abstract: In @entity3052 ( @entity3052 -46 @entity1 ) and various entities of chronic @entity66 ( @entity32942 -58 @entity1 ) an evaluation and comparison of clinical and postmortem findings has been performed. This study included also aspirates and core biopsies of the bone marrow which were initially taken on admission of those @entity1 . Classification of @entity32942 was done following the concept of Georgii et al. (1984) into CGL -24-, CMGM-6-, E- @entity15 -13- and @entity15 /OMS-15 cases. There was a significant increase in blastic crisis in CGL compared with the other entities and in the latter a prolongation of the total course of disease due to a long period between symptoms--clinical diagnosis. As revealed by the autopsies causes of @entity204 were @entity281 ( @entity55 , @entity295 -50%) and lethal @entity548 (gastrointestinal and cerebral--about 30%) in both @entity3052 and CMGM @entity1 . Rare causes comprised fatal @entity1151 due to a peripheral @entity1148 in @entity32942 , @entity2617 of the myocard in @entity3052 . In addition to the well known giant enlargement of the spleen in @entity15 /OMS, the relatively high frequency of a @entity693 (meningeosis leukemica) in @entity3052 (about 35%) and during an acute transformation in @entity32942 (up to 30%) was conspicuous. The examination of the bone marrow at various sites became feasible during the postmortem procedure and thus provided the opportunity to investigate the development and extent of a @entity4018 evolving in @entity32942 . In contrast to the a- or @entity509 and regeneration of the @entity1210 following chemotherapy, the evolution of @entity75 showed a very uniform pattern throughout the skeleton and obviously no reversal of a manifest @entity15 /OMS after cytotoxic treatment.

title: Autopsy and clinical findings in XXXX and chronic @entity66 --an evaluation of 104 @entity1 .

answer: @entity3052 :: (MESH:D015470,Disease) :: ['acute leukemia']


abstract: In @entity3052 ( @entity3052 -46 @entity1 ) and various entities of chronic @entity66 ( @entity32942 -58 @entity1 ) an evaluation and comparison of clinical and postmortem findings has been performed. This study included also aspirates and core biopsies of the bone marrow which were initially taken on admission of those @entity1 . Classification of @entity32942 was done following the concept of Georgii et al. (1984) into CGL -24-, CMGM-6-, E- @entity15 -13- and @entity15 /OMS-15 cases. There was a significant increase in blastic crisis in CGL compared with the other entities and in the latter a prolongation of the total course of disease due to a long period between symptoms--clinical diagnosis. As revealed by the autopsies causes of @entity204 were @entity281 ( @entity55 , @entity295 -50%) and lethal @entity548 (gastrointestinal and cerebral--about 30%) in both @entity3052 and CMGM @entity1 . Rare causes comprised fatal @entity1151 due to a peripheral @entity1148 in @entity32942 , @entity2617 of the myocard in @entity3052 . In addition to the well known giant enlargement of the spleen in @entity15 /OMS, the relatively high frequency of a @entity693 (meningeosis leukemica) in @entity3052 (about 35%) and during an acute transformation in @entity32942 (up to 30%) was conspicuous. The examination of the bone marrow at various sites became feasible during the postmortem procedure and thus provided the opportunity to investigate the development and extent of a @entity4018 evolving in @entity32942 . In contrast to the a- or @entity509 and regeneration of the @entity1210 following chemotherapy, the evolution of @entity75 showed a very uniform pattern throughout the skeleton and obviously no reversal of a manifest @entity15 /OMS after cytotoxic treatment.

title: Autopsy and clinical findings in @entity3052 and chronic @entity66 --an evaluation of 104 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['septicemia']

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocytosis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['myeloproliferative diseases']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhages']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity2617 :: ('MESH:D017254', 'Disease') :: ['acute rupture of the spleen and extensive leukemic infiltrates']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['myelosclerotic lesions']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['pulmonary embolism']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['mostly infections']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningeal involvement']

entities_list: @entity4018 :: ('MESH:D055728', 'Disease') :: ['myelosclerosis']

entities_list: @entity509 :: ('MESH:C538429', 'Disease') :: ['hypoplasia']

entities_list: @entity1210 :: ('MESH:C536227', 'Disease') :: ['hematopoiesis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVES: To describe the prevalence of hysterectomy for @entity1 aged 18-45 seeking treatment at a @entity1118 clinic, to describe @entity1 characteristics ( @entity158 intensity, age, smoking status, hormone replacement status, and psychosocial factors) based on opioid and hysterectomy status, and to determine whether hysterectomy status predicted receipt of opioid prescription. DESIGN: Retrospective cross-sectional chart review. @entity1 : Total 323 new female @entity1 aged 18-45 who completed the Brief @entity158 Inventory-Short Form at initial evaluation at a @entity1118 clinic during a 12-month period (July 2008-June 2009). MEASURES: Data were collected from the Brief @entity158 Inventory and medical charts. Variables included opioid prescription, average @entity158 intensity, @entity158 type, age, hysterectomy status, smoking status, and @entity158 across domains measured by the Brief @entity158 Inventory. The association of opioid prescription with hysterectomy and other factors were determined by logistic regression. RESULTS: Prevalence of hysterectomy was 28.8%. Average @entity158 intensity was not associated with either hysterectomy or opioid prescription status. However, hysterectomy and high levels of @entity158 were significantly and independently associated with opioid prescription after adjusting for age and @entity158 intensity. More than 85% of @entity1 with hysterectomy and high @entity158 had opioid prescription. CONCLUSIONS: Hysterectomy may confer risk for @entity158 and opioid prescription in @entity1 45 and younger. More research is needed to understand 1) how @entity1 characteristics influence prescribing patterns and 2) the specific medical risks and consequences of chronic opioid therapy in this population.

title: Hysterectomy and predictors for opioid prescription in a XXXX clinic sample.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'PARTICIPANTS']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['Pain', 'pain', 'pain-related dysfunction']

answer: @entity1118 :: (MESH:D059350,Disease) :: ['chronic pain']


abstract: BACKGROUND: The promotion of physical activity among an overweight/ @entity28 population is an important challenge for clinical practitioners and researchers. In this regard, completing a questionnaire on cognitions could be a simple and easy strategy to increase levels of physical activity. Thus, the aim of the present study was to test the effect of completing a questionnaire based on the Theory of Planned Behavior (TPB) on the level of physical activity. METHODS: Overall, 452 overweight/ @entity28 adults were recruited and randomized to the experimental or control group. At baseline, @entity1 completed a questionnaire on cognitions regarding their participation in leisure-time physical activity (experimental condition) versus a questionnaire on fruit and vegetable consumption (control condition). The questionnaires assessed the TPB variables that are beliefs, attitude, norm, perception of control, intention and a few additional variables from other theories. At three-month follow-up, leisure-time physical activity was self-reported by means of a short questionnaire. An analysis of covariance with baseline physical activity level as covariate was used to verify the effect of the intervention. RESULTS: At follow-up, 373 @entity1 completed the leisure-time physical activity questionnaire. The statistical analysis showed that physical activity participation was greater among @entity1 in the experimental condition than those in the control condition (F(1,370)=6.85, p=.009, d=0.20). CONCLUSIONS: Findings indicate that completing a TPB questionnaire has a significant positive impact on subsequent participation in physical activity. Consequently, asking individuals to complete such a questionnaire is a simple, inexpensive and easy strategy to increase the level of physical activity among overweight/ @entity28 adults.

title: The effect of mere-measurement of cognitions on physical activity behavior: a randomized controlled trial among overweight and XXXX individuals.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: OBJECTIVE: Performance of middle-ear surgery under local anaesthesia has several advantages, but many @entity1 complain of @entity158 , @entity148 and adverse events (e.g. dizziness and @entity390 ). To minimise such problems, we compared sedation with @entity1363 alone versus @entity1363 with @entity1937 . @entity1 AND METHODS: We initially observed 19 @entity1 undergoing middle-ear surgery under local anaesthesia, as controls. We then sedated a further 40 @entity1 undergoing such surgery, with either @entity1363 or @entity1363 plus @entity1937 . RESULTS: The sedated @entity1 had significantly lower incidences of local anaesthesia injection @entity158 (p < 0.001), intra-operative @entity158 (p < 0.001), intra-operative @entity148 (p < 0.001) and adverse events, compared with the control group. @entity1 sedated with @entity1363 plus @entity1937 reported less intra-operative @entity148 (p = 0.010) and greater post-operative satisfaction with sedation (p = 0.007), compared with those sedated with @entity1363 only. CONCLUSION: @entity1 undergoing middle-ear surgery under local anaesthesia alone frequently report @entity158 , @entity148 and adverse events. However, the majority of our @entity1 who were sedated with @entity1363 satisfactorily overcame @entity158 , @entity148 and adverse events. Results were better still when @entity1363 was accompanied by @entity1937 .

title: Middle-ear surgery under sedation: comparison of @entity1363 alone or @entity1363 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam']

entities_list: @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil']

answer: @entity1937 :: (MESH:C071741,Chemical) :: ['remifentanil']


abstract: OBJECTIVE: Performance of middle-ear surgery under local anaesthesia has several advantages, but many @entity1 complain of @entity158 , @entity148 and adverse events (e.g. dizziness and @entity390 ). To minimise such problems, we compared sedation with @entity1363 alone versus @entity1363 with @entity1937 . @entity1 AND METHODS: We initially observed 19 @entity1 undergoing middle-ear surgery under local anaesthesia, as controls. We then sedated a further 40 @entity1 undergoing such surgery, with either @entity1363 or @entity1363 plus @entity1937 . RESULTS: The sedated @entity1 had significantly lower incidences of local anaesthesia injection @entity158 (p < 0.001), intra-operative @entity158 (p < 0.001), intra-operative @entity148 (p < 0.001) and adverse events, compared with the control group. @entity1 sedated with @entity1363 plus @entity1937 reported less intra-operative @entity148 (p = 0.010) and greater post-operative satisfaction with sedation (p = 0.007), compared with those sedated with @entity1363 only. CONCLUSION: @entity1 undergoing middle-ear surgery under local anaesthesia alone frequently report @entity158 , @entity148 and adverse events. However, the majority of our @entity1 who were sedated with @entity1363 satisfactorily overcame @entity158 , @entity148 and adverse events. Results were better still when @entity1363 was accompanied by @entity1937 .

title: Middle-ear surgery under sedation: comparison of XXXX alone or @entity1363 with @entity1937 .

answer: @entity1363 :: (MESH:D008874,Chemical) :: ['midazolam']


abstract: OBJECTIVE: Performance of middle-ear surgery under local anaesthesia has several advantages, but many @entity1 complain of @entity158 , @entity148 and adverse events (e.g. dizziness and @entity390 ). To minimise such problems, we compared sedation with @entity1363 alone versus @entity1363 with @entity1937 . @entity1 AND METHODS: We initially observed 19 @entity1 undergoing middle-ear surgery under local anaesthesia, as controls. We then sedated a further 40 @entity1 undergoing such surgery, with either @entity1363 or @entity1363 plus @entity1937 . RESULTS: The sedated @entity1 had significantly lower incidences of local anaesthesia injection @entity158 (p < 0.001), intra-operative @entity158 (p < 0.001), intra-operative @entity148 (p < 0.001) and adverse events, compared with the control group. @entity1 sedated with @entity1363 plus @entity1937 reported less intra-operative @entity148 (p = 0.010) and greater post-operative satisfaction with sedation (p = 0.007), compared with those sedated with @entity1363 only. CONCLUSION: @entity1 undergoing middle-ear surgery under local anaesthesia alone frequently report @entity158 , @entity148 and adverse events. However, the majority of our @entity1 who were sedated with @entity1363 satisfactorily overcame @entity158 , @entity148 and adverse events. Results were better still when @entity1363 was accompanied by @entity1937 .

title: Middle-ear surgery under sedation: comparison of @entity1363 alone or XXXX with @entity1937 .

answer: @entity1363 :: (MESH:D008874,Chemical) :: ['midazolam']


abstract: OBJECTIVE: To explore the value of @entity855 - @entity5 chemosensitivity assay ( @entity855 - @entity2974 ) in individualized treatment of recurrent @entity43 (REOC), and to evaluate the correlation between the in vitro chemosensitivity assay and clinical drug sensitivity. METHODS: Sixty-nine REOC specimens were tested by @entity855 - @entity2974 assay retrospectively. The @entity1 were divided into strong sensitive, moderate sensitively and resistant groups according to the @entity855 - @entity2974 assay results. The clinical results were evaluated according to imaging and serum @entity10224 analysis. The correlation between in vitro @entity855 - @entity2974 assay and clinical outcome was statistically analyzed by   (2) test. The progression free survival (PFS) and overall survival (OS) of each group were analyzed using Kaplan-Meier method. RESULTS: The results of @entity855 - @entity2974 assay had significant correlation with clinical outcome. The clinical chemotherapy outcome became better with increased drug sensitivity in vitro (  (2) = 9.066, P = 0.004). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate for @entity855 - @entity2974 method to predict the clinical chemotherapy sensitivity of REOC were 87.5%, 45.9%, 58.3%, 80.9% and 65.2%, respectively. The mean PFS of strong sensitive group, moderately sensitive group and resistant group were 187.1 days, 195.0 days and 60.3 days, respectively. The mean OS were 476.7, 335.7 and 237.5 days, respectively, following the start of @entity2974 -directed therapy. The PFS and OS of the two sensitivity groups in vitro were significantly longer than that of the in vitro-resistant group (P < 0.01). CONCLUSION: The results of @entity855 - @entity2974 assay are well correlated with clinical treatment responses. The assay may be an important and useful method for individualized chemotherapy for recurrent @entity43 .

title: [Application of XXXX - @entity5 chemosensitivity assay in recurrent @entity43 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer', 'epithelial ovarian cancer']

entities_list: @entity855 :: ('MESH:D000255', 'Chemical') :: ['adenosine triphosphate', 'ATP']

answer: @entity855 :: (MESH:D000255,Chemical) :: ['ATP']


abstract: OBJECTIVE: To explore the value of @entity855 - @entity5 chemosensitivity assay ( @entity855 - @entity2974 ) in individualized treatment of recurrent @entity43 (REOC), and to evaluate the correlation between the in vitro chemosensitivity assay and clinical drug sensitivity. METHODS: Sixty-nine REOC specimens were tested by @entity855 - @entity2974 assay retrospectively. The @entity1 were divided into strong sensitive, moderate sensitively and resistant groups according to the @entity855 - @entity2974 assay results. The clinical results were evaluated according to imaging and serum @entity10224 analysis. The correlation between in vitro @entity855 - @entity2974 assay and clinical outcome was statistically analyzed by   (2) test. The progression free survival (PFS) and overall survival (OS) of each group were analyzed using Kaplan-Meier method. RESULTS: The results of @entity855 - @entity2974 assay had significant correlation with clinical outcome. The clinical chemotherapy outcome became better with increased drug sensitivity in vitro (  (2) = 9.066, P = 0.004). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate for @entity855 - @entity2974 method to predict the clinical chemotherapy sensitivity of REOC were 87.5%, 45.9%, 58.3%, 80.9% and 65.2%, respectively. The mean PFS of strong sensitive group, moderately sensitive group and resistant group were 187.1 days, 195.0 days and 60.3 days, respectively. The mean OS were 476.7, 335.7 and 237.5 days, respectively, following the start of @entity2974 -directed therapy. The PFS and OS of the two sensitivity groups in vitro were significantly longer than that of the in vitro-resistant group (P < 0.01). CONCLUSION: The results of @entity855 - @entity2974 assay are well correlated with clinical treatment responses. The assay may be an important and useful method for individualized chemotherapy for recurrent @entity43 .

title: [Application of @entity855 - XXXX chemosensitivity assay in recurrent @entity43 ].

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: OBJECTIVE: To explore the value of @entity855 - @entity5 chemosensitivity assay ( @entity855 - @entity2974 ) in individualized treatment of recurrent @entity43 (REOC), and to evaluate the correlation between the in vitro chemosensitivity assay and clinical drug sensitivity. METHODS: Sixty-nine REOC specimens were tested by @entity855 - @entity2974 assay retrospectively. The @entity1 were divided into strong sensitive, moderate sensitively and resistant groups according to the @entity855 - @entity2974 assay results. The clinical results were evaluated according to imaging and serum @entity10224 analysis. The correlation between in vitro @entity855 - @entity2974 assay and clinical outcome was statistically analyzed by   (2) test. The progression free survival (PFS) and overall survival (OS) of each group were analyzed using Kaplan-Meier method. RESULTS: The results of @entity855 - @entity2974 assay had significant correlation with clinical outcome. The clinical chemotherapy outcome became better with increased drug sensitivity in vitro (  (2) = 9.066, P = 0.004). The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rate for @entity855 - @entity2974 method to predict the clinical chemotherapy sensitivity of REOC were 87.5%, 45.9%, 58.3%, 80.9% and 65.2%, respectively. The mean PFS of strong sensitive group, moderately sensitive group and resistant group were 187.1 days, 195.0 days and 60.3 days, respectively. The mean OS were 476.7, 335.7 and 237.5 days, respectively, following the start of @entity2974 -directed therapy. The PFS and OS of the two sensitivity groups in vitro were significantly longer than that of the in vitro-resistant group (P < 0.01). CONCLUSION: The results of @entity855 - @entity2974 assay are well correlated with clinical treatment responses. The assay may be an important and useful method for individualized chemotherapy for recurrent @entity43 .

title: [Application of @entity855 - @entity5 chemosensitivity assay in recurrent XXXX ].

answer: @entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian cancer']


abstract: Sleep behavior between 1/2 and 5 years in 320 Swiss @entity1 of the first Zurich longitudinal study is reported. The average length of night sleep between 1/2 and 5 years was 11 to 12 hours. Day sleep was noted in 96% of the @entity1 between 6 and 24 months, and in 20% at age 5. The total length of sleep between 6 and 18 months was 15 hours per 24 hours. It diminished to 12 hours at age 5. There was a large individual variability of day sleep and of night sleep at all ages. Positive correlations were found between the lengths of day sleep at different ages and between the lengths of night sleep at different ages. The length of day sleep and that of night sleep was negatively correlated between 2 and 5 years. Evening wakefulness was observed in 16% and night waking in 40 to 50% of all @entity1 . 18% woke up at least once each night. Night wakening between 2 and 5 years was positively correlated. In about half of the @entity1 with evening wakefulness and/or night wakening these @entity146 were considered as abnormal by the mothers.

title: [The development of XXXX within the first 5 years of life].

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['sleep behaviors']

answer: @entity146 :: (MESH:D001523,Disease) :: ['sleep behavior']


abstract: Superior insights into molecular mechanisms of @entity1578 , which are not fully understood, will help strategies for inducing @entity409 . We examined hepatotoxic mechanisms in @entity19 homozygous for the severe combined @entity3230 mutation in the protein kinase, DNA-activated, catalytic polypeptide. @entity19 were treated with @entity1215 , @entity3174 , and @entity6560 . The ensuing @entity879 was characterized by serological, histological, and mRNA studies. Subsequently, we studied whether transplantation of hepatocytes could rescue animals with @entity1578 . We found extensive @entity409 in these animals, with mortality over several days. The expression of multiple hepatic genes was rapidly altered, including those representing pathways in oxidative/metabolic stress, @entity32 , DNA damage-repair, and @entity1129 mutant ( @entity2155 ) signaling pathways. This led to liver cell growth arrest involving cyclin-dependent kinase inhibitor 1A. Transplantation of hepatocytes with microcarriers in the peritoneal cavity efficiently rescued animals with @entity1578 . @entity74 rapidly reversed, including in hepatic @entity2155 and downstream signaling pathways; and residual hepatocytes overcame cyclin-dependent kinase inhibitor 1A-induced cell growth arrest. Reseeding of the liver with transplanted hepatocytes was not required for rescue because native hepatocytes overcame cell growth-arrest to regenerate the liver. This likely resulted from paracrine signaling from hepatocytes in the peritoneal cavity. We concluded that @entity2155 signaling played critical roles in the pathological features of @entity1578 . These studies should help redirect examination of pathophysiologic and therapeutic mechanisms in @entity1578 .

title: Perturbations in XXXX mutant signaling pathways after drug-induced @entity879 and their reversal during rescue of animals by cell therapy.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity6560 :: ('MESH:D016686', 'Chemical') :: ['monocrotaline']

entities_list: @entity879 :: ('MESH:D017114', 'Disease') :: ['acute liver failure']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver regeneration', 'liver damage']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['liver failure']

entities_list: @entity3174 :: ('MESH:D010672', 'Chemical') :: ['phenytoin']

entities_list: @entity1215 :: ('MESH:D012293', 'Chemical') :: ['rifampicin']

entities_list: @entity1129 :: ('MESH:D001260', 'Disease') :: ['ataxia telangiectasia']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['Molecular abnormalities']

entities_list: @entity3230 :: ('MESH:C565469', 'Disease') :: ['immune deficiency']

answer: @entity1129 :: (MESH:D001260,Disease) :: ['ataxia telangiectasia']


abstract: Superior insights into molecular mechanisms of @entity1578 , which are not fully understood, will help strategies for inducing @entity409 . We examined hepatotoxic mechanisms in @entity19 homozygous for the severe combined @entity3230 mutation in the protein kinase, DNA-activated, catalytic polypeptide. @entity19 were treated with @entity1215 , @entity3174 , and @entity6560 . The ensuing @entity879 was characterized by serological, histological, and mRNA studies. Subsequently, we studied whether transplantation of hepatocytes could rescue animals with @entity1578 . We found extensive @entity409 in these animals, with mortality over several days. The expression of multiple hepatic genes was rapidly altered, including those representing pathways in oxidative/metabolic stress, @entity32 , DNA damage-repair, and @entity1129 mutant ( @entity2155 ) signaling pathways. This led to liver cell growth arrest involving cyclin-dependent kinase inhibitor 1A. Transplantation of hepatocytes with microcarriers in the peritoneal cavity efficiently rescued animals with @entity1578 . @entity74 rapidly reversed, including in hepatic @entity2155 and downstream signaling pathways; and residual hepatocytes overcame cyclin-dependent kinase inhibitor 1A-induced cell growth arrest. Reseeding of the liver with transplanted hepatocytes was not required for rescue because native hepatocytes overcame cell growth-arrest to regenerate the liver. This likely resulted from paracrine signaling from hepatocytes in the peritoneal cavity. We concluded that @entity2155 signaling played critical roles in the pathological features of @entity1578 . These studies should help redirect examination of pathophysiologic and therapeutic mechanisms in @entity1578 .

title: Perturbations in @entity1129 mutant signaling pathways after drug-induced XXXX and their reversal during rescue of animals by cell therapy.

answer: @entity879 :: (MESH:D017114,Disease) :: ['acute liver failure']


abstract: Forty-five @entity1 with @entity3153 ( @entity3153 ) were reviewed. The preexcitation using Boineau's classification was: right anterior (six @entity1 ), left lateral (nine @entity1 ), right posterior (15 @entity1 ) and left posterior (15 @entity1 ). Normal pathway conduction was observed to occur either spontaneously or after administration of @entity8655 , @entity1818 , or by eye-ball pressure. Disappearance of preexcitation was associated with T wave abnormalities in 39 @entity1 (86.6%). The orientation of the T @entity2414 ( @entity2414 ), after suppression of the @entity3153 aspect, varied according to the site of ventricular preexcitation. In eight @entity1 with left lateral ventricular preexcitation (LLVP), the frontal T wave @entity2270 was between +70 degrees and +120 degrees (mean +92 degrees) and the horizontal T wave @entity2270 was located in the left anterior quadrant. In the five @entity1 with right anterior ventricular preexcitation (RAVP), the frontal @entity2270 was between + 40 degrees and - 10 degrees (mean + 26 degrees) and the horizontal @entity2270 was in the left posterior quadrant. The 26 cases with right posterior ventricular preexcitation (RPVP) and left posterior ventricular preexcitation (LPVP) had a frontal @entity2270 between - 10 degrees and - 70 degrees (mean -39 degrees) and the horizontal T wave @entity2270 in the left anterior quadrant. This study suggests that the T wave anomalies observed after suppression of the @entity3153 aspect are in direct relation to the localization of the preexcitation according to Boineau's classification. The analogy between the abnormalities of the T wave and those which are observed after right @entity67 ( @entity67 ) or after disappearance of @entity714 ( @entity714 ) is discussed.

title: XXXX : T wave abnormalities during normal pathway conduction.

entities_list: @entity8655 :: ('MESH:D000404', 'Chemical') :: ['ajmaline']

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['spatial vector', 'SAT']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular pacing', 'VP']

entities_list: @entity714 :: ('MESH:D002037', 'Disease') :: ['left bundle branch block', 'LBBB']

entities_list: @entity3153 :: ('MESH:D014927', 'Disease') :: ['Wolff-Parkinson-White syndrome', 'WPW']

entities_list: @entity1818 :: ('MESH:D011342', 'Chemical') :: ['procainamide']

answer: @entity3153 :: (MESH:D014927,Disease) :: ['Wolff-Parkinson-White syndrome']


abstract: Corrective surgery for @entity1736 under local anaesthesia as day cases was carried out on 162 @entity1 . All had 10 to 14 mm resection of the levator complex with an attached 2 mm strip of tarsal plate, always via a conjunctival approach. If indicated, simultaneous blepharoplasty was also performed. To simplify the surgical and parasurgical management, the author has progressively introduced modifications in the techniques of local anaesthesia, and in the surgical technique. These enable clear and clean isolation of the various tissue planes. The local anaesthesia including facial @entity616 is given at least 30 minutes pre-operatively to prevent @entity9663 . Orbital compression is applied to achieve orbital decongestion, and an @entity551 avascular surgical field. This coupled with the use of microsurgical instruments for surgery under 3 times spectacle magnification allows proper delineation of surgical planes. The average surgical time is 20 minutes. @entity1 are allowed home within 2 hours of surgery, are seen for first dressing at 48 hours, and then for suture removal on the 7th post-operative day. There have been no corneal or other complications in any @entity1 . Suboptimal cosmetic results in 2 @entity1 were corrected by further surgery under local anaesthesia as day cases.

title: Day surgery management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity9663 :: ('MESH:D001764', 'Disease') :: ['blepharospasm']

entities_list: @entity1736 :: ('MESH:D001763', 'Disease') :: ['senile ptosis']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['nerve block']

answer: @entity1736 :: (MESH:D001763,Disease) :: ['senile ptosis']


abstract: A 54-yr-old @entity1 was admitted to Hokkaido University Hospital, complaining of @entity221 , multiple @entity4841 , @entity4 erythema and face and @entity425 of extremities during the last 2 months. He was diagnosed as @entity6017 by acceleration of ESR, elevation of GOT, @entity6283 , @entity9153 , aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the @entity1819 , a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the @entity5 , retrospectively. About 4 months later, abnormal @entity158 occurred and a mass was palpable in the left lumbar region, suggesting a @entity788 . He was operated on excising the @entity5 , but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. @entity204 occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a @entity5 as large as an @entity1 's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric @entity5 revealed a typical @entity957 with keratinization. According to the absence of the components of @entity420 and squamous metaplastic gastric mucosa of non-cancerous areas in the @entity1819 , it seemed likely to be a @entity957 . It was unknown about the precedence between the @entity5 and @entity6017 . There have been 11 cases of primary @entity957 in the world literature since 1968, but this is the first case report of coexistence of these two diseases.

title: [A case report of a primary XXXX of the @entity1819 associated with @entity6017 (author's transl)].

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic tumor']

entities_list: @entity6017 :: ('MESH:D003882', 'Disease') :: ['dermatomyositis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'stomach tumor', 'stomach cancer']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['edematous']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma', 'heterotopic squamous cell carcinoma', 'pure squamous cell carcinoma']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['muscular weakness']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

entities_list: @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia']

answer: @entity957 :: (MESH:D002294,Disease) :: ['pure squamous cell carcinoma']


abstract: A 54-yr-old @entity1 was admitted to Hokkaido University Hospital, complaining of @entity221 , multiple @entity4841 , @entity4 erythema and face and @entity425 of extremities during the last 2 months. He was diagnosed as @entity6017 by acceleration of ESR, elevation of GOT, @entity6283 , @entity9153 , aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the @entity1819 , a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the @entity5 , retrospectively. About 4 months later, abnormal @entity158 occurred and a mass was palpable in the left lumbar region, suggesting a @entity788 . He was operated on excising the @entity5 , but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. @entity204 occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a @entity5 as large as an @entity1 's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric @entity5 revealed a typical @entity957 with keratinization. According to the absence of the components of @entity420 and squamous metaplastic gastric mucosa of non-cancerous areas in the @entity1819 , it seemed likely to be a @entity957 . It was unknown about the precedence between the @entity5 and @entity6017 . There have been 11 cases of primary @entity957 in the world literature since 1968, but this is the first case report of coexistence of these two diseases.

title: [A case report of a primary @entity957 of the @entity1819 associated with XXXX (author's transl)].

answer: @entity6017 :: (MESH:D003882,Disease) :: ['dermatomyositis']


abstract: A 54-yr-old @entity1 was admitted to Hokkaido University Hospital, complaining of @entity221 , multiple @entity4841 , @entity4 erythema and face and @entity425 of extremities during the last 2 months. He was diagnosed as @entity6017 by acceleration of ESR, elevation of GOT, @entity6283 , @entity9153 , aldolase, moderate increases of collagen fibers in biopsy specimen of skin and his clinical signs. Although stools were positive for occult blood, the routine radiographic examination failed to detect the bleeding site in the upper GI. tract. However, in the double contrast picture of the @entity1819 , a very fine abnormal linear shadow was observed at the upper corpus of the lesser curvature. This linear shadow was a margin of the @entity5 , retrospectively. About 4 months later, abnormal @entity158 occurred and a mass was palpable in the left lumbar region, suggesting a @entity788 . He was operated on excising the @entity5 , but was performed only exploratory laparotomy because of the presence of intra-abdominal metastases. @entity204 occurred 40 days after the operation and necropsy was done. The gross anatomical findings of the abdomen showed a @entity5 as large as an @entity1 's head and its metastases to pancreas, lymph nodes, and greater and lesser omentum. Esophageal mucosa including esophagocardiac junction was intact. Histological examination of the intragastric @entity5 revealed a typical @entity957 with keratinization. According to the absence of the components of @entity420 and squamous metaplastic gastric mucosa of non-cancerous areas in the @entity1819 , it seemed likely to be a @entity957 . It was unknown about the precedence between the @entity5 and @entity6017 . There have been 11 cases of primary @entity957 in the world literature since 1968, but this is the first case report of coexistence of these two diseases.

title: [A case report of a primary @entity957 of the XXXX associated with @entity6017 (author's transl)].

answer: @entity1819 :: (MESH:D013272,Disease) :: ['stomach']


abstract: The influence of interactions between dietary fat and protein on spontaneous diseases was investigated in @entity329 fed two levels of @entity4336 oil [4.5 or 18 g/385 kilocalories (kcal)] with each of two levels of casein (9 or 36 g/385 kcal). The four diets were fed to separate groups in two different sequences: 1) Diets were given during weeks 3-7 and followed by control diet (9 g @entity4336 oil and 18 g casein/385 kcal), or 2) control diet was fed during weeks 3-7, and the four diets were fed from week 8 until @entity204 . Dietary interactions of fat and protein modified spontaneous degenerative, inflammatory, and @entity66 in hamsters. For example, @entity409 , spleen, and adrenal glands was reduced in females by feeding @entity2101 ( @entity2101 ) diet in comparison with low-fat-high-protein (LF-HP) diet during weeks 3-7 or by feeding LP diets at either fat level after 8 weeks. The incidence of @entity99 was highest in males consuming HP diet at either fat level after 8 weeks, and @entity99 was observed most often in hamsters fed @entity2101 diet after 8 weeks. Gastric and renal @entity729 and @entity11604 incidences were reduced by 50-100% in hamsters fed @entity2101 diet after 8 weeks, and HF diet fed at this time reduced @entity729 in the heart in both sexes and in the lungs in males. @entity32 was generally influenced similarly by diets fed either during weeks 3-7 or after 8 weeks. In the prostate gland, @entity32 was observed most frequently in males fed HF-LP diet; however, in the vagina @entity32 was elevated in females fed @entity2101 diet and found in the gallbladder more commonly in hamsters fed @entity2101 than in those given LF-HP. The incidence of @entity1960 was decreased by giving HF-LP diet during weeks 3-7 or LF-LP diets after week 8. The incidence of gastric @entity1066 was high in males fed HF diets during weeks 3-7, and intestinal @entity1066 were high in those fed LF-LP at this time. The @entity774 incidence was highest in males given @entity2101 diet before or after 8 weeks and in females given this diet after 8 weeks. Similarly, @entity2670 was highest in females fed @entity2101 diet after 8 weeks, and @entity356 increased with the rise in fat at both protein levels in both sexes.(ABSTRACT TRUNCATED AT 400 WORDS)

title: Interaction of dietary fat and protein in spontaneous diseases of XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['Inflammation', 'inflammation']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic abscess', 'hepatic necrosis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['proliferative diseases']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['amyloidosis in the liver, kidneys']

entities_list: @entity11604 :: ('MESH:D009397', 'Disease') :: ['nephrocalcinosis']

entities_list: @entity329 :: ('10036', 'Species') :: ['Syrian golden hamsters']

entities_list: @entity2101 :: ('MESH:C538394', 'Disease') :: ['high-fat-high-protein', 'HF-HP']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian and hepatic ductal hyperplasia']

entities_list: @entity729 :: ('MESH:D061205', 'Disease') :: ['vascular calcification']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric and intestinal hyperplasia']

entities_list: @entity774 :: ('MESH:D000312', 'Disease') :: ['adrenal hyperplasia']

answer: @entity329 :: (10036,Species) :: ['Syrian golden hamsters']


abstract: PURPOSE: Biologic prostheses are designed to support tissue regeneration rather than just result in a strong scar plate, as is the case with synthetic mesh. It is not known if these newer materials will result in earlier return to normal activities and/or less post-herniorrhaphy groin @entity158 . METHOD/STUDY DESIGN: A prospective, randomized, controlled, third-party-blinded multicenter trial was designed to compare the use of a non-cross linked porcine dermis biologic graft [Strattice(TM) Reconstructive Tissue Matrix (RTM), LifeCell, Branchburg, NJ] versus light weight, large pore @entity7502 mesh (UltraPro(TM), Ethicon, Somerville, NJ). The study design called for recruitment of 170 @entity1 . These @entity1 are being followed for a minimum of 2  years. The primary aim of this study is to compare the safety and effectiveness of the two materials in a @entity169 as measured by resumption of activities of daily living. Secondary outcomes include @entity1118 , @entity260 and the incidence of re-herniation at 12 and 24  months. RESULTS: This paper discusses the study design, @entity1 recruitment and the current status of the clinical trial. The study involves nine medical centers, all with extensive experience in @entity547 repair. After 24  months of enrollment, 172 @entity1 were randomized and recruitment was then closed. All @entity1 underwent elective repair of primary unilateral @entity169 as an outpatient operation. Follow up data are being collected. Data analyses are scheduled at 3, 12, and 24  months postoperatively. CONCLUSION: We report the design of a multi-center, third-party blinded, randomized clinical trial comparing a new surgical device with existing technology in the repair of @entity169 . We believe this investigator-designed and conducted trial could serve as a model for similar trials examining surgical devices performed in collaboration with industry.

title: The design of an industry-sponsored randomized controlled trial to compare synthetic mesh versus biologic mesh for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity7502 :: ('MESH:D011126', 'Chemical') :: ['polypropylene']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity169 :: ('MESH:D006552', 'Disease') :: ['inguinal hernias', 'Lichtenstein inguinal hernia repair']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity169 :: (MESH:D006552,Disease) :: ['inguinal hernia repair']


abstract: BACKGROUND: Improvements in technology play an important role in caring for critically ill @entity1 . One example is the advance in ventilator design to facilitate triggering of mechanical breaths. Minimal changes in circuit flow unrelated to respiratory effort can trigger a ventilator breath and may mislead caregivers in recognizing @entity1620 . METHODS: We observed @entity1 with devastating @entity1545 in a mixed medical/surgical intensive care unit (ICU) with a high clinical suspicion for @entity1620 including the absence of cranial nerve function with apparent spontaneous breathing during @entity1 -triggered modes of mechanical ventilation. Further clinical observation for spontaneous respirations was assessed upon removal of ventilatory support. RESULTS: Nine @entity1 with @entity1545 due to multiple etiologies were identified and demonstrated no spontaneous respirations when formally assessed for @entity386 . Length of time between @entity1620 and its recognition could not be determined. CONCLUSION: When @entity1620 @entity1 who are suitable organ donors are mistakenly identified as having cerebral activity, the diagnosis of @entity1620 is delayed. This delay impacts resource utilization, impedes recovery and function of organs for donation, and adversely affects donor families, potential recipients of organs, and @entity1 donors who may have testing and treatment that cannot be beneficial. @entity1 with catastrophic @entity1545 and absent cranial nerve function should undergo immediate formal @entity386 testing.

title: Ventilator autocycling and delayed recognition of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1620 :: ('MESH:D001926', 'Disease') :: ['brain death', 'brain-dead']

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injuries', 'brain injury']

answer: @entity1620 :: (MESH:D001926,Disease) :: ['brain death']


abstract: BACKGROUND: Binge drinking is common in @entity1 adolescents. The adolescent brain is undergoing structural maturation and has a unique sensitivity to @entity167 @entity2359 . Therefore, adolescent binge @entity1068 may have long-term effects on the adult brain that alter brain structure and behaviors that are relevant to @entity167 -use disorders. METHODS: To determine whether adolescent @entity1068 (AE) binge drinking alters the adult brain, male C57BL/6 @entity19 were treated with either water or @entity1068 during adolescence (5 g/kg/d, i.g., postnatal days @entity22386 to @entity73066 ) and assessed during adulthood ( @entity19641 to P88). An array of neurotransmitter-specific genes, behavioral tests (i.e., reversal learning, prepulse inhibition, and open field), and postmortem brain structure using magnetic resonance imaging (MRI) and immunohistochemistry, were employed to assess persistent alterations in adult brain. RESULTS: At @entity1995 , 24 hours after AE binge, many neurotransmitter genes, particularly cholinergic and dopaminergic, were reduced by @entity1068 treatment. Interestingly, @entity935 receptor type 4 mRNA was reduced and confirmed using immunohistochemistry. Normal control maturation ( @entity1995 to P88) resulted in decreased neurotransmitter mRNA, e.g., an average decrease of 56%. Following AE treatment, adults showed greater gene expression reductions than controls, averaging 73%. Adult spatial learning assessed in the Morris water maze was not changed by AE treatment, but reversal learning experiments revealed deficits. Assessment of adult brain region volumes using MRI indicated that the olfactory bulb and basal forebrain were smaller in adults following AE. Immunohistochemical analyses found reduced basal forebrain area and fewer basal forebrain cholinergic neurons. CONCLUSIONS: Adolescent binge @entity1068 treatment reduces adult neurotransmitter gene expression, particularly cholinergic genes, reduces basal forebrain and olfactory bulb volumes, and causes a reduction in the density of basal forebrain @entity934 neurons. Loss of cholinergic neurons and forebrain structure could underlie adult reversal @entity4207 following adolescent binge drinking.

title: Adolescent binge drinking alters adult brain neurotransmitter gene expression, behavior, brain regional volumes, and neurochemistry in XXXX .

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['dopamine']

entities_list: @entity4207 :: ('MESH:D007859', 'Disease') :: ['learning deficits']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: Aortic proteoglycans (PG) were isolated from @entity1 aorta intima-media preparations with 4 M @entity2097 in the presence of protease inhibitors. The extracted PG mixture comprised 67% of the total aortic PG and was composed of 65% chondroitin @entity597 , 22% dermatan @entity597 , 8% heparan @entity597 , and 4% @entity17540 . Attempts at isolation and purification of PG monomers using isopycnic @entity6928 gradient centrifugation under associative and dissociative conditions resulted in appreciable loss of PG through associations with co-extracted aortic proteins. The addition of a gel chromatographic step on Sepharose CL-4B under dissociative conditions resulted in separation of PG from the majority of co-extracted proteins. In addition, the procedure resulted in a separation of the PG into a population ( @entity7597 ) eluting near the column V0 and one ( @entity39697 ) included with a Kav of 0.38. Hyaluronic acid co-eluted with @entity7597 . The major glycosaminoglycan in @entity7597 was chondroitin @entity597 , (85 to 95%). No dermatan @entity597 was detected in @entity7597 , but this glycosaminoglycan was the predominant glycosaminoglycan in @entity39697 (50 to 70%). Heparan @entity597 was present in small amounts in both @entity7597 and @entity39697 . Data presented support the proposal of at least three species of PG monomers in the aortic wall. Chromatographic studies under dissociative and associative conditions indicated that PG comprising @entity7597 but not @entity39697 were capable of associations with hyaluronic acid.

title: Isolation and preliminary characterization of proteoglycans dissociatively extracted from XXXX aorta.

entities_list: @entity17540 :: ('CHEBI:16336', 'Chemical') :: ['hyaluronate']

entities_list: @entity2097 :: ('MESH:D019791', 'Chemical') :: ['guanidine hydrochloride']

entities_list: @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The analysis of @entity3088 in unifloral honeys by high-performance liquid chromatography (HPLC) coupled with coulometric electrode array detection (CEAD) is described. The compounds were extracted by a nonionic polymeric resin (Amberlite XAD-2) and then separated on a reversed phase column using gradient elution. @entity3092 , @entity21119 , @entity24207 , @entity19812 , @entity15605 , @entity58010 , and @entity47593 were detected in a coulometric electrode array detection system between +300 and +800 mV against @entity11720 reference electrodes, and their presence was additionally confirmed by HPLC coupled with electrospray ionization mass spectrometry. The method was applied to analysis of 19 honeys of different varieties and origin. The limits of detection and quantitation ranged between 1.6 and 8.3  g/kg and 3.9 and 27.4  g/kg, respectively. The recoveries were above 96% in fluid and above 89% in creamy honeys. Some of these honeys ( @entity2487 , pumpkin, cherry blossom, dandelion, maple, and pine tree honey) were investigated for their @entity3096 content and profile for the first time. Differences between honeys were observed both in @entity3096 concentrations and in the @entity3096 profiles. The @entity3096 concentrations ranged from 0.015 to 3.4 mg/kg honey. @entity47593 , @entity15605 , @entity3092 , @entity58010 , and @entity19812 were detected in all investigated honeys, whereas @entity24207 occurred only in lemon and orange honeys and @entity21119 in lemon, orange, rhododendron, rosemary, and cherry blossom honeys.

title: Analysis of XXXX in honey by HPLC coupled with coulometric electrode array detection and electrospray ionization mass spectrometry.

entities_list: @entity21119 :: ('MESH:C005273', 'Chemical') :: ['naringenin']

entities_list: @entity47593 :: ('MESH:C037032', 'Chemical') :: ['Galangin', 'galangin']

entities_list: @entity24207 :: ('MESH:C013015', 'Chemical') :: ['hesperetin']

entities_list: @entity15605 :: ('MESH:C006552', 'Chemical') :: ['kaempferol']

entities_list: @entity58010 :: ('MESH:C047368', 'Chemical') :: ['isorhamnetin']

entities_list: @entity11720 :: ('MESH:D010165', 'Chemical') :: ['palladium']

entities_list: @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids']

entities_list: @entity3092 :: ('MESH:D011794', 'Chemical') :: ['quercetin', 'Quercetin']

entities_list: @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid']

answer: @entity3088 :: (MESH:D005419,Chemical) :: ['flavonoids']


abstract: PURPOSE: to evaluate the biological and clinical implications of @entity854 of bone marrow myeloid cell compartment in @entity1 with primary @entity2590 ( @entity2590 ). METHODS: analysis of @entity3058 profiles was performed by flow cytometric immunophenotyping on bone marrow mononuclear cell (BMMNCs) specimens from 39 adult @entity2590 @entity1 and 5 healthy individuals. Expression of @entity3058 profiles was correlated with @entity13352 subtype, cytogenetics, CFU-GM colony growth, @entity1349 ( @entity1349 ) and leukemic transformation (LT). RESULTS: expression levels of early differentiation and myelo-monocytic antigens ( @entity3053 , @entity10793 , @entity1116 , @entity5750 and @entity5824 ) on myeloid cell compartment of BMMCs were significantly higher in @entity2590 @entity1 in comparison to healthy control group, suggesting maturational left shift of bone marrow myeloid cell compartment in @entity2590 . @entity2280 antigen expression was in a positive linear correlation with HLA-DR antigen expression (r=0.652; p=0.0004), and in negative correlation with the expression of @entity9536 and @entity5824 antigens (r=-0.48; p=0.014 and r=-0.564; p=0.0033, respectively). Myeloid antigen ratio (HLA-DR/ @entity9536 ) was 2.5 fold higher in @entity1 with @entity2590 in comparison to control group. @entity1 with @entity1442 had significantly higher myeloid antigen ratio than @entity1 with low risk @entity2590 (p<0.05). The type of CFU-GM colony growth and the presence of chromosomal aberrations were unrelated to the proportion of @entity2280 (+) cells and elevated myeloid ratio. @entity1 with elevated proportion of @entity2280 (+) BMMNCs or elevated myeloid ratio had significantly shorter @entity1349 and higher LT rate in comparison to @entity1 whose proportion of @entity2280 (+) BMMNCs and myeloid ratio were within normal range. CONCLUSION: the presence of abnormalities in antigen expression profiles of bone marrow myeloid cell compartment has clinical implication in @entity2590 , with particular contribution in predicting the @entity1 outcome. Elevated proportion of @entity2280 (+) BMMNCs and elevated myeloid ratio of bone marrow myeloid compartment are useful immunophenotypic tools for estimation of prognosis in this very heterogeneous disorder group.

title: Clinical implications of XXXX of bone marrow myeloid cell compartment in @entity2590 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity3058 :: ('963', 'Gene') :: ['cell surface antigen']

entities_list: @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndromes', 'MDS']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['immunophenotypic abnormalities']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity854 :: (MESH:D018376,Disease) :: ['immunophenotypic abnormalities']


abstract: PURPOSE: to evaluate the biological and clinical implications of @entity854 of bone marrow myeloid cell compartment in @entity1 with primary @entity2590 ( @entity2590 ). METHODS: analysis of @entity3058 profiles was performed by flow cytometric immunophenotyping on bone marrow mononuclear cell (BMMNCs) specimens from 39 adult @entity2590 @entity1 and 5 healthy individuals. Expression of @entity3058 profiles was correlated with @entity13352 subtype, cytogenetics, CFU-GM colony growth, @entity1349 ( @entity1349 ) and leukemic transformation (LT). RESULTS: expression levels of early differentiation and myelo-monocytic antigens ( @entity3053 , @entity10793 , @entity1116 , @entity5750 and @entity5824 ) on myeloid cell compartment of BMMCs were significantly higher in @entity2590 @entity1 in comparison to healthy control group, suggesting maturational left shift of bone marrow myeloid cell compartment in @entity2590 . @entity2280 antigen expression was in a positive linear correlation with HLA-DR antigen expression (r=0.652; p=0.0004), and in negative correlation with the expression of @entity9536 and @entity5824 antigens (r=-0.48; p=0.014 and r=-0.564; p=0.0033, respectively). Myeloid antigen ratio (HLA-DR/ @entity9536 ) was 2.5 fold higher in @entity1 with @entity2590 in comparison to control group. @entity1 with @entity1442 had significantly higher myeloid antigen ratio than @entity1 with low risk @entity2590 (p<0.05). The type of CFU-GM colony growth and the presence of chromosomal aberrations were unrelated to the proportion of @entity2280 (+) cells and elevated myeloid ratio. @entity1 with elevated proportion of @entity2280 (+) BMMNCs or elevated myeloid ratio had significantly shorter @entity1349 and higher LT rate in comparison to @entity1 whose proportion of @entity2280 (+) BMMNCs and myeloid ratio were within normal range. CONCLUSION: the presence of abnormalities in antigen expression profiles of bone marrow myeloid cell compartment has clinical implication in @entity2590 , with particular contribution in predicting the @entity1 outcome. Elevated proportion of @entity2280 (+) BMMNCs and elevated myeloid ratio of bone marrow myeloid compartment are useful immunophenotypic tools for estimation of prognosis in this very heterogeneous disorder group.

title: Clinical implications of @entity854 of bone marrow myeloid cell compartment in XXXX .

answer: @entity2590 :: (MESH:D009190,Disease) :: ['myelodysplastic syndromes']


abstract: The effects of long-term (10 years) management at a special out- @entity1 @entity101 clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and @entity65 have been studied in 686 middle-aged male @entity101 . The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The @entity101 @entity1 were derived from a random sample of @entity1 , aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of @entity1 , but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the @entity1 achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney ( @entity633 , serum @entity1011 ) involvement remained unchanged or increased slightly during follow-up. @entity951 ( @entity951 ), @entity613 ( @entity613 ) and @entity712 ( @entity712 ) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% ( @entity951 ), 0.6% ( @entity613 ) and 0.6% ( @entity712 ). ECG signs indicating subclinical @entity299 were risk factor for @entity951 and @entity712 . Smoking was an independent risk factor for any one of these @entity65 . The 10-year incidence of total mortality was 11.1%, and of CHD and @entity64 morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum @entity165 , @entity951 and @entity644 . A previous @entity64 , smoking and @entity644 were independently associated with @entity64 morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)

title: XXXX in middle-aged @entity1 . Management, morbidity and prognostic factors during long-term @entity101 care.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure', 'CHF']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensives', 'hypertension', 'hypertensive']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria']

entities_list: @entity951 :: ('MESH:D000787', 'Disease') :: ['Angina pectoris', 'AP']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['intermittent claudication', 'IC']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disorders', 'cardiovascular morbidity']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertension']


abstract: The effects of long-term (10 years) management at a special out- @entity1 @entity101 clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and @entity65 have been studied in 686 middle-aged male @entity101 . The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The @entity101 @entity1 were derived from a random sample of @entity1 , aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of @entity1 , but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the @entity1 achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney ( @entity633 , serum @entity1011 ) involvement remained unchanged or increased slightly during follow-up. @entity951 ( @entity951 ), @entity613 ( @entity613 ) and @entity712 ( @entity712 ) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% ( @entity951 ), 0.6% ( @entity613 ) and 0.6% ( @entity712 ). ECG signs indicating subclinical @entity299 were risk factor for @entity951 and @entity712 . Smoking was an independent risk factor for any one of these @entity65 . The 10-year incidence of total mortality was 11.1%, and of CHD and @entity64 morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum @entity165 , @entity951 and @entity644 . A previous @entity64 , smoking and @entity644 were independently associated with @entity64 morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)

title: @entity101 in middle-aged @entity1 . Management, morbidity and prognostic factors during long-term XXXX care.

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: The effects of long-term (10 years) management at a special out- @entity1 @entity101 clinic with respect to dropout rate, side effects, blood pressure (BP) control, target organ involvement, prognostic factors and @entity65 have been studied in 686 middle-aged male @entity101 . The impact of antihypertensive treatment, as one ingredient of multiple risk factor intervention, on mortality and morbidity in an urban, male population have been analysed. The @entity101 @entity1 were derived from a random sample of @entity1 , aged 47-54 years at entry, constituting the intervention group (n = 7,455) of a multifactorial primary prevention trail. The whole population sample was studied regarding the effect of treatment on morbidity. The 10-year drop-out rate (declined follow-up/unknown reasons) was low (5%) being highest during the first year. The frequency of severe adverse drug effects was low (3% per year) after the initial period when treatment was started. An acceptable BP reduction was achieved in the majority of @entity1 , but in many cases first after a few years' treatment and requiring combination drug therapy. Two-thirds of the @entity1 achieved the goal BP (i.e. less than 160/95 mm Hg). These results are attributed to the organisation of the clinic and emphasise the need for frequent check-ups during the early phase of treatment and an easy accessibility to nurses and physicians. Except for a significant regression of ST- and T-wave changes on the conventional ECG during the first treatment year signs of heart (conventional ECG, chest X-ray) and kidney ( @entity633 , serum @entity1011 ) involvement remained unchanged or increased slightly during follow-up. @entity951 ( @entity951 ), @entity613 ( @entity613 ) and @entity712 ( @entity712 ) were common complications. The prevalence increased steadily with an average annual incidence of 1.3% ( @entity951 ), 0.6% ( @entity613 ) and 0.6% ( @entity712 ). ECG signs indicating subclinical @entity299 were risk factor for @entity951 and @entity712 . Smoking was an independent risk factor for any one of these @entity65 . The 10-year incidence of total mortality was 11.1%, and of CHD and @entity64 morbidity 12.2% and 4.1%, respectively. Independent risk factors (entry variables) for CHD were diastolic BP, smoking, serum @entity165 , @entity951 and @entity644 . A previous @entity64 , smoking and @entity644 were independently associated with @entity64 morbidity. Hence, the risk factor pattern was similar to that known to operate in the general population.(ABSTRACT TRUNCATED AT 400 WORDS)

title: @entity101 in middle-aged XXXX . Management, morbidity and prognostic factors during long-term @entity101 care.

answer: @entity1 :: (9606,Species) :: ['men']


abstract: Tamm-Horsfall protein ( @entity7312 ) is a glycoprotein expressed exclusively in thick ascending limbs (TAL) of the kidney. We recently described a novel protective role of @entity7312 against @entity810 ( @entity810 ) via downregulation of @entity32 in the outer medulla. Our current study investigates the mechanistic relationships among the status of @entity7312 , @entity32 , and @entity810 . Using an @entity63 -reperfusion model in wild-type and @entity7312 -/- @entity19 , we demonstrate that it is the S3 proximal segments but not the @entity7312 -deficient TAL that are the main targets of @entity810 during @entity810 . The injured S3 segments that are surrounded by neutrophils in @entity7312 -/- @entity19 have marked overexpression of neutrophil chemoattractant @entity9701 compared with wild-type counterparts. Neutralizing @entity9701 ( @entity9701 ) antibody rescues S3 segments from injury, decreases neutrophil infiltration, and improves kidney function in @entity7312 -/- @entity19 . Furthermore, using immunofluorescence volumetric imaging of wild-type @entity19 kidneys, we show that @entity63 alters the intracellular translocation of @entity7312 in the TAL cells by partially shifting it from its default apical surface domain to the basolateral domain, the latter being contiguous to the basolateral surface of S3 segments. Concomitant with this is the upregulation, in the basolateral surface of S3 segments, of the scavenger receptor @entity25694 , a putative receptor for @entity7312 . We conclude that @entity48353 affects the susceptibility of S3 segments to injury at least in part by regulating @entity9701 expression in a @entity7312 -dependent manner. Our findings raise the interesting possibility of a direct role of basolaterally released @entity7312 on regulating @entity32 in S3 segments.

title: Tamm-Horsfall protein-deficient thick ascending limbs promote injury to neighboring S3 segments in an XXXX -dependent mechanism.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity9701 :: ('20310(Tax:10090)', 'Gene') :: ['MIP-2', 'macrophage inflammatory protein-2']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['AKI', 'acute kidney injury', 'tubular injury']

answer: @entity9701 :: (20310(Tax:10090),Gene) :: ['MIP-2']


abstract: Nontuberculous mycobacteria rarely infect the central nervous system. Recently, Mycobacterium genavense, nontuberculous mycobacterium (NTM), has been identified as a significant pathogen in @entity1 . In this report, we describe multiple @entity1504 caused by M. genavense in an immunocompromised host. A 50-year-old @entity1 presented with @entity4653 , @entity2026 , and @entity1269 . He had a @entity465 and a M. genavense @entity281 in the thoracic and abdominal lymph nodes. Magnetic resonance imaging revealed multiple intracranial masses in the subcortical regions with extensive perifocal @entity4 . Laboratory investigations and cultures of cerebrospinal fluid provided no evidence of disseminated @entity281 . We obtained a biopsy sample via a small craniotomy using neuronavigation, and NTM @entity281 was confirmed on analysis of the specimen. He was treated with antimycobacterial agents, and the clinical symptoms and radiological findings improved. Although a surgical procedure bears the potential risk of @entity281 , especially in an immunocompromised @entity1 , a brain biopsy was necessary for definitive diagnosis in this case and it aided in the administration of appropriate treatment.

title: [Multiple infectious XXXX of Mycobacterium genavense in an immunocompromised @entity1 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['right hemiparesis']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial lesions']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['primary immunodeficiency']

entities_list: @entity4653 :: ('MESH:D004401', 'Disease') :: ['dysarthria']

answer: @entity1504 :: (MESH:D002561,Disease) :: ['intracranial lesions']


abstract: Nontuberculous mycobacteria rarely infect the central nervous system. Recently, Mycobacterium genavense, nontuberculous mycobacterium (NTM), has been identified as a significant pathogen in @entity1 . In this report, we describe multiple @entity1504 caused by M. genavense in an immunocompromised host. A 50-year-old @entity1 presented with @entity4653 , @entity2026 , and @entity1269 . He had a @entity465 and a M. genavense @entity281 in the thoracic and abdominal lymph nodes. Magnetic resonance imaging revealed multiple intracranial masses in the subcortical regions with extensive perifocal @entity4 . Laboratory investigations and cultures of cerebrospinal fluid provided no evidence of disseminated @entity281 . We obtained a biopsy sample via a small craniotomy using neuronavigation, and NTM @entity281 was confirmed on analysis of the specimen. He was treated with antimycobacterial agents, and the clinical symptoms and radiological findings improved. Although a surgical procedure bears the potential risk of @entity281 , especially in an immunocompromised @entity1 , a brain biopsy was necessary for definitive diagnosis in this case and it aided in the administration of appropriate treatment.

title: [Multiple infectious @entity1504 of Mycobacterium genavense in an immunocompromised XXXX ].

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: OBJECTIVE: Cross-sectional studies suggest an association between hysterectomy and negative affect. Using prospective data, we examined the associations of negative affect, attitudes toward aging and menopause, @entity1109 , and vasomotor symptoms with elective hysterectomy in midlife. METHODS: Data were from the Study of @entity1 's Health Across the Nation, a multisite, community-based prospective cohort study of the menopausal transition (n = 2,818). Annually reported hysterectomy at visits 2 to 9 was verified with medical records when available (71%). @entity148 , perceived stress, @entity308 , attitudes toward aging and menopause, vasomotor symptoms, and @entity1109 were assessed at baseline using standardized questions. Cox proportional hazards models were used to relate these variables to subsequent elective hysterectomy. Covariates included demographic variables, @entity548 , body mass index, hormone levels, and self-rated health, also assessed at baseline. RESULTS: Elective hysterectomy was reported by 6% (n = 168) of @entity1 over an 8-year period. @entity1 with hysterectomy were not higher in negative affect or negative attitudes toward aging and menopause compared with @entity1 without hysterectomy. Vasomotor symptoms (hazard ratio [HR], 1.44; 95% CI, 1.03-2.01; P = 0.03) and positive attitudes toward aging and menopause (HR, 1.74; 95% CI, 1.04-2.93) at baseline predicted hysterectomy over the 8-year period, controlling for @entity548 , site, race/ethnicity, follicle-stimulating hormone, age, education, body mass index, and self-rated health. @entity548 at baseline were the strongest predictor of hysterectomy (HR, 4.30; 95% CI, 2.05-9.05). CONCLUSIONS: In this prospective examination, negative affect and attitudes were not associated with subsequent hysterectomy. @entity548 were the major determinant of elective hysterectomy.

title: Negative attitudes and affect do not predict elective hysterectomy: a prospective analysis from the Study of XXXX 's Health Across the Nation.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['menstrual bleeding problems', 'Menstrual bleeding problems']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['premenstrual symptoms']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: OBJECTIVE: We wanted to compare the two-dimensional (2D) fast spin echo (FSE) techniques and the three-dimensional (3D) fast field echo techniques for the evaluation of the @entity18826 using a microscopy coil. MATERIALS AND METHODS: Twenty five @entity1 who underwent total knee arthroplasty were included in this study. Preoperative MRI evaluation of the patella was performed using a microscopy coil (47 mm). The proton density-weighted fast spin echo images ( @entity1726 ), the fat-suppressed @entity1726 images (FS- @entity1726 ), the intermediate weighted-fat suppressed fast spin echo images (iw-FS-FSE), the 3D balanced-fast field echo images (B-FFE), the 3D water selective cartilage scan (WATS-c) and the 3D water selective fluid scan (WATS-f) were obtained on a 1.5T MRI scanner. The patellar cartilage was evaluated in nine areas: the superior, middle and the inferior portions that were subdivided into the medial, central and lateral facets in a total of 215 areas. Employing the Noyes grading system, the MRI grade 0-I, II and III lesions were compared using the gross and microscopic findings. The sensitivity, specificity and accuracy were evaluated for each sequence. The significance of the differences for the individual sequences was calculated using the McNemar test. RESULTS: The gross and microscopic findings demonstrated 167 grade 0-I lesions, 40 @entity75 and eight @entity75 . Iw-FS-FSE had the highest accuracy (sensitivity/specificity/accuracy = 88%/98%/96%), followed by FS- @entity1726 (78%/98%/93%, respectively), @entity1726 (76%/98%/93%, respectively), B-FFE (71%/100%/93%, respectively), WATS-c (67%/100%/92%, respectively) and WATS-f (58%/99%/89%, respectively). There were statistically significant differences for the iw-FS-FSE and WATS-f and for the @entity1726 -FS and WATS-f (p < 0.01). CONCLUSION: The iw-FS-FSE images obtained with a microscopy coil show best diagnostic performance among the 2D and 3D GRE images for evaluating the @entity18826 .

title: Evaluation of the XXXX using a microscopy coil: comparison of the two-dimensional fast spin echo techniques and the three-dimensional fast field echo techniques.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity18826 :: ('MESH:D046789', 'Disease') :: ['chondromalacia patella']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['grade II lesions', 'grade III lesions']

answer: @entity18826 :: (MESH:D046789,Disease) :: ['chondromalacia patella']


abstract: At defined coronal sections, the surface area of infarcted tissue was measured 4 days after the occlusion of the middle artery in 11 @entity468 . In groups of @entity468 treated with @entity4320 (5.6 and 16.7 microgram/kg . min over 3 h. 5 min after the occlusion), the infarcted surface was significantly decreased. The topographic localization of the @entity1188 was studied in control and treated @entity468 . This established @entity39 was correlated with measures of focal cerebral blood flow and @entity413 consumption 3.5 h after the @entity2500 . Grey matter blood flow was universally low in untreated @entity468 , but in @entity468 treated with @entity4320 (5.6 microgram/kg . min) cortical and caudate nucleus blood flow was 2-3 times greater, even in those regions that were later infarcted in the treated @entity468 . @entity413 consumption was similarly reduced in untreated @entity468 but there was little difference between the control and drug-treated @entity468 except in some areas where drug treatment appeared to further reduce the values for focal @entity413 consumption. These regions correlated with those in which @entity1188 was later found in the @entity468 treated with @entity4320 . It is hoped that such correlations between pathology. flow and metabolism could help the search for effective pharmacotherapy of @entity66 .

title: Correlation of local blood flow, XXXX consumption and probability of @entity39 following a @entity2500 in the cat.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity2500 :: ('MESH:D020244', 'Disease') :: ['middle cerebral artery occlusion']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity4320 :: ('MESH:C010739', 'Chemical') :: ['ifenprodil']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: At defined coronal sections, the surface area of infarcted tissue was measured 4 days after the occlusion of the middle artery in 11 @entity468 . In groups of @entity468 treated with @entity4320 (5.6 and 16.7 microgram/kg . min over 3 h. 5 min after the occlusion), the infarcted surface was significantly decreased. The topographic localization of the @entity1188 was studied in control and treated @entity468 . This established @entity39 was correlated with measures of focal cerebral blood flow and @entity413 consumption 3.5 h after the @entity2500 . Grey matter blood flow was universally low in untreated @entity468 , but in @entity468 treated with @entity4320 (5.6 microgram/kg . min) cortical and caudate nucleus blood flow was 2-3 times greater, even in those regions that were later infarcted in the treated @entity468 . @entity413 consumption was similarly reduced in untreated @entity468 but there was little difference between the control and drug-treated @entity468 except in some areas where drug treatment appeared to further reduce the values for focal @entity413 consumption. These regions correlated with those in which @entity1188 was later found in the @entity468 treated with @entity4320 . It is hoped that such correlations between pathology. flow and metabolism could help the search for effective pharmacotherapy of @entity66 .

title: Correlation of local blood flow, @entity413 consumption and probability of XXXX following a @entity2500 in the cat.

answer: @entity39 :: (MESH:D009336,Disease) :: ['necrosis']


abstract: At defined coronal sections, the surface area of infarcted tissue was measured 4 days after the occlusion of the middle artery in 11 @entity468 . In groups of @entity468 treated with @entity4320 (5.6 and 16.7 microgram/kg . min over 3 h. 5 min after the occlusion), the infarcted surface was significantly decreased. The topographic localization of the @entity1188 was studied in control and treated @entity468 . This established @entity39 was correlated with measures of focal cerebral blood flow and @entity413 consumption 3.5 h after the @entity2500 . Grey matter blood flow was universally low in untreated @entity468 , but in @entity468 treated with @entity4320 (5.6 microgram/kg . min) cortical and caudate nucleus blood flow was 2-3 times greater, even in those regions that were later infarcted in the treated @entity468 . @entity413 consumption was similarly reduced in untreated @entity468 but there was little difference between the control and drug-treated @entity468 except in some areas where drug treatment appeared to further reduce the values for focal @entity413 consumption. These regions correlated with those in which @entity1188 was later found in the @entity468 treated with @entity4320 . It is hoped that such correlations between pathology. flow and metabolism could help the search for effective pharmacotherapy of @entity66 .

title: Correlation of local blood flow, @entity413 consumption and probability of @entity39 following a XXXX in the cat.

answer: @entity2500 :: (MESH:D020244,Disease) :: ['middle cerebral artery occlusion']


abstract: BACKGROUND: Our objective was to evaluate the accuracy of @entity65 ( @entity65 ) risk score classification by direct LDL @entity165 (dLDL-C), calculated LDL @entity165 (cLDL-C), and non-HDL @entity165 (non-HDL-C) compared to classification by reference measurement procedures (RMPs) performed at the CDC. METHODS: We examined 175 individuals, including 138 with @entity65 or conditions that may affect LDL-C measurement. dLDL-C measurements were performed using Denka, Kyowa, Sekisui, Serotec, Sysmex, UMA, and Wako reagents. cLDL-C was calculated by the Friedewald equation, using each manufacturer's direct HDL-C assay measurements, and total @entity165 and @entity412 measurements by Roche and @entity5377 (Advia) assays, respectively. RESULTS: For @entity1 with @entity1674 <2.26 mmol/L (<200 mg/dL), the overall misclassification rate for the @entity65 risk score ranged from 5% to 17% for cLDL-C methods and 8% to 26% for dLDL-C methods when compared to the RMP. Only Wako dLDL-C had fewer misclassifications than its corresponding cLDL-C method (8% vs 17%; P<0.05). Non-HDL-C assays misclassified fewer @entity1 than dLDL-C for 4 of 8 methods (P<0.05). For @entity1 with @entity1674 >= 2.26 mmol/L (>= 200 mg/dL) and<4.52 mmol/L (<400 mg/dL), dLDL-C methods, in general, performed better than cLDL-C methods, and non-HDL-C methods showed better correspondence to the RMP for @entity65 risk score than either dLDL-C or cLDL-C methods. CONCLUSIONS: Except for @entity6308 individuals, 7 of 8 dLDL-C methods failed to show improved @entity65 risk score classification over the corresponding cLDL-C methods. Non-HDL-C showed overall the best concordance with the RMP for @entity65 risk score classification of both normal and @entity6308 individuals.

title: Non-HDL XXXX shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL @entity165 in a dyslipidemic population.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity6308 :: ('MESH:D064250', 'Disease') :: ['hypertriglyceridemic']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']


abstract: BACKGROUND: Our objective was to evaluate the accuracy of @entity65 ( @entity65 ) risk score classification by direct LDL @entity165 (dLDL-C), calculated LDL @entity165 (cLDL-C), and non-HDL @entity165 (non-HDL-C) compared to classification by reference measurement procedures (RMPs) performed at the CDC. METHODS: We examined 175 individuals, including 138 with @entity65 or conditions that may affect LDL-C measurement. dLDL-C measurements were performed using Denka, Kyowa, Sekisui, Serotec, Sysmex, UMA, and Wako reagents. cLDL-C was calculated by the Friedewald equation, using each manufacturer's direct HDL-C assay measurements, and total @entity165 and @entity412 measurements by Roche and @entity5377 (Advia) assays, respectively. RESULTS: For @entity1 with @entity1674 <2.26 mmol/L (<200 mg/dL), the overall misclassification rate for the @entity65 risk score ranged from 5% to 17% for cLDL-C methods and 8% to 26% for dLDL-C methods when compared to the RMP. Only Wako dLDL-C had fewer misclassifications than its corresponding cLDL-C method (8% vs 17%; P<0.05). Non-HDL-C assays misclassified fewer @entity1 than dLDL-C for 4 of 8 methods (P<0.05). For @entity1 with @entity1674 >= 2.26 mmol/L (>= 200 mg/dL) and<4.52 mmol/L (<400 mg/dL), dLDL-C methods, in general, performed better than cLDL-C methods, and non-HDL-C methods showed better correspondence to the RMP for @entity65 risk score than either dLDL-C or cLDL-C methods. CONCLUSIONS: Except for @entity6308 individuals, 7 of 8 dLDL-C methods failed to show improved @entity65 risk score classification over the corresponding cLDL-C methods. Non-HDL-C showed overall the best concordance with the RMP for @entity65 risk score classification of both normal and @entity6308 individuals.

title: Non-HDL @entity165 shows improved accuracy for cardiovascular risk score classification compared to direct or calculated LDL XXXX in a dyslipidemic population.

answer: @entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']


abstract: BACKGROUND: Posttransplant survival in heart transplant recipients has progressively improved during the past 2 decades. It is unknown, however, whether the major racial groups in the United States have benefited equally. METHODS AND RESULTS: We analyzed all primary heart transplant recipients aged >= 18 years in the United States from 1987 to 2008. We compared posttransplant survival in white, black, and Hispanic recipients in 5 successive eras (1987 to 1992, 1993 to 1996, 1997 to 2000, 2001 to 2004, 2005 to 2008). Early survival was defined as freedom from death or retransplantation during the first 6 months posttransplant. Longer-term, conditional survival was assessed in @entity1 who survived the first 6 months. There were 29 986 (81.6%) white, 4745 (12.9%) black, and 2017 (5.5%) Hispanic @entity1 in the study cohort. Black @entity1 were at increased risk of @entity204 or retransplant (hazard ratio [HR], 1.15; 95% CI, 1.05 to 1.26) in adjusted analysis. Early posttransplant survival improved (HR, 0.83; 95% CI, 0.80 to 0.87 for successive eras) equally in all 3 groups (black- @entity7971 interaction, P=0.94; Hispanic- @entity7971 interaction, P=0.40). Longer-term survival improved in white (HR, 0.95; 95% CI, 0.92 to 0.97 for successive eras) but not in black (HR, 1.04; 95% CI, 0.99 to 1.09) or Hispanic (HR, 1.02; 95% CI, 0.95 to 1.09) recipients, resulting in increased disparities in longer-term survival with time. CONCLUSIONS: Early posttransplant survival has improved equally in white, black, and Hispanic heart transplant recipients. Longer-term survival has improved in white but not in black or Hispanic recipients, resulting in a more marked disparity in outcomes in the current @entity7971 . These disparities warrant further investigation and targeted interventions.

title: Improved survival in heart transplant recipients in the United States: racial differences in XXXX effect.

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['early death']

answer: @entity7971 :: (26284,Gene) :: ['era']


abstract: PURPOSE: @entity792 is a sight-threatening disease in which autoreactive T cells cross the blood-retinal barrier. Molecular mechanisms contributing to the @entity1200 in this @entity792 are not well understood. In this study, the authors investigated the changes in the matrix metalloproteinase network in spontaneous @entity1596 . METHODS: Matrix metalloproteinase (MMP) @entity37288 , @entity37289 , and @entity73067 expression and @entity44265 and @entity73068 ( @entity73068 ) expression were analyzed using Western blot quantification. Enzyme activities were examined with zymography. Expression patterns of network candidates were revealed with immunohistochemistry, comparing physiological appearance and changes in a spontaneous recurrent @entity1596 model. RESULTS: @entity44265 protein expression was found to be decreased in both the vitreous and the retina of a spontaneous model for @entity792 ( @entity1641 recurrent @entity1596 [ERU]), and @entity44265 activity was significantly reduced in ERU vitreous. Functionally associated MMPs such as @entity37288 , @entity73067 , and @entity37289 were found to show altered or shifted expression and activity. Although @entity37288 decreased in ERU vitreous, @entity37289 expression and activity were found to be increased. These changes were reflected by profound changes within uveitic target tissue, where @entity44265 , @entity37289 , and @entity73067 decreased in expression, whereas @entity37288 displayed a shifted expression pattern. @entity73068 , a potential stabilizer of @entity37289 , was found prominently expressed in @entity1641 healthy retina and displayed notable changes in expression patterns accompanied by significant upregulation in autoimmune conditions. Invading cells expressed @entity37289 and @entity73068 . CONCLUSIONS: This study implicates a dysregulation or a change in functional protein-protein interactions in this @entity44265 -associated protein network, together with altered expression of functionally related MMPs.

title: Changes in matrix metalloproteinase network in a spontaneous XXXX model.

entities_list: @entity1200 :: ('MESH:D007154', 'Disease') :: ['loss of eye immune privilege']

entities_list: @entity44265 :: ('100034134(Tax:9796)', 'Gene') :: ['tissue inhibitor of metalloproteinase (TIMP)-2', 'TIMP2']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune uveitis', 'autoimmune disease', 'Autoimmune uveitis']

answer: @entity792 :: (MESH:D001327,Disease) :: ['autoimmune uveitis']


abstract: STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the incidence of @entity177 after anterior screw fixation of type II and rostral shallow @entity174 and to identify related risk factors. SUMMARY OF BACKGROUND DATA: Although several studies have reported fusion rates after anterior odontoid screw fixation of type II and rostral shallow @entity174 , few reports have analyzed in detail the risk factors associated with @entity177 . METHODS: Forty-one @entity1 with a type II and rostral shallow type III odontoid @entity174 were treated using anterior screw fixation. The @entity1 were 33 @entity1 and 8 @entity1 mean age = 46.6 years; age range = 15-79 years. Range of follow-up was 7 to 48 months. RESULTS: Anterior odontoid screw fixation resulted in solid bony union in 33 @entity1 (80.5%), fibrous union in 3 (7.3%), and nonunion in 5 (12.2%). When surgery was delayed for more than 1 week, the incidence of @entity177 significantly increased (P = 0.0051). Furthermore, a @entity174 gap of 2 mm or more was found to be significantly associated with @entity177 (P = 0.0172). However, @entity1 age and @entity174 were not found to be significantly associated with @entity177 (P = 0.8236 and P = 0.5762, respectively). CONCLUSION: Our study of anterior odontoid screw fixation reveals that the risk of @entity177 is 37.5 times greater in @entity1 with a delay of more than 1 week before operation, and 21 times greater in @entity1 with a @entity174 gap of greater than 2 mm.

title: Analysis of risk factors associated with XXXX after anterior odontoid screw fixation.

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['fusion failure']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['type III fractures', 'fracture', 'fracture displacement']

answer: @entity177 :: (MESH:D051437,Disease) :: ['fusion failure']


abstract: Fundamental and clinical studies were carried out on @entity8933 suppository (CZX-S), and the following results were obtained in pediatrics. In 4 @entity1 of the CZX-S 125 mg-administered group (9.4-9.9 mg/kg), the serum concentration of CZX reached a peak of 5.55 micrograms/ml on the average, 30 minutes after dosing, i.e. at the time of initial blood collection, and decreased gradually to 0.20 microgram/ml 6 hours after dosing. The half-life was 1.09 hours. In 5 @entity1 of the CZX-S 250 mg-administered group (8.4-18.1 mg/kg), the serum concentration of CZX peaked at 7.07 micrograms/ml on the average and then gradually declined to 0.16 microgram/ml 6 hours after dosing. The half-life was 1.00 hour. The urinary recovery rate varied as widely as 6.5-38.0% in all the @entity1 of both groups. CZX-S was given to total 19 @entity1 ; 8 @entity1 with @entity293 ( @entity293 ), 3 with @entity7551 or @entity5389 , 4 with @entity3617 , 2 with @entity55 , 1 with @entity2346 media and 1 with staphylococcal scalding @entity272 . The overall effect of CZX-S in 15 @entity1 was "effective" or better response, with an effectiveness rate of 83.3%, except one who discontinued the drug because of side effects. CZX-S was given to most of the @entity1 weighing 15 kg or higher in a dose of 250 mg 3-4 times a day and frequently to @entity1 weighing less than 15 kg in a dose of 125 mg 3-4 times a day. As to side effects, slight @entity294 was encountered in 1 @entity1 . Laboratory examinations disclosed an increase in GOT in 1 @entity1 , which returned to normal after continual insertion of the suppository.

title: [Fundamental and clinical studies of XXXX suppositories in pediatrics].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3617 :: ('MESH:D001991', 'Disease') :: ['bronchitis']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity7551 :: ('MESH:D010612', 'Disease') :: ['pharyngitis']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity5389 :: ('MESH:D014069', 'Disease') :: ['tonsillitis']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin syndrome']

entities_list: @entity8933 :: ('MESH:D015296', 'Chemical') :: ['ceftizoxime']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection', 'UTI']

answer: @entity8933 :: (MESH:D015296,Chemical) :: ['ceftizoxime']


abstract: A retrospective analysis of 3052 gastroscopies made by our Digestive Endoscopy Department from 1974 to 1979 was carried out. 14 Early @entity356 out of a total of 157 @entity356 were diagnosed (8.9%), with an EGC: Gastroscopies ratio = 1:218. From the macroscopic point of view 8 were found to belong to type III, 5 to type II, and 1 to type I. The main location was the lesser curvature (angulus-antrum). With regard to the degree of infiltration, 2 were found to belong to stage 0a, 8 to stage 0b, and 5 to stage I. The endoscopic observation gave reason to suspect the presence of a @entity5 in 6 of the 14 cases. The bioptic examination proved positive in 10 cases, while in 4 the diagnosis was made on the operatory piece. The importance of multiple bioptic samples is again confirmed. Cytology performed by brushing showed malignant tumoral cells in 4 cases, and again in 4 cases the radiological examination led to suspicion of @entity2275 . 13 @entity1 were subjected to surgery during which no metastases to the locoregional lymphonodes were found; the @entity1 are all alive. We started @entity356 screening by selecting the @entity1 on the basis of a worksheet covering epidemiological, clinical, biohumoural and instrumental parameters, since the prognosis for the disease is directly proportional to the earliness of its diagnosis.

title: [Early XXXX : a retrospective study of our cases (1974-1979)].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant lesion']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma', 'Gastric Cancers', 'gastric carcinomas']

entities_list: @entity2275 :: ('MESH:D013276', 'Disease') :: ['degenerated gastric ulcer']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']