abstract: BACKGROUND: Anthropometry is becoming a popular method for diagnostics of @entity66 in pediatric clinical practice. The aim of this study was to assess the growth changes in craniofacial parameters in @entity1 with @entity91 and @entity12832 . METHODS: Inclusion criteria for the study were presence of @entity91 or @entity12832 in a @entity1 with at least three anthropometric evaluations at our department. Studied @entity1 were aged from 1.0 month to 2.5 years with median age at the first and last anthropometric evaluation as 1.83 and 25.27 months, respectively. Further anthropometric results in @entity1 older than 2.5 years were excluded from the study. Statistical significance was tested by the Mann-Whitney test. RESULTS: The studied group consisted of 70.5% male @entity1 . The type of @entity91 was represented by @entity91 in 44.1%, by @entity91 in 45.6% and by @entity6792 in 10.3% of the cases. Cranial index was proven as a suitable parameter for evaluating differences in the trend of growth in @entity91 (p<0.001) and also for evaluating post-operative results. Significance was found in width of the head (p=0.038) for @entity91 and in length of the head for @entity91 (p=0.001) in surgically treated @entity1 . Trend of cranial growth in operated @entity1 copied the curve of the norm but in higher or lower values which depends on the type of prematurely closed suture. CONCLUSION: Longitudinal anthropometric follow-up is an objective and measurable method that can accurately non-invasively and non-expensively assess skull growth in pediatric @entity1 with @entity85 .

title: Anthropometry of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity12832 :: ('MESH:D049068', 'Disease') :: ['positional plagiocephaly']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['various diseases']

entities_list: @entity6792 :: ('MESH:C537369', 'Disease') :: ['coronal craniosynostosis']

entities_list: @entity91 :: ('MESH:D003398', 'Disease') :: ['craniostenosis', 'scaphocephaly', 'craniosynostosis', 'trigonocephaly']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['cranial deformity']

answer: @entity91 :: (MESH:D003398,Disease) :: ['craniosynostosis']


abstract: UNASSIGNED: Neural stem cells proliferate and differentiate into neurons and glial cells, being responsible for embryonic and postnatal development of the central nervous system (CNS) as well as for regeneration in the adult brain. These cells also play a key role in maintaining the physiological integrity of the CNS in face of @entity66 . The previous study has demonstrated that @entity1812 (BK) treatment simultaneously induces neuronal enrichment (indicating that BK contributes to neurogenesis) and reduced proliferation rates during in vitro differentiation of @entity35 embryonic telencephalon neural precursor cells (NPCs). Here, we provide a mechanism for the unresolved question whether (i) the low rate of proliferation is owed to enhanced neurogenesis or, conversely, (ii) the alteration of the population ratio could result from low proliferation of NPCs and glial cells. In agreement with the previous study, BK promoted neuron-specific b3-tubulin and @entity7001 expression in differentiating embryonic @entity19 neurospheres, whereas glial protein expression and global proliferation rates decreased. Furthermore, BK augmented the global frequency of cells in G0 -phase of cell cycle after differentiation. Heterogeneous cell populations were observed at this stage, including neurons that always remaining a quiescent state (G0 -phase). It is noteworthy that BK did not interfere with proliferation of any particular cell type, evidenced by coimmunostaining for nestin, b3-tubulin, glial fibrillary acidic protein (GFAP), and @entity10080 ( @entity10081 ). Thus, we conclude that neuronal enrichment is owing only to the fostering of neurogenesis, and that the low proliferation rate on the seventh day of differentiation is a consequence and not the cause of BK-induced neuronal enrichment.    2015 International Society for Advancement of Cytometry.

title: XXXX -induced inhibition of proliferation rate during neurosphere differentiation: Consequence or cause of neuronal enrichment?

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['injury or disease']

entities_list: @entity10080 :: ('MESH:C031086', 'Chemical') :: ["5-ethynyl-2'-deoxyuridine"]

entities_list: @entity1812 :: ('MESH:D001920', 'Chemical') :: ['bradykinin']

answer: @entity1812 :: (MESH:D001920,Chemical) :: ['Bradykinin']


abstract: BACKGROUND: Good clinical results have been reported for both surgical and conservative treatment of rotator cuff tears. The primary aim of this randomized controlled trial was to compare functional and radiologic improvement after surgical and conservative treatment of @entity717 cuff tears. METHODS: We conducted a randomized controlled trial that included 56 @entity1 with a degenerative full-thickness rotator cuff tear between January 2009 and December 2012; 31 @entity1 were treated conservatively, and rotator cuff repair was performed in 25 @entity1 . Outcome measures, including the Constant-Murley score (CMS), visual analog scale (VAS) @entity158 and @entity227 scores, were assessed preoperatively and after 6  weeks and 3, 6, and 12  months. Magnetic resonance imaging was performed preoperatively and at 12  months postoperatively. RESULTS: At 12  months postoperatively, the mean CMS was 81.9 (standard deviation [SD], 15.6) in the surgery group vs 73.7 (SD, 18.4) in the conservative group (P  =  .08). VAS @entity158 (P  =  .04) and @entity227 (P  =  .02) were significantly lower in the surgery group at the 12-month follow-up. A subgroup analysis showed postoperative CMS results were significantly better in surgically treated @entity1 without a retear compared with conservatively treated @entity1 (88.5 [SD, 6.2] vs 73.7 [SD, 18.4]). CONCLUSION: In our population of @entity1 with @entity717 cuff tears who were randomly treated by surgery or conservative protocol, we did not observe differences in functional outcome as measured with the CMS 1 year after treatment. However, significant differences in @entity158 and disabilities were observed in favor of surgical treatment. The best outcomes in function and @entity158 were seen in @entity1 with an intact rotator cuff postoperatively.

title: Comparing surgical repair with conservative treatment for XXXX cuff tears: a  randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['degenerative rotator']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['VAS disability']

answer: @entity717 :: (MESH:D009069,Disease) :: ['degenerative rotator']


abstract: UNASSIGNED: This study examined how a maternal @entity1386 ( @entity1386 ) during lactation and exposure of offspring to isolation stress influence the susceptibility of offspring to the development of @entity28 . C57BL/6J @entity19 were fed a commercial diet (CD) during pregnancy and a CD or @entity1386 during lactation. Male offspring were weaned at three weeks of age, fed a CD until seven weeks of age, and fed a CD or @entity1386 until 11 weeks of age. Offspring were housed alone (isolation stress) or at six per cage (ordinary circumstances). Thus, offspring were assigned to one of eight groups: dams fed a CD or @entity1386 during lactation and offspring fed a CD or @entity1386 and housed under ordinary circumstances or isolation stress. Serum @entity2819 level was significantly elevated by isolation stress. High-fat feeding of offspring reduced their serum @entity2819 level, which was significantly elevated by a maternal @entity1386 . A maternal @entity1386 and isolation stress had combined effects in elevating the serum @entity2819 level. These findings suggest that a maternal @entity1386 during lactation enhances the stress sensitivity of offspring. White adipose tissue weights were significantly increased by a maternal @entity1386 and isolation stress and by their combination. In addition, significant adipocyte @entity1184 was induced by a maternal @entity1386 and isolation stress and exacerbated by their combination. Thus, a maternal @entity1386 and isolation stress promote visceral fat accumulation and adipocyte @entity1184 , accelerating the progression of @entity28 through their combined effects. The mechanism may involve enhanced @entity844 synthesis and lipid influx from blood into adipose tissue. These findings demonstrate that a maternal @entity1386 during lactation may increase the susceptibility of offspring to the development of stress-induced @entity28 .

title: High Dietary Fat Intake during Lactation Promotes the Development of Social Stress-Induced XXXX in the Offspring of @entity19 .

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity2819 :: ('MESH:D003345', 'Chemical') :: ['corticosterone']

entities_list: @entity1386 :: ('MESH:D018205', 'Disease') :: ['HD', 'high-fat diet']

answer: @entity28 :: (MESH:D009765,Disease) :: ['Obesity']


abstract: UNASSIGNED: This study examined how a maternal @entity1386 ( @entity1386 ) during lactation and exposure of offspring to isolation stress influence the susceptibility of offspring to the development of @entity28 . C57BL/6J @entity19 were fed a commercial diet (CD) during pregnancy and a CD or @entity1386 during lactation. Male offspring were weaned at three weeks of age, fed a CD until seven weeks of age, and fed a CD or @entity1386 until 11 weeks of age. Offspring were housed alone (isolation stress) or at six per cage (ordinary circumstances). Thus, offspring were assigned to one of eight groups: dams fed a CD or @entity1386 during lactation and offspring fed a CD or @entity1386 and housed under ordinary circumstances or isolation stress. Serum @entity2819 level was significantly elevated by isolation stress. High-fat feeding of offspring reduced their serum @entity2819 level, which was significantly elevated by a maternal @entity1386 . A maternal @entity1386 and isolation stress had combined effects in elevating the serum @entity2819 level. These findings suggest that a maternal @entity1386 during lactation enhances the stress sensitivity of offspring. White adipose tissue weights were significantly increased by a maternal @entity1386 and isolation stress and by their combination. In addition, significant adipocyte @entity1184 was induced by a maternal @entity1386 and isolation stress and exacerbated by their combination. Thus, a maternal @entity1386 and isolation stress promote visceral fat accumulation and adipocyte @entity1184 , accelerating the progression of @entity28 through their combined effects. The mechanism may involve enhanced @entity844 synthesis and lipid influx from blood into adipose tissue. These findings demonstrate that a maternal @entity1386 during lactation may increase the susceptibility of offspring to the development of stress-induced @entity28 .

title: High Dietary Fat Intake during Lactation Promotes the Development of Social Stress-Induced @entity28 in the Offspring of XXXX .

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: UNASSIGNED: This study investigated whether @entity2204 ( @entity2204 ) was associated with the presence of @entity1 herpes virus ( @entity780 B in @entity1315 ( @entity1315 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity2204 polymorphism in 46 @entity1 with @entity1315 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity780 B DNA and immunohistochemistry (IHC) for @entity780 B protein. Viral DNA load was significantly increased in @entity1315 @entity1 with @entity780 B(+)/ @entity2204 compared with those with @entity780 B(+)/non- @entity2204 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity780 B proteins G116/64/54, P98 and U94 in @entity1 with @entity780 B(+)/ @entity2204 than @entity780 B(+)/non- @entity2204 (p=0.009, 0.035 and 0.009, respectively). @entity1 with @entity780 B(+)/ @entity2204 showed higher @entity410 frequency than those with @entity780 B(+)/non- @entity2204 (p=0.005). There was no significant difference of @entity2204 alleles between @entity1315 with and without @entity780 B (p=0.115). @entity2204 was not associated with initial infection of @entity780 B in @entity1315 . However, @entity2204 may facilitate @entity780 B reactivation, DNA replication, virus protein expression and increase @entity410 frequency in @entity1315 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity2204 and @entity780 B.

title: @entity2204 may increase viral load and XXXX frequency in @entity1315 @entity1 with positive @entity1 herpes virus 6B.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'human', 'patients']

entities_list: @entity2204 :: ('348', 'Gene') :: ['ApoE4', 'apolipoprotein 4', 'ApoE']

entities_list: @entity1315 :: ('MESH:D004833', 'Disease') :: ['MTLE', 'mesial temporal lobe epilepsy']

answer: @entity410 :: (MESH:D012640,Disease) :: ['seizure']


abstract: UNASSIGNED: This study investigated whether @entity2204 ( @entity2204 ) was associated with the presence of @entity1 herpes virus ( @entity780 B in @entity1315 ( @entity1315 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity2204 polymorphism in 46 @entity1 with @entity1315 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity780 B DNA and immunohistochemistry (IHC) for @entity780 B protein. Viral DNA load was significantly increased in @entity1315 @entity1 with @entity780 B(+)/ @entity2204 compared with those with @entity780 B(+)/non- @entity2204 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity780 B proteins G116/64/54, P98 and U94 in @entity1 with @entity780 B(+)/ @entity2204 than @entity780 B(+)/non- @entity2204 (p=0.009, 0.035 and 0.009, respectively). @entity1 with @entity780 B(+)/ @entity2204 showed higher @entity410 frequency than those with @entity780 B(+)/non- @entity2204 (p=0.005). There was no significant difference of @entity2204 alleles between @entity1315 with and without @entity780 B (p=0.115). @entity2204 was not associated with initial infection of @entity780 B in @entity1315 . However, @entity2204 may facilitate @entity780 B reactivation, DNA replication, virus protein expression and increase @entity410 frequency in @entity1315 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity2204 and @entity780 B.

title: @entity2204 may increase viral load and @entity410 frequency in XXXX @entity1 with positive @entity1 herpes virus 6B.

answer: @entity1315 :: (MESH:D004833,Disease) :: ['mesial temporal lobe epilepsy']


abstract: UNASSIGNED: This study investigated whether @entity2204 ( @entity2204 ) was associated with the presence of @entity1 herpes virus ( @entity780 B in @entity1315 ( @entity1315 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity2204 polymorphism in 46 @entity1 with @entity1315 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity780 B DNA and immunohistochemistry (IHC) for @entity780 B protein. Viral DNA load was significantly increased in @entity1315 @entity1 with @entity780 B(+)/ @entity2204 compared with those with @entity780 B(+)/non- @entity2204 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity780 B proteins G116/64/54, P98 and U94 in @entity1 with @entity780 B(+)/ @entity2204 than @entity780 B(+)/non- @entity2204 (p=0.009, 0.035 and 0.009, respectively). @entity1 with @entity780 B(+)/ @entity2204 showed higher @entity410 frequency than those with @entity780 B(+)/non- @entity2204 (p=0.005). There was no significant difference of @entity2204 alleles between @entity1315 with and without @entity780 B (p=0.115). @entity2204 was not associated with initial infection of @entity780 B in @entity1315 . However, @entity2204 may facilitate @entity780 B reactivation, DNA replication, virus protein expression and increase @entity410 frequency in @entity1315 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity2204 and @entity780 B.

title: XXXX may increase viral load and @entity410 frequency in @entity1315 @entity1 with positive @entity1 herpes virus 6B.

answer: @entity2204 :: (348,Gene) :: ['Apolipoprotein 4']


abstract: UNASSIGNED: This study investigated whether @entity2204 ( @entity2204 ) was associated with the presence of @entity1 herpes virus ( @entity780 B in @entity1315 ( @entity1315 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity2204 polymorphism in 46 @entity1 with @entity1315 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity780 B DNA and immunohistochemistry (IHC) for @entity780 B protein. Viral DNA load was significantly increased in @entity1315 @entity1 with @entity780 B(+)/ @entity2204 compared with those with @entity780 B(+)/non- @entity2204 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity780 B proteins G116/64/54, P98 and U94 in @entity1 with @entity780 B(+)/ @entity2204 than @entity780 B(+)/non- @entity2204 (p=0.009, 0.035 and 0.009, respectively). @entity1 with @entity780 B(+)/ @entity2204 showed higher @entity410 frequency than those with @entity780 B(+)/non- @entity2204 (p=0.005). There was no significant difference of @entity2204 alleles between @entity1315 with and without @entity780 B (p=0.115). @entity2204 was not associated with initial infection of @entity780 B in @entity1315 . However, @entity2204 may facilitate @entity780 B reactivation, DNA replication, virus protein expression and increase @entity410 frequency in @entity1315 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity2204 and @entity780 B.

title: @entity2204 may increase viral load and @entity410 frequency in @entity1315 XXXX with positive @entity1 herpes virus 6B.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: This study investigated whether @entity2204 ( @entity2204 ) was associated with the presence of @entity1 herpes virus ( @entity780 B in @entity1315 ( @entity1315 ). Polymerase chain reaction-restricted fragment length polymorphism (PCR-RFLP) was used to determine @entity2204 polymorphism in 46 @entity1 with @entity1315 and 19 controls. Nested PCR and real-time PCR were applied to determine @entity780 B DNA and immunohistochemistry (IHC) for @entity780 B protein. Viral DNA load was significantly increased in @entity1315 @entity1 with @entity780 B(+)/ @entity2204 compared with those with @entity780 B(+)/non- @entity2204 (p=0.031). Semi-quantitative analysis of IHC showed significantly increased number of positive cells for @entity780 B proteins G116/64/54, P98 and U94 in @entity1 with @entity780 B(+)/ @entity2204 than @entity780 B(+)/non- @entity2204 (p=0.009, 0.035 and 0.009, respectively). @entity1 with @entity780 B(+)/ @entity2204 showed higher @entity410 frequency than those with @entity780 B(+)/non- @entity2204 (p=0.005). There was no significant difference of @entity2204 alleles between @entity1315 with and without @entity780 B (p=0.115). @entity2204 was not associated with initial infection of @entity780 B in @entity1315 . However, @entity2204 may facilitate @entity780 B reactivation, DNA replication, virus protein expression and increase @entity410 frequency in @entity1315 . Further investigations are needed to understand the biomolecular mechanism underlying interaction between @entity2204 and @entity780 B.

title: @entity2204 may increase viral load and @entity410 frequency in @entity1315 @entity1 with positive XXXX herpes virus 6B.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: Pelvic and paraortic lymph nodal regions are frequent sites of relapse in @entity1 with @entity1204 who have not undergone adjuvant external beam radiation. We investigated outcomes after definitive management of nodal relapses of @entity1204 with intensity modulated radiation therapy (IMRT). METHODS: Between 2002-2012, 38 @entity1 with @entity1204 who had no prior external beam radiation were treated definitively using IMRT for regionally confined pelvic or paraortic nodal recurrences. Thirteen (34%) had chemotherapy prior to radiation, and 21 (55%) received concurrent chemotherapy. The nodal basins were typically treated to 45-50Gy, with a boost to the gross @entity5 to a median total of 64.7Gy (range 59-73Gy). RESULTS: The median overall survival from date of recurrence was 46.1months and the 2-year survival was 71%. @entity1 who received concurrent chemotherapy had a significantly longer median survival (61.9months versus 28.7months, p=0.034). In-field failures were more frequent in @entity1 who received chemotherapy prior to radiation, had a shorter recurrence-free interval, received a lower radiation dose, and had higher @entity5 grade. Three @entity1 (8%) experienced grade 3-4 late gastrointestinal (GI) @entity137 . CONCLUSIONS: Long-term survival can be achieved in @entity1 with nodal recurrences of @entity1204 . The use of concurrent chemotherapy and dose escalation with IMRT as feasible may improve survival for @entity1 with isolated nodal recurrences of @entity1204 .

title: Management of nodal recurrences of XXXX with IMRT.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']


abstract: BACKGROUND: Pathological studies have suggested that @entity1187 ( @entity1187 ) may be caused by culprit lesions with intact fibrous cap (IFC), including @entity2681 . This study sought to evaluate the morphological features and clinical outcomes of @entity1 with @entity1187 caused by lesions with IFC. METHODS: A total of 318 @entity1 with @entity1187 who underwent optical coherence tomography (OCT) of a culprit lesion were investigated. The culprit lesions were categorized as follows: those with @entity397 (PR group), those with an IFC (IFC group), and those with a massive @entity715 precluding plaque visualization (MT group). Intravascular ultrasound (IVUS) was performed in 297 @entity1 . Clinical follow-up data were collected regarding adverse @entity299 , including death, @entity583 , revascularization, and @entity712 requiring hospitalization. RESULTS: Culprit lesions were categorized into 141 RPs, 131 IFCs, and 46 MTs. IFC group exhibited a smaller remodeling index and less frequently attenuated plaques on IVUS. Three hundred and seven @entity1 (96.5%) were followed for a median follow-up duration of 576days. Adverse @entity299 were observed in 93 @entity1 (30.3%). Kaplan-Meier analysis demonstrated a significantly lower event rate in IFC group compared with the @entity6391 and MT groups. Cox proportional hazard analysis demonstrated that an IFC and multivessel disease were independent predictors of adverse events [hazard ratio 0.57, 95% confidence interval (CI) 0.33-0.98, p=0.043 and hazard ratio 1.72, 95% CI 1.09-2.73, p=0.021]. CONCLUSIONS: Culprit lesions with IFC showed smaller remodeling indices by IVUS, and were associated with better long-term prognosis compared with those with @entity397 .

title: Plaque morphologies and the clinical prognosis of XXXX caused by lesions with intact fibrous cap diagnosed by optical coherence tomography.

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['ACS', 'acute coronary syndrome']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity2681 :: ('MESH:D014077', 'Disease') :: ['plaque erosions']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['plaque rupture']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

answer: @entity1187 :: (MESH:D054058,Disease) :: ['acute coronary syndrome']


abstract: BACKGROUND: Greater body mass index (BMI), a measure of overall adiposity, is associated with a higher risk of @entity0 . The role of central adiposity, often measured by waist circumference, is less well understood, especially among premenopausal @entity1 . The objective of the current study was to examine multiple measures of adiposity in relation to @entity0 in a prospective cohort study. METHODS: A total of 50,884 Sister Study cohort @entity1 aged 35 to 74 years were enrolled from 2003 through 2009. Inclusion criteria for the cohort included having a sister previously diagnosed with @entity0 . Trained study personnel measured height, weight, and waist and hip circumference during a home visit and study @entity1 completed a detailed questionnaire. Using Cox regression analysis, we estimated multivariable hazard ratios (HRs) and 95% confidence intervals (95% CIs) for @entity0 risk associated with adiposity measurements, considering @entity5 subtype and menopausal status. RESULTS: In total, 2009 @entity0 were diagnosed during follow-up (mean   =   5.4 years). Weight, BMI, waist circumference, and waist-to-hip ratio were found to be positively associated with overall @entity0 risk and HRs were greater among postmenopausal @entity1 , those with hormonally responsive @entity5 , and @entity1 who were not currently using postmenopausal hormones. In models that adjusted for BMI, waist circumference associations persisted among both postmenopausal @entity1 (81-88 cm vs  <=80 cm: HR   =   1.16 [95% CI 1.01-1.35] and >88 cm vs  <=80 cm: HR   =   1.30 [95% CI 1.10-1.54]) and premenopausal @entity1 (81-88 cm vs  <=80 cm: HR   =   1.56 [95% CI 1.19-2.04] and >88 cm vs  <=80 cm: HR   =   1.30 [95% CI 0.91-1.87]). CONCLUSIONS: Findings from this large, prospective study with examiner-measured body size indicate that waist circumference is independently and positively associated with both premenopausal and @entity0 risk. @entity5 2015;121:3700-3708.    2015 American @entity5 Society.

title: Overall and central adiposity and XXXX risk in the sister study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer', 'tumors']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['postmenopausal breast cancer', 'breast cancers', 'breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: UNASSIGNED: @entity8863 -immobilized magnetic @entity71415 (mPHEMAH) nanoparticles were prepared by surfactant-free emulsion polymerization for cytochrome C (cyt C) purification from @entity35 liver. Elemental analysis, atomic force microscopy, zeta sizer, and vibrating sample magnetometer were used to characterize mPHEMAH nanoparticles. In addition to these characterization steps, surface area, average particle size, and size distribution of mPHEMAH nanoparticles were determined. Quantity of immobilized @entity8863 was measured using atomic absorption spectrophotometry. @entity71416 and @entity8863 content of mPHEMAH nanoparticles were 0.18 mmol/g polymer and 0.11 mmol/g polymer, respectively. Specific surface area of @entity8863 -immobilized mPHEMAH nanoparticles was 1180 m(2) /g. Effect of initial cyt C concentration, pH, temperature, and ionic strength on cyt C adsorption onto @entity8863 -immobilized mPHEMAH nanoparticles was investigated. Maximum cyt C adsorption capacity of @entity8863 -immobilized mPHEMAH nanoparticles was 311.9 mg/g polymer. Maximum adsorption was obtained at pH 8.0 and 4    C. @entity8863 -immobilized mPHEMAH nanoparticles were used ten times with 4.1% decrease in adsorption capacity. In the last stage, @entity8863 -immobilized mPHEMAH nanoparticles were used to purify cyt C from @entity35 liver tissue, and the purity of desorbed fractions was controlled by @entity214 -PAGE.

title: Metal-immobilized magnetic nanoparticles for cytochrome C purification from XXXX liver.

entities_list: @entity71416 :: ('MESH:C491950', 'Chemical') :: ['N-Methacryloyl-(l)-histidinemethylester']

entities_list: @entity71415 :: ('MESH:C579323', 'Chemical') :: ['poly(hydroxyethylmethacrylate-N-methacryloyl-(l)-histidinemethylester)']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND: Lung contusion (LC) followed by @entity548 ( @entity548 ) causes persistent bone marrow (BM) dysfunction lasting up to 7 d after injury. Mesenchymal stem cells (MSCs) are multipotent cells that can hasten healing and exert protective immunomodulatory effects. We hypothesize that MSCs can attenuate BM dysfunction after combined LCHS. MATERIALS AND METHODS: Male @entity35 (n = 5-6 per group) underwent LC plus 45 min of @entity548 (mean arterial pressure of 30-35). Allogeneic MSCs (5 * 10(6) cells) were injected intravenously after resuscitation. At 7 d, BM was analyzed for cellularity and growth of hematopoietic progenitor cell (HPC) colonies (colony-forming unit-erythroid; burst-forming unit-erythroid; and colony-forming unit-granulocyte, erythrocyte, monocyte, megakaryocyte). Flow cytometry measured %HPCs in peripheral blood; plasma @entity7420 ( @entity7420 ) levels were measured via enzyme-linked immunosorbent assay. Data were analyzed by one-way analysis of variance followed by the Tukey multiple comparison test. RESULTS: As previously shown, at 7 d, LCHS resulted in 22%, 30%, and 24% decreases in colony-forming unit-granulocyte, erythrocyte, monocyte, megakaryocyte, burst-forming unit-erythroid, and colony-forming unit-erythroid colony growth, respectively, versus naive. Treatment with MSCs returned all BM parameters to naive levels. There was no difference in %HPCs in peripheral blood between groups; however, @entity7420 remained increased up to 7 d after LCHS. MSCs returned @entity7420 to naive levels. Plasma from animals receiving MSCs was not suppressive to the BM. CONCLUSIONS: One week after injury, the persistent BM dysfunction observed in animals undergoing LCHS is reversed by treatment with MSCs with an associated return of plasma @entity7420 levels to normal. Plasma from animals undergoing LCHS plus MSCs was not suppressive to BM cells in vitro. Treatment with MSCs after injury and shock reverses BM suppression and returns plasma @entity7420 levels to normal.

title: Mesenchymal stem cells reverse trauma and XXXX -induced bone marrow dysfunction.

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity7420 :: ('25610(Tax:10116)', 'Gene') :: ['granulocyte colony-stimulating factor', 'G-CSF']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic shock', 'HS']

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhagic shock']


abstract: UNASSIGNED: The focus of this research is in the definition of programmable expert Personal Health Systems (PHS) to monitor @entity1 affected by @entity102 using agent oriented programming and mobile computing to represent the interactions happening amongst the components of the system. The paper also discusses issues of knowledge representation within the medical domain when dealing with temporal patterns concerning the physiological values of the @entity1 . In the presented agent based PHS the doctors can personalize for each @entity1 monitoring rules that can be defined in a graphical way. Furthermore, to achieve better scalability, the computations for monitoring the @entity1 are distributed among their devices rather than being performed in a centralized server. The system is evaluated using data of 21 @entity6 @entity1 to detect temporal patterns according to a set of monitoring rules defined. The system's scalability is evaluated by comparing it with a centralized approach. The evaluation concerning the detection of temporal patterns highlights the system's ability to monitor chronic @entity1 affected by @entity6 . Regarding the scalability, the results show the fact that an approach exploiting the use of mobile computing is more scalable than a centralized approach. Therefore, more likely to satisfy the needs of next generation PHSs. PHSs are becoming an adopted technology to deal with the surge of @entity1 affected by @entity102 . This paper discusses architectural choices to make an agent based PHS more scalable by using a distributed mobile computing approach. It also discusses how to model the medical knowledge in the PHS in such a way that it is modifiable at run time. The evaluation highlights the necessity of distributing the reasoning to the mobile part of the system and that modifiable rules are able to deal with the change in lifestyle of the @entity1 affected by @entity102 .

title: Processing XXXX Composite Events in MAGPIE.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic illnesses', 'chronic diseases']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes Mellitus']


abstract: OBJECTIVE: To evaluate the trans and @entity260 and surgical results of Tension Free Vaginal Tape Obturator System (TVT-O) for stress @entity322 treatment in Angeles del Pedregal Hospital in a five year follow-up. MATERIAL AND METHODS: A retrospective, descriptive case series study with 67 @entity1 was conducted in the Urogynecology Clinic in Hospital Angeles del Pedregal between January 2006 and December 2012. @entity1 with stress @entity322 treated by TVT-O were included. Complications and efficacy of the treatment are described in a 5 year follow-up. RESULTS: 29.9% of the @entity1 had the urodynamic diagnosis of @entity3142 . The 55.2% of them had no other procedure done than the TVT-O. No transoperative complications were observed, but in the postoperative period, 2 (3.%) @entity1 had urinary retention secondary to overcorrected urethra and 1 (1.5%) with intense groin @entity158 . Two cases (3%) presented tape erosion to vagina at 18 months follow-up, with less than 5mm exposure areas. Average follow-up time was 2 years. 46.26% of @entity1 completed a 5 years follow-up. Subjective and objective cures were obtained in all 67 @entity1 . CONCLUSIONS: Tension free @entity10193 is a minimally invasive procedure that has excellent results (above 95%) in the treatment of stress @entity322 with a low rate of complications. Currently, it can be considered as the gold standard surgical treatment for stress @entity322 .

title: [Stress XXXX treatment with modified technique tension-free vaginal tape obturator].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity10193 :: ('MESH:D006553', 'Disease') :: ['vaginal tape obturator system']

entities_list: @entity3142 :: ('MESH:D014550', 'Disease') :: ['stress incontinence']

answer: @entity322 :: (MESH:D014549,Disease) :: ['urinary incontinence']


abstract: INTRODUCTION: Caloric restriction is the only well-documented nutritional intervention prolonging the life of mammals. This method modifies the lipid levels in blood, controlling @entity28 and delaying the onset of many medical conditions associated with @entity209 . The aim of the study was to carry out a comparative analysis of lipid profile in @entity1 on Mediterranean or CRON (Caloric Restriction with Optimal Nutrition) diets, before and after six weeks of dieting. MATERIAL AND METHODS: The following parameters were compared: total @entity165 , total lipids, @entity1674 , LDL @entity165 , HDL @entity165 , and BMI. Additionally, we measured the levels of insulin, HOMA score, and anthropometric parameters. The comparative analysis demonstrated a statistically significant correlation between mild caloric restriction and blood lipid profile. Results from studies on @entity1 who underwent six-week dietetic intervention indicated statistically significant changes in biochemical parameters due to caloric restrictions. Such changes were not found in subjects following the Mediterranean diet. The greatest decrease in the blood level of @entity1674 was found in subjects on the CRON diet, LDL @entity165 , total @entity165 and total lipid levels also decreased. No significant changes if biochemical parameters were found in @entity1 on the Mediterranean diet. CONCLUSIONS: A comparative analysis of all parameters demonstrated that the use of mild caloric restrictions with ensured supply of all necessary nutrients seems to be the most effective solution for reducing fatty tissue.

title: [CHANGES IN BODY MASS AND BLOOD LIPID LEVELS IN XXXX UNDERGOING CALORIC RESTRICTION].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['PATIENTS']


abstract: UNASSIGNED: Objective. To evaluate efficacy and safety of injectable extended-release naltrexone (XR-NTX, Vivitrol), an opioid receptor antagonist, in the treatment of @entity4784 , we carried out a 1-year open-label extension study. Material and methods. The study followed the initial 6-month randomized, double-blind, PBO-controlled investigation of XR-NTX, used in dose 380 mg, as a treatment for @entity4784 . The study was conducted at 13 clinical sites in Russia. The main measurements were monthly urine samples (efficacy) and adverse events (safety). Results and   onclusion. The open-label extension included 114 @entity1 (67 continued on XR-NTX and 47 switched from placebo). Overall, 62.3% (95% CI: 52.7%, 71.2%) of @entity1 completed the extension. Urine testing revealed that 50.9% (41.5%, 60.4%) were abstinent from opioids at all assessments during the 1-year open-label phase. Adverse events were reported by 21.1% of @entity1 . Elevations in liver function tests occurred in 16.7% of @entity1 . No severe adverse events were reported. The data obtained demonstrate the long-term safety and efficacy of XR-NTX in opioid dependent @entity1 .

title: [Injectable extended-release naltrexone for XXXX : an open label study of long-term safety and efficacy.]

entities_list: @entity4784 :: ('MESH:D009293', 'Disease') :: ['opioid dependence']

answer: @entity4784 :: (MESH:D009293,Disease) :: ['opioid dependence']


abstract: UNASSIGNED: Objective. To analyze @entity302 aggravation associated with antiepileptic drugs (AED) in adult @entity1 . Material and methods. We examined 1407 @entity1 aged 18-89 years. Different patterns of @entity410 aggravation were identified in 103 @entity1 . Results. Aggravated @entity410 due the generic substitution were found in 32 @entity1 . First was topiramate (TPM) (n=12), followed by valproates (VPA) (n=8), carbamazepine (CBZ) (n=5), lamotrigine (LTG) (n=1) and levetiracetam (LEV) (n=1). @entity1 with @entity3762 ( @entity3762 ) suffered aggravation with CBZ in 17 cases, VPA - in 6, TPM - in 6, LTG - in 1 and LEV - in 1. CBZ aggravated absences in @entity1 with @entity2048 ( @entity2048 ) were found in 5 cases of 17 (29.4%), with @entity2048 ( @entity2048 ) - in 1 of 24 (4.2%), absences and @entity2045 in @entity3149 ( @entity3149 ) - in 9 of 47 (19.1%), absences with eyelid @entity2045 (Jeavons syndrome) - in 2 of 11 (18.2%). @entity410 aggravations with different AEDs were observed in 13 @entity1 . This pattern of aggravation was associated with resistant @entity302 and poor prognosis. @entity410 aggravation due to increasing the dose of AEDs was found in 10 cases and associated with resistant @entity302 and poor outcome. "True" aggravation was associated with CBZ in 34 @entity1 , including 16 @entity3762 @entity1 , with TPM - in 13, VPA - 5, LTG - 5, LEV - 2 and with clonazepam in 1 @entity1 . Most often @entity410 aggravation was associated with CBZ in @entity3762 @entity1 (8.3%), and with LTG, TPM and CBZ in @entity1 with other @entity302 (non @entity3762 ): 4.9%, 4% and 3.7%, respectively. Conclusions. Different AEDs can cause aggravation. @entity410 aggravation after generic substitution was characteristic of TPM most frequently. @entity410 aggravation with different AEDs and due to increasing the dose of AEDs was associated with poor outcome. In all cases, @entity410 aggravation was more frequently caused by LTG (4.7%), CBZ (3.7%) and TPM (3.3%). To reduce the risk of aggravation, slow AEDs titration and keeping a diary of @entity410 are required.

title: [Antiepileptic drugs and XXXX aggravation.]

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'Seizures', 'seizures', 'Seizure']

entities_list: @entity2045 :: ('MESH:D009207', 'Disease') :: ['myoclonus', 'myoclonic jerks']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic seizure', 'epilepsy', 'epileptic syndromes']

entities_list: @entity2048 :: ('MESH:D004832', 'Disease') :: ['CAE', 'childhood absence epilepsy', 'JAE', 'juvenile absence epilepsy']

entities_list: @entity3149 :: ('MESH:D020190', 'Disease') :: ['juvenile myoclonic epilepsy', 'JME']

entities_list: @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic generalized epilepsies', 'IGE']

answer: @entity410 :: (MESH:D012640,Disease) :: ['seizure']


abstract: BACKGROUND: The onset of winter of 2014-2015 saw an alarming spurt in @entity683 A (H1N1) pdm 09 leading to a significant mortality. Rajasthan was one of the foremost affected state bearing the frontal attack in which majority of @entity204 occurred early and in the young. OBJECTIVE: To sketch out the mortality profile with respect to demographic and clinical progression with an aim to identify the groups, this virus conspicuously picked up with a perspective to control some of the avoidable factors. METHODS: We analyzed the epidemiological data in 76 RT-PCR confirmed @entity204 of H1N1 @entity1 that occurred between 1st January 2015 and 28 February 2015 over a period of 59 days at SMS Medical College Hospital, Jaipur. RESULTS: A total of 412 @entity1 got hospitalized during two months period from 1st January 2015 to 28th February 2015, out of which 76 fatal cases presenting with category C symptoms along with radiological evidence of @entity55 were analyzed. 48.6% @entity204 occurred in the 18-40 years of age group. The mean age being 44.01    15.07 years. Females had a marginally increased mortality rate (F: M-1.23:1). The mean time of onset of symptoms to hospitalization was 6.79    4.63 days. Fifty-one (67.1% 0) @entity1 were from urban areas, whereas 25 (32.89%) belonged to rural areas. Only 7.83% @entity1 presented within 24 - 48 hours whereas 46% presented within 5 days of onset of symptoms. 66.9% succumbed within 5 days of hospitalization, despite of starting @entity684 in a dose of 150 mg/bd on the day of admission. 64.5% had predisposing risk factors. @entity55 was observed in all the 76 @entity1 , @entity295 in 21.12%, @entity881 in 30.26% and AKI in 9.21%. CONCLUSIONS: The in-hospital mortality of 17.79% despite of starting @entity684 has raised concern about identifying the so called "Rapid Progressors" [66.9% succumbing within 5 days of hospitalization]. As a corollary of this analysis the authors are of the opinion that a rejig of the existing guidelines to identify and treat @entity683 like illness be made available at the national level. What factors promote rapid progression especially in a group without any predisposing risk condition should form the focus of future studies. As risk group individuals formed a major chunk of @entity204 , the need to vaccinate this group should form a scaffold on which future directions and interventions have to be built up to combat the morbidity and mortality.

title: Profiling the Mortality due to XXXX (H1N1) pdm09 at a Tertiary Care Hospital in Jaipur during the Current Season--January _ February 2015.

entities_list: @entity684 :: ('MESH:D053139', 'Chemical') :: ['Oseltamivir']

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['septicemia']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['Bilateral pneumonia', 'bilateral pneumonia']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza']

answer: @entity683 :: (MESH:D007251,Disease) :: ['Influenza A']


abstract: @entity11950 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity5 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity1778 cells growth, migration, and the mechanisms underlying the anti- @entity5 activities of GA. @entity98 test was used to detect the effect of GA on TF-1 @entity1778 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity584 and @entity3470 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity4104 phosphorylation in vitro. We also evaluated the anti- @entity5 effect of GA in TF-1 @entity5 bearing BALB/c @entity19 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity5 growth in vivo and down-regulated @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 @entity5 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity1778 that targets the @entity584 / @entity3470 / @entity4104 pathway.

title: XXXX inhibits @entity1778 cell growth and migration via blocking @entity584 / @entity3470 / @entity4104 signaling.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity11950 :: ('MESH:D019695', 'Chemical') :: ['Glycyrrhizic acid']

answer: @entity11950 :: (MESH:D019695,Chemical) :: ['Glycyrrhizic acid']


abstract: @entity11950 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity5 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity1778 cells growth, migration, and the mechanisms underlying the anti- @entity5 activities of GA. @entity98 test was used to detect the effect of GA on TF-1 @entity1778 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity584 and @entity3470 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity4104 phosphorylation in vitro. We also evaluated the anti- @entity5 effect of GA in TF-1 @entity5 bearing BALB/c @entity19 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity5 growth in vivo and down-regulated @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 @entity5 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity1778 that targets the @entity584 / @entity3470 / @entity4104 pathway.

title: @entity11950 inhibits @entity1778 cell growth and migration via blocking @entity584 / @entity3470 / XXXX signaling.

answer: @entity4104 :: (6774,Gene) :: ['STAT3']


abstract: @entity11950 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity5 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity1778 cells growth, migration, and the mechanisms underlying the anti- @entity5 activities of GA. @entity98 test was used to detect the effect of GA on TF-1 @entity1778 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity584 and @entity3470 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity4104 phosphorylation in vitro. We also evaluated the anti- @entity5 effect of GA in TF-1 @entity5 bearing BALB/c @entity19 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity5 growth in vivo and down-regulated @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 @entity5 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity1778 that targets the @entity584 / @entity3470 / @entity4104 pathway.

title: @entity11950 inhibits @entity1778 cell growth and migration via blocking @entity584 / XXXX / @entity4104 signaling.

answer: @entity3470 :: (21977(Tax:10090),Gene) :: ['mTOR']


abstract: @entity11950 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity5 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity1778 cells growth, migration, and the mechanisms underlying the anti- @entity5 activities of GA. @entity98 test was used to detect the effect of GA on TF-1 @entity1778 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity584 and @entity3470 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity4104 phosphorylation in vitro. We also evaluated the anti- @entity5 effect of GA in TF-1 @entity5 bearing BALB/c @entity19 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity5 growth in vivo and down-regulated @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 @entity5 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity1778 that targets the @entity584 / @entity3470 / @entity4104 pathway.

title: @entity11950 inhibits XXXX cell growth and migration via blocking @entity584 / @entity3470 / @entity4104 signaling.

answer: @entity1778 :: (MESH:D007938,Disease) :: ['leukemia']


abstract: @entity11950 (GA) is the bioactive compound of licorice and has been used as an herbal medicine because of its anti-viral, anti- @entity5 , and anti-inflammatory properties. This study was designed to investigate the effects of GA on @entity1778 cells growth, migration, and the mechanisms underlying the anti- @entity5 activities of GA. @entity98 test was used to detect the effect of GA on TF-1 @entity1778 cell growth. Wound closure assay and Transwell were adopted to assess the effect of GA on TF-1 migration and invasion. Migration and invasion related proteins including @entity584 and @entity3470 were detected by western blot assay. We further used western blot and immunofluorescence assay to evaluate the effect of GA on @entity4104 phosphorylation in vitro. We also evaluated the anti- @entity5 effect of GA in TF-1 @entity5 bearing BALB/c @entity19 model. The present study showed GA significant inhibit of TF-1 proliferation in a dose and time-dependent manner. GA could remarkably inhibit TF-1 cell migration and invasion; meanwhile effectively suppress @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 cells. GA in 100 mg/kg/ could inhibit the @entity5 growth in vivo and down-regulated @entity584 , @entity3470 , and @entity4104 phosphorylation in TF-1 @entity5 tissues. Our findings suggest that GA is a promising therapeutic agent for @entity1778 that targets the @entity584 / @entity3470 / @entity4104 pathway.

title: @entity11950 inhibits @entity1778 cell growth and migration via blocking XXXX / @entity3470 / @entity4104 signaling.

answer: @entity584 :: (207,Gene) :: ['AKT']


abstract: Endometriosis involving intestinal mucosa is relatively uncommon. It poses a diagnostic challenge for clinicians and pathologists. We herein report a case of colonoscopic specimen revealing @entity33 . A 39-year-old @entity1 complained of red @entity548 and intermittent @entity490 . Colonoscopic examination showed a rectal mass with @entity1066 and circum wall involvement. Biopsy was processed in the suspicious of @entity189 . Morphologically, irregular glands replaced residual colorectal ones, displayed mucin depletion, nuclear stratification and subtile subnuclear vacuoles. The stroma was full of spindle cells with abundant pink cytoplasm and unclear boundary. Due to subjectively interpreting as @entity6349 in desmoplastic setting, primary @entity420 was firstly raised. Immunohistochemically, @entity5822 , ER and @entity2282 identified the essence of ectopic endometrium. @entity2225 and @entity6628 highlighted residual glands. In case of misdiagnosis, any pathologists should be aware of intestinal @entity46 for each female's colorectal biopsy, especially for that morphology not typical for primary @entity420 or @entity46 . Reading slides carefully combined with a panel of immunomarkers would solve the pitfall.

title: XXXX primarily misinterpreted as @entity420 : a case report and review of literature.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['rectal bleeding']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['rectal mucosal endometriosis']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['rectal adenocarcinoma', 'adenocarcinoma']

entities_list: @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic glands']

answer: @entity33 :: (MESH:D052016,Disease) :: ['Rectal mucosal endometriosis']


abstract: Endometriosis involving intestinal mucosa is relatively uncommon. It poses a diagnostic challenge for clinicians and pathologists. We herein report a case of colonoscopic specimen revealing @entity33 . A 39-year-old @entity1 complained of red @entity548 and intermittent @entity490 . Colonoscopic examination showed a rectal mass with @entity1066 and circum wall involvement. Biopsy was processed in the suspicious of @entity189 . Morphologically, irregular glands replaced residual colorectal ones, displayed mucin depletion, nuclear stratification and subtile subnuclear vacuoles. The stroma was full of spindle cells with abundant pink cytoplasm and unclear boundary. Due to subjectively interpreting as @entity6349 in desmoplastic setting, primary @entity420 was firstly raised. Immunohistochemically, @entity5822 , ER and @entity2282 identified the essence of ectopic endometrium. @entity2225 and @entity6628 highlighted residual glands. In case of misdiagnosis, any pathologists should be aware of intestinal @entity46 for each female's colorectal biopsy, especially for that morphology not typical for primary @entity420 or @entity46 . Reading slides carefully combined with a panel of immunomarkers would solve the pitfall.

title: @entity33 primarily misinterpreted as XXXX : a case report and review of literature.

answer: @entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma']


abstract: Management of three @entity1 with necrotizing @entity281 resulting in tracheal dissolution was reviewed with respect to presentation, cause, and management. Loss of tracheal substance led to difficulty in ventilation because of a large air leak. The stomal area cavitated in two @entity1 , denuding the right common carotid artery in one. Purulent peristomal drainage was present in all three @entity1 . Common factors of possible etiologic significance included necrotizing polymicrobial gram-negative @entity281 caused by Pseudomonas, Enterobacter, and @entity4005 species. Also of possible importance were suture fixation of the appliance, history of @entity16 , and closure of the incision. Immediate therapy consisted of oral intubation for ventilatory purposes and a regimen of hourly application of 1% @entity5154 dressings. Seven to 21 days were necessary to allow formation of sufficient granulation tissue to support replacement of the tracheostomy appliance for continued mechanical ventilation. Once spontaneous ventilation was possible, a Montgomery T-tube was inserted for long-term tracheal stenting prior to reconstruction. The two @entity1 treated by tracheal stenting are long-term survivors. Avoidance of suture fixation of the appliance, aggressive treatment of @entity281 , and adequate stomal toilet may help to avoid this devastating complication.

title: Management of necrotizing XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic injury']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['bronchopulmonary infection', 'tracheobronchial infections', 'tracheostomy infections']

entities_list: @entity5154 :: ('MESH:D009355', 'Chemical') :: ['neomycin']

entities_list: @entity4005 :: ('MESH:D007710', 'Disease') :: ['Klebsiella']

answer: @entity281 :: (MESH:D007239,Disease) :: ['tracheostomy infections']


abstract: UNASSIGNED: Background. Chemotherapy and targeted drugs are important tools in the treatment of @entity5 . A number of the planned treatments are cancelled late which is a great challenge for the clinic to minimize in order to prevent the risk for misused resources. The aim of this study was to analyze the frequency and reasons for late (<48 hours) cancellations and also to get an overview of all intravenous medical anti- @entity5 treatment at the clinic. Material and methods. During four weeks in October 2010 all @entity1 with intravenously administered chemotherapy and/or targeted drugs were registered at the Department of Oncology, Karolinska University Hospital. The survey comprehends the vast majority of all such treatment for solid @entity5 in adult @entity1 in the Stockholm region with two million inhabitants. All @entity40396 including their reasons were recorded. Diagnoses, treatment indication, line of treatment and survival, in particular short term survival, were analyzed. Results. Almost 3000 bookings for 1460 @entity1 were included and 13% were cancelled late. @entity1 detoriation was the dominating cause for late cancellation in @entity1 with palliative treatment (59%), while hematological @entity137 was most common in the adjuvant group (42%). The most common treatment indication was palliative (62%). Of the palliative treatments, 95% where given in the first to third treatment line. @entity0 (31.9%) and @entity14 (29.9%) were the two most common diagnoses. Seventy-one @entity1 (4.9%) died within two months after the treatment. Conclusion. A more careful selection and monitoring of the @entity1 might reduce the number of late cancellations due to @entity1 detoriation. To record performance status (PS) as a routine for all @entity1 might be helpful in that process. If the number of late cancellations could be reduced, resources at the clinic could be used more efficiently.

title: Why is intravenous chemotherapy cancelled and how often. Could it be prevented? A prospective analysis of all planned and given intravenous anti- XXXX treatments at the Department of Oncology, Karolinska University Hospital, Stockholm during one month.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'malignant diseases', 'tumors']

entities_list: @entity40396 :: ('MESH:C562993', 'Disease') :: ['bookings and late cancellations']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: OBJECTIVES: Situational analysis of @entity3754 ( @entity3754 ) morbidity and its management in Ahanta West, Ghana, to identify potential barrier to health care for @entity3754 @entity1 . METHODS: Lymphoedema and hydrocoele @entity1 were identified by community health workers from a subset of villages, and were interviewed and participated in focus group discussions to determine their attitudes and practices towards managing their morbidity, and their perceived barriers to accessing care. Local health professionals were also interviewed to obtain their views on the availability of morbidity management services in the district. RESULTS: 62 @entity1 (34 lymphoedema and 28 hydrocoeles) and 13 local health professionals were included in the study. Lymphoedema @entity1 predominantly self-managed their conditions, which included washing with soap and water (61.8%), and exercising the affected area (52.9%). Almost 65% of @entity1 had sought medical assistance at some stage, but support was generally limited to receiving tablets (91%). Local health professionals reported rarely seeing lymphoedema @entity1 , citing stigma and lack of provisions to assist @entity1 as a reason for this. Almost half of hydrocoele @entity1 (44%) chose not to seek medical assistance despite the negative impact it had on their lives. Whilst surgery itself is free with national health insurance, 63% those who had not sought treatment stated that indirect costs of surgery (travel costs, loss of earnings etc) were the most prohibitive factor to seeking treatment. CONCLUSIONS: The information obtained from this study should now be used to guide future morbidity strategies in building a stronger relationship between the local health services and @entity3754 @entity1 , in order to ultimately improve @entity1 ' physical, psychological and economic wellbeing. This article is protected by copyright. All rights reserved.

title: Situational Analysis of XXXX Morbidity in Ahanta West District of Ghana.

entities_list: @entity3754 :: ('MESH:D004605', 'Disease') :: ['lymphatic filariasis', 'LF']

answer: @entity3754 :: (MESH:D004605,Disease) :: ['Lymphatic Filariasis']


abstract: @entity1636 ( @entity1636 ) is a rare @entity5 with an incidence of 0.7-2.0 cases/million habitants/year. The diagnosis of @entity5 relies on careful investigations of clinical, biological, and imaging features before surgery and pathological examination after @entity5 removal. Most @entity1 present with @entity479 hormone excess or abdominal mass effects, but 15% of @entity1 with @entity1636 is initially diagnosed incidentally. After the diagnosis, in order to assess the @entity1636 prognosis and establish an adequate basis for treatment decisions different tools are proposed. The stage classification proposed by the European Network for the Study of @entity5 (ENSAT) is recommended. Pathology reports define the Weiss score, the resection status and the proliferative index, including the mitotic count and the Ki67 index. As far as the treatment is concerned, in case of @entity5 limited to the adrenal gland, the complete resection of the @entity5 is the first option. Most @entity1 benefit from adjuvant @entity8449 treatment. In metastatic disease, @entity8449 is the cornerstone of initial treatment, and cytotoxic drugs should be added in case of progression. Recently, the First International Randomized (FIRM-ACT) Trial in metastatic @entity1636 reported the association between @entity8449 and @entity2879 / @entity632 / @entity900 (EDP) as the new standard in first line treatment of @entity1636 . In last years, new targeted therapies, including the IGF-1 receptor inhibitors, have been investigated, but their efficacy remains limited. Thus, new treatment concepts are urgently needed. The ongoing "omic approaches" and next-generation sequencing will improve our understanding of the pathogenesis and hopefully will lead to better therapies.

title: XXXX ( @entity1636 ): diagnosis, prognosis, and treatment.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity8449 :: ('MESH:D008939', 'Chemical') :: ['mitotane']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Adrenal Tumors', 'malignancy']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2879 :: ('MESH:D005047', 'Chemical') :: ['etoposide']

entities_list: @entity1636 :: ('MESH:D018268', 'Disease') :: ['ACC', 'Adrenocortical carticnoma']

answer: @entity1636 :: (MESH:D018268,Disease) :: ['Adrenocortical carcinoma']


abstract: @entity1636 ( @entity1636 ) is a rare @entity5 with an incidence of 0.7-2.0 cases/million habitants/year. The diagnosis of @entity5 relies on careful investigations of clinical, biological, and imaging features before surgery and pathological examination after @entity5 removal. Most @entity1 present with @entity479 hormone excess or abdominal mass effects, but 15% of @entity1 with @entity1636 is initially diagnosed incidentally. After the diagnosis, in order to assess the @entity1636 prognosis and establish an adequate basis for treatment decisions different tools are proposed. The stage classification proposed by the European Network for the Study of @entity5 (ENSAT) is recommended. Pathology reports define the Weiss score, the resection status and the proliferative index, including the mitotic count and the Ki67 index. As far as the treatment is concerned, in case of @entity5 limited to the adrenal gland, the complete resection of the @entity5 is the first option. Most @entity1 benefit from adjuvant @entity8449 treatment. In metastatic disease, @entity8449 is the cornerstone of initial treatment, and cytotoxic drugs should be added in case of progression. Recently, the First International Randomized (FIRM-ACT) Trial in metastatic @entity1636 reported the association between @entity8449 and @entity2879 / @entity632 / @entity900 (EDP) as the new standard in first line treatment of @entity1636 . In last years, new targeted therapies, including the IGF-1 receptor inhibitors, have been investigated, but their efficacy remains limited. Thus, new treatment concepts are urgently needed. The ongoing "omic approaches" and next-generation sequencing will improve our understanding of the pathogenesis and hopefully will lead to better therapies.

title: @entity1636 ( XXXX ): diagnosis, prognosis, and treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity1636 :: (MESH:D018268,Disease) :: ['ACC']


abstract: BACKGROUND: Previous findings on the association between stress during pregnancy and @entity393 are inconsistent. We aimed to estimate this association using a large prospective cohort. METHODS: This population-based study included all 1   303   660 clinically recognised pregnancies in Denmark between 1995 and 2008. We categorised @entity1 as exposed to severe stress if they lost a @entity1 , sibling or parent during pregnancy. Cox Proportional Hazards models were used to study the association between exposure and rate of @entity5617 , starting with the follow-up on the day of completion of week 4 of pregnancy. In an attempt to control for unknown potential confounders, we also designed a pregnancy-matched analysis in which each @entity1 had her own baseline risk of @entity393 and controls therefore for genetic and time-stable environmental factors. RESULTS: A total of 146   031 pregnancies ended in clinically recognised fetal loss (11.2%) and a total of 10   808 (0.8%) @entity1 were categorised as exposed. The overall risk of @entity393 was similar in the exposed and unexposed (aHR=1.05, 95% CI 0.95 to 1.15). Results from the pregnancy-matched analysis (performed in 423 @entity1 ) showed stronger and significant associations (aHR=1.83, 95% CI 1.49 to 2.25). All the analyses indicated a stronger effect of bereavement when the mother lost a @entity1 or when the @entity204 was unexpected. CONCLUSIONS: Our main results suggested no strong association between severe stress during pregnancy and risk of @entity393 . Results from the pregnancy-matched analyses considered information from a selected and small group of @entity1 for whom there may exist a stronger association between stress during pregnancy and @entity393 . The fact that an unexpected @entity204 or the loss of a @entity1 had a stronger effect in both analyses may indicate that severe stressful situations increase the risk of @entity393 .

title: Severe stress following bereavement during pregnancy and risk of XXXX : results from a population-based cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'child']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['pregnancy loss']

entities_list: @entity5617 :: ('MESH:D005313', 'Disease') :: ['fetal death']

answer: @entity393 :: (MESH:D034381,Disease) :: ['pregnancy loss']


abstract: OBJECTIVE: The aim of this study was to determine the effect of plant-based diets on @entity353 . METHODS: @entity1 were enrolled in a 6-mo, five-arm, randomized controlled trial in 2013 in South Carolina. @entity1 attended weekly group meetings, with the exception of the omnivorous group, which served as the control and attended monthly meetings augmented with weekly e-mail lessons. All groups attended monthly meetings for the last 4 mo of the study. Diets did not emphasize caloric restriction. RESULTS: Overweight adults (body mass index 25-49.9 kg/m(2); age 18-65 y, 19% non-white, and 27% @entity1 ) were randomized to a low-fat, low-glycemic index diet: vegan (n = 12), vegetarian (n = 13), pesco-vegetarian (n = 13), semi-vegetarian (n = 13), or omnivorous (n = 12). Fifty (79%) @entity1 completed the study. In intention-to-treat analysis, the linear trend for @entity353 across the five groups was significant at both 2 (P < 0.01) and 6 mo (P < 0.01). At 6 mo, the @entity353 in the vegan group (-7.5%    4.5%) was significantly different from the omnivorous (-3.1%    3.6%; P = 0.03), semi-vegetarian (-3.2%    3.8%; P = 0.03), and pesco-vegetarian (-3.2%    3.4%; P = 0.03) groups. Vegan @entity1 decreased their fat and saturated fat more than the pesco-vegetarian, semi-vegetarian, and omnivorous groups at both 2 and 6 mo (P < 0.05). CONCLUSIONS: Vegan diets may result in greater @entity353 than more modest recommendations.

title: Comparative effectiveness of plant-based diets for XXXX : A randomized controlled trial of five different diets.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'men']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

answer: @entity353 :: (MESH:D015431,Disease) :: ['weight loss']


abstract: UNASSIGNED: @entity6662 diuretics (TDs) are a cost-effective first-line therapy for uncomplicated @entity101 ; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic @entity101 @entity1 on monotherapy for @entity101 were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 @entity101 @entity1 , 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated @entity101 .

title: Comparison of the Effect of XXXX Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive', 'hypertension']

answer: @entity6662 :: (D049971,Chemical) :: ['Thiazide']


abstract: UNASSIGNED: @entity6662 diuretics (TDs) are a cost-effective first-line therapy for uncomplicated @entity101 ; however, they are less prescribed than other options. The authors aimed to assess the noninferiority of TDs relative to different classes of antihypertensive medications in relation to central blood pressure. Cross-sectional data from the Quebec CARTaGENE project was used. Nondiabetic @entity101 @entity1 on monotherapy for @entity101 were studied. Separate adjusted models were constructed to establish noninferiority of TDs to non-TD antihypertensive medications for central blood pressure measurements. Models included a set of potential confounders. Of the 1194 @entity101 @entity1 , 7.4% were taking TDs. We found that TDs were comparable with non-TD antihypertensive medications for central systolic blood pressure (adjusted regression coefficient, 0.45; 95% confidence interval, -1.61 to 2.50). No differences in other central measurements were noted. The results provide additional support that TDs are at least as effective as other first-line medications for treating uncomplicated @entity101 .

title: Comparison of the Effect of @entity6662 Diuretics and Other Antihypertensive Drugs on Central Blood Pressure: Cross-Sectional Analysis Among Nondiabetic XXXX .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: Aging is related to declined cardiac hemodynamic function. As pumping performance may be significantly related to slowed ventricular depolarization and non-synchronous contraction, we hypothesized that aging may cause dysfunction of intercalated disc (ID), which is the structure responsible for intercellular electrical communication between cardiomyocytes. METHODS: Male C57BL/6J @entity19 were used for the study at two ages: 4 and 24 months. Electrocardiographic recording was made to analyze the time of ventricular depolarization. Then @entity19 were killed, and the hearts were harvested for examination in transmission electron microscopy (TEM) and immunofluorescence imaging. The expression of @entity16899 ( @entity16899 ), @entity21043 , and b-catenin in the myocardium of the left ventricle was evaluated using Western blotting. RESULTS: In senescent @entity19 , analysis of averaged QRS complex showed its significant prolongation. At the ultrastructural level, we found frequent disruptions of the ID (affecting 29  5% of them), mainly at the site of adherens junction, with relatively preserved desmosomal intercellular connections and diminished number of gap junctions. Western blotting revealed significantly decreased abundance of @entity16899 protein in aged animals, which may cause slowed impulse propagation through the gap junctions and contribute to the observed electrocardiographic alterations. The level of RNA for @entity16899 is similar between young and old animals, which suggests a post-transcriptional mechanism of @entity16899 protein downregulation. CONCLUSIONS: Our study shows age-related disorganization of ID, which may be responsible for slowed conduction of the depolarization wave within the heart, and supports the hypothesis of @entity299 in senescence.

title: Remodeling of the intercalated disc related to aging in the XXXX heart.

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: This is an analysis of 71 @entity1 with clinically resectable @entity188 treated with preoperative irradiation and surgery at the University of Florida from July 1975 through December 1981. Seven @entity1 were found to have liver @entity3 at surgery; six had a complete resection of their primary @entity75 and one had an incomplete resection of the @entity5 . The remaining 64 @entity1 had no evidence of @entity3 at the time of surgery and underwent a complete resection of their @entity5 . In the early years of the trial, the maximum @entity5 dose consisted of 3000 to 3500 rad in 3.5 to 4 weeks; the dose was subsequently increased to 4500 rad in 5 weeks. @entity1 were taken to surgery between 2 and 11 weeks (mean, 3.5 weeks) following the completion of radiation therapy. All @entity1 have a minimum follow-up of 3 years and 63% have a minimum follow-up of 5 years. The acute complications of treatment have been acceptable, with only one @entity1 requiring a treatment rest for moist desquamation of the perineum. All @entity1 completed the irradiation course and all were operated on. Pathologic examination of the surgical specimen revealed no @entity5 in 11%, and the incidence of positive lymph nodes was 19%, which was half the incidence of positive lymph nodes in a series of historical controls treated from 1959 to 1976 with surgery alone. Comparison of @entity1 treated with preoperative irradiation and surgery with those treated with surgery alone revealed that the @entity260 have been similar in incidence, distribution, and severity. There have been no postoperative deaths. The overall incidence of local-regional recurrence is 5/64 (7.8%), and the combined incidence of local-regional recurrence and/or distant @entity3 is 18/64 (28%). The incidence of local-regional recurrence by preoperative dose is 3/23 (13%) for doses of 3000 to 3500 rad and 2/41 (5%) for doses of 4000 to 5000 rad. The 5-year local-regional failure rate is 3/40 (7.5%) for the group irradiated before surgery, and 39/135 (29%) for the historical controls managed by surgery alone (significance level = 0.015). The 5-year determinate disease-free survival is 27/38 (71%) for the @entity1 irradiated before surgery, and 47/114 (41%) for the historical group of @entity1 treated with surgery alone (significance level = 0.008).

title: Preoperative radiation therapy for clinically resectable XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['rectal lesion']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal tumor', 'rectal cancer']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity188 :: ('MESH:D012004', 'Disease') :: ['adenocarcinoma of the rectum']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity188 :: (MESH:D012004,Disease) :: ['adenocarcinoma of the rectum']


abstract: During the past five years, 65 @entity1 were treated for @entity6177 unassociated with prior operation. Radiologic tests proved quite accurate in confirming the diagnosis. Abdominal x-ray films were abnormal in 25 (57%) of 44 @entity1 , as were ultrasonograms in 33 (89%) of 37 @entity1 , computed tomography scans in 13 (100%) of 13 @entity1 , and @entity2719 scans in five (100%) of five @entity1 . Celiotomy was performed in each @entity1 with both abscess drainage and the appropriate management of the diseased organ. Seven @entity1 (10.8%) died, and in five @entity204 was due to uncontrolled @entity295 . Duration of hospitalization averaged 23 days (seven days preoperatively and 16 days postoperatively). Twenty-two (34%) of 65 @entity1 had an incorrect preoperative diagnosis leading to prolonged antibiotic treatment and delay in operation. The mortality was significant in seven (10.8%) of 65 @entity1 , unrelated to the type of operative drainage (Penrose v sump) but clearly related to uncontrolled @entity1320 . A heightened suspicion of this problem should allow for an earlier diagnosis and an improved outcome. Prompt abdominal reexploration is indicated in those @entity1 manifesting continued evidence of @entity295 or organ failure.

title: XXXX unassociated with prior operation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6177 :: ('MESH:D018784', 'Disease') :: ['intra-abdominal abscesses']

entities_list: @entity1320 :: ('MESH:D059413', 'Disease') :: ['intra-abdominal sepsis']

answer: @entity6177 :: (MESH:D018784,Disease) :: ['Intra-abdominal abscess']


abstract: PURPOSE: @entity11627 ( @entity11627 ), or Ondine's curse, is a @entity395 affecting central respiratory drive. @entity1 with this disorder fail to ventilate adequately and require lifelong ventilatory support. Diaphragm pacing is a form of ventilatory support which can improve mobility and/or remove the tracheostomy from @entity11627 @entity1 . Little is known about complications and long-term outcomes of this procedure. METHODS: A single-center retrospective review was performed of @entity11627 @entity1 undergoing placement of phrenic nerve electrodes for diaphragm pacing between 2000 and 2012. Data abstracted from the medical record included operation duration, ventilation method, number of trocars required, and postoperative and pacing outcomes. RESULTS: Charts of eighteen @entity1 were reviewed. Mean surgical time was 3.3  0.7hours. In all cases except one, three trocars were utilized for each hemithorax, with no conversions to open procedures. Five @entity1 (27.8%) experienced @entity260 . The mean ICU stay was 4.3  0.5days, and the mean hospital stay is 5.7  0.3days. Eleven @entity1 (61.1%) achieved their daily goal pacing times within the follow-up period. CONCLUSIONS: Thoracoscopic placement of phrenic nerve electrodes for diaphragmatic pacing is a safe and effective treatment modality for @entity11627 . Observed complications were temporary, and the majority of @entity1 were able to achieve pacing goals.

title: Thoracoscopic placement of phrenic nerve pacers for diaphragm pacing in XXXX .

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity11627 :: ('MESH:C536209', 'Disease') :: ['CCHS', 'Congenital central hypoventilation syndrome']

answer: @entity11627 :: (MESH:C536209,Disease) :: ['congenital central hypoventilation syndrome']


abstract: INTRODUCTION: Gradual reduction of the dosage of @entity1063 (NE) in @entity1 with @entity326 is usually left to the physician's discretion. No hemodynamic indicator predictive of the possibility of decreasing the NE dosage is currently available at the bedside. The respiratory pulse pressure variation/respiratory @entity64 volume variation (dynamic arterial elastance (Eadyn)) ratio has been proposed as an indicator of vascular tone. The purpose of this study was to determine whether Eadyn can be used to predict the decrease in arterial pressure when decreasing the NE dosage in resuscitated @entity295 @entity1 . METHODS: A prospective study was carried out in a university hospital intensive care unit. All consecutive @entity1 with @entity326 monitored by PICCO2 for whom the intensive care physician planned to decrease the NE dosage were enrolled. Measurements of hemodynamic and PICCO2 variables were obtained before/after decreasing the NE dosage. Responders were defined by a >15% decrease in mean arterial pressure (MAP). RESULTS: In total, 35 @entity1 were included. MAP decreased by >15% after decreasing the NE dosage in 37% of @entity1 (n   =   13). Clinical characteristics appeared to be similar between responders and nonresponders. Eadyn was lower in responders than in nonresponders (0.75 (0.69 to 0.85) versus 1 (0. 83 to 1.22), P   <0.05). Baseline Eadyn was correlated with NE-induced MAP variations (r   =   0.47, P   =   0.005). An Eadyn less than 0.94 predicted a decrease in arterial pressure, with an area under the receiver-operating characteristic curve of 0.87 (95% confidence interval (95% CI): 0.72 to 0.96; P   <0.0001), 100% sensitivity, and 68% specificity. CONCLUSIONS: In @entity295 @entity1 treated with NE, Eadyn may predict the decrease in arterial pressure in response to NE dose reduction. Eadyn may constitute an easy-to-use functional approach to arterial-tone assessment, which may be helpful to identify @entity1 likely to benefit from NE dose reduction.

title: Dynamic arterial elastance predicts mean arterial pressure decrease associated with decreasing XXXX dosage in @entity326 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity326 :: ('MESH:D012772', 'Disease') :: ['septic shock']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

answer: @entity1063 :: (MESH:D009638,Chemical) :: ['norepinephrine']


abstract: INTRODUCTION: Gradual reduction of the dosage of @entity1063 (NE) in @entity1 with @entity326 is usually left to the physician's discretion. No hemodynamic indicator predictive of the possibility of decreasing the NE dosage is currently available at the bedside. The respiratory pulse pressure variation/respiratory @entity64 volume variation (dynamic arterial elastance (Eadyn)) ratio has been proposed as an indicator of vascular tone. The purpose of this study was to determine whether Eadyn can be used to predict the decrease in arterial pressure when decreasing the NE dosage in resuscitated @entity295 @entity1 . METHODS: A prospective study was carried out in a university hospital intensive care unit. All consecutive @entity1 with @entity326 monitored by PICCO2 for whom the intensive care physician planned to decrease the NE dosage were enrolled. Measurements of hemodynamic and PICCO2 variables were obtained before/after decreasing the NE dosage. Responders were defined by a >15% decrease in mean arterial pressure (MAP). RESULTS: In total, 35 @entity1 were included. MAP decreased by >15% after decreasing the NE dosage in 37% of @entity1 (n   =   13). Clinical characteristics appeared to be similar between responders and nonresponders. Eadyn was lower in responders than in nonresponders (0.75 (0.69 to 0.85) versus 1 (0. 83 to 1.22), P   <0.05). Baseline Eadyn was correlated with NE-induced MAP variations (r   =   0.47, P   =   0.005). An Eadyn less than 0.94 predicted a decrease in arterial pressure, with an area under the receiver-operating characteristic curve of 0.87 (95% confidence interval (95% CI): 0.72 to 0.96; P   <0.0001), 100% sensitivity, and 68% specificity. CONCLUSIONS: In @entity295 @entity1 treated with NE, Eadyn may predict the decrease in arterial pressure in response to NE dose reduction. Eadyn may constitute an easy-to-use functional approach to arterial-tone assessment, which may be helpful to identify @entity1 likely to benefit from NE dose reduction.

title: Dynamic arterial elastance predicts mean arterial pressure decrease associated with decreasing @entity1063 dosage in XXXX .

answer: @entity326 :: (MESH:D012772,Disease) :: ['septic shock']


abstract: BACKGROUND: SRQ-20 is a validated screening tool for common @entity146 in several countries. Exploration of the latent structure of this instrument resulted in conflicting evidence. This study aimed to explore the latent structure of SRQ-20 among Brazilian @entity1 from community settings. We also tested the model invariance across different sociodemographic conditions. METHODS: Exploratory factor analysis (EFA) and confirmatory factor analysis ( @entity3795 ) were conducted on a sample of 1668 @entity1 from four different geographical regions of Brazil. Invariance of the model was tested through multi-group @entity3795 according to sociodemographic variables. RESULTS: EFA has shown two potential solutions with two and three factors. @entity3795 resulted in indices of the two-factor solution slightly worse than the three-factor solution. Invariance testing has shown this model was not invariant across cities, but was invariant across different social classes. The structure was also invariant for the two lower educated groups. The respecified model (i.e., excluding item 16) was not invariant across groups with different educational levels. CONCLUSION: The three-factor solution seems to be the most suitable model of SRQ-20 for Brazilian @entity1 in community settings. Furthermore, sociodemographic variables seem to reflect on the latent structure of this instrument. Validation of screening tools should consider sociodemographic variables.

title: Psychometric properties of the self-reporting questionnaire (SRQ-20): Measurement invariance across XXXX from Brazilian community settings.

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: UNASSIGNED: The objective of this study was to determine the expression and effects of B-lymphocyte stimulator (BLyS) in T cell-mediated @entity625 , a @entity35 model of @entity1 @entity309 ( @entity309 ). @entity35 @entity1753 ( @entity1753 ) was induced by intradermal injection of 0.1ml complete Freund's adjuvant. @entity625 was evaluated by the histopathological examination of joint ankle. The BLyS expression was detected by immunohistochemical analysis. The level of BLyS and @entity7940 were assayed by enzyme-linked immunosorbent assay. The gene expression of BLyS and its receptors (TACI, BCMA and BAFF-R) were assessed by quantitative reverse-transcription polymerase chain reaction. The effect of BLyS on the function of T cell was investigated by transwell assay. Using an @entity1753 @entity35 model, we detected dysregulated expression and level of BLyS and its receptors in the local joint synovium tissue, peripheral lymphoid organs (spleen) and immune cells (macrophage, dendritic cells (DC) and T cell) at the peak of @entity32 . In vitro, BLyS-treated DC induced @entity7940 producing T cells. Neutralization of BLyS by the TACI-Ig fusion protein attenuated these stimulating effects of BLyS. These data suggest that the overproduction of BLyS may contribute to T cell responses and may be an attractive target for control of @entity792 , such as @entity309 , that involves both T and B cells.

title: Expression and effects of B-lymphocyte stimulator and its receptors in T cell-mediated XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['autoimmune arthritis', 'Arthritis']

entities_list: @entity1753 :: ('MESH:D001169', 'Disease') :: ['adjuvant-induced arthritis', 'AA']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity625 :: (MESH:D001168,Disease) :: ['autoimmune arthritis']


abstract: AIMS: To examine treatment options selected for recurrent stress @entity322 (rSUI) in follow-up after Burch, autologous fascial and synthetic midurethral sling (MUS) procedures. METHODS: We performed a secondary analysis of the SISTER and ToMUS trials of @entity1 who underwent primary stress @entity322 (SUI) treatment (without prior SUI surgery or concomitant procedures). Using Kaplan-Meier analysis, retreatment-free survival rates by initial surgical procedure were compared. Mean MESA (Medical Epidemiologic and Social Aspects of Aging) stress index was also compared between those retreated for rSUI compared to those not retreated. RESULTS: Half of the @entity1 in the SISTEr trial met inclusion criteria for this analysis (329/655, 174 Burch and 155 @entity4438 ), as did 444/597 (74%) of subjects in ToMUS (221 transobturator midurethral sling (TMUS), and 223 retropubic midurethral sling (RMUS). Types of surgical retreatment included @entity4438 (19), synthetic sling (1), and bulking agent (18). Five-year retreatment free survival rates (and standard errors) were 87% (3%), 96% (2%), 97% (1%), and 99% (0.7%) for Burch, @entity4438 , TMUS, and RMUS groups respectively (P   <   0.0001). For all index surgery groups, the mean MESA stress index at last visit prior to retreatment for those retreated (n   =   23) was significantly higher than mean MESA stress index at last visit for those not retreated (n   =   645) (P   <   0.0001). CONCLUSION: In these cohorts, 6% of @entity1 after standard anti- @entity322 procedures were retreated within 5 years, mostly with injection therapy or @entity4438 . Not all @entity1 with rSUI chose surgical retreatment.

title: Management of recurrent stress XXXX after burch and sling procedures.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence', 'incontinence']

entities_list: @entity4438 :: ('MESH:C563219', 'Disease') :: ['fascial sling', 'autologous fascial sling']

answer: @entity322 :: (MESH:D014549,Disease) :: ['urinary incontinence']


abstract: BACKGROUND: It is unclear whether the rate of @entity41910 in paediatric @entity5 survivors is higher than in the background population, and whether this is of pathological significance. @entity1 AND METHODS: 25OHD was measured in a previously studied group of 208 survivors (n  =  108 paediatric 5-17  years, n  =  99 adults 18-39  years) and compared with paediatric (5-17  years; n  =  132) and adult controls (25-35  years; n  =  1393 from the AusDiab cohort) adjusted for age and gender. Relationships with treatment factors (irradiation, bone marrow transplantation and intensity of treatment) along with overweight/ @entity28 (defined by BMI), abdominal adiposity (waist:height ratio >0  5) and @entity13897 ( @entity13897 ) were sought. RESULTS: 25OHD concentrations were similar in paediatric survivors compared with controls (64  3      21  6  nmol/l vs 66  3     22  8  nmol/l), with no effect of age or gender. Adjusted for gender, rates of 25OHD deficiency (<50  nmol/l) were higher in adult survivors compared with AusDiab controls (42  4% vs 20  8%; P  <  0  001). Apart from time since diagnosis (P  =  0  03), no relationship with treatment factors was detected. In multivariate regression analysis, abdominal adiposity (P  =  0  001), but not overweight/ @entity28 by BMI status nor @entity13897 , was associated with significantly lower 25OHD concentrations. CONCLUSIONS: Adult survivors are at increased risk of @entity854 compared to the background population, probably reflecting longer time since diagnosis. Like others, we have not identified any contributory treatment-related factors. @entity41910 does not appear to be associated with the development of @entity13897 in this population.

title: The prevalence of XXXX is higher in adult survivors of childhood @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS']

entities_list: @entity13897 :: ('MESH:D018149', 'Disease') :: ['HI/aGT', 'abnormal glucose tolerance', 'hyperinsulinism or abnormal glucose tolerance']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity41910 :: ('MESH:D014808', 'Disease') :: ['Vitamin D deficiency', 'vitamin D deficiency']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormalities in vitamin D']

answer: @entity41910 :: (MESH:D014808,Disease) :: ['Vitamin D deficiency']


abstract: BACKGROUND: It is unclear whether the rate of @entity41910 in paediatric @entity5 survivors is higher than in the background population, and whether this is of pathological significance. @entity1 AND METHODS: 25OHD was measured in a previously studied group of 208 survivors (n  =  108 paediatric 5-17  years, n  =  99 adults 18-39  years) and compared with paediatric (5-17  years; n  =  132) and adult controls (25-35  years; n  =  1393 from the AusDiab cohort) adjusted for age and gender. Relationships with treatment factors (irradiation, bone marrow transplantation and intensity of treatment) along with overweight/ @entity28 (defined by BMI), abdominal adiposity (waist:height ratio >0  5) and @entity13897 ( @entity13897 ) were sought. RESULTS: 25OHD concentrations were similar in paediatric survivors compared with controls (64  3      21  6  nmol/l vs 66  3     22  8  nmol/l), with no effect of age or gender. Adjusted for gender, rates of 25OHD deficiency (<50  nmol/l) were higher in adult survivors compared with AusDiab controls (42  4% vs 20  8%; P  <  0  001). Apart from time since diagnosis (P  =  0  03), no relationship with treatment factors was detected. In multivariate regression analysis, abdominal adiposity (P  =  0  001), but not overweight/ @entity28 by BMI status nor @entity13897 , was associated with significantly lower 25OHD concentrations. CONCLUSIONS: Adult survivors are at increased risk of @entity854 compared to the background population, probably reflecting longer time since diagnosis. Like others, we have not identified any contributory treatment-related factors. @entity41910 does not appear to be associated with the development of @entity13897 in this population.

title: The prevalence of @entity41910 is higher in adult survivors of childhood XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']