated subjects slept significantly more than those with normal evacuation (9.7    1.5 vs 9.2    1.8, p = 0.024). No differences in the nutritional status and fiber intake among @entity1 with different consistencies were found. CONCLUSIONS: There is an association between sleep and the consistency of the stools in elderly @entity1 . It would be interesting to evaluate whether long-term improvement of these factors could have a positive impact on the other.

title: [Relationship between sleep and XXXX in the elderly chileans].

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'men']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity998 :: ('MESH:D002303', 'Disease') :: ['difficulty falling asleep']

answer: @entity1142 :: (MESH:D003248,Disease) :: ['constipation']


abstract: UNASSIGNED: Traditional Chinese medicine (TCM) is a theoretical based system and is completely different from western medicine and states that @entity66 , especially @entity102 , are cured or relieved. "Zheng" (syndrome) is a summarization of the pathological changes which take place during the different stages of the development of a disease, including its location, cause and nature as well as the state of both Xie-qi (pathogenic factors) and Zheng-qi (healthy energy). Compared to a single symptom, syndrome can demonstrate the nature of a disease more extensively, completely and correctly. However, it is difficult to compare "Zheng" to the western medicine theory, which is based on scientific evidence for the diagnosis and treatment of a specific disease. @entity172 de   ciency is a major pathogenetic factor in @entity604 after menopause and oophorectomy with the subsequent risk of developing @entity170 . According to TCM theory, the kidney stores essence and this can transform into bone marrow to nourish the bones, strenghthen the skeleton by promoting growth and repair. The kidney de   ciency can decrease the @entity172 level adjusted by the @entity444 , causing @entity170 . Traditional Chinese medicines tonifying the kidney can significantly enhance the level of @entity172 to alleviate @entity170 . In combination with other evidence, we further deduce that the syndrome as defined within TCM has a similar pathological mechanism to that defined by western medicine. If TCM theory is to be understood and accepted, and further fused with the western medicine theory, the micro pathological basis of @entity1058 must be investigated extensively, which will lead to bridging the two theories together. The fusion of TCM with western medicine will pay more attention to analyzing the common nature and difference of @entity66 . This paper reviews the way forward for new translational advances.

title: Mechanism of treatment of kidney deficiency and XXXX is similar by Traditional Chinese Medicine.

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'Estrogen']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['disease and syndrome', 'numerous diseases']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases']

entities_list: @entity1058 :: ('MESH:C562377', 'Disease') :: ['TCM syndrome']

entities_list: @entity444 :: ('MESH:D006059', 'Disease') :: ['gonadal axis']

answer: @entity170 :: (MESH:D010024,Disease) :: ['osteoporosis']


abstract: OBJECTIVE: To explore the differences in volume and localization of the internal gross target volume and planning target volume delineated by clips and/or @entity2080 based on four-dimensional computed tomography (4D-CT) during free-breathing in @entity0 @entity1 after breast conserving surgery. METHODS: Fifteen @entity0 @entity1 after breast-conserving surgery (BCS) were recruited for external-beam partial breast irradiation (EB-PBI). On the ten sets CT images, the gross @entity5 volumes (GTV) formed by the clips, the @entity2080 , and both the clips and @entity2080 were delineated and defined as GTVc, GTVs and GTVc+s, respectively. Ten GTVc, GTVs and GTVc+s on the ten sets CT images produced the IGTVc, IGTVs, IGTVc+s. The PTVc, PTVs, PTVc+s were created by adding 15 mm to the IGTVc, IGTVs, IGTVc+s, respectively. The IGTV and @entity343 volume and distance between the centers of IGTVc, IGTVs, IGTVc+s and PTVc, PTVs, PTVc+s were all recorded. Conformity index (CI) and degree of inclusion (DI) were calculated for IGTV/IGTV and @entity343 / @entity343 , respectively. RESULTS: The volume of IGTVc+s[(35.73    19.77) cm(3)] was significantly larger than the IGTVc [(28.35    17.54) cm(3)] and IGTVs [(24.19    21.53) cm(3)] (P < 0.05), and the volume of PTVc+s [(191.59    69.74) cm(3)] was significantly larger than that of the PTVc [(161.53    61.07) cm(3)] and PTVs [(148.98    62.22)cm(3)] (P < 0.05). There were significant differences between the DIs of IGTVc in IGTVc+s and IGTVc+s in IGTVc, the DIs of IGTVs in IGTVc+s and IGTVc+s in IGTVs, the DIs of PTVc in PTVc+s and PTVc+s in PTVc, and the DIs of PTVs vs. PTVc+s and PTVc+s in PTVs (P < 0.05 for all). The CI of IGTVc/IGTVc+s (0.63    0.14) and the CI of IGTVs/IGTVc+s (0.54    0.17) were significant larger than that of the CI of IGTVc/IGTVs (0.40    0.14)(P < 0.05). There were non-significant differences among the CI of PTVc/PTVs, PTVc/PTVc+s and PTVs/PTVc+s (0.73    0.12, 0.78    0.13 vs. 0.75    0.17). The DIs and CIs of IGTV/IGTV and @entity343 / @entity343 were negatively correlated with their centroid distance (P < 0.05). CONCLUSIONS: There are volume difference and spatial mismatch between the target volumes delineated on the basis of surgical clips and @entity2080 . The DI and CI between the PTVs are larger than that between the IGTV. External-beam partial breast irradiation should be implemented based on the @entity343 that is defined based on both @entity2080 .

title: [Comparison of the volume and localization of internal gross target volume and planning target volume delineated by clips and XXXX based on 4D-CT scan for external-beam partial breast irradiation after breast conserving surgery].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity2080 :: ('MESH:D049291', 'Disease') :: ['seroma', 'seroma and surgical clips']

answer: @entity2080 :: (MESH:D049291,Disease) :: ['seroma']


abstract: UNASSIGNED: Purpose To compare the long-term outcomes of repeated hepatic resection and radiofrequency (RF) ablation for recurrent @entity157 ( @entity157 ) by using propensity score matching. Materials and Methods This retrospective study was approved by the institutional review board, and the requirement to obtain informed consent was waived. Thirty-nine @entity1 who underwent repeated hepatic resection and 178 who underwent RF ablation for recurrent @entity157 (mean @entity5 size    standard deviation, 1.8 cm    0.7) between November 1994 and December 2012 were included in the study. @entity1 ranged in age from 24 to 85 years (mean, 54.9 years). @entity1 ranged in age from 25 to 85 years (mean, 54.8 years), and @entity1 ranged in age from 24 to 76 years (mean, 55.4 years). A 1:2 repeated hepatic resection group-RF ablation group matching was done by using propensity score matching. The @entity1349 ( @entity1349 ) and disease-free survival (DFS) were compared before and after propensity score matching. Complications were assessed. Results Before matching, @entity1349 rates at 1, 3, 5, and 8 years were 88.8%, 88.8%, 83.9%, and 56.3%, respectively, with repeated hepatic resection and 98.9%, 82.5%, 71.0%, and 58.3% for RF ablation. DFS rates at 1, 3, and 5 years were 66.1%, 48.5%, and 43.1% for repeated hepatic resection and 70.1%, 40.8%, and 30.0% for RF ablation. After matching, the @entity1349 rates at 1, 3, 5, and 8 years were 98.7%, 85.7%, 72.1%, and 68.6%, respectively, and the DFS rates at 1, 3, and 5 years were 71.8%, 45.1%, and 39.4% in the RF ablation group (n = 78). Neither the @entity1349 nor DFS rate was significantly different between the two groups before matching (P = .686 and P = .461) and after matching (P = .834 and P = .960). The postoperative mortality rate was 2.6% in the repeated hepatic resection group and 0% in the RF ablation group. Conclusion The long-term @entity1349 and DFS were not significantly different between repeated hepatic resection and RF ablation for @entity1 with recurrent @entity157 after hepatic resection.    RSNA, 2015.

title: Repeated Hepatic Resection versus Radiofrequency Ablation for Recurrent XXXX after Hepatic Resection: A Propensity Score Matching Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'Men']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']


abstract: AIM: We used near-infrared spectrophotometry to assess the initial and final abdominal and cerebral saturations during cardiopulmonary resuscitation (CPR) of @entity1 with out-of-hospital @entity1167 to determine if there is a correlation between increase in these saturation values and return of spontaneous circulation. MATERIALS AND METHODS: We evaluated 34 @entity1 with out-of-hospital @entity1167 without witnesses brought to our emergency department. Abdominal and cerebral saturations were measured using near-infrared spectrophotometry from the start of CPR. Cardiopulmonary resuscitation was performed for a maximum of 30 minutes. The effect of abdominal saturations in @entity1 with or without spontaneous circulation restored through CPR was then assessed. RESULTS: Thirty-four @entity1 (17 males + females) with a mean age of 63.06    11.66 years were included in the study. A significant correlation was determined between increase in abdominal saturations measured at the start and end of CPR and the return of spontaneous circulation (P < .001). A good positive correlation was also identified between abdominal saturation and return of spontaneous circulation. CONCLUSION: @entity1 with increased abdominal and cerebral saturation values have a higher survival rate after appropriate CPR. This noninvasive measurement system and monitoring of @entity1 during CPR may be a good method of predicting return of spontaneous circulation and assessing abdominal perfusion.

title: Abdominal oxygen saturation for monitoring return of spontaneous circulation in out-of-hospital XXXX using near infrared spectrophometry.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

answer: @entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']


abstract: BACKGROUND: The efficacy of postoperative radiotherapy (PORT) for thymic @entity5 is still controversial. Using the Japanese Association for Research on the Thymus (JART) database, this study was aimed at clarifying the efficacy of PORT for @entity5 and @entity704 . METHODS: The JART database registered the records of 2835 @entity1 collected from 32 Japanese institutions from 1991 to 2010. @entity704 and @entity704 at stage II or III were extracted. The efficacy of PORT with respect to @entity4557 ( @entity4557 ) and @entity1349 ( @entity1349 ) was evaluated with the Kaplan-Meier method and Cox regression analysis. RESULTS: There were 1265 @entity1 in all: 155 @entity704 cases (12.3%) and 1110 @entity704 cases (87.7%). Eight hundred ninety-five (70.8%) were at stage II, and 370 (29.2%) were at stage III. Four hundred three cases (31.9%) underwent PORT. PORT for @entity5 was associated with increasing @entity4557 (hazard ratio, 0.48; 95% confidence interval, 0.30-0.78; P =   .003) but was not associated with @entity1349 (hazard ratio, 0.94; 95% confidence interval, 0.51-1.75; P =   .536). PORT for @entity34 was not associated with @entity4557 or @entity1349 (P =   .350). A subgroup analysis of stage III @entity704 showed no factor associated with the efficacy of PORT. CONCLUSIONS: In this study, PORT did not increase @entity4557 or @entity1349 for @entity34 but increased @entity4557 for @entity5 .

title: Postoperative radiotherapy is effective for XXXX but not for @entity5 : the Japanese Association for Research on the Thymus Database Study.

entities_list: @entity4557 :: ('MESH:D012008', 'Disease') :: ['RFS', 'relapse-free survival']

entities_list: @entity704 :: ('MESH:D013945', 'Disease') :: ['thymic carcinoma', 'thymoma', 'Thymic carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage II and III thymic carcinoma', 'Masaoka stage II and III thymic carcinoma', 'epithelial tumors']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['stage II and III thymoma', 'stage II or III thymoma']

answer: @entity704 :: (MESH:D013945,Disease) :: ['thymic carcinoma']


abstract: BACKGROUND: The efficacy of postoperative radiotherapy (PORT) for thymic @entity5 is still controversial. Using the Japanese Association for Research on the Thymus (JART) database, this study was aimed at clarifying the efficacy of PORT for @entity5 and @entity704 . METHODS: The JART database registered the records of 2835 @entity1 collected from 32 Japanese institutions from 1991 to 2010. @entity704 and @entity704 at stage II or III were extracted. The efficacy of PORT with respect to @entity4557 ( @entity4557 ) and @entity1349 ( @entity1349 ) was evaluated with the Kaplan-Meier method and Cox regression analysis. RESULTS: There were 1265 @entity1 in all: 155 @entity704 cases (12.3%) and 1110 @entity704 cases (87.7%). Eight hundred ninety-five (70.8%) were at stage II, and 370 (29.2%) were at stage III. Four hundred three cases (31.9%) underwent PORT. PORT for @entity5 was associated with increasing @entity4557 (hazard ratio, 0.48; 95% confidence interval, 0.30-0.78; P =   .003) but was not associated with @entity1349 (hazard ratio, 0.94; 95% confidence interval, 0.51-1.75; P =   .536). PORT for @entity34 was not associated with @entity4557 or @entity1349 (P =   .350). A subgroup analysis of stage III @entity704 showed no factor associated with the efficacy of PORT. CONCLUSIONS: In this study, PORT did not increase @entity4557 or @entity1349 for @entity34 but increased @entity4557 for @entity5 .

title: Postoperative radiotherapy is effective for @entity704 but not for XXXX : the Japanese Association for Research on the Thymus Database Study.

answer: @entity5 :: (MESH:D009369,Disease) :: ['thymoma in stage II and III thymic epithelial tumors']


abstract: UNASSIGNED: @entity1211 ( @entity1211 ) remains an important complication after total knee arthroplasty (TKA). Systemic thrombin generation starts perioperatively. @entity32 , characterized by a rise in @entity650 ( @entity650 ), initiates the coagulation cascade, but low-dose @entity230 can reduce post-TKA @entity650 levels. This double-blinded, randomized, placebo-controlled study enrolled 30 @entity1 undergoing unilateral TKA to assess the effect of perioperative @entity230 on serum prothrombin fragment (PF1.2), a marker of thrombin generation, and plasmin-alpha-2-antiplasmin complex (PAP), a marker of fibrinolysis. Study @entity1 received 100   mg of intravenous @entity701 2   h prior to surgery, and controls received normal saline. Blood samples, drawn pre-incision and at 4   h post tourniquet release, were assayed for PF1.2 and PAP. The study group had significantly lower mean PF1.2 at 4   h compared to controls (616        358   pMol/L vs. 936        332   pMol/L, p   =   0.037). The mean rise in PF1.2 in the control group was significantly greater compared to the study group (672        173   pMol/L vs. 350        211   pMol/L, p   <   0.001). Mean PAP was higher in the study group at 4   h (1639        823     g/L vs. 1087        536     g/L), but did not reach statistical significance (p   =   0.07). These results may have clinical implications in terms of postoperative @entity1211 risk and management.    2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

title: Effects of XXXX on thrombogenic markers in @entity1 undergoing unilateral total knee arthroplasty: A prospective, double-blind, randomized controlled trial.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['hydrocortisone']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['Venous thromboembolism', 'VTE']

answer: @entity230 :: (MESH:D013256,Chemical) :: ['steroids']


abstract: UNASSIGNED: @entity1211 ( @entity1211 ) remains an important complication after total knee arthroplasty (TKA). Systemic thrombin generation starts perioperatively. @entity32 , characterized by a rise in @entity650 ( @entity650 ), initiates the coagulation cascade, but low-dose @entity230 can reduce post-TKA @entity650 levels. This double-blinded, randomized, placebo-controlled study enrolled 30 @entity1 undergoing unilateral TKA to assess the effect of perioperative @entity230 on serum prothrombin fragment (PF1.2), a marker of thrombin generation, and plasmin-alpha-2-antiplasmin complex (PAP), a marker of fibrinolysis. Study @entity1 received 100   mg of intravenous @entity701 2   h prior to surgery, and controls received normal saline. Blood samples, drawn pre-incision and at 4   h post tourniquet release, were assayed for PF1.2 and PAP. The study group had significantly lower mean PF1.2 at 4   h compared to controls (616        358   pMol/L vs. 936        332   pMol/L, p   =   0.037). The mean rise in PF1.2 in the control group was significantly greater compared to the study group (672        173   pMol/L vs. 350        211   pMol/L, p   <   0.001). Mean PAP was higher in the study group at 4   h (1639        823     g/L vs. 1087        536     g/L), but did not reach statistical significance (p   =   0.07). These results may have clinical implications in terms of postoperative @entity1211 risk and management.    2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res.

title: Effects of @entity230 on thrombogenic markers in XXXX undergoing unilateral total knee arthroplasty: A prospective, double-blind, randomized controlled trial.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION: @entity239 ( @entity239 ) is a multi-factorial disease involving physiological as well as psychological factors. The aim of the study was to investigate a multidisciplinary inpatient treatment with emphasis on @entity221 therapy by @entity1 with @entity158 . MATERIALS AND METHODS: The study involved 104 @entity1 suffering from severely progressive @entity239 . A convenience sample and a prospective cohort design were used. The @entity1 were treated in an acute hospital focusing on @entity158 . One @entity1 group was treated with inclusion of @entity221 therapy and the other group without. The therapy density (number of performed therapies per @entity1 ) was determined for every @entity1 . Functional capacity measured by the Hannover functional status questionnaire (Funktionsfragebogen Hannover) and symptoms (von Zerssen complaint list) were analyzed for both groups on admission and on discharge. RESULTS: On admission, no significant difference could be established between control group (CG; multimodal without @entity221 ) and @entity221 group (HG; multimodal with @entity221 ) (functional capacity, P=0.936). Functional capacity improved for the CG and the HG. On discharge, there was a significant difference between the two groups (functional capacity, P=0.039). There were no significant differences in @entity239 symptoms between CG (mean 41.8) and HG (mean 41.8) on their admission to hospital (P=0.988). On discharge, there was a significant difference (P=0.024) between the two groups (HG, mean 30.6; CG, mean 36.6). The inpatient therapy of @entity1 with severely progressive @entity239 is characterized by a high frequency of therapy input. CONCLUSION: @entity239 , especially with severe progression and a high degree of chronification, demands a multidisciplinary approach. In addition to the use of complementary medical procedures, integration of @entity221 in the treatment process is a useful option.

title: XXXX with severe forms of progression in a multidisciplinary therapy setting with emphasis on @entity221 therapy - a prospective controlled study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia', 'FMS', 'Fibromyalgia syndrome']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['rheumatologic pain therapy and multidisciplinary complementary medicine', 'widespread pain']

answer: @entity239 :: (MESH:D005356,Disease) :: ['Fibromyalgia']


abstract: INTRODUCTION: @entity239 ( @entity239 ) is a multi-factorial disease involving physiological as well as psychological factors. The aim of the study was to investigate a multidisciplinary inpatient treatment with emphasis on @entity221 therapy by @entity1 with @entity158 . MATERIALS AND METHODS: The study involved 104 @entity1 suffering from severely progressive @entity239 . A convenience sample and a prospective cohort design were used. The @entity1 were treated in an acute hospital focusing on @entity158 . One @entity1 group was treated with inclusion of @entity221 therapy and the other group without. The therapy density (number of performed therapies per @entity1 ) was determined for every @entity1 . Functional capacity measured by the Hannover functional status questionnaire (Funktionsfragebogen Hannover) and symptoms (von Zerssen complaint list) were analyzed for both groups on admission and on discharge. RESULTS: On admission, no significant difference could be established between control group (CG; multimodal without @entity221 ) and @entity221 group (HG; multimodal with @entity221 ) (functional capacity, P=0.936). Functional capacity improved for the CG and the HG. On discharge, there was a significant difference between the two groups (functional capacity, P=0.039). There were no significant differences in @entity239 symptoms between CG (mean 41.8) and HG (mean 41.8) on their admission to hospital (P=0.988). On discharge, there was a significant difference (P=0.024) between the two groups (HG, mean 30.6; CG, mean 36.6). The inpatient therapy of @entity1 with severely progressive @entity239 is characterized by a high frequency of therapy input. CONCLUSION: @entity239 , especially with severe progression and a high degree of chronification, demands a multidisciplinary approach. In addition to the use of complementary medical procedures, integration of @entity221 in the treatment process is a useful option.

title: @entity239 with severe forms of progression in a multidisciplinary therapy setting with emphasis on XXXX therapy - a prospective controlled study.

answer: @entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']


abstract: OBJECTIVE: Our objective was to understand the relationship between optimal diabetes control, as defined by @entity497 ( @entity497 ), and adverse health outcomes including @entity341 ( @entity341 ) visits, hospitalizations, 30-day rehospitalization, @entity1213 ( @entity1213 ) stay, and mortality. @entity1 AND METHODS: In 2009, we conducted a retrospective cohort study of empaneled Employee and @entity497 @entity1 with @entity6 . We followed @entity1 from 1 September 2009 until 30 June 2011 for hospitalization and until 5 January 2014 for mortality. Optimal control of @entity6 was defined as achieving the following three measures: low-density lipoprotein (LDL) @entity165 <100 mg/mL, blood pressure <140/90 mmHg, and hemoglobin A1c <8%. Using the electronic medical record, we assessed hospitalizations, @entity341 visits, @entity1213 stays, 30-day rehospitalizations, and mortality. The chi-square or Wilcoxon rank-sum tests were used to compare those with and without optimal control. We used Cox proportional hazard models to estimate the associations between optimal @entity6 status and each outcome. RESULTS: We identified 5,731 empaneled @entity1 with @entity6 ; 2,842 (49.6%) were in the optimal control category. After adjustment, we observed that non-optimally controlled @entity1 had higher risks for hospitalization (hazard ratio [HR] 1.11; 95% confidence interval [CI] 1.00-1.23), @entity341 visits (HR 1.15; 95% CI 1.06-1.25), and mortality (HR 1.29; 95% CI 1.09-1.53) than @entity6 @entity1 with optimal control. No differences were observed in @entity1213 stay or 30-day rehospitalization. CONCLUSION: @entity6 @entity1 without optimal control had higher risks of adverse health outcomes than those with optimal control. @entity1 with optimal control defined by the @entity497 were associated with decreased morbidity and mortality.

title: Health outcomes in @entity6 measured with XXXX quality metrics.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients', 'PATIENTS']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetic', 'diabetic', 'diabetes mellitus']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity497 :: ('MESH:D003147', 'Disease') :: ['MCM', 'Community Health', 'Minnesota Community Measurement']

entities_list: @entity1213 :: ('MESH:D012555', 'Disease') :: ['intensive care unit', 'ICU']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity497 :: (MESH:D003147,Disease) :: ['Minnesota Community Measurement']


abstract: OBJECTIVE: Our objective was to understand the relationship between optimal diabetes control, as defined by @entity497 ( @entity497 ), and adverse health outcomes including @entity341 ( @entity341 ) visits, hospitalizations, 30-day rehospitalization, @entity1213 ( @entity1213 ) stay, and mortality. @entity1 AND METHODS: In 2009, we conducted a retrospective cohort study of empaneled Employee and @entity497 @entity1 with @entity6 . We followed @entity1 from 1 September 2009 until 30 June 2011 for hospitalization and until 5 January 2014 for mortality. Optimal control of @entity6 was defined as achieving the following three measures: low-density lipoprotein (LDL) @entity165 <100 mg/mL, blood pressure <140/90 mmHg, and hemoglobin A1c <8%. Using the electronic medical record, we assessed hospitalizations, @entity341 visits, @entity1213 stays, 30-day rehospitalizations, and mortality. The chi-square or Wilcoxon rank-sum tests were used to compare those with and without optimal control. We used Cox proportional hazard models to estimate the associations between optimal @entity6 status and each outcome. RESULTS: We identified 5,731 empaneled @entity1 with @entity6 ; 2,842 (49.6%) were in the optimal control category. After adjustment, we observed that non-optimally controlled @entity1 had higher risks for hospitalization (hazard ratio [HR] 1.11; 95% confidence interval [CI] 1.00-1.23), @entity341 visits (HR 1.15; 95% CI 1.06-1.25), and mortality (HR 1.29; 95% CI 1.09-1.53) than @entity6 @entity1 with optimal control. No differences were observed in @entity1213 stay or 30-day rehospitalization. CONCLUSION: @entity6 @entity1 without optimal control had higher risks of adverse health outcomes than those with optimal control. @entity1 with optimal control defined by the @entity497 were associated with decreased morbidity and mortality.

title: Health outcomes in XXXX measured with @entity497 quality metrics.

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetics']


abstract: PURPOSE: We investigated the effect of Katsura-uri (Japanese pickling @entity2487 ; @entity2487 . conomon) on energy metabolism during exercise in @entity1 and animal studies. METHODS: Eight healthy @entity1 (mean age, 21.4      0.7  years) participated in a single-blind, crossover study. Thirty minutes after ingesting the Katsura-uri drink or placebo drink, they exercised on a cycle ergometer at 40% maximal heart rate for 30  min. Respiratory gas analysis was performed during exercise to examine @entity26 consumption and substrate utilization. Blood biochemical parameters were evaluated during exercise. In the animal study, the effect of @entity71460 ( @entity8642 ), a Katsura-uri derived component was examined in @entity19 . Immediately after running at 25  m/min for 30  min, biochemical parameters in the hind limb muscle and blood of @entity19 were measured. RESULTS: @entity26 consumption during exercise was higher in the Katsura-uri condition (19.8      3.5  mL/kg/min) than the placebo condition (18.6      3.0  mL/kg/min) (P  <  0.05). The elevation of blood @entity880 was lower in the Katsura-uri condition (1.7      0.4  mM) than the placebo condition (2.2      0.6  mM) 15  min after beginning exercise (P  <  0.05). There was a higher positive correlation between @entity880 concentration and @entity1735 oxidation during exercise in the Katsura-uri condition (R(2)  =  0.86) compared to the placebo condition (R(2)  =  0.47). The decrease in intermuscular pH and the increase in blood @entity880 following exercise were prevented by @entity8642 supplementation (250  ppm) with significant differences in the @entity8642 -supplemented group compared to the control group. CONCLUSIONS: These results suggest that the ingestion of Katsura-uri and/or @entity8642 improves @entity413 metabolism and acidification in skeletal muscles during exercise in @entity1 and animal studies.

title: The effect of Katsura-uri (Japanese pickling XXXX , @entity2487 . conomon) and its derived ingredient @entity71460 on energy metabolism during aerobic exercise.

entities_list: @entity2487 :: ('3656', 'Species') :: ['melon', 'Cucumis melo var']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen', 'Oxygen']

entities_list: @entity71460 :: ('MESH:C118653', 'Chemical') :: ['methylthioacetic acid']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity2487 :: (3656,Species) :: ['melon']


abstract: PURPOSE: We investigated the effect of Katsura-uri (Japanese pickling @entity2487 ; @entity2487 . conomon) on energy metabolism during exercise in @entity1 and animal studies. METHODS: Eight healthy @entity1 (mean age, 21.4      0.7  years) participated in a single-blind, crossover study. Thirty minutes after ingesting the Katsura-uri drink or placebo drink, they exercised on a cycle ergometer at 40% maximal heart rate for 30  min. Respiratory gas analysis was performed during exercise to examine @entity26 consumption and substrate utilization. Blood biochemical parameters were evaluated during exercise. In the animal study, the effect of @entity71460 ( @entity8642 ), a Katsura-uri derived component was examined in @entity19 . Immediately after running at 25  m/min for 30  min, biochemical parameters in the hind limb muscle and blood of @entity19 were measured. RESULTS: @entity26 consumption during exercise was higher in the Katsura-uri condition (19.8      3.5  mL/kg/min) than the placebo condition (18.6      3.0  mL/kg/min) (P  <  0.05). The elevation of blood @entity880 was lower in the Katsura-uri condition (1.7      0.4  mM) than the placebo condition (2.2      0.6  mM) 15  min after beginning exercise (P  <  0.05). There was a higher positive correlation between @entity880 concentration and @entity1735 oxidation during exercise in the Katsura-uri condition (R(2)  =  0.86) compared to the placebo condition (R(2)  =  0.47). The decrease in intermuscular pH and the increase in blood @entity880 following exercise were prevented by @entity8642 supplementation (250  ppm) with significant differences in the @entity8642 -supplemented group compared to the control group. CONCLUSIONS: These results suggest that the ingestion of Katsura-uri and/or @entity8642 improves @entity413 metabolism and acidification in skeletal muscles during exercise in @entity1 and animal studies.

title: The effect of Katsura-uri (Japanese pickling @entity2487 , XXXX . conomon) and its derived ingredient @entity71460 on energy metabolism during aerobic exercise.

answer: @entity2487 :: (3656,Species) :: ['Cucumis melo var']


abstract: PURPOSE: We investigated the effect of Katsura-uri (Japanese pickling @entity2487 ; @entity2487 . conomon) on energy metabolism during exercise in @entity1 and animal studies. METHODS: Eight healthy @entity1 (mean age, 21.4      0.7  years) participated in a single-blind, crossover study. Thirty minutes after ingesting the Katsura-uri drink or placebo drink, they exercised on a cycle ergometer at 40% maximal heart rate for 30  min. Respiratory gas analysis was performed during exercise to examine @entity26 consumption and substrate utilization. Blood biochemical parameters were evaluated during exercise. In the animal study, the effect of @entity71460 ( @entity8642 ), a Katsura-uri derived component was examined in @entity19 . Immediately after running at 25  m/min for 30  min, biochemical parameters in the hind limb muscle and blood of @entity19 were measured. RESULTS: @entity26 consumption during exercise was higher in the Katsura-uri condition (19.8      3.5  mL/kg/min) than the placebo condition (18.6      3.0  mL/kg/min) (P  <  0.05). The elevation of blood @entity880 was lower in the Katsura-uri condition (1.7      0.4  mM) than the placebo condition (2.2      0.6  mM) 15  min after beginning exercise (P  <  0.05). There was a higher positive correlation between @entity880 concentration and @entity1735 oxidation during exercise in the Katsura-uri condition (R(2)  =  0.86) compared to the placebo condition (R(2)  =  0.47). The decrease in intermuscular pH and the increase in blood @entity880 following exercise were prevented by @entity8642 supplementation (250  ppm) with significant differences in the @entity8642 -supplemented group compared to the control group. CONCLUSIONS: These results suggest that the ingestion of Katsura-uri and/or @entity8642 improves @entity413 metabolism and acidification in skeletal muscles during exercise in @entity1 and animal studies.

title: The effect of Katsura-uri (Japanese pickling @entity2487 , @entity2487 . conomon) and its derived ingredient XXXX on energy metabolism during aerobic exercise.

answer: @entity71460 :: (MESH:C118653,Chemical) :: ['methylthioacetic acid']


abstract: BACKGROUND AND OBJECTIVES: Several clinical studies suggest that interstitial photodynamic therapy (I-PDT) may benefit @entity1 with locally advanced @entity135 (LAHNC). For I-PDT, the therapeutic light is delivered through optical fibers inserted into the target @entity5 . The complex anatomy of the head and neck requires careful planning of fiber insertions. Often the fibers' location and @entity5 optical properties may vary from the original plan therefore pretreatment planning needs near real-time updating to account for any changes. The purpose of this work was to develop a @entity1417 ( @entity1417 ) approach for near real-time simulation of light propagation in LAHNC. METHODS: Our previously developed @entity1417 for modeling light propagation in skin tissue was modified to simulate light propagation from interstitial optical fibers. The modified model was validated by comparing the calculations with measurements in a phantom mimicking @entity5 optical properties. We investigated the impact of mesh element size and growth rate on the computation time, and defined optimal settings for the @entity1417 . We demonstrated how the optimized @entity1417 can be used for simulating light propagation in two cases of LAHNC amenable to I-PDT, as proof-of-concept. RESULTS: The modified @entity1417 was in agreement with the measurements (P   =   0.0271). The optimal maximum mesh size and growth rate were 0.005-0.02   m and 2-2.5   m/m, respectively. Using these settings the computation time for simulating light propagation in LAHNC was reduced from 25.9 to 3.7   minutes in one case, and 10.1 to 4   minutes in another case. There were minor differences (1.62%, 1.13%) between the radiant exposures calculated with either mesh in both cases. CONCLUSIONS: Our @entity1417 approach can be used to model light propagation from diffused optical fibers in complex heterogeneous geometries representing LAHNC. There is a range of maximum element size (MES) and maximum element growth rate (MEGR) that can be used to minimize the computation time of the @entity1417 to 4   minutes. Lasers Surg. Med. 47:60-67, 2015.    2015 Wiley Periodicals, Inc.

title: A new finite element approach for near real-time simulation of light propagation in locally advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer']

entities_list: @entity1417 :: ('MESH:C565217', 'Disease') :: ['FEA', 'finite element analysis']

answer: @entity135 :: (MESH:D006258,Disease) :: ['head and neck tumors']


abstract: PURPOSE: We were going to access the effect of @entity1212 ( @entity1212 ) on post-thrombotic syndrome (PTS) and the long term effects of iliac vein stenting in acute iliofemoral @entity1150 (IFDVT). MATERIALS AND METHODS: Fifty-six limbs in fifty-one @entity1 (46 unilateral, 5 bilateral) were included from November 2001 through December 2007. @entity1 were classified based on the method of treatment: with stent implantation (n=37) and without stent implantation (n=19). The Villalta scale was chosen to assess for severity of PTS. The validated outcome measures were compared between the treatment groups. Statistical analysis was estimated according to the Kaplan-Meier test and Pearson chi-square test. RESULTS: Mean age was 57  13 years (range, 27-76 years). Mean follow up duration was 56  12 months (range, 24-144 months). Overall 5-year primary patency rate was 66.1% (77.8% in the stenting group and 42.1% in the non-stenting group) and showed statistically significant difference between the two groups (P=0.02). The recurrence rate of @entity1150 was 10/37 (27.1%) in the stenting group and 11/19 (57.9%) in the non-stenting group, respectively, which showed statistically significant difference between the two groups (P=0.024). Overall incidence of mild PTS was 8/30 (26.7%): 4/13 (30.8%) in the stenting group and 4/17 (23.5%) in the non-stenting group. None of the other factors showed statistically significant difference between the groups. CONCLUSION: Long term results of @entity1212 in IFDVT were acceptable, and stent implantation to the iliac segment seems to have a good effect on the long term results. Therefore @entity1212 with simultaneous stenting is recommended to improve long term results of IFDVT, if indicated.

title: Long-Term Results of Catheter-Directed Thrombolysis Combined with Iliac Vein Stenting for Iliofemoral XXXX .

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1212 :: ('MESH:D055499', 'Disease') :: ['catheter-directed thrombolytic therapy', 'CDT']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['Deep Vein Thrombosis']


abstract: UNASSIGNED: We investigated the treatment of @entity75 with @entity3503 laser as an alternative therapy to surgical excision. The charts of 73 @entity1 with 95 lesions treated with @entity3503 laser photocoagulation were reviewed retrospectively. In all @entity1 , the procedure was performed for cosmetic reasons. The laser spot size ranged from 50 to 200   m, the power varied from 300 to 700  mW, and the exposure time ranged between 0.1 and 0.2  s. The lesions were mostly located on the upper eyelid (66  %); the lid margin was involved in 30 cases. The mean follow-up time was 7.2        3.5  months (range 3-15  months). A histopathological diagnosis was confirmed for 81 lesions (85.3  %). All @entity1 were satisfied with the cosmetic result. No @entity3816 occurred, and none of the @entity1 complained of @entity158 during laser application. All wounds epithelialized in 3-4  weeks with skin that appeared normal. @entity4182 of the treated areas were observed in three cases. No recurrence occurred during the follow-up period. @entity3503 laser-assisted benign eyelid @entity5 excision is a useful, cheap, accessible, and well-tolerated alternative to traditional surgery.

title: XXXX laser-assisted treatment of @entity75 .

entities_list: @entity4182 :: ('MESH:D017496', 'Disease') :: ['Hypopigmentation']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['benign eyelid lesions']

entities_list: @entity3816 :: ('MESH:D007431', 'Disease') :: ['intraoperative complications']

answer: @entity3503 :: (MESH:D001128,Chemical) :: ['Argon']


abstract: UNASSIGNED: We investigated the treatment of @entity75 with @entity3503 laser as an alternative therapy to surgical excision. The charts of 73 @entity1 with 95 lesions treated with @entity3503 laser photocoagulation were reviewed retrospectively. In all @entity1 , the procedure was performed for cosmetic reasons. The laser spot size ranged from 50 to 200   m, the power varied from 300 to 700  mW, and the exposure time ranged between 0.1 and 0.2  s. The lesions were mostly located on the upper eyelid (66  %); the lid margin was involved in 30 cases. The mean follow-up time was 7.2        3.5  months (range 3-15  months). A histopathological diagnosis was confirmed for 81 lesions (85.3  %). All @entity1 were satisfied with the cosmetic result. No @entity3816 occurred, and none of the @entity1 complained of @entity158 during laser application. All wounds epithelialized in 3-4  weeks with skin that appeared normal. @entity4182 of the treated areas were observed in three cases. No recurrence occurred during the follow-up period. @entity3503 laser-assisted benign eyelid @entity5 excision is a useful, cheap, accessible, and well-tolerated alternative to traditional surgery.

title: @entity3503 laser-assisted treatment of XXXX .

answer: @entity75 :: (MESH:D001927,Disease) :: ['benign eyelid lesions']


abstract: Nasal transepithelial electrical @entity841 ( @entity841 ) was estimated in vivo in normal @entity1 subjects. The @entity841 between a bridge perfused with Ringer's solution placed on the nasal mucosal surface and a reference electrode in a subcutaneous space was recorded. The magnitude of the @entity841 depended upon the region of the nasal cavity touched by the exploring bridge. The @entity841 values ranged from -4 mV (lumen negative) on the anterior tip of the inferior turbinate to approximately -30 mV on the inferior surface of the turbinate. Biopsies of the anterior turbinate were characterized by squamous epithelial cells, whereas ciliated cells dominated the epithelium from regions of higher @entity841 . Epithelial abrasion abolished @entity841 . No differences in @entity841 were noted between the left and right nasal cavities, and repetitive measurements of @entity841 at the same site yielded comparable values. No differences in nasal @entity841 were noted between young male or female subjects but @entity841 declined as a function of age. @entity6478 (10(-4)M) and @entity3303 (10(-1)M) reduced @entity841 (-59% and -30%, respectively), whereas @entity2379 (5 X 10(-5)M) raised @entity841 (+29%). We concluded that nasal @entity841 can be accurately measured in vivo in @entity1 , and that measurements of nasal bioelectric properties may serve as a relatively noninvasive index of respiratory epithelial function.

title: Measurements of nasal transepithelial electric potential differences in normal XXXX subjects in vivo.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity6478 :: ('MESH:D000584', 'Chemical') :: ['Amiloride']

entities_list: @entity841 :: ('MESH:C537245', 'Disease') :: ['potential difference', 'PD']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVES: To describe the clinical characteristics, diagnostic methods, treatment modalities, and complications, and identify the mortality risk factors, of @entity1 with short-term persistent pulmonary @entity101 of the newborn (PPHN). METHODS: The clinical data of @entity1 diagnosed with PPHN at Hat Yai Hospital from January 2010 to February 2014 were retrospectively reviewed. Cox proportional hazard regression analysis was performed to assess factors associated with mortality. RESULTS: The records of 119 @entity1 were analyzed. Of these, 47 died giving an in-hospital mortality rate of 39.5%. The prevalence of PPHN (based on inborn births) was 2.8 per 1000 live births. The mean gestational age and birth weight were 39.1        1.6 weeks and 3044        563   g, respectively. Multivariate Cox regression analysis indicated that pneumothorax [adjusted hazard ratio (HR)   =   2.07 (95% CI 1.09-3.93)] and @entity810 [adjusted HR   =   2.99 (95% CI 1.59-5.61)] were factors associated independently with an increased risk for @entity204 , while @entity1 who received total parenteral nutrition [adjusted HR   =   0.22 (95% CI 0.10-0.50)] had lower mortality. CONCLUSION: A high mortality rate of PPHN was observed in this study. Significantly higher mortality was noted in @entity1 complicated with pneumothorax and @entity810 .

title: @entity810 and pneumothorax are risk factors for mortality in persistent pulmonary XXXX of the newborn in Thai neonates.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injury']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: OBJECTIVES: To describe the clinical characteristics, diagnostic methods, treatment modalities, and complications, and identify the mortality risk factors, of @entity1 with short-term persistent pulmonary @entity101 of the newborn (PPHN). METHODS: The clinical data of @entity1 diagnosed with PPHN at Hat Yai Hospital from January 2010 to February 2014 were retrospectively reviewed. Cox proportional hazard regression analysis was performed to assess factors associated with mortality. RESULTS: The records of 119 @entity1 were analyzed. Of these, 47 died giving an in-hospital mortality rate of 39.5%. The prevalence of PPHN (based on inborn births) was 2.8 per 1000 live births. The mean gestational age and birth weight were 39.1        1.6 weeks and 3044        563   g, respectively. Multivariate Cox regression analysis indicated that pneumothorax [adjusted hazard ratio (HR)   =   2.07 (95% CI 1.09-3.93)] and @entity810 [adjusted HR   =   2.99 (95% CI 1.59-5.61)] were factors associated independently with an increased risk for @entity204 , while @entity1 who received total parenteral nutrition [adjusted HR   =   0.22 (95% CI 0.10-0.50)] had lower mortality. CONCLUSION: A high mortality rate of PPHN was observed in this study. Significantly higher mortality was noted in @entity1 complicated with pneumothorax and @entity810 .

title: XXXX and pneumothorax are risk factors for mortality in persistent pulmonary @entity101 of the newborn in Thai neonates.

answer: @entity810 :: (MESH:D058186,Disease) :: ['Acute kidney injury']


abstract: OBJECTIVE: To compare rates of clinical pregnancy (CPR) and live birth (LBR) following embryo transfer (ET) performed by reproductive endocrinology and @entity249 (REI) fellows before and after a prolonged lapse in clinical training due to an 18-month @entity717 . DESIGN: Retrospective cohort study. SETTING: Not applicable. @entity1 (S): All @entity1 undergoing @entity52 ( @entity52 ) and @entity52 -intracytoplasmic sperm injection (ICSI) cycles with ET performed by REI fellows from August 2003 to July  2012. INTERVENTION: Eighteen-month lapse in clinical training of REI fellows. MAIN OUTCOME MEASURE(S): CPR and LBR before and after the lapse in clinical training were calculated and compared per fellow and as a composite group. Alternating logistic regression models were used to calculate the odds of clinical pregnancy and live birth following transfers performed before and after the lapse in training. RESULT(S): Unadjusted odds of clinical pregnancy and live birth were similar between the two time periods both for individual fellows and for the composite group. Alternate logistic regression analysis revealed no significant difference in CPR (odds ratio [OR] 0.94, 95% confidence interval [CI] 0.83-1.07) or LBR (OR 1.05, 95% CI 0.94-1.18) after the lapse in training compared with before. CONCLUSION(S): A @entity717 is common in REI fellowship training programs. This prolonged departure from clinical training does not appear to negatively affect pregnancy outcome following fellow ET.

title: Lapse in embryo transfer training does not negatively affect clinical  pregnancy rates for reproductive endocrinology and XXXX fellows.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'PATIENT']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['research rotation']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in  vitro fertilization']

answer: @entity249 :: (MESH:D007246,Disease) :: ['infertility']


abstract: BACKGROUND: Clinical characteristics and optimal treatment strategies for spindle cell/sclerosing @entity980 (ssRMS) have not been well established because of its rarity. PROCEDURE: Retrospective re-evaluation of @entity242 specimens (1997-2014) identified 16 ssRMSs (median age 20 years, range 7-39 years). Clinicopathological features, clinical course, and outcome were analyzed. RESULTS: Primary disease sites were the head and neck (10 cases) and other regions (6 cases). Nine cases were at Intergroup @entity980 Study preoperative stage 3. The @entity5 were >5   cm in 13 cases. Two @entity1 had lymph node @entity3 , but none had distant @entity3 at presentation. At follow-up (median period 39 months, range 4.6-201), seven @entity1 were alive without disease. Among nine @entity1 treated with the @entity1891 , @entity4316 , and @entity786 (VAC) regimen, five responded well, with four surviving free of disease. Among ten @entity1 with recurrent or progressive disease, three experienced local recurrence, four had distant @entity3 , and three had both. None exhibited @entity236 . Eight of the ten @entity1 died in median time from relapse to @entity204 of 18 months (range 11-56). CONCLUSIONS: Although most ssRMSs present as a bulky @entity5 , nodal or distant @entity3 are rare at presentation. ssRMSs initially show good response to VAC, but >50% of @entity5 recur or progress; these data suggest a worse prognosis of ssRMS compared to the pediatric embryonal variant. As relapse typically occurs as local or distant solitary lesion without @entity236 , localized treatment combined with chemotherapy would contribute to improve the prognosis of recurrent ssRMS. Pediatr @entity5    2014 Wiley Periodicals, Inc.

title: Clinicopathologic analysis of spindle cell/sclerosing XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors', 'primary tumors', 'Blood Cancer']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity4316 :: ('MESH:D003609', 'Chemical') :: ['actinomycin']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity980 :: ('MESH:D012208', 'Disease') :: ['Rhabdomyosarcoma', 'rhabdomyosarcoma']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow invasion']

answer: @entity980 :: (MESH:D012208,Disease) :: ['rhabdomyosarcoma']


abstract: UNASSIGNED: @entity1 with @entity1957 ( @entity1957 ) are commonly seen by physiotherapists and there is growing evidence to support a physical rehabilitation approach. There are, however, few descriptions in the literature of the content of successful physiotherapy treatment. This prospective cohort study reports the practicalities and outcomes of a pilot 5-day physiotherapy programme. @entity1 were referred from a specialist @entity717 clinic. The treatment consisted of education and movement retraining, with a long-term self-management focus. Education and movement retraining was based on a pathophysiological model for @entity1957 that stresses the importance of self-focussed attention and illness belief. @entity1 were assessed at baseline, end of treatment and 3-month follow-up. 47 @entity1 completed the programme, mean symptom duration was 5.5  years, 64  % were unemployed due to ill health. At the end of treatment, 65  % rated their symptoms as "very much improved" or "much improved", this reduced to 55  % at 3  months. At follow-up, there was a significant improvement in physical domains of the SF-36, Berg Balance Scale and 10 Metre Timed Walk. Measures of mental health did not change. This prospective cohort study adds to the growing evidence that supports the use of specialist physiotherapy treatment for @entity1957 . Improvements here were made despite the cohort having characteristics associated with poor prognosis. We argue that specific treatment techniques are important and have the potential to improve physical function, quality of life and may prove to be a cost-effective treatment for selected @entity1 with @entity1957 .

title: Outcomes of a 5-day physiotherapy programme for functional (psychogenic) XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1957 :: ('MESH:D019957', 'Disease') :: ['FMD', 'functional motor disorder']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['movement disorders']

answer: @entity1957 :: (MESH:D019957,Disease) :: ['motor disorders']


abstract: UNASSIGNED: Stress @entity174 of the first rib on the dominant throwing side are well-described in baseball pitchers; however, lower @entity174 are not commonly recognized. While common in other sports such as rowing, there is scant literature on these injuries in baseball. Intercostal muscle strains are commonly diagnosed in baseball pitchers and have a nearly identical presentation but also a highly variable healing time. The diagnosis of a rib stress @entity174 can predict a more protracted recovery. This case series presents two collegiate baseball pitchers on one team during the same season who were originally diagnosed with @entity121 , which following magnetic resonance imaging (MRI) were found to have actually sustained lower thoracic rib @entity1642 . The first sustained a stress @entity174 of the posterior aspect of the right 8th rib on the dominant arm side, while the second presented with a left-sided 10th rib stress @entity174 on the nondominant arm side. In both cases, MRI was used to visualize the @entity174 as plain radiographs are insensitive and commonly negative early in @entity1 presentation. @entity1 were treated with activity modification, and symptomatic management for 4-6 weeks with a graduated return to throwing and competition by 8-10 weeks. The repetitive high stresses incurred by pitching may cause either dominant or nondominant rib @entity1642 and this should be included in the differential diagnosis of @entity764 in throwers. It is especially important that athletic trainers and team physicians consider this diagnosis, as @entity174 may have a protracted course and delayed return to play. Additionally, using the appropriate imaging techniques to establish an accurate diagnosis can help inform return-to-play decisions, which have important practical applications in baseball, such as roster management and eligibility.

title: Lower thoracic rib XXXX in baseball pitchers.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patient']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['intercostal muscle strains']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'thoracic rib fractures', 'fracture', 'rib fractures']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['thoracic injuries']

entities_list: @entity1642 :: ('MESH:D015775', 'Disease') :: ['stress fractures']

answer: @entity1642 :: (MESH:D015775,Disease) :: ['stress fractures']


abstract: PURPOSE: To evaluate the efficacy of a knowledge-based iterative model reconstruction (IMR) algorithm for reducing image noise in ultralow-dose (ULD) CT for @entity1791 . MATERIALS AND METHODS: A total of 103 @entity1 diagnosed with urinary stones (n = 276) were enrolled. Regular dose (RD) scans (120 kV and 150 mAs, maximal tube current in dose modulation) were reconstructed using filtered back-projection ( @entity30220 , RD- @entity30220 ), and ULD scans (100 kV and 20 mAs, fixed tube current) were reconstructed with @entity30220 (ULD- @entity30220 ), statistical iterative reconstruction (IR; ULD-iDose), and a knowledge-based IMR algorithm (ULD-IMR). Prospective interpretations of the two scans were performed with respect to radiation dose, objective image noise, and subjective assessment. The subjective assessment was also evaluated with regard to each @entity1 's body mass index (BMI, < 25 or >=  25 kg/m(2)). Using RD CT (RD- @entity30220 ) as the reference standard, two reviewers assessed the diagnostic performance and inter-observer agreement for ULD-IMR. RESULT: The average effective doses with RD CT and ULD CT were 8.31 and 0.68 @entity2073 , respectively, and the average radiation dose reduction rate was 91.82% (p < 0.01). The lowest objective image noise was observed with ULD-IMR (p < 0.01). Subjective assessment in ULD-IMR was comparable to that of RD- @entity30220 , although RD- @entity30220 remained statistically superior. For BMI, there was a statistically significant difference in subjective image quality between the normal (4.7    0.54) and overweight or @entity28 groups (4.2    0.5) (p < 0.05). The ULD-IMR showed a greater than 75% concordant rate in overall stones and 100% in ureter stones larger than 3 mm. However, for stones <3 mm, neither reviewer had a good detection rate (45.5% and 56.9% for the general and genitourinary radiologist, respectively). Inter-observer agreement was almost perfect (k = 0.82). CONCLUSION: Despite a significant radiation dose reduction, ULD-IMR images were comparable in image quality and noise to RD- @entity30220 images. Furthermore, the diagnostic performance of the ULD non-enhanced CT protocol was comparable to that of the RD scan for diagnosing urinary stones larger than 3 mm.

title: Knowledge-based iterative model reconstruction (IMR) algorithm in ultralow-dose CT for evaluation of XXXX : evaluation of radiation dose reduction, image quality, and diagnostic performance.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1791 :: ('MESH:D052878', 'Disease') :: ['urolithiasis']

answer: @entity1791 :: (MESH:D052878,Disease) :: ['urolithiasis']


abstract: OBJECTIVE: Evaluation of the impact of sequential chemoradiotherapy in high risk @entity1204 ( @entity1204 ). METHODS: Two hundred fifty-four @entity1 with stage IB grade 3, II and III @entity1204 (2009 FIGO staging), were included in this retrospective study. RESULTS: Stage I, II, and III was 24%, 28.7%, and 47.3%, respectively. Grade 3 @entity5 was 53.2% and 71.3% had deep myometrial invasion. One hundred sixty-five @entity1 (65%) underwent pelvic (+/- aortic) lymphadenectomy and 58 (22.8%) had nodal metastases. Ninety-eight @entity1 (38.6%) underwent radiotherapy, 59 (23.2%) chemotherapy, 42 (16.5%) sequential chemoradiotherapy, and 55 (21.7%) were only observed. After a median follow-up of 101 months, 78 @entity1 (30.7%) relapsed and 91 @entity1 (35.8%) died. Sequential chemoradiotherapy improved survival rates in @entity1 who did not undergo nodal evaluation (disease-free survival [DFS], p=0.040; @entity1349 [ @entity1349 ], p=0.024) or pelvic (+/- aortic) lymphadenectomy (DFS, p=0.008; @entity1349 , p=0.021). Sequential chemoradiotherapy improved both DFS (p=0.015) and @entity1349 (p=0.014) in stage III, while only a trend was found for DFS (p=0.210) and @entity1349 (p=0.102) in stage I-II @entity1204 . In the multivariate analysis, only age ( <= 65 years) and sequential chemoradiotherapy were statistically related to the prognosis. CONCLUSION: Sequential chemoradiotherapy improves survival rates in high risk @entity1204 compared with chemotherapy or radiotherapy alone, in particular in stage III.

title: Adjuvant sequential chemo and radiotherapy improves the oncological outcome in high risk XXXX .

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'EC']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']


abstract: BACKGROUND: Slow transit constipation (STC) is associated with @entity1049 . The underlying cause(s) of the abnormalities remain poorly defined. In health, utilizing high resolution fiber-optic manometry, we have described a distal colonic propagating motor pattern with a slow wave frequency of 2-6 cycles per minute (cpm). A high calorie meal caused a rapid and significant increase in this activity, suggesting the intrinsic slow wave activity could be mediated by extrinsic neural input. Utilizing the same protocol our aim was to characterize colonic meal response STC @entity1 . METHODS: A fiber-optic manometry catheter (72 sensors at 1  cm intervals) was colonoscopically placed with the tip clipped at the ascending or transverse colon, in 14 @entity1 with scintigraphically confirmed STC. Manometric recordings were taken, for 2  h pre and post a 700  kCal meal. Data were compared to 12 healthy adults. KEY RESULTS: Prior to and/or after the meal the cyclic propagating motor pattern was identified in 13 of 14 @entity1 . However, the meal, did not increase the cyclic motor pattern (preprandial 7.4      7.6 vs postprandial 8.3      4.5 per/2  h), this is in contrast to the dramatic increase observed in health (8.3      13.3 vs 59.1      89.0 per/2  h; p  <  0.001). CONCLUSIONS _ INFERENCES: In @entity1 with STC a meal fails to induce the normal increase in the distal colonic cyclic propagating motor patterns. We propose that these data may indicate that the normal extrinsic parasympathetic inputs to the colon are attenuated in these @entity1 .

title: XXXX in slow transit constipation defined by high resolution, fibre-optic manometry.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic motor abnormalities']

answer: @entity1049 :: (MESH:D003108,Disease) :: ['Colonic motor abnormalities']


abstract: BACKGROUND:: Obesity is associated with intestinal-specific @entity32 . Nonetheless, a specific role of @entity28 in the etiology of @entity29 is unclear. METHODS:: We conducted a prospective cohort study of U.S. @entity1 enrolled in 1989 in the Nurses' Health Study II. At baseline, we collected information on height, weight, waist and hip circumference, weight at age 18, and body shape at age 20. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs). RESULTS:: Among 111,498 @entity1 (median age, 35 yr), we documented 153 cases of @entity30 ( @entity30 ) and 229 cases of @entity31 ( @entity31 ) more than 18 years of follow-up, encompassing 2,028,769 @entity1 -years. Compared with @entity1 with normal BMI, the multivariate-adjusted hazard ratios of @entity30 were 2.33 (95% CI, 1.15-4.69) for @entity28 @entity1 at age 18 and 1.58 (95% CI, 1.01-2.47) for @entity28 @entity1 at baseline. Increasing weight gain between age 18 and baseline was associated with increased risk of @entity30 (Ptrend = 0.04). Adolescent body habitus was also associated with risk of @entity30 with a multivariate-adjusted hazard ratio of @entity30 of 1.63 (95% CI, 1.07-2.50) for @entity1 with @entity28 compared with @entity1 with a thin/slender body shape. We did not observe a significant association between any of these anthropometric measures and risk of @entity31 . CONCLUSIONS:: In a large prospective cohort of U.S. @entity1 , measures of adiposity were associated with an increased risk of @entity30 but not @entity31 . Additional studies are needed to elucidate the biological mechanisms by which excess adiposity may increase the risk of @entity30 .

title: Measures of Obesity and Risk of @entity30 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'person']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity', 'overweight/obese body shape']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['inflammatory bowel disease']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]

answer: @entity31 :: (MESH:D003093,Disease) :: ['Ulcerative Colitis']


abstract: BACKGROUND:: Obesity is associated with intestinal-specific @entity32 . Nonetheless, a specific role of @entity28 in the etiology of @entity29 is unclear. METHODS:: We conducted a prospective cohort study of U.S. @entity1 enrolled in 1989 in the Nurses' Health Study II. At baseline, we collected information on height, weight, waist and hip circumference, weight at age 18, and body shape at age 20. We used Cox proportional hazard models to calculate hazard ratios and 95% confidence intervals (CIs). RESULTS:: Among 111,498 @entity1 (median age, 35 yr), we documented 153 cases of @entity30 ( @entity30 ) and 229 cases of @entity31 ( @entity31 ) more than 18 years of follow-up, encompassing 2,028,769 @entity1 -years. Compared with @entity1 with normal BMI, the multivariate-adjusted hazard ratios of @entity30 were 2.33 (95% CI, 1.15-4.69) for @entity28 @entity1 at age 18 and 1.58 (95% CI, 1.01-2.47) for @entity28 @entity1 at baseline. Increasing weight gain between age 18 and baseline was associated with increased risk of @entity30 (Ptrend = 0.04). Adolescent body habitus was also associated with risk of @entity30 with a multivariate-adjusted hazard ratio of @entity30 of 1.63 (95% CI, 1.07-2.50) for @entity1 with @entity28 compared with @entity1 with a thin/slender body shape. We did not observe a significant association between any of these anthropometric measures and risk of @entity31 . CONCLUSIONS:: In a large prospective cohort of U.S. @entity1 , measures of adiposity were associated with an increased risk of @entity30 but not @entity31 . Additional studies are needed to elucidate the biological mechanisms by which excess adiposity may increase the risk of @entity30 .

title: Measures of Obesity and Risk of XXXX and @entity31 .

answer: @entity30 :: (MESH:D003424,Disease) :: ['Crohn's Disease']


abstract: OBJECTIVES: @entity146 is often one of the causes to make treatments for M  ni  re's disease more difficult. The aim in the present study is to examine ratios of the @entity11167 and @entity308 in @entity1 with intractable M  ni  re's disease and also relationships between the ratios and surgical results after endolymphatic sac drainage with large doses of @entity230 . METHODS: Between 1998 and 2009, we enrolled 263 intractable M  ni  re's @entity1 and divided into two groups, 207 in surgical group and 56 in non-surgical group. We used the Cornell Medical Index (CMI) and the @entity308 ( @entity308 ) at the diagnosis in our hospital to evaluate their @entity558 before treatments. CMI domains III and IV were defined as @entity11167 and @entity308 scores more than 40 as @entity308 as a matter of convenience. Two years as well as seven years after surgery, @entity1 with vertigo zero/month and hearing change>-10dB were evaluated in success group and the others in non-success group. RESULTS: @entity11167 and @entity308 were diagnosed in approximately 40% and 60%, respectively, of intractable M  ni  re's disease. Our results showed that surgical treatment significantly improved vertigo suppression and @entity393 in @entity1 with no @entity1109 compared with those exhibiting @entity1109 both in surgical and non-surgical groups. Furthermore, surgical results in cases with @entity146 were superior to non-surgical results in cases without mental distress. CONCLUSIONS: All taken together, psychological supports could be necessary for improving results both in the surgical and non-surgical treatments for @entity1 with intractable M  ni  re's disease. Some cases with intractable M  ni  re's disease should really require additional surgical treatments even after psychological therapies.

title: Surgical results and psychological status in XXXX with intractable M  ni  re's disease.

entities_list: @entity11167 :: ('MESH:D009449', 'Disease') :: ['neurosis', 'Neurosis']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Self-rating Depression Scale', 'SDS', 'depression']

entities_list: @entity558 :: ('MESH:C536528', 'Disease') :: ['psychological condition']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental disorder', 'mental disorder']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['psychological symptoms']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing gain']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Adipose tissue is considered to have endocrine properties, including factors that are considered to have angiogenic activity. The current study aimed to evaluate whether there was a difference in the efficacy of bevacizumab for metastatic @entity694 @entity1 according to their BMI (kg/m). A retrospective review of the medical records of consecutive @entity1 who were treated with bevacizumab from diagnosis for metastatic @entity694 between 2005 and 2011 was carried out. Data extracted from medical files included demographics, height, weight, comorbidities, treatment protocols, time @entity5 ( @entity5 ), and time of @entity204 . Variables were further evaluated with respect to @entity5 and @entity1349 ( @entity1349 ). The final analysis included 184 @entity1 . The median @entity5 was 11.7 months and the median survival was 27.6 months. Chemotherapy dose reduction [P>0.001, hazard ratio (HR)=0.6, 95% confidence interval (CI) 0.4-0.8] and male sex (P=0.03, HR=0.7, 95% CI 0.5-1.0) predicted @entity5 . Multivariate analysis indicated that @entity3 at initial presentation and/or @entity6 were associated with worse @entity1349 : the median @entity1349 for @entity6 was 20 versus 28.3 months for @entity1 without @entity6 (P=0.008, HR=2, 95% CI 1.2-3.4) and 23 months for @entity1 with @entity3 at initial presentation versus 31.4 months for recurrent disease (P=0.008, HR=1.6, 95% CI 1.1-2.2). No differences were found for different BMIs subdivided into groups with respect to @entity1349 (P=0.84) or @entity5 (P=0.75). Our study did not show that bevacizumab is less effective in @entity1 with a high BMI. It did show that @entity6 and/or @entity3 at initial diagnosis are associated with a poorer outcome.

title: Bevacizumab for metastatic XXXX : does @entity1 BMI influence survival?

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['shorter TTP', 'TTP', 'to tumor progression']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon cancer']


abstract: UNASSIGNED: Adipose tissue is considered to have endocrine properties, including factors that are considered to have angiogenic activity. The current study aimed to evaluate whether there was a difference in the efficacy of bevacizumab for metastatic @entity694 @entity1 according to their BMI (kg/m). A retrospective review of the medical records of consecutive @entity1 who were treated with bevacizumab from diagnosis for metastatic @entity694 between 2005 and 2011 was carried out. Data extracted from medical files included demographics, height, weight, comorbidities, treatment protocols, time @entity5 ( @entity5 ), and time of @entity204 . Variables were further evaluated with respect to @entity5 and @entity1349 ( @entity1349 ). The final analysis included 184 @entity1 . The median @entity5 was 11.7 months and the median survival was 27.6 months. Chemotherapy dose reduction [P>0.001, hazard ratio (HR)=0.6, 95% confidence interval (CI) 0.4-0.8] and male sex (P=0.03, HR=0.7, 95% CI 0.5-1.0) predicted @entity5 . Multivariate analysis indicated that @entity3 at initial presentation and/or @entity6 were associated with worse @entity1349 : the median @entity1349 for @entity6 was 20 versus 28.3 months for @entity1 without @entity6 (P=0.008, HR=2, 95% CI 1.2-3.4) and 23 months for @entity1 with @entity3 at initial presentation versus 31.4 months for recurrent disease (P=0.008, HR=1.6, 95% CI 1.1-2.2). No differences were found for different BMIs subdivided into groups with respect to @entity1349 (P=0.84) or @entity5 (P=0.75). Our study did not show that bevacizumab is less effective in @entity1 with a high BMI. It did show that @entity6 and/or @entity3 at initial diagnosis are associated with a poorer outcome.

title: Bevacizumab for metastatic @entity694 : does XXXX BMI influence survival?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: PURPOSE: To assess if @entity2048 ( @entity2048 ) occur in @entity1 with @entity3148 ( @entity3148 ). METHODS: A retrospective chart review was conducted in 37 @entity1 with @entity3148 followed at seven different @entity302 centres in Italy, between 2002 and 2014. To assess the possible occurrence of pure @entity2048 or absences associated with myoclonias, @entity2048 were defined according to the following criteria: (i) a sudden onset and interruption of ongoing activities; (ii) bilateral polyspikes or spike-and-wave (SW) complexes; spike SW complexes at 2-4Hz; (iii) duration of @entity5427 : 3-30seconds. RESULTS: Thirty-seven @entity3148 @entity1 (25 @entity1 and 12 @entity1 ) were identified. Nine @entity1 (24.3%) had a history of simple FS during the first year of life. Ten @entity1 (27%) had a family history of @entity302 , and six @entity1 (16.2%) had a family history of FS. In 7/37 (18.9%) @entity1 , during the occurrence of MSs, a total of nineteen brief @entity2048 were captured by video-EEG recordings. @entity2048 occurred both during a brief cluster of rhythmic MSs than after single @entity2045 . The ictal EEG abnormalities observed in @entity1 with @entity2048 were similar to the ictal EEG patterns associated with only myoclonias. No differences in relation to gender, family history, ictal EEG discharge were found between @entity1 with @entity410 with @entity2048 without @entity2048 . CONCLUSIONS: @entity2048 can occur in approximately 20% of @entity3148 @entity1 and the occurrence of @entity2048 , though not essential to formulate the diagnosis, do not automatically exclude the diagnosis of @entity3148 .

title: Do pure XXXX occur in @entity3148 ? A case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'girls', 'boys']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['myoclonic seizures']

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonic jerks']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'paediatric epilepsy']

entities_list: @entity2048 :: ('MESH:D004832', 'Disease') :: ['Absence seizures', 'absence seizures', 'ASs', 'ASs and myoclonias']

entities_list: @entity3148 :: ('MESH:D004831', 'Disease') :: ['myoclonic epilepsy of infancy', 'MEI']

answer: @entity2048 :: (MESH:D004832,Disease) :: ['absence seizures']


abstract: PURPOSE: To assess if @entity2048 ( @entity2048 ) occur in @entity1 with @entity3148 ( @entity3148 ). METHODS: A retrospective chart review was conducted in 37 @entity1 with @entity3148 followed at seven different @entity302 centres in Italy, between 2002 and 2014. To assess the possible occurrence of pure @entity2048 or absences associated with myoclonias, @entity2048 were defined according to the following criteria: (i) a sudden onset and interruption of ongoing activities; (ii) bilateral polyspikes or spike-and-wave (SW) complexes; spike SW complexes at 2-4Hz; (iii) duration of @entity5427 : 3-30seconds. RESULTS: Thirty-seven @entity3148 @entity1 (25 @entity1 and 12 @entity1 ) were identified. Nine @entity1 (24.3%) had a history of simple FS during the first year of life. Ten @entity1 (27%) had a family history of @entity302 , and six @entity1 (16.2%) had a family history of FS. In 7/37 (18.9%) @entity1 , during the occurrence of MSs, a total of nineteen brief @entity2048 were captured by video-EEG recordings. @entity2048 occurred both during a brief cluster of rhythmic MSs than after single @entity2045 . The ictal EEG abnormalities observed in @entity1 with @entity2048 were similar to the ictal EEG patterns associated with only myoclonias. No differences in relation to gender, family history, ictal EEG discharge were found between @entity1 with @entity410 with @entity2048 without @entity2048 . CONCLUSIONS: @entity2048 can occur in approximately 20% of @entity3148 @entity1 and the occurrence of @entity2048 , though not essential to formulate the diagnosis, do not automatically exclude the diagnosis of @entity3148 .

title: Do pure @entity2048 occur in XXXX ? A case series.

answer: @entity3148 :: (MESH:D004831,Disease) :: ['myoclonic epilepsy of infancy']


abstract: UNASSIGNED: Conventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for @entity5 treatment. In this study we have shown antitumor activity of @entity27624 ( @entity27624 ) secreted by @entity1838 . One   g of @entity27624 showed potent antitumor activity when injected into Ehrlich ascites @entity5 in Swiss albino @entity19 . Weekly administration of this dose is able to significantly diminish a large @entity5 volume within 3  weeks and increases the survival rates of cancerous @entity19 . @entity27624 showed apoptotic activity on EAC and other malignant cells. Increased level of pro-apoptotic @entity899 with increased ratio of pro-apoptotic @entity1380 to anti-apoptotic @entity1379 signify that @entity27624 induced apoptogenic signals lead to death of the @entity5 cells. In vivo and ex vivo studies suggest that mitochondrial dependent intrinsic pathway is responsible for this apoptosis. The level of ROS in malignant cells is reported to be higher than the normal healthy cells. @entity27624 induces oxidative stress and increases the level of ROS in malignant cells which is significantly higher than the normal healthy cells. As a result the malignant cells cross the threshold level of ROS for cell survival faster than normal healthy cells. This mechanism causes @entity27624 mediated apoptosis in malignant cells, but normal cells remain unaltered in the same environment. Our study suggests that @entity27624 may be used as a new candidate drug for @entity5 therapy.

title: Hemagglutinin protease secreted by XXXX induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses @entity5 growth in @entity19 model.

entities_list: @entity27624 :: ('MESH:C566273', 'Disease') :: ['hemagglutinin protease', 'HAP']

entities_list: @entity1838 :: ('666', 'Species') :: ['Vibrio cholerae']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'carcinoma (EAC) tumors']

answer: @entity1838 :: (666,Species) :: ['V. cholerae']


abstract: UNASSIGNED: Conventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for @entity5 treatment. In this study we have shown antitumor activity of @entity27624 ( @entity27624 ) secreted by @entity1838 . One   g of @entity27624 showed potent antitumor activity when injected into Ehrlich ascites @entity5 in Swiss albino @entity19 . Weekly administration of this dose is able to significantly diminish a large @entity5 volume within 3  weeks and increases the survival rates of cancerous @entity19 . @entity27624 showed apoptotic activity on EAC and other malignant cells. Increased level of pro-apoptotic @entity899 with increased ratio of pro-apoptotic @entity1380 to anti-apoptotic @entity1379 signify that @entity27624 induced apoptogenic signals lead to death of the @entity5 cells. In vivo and ex vivo studies suggest that mitochondrial dependent intrinsic pathway is responsible for this apoptosis. The level of ROS in malignant cells is reported to be higher than the normal healthy cells. @entity27624 induces oxidative stress and increases the level of ROS in malignant cells which is significantly higher than the normal healthy cells. As a result the malignant cells cross the threshold level of ROS for cell survival faster than normal healthy cells. This mechanism causes @entity27624 mediated apoptosis in malignant cells, but normal cells remain unaltered in the same environment. Our study suggests that @entity27624 may be used as a new candidate drug for @entity5 therapy.

title: Hemagglutinin protease secreted by @entity1838 induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses XXXX growth in @entity19 model.

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: UNASSIGNED: Conventional anticancer therapies are effective but have side effects, so alternative targets are being developed. Bacterial toxins that can kill cells or alter the cellular processes like proliferation, apoptosis and differentiation have been reported for @entity5 treatment. In this study we have shown antitumor activity of @entity27624 ( @entity27624 ) secreted by @entity1838 . One   g of @entity27624 showed potent antitumor activity when injected into Ehrlich ascites @entity5 in Swiss albino @entity19 . Weekly administration of this dose is able to significantly diminish a large @entity5 volume within 3  weeks and increases the survival rates of cancerous @entity19 . @entity27624 showed apoptotic activity on EAC and other malignant cells. Increased level of pro-apoptotic @entity899 with increased ratio of pro-apoptotic @entity1380 to anti-apoptotic @entity1379 signify that @entity27624 induced apoptogenic signals lead to death of the @entity5 cells. In vivo and ex vivo studies suggest that mitochondrial dependent intrinsic pathway is responsible for this apoptosis. The level of ROS in malignant cells is reported to be higher than the normal healthy cells. @entity27624 induces oxidative stress and increases the level of ROS in malignant cells which is significantly higher than the normal healthy cells. As a result the malignant cells cross the threshold level of ROS for cell survival faster than normal healthy cells. This mechanism causes @entity27624 mediated apoptosis in malignant cells, but normal cells remain unaltered in the same environment. Our study suggests that @entity27624 may be used as a new candidate drug for @entity5 therapy.

title: Hemagglutinin protease secreted by @entity1838 induced apoptosis in breast cancer cells by ROS mediated intrinsic pathway and regresses @entity5 growth in XXXX model.

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: Idiopathic @entity1318 is a primary @entity1208 characterized by loss of esophageal peristalsis and insufficient lower esophageal sphincter relaxation in response to deglutition. @entity1 with @entity1318 commonly complain of @entity1282 to solids and liquids, bland regurgitation often unresponsive to an adequate trial of proton pump inhibitor, and @entity662 . @entity353 is present in many, but not all @entity1 . Although the precise etiology is unknown, it is often thought to be either autoimmune, viral immune, or neurodegenerative. The diagnosis is based on history of the disease, barium esophagogram, and esophageal motility testing. Endoscopic assessment of the gastroesophageal junction and @entity356 is necessary to rule out malignancy. Newer diagnostic modalities such as high resolution manometry help in predicting treatment response in @entity1318 based on esophageal pressure topography patterns identifying three phenotypes of @entity1318 (I-III) and outcome studies suggest better treatment response with types I and II compared to type III. Although @entity1318 cannot be permanently cured, excellent outcomes are achieved in over 90 % of @entity1 . Current medical and surgical therapeutic options ( @entity384 , @entity954 , and pharmacologic agents) aim at reducing the LES pressure and facilitating esophageal emptying by gravity and hydrostatic pressure of retained food and liquids. Either graded pneumatic dilatation or laparoscopic surgical myotomy with a partial fundoplication are recommended as initial therapy guided by @entity1 age, gender, preference, and local institutional expertise. The prognosis in @entity1318 @entity1 is excellent. Most @entity1 who are appropriately treated have a normal life expectancy but the disease does recur and the @entity1 may need intermittent treatment.

title: XXXX : a review.

entities_list: @entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['Weight loss']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['pneumatic dilation']

entities_list: @entity1208 :: ('MESH:D004935', 'Disease') :: ['esophageal motor disorder']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['endoscopic and surgical myotomy']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cardia']

answer: @entity1318 :: (MESH:D004931,Disease) :: ['Idiopathic (primary) achalasia']


abstract: BACKGROUND: @entity189 associated fibroblasts (CAFs), an important component of @entity5 microenvironment, are capable of enhancing @entity5 cells invasion and migration through initiation of epithelial-mesenchymal transition (EMT). MRC-5 fibroblasts are one of the CAFs expressing alpha-smooth muscle actin. It is ascertained that medium conditioned by MRC-5 fibroblasts stimulate motility and invasion of @entity0 cells. However, its role in @entity157 ( @entity157 ) is less clear. The aim of our study was to investigate the effect of MRC-5-CM on @entity157 and explore the underlying mechanisms. METHODS AND RESULTS: Using a combination of techniques, the role of MRC-5-CM in @entity157 was evaluated. We determined that MRC-5-CM induced the non-classical EMT in Bel-7402 and MHCC- @entity1 cell lines. Initiation of the non-classical EMT was mainly via quintessential redistribution of a-, b- and y-catenin, @entity8780 , @entity5962 , and @entity6076 , rather than up-regulation of typical EMT-related transcription factors (i.e., @entity4245 , @entity8945 , @entity18075 and @entity18436 ). We also found that MRC-5-CM potentiated both the migration and invasion of Bel-7402 and MHCC- @entity1 cells in mesenchymal movement mode through activation of the a6, b3, b4, b7 integrin/ @entity3818 pathway and upregulation of @entity1476 . The flow cytometric analysis showed that MRC-5-CM induced G1 phase arrest in Bel-7402 cells with a concomitant reduction of S phase cells. In contrast, MRC-5-CM induced S phase arrest in MHCC- @entity1 cells with a concomitant reduction of cells in the G2/M phase. MRC-5-CM also inhibited apoptosis in Bel-7402 cells while inducing apoptosis in MHCC- @entity1 cells. CONCLUSION: Collectively, MRC-5-CM promoted @entity157 cell motility and invasiveness through initiation of the non-classical EMT, including redistribution of a-, b- and y-catenin, @entity8780 , @entity5962 , and @entity6076 , activation of the integrin/ @entity3818 pathway, and upregulation of @entity1476 . Hence, MRC-5-CM exerted distinct roles in Bel-7402 and MHCC- @entity1 cell viability by regulating cyclins, cyclin dependent kinases (CDKs), CDK inhibitors (CKIs), @entity588 family proteins and other unknown mechanosensors.

title: MRC-5 fibroblast-conditioned medium influences multiple pathways regulating invasion, migration, proliferation, and apoptosis in XXXX .

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Carcinoma']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: UNASSIGNED: Mature T-cell @entity706 comprise a group of heterogeneous diseases that vary in clinicopathological features, biological behavior, treatment response, and prognosis. Bone marrow (BM) infiltration is more commonly present in mature T-cell @entity706 compared with their B-cell counterparts and hence important for differential diagnosis. In this study, clinical characteristics and prognostic factors were analyzed in 225 @entity1 with mature T-cell @entity706 treated in a single institution. These included 29 cases of @entity1071 ( @entity1071 , all with BM infiltration) and 196 cases of T-/natural-killer-cell lymphoma (T/NKCL, 56 with BM infiltration and 140 without BM infiltration). The estimated 5-year @entity1349 ( @entity1349 ) rates of @entity1071 and T/NKCL were 96.6% and 37.3%, respectively. @entity1071 @entity1 were less likely to exhibit poor performance status, @entity1442 stage, presence of B symptoms, or abnormal level of serum @entity6393 . With similar pathological characteristics, T/NKCL @entity1 with BM infiltration showed significantly lower response rates and shorter @entity1349 than those without BM infiltration (P = 0.0264 and P < 0.0001, respectively). Multivariate analysis indicated that poor performance status, @entity1442 stage, elevated serum @entity880 dehydrogenase level, and BM involvement were independent unfavorable prognostic factors. The Glasgow Prognostic Score may be more efficient than the International Prognostic Index in predicting disease outcome in T/NKCL. In conclusion, clinical characteristics may be useful in more effectively stratifying @entity1 with mature T-cell @entity706 .

title: Clinical characteristics and prognostic factors of @entity1 with mature T-cell XXXX : a single-institution study of 225 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1071 :: ('MESH:D008232', 'Disease') :: ['T-LPD', 'T-cell lymphoproliferative disorders']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoid malignancies']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity706 :: (MESH:D008223,Disease) :: ['lymphoid malignancies']