abstract: @entity1669 ( @entity1669 ) and @entity1723 ( @entity1723 ) frequently occur in the same individual pointing to a strong shared genetic susceptibility. Indeed, the co-occurrence of @entity1723 and @entity1669 in the same individual is classified as a variant of the @entity12010 type 3 (designated APS3v). Our aim was to identify new genes and mechanisms causing the co-occurrence of @entity1723 + @entity1669 (APS3v) in the same individual using a genome-wide approach. For our discovery set we analyzed 346 Caucasian APS3v @entity1 and 727 gender and ethnicity matched healthy controls. Genotyping was performed using the Illumina Human660W-Quad.v1. The replication set included 185 APS3v @entity1 and 340 controls. Association analyses were performed using the PLINK program, and pathway analyses were performed using the MAGENTA software. We identified multiple signals within the HLA region and conditioning studies suggested that a few of them contributed independently to the strong association of the HLA locus with APS3v. Outside the HLA region, variants in @entity72031 , a gene not suggested by previous studies of APS3v, @entity1723 , or @entity1669 , showed genome-wide significance (p < 5 * 10(-8)). In addition, a locus on 1p13 containing the @entity5812 gene showed genome-wide significant associations. Pathway analysis demonstrated that cell cycle, B-cell development, @entity2936 , and @entity4386 signaling were the major pathways contributing to the pathogenesis of APS3v. These findings suggest that complex mechanisms involving T-cell and B-cell pathways are involved in the strong genetic association between @entity1669 and @entity1723 .

title: Genome wide identification of new genes and pathways in XXXX with both autoimmune thyroiditis and type 1 diabetes.

entities_list: @entity1669 :: ('MESH:D013967', 'Disease') :: ['AITD', 'Autoimmune thyroid diseases']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['Type 1 diabetes', 'T1D']

entities_list: @entity12010 :: ('MESH:D016884', 'Disease') :: ['autoimmune polyglandular syndrome']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Capacitive radiofrequency (RF) @entity221 suffers from excessive temperature rise near the electrodes and poorly localized heat transfer to the deep-seated @entity5 region even though it is known to have potential to cure ill-conditioned @entity5 . To better localize heat transfer to the deep-seated target region in which electrical conductivity is elevated by nanoparticle mediation, two-channel capacitive RF heating has been tried on a phantom. METHODS: We made a tissue-mimicking phantom consisting of two compartments, a @entity5 -tissue-mimicking insert against uniform background agarose. The @entity5 -tissue-mimicking insert was made to have higher electrical conductivity than the normal-tissue-mimicking background by applying magnetic nanoparticle suspension to the insert. Two electrode pairs were attached on the phantom surface by equal-angle separation to apply RF electric field to the phantom. To better localize heat transfer to the @entity5 -tissue-mimicking insert, RF power with a frequency of 26  MHz was delivered to the two channels in a time-multiplexed way. To monitor the temperature rise inside the phantom, MR thermometry was performed at a 3T MRI intermittently during the RF heating. Finite-difference-time-domain (FDTD) electromagnetic and thermal simulations on the phantom model were also performed to verify the experimental results. RESULTS: As compared to the one-channel RF heating, the two-channel RF heating with time-multiplexed driving improved the spatial localization of heat transfer to the @entity5 -tissue-mimicking region in both the simulation and experiment. The two-channel RF heating also reduced the temperature rise near the electrodes significantly. CONCLUSIONS: Time-multiplexed two-channel capacitive RF heating has the capability to better localize heat transfer to the nanoparticle-mediated @entity5 region which has higher electrical conductivity than the background normal tissues.

title: Time-multiplexed two-channel capacitive radiofrequency XXXX with nanoparticle mediation.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['hyperthermia']

answer: @entity221 :: (MESH:D005334,Disease) :: ['hyperthermia']


abstract: BACKGROUND: The prevalence of brick tea-type @entity3296 is high in Tibet because of the habit of drinking brick tea in this region. Brick tea-type @entity3296 has become an urgent public health problem in China. METHODS: A cross-sectional survey was conducted to investigate prevalence of brick tea-type @entity3296 in all districts of Tibet using a stratified cluster sampling method. @entity3296 in @entity1 aged 8-12 years and @entity922 in adults were diagnosed according to the national criteria. A total of 423 @entity1 and 1320 adults participated in the study. Samples of drinking water, brick tea, brick tea infusion (or buttered tea), and urine were collected and measured for @entity1388 concentrations by the @entity1388 ion selective electrode method. RESULTS: The @entity1388 level in all but one of the brick tea samples was above the national standard. The average daily @entity1388 intake from drinking brick tea in all seven districts in Tibet was much higher than the national standard. The prevalence of dental @entity3296 was 33.57%, and the prevalence of @entity922 was 46.06%. The average daily @entity1388 intake from drinking brick tea (r = 0.292, P < 0.05), urine @entity1388 concentrations in @entity1 (r = 0.134, P < 0.05), urine @entity1388 concentrations in adults (r = 0.162, P < 0.05), and altitude (r = 0.276, P < 0.05) were positively correlated with the prevalence of brick tea-type @entity3296 . Herdsmen had the highest @entity1388 exposure and the most severe @entity1141 . CONCLUSIONS: Brick tea-type @entity3296 in Tibet is more serious than in other parts of China. The altitude and occupational factors are important risk factors for brick tea-type @entity3296 .

title: Prevalence of Brick Tea-Type XXXX in the Tibet Autonomous Region.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity3296 :: ('MESH:D009050', 'Disease') :: ['fluorosis', 'Dental fluorosis']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['clinical skeletal fluorosis']

entities_list: @entity1388 :: ('MESH:D005459', 'Chemical') :: ['fluoride']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['skeletal fluorosis']

answer: @entity3296 :: (MESH:D009050,Disease) :: ['Fluorosis']


abstract: AIMS: In 2011, we demonstrated that an individualized health management system employing advanced medical information technology, designated ubiquitous (u)-healthcare, was helpful in achieving glycemic control without @entity4053 in @entity1 with @entity6 . Following this, we generated a new multidisciplinary u-healthcare system by upgrading our clinical decision support system (CDSS) rule engine and integrating a physical activity-monitoring device and dietary feedback into a comprehensive package. METHODS: In a randomized, controlled clinical trial, @entity1 with @entity164 2 @entity6 aged over 60  years were assigned randomly to a self-monitored blood @entity413 (SMBG) group (N  =  50) or u-healthcare group (N  =  50) for 6  months. The primary endpoint was the proportion of @entity1 achieving glycated hemoglobin (HbA1c) <7  % without @entity4053 . Changes in body composition and lipid profiles were also investigated. The u-healthcare group was educated to use a specially designed glucometer and an activity monitor that automatically transferred test results to a hospital-based server. An automated CDSS rule engine generated and sent @entity1 -specific messages about @entity413 , diet, and physical activity to their mobile phones and a Web site. RESULTS: After 6  months of follow-up, the HbA1c level was significantly decreased in the u-healthcare group [8.0      0.7  % (64.2      8.8  mmol/mol) to 7.3      0.9  % (56.7      9.9  mmol/mol)] compared with the SMBG group [8.1      0.8  % (64.9      9.1  mmol/mol) to 7.9      1.2  % (63.2      12.3  mmol/mol)] (P  <  0.01). The proportion of @entity1 with @entity4051 c  <  7  % without @entity4053 was greater in the u-healthcare group (26  %) than in the SMBG group (12  %; P  <  0.05). Body fat mass decreased and lipid profiles improved in the u-healthcare group but not in the SMBG group. CONCLUSION: This u-healthcare service provided effective management for older @entity1 with @entity164 2 @entity6 (ClinicalTrial.Gov: NCT01137058).

title: Multifactorial intervention in @entity6 care using real-time monitoring and tailored feedback in XXXX 2 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity164 :: (MESH:D017827,Disease) :: ['type']


abstract: AIMS: In 2011, we demonstrated that an individualized health management system employing advanced medical information technology, designated ubiquitous (u)-healthcare, was helpful in achieving glycemic control without @entity4053 in @entity1 with @entity6 . Following this, we generated a new multidisciplinary u-healthcare system by upgrading our clinical decision support system (CDSS) rule engine and integrating a physical activity-monitoring device and dietary feedback into a comprehensive package. METHODS: In a randomized, controlled clinical trial, @entity1 with @entity164 2 @entity6 aged over 60  years were assigned randomly to a self-monitored blood @entity413 (SMBG) group (N  =  50) or u-healthcare group (N  =  50) for 6  months. The primary endpoint was the proportion of @entity1 achieving glycated hemoglobin (HbA1c) <7  % without @entity4053 . Changes in body composition and lipid profiles were also investigated. The u-healthcare group was educated to use a specially designed glucometer and an activity monitor that automatically transferred test results to a hospital-based server. An automated CDSS rule engine generated and sent @entity1 -specific messages about @entity413 , diet, and physical activity to their mobile phones and a Web site. RESULTS: After 6  months of follow-up, the HbA1c level was significantly decreased in the u-healthcare group [8.0      0.7  % (64.2      8.8  mmol/mol) to 7.3      0.9  % (56.7      9.9  mmol/mol)] compared with the SMBG group [8.1      0.8  % (64.9      9.1  mmol/mol) to 7.9      1.2  % (63.2      12.3  mmol/mol)] (P  <  0.01). The proportion of @entity1 with @entity4051 c  <  7  % without @entity4053 was greater in the u-healthcare group (26  %) than in the SMBG group (12  %; P  <  0.05). Body fat mass decreased and lipid profiles improved in the u-healthcare group but not in the SMBG group. CONCLUSION: This u-healthcare service provided effective management for older @entity1 with @entity164 2 @entity6 (ClinicalTrial.Gov: NCT01137058).

title: Multifactorial intervention in XXXX care using real-time monitoring and tailored feedback in @entity164 2 @entity6 .

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: AIMS: In 2011, we demonstrated that an individualized health management system employing advanced medical information technology, designated ubiquitous (u)-healthcare, was helpful in achieving glycemic control without @entity4053 in @entity1 with @entity6 . Following this, we generated a new multidisciplinary u-healthcare system by upgrading our clinical decision support system (CDSS) rule engine and integrating a physical activity-monitoring device and dietary feedback into a comprehensive package. METHODS: In a randomized, controlled clinical trial, @entity1 with @entity164 2 @entity6 aged over 60  years were assigned randomly to a self-monitored blood @entity413 (SMBG) group (N  =  50) or u-healthcare group (N  =  50) for 6  months. The primary endpoint was the proportion of @entity1 achieving glycated hemoglobin (HbA1c) <7  % without @entity4053 . Changes in body composition and lipid profiles were also investigated. The u-healthcare group was educated to use a specially designed glucometer and an activity monitor that automatically transferred test results to a hospital-based server. An automated CDSS rule engine generated and sent @entity1 -specific messages about @entity413 , diet, and physical activity to their mobile phones and a Web site. RESULTS: After 6  months of follow-up, the HbA1c level was significantly decreased in the u-healthcare group [8.0      0.7  % (64.2      8.8  mmol/mol) to 7.3      0.9  % (56.7      9.9  mmol/mol)] compared with the SMBG group [8.1      0.8  % (64.9      9.1  mmol/mol) to 7.9      1.2  % (63.2      12.3  mmol/mol)] (P  <  0.01). The proportion of @entity1 with @entity4051 c  <  7  % without @entity4053 was greater in the u-healthcare group (26  %) than in the SMBG group (12  %; P  <  0.05). Body fat mass decreased and lipid profiles improved in the u-healthcare group but not in the SMBG group. CONCLUSION: This u-healthcare service provided effective management for older @entity1 with @entity164 2 @entity6 (ClinicalTrial.Gov: NCT01137058).

title: Multifactorial intervention in @entity6 care using real-time monitoring and tailored feedback in @entity164 2 XXXX .

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: OBJECTIVES: evaluation of a centralised collection of clinical data (Service) within @entity5 screening programmes in Piedmont based on a hub_spoke model and its impact on process indicators. DESIGN: assessment of an organisational intervention, through a non-controlled pre-post design. SETTING AND @entity1 : organised screening programmes within the Piedmont Region, divided into 9 departments. MAIN OUTCOME MEASURES: clinical data (extracted from medical charts for mammography screening and from excision histology reports for cervical screening) obtained through the Service were quantified and their completeness was assessed. The Service impact on the detection rate (DR) was evaluated, comparing the DR pre- (2005-2008) and post-Service (2009- 2012) within breast screening; the DR was computed through histological diagnosis made during colposcopy (pre-Service method) or through the worst diagnosis between the latter and that reported from excision histology (post-Service method) within cervical screening (data available for department 1, year 2013). Some hints on @entity1 resources employed in pre- and post-Service periods were reported. RESULTS: within mammography screening, the Service obtained 53.1% of extra-department medical charts and 45.8% of extra-region ones; the percentage of missing diagnoses changed from 5.5% (pre- Service) to 3.7% (post-Service). The age standardised DR for @entity5 in the post-Service period is 1.3 times the DR of the pre-Service period per 1,000 screening tests. Within cervical screening, 51.7% of histological reports was recorded. Crude DR for high-grade lesions changed from 3.9 (pre-Service) to 4.7 (post-Service) per 1,000 screened @entity1 . The system centralisation did not imply an increase in the dedicated personnel. CONCLUSION: the Service is an operational core which coordinates the collection of clinical data, impacting on process indicators without an increase in @entity1 resources at departmental level.

title: [Introduction of a centralised system (Service) for collecting clinical data in XXXX screening programmes in Piedmont (Northern Italy): a pre-post assessment of a hub_spoke model].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumours', 'cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'human', 'PARTICIPANTS']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: INTRODUCTION: We report a case of @entity1466 that was initially diagnosed as an ectopic pregnancy with a concomitant invasive @entity1544 . CASE PRESENTATION: A 35-year-old @entity1 , gravida 4 para 3, presented to an outside hospital with @entity3556 and @entity2371 . Diagnosed with ectopic pregnancy, the @entity1 was brought to the operating room. Examination under anesthesia revealed a fungating cervical mass. A biopsy was obtained, but dilatation and curettage was deemed too dangerous. The @entity1 was empirically treated with @entity1499 . The gynecology team at Einstein was contacted when the cervical biopsy returned as poorly differentiated @entity957 . The @entity1 was taken to the operating room by a gynecologic oncologist for a staging procedure, further cervical biopsy, and a failed attempt at dilatation and curettage. Pathology showed invasive poorly differentiated @entity189 with focal areas of squamous differentiation, extensive @entity1066 , @entity39 , and @entity548 . The @entity1 began chemotherapy with plans for radiation therapy. The b @entity1 chorionic gonadotropin (b-hCG) levels continued to plateau. The case was brought to the @entity5 board and the potential for a @entity1466 was then raised. The slides were reviewed and restained. With this information the diagnosis of @entity1466 was made. The chemotherapy was adjusted and the b-hCG began to fall. DISCUSSION: The case demonstrates the importance of trending b-hCG levels in the absence of a pathology report confirming products of conception. This case also demonstrates the importance of interdisciplinary discussion and review of cases to provide quality care.

title: A Case of XXXX Initially Diagnosed as an Ectopic Pregnancy With a Concomitant @entity1544 [199].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'human', 'patient']

entities_list: @entity3556 :: ('MESH:D014592', 'Disease') :: ['vaginal bleeding']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity1466 :: ('MESH:D002822', 'Disease') :: ['choriocarcinoma']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['invasive squamous cell carcinoma of the cervix']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['pelvic pain']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell cervical cancer']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity1466 :: (MESH:D002822,Disease) :: ['Choriocarcinoma']


abstract: INTRODUCTION: We report a case of @entity1466 that was initially diagnosed as an ectopic pregnancy with a concomitant invasive @entity1544 . CASE PRESENTATION: A 35-year-old @entity1 , gravida 4 para 3, presented to an outside hospital with @entity3556 and @entity2371 . Diagnosed with ectopic pregnancy, the @entity1 was brought to the operating room. Examination under anesthesia revealed a fungating cervical mass. A biopsy was obtained, but dilatation and curettage was deemed too dangerous. The @entity1 was empirically treated with @entity1499 . The gynecology team at Einstein was contacted when the cervical biopsy returned as poorly differentiated @entity957 . The @entity1 was taken to the operating room by a gynecologic oncologist for a staging procedure, further cervical biopsy, and a failed attempt at dilatation and curettage. Pathology showed invasive poorly differentiated @entity189 with focal areas of squamous differentiation, extensive @entity1066 , @entity39 , and @entity548 . The @entity1 began chemotherapy with plans for radiation therapy. The b @entity1 chorionic gonadotropin (b-hCG) levels continued to plateau. The case was brought to the @entity5 board and the potential for a @entity1466 was then raised. The slides were reviewed and restained. With this information the diagnosis of @entity1466 was made. The chemotherapy was adjusted and the b-hCG began to fall. DISCUSSION: The case demonstrates the importance of trending b-hCG levels in the absence of a pathology report confirming products of conception. This case also demonstrates the importance of interdisciplinary discussion and review of cases to provide quality care.

title: A Case of @entity1466 Initially Diagnosed as an Ectopic Pregnancy With a Concomitant XXXX [199].

answer: @entity1544 :: (MESH:D018307,Disease) :: ['Invasive Squamous Cell Cervical Cancer']


abstract: 1. @entity4605 nucleotide transhydrogenase from @entity1486 was purified with a scaled-up procedure. In a typical purification 500 ml cell-free extract from 200 g cells is loaded on an Ado-2',5'-P2--Sepharose 4B affinity column (20 ml bed volume). After washing, the enzyme is desorbed with @entity50047 at neutral pH and further purified by Sephadex G-200 gel chromatography. The enzyme (10--12 mg) is obtained in 40--60% yield and is homogeneous as judged by @entity2975 gel electrophoresis in the presence of @entity214 . 2. The homogeneity of the purified enzyme is also apparent from electron microscopy studies, where the enzyme appears as a polydisperse set of polymers without contaminating structures and from fluorescence lifetime studies by the method of single-photon counting. The @entity1785 fluorescence appears to decay with a single lifetime tau = 2.5 ns. The polymeric nature of transhydrogenase can be aptly demonstrated by density gradient centrifugation in the presence of KBr. After centrifuging for 50 h at 160 000 X g and 10 degrees C the enzyme is concentrated in a narrow fluorescent band with buoyant density rho b = 1.305 g cm-3. 3. The arrangement of subunits in the transhydrogenase polymer has been derived from optical diffraction studies of electron micrographs. The polymers are built up from a linear assembly of tetramers. Four subunits are placed in a rhomb with sides of 13.5 mm and an angle of 45 degrees (135 degrees) between the sides. A second tetramer is located staggered on top of the first one. Since a variety of other studies have indicated that the polymers dissociate into octamers under alkaline conditions [Voordouw, G. et al. (1979 Eur. J. Biochem. 98,447--454] we conclude that this smallest functional unit is build up from two tetramers.

title: Pyridine nucleotide transhydrogenase from XXXX . Improved purification, physical properties and subunit arrangement in purified polymers.

entities_list: @entity4605 :: ('MESH:C023666', 'Chemical') :: ['Pyridine']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity1486 :: ('354', 'Species') :: ['Azotobacter vinelandii']

entities_list: @entity214 :: ('CHEBI:8984', 'Chemical') :: ['sodium dodecyl sulphate']

answer: @entity1486 :: (354,Species) :: ['Azotobacter vinelandii']


abstract: INTRODUCTION: @entity1118 is common with a prevalence of 15% among adult @entity1 in the United States. We sought to identify key presenting characteristics for @entity169 in @entity1 as a primary source of chronic @entity2371 . METHODS: We performed a retrospective cohort study from March 2009 to February 2014 of females with chronic @entity2371 referred by their gynecologist to a surgeon specializing in @entity547 . Standardized preoperative questionnaires and an examination targeting @entity169 were completed. @entity1 with a high heightened suspicion for groin @entity547 underwent surgical exploration and repair along with concomitant gynecologic procedures if indicated. RESULTS: Of the 38 @entity1 referred and evaluated, 19 (50%) were considered candidates for groin exploration. Sixteen of the 18 (88.9%) @entity1 who underwent surgical exploration were confirmed to have @entity169 , which were subsequently repaired. No single preoperative historical factor or subjective @entity158 complaint was predictive of a @entity547 . Point tenderness at the internal inguinal ring was the only significant finding among those with proven @entity547 (P=.009, odds ratio 25). Among those who underwent repair, preoperative @entity158 scores significantly decreased from 7.2 of 10 to 3.1 of 10 within 2 weeks of surgery (P<.001). CONCLUSION: @entity169 represent a known cause of chronic @entity2371 in @entity1 . Tenderness at the internal inguinal ring is strongly associated with the diagnosis of occult @entity169 in such @entity1 . With such a dramatic and rapid improvement in @entity158 that appears to be long-lasting, collaboration between gynecologists and @entity547 specialists may improve care for @entity1 with chronic @entity2371 .

title: Inguinal @entity547 as a Cause of XXXX : A Key Sign to Make the Diagnosis [215].

entities_list: @entity547 :: ('MESH:D006547', 'Disease') :: ['hernia', 'hernias']

entities_list: @entity169 :: ('MESH:D006552', 'Disease') :: ['inguinal hernias', 'Inguinal hernias', 'inguinal hernia']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['Chronic pelvic pain']

answer: @entity1118 :: (MESH:D059350,Disease) :: ['Chronic Pelvic Pain']


abstract: INTRODUCTION: @entity1118 is common with a prevalence of 15% among adult @entity1 in the United States. We sought to identify key presenting characteristics for @entity169 in @entity1 as a primary source of chronic @entity2371 . METHODS: We performed a retrospective cohort study from March 2009 to February 2014 of females with chronic @entity2371 referred by their gynecologist to a surgeon specializing in @entity547 . Standardized preoperative questionnaires and an examination targeting @entity169 were completed. @entity1 with a high heightened suspicion for groin @entity547 underwent surgical exploration and repair along with concomitant gynecologic procedures if indicated. RESULTS: Of the 38 @entity1 referred and evaluated, 19 (50%) were considered candidates for groin exploration. Sixteen of the 18 (88.9%) @entity1 who underwent surgical exploration were confirmed to have @entity169 , which were subsequently repaired. No single preoperative historical factor or subjective @entity158 complaint was predictive of a @entity547 . Point tenderness at the internal inguinal ring was the only significant finding among those with proven @entity547 (P=.009, odds ratio 25). Among those who underwent repair, preoperative @entity158 scores significantly decreased from 7.2 of 10 to 3.1 of 10 within 2 weeks of surgery (P<.001). CONCLUSION: @entity169 represent a known cause of chronic @entity2371 in @entity1 . Tenderness at the internal inguinal ring is strongly associated with the diagnosis of occult @entity169 in such @entity1 . With such a dramatic and rapid improvement in @entity158 that appears to be long-lasting, collaboration between gynecologists and @entity547 specialists may improve care for @entity1 with chronic @entity2371 .

title: Inguinal XXXX as a Cause of @entity1118 : A Key Sign to Make the Diagnosis [215].

answer: @entity547 :: (MESH:D006547,Disease) :: ['Hernia']


abstract: UNASSIGNED: Data regarding availability of @entity5015 ( @entity5014 ) and its impact on the stabilization, transport, critical care course, and surgical outcome of @entity1 with ductal-dependent @entity299 in the current pediatric healthcare environment are unknown. We sought to determine the proportion of hospitals in Texas that stock @entity5014 and to investigate associations between @entity5014 availability and clinical outcomes. All birth institutions listed with the Texas Department of Health and @entity1 Services were contacted to determine @entity5014 availability as of 2011. Outcomes of all @entity1 admitted to our institution from 2007 to 2012 who received @entity5014 for @entity75 were evaluated. @entity5014 was stocked in 50  % (n  =  139) of hospitals that performed deliveries in Texas in 2011 representing 79.1  % (303, 481) of births. Hospitals that did not stock @entity5014 had less annual births and were located a further distance from a center that provided pediatric cardiac surgical services. @entity1 born at a hospital that did not stock @entity5014 had significantly greater serum @entity880 and @entity1011 (p  =  0.002) and serum @entity880 on admission (p  <  0.001). The @entity5014 availability was not associated with hospital length of stay, postoperative length of stay, or mortality. When stratifying in TGA and @entity1699 subgroups, lack of @entity5014 availability remained associated with higher @entity1011 , higher @entity880 , lower @entity413 , and lower pH. @entity5014 is not universally available in all healthcare institutions providing obstetrical services. Lack of availability of @entity5014 at an outlying hospital was associated with increased morbidity, but was not associated with mortality or length of stay.

title: Prostaglandin Availability and Association with Outcomes for @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'infants', 'Human']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['ductal-dependent lesions']

entities_list: @entity5015 :: ('MESH:D000527', 'Chemical') :: ['prostaglandin E1']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity299 :: (MESH:D006331,Disease) :: ['Congenital Heart Disease']


abstract: UNASSIGNED: Data regarding availability of @entity5015 ( @entity5014 ) and its impact on the stabilization, transport, critical care course, and surgical outcome of @entity1 with ductal-dependent @entity299 in the current pediatric healthcare environment are unknown. We sought to determine the proportion of hospitals in Texas that stock @entity5014 and to investigate associations between @entity5014 availability and clinical outcomes. All birth institutions listed with the Texas Department of Health and @entity1 Services were contacted to determine @entity5014 availability as of 2011. Outcomes of all @entity1 admitted to our institution from 2007 to 2012 who received @entity5014 for @entity75 were evaluated. @entity5014 was stocked in 50  % (n  =  139) of hospitals that performed deliveries in Texas in 2011 representing 79.1  % (303, 481) of births. Hospitals that did not stock @entity5014 had less annual births and were located a further distance from a center that provided pediatric cardiac surgical services. @entity1 born at a hospital that did not stock @entity5014 had significantly greater serum @entity880 and @entity1011 (p  =  0.002) and serum @entity880 on admission (p  <  0.001). The @entity5014 availability was not associated with hospital length of stay, postoperative length of stay, or mortality. When stratifying in TGA and @entity1699 subgroups, lack of @entity5014 availability remained associated with higher @entity1011 , higher @entity880 , lower @entity413 , and lower pH. @entity5014 is not universally available in all healthcare institutions providing obstetrical services. Lack of availability of @entity5014 at an outlying hospital was associated with increased morbidity, but was not associated with mortality or length of stay.

title: Prostaglandin Availability and Association with Outcomes for XXXX with @entity299 .

answer: @entity1 :: (9606,Species) :: ['Infants']


abstract: UNASSIGNED: @entity311 is considered to be one of the most @entity66 in the world. Severity of the disease between males and females is very important in clinical research areas. In this study, we investigated the impact of sex differences in brain response to @entity281 with @entity2637 . Male and female C57Bl/6 @entity19 were infected with @entity2637 -infected erythrocytes. The @entity281 induced a significant change in weight loss in males (-7.2  %        0.5) than females (-4.9  %        0.6). The maximum @entity5895 reached about 15  % at day 9 postinfection. Also, @entity2637 @entity281 caused histopathological changes in the brain of @entity19 . These changes were in the form of @entity32 , @entity548 , and structural changes in Purkinje cells. In addition, @entity2637 was able to induce a marked oxidative damage in @entity19 brain. The @entity281 induced a significant increase in male brain @entity2041 than females while the brain catalase level was significantly increased in infected females than infected males. Moreover, the change in brain neurotransmitters, @entity935 , @entity1425 , @entity1063 , and @entity750 , was more in infected males than infected females. At the molecular level, @entity2637 was able to induce upregulations of Adam23, Cabp1, Cacnb4, Glrb, and Vdac3-mRNA in the brain of @entity19 . These genes were significantly upregulated in infected males than in infected females. In general, @entity2637 could induce structural, biochemical, and molecular alterations in @entity19 brain. Severity of these alterations was different according to sex of @entity19 .

title: Impact of sex differences in brain response to @entity281 with XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['prevalent diseases']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity5895 :: ('MESH:D018512', 'Disease') :: ['parasitemia']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

entities_list: @entity1063 :: ('MESH:D009638', 'Chemical') :: ['norepinephrine']

entities_list: @entity2637 :: ('5821', 'Species') :: ['Plasmodium berghei', 'P. berghei']

answer: @entity2637 :: (5821,Species) :: ['Plasmodium berghei']


abstract: UNASSIGNED: @entity311 is considered to be one of the most @entity66 in the world. Severity of the disease between males and females is very important in clinical research areas. In this study, we investigated the impact of sex differences in brain response to @entity281 with @entity2637 . Male and female C57Bl/6 @entity19 were infected with @entity2637 -infected erythrocytes. The @entity281 induced a significant change in weight loss in males (-7.2  %        0.5) than females (-4.9  %        0.6). The maximum @entity5895 reached about 15  % at day 9 postinfection. Also, @entity2637 @entity281 caused histopathological changes in the brain of @entity19 . These changes were in the form of @entity32 , @entity548 , and structural changes in Purkinje cells. In addition, @entity2637 was able to induce a marked oxidative damage in @entity19 brain. The @entity281 induced a significant increase in male brain @entity2041 than females while the brain catalase level was significantly increased in infected females than infected males. Moreover, the change in brain neurotransmitters, @entity935 , @entity1425 , @entity1063 , and @entity750 , was more in infected males than infected females. At the molecular level, @entity2637 was able to induce upregulations of Adam23, Cabp1, Cacnb4, Glrb, and Vdac3-mRNA in the brain of @entity19 . These genes were significantly upregulated in infected males than in infected females. In general, @entity2637 could induce structural, biochemical, and molecular alterations in @entity19 brain. Severity of these alterations was different according to sex of @entity19 .

title: Impact of sex differences in brain response to XXXX with @entity2637 .

answer: @entity281 :: (MESH:D007239,Disease) :: ['infection']


abstract: PURPOSE: @entity11 ( @entity11 ) are rare @entity5 that occur in @entity1 aged between 1 and 24  months. The @entity5 in general has a favorable prognosis after surgical resection. There are no treatment algorithms, however, for @entity1 with multiple intracranial and intraspinal presentations. CASE REPORT: In an 11-month-old @entity1 with a history of nystagmus, magnetic resonance imaging (MRI) demonstrated contrast-enhancing lesions in the suprasellar region, the cerebellar vermis, and the spinal axis. The @entity5 in the cerebellar vermis was removed via a suboccipital midline approach. The histological examination revealed a @entity7668 ( @entity7668 ) WHO grade I. Postoperatively, it was decided to adopt a wait-and-see strategy. Further development, up to 16  months after surgery, was unremarkable. Follow-up MRI showed no recurrence of the @entity6804 , mild progress of the @entity5 , and significant regression of the @entity5 . CONCLUSION: @entity7668 is a rare mostly benign @entity1313 found in @entity1 . The final diagnosis always relies on histology. Surgical resection is the recommended therapy for symptomatic @entity5 ; however, more experience is needed to develop treatment recommendations for multiple-site @entity5 .

title: XXXX with multiple intracranial and intraspinal localizations at presentation.

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patients', 'infants']

entities_list: @entity7668 :: ('MESH:C535945', 'Disease') :: ['desmoplastic infantile astrocytoma', 'DIA']

entities_list: @entity6804 :: ('MESH:D015192', 'Disease') :: ['posterior fossa tumor']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'spinal tumors', 'suprasellar tumor', 'tumors']

entities_list: @entity11 :: ('MESH:D005910', 'Disease') :: ['Desmoplastic infantile gliomas', 'DIG']

answer: @entity7668 :: (MESH:C535945,Disease) :: ['Desmoplastic infantile astrocytoma']


abstract: In the haploid genome of @entity1238 there are two genes coding for the r-protein @entity72032 . It is not known if they are located on the same chromosome. cDNA clones deriving from the transcripts of the two genes have been isolated from an oocyte messenger cDNA bank showing that they are both expressed. We have studied the structure of one of the @entity72032 genes by Electron Microscopy, restriction mapping and sequencing. An allelic form of the @entity72032 gene was also isolated. It contains a large deletion covering the 5' end region up to the middle of the third intron. The 5' end of the @entity1238 @entity72032 gene was compared to that of the corresponding gene in the closely related species @entity24799 and found to be highly conserved. The @entity72032 gene has multiple initiation sites, but the large majority of the transcripts start in the middle of a @entity7391 tract not preceded by a canonical TATA box as in other eukaryotic housekeeping genes. The @entity1238 L1 and @entity72032 genes have a common decanucleotide in the first exon in the same position with regard to the initiator ATG which just precedes the first intron. The decanucleotide shows homology with the @entity1238 18S rRNA.

title: Sequences coding for the ribosomal protein L14 in XXXX and @entity24799 ; homologies in the 5' untranslated region are shared with other r-protein mRNAs.

entities_list: @entity1238 :: ('8355', 'Species') :: ['Xenopus laevis', 'X. laevis']

entities_list: @entity7391 :: ('MESH:C030986', 'Chemical') :: ['pyrimidine']

answer: @entity1238 :: (8355,Species) :: ['Xenopus laevis']


abstract: In the haploid genome of @entity1238 there are two genes coding for the r-protein @entity72032 . It is not known if they are located on the same chromosome. cDNA clones deriving from the transcripts of the two genes have been isolated from an oocyte messenger cDNA bank showing that they are both expressed. We have studied the structure of one of the @entity72032 genes by Electron Microscopy, restriction mapping and sequencing. An allelic form of the @entity72032 gene was also isolated. It contains a large deletion covering the 5' end region up to the middle of the third intron. The 5' end of the @entity1238 @entity72032 gene was compared to that of the corresponding gene in the closely related species @entity24799 and found to be highly conserved. The @entity72032 gene has multiple initiation sites, but the large majority of the transcripts start in the middle of a @entity7391 tract not preceded by a canonical TATA box as in other eukaryotic housekeeping genes. The @entity1238 L1 and @entity72032 genes have a common decanucleotide in the first exon in the same position with regard to the initiator ATG which just precedes the first intron. The decanucleotide shows homology with the @entity1238 18S rRNA.

title: Sequences coding for the ribosomal protein L14 in @entity1238 and XXXX ; homologies in the 5' untranslated region are shared with other r-protein mRNAs.

answer: @entity24799 :: (8364,Species) :: ['Xenopus tropicalis']


abstract: OBJECTIVE: @entity1150 ( @entity1150 ) is a life-threatening and morbid pathology. This study aimed to investigate the efficacy of an early thrombolysis procedure using a rotator thrombolysis device. METHODS: Sixty-seven @entity1 with acute proximal @entity1150 were enrolled in the study. @entity1 ' data were recorded retrospectively. Initially, an infrarenal retrievable vena cava filter was placed through the femoral vein. Then, a rotator thrombolysis device and a thrombolytic agent injection were applied to the occluded segments of the deep veins by puncturing the popliteal vein. RESULTS: The identified reasons were @entity130 (43.3%), pregnancy (20.9%), undiagnosed (11.9%), major surgical operation (10.5%), immobilization (7.5%), and @entity5 (5.9%). Immediate total recanalization was conducted in all @entity1 , and the leg diameters returned to normal ranges in the early postoperative period. Hospital mortality or severe complications were not detected. CONCLUSION: New thrombolytic devices seem to reduce in-hospital mortality risks and may potentially decrease post-thrombotic morbidity.

title: Pharmacomechanical thrombolysis with a rotator thrombolysis device in iliofemoral XXXX .

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['Deep venous thrombosis', 'DVT']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep venous thrombosis']


abstract: Allergen immunotherapy results in protection against allergen challenge and in the production of allergen specific antibodies. We investigated the reaction to @entity5157 sting exposure and its relationship to the subclass of IgG-antibodies produced. 23 @entity1 who had a history of @entity56 to @entity5157 stings were given 2-5 years courses of venom immunotherapy. 19 individuals tolerated a sting challenge 1, 2, and 3 years after the start of treatment, and after immunotherapy was discontinued. Four @entity1 with persisting systemic reactions and 6 @entity5157 keepers served as controls. All detectable IgG-antibodies were restricted to subclass 1 and 4. In successfully treated @entity1 the mean rise of IgG-subclass was 273%, and of IgG4 703%, compared to pretreatment levels. IgG4-antibodies were maintained at high levels in protected individuals when immunotherapy was discontinued. On the contrary, in non-protected individuals low IgG4-levels were observed. Specific IgG4-antibodies most closely reflect clinical protection from stings provided by immunotherapy or a repeated antigenic stimulation.

title: [The key role of IgG4 subclass antibodies in the development of protection against XXXX to insect stings].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['systemic allergic reactions']

answer: @entity56 :: (MESH:D004342,Disease) :: ['allergic reactions']


abstract: A major challenge in @entity1907 ( @entity378 ) control is early and accurate diagnosis of sputum smear negative @entity1907 (SSN-PTB). The @entity1 with SSN-PTB have to wait for a longer period of time before receiving proper treatment than sputum smear positive @entity1907 (SSP-PTB) @entity1 due to delay in diagnosis. The purpose of this study is to discover potential serum protein biomarkers for SSN-PTB. Surface-enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF MS) combined with weak cation exchange (WCX) magnetic beads was used to screen serum samples from SSN-PTB @entity1 (N = 66), SSP-PTB @entity1 (N = 49), and healthy volunteers (N = 80). The serum protein profiles were analyzed with Biomarker Wizard system. A classification model was established using Biomarker Pattern Software (BPS). Fifty-eight protein peaks were identified to exhibit significant differences between SSN-PTB, SSP-PTB and healthy control groups (P < 0.05), among which 6 peaks were found to be down-regulated, while 10 peaks were up-regulated gradually in the healthy control, SSN-PTB, and SSP-PTB groups. Twenty-three discriminating m/z peaks were detected between SSN-PTB @entity1 and healthy controls (P < 0.01, Fold >=  1.5). The classification tree combined with three protein peaks (2747.0, 4480.0, and 9410.1 Da) could distinguish SSN-PTB @entity1 from healthy controls with a sensitivity of 83.33% and a specificity of 82.50%. Early diagnosis of SSN-PTB disease is critical in order to reduce morbidity and mortality associated with @entity378 . The study will help to clarify the role of differential proteins in the pathogenesis of @entity378 .

title: Comparative proteomic analysis of serum diagnosis patterns of sputum smear-positive XXXX based on magnetic bead separation and mass spectrometry analysis.

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis', 'pulmonary TB']

answer: @entity1907 :: (MESH:D014397,Disease) :: ['pulmonary tuberculosis']


abstract: BACKGROUND: The presence of @entity46 in the kidney is extremely rare. We report a case of @entity46 in @entity8 incidentally found in a malfunctioning kidney removed because of xanthogranulomatous @entity2885 . CASE PRESENTATION: A 53-year-old Chinese premenopausal @entity1 presented with intermittent right flank @entity158 for many years. Imaging studies revealed a contracted non-functioning right kidney and a @entity20597 . The contracted kidney was considered to have resulted from chronic @entity2885 . The abscess was drained. The @entity1 subsequently underwent a right nephrectomy. Histology revealed @entity8 in addition to xanthogranulomatous @entity2885 and a @entity20597 . No evidence of @entity46 was identified at the pelvic site. The @entity1 was symptom-free after operation. CONCLUSION: Endometriosis is a common benign condition in @entity1 of reproductive age that is characterized by the presence of endometrial glands and stroma outside the uterine cavity, which affects either genital or extragenital sites. Involvement of the urinary tract is rare. Among the urinary tract @entity46 , only a few cases involve the kidney. @entity8 is difficult to diagnose; a final diagnosis relies on the pathohistologic findings. Treatment involves hormonal manipulation or a hysterectomy with bilateral salpingo-oophorectomy. Whether a nephrectomy required depends on the level of renal function. Although extremely rare, renal @entity46 should be part of the differential diagnostic spectrum when a contracted, @entity8 is present. Early diagnosis might have prevented an unnecessary nephrectomy in cases of uncomplicated renal @entity46 .

title: Endometriosis in a kidney with focal xanthogranulomatous XXXX and a @entity20597 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['endometriosis of renal parenchyma', 'renal parenchyma', 'non-functioning kidney', 'Renal endometriosis']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['pyelonephritis']

entities_list: @entity20597 :: ('MESH:D010501', 'Disease') :: ['perinephric abscess']

answer: @entity2885 :: (MESH:D011704,Disease) :: ['pyelonephritis']


abstract: BACKGROUND: The presence of @entity46 in the kidney is extremely rare. We report a case of @entity46 in @entity8 incidentally found in a malfunctioning kidney removed because of xanthogranulomatous @entity2885 . CASE PRESENTATION: A 53-year-old Chinese premenopausal @entity1 presented with intermittent right flank @entity158 for many years. Imaging studies revealed a contracted non-functioning right kidney and a @entity20597 . The contracted kidney was considered to have resulted from chronic @entity2885 . The abscess was drained. The @entity1 subsequently underwent a right nephrectomy. Histology revealed @entity8 in addition to xanthogranulomatous @entity2885 and a @entity20597 . No evidence of @entity46 was identified at the pelvic site. The @entity1 was symptom-free after operation. CONCLUSION: Endometriosis is a common benign condition in @entity1 of reproductive age that is characterized by the presence of endometrial glands and stroma outside the uterine cavity, which affects either genital or extragenital sites. Involvement of the urinary tract is rare. Among the urinary tract @entity46 , only a few cases involve the kidney. @entity8 is difficult to diagnose; a final diagnosis relies on the pathohistologic findings. Treatment involves hormonal manipulation or a hysterectomy with bilateral salpingo-oophorectomy. Whether a nephrectomy required depends on the level of renal function. Although extremely rare, renal @entity46 should be part of the differential diagnostic spectrum when a contracted, @entity8 is present. Early diagnosis might have prevented an unnecessary nephrectomy in cases of uncomplicated renal @entity46 .

title: Endometriosis in a kidney with focal xanthogranulomatous @entity2885 and a XXXX .

answer: @entity20597 :: (MESH:D010501,Disease) :: ['perinephric abscess']


abstract: Recent data indicate that the prevalence and incidence of @entity302 are high among the elderly, many of whom will have concomitant neurodegenerative, cerebrovascular, or @entity5 . The aim of this study is to evaluate the clinical characteristics of elderly @entity1 with @entity302 in China. We retrospectively reviewed the clinical records of 104 outpatients over 50 years of age (average: 63.8 years). The results showed that in the total 104 outpatients, 53 @entity1 and 51 @entity1 were studied. Twenty-seven (26.0%) @entity1 had @entity3762 , and 15 (14.4%) @entity1 were considered cryptogenic. Sixty-two (59.6%) @entity1 had remote @entity302 . According to the known etiological factors, @entity66 (53.2%) is the most common underlying cause, followed by @entity542 (16.1%), primary or metastatic @entity5 (16.1%), and others (14.5%). The most common type of @entity410 in the group studied was partial @entity410 (51.9%), followed by generalized @entity410 (37.5%). Forty-three @entity1 (41.3%) were used combination medication and 61 @entity1 (58.7%) were used single medication. In conclusions, this study provides important data for clinical and research purposes in China. Further research is indicated to confirm the clinical findings of the elderly @entity1 with @entity302 by a larger epidemiological study.

title: Evaluation of clinical features of elderly XXXX in China.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'people', 'men']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplastic disease']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['craniocerebral trauma']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['symptomatic epilepsy', 'epilepsy']

entities_list: @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic epilepsy syndromes']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: @entity5249 is an uncommon disorder of postero-medial proximal tibial physis. Blount described infantile and adolescent types. This study aims to describe using femur, @entity20174 to treat infantile @entity5249 . From May 1992 to May 2005, 7 @entity1 of @entity5249 (3 males, 4 females) were included, whose age was range from 17 to 62 months. Femorotibial angle (FTA) was 31    6   (range from 27   to 41  ). Metaphyseal-diaphyseal angle (MDA) was 16    4   (range from 13   to 24  ). The femoral vara angle was 10    4   (range from 2   to 23  ). According to Langenskiold's classification, 3 @entity1 were in stage II, 7 @entity1 in stage III, and 2 @entity1 in stage IV. Five cases were affected bilateral and 2 unilaterally, treated by famur, @entity20174 , and a hip spica cast were used for 6 weeks after operation. Results indicated that all @entity1 were followed up 3 to 16 years. FTA, MDA and femur diaphysis were measured, FTA was 2    7  valgus (from 4   vara to 13   valgus). MDA was 1    2  valgus (range from 0   to 12  ). Femoral diaphyseal angle was 1    3  valgus (range from 3   vara to 7   valgus). Six @entity1 could walk without any knee @entity158 , except for 1 @entity1 with @entity74 feels his left genu uncomfortable after long time stand or work. His MDA was 12  , and FAT was -4  . In conclusion, femur, @entity20174 are useful for correction of @entity5249 . Recurrence and complication are less than those reported for @entity5249 .

title: Melt-metaphyseal and diphyseal osteotomy for correction of infantile XXXX : a long-term follow-up study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity20174 :: ('MESH:C565349', 'Disease') :: ['tibia and fibula osteotomies', 'tibia and fibula valgus osteotomies']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['bilateral disorder']

entities_list: @entity5249 :: ('MESH:C536237', 'Disease') :: ["Blount's disease"]

answer: @entity5249 :: (MESH:C536237,Disease) :: ['Blount's disease']


abstract: This study aims to explore the mechanism of immunosuppressants combined with cord blood (IS + CBI) for severe @entity2150 . Selecting 30 @entity1 with SAA and all treated with IS + @entity72033 (newly diagnosed group). 23 @entity1 who were treated effectively (effective group) while 7 cases were treated invalidly (invalid group). Another 20 healthy individuals were selected as control group. To detect the expression levels of @entity4155 , @entity13236 and other cytokines by ELISA method in each group. To detect the engraftment of cord blood stem cells by using short tandem repeat-polymerase chain reaction (STR-PCR) method. 1. @entity4155 , @entity13236 and other cytokines expressions in newly diagnosed group were significantly higher than in the control group. 2. After 6 months, the level in effective group was significantly lower than pretherapy (P < 0.05).The level in invalid group had no obvious difference than pretherapy. 3. After 1 month and 3 months of treatment, a small amount of engraftment was found in effective group. After 6 months, implant rejection was showed. No effective engraftment was observed in invalid group. 1. @entity4155 , @entity13236 cells in SAA @entity1 increased which might positively correlated with the progression of @entity5167 . During the treatment of IS + CBI, there is a bridging mechanism between the early stage of engraftment and the advanced stage of immunosuppressant adjustment. The first 3 months after treatment, it relies on the engraftment of cord blood stem cells to promote hematopoietic recovery and 3 months later, it relies on immunosuppressants to maintain normal hematopoietic function.

title: Mechanism of immunosuppressants combined with cord blood for severe XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2150 :: ('MESH:D000741', 'Disease') :: ['aplastic anemia']

answer: @entity2150 :: (MESH:D000741,Disease) :: ['aplastic anemia']


abstract: OBJECTIVE: To compare the efficacy of diffusion-weighted (DW) magnetic resonance (MR) imaging and Doppler ultrasonography (US) by using quantitative markers in acute unilateral obstruction due to @entity1290 . METHODS: This prospective study included 28 @entity1 with unilateral @entity1695 and 18 healthy control subjects. In Doppler US and DW MR imaging, resistive index (RI) and apparent diffusion coefficient (ADC) values were measured respectively. The results were compared in @entity1 and in control subjects. Paired samples test, two-tailed unpaired Student's t test and Spearman analysis were performed for statistical analysis. RESULTS: The mean RI in the 28 obstructed kidneys was significantly higher than the mean RI in unobstructed kidneys and in control subjects (P < 0.05). The ADC of obstructed kidneys in the cortex was significantly lower than the ADC of the contralateral unobstructed kidneys (P < 0.05). The ADC of unobstructed kidneys was significantly higher than the ADC of control subjects in the cortex (P < 0.05). RI and ADC values yielded no significant correlation. CONCLUSION: Doppler US and DW MR imaging provide accurate and noninvasive diagnosis, Doppler US may be preferred as it is a more practical technique compared to DW MR imaging in the evaluation of acute @entity1695 due to @entity1290 .

title: Diffusion-weighted MR imaging and Doppler ultrasonography in the evaluation of renal parenchyma in acute XXXX .

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['renal stones']

entities_list: @entity1695 :: ('MESH:D014517', 'Disease') :: ['ureteral obstruction']

answer: @entity1695 :: (MESH:D014517,Disease) :: ['ureteral obstruction']


abstract: Enzymatic modification of @entity581 by nucleotidyltransferases, acetyltransferases and/or phosphotransferases accounts for the majority of @entity5292 -resistant @entity3064 isolates. In this study, we investigated the relationship between @entity5292 resistance and the presence of @entity5292 -modifying enzymes in @entity3064 clinical isolate groups with different resistance profiles. Thirty-two clinical A. baumannii isolates were included in this study. @entity3064 isolates were divided into 4 groups according to results of susceptibility testing. The presence of genes encoding the following @entity5292 -modifying enzymes; aph (3')-V1, aph (3')-Ia, aac (3)-Ia, aac (3) IIa, aac (6')-Ih, aac (6')-Ib and ant (2')-Ia responsible for resistance was investigated by PCR in all strains. The acetyltransferase (aac (6')-Ib, aac (3)-Ia) and phosphotransferase (aph (3')-Ia) gene regions were identified in the first group, which comprised nine @entity2892 , @entity2889 , and @entity801 -resistant isolates. The acetyltransferase (aac (6')-Ib, aac (3)-Ia), phosphotransferase (aph (3')-VI) and nucleotidyltransferase (ant2-Ia) gene regions were identified in the second group, which was composed of nine @entity2892 -resistant, @entity2889 -resistant and @entity801 -sensitive isolates. The acetyltransferase (aac (3)-Ia) and phosphotransferase (aph (3')-Ia) regions were identified in the fourth group, which comprised eight @entity2892 -sensitive, @entity2889 -sensitive and @entity801 -resistant isolates. Modifying enzyme gene regions were not detected in the third group, which was composed of six @entity2892 , @entity2889 and @entity801 -sensitive isolates. Our data are consistent with previous reports, with the exception of four isolates. Both acetyltransferases and phosphotransferases were widespread in A. baumannii clinical isolates in our study. However, the presence of the enzyme alone is insufficient to explain the resistance rates. Therefore, the association between the development of resistance and the presence of the enzyme and other components should be investigated further.

title: Modifying enzymes related @entity5292 : analyses of resistant XXXX isolates.

entities_list: @entity801 :: ('MESH:D005839', 'Chemical') :: ['gentamicin']

entities_list: @entity2892 :: ('MESH:D015378', 'Chemical') :: ['imipenem']

entities_list: @entity2889 :: ('MESH:C059500', 'Chemical') :: ['meropenem']

entities_list: @entity5292 :: ('D000617', 'Chemical') :: ['aminoglycoside']

entities_list: @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides']

entities_list: @entity3064 :: ('470', 'Species') :: ['Acinetobacter', 'Acinetobacter baumannii']

answer: @entity3064 :: (470,Species) :: ['Acinetobacter']


abstract: Enzymatic modification of @entity581 by nucleotidyltransferases, acetyltransferases and/or phosphotransferases accounts for the majority of @entity5292 -resistant @entity3064 isolates. In this study, we investigated the relationship between @entity5292 resistance and the presence of @entity5292 -modifying enzymes in @entity3064 clinical isolate groups with different resistance profiles. Thirty-two clinical A. baumannii isolates were included in this study. @entity3064 isolates were divided into 4 groups according to results of susceptibility testing. The presence of genes encoding the following @entity5292 -modifying enzymes; aph (3')-V1, aph (3')-Ia, aac (3)-Ia, aac (3) IIa, aac (6')-Ih, aac (6')-Ib and ant (2')-Ia responsible for resistance was investigated by PCR in all strains. The acetyltransferase (aac (6')-Ib, aac (3)-Ia) and phosphotransferase (aph (3')-Ia) gene regions were identified in the first group, which comprised nine @entity2892 , @entity2889 , and @entity801 -resistant isolates. The acetyltransferase (aac (6')-Ib, aac (3)-Ia), phosphotransferase (aph (3')-VI) and nucleotidyltransferase (ant2-Ia) gene regions were identified in the second group, which was composed of nine @entity2892 -resistant, @entity2889 -resistant and @entity801 -sensitive isolates. The acetyltransferase (aac (3)-Ia) and phosphotransferase (aph (3')-Ia) regions were identified in the fourth group, which comprised eight @entity2892 -sensitive, @entity2889 -sensitive and @entity801 -resistant isolates. Modifying enzyme gene regions were not detected in the third group, which was composed of six @entity2892 , @entity2889 and @entity801 -sensitive isolates. Our data are consistent with previous reports, with the exception of four isolates. Both acetyltransferases and phosphotransferases were widespread in A. baumannii clinical isolates in our study. However, the presence of the enzyme alone is insufficient to explain the resistance rates. Therefore, the association between the development of resistance and the presence of the enzyme and other components should be investigated further.

title: Modifying enzymes related XXXX : analyses of resistant @entity3064 isolates.

answer: @entity5292 :: (D000617,Chemical) :: ['aminoglycoside']


abstract: This case report describes the symptoms and clinical course of a 35-year-old female @entity1 who was diagnosed with a temporo-sphenoidal encephalocele. It is characterized by herniation of cerebral tissue of the temporal lobe through a defect of the skull base localized in the middle fossa. At the time of first presentation the @entity1 complained about recurrent nasal discharge of clear fluid which had begun some weeks earlier. She also reported that three months earlier she had for the first time suffered from a generalized @entity410 . In a first therapeutic attempt an endoscopic endonasal approach to the sphenoid sinus was performed. An attempt to randomly seal the suspicious area failed. After frontotemporal craniotomy, it was possible to localize the encephalocele and the underlying bone defect. The herniated brain tissue was resected and the dural defect was closed with fascia of the temporalis muscle. In summary, the combination of recurrent @entity5254 and a first-time @entity410 should alert specialists of otolaryngology, neurology and neurosurgery of a temporo-sphenoidal encephalocele as a possible cause. Treatment is likely to require a neurosurgical approach.

title: @entity5254 and XXXX caused by temporo-sphenoidal encephalocele.

entities_list: @entity5254 :: ('MESH:D002559', 'Disease') :: ['rhinorrhea']

answer: @entity410 :: (MESH:D012640,Disease) :: ['seizure']


abstract: This case report describes the symptoms and clinical course of a 35-year-old female @entity1 who was diagnosed with a temporo-sphenoidal encephalocele. It is characterized by herniation of cerebral tissue of the temporal lobe through a defect of the skull base localized in the middle fossa. At the time of first presentation the @entity1 complained about recurrent nasal discharge of clear fluid which had begun some weeks earlier. She also reported that three months earlier she had for the first time suffered from a generalized @entity410 . In a first therapeutic attempt an endoscopic endonasal approach to the sphenoid sinus was performed. An attempt to randomly seal the suspicious area failed. After frontotemporal craniotomy, it was possible to localize the encephalocele and the underlying bone defect. The herniated brain tissue was resected and the dural defect was closed with fascia of the temporalis muscle. In summary, the combination of recurrent @entity5254 and a first-time @entity410 should alert specialists of otolaryngology, neurology and neurosurgery of a temporo-sphenoidal encephalocele as a possible cause. Treatment is likely to require a neurosurgical approach.

title: XXXX and @entity410 caused by temporo-sphenoidal encephalocele.

answer: @entity5254 :: (MESH:D002559,Disease) :: ['Cerebrospinal fluid rhinorrhea']


abstract: UNASSIGNED: @entity40350 is a principal motivator of @entity1 molestation, incurring great emotional and financial burdens on victims and society. Even among pedophiles who never commit any offense, the condition requires lifelong suppression and control. Previous comparison using voxel-based morphometry (VBM) of MR images from a large sample of pedophiles and controls revealed group differences in white matter. The present study therefore sought to verify and characterize white matter involvement using diffusion tensor imaging (DTI), which better captures the microstructure of white matter than does VBM. Pedophilic sex offenders (n  =  24) were compared with healthy, age-matched controls with no criminal record and no indication of @entity40350 (n  =  32). White matter microstructure was analyzed with Tract-Based Spatial Statistics, and the trajectories of implicated fiber bundles were identified by probabilistic tractography. Groups showed significant, highly focused differences in DTI parameters which related to @entity1 ' genital responses to sexual depictions of @entity1 , but not to measures of psychopathy or to childhood histories of physical @entity734 , or neglect. Some previously reported gray matter differences were suggested under highly liberal statistical conditions (p uncorrected  <  .005), but did not survive ordinary statistical correction (whole brain per voxel false discovery rate of 5  %). These results confirm that @entity40350 is characterized by neuroanatomical differences in white matter microstructure, over and above any neural characteristics attributable to psychopathy and childhood adversity, which show neuroanatomic footprints of their own. Although some gray matter structures were implicated previously, only few have emerged reliably.

title: Diffusion Tensor Imaging of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'child']

entities_list: @entity40350 :: ('MESH:D010378', 'Disease') :: ['Pedophilia', 'pedophilia']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['abuse, sexual abuse']

answer: @entity40350 :: (MESH:D010378,Disease) :: ['Pedophilia']


abstract: INTRODUCTION: @entity101 is one cause of posterior reversible @entity75 syndrome. @entity101 and @entity385 have only been reported in a few individual case reports. CASE DESCRIPTION: A 51-year-old @entity1 presented with @entity101 @entity75 . T2-weighted images from magnetic resonance imaging showed hyperintense lesions in both occipital and parietal lobes. Diffusion-weighted imaging showed that this represented cytotoxic @entity4 and perfusion magnetic resonance imaging revealed reduced blood volume and flow. The magnetic resonance imaging was repeated 5 months later and subtotal regression of theT2-hyperintensity had occurred. However, small bilateral @entity1188 were seen on T1-weighted images. Perfusion magnetic resonance imaging presented reduced blood volume and flow on the right side. DISCUSSION AND EVALUATION: The @entity1 in this report had posterior reversible @entity75 syndrome caused by @entity101 @entity75 . Magnetic resonance imaging of the brain showed bilateral cytotoxic @entity4 that partially resolved and resulted in small @entity1188 . The imaging findings are compatible with posterior reversible @entity75 syndrome with subtotal resolution and @entity1188 evolution. CONCLUSION: The case report suggests that the presence of @entity101 @entity75 and posterior reversible @entity75 syndrome should alert clinicians and lead to prompt treatment in order to prevent @entity75 .

title: XXXX and @entity385 .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertensive encephalopathy', 'hypertensive']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebral damage', 'encephalopathy']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts', 'infarct']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertensive encephalopathy']


abstract: INTRODUCTION: @entity101 is one cause of posterior reversible @entity75 syndrome. @entity101 and @entity385 have only been reported in a few individual case reports. CASE DESCRIPTION: A 51-year-old @entity1 presented with @entity101 @entity75 . T2-weighted images from magnetic resonance imaging showed hyperintense lesions in both occipital and parietal lobes. Diffusion-weighted imaging showed that this represented cytotoxic @entity4 and perfusion magnetic resonance imaging revealed reduced blood volume and flow. The magnetic resonance imaging was repeated 5 months later and subtotal regression of theT2-hyperintensity had occurred. However, small bilateral @entity1188 were seen on T1-weighted images. Perfusion magnetic resonance imaging presented reduced blood volume and flow on the right side. DISCUSSION AND EVALUATION: The @entity1 in this report had posterior reversible @entity75 syndrome caused by @entity101 @entity75 . Magnetic resonance imaging of the brain showed bilateral cytotoxic @entity4 that partially resolved and resulted in small @entity1188 . The imaging findings are compatible with posterior reversible @entity75 syndrome with subtotal resolution and @entity1188 evolution. CONCLUSION: The case report suggests that the presence of @entity101 @entity75 and posterior reversible @entity75 syndrome should alert clinicians and lead to prompt treatment in order to prevent @entity75 .

title: @entity101 and XXXX .

answer: @entity385 :: (MESH:D002544,Disease) :: ['cerebral infarction']


abstract: UNASSIGNED: Endovascular treatment for superior sagittal sinus (SSS) @entity715 is not always successful because of difficult access and @entity66 . We report the first two cases of @entity1 with @entity50 at the SSS that was not recanalized by anticoagulation, mechanical thrombectomy, or thrombolysis, but was successfully treated by stent placement. Case 1 was a 37-year-old @entity1 with bilateral @entity3439 . Digital subtraction angiography showed obstruction of the sinus from the SSS to the right transverse sinus. Recanalization was achieved by selective thrombolysis using urokinase followed by balloon angioplasty, but re-occlusion occurred on the next day of treatment. Repeated endovascular treatment including balloon angioplasty, @entity715 aspiration and thrombolysis using recombinant tissue plasminogen activator failed to achieve recanalization. We thus placed intracranial stents in the SSS, which did achieve recanalization. Case 2 was a 69-year-old @entity1 with a small @entity1188 in the left parietal lobe. Digital subtraction angiography showed @entity50 from the SSS to the bilateral transverse sinuses. Recanalization was not achieved by balloon angioplasty, @entity715 aspiration and selective thrombolysis. We thus placed intracranial stents in the SSS, which did achieve recanalization. Postoperative course was uneventful in both cases and venous sinus patency was confirmed by venography >1.5 years after treatment. When conventional endovascular strategies have been unsuccessful, placement of intracranial stents, which can easily gain access to the distal part of the SSS as compared with carotid stents, may be a useful treatment option for the acute sinus @entity715 in this region.

title: Stenting for XXXX in the superior sagittal sinus.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity3439 :: ('MESH:D006408', 'Disease') :: ['subdural hematomas']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['long thrombus lesions']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'thrombosis']

entities_list: @entity50 :: ('MESH:D012851', 'Disease') :: ['sinus obliteration', 'acute cerebral venous sinus thrombosis']

answer: @entity50 :: (MESH:D012851,Disease) :: ['acute cerebral venous sinus thrombosis']


abstract: BACKGROUND: The Functioning Assessment Short Test (FAST) was developed for the clinical evaluation of functional impairment of @entity1 suffering from @entity162 . The aim of this study was to validate the Finnish version of FAST. METHODS: Translation and back-translation of FAST were performed. Fifty @entity1 with the Diagnostic and Statistical Manual of Mental Disorders-Fourth edition (DSM-IV) bipolar type I and II were interviewed at the @entity162 Research and Treatment Centre, City of Helsinki, Finland. @entity1 completed the FAST, the Social and Occupational Functioning Assessment Scale (SOFAS) of DSM-IV, and the Sheehan Disability Scale (SDS) as part of the assessment. Internal consistency and correlations between FAST and SOFAS and SDS were analysed. Twenty-five @entity1 participated in a reliability assessment carried out 1 week apart by a different rater. RESULTS AND DISCUSSION: The internal consistency coefficient obtained was very good, with a Cronbach alpha of 0.870. Reliability of FAST was also found excellent (correlation between two measures r   =   0.896, p   <   0.001). A highly significant negative correlation between FAST and SOFAS scores was found (r   =   -0.723, p   <   0.001). FAST and SDS were also highly significantly correlated (r   =   0.742, p   <   0.001). CONCLUSIONS: The psychometric validity and reliability of FAST in the Finnish sample of @entity1 with @entity162 types I and II were good.

title: Validity and reliability of the Finnish version of the Functioning Assessment Short Test (FAST) in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Participants']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['Bipolar Disorder', 'bipolar disorder']

answer: @entity162 :: (MESH:D001714,Disease) :: ['bipolar disorder']


abstract: BACKGROUND: @entity730 ( @entity730 ) or @entity13375 is a severe complication of advanced @entity740 ( @entity740 ) and dialysis. Few effective treatments are available and the mortality rate is high. We report 4 cases in which @entity15451 therapy was rapidly effective. CASES: @entity15451 therapy was given to 4 Caucasian @entity1 (3 females and 1 male aged 49 to 91 years) with @entity730 . The causes of end-stage @entity740 were nephroangiosclerosis (n=2) and @entity2316 (n=2). The lesions developed 1 to 6.5 years after the initiation of hemodialysis and involved the lower limbs in 2 @entity1 , the fingers in 1 @entity1 , and a breast in the remaining @entity1 . They were responsible for @entity158 and @entity39 in all 4 @entity1 . Local superinfection occurred in 3 @entity1 . Intravenous @entity15451 was given in a dosage of 12.5 to 25g after each hemodialysis session, for 12 to 24 weeks. The @entity158 and @entity74 resolved fully in all 4 @entity1 . The side effects consisted of @entity390 and @entity391 (n=2) and a moderate blood pressure decrease (n=1). No recurrences were noted during the follow-up of 5 to 17 months after treatment discontinuation. CONCLUSION: The findings from this small case-series suggest that @entity15451 may hold promise for the treatment of @entity730 .

title: XXXX is effective in @entity730 complicating chronic hemodialysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['skin necrosis']

entities_list: @entity2316 :: ('MESH:D003928', 'Disease') :: ['diabetic nephropathy']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['Calcific uremic arteriolopathy', 'CUA']

entities_list: @entity15451 :: ('MESH:C017717', 'Chemical') :: ['sodium thiosulfate', 'Sodium thiosulfate']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['trophic disorders']

entities_list: @entity13375 :: ('MESH:D002115', 'Disease') :: ['calciphylaxis']

answer: @entity15451 :: (MESH:C017717,Chemical) :: ['Sodium thiosulfate']


abstract: BACKGROUND: @entity730 ( @entity730 ) or @entity13375 is a severe complication of advanced @entity740 ( @entity740 ) and dialysis. Few effective treatments are available and the mortality rate is high. We report 4 cases in which @entity15451 therapy was rapidly effective. CASES: @entity15451 therapy was given to 4 Caucasian @entity1 (3 females and 1 male aged 49 to 91 years) with @entity730 . The causes of end-stage @entity740 were nephroangiosclerosis (n=2) and @entity2316 (n=2). The lesions developed 1 to 6.5 years after the initiation of hemodialysis and involved the lower limbs in 2 @entity1 , the fingers in 1 @entity1 , and a breast in the remaining @entity1 . They were responsible for @entity158 and @entity39 in all 4 @entity1 . Local superinfection occurred in 3 @entity1 . Intravenous @entity15451 was given in a dosage of 12.5 to 25g after each hemodialysis session, for 12 to 24 weeks. The @entity158 and @entity74 resolved fully in all 4 @entity1 . The side effects consisted of @entity390 and @entity391 (n=2) and a moderate blood pressure decrease (n=1). No recurrences were noted during the follow-up of 5 to 17 months after treatment discontinuation. CONCLUSION: The findings from this small case-series suggest that @entity15451 may hold promise for the treatment of @entity730 .

title: @entity15451 is effective in XXXX complicating chronic hemodialysis.

answer: @entity730 :: (MESH:D002114,Disease) :: ['calcific uremic arteriolopathy']


abstract: A report is given of 87 pregnancies in hyperprolactinaemic @entity1 treated with @entity2847 . The high @entity4090 level in 11 cases was caused by hypophyseal @entity652 . If the plasma @entity4090 level exceeded 5000 mU/l during pregnancy, @entity2847 was administered until delivery. If the initial @entity4090 value was over 1000 mU/l, the @entity4090 level was measured during pregnancy, delivery and the lactational period. After weaning, the @entity4090 level was again elevated in the majority of cases. During pregnancy, delivery and lactation, complications which differed significantly from the usual were not observed, pregnancy and nursing took place normally. Breast feeding was not contraindicated in any of the cases. Among the newborns, adaptation disturbances and @entity600 , showed the usual frequency. In the authors' opinion pregnancies which occur during the treatment of hyperprolactinaemic @entity1 need increased care. Complications during pregnancy, delivery and nursing period were not more frequently observed either in the mother or the newborn. The @entity751 did not deteriorate during gestation and lactation, but its normalization can not be expected.

title: Pregnancy, delivery and lactation in hyperprolactinaemic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity2847 :: ('MESH:D001971', 'Chemical') :: ['bromocriptine']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['congenital malformations']

entities_list: @entity751 :: ('MESH:D013577', 'Disease') :: ['hyperprolactinaemic syndrome']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: UNASSIGNED: @entity8 pose a growing epidemiological and health problem worldwide. @entity65 are the leading cause of @entity204 among @entity1 with @entity740 . Increased risk of @entity731 in these @entity1 results from the occurrence of traditional and non-traditional risk factors. The aim of this study was to assess the relationship between selected risk factors for @entity65 (age, sex, @entity2299 , @entity101 , etc.), intima-media thickness and coronary artery @entity460 score in @entity1 with @entity740 stages 2, 3 and 4. This study included 60 @entity1 with @entity740 divided into 3 groups on the basis of disease stage and control group consisting of 20 individuals without diagnosed @entity740 and @entity65 . Blood analysis and blood pressure measurements were taken. All @entity1 underwent carotid artery ultrasound with the assessment of the intima-media thickness, and heart CT scan in order to assess the index of @entity729 . Logistic regression analysis revealed statistically significant correlation between blood vessels @entity730 and age-the increase in age by 1  year was associated with the increase in the risk of @entity729 by 6.7  %. The increase in IMT by about 0.1  mm raises the risk of @entity730 by about 2  %. Second logistic regression model revealed that one-year increase in age was associated with an increase in the risk of intima-media thickening by 6.5  %. Occurrence of @entity101 was associated with a ninefold increase in intima-media thickening risk in comparison with @entity1 with normal blood pressure. To sum up, age and @entity101 were associated with the growth of IMT in CKD @entity1 , while age and exposure to @entity286 smoke were associated with the increase in coronary artery @entity460 score. The relationship between thickening of IMT and the increase in @entity730 index in @entity1 was also observed in study group.

title: Assessment of the relationship between selected cardiovascular risk factors and the indices of intima-media thickness and coronary artery @entity460 score in various stages of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal diseases']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['coronary artery calcification']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases', 'Cardiovascular diseases']

answer: @entity740 :: (MESH:D051436,Disease) :: ['chronic kidney disease']


abstract: UNASSIGNED: @entity8 pose a growing epidemiological and health problem worldwide. @entity65 are the leading cause of @entity204 among @entity1 with @entity740 . Increased risk of @entity731 in these @entity1 results from the occurrence of traditional and non-traditional risk factors. The aim of this study was to assess the relationship between selected risk factors for @entity65 (age, sex, @entity2299 , @entity101 , etc.), intima-media thickness and coronary artery @entity460 score in @entity1 with @entity740 stages 2, 3 and 4. This study included 60 @entity1 with @entity740 divided into 3 groups on the basis of disease stage and control group consisting of 20 individuals without diagnosed @entity740 and @entity65 . Blood analysis and blood pressure measurements were taken. All @entity1 underwent carotid artery ultrasound with the assessment of the intima-media thickness, and heart CT scan in order to assess the index of @entity729 . Logistic regression analysis revealed statistically significant correlation between blood vessels @entity730 and age-the increase in age by 1  year was associated with the increase in the risk of @entity729 by 6.7  %. The increase in IMT by about 0.1  mm raises the risk of @entity730 by about 2  %. Second logistic regression model revealed that one-year increase in age was associated with an increase in the risk of intima-media thickening by 6.5  %. Occurrence of @entity101 was associated with a ninefold increase in intima-media thickening risk in comparison with @entity1 with normal blood pressure. To sum up, age and @entity101 were associated with the growth of IMT in CKD @entity1 , while age and exposure to @entity286 smoke were associated with the increase in coronary artery @entity460 score. The relationship between thickening of IMT and the increase in @entity730 index in @entity1 was also observed in study group.

title: Assessment of the relationship between selected cardiovascular risk factors and the indices of intima-media thickness and coronary artery XXXX score in various stages of @entity740 .

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: In the paper presented here the following parameters on the skin of pure-bred @entity35 inbred @entity35 were investigated during the early postnatal maturation period: DNA-content (according to Burton 1956), @entity1568 -content (according to Strauch 1965), beta-glucuronidase activity (according to Fishman 1974), partly also protein-content (according to Lowry 1951). At the same time, we tested if a single i.p. injection of @entity1667 , applied exactly at the same time of the day 24 h preceding the killing, has an influence on the above mentioned quantities in comparison to the control group (possibly dosage-dependent). In the observation period (2nd, 4th, 6th, 9th, and 14th day) a linear, statistically significant increase of the @entity1568 -content could be stated on the skin. After an initial increase up to the 4th day of life the DNA-content significantly decreases during the following postnatal maturation period until the 14th day. These results could be obtained both in the control groups, and in the animals treated with different dosages of @entity1667 . It is of importance that these parameters (especially the cell and the DNA-content respectively) were not statistically significantly changed by pretreatment with the glucocorticoid at any day investigated. The total activity of the further tested lysosomal indicator-enzyme beta-glucuronidase increases during the postnatal maturation period up to its maximum on the 9th day of life before it decreases till the 14th day. The applied dosages of the glucucorticoid led to a general increase of the enzyme activity, which, however, was only exceptionally statistically significant. This enzyme induction could also by discussed in terms of a maturation acceleration. Dosage-dependent differences could partly be demonstrated.

title: [The influence of a single glucocorticoid administration on the DNA and the XXXX -content as well as on the beta-glucuronidase activity of @entity35 skin during postnatal development (author's transl)].

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['6-methyl-prednisolone']

answer: @entity1568 :: (MESH:D009584,Chemical) :: ['nitrogen']


abstract: In the paper presented here the following parameters on the skin of pure-bred @entity35 inbred @entity35 were investigated during the early postnatal maturation period: DNA-content (according to Burton 1956), @entity1568 -content (according to Strauch 1965), beta-glucuronidase activity (according to Fishman 1974), partly also protein-content (according to Lowry 1951). At the same time, we tested if a single i.p. injection of @entity1667 , applied exactly at the same time of the day 24 h preceding the killing, has an influence on the above mentioned quantities in comparison to the control group (possibly dosage-dependent). In the observation period (2nd, 4th, 6th, 9th, and 14th day) a linear, statistically significant increase of the @entity1568 -content could be stated on the skin. After an initial increase up to the 4th day of life the DNA-content significantly decreases during the following postnatal maturation period until the 14th day. These results could be obtained both in the control groups, and in the animals treated with different dosages of @entity1667 . It is of importance that these parameters (especially the cell and the DNA-content respectively) were not statistically significantly changed by pretreatment with the glucocorticoid at any day investigated. The total activity of the further tested lysosomal indicator-enzyme beta-glucuronidase increases during the postnatal maturation period up to its maximum on the 9th day of life before it decreases till the 14th day. The applied dosages of the glucucorticoid led to a general increase of the enzyme activity, which, however, was only exceptionally statistically significant. This enzyme induction could also by discussed in terms of a maturation acceleration. Dosage-dependent differences could partly be demonstrated.

title: [The influence of a single glucocorticoid administration on the DNA and the @entity1568 -content as well as on the beta-glucuronidase activity of XXXX skin during postnatal development (author's transl)].

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Environmental standards for @entity1300 ( @entity8710 , @entity1300 ) are currently being considered by regulatory agencies worldwide. Among these are limits for tap water, soil at industrial sites, residential soil, fish, ambient air, and @entity238 ash. Thus far, in the United States, no standards have been promulgated but a few have been suggested. This paper critically evaluates several aspects of previously proposed approaches to setting limits for @entity1300 in residential soil and soil within industrial sites. Factors and assumptions which significantly affect the predicted degree of hazard associated with exposure to soil contaminated with low levels of @entity8710 are discussed. This paper shows how different, more justifiable assumptions than those used by the Centers for Disease Control (CDC) regarding the quantities of soil typically consumed by @entity1 , @entity1300 's nongenotoxicity, dermal exposure to soil, the concentration of airborne soil particles, @entity8710 's bioavailability in soil, and extrapolation of the dose response curve can profoundly affect the results of the risk assessment and, subsequently, the magnitude of the recommended limits. Two case studies which quantitatively illustrate the effect of these assumptions on the risk estimates are presented. Non-U.S. regulatory agencies have considered @entity1300 's nongenotoxicity in estimating that the virtually safe dose (VSD) or acceptable daily dose for @entity8710 is approximately 10 pg/kg/day (10,000 fg/kg/day). These approaches are compared and contrasted with the method used by the United States EPA whose risk estimates are higher and whose VSD is approximately 1,000-fold lower. Alternative approaches to interpreting the @entity5 data indicate that a VSD of 130 pg/kg/day is more scientifically justified than risks estimated using standard approaches. This assessment indicates that a soil concentration of @entity1300 considerably in excess of 1 ppb should be acceptable for residential and nonresidential areas.

title: A critical examination of assumptions used in risk assessments of XXXX contaminated soil.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1300 :: ('MESH:D013749', 'Chemical') :: ['TCDD', '2,3,7,8-tetrachlorodibenzo-p-dioxin']

answer: @entity8710 :: (CHEBI:28119,Chemical) :: ['dioxin']


abstract: In @entity195 ( @entity195 ), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with @entity528 , is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of @entity195 subjects suggests a sequence of initiation and subsequent spread of neurofibrillary tau tangles along defined brain anatomical pathways. Further, the severity of @entity73 correlates with the degree and extent of tau pathology. In this study, we demonstrate that phospho-tau (p-tau) antibodies, @entity72034 and @entity41049 , can prevent the induction of tau pathology in primary neuron cultures. The impact of passive immunotherapy on the formation and spread of tau pathology, as well as functional deficits, was subsequently evaluated with these antibodies in two distinct transgenic @entity19 @entity13859 models. The rTg4510 transgenic @entity19 is characterized by inducible over-expression of @entity18824 mutant tau, and exhibits robust age-dependent brain tau pathology. Systemic treatment with @entity72034 and @entity41049 from 3 to 6 months of age led to a significant decline in brain and CSF p-tau levels. In a second model, injection of preformed tau fibrils (PFFs) comprised of recombinant tau protein encompassing the microtubule-repeat domains into the cortex and hippocampus of young @entity18825 mutant tau over-expressing @entity19 (PS19) led to robust tau pathology on the ipsilateral side with evidence of spread to distant sites, including the contralateral hippocampus and bilateral entorhinal cortex 4 weeks post-injection. Systemic treatment with @entity41049 led to a significant decline in the spread of tau pathology in this model. The reduction in tau species after p-tau antibody treatment was associated with an improvement in novel-object recognition memory test in both models. These studies provide evidence supporting the use of tau immunotherapy as a potential treatment option for @entity195 and other @entity13859 .

title: Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct @entity19 XXXX models.

entities_list: @entity13859 :: ('MESH:D024801', 'Disease') :: ['tauopathies', 'tauopathy']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive deficits']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal loss']

answer: @entity13859 :: (MESH:D024801,Disease) :: ['tauopathy']


abstract: In @entity195 ( @entity195 ), an extensive accumulation of extracellular amyloid plaques and intraneuronal tau tangles, along with @entity528 , is evident in distinct brain regions. Staging of tau pathology by postmortem analysis of @entity195 subjects suggests a sequence of initiation and subsequent spread of neurofibrillary tau tangles along defined brain anatomical pathways. Further, the severity of @entity73 correlates with the degree and extent of tau pathology. In this study, we demonstrate that phospho-tau (p-tau) antibodies, @entity72034 and @entity41049 , can prevent the induction of tau pathology in primary neuron cultures. The impact of passive immunotherapy on the formation and spread of tau pathology, as well as functional deficits, was subsequently evaluated with these antibodies in two distinct transgenic @entity19 @entity13859 models. The rTg4510 transgenic @entity19 is characterized by inducible over-expression of @entity18824 mutant tau, and exhibits robust age-dependent brain tau pathology. Systemic treatment with @entity72034 and @entity41049 from 3 to 6 months of age led to a significant decline in brain and CSF p-tau levels. In a second model, injection of preformed tau fibrils (PFFs) comprised of recombinant tau protein encompassing the microtubule-repeat domains into the cortex and hippocampus of young @entity18825 mutant tau over-expressing @entity19 (PS19) led to robust tau pathology on the ipsilateral side with evidence of spread to distant sites, including the contralateral hippocampus and bilateral entorhinal cortex 4 weeks post-injection. Systemic treatment with @entity41049 led to a significant decline in the spread of tau pathology in this model. The reduction in tau species after p-tau antibody treatment was associated with an improvement in novel-object recognition memory test in both models. These studies provide evidence supporting the use of tau immunotherapy as a potential treatment option for @entity195 and other @entity13859 .

title: Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct XXXX @entity13859 models.

answer: @entity19 :: (10090,Species) :: ['mouse']