abstract: 20 @entity308 and 16 obsessive compulsive in- @entity1 who took part at a psychoanalytic group psychotherapy were reexamined 2--9 years later. The question was pursued whether there are relations between data of life history and severity of @entity11167 on the one hand and outcome on the other hand. On account of further individual and group psychotherapy after discharge different durations of treatment were reached. Their influence on the outcome was studied. The findings were: 1. Some data concerning education, profession/capacity for work, contact, sexuality/partnership could be related to favorable and unfavorable outcomes. 2. It was possible too, to find relations between items which characterize the severity of @entity11167 and outcome. 3. Longer duration of treatment results in significant better outcomes. 4. A tendency was found, that changes of @entity1314 traits in comparison with symptomatic improvement are more close connected with duration of treatment than with severity of @entity11167 .

title: [Prognostic criteria in institutional group psychotherapy of @entity308 and compulsive neurotic XXXX ].

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Electrophysiologic and isotopic techniques were used to characterize the anion permeabilities of isolated perfused @entity95 proximal tubules (S2 segments). Tubules were differentiated into @entity2865 - and @entity1372 -selective populations by electrophysiologic rather than by anatomic criteria. The tubules were studied under conditions that inhibited active @entity1372 transport. The isotopic @entity2865 permeability coefficient was 5.5 +/- 0.6 X 10(-5) cm/s (n = 19) for @entity2865 -selective tubules and 3.2 +/- 0.6 X 10(-5) cm/s (n = 15) for @entity1372 -selective tubules. The @entity20412 permeability coefficient was 1.1 +/- 0.2 X 10(-5) cm/s (n = 23) and did not vary with @entity1372 or @entity2865 selectivity. The variation of oxyanion permeability ( @entity3157 , @entity20412 , and @entity28056 ) relative to @entity2865 resulted from changes in @entity2865 permeability, per se, rather than any change in the oxyanion permeability. A consistent relation between @entity3157 and @entity20412 permeability permitted the permeability of @entity3157 ion to be estimated at 1.3 X 10(-5) cm/s. The mechanism of ion selectivity appears to be different for the two populations of tubules. @entity2865 -selective tubules appear to hve relatively small pathways that do not contain fixed-charge sites. In contrast, @entity1372 -selective tubules may have permeation pathways that contain fixed negative-charge sites.

title: Anion permeabilities of the isolated perfused XXXX proximal tubule.

entities_list: @entity20412 :: ('CHEBI:61904', 'Chemical') :: ['isethionate']

entities_list: @entity28056 :: ('MESH:D003494', 'Chemical') :: ['cyclamate']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['Chloride', 'chloride']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: BACKGROUNDS/AIMS: Simple @entity96 were easily recognizable with the advanced imaging procedures, such as ultrasound and computed tomography scan. A large cyst or significant symptoms were indications for the treatments. Ablation therapy with @entity3808 agents was effective, but there were several complications including severe @entity158 . With the surgical cyst unroofing method introduced, we compared the cyst unroofing method and ablation therapy. METHODS: Between March 1997 and May 2011, we performed treatments of simple @entity96 in 27 @entity1 . There were 23 @entity1 and 4 @entity1 (age range: 42-84 years; mean age: 64 years). The cyst unroofing was undergone with laparoscopic (n=13) and open technique (n=1). The ablation therapy was performed with @entity1068 (n=13) and @entity1543 (n=1). RESULTS: The usual symptoms of the @entity96 were abdominal mass (n=7), indigestion (n=4), abdominal discomfort (n=3), and the increasing size of the cysts (n=4). The mean diameter of the cysts was 10.9 cm. The cyst unroofing method was performed effectively in 14 @entity1 . One @entity1 had @entity548 during operation, and was converted to the open technique. One @entity1 had a bile leak from the cyst, but it was successfully closed with the laparoscopic technique. Among the 14 cases with the ablation therapy, there were 4 complications: @entity1410 (n=1); cyst leaking during aspiration (n=2); @entity810 (n=1); and death due to @entity1543 intoxication (n=1). CONCLUSIONS: Laparoscopic cyst unroofing was more effective and safer in management than the ablation therapy in simple @entity96 .

title: Managements of simple XXXX : ablation therapy versus cyst unroofing.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver cysts']

entities_list: @entity3808 :: ('MESH:C538213', 'Disease') :: ['sclerotic']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

answer: @entity96 :: (MESH:D008113,Disease) :: ['liver cysts']


abstract: BACKGROUND: Low-grade @entity11 (LGGs) are the second most prevalent type of primary @entity1313 in adults. The prognosis for LGGs can differ according to the clinical-pathological prognostic factors determined during diagnosis and treatment. The purpose of this study was to identify 10-year, disease-free survival (DFS), 10-year @entity1349 ( @entity1349 ), and related clinical-pathological prognostic factors of adult @entity1 with supratentorial, low-grade @entity11 who were treated with or without surgery and radiation therapy. METHODS: The study included 110 @entity1 who were confirmed to have low-grade, @entity11 and who had received surgery and adjuvant radiation therapy or salvage radiotherapy as part of their treatment. These @entity1 were followed by the radiation-oncology ward at Shohada-e-Tajrish Hospital in Tehran, Iran, between 2002 and 2012. The log-rank test (univariate) and the @entity797 proportional hazards model (multivariate) were used to examine the 10-year DFS and @entity1349 and to assess the strengths of various histo-clinical factors relative to 10-year DFS and @entity1349 . RESULTS: The study included 110 @entity1 for whom 10-year DFS and @entity1349 were found to be 23 and 28%, respectively. Favorable prognostic factors in the univariate analysis using the Kaplan-Meier 10-year @entity1349 analysis were the following: age below 40, karnofsky performance status (KPS) more than 70, the presence of @entity3271 , @entity5 size of < 5 cm, and gross-total resection (p=0.02, p=0.01, p=0.03, p=0.01, p=0.02, respectively). Good prognostic factors in multivariate analysis using the @entity797 regression model were as follows: age below 40, the presence of @entity3271 , @entity5 size< 5 cm, and gross total resection in10-year @entity1349 (p=0.01, p=0.03, p=0.00, p=0.02, respectively). CONCLUSIONS: Gross-total resection, @entity5 size < 5 cm, age below 40, and the presence of @entity3271 had better 10-year DFS and @entity1349 rates. We recommend that all @entity1 with @entity5 be referred to neuro-oncology centers that have sufficient experience to achieve the best results of treatment.

title: Overall survival in adult @entity1 with low-grade, XXXX : Ten years' follow up at a single institution.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'LGG tumors']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['supratentorial gliomas', 'gliomas']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

entities_list: @entity3271 :: ('MESH:D009837', 'Disease') :: ['oligodendroglioma']

answer: @entity11 :: (MESH:D005910,Disease) :: ['supratentorial glioma']


abstract: BACKGROUND: Low-grade @entity11 (LGGs) are the second most prevalent type of primary @entity1313 in adults. The prognosis for LGGs can differ according to the clinical-pathological prognostic factors determined during diagnosis and treatment. The purpose of this study was to identify 10-year, disease-free survival (DFS), 10-year @entity1349 ( @entity1349 ), and related clinical-pathological prognostic factors of adult @entity1 with supratentorial, low-grade @entity11 who were treated with or without surgery and radiation therapy. METHODS: The study included 110 @entity1 who were confirmed to have low-grade, @entity11 and who had received surgery and adjuvant radiation therapy or salvage radiotherapy as part of their treatment. These @entity1 were followed by the radiation-oncology ward at Shohada-e-Tajrish Hospital in Tehran, Iran, between 2002 and 2012. The log-rank test (univariate) and the @entity797 proportional hazards model (multivariate) were used to examine the 10-year DFS and @entity1349 and to assess the strengths of various histo-clinical factors relative to 10-year DFS and @entity1349 . RESULTS: The study included 110 @entity1 for whom 10-year DFS and @entity1349 were found to be 23 and 28%, respectively. Favorable prognostic factors in the univariate analysis using the Kaplan-Meier 10-year @entity1349 analysis were the following: age below 40, karnofsky performance status (KPS) more than 70, the presence of @entity3271 , @entity5 size of < 5 cm, and gross-total resection (p=0.02, p=0.01, p=0.03, p=0.01, p=0.02, respectively). Good prognostic factors in multivariate analysis using the @entity797 regression model were as follows: age below 40, the presence of @entity3271 , @entity5 size< 5 cm, and gross total resection in10-year @entity1349 (p=0.01, p=0.03, p=0.00, p=0.02, respectively). CONCLUSIONS: Gross-total resection, @entity5 size < 5 cm, age below 40, and the presence of @entity3271 had better 10-year DFS and @entity1349 rates. We recommend that all @entity1 with @entity5 be referred to neuro-oncology centers that have sufficient experience to achieve the best results of treatment.

title: Overall survival in adult XXXX with low-grade, @entity11 : Ten years' follow up at a single institution.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Temporo-parietal cortex thinning is associated with @entity73 ( @entity73 ) due to @entity195 ( @entity195 ). The increase of the EEG upper/low alpha power ratio has been associated with @entity73 due to @entity195 subjects and to the @entity194 of temporo-parietal brain areas. Moreover, subjects with a higher alpha3/alpha2 frequency power ratio showed lower brain perfusion than in the low alpha3/alpha2 group. The two groups have significantly different hippocampal volumes and correlation with the theta frequency activity. METHODS: 74 adult subjects with @entity73 underwent clinical and neuropsychological evaluation, electroencephalogram (EEG) recording, and high resolution 3D magnetic resonance imaging (MRI). 27 of them underwent EEG recording and perfusion single-photon emission computed tomography (SPECT) evaluation. The alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. The difference in cortical thickness between the groups was estimated. Pearson's r was used to assess the correlation topography between cortical thinning as well as between brain perfusion and @entity2414 . RESULTS: In the higher upper/low alpha group, @entity2414 was more pronounced both in the MRI group and the SPECT @entity73 group. Moreover, it was correlated with greater cortical @entity194 and lower perfusional rate in temporo-parietal cortex. CONCLUSION: High EEG upper/low alpha power ratio was associated with cortical thinning lower perfusion in temporo-parietal. Moreover, @entity194 and lower perfusional rate were both significantly correlated with @entity2414 in @entity73 subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to @entity195 and may be of value in the clinical context.

title: @entity194 and lower regional perfusion of temporo-parietal brain areas are correlated with XXXX and increase of EEG upper alpha power in prodromal @entity195 .

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['MCI', 'mild cognitive impairment']

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory impairment']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'AD dementia', "Alzheimer's disease"]

answer: @entity2414 :: (MESH:D008569,Disease) :: ['impairment in memory performances']


abstract: BACKGROUND: Temporo-parietal cortex thinning is associated with @entity73 ( @entity73 ) due to @entity195 ( @entity195 ). The increase of the EEG upper/low alpha power ratio has been associated with @entity73 due to @entity195 subjects and to the @entity194 of temporo-parietal brain areas. Moreover, subjects with a higher alpha3/alpha2 frequency power ratio showed lower brain perfusion than in the low alpha3/alpha2 group. The two groups have significantly different hippocampal volumes and correlation with the theta frequency activity. METHODS: 74 adult subjects with @entity73 underwent clinical and neuropsychological evaluation, electroencephalogram (EEG) recording, and high resolution 3D magnetic resonance imaging (MRI). 27 of them underwent EEG recording and perfusion single-photon emission computed tomography (SPECT) evaluation. The alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. The difference in cortical thickness between the groups was estimated. Pearson's r was used to assess the correlation topography between cortical thinning as well as between brain perfusion and @entity2414 . RESULTS: In the higher upper/low alpha group, @entity2414 was more pronounced both in the MRI group and the SPECT @entity73 group. Moreover, it was correlated with greater cortical @entity194 and lower perfusional rate in temporo-parietal cortex. CONCLUSION: High EEG upper/low alpha power ratio was associated with cortical thinning lower perfusion in temporo-parietal. Moreover, @entity194 and lower perfusional rate were both significantly correlated with @entity2414 in @entity73 subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to @entity195 and may be of value in the clinical context.

title: XXXX and lower regional perfusion of temporo-parietal brain areas are correlated with @entity2414 and increase of EEG upper alpha power in prodromal @entity195 .

answer: @entity194 :: (MESH:D001284,Disease) :: ['Atrophy']


abstract: BACKGROUND: Temporo-parietal cortex thinning is associated with @entity73 ( @entity73 ) due to @entity195 ( @entity195 ). The increase of the EEG upper/low alpha power ratio has been associated with @entity73 due to @entity195 subjects and to the @entity194 of temporo-parietal brain areas. Moreover, subjects with a higher alpha3/alpha2 frequency power ratio showed lower brain perfusion than in the low alpha3/alpha2 group. The two groups have significantly different hippocampal volumes and correlation with the theta frequency activity. METHODS: 74 adult subjects with @entity73 underwent clinical and neuropsychological evaluation, electroencephalogram (EEG) recording, and high resolution 3D magnetic resonance imaging (MRI). 27 of them underwent EEG recording and perfusion single-photon emission computed tomography (SPECT) evaluation. The alpha3/alpha2 power ratio as well as cortical thickness was computed for each subject. The difference in cortical thickness between the groups was estimated. Pearson's r was used to assess the correlation topography between cortical thinning as well as between brain perfusion and @entity2414 . RESULTS: In the higher upper/low alpha group, @entity2414 was more pronounced both in the MRI group and the SPECT @entity73 group. Moreover, it was correlated with greater cortical @entity194 and lower perfusional rate in temporo-parietal cortex. CONCLUSION: High EEG upper/low alpha power ratio was associated with cortical thinning lower perfusion in temporo-parietal. Moreover, @entity194 and lower perfusional rate were both significantly correlated with @entity2414 in @entity73 subjects. The increase of EEG upper/low alpha frequency power ratio could be useful for identifying individuals at risk for progression to @entity195 and may be of value in the clinical context.

title: @entity194 and lower regional perfusion of temporo-parietal brain areas are correlated with @entity2414 and increase of EEG upper alpha power in prodromal XXXX .

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']


abstract: @entity1 and porcine @entity3993 is caused by the larval stage of the flatworm @entity8785 (Cestoda). Infestation of the @entity1 brain, also known as @entity6583 , is the most common parasite disease of the central nervous system worldwide. Significant advances in the understanding of the disease have been achieved using the @entity21150 @entity19 model. We describe here a successful transfection protocol of @entity21150 cysticerci as the first step to approach a number of currently inaccessible biological questions on @entity3993 . @entity21150 cysticerci ( @entity6475 ) were microinjected with the plasmid pcDNA3.1/NT-GFP-TOPO, encoding the green fluorescent protein (GFP) driven by a cytomegalovirus promoter ( @entity2834 ). Twelve hours after the microinjection, GFP fluorescence gradually developed in patches associated to bud structures in the bladder wall of cysts. Fluorescence reached a peak at 24-48  h and lasted up to 72  h after the microinjection. Immunohistochemical studies on tissue sections of transfected cysts using an anti-GFP antibody, demonstrated co-localization of the antibody and the GFP fluorescence in the tegumentary cytoplasm and subtegumentary cytons. To validate at the mRNA level the expression of GFP, we carried out RT-PCR using two pairs of nested primers. Results showed expression of GFP-mRNA at 24  h post-transfection. Moreover, western blot assays of crude extracts of transfected cysts, carried out using the anti-GFP specific antibody, showed the expected protein band of 27  kDa, demonstrating that the GFP expression started at 24 after plasmid microinjection and was maintained up to 72  h. These findings will facilitate the development of functional genomics approaches applied to this model of @entity3993 .

title: Transient transgenesis of the tapeworm XXXX .

entities_list: @entity6583 :: ('MESH:D020019', 'Disease') :: ['neurocysticercosis']

entities_list: @entity3993 :: ('MESH:D003551', 'Disease') :: ['cysticercosis']

entities_list: @entity6475 :: ('MESH:D013180', 'Disease') :: ['ORF strain']

entities_list: @entity8785 :: ('6204', 'Species') :: ['Taenia solium']

entities_list: @entity21150 :: ('6207', 'Species') :: ['T. crassiceps', 'Taenia crassiceps']

answer: @entity21150 :: (6207,Species) :: ['Taenia crassiceps']


abstract: OBJECTIVE: Purpose of this retrospective study was to evaluate outcomes autogenous bone block grafts obtained from mandible for different indications. The healing of the donor and recipient sites in the postoperative period, morbidity and the resorption of the graft were investigated. @entity1 AND METHODS: Twenty-nine @entity1 grafted with mandibular bone block graft were participated in the present study. Grafting was applied in these @entity1 for three indications; reconstruction of @entity2419 , lateral @entity50 . All operations were performed under local anesthesia and in some cases sedation was used as well. RESULTS: Minimal exposure of the block graft occurred in three @entity2419 @entity1 . Secondary epithelization was achieved in all cleft @entity1 with no symptoms of @entity281 . In one @entity1 @entity281 was seen in donor site 1-week after the operation. The region was curetted and antibiotics administrated again. Two @entity1 showed an @entity281 of recipient site, after 4 weeks the grafts were removed. In all the @entity1 , as the screw head became apparent until 1 thread, amount of the resorption were considered <1.5 mm. CONCLUSION: The usage of mandibular block grafts is a simple and effective treatment modality for reconstruction of different types of @entity133 and it also reduces cost of treatment.

title: The use of autogeneous mandibular bone block grafts for reconstruction of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity133 :: ('MESH:D002282', 'Disease') :: ['alveolar defects']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity2419 :: ('MESH:D002972', 'Disease') :: ['alveolar cleft']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['crest augmentation before dental implantation and sinus floor augmentation']

answer: @entity133 :: (MESH:D002282,Disease) :: ['alveolar defects']


abstract: In the Framingham Study 2325 @entity1 and 2866 @entity1 30 to 62 years old at entry were followed biennially over 22 years for the development of @entity955 in relation to antecedent @entity65 and risk factors. During surveillance, @entity955 developed in 49 @entity1 and 49 @entity1 . The incidence rose sharply with age but did not differ significantly between the sexes. Overall, there was a 2.0 per cent chance that the disorder would develop in two decades. @entity955 usually followed the development of overt @entity65 . Only 18 @entity1 and 12 @entity1 (31 per cent) had @entity955 in the absence of @entity65 . @entity712 and @entity6331 were the most powerful predictive precursors, with relative risks in excess of sixfold. @entity65 was the most common antecedent disease, largely because of its frequency in the general population. Among the risk factors for @entity65 , @entity6 and electrocardiographic evidence of @entity4346 were related to the occurrence of @entity955 . The development of @entity955 was associated with a doubling of overall mortality and of mortality from @entity65 .

title: Epidemiologic features of XXXX : the Framingham study.

entities_list: @entity6331 :: ('MESH:D012214', 'Disease') :: ['rheumatic heart disease']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Cardiac failure']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'Atrial fibrillation', 'chronic atrial fibrillation']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['Hypertensive cardiovascular disease', 'cardiovascular disease']

answer: @entity955 :: (MESH:D001281,Disease) :: ['chronic atrial fibrillation']


abstract: The authors report a case of parasellar @entity2477 having grown to the suprasellar region within 3 year's period and showing acute visual disturbance caused by @entity548 . A 44-year-old @entity1 , who had experienced spontaneous @entity1779 in the left inferior frontal lobe 3 years ago and then obtained good recovery in the post-operative period had suddenly developed @entity227 without other @entity51 . CT scan revealed an irregular @entity66 in the chiasmal region, which had a crown-like high density area over the suprasellar low density. Carotid angiogram showed a suprasellar avascular mass and the left A1 segment showed marked narrowing. Neither @entity5 nor venous pooling was visible in the capillary and venous phase. Surgery disclosed a @entity5 with thin capsular wall, extending from the left cavernous sinus to the suprasellar region, and it was accompanied by @entity548 compressing the left optic nerve. The @entity5 was subtotally removed. High density area on the precontrast scan was confirmed to be @entity548 and the low density area was of organized tissue due to @entity715 . Histological finding was compatible to @entity2477 . Postoperatively visual acuity of the @entity1 was well recovered, but left 3rd and 6th @entity129 followed. The authors discussed the mechanism of acute onset and CT findings of the @entity2477 arising in the chiasmal region with a review of literature.

title: [A case of XXXX with acute visual disturbance (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial nerve palsy']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['decreased visual acuity of the left eye']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['mass lesion']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intratumoral hemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'reddish dark tumor']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity2477 :: ('MESH:D006392', 'Disease') :: ['cavernous hemangioma']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['intracerebral hematoma']

answer: @entity2477 :: (MESH:D006392,Disease) :: ['cavernous hemangioma']


abstract: OBJECTIVES: The aim of the study was to evaluate the effect of an intensified preventive programme in kindergartens. MATERIALS AND METHODS: Two thousand two hundred twenty-eight 2- to 4-year-old @entity1 attending kindergartens in two counties in northern Hesse were randomly allocated to two groups. @entity1 in the test group participated in daily tooth brushing with 500  ppm @entity1388 toothpaste, which was supervised by specially trained dental nurses. @entity1 in the control group received tooth brushing instructions three to four times a year. Caries experience was recorded using WHO criteria. The basic survey was performed from October 2006 to April 2007, with the final examinations between March and July 2009. The statistical evaluation was performed by means of the software package SPSS 17.0. To compare the mean   dmf values of the test and control groups, Mann-Whitney U tests were performed. RESULTS: Two thousand one hundred twelve @entity1 (test group, 1096; control group, 1048) participated in the final examinations. The caries increment of the test group (  dmf-s   =   1.55) was 24  % lower than the increment of the control group (  dmf-s   =   2.02, p   =   0.043). Based on   dmf-t values, the corresponding figures were 0.79 for the @entity5482 for the control group (p   =   0.44). High increment values (  dmf-s >7) were observed in the control group twice as often as in the test group. CONCLUSION: The results show that an intensified preventive programme in kindergartens, based on supervised daily tooth brushing, has a positive effect on the dental health of preschool @entity1 . CLINICAL RELEVANCE: It is sufficient to offer such programmes in socially deprived areas.

title: Prevention in kindergartens with 500  ppm XXXX toothpaste-a randomized clinical trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride']

answer: @entity1388 :: (MESH:D005459,Chemical) :: ['fluoride']


abstract: UNASSIGNED: Since its advent in 1991, endovascular @entity449 repair (EVAR) has become a mainstay of treatment for @entity1028 ( @entity1028 ). Studies such as the @entity439 repair with open repair in @entity1 with @entity1028 (EVAR 1) trial, have demonstrated the effectiveness of EVAR in reducing perioperative mortality. Technological improvements in graft design and delivery account for an increasing utilization of endovascular repair. Newer branch and fenestrated graft designs have allowed for treatment of @entity1 with complex aortic anatomy that previously could not be treated with EVAR. Endovascular repair, while dominant, is unlikely to eliminate the need for open repair or to relegate open surgery for @entity1028 to historical interest only. The unprecedented adoption of EVAR has led to complications and modes of failure that were not seen with open repair. The rate of failure is markedly increased when endografts are used outside of the instructions for use (IFU). The long-term durability of fenestrated and investigational branch devices remains to be established. The demand for an endovascular approach by @entity1 and the willingness of physicians to place endografts outside the anatomic IFU criteria may have resulted in the pendulum swinging too far away from open surgical management. The consequence of reduced open aortic surgeries is a concern for both @entity1 care as well as training for vascular surgery fellows. Vascular surgery training programs will require innovative changes in training to assure that vascular surgery trainees will have the requisite skill and experience required to competently perform open surgical repair on what will undoubtedly be some of the most complex aortic pathology.

title: Management of XXXX : Is Surgery of Historic Interest Only?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysms', 'abdominal aortic aneurysm', 'AAA']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic aneurysm']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['comparison of endovascular aneurysm']

answer: @entity449 :: (MESH:D001014,Disease) :: ['Aortic Aneurysms']


abstract: A case of @entity13871 in a 2(6)/12 years old @entity1 is described. The @entity9160 usually is seen in preschool @entity1 . Clinical symptoms were characterised by @entity1712 of more than 30%, @entity491 , @entity382 , @entity358 , and hypergammaglobulinaemia. There may be myocardial, ocular or central nervous system involvement, and a few affected @entity1 have died. The disease is caused by invasion of the body tissues by @entity5603 or cati larvae, often ingested by contaminated dirt. The developmental cycle and the migration of the Toxocara larvae in the @entity1 host is discussed. Diagnosis can usually be made by clinical and serological investigations. The microprecipitation test on living larvae of @entity5603 is highly specific for the diagnosis. There is no effective specific therapy for @entity13871 , however, treatment with @entity18884 and @entity6566 may be helpful. Primary prevention of @entity9160 can be achieved by reduction of the @entity1 exposure to infected animals and contaminated environments, or by elimination of infections in @entity235 , puppies, and @entity468 .

title: [Toxocariasis in childhood. XXXX (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human', 'boy']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity6566 :: ('MESH:D004049', 'Chemical') :: ['diethylcarbamazine']

entities_list: @entity9160 :: ('MESH:D007816', 'Disease') :: ['visceral larva migrans syndrome']

entities_list: @entity5603 :: ('6265', 'Species') :: ['Toxocara canis']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary infiltrations']

entities_list: @entity382 :: ('MESH:D006529', 'Disease') :: ['hepatomegaly']

entities_list: @entity13871 :: ('MESH:D014120', 'Disease') :: ['toxocariasis']

entities_list: @entity491 :: ('MESH:D007964', 'Disease') :: ['leukocytosis']

entities_list: @entity18884 :: ('MESH:D013827', 'Chemical') :: ['thiabendazole']

answer: @entity9160 :: (MESH:D007816,Disease) :: ['Visceral larva migrans syndrome']


abstract: BACKGROUND: The UK prevalence of @entity1028 ( @entity1028 ) is estimated at 4.9% in over 65-year olds. Progressive and unpredictable enlargement can lead to @entity397 . Endovascular repair of AAAs involves a stent graft system being introduced via the femoral artery and manipulated within the aorta under radiological guidance. Following endograft deployment, a seal is formed at the proximal and distal landing zones to exclude the @entity439 sac from the circulation. With the increasing popularity of endovascular repair there has been an increase in the number of commercially available stent graft designs on the market. This is an update of the review first published in 2013. OBJECTIVES: This review aimed to assess the different stent graft types for endovascular repair of @entity1028 . SEARCH METHODS: The Cochrane Vascular Group @entity325 ( @entity325 ) searched the Specialised Register (last searched February 2015) and the Cochrane Register of Studies (2015, Issue 1). Trial databases were searched by the @entity325 for details of ongoing and unpublished studies. SELECTION CRITERIA: All published and unpublished randomised controlled trials (RCTs) of stent graft types in the repair of AAAs were sought without language restriction and in consultation with the Cochrane Vascular Group @entity325 . DATA COLLECTION AND ANALYSIS: We planned to conduct data collection and analysis in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. MAIN RESULTS: No studies were identified that met the inclusion criteria. It was not possible to review the quality of the evidence in the absence of studies eligible for inclusion in the review. AUTHORS' CONCLUSIONS: Unfortunately, no data exist regarding direct comparisons of the performance of different stent graft types. High quality randomised controlled trials evaluating stent graft types in @entity439 repair are required.

title: Stent graft types for endovascular repair of XXXX .

entities_list: @entity325 :: ('MESH:D060085', 'Disease') :: ['Trials Search Co-ordinator', 'TSC']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm', 'AAA']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['abdominal endovascular aneurysm', 'aneurysm']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysms']


abstract: Importance: Different adjuvant chemotherapy regimens are available for @entity0 . Because conventional meta-analysis does not allow comparing all regimens, we performed a network meta-analysis to identify the most effective adjuvant chemotherapy regimen. Objective: To find the most effective adjuvant therapy regimen for @entity0 . Data Sources: We searched MEDLINE, Embase, and the Cochrane Library for articles published before June 2015; the American Society of Clinical Oncology annual meeting abstracts from January 1983 through December 2014; and the American Association for @entity5 Research annual meeting abstracts from January 1916 through December 2014. Additionally, we manually searched bibliographies for related references. Study Selection: We included randomized clinical trials of adjuvant treatments for @entity0 that compared 2 or more of the following: no adjuvant chemotherapy; sequential @entity5948 - @entity786 and @entity3907 (AC-T); concurrent @entity5948 - @entity786 and @entity3907 (ACT); @entity5948 - @entity786 without @entity3907 (AC); @entity1205 and @entity786 (TC); @entity786 , @entity1499 , and @entity1487 (CMF); and @entity902 -containing regimens. Data Extraction and Synthesis: We followed the PRISMA guidelines. Two investigators independently selected the articles and extracted information. Disagreements were resolved by discussion with another author. Quality was assessed by Cochrane risk-of-bias method. Data were pooled using random-effects models. Main Outcomes and Measures: We used network meta-analysis to test the most effective adjuvant therapy regimen in terms of @entity1349 ( @entity1349 ) by comparing regimens listed in the National @entity5 Network guidelines and @entity902 -containing regimens. Results: We identified 24 trials. The TC and @entity902 -containing regimens had @entity1349 benefit similar to that of sequential AC-T (TC hazard ratio [HR], 0.93; 95% CI, 0.62-1.40; and @entity902 HR, 0.93; 95% CI, 0.66-1.31). @entity1 treated with CMF or AC had significantly worse @entity1349 than those treated with sequential AC-T (CMF HR, 1.56; 95% CI, 1.32-1.85; and AC HR, 1.22; 95% CI, 1.10-1.37). @entity902 -containing regimens tended to be more toxic than sequential AC-T. The @entity137 of TC was similar to or less than that of sequential AC-T. Meta-regression analysis showed that hormone receptor status did not impact the HRs for @entity1349 for any regimen. Conclusions and Relevance: Sequential AC-T is likely to be the most effective adjuvant therapy regimen for @entity0 regardless of hormone receptor status.

title: Effectiveness of an Adjuvant Chemotherapy Regimen for Early-Stage Breast XXXX : A Systematic Review and Network Meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['early-stage breast cancer']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum', 'Platinum']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Comprehensive Cancer', 'Cancer']

entities_list: @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity1205 :: ('MESH:C067311', 'Chemical') :: ['docetaxel']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: OBJECTIVES: Reamer-irrigator-aspirator (RIA) bone graft harvesting @entity1 femurs have resulted in @entity174 . Recommendations/studies on safe RIA diameter are noncomprehensive/inconclusive. Our purpose was to develop an analytical model to predict % reduction in torsional strength after intramedullary oversize reaming (concentric or eccentric) and to test cadaveric femurs with normal-to-osteoporotic bone mineral density to investigate its relationship to femur cross-sectional properties, bone material strength, and torsional strength reduction. METHODS: An eccentric circular cross-sectional model was developed. Twenty matched cadaveric femurs ( @entity19355 ) were tested. Left femur was reamed 1.5 mm larger than isthmic endosteal diameter measured from radiographs. Right (control) and left (reamed) femurs were torsionally loaded to failure. @entity1048 were fit tangent to the thinnest wall on computer tomography cross-sectional image at level of @entity174 to determine periosteal-endosteal circle diameters (dp, de) and their eccentricity (e), and to calculate cross section's size-eccentricity factor. These and torque failure were substituted into the model to calculate bone material's effective tensile strength. RESULTS: @entity3604 compared with normal femurs had higher de/dp ratio (0.71 vs. 0.47), lower cross-sectional size-eccentricity factor (-41%), bone material strength (-57%), and torsional strength (-73%). Predicted % reduction in torsional strength by either concentric over reaming or canal eccentricity exponentially increases with increase in de/dp (notably beyond 0.47 of normal bone mineral density). CONCLUSIONS: Manufacturer's recommended 1.5 mm oversize RIA is conservative (<10% reduction) if concentric in femurs with isthmus de/dp < 0.60 mm and dp > 18.3 mm. An eccentric canal can significantly compromise a long bone's torsional strength, more than if reamed concentric to larger diameter having same minimum wall thickness. Other "safe/unsafe" oversize-eccentricity conditions are in quick clinical reference tables.

title: Predicting Reduction in Torsional Strength by Concentric/Eccentric RIA Reaming Normal and XXXX Long Bones (Femurs).

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['Osteoporotic']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['spiral fracture', 'spiral fractures']

entities_list: @entity19355 :: ('MESH:D005077', 'Disease') :: ['8-normal, 6-osteopenic, and 6-osteoporotic']

entities_list: @entity1048 :: ('MESH:D010522', 'Disease') :: ['Periosteal-endosteal circles']

answer: @entity3604 :: (MESH:D058866,Disease) :: ['Osteoporotic']


abstract: BACKGROUND: Suicide is a major clinical and public health issue, especially in @entity1 with disabilities. However, research on the acceptability of suicide in @entity1 with disabilities has not directly compared the relative acceptability of suicidality in @entity1 with and without disabilities. METHOD: An online sample of five hundred American adults read five pairs of vignettes about individuals who were experiencing suicidal ideation following a life stressor. Each pair contained a disability and no-disability condition; a sixth pair of vignettes discussed suicidal ideation in an elderly individual and contained physical and @entity73 conditions. @entity1 completed questions regarding the relative acceptability of suicidality for each vignette as well as demographic items and measures of suicidality, @entity308 , and attitude towards disability. RESULTS: In all vignette five pairs, suicidality was seen as significantly more acceptable in the disability condition; this was true even when the @entity1 themselves had disabilities or friends or family members with disabilities. Suicidality, depressive symptomology, and more negative attitudes towards disability predicted greater acceptability in both conditions; no factors predicted greater differences between the two conditions. LIMITATIONS: The vignettes in this study focused primarily on individuals in their 20s and most did not compare two disabling conditions. CONCLUSIONS: The greater social acceptability of suicidality in @entity1 with disabilities may be taken by individuals with disabilities who are suicidal as implicit permission to end their lives. The potential impact of such social influences should be assessed and addressed by clinicians and suicide prevention advocates.

title: Is suicide an option?: The impact of disability on suicide acceptability in the context of XXXX , suicidality, and demographic factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'people']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive disability']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: BACKGROUND: @entity548 remains the leading cause of @entity204 in @entity130 @entity1 . Proximal @entity432 , usually performed by direct aortic cross-clamping via thoracotomy, can provide temporary hemodynamic stability, permitting @entity130 repair. Resuscitative @entity432 of the aorta (REBOA) uses a minimally invasive, transfemoral balloon catheter, which is rapidly inserted retrograde and inflated for @entity432 , and may control inflow and allow time for hemostasis. We compared resuscitative thoracotomy with aortic cross-clamping ( @entity138 ) with REBOA in @entity130 @entity1 in profound @entity548 . METHODS: @entity130 registry data was used to compare all @entity1 undergoing @entity138 or REBOA during an 18-month period from two Level 1 @entity130 centers. RESULTS: There was no difference between @entity138 (n = 72) and REBOA groups (n = 24) in terms of demographics, mechanism of injury, or Injury Severity Scores (ISSs). There was no difference in chest and abdominal @entity130 ( @entity130 ) scores between the groups. However, the @entity138 @entity1 had lower extremity @entity130 score as compared with REBOA @entity1 (1.5 [0-3] vs. 4 [3-4], p < 0.001). Of the 72 @entity138 @entity1 , 45 (62.5%) died in the emergency department, 6 (8.3%) died in the operating room, and 14 (19.4%) died in the intensive care unit. Of the 24 REBOA @entity1 , 4 (16.6%) died in the emergency department, 3 (12.5%) died in the operating room, and 8 (33.3%) died in the intensive care unit. In comparing location of @entity204 between the @entity138 and REBOA groups, there were a significantly higher number of @entity204 in the emergency department among the @entity138 @entity1 as compared with the REBOA @entity1 (62.5% vs. 16.7%, p < 0.001). REBOA had fewer early @entity204 and improved overall survival as compared with @entity138 (37.5% vs. 9.7%, p = 0.003). CONCLUSION: REBOA is feasible and controls noncompressible @entity548 in @entity130 @entity1 in profound shock. @entity1 undergoing REBOA have improved overall survival and fewer early @entity204 as compared with @entity1 undergoing @entity138 . LEVEL OF EVIDENCE: Therapeutic study, level IV.

title: Implementation of resuscitative @entity432 of the aorta as an alternative to resuscitative thoracotomy for noncompressible XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['truncal hemorrhage', 'hemorrhagic shock', 'Hemorrhage']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['endovascular balloon occlusion', 'aortic occlusion']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['deaths', 'death']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['definitive injury', 'AIS', 'Trauma', 'trauma', 'Abbreviated Injury Scale']

answer: @entity548 :: (MESH:D006470,Disease) :: ['truncal hemorrhage']


abstract: BACKGROUND: @entity548 remains the leading cause of @entity204 in @entity130 @entity1 . Proximal @entity432 , usually performed by direct aortic cross-clamping via thoracotomy, can provide temporary hemodynamic stability, permitting @entity130 repair. Resuscitative @entity432 of the aorta (REBOA) uses a minimally invasive, transfemoral balloon catheter, which is rapidly inserted retrograde and inflated for @entity432 , and may control inflow and allow time for hemostasis. We compared resuscitative thoracotomy with aortic cross-clamping ( @entity138 ) with REBOA in @entity130 @entity1 in profound @entity548 . METHODS: @entity130 registry data was used to compare all @entity1 undergoing @entity138 or REBOA during an 18-month period from two Level 1 @entity130 centers. RESULTS: There was no difference between @entity138 (n = 72) and REBOA groups (n = 24) in terms of demographics, mechanism of injury, or Injury Severity Scores (ISSs). There was no difference in chest and abdominal @entity130 ( @entity130 ) scores between the groups. However, the @entity138 @entity1 had lower extremity @entity130 score as compared with REBOA @entity1 (1.5 [0-3] vs. 4 [3-4], p < 0.001). Of the 72 @entity138 @entity1 , 45 (62.5%) died in the emergency department, 6 (8.3%) died in the operating room, and 14 (19.4%) died in the intensive care unit. Of the 24 REBOA @entity1 , 4 (16.6%) died in the emergency department, 3 (12.5%) died in the operating room, and 8 (33.3%) died in the intensive care unit. In comparing location of @entity204 between the @entity138 and REBOA groups, there were a significantly higher number of @entity204 in the emergency department among the @entity138 @entity1 as compared with the REBOA @entity1 (62.5% vs. 16.7%, p < 0.001). REBOA had fewer early @entity204 and improved overall survival as compared with @entity138 (37.5% vs. 9.7%, p = 0.003). CONCLUSION: REBOA is feasible and controls noncompressible @entity548 in @entity130 @entity1 in profound shock. @entity1 undergoing REBOA have improved overall survival and fewer early @entity204 as compared with @entity1 undergoing @entity138 . LEVEL OF EVIDENCE: Therapeutic study, level IV.

title: Implementation of resuscitative XXXX of the aorta as an alternative to resuscitative thoracotomy for noncompressible @entity548 .

answer: @entity432 :: (MESH:D001157,Disease) :: ['endovascular balloon occlusion']


abstract: BACKGROUND: @entity5327 -reperfusion (I/R) injury is a serious pathophysiologic process that can trigger the development of @entity409 . @entity647 is a major cause of @entity204 among mesenteric I/R @entity1 , as current treatments remain inadequate. Stem cell-based therapies are considered novel strategies for treating several devastating and incurable diseases. This study examined whether induced pluripotent stem cells (iPSCs) lacking c-myc (i.e., induced using only the three genes @entity7002 , @entity14231 , and @entity2005 ) can protect against @entity647 in a mesenteric I/R @entity19 model. METHODS: C57BL/6 @entity19 were randomly divided into the following groups: sham/no treatment, vehicle treatment with @entity4613 -buffered saline, treatment with iPSCs, and treatment with iPSC-conditioned medium. The @entity19 were subjected to @entity5327 for 45 minutes followed by reperfusion for 24 hours. After I/R, the lungs and the ileum of the @entity19 were harvested. @entity651 was evaluated by histology, immunohistochemistry, and analyses of the levels of inflammatory cytokines, cleaved caspase 3, and @entity11838 . RESULTS: The intravenously delivered iPSCs engrafted to the lungs and the ileum in response to mesenteric I/R injury. Compared with the @entity4613 -buffered saline-treated group, the iPSC-treated group displayed a decreased intensity of @entity647 24 hours after mesenteric I/R. iPSC transplantation significantly reduced the expression of proinflammatory cytokines, oxidative stress markers, and apoptotic factors in injured lung tissue and remarkably enhanced endogenous alveolar cell proliferation. iPSC-conditioned medium treatment exerted a partial effect compared with iPSC treatment. CONCLUSION: When considering the anti-inflammatory, antioxidant, and antiapoptotic properties of iPSCs, the transplantation of iPSCs may represent an effective treatment option for mesenteric I/R-induced @entity647 .

title: Induced pluripotent stem cells alleviate @entity651 from XXXX -reperfusion.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['multiorgan dysfunction']

entities_list: @entity651 :: ('MESH:D055370', 'Disease') :: ['Lung injury']

entities_list: @entity5327 :: ('MESH:D065666', 'Disease') :: ['Mesenteric ischemia', 'mesenteric ischemia']

entities_list: @entity11838 :: ('MESH:C027576', 'Chemical') :: ['4-hydroxynonenal']

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury', 'Acute lung injury']

answer: @entity5327 :: (MESH:D065666,Disease) :: ['mesenteric ischemia']


abstract: BACKGROUND: @entity5327 -reperfusion (I/R) injury is a serious pathophysiologic process that can trigger the development of @entity409 . @entity647 is a major cause of @entity204 among mesenteric I/R @entity1 , as current treatments remain inadequate. Stem cell-based therapies are considered novel strategies for treating several devastating and incurable diseases. This study examined whether induced pluripotent stem cells (iPSCs) lacking c-myc (i.e., induced using only the three genes @entity7002 , @entity14231 , and @entity2005 ) can protect against @entity647 in a mesenteric I/R @entity19 model. METHODS: C57BL/6 @entity19 were randomly divided into the following groups: sham/no treatment, vehicle treatment with @entity4613 -buffered saline, treatment with iPSCs, and treatment with iPSC-conditioned medium. The @entity19 were subjected to @entity5327 for 45 minutes followed by reperfusion for 24 hours. After I/R, the lungs and the ileum of the @entity19 were harvested. @entity651 was evaluated by histology, immunohistochemistry, and analyses of the levels of inflammatory cytokines, cleaved caspase 3, and @entity11838 . RESULTS: The intravenously delivered iPSCs engrafted to the lungs and the ileum in response to mesenteric I/R injury. Compared with the @entity4613 -buffered saline-treated group, the iPSC-treated group displayed a decreased intensity of @entity647 24 hours after mesenteric I/R. iPSC transplantation significantly reduced the expression of proinflammatory cytokines, oxidative stress markers, and apoptotic factors in injured lung tissue and remarkably enhanced endogenous alveolar cell proliferation. iPSC-conditioned medium treatment exerted a partial effect compared with iPSC treatment. CONCLUSION: When considering the anti-inflammatory, antioxidant, and antiapoptotic properties of iPSCs, the transplantation of iPSCs may represent an effective treatment option for mesenteric I/R-induced @entity647 .

title: Induced pluripotent stem cells alleviate XXXX from @entity5327 -reperfusion.

answer: @entity651 :: (MESH:D055370,Disease) :: ['lung injury']


abstract: BACKGROUND: Bone marrow (BM) dysfunction following experimental @entity358 ( @entity358 ) resolves in 7 days; however, if followed by chronic stress (CS) following, @entity236 is persistent. Mesenchymal stem cells (MSCs) have protective immunomodulatory effects. We hypothesize that MSC can protect the BM against the deleterious effect of CS following @entity358 . METHODS: Male @entity35 (n = 6-7 per group) underwent @entity358 or @entity358 /CS    MSC injection. CS consisted of a daily 2-hour period of restraint with repositioning and alarming every 30 minutes to prevent @entity734 . A single intravenous dose of 5 * 10 MSCs was given within 10 minutes following @entity358 . Animals were sacrificed at Day 7, and peripheral blood (PB) and BM were collected. Flow cytometry was used to assess hematopoietic progenitor cells (HPCs) mobilized to PB. Plasma @entity7420 ( @entity7420 ) levels were measured by enzyme-linked immunosorbent assay. BM cellularity and growth of BM @entity4306 colonies (colony-forming unit-erythroid [CFU-E], burst-forming unit-erythroid [BFU-E], colony-forming unit-granulocyte, erythrocyte, monocyte, megakaryocyte [CFU-GEMM]) were also evaluated. RESULTS: As previously reported, the addition of CS to @entity358 resulted in a 32% decrease in BM cellularity; significant decreases in CFU-GEMM, BFU-E, and CFU-E; and marked increase in @entity4306 in the PB as compared with the naive animals. The addition of MSC to @entity358 /CS resulted in a 22% increase in BM cellularity and significant increases in CFU-GEMM, BFU-E, and CFU-E cultured from the BM. MSCs additionally reduced plasma @entity7420 , prevented prolonged mobilization of @entity4306 to PB, and restored colony growth to naive levels. CONCLUSION: CS following @entity358 results in persistent @entity236 manifested by a significant decrease in cellularity, @entity4306 colony growth, and increased @entity7420 levels and @entity4306 mobilization to the PB at 7 days following injury. The addition of a single dose of MSCs following acute @entity130 reverses the deleterious effects of CS on BM function. Further study is warranted to better understand the mechanisms behind MSC-mediated protection of BM function in the setting of CS.

title: Mesenchymal stem cells reverse bone XXXX following injury and stress.

entities_list: @entity7420 :: ('25610(Tax:10116)', 'Gene') :: ['granulocyte colony-stimulating factor', 'G-CSF']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['LC', 'lung contusion']

entities_list: @entity35 :: ('10116', 'Species') :: ['Sprague-Dawley rats']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['BM dysfunction']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['habituation']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury']

answer: @entity236 :: (MESH:D001855,Disease) :: ['marrow dysfunction']


abstract: Fourteen @entity1 with severe @entity28 resistant to previous dietetic measures underwent intestinal bypass using Scott's method. Weight loss ranged from 1-2 kg to 50 kg (mean = 25 kg) but weas unpredictable and varied from @entity1 to @entity1 ; most remained @entity28 . The other results of the operation were similar to those already reported. There was a decrease in total plasma @entity165 , while HDL @entity165 remained normal. Calcaemia was in the lower range of normal values; one @entity1 developed severe hypokaliaemia (1.8 mEq); low blood @entity1760 levels and steatorrhoea were common. @entity1575 was observed in one @entity1 and probably in another. Five @entity1 were re-operated upon for incisional @entity547 or @entity432 . Other complications reported in the literature ( @entity1151 , @entity4841 , @entity1290 and @entity5990 ) did not occur in this series. Because of these complications we decided to stop using intestinal bypass for the treatment of severe @entity28 . However, in view of the potential dangers of severe @entity28 we feel that other surgical techniques, such as Mason's gastric bypass, should be considered in some @entity1 .

title: [Intestinal bypass in the treatment of XXXX . Results of 14 cases (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity5990 :: ('MESH:D042882', 'Disease') :: ['gall stones']

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['kidney stones']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['intestinal occlusion']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['Fibrosis of the liver']

entities_list: @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgias']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: UNASSIGNED: Metal phosphides such as @entity26444 are potent insecticides. This highly toxic substance is used for @entity579 and other grains protection in Iran. Due to its high @entity137 potential and easy availability, it is widely used as a suicide poison. This substance has no effective antidote and the incidence of @entity204 due to its @entity4968 is increasing day by day in Iran.The present study was conducted to show the increasing incidence of fatal @entity26444 @entity4968 and its toxicological and forensic aspects in an 8-year study, 2006 to 2013. Autopsy sheets were reviewed and cases with the history of @entity26444 @entity4968 were selected. Toxicological analysis results, demographic and necroscopic examination findings were studied. A total of 51.8% of studied cases were female. Most of the cases were between 10 and 40 years old. The manner of @entity204 was self- @entity4968 in 85% of cases. @entity1286 , @entity1068 , and @entity3659 were the most common additional drugs detected in toxicological analysis. The incidence of fatal @entity26444 @entity4968 cases referred for @entity29281 analysis was 5.22 and 37.02 per million of population of Tehran in 2006 and 2013, respectively. The results of this study showed that in spite of ban and restrictions, there was a dramatic increase in the incidence of fatal @entity26444 @entity4968 in Tehran from 2006 to 2013. Safety alert should be highlighted in training program for all population groups about the toxic effects of @entity26444 tablets.

title: XXXX Poisoning-Related Deaths in Tehran, Iran, 2006 to 2013.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity3659 :: ('MESH:D000639', 'Chemical') :: ['amitriptyline']

entities_list: @entity4968 :: ('MESH:D011041', 'Disease') :: ['poisoning']

entities_list: @entity29281 :: ('MESH:C044646', 'Chemical') :: ['phosphine']

entities_list: @entity1286 :: ('MESH:D009020', 'Chemical') :: ['Morphine']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

entities_list: @entity26444 :: ('MESH:C001864', 'Chemical') :: ['aluminum phosphide']

answer: @entity26444 :: (MESH:C001864,Chemical) :: ['Aluminum Phosphide']


abstract: UNASSIGNED: Studies comparing @entity62 ( @entity62 ) volume of @entity161 @entity1 with or without auditory verbal @entity1833 (AVHs) to that of normal controls remain controversial. This project aims to investigate changes of @entity62 volumes of drug-na  ve @entity161 @entity1 with and without AVHs. Eighteen first episode @entity161 (FES) @entity1 with AVHs, 18 FES @entity1 without AVHs, and 18 healthy controls were scanned using structural MRI. Voxel-based morphometry (VBM) analysis was conducted to investigate changes of @entity62 volume among the three groups. @entity1 with and without AVHs exhibited reduced @entity62 volumes relative to normal controls in the left superior temporal gyrus, frontal regions, cerebellum and caudate. Further analysis of the @entity62 of subcortical structures found that @entity1 with AVHs had reduced thalamic volume than healthy controls. No significant difference was found between @entity1 with and without AVHs. Significant correlation was found between the total scores of the Positive and Negative Syndrome Scale and bilateral thalamic volume. ROC analysis of thalamic volumes of the @entity1 with AVHs and normal controls showed that the area under the curve was 0.698 (P   =   0.043). The decreased thalamic volumes might serve as a biomarker for discriminating FES AVHs @entity1 from normals.

title: Decreased bilateral thalamic XXXX volume in first-episode @entity161 with prominent hallucinatory symptoms: A volumetric MRI study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['gray matter', 'GM']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenic']

entities_list: @entity1833 :: ('MESH:D006212', 'Disease') :: ['hallucinations']

answer: @entity62 :: (MESH:D056784,Disease) :: ['gray matter']


abstract: UNASSIGNED: Studies comparing @entity62 ( @entity62 ) volume of @entity161 @entity1 with or without auditory verbal @entity1833 (AVHs) to that of normal controls remain controversial. This project aims to investigate changes of @entity62 volumes of drug-na  ve @entity161 @entity1 with and without AVHs. Eighteen first episode @entity161 (FES) @entity1 with AVHs, 18 FES @entity1 without AVHs, and 18 healthy controls were scanned using structural MRI. Voxel-based morphometry (VBM) analysis was conducted to investigate changes of @entity62 volume among the three groups. @entity1 with and without AVHs exhibited reduced @entity62 volumes relative to normal controls in the left superior temporal gyrus, frontal regions, cerebellum and caudate. Further analysis of the @entity62 of subcortical structures found that @entity1 with AVHs had reduced thalamic volume than healthy controls. No significant difference was found between @entity1 with and without AVHs. Significant correlation was found between the total scores of the Positive and Negative Syndrome Scale and bilateral thalamic volume. ROC analysis of thalamic volumes of the @entity1 with AVHs and normal controls showed that the area under the curve was 0.698 (P   =   0.043). The decreased thalamic volumes might serve as a biomarker for discriminating FES AVHs @entity1 from normals.

title: Decreased bilateral thalamic @entity62 volume in first-episode XXXX with prominent hallucinatory symptoms: A volumetric MRI study.

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: PURPOSE: To investigate the microbiological profile of @entity282 in a referral center in Tunisia and to assess the antibiotic sensitivity of the organisms. @entity1 AND METHODS: This is a retrospective study over a period of eleven years, conducted on @entity1 hospitalized with acute @entity86 . Cultures were performed on aqueous (93%) and vitreous specimens (68%) obtained at presentation. Each sample underwent direct examination, culture and antibiotic susceptibilities. RESULTS: The number of @entity282 cases identified during the study period was 308. Organisms were found in 43% of samples ( @entity3225 was bacterial in 39.5%, fungal in 0.9% and polymicrobial in 2.6%). Cultures grew primarily @entity5938 in 31.4% of cases, @entity328 in 22.7% of cases and @entity794 in 12.7% of cases. Gram-positive cocci are more sensitive to @entity2176 and Gram-negative bacilli are more susceptible to @entity800 and @entity2177 . CONCLUSION: In our study, microbiological samples were positive in 43% and coagulase-negative Gram-positive cocci are the most common organisms. However, antibiotic resistance has been increasing over the years.

title: [Microbiological profile of XXXX in a referral centre in Tunisia].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin']

entities_list: @entity5938 :: ('1282', 'Species') :: ['Staphylococcus epidermidis']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity2177 :: ('MESH:D002939', 'Chemical') :: ['ciprofloxacin']

entities_list: @entity800 :: ('MESH:D015242', 'Chemical') :: ['ofloxacin']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['infectious postoperative endophthalmitis']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['acute postoperative endophthalmitis']

entities_list: @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']

entities_list: @entity3225 :: ('MESH:D009877', 'Disease') :: ['endophthalmitis']

answer: @entity3225 :: (MESH:D009877,Disease) :: ['endophthalmitis']


abstract: OBJECTIVE: To measure the long-term impact of surgical treatment for @entity5 upon health-related quality of life and pelvic floor outcomes during the first year of therapy. METHODS: Prospective, longitudinal, mixed-methods study. Twenty-three @entity1 aged >18  years with a new diagnosis of @entity5 were recruited. The EORTC QLQ C30, SF-36 and an electronic pelvic floor assessment questionnaire (ePAQ-PF) were administered at baseline (pre-treatment) and 3, 6, 9 and 12  months post-treatment. Mixed effects repeated measures models (all adjusted for age and BMI) were used to investigate changes over time and differences between @entity5 stage. Qualitative interviews were carried out with 11 of the @entity1 and analysed using a thematic approach. RESULTS: Mean age was 59.9  years (SD   =   15.3; range   =   23.8-86.6  yrs). Mean BMI was 30.0 (SD   =   4.5; range   =   24.4-38.2). Sixteen @entity1 had early (Stage 1 to 2B), and seven @entity1 had advanced stage disease (Stage 3 to 4B). Questionnaire scores revealed that physical and social functioning, fatigue, @entity158 and general sex life were significantly worse at 12  months than pre-treatment (p   =   < 0.05). Qualitative analysis revealed multiple treatment side effects which were perceived as severe and enduring. @entity1 with advanced @entity5 had significantly worse SF-36 mental health scores at 12  months compared to @entity1 with early stage disease (p   =   0.037). CONCLUSIONS: Surgery for @entity5 has long-term implications which can be persistent 12  months post-treatment. High rates of morbidity relating to lymphoedema and sexual function re-enforce the need for specialist clinics to support @entity1 who suffer these complications.    2015 The Authors. Psycho-Oncology published by John Wiley _ Sons Ltd.

title: The impact of surgery for XXXX upon health-related quality of life and pelvic floor outcomes during the first year of treatment: a longitudinal, mixed methods study.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['vulval cancer', 'cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['vulval cancer']


abstract: During the past seven years, a total of 1,713 @entity1 underwent strumectomy for a variety of causes at the University of D  sseldorf. Unilateral palsies of the recurrent nerve developed in 147 @entity1 . Both vocal cords were paralyzed in 22 @entity1 . Of the 147 @entity1 with unilateral palsies, 53 @entity1 were available for follow-up examination after one year. In 28 of these @entity1 , complete paresis of the vocal cord remained. Twenty-three @entity1 showed complete recovery and normal function of the affected cord. In two @entity1 , reduced but marked mobility of the previously completely paralyzed vocal cord was present. Of the 22 @entity1 with bilateral recurrent @entity129 , 10 were available for follow-up examination one year later. In three of these @entity1 vocal @entity717 was still absent, in three others one vocal cord showed normal function, and in only one @entity1 did both vocal cords reveal normal physiologic mobility. Three other @entity1 demonstrated a reduced but marked mobility of one vocal cord. The results are discussed in relation to the clinical and histologic data.

title: Postoperative recurrent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['cord movement']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['nerve palsies']

answer: @entity129 :: (MESH:D003389,Disease) :: ['nerve palsy']


abstract: BACKGROUND: When individuals with asymmetric lower extremities present for evaluation of limb-length inequality, correction can occur at the tibia, femur, or in both bones; however, there are limited data available to justify either technique. The aim of this study is to examine the normal ratio of tibia length/femur length (T/F), and to explore the relationship between T/F ratio and @entity571 of the spine, hips, and knees. METHODS: Bone lengths of 1152 cadaveric femora and tibiae from the Hamann-Todd osteological collection were measured. @entity179 was graded in the hip, knee, and spine. Correlations between the ratio of T/F and @entity571 were evaluated with multiple regression analysis. RESULTS: The average ratio of T/F was 0.80  0.03. There was a strong correlation between age and @entity625 at all sites, with standardized b ranging from 0.44 to 0.57 (P<0.0005 for all). There was a significant correlation between increasing T/F and @entity625 (standardized b=0.08, P=0.006), and knee @entity625 (standardized b=0.08, P=0.008). DISCUSSION: Increasing tibia length relative to femur length was found to be a significant predictor of ipsilateral hip and knee @entity625 . Therefore, we recommend that when performing limb lengthening, surgical planning should lean toward recreating the normal ratio of 0.80. In circumstances where one bone is to be overlengthened relative to the other, bias should be toward overlengthening the femur. This same principle can be applied to limb-reduction surgery, where in certain circumstances, one may choose to preferentially shorten the tibia. CLINICAL RELEVANCE: This is the first study to report long-term consequences of lower @entity1347 .

title: The Association of Tibia Femur Ratio and XXXX of the Spine, Hips, and Knees.

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['extremity segment disproportion']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['Degenerative joint disease']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['hip arthritis', 'arthritis']

answer: @entity179 :: (MESH:D019636,Disease) :: ['Degenerative Disease']


abstract: The role of @entity1482 and @entity14292 in @entity1 with @entity712 with preserved Ejection Fraction (HFpEF) is not well defined. Since a growing medical literature has suggested that mineralocorticoid receptor antagonists may be beneficial for @entity1 with HFpEF, this review gives an in-depth update on the role of @entity1482 and @entity14292 and their implications for therapy in the setting of HFpEF. Eleven clinical studies, including seven randomized trials, were reviewed. Two randomized controlled trials evaluated the effect of @entity14292 on different end-points, including 6minute walk distance (6MWD), cardiovascular mortality, non-fatal reinfarction, hospitalization for unstable @entity951 and @entity712 . @entity14292 did not affect either 6MWD or event-free survival rates in the overall study population in these two reports. The effects of @entity1482 on similar composite endpoints were evaluated in 7 studies in @entity1 with HFpEF. Compared to placebo, hospitalization for @entity712 was significantly lower in the @entity1482 group and @entity1482 was also shown to improve diastolic function and induced beneficial remodeling through a reduction in @entity296 . The safety profile of @entity1482 and @entity14292 has been assessed in two recent studies. Data showed that @entity14292 and @entity1482 are both associated with the occurrence of @entity247 , @entity5026 , and abnormal @entity3556 and in addition, they can increase natriuresis and cause renal retention of @entity972 ; furthermore, @entity14292 may cause @entity4144 and promote the onset of @entity520 or @entity2753 . In conclusion although the mineralocorticoid receptor antagonists @entity14292 and @entity1482 improve clinical outcomes in @entity1 with HFrEF, additional data will be necessary to better define their risk-benefit profile, especially for @entity14292 , in the treatment of HFpEF.

title: Mineralocorticoid receptor antagonists in XXXX with preserved ejection fraction (HFpEF).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'Heart Failure', 'heart failure']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial fibrosis']

entities_list: @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding']

entities_list: @entity5026 :: ('MESH:D059373', 'Disease') :: ['mastodynia']

entities_list: @entity14292 :: ('MESH:C414690', 'Chemical') :: ['eplerenone', 'Eplerenone']

entities_list: @entity2753 :: ('MESH:D007010', 'Disease') :: ['hyponatremia']

entities_list: @entity247 :: ('MESH:D006177', 'Disease') :: ['gynecomastia']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['metabolic acidosis']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity1482 :: ('MESH:D013148', 'Chemical') :: ['spironolactone']

entities_list: @entity4144 :: ('MESH:D006947', 'Disease') :: ['hyperkalemia']

answer: @entity712 :: (MESH:D006333,Disease) :: ['heart failure']


abstract: PURPOSE: The aim of this study is to characterize the patterns of medication use by @entity0 ( @entity0 ) survivors from diagnosis to 1  year post-chemotherapy. METHODS: A single-center longitudinal study was conducted with @entity0 @entity1 diagnosed between December 2011 and June 2014. Data on the medication use of individual @entity1 were retrieved from prescription databases, supplemented by records from the National Electronic Health Records. The data covered the period from @entity0 diagnosis to 1  year post-chemotherapy. Medication types were classified according to the World Health Organization's Anatomical Therapeutic Chemical classification system, and medication for @entity102 was created by adapting a list of 20 @entity102 provided by the U.S. Department of @entity1 and Health Services. RESULTS: Of the 107 @entity1 involved in the study (mean age 51.1        8.4  years; 78.5  % Chinese), 46.7  % manifested non- @entity5 comorbidities, of which @entity101 (24.3  %) was the most prevalent, followed by @entity407 (13.1  %) and @entity6 (5.6  %). @entity460 channel blockers (12.1  %) and lipid-modifying agents (11.2  %) were the most common chronic medication types used before chemotherapy, and their use persisted during chemotherapy (10.3 and 11.2  %, respectively) and after chemotherapy (11.2 and 13.1  %, respectively). Hormonal therapy was the predominant post-chemotherapy medication (77.6  %). A statistically significant increase (p   <   0.0001) was observed in the mean number of chronic disease medication classes prescribed to @entity1 between the pre-chemotherapy (0.53        1.04) and chemotherapy (0.62        1.08) periods and between the chemotherapy and post-chemotherapy (1.63        1.35) periods. CONCLUSIONS: There is an increase in trend of chronic medication usage in @entity0 survivors after @entity5 treatment. This study provides important insights into the design of medication management programs tailored to this population. Future studies should incorporate a control population to improve the interpretation of study results.

title: Medication use by XXXX survivors: a 1-year longitudinal study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Human']

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'ESBC', 'early-stage breast cancer']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['Calcium']

answer: @entity0 :: (MESH:D001943,Disease) :: ['early-stage breast cancer']


abstract: UNASSIGNED: This study investigated the expression of @entity14215 and @entity3546 in @entity0 @entity1 , and analyzed the correlation of their combined expression with clinicopathological features, chemotherapeutic responses, and prognosis of @entity0 @entity1 . In total 276  @entity1 @entity0 tissues and 80  benign hyperplasia tissues were included. The expression of @entity14215 and @entity3546 was examined using tissue microarray-based immunohistochemistry. ROC curve analysis was performed to determine an optimal cut-off score for the expression of @entity14215 and @entity3546 , based on the survival status of @entity0 @entity1 . Survival probabilities were estimated by the Kaplan-Meier method. @entity14215 expression was higher, but @entity3546 showed no significant difference in @entity0 samples compared to controls. Compared with the membrane expression of @entity3546 [ @entity3546 (m)], the cytoplasmic expression of @entity3546 [ @entity3546 (c)] occurred significantly more frequently in @entity0 with the @entity14215 expression of @entity14215 [ @entity14215 ( @entity14215 )] than in @entity0 with the low expression of @entity14215 [ @entity14215 (low)] (P=0.014). The expression level of ALDH1A was significantly higher in @entity3546 (c) @entity0 than in @entity3546 (m) @entity0 (P=0.020). @entity14215 ( @entity14215 ) expression or @entity3546 (c) expression alone was associated with @entity1600 , and worse clinical outcome in @entity0 @entity1 , especially in @entity1 receiving @entity786 treatment. Combined expression of @entity14215 and @entity3546 (c) was associated with @entity1600 , poor outcome, and resistance to @entity786 treatment. @entity3546 may regulate @entity14215 expression in a subtype of @entity0 with @entity14215 and @entity3546 (c) expression. @entity14215 and @entity3546

title: Combined expression of aldehyde dehydrogenase 1A1 and XXXX is associated with @entity1600 and poor survival in @entity0 @entity1 following @entity786 treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['lymph node metastasis']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

answer: @entity3546 :: (1499,Gene) :: ['b-catenin']


abstract: UNASSIGNED: This study investigated the expression of @entity14215 and @entity3546 in @entity0 @entity1 , and analyzed the correlation of their combined expression with clinicopathological features, chemotherapeutic responses, and prognosis of @entity0 @entity1 . In total 276  @entity1 @entity0 tissues and 80  benign hyperplasia tissues were included. The expression of @entity14215 and @entity3546 was examined using tissue microarray-based immunohistochemistry. ROC curve analysis was performed to determine an optimal cut-off score for the expression of @entity14215 and @entity3546 , based on the survival status of @entity0 @entity1 . Survival probabilities were estimated by the Kaplan-Meier method. @entity14215 expression was higher, but @entity3546 showed no significant difference in @entity0 samples compared to controls. Compared with the membrane expression of @entity3546 [ @entity3546 (m)], the cytoplasmic expression of @entity3546 [ @entity3546 (c)] occurred significantly more frequently in @entity0 with the @entity14215 expression of @entity14215 [ @entity14215 ( @entity14215 )] than in @entity0 with the low expression of @entity14215 [ @entity14215 (low)] (P=0.014). The expression level of ALDH1A was significantly higher in @entity3546 (c) @entity0 than in @entity3546 (m) @entity0 (P=0.020). @entity14215 ( @entity14215 ) expression or @entity3546 (c) expression alone was associated with @entity1600 , and worse clinical outcome in @entity0 @entity1 , especially in @entity1 receiving @entity786 treatment. Combined expression of @entity14215 and @entity3546 (c) was associated with @entity1600 , poor outcome, and resistance to @entity786 treatment. @entity3546 may regulate @entity14215 expression in a subtype of @entity0 with @entity14215 and @entity3546 (c) expression. @entity14215 and @entity3546

title: Combined expression of aldehyde dehydrogenase 1A1 and @entity3546 is associated with @entity1600 and poor survival in @entity0 @entity1 following XXXX treatment.

answer: @entity786 :: (MESH:D003520,Chemical) :: ['cyclophosphamide']


abstract: UNASSIGNED: This study investigated the expression of @entity14215 and @entity3546 in @entity0 @entity1 , and analyzed the correlation of their combined expression with clinicopathological features, chemotherapeutic responses, and prognosis of @entity0 @entity1 . In total 276  @entity1 @entity0 tissues and 80  benign hyperplasia tissues were included. The expression of @entity14215 and @entity3546 was examined using tissue microarray-based immunohistochemistry. ROC curve analysis was performed to determine an optimal cut-off score for the expression of @entity14215 and @entity3546 , based on the survival status of @entity0 @entity1 . Survival probabilities were estimated by the Kaplan-Meier method. @entity14215 expression was higher, but @entity3546 showed no significant difference in @entity0 samples compared to controls. Compared with the membrane expression of @entity3546 [ @entity3546 (m)], the cytoplasmic expression of @entity3546 [ @entity3546 (c)] occurred significantly more frequently in @entity0 with the @entity14215 expression of @entity14215 [ @entity14215 ( @entity14215 )] than in @entity0 with the low expression of @entity14215 [ @entity14215 (low)] (P=0.014). The expression level of ALDH1A was significantly higher in @entity3546 (c) @entity0 than in @entity3546 (m) @entity0 (P=0.020). @entity14215 ( @entity14215 ) expression or @entity3546 (c) expression alone was associated with @entity1600 , and worse clinical outcome in @entity0 @entity1 , especially in @entity1 receiving @entity786 treatment. Combined expression of @entity14215 and @entity3546 (c) was associated with @entity1600 , poor outcome, and resistance to @entity786 treatment. @entity3546 may regulate @entity14215 expression in a subtype of @entity0 with @entity14215 and @entity3546 (c) expression. @entity14215 and @entity3546

title: Combined expression of aldehyde dehydrogenase 1A1 and @entity3546 is associated with XXXX and poor survival in @entity0 @entity1 following @entity786 treatment.

answer: @entity1600 :: (MESH:D014388,Disease) :: ['lymph node metastasis']


abstract: UNASSIGNED: This study investigated the expression of @entity14215 and @entity3546 in @entity0 @entity1 , and analyzed the correlation of their combined expression with clinicopathological features, chemotherapeutic responses, and prognosis of @entity0 @entity1 . In total 276  @entity1 @entity0 tissues and 80  benign hyperplasia tissues were included. The expression of @entity14215 and @entity3546 was examined using tissue microarray-based immunohistochemistry. ROC curve analysis was performed to determine an optimal cut-off score for the expression of @entity14215 and @entity3546 , based on the survival status of @entity0 @entity1 . Survival probabilities were estimated by the Kaplan-Meier method. @entity14215 expression was higher, but @entity3546 showed no significant difference in @entity0 samples compared to controls. Compared with the membrane expression of @entity3546 [ @entity3546 (m)], the cytoplasmic expression of @entity3546 [ @entity3546 (c)] occurred significantly more frequently in @entity0 with the @entity14215 expression of @entity14215 [ @entity14215 ( @entity14215 )] than in @entity0 with the low expression of @entity14215 [ @entity14215 (low)] (P=0.014). The expression level of ALDH1A was significantly higher in @entity3546 (c) @entity0 than in @entity3546 (m) @entity0 (P=0.020). @entity14215 ( @entity14215 ) expression or @entity3546 (c) expression alone was associated with @entity1600 , and worse clinical outcome in @entity0 @entity1 , especially in @entity1 receiving @entity786 treatment. Combined expression of @entity14215 and @entity3546 (c) was associated with @entity1600 , poor outcome, and resistance to @entity786 treatment. @entity3546 may regulate @entity14215 expression in a subtype of @entity0 with @entity14215 and @entity3546 (c) expression. @entity14215 and @entity3546

title: Combined expression of aldehyde dehydrogenase 1A1 and @entity3546 is associated with @entity1600 and poor survival in XXXX @entity1 following @entity786 treatment.

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: UNASSIGNED: This study investigated the expression of @entity14215 and @entity3546 in @entity0 @entity1 , and analyzed the correlation of their combined expression with clinicopathological features, chemotherapeutic responses, and prognosis of @entity0 @entity1 . In total 276  @entity1 @entity0 tissues and 80  benign hyperplasia tissues were included. The expression of @entity14215 and @entity3546 was examined using tissue microarray-based immunohistochemistry. ROC curve analysis was performed to determine an optimal cut-off score for the expression of @entity14215 and @entity3546 , based on the survival status of @entity0 @entity1 . Survival probabilities were estimated by the Kaplan-Meier method. @entity14215 expression was higher, but @entity3546 showed no significant difference in @entity0 samples compared to controls. Compared with the membrane expression of @entity3546 [ @entity3546 (m)], the cytoplasmic expression of @entity3546 [ @entity3546 (c)] occurred significantly more frequently in @entity0 with the @entity14215 expression of @entity14215 [ @entity14215 ( @entity14215 )] than in @entity0 with the low expression of @entity14215 [ @entity14215 (low)] (P=0.014). The expression level of ALDH1A was significantly higher in @entity3546 (c) @entity0 than in @entity3546 (m) @entity0 (P=0.020). @entity14215 ( @entity14215 ) expression or @entity3546 (c) expression alone was associated with @entity1600 , and worse clinical outcome in @entity0 @entity1 , especially in @entity1 receiving @entity786 treatment. Combined expression of @entity14215 and @entity3546 (c) was associated with @entity1600 , poor outcome, and resistance to @entity786 treatment. @entity3546 may regulate @entity14215 expression in a subtype of @entity0 with @entity14215 and @entity3546 (c) expression. @entity14215 and @entity3546

title: Combined expression of aldehyde dehydrogenase 1A1 and @entity3546 is associated with @entity1600 and poor survival in @entity0 XXXX following @entity786 treatment.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Falls that occur as a result of a slip are one of the leading causes of @entity130 , particularly in the elderly population. Previous studies have focused on slips that occur on a flat surface. Slips on a laterally sloping surface are important and may be related to different mechanisms of balance recovery. This type of slip might result in different gait adaptations to those previously described on a flat surface, but these adaptations have not been investigated. The aim of this study was to assess whether, when walking on a @entity2915 , young adults adapted their gait when made aware of a potential slip, and having experienced a slip. Gait parameters were compared for three conditions-(1) Normal walking; (2) Walking after being made aware of a potential slip ( @entity1 were told that a slip may occur); (3) Walking after experiencing a slip ( @entity1 had already experienced at least one slip induced using a soapy contaminant). Gait parameters were only analysed for trials in which there was no slippery contaminant present on the walkway. Stride length and walking velocity were significantly reduced, and stance duration was significantly greater in the awareness and experience conditions compared to normal walking, with no significant differences in any gait parameters between the awareness and experience conditions. In addition, 46.7% of the slip trials resulted in a fall. This is higher than reported for slips induced on a flat surface, suggesting slips on a @entity2915 are more hazardous. This would help explain the more cautious gait patterns observed in both the awareness and experience conditions.

title: Gait adaptations to awareness and experience of a slip when walking on a XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['cross-slope']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']

answer: @entity2915 :: (MESH:D006948,Disease) :: ['cross-slope']


abstract: OBJECTIVE: @entity43 ( @entity43 ) are rare, and uncertainty exists as to the optimal treatment paradigm and validity of the FIGO staging system, especially in early-stage disease. METHODS: We performed a retrospective cohort study of all OCCC @entity1 diagnosed and treated at Memorial Sloan Kettering Cancer Center between January 1996 and December 2013. Progression-free survival (PFS) and overall survival (OS) were calculated by stage and race, and comparisons were made using the log-rank test. Statistical significance was set at p<0.05. Type and duration of treatment were also recorded. RESULTS: There were 177 evaluable @entity1 . The majority of @entity1 were stage I at diagnosis (110/177, 62.2%). Of these, 60/110 (54.6%) were stage IA, 31/110 (28.2%) were stage IC on the basis of @entity397 -only, and 19/110 (17.3%) were stage IC on the basis of surface involvement and/or positive cytology of ascites or washings. @entity1 with stage IA and IC based on @entity397 -only had similar PFS/OS outcomes. @entity1 with stage IC based on surface involvement and/or positive cytology had a statistically significant decrement in PFS/OS. Stage was an important indicator of PFS/OS, while race was not. CONCLUSIONS: OCCC often presents in early stage. @entity1 with stage IA OCCC have excellent prognosis, and future studies should explore whether they benefit from adjuvant chemotherapy. @entity1 with IC OCCC need further staging clarification, as surgical @entity397 alone affords better prognosis than surface involvement and/or positive cytology. @entity1 with advanced OCCC have poor survival and are often chemotherapy resistant/refractory. New treatment paradigms are needed.

title: XXXX , outcomes by stage: The MSK experience.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Ovarian clear cell carcinomas', 'OCCCs']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Women']

answer: @entity43 :: (MESH:D010051,Disease) :: ['Ovarian clear cell carcinoma']


abstract: Eight hundred sixty-five @entity1 with confirmed @entity420 of the endometrium were studied. Eight hundred eleven were followed up for at least 5 years or until death, and 537 were followed up for 10 years. The survival rate was 77.1% at 5 years and 61.0% at 10 years. Age at diagnosis was the single most important clinical determinant of survival. @entity5 grade was an important predictor of the course of disease, and nuclear grade was a significantly more accurate indicator than was histologic grade. Stage and depth of invasion were also important predictors of survival. The 5-year survival rate for black @entity1 was only 41.9%. Stage for stage and grade for grade, @entity1 undergoing hysterectomy alone and with radiation had similar survival rates. Adenoacanthoma had a better prognosis that did @entity420 without @entity1544 ; there were no deaths at 5 to 10 years in @entity1 diagnosed before age 50. The subtype of @entity189 was found to be a highly significant predictor of prognosis.

title: Carcinoma of the endometrium. III. Analysis of 865 cases of XXXX and adenoacanthoma.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous metaplasia']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity420 :: (MESH:D000230,Disease) :: ['adenocarcinoma']


abstract: In three separate experiments the behaviour of Dermacentor andersoni larvae on normal and tick-resistant @entity840 was studied at intervals throughout 5-day @entity277 periods. Fewer larvae survived on resistant hosts and their mean sizes were less than those of larvae on normal hosts, the differences becoming more obvious as time progressed. When measured at 32 degrees C, the peristaltic rates of midgut diverticula of the larvae surviving on resistant hosts were consistently lower than those of larvae from normal hosts. Mean surface temperatures of infested ears were higher on resistant than on normal hosts. This was assumed to be a result of @entity56 in the resistant animals. Larvae detached, or changed attachment sites, more often on resistant than on normal hosts. This was consistently evident after 26 h post- @entity277 and correlated with the known timing of basophil cell infiltration and degranulation in the skin of infested, resistant @entity840 . It appeared that most larvae, after detaching from the resistant host, died off the host. However, some died in situ while still attached. Such @entity204 occurred on resistant but not on normal animals between 8 and 26 h post- @entity277 .

title: Observations on the behaviour of Dermacentor andersoni larvae infesting normal and tick resistant XXXX .

entities_list: @entity840 :: ('10141', 'Species') :: ['guinea pigs', 'guinea-pigs']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['cutaneous hypersensitivity reactions']

entities_list: @entity277 :: ('MESH:D013984', 'Disease') :: ['infestation']

answer: @entity840 :: (10141,Species) :: ['guinea-pigs']


abstract: PURPOSE: @entity571 of the knee is one of the most common diseases. For this @entity102 , modified footwear structure can effectively prevent and relieve disease of the knee. The aim of this study was to explore the effects of shoe surface elastic modulus on external knee adduction moment and ground reaction force and foot loading characteristics. METHODS: Sixteen healthy female volunteers were recruited, and each subject performed five walking trials under two shoes condition. The lower limb loading data was collected using force platform and in-sole pressure measurement system. RESULTS: The results showed that the external knee adduction moment was decreased in all stance phase when wearing SS (unstable shoes with soft unstable elements), compared with @entity8682 (unstable shoes with @entity3358 ). The ground reaction force showed no obvious change under two shoes condition. Additionally, compared with @entity551 transferred from medial foot to lateral foot when wearing SS. Along with changes of contact areas, average pressure and impulse had also presented this tendency. CONCLUSIONS: These results can provide some scientific evidence and suggestions for footwear companies, and for the foot plantar medial @entity66 has also certain applicability.

title: Effects of unstable elements with different XXXX on lower limb loading.

entities_list: @entity3358 :: ('MESH:D018804', 'Disease') :: ['hard unstable elements']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['injury disease']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['HS, plantar pressure']

answer: @entity3358 :: (MESH:D018804,Disease) :: ['hardness']