abstract: @entity3932 ( @entity3932 ) ( @entity4904 ) is a @entity4848 associated with @entity3809 of the face, @entity410 , @entity1032 , and usually ipsilateral @entity693 . The classic form affects leptomeninges, eyes, and face. Although the precise etiology and pathogenesis are unclear, the @entity154 is primary @entity1211 with failure of the primordial embryonic venous plexus to regress. A spontaneous somatic mutation in fibroblast fibronectin gene expression in the @entity1462 may occur during embryonic development. Ocular involvement is characterized by conjunctival, episcleral, @entity5995 , and @entity455 . The @entity455 have been inconsistently described as @entity2695 , @entity2695 , and @entity1462 . Based on the endothelial cellular activity, they can be @entity1462 (or @entity3809 ), which never regress spontaneously. Congenital, developmental, and adult-onset @entity726 are often seen when the @entity600 involve the distribution of the first branch of the trigeminal nerve.Both mechanical and vascular causes have been proposed to account for the development of @entity726 . The mechanical theory is based on obstruction of aqueous outflow secondary to developmental anterior chamber angle abnormalities, and the vascular theory is based primarily on elevated episcleral venous pressure. Management of @entity726 in @entity1 with @entity3932 is often challenging and is aimed at controlling intraocular pressure and preventing progressive @entity227 and @entity1939 . It also carries an increased risk for surgical complications. This review summarizes the literature regarding the genetics, clinical features, and management of ocular complications of @entity3932 with special focus on @entity726 .

title: @entity4904 ( XXXX , Klippel-Trenaunay-Weber Syndrome): A Review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['postulated defect']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['choroidal vascular abnormalities', 'vascular lesions']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual loss']

entities_list: @entity2695 :: ('MESH:D006391', 'Disease') :: ['hemangiomas', 'angiomas']

entities_list: @entity3932 :: ('MESH:D013341', 'Disease') :: ['SWS', 'Sturge-Weber syndrome']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningeal vascular malformations']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['blindness']

entities_list: @entity4848 :: ('MESH:D020752', 'Disease') :: ['phakomatosis']

entities_list: @entity4904 :: ('MESH:D000798', 'Disease') :: ['encephalotrigeminal angiomatosis']

entities_list: @entity3809 :: ('MESH:D019339', 'Disease') :: ['port-wine stains']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['venous dysplasia']

entities_list: @entity1462 :: ('MESH:D054079', 'Disease') :: ['vascular malformations', 'vascular malformation', 'considered vascular malformations']

answer: @entity3932 :: (MESH:D013341,Disease) :: ['Sturge-Weber Syndrome']


abstract: @entity3932 ( @entity3932 ) ( @entity4904 ) is a @entity4848 associated with @entity3809 of the face, @entity410 , @entity1032 , and usually ipsilateral @entity693 . The classic form affects leptomeninges, eyes, and face. Although the precise etiology and pathogenesis are unclear, the @entity154 is primary @entity1211 with failure of the primordial embryonic venous plexus to regress. A spontaneous somatic mutation in fibroblast fibronectin gene expression in the @entity1462 may occur during embryonic development. Ocular involvement is characterized by conjunctival, episcleral, @entity5995 , and @entity455 . The @entity455 have been inconsistently described as @entity2695 , @entity2695 , and @entity1462 . Based on the endothelial cellular activity, they can be @entity1462 (or @entity3809 ), which never regress spontaneously. Congenital, developmental, and adult-onset @entity726 are often seen when the @entity600 involve the distribution of the first branch of the trigeminal nerve.Both mechanical and vascular causes have been proposed to account for the development of @entity726 . The mechanical theory is based on obstruction of aqueous outflow secondary to developmental anterior chamber angle abnormalities, and the vascular theory is based primarily on elevated episcleral venous pressure. Management of @entity726 in @entity1 with @entity3932 is often challenging and is aimed at controlling intraocular pressure and preventing progressive @entity227 and @entity1939 . It also carries an increased risk for surgical complications. This review summarizes the literature regarding the genetics, clinical features, and management of ocular complications of @entity3932 with special focus on @entity726 .

title: XXXX ( @entity3932 , Klippel-Trenaunay-Weber Syndrome): A Review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity4904 :: (MESH:D000798,Disease) :: ['Encephalotrigeminal Angiomatosis']


abstract: UNASSIGNED: Objective means are needed to predict and assess clinical response in @entity1 treated for @entity3 ( @entity3 ). We examined whether early changes in serum galactomannan (GM) and/or b-D-glucan (BDG) can predict clinical outcomes. @entity1 with proven or probable @entity3 were prospectively enrolled, and serial GM and BDG levels and GM optical density indices (GMI) were calculated twice weekly for 6 weeks following initiation of standard-of-care antifungal therapy. Changes in these biomarkers during the first 2 and 6 weeks of treatment were analyzed for associations with clinical response and survival at weeks 6 and 12. Among 47 @entity1 with @entity3 , 53.2% (25/47) and 65.9% (27/41) had clinical response by weeks 6 and 12, respectively. Changes in biomarkers during the first 2 weeks were associated with clinical response at 6 weeks (GMI, P = 0.03) and 12 weeks (GM+BDG composite, P = 0.05; GM, P = 0.04; GMI, P = 0.02). Changes in biomarkers during the first 6 weeks were also associated with clinical response at 6 weeks (GM, P = 0.05; GMI, P = 0.03) and 12 weeks (BDG+GM, P = 0.02; GM, P = 0.02; GMI, P = 0.01). Overall survival rates at 6 weeks and 12 weeks were 87.2% (41/47) and 79.1% (34/43), respectively. Decreasing biomarkers in the first 2 weeks were associated with survival at 6 weeks (BDG+GM, P = 0.03; BDG, P = 0.01; GM, P = 0.03) and at 12 weeks (BDG+GM, P = 0.01; BDG, P = 0.03; GM, P = 0.01; GMI, P = 0.007). Similar correlations occurred for biomarkers measured over 6 weeks. @entity1 with negative baseline GMI and/or persistently negative GMI during the first 2 weeks were more likely to have CR and survival. These results suggest that changes of biomarkers may be informative to predict and/or assess response to therapy and survival in @entity1 treated for @entity3 .

title: Correlation between Circulating Fungal Biomarkers and Clinical Outcome in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive aspergillosis', 'IA']

answer: @entity3 :: (MESH:D009362,Disease) :: ['Invasive Aspergillosis']


abstract: PURPOSE: To determine the frequency of @entity1082 ) in the placenta, in the colostrum and in the umbilical cord blood of parturient @entity1 and their newborns assisted at the Clinic of Gynecology and Obstetrics of the University Hospital of Rio Grande (RS), Brazil. METHODS: Biopsies were collected from 150 placentas on the maternal side, 150 on the fetal side, 138 samples of umbilical cord blood and 118 of the colostrum. The placenta biopsies were collected from the central and peripheral portions. DNA was extracted according to the manufacturer's protocol and to a reference found in the literature. HPV was detected by the nested polymerase chain reaction (PCR-Nested) using primers MY09/11 and @entity35555 / @entity10388 . Genotyping was performed by direct sequencing. The @entity1 responded to a self-applied questionnaire with demographic and clinical data, in order to characterize the sample. RESULTS: HPV was detected in 4% (6/150) of cases on the mother's side of the placentas, in 3.3% (5/150) on the fetal side, in 2.2% (3/138) in umbilical cord blood and in 0.84% (1/118) in colostrum samples. The vertical transmission rate was 50%. HPV-6 was the low-risk genotype found (60%) and the high-risk genotypes were @entity1799 and HPV-18 (20% each). CONCLUSIONS: These results suggest that HPV can infect the placenta, the colostrum and the umbilical cord blood.

title: [Frequency of XXXX in the placenta, in the colostrum and in the umbilical cord blood].

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity1082 :: ('10566', 'Species') :: ['Human Papillomavirus (HPV']

answer: @entity1082 :: (10566,Species) :: ['Human Papillomavirus']


abstract: PURPOSE: The purpose of this study was to characterize central @entity2994 (CRVO) with inflammatory etiology. DESIGN: A retrospective study. METHODS: We retrospectively reviewed 51 eyes of 48 @entity1 with CRVO between 2004 and 2009 and investigated whether they had inflammatory findings related to @entity4816 , that is, severe peripheral retinal vascular changes based on @entity941 angiography and anterior vitreous cells. The extent of vascular leakage was classified as "mild," "moderate," and "severe" in angiographic images. RESULTS: Six eyes of 5 @entity1 (11.8%) had both inflammatory criteria. All @entity1 were male and with a diagnosis of @entity63 CRVO. No causative etiology was detected in any @entity1 . The mean age was 46.4 (SD, 23.3) years. The age range was not limited to young generation. These @entity1 received systemic @entity228 therapy with a mean follow-up period of 41.8 months. The mean logMAR visual acuity [1.29 (SD, 0.77)] and central retinal thickness [1290.5 (SD, 399.0)  m)] at the initial visit were significantly (P = 0.004 and P = 0.001) improved at the final visit [0.94 (SD, 0.69) and 266.7 (SD, 135.4)  m, respectively]. CONCLUSIONS: Central @entity2994 with idiopathic inflammatory conditions appears to have clinical characteristics of broad age range and good response to systemic corticosteroid therapy.

title: Clinical Features of Central XXXX With Inflammatory Etiology.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity2994 :: ('MESH:D012170', 'Disease') :: ['retinal vein occlusion']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

entities_list: @entity4816 :: ('MESH:D031300', 'Disease') :: ['retinal vasculitis']

answer: @entity2994 :: (MESH:D012170,Disease) :: ['Retinal Vein Occlusion']


abstract: OBJECTIVE: To assess the trabecular bone structure of jawbones and the dens (the odontoid process of the second cervical vertebra) amongst @entity3604 and nonosteoporotic @entity1 using cone-beam computed tomography (CBCT). Analysis of the dens trabecular bone structure aimed to test the validity of CBCT in such analysis. METHODS: Thirty-eight @entity1 who went under dual-energy X-ray absorptiometry (DXA) examination were scanned by CBCT. Cuboids from different areas of jawbones and the dens were extracted from each scan. Trabecular thickness (Tb.Th), trabecular separation (Tb.S), bone volume fraction (BV/TV), specific bone surface (BS/TV) and connectivity density were calculated. Student's t-test, Pearson correlation, and logistic regression analysis were used to explore differences in these measures between groups. RESULTS: Jawbone-derived measures showed insignificant differences (P  >  0.05) between @entity3604 , and weak correlations with femoral neck and lumbar vertebrae T-scores (r   <=  0.4). Dens-derived measures, however, resulted in the opposite (r  =  0.34-0.38 [P  value  =  0.02-0.036] and r  =  0.48-0.61 [P  value   <=  0.003]) and the highest accuracy of @entity170 prediction: 84.2% and 78.9% respectively. CONCLUSION: Trabecular bone structure of the mandible and maxilla is not affected in @entity170 as assessed by CBCT. Dens trabecular bone analysis revealed the opposite, so some trabecular bone measures may be assessed by CBCT, which may aid in predicting @entity170 .

title: Assessment of jawbone trabecular bone structure amongst XXXX @entity1 by cone-beam computed tomography: the OSTEOSYR project.

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic', 'osteoporotic and non-osteoporotic groups']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

answer: @entity3604 :: (MESH:D058866,Disease) :: ['osteoporotic']


abstract: OBJECTIVE: To assess the trabecular bone structure of jawbones and the dens (the odontoid process of the second cervical vertebra) amongst @entity3604 and nonosteoporotic @entity1 using cone-beam computed tomography (CBCT). Analysis of the dens trabecular bone structure aimed to test the validity of CBCT in such analysis. METHODS: Thirty-eight @entity1 who went under dual-energy X-ray absorptiometry (DXA) examination were scanned by CBCT. Cuboids from different areas of jawbones and the dens were extracted from each scan. Trabecular thickness (Tb.Th), trabecular separation (Tb.S), bone volume fraction (BV/TV), specific bone surface (BS/TV) and connectivity density were calculated. Student's t-test, Pearson correlation, and logistic regression analysis were used to explore differences in these measures between groups. RESULTS: Jawbone-derived measures showed insignificant differences (P  >  0.05) between @entity3604 , and weak correlations with femoral neck and lumbar vertebrae T-scores (r   <=  0.4). Dens-derived measures, however, resulted in the opposite (r  =  0.34-0.38 [P  value  =  0.02-0.036] and r  =  0.48-0.61 [P  value   <=  0.003]) and the highest accuracy of @entity170 prediction: 84.2% and 78.9% respectively. CONCLUSION: Trabecular bone structure of the mandible and maxilla is not affected in @entity170 as assessed by CBCT. Dens trabecular bone analysis revealed the opposite, so some trabecular bone measures may be assessed by CBCT, which may aid in predicting @entity170 .

title: Assessment of jawbone trabecular bone structure amongst @entity3604 XXXX by cone-beam computed tomography: the OSTEOSYR project.

answer: @entity1 :: (9606,Species) :: ['women']


abstract: The aim of the experiments was to evaluate the influence of @entity1 kisspeptin on LH secretion of @entity26727 ( @entity26727 ) females during ovarian recrudescence and spawning season. For the experiments, @entity1 kisspeptin @entity33913 (0.1 mg kg(-1) of body weight--b.w.), @entity1176 analogue (Des Gly(10), D-Ala(6)) GnRH-A (20   g kg(-1) b.w.) and @entity935 antagonist ( @entity1766 ) (5 mg kg(-1) b.w.) were used alone or in combinations. At 3, 6, 12, 24 hours after injection(s) blood samples were collected from all fish. LH levels were measured in plasma with the use of the ELISA method. @entity33913 did not show any significant effects on spontaneous LH secretion in both tested seasons. At 12 hours sampling time (both stages of gonad maturity) a combination of tested compounds (GnRH-A+ @entity33913 ) significantly increased LH release in comparison with the control. In the stage of gonad recrudescence @entity33913 significantly increased LH secretion evoked by @entity1766 at 24 hours. A combination of three components: @entity33913 , GnRH-A, and @entity1766 significantly decreased LH secretion in comparison to LH secretion evoked by @entity4397 and @entity1766 during stage of gonad recrudescence. These results suggest that kisspeptin is involved in seasonal control of reproduction in @entity26727 . The possible interaction of kisspeptin and the dopaminergic system is also discussed.

title: Preliminary Results Concerning the Influence of @entity1 Kisspeptin on LH Secretion in XXXX ( @entity26727 ) Females at the Stage of Ovarian Recrudescence and Spawning Season.

entities_list: @entity26727 :: ('101364', 'Species') :: ['Prussian carp', 'Carassius gibelio']

entities_list: @entity1766 :: ('MESH:D010868', 'Chemical') :: ['pimozide']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

answer: @entity26727 :: (101364,Species) :: ['Prussian Carp']


abstract: The aim of the experiments was to evaluate the influence of @entity1 kisspeptin on LH secretion of @entity26727 ( @entity26727 ) females during ovarian recrudescence and spawning season. For the experiments, @entity1 kisspeptin @entity33913 (0.1 mg kg(-1) of body weight--b.w.), @entity1176 analogue (Des Gly(10), D-Ala(6)) GnRH-A (20   g kg(-1) b.w.) and @entity935 antagonist ( @entity1766 ) (5 mg kg(-1) b.w.) were used alone or in combinations. At 3, 6, 12, 24 hours after injection(s) blood samples were collected from all fish. LH levels were measured in plasma with the use of the ELISA method. @entity33913 did not show any significant effects on spontaneous LH secretion in both tested seasons. At 12 hours sampling time (both stages of gonad maturity) a combination of tested compounds (GnRH-A+ @entity33913 ) significantly increased LH release in comparison with the control. In the stage of gonad recrudescence @entity33913 significantly increased LH secretion evoked by @entity1766 at 24 hours. A combination of three components: @entity33913 , GnRH-A, and @entity1766 significantly decreased LH secretion in comparison to LH secretion evoked by @entity4397 and @entity1766 during stage of gonad recrudescence. These results suggest that kisspeptin is involved in seasonal control of reproduction in @entity26727 . The possible interaction of kisspeptin and the dopaminergic system is also discussed.

title: Preliminary Results Concerning the Influence of @entity1 Kisspeptin on LH Secretion in @entity26727 ( XXXX ) Females at the Stage of Ovarian Recrudescence and Spawning Season.

answer: @entity26727 :: (101364,Species) :: ['Carassius gibelio']


abstract: The aim of the experiments was to evaluate the influence of @entity1 kisspeptin on LH secretion of @entity26727 ( @entity26727 ) females during ovarian recrudescence and spawning season. For the experiments, @entity1 kisspeptin @entity33913 (0.1 mg kg(-1) of body weight--b.w.), @entity1176 analogue (Des Gly(10), D-Ala(6)) GnRH-A (20   g kg(-1) b.w.) and @entity935 antagonist ( @entity1766 ) (5 mg kg(-1) b.w.) were used alone or in combinations. At 3, 6, 12, 24 hours after injection(s) blood samples were collected from all fish. LH levels were measured in plasma with the use of the ELISA method. @entity33913 did not show any significant effects on spontaneous LH secretion in both tested seasons. At 12 hours sampling time (both stages of gonad maturity) a combination of tested compounds (GnRH-A+ @entity33913 ) significantly increased LH release in comparison with the control. In the stage of gonad recrudescence @entity33913 significantly increased LH secretion evoked by @entity1766 at 24 hours. A combination of three components: @entity33913 , GnRH-A, and @entity1766 significantly decreased LH secretion in comparison to LH secretion evoked by @entity4397 and @entity1766 during stage of gonad recrudescence. These results suggest that kisspeptin is involved in seasonal control of reproduction in @entity26727 . The possible interaction of kisspeptin and the dopaminergic system is also discussed.

title: Preliminary Results Concerning the Influence of XXXX Kisspeptin on LH Secretion in @entity26727 ( @entity26727 ) Females at the Stage of Ovarian Recrudescence and Spawning Season.

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: Kekul   first suggested a hexagonal structure for @entity7935 in 1865. For over a half-century after, chemists struggled to reconcile proposed structures for @entity7935 and other aromatic compounds with their resistance to chemical transformation and tendency to maintain the type during reaction. The combined structural and reactivity features of these compounds were eventually covered by the term ' @entity56411 '. Kekul  , Bamberger and Thiele had each proposed a criterion for @entity56411 ; all were either empirically contradicted or incapable of evaluation. In the 1930s, two rival quantum mechanical methods succeeded in establishing a physical basis for @entity56411 . Using valence bond theory, Pauling attributed @entity7935 's stability to its being a resonance hybrid of several Lewis structures. Calculating resonance energies was challenging but manipulating Lewis structures was not; that procedure provided qualitative insights into aromatic structure and reactivity. Resonance theory appealed especially to organic chemists and eclipsed H  ckel's contemporaneous molecular orbital approach, which remained relatively inaccessible. In the 1950s, however, simple rules derived from H  ckel's mathematics, combined with proton NMR data, provided seemingly universal criteria for @entity56411 . In the event, post-1950 discoveries of non-organic, three-dimensional compounds such as @entity504 and the @entity16820 that exhibit aromatic properties led chemists to doubt the utility and universality of ' @entity56411 ' as a concept. A recent consensus maintains that @entity56411 is a multi-variable phenomenon that cannot be reduced to a strict definition, a property it shares with other core chemical concepts such as 'acidity' and 'reactivity'.

title: XXXX and Beyond: Pursuing the Core of Aromaticity.

entities_list: @entity56411 :: ('MESH:C537437', 'Disease') :: ['aromaticity']

entities_list: @entity504 :: ('MESH:C004998', 'Chemical') :: ['ferrocene']

entities_list: @entity16820 :: ('MESH:D037741', 'Chemical') :: ['fullerenes']

answer: @entity7935 :: (MESH:D001554,Chemical) :: ['Benzene']


abstract: AIMS: To review retrospectively 16 cases of @entity5426 ( @entity5426 ) with emphasis on their clinical and pathological characteristics, treatment and possible prognostic factors. METHODS AND RESULTS: All eligible cases were searched and acquired from archives of the pathology departments of two hospitals in Shanghai, The Fifth @entity1 's Hospital of Shanghai, Fudan University, and the Shanghai Cancer Center, Fudan University, China. The @entity1 ranged in age from 19 to 77 years, and 5 @entity1 were below 50 years of age. Microscopically, the @entity5 were mostly composed of large, round or polygonal epithelioid cells that were predominantly arranged in solid sheets or nests. The @entity5 cells had basophilic or eosinophilic cytoplasm, vesicular nuclei, and prominent nucleoli. Mitotic figures including abnormal mitoses were frequently encountered. In all 16 cases in our series, immunohistochemical studies showed positivity for @entity2279 , and partial positivity for @entity21468 , @entity2280 and factor VIII-related antigen. Of the 14 @entity1 available for follow-up, 3 @entity1 were alive with disease, 9 @entity1 died as a result of the @entity5 , 1 died of local @entity548 , and one died of unknown etiology. The median survival was 17.1 months. CONCLUSIONS: EA is highly aggressive and carries a very poor prognosis. Therefore, the clinical recognition and correct diagnosis of EA are essential.

title: XXXX : a clinicopathological study of 16 Chinese cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'People']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['EAs', 'epithelioid angiosarcomas']

answer: @entity5426 :: (MESH:D006394,Disease) :: ['Epithelioid angiosarcoma']


abstract: UNASSIGNED: Bronchogenic cysts (BCs) are @entity600 that originate from remnants of the primitive foregut. Intraspinal BCs, especially those of the conus medullaris are rare with only one case reported until now. To date, a @entity5619 with spinal cord tethering has not been previously reported. We reviewed the clinical course of a 44-year-old @entity1 , who presented with @entity1643 and leg weaknesss as well as sphincter disturbance. Magnetic resonance imaging showed an intradural oval mass located at the conus medullaris. A tethered cord was also observed, as well as a @entity7674 . The mass was totally removed after an L3-L4 laminectomy without detethering during operation. Pathologic examination confirmed the diagnosis of @entity5619 . By six months after treatment, the @entity1 had experienced nearly complete recovery. The review of literature indicated that detethering was performed in most reported cases of @entity601 with spinal cord tethering, and one of six @entity1 was diagnosed with a postoperative recurrence. The co-existence of @entity5619 and a tethered spinal cord would imply associated developmental errors in embryogenesis. It is worth noting that whether detethering is necessary after the cyst removal.

title: XXXX with spinal cord tethering: a case report and review of the literature.

entities_list: @entity5619 :: ('MESH:D001994', 'Disease') :: ['bronchogenic cyst']

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity7674 :: ('MESH:D016136', 'Disease') :: ['dermal sinus tract']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformations']

entities_list: @entity601 :: ('MESH:D009436', 'Disease') :: ['neurenteric cysts']

answer: @entity5619 :: (MESH:D001994,Disease) :: ['Bronchogenic cyst of the conus medullaris']


abstract: BACKGROUND: @entity161 is a @entity74 . Over the years, different approaches have been proposed to approach this heterogeneity by categorizing symptom patterns. The study aimed to compare positive/negative and system-specific approaches to subtyping. METHODS: We used the Positive and Negative Syndrome Scale (PANSS) and @entity2653 ( @entity2653 ), which consists of subscales for three domains (language, affect and motor behavior) that are hypothesized to be related to specific brain circuits, to assess cross-sectional psychopathological characteristics in a sample of 100 inpatients with @entity161 spectrum disorders. We then categorized @entity1 into positive/negative and system-specific subgroups to allow comparisons of the two approaches. RESULTS: The analyses revealed correlations between the PANSS positive subscore and the @entity2653 affective subscore (r=.446, p<.001) and between the PANSS negative subscore and the @entity2653 motor behavior subscore (r=.227, p=.023). As regards the positive and negative subtype, more @entity1 were classified as positive in the language-dominant subtype (30.3%) and affect-dominant subtype (30.3%), whereas more were classified as negative in the motor behavior-dominant subtype (44.4%). However, most @entity1 met the criteria for the mixed subtype. CONCLUSIONS: The results suggest that the positive/negative and system-specific approaches can be regarded as complementary. Future studies should examine both approaches in a longitudinal assessment of psychopathological symptoms and link them with qualitative-phenomenological approaches.

title: Subtyping XXXX : A comparison of positive/negative and system-specific approaches.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity2653 :: ('MESH:C538175', 'Disease') :: ['BPS', 'Bern Psychopathology Scale']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['heterogeneous disorder']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: BACKGROUND: @entity356 ( @entity356 ) is one of the less prevalent @entity356 . The purpose of this study was to explore the clinicopathological characteristics and results of the operation of @entity356 following distal gastrectomy. In particular, we examined factors related to prognosis. METHODS: Between January 1970 and December 2012, 122 @entity1 with @entity356 following distal gastrectomy underwent further surgery and were analyzed retrospectively. RESULTS: Initial @entity1819 included benign (49 @entity1 , 40.2  %) and @entity5 (73 @entity1 , 59.8  %). Reconstructions by initial surgery included Billroth I (80 @entity1 , 65.6  %) and @entity1605 (42 @entity1 , 34.4  %). @entity5 were located at anastomotic (44 @entity1 , 36.1  %) and nonanastomotic sites (78 @entity1 , 63.9  %). There were 59 @entity1 (48.4  %) classified with pathological (p) stage I, 19 as p stage II (15.6  %), 22 as p stage III (18.0  %), and 22 (18.0  %) as p stage IV. A total of 100 @entity1 (82.0  %) underwent curative resection, and 22 underwent noncurative resection. The number of cases of postoperative morbidity, 90-day mortality, and adjuvant chemotherapy were 23 (18.9  %), 3 (2.5  %), and 20 (16.4  %), respectively. Univariate and multivariate analyses were performed to identify the prognostic factors of @entity356 . Multivariate analysis revealed historical periods, pathological @entity3 , curative resection, and postoperative morbidity to be independent prognostic factors. CONCLUSIONS: The prognosis of @entity1 with @entity356 can be improved by aggressively performing curative resection without causing complications.

title: Surgical Resection of Remnant XXXX Following Distal Gastrectomy: A Retrospective Clinicopathological Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['Billroth II']

entities_list: @entity1819 :: ('MESH:D013272', 'Disease') :: ['gastric diseases']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumors', 'malignant diseases']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['venous invasion']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['RGC', 'gastric cancers', 'Remnant gastric cancer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['Gastric Cancer']


abstract: PURPOSE: To investigate the association between @entity730 ( @entity730 ) and @entity729 ( @entity729 ) assessed by coronary artery @entity460 -scoring dual-source computed tomography (DSCT). MATERIALS AND METHODS: We retrospectively analyzed 143 consecutive @entity1 who underwent coronary artery @entity460 -scoring during coronary DSCT angiography. 57 @entity1 had findings of @entity730 on @entity460 -scoring scans. @entity730 volume (ARCV) and Agatston coronary artery @entity460 score (CACS) were calculated. Chi-square test was used to assess differences of categorical variables between @entity1 with and without @entity730 . Statistical significances between both groups were assessed with the independent-Sample t test. RESULTS: Compared with @entity1 without @entity730 (n=86), @entity1 with @entity730 (n=57) showed a significantly higher presence of @entity729 (87.7% vs. 24.4%; P<0.001), and a higher mean CACS (700.6  941.2 vs. 256.4  724.3; P=0.009) in @entity1 with @entity729 . @entity1 with a calculated ARCV >40mm(3) (n=32) showed significantly higher rates of severe @entity729 (56.3% vs. 24.0%; P=0.014) compared with @entity1 with an ARCV<40mm(3) (n=25). Compared with @entity1 without @entity729 (n=42), @entity1 with @entity729 (n=101) showed a significantly higher presence of @entity730 (83.3% vs. 50.5%; P<0.001) and a higher mean ARCV (95.4  116.2mm(3) vs. 29.7  33.0 mm(3); P=0.003). Severe @entity729 (n=24) correlated with an increased mean ARCV (122.3  148.8mm(3)) compared to @entity1 with minimal to moderate @entity729 (n=33, mean ARCV: 61.9  64.8mm(3); P<0.05). CONCLUSIONS: The extent of @entity730 is directly associated with the presence and degree of @entity729 on @entity460 -scoring scans during coronary DSCT angiography.

title: Association of XXXX severity with the extent of @entity729 assessed by @entity460 -scoring dual-source computed tomography.

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['aortic root calcification', 'ARC']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['coronary artery calcification', 'CAC']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity730 :: (MESH:D002114,Disease) :: ['aortic root calcification']


abstract: PURPOSE: To investigate the association between @entity730 ( @entity730 ) and @entity729 ( @entity729 ) assessed by coronary artery @entity460 -scoring dual-source computed tomography (DSCT). MATERIALS AND METHODS: We retrospectively analyzed 143 consecutive @entity1 who underwent coronary artery @entity460 -scoring during coronary DSCT angiography. 57 @entity1 had findings of @entity730 on @entity460 -scoring scans. @entity730 volume (ARCV) and Agatston coronary artery @entity460 score (CACS) were calculated. Chi-square test was used to assess differences of categorical variables between @entity1 with and without @entity730 . Statistical significances between both groups were assessed with the independent-Sample t test. RESULTS: Compared with @entity1 without @entity730 (n=86), @entity1 with @entity730 (n=57) showed a significantly higher presence of @entity729 (87.7% vs. 24.4%; P<0.001), and a higher mean CACS (700.6  941.2 vs. 256.4  724.3; P=0.009) in @entity1 with @entity729 . @entity1 with a calculated ARCV >40mm(3) (n=32) showed significantly higher rates of severe @entity729 (56.3% vs. 24.0%; P=0.014) compared with @entity1 with an ARCV<40mm(3) (n=25). Compared with @entity1 without @entity729 (n=42), @entity1 with @entity729 (n=101) showed a significantly higher presence of @entity730 (83.3% vs. 50.5%; P<0.001) and a higher mean ARCV (95.4  116.2mm(3) vs. 29.7  33.0 mm(3); P=0.003). Severe @entity729 (n=24) correlated with an increased mean ARCV (122.3  148.8mm(3)) compared to @entity1 with minimal to moderate @entity729 (n=33, mean ARCV: 61.9  64.8mm(3); P<0.05). CONCLUSIONS: The extent of @entity730 is directly associated with the presence and degree of @entity729 on @entity460 -scoring scans during coronary DSCT angiography.

title: Association of @entity730 severity with the extent of @entity729 assessed by XXXX -scoring dual-source computed tomography.

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: PURPOSE: To investigate the association between @entity730 ( @entity730 ) and @entity729 ( @entity729 ) assessed by coronary artery @entity460 -scoring dual-source computed tomography (DSCT). MATERIALS AND METHODS: We retrospectively analyzed 143 consecutive @entity1 who underwent coronary artery @entity460 -scoring during coronary DSCT angiography. 57 @entity1 had findings of @entity730 on @entity460 -scoring scans. @entity730 volume (ARCV) and Agatston coronary artery @entity460 score (CACS) were calculated. Chi-square test was used to assess differences of categorical variables between @entity1 with and without @entity730 . Statistical significances between both groups were assessed with the independent-Sample t test. RESULTS: Compared with @entity1 without @entity730 (n=86), @entity1 with @entity730 (n=57) showed a significantly higher presence of @entity729 (87.7% vs. 24.4%; P<0.001), and a higher mean CACS (700.6  941.2 vs. 256.4  724.3; P=0.009) in @entity1 with @entity729 . @entity1 with a calculated ARCV >40mm(3) (n=32) showed significantly higher rates of severe @entity729 (56.3% vs. 24.0%; P=0.014) compared with @entity1 with an ARCV<40mm(3) (n=25). Compared with @entity1 without @entity729 (n=42), @entity1 with @entity729 (n=101) showed a significantly higher presence of @entity730 (83.3% vs. 50.5%; P<0.001) and a higher mean ARCV (95.4  116.2mm(3) vs. 29.7  33.0 mm(3); P=0.003). Severe @entity729 (n=24) correlated with an increased mean ARCV (122.3  148.8mm(3)) compared to @entity1 with minimal to moderate @entity729 (n=33, mean ARCV: 61.9  64.8mm(3); P<0.05). CONCLUSIONS: The extent of @entity730 is directly associated with the presence and degree of @entity729 on @entity460 -scoring scans during coronary DSCT angiography.

title: Association of @entity730 severity with the extent of XXXX assessed by @entity460 -scoring dual-source computed tomography.

answer: @entity729 :: (MESH:D061205,Disease) :: ['coronary artery calcification']


abstract: UNASSIGNED: @entity1 telomeres are G-rich tandem repeats that assume G-quadruplex structures at the ends of chromosomes. Stabilization of telomeric G-quadruplex represents a significant drug target for inhibiting the telomerase activity that is required in ~85% of @entity5 . Metal ions have been revealed as important stabilizers to DNA G-quadruplexes, but their binding process with @entity1 telomeric G-quadruplex remains unclear. In this report, we show that @entity3529 traverses into the G-tetrads center of two G-tetrad layers through the half-capped top pathway constructed by the two edge-wise loop bases. The binding is mediated by the electrostatic interactions between @entity3529 and the nearby bases of G-tetrads. However, direct traverse of @entity3529 into the interior of G-quadruplex is negatively regulated by the steric hindrance of water molecules. Once @entity3529 enters the G-quadruplex, stabilization of the in-plane or sandwiched conformation of the telomeric G-quadruplex- @entity3529 complex is maintained by surrounding water molecules. These findings provide insights into the atomic interactions between @entity3529 and telomere G-tetrads for targeted drug design. This article is protected by copyright. All rights reserved.

title: Characterization of potassium binding with XXXX telomeres.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: Ixeris dentata Nakai has been used for the treatment of mithridatism, calculous, indigestion, @entity55 , @entity99 , and @entity5 in Korea, China, and Japan. However, the effect of a water extract of Ixeris dentata (ID) and its molecular mechanism on @entity32 has not been elucidated. In this study, we attempted to evaluate the effects of ID and its major compound @entity14627 on @entity32 in vivo and in vitro. METHODS: ID was applied to @entity18580 (DNFB)-induced @entity483 ( @entity483 )-like @entity272 @entity19 and immune cell infiltration, cytokine production, and the activation of mitogen-activated protein kinases (MAPKs) were investigated. Moreover, the effect of ID on compound 48/80-induced anaphylactic shock was investigated in a @entity19 model. The @entity1 keratinocyte cell line (HaCaT cells) and @entity1 mast cells (HMC-1) were treated with ID or @entity14627 to investigate the effects on the production of chemokines and proinflammatory cytokines and on the activation of MAPKs. RESULTS: ID inhibited the serum levels of IgE and interleukin (IL)-1b in DNFB-induced @entity483 -like @entity272 @entity19 models and suppressed anaphylactic shock in the @entity19 models. ID and @entity14627 inhibited the production of chemokines and adhesion molecules in HaCaT cells. In addition, ID reduced the release of @entity5 @entity39 factor-a and @entity3806 via the inhibition of MAPKs phosphorylation in HMC-1 cells. CONCLUSIONS: These results suggest that ID is a potential therapeutic agent for allergic inflammatory diseases, including @entity1909 .

title: Effects of Ixeris dentata water extract and XXXX on @entity32 in vivo and in vitro.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['allergic inflammation']

entities_list: @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis', 'AD']

entities_list: @entity18580 :: ('CHEBI:53049', 'Chemical') :: ['2, 4-dinitrofluorobenzene']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity14627 :: ('MESH:C040048', 'Chemical') :: ['caffeic acid']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesion']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatitis']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['dermatitis']

answer: @entity14627 :: (MESH:C040048,Chemical) :: ['caffeic acid']


abstract: BACKGROUND: Ixeris dentata Nakai has been used for the treatment of mithridatism, calculous, indigestion, @entity55 , @entity99 , and @entity5 in Korea, China, and Japan. However, the effect of a water extract of Ixeris dentata (ID) and its molecular mechanism on @entity32 has not been elucidated. In this study, we attempted to evaluate the effects of ID and its major compound @entity14627 on @entity32 in vivo and in vitro. METHODS: ID was applied to @entity18580 (DNFB)-induced @entity483 ( @entity483 )-like @entity272 @entity19 and immune cell infiltration, cytokine production, and the activation of mitogen-activated protein kinases (MAPKs) were investigated. Moreover, the effect of ID on compound 48/80-induced anaphylactic shock was investigated in a @entity19 model. The @entity1 keratinocyte cell line (HaCaT cells) and @entity1 mast cells (HMC-1) were treated with ID or @entity14627 to investigate the effects on the production of chemokines and proinflammatory cytokines and on the activation of MAPKs. RESULTS: ID inhibited the serum levels of IgE and interleukin (IL)-1b in DNFB-induced @entity483 -like @entity272 @entity19 models and suppressed anaphylactic shock in the @entity19 models. ID and @entity14627 inhibited the production of chemokines and adhesion molecules in HaCaT cells. In addition, ID reduced the release of @entity5 @entity39 factor-a and @entity3806 via the inhibition of MAPKs phosphorylation in HMC-1 cells. CONCLUSIONS: These results suggest that ID is a potential therapeutic agent for allergic inflammatory diseases, including @entity1909 .

title: Effects of Ixeris dentata water extract and @entity14627 on XXXX in vivo and in vitro.

answer: @entity32 :: (MESH:D007249,Disease) :: ['allergic inflammation']


abstract: BACKGROUND: Defining the threshold for therapeutic and surgical intervention in @entity1 with @entity9042 presents a considerable challenge given the lack of clear, evidence-based data. Little is known about the patterns of practice and referral criteria of optometrists within Australia. METHODS: All members of the NSW branch of Optometrist Association Australia were invited to complete an online survey in January 2013. This survey was designed to elicit practice information regarding the evaluation and therapeutic treatment of @entity1 with @entity9042 in the optometric setting. RESULTS: Responses were received from 71 optometrists, of whom 65.2 per cent had 15 years or greater experience as an optometrist. Many (35.4 per cent) responded that they prescribed soft contact lenses daily. This percentage dropped to 9.2 per cent for rigid gas-permeable lenses (RGP), although 47.7 per cent said they would prescribe RGP lenses at least once per month. The main barriers to prescribing were experience with fitting RGP lenses, time and low market demand. In terms of @entity1 referral to an ophthalmologist, the results were variable, with 34.4 per cent stating that they would refer on progression of corneal signs, 23.4 per cent suggesting no set time and 7.8 per cent would refer on initial diagnosis. Many optometrists (62.9 per cent) would refer a @entity1 for possible surgery, when visual acuity dropped to between 6/9 and 6/12. The size or location of the practice was not associated with the number of newly diagnosed cases of @entity9042 . Optometrists with greater experience were more likely to prescribe RGP lenses and co-manage @entity1 with ophthalmologists. Ownership of a corneal topographic unit suggested an increased likelihood of prescribing RGP lenses but did not appear to alter referral patterns. CONCLUSION: Optometrists have an integral role in the diagnosis and management of @entity1 with @entity9042 . Our survey provides a basic snapshot of current, local practice. Additionally, ophthalmology should continue to work with optometry to develop guidelines for referral and co-management to optimise future outcomes for our @entity1 .

title: Therapeutic treatment of XXXX : a survey of local optometric practice criteria.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity9042 :: ('MESH:D007640', 'Disease') :: ['keratoconus']

answer: @entity9042 :: (MESH:D007640,Disease) :: ['keratoconus']


abstract: BACKGROUND: Functional and morphological @entity8 have been widely described in @entity1201 for decades. Nevertheless few studies have assessed renal function pre- and during treatment after the advent of @entity6371 ( @entity6371 ). METHODS: This is a prospective study involving 189 consecutive @entity1 , with all forms of @entity1201 (Ridley-Jopling scale). Laboratory (serum @entity1133 and @entity1011 , estimated GFR, urinalysis, microalbuminuria, urinary @entity19845 ) and clinical features of @entity8 were evaluated previously and after onset (3 and 8 months later) of @entity6371 . RESULTS: One hundred and eighty-nine @entity1 (M 1.8: F 1; mean age 44        16 years) were included just after diagnosis of @entity1201 and before the introduction of @entity6371 . Mean time until manifestation of symptoms and/or signs of @entity1201 was 29        56 months (25 days-480 months). Microhematuria and microalbuminuria were detected in 7.5% and 9.6% of the cases, respectively. Elevated serum @entity1011 was detected in 34% pre- @entity6371 ; this was statistically more frequent in males, @entity101 and frequent users of non-steroidal anti-inflammatory drugs (NSAID), as well as in @entity1 with @entity5406 , 45.5% by the time of diagnosis, 18% after 3 months and 9% after 8 months of @entity6371 (p   =   0.039). CONCLUSIONS: Our results suggest that functional @entity8 in @entity1201 are currently mild and predominantly of glomerular origin, in opposition to the severe involvement described in the past. This improved outcome of @entity8 secondary to @entity1201 is possibly due to the advent of @entity6371 and effective treatment of episodes of reaction, leading to shorter periods of active @entity166 .

title: It is time to review concepts on renal involvement in XXXX : pre- and post-treatment evaluation of 189 @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal lesions', 'renal disease']

entities_list: @entity6371 :: ('MESH:D018088', 'Disease') :: ['multidrug therapy', 'MDT']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious disease']

entities_list: @entity5406 :: ('MESH:D004893', 'Disease') :: ['erythema nodosum lepromatosum']

answer: @entity1201 :: (MESH:D007918,Disease) :: ['leprosy']


abstract: BACKGROUND: Functional and morphological @entity8 have been widely described in @entity1201 for decades. Nevertheless few studies have assessed renal function pre- and during treatment after the advent of @entity6371 ( @entity6371 ). METHODS: This is a prospective study involving 189 consecutive @entity1 , with all forms of @entity1201 (Ridley-Jopling scale). Laboratory (serum @entity1133 and @entity1011 , estimated GFR, urinalysis, microalbuminuria, urinary @entity19845 ) and clinical features of @entity8 were evaluated previously and after onset (3 and 8 months later) of @entity6371 . RESULTS: One hundred and eighty-nine @entity1 (M 1.8: F 1; mean age 44        16 years) were included just after diagnosis of @entity1201 and before the introduction of @entity6371 . Mean time until manifestation of symptoms and/or signs of @entity1201 was 29        56 months (25 days-480 months). Microhematuria and microalbuminuria were detected in 7.5% and 9.6% of the cases, respectively. Elevated serum @entity1011 was detected in 34% pre- @entity6371 ; this was statistically more frequent in males, @entity101 and frequent users of non-steroidal anti-inflammatory drugs (NSAID), as well as in @entity1 with @entity5406 , 45.5% by the time of diagnosis, 18% after 3 months and 9% after 8 months of @entity6371 (p   =   0.039). CONCLUSIONS: Our results suggest that functional @entity8 in @entity1201 are currently mild and predominantly of glomerular origin, in opposition to the severe involvement described in the past. This improved outcome of @entity8 secondary to @entity1201 is possibly due to the advent of @entity6371 and effective treatment of episodes of reaction, leading to shorter periods of active @entity166 .

title: It is time to review concepts on renal involvement in @entity1201 : pre- and post-treatment evaluation of 189 XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Entities of @entity75 comprise almost inflammatory and lymphoproliferative processes as well as benign and malignant solid @entity5 and usually cannot be differentiated by magnetic resonance imaging (MRI) exclusively. Hence, representative tissue samples are needed to arrive at sufficient histopathological diagnosis for further treatment decisions. CASE REPORT: Three @entity1 aged between 18 and 67  years were admitted to our center with clinical signs of a space-occupying mass in the lacrimal fossa. MRI revealed a circumscribed lacrimal gland lesion in all three cases. The orbital lobe was resected through a lateral orbitotomy approach for histopathological evaluation. Findings confirmed the diagnoses of @entity5123 , @entity4578 , and low-grade B cell @entity1893 . Further surgery was not necessary. No recurrence or symptoms of " @entity936 " were observed over the course of a 1-year follow-up. CONCLUSION: In cases of non-specific masses in the lacrimal gland on MRI, histopathological diagnoses are vital and can be sufficiently provided by resection of the orbital lobe. Symptoms of @entity936 are uncommon, and secondary surgical intervention can be avoided in cases of the presented entities. Further studies with larger @entity1 cohorts are warranted to confirm these findings.

title: Orbital lobe resection provides a definite diagnosis of XXXX : a report of three cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient']

entities_list: @entity5123 :: ('MESH:D008949', 'Disease') :: ['pleomorphic adenoma']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['lacrimal gland lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]

entities_list: @entity4578 :: ('MESH:D003607', 'Disease') :: ['dacryoadenitis']

answer: @entity75 :: (MESH:D001927,Disease) :: ['lacrimal gland lesions']


abstract: PURPOSE: The available literature on the treatment options for recurrent or metastatic @entity1204 ( @entity1204 ) is full of controversies. Therefore, we explore the results of the AGO pattern of care studies from the years 2013, 2009 and 2006. METHODS: A questionnaire was developed and sent to all 682 German gynecological departments in 2013 (775 in 2009, 500 in 2006, respectively). The results of the questionnaires were compared with each other using Fisher's exact test. RESULTS: Responses were available in 40.0  % in 2013, 33.3  % in 2009 and 35.8  % in 2006. In 2013 the most preferred endocrine drug was progestin (79.8  %), followed by @entity440 (42.8  %), aromatase inhibitor (19.8  %), @entity1299 (16.3  %) and a combination (3.9  %) (p  <  0.001). 65.3, 59.8, 51.7 and 38.2  % of the @entity1 used @entity902 , @entity3907 , a combination of cytostatic drugs, @entity5948 in metastatic @entity1204 , respectively (p  =  0.215). 96.2, 92.7, 49.8 and 60.9  % of the @entity1 performed an operation, radiotherapy, endocrine therapy and chemotherapy in 2013 because of a local recurrence, respectively (p  <  0.001). Compared to 2009 and 2006 these rates remained stable (no p value <0.05). Because of a distant metastasis 50.4, 64.2, 78.5 and 90.8  % of the @entity1 performed an operation, radiotherapy, endocrine therapy and chemotherapy in 2013, respectively (p  <  0.001). Compared to 2009 and 2006 more @entity1 performed an operation or radiotherapy and less an endocrine treatment. CONCLUSIONS: Whereas @entity1871 was the favorite drug, the @entity1 of this study did not prefer a specific cytostatic drug for metastatic @entity1204 in 2013. This might have reflected the available literature, which did not provide a real standard of care.

title: Management of recurrent or metastatic XXXX in Germany: results of the nationwide AGO pattern of care studies from the years 2013, 2009 and 2006.

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer', 'EC']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['tamoxifen']

entities_list: @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline']

entities_list: @entity1871 :: ('CHEBI:59826', 'Chemical') :: ['progestin']

entities_list: @entity1299 :: ('MESH:C070081', 'Chemical') :: ['fulvestrant']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial cancer']


abstract: The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a corresponding elaboration in cortical @entity935 (DA). DA cells that fire to both aversive and rewarding stimuli likely project to the dorsolateral PFC (dlPFC), signaling a salient event. Since 1979, we have known that DA has an essential influence on dlPFC working memory functions. DA has differing effects via D1 (D1R) versus @entity1633 ( @entity1633 ) families. D1R are concentrated on dendritic spines, and D1/5R stimulation produces an inverted U-shaped dose response on visuospatial working memory performance and Delay cell firing, the neurons that generate representations of visual space. Optimal levels of D1R stimulation gate out "noise," whereas higher levels, e.g., during stress, suppress Delay cell firing. These effects likely involve hyperpolarization-activated @entity8614 -gated channel opening, activation of @entity1246 interneurons, and reduced @entity3264 release. Dysregulation of D1R has been related to @entity73 in @entity161 , and there is a need for new, lower-affinity D1R agonists that may better mimic endogenous DA to enhance mental representations and improve cognition. In contrast to D1R, @entity1633 are primarily localized on layer V pyramidal cell dendrites, and D2/3R stimulation speeds and magnifies the firing of Response cells, including Response Feedback cells. Altered firing of Feedback neurons may relate to positive symptoms in @entity161 . Emerging research suggests that DA may have similar effects in the ventrolateral PFC and frontal eye fields. Research on the orbital PFC in monkeys is just beginning and could be a key area for future discoveries.

title: XXXX 's Actions in Primate Prefrontal Cortex: Challenges for Treating @entity73 .

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits']

entities_list: @entity8614 :: ('D009712', 'Chemical') :: ['cyclic nucleotide']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity935 :: (MESH:D004298,Chemical) :: ['Dopamine']


abstract: The prefrontal cortex (PFC) elaborates and differentiates in primates, and there is a corresponding elaboration in cortical @entity935 (DA). DA cells that fire to both aversive and rewarding stimuli likely project to the dorsolateral PFC (dlPFC), signaling a salient event. Since 1979, we have known that DA has an essential influence on dlPFC working memory functions. DA has differing effects via D1 (D1R) versus @entity1633 ( @entity1633 ) families. D1R are concentrated on dendritic spines, and D1/5R stimulation produces an inverted U-shaped dose response on visuospatial working memory performance and Delay cell firing, the neurons that generate representations of visual space. Optimal levels of D1R stimulation gate out "noise," whereas higher levels, e.g., during stress, suppress Delay cell firing. These effects likely involve hyperpolarization-activated @entity8614 -gated channel opening, activation of @entity1246 interneurons, and reduced @entity3264 release. Dysregulation of D1R has been related to @entity73 in @entity161 , and there is a need for new, lower-affinity D1R agonists that may better mimic endogenous DA to enhance mental representations and improve cognition. In contrast to D1R, @entity1633 are primarily localized on layer V pyramidal cell dendrites, and D2/3R stimulation speeds and magnifies the firing of Response cells, including Response Feedback cells. Altered firing of Feedback neurons may relate to positive symptoms in @entity161 . Emerging research suggests that DA may have similar effects in the ventrolateral PFC and frontal eye fields. Research on the orbital PFC in monkeys is just beginning and could be a key area for future discoveries.

title: @entity935 's Actions in Primate Prefrontal Cortex: Challenges for Treating XXXX .

answer: @entity73 :: (MESH:D003072,Disease) :: ['Cognitive Disorders']


abstract: OBJECTIVE: Coexistence of @entity19417 ( @entity19417 ) and @entity8787 is a rare condition that is rarely described in the literature. The aim of the study was to describe the main characteristics of @entity1 presenting with both @entity8787 and @entity19417 . METHODS: A retrospective study of @entity19417 @entity1 in the @entity1333 Study Group cohort who also had a diagnosis of @entity8787 was conducted. We reviewed the medical records and outcomes of these @entity1 . RESULTS: We identified 11 @entity1 with @entity19417 and @entity8787 . Four @entity1 with eosinophilic @entity2883 with @entity2883 ( @entity12534 ) also had @entity31 and seven @entity1 with @entity2883 with @entity2883 (GPA) had @entity30 . No @entity30 was observed in eosinophilic GPA and no @entity31 in GPA. @entity8787 started before @entity19417 manifestations in six cases, simultaneously in two cases and after @entity19417 manifestations in three cases. CONCLUSION: Coexistence of @entity8787 and @entity19417 is a rare condition. The therapeutic management of these @entity1 includes corticosteroids in all cases and immunosuppressive drugs in some @entity1 . Coexistence of @entity8787 and @entity19417 might be explained by common underlying inflammatory responses and cytokine profiles polarized towards either @entity1198 or Th2. Finally, in the presence of digestive manifestations in the context of @entity19417 , the hypothesis of @entity8787 should be assessed.

title: Inflammatory bowel diseases in anti-neutrophil cytoplasmic antibody-associated vasculitides: 11 retrospective cases from the XXXX Study Group.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1333 :: ('MESH:D014657', 'Disease') :: ['French Vasculitis']

entities_list: @entity12534 :: ('MESH:D015267', 'Disease') :: ['Churg-Strauss']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis']

entities_list: @entity2883 :: ('MESH:D014890', 'Disease') :: ['polyangiitis', 'granulomatosis']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

entities_list: @entity19417 :: ('MESH:D056648', 'Disease') :: ['AAV', 'ANCA-associated vasculitis']

answer: @entity1333 :: (MESH:D014657,Disease) :: ['French Vasculitis']


abstract: Following elective total hip replacement, both continuous lumbar plexus blockade and spinal anaesthesia (with adjunctive intrathecal @entity1286 ) have shown early outcome benefits over opioid @entity1337 and single-injection nerve block. However, the two techniques have not been compared in a prospective randomised manner. Our study examined 50 @entity1 undergoing elective hip joint replacement who were randomised to receive spinal anaesthesia (with adjunctive intrathecal @entity1286 0.1 mg) or @entity1 -controlled continuous lumbar plexus blockade. All surgery was conducted under general anaesthesia. Measured outcomes included numerically rated @entity282 , @entity4784 and indices of mobilisation together with complications. Results show that block placement time was marginally shorter for the spinal group (5 versus 7 minutes, P=0.01). The primary outcome, @entity158 on movement/mobilisation during the first 24 hours, was not statistically significantly different between groups. @entity1 in the lumbar plexus group were given more intraoperative opioid and rescue @entity1286 in the post-anaesthesia care unit (median = 4 versus 0 mg, P <0.001), with correspondingly higher @entity158 scores (median 5/10 versus 0/10, P <0.001). @entity158 scores during the subsequent 24 hours were similar between groups, but more @entity1 in the spinal group were given rescue @entity1286 (5 versus 0, P=0.02). Physiotherapy mobilisation indices appeared similar between groups. More spinal group @entity1 reported @entity111 (12 versus 5, P=0.01), but antiemetic requirements, episodes of disorientation, arterial @entity26 desaturation and falls were all similar between groups. Postoperative symptoms suggestive of @entity16 or injury did not differ between groups. We found that following elective hip joint replacement, compared to continuous lumbar plexus blockade, spinal anaesthesia incorporating adjunctive intrathecal @entity1286 did not result in a statistically significant difference in @entity158 on movement/mobilisation during the first 24 hours, although it was associated with better @entity1337 in the post-anaesthesia care unit. Subsequently, however, these @entity1 appeared to require more rescue @entity1286 and more of them reported @entity111 .

title: Spinal anaesthesia with adjunctive intrathecal @entity1286 versus continuous lumbar plexus blockade: a randomised comparison for XXXX after hip replacement.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity4784 :: ('MESH:D009293', 'Disease') :: ['supplemental opioid consumption']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological irritation']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['morphine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain', 'worst pain']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

answer: @entity1337 :: (MESH:D000699,Disease) :: ['analgesia']


abstract: Following elective total hip replacement, both continuous lumbar plexus blockade and spinal anaesthesia (with adjunctive intrathecal @entity1286 ) have shown early outcome benefits over opioid @entity1337 and single-injection nerve block. However, the two techniques have not been compared in a prospective randomised manner. Our study examined 50 @entity1 undergoing elective hip joint replacement who were randomised to receive spinal anaesthesia (with adjunctive intrathecal @entity1286 0.1 mg) or @entity1 -controlled continuous lumbar plexus blockade. All surgery was conducted under general anaesthesia. Measured outcomes included numerically rated @entity282 , @entity4784 and indices of mobilisation together with complications. Results show that block placement time was marginally shorter for the spinal group (5 versus 7 minutes, P=0.01). The primary outcome, @entity158 on movement/mobilisation during the first 24 hours, was not statistically significantly different between groups. @entity1 in the lumbar plexus group were given more intraoperative opioid and rescue @entity1286 in the post-anaesthesia care unit (median = 4 versus 0 mg, P <0.001), with correspondingly higher @entity158 scores (median 5/10 versus 0/10, P <0.001). @entity158 scores during the subsequent 24 hours were similar between groups, but more @entity1 in the spinal group were given rescue @entity1286 (5 versus 0, P=0.02). Physiotherapy mobilisation indices appeared similar between groups. More spinal group @entity1 reported @entity111 (12 versus 5, P=0.01), but antiemetic requirements, episodes of disorientation, arterial @entity26 desaturation and falls were all similar between groups. Postoperative symptoms suggestive of @entity16 or injury did not differ between groups. We found that following elective hip joint replacement, compared to continuous lumbar plexus blockade, spinal anaesthesia incorporating adjunctive intrathecal @entity1286 did not result in a statistically significant difference in @entity158 on movement/mobilisation during the first 24 hours, although it was associated with better @entity1337 in the post-anaesthesia care unit. Subsequently, however, these @entity1 appeared to require more rescue @entity1286 and more of them reported @entity111 .

title: Spinal anaesthesia with adjunctive intrathecal XXXX versus continuous lumbar plexus blockade: a randomised comparison for @entity1337 after hip replacement.

answer: @entity1286 :: (MESH:D009020,Chemical) :: ['morphine']


abstract: UNASSIGNED: Stress has been shown to affect the immune system of @entity233 making them more susceptible to @entity2348 . Five-week-old male and female @entity233 were treated with 3 intra-muscular injections of @entity619 ( @entity9170 ) at 0, 0.5 and 2.0mg/kg body weight. Twenty-four hours after the third injection birds were bled and white blood cell (WBC) differentials and bacteriostatic activity of monocytes were measured. @entity9170 at both 0.5 and 2.0mg/kg decreased phagocytic activity in females only. Bacteriostatic activity was decreased at both concentrations of @entity9170 at 8 and 16h post-infection in both sexes and was lower in males as compared to females. Total WBC counts were increased in females at both concentrations of @entity9170 whereas male total WBC counts were unaffected. Both males and females had an increase in the heterophil to lymphocyte ratio. Within the same study, replicate pens of @entity233 were challenged with intra-air sac inoculation of 100cfu of @entity526 . Isolation of @entity526 was significantly increased by both @entity9170 and @entity526 challenge, but there were no differences between sexes. These results suggest that stress can compromise the bacteriostatic activity of @entity233 monocytes and increase bacterial colonization of blood and tissues, potentially affecting food safety.

title: Effect of @entity619 on bacteriostatic activity of XXXX monocytes and implications for food safety.

entities_list: @entity233 :: ('9103', 'Species') :: ['turkey', 'turkeys']

entities_list: @entity2348 :: ('MESH:D001424', 'Disease') :: ['bacterial infections']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity233 :: (9103,Species) :: ['turkey']


abstract: UNASSIGNED: Stress has been shown to affect the immune system of @entity233 making them more susceptible to @entity2348 . Five-week-old male and female @entity233 were treated with 3 intra-muscular injections of @entity619 ( @entity9170 ) at 0, 0.5 and 2.0mg/kg body weight. Twenty-four hours after the third injection birds were bled and white blood cell (WBC) differentials and bacteriostatic activity of monocytes were measured. @entity9170 at both 0.5 and 2.0mg/kg decreased phagocytic activity in females only. Bacteriostatic activity was decreased at both concentrations of @entity9170 at 8 and 16h post-infection in both sexes and was lower in males as compared to females. Total WBC counts were increased in females at both concentrations of @entity9170 whereas male total WBC counts were unaffected. Both males and females had an increase in the heterophil to lymphocyte ratio. Within the same study, replicate pens of @entity233 were challenged with intra-air sac inoculation of 100cfu of @entity526 . Isolation of @entity526 was significantly increased by both @entity9170 and @entity526 challenge, but there were no differences between sexes. These results suggest that stress can compromise the bacteriostatic activity of @entity233 monocytes and increase bacterial colonization of blood and tissues, potentially affecting food safety.

title: Effect of XXXX on bacteriostatic activity of @entity233 monocytes and implications for food safety.

answer: @entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']


abstract: AIMS: Due to the paucity of studies focusing on primary @entity631 , the second commonest cause of @entity454 in most of the developed world, we sought to review outcomes of these renal pathologies. METHODS: We reviewed outcomes of primary @entity631 in @entity1 enrolled in the New Zealand @entity631 Study between 1972 and 1983 focusing on renal outcomes and mortality. RESULTS: There were 765 @entity1 with a median follow-up of 30 years (range 0  1- 42years). They were predominantly New Zealand European, male and @entity101 . Poor renal outcomes and increased mortality were associated with @entity101 , @entity644 greater than 1g/day, reduced estimated glomerular filtration rate and older age at diagnosis. Ethnicity was not significantly associated with progression to @entity454 although indigenous NZ Maori @entity1 were at significantly increased risk of @entity204 . @entity1 diagnosed with rapidly progressive @entity631 were 5 times more likely than those with minimal change @entity8 to reach @entity454 . The cumulative incidence of @entity454 was approximately 20% for those with immunoglobulin-A @entity8 , and 30% @entity8 @entity1 . @entity1 with rapidly progressive @entity631 and @entity8 were at increased risk of @entity204 , although the latter were not at increased risk of @entity454 if they survived. The era of diagnosis did not have much effect on outcomes except for @entity1 diagnosed with @entity628 or immunoglobulin A @entity8 but this could be type II error. CONCLUSION: We report one of the longest follow-up studies on biopsy-proven @entity631 . Age, @entity101 , and severity of @entity740 at diagnosis were strong predictors of the development of @entity454 and @entity204 . The specific renal pathology had a profound impact upon prognosis and therefore should continue to drive efforts to find targeted therapeutic options for these @entity631 .

title: Long-term outcomes for primary @entity631 : New Zealand XXXX study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['nephropathy', 'membranous nephropathy', 'anti-glomerular basement membrane disease']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity628 :: ('MESH:D005923', 'Disease') :: ['focal segmental glomerulosclerosis']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritides', 'Glomerulonephritis', 'glomerulonephritis']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage-kidney-disease']

answer: @entity631 :: (MESH:D005921,Disease) :: ['Glomerulonephritis']


abstract: AIMS: Due to the paucity of studies focusing on primary @entity631 , the second commonest cause of @entity454 in most of the developed world, we sought to review outcomes of these renal pathologies. METHODS: We reviewed outcomes of primary @entity631 in @entity1 enrolled in the New Zealand @entity631 Study between 1972 and 1983 focusing on renal outcomes and mortality. RESULTS: There were 765 @entity1 with a median follow-up of 30 years (range 0  1- 42years). They were predominantly New Zealand European, male and @entity101 . Poor renal outcomes and increased mortality were associated with @entity101 , @entity644 greater than 1g/day, reduced estimated glomerular filtration rate and older age at diagnosis. Ethnicity was not significantly associated with progression to @entity454 although indigenous NZ Maori @entity1 were at significantly increased risk of @entity204 . @entity1 diagnosed with rapidly progressive @entity631 were 5 times more likely than those with minimal change @entity8 to reach @entity454 . The cumulative incidence of @entity454 was approximately 20% for those with immunoglobulin-A @entity8 , and 30% @entity8 @entity1 . @entity1 with rapidly progressive @entity631 and @entity8 were at increased risk of @entity204 , although the latter were not at increased risk of @entity454 if they survived. The era of diagnosis did not have much effect on outcomes except for @entity1 diagnosed with @entity628 or immunoglobulin A @entity8 but this could be type II error. CONCLUSION: We report one of the longest follow-up studies on biopsy-proven @entity631 . Age, @entity101 , and severity of @entity740 at diagnosis were strong predictors of the development of @entity454 and @entity204 . The specific renal pathology had a profound impact upon prognosis and therefore should continue to drive efforts to find targeted therapeutic options for these @entity631 .

title: Long-term outcomes for primary XXXX : New Zealand @entity631 study.

answer: @entity631 :: (MESH:D005921,Disease) :: ['glomerulonephritis']


abstract: IMPORTANCE: @entity737 ( @entity737 ) are not recommended within 40 days of @entity583 ( @entity583 ); thus, @entity1479 implantation might not be considered during the post- @entity583 care transition. OBJECTIVE: To examine @entity1479 implantation rates and associated mortality among older @entity583 @entity1 with low ejection fraction (EF). DESIGN, SETTING, AND @entity1 : Retrospective observational study of Medicare beneficiaries with an EF of 35% or less after @entity583 , treated at 441 US hospitals between 2007 and 2010, excluding @entity1 with prior @entity1479 implantation. Follow-up data were available through December 2010. EXPOSURES: @entity1479 implantation within 1 year of @entity583 vs no @entity1479 implantation within 1 year of @entity583 . MAIN OUTCOMES AND MEASURES: @entity1 characteristics associated with receiving an @entity1479 within 1 year after discharge and 2-year mortality associated with @entity1479 implantation. RESULTS: Among 10,318 @entity583 @entity1 with EF of 35%or lower, the cumulative 1-year @entity1479 implantation rate was 8.1% (95%CI, 7.6%-8.7%). @entity1 with @entity1479 implantation were more likely to have prior coronary artery bypass graft procedures, higher peak troponin levels, in-hospital @entity1455 , and cardiology follow-up within 2 weeks after discharge relative to @entity1 who did not receive an @entity1479 within 1 year. Implantation of @entity1479 was associated with lower 2-year mortality (15.3 events per 100 @entity1 -years [128 deaths in 838 @entity1 -years] vs 26.4 events per 100 @entity1 -years [3033 deaths in 11 479 @entity1 -years]; adjusted HR, 0.64; 95%CI, 0.53-0.78). [table: see text] CONCLUSIONS AND RELEVANCE: In this large registry study of older @entity1 who experienced @entity583 from 2007-2010, fewer than 1 in 10 eligible @entity1 with low EF received an @entity1479 within 1 year after @entity583 , although @entity1479 implantation was associated with lower risk-adjusted mortality at 2 years. Additional research is needed to determine evidence-based approaches to increase @entity1479 implantation among eligible @entity1 .

title: Implantable Cardioverter-Defibrillator Use Among Medicare @entity1 With Low Ejection Fraction After Acute XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient', 'PARTICIPANTS']

entities_list: @entity737 :: ('MESH:D057873', 'Disease') :: ['Implantable cardioverter-defibrillators', 'ICDs']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

answer: @entity583 :: (MESH:D009203,Disease) :: ['Myocardial Infarction']


abstract: IMPORTANCE: @entity737 ( @entity737 ) are not recommended within 40 days of @entity583 ( @entity583 ); thus, @entity1479 implantation might not be considered during the post- @entity583 care transition. OBJECTIVE: To examine @entity1479 implantation rates and associated mortality among older @entity583 @entity1 with low ejection fraction (EF). DESIGN, SETTING, AND @entity1 : Retrospective observational study of Medicare beneficiaries with an EF of 35% or less after @entity583 , treated at 441 US hospitals between 2007 and 2010, excluding @entity1 with prior @entity1479 implantation. Follow-up data were available through December 2010. EXPOSURES: @entity1479 implantation within 1 year of @entity583 vs no @entity1479 implantation within 1 year of @entity583 . MAIN OUTCOMES AND MEASURES: @entity1 characteristics associated with receiving an @entity1479 within 1 year after discharge and 2-year mortality associated with @entity1479 implantation. RESULTS: Among 10,318 @entity583 @entity1 with EF of 35%or lower, the cumulative 1-year @entity1479 implantation rate was 8.1% (95%CI, 7.6%-8.7%). @entity1 with @entity1479 implantation were more likely to have prior coronary artery bypass graft procedures, higher peak troponin levels, in-hospital @entity1455 , and cardiology follow-up within 2 weeks after discharge relative to @entity1 who did not receive an @entity1479 within 1 year. Implantation of @entity1479 was associated with lower 2-year mortality (15.3 events per 100 @entity1 -years [128 deaths in 838 @entity1 -years] vs 26.4 events per 100 @entity1 -years [3033 deaths in 11 479 @entity1 -years]; adjusted HR, 0.64; 95%CI, 0.53-0.78). [table: see text] CONCLUSIONS AND RELEVANCE: In this large registry study of older @entity1 who experienced @entity583 from 2007-2010, fewer than 1 in 10 eligible @entity1 with low EF received an @entity1479 within 1 year after @entity583 , although @entity1479 implantation was associated with lower risk-adjusted mortality at 2 years. Additional research is needed to determine evidence-based approaches to increase @entity1479 implantation among eligible @entity1 .

title: Implantable Cardioverter-Defibrillator Use Among Medicare XXXX With Low Ejection Fraction After Acute @entity583 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: @entity10591 mediates the transcription of a large number of constitutive genes encoding physiological mediators. NF-kB mediates the expression of hundreds of inducible genes encoding pathological mediators. Crosstalk between @entity10591 and NF-kB pathways could be pathophysiologically significant, but has not been studied. This study examined the crosstalk between the two pathways and defined the role of NF-kB signaling in @entity558 -induced down-regulation of @entity10591 activity. METHODS AND MAIN FINDINGS: Challenge of wild type @entity19 with samonelia enteritidis @entity558 (10 mg/kg, i.p.) down-regulated @entity10591 binding activity in lungs in a time-dependent manner, which was concomitantly associated with an increased NF-kB activity. @entity558 down-regulates @entity10591 activity by inducing an @entity558 inducible @entity10591 -degrading enzyme (LISPDE) activity, which selectively degrades @entity10591 protein, resulting in @entity10591 down-regulation. Blockade of NF-kB activation in @entity19 deficient in NF-kB p50 gene (NF-kB-KO) suppressed LISPDE activity, prevented @entity10591 protein degradation, and reversed the down-regulation of @entity10591 DNA binding activity and eNOS expression (an indicator of @entity10591 transactivation activity). Inhibition of LISPDE activity using a selective LISPDE inhibitor mimicked the effects of NF-kB blockade. Pretreatment of @entity558 -challenged WT @entity19 with a selective LISPDE inhibitor increased nuclear @entity10591 protein content, restored @entity10591 DNA binding activity and reversed eNOS protein down-regulation in lungs. Enhancing tissue level of @entity10591 activity by inhibiting NF-kB-mediated @entity10591 down-regulation increased tissue level of @entity1618 and decreased tissue level of TNF- ain the lungs. CONCLUSIONS: NF-kB signaling mediates @entity558 -induced down-regulation of @entity10591 activity. Activation of NF-kB pathway suppresses @entity10591 activity and @entity10591 -mediated anti-inflammatory signals. Conversely, @entity10591 signaling counter-regulates NF-kB-mediated inflammatory response. Crosstalk between NF-kB and @entity10591 pathways regulates the balance between pro- and anti-inflammatory cytokines.

title: XXXX Down-Regulates Specificity Protein 1 Activity by Activating NF-kB Pathway in Endotoxemic @entity19 .

answer: @entity558 :: (MESH:C536528,Disease) :: ['LPS']


abstract: BACKGROUND: @entity10591 mediates the transcription of a large number of constitutive genes encoding physiological mediators. NF-kB mediates the expression of hundreds of inducible genes encoding pathological mediators. Crosstalk between @entity10591 and NF-kB pathways could be pathophysiologically significant, but has not been studied. This study examined the crosstalk between the two pathways and defined the role of NF-kB signaling in @entity558 -induced down-regulation of @entity10591 activity. METHODS AND MAIN FINDINGS: Challenge of wild type @entity19 with samonelia enteritidis @entity558 (10 mg/kg, i.p.) down-regulated @entity10591 binding activity in lungs in a time-dependent manner, which was concomitantly associated with an increased NF-kB activity. @entity558 down-regulates @entity10591 activity by inducing an @entity558 inducible @entity10591 -degrading enzyme (LISPDE) activity, which selectively degrades @entity10591 protein, resulting in @entity10591 down-regulation. Blockade of NF-kB activation in @entity19 deficient in NF-kB p50 gene (NF-kB-KO) suppressed LISPDE activity, prevented @entity10591 protein degradation, and reversed the down-regulation of @entity10591 DNA binding activity and eNOS expression (an indicator of @entity10591 transactivation activity). Inhibition of LISPDE activity using a selective LISPDE inhibitor mimicked the effects of NF-kB blockade. Pretreatment of @entity558 -challenged WT @entity19 with a selective LISPDE inhibitor increased nuclear @entity10591 protein content, restored @entity10591 DNA binding activity and reversed eNOS protein down-regulation in lungs. Enhancing tissue level of @entity10591 activity by inhibiting NF-kB-mediated @entity10591 down-regulation increased tissue level of @entity1618 and decreased tissue level of TNF- ain the lungs. CONCLUSIONS: NF-kB signaling mediates @entity558 -induced down-regulation of @entity10591 activity. Activation of NF-kB pathway suppresses @entity10591 activity and @entity10591 -mediated anti-inflammatory signals. Conversely, @entity10591 signaling counter-regulates NF-kB-mediated inflammatory response. Crosstalk between NF-kB and @entity10591 pathways regulates the balance between pro- and anti-inflammatory cytokines.

title: @entity558 Down-Regulates Specificity Protein 1 Activity by Activating NF-kB Pathway in Endotoxemic XXXX .

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: UNASSIGNED: In order to locate @entity2 on kV projection images without internal markers, digitally reconstructed radiographs (DRRs) are created and compared with projection images. However, @entity2 always move due to respiration and their locations change on projection images while they are static on DRRs. In addition, global image intensity discrepancies exist between DRRs and projections due to their different image orientations, scattering, and noises. This adversely affects comparison accuracy. A simple but efficient comparison algorithm is reported to match imperfectly matched projection images and DRRs. The kV projection images were matched with different DRRs in two steps. Preprocessing was performed in advance to generate two sets of DRRs. The @entity5 were removed from the planning 3D CT for a single phase of planning 4D CT images using planning contours of @entity5 . DRRs of background and DRRs of @entity5 were generated separately for every projection angle. The first step was to match projection images with DRRs of background signals. This method divided global images into a matrix of small tiles and similarities were evaluated by calculating normalized cross-correlation (NCC) between corresponding tiles on projections and DRRs. The tile configuration (tile locations) was automatically optimized to keep the @entity5 within a single projection tile that had a bad matching with the corresponding DRR tile. A pixel-based linear transformation was determined by linear interpolations of tile transformation results obtained during tile matching. The background DRRs were transformed to the projection image level and subtracted from it. The resulting subtracted image now contained only the @entity5 . The second step was to register DRRs of @entity5 to the subtracted image to locate the @entity5 . This method was successfully applied to kV fluoro images (about 1000 images) acquired on a Vero (BrainLAB) for @entity5 tracking on phantom studies. Radiation opaque markers were implanted and used as ground truth for @entity5 positions. Although other organs and bony structures introduced strong signals superimposed on @entity5 at some angles, this method accurately located @entity5 on every projection over 12 gantry angles. The maximum error was less than 2.2 mm, while the total average error was less than 0.9mm. This algorithm was capable of detecting @entity5 without markers, despite strong background signals.

title: An accurate algorithm to match imperfectly matched images for XXXX detection without markers.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'dynamic tumor', 'tumors']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung tumor']


abstract: OBJECTIVE: @entity785 ( @entity785 ) is characterized by severe and often progressive @entity82 of the skin and multiple internal organs. The mechanisms responsible for these alterations remain obscure, although excessive reactive @entity26 species (ROS)-mediated oxidative stress has been implicated. @entity16228 is 1 of 7 isoforms of @entity1110 oxidase responsible for the generation of ROS. The purpose of this study was to examine @entity16228 expression in skin and cultured dermal fibroblasts from @entity785 @entity1 and to examine its regulation by @entity2533 ( @entity2533 ). METHODS: @entity16228 was assessed in normal and @entity785 skin by immunohistologic analysis and in normal and @entity785 cultured dermal fibroblasts by quantitative polymerase chain reaction analysis, fluorescence microscopy, and Western blotting. ROS levels were assessed by fluorescence measurement of @entity5568 production. Specific kinase inhibitors were used to study the @entity2533 signaling involved in @entity16228 stimulation. @entity16228 inhibition/down-regulation was induced with a selective @entity16228 small-molecule inhibitor and @entity16228 small interfering RNA (siRNA). RESULTS: In contrast with normal skin fibroblasts, those from @entity785 skin showed intense @entity16228 staining. Cultured @entity785 fibroblasts displayed increased @entity16228 expression. @entity2533 caused potent @entity16228 protein and messenger RNA stimulation in normal and @entity785 fibroblasts, which was mediated by the @entity7131   ( @entity7131  ) and @entity14877 pathways. @entity16228 knockdown in @entity785 fibroblasts reduced the production of ROS and lowered the expression of type I collagen. CONCLUSION: @entity16228 expression and production were found to be constitutively elevated in @entity785 skin and cultured @entity785 dermal fibroblasts. @entity2533 stimulated @entity16228 expression in normal and @entity785 fibroblasts through @entity7131   and @entity14877 signaling pathways. A small-molecule @entity16228 inhibitor decreased collagen and fibronectin production by normal and @entity785 fibroblasts, and @entity16228 siRNA knockdown reduced ROS and collagen production by @entity785 fibroblasts. These results demonstrate the involvement of @entity16228 in @entity785 -associated @entity82 and indicate @entity16228 inhibitors as novel therapeutic approaches for @entity785 .

title: Increased expression of NAPDH oxidase 4 in XXXX dermal fibroblasts: regulation by transforming growth factor b.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein kinase C', 'PKC']

entities_list: @entity2533 :: ('7040', 'Gene') :: ['TGFb1', 'transforming growth factor b1']

entities_list: @entity785 :: ('MESH:D012595', 'Disease') :: ['Systemic sclerosis', 'SSc']

answer: @entity785 :: (MESH:D012595,Disease) :: ['systemic sclerosis']


abstract: This experiment was conducted to identify some aspects of secondary follicle (SF) characteristics of Hexi cashmere @entity1237 at five different growing stages in one year in order and discover the expression pattern of @entity71139 in a SF cycling to provide morphological basis for studying the growth of cashmere. Ten cashmere @entity1237 of one-year old (5 males, 5 females) were included in this study. The density and activity of SF were observed and measured by making paraffin sections, the ultra-structural features of SF were studied under transmission electron microscopy (TEM) by making ultra-thin sections, and the expression of @entity71139 was investigated through the immunohistochemistry method. The average diameter of SF had the smallest value in the anagen stage, and significant difference (P   <   0.05) was found between the anagen stage and other stages. The density of SF increased gradually through the different growing stages, and significant difference was found between the anagen and procatagen stages (P   <   0.05). With an increase in time (months), the percentage of SF activity increased, and significant difference in the percentage of SF activity was found between the telogen and anagen stages (P   <   0.05). At the telogen stage, the layers of @entity20861 ( @entity20861 ) of SF were unclear, hemidesmosomes between the outer root sheath (ORS) and basement membrane disappeared, and dead cells were found at the top of the SF. The rudiments of new SF were found in the proanagen stage, @entity20861 was thickened, and the cells of ORS were stretched out like fingers. At the anagen stage, the structure of SF was integral, and the @entity389 ( @entity389 ) consisted of three concentric layers (Helen, Huxley, and @entity655 ). The cells of Huxley's layer degenerated gradually, and pseudopodia were formed on the cells of ORS in the procatagen stage. At the catagen stage, the ORS was separated from the @entity389 , and @entity389 disappeared. Huxley's layer was absent in the inactive SF while, the ORS was present in the active SF. @entity71139 was expressed in the epidermis and sebaceous gland o, ORS, @entity389 , hair shaft of SF in the skin. @entity71139 was expressed weakly during procatagen, catagen, and telogen stage, while with an increase in proanagen and anagen stage, significant difference was found between them. These findings demonstrated the ultra-structural features of SF could provide the useful activity criteria, and @entity71139 associated with the SF activity.

title: Determination of Secondary Follicle Characteristics, Density, Activity, and XXXX Expression Pattern of Hexi Cashmere @entity1237 Breed.

entities_list: @entity20861 :: ('MESH:D018204', 'Disease') :: ['CTS', 'connective tissue sheath']

entities_list: @entity389 :: ('MESH:D007759', 'Disease') :: ['IRS', 'inner root sheath']

entities_list: @entity655 :: ('MESH:C535504', 'Disease') :: ['Cuticle layers']

answer: @entity71139 :: (102178245,Gene) :: ['Hoxc13']


abstract: This experiment was conducted to identify some aspects of secondary follicle (SF) characteristics of Hexi cashmere @entity1237 at five different growing stages in one year in order and discover the expression pattern of @entity71139 in a SF cycling to provide morphological basis for studying the growth of cashmere. Ten cashmere @entity1237 of one-year old (5 males, 5 females) were included in this study. The density and activity of SF were observed and measured by making paraffin sections, the ultra-structural features of SF were studied under transmission electron microscopy (TEM) by making ultra-thin sections, and the expression of @entity71139 was investigated through the immunohistochemistry method. The average diameter of SF had the smallest value in the anagen stage, and significant difference (P   <   0.05) was found between the anagen stage and other stages. The density of SF increased gradually through the different growing stages, and significant difference was found between the anagen and procatagen stages (P   <   0.05). With an increase in time (months), the percentage of SF activity increased, and significant difference in the percentage of SF activity was found between the telogen and anagen stages (P   <   0.05). At the telogen stage, the layers of @entity20861 ( @entity20861 ) of SF were unclear, hemidesmosomes between the outer root sheath (ORS) and basement membrane disappeared, and dead cells were found at the top of the SF. The rudiments of new SF were found in the proanagen stage, @entity20861 was thickened, and the cells of ORS were stretched out like fingers. At the anagen stage, the structure of SF was integral, and the @entity389 ( @entity389 ) consisted of three concentric layers (Helen, Huxley, and @entity655 ). The cells of Huxley's layer degenerated gradually, and pseudopodia were formed on the cells of ORS in the procatagen stage. At the catagen stage, the ORS was separated from the @entity389 , and @entity389 disappeared. Huxley's layer was absent in the inactive SF while, the ORS was present in the active SF. @entity71139 was expressed in the epidermis and sebaceous gland o, ORS, @entity389 , hair shaft of SF in the skin. @entity71139 was expressed weakly during procatagen, catagen, and telogen stage, while with an increase in proanagen and anagen stage, significant difference was found between them. These findings demonstrated the ultra-structural features of SF could provide the useful activity criteria, and @entity71139 associated with the SF activity.

title: Determination of Secondary Follicle Characteristics, Density, Activity, and @entity71139 Expression Pattern of Hexi Cashmere XXXX Breed.

answer: @entity1237 :: (9925,Species) :: ['Goats']


abstract: Between 1979 and 1985, 552 Ionescu-Shiley valves were implanted in 511 @entity1 . The Hancock valve was implanted in 122 @entity1 (129 valves) between 1982 and 1983. Sixty percent of procedures were isolated aortic valve replacements. In the Ionescu series, 59% of these were 19 or 21 mm valves while only 15% of the Hancock valves were of this size. For isolated mitral valve replacement, 76% of Ionescu-Shiley valves were 25 to 27 mm, compared to 36% of the Hancock valves. @entity1 age, sex, prior operations, concomitant surgery (usually coronary bypass), operative mortality and late deaths were similar for both valves. A mean follow-up of 38 months was obtained for each valve population (99% complete) representing a cumulative 1497 @entity1 -years for the Ionescu-Shiley valve and 375.4 @entity1 -years for the Hancock valve. Actuarial survival for the former was 73 +/- 4% at 72 months, and 65 +/- 14% for Hancock valves at 60 months. The frequency of major events during follow-up ( @entity1031 , anticoagulant related @entity548 , bland @entity2478 and @entity340 ) were similar, but the frequency of primary tissue valve failure was markedly different for the two valves (1.1% per @entity1 -year for Ionescu-Shiley valves and 5.9% for the Hancock valve). The mean interval to replacement of an Ionescu mitral prosthesis was significantly shorter (23.4 months) than for replacement of an aortic prosthesis (42 months) while the mean interval to replacement of an Ionescu aortic and/or a Hancock aortic or mitral were all similar.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Clinical results of pericardial xenograft valves: the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity2478 :: ('MESH:D019559', 'Disease') :: ['perivalvular leak']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolism']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['prosthetic valve endocarditis']

answer: @entity340 :: (MESH:D006349,Disease) :: ['Ionescu-Shiley and Hancock valves']