abstract: We present two cases of concurrent development of @entity4407 ( @entity4407 ) with @entity1072 ( @entity1072 ) and one related to clonal B-cell @entity6113 ( @entity5315 ). Both @entity1 were referred for @entity6113 and @entity1148 . A bone marrow biopsy revealed infiltration of small, mature lymphocytes and @entity1373 . Flow cytometric immunophenotyping and immunoglobulin (IG) gene clonality tests revealed clonal B lymphocytes. Both @entity1 were positive for the @entity4016 @entity4017 mutation in whole bone marrow aspirate. The @entity4016 @entity4017 mutation was present in isolated B lymphocytes of @entity1 1, but not @entity1 2. Cytogenetics were normal in both @entity1 . An array comparative genomic hybridization (CGH) analyses of B cells revealed a gain of 4q28.3, which is reported in @entity1893 , in @entity1 1, and deletion 22q11.22, which is associated with @entity1072 , and a gain of Xp22.31 in @entity1 2. In both @entity1 , B cells showed no @entity5 ( @entity5 )-specific @entity74 . These results suggest that different oncogenic mechanisms in each cell lineage may underlie the concurrent development of @entity4407 and @entity1072 (or @entity5315 ). Array CGH may be helpful in identifying the pathogenic mechanism in cases of concurrent development of @entity706 and @entity5 .

title: Two cases of concurrent development of XXXX with @entity1072 , one related to clonal B-cell @entity6113 , tested by array comparative genomic hybridization.

answer: @entity4407 :: (MESH:D013920,Disease) :: ['essential thrombocythemia']


abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity5 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity519 PET tracers frequently used in the clinic, @entity9241 , @entity15437 , and @entity26641 , in a preclinical @entity5 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity5 ( @entity5 ), spatial reproducibility, and sensitivity to @entity26 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity980 R1-bearing WAG/Rij @entity35 were acquired at multiple time points post injection (p.i.) with one of the @entity519 tracers. @entity5 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity26 modifications were induced by exposure to either @entity15436 / @entity4571 treatment or 7% @entity26 breathing. RESULTS: @entity5 was stabilized and maximal at 2 hours p.i. for @entity15437 (4.0    0.5) and at 3 hours p.i. for @entity26641 (7.2    0.7), whereas @entity9241 showed a constant increasing @entity5 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity9241 (R = 0.86; Dice coefficient = 0.76) and @entity26641 (R = 0.76; Dice coefficient = 0.70), whereas @entity15437 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity519 fraction resulted in enhanced mean standardized uptake values for both @entity26641 and @entity15437 upon 7% @entity26 breathing. Only @entity9241 uptake was found to be reversible upon exposure to @entity4571 and @entity15436 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the XXXX PET Tracers @entity26641 , @entity15437 , and @entity9241 in a Preclinical Tumor Model.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor hypoxia', 'tumor', 'tumor-to-blood ratios', 'TBR']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia', 'hypoxic']

entities_list: @entity980 :: ('MESH:D012208', 'Disease') :: ['rhabdomyosarcoma']

entities_list: @entity4571 :: ('MESH:D009536', 'Chemical') :: ['nicotinamide']

answer: @entity519 :: (MESH:D000860,Disease) :: ['Hypoxia']


abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity5 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity519 PET tracers frequently used in the clinic, @entity9241 , @entity15437 , and @entity26641 , in a preclinical @entity5 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity5 ( @entity5 ), spatial reproducibility, and sensitivity to @entity26 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity980 R1-bearing WAG/Rij @entity35 were acquired at multiple time points post injection (p.i.) with one of the @entity519 tracers. @entity5 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity26 modifications were induced by exposure to either @entity15436 / @entity4571 treatment or 7% @entity26 breathing. RESULTS: @entity5 was stabilized and maximal at 2 hours p.i. for @entity15437 (4.0    0.5) and at 3 hours p.i. for @entity26641 (7.2    0.7), whereas @entity9241 showed a constant increasing @entity5 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity9241 (R = 0.86; Dice coefficient = 0.76) and @entity26641 (R = 0.76; Dice coefficient = 0.70), whereas @entity15437 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity519 fraction resulted in enhanced mean standardized uptake values for both @entity26641 and @entity15437 upon 7% @entity26 breathing. Only @entity9241 uptake was found to be reversible upon exposure to @entity4571 and @entity15436 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the @entity519 PET Tracers XXXX , @entity15437 , and @entity9241 in a Preclinical Tumor Model.

answer: @entity26641 :: (MESH:C553729,Chemical) :: ['[(18)F]HX4']


abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity5 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity519 PET tracers frequently used in the clinic, @entity9241 , @entity15437 , and @entity26641 , in a preclinical @entity5 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity5 ( @entity5 ), spatial reproducibility, and sensitivity to @entity26 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity980 R1-bearing WAG/Rij @entity35 were acquired at multiple time points post injection (p.i.) with one of the @entity519 tracers. @entity5 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity26 modifications were induced by exposure to either @entity15436 / @entity4571 treatment or 7% @entity26 breathing. RESULTS: @entity5 was stabilized and maximal at 2 hours p.i. for @entity15437 (4.0    0.5) and at 3 hours p.i. for @entity26641 (7.2    0.7), whereas @entity9241 showed a constant increasing @entity5 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity9241 (R = 0.86; Dice coefficient = 0.76) and @entity26641 (R = 0.76; Dice coefficient = 0.70), whereas @entity15437 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity519 fraction resulted in enhanced mean standardized uptake values for both @entity26641 and @entity15437 upon 7% @entity26 breathing. Only @entity9241 uptake was found to be reversible upon exposure to @entity4571 and @entity15436 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the @entity519 PET Tracers @entity26641 , @entity15437 , and XXXX in a Preclinical Tumor Model.

answer: @entity9241 :: (MESH:C031843,Chemical) :: ['[(18)F]FMISO']


abstract: PURPOSE: Several individual clinical and preclinical studies have shown the possibility of evaluating @entity5 by using noninvasive positron emission tomography (PET). The current study compared 3 @entity519 PET tracers frequently used in the clinic, @entity9241 , @entity15437 , and @entity26641 , in a preclinical @entity5 model. Tracer uptake was evaluated for the optimal time point for imaging, @entity5 ( @entity5 ), spatial reproducibility, and sensitivity to @entity26 modification. METHODS AND MATERIALS: PET/computed tomography (CT) images of @entity980 R1-bearing WAG/Rij @entity35 were acquired at multiple time points post injection (p.i.) with one of the @entity519 tracers. @entity5 values were calculated, and reproducibility was investigated by voxel-to-voxel analysis, represented as correlation coefficients (R) or Dice similarity coefficient of the high-uptake volume. Tumor @entity26 modifications were induced by exposure to either @entity15436 / @entity4571 treatment or 7% @entity26 breathing. RESULTS: @entity5 was stabilized and maximal at 2 hours p.i. for @entity15437 (4.0    0.5) and at 3 hours p.i. for @entity26641 (7.2    0.7), whereas @entity9241 showed a constant increasing @entity5 (9.0    0.8 at 6 hours p.i.). High spatial reproducibility was observed by voxel-to-voxel comparisons and Dice similarity coefficient calculations on the 30% highest uptake volume for both @entity9241 (R = 0.86; Dice coefficient = 0.76) and @entity26641 (R = 0.76; Dice coefficient = 0.70), whereas @entity15437 was less reproducible (R = 0.52; Dice coefficient = 0.49). Modifying the @entity519 fraction resulted in enhanced mean standardized uptake values for both @entity26641 and @entity15437 upon 7% @entity26 breathing. Only @entity9241 uptake was found to be reversible upon exposure to @entity4571 and @entity15436 . CONCLUSIONS: This study indicates that each tracer has its own strengths and, depending on the question to be answered, a different tracer can be put forward.

title: A Comparative Study of the @entity519 PET Tracers @entity26641 , XXXX , and @entity9241 in a Preclinical Tumor Model.

answer: @entity15437 :: (MESH:C498052|MESH:C549903,Chemical) :: ['[(18)F]FAZA']


abstract: BACKGROUND: The choroid plexuses (CPs) are brain structures located in the brain ventricles, involved in the production and reabsorption of cerebrospinal fluid (CSF) components, cerebral immune surveillance, and various endocrine-enzymatic activities and acts as a  CSF-blood barrier. This study investigated to determine if there is a  link between @entity63 and meningo-cerebral inflammation processes. MATERIAL AND METHODS: This study was conducted on 18 @entity95 . Four @entity95 were used as the baseline group to examine the normal structures. Fourteen of the @entity95 were used as the study group by injecting 1.00cc of homologous blood into their cisterna magna. The animals were followed by daily monitoring for ten days and then slaughtered. Apoptotic degeneration of the @entity2723 cells was determined and statistical analyses were carried out using normal and apoptotic @entity2723 cell numbers. Data analyses were comprised of Mann-Whitney U  tests. Differences were considered to be significant if p  <  0.005. RESULTS: Five animals belonging to the study group died between the 5th and 8th days. Unconsciousness, neck stiffness, @entity410 , @entity221 , @entity386 , @entity943 , and breathing disturbances were observed in all of the animals who subsequently died. Intraventricular blood leakage was detected in all the dead and three surviving animals. @entity2553 , @entity3193 , @entity66 , pia-arachnoid thickening, @entity1104 and blood cell density in the subarachnoid spaces were more severe in the more @entity528 animals than those of the others. There were significant differences between the apoptotic @entity2723 cell density and blood cell density in the subarachnoid spaces (p  <  0.005). CONCLUSIONS: @entity510 ( @entity510 ) extending to brain ventricles causes @entity63 by way of triggered @entity455 . It should be emphasized that the prevention of @entity2723 function may be an important part of the protection of the brain in @entity510 .

title: Parallel development of choroid plexus degeneration and meningeal inflammation in XXXX - experimental study.

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsion']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['choroidal artery vasospasm']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['choroidal cell apoptosis']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic CP injury', 'ischemic degeneration of the CP']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['SAH', 'Subarachnoid hemorrhage']

entities_list: @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal ependymal cell injury']

entities_list: @entity1104 :: ('MESH:D000267', 'Disease') :: ['meningocortical adhesions']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['Choroidal artery spasm']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['CP degenerated']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['cardiac arrhythmia']

answer: @entity510 :: (MESH:D013345,Disease) :: ['subarachnoid hemorrhage']


abstract: Dynamic testing includes procedures that examine the effects of brief training on test performance where pre- to post-training change reflects @entity1 ' learning potential. The objective of this systematic review was to provide clinicians and researchers insight into the concept and methodology of dynamic testing and to explore its predictive validity in adult @entity1 with @entity73 . The following electronic databases were searched: PubMed, PsychINFO, and Embase/Medline. Of 1141 potentially relevant articles, 24 studies met the inclusion criteria. The mean methodological quality score was 4.6 of 8. Eleven different dynamic tests were used. The majority of studies used dynamic versions of the Wisconsin Card Sorting Test. The training mostly consisted of a combination of performance feedback, reinforcement, expanded instruction, or strategy training. Learning potential was quantified using numerical (post-test score, difference score, gain score, regression residuals) and categorical (groups) indices. In five of six longitudinal studies, learning potential significantly predicted rehabilitation outcome. Three of four studies supported the added value of dynamic testing over conventional testing in predicting rehabilitation outcome. This review provides preliminary support that dynamic tests can provide a valuable addition to conventional tests to assess @entity1 ' abilities. Although promising, there was a large variability in methods used for dynamic testing and, therefore, it remains unclear which dynamic testing methods are most appropriate for @entity1 with @entity73 . More research is warranted to further evaluate and refine dynamic testing methodology and to further elucidate its predictive validity concerning rehabilitation outcomes relative to other cognitive and functional status indices.

title: Dynamic testing of learning potential in adults with XXXX : A systematic review of methodology and predictive value.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairments']

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive impairments']


abstract: BACKGROUND: @entity6313 has several clinical presentations and is caused by various infectious organisms. OBJECTIVE: To provide guidance for selection of appropriate treatment. METHODS: The literature on @entity6313 management was reviewed to generate an evidence-based decision tree. RESULTS AND CONCLUSION: Several options are available: @entity8974 , @entity2059 , @entity2380 , @entity29444 8% nail lacquer, @entity36018 10% nail solution, and laser therapy. Further studies on lasers are needed before use can be recommended. Nondermatophyte molds or @entity325 can be managed with @entity8974 or @entity2059 with or without topicals. @entity2059 , @entity2380 , and @entity36018 can be used for @entity6923 . For dermatophytes, topicals can be considered for mild to moderate @entity6313 . For moderate to severe cases, any oral monotherapy can be used; however, we suggest @entity8974 if there is a possibility of a drug interaction. These recommendations can be applied for all ages, immune function, or metabolic status, but proper monitoring and contraindications should be taken into consideration.

title: Management of XXXX in Canada in 2014.

entities_list: @entity8974 :: ('MESH:C041359', 'Chemical') :: ['terbinafine']

entities_list: @entity6923 :: ('MESH:C536777', 'Disease') :: ['Candida infection']

entities_list: @entity2380 :: ('MESH:D015725', 'Chemical') :: ['fluconazole']

entities_list: @entity36018 :: ('MESH:C431707', 'Chemical') :: ['efinaconazole']

entities_list: @entity6313 :: ('MESH:D014009', 'Disease') :: ['Onychomycosis', 'onychomycosis']

entities_list: @entity29444 :: ('MESH:C011585', 'Chemical') :: ['ciclopirox']

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['mixed infection']

entities_list: @entity2059 :: ('MESH:D017964', 'Chemical') :: ['Itraconazole', 'itraconazole']

answer: @entity6313 :: (MESH:D014009,Disease) :: ['onychomycosis']


abstract: @entity16 can occur in the postoperative period of @entity1498 repair, @entity63 being the pathogenic factor most likely to be involved. This study was designed to evaluate the extent of the hemodynamic changes proximal and distal to the @entity1498 at the time of cross-clamping, as well as the effects of @entity30049 and @entity3044 upon the hemodynamic changes. Included in the study were 17 @entity1 with adult type coarctations who had dual hemodynamic monitoring. During cross-clamping, there was an increase in the gradient between proximal and distal pressures, with severe @entity551 (< 50 mm Hg) occurring in six @entity1 . @entity3044 corrected the @entity551 in five @entity1 , but the sixth required a surgical shunt. @entity30049 was effective for the treatment of proximal @entity101 ; however, it also decreased distal pressure. The ligation of collateral vessels was associated with a decrease in distal pressures as well. During cross-clamping, pentolinium was useful for the management of proximal @entity101 and @entity3044 increased the distal pressures in some of the @entity1 who presented @entity551 . However, because of the difficulties in predicting the individual response, their administration would be best guided by dual pressure monitoring. It is postulated that the recognition and proper treatment of @entity551 may be an important factor in the prophylaxis of @entity260 .

title: Technical and pharmacologic management of @entity551 during repair of XXXX .

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Neurologic and abdominal complications']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['Isoproterenol', 'isoproterenol']

entities_list: @entity1498 :: ('MESH:D001017', 'Disease') :: ['aortic coarctation', 'coarctation']

entities_list: @entity30049 :: ('MESH:D010425', 'Chemical') :: ['pentolinium', 'Pentolinium']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension', 'distal hypotension']

answer: @entity1498 :: (MESH:D001017,Disease) :: ['coarctation of the aorta']


abstract: @entity16 can occur in the postoperative period of @entity1498 repair, @entity63 being the pathogenic factor most likely to be involved. This study was designed to evaluate the extent of the hemodynamic changes proximal and distal to the @entity1498 at the time of cross-clamping, as well as the effects of @entity30049 and @entity3044 upon the hemodynamic changes. Included in the study were 17 @entity1 with adult type coarctations who had dual hemodynamic monitoring. During cross-clamping, there was an increase in the gradient between proximal and distal pressures, with severe @entity551 (< 50 mm Hg) occurring in six @entity1 . @entity3044 corrected the @entity551 in five @entity1 , but the sixth required a surgical shunt. @entity30049 was effective for the treatment of proximal @entity101 ; however, it also decreased distal pressure. The ligation of collateral vessels was associated with a decrease in distal pressures as well. During cross-clamping, pentolinium was useful for the management of proximal @entity101 and @entity3044 increased the distal pressures in some of the @entity1 who presented @entity551 . However, because of the difficulties in predicting the individual response, their administration would be best guided by dual pressure monitoring. It is postulated that the recognition and proper treatment of @entity551 may be an important factor in the prophylaxis of @entity260 .

title: Technical and pharmacologic management of XXXX during repair of @entity1498 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity551 :: (MESH:D007022,Disease) :: ['distal hypotension']


abstract: Changes of bone during pregnancy and during lactation evaluated by @entity79 ( @entity79 ) may have implications for risk of @entity170 and @entity174 . We studied @entity79 in @entity1 of differing ages, parity, and lactation histories immediately postpartum for @entity79 , T-scores, and Z-scores. Institutional Review Board approval was received. All @entity1 while still in hospital postpartum were asked to participate. @entity79 was performed by dual-energy X-ray absorptiometry (DXA) machine at femoral neck (FN) and @entity3570 ( @entity3570 ) by a single technician. Of 132 @entity1 , 73 (55.3%) were  <=30 years; 27 (20.5%) were primiparous; 36 (27.3%) were grand multiparous; 35 (26.5%) never breast fed. Mean FN T-scores and Z-scores were higher than respective mean @entity3570 scores, but all means were within the normal limits. Mean @entity3570 T-scores and Z-scores were highest in the grand multiparas. There were only 2 (1.5%) outliers with low Z-scores. We conclude that, in a large cohort of Israeli @entity1 with @entity79 parameters assessed by DXA within two days postpartum, mean T-scores and Z-scores at both the @entity3570 and FN were within normal limits regardless of age (20-46 years), parity (1-13 viable births), and history of either no or prolonged months of lactation (up to 11.25 years).

title: Bone mineral density in gravida: effect of pregnancies and breast-feeding in XXXX of differing ages and parity.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity3570 :: ('MESH:D016135', 'Disease') :: ['lumbar spine', 'LS']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: @entity717 Society-sponsored Unified @entity191 Rating Scale (MDS-UPDRS) has separate items for measuring @entity25 (item 1.7) and @entity25 (1.8). The aim of our study was to evaluate the screening sensitivity and specificity of these items to the @entity1726 Sleep Scale 2nd version (PDSS-2) and Epworth Sleepiness Scale (ESS). In this nationwide, cross-sectional study 460 @entity1726 @entity1 were enrolled. Spearman's rank correlation coefficients were calculated between the individual items, domains, and the total score of PDSS-2 and item 1.7 of MDS-UPDRS. Similarly, the items and the total score of ESS were contrasted to item 1.8 of MDS-UPDRS. After developing generalized ordinal logistic regression models, the transformed and observed scores were compared by Lin's Concordance Correlation Coefficient. Only item 3 difficulties staying asleep and the "disturbed sleep" domain of PDSS-2 showed high correlation with " @entity25 " item 1.7 of the MDS-UPDRS. Total score of PDSS-2 had moderate correlation with this MDS-UPRDS item. The total score of ESS showed the strongest, but still moderate, correlation with " @entity25 " item 1.8 of MDS-UPDRS. As intended, the MDS-UPDRS serves as an effective screening tool for both @entity25 and @entity25 and identifies subjects whose disabilities need further investigation.

title: Is the MDS-UPDRS a Good Screening Tool for Detecting Sleep Problems and Daytime Sleepiness in XXXX ?

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's Disease"]

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Movement Disorder']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['daytime sleepiness', 'sleep problems']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's Disease']


abstract: Recent research has confirmed that between 25% and 33% of all hospitalized @entity1 experience unacceptable levels of @entity158 . Studies further indicate that this reduces @entity1 satisfaction levels, lengthens hospital stays, and increases cost. Hospitals are aiming to discharge @entity1 earlier, and this can interfere with adequate @entity158 management. Therefore, the @entity158 service at Chelsea and Westminster Hospital has adapted to this changing model of care. An increasing body of evidence demonstrates that psychological factors are key components of @entity1 ' @entity158 experiences in both acute and @entity1118 . Therefore, it is reasonable to suggest a clinical psychologist should be involved in @entity158 management. This small study discusses three cases that highlight how @entity1 care could be improved by including a clinical psychologist as part of the @entity158 team. Two cases particularly highlight the active role of the psychologist in the diagnosis and management of common conditions such as fear and @entity148 , along with other @entity146 comorbidities. The management therefore employed an eclectic approach adapted from @entity1118 and comprising of behavioral, cognitive behavioral, and dialectical behavioral therapeutic techniques blended with brief counseling. The third case exemplifies the importance of nurse- @entity1 interactions and the quality of nurse- @entity1 relationships on @entity1 outcomes. Here, the psychologist helped to optimize communication and to resolve a difficult and potentially risk-laden situation. This small case series discusses the benefits derived from the involvement of a clinical psychologist in the management of @entity158 , and therefore illustrates the need for novel initiatives for @entity158 services. However, future research is warranted to validate this approach.

title: The clinical psychologist and the management of XXXX : a small case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'inpatient pain']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity158 :: (MESH:D010146,Disease) :: ['inpatient pain']


abstract: The cognitive model of reading comprehension (RC) posits that RC is a result of the interaction between decoding and linguistic comprehension. Recently, the notion of decoding skill was expanded to include word recognition. In addition, some studies suggest that other skills could be integrated into this model, like processing speed, and have consistently indicated that this skill influences and is an important predictor of the main components of the model, such as vocabulary for comprehension and phonological awareness of word recognition. The following study evaluated the components of the RC model and predictive skills in @entity1 and adolescents with @entity5545 . 40 @entity1 and adolescents (8-13 years) were divided in a Dyslexic Group (DG; 18 @entity1 , MA = 10.78, SD = 1.66) and control group (CG 22 @entity1 , MA = 10.59, SD = 1.86). All were students from the 2nd to 8th grade of elementary school and groups were equivalent in school grade, age, gender, and IQ. Oral and RC, word recognition, processing speed, picture naming, receptive vocabulary, and phonological awareness were assessed. There were no group differences regarding the accuracy in oral and RC, phonological awareness, naming, and vocabulary scores. DG performed worse than the CG in word recognition (general score and orthographic confusion items) and were slower in naming. Results corroborated the literature regarding word recognition and processing speed deficits in @entity5545 . However, dyslexics can achieve normal scores on RC test. Data supports the importance of delimitation of different reading strategies embedded in the word recognition component. The role of processing speed in reading problems remain unclear.

title: Reading component skills in XXXX : word recognition, comprehension and processing speed.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

answer: @entity5545 :: (MESH:D004410,Disease) :: ['dyslexia']


abstract: In @entity1691 ( @entity1691 ), thoracic range of motion is often greatly limited. The objective of the study was to describe the effects of 12 weeks of Glossopharyngeal Insufflation (GI) training in @entity1 with @entity1691 . Dynamic spirometry included vital capacity, forced expiratory volume, and peak expiratory flow. @entity1514 and lumbar range of motion was assessed by tragus-to-wall distance, modified Schober test, and tape measure. Disease activity, activity limitation, and health perception were assessed using the BAS-Indices, and @entity2701 in the thoracic region during GI was assessed using the Borg CR-10 scale. Adherence to training was recorded in an activity log, along with any remarks on the training. Ten @entity1 were recruited and six male @entity1 fulfilled the study protocol. Three @entity1 were able to learn GI by exceeding their maximal vital capacity with 5% using GI. A significant increase in thoracic range of motion both on costae IV (P = 0.04) and at the level of the xiphoid process (P = 0.04) was seen. Thus, @entity1 with @entity1691 can practice GI, it is safe if maximal exertion is avoided, and @entity1 with some mobility in the chest can increase their lung function substantially by performing GI during 12 weeks.

title: Effects of glossopharyngeal insufflation in XXXX : a pilot study.

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['AS', 'Ankylosing Spondylitis']

answer: @entity1691 :: (MESH:D013167,Disease) :: ['ankylosing spondylitis']


abstract: OBJECTIVES: @entity1 with @entity309 ( @entity309 ) have a high risk of @entity65 ( @entity65 ). Recent national and international guidelines suggest strict treatment of @entity65 risk factors in @entity309 . The aim of this study was to evaluate the self-reported adherence to CV prevention strategies in @entity1 with @entity309 . METHOD: @entity309 @entity1 visiting an outpatient clinic for strict @entity65 risk management received a validated questionnaire to evaluate adherence to CV prevention strategies. Strict treatment targets were defined and lifestyle recommendations were given following a prespecified protocol. @entity65 risk was assessed using the SCORE algorithm. RESULTS: In total, 111 questionnaires were returned (response rate of 82%). A high 10-year @entity65 risk (>=  20%) was present in 53%, but only 3% thought they had an increased @entity65 risk. A total of 53% of @entity1 reported that they 'follow the doctors' suggestions exactly' and 75% reported finding it 'easy to follow the suggestions'. Of the 69% of @entity1 who were prescribed lipid- and/or blood pressure-lowering drugs, 90% reported taking all prescribed tablets. The advice to follow a diet was given to 42%, of whom 68% said they followed the advised diet. Physical exercise was advised to 67%, of whom 62% said they performed specific physical exercise on at least 3 days a week. The adherence to lifestyle recommendations was not significantly different across the @entity65 risk groups. CONCLUSIONS: @entity309 @entity1 tend to underestimate their @entity65 risk. The self-reported adherence of @entity309 @entity1 to @entity65 risk management was high concerning pharmaceutical interventions and moderate in the case of lifestyle interventions.

title: Adherence to cardiovascular prevention strategies in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: OBJECTIVES: @entity1 with @entity309 ( @entity309 ) have a high risk of @entity65 ( @entity65 ). Recent national and international guidelines suggest strict treatment of @entity65 risk factors in @entity309 . The aim of this study was to evaluate the self-reported adherence to CV prevention strategies in @entity1 with @entity309 . METHOD: @entity309 @entity1 visiting an outpatient clinic for strict @entity65 risk management received a validated questionnaire to evaluate adherence to CV prevention strategies. Strict treatment targets were defined and lifestyle recommendations were given following a prespecified protocol. @entity65 risk was assessed using the SCORE algorithm. RESULTS: In total, 111 questionnaires were returned (response rate of 82%). A high 10-year @entity65 risk (>=  20%) was present in 53%, but only 3% thought they had an increased @entity65 risk. A total of 53% of @entity1 reported that they 'follow the doctors' suggestions exactly' and 75% reported finding it 'easy to follow the suggestions'. Of the 69% of @entity1 who were prescribed lipid- and/or blood pressure-lowering drugs, 90% reported taking all prescribed tablets. The advice to follow a diet was given to 42%, of whom 68% said they followed the advised diet. Physical exercise was advised to 67%, of whom 62% said they performed specific physical exercise on at least 3 days a week. The adherence to lifestyle recommendations was not significantly different across the @entity65 risk groups. CONCLUSIONS: @entity309 @entity1 tend to underestimate their @entity65 risk. The self-reported adherence of @entity309 @entity1 to @entity65 risk management was high concerning pharmaceutical interventions and moderate in the case of lifestyle interventions.

title: Adherence to cardiovascular prevention strategies in XXXX with @entity309 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Background. Only some studies provide sufficient data regarding the effects of nonpostbariatric (aesthetic) abdominoplasty on various aspects of quality of life. Nevertheless, when considering the effects on eating habits, publications are lacking. Therefore we decided to assess the effects of nonpostbariatric abdominoplasty on @entity1277 symptoms, @entity458 , and quality of life. Materials and Methods. 64 consecutive @entity1 underwent nonpostbariatric abdominoplasty. Three outcome measures were completed: the @entity1277 Inventory (EDI), Raitasalo's modification of the Beck Depression Inventory (RBDI), and the 15D general quality of life questionnaire. Results. The mean age at baseline was 42 years and the mean body mass index (BMI) 26.4. Fifty-three (83%) @entity1 completed all the outcome measures with a mean follow-up time of 5 months. A significant improvement from baseline to follow-up was noted in @entity1 's overall quality of life, body satisfaction, effectiveness, sexual functioning, and self-esteem. The @entity1 were significantly less @entity308 and had significantly less drive for thinness as well as @entity6426 , and their overall risk of developing an @entity1277 also decreased significantly. Conclusions. Abdominoplasty results in significantly improved quality of life, body satisfaction, effectiveness, sexual functioning, self-esteem, and mental health. The risk of developing an @entity1277 is decreased significantly. This trial is registered with Clinicaltrials.gov NCT02151799.

title: Abdominoplasty improves quality of life, @entity458 , and XXXX symptoms: a prospective study.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity1277 :: ('MESH:D001068', 'Disease') :: ['Eating Disorder', 'eating disorder']

answer: @entity1277 :: (MESH:D001068,Disease) :: ['eating disorder']


abstract: Background. Only some studies provide sufficient data regarding the effects of nonpostbariatric (aesthetic) abdominoplasty on various aspects of quality of life. Nevertheless, when considering the effects on eating habits, publications are lacking. Therefore we decided to assess the effects of nonpostbariatric abdominoplasty on @entity1277 symptoms, @entity458 , and quality of life. Materials and Methods. 64 consecutive @entity1 underwent nonpostbariatric abdominoplasty. Three outcome measures were completed: the @entity1277 Inventory (EDI), Raitasalo's modification of the Beck Depression Inventory (RBDI), and the 15D general quality of life questionnaire. Results. The mean age at baseline was 42 years and the mean body mass index (BMI) 26.4. Fifty-three (83%) @entity1 completed all the outcome measures with a mean follow-up time of 5 months. A significant improvement from baseline to follow-up was noted in @entity1 's overall quality of life, body satisfaction, effectiveness, sexual functioning, and self-esteem. The @entity1 were significantly less @entity308 and had significantly less drive for thinness as well as @entity6426 , and their overall risk of developing an @entity1277 also decreased significantly. Conclusions. Abdominoplasty results in significantly improved quality of life, body satisfaction, effectiveness, sexual functioning, self-esteem, and mental health. The risk of developing an @entity1277 is decreased significantly. This trial is registered with Clinicaltrials.gov NCT02151799.

title: Abdominoplasty improves quality of life, XXXX , and @entity1277 symptoms: a prospective study.

answer: @entity458 :: (MESH:D020018,Disease) :: ['psychological distress']


abstract: UNASSIGNED: The two main manifestations of @entity378 that require surgery are @entity1276 associated with @entity1906 (TBMH) and @entity75 . TBMH most often responds to medical therapy but surgery is required promptly for those who fail medical therapy. Both ventriculoperitoneal (VP) shunt and endoscopic third ventriculostomy (ETV) are valid options although the latter is more often successful in @entity1 with chronic @entity1276 than in those with acute @entity693 . @entity1 with TBMH are more prone to complications following VP shunt than other @entity1 . The outcome of these @entity1 is determined by the Vellore grade (I to IV) of the @entity1 prior to surgery with those in good grades (I and II) having a better outcome and those in the worst grade (IV) having a high mortality in excess of 80  %. @entity1 with @entity75 present clinically with features of a @entity75 , indistinguishable clinically from other pathologies. CT and MR features might provide a probable diagnosis of a @entity6551 but most often a histological diagnosis is desirable. Empiric medical therapy is reserved for a small number of @entity1 . Although the treatment of @entity75 is essentially medical, surgery is required when the diagnosis is in doubt, to reduce raised intracranial pressure or local mass effect and to obtain tissue for culture and sensitivity studies. Stereotactic biopsy, stereotactic craniotomy and excision of superficial small @entity6551 and microsurgery are all procedures used to manage @entity75 . The outcome in @entity1 with @entity75 is good if the tuberculous bacillus is sensitive to the anti-tuberculous therapy. The duration of therapy is debated but we suggest at least 18  months of combination therapy with three or four anti-tuberculous drugs and continue the therapy till the @entity6551 has resolved on neuro-imaging.

title: Surgery for XXXX : a review.

entities_list: @entity6551 :: ('MESH:D014375', 'Disease') :: ['tuberculomas', 'tuberculoma']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain mass', 'brain tuberculomas']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis']

entities_list: @entity1906 :: ('MESH:D014390', 'Disease') :: ['tuberculous meningitis']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['brain tuberculosis']

answer: @entity378 :: (MESH:D014376,Disease) :: ['brain tuberculosis']


abstract: Bulgarian statistics of recent years (2008-2012) indicate weak knowledge and use of the various screenings . Low percentage of pregnant passed screening tests and improper interpretation of the calculated risks, has led on the one hand to the high percentage of invasive diagnostics in the surveyed population (6% instead of 3%) to diagnose 90% of pregnancies with trisomy 21, and at the same time low percentage diagnosed pregnancies with @entity1467 in the population of all pregnant @entity1 (tested and untested). We are performing invasive procedures of almost all pregnant @entity1 over 35 years old, and instead of the screening in the 1st trimester, we still use the screening in the 2nd trimester which is with limited application in Europe because of the high rate of false positive (false positive rate) and the unsatisfactory rate of recognized pregnancies with chromosomal defects (detedtion rate 70%). OBJECTIVE: To make the analysis of screening data, in the 1st and 2nd trimester for the period 2008-2012 in the Hospital "Maichin Dom" and our Center for Prenatal Diagnosis (respectively 93956 and 5046 pregnant @entity1 observed), the percentage of invasive diagnostic and percent diagnosed with Down syndr. in the total number of pregnancies, 99002 versus the number born with the disease in the country according to data of the National Statistical Institute. METHODS AND MATERIALS Used was the algorytm of @entity827 London to assess the effectiveness of the various screenings (Prof Nikolaides et al.) more specific for each of them - Detection rate and False positive rate, and statistical meta-analyses of H. Cuckle and D. Wright, for the estimated number of pregnancies with Down syndr.and the expected percentage of invasive diagnostics for locating over 90% of them in a population of 100,000 pregnant @entity1 . RESULTS: 99002 Surveyed pregnancies for the period 2008-2012 are around 25% of the total population (377,040 births), there are 7645 invasive procedures (i.e. 7,7 % of the expected 3%) and are diagnosed with @entity1467 pregnancies were 181 from statistically expected about 200 (i.e., 90%) in the same period, 152 babies are born with TRI 21. CONCLUSIONS: In terms of the lack of a National Strategy for screening for @entity66 , non-compliance with the principles and protocols for consultation of @entity1 about the results obtained and generally poor knowledge of the various screenings have led to the negative attitude of the doctors and @entity1 to screening programs and low percentage of pregnant @entity1 targeted or seeking such tests (about 30%) and a high percentage of invasive diagnosis (due to the high percentage of false positive rate and incorrect interpretation of the calculated risks).

title: [Types of screening for XXXX - results in Bulgaria, conclusions and future objectives].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity1467 :: ('MESH:D004314', 'Disease') :: ["Down's syndrome"]

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['congenital diseases']

answer: @entity66 :: (MESH:D004194,Disease) :: ['congenital diseases']


abstract: INTRODUCTION: Permanent @entity358 ( @entity358 ) remains an essential goal of ablation therapy in @entity1 with @entity955 . Aim of this study was the intra-individual comparison of unexcitability to pacing along the ablation line vs. dormant conduction (DC) as additional procedural endpoints. METHODS: A total of 58 @entity1 with @entity955 ( @entity955 ) underwent @entity358 by circumferential ablation of ipsilateral pulmonary veins (PVs), followed by testing for DC by @entity859 administration. Irrespective of the presence of DC, pacing along the ablation line for left atrium capture was performed and additional radio frequency (RF) energy applied if necessary. PVs with initial DC were re-tested after achieving unexcitability. RESULTS: @entity358 was achieved in 224 of 224 PVs. In 33 of 224 PVs (15%) DC was revealed. At 92 of 112 ablation lines (82%) sites of excitability were found. Three (9%) of the initial 33 PVs with DC showed further DC after achieving unexcitability at repeated testing. 32 of 33 assumed areas of unmasked @entity47627 re-conduction as revealed by DC-testing showed a corresponding site of excitability on the ablation line. After a follow-up of 11.6  3.4 months 79% of @entity1 were free of @entity943 . CONCLUSIONS: Pacing for unexcitability can safely identify potential sites of DC and even sites that would have not been detected by testing for DC. Unexcitability therefore serves as a suitable and safe procedural endpoint not only for @entity1 with contraindications to @entity859 administration. Our data suggest that @entity859 may be expendable when achieving unexcitability along the ablation line. This article is protected by copyright. All rights reserved.

title: Loss of Pace Capture on the Ablation Line During Pulmonary Vein Isolation vs. "Dormant Conduction": Is XXXX Expendable?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['PVI', 'pulmonary vein isolation']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'paroxysmal atrial fibrillation', 'PAF']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity859 :: (MESH:D000241,Chemical) :: ['Adenosine']


abstract: OBJECTIVE: To perform a systematic review and meta-analysis to determine if isolated nasal surgery in @entity1 with @entity27 and nasal airway obstruction @entity27 . DATA SOURCES: Computerized searches were performed in PubMed, EMBASE, and the Cochrane Library through October 2014. Manual searches and subject matter expert input was also solicited. REVIEW METHODS: A search protocol was defined a priori, and 2 independent investigators performed the data extraction, focusing on relevant data, including quality data polysomnography data, and taking note of methodological quality and risk for bias. RESULTS: The 10 studies meeting criteria included a total of 320 @entity1 . There were 2 randomized controlled trials, 7 prospective studies, and 1 retrospective study. There was a significant improvement in the pooled results of both Epworth Sleepiness Scale (ESS; difference 3.53, 95% confidence interval [CI] [0.64, 6.23]) and Respiratory Disturbance Index (RDI; 11.06, 95% CI [5.92, 16.19]) scores with isolated nasal surgery. There was no significant improvement in the @entity27 ( @entity27 ) in the random effects model (4.83, 95% CI [-1.6, 11.62]). CONCLUSIONS: The pooled results showed that isolated nasal surgery for @entity1 with @entity27 improved some sleep parameters, as shown by significant improvements in ESS and RDI, but had no significant improvements on @entity27 . Future controlled studies with larger groups are needed to confirm the benefits of isolated nasal surgery in this @entity1 population.

title: Does Nasal Surgery Improve OSA in XXXX with Nasal Obstruction and OSA? A Meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'nasal obstruction and obstructive sleep apnea', 'improves obstructive sleep apnea', 'Apnea Hypopnea Index', 'AHI']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: Schwann cells (SCs) hold promise for @entity1566 ( @entity1566 ) repair; however, there are limitations for its use as a lone treatment. We showed that acute inhibition of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) by @entity51549 ( @entity15882 ) was neuroprotective and enhanced function following cervical hemicontusion @entity1566 . We hypothesized that combining acute @entity15882 therapy and delayed SC engraftment would further improve neuroprotection and recovery after cervical @entity1566 . Adult female Sprague-Dawley (SD) @entity35 were randomly sorted into 5 groups: sham, vehicle, @entity15882 , SC transplantation, and @entity15882 +SC transplantation. SCs were isolated from adult green fluorescent protein (GFP)-expressing SD @entity35 (GFP-SCs). 200 g/kg @entity15882 (pic) was administered intraperitoneally (IP) twice daily for 7days post- @entity1566 in @entity15882 -treated groups. GFP-SCs (1*10(6) in 5 l medium) were transplanted into the lesion epicenter at the 8th day post- @entity1566 . Forelimb function was tested for 10weeks and histology was assessed. @entity15882 alone significantly reduced lesion (by 40%, p<0.05) and cavitation (by 65%, p<0.05) and improved functional recovery (p<0.05) compared to injury alone. The combination promoted similar neuroprotection (p<0.01 vs. injury); however, GFP-SCs alone did not. Both SC-transplanted groups exhibited remarkable long-term SC survival, SMI-31(+) axon ingrowth and RECA-1(+) vasculature presence in the SC graft; however, @entity15882 +SCs promoted an 89% greater axon-to-lesion ratio than SCs only. We concluded that @entity15882 likely contributed largely to the neuroprotective and functional benefits while SCs facilitated considerable host-tissue interaction and modification. The combination of the two shows promise as an attractive strategy to enhance recovery after @entity1566 .

title: Biphasic XXXX administration and Schwann cell transplantation for repair after cervical contusive @entity1566 .

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI']

entities_list: @entity51549 :: ('MESH:C472777', 'Chemical') :: ['bisperoxovanadium']

answer: @entity51549 :: (MESH:C472777,Chemical) :: ['bisperoxovanadium']


abstract: UNASSIGNED: Schwann cells (SCs) hold promise for @entity1566 ( @entity1566 ) repair; however, there are limitations for its use as a lone treatment. We showed that acute inhibition of the phosphatase and tensin homolog deleted on chromosome ten (PTEN) by @entity51549 ( @entity15882 ) was neuroprotective and enhanced function following cervical hemicontusion @entity1566 . We hypothesized that combining acute @entity15882 therapy and delayed SC engraftment would further improve neuroprotection and recovery after cervical @entity1566 . Adult female Sprague-Dawley (SD) @entity35 were randomly sorted into 5 groups: sham, vehicle, @entity15882 , SC transplantation, and @entity15882 +SC transplantation. SCs were isolated from adult green fluorescent protein (GFP)-expressing SD @entity35 (GFP-SCs). 200 g/kg @entity15882 (pic) was administered intraperitoneally (IP) twice daily for 7days post- @entity1566 in @entity15882 -treated groups. GFP-SCs (1*10(6) in 5 l medium) were transplanted into the lesion epicenter at the 8th day post- @entity1566 . Forelimb function was tested for 10weeks and histology was assessed. @entity15882 alone significantly reduced lesion (by 40%, p<0.05) and cavitation (by 65%, p<0.05) and improved functional recovery (p<0.05) compared to injury alone. The combination promoted similar neuroprotection (p<0.01 vs. injury); however, GFP-SCs alone did not. Both SC-transplanted groups exhibited remarkable long-term SC survival, SMI-31(+) axon ingrowth and RECA-1(+) vasculature presence in the SC graft; however, @entity15882 +SCs promoted an 89% greater axon-to-lesion ratio than SCs only. We concluded that @entity15882 likely contributed largely to the neuroprotective and functional benefits while SCs facilitated considerable host-tissue interaction and modification. The combination of the two shows promise as an attractive strategy to enhance recovery after @entity1566 .

title: Biphasic @entity51549 administration and Schwann cell transplantation for repair after cervical contusive XXXX .

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injury']


abstract: UNASSIGNED: We report an unusual case of @entity12967 wound of the cervical spinal cord, which illustrates the value of post-mortem computed tomography angiography (PMCTA) in cases of @entity1317 . First, we noted a posterior and horizontal trajectory to the neck with complete section of the cervical spinal cord between the first and second cervical vertebrae. This lesion was accompanied by section of the right vertebral and right deep cervical arteries. We also noted an anterior cervical trajectory with an injury to the right internal jugular vein and an anterior right chest wound with a lung trajectory and section of the internal mammary vessels. Cases of @entity1566 secondary to stab wounds are rare in the literature. Only one large series has been published from Cape Town. Complete section of the cervical spinal cord accounts for only 4.5% of all cases. Furthermore, lethal cases are rare and classically victims survive and present neurological sequelae. We found only one similar case but despite the transection of the cervical spinal cord the @entity1 survived. Some studies suggest that PMCTA may be very helpful in @entity1317 . Our observations are consistent with this proposal. The use of different-time acquisitions was essential for detection of the injured vessels.

title: An unusual XXXX wound of the cervical spinal cord: A single case examined by post-mortem computed tomography angiography (PMCTA).

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injury', 'visualizing vascular system injuries']

entities_list: @entity12967 :: ('MESH:D051270', 'Disease') :: ['homicidal stab']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injuries']

answer: @entity12967 :: (MESH:D051270,Disease) :: ['homicidal stab']


abstract: UNASSIGNED: Entanglement in fixed @entity9963 gear is a conservation concern for whales worldwide, including in the United States where @entity204 of North Atlantic right and @entity52287 have exceeded management limits for decades. We examined @entity9963 gear removed from live and dead entangled whales along the US East Coast and the Canadian Maritimes from 1994-2010 to investigate rope polymer type, breaking strength, and diameter in relation to whale species, age, and injury severity. For the 132 retrieved ropes from 70 cases, average tested breaking strength was 2616 lbs (SD 1863; range 180-8910 lbs), which is 26% lower than strength at manufacture (mean 3530 SD 2224; range 650-12000 lbs). Median rope diameter was 3/8 inch. Right and @entity52287 were found in ropes with significantly stronger breaking strengths at manufacture than @entity10218 (4338 3850 and 2353 mean lbs, respectively). Adult right whales were found in stronger ropes (mean 7664 lbs) than juvenile right whales (mean 3446 lbs) and all @entity52287 age classes (mean 3906 lbs). For right whales, injuries have become more severe over the past three decades, possibly due to changes in rope manufacturing in the mid 1990's that resulted in stronger ropes at the same diameter. Our results suggest that broad adoption of ropes with breaking strengths of 1700 lbs or less could reduce the number of life-threatening entanglements for large whales by at least 72%, and still be strong enough to withstand the routine forces involved in many @entity9963 operations. A reduction of this magnitude would achieve nearly all of the mitigation legally required for US stocks of North Atlantic right and @entity52287 . Reduced breaking strength ropes should be developed and tested to determine the feasibility of its use in a variety of fisheries. This article is protected by copyright. All rights reserved.

title: Implications of XXXX rope strength on the severity of large whale entanglements.

entities_list: @entity52287 :: ('9773', 'Species') :: ['humpback whale', 'humpback whales']

answer: @entity9963 :: (MESH:D005393,Disease) :: ['fishing']


abstract: OBJECTIVE: This study determined the correlation between the levels of reactive @entity26 species (ROS) in prepared culture media and the early development of @entity1 embryos. MATERIALS AND METHODS: This was an autocontrolled comparison study. A total of 159 @entity1 undergoing in  vitro fertilization/intracytoplasmic sperm injection treatment were recruited in this study. The pH values, osmolarity pressures, and ROS levels of 15 batches of two culture media were measured. Sibling oocytes or embryos from individual @entity1 were randomly assigned to two culture groups with Quinn's Advantage Cleavage and Blastocyst media (QAC/QAB) or GIII series cleavage and blastocyst media (G1.3/G2.3). The difference between the two culture groups was analyzed using one-sample t test. RESULTS: The QAC/QAB and G1.3/G2.3 media exhibited similar pH values and osmolarity pressures. However, the prepared QAC/QAB media were characterized to contain lower amounts of ROS than the G1.3/G2.3 media. Furthermore, the blastocysts that developed under the QAC/QAB media were morphologically superior to those that developed under the G1.3/G2.3 media. CONCLUSION: The elevated ROS levels in culture media were associated with poor development of @entity5 . Measurement of ROS levels may be a valuable process for medium selection or modification.

title: Effects of reactive XXXX species levels in prepared culture media on embryo development: A comparison of two media.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['blastocyst-stage embryos']

answer: @entity26 :: (MESH:D010100,Chemical) :: ['oxygen']


abstract: OBJECTIVE: Use of vaginal meshes for treatment of @entity3577 ( @entity3577 ) remains controversial. A trend toward abdominal approaches and the development of new meshes has been noted. We compared the 1-year results of two different approaches using new lightweight meshes. MATERIALS AND METHODS: Sixty-nine (95.8%) of 72 @entity1 with @entity3577 Stage  >=   2, who underwent laparoscopic sacrocolpopexy (LSC) (n  =  39) or a total vaginal mesh (TVM) procedure (n  =  30) using lightweight @entity7502 meshes, were studied. Baseline and follow-up assessments included a pelvic examination and a composite condition-specific questionnaire. A detailed comparison of 1-year outcomes was made. Data were analyzed using appropriate statistical methods. RESULTS: Compared to the TVM group, the LSC group was characterized by a younger age (53.7 years vs. 64.1 years, p  <  0.001) and a longer operating time (264 minutes vs. 177.6 minutes, p  <  0.001). Objective anatomic success ( @entity3577 Stage   <=  1) rates were similar between groups after statistical adjustment, i.e., 84.6% (33/39) and 86.7% (26/30) after LSC and TVM (p  =  0.94), respectively. However, the dominant recurrence sites were different with anterior (n  =  6) most frequent after LSC and apical (n  =  4) most frequent after TVM. Reoperations were needed for the four (13.3%) apical recurrences in the TVM group. No serious complications were noted. We found "cystocele as the dominant prolapse" (p  =  0.016; odds ratio  =  6.94) and "suspension of prolapsed ( @entity3577 Stage  >=   2) uterus" (p  =  0.025; odds ratio  =  7.00) significantly affected recurrence after LSC and TVM, respectively. CONCLUSION: @entity3577 repair by LSC or TVM using the new lightweight @entity7502 meshes seems to be safe and has comparable outcomes, but limitations may vary.

title: A comparative study of laparoscopic sacrocolpopexy and total vaginal mesh procedure using lightweight XXXX meshes for prolapse repair.

entities_list: @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene']

entities_list: @entity3577 :: ('MESH:D056887', 'Disease') :: ['pelvic organ prolapse', 'POP']

answer: @entity7502 :: (MESH:D011126,Chemical) :: ['polypropylene']


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Hedyotis corymbosa (Linn.) Lam. is a small herb commonly called as khetpapra, traditionally used to treat a wide range of diseases including @entity490 , @entity625 and @entity32 . This study was conducted to evaluate the antinociceptive effect of @entity1068 extract of Hedyotis corymbosa (EEHC) whole plant. MATERIALS AND METHODS: The antinociceptive activity of EEHC was evaluated in @entity19 using both chemical- and heat-induced @entity158 models such as @entity1543 -induced writhing, hot plate, tail immersion, @entity406 , and @entity2227 tests at 50, 100, and 200mg/kg doses. In order to verify the possible involvement of opioid receptors in the central antinociceptive effect of EEHC, the effects found in hot plate and tail immersion tests were antagonized with @entity1510 . RESULTS: EEHC produced a dose-dependent antinociceptive effect against the chemical- and heat-induced @entity158 in @entity19 , significantly at 100 and 200mg/kg doses. These findings suggest that the action of EEHC involves both peripheral and central antinociceptive mechanisms. The antinociceptive activity of EEHC was significantly attenuated by pretreatment with @entity1510 , indicating the influence of opioid receptors on the exertion of EEHC action centrally. CONCLUSIONS: This study reports the antinociceptive activity of Hedyotis corymbosa and possible underlying mechanism(s) that supports the traditional use of this plant in the treatment of different @entity158 .

title: Evaluation of antinociceptive effect of XXXX extract of Hedyotis corymbosa Linn. whole plant in @entity19 .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity1510 :: ('MESH:D009270', 'Chemical') :: ['naloxone']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful conditions']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

answer: @entity1068 :: (MESH:D000431,Chemical) :: ['ethanol']


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Hedyotis corymbosa (Linn.) Lam. is a small herb commonly called as khetpapra, traditionally used to treat a wide range of diseases including @entity490 , @entity625 and @entity32 . This study was conducted to evaluate the antinociceptive effect of @entity1068 extract of Hedyotis corymbosa (EEHC) whole plant. MATERIALS AND METHODS: The antinociceptive activity of EEHC was evaluated in @entity19 using both chemical- and heat-induced @entity158 models such as @entity1543 -induced writhing, hot plate, tail immersion, @entity406 , and @entity2227 tests at 50, 100, and 200mg/kg doses. In order to verify the possible involvement of opioid receptors in the central antinociceptive effect of EEHC, the effects found in hot plate and tail immersion tests were antagonized with @entity1510 . RESULTS: EEHC produced a dose-dependent antinociceptive effect against the chemical- and heat-induced @entity158 in @entity19 , significantly at 100 and 200mg/kg doses. These findings suggest that the action of EEHC involves both peripheral and central antinociceptive mechanisms. The antinociceptive activity of EEHC was significantly attenuated by pretreatment with @entity1510 , indicating the influence of opioid receptors on the exertion of EEHC action centrally. CONCLUSIONS: This study reports the antinociceptive activity of Hedyotis corymbosa and possible underlying mechanism(s) that supports the traditional use of this plant in the treatment of different @entity158 .

title: Evaluation of antinociceptive effect of @entity1068 extract of Hedyotis corymbosa Linn. whole plant in XXXX .

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: BACKGROUND: @entity169 repair is one of the most performed surgeries in the world. It is recognized that any surgery of the pelvic floor may represent a risk factor of @entity4810 . METHOD: Retrospective study of @entity1 with @entity3893 and a history of adult @entity169 surgery and referred to our center between January 1990 and January 2011 for @entity249 . RESULTS: Among 69 @entity3893 @entity1 with history of adult @entity169 surgery, 60 @entity1 underwent surgical extraction of sperm that was successful in 75% (45/60). Positive extraction rate decreases in the subgroup of @entity1 with risk factors for @entity249 (61.4%) as well as in the group with @entity169 (67.9%). There was no statistically significant difference in the positive rate of sperm retrieval according to surgical technique or according to the use of @entity7502 mesh (P>0.05). CONCLUSION: The obstruction of the vas deferens due to an @entity169 was a potential iatrogenic cause of @entity4810 that was rare and underestimated. The influence of using a @entity7502 mesh was not clearly demonstrated. The management of these @entity1 is based on prevention in order to identify @entity1 with risk factors of @entity249 in order to propose a presurgery cryopreservation of sperm. LEVEL OF EVIDENCE: 5.

title: [ @entity3893 and a history of XXXX in adult].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity4810 :: ('MESH:D007248', 'Disease') :: ['male infertility']

entities_list: @entity169 :: ('MESH:D006552', 'Disease') :: ['bilateral inguinal hernia', 'inguinal hernia repair', 'Inguinal hernia']

entities_list: @entity3893 :: ('MESH:D053713', 'Disease') :: ['azoospermia']

answer: @entity169 :: (MESH:D006552,Disease) :: ['inguinal hernia repair']


abstract: BACKGROUND: @entity169 repair is one of the most performed surgeries in the world. It is recognized that any surgery of the pelvic floor may represent a risk factor of @entity4810 . METHOD: Retrospective study of @entity1 with @entity3893 and a history of adult @entity169 surgery and referred to our center between January 1990 and January 2011 for @entity249 . RESULTS: Among 69 @entity3893 @entity1 with history of adult @entity169 surgery, 60 @entity1 underwent surgical extraction of sperm that was successful in 75% (45/60). Positive extraction rate decreases in the subgroup of @entity1 with risk factors for @entity249 (61.4%) as well as in the group with @entity169 (67.9%). There was no statistically significant difference in the positive rate of sperm retrieval according to surgical technique or according to the use of @entity7502 mesh (P>0.05). CONCLUSION: The obstruction of the vas deferens due to an @entity169 was a potential iatrogenic cause of @entity4810 that was rare and underestimated. The influence of using a @entity7502 mesh was not clearly demonstrated. The management of these @entity1 is based on prevention in order to identify @entity1 with risk factors of @entity249 in order to propose a presurgery cryopreservation of sperm. LEVEL OF EVIDENCE: 5.

title: [ XXXX and a history of @entity169 in adult].

answer: @entity3893 :: (MESH:D053713,Disease) :: ['Azoospermia']


abstract: UNASSIGNED: @entity2998 ( @entity2998 ) has a fatal complication of @entity932 ( @entity932 ) associated with @entity1779 ( @entity1779 ), i.e. @entity932 and @entity510 ( @entity510 ). Although @entity510 accounts for a small percentage of these @entity1 , it is difficult to make a differential diagnosis of this syndrome from @entity1779 without @entity932 because the clinical presentations resemble each other. Furthermore, not only does the cause of @entity510 following @entity2998 remain unclear but also the role of controlling postoperative blood pressure is not detected in preventing @entity932 after @entity2998 . Herein, we report a case of @entity510 following @entity2998 and review previous literature to discuss the mechanism and the management of this fatal complication. A 78-year-old @entity1 with a history of @entity1294 and @entity583 was referred to our department for intervention to asymptomatic severe @entity850 of the right internal carotid artery. We performed @entity2998 under local anesthesia. Although her blood pressure was controlled to normotension during the procedure, the @entity1 complained of @entity10 following predilation. Postoperative emergent non-contrast computed tomography revealed @entity510 with leakage of contrast medium occupying the right sylvian fissure. We continued strict blood pressure control, and the @entity1 was discharged without any @entity51 . A well-opened lumen of the stent was recognized three months later at the outpatient visit. Strict control of intraoperative and postoperative blood pressure may improve the outcome of @entity510 following @entity2998 though the role in preventing @entity932 after @entity2998 is unclear.

title: Intraoperative XXXX during carotid artery stenting: A case report and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['brain hemorrhage', 'intracranial hemorrhage', 'ICH']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['SAH', 'subarachnoid hemorrhage']

entities_list: @entity1294 :: ('MESH:D015140', 'Disease') :: ['arteriosclerotic obliteration']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['CAS', 'Carotid artery stenting']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['cerebral hyperperfusion syndrome', 'CHS']

answer: @entity510 :: (MESH:D013345,Disease) :: ['idiopathic subarachnoid hemorrhage']


abstract: OBJECTIVE: Little is known about the long-term intellectual outcomes following @entity302 . Change is not likely within the first 2  years following surgery, and the few studies of longer term outcomes have yielded inconsistent results. This study addressed this issue by examining a large group of surgical and non-surgical @entity1 at baseline and after 4-11  years. METHODS: @entity1 were 97 @entity1 (mean age 20.08 [SD: 4.44]  years) with childhood-onset intractable @entity302 ; 61 had undergone resective @entity302 surgery. @entity1 underwent neuropsychological testing with the age-appropriate Wechsler Intelligence Scale, generating Full Scale, Performance and Verbal IQs, and Working Memory and Processing Speed indices. RESULTS: In total 54% of the surgical and 39% of the non-surgical @entity1 were @entity410 free in the preceding 12  months (p  >  .05); however, surgical @entity1 did achieve @entity410 freedom sooner and used fewer medications at follow-up. Surgical status was not associated with any cognitive domain. However, with the exception of processing speed, significant @entity410 status  *  time interaction effects were evident and @entity410 -free @entity1 had higher scores at follow-up. Regression analyses additionally showed that low pre-operative scores were predictive of improvement overtime, whereas high pre-operative scores were predictive of high scores at follow-up. INTERPRETATION: The results show similar intellectual outcomes for surgical and non-surgical paediatric @entity1 . Four to 11  years after @entity302 , @entity410 freedom, whether attained through @entity302 surgery or other means, was found to be associated with intellectual improvements. @entity410 status and baseline scores were the most consistent predictors.

title: Development of intelligence 4 to 11  years after XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Participants']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'Seizure']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'paediatric epilepsy surgery']

answer: @entity302 :: (MESH:D004827,Disease) :: ['paediatric epilepsy surgery']


abstract: UNASSIGNED: @entity8142 agonists ( @entity6757 RAs) are a new class of drugs that might have a potential beneficial effect on bone metabolism. Data on the effect of @entity6757 RAs and @entity174 risk are lacking. The aim of the present study was to investigate the association between the use of @entity6757 and the risk of @entity174 . A case-control study was performed using Danish National Health Service data. Cases were those who sustained a @entity174 and controls were those without a @entity174 during the study period (2007-2011), all aged 18  years and above. Conditional logistic regression estimated the odds ratios (OR) of @entity174 with current use of DPP4-I use. Analyses were adjusted for comorbidities and recent drug use. Among cases (n  =  229,114), there were 6993 current non-insulin anti- @entity6 drug (NIAD) users (excluding incretin users) and 255 @entity6757 RA users. Similarly, among controls (n  =  229,114), 7209 were NIAD users (excluding incretin users) and 220 were @entity6757 RA users. Current @entity6757 RA use was not associated with a decreased risk of @entity174 [adjusted (adj.) OR 1.16; 95  % CI 0.83-1.63]. @entity3604 risk was also not associated with current @entity6757 RA use (adj. OR 0.78; 95  % CI 0.44-1.39). In our nation-wide case-control study, we identified that the use of @entity6757 RA was not associated with @entity174 risk as compared to the use of other anti- @entity1602 drugs. Additionally, current @entity6757 RA use, stratified by cumulative or average daily dose, is not associated with @entity174 risk. Further research should focus on long-term use of @entity6757 RA and @entity174 risk.

title: Use of Glucagon-Like-Peptide 1 Receptor Agonists and Risk of @entity174 as Compared to Use of Other Anti- XXXX Drugs.

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['Osteoporotic fracture']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity8142 :: ('2740', 'Gene') :: ['Glucagon-like peptide-1 receptor']

entities_list: @entity1602 :: ('MESH:D006944', 'Disease') :: ['hyperglycemic']

answer: @entity1602 :: (MESH:D006944,Disease) :: ['hyperglycemic']


abstract: UNASSIGNED: @entity8142 agonists ( @entity6757 RAs) are a new class of drugs that might have a potential beneficial effect on bone metabolism. Data on the effect of @entity6757 RAs and @entity174 risk are lacking. The aim of the present study was to investigate the association between the use of @entity6757 and the risk of @entity174 . A case-control study was performed using Danish National Health Service data. Cases were those who sustained a @entity174 and controls were those without a @entity174 during the study period (2007-2011), all aged 18  years and above. Conditional logistic regression estimated the odds ratios (OR) of @entity174 with current use of DPP4-I use. Analyses were adjusted for comorbidities and recent drug use. Among cases (n  =  229,114), there were 6993 current non-insulin anti- @entity6 drug (NIAD) users (excluding incretin users) and 255 @entity6757 RA users. Similarly, among controls (n  =  229,114), 7209 were NIAD users (excluding incretin users) and 220 were @entity6757 RA users. Current @entity6757 RA use was not associated with a decreased risk of @entity174 [adjusted (adj.) OR 1.16; 95  % CI 0.83-1.63]. @entity3604 risk was also not associated with current @entity6757 RA use (adj. OR 0.78; 95  % CI 0.44-1.39). In our nation-wide case-control study, we identified that the use of @entity6757 RA was not associated with @entity174 risk as compared to the use of other anti- @entity1602 drugs. Additionally, current @entity6757 RA use, stratified by cumulative or average daily dose, is not associated with @entity174 risk. Further research should focus on long-term use of @entity6757 RA and @entity174 risk.

title: Use of Glucagon-Like-Peptide 1 Receptor Agonists and Risk of XXXX as Compared to Use of Other Anti- @entity1602 Drugs.

answer: @entity174 :: (MESH:D050723,Disease) :: ['Fracture']


abstract: BACKGROUND: Recent studies have suggested a strong association between @entity27 ( @entity27 ) and @entity955 ( @entity955 ). However, the impact of continuous positive airway pressure (CPAP) therapy on reverse @entity13678 in @entity1 with @entity27 is poorly understood. We aimed to determine the impact of CPAP therapy on total atrial conduction time measured by PA tissue Doppler imaging (TDI) interval in @entity1 without history of @entity955 . METHODS AND RESULTS: Thirty-five @entity1 with first diagnosed @entity27 (group 1) and 20 reference @entity1 without @entity27 (group 2) were prospectively enrolled. Group 1 was divided into 25 @entity1 with starting CPAP therapy (intervention group) and 10 @entity1 without CPAP therapy (control group). PA-TDI interval, measured by tissue Doppler imaging, and @entity3876 ( @entity3876 ) were determined at baseline and repeated after 30 days in group 1. @entity1 with @entity27 had a significantly longer PA-TDI interval (131.4  16.0ms vs. 120.1  6.4ms, p<0.001) compared to reference @entity1 . PA-TDI interval shortened significantly after 30 days of CPAP therapy (131  17.1ms vs. 124.6  15.7ms, p<0.001), whereas no significant change was found in the control group (132.6  13.6ms vs. 133.2  13.1ms, p=0.31) and @entity3876 -levels decreased significantly (39.1  50.7pg/ml vs. 28.2  42.4pg/ml, p<0.01), while @entity3876 -levels remained unaffected after 30 days in control group (31.5  20pg/ml vs. 34.4  20.5pg/ml, p=0.41). CONCLUSIONS: Change in PA-TDI interval, as an indirect surrogate marker of @entity13678 , suggests reverse @entity13678 in @entity1 with @entity27 and treated by CPAP. This effect may ensue from decreased atrial pressure or @entity1284 , as indicated by significantly reduced @entity3876 levels. These observations suggest that the substrate pre-disposing to @entity955 may be reversible and moreover can be measured by PA-TDI interval and @entity3876 .

title: Reverse Remodelling of the Atria After Treatment of XXXX with Continuous Positive Airway Pressure: Evidence from Electro-mechanical and Endocrine Markers.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity13678 :: ('MESH:D064752', 'Disease') :: ['atrial remodelling']

entities_list: @entity3876 :: ('4879', 'Gene') :: ['BNP', 'B-type natriuretic-peptide']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnoea', 'OSA']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity1284 :: ('MESH:D019190', 'Disease') :: ['volume overload']

answer: @entity27 :: (MESH:D020181,Disease) :: ['Obstructive Sleep Apnoea']


abstract: @entity10420 and @entity9496 have been thought to represent a single condition. Different clinical presentations for the disorders have been attributed to cultural stereotyping and diagnostic bias. The present study carefully examines detailed @entity146 histories taken from 560 nonpatient university students. Diagnoses of @entity10420 and @entity9496 are based on the diagnostic criteria for @entity146 research of Feighner et al. Interviewer bias is avoided. Both disorders were present in both sexes. @entity9496 was more common for women, whereas @entity10420 occurred more frequently in @entity1 . The two disorders presented with nearly equal frequency in @entity1 . @entity9496 was more frequent and @entity10420 was less frequent in @entity1 than in @entity1 . The two disorders were associated for @entity1 but not for @entity1 . Specific symptoms of @entity10420 were associated with @entity9496 and were identified. Specific symptoms of @entity9496 were associated with @entity10420 , differed in some respects between @entity1 and @entity1 , and demonstrated more symptoms of @entity308 for female sociopaths. @entity10420 , @entity9496 , and their combinations considered together as a possible single entity occurred with equal frequency for both sexes.

title: XXXX and @entity10420 . A single disorder?

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive illness']

entities_list: @entity10420 :: ('MESH:D000987', 'Disease') :: ['antisocial personality', 'Antisocial personality']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity9496 :: ('MESH:D007046', 'Disease') :: ['hysteria', 'Hysteria']

answer: @entity9496 :: (MESH:D007046,Disease) :: ['Hysteria']


abstract: @entity10420 and @entity9496 have been thought to represent a single condition. Different clinical presentations for the disorders have been attributed to cultural stereotyping and diagnostic bias. The present study carefully examines detailed @entity146 histories taken from 560 nonpatient university students. Diagnoses of @entity10420 and @entity9496 are based on the diagnostic criteria for @entity146 research of Feighner et al. Interviewer bias is avoided. Both disorders were present in both sexes. @entity9496 was more common for women, whereas @entity10420 occurred more frequently in @entity1 . The two disorders presented with nearly equal frequency in @entity1 . @entity9496 was more frequent and @entity10420 was less frequent in @entity1 than in @entity1 . The two disorders were associated for @entity1 but not for @entity1 . Specific symptoms of @entity10420 were associated with @entity9496 and were identified. Specific symptoms of @entity9496 were associated with @entity10420 , differed in some respects between @entity1 and @entity1 , and demonstrated more symptoms of @entity308 for female sociopaths. @entity10420 , @entity9496 , and their combinations considered together as a possible single entity occurred with equal frequency for both sexes.

title: @entity9496 and XXXX . A single disorder?

answer: @entity10420 :: (MESH:D000987,Disease) :: ['antisocial personality']


abstract: UNASSIGNED: @entity25933 ( @entity25933 / @entity48954 ) is a @entity1 @entity71803 with central roles in mRNA decay and translation repression. To help our understanding of how @entity25933 performs these multiple functions, we conducted the first unbiased, large-scale study to map the @entity25933 -centric protein-protein interactome using immunoprecipitation and mass spectrometry. Using @entity25933 as bait, we identify a high-confidence and high-quality set of protein interaction partners which are enriched for functions in RNA metabolism and ribosomal proteins. The screen is highly specific, maximizing the number of true positives, as demonstrated by the validation of 81% (47/58) of the RNA-independent interactors through known functions and interactions. Importantly, we minimize the number of indirect interaction partners through use of a nuclease-based digestion to eliminate RNA. We describe eleven new interactors, including proteins involved in splicing which is an as-yet unknown role for @entity25933 . We validated and characterized in more detail the interaction of @entity25933 with Nuclear @entity2100 -interacting protein 2 ( @entity62121 ) and with two previously uncharacterized proteins, @entity71804 and @entity71805 (here referred to as granulin-1 and granulin-2, or GRAN1 and GRAN2). We show that @entity62121 , GRAN1, and GRAN2 are not P-body components, but re-localize to stress granules upon exposure to stress, suggesting a function in translation repression in the cellular stress response. Using a complementary analysis that resolved @entity25933 's multiple complex memberships, we further validated these interaction partners and the presence of splicing factors. As @entity25933 also interacts with the E3 SUMO ligase @entity42364 , we tested for and observed a significant enrichment of sumoylation amongst @entity25933 's interaction partners. Our results represent the most comprehensive screen for direct interaction partners of a key regulator of RNA life cycle and localization, highlighting new stress granule components and possible @entity25933 functions-many of which are likely conserved across eukaryotes.

title: Comprehensive Protein Interactome Analysis of a Key XXXX : Detection of Novel Stress Granule Proteins.

entities_list: @entity2100 :: ('MESH:D005600', 'Disease') :: ['fragile X mental retardation']

answer: @entity71803 :: (55308,Gene) :: ['RNA Helicase']


abstract: BACKGROUND: @entity3918 type 1 ( @entity6045 ) is a rare disease. Creating registry for such a disease is of outstanding importance since it provides us with a full spectrum of the disorder. AIM: To assess variability of different multisystemic features in a large cohort of @entity1 with @entity6045 . @entity1 AND METHOD: Data from the Serbian registry for @entity3918 were used in the study. Final number of included @entity6045 subjects was 275. RESULTS: Registry included 53.8% of male @entity1 . Age at enrollment was 47.2        9.9years, mean disease duration 20.4        9.9years, and mean CTG repeats number 598.3        269.8.Progression of @entity425 was pretty slow, slower in proximal than distal muscles, and slower in arms than in legs. Severe ECG abnormality was found in 25.0% of @entity1 and pacemaker was implanted in 9.5%. Lens opacities were observed in 83.5% of @entity6045 @entity1 and 35.3% had @entity8814 . @entity209 were very common, while 19.5% of @entity1 had @entity1371 and 37.8% hypochloremia. Sterility was found in 20.5% of males and 4.1% of females. @entity2963 was found in 36.4% of @entity1 and @entity1142 in 29.9%. CONCLUSIONS: We defined the most common characteristics of our @entity6045 @entity1 and observed some treatable symptoms that have been neglected previously. Certain findings deserve further investigations in terms of their causes and consequences. Besides this, presented data analysis directs us to make further improvements of the Registry.

title: Variability of multisystemic features in XXXX type 1 - lessons from Serbian registry.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['muscle weakness']

entities_list: @entity8814 :: ('MESH:D015814', 'Disease') :: ['ocular hypotony']

entities_list: @entity2963 :: ('MESH:D002769', 'Disease') :: ['Cholelithiasis']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic disturbances']

entities_list: @entity3918 :: ('MESH:D009223', 'Disease') :: ['myotonic dystrophies', 'Myotonic dystrophy']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity1371 :: ('MESH:D007008', 'Disease') :: ['hypokalemia']

answer: @entity3918 :: (MESH:D009223,Disease) :: ['myotonic dystrophy']


abstract: @entity1466 is a highly malignant @entity5 of trophoblastic origin. @entity5274 is an extremely rare occurrence, especially in @entity1 over 50 years of age. This article concerns a case of @entity1466 developing in a 54-year-old @entity1 , which the authors present together with a brief review of the literature. The @entity1 presented with irregular @entity3556 for two months, following three months of @entity2588 . @entity530 (CT) scan showed an adnexal cystomic-solid mass. Her serum human chorionic gonadotropin ( @entity3566 ) levels were 29,1116 mIU/ml. The @entity1 underwent hysterectomy and bisalpingo-oophorectomy. Histology was suggestive of @entity1466 . Immunohistochemistry tests were positive for the @entity3566 , Ki 67, CK, @entity18069 , and negative for @entity5823 , supporting the diagnosis of @entity1466 . A combination of 5-Fu and KSM was administrated postoperatively. After four cycles of chemotherapy, her serum @entity3566 level fell to the normal range. The @entity1 remains disease-free 14 months after disease diagnosis.

title: Primary XXXX : a case report and literature review.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patient']

entities_list: @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding']

entities_list: @entity1466 :: ('MESH:D002822', 'Disease') :: ['Choriocarcinoma', 'tubal choriocarcinoma', 'choriocarcinoma']

entities_list: @entity530 :: ('MESH:D010386', 'Disease') :: ['Transvaginal dopolar and pelvic computed tomography']

entities_list: @entity5274 :: ('MESH:D005184', 'Disease') :: ['Primary fallopian tube choriocarcinoma']

entities_list: @entity2588 :: ('MESH:D000568', 'Disease') :: ['amenorrhea']

answer: @entity5274 :: (MESH:D005184,Disease) :: ['choriocarcinoma of the fallopian tube']


abstract: UNASSIGNED: Two of the most important challenges facing humanity in the 21st century comprise food production and disease control. Eco-friendly control tools against mosquito vectors and agricultural pests are urgently needed. Insecticidal products of marine origin have a huge potential to control these pests. In this research, we reported a single-step method to synthesize @entity575 nanoparticles (AgNP) using the aqueous leaf extract of the seaweed Hypnea musciformis, a cheap, nontoxic and eco-friendly material, that worked as reducing and stabilizing agent during the biosynthesis. The formation of AgNP was confirmed by surface plasmon resonance band illustrated in UV-vis spectrophotometer. AgNP were characterized by FTIR, SEM, EDX and XRD analyses. AgNP were mostly spherical in shape, crystalline in nature, with face-centered cubic geometry, and their mean size was 40-65nm. Low doses of H. musciformis aqueous extract and seaweed-synthesized @entity67307 showed larvicidal and @entity137 against the dengue vector @entity4224 and the @entity71806 . The LC50 value of AgNP ranged from 18.14 to 38.23ppm for 1st instar larvae (L1) and pupae of A. aegypti, and from 24.5 to 38.23ppm for L1 and pupae of P. xylostella. Both H. musciformis extract and AgNP strongly reduced longevity and fecundity of A. aegypti and P. xylostella adults. This study adds knowledge on the @entity137 of seaweed borne insecticides and green-synthesized AgNP against arthropods of medical and agricultural importance, allowing us to propose the tested products as effective candidates to develop newer and cheap pest control tools.

title: Characterization and biotoxicity of Hypnea musciformis-synthesized XXXX nanoparticles as potential eco-friendly control tool against @entity4224 and Plutella xylostella.

entities_list: @entity71806 :: ('MESH:D029021', 'Disease') :: ['cabbage pest Plutella xylostella']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'pupicidal toxicity']

entities_list: @entity4224 :: ('7159', 'Species') :: ['Aedes aegypti']

answer: @entity575 :: (MESH:D012834,Chemical) :: ['silver']


abstract: UNASSIGNED: Two of the most important challenges facing humanity in the 21st century comprise food production and disease control. Eco-friendly control tools against mosquito vectors and agricultural pests are urgently needed. Insecticidal products of marine origin have a huge potential to control these pests. In this research, we reported a single-step method to synthesize @entity575 nanoparticles (AgNP) using the aqueous leaf extract of the seaweed Hypnea musciformis, a cheap, nontoxic and eco-friendly material, that worked as reducing and stabilizing agent during the biosynthesis. The formation of AgNP was confirmed by surface plasmon resonance band illustrated in UV-vis spectrophotometer. AgNP were characterized by FTIR, SEM, EDX and XRD analyses. AgNP were mostly spherical in shape, crystalline in nature, with face-centered cubic geometry, and their mean size was 40-65nm. Low doses of H. musciformis aqueous extract and seaweed-synthesized @entity67307 showed larvicidal and @entity137 against the dengue vector @entity4224 and the @entity71806 . The LC50 value of AgNP ranged from 18.14 to 38.23ppm for 1st instar larvae (L1) and pupae of A. aegypti, and from 24.5 to 38.23ppm for L1 and pupae of P. xylostella. Both H. musciformis extract and AgNP strongly reduced longevity and fecundity of A. aegypti and P. xylostella adults. This study adds knowledge on the @entity137 of seaweed borne insecticides and green-synthesized AgNP against arthropods of medical and agricultural importance, allowing us to propose the tested products as effective candidates to develop newer and cheap pest control tools.

title: Characterization and biotoxicity of Hypnea musciformis-synthesized @entity575 nanoparticles as potential eco-friendly control tool against XXXX and Plutella xylostella.

answer: @entity4224 :: (7159,Species) :: ['Aedes aegypti']


abstract: OBJECTIVE: To explore the relationship between continuous @entity882 and @entity295 in @entity1 with severe burns. METHODS: Clinical data of 148 severely @entity4808 @entity1 admitted to our,two burn centers from January 2007 to December 2011 and conforming to the study criteria were retrospectively analyzed. All @entity1 were divided into @entity295 group (n =44) and non- @entity295 group (n = 104) according to the presence or absence of @entity295 within @entity4808 ( @entity4808 ) 30. The data of age, gender, total burn area, full-thickness burn area, fluid infusion volume within post burn hour (PBH) 24, plasma concentration of calcium ion on @entity4808 1, plasma concentration of albumin on @entity4808 1, platelet count on @entity4808 1, acute physiology and chronic health evaluation (APACHE) II score on admission, the presence or absence of @entity1457 or @entity130 on admission, the presence or absence of @entity5642 ( @entity5642 ) within PBH 48, operation or no operation within @entity4808 3, @entity882 duration within @entity4808 10, and mortality were statistically compared between two groups to screen the independent risk factors of @entity295 . Data were processed with t test, chi-square test, single factor Logistic regression analysis, and multi-factor Logistic regression analysis. RESULTS: Between two groups, there were statistically significant differences in total burn area, full-thickness burn area, plasma concentration of calcium ion on @entity4808 1, plasma concentration of albumin on @entity4808 1, APACHE II score on admission, presence or absence of hypovolem- ic shock on admission, presence or absence of @entity130 on admission, presence or absence of @entity5642 within PBH 48, and mortality (with t values from 2.433 to 4.082,   2 values from 8. 818 to 31.528, P < 0.05 or P < 0.01). Furthermore, the duration of @entity882 within @entity4808 10 in @entity295 group was (5.2    2.4) d, which was significantly longer than that in non- @entity295 group [(2.9    1.9) d, t =6. 189, P <0.01]. There were no statistically significant differences in the other indexes between two groups (with t values from 0.971 to 1. 250,   2 values respectively 0. 054 and 1.529, P values above 0.05). Single factor and multi-factor Logistic regression analysis indicated that APACHE II score on admission and duration of @entity882 within @entity4808 10 were closely related to occurrence of @entity295 (with odds ratio respectively 1. 140 and 1.569, P values below 0.01). CONCLUSIONS: Duration of @entity882 within @entity4808 10 is one of the risk factors for @entity295 in severely @entity4808 @entity1 , which can reflect pathophysiological changes in the body, thus providing predictive value for the occurrence of @entity295 .

title: [Clinical significance of continuous @entity882 in predicting XXXX after severe burn].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['hypovolemic shock']

entities_list: @entity5642 :: ('MESH:D004211', 'Disease') :: ['DIC', 'disseminated intravascular coagulation']

entities_list: @entity4808 :: ('MESH:D002056', 'Disease') :: ['post burn day', 'PBD', 'burned']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['inhalation injury']

answer: @entity295 :: (MESH:D018805,Disease) :: ['sepsis']