abstract: @entity9409 ( @entity9409 ) was shown to lower blood pressure in @entity35 models of @entity101 . Thus, there is evidence that-besides its chelating properties- @entity9409 has a direct vascular effect, e.g. through scavenging of reactive @entity26 species (ROS). We speculated that, in addition, intracellular @entity460 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9409 on @entity141 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity35 aorta. Intracellular free @entity141 concentration ([ @entity141 ](i)) was measured with @entity593 AM. In a first series of experiments @entity9409 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity141 ](i) (P<0.001) which was almost completely blunted by the @entity460 channel blocker @entity1855 or the intracellular @entity460 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9409 (10(-11) to 10(-6)M), the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9409 . Preincubation of VSMCs with @entity9409 (10(-6)M) for 60min reduced basal [ @entity141 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9409 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) by 66%, @entity9409 (10(-6)M) had no additional suppressive effect on [ @entity141 ](i). The results suggest that @entity9409 acutely raises [ @entity141 ](i) by stimulating transmembrane @entity460 influx via L-type @entity460 channels and by @entity460 release from intracellular stores followed by a decrease in [ @entity141 ](i) probably due to cellular @entity460 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity1808 , @entity9409 may exert its @entity551 effect through decreasing total cell @entity460 , thereby attenuating the vasoconstrictor-induced rise in [ @entity141 ](i) in VSMCs.

title: Interaction of @entity9409 ( @entity9409 ) with @entity1808 on XXXX mobilization in vascular smooth muscle cells.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['arterial hypertension']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1855 :: ('MESH:D014700', 'Chemical') :: ['verapamil']

entities_list: @entity9409 :: ('MESH:D004113', 'Chemical') :: ['DMSA', 'Dimercaptosuccinic acid']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: @entity9409 ( @entity9409 ) was shown to lower blood pressure in @entity35 models of @entity101 . Thus, there is evidence that-besides its chelating properties- @entity9409 has a direct vascular effect, e.g. through scavenging of reactive @entity26 species (ROS). We speculated that, in addition, intracellular @entity460 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9409 on @entity141 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity35 aorta. Intracellular free @entity141 concentration ([ @entity141 ](i)) was measured with @entity593 AM. In a first series of experiments @entity9409 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity141 ](i) (P<0.001) which was almost completely blunted by the @entity460 channel blocker @entity1855 or the intracellular @entity460 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9409 (10(-11) to 10(-6)M), the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9409 . Preincubation of VSMCs with @entity9409 (10(-6)M) for 60min reduced basal [ @entity141 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9409 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) by 66%, @entity9409 (10(-6)M) had no additional suppressive effect on [ @entity141 ](i). The results suggest that @entity9409 acutely raises [ @entity141 ](i) by stimulating transmembrane @entity460 influx via L-type @entity460 channels and by @entity460 release from intracellular stores followed by a decrease in [ @entity141 ](i) probably due to cellular @entity460 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity1808 , @entity9409 may exert its @entity551 effect through decreasing total cell @entity460 , thereby attenuating the vasoconstrictor-induced rise in [ @entity141 ](i) in VSMCs.

title: Interaction of XXXX ( @entity9409 ) with @entity1808 on @entity460 mobilization in vascular smooth muscle cells.

answer: @entity9409 :: (MESH:D004113,Chemical) :: ['dimercaptosuccinic acid']


abstract: @entity9409 ( @entity9409 ) was shown to lower blood pressure in @entity35 models of @entity101 . Thus, there is evidence that-besides its chelating properties- @entity9409 has a direct vascular effect, e.g. through scavenging of reactive @entity26 species (ROS). We speculated that, in addition, intracellular @entity460 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9409 on @entity141 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity35 aorta. Intracellular free @entity141 concentration ([ @entity141 ](i)) was measured with @entity593 AM. In a first series of experiments @entity9409 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity141 ](i) (P<0.001) which was almost completely blunted by the @entity460 channel blocker @entity1855 or the intracellular @entity460 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9409 (10(-11) to 10(-6)M), the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9409 . Preincubation of VSMCs with @entity9409 (10(-6)M) for 60min reduced basal [ @entity141 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9409 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) by 66%, @entity9409 (10(-6)M) had no additional suppressive effect on [ @entity141 ](i). The results suggest that @entity9409 acutely raises [ @entity141 ](i) by stimulating transmembrane @entity460 influx via L-type @entity460 channels and by @entity460 release from intracellular stores followed by a decrease in [ @entity141 ](i) probably due to cellular @entity460 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity1808 , @entity9409 may exert its @entity551 effect through decreasing total cell @entity460 , thereby attenuating the vasoconstrictor-induced rise in [ @entity141 ](i) in VSMCs.

title: Interaction of @entity9409 ( XXXX ) with @entity1808 on @entity460 mobilization in vascular smooth muscle cells.

answer: @entity9409 :: (MESH:D004113,Chemical) :: ['DMSA']


abstract: @entity9409 ( @entity9409 ) was shown to lower blood pressure in @entity35 models of @entity101 . Thus, there is evidence that-besides its chelating properties- @entity9409 has a direct vascular effect, e.g. through scavenging of reactive @entity26 species (ROS). We speculated that, in addition, intracellular @entity460 mobilization may be involved in this action. Therefore, the present study examined the effects of @entity9409 on @entity141 mobilization in cultured vascular smooth muscle cells (VSMCs) from @entity35 aorta. Intracellular free @entity141 concentration ([ @entity141 ](i)) was measured with @entity593 AM. In a first series of experiments @entity9409 , 10(-11) to 10(-6)M, induced an immediate dose-dependent up to 4-fold rise of [ @entity141 ](i) (P<0.001) which was almost completely blunted by the @entity460 channel blocker @entity1855 or the intracellular @entity460 release blocker TMB-8. In a second series of experiments, when VSMCs were exposed acutely to @entity9409 (10(-11) to 10(-6)M), the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) to 295+/-40nM was attenuated at the average by 49% independent of the dose of @entity9409 . Preincubation of VSMCs with @entity9409 (10(-6)M) for 60min reduced basal [ @entity141 ](i) by 77% (P<0.001) and dose-dependently attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) between 28 and 69% at concentrations between 10(-9) and 10(-5)M @entity9409 , respectively (P<0.05 and <0.01). In the presence of TMB-8, which attenuated the @entity1808 (10(-8)M)-induced rise in [ @entity141 ](i) by 66%, @entity9409 (10(-6)M) had no additional suppressive effect on [ @entity141 ](i). The results suggest that @entity9409 acutely raises [ @entity141 ](i) by stimulating transmembrane @entity460 influx via L-type @entity460 channels and by @entity460 release from intracellular stores followed by a decrease in [ @entity141 ](i) probably due to cellular @entity460 depletion. Thus, in addition to its action as scavenger of ROS, which in part mediate the vasoconstrictor response, e.g. to @entity1808 , @entity9409 may exert its @entity551 effect through decreasing total cell @entity460 , thereby attenuating the vasoconstrictor-induced rise in [ @entity141 ](i) in VSMCs.

title: Interaction of @entity9409 ( @entity9409 ) with XXXX on @entity460 mobilization in vascular smooth muscle cells.

answer: @entity1808 :: (24179(Tax:10116),Gene) :: ['angiotensin II']


abstract: The optimal management of asparaginase-associated @entity715 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity1 with @entity981 ( @entity981 ) with asparaginase-related @entity1211 ( @entity1211 ) treated at Dana-Farber @entity5 Institute on clinical trials for newly diagnosed @entity981 between 1991-2008. Of 548 @entity1 , 43 (8%) had @entity1211 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity1 . @entity50 occurred in 1  6% of @entity1 . Age was the only significant predictor of @entity1211 , with those aged >30years at very high risk ( @entity1211 rate 42%). 74% of @entity1 received low molecular weight heparin after @entity1211 . Complications of anticoagulation included @entity1415 (9%), @entity2981 (2%) and, in two adult @entity1 , major @entity548 . Thirty @entity1 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity1 experienced recurrent @entity1211 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity1 with @entity1211 was 85  6% compared with 88  2% for those without @entity1211 (P=0  36). This study confirms that, after @entity1211 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity1211 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related @entity715 in paediatric and adult @entity1 with XXXX treated on Dana-Farber @entity5 Institute consortium protocols.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoblastic leukaemia', 'ALL']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity1415 :: ('MESH:D004844', 'Disease') :: ['epistaxis']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolic events']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['Sinus venous thrombosis']

answer: @entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukaemia']


abstract: The optimal management of asparaginase-associated @entity715 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity1 with @entity981 ( @entity981 ) with asparaginase-related @entity1211 ( @entity1211 ) treated at Dana-Farber @entity5 Institute on clinical trials for newly diagnosed @entity981 between 1991-2008. Of 548 @entity1 , 43 (8%) had @entity1211 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity1 . @entity50 occurred in 1  6% of @entity1 . Age was the only significant predictor of @entity1211 , with those aged >30years at very high risk ( @entity1211 rate 42%). 74% of @entity1 received low molecular weight heparin after @entity1211 . Complications of anticoagulation included @entity1415 (9%), @entity2981 (2%) and, in two adult @entity1 , major @entity548 . Thirty @entity1 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity1 experienced recurrent @entity1211 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity1 with @entity1211 was 85  6% compared with 88  2% for those without @entity1211 (P=0  36). This study confirms that, after @entity1211 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity1211 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related XXXX in paediatric and adult @entity1 with @entity981 treated on Dana-Farber @entity5 Institute consortium protocols.

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombosis']


abstract: The optimal management of asparaginase-associated @entity715 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity1 with @entity981 ( @entity981 ) with asparaginase-related @entity1211 ( @entity1211 ) treated at Dana-Farber @entity5 Institute on clinical trials for newly diagnosed @entity981 between 1991-2008. Of 548 @entity1 , 43 (8%) had @entity1211 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity1 . @entity50 occurred in 1  6% of @entity1 . Age was the only significant predictor of @entity1211 , with those aged >30years at very high risk ( @entity1211 rate 42%). 74% of @entity1 received low molecular weight heparin after @entity1211 . Complications of anticoagulation included @entity1415 (9%), @entity2981 (2%) and, in two adult @entity1 , major @entity548 . Thirty @entity1 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity1 experienced recurrent @entity1211 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity1 with @entity1211 was 85  6% compared with 88  2% for those without @entity1211 (P=0  36). This study confirms that, after @entity1211 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity1211 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related @entity715 in paediatric and adult @entity1 with @entity981 treated on Dana-Farber XXXX Institute consortium protocols.

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: The optimal management of asparaginase-associated @entity715 complications is not well-defined. We report the features, management and outcome of paediatric (ages 0-18years) and adult (18-50years) @entity1 with @entity981 ( @entity981 ) with asparaginase-related @entity1211 ( @entity1211 ) treated at Dana-Farber @entity5 Institute on clinical trials for newly diagnosed @entity981 between 1991-2008. Of 548 @entity1 , 43 (8%) had @entity1211 , including 27/501 (5%) paediatric and 16/47 (34%) adult @entity1 . @entity50 occurred in 1  6% of @entity1 . Age was the only significant predictor of @entity1211 , with those aged >30years at very high risk ( @entity1211 rate 42%). 74% of @entity1 received low molecular weight heparin after @entity1211 . Complications of anticoagulation included @entity1415 (9%), @entity2981 (2%) and, in two adult @entity1 , major @entity548 . Thirty @entity1 (70%) ultimately received at least 85% of the intended doses of asparaginase. 33% of @entity1 experienced recurrent @entity1211 (paediatric 17% vs. adults 47%, P=0  07). The 48-month event-free survival for @entity1 with @entity1211 was 85  6% compared with 88  2% for those without @entity1211 (P=0  36). This study confirms that, after @entity1211 , asparaginase can be restarted with closely monitored anticoagulation after imaging demonstrates clot stabilization or improvement. With this management strategy, a history of @entity1211 does not appear to adversely impact prognosis.

title: The frequency and management of asparaginase-related @entity715 in paediatric and adult XXXX with @entity981 treated on Dana-Farber @entity5 Institute consortium protocols.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION: Few couple-focused interventions have been developed to improve distress and relationship outcomes among @entity1 diagnosed with @entity263 and their partners. AIMS: We examined the effects of a five-session Intimacy-Enhancing Therapy (IET) vs. Usual Care (UC) on the psychological and relationship functioning of @entity1 diagnosed with @entity263 and their partners. Pre-intervention levels of psychological and relationship functioning were evaluated as moderators of intervention effects. METHODS: Seventy-one survivors and their partners completed a baseline survey and were subsequently randomly assigned to receive five sessions of IET or UC (no treatment). Eight weeks after the baseline assessment, a follow-up survey was administered to survivor and partner. MAIN OUTCOME MEASURES: Distress, well-being, relationship satisfaction, relationship intimacy, and communication were investigated as the main outcomes. RESULTS: IET effects were largely moderated by pre-intervention psychosocial and relationship factors. Those survivors who had higher levels of @entity5 concerns at pretreatment had significantly reduced concerns following IET. Similar moderating effects for pre-intervention levels were reported for the effects of IET on self-disclosure, perceived partner disclosure, and perceived partner responsiveness. Among partners beginning the intervention with higher @entity5 , lower marital satisfaction, lower intimacy, and poorer communication, IET improved these outcomes. CONCLUSIONS: IET had a marginally significant main effect upon survivor well-being but was effective among couples with fewer personal and relationship resources. Subsequent research is needed to replicate these findings with a larger sample and a longer follow-up.

title: Intimacy-enhancing psychological intervention for @entity1 diagnosed with XXXX and their partners: a pilot study.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['localized prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cancer-specific distress']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: INTRODUCTION: Few couple-focused interventions have been developed to improve distress and relationship outcomes among @entity1 diagnosed with @entity263 and their partners. AIMS: We examined the effects of a five-session Intimacy-Enhancing Therapy (IET) vs. Usual Care (UC) on the psychological and relationship functioning of @entity1 diagnosed with @entity263 and their partners. Pre-intervention levels of psychological and relationship functioning were evaluated as moderators of intervention effects. METHODS: Seventy-one survivors and their partners completed a baseline survey and were subsequently randomly assigned to receive five sessions of IET or UC (no treatment). Eight weeks after the baseline assessment, a follow-up survey was administered to survivor and partner. MAIN OUTCOME MEASURES: Distress, well-being, relationship satisfaction, relationship intimacy, and communication were investigated as the main outcomes. RESULTS: IET effects were largely moderated by pre-intervention psychosocial and relationship factors. Those survivors who had higher levels of @entity5 concerns at pretreatment had significantly reduced concerns following IET. Similar moderating effects for pre-intervention levels were reported for the effects of IET on self-disclosure, perceived partner disclosure, and perceived partner responsiveness. Among partners beginning the intervention with higher @entity5 , lower marital satisfaction, lower intimacy, and poorer communication, IET improved these outcomes. CONCLUSIONS: IET had a marginally significant main effect upon survivor well-being but was effective among couples with fewer personal and relationship resources. Subsequent research is needed to replicate these findings with a larger sample and a longer follow-up.

title: Intimacy-enhancing psychological intervention for XXXX diagnosed with @entity263 and their partners: a pilot study.

answer: @entity1 :: (9606,Species) :: ['men']


abstract: This study was aimed to investigate the fundus changes of @entity1 with pregnancy-induced @entity101 syndrome (PIHS) using optical coherence tomography (OCT) technology and @entity8 ( @entity8 ) tests.Ninety-eight @entity1 with PIHS underwent routine eye examinations including vision correction, fundus examination, OCT, and @entity8 tests. The @entity8 test was performed at low, medium, and high frequency, respectively. Moreover, the difference in @entity8 tests between 2 groups was analyzed by independent-samples T test. The Kruskal-Wallis rank sum test and linear regression model were used to detect the correlation of OCT with @entity8 , respectively. Meanwhile Satterthwaite approximate T test was adopted for pairwise comparisons after nonparametric analysis of variance.The OCT test revealed that 56.76% of the examined eyes showed shallow @entity1713 in the macula lutea and around the optic disk. The differences in @entity8 at each spatial frequency between the case and control group were statistically significant (P<0.01). Besides, OCT manifestations were associated with @entity8 at each spacial frequency including 1.5, 3, 6, 12, and 18 frequency (P<0.01). And @entity1 with abnormal manifestations of OCT showed lower @entity8 at each spacial frequency than those without abnormal OCT manifestations. What's more the OCT manifestation 1 showed the greatest impact on @entity8 at each spacial frequency.The results showed that abnormal OCT manifestations were correlated with @entity8 in PIHS. OCT and @entity8 tests might be valuable methods in observing fundus changes for PIHS @entity1 .

title: Application of Optical Coherence Tomography and Contrast Sensitivity Test for Observing Fundus Changes of @entity1 With XXXX .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['CS', 'contrast sensitivity']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1713 :: ('MESH:D012163', 'Disease') :: ['retinal detachment']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Pregnancy-Induced Hypertension Syndrome']


abstract: This study was aimed to investigate the fundus changes of @entity1 with pregnancy-induced @entity101 syndrome (PIHS) using optical coherence tomography (OCT) technology and @entity8 ( @entity8 ) tests.Ninety-eight @entity1 with PIHS underwent routine eye examinations including vision correction, fundus examination, OCT, and @entity8 tests. The @entity8 test was performed at low, medium, and high frequency, respectively. Moreover, the difference in @entity8 tests between 2 groups was analyzed by independent-samples T test. The Kruskal-Wallis rank sum test and linear regression model were used to detect the correlation of OCT with @entity8 , respectively. Meanwhile Satterthwaite approximate T test was adopted for pairwise comparisons after nonparametric analysis of variance.The OCT test revealed that 56.76% of the examined eyes showed shallow @entity1713 in the macula lutea and around the optic disk. The differences in @entity8 at each spatial frequency between the case and control group were statistically significant (P<0.01). Besides, OCT manifestations were associated with @entity8 at each spacial frequency including 1.5, 3, 6, 12, and 18 frequency (P<0.01). And @entity1 with abnormal manifestations of OCT showed lower @entity8 at each spacial frequency than those without abnormal OCT manifestations. What's more the OCT manifestation 1 showed the greatest impact on @entity8 at each spacial frequency.The results showed that abnormal OCT manifestations were correlated with @entity8 in PIHS. OCT and @entity8 tests might be valuable methods in observing fundus changes for PIHS @entity1 .

title: Application of Optical Coherence Tomography and Contrast Sensitivity Test for Observing Fundus Changes of XXXX With @entity101 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Streptococci and actinomyces that initiate colonization of the tooth surface frequently coaggregate with each other as well as with other oral bacteria. These observations have led to the hypothesis that interbacterial adhesion influences spatiotemporal development of plaque. To assess the role of such interactions in oral biofilm formation in vivo, antibodies directed against bacterial surface components that mediate coaggregation interactions were used as direct immunofluorescent probes in conjunction with laser confocal microscopy to determine the distribution and spatial arrangement of bacteria within intact @entity1 plaque formed on retrievable enamel chips. In intrageneric coaggregation, streptococci such as @entity9190 @entity15974 recognize @entity16290 ( @entity16290 ) borne on other streptococci such as @entity9858 34. To define potentially interactive subsets of streptococci in the developing plaque, an antibody against @entity16290 (anti- @entity16290 ) was used together with an antibody against S. gordonii @entity15974 ( @entity15974 ). These antibodies reacted primarily with single cells in 4-h-old plaque and with mixed-species microcolonies in 8-h-old plaque. Anti- @entity16290 -reactive bacteria frequently formed microcolonies with anti- @entity15974 -reactive bacteria and with other bacteria distinguished by general nucleic acid stains. In intergeneric coaggregation between streptococci and actinomyces, type 2 fimbriae of actinomyces recognize @entity16290 on the streptococci. Cells reactive with antibody against type 2 fimbriae of Actinomyces naeslundii @entity37899 (anti-type-2) were much less frequent than either subset of streptococci. However, bacteria reactive with anti-type-2 were seen in intimate association with anti- @entity16290 -reactive cells. These results are the first direct demonstration of coaggregation-mediated interactions during initial plaque accumulation in vivo. Further, these results demonstrate the spatiotemporal development and prevalence of mixed-species communities in @entity2413 .

title: Coaggregation-mediated interactions of streptococci and actinomyces detected in initial XXXX dental plaque.

entities_list: @entity9858 :: ('1303', 'Species') :: ['Streptococcus oralis']

entities_list: @entity2413 :: ('MESH:D003773', 'Disease') :: ['early dental plaque']

entities_list: @entity16290 :: ('MESH:C564877', 'Disease') :: ['RPS', 'receptor polysaccharides']

entities_list: @entity9190 :: ('1302', 'Species') :: ['Streptococcus gordonii']

entities_list: @entity37899 :: ('p|SUB|T|14|V', 'ProteinMutation') :: ['T14V']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Quantification of programmed and accidental cell death provides useful end-points for the anticancer drug efficacy assessment. Cell death is, however, a stochastic process. Therefore, the opportunity to dynamically quantify individual cellular states is advantageous over the commonly employed static, end-point assays. In this work, we describe the development and application of a microfabricated, dielectrophoretic (DEP) cell immobilization platform for the real-time analysis of @entity5 drug-induced @entity137 . Microelectrode arrays were designed to generate weak electro-thermal vortices that support efficient drug mixing and rapid cell immobilization at the delta-shape regions of strong electric field formed between the opposite microelectrodes. We applied this technology to the dynamic analysis of @entity1583 cells that represent a particular challenge for real-time imaging due to their dislodgement during image acquisition. The present study was designed to provide a comprehensive mechanistic rationale for accelerated cell-based assays on DEP chips using real-time labeling with cell permeability markers. In this context, we provide data on the complex behavior of viable vs dying cells in the DEP fields and probe the effects of DEP fields upon cell responses to anticancer drugs and overall bioassay performance. Results indicate that simple DEP cell immobilization technology can be readily applied for the dynamic analysis of investigational drugs in @entity5 cells. This ability is of particular importance in studying the outcome of @entity1 derived @entity5 cells, when exposed to therapeutic drugs, as these cells are often rare and difficult to collect, purify and immobilize.

title: Dynamic analysis of drug-induced XXXX using chip-based dielectrophoretic cell immobilization technology.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['hematopoietic cancer', 'cancer']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematopoietic tumor']

answer: @entity137 :: (MESH:D064420,Disease) :: ['cytotoxicity']


abstract: OBJECTIVE: To describe the radiographic cervical spine changes in @entity309 @entity1 . METHODS: Forty-nine @entity1 (37 females and 12 males) diagnosed with @entity309 at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia, between June 1998 and June 2000, were studied for their radiographic cervical spine changes. Their mean age at disease onset was 41.4 +/- 13.4 years (range of 18-73) and mean duration of the disease was 9.1 +/- 6.28 years (range of 2-34). Their demographic data including rheumatoid factor status was obtained. Standard conventional radiographs of cervical spine were obtained to study the cervical spine changes. RESULTS: Cervical spine radiographic changes were found in 34 @entity1 (27 females and 7 males), 10 had subluxation (7 with atlanto-axial subluxation, 2 with sub-axial subluxation, and one with lateral subluxation). No vertical @entity3355 was seen. Erosion of odontoid process was seen in one @entity1 . All were rheumatoid seropositive. CONCLUSION: Cervical spine changes in @entity1 with @entity309 are common, in particular subluxation in the upper cervical spine. Our study showed somewhat lesser prevalence of these changes. These were clinically correlated with disease duration, female sex, and rheumatoid factor, but were not statistically significant.

title: XXXX . Radiological changes in the cervical spine.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

entities_list: @entity3355 :: ('MESH:D014095', 'Disease') :: ['impaction']

answer: @entity309 :: (MESH:D001172,Disease) :: ['Rheumatoid arthritis']


abstract: DNA aneuploidy is a biological marker of the oncogenic potential of @entity2513 . The accumulation of genetic alterations of @entity5 -related genes is also essential for @entity14 . However, it is unclear whether there is any relationship between these genetic alterations and the DNA ploidy of @entity5 cells in the progression of @entity2513 and early @entity14 . Here we have studied the DNA ploidy state and genetic alterations occurring in @entity14 using the crypt isolation technique. Crypts isolated from a total of 106 @entity14 ( @entity652 , 93; early @entity189 , 13) were examined using a combination of flow cytometric analysis of DNA content, polymerase chain reaction-microsatellite assay, and single-strand conformation polymorphism assay for evidence of chromosomal allelic imbalance (AI; 17p; 5q; 18q) or @entity876 gene mutation. In addition, we examined @entity124 ( @entity124 ) with BAT 26 primer sets. DNA multiploidy was infrequently detected in @entity2513 (15.1%), in contrast to early @entity189 (46.2%). There was a significant difference in the incidence of AI of chromosome 18q between diploid @entity652 and @entity2007 populations of multiploid @entity652 (18.1% vs 57.1%, p = 0.0043). Mutation of @entity876 was also found more frequently in @entity2007 populations of early multiploid @entity14 than in early diploid @entity14 (66.7% vs 0%, p = 0.021). @entity124 was found in only 2 of 93 @entity652 , with no @entity124 detected in early @entity14 . The two @entity124 -positive @entity652 were diploid. We subdivided multiploid @entity652 into two groups: those with a low or a high @entity894 ( @entity894 ). The incidence of genetic alterations of high- @entity894 @entity652 did not differ from those of low- @entity894 @entity652 . Allelic imbalance involving loci on chromosome 18q and mutations of @entity876 seems to be associated with the progression of diploidy to multiploidy in @entity14 . On the other hand, @entity124 may be associated with the development of some @entity5 . In addition, the incidence of genetic alterations in the @entity2513 that we examined appears to be independent of the @entity5 's @entity894 .

title: Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of XXXX and early @entity14 .

entities_list: @entity124 :: ('MESH:D053842', 'Disease') :: ['MSI', 'microsatellite instability']

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploid']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'diploid tumours', 'cancer', 'colon tumour']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'carcinoma']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancers', 'colorectal carcinogenesis', 'colorectal tumors', 'colorectal tumours', 'colorectal carcinomas']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas', 'adenoma']

entities_list: @entity2513 :: ('MESH:C563365', 'Disease') :: ['colorectal adenomas']

answer: @entity2513 :: (MESH:C563365,Disease) :: ['colorectal adenomas']


abstract: DNA aneuploidy is a biological marker of the oncogenic potential of @entity2513 . The accumulation of genetic alterations of @entity5 -related genes is also essential for @entity14 . However, it is unclear whether there is any relationship between these genetic alterations and the DNA ploidy of @entity5 cells in the progression of @entity2513 and early @entity14 . Here we have studied the DNA ploidy state and genetic alterations occurring in @entity14 using the crypt isolation technique. Crypts isolated from a total of 106 @entity14 ( @entity652 , 93; early @entity189 , 13) were examined using a combination of flow cytometric analysis of DNA content, polymerase chain reaction-microsatellite assay, and single-strand conformation polymorphism assay for evidence of chromosomal allelic imbalance (AI; 17p; 5q; 18q) or @entity876 gene mutation. In addition, we examined @entity124 ( @entity124 ) with BAT 26 primer sets. DNA multiploidy was infrequently detected in @entity2513 (15.1%), in contrast to early @entity189 (46.2%). There was a significant difference in the incidence of AI of chromosome 18q between diploid @entity652 and @entity2007 populations of multiploid @entity652 (18.1% vs 57.1%, p = 0.0043). Mutation of @entity876 was also found more frequently in @entity2007 populations of early multiploid @entity14 than in early diploid @entity14 (66.7% vs 0%, p = 0.021). @entity124 was found in only 2 of 93 @entity652 , with no @entity124 detected in early @entity14 . The two @entity124 -positive @entity652 were diploid. We subdivided multiploid @entity652 into two groups: those with a low or a high @entity894 ( @entity894 ). The incidence of genetic alterations of high- @entity894 @entity652 did not differ from those of low- @entity894 @entity652 . Allelic imbalance involving loci on chromosome 18q and mutations of @entity876 seems to be associated with the progression of diploidy to multiploidy in @entity14 . On the other hand, @entity124 may be associated with the development of some @entity5 . In addition, the incidence of genetic alterations in the @entity2513 that we examined appears to be independent of the @entity5 's @entity894 .

title: Analysis of genetic alterations, classified according to their DNA ploidy pattern, in the progression of @entity2513 and early XXXX .

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinomas']


abstract: The aim of this study was to estabilish whether subtle changes in regional cerebral blood flow ( @entity13279 ) can be detected in @entity1 with mild @entity195 ( @entity195 ) over a period as short as three months. Aprospective evaluation of @entity13279 changes with HMPAO SPECT at baseline and after 3 and 6 months was carried out. Standard clinical @entity303 tests were performed in parallel. The study enrolled 13 @entity1 with mild probable @entity195 from an outpatient memory clinic. SPECT data collected at baseline and after three months were compared using Statistical Parametric Mapping (SPM). Significant clusters of @entity13279 decrement in the medial part of the temporal lobe in both hemispheres, in the orbital part of the right frontal lobe and in the inferior part of the right parietal lobe were observed. No significant differences were found using a region of interest (ROI) analysis. After six months SPM analysis showed larger clusters of significant decrement in the same areas. ROI analysis was now sensitive to the @entity13279 changes and significant differences were shown in all brain regions except the temporal lobes. SPM analysis of SPECT data can detect significant changes in @entity13279 in mild @entity195 over a short time interval. This method might be of potential advantage for the early diagnosis of @entity195 and for its differentiation from stable @entity73 .

title: Short-term longitudinal evaluation of cerebral blood flow in mild XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairments']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']


abstract: Twenty-one @entity1 with @entity34 diagnosed between 1973 and 1983 were analyzed retrospectively. Median age at diagnosis was eleven months (1 week to 153 months). @entity5 was above the diaphragm in 67% and below the diaphragm in 33%. All @entity1 underwent surgical resection and pathologic diagnosis was @entity521 in 76% and @entity6012 in 24%. Regional lymph nodes were positive in three of eleven @entity1 sampled. Sixty-seven percent had gross @entity66 , and thirty-three percent had microscopic @entity66 . Seventeen @entity1 received postoperative irradiation and none has relapsed (median follow-up 57 months). Four @entity1 received surgery alone (median follow-up 24 months); one local relapse occurred in this group and was subsequently treated with irradiation. All @entity1 are alive and disease free, with a median length of follow-up of 55 months. Radiation dosage was 1000-1800 rad in @entity1 less than 12 months of age, and 1800-3000 rad in those greater than 12 months of age at diagnosis. The high disease-free survival rate in both groups of @entity1 , but especially in the group receiving adjuvant irradiation, emphasizes the need for a controlled, prospective study to determine which @entity34 @entity1 , if any, would be benefitted by postoperative irradiation.

title: XXXX --does adjuvant irradiation contribute to cure?

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity6012 :: ('MESH:D018305', 'Disease') :: ['ganglioneuroblastoma']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['residual disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Primary tumor']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma']

entities_list: @entity34 :: ('MESH:D016609', 'Disease') :: ['Stage II neuroblastoma']

answer: @entity34 :: (MESH:D016609,Disease) :: ['Stage II neuroblastoma']


abstract: DNA repair gene polymorphisms have been implicated as susceptibility factors in @entity5 development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. @entity72539 polymorphism in the DNA repair gene @entity20319 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of @entity5 development. Two hundred thirty-seven @entity957 ( @entity957 ) were included in a study to investigate the role of the @entity20319 194Trp, 280His, and 399Gln polymorphisms on @entity876 gene mutation. PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the conserved regions of the @entity876 gene (exons 5-9). The @entity20319 genotype was determined by PCR-RFLP. Nineteen (8.02%) of the 237 @entity957 had a @entity7647 / @entity7647 genotype. One hundred six (43.88%) of the 237 @entity957 showed @entity876 gene mutations at exons 5-9. The OSCC @entity1 with a @entity7647 / @entity7647 genotype exhibited a significantly higher frequency of @entity876 mutation than those with an @entity534 / @entity7647 and an Arg/Arg genotype. After adjustment for age, cigarette smoking, areca quid chewing, and @entity167 drinking, the @entity7647 / @entity7647 genotype still showed an independent association with the frequency of @entity876 mutation (odd ratio, 4.50; 95% confidence interval, 1.52-13.36). The findings support the hypothesis that @entity20319 @entity20322 @entity535 change may alter the phenotype of the @entity20319 protein, resulting in a DNA repair deficiency. This study also suggests an important role for the @entity20319 399Gln polymorphism in @entity876 gene mutation in Taiwanese @entity957 .

title: The @entity20319 399Gln polymorphism and the frequency of @entity876 mutations in Taiwanese XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['male oral squamous cell carcinomas', 'OSCCs']

entities_list: @entity20322 :: ('p|SUB|R|399|Q', 'ProteinMutation') :: ['Arg399Gln']

entities_list: @entity535 :: ('CHEBI:33704', 'Chemical') :: ['amino acid']

entities_list: @entity72539 :: ('p|SUB|THE|399|Q', 'ProteinMutation') :: ['The 399Gln']

answer: @entity957 :: (MESH:D002294,Disease) :: ['oral squamous cell carcinomas']


abstract: DNA repair gene polymorphisms have been implicated as susceptibility factors in @entity5 development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. @entity72539 polymorphism in the DNA repair gene @entity20319 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of @entity5 development. Two hundred thirty-seven @entity957 ( @entity957 ) were included in a study to investigate the role of the @entity20319 194Trp, 280His, and 399Gln polymorphisms on @entity876 gene mutation. PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the conserved regions of the @entity876 gene (exons 5-9). The @entity20319 genotype was determined by PCR-RFLP. Nineteen (8.02%) of the 237 @entity957 had a @entity7647 / @entity7647 genotype. One hundred six (43.88%) of the 237 @entity957 showed @entity876 gene mutations at exons 5-9. The OSCC @entity1 with a @entity7647 / @entity7647 genotype exhibited a significantly higher frequency of @entity876 mutation than those with an @entity534 / @entity7647 and an Arg/Arg genotype. After adjustment for age, cigarette smoking, areca quid chewing, and @entity167 drinking, the @entity7647 / @entity7647 genotype still showed an independent association with the frequency of @entity876 mutation (odd ratio, 4.50; 95% confidence interval, 1.52-13.36). The findings support the hypothesis that @entity20319 @entity20322 @entity535 change may alter the phenotype of the @entity20319 protein, resulting in a DNA repair deficiency. This study also suggests an important role for the @entity20319 399Gln polymorphism in @entity876 gene mutation in Taiwanese @entity957 .

title: The @entity20319 399Gln polymorphism and the frequency of XXXX mutations in Taiwanese @entity957 .

answer: @entity876 :: (7157,Gene) :: ['p53']


abstract: DNA repair gene polymorphisms have been implicated as susceptibility factors in @entity5 development. It is possible that DNA repair polymorphisms may also influence the risk of gene mutation. @entity72539 polymorphism in the DNA repair gene @entity20319 has been indicated to have a contributive role in DNA adduct formation, sister chromatid exchange, and an increased risk of @entity5 development. Two hundred thirty-seven @entity957 ( @entity957 ) were included in a study to investigate the role of the @entity20319 194Trp, 280His, and 399Gln polymorphisms on @entity876 gene mutation. PCR-single-strand conformation polymorphism and DNA sequencing were used to analyze the conserved regions of the @entity876 gene (exons 5-9). The @entity20319 genotype was determined by PCR-RFLP. Nineteen (8.02%) of the 237 @entity957 had a @entity7647 / @entity7647 genotype. One hundred six (43.88%) of the 237 @entity957 showed @entity876 gene mutations at exons 5-9. The OSCC @entity1 with a @entity7647 / @entity7647 genotype exhibited a significantly higher frequency of @entity876 mutation than those with an @entity534 / @entity7647 and an Arg/Arg genotype. After adjustment for age, cigarette smoking, areca quid chewing, and @entity167 drinking, the @entity7647 / @entity7647 genotype still showed an independent association with the frequency of @entity876 mutation (odd ratio, 4.50; 95% confidence interval, 1.52-13.36). The findings support the hypothesis that @entity20319 @entity20322 @entity535 change may alter the phenotype of the @entity20319 protein, resulting in a DNA repair deficiency. This study also suggests an important role for the @entity20319 399Gln polymorphism in @entity876 gene mutation in Taiwanese @entity957 .

title: The XXXX 399Gln polymorphism and the frequency of @entity876 mutations in Taiwanese @entity957 .

answer: @entity20319 :: (7515,Gene) :: ['XRCC1']


abstract: OBJECTIVE: To present an institutional experience with stent placement in the arterial duct combined with bilateral banding of the pulmonary artery branches as a basis for various surgical strategies in newborns with hypoplastic left @entity299 . DESIGN: Observational study. SETTING: Paediatric heart centre in a university hospital. @entity1 : 20 newborns with various forms of left @entity299 and duct dependent systemic blood flow. INTERVENTIONS: @entity1 underwent percutaneous ductal stenting and surgical bilateral pulmonary artery banding. @entity384 was performed as required, in one premature baby by the transhepatic approach. MAIN OUTCOME MEASURES: Survival; numbers of and reasons for palliative and corrective cardiac surgery. RESULTS: One @entity1 died immediately after percutaneous ductal stenting. One @entity1 died in connection with the surgical approach of bilateral pulmonary banding. Stent and ductal patency were achieved for up to 331 days. Two @entity1 underwent heart transplantation and two @entity1 died on the waiting list. Ten @entity1 had a palliative one stage procedure with reconstruction of the aortic arch and bidirectional cavopulmonary connection at the age of 3.5-6 months. There was one death. One @entity1 is still awaiting this approach. Two @entity1 received biventricular repair. In one, biventricular repair will soon be provided. CONCLUSIONS: Stenting the arterial duct combined with bilateral pulmonary artery banding in newborns with @entity1699 or multiple left @entity299 allows a broad variation of surgical strategies depending on morphological findings, postnatal clinical conditions, and potential ventricular growth.

title: Stenting of the ductus arteriosus and banding of the pulmonary arteries: basis for various surgical strategies in newborns with multiple left XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['Atrial septotomy by balloon dilatation']

entities_list: @entity1699 :: ('MESH:D018636', 'Disease') :: ['hypoplastic left heart']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart obstructive lesions']

answer: @entity299 :: (MESH:D006331,Disease) :: ['heart obstructive lesions']


abstract: This study was performed to investigate whether measurement of @entity8262 ( @entity6708 ), a marker for @entity842 production, before and after allogeneic bone marrow transplantation (BMT) with @entity348 ( @entity348 ) conditioning was of prognostic value. @entity6708 levels were monitored in 23 consecutive @entity1 who received @entity348 as conditioning for BMT, and were compared with the outcome. @entity6708 became positive during the aplastic phase after BMT in 12 @entity1 . In nine of these 12 @entity1 , @entity6708 level decreased during the recovery phase. Eight of the nine @entity1 survived, one dying after relapse. In three other @entity1 , the @entity6708 level continued to increase even during the recovery phase and they died of severe complications. @entity6708 became positive on day 0 of BMT and during the leukocyte recovery phase after BMT in two and seven of the 23 @entity1 , respectively. Subsequently, all @entity1 died of severe complications. The two @entity1 who were negative for @entity6708 both before and after BMT survived without complications. These results suggest that monitoring @entity6708 from early after BMT may be useful for predicting outcome and that it may be a useful prognostic marker.

title: Prognostic value of XXXX in @entity1 undergoing allogeneic bone marrow transplantation after conditioning with @entity348 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8262 :: ('MESH:D006152', 'Chemical') :: ['cyclic GMP']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['TBI', 'total body irradiation']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

answer: @entity8262 :: (MESH:D006152,Chemical) :: ['cyclic GMP']


abstract: This study was performed to investigate whether measurement of @entity8262 ( @entity6708 ), a marker for @entity842 production, before and after allogeneic bone marrow transplantation (BMT) with @entity348 ( @entity348 ) conditioning was of prognostic value. @entity6708 levels were monitored in 23 consecutive @entity1 who received @entity348 as conditioning for BMT, and were compared with the outcome. @entity6708 became positive during the aplastic phase after BMT in 12 @entity1 . In nine of these 12 @entity1 , @entity6708 level decreased during the recovery phase. Eight of the nine @entity1 survived, one dying after relapse. In three other @entity1 , the @entity6708 level continued to increase even during the recovery phase and they died of severe complications. @entity6708 became positive on day 0 of BMT and during the leukocyte recovery phase after BMT in two and seven of the 23 @entity1 , respectively. Subsequently, all @entity1 died of severe complications. The two @entity1 who were negative for @entity6708 both before and after BMT survived without complications. These results suggest that monitoring @entity6708 from early after BMT may be useful for predicting outcome and that it may be a useful prognostic marker.

title: Prognostic value of @entity8262 in @entity1 undergoing allogeneic bone marrow transplantation after conditioning with XXXX .

answer: @entity348 :: (MESH:C535338,Disease) :: ['total body irradiation']


abstract: This study was performed to investigate whether measurement of @entity8262 ( @entity6708 ), a marker for @entity842 production, before and after allogeneic bone marrow transplantation (BMT) with @entity348 ( @entity348 ) conditioning was of prognostic value. @entity6708 levels were monitored in 23 consecutive @entity1 who received @entity348 as conditioning for BMT, and were compared with the outcome. @entity6708 became positive during the aplastic phase after BMT in 12 @entity1 . In nine of these 12 @entity1 , @entity6708 level decreased during the recovery phase. Eight of the nine @entity1 survived, one dying after relapse. In three other @entity1 , the @entity6708 level continued to increase even during the recovery phase and they died of severe complications. @entity6708 became positive on day 0 of BMT and during the leukocyte recovery phase after BMT in two and seven of the 23 @entity1 , respectively. Subsequently, all @entity1 died of severe complications. The two @entity1 who were negative for @entity6708 both before and after BMT survived without complications. These results suggest that monitoring @entity6708 from early after BMT may be useful for predicting outcome and that it may be a useful prognostic marker.

title: Prognostic value of @entity8262 in XXXX undergoing allogeneic bone marrow transplantation after conditioning with @entity348 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: Vulvar and @entity5 are @entity395 with an incidence rate that increases with age. At present, epidemiological data are rather scarce. This review article provides an epidemiologic overview of these diseases, focussing on recent German data. METHODS: This review article summarizes the information currently available in order to offer an epidemiologic overview. RESULTS: The statistic incidence of @entity189 has been calculated between 2 and 7 cases per 100,000 @entity1 , and that of @entity189 0.6-1.0 cases per 100,000 @entity1 . These incidence rates, especially concerning @entity2735 , have increased heavily since the 1970s. The mean age of @entity5 affection is 72 years, and 74 years for @entity189 . In the case of @entity1 below the age of 50, @entity5 tends to be HPV-associated which implies a coincidence of about 20% for cervical and @entity5 . Various pathological mechanisms are the cause for @entity1 above the age of 50. CONCLUSIONS: Due to a change in sexual behavior and an increased rate of @entity281 among younger @entity1 , increased incidence of both diseases has to be expected. The age-standardized mortality rate of @entity189 in Europe is stated at 0.7/100,000 @entity1 , and that of @entity189 at 0.4/100.000 @entity1 . To what extent the HPV-vaccination affects incidence and mortality rates is continually being observed.

title: XXXX in Germany.

entities_list: @entity2735 :: ('MESH:D002278', 'Disease') :: ['intraepithelial neoplasm']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['vaginal cancers', 'vulvar cancer', 'cancer', 'anal cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['vulvar carcinoma', 'vaginal carcinoma']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['HPV infection']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare diseases']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Epidemiology of vulvar and vaginal cancer']


abstract: AIM: @entity177 ( @entity177 ) is the most common cause of unsuccessful pregnancy after assisted reproductive techniques. The @entity5 protein @entity876 ( @entity876 ) codon 72 polymorphism (G-C transversion) has been explored in susceptibility to @entity177 , but inconclusive results have been reported. The aim of this article is to estimate the associations between the @entity876 codon 72 polymorphism and the risk of @entity177 . MATERIALS AND METHODS: A comprehensive search for relevant articles was conducted. The odds ratios (ORs) and 95% confidence intervals (CIs) for CC + GC versus GG, CC versus GC + GG, CC versus GG, GC versus GG genotypes, and C versus G allele, were estimated. Publication bias was explored. Statistical analyses were performed using RevMan 5.2 and Stata 11.0 software. RESULTS: A total of five case-control studies in five articles with 417 @entity177 cases and 325 controls were included. An overall random effect OR of 1.20 (95% CI, 0.66-2.19; P = 0.55) in the dominant model (CC + GC vs GG) was found. The results suggested that a lack of increased or decreased risks were found in individuals who carried the CC homozygote and heterozygote GC, in comparison with the homozygote GG. However, in subgroup analysis by ethnicity, a significantly increased risk was observed among Latin Americans in the dominant model (OR, 1.56; 95% CI, 1.04-2.33; P = 0.03). CONCLUSIONS: This meta-analysis shows that the @entity876 codon 72 polymorphism is not associated with @entity177 risk in the overall population; however, associations were found in the Latin American population.

title: Associations between the codon 72 polymorphism of the XXXX gene and the risk of recurrent implantation failure.

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['RIF', 'Recurrent implantation failure']

answer: @entity876 :: (7157,Gene) :: ['TP53']


abstract: STUDY DESIGN: Systematic literature review OBJECTIVE.: 1) To identify @entity1 reported and clinician based outcome measures most frequently used to evaluate the function and health of spine @entity130 @entity1 , 2) to identify and quantify the concepts of these measures using the ICF as reference, and 3) to describe their clinimetric properties. SUMMARY OF BACKGROUND DATA: There is a real need for a disease specific outcome instrument to measure the effect size of various treatment options in a variety of traumatic spinal column injuries. METHODS: A systematic literature search was conducted in several databases. From the included studies, outcome measures were extracted. The items and underlying concepts of the identified outcome measures were specified and linked to the ICF categories.Finally, as far as available in literature, the clinimetric properties of the obtained measures were analyzed. RESULTS: Out of 5117 screened references, 245 were included, and 17 different frequently used outcome measures were identified.Meaningful concepts of the items and response options of the retrieved outcome measures were linked to a total of 105 different ICF categories, aggregated to 57 first- or second-level categories. The categories were linked to the components activities and participation (n=31), body functions (n=17), environmental factors (n=8), and body structures (n=1).Overall, there is only limited evidence on the measurement properties, except for some disease specific questionnaires, such as ODI, RMDQ, @entity3040 , and CSOQ. CONCLUSIONS: The current systematic literature review revealed great diversity in the use and content of outcome measures to evaluate the functioning and health of spine @entity130 @entity1 , with 17 different outcome measures linked to 57 unique ICF categories.This study creates an evidence base for a consensus meeting during which a core set of ICF categories for outcome measurement in spine @entity130 will be decided. LEVEL OF EVIDENCE: 2.

title: Towards the Development of a Universal Outcome Instrument for Spine @entity130 - A Systematic Review and Content Comparison of Outcome Measures used in Spine XXXX Research Using the ICF as Reference.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity130 :: (MESH:D014947,Disease) :: ['Trauma']


abstract: STUDY DESIGN: Systematic literature review OBJECTIVE.: 1) To identify @entity1 reported and clinician based outcome measures most frequently used to evaluate the function and health of spine @entity130 @entity1 , 2) to identify and quantify the concepts of these measures using the ICF as reference, and 3) to describe their clinimetric properties. SUMMARY OF BACKGROUND DATA: There is a real need for a disease specific outcome instrument to measure the effect size of various treatment options in a variety of traumatic spinal column injuries. METHODS: A systematic literature search was conducted in several databases. From the included studies, outcome measures were extracted. The items and underlying concepts of the identified outcome measures were specified and linked to the ICF categories.Finally, as far as available in literature, the clinimetric properties of the obtained measures were analyzed. RESULTS: Out of 5117 screened references, 245 were included, and 17 different frequently used outcome measures were identified.Meaningful concepts of the items and response options of the retrieved outcome measures were linked to a total of 105 different ICF categories, aggregated to 57 first- or second-level categories. The categories were linked to the components activities and participation (n=31), body functions (n=17), environmental factors (n=8), and body structures (n=1).Overall, there is only limited evidence on the measurement properties, except for some disease specific questionnaires, such as ODI, RMDQ, @entity3040 , and CSOQ. CONCLUSIONS: The current systematic literature review revealed great diversity in the use and content of outcome measures to evaluate the functioning and health of spine @entity130 @entity1 , with 17 different outcome measures linked to 57 unique ICF categories.This study creates an evidence base for a consensus meeting during which a core set of ICF categories for outcome measurement in spine @entity130 will be decided. LEVEL OF EVIDENCE: 2.

title: Towards the Development of a Universal Outcome Instrument for Spine XXXX - A Systematic Review and Content Comparison of Outcome Measures used in Spine @entity130 Research Using the ICF as Reference.

answer: @entity130 :: (MESH:D014947,Disease) :: ['Trauma']


abstract: STUDY DESIGN: A consecutive retrospective cohort study from 2008 to 2013 at a single tertiary-care institution was conducted. OBJECTIVE: Characterize recovery from @entity51 after surgical for @entity4034 , and identify incidence of postoperative adverse events. SUMMARY OF BACKGROUND DATA: A minority of @entity1 with @entity4034 require surgery. While prior studies have characterized outcomes after medical management, the morbidity after surgery is poorly defined. METHODS: The primary outcome was change from baseline in a Modified McCormick Scale (MMS, 1-5 scale), while secondary outcomes included reoperation and change in self-reported @entity158 Visual Analog Scale (VAS, 0-10 scale).MMS and VAS were collected throughout the postoperative course as surrogates for neurologic function and degree of @entity158 . Intraoperative, short-term postoperative (<30 days), and long-term neurologic complications were recorded. New-onset @entity51 in the postoperative period were considered neurologic complications. RESULTS: Fifty @entity1 were included; a majority (52%) presented with a @entity51 . The median length of follow-up was 18 months. A statistically significant improvement in MMS was observed by 12 months postoperatively, while an improvement in VAS was observed by 3 months. The mean improvement in MMS at last follow-up was 0.35, while the mean improvement in VAS was 3.40. One quarter of @entity1 required reoperation. At 24 months postoperatively, 10% died, 26% underwent reoperation, 42% experienced a @entity16 , and 60% experienced at least one of these three adverse events. CONCLUSIONS: This is the first study to investigate neurologic complications, reoperation, and @entity158 in a longitudinal manner following surgery for VO. We observed statistically significant improvements in MMS and VAS in the postoperative period. Despite these improvements, the 24-month incidence of overall adverse events was 60%. @entity1 and clinicians should be aware of the clinical improvement but high incidence of adverse events following surgical management of VO. LEVEL OF EVIDENCE: 4.

title: Neurologic Complications, Reoperation, and Clinical Outcomes following Surgery for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['vertebral osteomyelitis']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic complication']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficit', 'pain and neurologic deficit', 'neurologic deficits']

answer: @entity4034 :: (MESH:D010019,Disease) :: ['Vertebral Osteomyelitis']


abstract: Five ruminally cannulated lactating Holstein @entity291 , fitted with permanent indwelling catheters in the mesenteric vein, hepatic vein, portal vein, and an artery were used to study intestinal absorption and net recycling of inorganic @entity1391 (P(i)) to the gastrointestinal tract. Treatments were low P (LP; 2.4 g of P/kg of @entity3918 ) and @entity2198 ( @entity2198 ; 3.4 g of P/kg of @entity3918 ). The dietary total P (tP) concentrations were obtained by replacing 0.50% @entity4959 in the LP diet with 0.50% @entity58273 in the @entity2198 diet. Diets were fed for 14 d and @entity291 were sampled on d 14 in each period. @entity291 were fed restrictively, resulting in equal dry matter intakes as well as milk, fat, and protein yields between treatments. Net P(i) recycling (primarily salivary) was estimated as the difference between net portal plasma flux (net absorption of P(i)) and apparently digested tP (feed - fecal tP difference). @entity3151 intake, apparently digested tP, and fecal tP excretion decreased with LP. An effect of decreased tP intake on net portal plasma flux of P(i) could not be detected. However, despite numerically minute net fluxes across the liver, the net splanchnic flux of P(i) was less in LP compared with that in @entity2198 . Though arterial plasma P(i) concentration decreased, net P(i) recycling was not decreased when tP intake was decreased, and recycling of P(i) was maintained at the expense of deposition of P(i) in bones. Data are not consistent with salivary P(i) secretion being the primary regulator of P(i) homeostasis at low tP intakes. On the contrary, maintaining salivary P(i) recycling at low tP intakes indicates that rumen function was prioritized at the expense of bone P reserves.

title: Effect of decreasing dietary @entity3151 supply on net recycling of inorganic XXXX in lactating dairy @entity291 .

entities_list: @entity58273 :: ('MESH:C485838', 'Chemical') :: ['monocalcium phosphate']

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['Phosphorus']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity4959 :: ('MESH:D002119', 'Chemical') :: ['calcium carbonate']

answer: @entity1391 :: (CHEBI:26020,Chemical) :: ['phosphate']


abstract: Five ruminally cannulated lactating Holstein @entity291 , fitted with permanent indwelling catheters in the mesenteric vein, hepatic vein, portal vein, and an artery were used to study intestinal absorption and net recycling of inorganic @entity1391 (P(i)) to the gastrointestinal tract. Treatments were low P (LP; 2.4 g of P/kg of @entity3918 ) and @entity2198 ( @entity2198 ; 3.4 g of P/kg of @entity3918 ). The dietary total P (tP) concentrations were obtained by replacing 0.50% @entity4959 in the LP diet with 0.50% @entity58273 in the @entity2198 diet. Diets were fed for 14 d and @entity291 were sampled on d 14 in each period. @entity291 were fed restrictively, resulting in equal dry matter intakes as well as milk, fat, and protein yields between treatments. Net P(i) recycling (primarily salivary) was estimated as the difference between net portal plasma flux (net absorption of P(i)) and apparently digested tP (feed - fecal tP difference). @entity3151 intake, apparently digested tP, and fecal tP excretion decreased with LP. An effect of decreased tP intake on net portal plasma flux of P(i) could not be detected. However, despite numerically minute net fluxes across the liver, the net splanchnic flux of P(i) was less in LP compared with that in @entity2198 . Though arterial plasma P(i) concentration decreased, net P(i) recycling was not decreased when tP intake was decreased, and recycling of P(i) was maintained at the expense of deposition of P(i) in bones. Data are not consistent with salivary P(i) secretion being the primary regulator of P(i) homeostasis at low tP intakes. On the contrary, maintaining salivary P(i) recycling at low tP intakes indicates that rumen function was prioritized at the expense of bone P reserves.

title: Effect of decreasing dietary XXXX supply on net recycling of inorganic @entity1391 in lactating dairy @entity291 .

answer: @entity3151 :: (MESH:D010758,Chemical) :: ['phosphorus']


abstract: Five ruminally cannulated lactating Holstein @entity291 , fitted with permanent indwelling catheters in the mesenteric vein, hepatic vein, portal vein, and an artery were used to study intestinal absorption and net recycling of inorganic @entity1391 (P(i)) to the gastrointestinal tract. Treatments were low P (LP; 2.4 g of P/kg of @entity3918 ) and @entity2198 ( @entity2198 ; 3.4 g of P/kg of @entity3918 ). The dietary total P (tP) concentrations were obtained by replacing 0.50% @entity4959 in the LP diet with 0.50% @entity58273 in the @entity2198 diet. Diets were fed for 14 d and @entity291 were sampled on d 14 in each period. @entity291 were fed restrictively, resulting in equal dry matter intakes as well as milk, fat, and protein yields between treatments. Net P(i) recycling (primarily salivary) was estimated as the difference between net portal plasma flux (net absorption of P(i)) and apparently digested tP (feed - fecal tP difference). @entity3151 intake, apparently digested tP, and fecal tP excretion decreased with LP. An effect of decreased tP intake on net portal plasma flux of P(i) could not be detected. However, despite numerically minute net fluxes across the liver, the net splanchnic flux of P(i) was less in LP compared with that in @entity2198 . Though arterial plasma P(i) concentration decreased, net P(i) recycling was not decreased when tP intake was decreased, and recycling of P(i) was maintained at the expense of deposition of P(i) in bones. Data are not consistent with salivary P(i) secretion being the primary regulator of P(i) homeostasis at low tP intakes. On the contrary, maintaining salivary P(i) recycling at low tP intakes indicates that rumen function was prioritized at the expense of bone P reserves.

title: Effect of decreasing dietary @entity3151 supply on net recycling of inorganic @entity1391 in lactating dairy XXXX .

answer: @entity291 :: (9913,Species) :: ['cows']


abstract: OBJECTIVE: @entity10 is one of the most common debilitating @entity1118 conditions in either active or retired military personnel with mild @entity131 (MTBI). This study assessed the effect of repetitive transcranial magnetic stimulation (rTMS) in alleviating MTBI-related @entity10 (MTBI-HA). MATERIALS AND METHOD: Veterans with MTBI-HA were randomized to receive either real rTMS (REAL group) at 10 hz for a total of 2000 pulses divided into 20 trains with one-sec inter-train interval or sham rTMS (SHAM group) at the left motor cortex (LMC) with brain magnetic resonance imaging neuronavigation guidance. Pretreatment, posttreatment one-week and four-week @entity10 and neuropsychological assessments were conducted. RESULT: Thirty veterans were screened and twenty four (21 @entity1 and 3 @entity1 with average year-old    SD at 14.3    12.6) subjects' data were analyzed. A two-factor (visit * treatment) repeated measures analysis of variance (RM-ANOVA) indicated a close to significant (p = 0.06) trend of interaction between pretreatment and posttreatment one-week assessment with the intensity of the persistent daily @entity10 decreasing from 5.7    1.9 to 2.2    2.7 and 4.6    1.3 to 3.5    2.0 for the REAL and SHAM groups, respectively. Subsequent analyses indicated REAL group demonstrated a significantly (p = 0.041) higher % of reduction in persistent @entity10 intensity than the SHAM group (56.3    48.2% vs.15.4    43.6%) at the posttreatment one-week assessment and the trend continued to the four-week assessment. Overall, a significantly (p = 0.035) higher percentage of the subjects in the REAL group (58.3%) demonstrated at least a 50% @entity10 intensity reduction at posttreatment one-week assessment compared with the SHAM group (16.6%). The overall composite score of functionally debilitating @entity10 exacerbation is significantly (p = 0.017) reduced in REAL group at the posttreatment four-week assessment in comparison with the SHAM group. No major sustained change in neuropsychological assessments was noted. CONCLUSION: The studied rTMS protocol appears to be a clinically feasible and effective treatment option in managing MTBI-HA.

title: Repetitive Transcranial Magnetic Stimulation in Managing Mild XXXX .

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'Headache']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury-Related Headaches']


abstract: BACKGROUND: We investigated whether @entity3446 -based immunosuppression improves outcomes in liver transplantation (LTx) candidates with @entity157 ( @entity157 ). METHODS: In a prospective-randomized open-label international trial, 525 LTx recipients with @entity157 initially receiving @entity1 target of @entity3446 inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation into a group on @entity1 target of @entity3446 inhibitor-free immunosuppression (group A: 264 @entity1 ) or a group incorporating @entity3446 (group B: 261). The primary endpoint was @entity1349 ( @entity1349 ); intention-to-treat (ITT) analysis was conducted after 8 years. @entity1349 ( @entity1349 ) was a secondary endpoint. RESULTS: Recurrence-free survival was 64.5% in group A and 70.2% in group B at study end, this difference was not significant (P = 0.28; hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62; 1.15). In a planned analysis of @entity1349 rates at yearly intervals, group B showed better outcomes 3 years after transplantation (HR, 0.7; 95% CI, 0.48-1.00). Similarly, @entity1349 (P = 0.21; HR, 0.81; 95% CI, 0.58-1.13) was not statistically better in group B at study end, but yearly analyses showed improvement out to 5 years (HR, 0.7; 95% CI, 0.49-1.00). Interestingly, subgroup (Milan Criteria-based) analyses revealed that low-risk, rather than high-risk, @entity1 benefited most from @entity3446 ; furthermore, younger recipients (age  <=60) also benefited, as well @entity3446 monotherapy @entity1 . Serious adverse event numbers were alike in groups A (860) and B (874). CONCLUSIONS: @entity3446 in LTx recipients with @entity157 does not improve long-term @entity1349 beyond 5 years. However, a @entity1349 and @entity1349 benefit is evident in the first 3 to 5 years, especially in low-risk @entity1 . This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with @entity157 .

title: XXXX Use in Liver Transplant Recipients With @entity157 : A Randomized, Multicenter, Open-Label Phase 3 Trial.

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['sirolimus', 'rapamycin', 'Sirolimus']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian', 'patients']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'Overall survival', 'recurrence-free survival']

answer: @entity3446 :: (MESH:D020123,Chemical) :: ['Sirolimus']


abstract: BACKGROUND: We investigated whether @entity3446 -based immunosuppression improves outcomes in liver transplantation (LTx) candidates with @entity157 ( @entity157 ). METHODS: In a prospective-randomized open-label international trial, 525 LTx recipients with @entity157 initially receiving @entity1 target of @entity3446 inhibitor-free immunosuppression were randomized 4 to 6 weeks after transplantation into a group on @entity1 target of @entity3446 inhibitor-free immunosuppression (group A: 264 @entity1 ) or a group incorporating @entity3446 (group B: 261). The primary endpoint was @entity1349 ( @entity1349 ); intention-to-treat (ITT) analysis was conducted after 8 years. @entity1349 ( @entity1349 ) was a secondary endpoint. RESULTS: Recurrence-free survival was 64.5% in group A and 70.2% in group B at study end, this difference was not significant (P = 0.28; hazard ratio [HR], 0.84; 95% confidence interval [95% CI], 0.62; 1.15). In a planned analysis of @entity1349 rates at yearly intervals, group B showed better outcomes 3 years after transplantation (HR, 0.7; 95% CI, 0.48-1.00). Similarly, @entity1349 (P = 0.21; HR, 0.81; 95% CI, 0.58-1.13) was not statistically better in group B at study end, but yearly analyses showed improvement out to 5 years (HR, 0.7; 95% CI, 0.49-1.00). Interestingly, subgroup (Milan Criteria-based) analyses revealed that low-risk, rather than high-risk, @entity1 benefited most from @entity3446 ; furthermore, younger recipients (age  <=60) also benefited, as well @entity3446 monotherapy @entity1 . Serious adverse event numbers were alike in groups A (860) and B (874). CONCLUSIONS: @entity3446 in LTx recipients with @entity157 does not improve long-term @entity1349 beyond 5 years. However, a @entity1349 and @entity1349 benefit is evident in the first 3 to 5 years, especially in low-risk @entity1 . This trial provides the first high-level evidence base for selecting immunosuppression in LTx recipients with @entity157 .

title: @entity3446 Use in Liver Transplant Recipients With XXXX : A Randomized, Multicenter, Open-Label Phase 3 Trial.

answer: @entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']


abstract: OBJECTIVE: To report our experience in the assessment of @entity130 with contrast-coded sonography and a second-generation contrast medium. METHODS: From January to May 2002, 120 @entity1 were studied with sonography for suspected @entity130 . Twenty-five were selected for further imaging because of sonographic findings positive for @entity130 , findings positive for peritoneal fluid only, indeterminate findings, and negative findings with high clinical or laboratory suspicion. These @entity1 underwent contrast-enhanced harmonic sonography and contrast-enhanced helical computed tomography. RESULTS: Among the 25 @entity1 studied, 6 had no spleen trauma at initial and follow-up evaluation. One @entity1 had a hypoperfused spleen without parenchymal damage, and 18 had @entity130 ; these 19 @entity1 were considered positive. @entity18767 was identified by sonography, contrast-enhanced sonography, and contrast-enhanced computed tomography in 74% of the 19 positive cases. @entity4461 were recognized in 58% of the cases by computed tomography and in 42% by baseline and enhanced sonography. @entity1188 were found in 11% of cases by contrast-enhanced sonography and computed tomography; none was found by unenhanced sonography. Parenchymal traumatic lesions were identified in 12 of 18 @entity1 with @entity130 by unenhanced sonography, in 17 cases by contrast-enhanced sonography, and in all 18 cases by contrast-enhanced computed tomography. A minimal @entity75 was found in the single @entity1 with a false-negative contrast-enhanced sonographic finding. Contrast-enhanced sonography correlated appreciably better than unenhanced sonography in detecting injuries and in estimating their extent. Findings undetectable on unenhanced sonography were also noted: splenic hypoperfusion in 11% of positive cases on both contrast-enhanced sonography and contrast-enhanced computed tomography, contrast medium pooling in 21% of cases on both contrast-enhanced sonography and computed tomography, and contrast extravasation in 11% of cases on computed tomography and 5% on contrast-enhanced sonography. CONCLUSIONS: Contrast-enhanced sonography is a promising tool in the assessment of @entity130 . In institutions where sonography is used as the initial procedure, this technique may increase its effectiveness.

title: XXXX : evaluation with contrast-specific sonography and a second-generation contrast medium: preliminary experience.

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['splenic lesion']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['Splenic infarctions']

entities_list: @entity4461 :: ('MESH:D020141', 'Disease') :: ['Perisplenic clots']

entities_list: @entity18767 :: ('MESH:D006465', 'Disease') :: ['Hemoperitoneum']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['splenic injury', 'splenic trauma', 'splenic injuries']

answer: @entity130 :: (MESH:D014947,Disease) :: ['Splenic trauma']


abstract: BACKGROUND: @entity4013 is a very common @entity272 with a broad clinical spectrum. Biopsies are often used to confirm the diagnosis, especially when the clinical presentation is unusual. Not uncommonly organisms are hard to find even with Periodic acid-Schiff stains. Polymerase chain reaction (PCR) for dermatophytes can be used in such cases. OBJECTIVES: To test a new PCR-assay allowing species identification of dermatophytes on @entity982 -embedded biopsies; to reassess histopathological criteria for diagnosis of @entity4013 . METHODS: 121 biopsies of 92 @entity1 with clinical suspicion of @entity4013 were included. In 42 samples the clinical diagnosis had been confirmed histopathologically, in 79 no fungal elements had been identified. Polymerase chain reactions (PCR) targeting the ITS 2 region of dermatophytes were performed on the biopsies with subsequent sequencing. Sections were reassessed for the presence/absence of hyphae/spores, pattern and composition of infiltrate, epidermal/follicular changes. @entity1 charts were reviewed for clinical data. RESULTS: The new ITS2 PCR assay detected 94.3% of the dermatophyte infections (compared with 79.2% identified by microscopy). @entity12734 was the dominant species (88.7%), other species identified were @entity12735 (1.9%), @entity14476 (3.8%), @entity15528 (1.9%), T.interdigitale (3.8%). @entity14235 with T.interdigitale and manifestations with prominent spongiosis were not diagnosed histologically. Intracorneal neutrophils which have been emphasized as a histopathological clue to @entity4013 were present in only 46% of PCR-positive samples. CONCLUSIONS: Molecular species identification of dermatophytes via ITS2 PCR can easily be implemented in a routine dermatopathology setting. It is fast, highly specific, and improves the sensitivity of histopathological diagnosis of @entity4013 . This article is protected by copyright. All rights reserved.

title: Species identification of dermatophytes in XXXX -embedded biopsies with a new PCR-assay targeting the ITS 2 region and comparison with histopathological features.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity4013 :: ('MESH:D014005', 'Disease') :: ['dermatophytosis', 'Dermatophytosis', 'tinea']

entities_list: @entity14235 :: ('MESH:D016870', 'Disease') :: ['Especially infections']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin infection']

answer: @entity982 :: (MESH:D010232,Chemical) :: ['paraffin']


abstract: There is limited information about the benefits of pulmonary rehabilitation (PR) in @entity1 with @entity4595 . This study aimed to evaluate the effects of an out- @entity1 PR program in @entity1 with a primary diagnosis of @entity4595 and to compare them with a matched @entity1030 group who completed the same PR program. A retrospective review was conducted of @entity1 with @entity4595 or @entity1030 who completed 6 to 8 weeks of PR at two tertiary institutions. The outcome measures were the 6-minute walk distance (6MWD) and Chronic @entity1576 Questionnaire (CRQ). Ninety-five @entity1 with @entity4595 completed the PR (48 male; FEV(1) 63 [24] % predicted; age 67 [10] years). Significant improvements in 6MWD (mean change 53.4 m, 95% CI 45.0 to 61.7) and CRQ total score (mean change 14.0 units, 95% CI 11.3 to 16.7) were observed immediately following PR. In @entity1 with complete follow-up (n = 37), these improvements remained significantly higher than baseline at 12 months (20.5 m, 95% CI 1.4 to 39.5 for 6MWD; 12.1 points, 95% CI 5.7 to 18.4 for CRQ total score). The time trend and changes in the 6MWD and CRQ scores were not significantly different between the @entity4595 and the @entity1030 groups (all p > 0.05). This study supports the inclusion of @entity1 with @entity4595 in existing PR programs. Further prospective RCTs are warranted to substantiate these findings.

title: Effects of pulmonary rehabilitation in XXXX : A retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity4595 :: ('MESH:D001987', 'Disease') :: ['bronchiectasis']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['Respiratory Disease']

answer: @entity4595 :: (MESH:D001987,Disease) :: ['bronchiectasis']


abstract: OBJECTIVE: To compare the 3-year results of 2 endoscopic surgical approaches in the management of @entity1412 . DESIGN: Retrospective medical record review. SETTING: Private or institutional practice. @entity1 : A total of 127 @entity1 with @entity1412 were operated on by the same surgeon between January 1, 2003, and September 31, 2005. INTERVENTION: The @entity1 underwent radical ethmoidectomy (n = 77) and polypectomy (n = 50). MAIN OUTCOME MEASURES: Outcome measures were global functional score, calculated by summing the scores (0-3) of each symptom ( @entity384 , @entity5254 , @entity4838 , @entity6587 , and @entity158 ); global anatomical score (GAS), calculated by summing the score of polyp development for each nasal cavity; computed tomography score; adherence to corticosteroid therapy; oral corticosteroid consumption; and complication and subsequent operation rate. Efficacy was evaluated by comparing these data preoperatively and postoperatively (at 3 months, 1 year, and 3 years). RESULTS: The global functional score and GAS were significantly improved 3 years after these techniques were performed (global functional score changes from 8.65 to 3.11 for ethmoidectomy and from 8.15 to 4.2 for polypectomy; GAS, from 5.95 to 1.83 for ethmoidectomy and from 6.57 to 3.58 for polypectomy). Congestion, @entity158 , and GAS were improved to a significantly greater extent in the ethmoidectomy group. The subsequent operation rate for symptomatic polyp recurrence was comparable (9.1% vs 8.0%), with fewer local complications in the polypectomy group. CONCLUSION: Polypectomy seems to represent a valuable alternative in the armamentarium of first-hand surgical procedures for treating @entity1412 .

title: Polypectomy compared with ethmoidectomy in the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['congestion']

entities_list: @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea']

entities_list: @entity6587 :: ('MESH:D016535', 'Disease') :: ['hyperreactivity']

entities_list: @entity1412 :: ('MESH:D011125', 'Disease') :: ['nasal polyposis']

answer: @entity1412 :: (MESH:D011125,Disease) :: ['nasal polyposis']


abstract: OBJECTIVES: To correlate the recurrence of temporalis fascia graft perforation and retraction in adults and @entity1 after tympanoplasty for chronic @entity2346 and deep attic retraction pockets with age, pathologic process, @entity3137 , mucociliary transport time, chronic @entity1244 , and lateral attic wall reconstruction. DESIGN: Retrospective study. SETTING: Tertiary referral center. @entity1 : Two hundred seventy-four adult ears and 41 @entity1 ears were operated on for chronic @entity2346 , 50 adult ears were operated on for @entity11818 , and 56 adult ears were operated on for attic retraction pockets. INTERVENTIONS: Underlay tympanoplasty with or without mastoidectomy and lateral attic wall reconstruction for attic retraction pockets. Mucociliary transport time was investigated using @entity8021 testing. MAIN OUTCOME MEASURES: Recurrent perforation, recurrent attic retraction, and temporalis fascia graft retraction were evaluated. RESULTS: Higher incidences of recurrent perforation were found in adults operated on for @entity2346 vs @entity11818 (P = .02) and in @entity1 (P = .004), especially those 9 years and younger (P = .02). A risk factor in adults was chronic @entity1244 (risk ratio, 35.0; 95% confidence interval, 32.1-38.2; P = .004). Temporalis fascia graft retraction correlated with slower mucociliary transport time in adults (P < .001). A lower incidence of recurrent attic retraction was associated with lateral attic wall reconstruction (P < .001). CONCLUSIONS: Recurrent temporalis fascia graft perforation after tympanoplasty for @entity2346 may be related to age and coexisting chronic @entity1244 . Temporalis fascia graft retraction correlates with slower mucociliary transport time in the eustachian tube. Lateral attic wall reconstruction minimizes recurrent attic retraction in adults.

title: Temporalis fascia graft perforation and retraction after tympanoplasty for chronic XXXX and attic retraction pockets: factors associated with recurrence.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'PATIENTS', 'child']

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']

entities_list: @entity2346 :: ('MESH:D010031', 'Disease') :: ['tubotympanic otitis']

entities_list: @entity8021 :: ('MESH:D012439', 'Chemical') :: ['saccharin']

entities_list: @entity11818 :: ('MESH:D018058', 'Disease') :: ['traumatic tympanic membrane rupture']

entities_list: @entity3137 :: ('MESH:D009059', 'Disease') :: ['mucosal lesions']

answer: @entity2346 :: (MESH:D010031,Disease) :: ['tubotympanic otitis']


abstract: The experience of @entity221 can best be viewed as a situation of multiple losses involving the dying @entity1 , family members and friends, and the health care providers engaged in offering services to them. It is a major transition during which the central @entity1 must cope with the personal meanings of the forthcoming @entity204 as well as other losses brought about by the disease process, medical treatments, and the need to provide care for the dying @entity1 . How families adapt to the stresses and changes imposed by the experience of living with dying depends on their previous experiences with @entity204 , their established patterns of communication about serious matters, and their decision-making practices. Some individuals and families are at greater risk than others for developing maladaptive responses and behaviors during and after the experience of @entity221 . Risk factors to be considered in making hypotheses about the potential for maladaptive reactions include the strength of the attachment to the dying @entity1 , uncontrollable and distressing symptoms, and coping limitations associated with age and other factors contributing to increased vulnerability to the demands of continuous change. Working effectively with different kinds of families during the transition of @entity221 can best be accomplished within a conceptual framework built upon knowledge about @entity1 undergoing change. The concept of safe conduct can serve as an overall guide for the creation of nursing services designed to offer personalized care and accessibility of professional help at times of maximum need by the family. Assisting dying @entity1 and their families toward the achievement of their personal goals is fundamental to the idea of safe conduct. The delivery of nursing care in @entity221 requires an orientation to assessment as an ongoing process that makes use of knowledge about disease processes, medical treatments, individual and group adaptations to loss, risk factors suggestive of maladaptive responses, and family dynamics in relation to crisis and change. Although nurses bring expert knowledge about available treatments and resources, the process of assessment and decision-making about what needs to be done can be best accomplished through a process of contracting with the @entity1 and family. These mutual agreements need to be concerned with the establishment of specific goals, plans for achieving them, available resources within the family, division of responsibility, time limits on the achievement of objectives, and mutual evaluation of the process and the outcomes.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Loss and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient', 'person', 'people']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['terminal illness']

answer: @entity221 :: (MESH:D005334,Disease) :: ['terminal illness']


abstract: OBJECTIVE: To test whether a clinically relevant change in knee function is associated with concurrent or prior change in thigh muscle strength. METHODS: 2675 @entity571 Initiative @entity1 (1485 @entity1 /1190 @entity1 ) with measurements of isometric muscle strength at baseline (BL), year 2 (Y2) and 4 (Y4) follow-up were divided into those with greater than @entity922 ( @entity922 ) worsening (>= 6/68 in WOMAC function) during Y2 > Y4, @entity922 improvement, or without relevant change. Changes in isometric muscle strength, concurrent (Y2 > Y4) and preceding (BL > Y2) function change, were compared between groups using ANCOVA. RESULTS: Concurrent loss in extensor muscle strength in @entity1 with worsening knee function during Y2 > Y4 differed significantly (p=0.03) from that in @entity1 without change (-4.6% 95% CI[-6.8, -2.4]) vs. -2.2% 95%CI[-3.0, -1.4]) and so did the concurrent increase in strength in those with functional improvement (+2.2% 95%CI[-0.3, 4.7]; p<0.0001). This increase in strength remained significantly different after adjusting for covariates but was preceded by a greater loss in strength (-7.7% 95%CI[-10.3, -5.0]; p=0.02) during BL > Y2 compared to those without function change during Y2 > Y4 (-4.3% 95%CI[-5.2, -3.4]). The strength decrease during BL > Y2 in those with worsening knee function during Y2 > Y4 (-4.5% 95%CI[-6.9, -2.2]) did not significantly differ (p=0.87) from those without change in function. No differences between changes in flexor muscle strength were observed between groups. CONCLUSION: The findings suggest a positive concurrent longitudinal association between change in extensor muscle strength and worsening/improvement in knee function in KOA. However, a corresponding change in muscle strength was not observed to precede change in function. This article is protected by copyright. All rights reserved.

title: Longitudinal change in thigh muscle strength prior and concurrent to a @entity922 worsening or improvement in knee function - Data from the XXXX Initiative.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['minimal clinically important', 'MCI']

answer: @entity571 :: (MESH:D010003,Disease) :: ['Osteoarthritis']


abstract: OBJECTIVE: To test whether a clinically relevant change in knee function is associated with concurrent or prior change in thigh muscle strength. METHODS: 2675 @entity571 Initiative @entity1 (1485 @entity1 /1190 @entity1 ) with measurements of isometric muscle strength at baseline (BL), year 2 (Y2) and 4 (Y4) follow-up were divided into those with greater than @entity922 ( @entity922 ) worsening (>= 6/68 in WOMAC function) during Y2 > Y4, @entity922 improvement, or without relevant change. Changes in isometric muscle strength, concurrent (Y2 > Y4) and preceding (BL > Y2) function change, were compared between groups using ANCOVA. RESULTS: Concurrent loss in extensor muscle strength in @entity1 with worsening knee function during Y2 > Y4 differed significantly (p=0.03) from that in @entity1 without change (-4.6% 95% CI[-6.8, -2.4]) vs. -2.2% 95%CI[-3.0, -1.4]) and so did the concurrent increase in strength in those with functional improvement (+2.2% 95%CI[-0.3, 4.7]; p<0.0001). This increase in strength remained significantly different after adjusting for covariates but was preceded by a greater loss in strength (-7.7% 95%CI[-10.3, -5.0]; p=0.02) during BL > Y2 compared to those without function change during Y2 > Y4 (-4.3% 95%CI[-5.2, -3.4]). The strength decrease during BL > Y2 in those with worsening knee function during Y2 > Y4 (-4.5% 95%CI[-6.9, -2.2]) did not significantly differ (p=0.87) from those without change in function. No differences between changes in flexor muscle strength were observed between groups. CONCLUSION: The findings suggest a positive concurrent longitudinal association between change in extensor muscle strength and worsening/improvement in knee function in KOA. However, a corresponding change in muscle strength was not observed to precede change in function. This article is protected by copyright. All rights reserved.

title: Longitudinal change in thigh muscle strength prior and concurrent to a XXXX worsening or improvement in knee function - Data from the @entity571 Initiative.

answer: @entity922 :: (MESH:D013568,Disease) :: ['minimal clinically important']