abstract: INTRODUCTION: In blunt @entity1661 , lesions of the small bowell and mesentery are often underdiagnosed; although unusual, they represent the third most injured organ, with increasing morbidity and mortality. PRESENTATION OF CASE: The authors present the case of a 68 years old male, admitted to the emergency department after being hit by a bale of straw, weighing around 300kg, in the abdomen. After successful ressuscitation, a CT scan was performed, suggesting hemoperitoneum because of vascular lesion of the right colon @entity548 . An exploratory laparotomy was performed, confirming the presence of blood in the abdominal cavity and identifying jejunal perforation, an apparently innocent @entity1410 of the small bowel mesentery (beside the bowel wall) distally to the first lesion and a laceration of the sigmoid serosa; a segmental jejunal resection and suture of the colon serosa were performed. In the early post-operative period, an enteric discharge was noticed, mandating surgical reexploration; a previously unnoticed bowel perforation, in the mesenteric border where the @entity1410 was identified, justified an additional enterectomy, after what the @entity1 recovery progressed uneventfully. DISCUSSION: In this case, a sudden increase in abdominal pressure could explain that missed rupture of the mesenteric border of the jejunum, also causing the mesenteric @entity1410 , or, in spite of that, a state of low perfusion could have lead to total wall @entity63 of an already irrigation compromised segment. Only noted after surgical exploration, despite prior evaluation with a computed tomography. Small bowell and @entity130 are potentially missed due to decreased exploratory laparotomies for blunt @entity1661 . CONCLUSION: Although uncommon, small bowel and @entity130 are associated with high morbidity and mortality. High clinical suspicion is essential for an early diagnosis.

title: Small bowell perforation and @entity130 after an unusual blunt XXXX -Case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal trauma']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['mesenteric injuries']

answer: @entity1661 :: (MESH:D000008,Disease) :: ['abdominal trauma']


abstract: INTRODUCTION: In blunt @entity1661 , lesions of the small bowell and mesentery are often underdiagnosed; although unusual, they represent the third most injured organ, with increasing morbidity and mortality. PRESENTATION OF CASE: The authors present the case of a 68 years old male, admitted to the emergency department after being hit by a bale of straw, weighing around 300kg, in the abdomen. After successful ressuscitation, a CT scan was performed, suggesting hemoperitoneum because of vascular lesion of the right colon @entity548 . An exploratory laparotomy was performed, confirming the presence of blood in the abdominal cavity and identifying jejunal perforation, an apparently innocent @entity1410 of the small bowel mesentery (beside the bowel wall) distally to the first lesion and a laceration of the sigmoid serosa; a segmental jejunal resection and suture of the colon serosa were performed. In the early post-operative period, an enteric discharge was noticed, mandating surgical reexploration; a previously unnoticed bowel perforation, in the mesenteric border where the @entity1410 was identified, justified an additional enterectomy, after what the @entity1 recovery progressed uneventfully. DISCUSSION: In this case, a sudden increase in abdominal pressure could explain that missed rupture of the mesenteric border of the jejunum, also causing the mesenteric @entity1410 , or, in spite of that, a state of low perfusion could have lead to total wall @entity63 of an already irrigation compromised segment. Only noted after surgical exploration, despite prior evaluation with a computed tomography. Small bowell and @entity130 are potentially missed due to decreased exploratory laparotomies for blunt @entity1661 . CONCLUSION: Although uncommon, small bowel and @entity130 are associated with high morbidity and mortality. High clinical suspicion is essential for an early diagnosis.

title: Small bowell perforation and XXXX after an unusual blunt @entity1661 -Case report.

answer: @entity130 :: (MESH:D014947,Disease) :: ['mesentery injury']


abstract: @entity712 ( @entity712 ) is characterized by @entity296 . A total of 146 @entity1 with @entity712 , were recruited. @entity712 severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). @entity235 modeling of @entity712 was induced by aortic banding. Hemodynamic and echocardiographic data were obtained before and after pressure loading and myocardial @entity43636 was determined. Mechanical stretch of cultured cardiomyocytes served as the cellular model of @entity712 . @entity1 with severe @entity712 had significantly higher plasma @entity43636 levels. Significant correlation between plasma @entity43636 and E/Em in advanced @entity712 @entity1 was noted. After 2 weeks of pressure overload in @entity235 models, the protein expression of @entity43636 from LV myocardial tissue was significantly increased (p   <   0.01) compared with controls. @entity43636 expression paralleled the severity of LV @entity67 by evaluation of CMRI (r   =   -0.58, p   =   0.003) and tissue @entity82 (r   =   0.59, p   =   0.002). After adjusting for confounders for @entity67 , @entity43636 levels were still associated with diastolic parameters both in @entity1 (p   <   0.001) and @entity235 model (p   =   0.041). Mechanical stretch increased @entity43636 secretion in cultured cardiomyocytes. Both plasma and myocardial @entity43636 levels correlated with severity of @entity299 .

title: XXXX level and the severity of @entity299 using cellular and animal models and clinical indices.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'humans', 'patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial interstitial fibrosis']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure with preserved ejection fraction', 'HFPEF']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac diastolic dysfunction']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction']

answer: @entity43636 :: (404021(Tax:9615),Gene) :: ['Galectin-3']


abstract: @entity712 ( @entity712 ) is characterized by @entity296 . A total of 146 @entity1 with @entity712 , were recruited. @entity712 severity was determined using Doppler imaging (E/Em) and also cardiac magnetic resonance imaging (CMRI). @entity235 modeling of @entity712 was induced by aortic banding. Hemodynamic and echocardiographic data were obtained before and after pressure loading and myocardial @entity43636 was determined. Mechanical stretch of cultured cardiomyocytes served as the cellular model of @entity712 . @entity1 with severe @entity712 had significantly higher plasma @entity43636 levels. Significant correlation between plasma @entity43636 and E/Em in advanced @entity712 @entity1 was noted. After 2 weeks of pressure overload in @entity235 models, the protein expression of @entity43636 from LV myocardial tissue was significantly increased (p   <   0.01) compared with controls. @entity43636 expression paralleled the severity of LV @entity67 by evaluation of CMRI (r   =   -0.58, p   =   0.003) and tissue @entity82 (r   =   0.59, p   =   0.002). After adjusting for confounders for @entity67 , @entity43636 levels were still associated with diastolic parameters both in @entity1 (p   <   0.001) and @entity235 model (p   =   0.041). Mechanical stretch increased @entity43636 secretion in cultured cardiomyocytes. Both plasma and myocardial @entity43636 levels correlated with severity of @entity299 .

title: @entity43636 level and the severity of XXXX using cellular and animal models and clinical indices.

answer: @entity299 :: (MESH:D006331,Disease) :: ['cardiac diastolic dysfunction']


abstract: PURPOSE: To report long-term follow-up of zonulo-hyaloido-vitrectomy (ZHV) via anterior approach for pseudophakic @entity726 refractory to medical treatment. DESIGN: Noncomparative case-series. MATERIALS AND METHODS: Medical records of 9 @entity1 who sought treatment for @entity7462 misdirection refractory to medical treatment were reviewed. All @entity1 underwent anterior vitrectomy, hyaloido-zonulectomy, and peripheral iridectomy (PI) via an anterior approach. Main outcome measures were preoperative and postoperative visual acuity, intraocular pressure, medications, slit-lamp examination, and fundus    ndings. RESULTS: 10 eyes of 9 @entity1 (7 female, 2 male) who underwent ZHV for refractory pseudophakic @entity726 between 2003 and 2010 were included in this case-series. The mean age of @entity1 was 77.4    9.0 years, mean follow-up duration 50.2    27.2 months. Recurrence of @entity726 was noted in 40% (four cases) after a successful ZHV on long-term follow-up. CONCLUSIONS: An anterior segment surgeon can treat @entity726 refractory to medical treatment successfully by vitrectomy, hyaloido-zonulectomy, and PI. This can be done via an anterior approach and @entity1 require long follow-up to rule out a relapse despite a successful outcome in the short term.

title: Long-term follow-up of zonulo-hyaloido-vitrectomy for pseudophakic XXXX .

entities_list: @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['malignant glaucoma']

answer: @entity726 :: (MESH:D005901,Disease) :: ['malignant glaucoma']


abstract: OBJECTIVE: To determine the safety, clinical outcome, and @entity174 rate of femoropopliteal interventions using 4F stents. METHODS: Between January 2010 and December 2011, 112 symptomatic @entity1 were treated by stent implantation. Ten @entity1 were lost to follow up; therefore, 102 @entity1 (62 @entity1 ; mean age 66.4      10.1  years) were retrospectively analyzed. The indication for femoropopliteal revascularization was severe @entity613 (Rutherford-Becker score  =  3) in 63 (62%) @entity1 and chronic @entity63 (Rutherford-Becker score  =  4-6) in 39 (38%). Follow up included palpation of peripheral pulses and measurement of ankle brachial index. In @entity1 with suspected in-stent restenosis duplex ultrasonography was performed. In 2013, @entity1 were asked to return for a fluoroscopic examination of the stents. RESULTS: 114 lesions (Trans-Atlantic InterSociety Consensus-C and D, n  =  45) were treated with 119 stents (Astron Pulsar, n  =  42; Pulsar-18, n  =  77). Lesions were long (>= 100  mm) in 49 cases and heavily calcified in 35. Stents were long (>= 120  mm) in 46 cases. Ten stents were partially overlapped. The technical and clinical success rates were 100%. Two puncture related complications were noted, neither of which required surgical repair. Eleven @entity1 died ( @entity583 , n  =  4; @entity64 , n  =  2; @entity5 , n  =  5) and nine @entity1 underwent major amputation (above knee, n  =  4). The primary patency rate was 83% at 6 months and 80% at 12 months. The primary assisted patency rate was 97% at 6 months and 94% at 12 months. The secondary patency rate was 86% at 6 months and 85% at 12 months. The prevalence of @entity174 was 26% (type III and IV, 10%) after an average follow up of 25 months. CONCLUSION: Femoropopliteal stenting using a 4F compatible delivery system can be accomplished with a low complication rate, acceptable @entity174 rate, and with similar 12 month patency and revascularization rates as their 6F counterparts.

title: Safety, Clinical Outcome, and XXXX Rate of Femoropopliteal Stenting Using a 4F Compatible Delivery System.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['critical limb ischemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['claudication']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Fracture']


abstract: BACKGROUND: The solid variant of @entity3557 (SVPTC) comprises approximately 3% of @entity259 , and there are conflicting reports about its behavior in the literature. The cytology of SVPTC is limited to 3 single case reports, a review article, and a monograph. We present the first cytologic study of SVPTC. METHODS: Fine-needle aspiration smears obtained with ultrasound guidance from 13 @entity1 with histologically pure SVPTC were reviewed, and the cytologic features recorded. Ultrasound images were retrieved from radiology and were correlated with low-power histology images. Intratumor vascularity on Doppler imaging was correlated with cellularity in cytology samples. RESULTS: Three cytomorphologic patterns of SVPTC were identified: cohesive, syncytial-type tissue fragments; microfollicles/trabeculae; and dyshesive single cells. @entity5953 SVPTCs in the first group were encapsulated without invasion. Two of 6 SVPTCs in the second group had a single lymph node @entity3 ; 4 were encapsulated, and 2 had pushing borders. Ultrasound images in the first and second SVPTC groups were similar, with the majority revealing a well defined, solid nodule with minimal intranodular vascularity. All 4 SVPTCs in the third group had infiltrative borders; and, with the exception of one 0.8-cm @entity5 , all had multiple lymph node @entity3 . Ultrasound in the third group revealed irregular borders. @entity8958 / @entity2750 and @entity8958 / @entity23275 mutations were found in 2 cases of the third group. CONCLUSIONS: SVPTCs are heterogeneous @entity5 . The cohesive, syncytial tissue-fragment pattern can be recognized as SVPTC in smears and is associated with encapsulation and indolent behavior. The microfollicular/trabecular pattern is indistinguishable from that of the follicular variant of @entity3557 and has intermediate behavior. The dyshesive single-cell pattern correlates with infiltrative @entity5 growth and may not be unique to SVPTC. @entity5 ( @entity5 Cytopathol) 2015.    2015 American @entity5 Society.

title: Fine-needle aspiration cytology of the solid variant of XXXX : A study of 13 cases with clinical, histologic, and ultrasound correlations.

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Cancer', 'tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancers']

answer: @entity3557 :: (MESH:C536915,Disease) :: ['papillary thyroid carcinoma']


abstract: UNASSIGNED: Background: Some cases of @entity5658 tend to be diagnosed as @entity483 ( @entity483 ) based on elevated levels of immunoglobulin E (IgE) and thymus and activation-regulated chemokine ( @entity14420 ). However, there are few studies that describe the detailed characteristics of @entity483 . Objective: We examined the association of @entity5658 with @entity483 . Methods: In this retrospective observational study, 68 @entity1 over 65 years of age who presented with @entity5658 at Osaka University Hospital were enrolled. @entity1 data were collected through medical records and descriptive statistics. Results: 47% of the @entity1 were classified as having idiopathic @entity5658 and 53% as having secondary @entity5658 . In both idiopathic and secondary @entity5658 patients, serum IgE and @entity14420 levels were elevated. 84% of idiopathic @entity5658 @entity1 fulfilled the Japanese Dermatological Associations criteria for @entity483 ; however, only 4 @entity1 were finally definitely diagnosed with @entity483 . Conclusion: Many @entity5658 @entity1 showed @entity483 -like symptoms due to T helper 2 polarization.    2015 S. Karger AG, Basel.

title: T Helper 2 Polarization in Senile Erythroderma with Elevated Levels of XXXX and IgE.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity483 :: ('MESH:D003876', 'Disease') :: ['senile erythroderma and senile AD', 'senile AD', 'senile atopic dermatitis', 'AD']

entities_list: @entity5658 :: ('MESH:D003873', 'Disease') :: ['erythroderma', 'senile erythroderma']

answer: @entity14420 :: (6361,Gene) :: ['TARC']


abstract: BACKGROUND AND PURPOSE: @entity1884 is an @entity74 that presents in 10%-20% of @entity1 with various @entity2457 . We aimed to report the radiologic features (phenotype) and the genotype-phenotype correlations of @entity2457 in @entity1884 . MATERIALS AND METHODS: Demographic, clinical, genotypic, and imaging information of 75 @entity1 with @entity1884 with @entity2758 enrolled in the @entity2457 Consortium from 2010 to 2012 were reviewed. RESULTS: Nonshunting, small, superficially located conglomerates of enhancing vessels without enlarged feeding arteries or draining veins called " @entity1462 " were the most commonly observed lesion (46 of 75 @entity1 ; 61%), followed by shunting "nidus-type" brain AVMs that were typically located superficially with a low Spetzler-Martin Grade and a small size (32 of 75 @entity1 ; 43%). Direct high-flow fistulous arteriovenous shunts were present in 9 @entity1 (12%). Other types of @entity1462 ( @entity600 ) were present in 1 @entity1 each. @entity1462 was seen in 33 cases (44%). No statistically significant correlation was observed between @entity1884 gene mutation and lesion type or lesion multiplicity. CONCLUSIONS: Depending on their imaging features, @entity2457 in @entity1884 can be subdivided into brain AVF, nidus-type AVM, and @entity1462 , with the latter being the most common phenotype in @entity1884 . No genotype-phenotype correlation was observed among @entity1 with this condition.

title: Neurovascular manifestations in XXXX : imaging features and genotype-phenotype correlations.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2758 :: ('MESH:D001165', 'Disease') :: ['brain arteriovenous malformations']

entities_list: @entity2457 :: ('MESH:D020785', 'Disease') :: ['brain vascular malformations', 'Brain Vascular Malformation']

entities_list: @entity1884 :: ('MESH:D013683', 'Disease') :: ['hereditary hemorrhagic telangiectasia', 'Hereditary hemorrhagic telangiectasia']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['dural AVF and developmental venous anomalies']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal dominant disease']

entities_list: @entity1462 :: ('MESH:D054079', 'Disease') :: ['capillary vascular malformations', 'vascular malformations', 'Multiplicity of vascular malformations']

answer: @entity1884 :: (MESH:D013683,Disease) :: ['hereditary hemorrhagic telangiectasia']


abstract: UNASSIGNED: Background: This study analyzed the @entity1 survival outcomes following the resection of @entity157 ( @entity157 ) metachronous adrenal metastasis (MAM) in @entity1 who had undergone liver resection or liver transplantation (LT). Methods: Clinical results were analyzed retrospectively in 26 @entity1 with MAM- @entity157 who underwent adrenalectomy. Results: The mean interval between initial surgery and adrenalectomy was significantly shorter in the resection group than in the LT group (18.3    14.4 vs. 42.6    13.8 months, p < 0.001). Of 19 resected @entity1 , four had adrenal metastases on the right side, 12 on the left side and three bilaterally, with a mean @entity5 diameter of 3.6    1.5 cm. Ten of these @entity1 underwent open surgery and nine underwent laparoscopic surgery; all @entity1 experienced @entity4557 within 18 months and 20.3% survived 5 years after adrenalectomy. Of 7 @entity1 who underwent LT, four had adrenal metastases on the right side and three on the left side, with a mean @entity5 diameter of 3.4    1.8 cm. Six of these @entity1 underwent open surgery and one underwent laparoscopic surgery. Five-year recurrence and @entity1 survival rates after adrenalectomy were 28.6 and 85.7%, respectively. Conclusions: Adrenalectomy is indicated in @entity1 with isolated MAM- @entity157 . Comparisons with other locoregional treatment modalities and multicenter studies with additional @entity1 are needed to validate the role of adrenalectomy.    2015 S. Karger AG, Basel.

title: Resection of Metachronous Adrenal Metastasis after Liver Resection and Transplantation for XXXX .

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity4557 :: ('MESH:D012008', 'Disease') :: ['recurrences']

answer: @entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']


abstract: Seventy-three @entity1 were operated on for confirmed @entity2742 . Identification of all glands was done by 1/3 biopsies for histopathologic examination on frozen section during the operation. In cases of @entity652 only, the @entity652 was removed except for the biopsies. In cases of @entity1373 , subtotal resection was made, leaving between a half-gland and a whole gland. The frequency of complications was analysed. Temporary @entity3747 occurred in a similar frequency in both @entity652 and @entity1373 groups. Permanent @entity3747 was present in only one @entity1 . At follow-up 3-5 years after operation, 98.6% of the @entity1 were normocalcemic. Ionized and total serum @entity460 were normalized 3 months after operation and remained so for the rest of the follow-up period. Serum @entity1391 , serum @entity1760 and serum @entity6685 also remained normal. Thus identification of parathyroid glands with biopsies or @entity512 in cases with @entity1373 did not increase the risk of @entity260 .

title: Complications to XXXX .

entities_list: @entity3747 :: ('MESH:D006996', 'Disease') :: ['hypocalcemia']

entities_list: @entity6685 :: ('MESH:D010281', 'Chemical') :: ['parathormone']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['hyperplasia']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity512 :: ('MESH:C567308', 'Disease') :: ['subtotal parathyroidectomy']

entities_list: @entity2742 :: ('MESH:D006961', 'Disease') :: ['hyperparathyroidism']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity512 :: (MESH:C567308,Disease) :: ['subtotal parathyroidectomy']


abstract: OBJECTIVE: To explore the therapeutic efficacy of allo-geneic hematopoietic stem cell transplantation (allo-HSCT) for @entity1860 ( @entity1860 ) @entity1 with @entity28837 mutation. METHODS: Retrospective analyses were conducted for 4 @entity1 with @entity28837 mutation of @entity1860 undergoing allo-HSCT from June 2012 to January 2014, including 2 cases in acceleration phase and 2 in chronic phase. There were 2 males and 2 females with ages from 26 to 45 years. Two @entity1 received HLA-matched sibling allo-geneic peripheral blood stem cell transplantation (allo-PBSCT) while another 2 unrelated cord blood stem cell transplantation (UCBT). No @entity381 was found before transplantation. One case had @entity28835 mutation. All of them were treated with @entity2213 before transplantation. And the time from medication to @entity28837 mutation was 20-35 months. All of them were conditioned with myeloablative regimen and received a combination of @entity205 ( @entity870 ) and @entity618 ( @entity2098 ) for preventing @entity2132 ( @entity2132 ). RESULTS: Myeloid implantation was achieved in all of them. The time of absolute neutrophil count (ANC) >=  0.5*10(9)/L were 10-28 days. One @entity1 whose platelet was not implanted died from severe @entity358 at Day 88 post-transplantation. For 3 @entity1 , platelet >=  20*10(9)/L were 15-33 days. But the marrow short tandem repeat (STR)-PCR was 100% donor type at the time of 30 days post-transplantation in all @entity1 . One case of UCBT developed pre-implantation immune response syndrome (PES) and one acute @entity2132 of gradeI at Day 12 after allo-PBSCT. However both were controlled after treatment with @entity1667 . @entity676 /3 evaluatable @entity1 developed chronic @entity2132 . @entity1864 transcript was detected by qualitative PCR after transplantation. And all @entity1864 fusion genes turned negative after 30 days of transplantation. Up to the follow-up endpoint, there was no relapse except for one mortality. And the time of disease-free survival was 133, 248 and 704 days respectively. CONCLUSIONS: Allo-HSCT is currently the optimal treatment for @entity28837 mutation of @entity1860 . And umbilical cord blood is an ideal donor for those @entity1 without HLA-matched sibling donor.

title: [Allo-geneic hematopoietic stem cell transplantation in treatment with @entity28837 mutation of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine A']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['GVHD', 'graft-versus-host disease']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity618 :: ('MESH:C063008', 'Chemical') :: ['mycophenolate mofetil']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary infection']

entities_list: @entity1860 :: ('MESH:D015464', 'Disease') :: ['CML', 'chronic myelogenous leukemia']

entities_list: @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib']

answer: @entity1860 :: (MESH:D015464,Disease) :: ['chronic myelogenous leukemia']


abstract: OBJECTIVE: To explore the therapeutic efficacy of allo-geneic hematopoietic stem cell transplantation (allo-HSCT) for @entity1860 ( @entity1860 ) @entity1 with @entity28837 mutation. METHODS: Retrospective analyses were conducted for 4 @entity1 with @entity28837 mutation of @entity1860 undergoing allo-HSCT from June 2012 to January 2014, including 2 cases in acceleration phase and 2 in chronic phase. There were 2 males and 2 females with ages from 26 to 45 years. Two @entity1 received HLA-matched sibling allo-geneic peripheral blood stem cell transplantation (allo-PBSCT) while another 2 unrelated cord blood stem cell transplantation (UCBT). No @entity381 was found before transplantation. One case had @entity28835 mutation. All of them were treated with @entity2213 before transplantation. And the time from medication to @entity28837 mutation was 20-35 months. All of them were conditioned with myeloablative regimen and received a combination of @entity205 ( @entity870 ) and @entity618 ( @entity2098 ) for preventing @entity2132 ( @entity2132 ). RESULTS: Myeloid implantation was achieved in all of them. The time of absolute neutrophil count (ANC) >=  0.5*10(9)/L were 10-28 days. One @entity1 whose platelet was not implanted died from severe @entity358 at Day 88 post-transplantation. For 3 @entity1 , platelet >=  20*10(9)/L were 15-33 days. But the marrow short tandem repeat (STR)-PCR was 100% donor type at the time of 30 days post-transplantation in all @entity1 . One case of UCBT developed pre-implantation immune response syndrome (PES) and one acute @entity2132 of gradeI at Day 12 after allo-PBSCT. However both were controlled after treatment with @entity1667 . @entity676 /3 evaluatable @entity1 developed chronic @entity2132 . @entity1864 transcript was detected by qualitative PCR after transplantation. And all @entity1864 fusion genes turned negative after 30 days of transplantation. Up to the follow-up endpoint, there was no relapse except for one mortality. And the time of disease-free survival was 133, 248 and 704 days respectively. CONCLUSIONS: Allo-HSCT is currently the optimal treatment for @entity28837 mutation of @entity1860 . And umbilical cord blood is an ideal donor for those @entity1 without HLA-matched sibling donor.

title: [Allo-geneic hematopoietic stem cell transplantation in treatment with XXXX mutation of @entity1860 ].

answer: @entity28837 :: (p|SUB|T|315|I,ProteinMutation) :: ['T315I']


abstract: BACKGROUND: Little is known about the degree of articular cartilage degeneration after subtotal/total lateral meniscectomy in @entity1 who later undergo isolated @entity8 ( @entity8 ). It has not yet been studied whether arthritic changes as shown on radiographs were lower during the posttransplantation period than during the meniscus-deficient period. HYPOTHESIS: Articular cartilage will significantly degenerate during the meniscus-deficient period, but the progression in radiographic @entity4040 is reduced after @entity8 . STUDY DESIGN: Case series; Level of evidence, 4. METHODS: This study retrospectively reviewed 49 @entity1 who underwent subtotal/total lateral meniscectomy before isolated @entity8 performed over 1 year later by the same surgeon. International Cartilage Repair Society (ICRS) grades of the femorotibial joint at the time of subtotal/total meniscectomy and at @entity8 were compared. Radiographic evaluation was performed at the time of initial meniscectomy, @entity8 , and the latest follow-up in 38 @entity1 (after 11 @entity1 whose radiographs showed incomplete ossification at the time of meniscectomy were excluded). @entity4040 , based on Kellgren-Lawrence (K-L) grades, was determined on standing anteroposterior views. Joint space width (JSW) was measured on weightbearing flexion posteroanterior views. RESULTS: Over a mean meniscus-deficient period of 4.5 years (range, 1-13 years), articular cartilage significantly degenerated on the femoral and tibial sides (P < .001). Grade >= 3 degeneration on the lateral tibial plateau was observed in 13 @entity1 (27%) at the time of initial meniscectomy; this incidence doubled to 28 @entity1 (57%) by the time of @entity8 . The K-L grades worsened (P < .001) and JSWs narrowed significantly (-0.65    1.09 mm; P = .001) during the mean meniscus-deficient period of 3.1 years. At radiographic assessment, however, the K-L grades (P = .097) and JSWs (4.06    1.19 vs 3.92    1.21 mm; mean difference, -0.14    0.68 mm; P = .213) did not significantly change during the mean posttransplantation period of 3.8 years. The changes in ICRS grade and JSW during the meniscus-deficient period were not associated with age, body mass index, mechanical axis deviation, or Tegner activity level (P > .05 for all relationships). CONCLUSION: @entity1 who underwent isolated @entity8 showed substantial articular cartilage degeneration at the time of initial subtotal/total lateral meniscectomy, and this degeneration progressed thereafter. Further progression of radiographic @entity4040 was delayed after @entity8 .

title: Articular Cartilage Degenerates After Subtotal/Total Lateral Meniscectomy but Radiographic XXXX Progression Is Reduced After Meniscal Transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['lateral meniscal allograft transplantation', 'LMAT']

entities_list: @entity4040 :: ('MESH:C537208', 'Disease') :: ['arthrosis', 'Arthrosis']

answer: @entity4040 :: (MESH:C537208,Disease) :: ['Arthrosis']


abstract: UNASSIGNED: Background. Recently, combined intra-articular @entity927 (IA- @entity928 ) injection with clamping drain method showed efficacy for @entity190 and transfusion reduction in total knee replacement (TKR). However, until now, none of previous studies revealed the effect of this technique on pharmacokinetics, coagulation, and fibrinolysis. Materials and Methods. An experimental study was conducted, during 2011-2012, in 30 @entity1 undergoing unilateral TKR. @entity1 received IA- @entity928 application and then were allocated into six groups regarding clamping drain duration (2-, 4-, 6-, 8-, 10-, and 12-hours). Blood and drainage fluid were collected to measure @entity927 ( @entity928 ) level and @entity3459 and fibrinolytic markers. @entity260 was followed for one year. Results. There was no significant difference of serum @entity928 level at 2 hour and 24 hour among groups (p < 0.05). Serum @entity928 level at time of clamp release was significantly different among groups with the highest level at 2 hour (p < 0.0001). There was no significant difference of @entity928 level in drainage fluid, postoperative @entity190 , blood transfusion, and @entity260 (p < 0.05).      Conclusions. Low-dose IA- @entity928 application in TKR with prolonged clamping drain method is a safe and effective blood conservative technique with only minimal systemic absorption and without significant increase in systemic absorption over time.

title: An In Vivo Study of Low-Dose Intra-Articular XXXX Application with Prolonged Clamping Drain Method in Total Knee Replacement: Clinical Efficacy and Safety.

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative complication', 'postoperative complications']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['related coagulation']

entities_list: @entity927 :: ('MESH:D014148', 'Chemical') :: ['tranexamic acid']

answer: @entity927 :: (MESH:D014148,Chemical) :: ['Tranexamic Acid']


abstract: UNASSIGNED: Aims. @entity1 action potentials in the @entity1789 have been characterized by delayed or even complete loss of dome formation, especially in the right @entity67 . Such a repolarization pattern is believed to trigger phase-2 reentry (P2R); however, little is known about the conditions necessary for its initiation. This study aims to determine the specific mechanisms that facilitate P2R induction in Brugada-affected cardiac tissue in @entity1 . Methods. Ionic models for @entity1789 in @entity1 epicardial cells were developed and used to study the induction of P2R in cables, sheets, and a three-dimensional model of the right ventricular free wall. Results. In one-dimensional cables, P2R can be induced by adjoining lost-dome and delayed-dome regions, as mediated by tissue excitability and transmembrane voltage profiles, and reduced coupling facilitates its induction. In two and three dimensions, sustained reentry can arise when three regions (delayed-dome, lost-dome, and normal epicardium) are present. Conclusions. Not only does P2R induction by @entity1789 require regions of action potential with delayed-dome and lost-dome, but in order to generate a sustained reentry from a triggered waveback multiple factors are necessary, including heterogeneity in action potential distribution, tissue coupling, direction of stimulation, the shape of the late plateau, the duration of lost-dome action potentials, and recovery of tissue excitability, which is predominantly modulated by tissue coupling.

title: Basis for the Induction of Tissue-Level Phase-2 Reentry as a Repolarization Disorder in the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human', 'Human']

entities_list: @entity1789 :: ('MESH:D053840', 'Disease') :: ['Brugada syndrome']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['ventricular epicardial layers']

answer: @entity1789 :: (MESH:D053840,Disease) :: ['Brugada Syndrome']


abstract: UNASSIGNED: We developed a new @entity4279 coating technology for @entity702 hip implants and performed a clinical trial to assess its usefulness in suppressing @entity86 . Results indicate that @entity1496 -supported @entity702 has favorable antibacterial activity, biocompatibility, and no @entity137 . Thirty joints in 28 @entity1 were treated using @entity1496 -supported implants. Fourteen joints were revision @entity572 ( @entity572 ) after @entity281 , 13 were primary @entity572 for immunosuppressive conditions or @entity625 , and 3 were conversions from hemiarthroplasty to @entity572 for immunosuppressive conditions. Two examinations were conducted sequentially until final follow-up: white blood cell (WBC) and @entity1851 ( @entity1851 ) were measured pre- and postoperatively and thyroid hormone levels in the blood were examined. The mean follow-up period was 33 months (14-78). There were no signs of @entity281 in any @entity1 at the last follow-up. WBC and @entity1851 levels returned to normal within several weeks. No abnormalities of thyroid gland function were detected. Loosening of the implants did not occur in any @entity1 . Excellent bone ingrowth and ongrowth were found around prostheses. No @entity137 or adverse effects were detected. These results suggest that @entity1496 -supported @entity572 implants can be highly effective in preventing and treating @entity86 .

title: XXXX -Supported Hip Implants: Short Term Clinical Results.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['pyogenic arthritis']

entities_list: @entity4279 :: ('MESH:D011206', 'Chemical') :: ['povidone iodine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['periprosthetic infection', 'infection']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative infections', 'postoperative infection']

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity1496 :: (MESH:D007455,Chemical) :: ['Iodine']


abstract: STUDY DESIGN: Retrospective chart review. OBJECTIVE: To determine the efficacy of adjuvant cryotherapy in the treatment of early @entity5 and @entity16850 . SUMMARY OF BACKGROUND DATA: The use of cryotherapy in conjunction with traditional modalities has recently been proposed to improve voice outcomes in @entity1 with early @entity5 as compared to pretreatment conditions. This study investigates its utility in improving oncological outcomes and decreasing recurrences of @entity16850 . METHODS: @entity1 with either early @entity5 or @entity16850 that received cryotherapy as part of their surgical regimen were investigated. All @entity1 were seen at a large tertiary care center within a 10-year window. Demographic data were collected and all postoperative notes were reviewed. Recurrences of the @entity5 were noted, as was the duration of time between successive @entity1185 operations. RESULTS: The charts of 54 @entity5 and 29 @entity1185 @entity1 that received cryotherapy were reviewed. One @entity1 from the @entity1185 cohort was excluded from statistical analysis due to lack of follow-up. Overall, 16 (30%) of the @entity5 @entity1 experienced a malignant recurrence. The overall 5-year survival of these @entity1 was 98% and the 5-year disease-free survival was 74%. The use of adjuvant cryotherapy in the treatment of @entity16850 extended the duration of time between surgeries by an average of 79 days (P = .23). CONCLUSION: The use of adjuvant cryotherapy in the treatment of early @entity5 does not improve the rate of @entity189 recurrences. Additionally, cryotherapy does not result in a statistically significant increase in the duration of disease-free period for @entity16850 @entity1 , although the observed increase may be clinically important.

title: The Use of Cryotherapy for XXXX and Early Laryngeal Cancers: Long-term Results.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity16850 :: ('MESH:C537876', 'Disease') :: ['laryngeal papillomatosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['laryngeal cancer', 'glottic cancer']

entities_list: @entity1185 :: ('MESH:D010212', 'Disease') :: ['papillomatosis']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

answer: @entity1185 :: (MESH:D010212,Disease) :: ['Papilloma']


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity683 .   Individual- @entity1 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity683 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity1 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity1576 in 48.6%, @entity55 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity689 inhibitors ( @entity11925 ) (73.8% received @entity684 and 1.4% received @entity23217 / @entity685 ; 44.5% of @entity1 received @entity11925    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity288 . There were fewer @entity204 among @entity11925 -treated @entity1 (5.3% versus 7.6%; p=0.032). @entity11925 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity1 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity11925 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity288 increased superinfection (9.7% versus 2.7%) and @entity204 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity11925 treatment was associated with shorter length of stay in a subanalysis. @entity11925 treatment may improve survival of hospitalised @entity683 @entity1 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity288 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: XXXX inhibitors, superinfection and @entity288 affect survival of @entity683 @entity1 .

entities_list: @entity689 :: ('4758', 'Gene') :: ['neuraminidase']

entities_list: @entity684 :: ('MESH:D053139', 'Chemical') :: ['oseltamivir']

entities_list: @entity685 :: ('MESH:D053243', 'Chemical') :: ['zanamivir']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity683 :: ('MESH:D007251', 'Disease') :: ['influenza']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory-failure']

entities_list: @entity23217 :: ('MESH:C414210', 'Chemical') :: ['peramivir']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids', 'Corticosteroids']

answer: @entity689 :: (4758,Gene) :: ['Neuraminidase']


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity683 .   Individual- @entity1 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity683 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity1 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity1576 in 48.6%, @entity55 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity689 inhibitors ( @entity11925 ) (73.8% received @entity684 and 1.4% received @entity23217 / @entity685 ; 44.5% of @entity1 received @entity11925    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity288 . There were fewer @entity204 among @entity11925 -treated @entity1 (5.3% versus 7.6%; p=0.032). @entity11925 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity1 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity11925 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity288 increased superinfection (9.7% versus 2.7%) and @entity204 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity11925 treatment was associated with shorter length of stay in a subanalysis. @entity11925 treatment may improve survival of hospitalised @entity683 @entity1 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity288 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: @entity689 inhibitors, superinfection and @entity288 affect survival of XXXX @entity1 .

answer: @entity683 :: (MESH:D007251,Disease) :: ['influenza']


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity683 .   Individual- @entity1 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity683 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity1 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity1576 in 48.6%, @entity55 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity689 inhibitors ( @entity11925 ) (73.8% received @entity684 and 1.4% received @entity23217 / @entity685 ; 44.5% of @entity1 received @entity11925    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity288 . There were fewer @entity204 among @entity11925 -treated @entity1 (5.3% versus 7.6%; p=0.032). @entity11925 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity1 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity11925 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity288 increased superinfection (9.7% versus 2.7%) and @entity204 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity11925 treatment was associated with shorter length of stay in a subanalysis. @entity11925 treatment may improve survival of hospitalised @entity683 @entity1 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity288 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: @entity689 inhibitors, superinfection and XXXX affect survival of @entity683 @entity1 .

answer: @entity288 :: (MESH:D000305,Chemical) :: ['corticosteroids']


abstract: UNASSIGNED: We aimed to study factors influencing outcomes of adults hospitalised for seasonal and pandemic @entity683 .   Individual- @entity1 data from three Asian cohorts (Hong Kong, Singapore and Beijing; N=2649) were analysed. Adults hospitalised for laboratory-confirmed @entity683 (prospectively diagnosed) during 2008-2011 were studied. The primary outcome measure was 30-day survival. Multivariate Cox regression models (time-fixed and time-dependent) were used. @entity1 had high morbidity (respiratory/nonrespiratory complications in 68.4%, @entity1576 in 48.6%, @entity55 in 40.8% and bacterial superinfections in 10.8%) and mortality (5.9% at 30   days and 6.9% at 60   days). 75.2% received @entity689 inhibitors ( @entity11925 ) (73.8% received @entity684 and 1.4% received @entity23217 / @entity685 ; 44.5% of @entity1 received @entity11925    2   days and 65.5%    5   days after onset of illness); 23.1% received systemic @entity288 . There were fewer @entity204 among @entity11925 -treated @entity1 (5.3% versus 7.6%; p=0.032). @entity11925 treatment was independently associated with survival (adjusted hazard ratio (HR) 0.28, 95% CI 0.19-0.43), adjusted for treatment-propensity score and @entity1 characteristics. Superinfections increased (adjusted HR 2.18, 95% CI 1.52-3.11) and chronic statin use decreased (adjusted HR 0.44, 95% CI 0.23-0.84) death risks. Best survival was shown when treatment started within    2   days (adjusted HR 0.20, 95% CI 0.12-0.32), but there was benefit with treatment within 3-5   days (adjusted HR 0.35, 95% CI 0.21-0.58). Time-dependent analysis showed consistent results of @entity11925 treatment (adjusted HR 0.39, 95% CI 0.27-0.57). @entity288 increased superinfection (9.7% versus 2.7%) and @entity204 when controlled for indications (adjusted HR 1.73, 95% CI 1.14-2.62). Early @entity11925 treatment was associated with shorter length of stay in a subanalysis. @entity11925 treatment may improve survival of hospitalised @entity683 @entity1 ; benefit is greatest from, but not limited to, treatment started within 2   days of illness. Superinfections and @entity288 increase mortality. Antiviral and non-antiviral management strategies should be considered.

title: @entity689 inhibitors, superinfection and @entity288 affect survival of @entity683 XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Three groups of 4 @entity742 each were experimentally infected with an isolate of progressive @entity55 virus ( @entity2286 ) by intracerebral, intra-articular, or intrathoracic routes of inoculation. An additional control group was sham-inoculated by all 3 routes with identically prepared, noninfected inoculum. @entity742 were killed 12 to 42 days after inoculation. A mild generalized @entity3554 was found in 2 of the 4 @entity742 inoculated intracerebrally. A severe, @entity603 with massive infiltration of lymphocytes and plasma cells was found in the 4 @entity742 inoculated intraarticularly. Germinal center formation was found in the synovial membrane 42 days after inoculation. Appreciable differences in lung morphologic features were not observed among the 4 groups. The @entity2286 was isolated from virus-inoculated @entity742 from the choroid plexus, synovium, and lungs from inoculated and noninoculated sites. Nine of the 12 virus-inoculated lambs developed serum antibody to @entity2286 , and specific antibodies were found in the synovial fluid of virus-inoculated joints. Virus was not isolated, lesions were not found, and serum antibody was not demonstrated in sham-inoculated @entity742 .

title: Ovine progressive XXXX : experimental intrathoracic, intracerebral, and intra-articular infections.

entities_list: @entity603 :: ('MESH:D013585', 'Disease') :: ['proliferative synovitis']

entities_list: @entity3554 :: ('MESH:D008577', 'Disease') :: ['leptomeningitis']

answer: @entity55 :: (MESH:D011014,Disease) :: ['pneumonia']


abstract: UNASSIGNED: The interaction between cell surface glycans and extracellular matrix  (ECM) including galectins is known to be closely associated with @entity5 cell adhesion, invasion and @entity3 . We analyzed the roles of cell surface sialylation or glycosylation in galectin or ECM  -mediated cell adhesion and invasion of @entity1 @entity706 cells. @entity689 from Arthrobacter ureafaciens  (AU) treatment resulted in reduction of cell adhesion to @entity41786 in @entity1 @entity2108  (H  -ALCL) which was established in our laboratory. The knockdown of b  -galactoside a  -2,6  -sialyltrans-ferase  ( @entity15695 ) by siRNA showed inhibition of @entity15695 expression in the cytoplasm of H  -ALCL cells on immunohistochemical findings, and showed dramatic enhancement of cell adhesion to @entity41786 . On the other hand, a  -2,3  -specific @entity689 treatment resulted in moderate enhancement of cell adhesion to @entity41786 . We performed chemically artificial modification of cell surface O  -glycans by treatment of benzyl 2  -acetamido  -2  -deoxy  -a  -D  -galactopyranoside  (Bz  -a  -GalNAc) in H  -ALCL. Cell adhesion to @entity41786 was enhanced by treatment of Bz  -a  -GalNAc suggesting that inhibition of elongation of O  -glycans may enhance cell adhesion to @entity41786 in H  -ALCL cells. On the other hand inhibition of elongation of N  -glycosylation by tunicamycin  (TM) resulted in inhibition of @entity11297  (L  -PHA) lectin  -binding activity and inhibited cell adhesion to @entity41786 , laminin and fibronectin. @entity689 treatment enhanced cell adhesion to laminin, and knockdown of @entity15695 resulted in enhancement of cell adhesion to laminin, but not to fibronectin, collagen type  1  and  4. @entity41786 pre  -treatment dramatically enhanced cell adhesion to laminin and @entity689 treatment also enhanced cell adhesion to laminin in combination with @entity41786 . Rho inhibitor, C3  -transferase pre  -treatment resulted in inhibition of cell invasion to @entity41786 . Phosphatidylinositol  3  -phosphate kinase  (PI3K) inhibitor, wortmannin inhibits the cell invasive capacity to @entity41786 . @entity689 treatment induces growth inhibition of @entity706 cells by @entity41786 .

title: Sialylation by b  -galactoside a  -2,6  -sialyltransferase and N  -glycans regulate cell adhesion and invasion in @entity1 XXXX .

entities_list: @entity689 :: ('4758', 'Gene') :: ['Neuraminidase', 'neuraminidase']

entities_list: @entity11297 :: ('3885', 'Species') :: ['Phaseolus vulgaris  -L']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'malignant lymphoma']

entities_list: @entity2108 :: ('MESH:D017728', 'Disease') :: ['anaplastic large cell lymphoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity2108 :: (MESH:D017728,Disease) :: ['anaplastic large cell lymphoma']


abstract: UNASSIGNED: The interaction between cell surface glycans and extracellular matrix  (ECM) including galectins is known to be closely associated with @entity5 cell adhesion, invasion and @entity3 . We analyzed the roles of cell surface sialylation or glycosylation in galectin or ECM  -mediated cell adhesion and invasion of @entity1 @entity706 cells. @entity689 from Arthrobacter ureafaciens  (AU) treatment resulted in reduction of cell adhesion to @entity41786 in @entity1 @entity2108  (H  -ALCL) which was established in our laboratory. The knockdown of b  -galactoside a  -2,6  -sialyltrans-ferase  ( @entity15695 ) by siRNA showed inhibition of @entity15695 expression in the cytoplasm of H  -ALCL cells on immunohistochemical findings, and showed dramatic enhancement of cell adhesion to @entity41786 . On the other hand, a  -2,3  -specific @entity689 treatment resulted in moderate enhancement of cell adhesion to @entity41786 . We performed chemically artificial modification of cell surface O  -glycans by treatment of benzyl 2  -acetamido  -2  -deoxy  -a  -D  -galactopyranoside  (Bz  -a  -GalNAc) in H  -ALCL. Cell adhesion to @entity41786 was enhanced by treatment of Bz  -a  -GalNAc suggesting that inhibition of elongation of O  -glycans may enhance cell adhesion to @entity41786 in H  -ALCL cells. On the other hand inhibition of elongation of N  -glycosylation by tunicamycin  (TM) resulted in inhibition of @entity11297  (L  -PHA) lectin  -binding activity and inhibited cell adhesion to @entity41786 , laminin and fibronectin. @entity689 treatment enhanced cell adhesion to laminin, and knockdown of @entity15695 resulted in enhancement of cell adhesion to laminin, but not to fibronectin, collagen type  1  and  4. @entity41786 pre  -treatment dramatically enhanced cell adhesion to laminin and @entity689 treatment also enhanced cell adhesion to laminin in combination with @entity41786 . Rho inhibitor, C3  -transferase pre  -treatment resulted in inhibition of cell invasion to @entity41786 . Phosphatidylinositol  3  -phosphate kinase  (PI3K) inhibitor, wortmannin inhibits the cell invasive capacity to @entity41786 . @entity689 treatment induces growth inhibition of @entity706 cells by @entity41786 .

title: Sialylation by b  -galactoside a  -2,6  -sialyltransferase and N  -glycans regulate cell adhesion and invasion in XXXX @entity2108 .

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: This is the second of three papers investigating the legislative history concerning infanticide. It compares the efforts of various states to protect the newborn @entity1 between 534 and 1532 CE. When the Roman Empire collapsed in the 5th century, the jurisdiction of infanticide was relegated to the church, which regarded carnal delicts a @entity26634 rather than a crime. The punishment - public penance of the mother for 7-15 years - was milder than that which the murder of an adult would incur. The Council of Florence decreed in 1439 that the souls of @entity1 who died without having been baptized descend to hell. This turned infanticide from a penitential @entity26634 to the most heinous of all crimes. The states passed laws that abominated infanticide even more than the murder of older @entity1 and punished @entity1 with ever more cruel forms of execution. Towards the @entity1 , however, who usually abandoned the @entity1 they had impregnated, the laws were lenient. Churches and society continued to vilify illegitimate birth, thus enhancing rather than preventing infanticide. The Habsburg-German legislation of 1532 ordained to torture any @entity1 who had concealed pregnancy and birth and claimed the @entity1 was stillborn. Legislation developed similarly in other countries, albeit at a different speed. French (1556) and British (1623) legislation reversed the burden of proof and demanded the death penalty for concealing pregnancy and birth when a dead @entity1 was found.

title: From XXXX to Crime: Laws on Infanticide in the Middle Ages.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'children', 'humans', 'woman', 'infant', 'men']

answer: @entity26634 :: (10278,Gene) :: ['Sin']


abstract: UNASSIGNED: @entity47460 @entity1737 is an @entity74 due to @entity47460 mutations. Anticholinesterase therapy is ineffective and may worsen the @entity425 in @entity1 with @entity47460 @entity1737 or few other forms of @entity8491 . We describe a 31-year-old @entity1 previously diagnosed with seronegative @entity1737 . Repetitive stimulation of the right spinal accessory nerve showed 51% decrement. Needle electromyography revealed @entity121 in clinically affected muscles. Muscle biopsy was normal. The @entity1 was referred to us for worsening @entity425 after taking @entity4836 . We searched for @entity47460 mutations and identified compound heterozygous mutations of a common @entity71411 mutation and a novel splice site mutation, @entity71412 . Discontinuation of @entity4836 improved @entity425 . He further regained strength with oral @entity3045 therapy and decrement was reduced to 25%. Worsening of symptoms with anticholinesterase therapy in @entity1 with "seronegative @entity1737 " should prompt clinicians to consider a possibility of @entity8491 to avoid unnecessary use of immunosuppressive therapy. @entity1 with @entity47460 @entity1737 respond well to oral @entity3045 treatment.

title: Anticholinesterase Therapy Worsening Head Drop and Limb Weakness Due to a Novel XXXX Mutation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'man']

entities_list: @entity71412 :: ('c|INDEL|772+2_+4|CCGGGCAGGCGGGCA', 'DNAMutation') :: ['c.772+2_+4delinsCCGGGCAGGCGGGCA']

entities_list: @entity3045 :: ('MESH:D000420', 'Chemical') :: ['albuterol']

entities_list: @entity4836 :: ('MESH:D011729', 'Chemical') :: ['pyridostigmine']

entities_list: @entity1737 :: ('MESH:D009157', 'Disease') :: ['myasthenia', 'myasthenia gravis']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['autosomal recessive congenital myasthenic syndrome']

entities_list: @entity8491 :: ('MESH:D020294', 'Disease') :: ['congenital myasthenic syndromes']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathic changes']

answer: @entity47460 :: (285489,Gene) :: ['DOK7']


abstract: OBJECTIVES: The evaluation of Barrett's glands buried underneath esophageal squamous epithelium becomes increasingly important to achieve curative treatments. However, clinically available endoscopies have critical limitations in depicting the subsurface structure, resulting in non-curative treatments. Optical coherence tomography (OCT) can acquire a high-resolution cross-sectional image, equivalent to an 'optical biopsy'. We aimed to assess the feasibility of the in vivo use of probe-type OCT imaging to evaluate @entity355 buried underneath esophageal squamous epithelium METHODS: We conducted a single-center prospective study with 14 consecutive @entity1 with @entity420 from 2008 to 2014. The enrolled @entity1 were examined by a probe-type OCT in vivo, followed by en bloc endoscopic submucosal dissection (ESD) with electric marking. Then, the one-to-one correlations between the OCT images of the buried mucosa and their histological assessment were examined. RESULTS: The overall accuracy, sensitivity, specificity, positive predictive value and negative predictive value of the buried mucosa in the OCT imaging were 85.7% (12/14), 77.8% (7/9), 100% (5/5), 100% (7/7) and 71.4% (5/7), respectively. However, OCT could not easily distinguish @entity3257 from @entity6349 . Additionally, the linear distance from the histological squamo-columnar junction in correct cases tended to be longer than that in incorrect cases (mm, median [range]: 2.0 [0.7-7.5] vs. 0.5 [0.5-0.5]). CONCLUSIONS: We demonstrated, for the first time, that pre-operative OCT imaging might be feasible for detecting the oral side extension of buried @entity355 to remove the entire area with malignant potential by ESD. This article is protected by copyright. All rights reserved.

title: Feasibility of optical coherence tomography for the evaluation of XXXX buried underneath esophageal squamous epithelium.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's mucosa"]

entities_list: @entity3257 :: ('MESH:C580335', 'Disease') :: ['non-dysplastic glands']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ["Barrett's adenocarcinoma"]

entities_list: @entity6349 :: ('MESH:D004416', 'Disease') :: ['dysplastic glands']

answer: @entity355 :: (MESH:D001471,Disease) :: ['Barrett's mucosa']


abstract: UNASSIGNED: Unilateral spatial neglect consists of the inability of a @entity1 to respond, orient, and attend to stimuli on the left side of a space following a right-hemisphere lesion. Many rehabilitation approaches have been proposed to reduce neglect. The aim of our study was to compare the effect of @entity227 ( @entity227 ) and prismatic adaptation (PA) on @entity1 with neglect following a right-hemisphere lesion. Twenty @entity1 with left neglect were enrolled in the study. Before and after training, a comprehensive neuropsychological assessment of visuospatial abilities, evaluating personal, peripersonal, and extrapersonal neglect, was performed. After assessment, @entity1 were alternately assigned to 1 of 2 groups, @entity227 or PA. Both trainings consisted of 20 sessions, 1 per day, 5 days a week for 4 weeks. The results showed that both treatments improved @entity1 neglect, especially in personal and peripersonal spaces. No difference between pretreatment and posttreatment was found in extrapersonal subscales. This finding could be due to the fact that there were no exercises requiring the use of objects within reach in either training. In conclusion, no difference between the 2 approaches was found, and both are useful rehabilitation techniques that appear to improve neglect.

title: Efficacy of XXXX and prism adaptation for neglect rehabilitation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual-scanning training', 'VST']

answer: @entity227 :: (MESH:D014786,Disease) :: ['visual-scanning training']


abstract: The prevalence of psychotropic and nonpsychotropic drug prescriptions in institutions and community residential facilities in 1978-79 was assessed. The data were gathered as an incidental part of a comprehensive national interview study of the characteristics of residential facilities and their residents. The study included 2271 retarded individuals in 236 residential facilities in the US. Facilities were selected through a 2-stage probability sample design in such a way that the probability of a facility's selection was proportionate to its size (number of residents) and so that the distribution of sample facilities across census regions and size classes was in close agreement with the distribution of facilities nationally. Interviews at 75 institutions and 161 private facilities were conducted between September 1978 and April 1979. Demographic information about individual residents, including date of birth, date of admission, previous type of residential placement, age, height, weight, diagnosed degree of retardation, and diagnosis of @entity302 , @entity2438 , or @entity1032 , was obtained from each resident's records. The staff @entity1 most familiar with each resident was then identified and interviewed about the resident. Care @entity1 were asked whether and for what purpose drugs were prescribed for each resident. 75.8% of institutionalized residents and 54.3% of community facility residents were reported to be receiving at least 1 type of regularly prescribed medication. Percentages reported for specific drugs should be considered minimums, because drug names were not always elicited if the drug's purpose was known. Drugs not named, but reported to be prescribed for a chronic health condition, @entity302 , a @entity146 problem, for sleeping, or for birth control, were listed with "other" within tentative categories. Multiple regression was used to examine the relationships among drug use and several resident and facility characteristics. The institutionalized and community-based samples were combined for these analyses. Drugs reported to be prescribed for chronic health problems most frequently were used by older, nonambulatory residents who had health problems. Use of antiepilepsy drugs was most closely associated with a history of @entity410 . Only 1.3% of community facility residents and 1.6% of institutionalized residents whose records did not document @entity302 were reported to be receiving antiepilepsy drugs. Psychotropic drugs most often were prescribed for residents with @entity146 or for those with a recorded mention of @entity1032 or @entity2438 . Older, heavier, and more severely retarded residents also were more likely to receive psychotropic drugs. Contraceptive drugs were predicted by age, sex, ability, and minority status. Younger and @entity1032 @entity1 were more likely to receive birth control methods, as were minorities.

title: A national study of prescribed drugs in institutions and community residential facilities for XXXX @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'person', 'persons']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness', 'less retarded']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'behavior problems']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

answer: @entity1032 :: (MESH:D008607,Disease) :: ['mentally retarded']


abstract: The prevalence of psychotropic and nonpsychotropic drug prescriptions in institutions and community residential facilities in 1978-79 was assessed. The data were gathered as an incidental part of a comprehensive national interview study of the characteristics of residential facilities and their residents. The study included 2271 retarded individuals in 236 residential facilities in the US. Facilities were selected through a 2-stage probability sample design in such a way that the probability of a facility's selection was proportionate to its size (number of residents) and so that the distribution of sample facilities across census regions and size classes was in close agreement with the distribution of facilities nationally. Interviews at 75 institutions and 161 private facilities were conducted between September 1978 and April 1979. Demographic information about individual residents, including date of birth, date of admission, previous type of residential placement, age, height, weight, diagnosed degree of retardation, and diagnosis of @entity302 , @entity2438 , or @entity1032 , was obtained from each resident's records. The staff @entity1 most familiar with each resident was then identified and interviewed about the resident. Care @entity1 were asked whether and for what purpose drugs were prescribed for each resident. 75.8% of institutionalized residents and 54.3% of community facility residents were reported to be receiving at least 1 type of regularly prescribed medication. Percentages reported for specific drugs should be considered minimums, because drug names were not always elicited if the drug's purpose was known. Drugs not named, but reported to be prescribed for a chronic health condition, @entity302 , a @entity146 problem, for sleeping, or for birth control, were listed with "other" within tentative categories. Multiple regression was used to examine the relationships among drug use and several resident and facility characteristics. The institutionalized and community-based samples were combined for these analyses. Drugs reported to be prescribed for chronic health problems most frequently were used by older, nonambulatory residents who had health problems. Use of antiepilepsy drugs was most closely associated with a history of @entity410 . Only 1.3% of community facility residents and 1.6% of institutionalized residents whose records did not document @entity302 were reported to be receiving antiepilepsy drugs. Psychotropic drugs most often were prescribed for residents with @entity146 or for those with a recorded mention of @entity1032 or @entity2438 . Older, heavier, and more severely retarded residents also were more likely to receive psychotropic drugs. Contraceptive drugs were predicted by age, sex, ability, and minority status. Younger and @entity1032 @entity1 were more likely to receive birth control methods, as were minorities.

title: A national study of prescribed drugs in institutions and community residential facilities for @entity1032 XXXX .

answer: @entity1 :: (9606,Species) :: ['people']


abstract: BACKGROUND AND PURPOSE: The relationships between @entity75 visible on imaging and cognition are complex. We explored the possibility that the cerebral cortical volume mediated these relationships. METHODS: Total of 1906 nondemented @entity1 (59% @entity1 ; 25% African-American; mean age, 76.6 years) in the @entity731 Risk in Communities (ARIC) study underwent cognitive assessments, risk factor assessments, and quantitative MRI for @entity62 ( @entity62 ) and @entity1188 . The Freesurfer imaging analysis pipeline was used to determine regional cerebral volumes. We examined the associations of cognitive domain outcomes with cerebral volumes (hippocampus and separate groups of posterior and frontal cortical regions of interest) and cerebrovascular imaging features (presence of large or small cortical/subcortical @entity1188 and @entity62 volume). We performed mediation pathway analyses to assess the hypothesis that hippocampal and cortical volumes mediated the associations between cerebrovascular imaging features and cognition. RESULTS: In unmediated analyses, @entity62 and @entity1188 were both associated with worse psychomotor speed/executive function. In mediation analyses, @entity62 and @entity1188 associations on psychomotor speed/executive function were significantly attenuated, but not abolished, by the inclusion of the posterior cortical regions of interest volume in the models, and the @entity1188 on psychomotor speed/executive function association were attenuated, but not abolished, by inclusion of the frontal cortical regions of interest volume. CONCLUSIONS: Both @entity62 and @entity1188 were associated with cortical volume, and both lesions were also associated with cognitive performance, implying shared pathophysiological mechanisms. Although cross-sectional, our findings suggest that @entity62 and @entity1188 could be proxies for clinically covert processes that directly damage cortical regions. Microinfarcts are 1 candidate for such a clinically covert process.

title: Vascular Imaging Abnormalities and Cognition: Mediation by Cortical Volume in Nondemented Individuals: XXXX Risk in Communities-Neurocognitive Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebrovascular lesions']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarcts', 'infarct']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerosis']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['WMH', 'white matter hyperintensities']

answer: @entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']


abstract: UNASSIGNED: Infiltration of @entity5 with effector T cells is positively associated with therapeutic efficacy and @entity1 survival. However, the mechanisms underlying effector T-cell trafficking to the @entity5 microenvironment remain poorly understood in @entity1 with @entity694 . The polycomb repressive complex 2 (PRC2) is involved in @entity5 progression, but the regulation of @entity5 immunity by epigenetic mechanisms has yet to be investigated. In this study, we examined the relationship between the repressive PRC2 machinery and effector T-cell trafficking. We found that PRC2 components and demethylase @entity45938 -mediated histone H3 @entity376 27 trimethylation (H3K27me3) repress the expression and subsequent production of @entity1198 -type chemokines @entity373 and @entity371 , mediators of effector T-cell trafficking. Moreover, the expression levels of PRC2 components, including @entity16719 , @entity38612 , and EED, were inversely associated with those of @entity404 , @entity405 , and @entity1198 -type chemokines in @entity1 @entity694 tissue, and this expression pattern was significantly associated with @entity1 survival. Collectively, our findings reveal that PRC2-mediated epigenetic silencing is not only a crucial oncogenic mechanism, but also a key circuit controlling @entity5 immunosuppression. Therefore, targeting epigenetic programs may have significant implications for improving the efficacy of current @entity5 immunotherapies relying on effective T-cell-mediated immunity at the @entity5 site. @entity5 Res; 76(2); 275-82.   2015 AACR.

title: PRC2 Epigenetically Silences @entity1198 -Type Chemokines to Suppress Effector T-Cell Trafficking in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors', 'Cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

answer: @entity694 :: (MESH:D003110,Disease) :: ['Colon Cancer']


abstract: UNASSIGNED: Infiltration of @entity5 with effector T cells is positively associated with therapeutic efficacy and @entity1 survival. However, the mechanisms underlying effector T-cell trafficking to the @entity5 microenvironment remain poorly understood in @entity1 with @entity694 . The polycomb repressive complex 2 (PRC2) is involved in @entity5 progression, but the regulation of @entity5 immunity by epigenetic mechanisms has yet to be investigated. In this study, we examined the relationship between the repressive PRC2 machinery and effector T-cell trafficking. We found that PRC2 components and demethylase @entity45938 -mediated histone H3 @entity376 27 trimethylation (H3K27me3) repress the expression and subsequent production of @entity1198 -type chemokines @entity373 and @entity371 , mediators of effector T-cell trafficking. Moreover, the expression levels of PRC2 components, including @entity16719 , @entity38612 , and EED, were inversely associated with those of @entity404 , @entity405 , and @entity1198 -type chemokines in @entity1 @entity694 tissue, and this expression pattern was significantly associated with @entity1 survival. Collectively, our findings reveal that PRC2-mediated epigenetic silencing is not only a crucial oncogenic mechanism, but also a key circuit controlling @entity5 immunosuppression. Therefore, targeting epigenetic programs may have significant implications for improving the efficacy of current @entity5 immunotherapies relying on effective T-cell-mediated immunity at the @entity5 site. @entity5 Res; 76(2); 275-82.   2015 AACR.

title: PRC2 Epigenetically Silences XXXX -Type Chemokines to Suppress Effector T-Cell Trafficking in @entity694 .

answer: @entity1198 :: (51497,Gene) :: ['Th1']


abstract: During gaze shifts, @entity1 can use visual, vestibular, and proprioceptive feedback, as well as feedforward mechanisms, for stabilization against active and passive @entity910 . The contributions of feedforward and sensory feedback control, and the role of the cerebellum, are still under debate. To quantify these contributions, we increased the head moment of inertia in three groups (ten healthy, five chronic vestibular-loss and nine @entity6447 @entity1 ) while they performed large gaze shifts to flashed targets in darkness. This induces undesired @entity135 . Consequently, both active (desired) and passive (undesired) @entity910 had to be compensated for to stabilize gaze. All groups compensated for active and passive @entity910 , vestibular-loss @entity1 less than the other groups (P < 0.001, @entity1017 : vestibular-loss 0.23    0.09/0.43    0.12, healthy 0.80    0.17/0.83    0.15, @entity6447 .17/0.77    0.30, mean    SD). The compensation gain ratio against @entity717 was smaller than one in vestibular-loss @entity1 (0.54    0.10, P=0.001). Healthy and @entity6447 @entity1 did not differ in active and passive compensation. In summary, vestibular-loss @entity1 can better stabilize gaze against active than against passive @entity910 . Therefore, feedforward mechanisms substantially contribute to gaze stabilization. Proprioception alone is not sufficient (gain 0.2). Stabilization against active and passive @entity910 was not impaired in our @entity6447 @entity1 .

title: Gaze stabilization in chronic vestibular-loss and in XXXX : Interactions of feedforward and sensory feedback mechanisms.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patients']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head oscillations']

entities_list: @entity910 :: ('MESH:D004409', 'Disease') :: ['head movements']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['passive/active compensatory gains']

entities_list: @entity6447 :: ('MESH:D002524', 'Disease') :: ['cerebellar-ataxia 0.68    0', 'cerebellar ataxia', 'cerebellar-ataxia']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['passive and active movements']

answer: @entity6447 :: (MESH:D002524,Disease) :: ['cerebellar ataxia']


abstract: OBJECTIVES: @entity5 is the leading cause of @entity204 among Asian Americans. Chinese Americans comprise the largest Asian American ethnic group. Low health literacy (LHL) is associated with lower @entity5 screening rates, but this association has not been studied in Chinese Americans. We examined the relationship between LHL and meeting US Preventive Service Task Force (USPSTF) guidelines for cervical, colorectal and @entity0 screening among Chinese Americans. DESIGN: Observational study of Chinese respondents in the 2007 California Health Interview Survey, a population-based survey. Interview languages included English, Cantonese and Mandarin. SETTING: California, USA @entity1 : Chinese respondents in age/gender groupings appropriate for USPSTF @entity5 screening guidelines (cervical: @entity1 ages 21-65, n=632; colorectal: @entity1 or @entity1 ages 50-75, n=488; and breast: @entity1 ages 50-74, n=326). OUTCOMES: Relationships were tested using multivariable logistic regression models controlling for healthcare access and demographic factors, including limited English proficiency (LEP). The combined effects of having both LHL and LEP were specifically examined. LHL was measured by 2-items on perceived ease-of-use of written medical materials. All study variables were self-reported. RESULTS: @entity5 screening percentages among Chinese Americans were 77.8% for cervical, 50.9% for colorectal (47.9% for @entity1 and 54.2% for @entity1 ), and 85.5% for breast. LHL was associated with lower odds of meeting @entity0 screening guidelines (OR 0.41; 95% CI 0.20 to 0.82). Respondents with both LHL and LEP were significantly less likely to have up-to-date colorectal (OR 0.49; 95% CI 0.25 to 0.97) and @entity0 screening (OR 0.21; 95% CI 0.08 to 0.54) than those with neither health communication barrier. In all multivariable models, having seen a physician in the past year was a significant predictor of an up-to-date screening. CONCLUSIONS: In Chinese Americans, LHL and LEP were negatively associated with up-to-date breast and @entity14 screening, independent of a recent physician visit. Efforts to promote @entity5 screening among Chinese Americans should consider and address LHL, LEP and physician access barriers.

title: Low health literacy and XXXX screening among Chinese Americans in California: a cross-sectional analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'PARTICIPANTS', 'men']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: INTRODUCTION: Acute disseminated @entity1651 (ADEM) is an inflammatory, demyelinating @entity6220 whose clinical features, management and outcome are incompletely understood in Tunisian population. OBJECTIVE: To describe clinical, neuroimaging and laboratory features; treatment and outcome in a cohort of Tunisian @entity1 with ADEM. METHODS: We conducted a retrospective review of the medical records of all @entity1 attending the Department of @entity1 and Adolescent Neurology (Tunis) with ADEM between 2005 and 2015. Clinical, neuroimaging and laboratory features, therapeutic data and outcome were analyzed. RESULTS: There were 15  @entity1 (7  males and 8  females). The mean age at onset was 6.9years. Thirteen (86.6%) @entity1 had a prodromal event. The onset of @entity16 occurred within 17.6days (4-30). Limb weakness was the most common presenting symptom (53.3%). @entity21 was noticed in 6  @entity1 (40%). Initial MRI showed a deep gray matter involvement in 7  cases (46.6%). @entity2287 enhancement at acute stage was observed in only 2  @entity1 (13%). Cerebrospinal fluid findings did not show intrathecal oligoclonal bands. The use of high-dose IV @entity1667 followed by oral @entity479 taper was associated with rapid recovery. Additional treatment with intravenous immunoglobulin was necessary in 2  @entity1 . Complete recovery was obtained in 11  @entity1 (73.3%). A monophasic course was noticed in 14  cases. Only one @entity1 (5%) developed @entity15 . CONCLUSION: The high frequency of prodromal events and @entity21 in addition to the low rate of @entity2287 enhancement at acute stage seem to be the main features in our @entity1 . Larger ADEM multicenter cohort studies in Tunisia and North Africa could provide more detailed information about this entity.

title: [Acute disseminated XXXX in Tunisia: Report of a pediatric cohort].

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'children', 'patients', 'patient']

entities_list: @entity1667 :: ('MESH:D008775', 'Chemical') :: ['methylprednisolone']

entities_list: @entity6220 :: ('MESH:D020279', 'Disease') :: ['disorder of the central nervous system']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological symptoms']

entities_list: @entity1651 :: ('MESH:D004679', 'Disease') :: ['encephalomyelitis']

entities_list: @entity21 :: ('MESH:D001480', 'Disease') :: ['Extrapyramidal syndrome', 'extrapyramidal syndrome']

entities_list: @entity2287 :: ('MESH:D005682', 'Chemical') :: ['Gadolinium', 'gadolinium']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

answer: @entity1651 :: (MESH:D004679,Disease) :: ['encephalomyelitis']


abstract: The effect of @entity2644 ( @entity5579 ) was studied at four different doses in a group of 10 normal subjects. Blood levels of @entity5579 were assayed by gas chromatography and showed wide interindividual variations. Spontaneous brain electrical activity (EEG) was recorded from 8 leads and submitted to spectral analysis. Evoked responses (ER) to flashes, pattern reversals and clicks were averaged, and measured by their amplitude and variability. Several subjects presented marked side-effects (responders, R) and showed differences in many EEG parameters with respect to subjects without side-effects (non-responders, NR). A cluster analysis permitted to distinguish very clearly these two groups of subjects. The differences in the effects of @entity5579 between the R and NR groups involved mainly EEG, and appeared with a systematic topography over the scalp. Within the R group, many differences were observed as a function of the dose of @entity5579 ; they consisted mainly in a decrease of alpha and an increase of theta activity in the EEG, decrease of amplitude and increase of variability in the ER measures. These modifications had also a typical topography over the scalp. Finally, many variables of EEG (relative power only) were correlated with plasma level of @entity5579 , while no such correlation appeared for ER. These results are discussed in terms of individual sensitivity to drugs, relationships between EEG parameters and plasma level, and topographical differences in the effect of @entity5579 .

title: Relationship between plasma-levels of XXXX and effects on EEG and evoked potentials in healthy volunteers.

entities_list: @entity2644 :: ('MESH:D002746', 'Chemical') :: ['chlorpromazine']

answer: @entity2644 :: (MESH:D002746,Chemical) :: ['chlorpromazine']


abstract: UNASSIGNED: @entity195 ( @entity195 ) is the most common @entity303 in developed countries. Between the identified risk factors, one of the most important is the age. Its prevalence reaches 24  % in @entity1 and 33  % in @entity1 over 85  years. Increase in life expectancy, making it a serious public health problem. Prevention of @entity195 represents a major challenge to health. Given that @entity195 is largely dependent on the genetics of each @entity1 and uninterrupted progress of the age, which is try to make @entity1 aware that there are other factors that can alter your chance of developing the @entity195 and although currently not reduce, help is not increased in the near or distant future.The aim of this paper is to develop and evaluate a Web-Mobile application (Alzhe Alert) used to calculate the risk of Alzheimer's from a short questionnaire using a computer or mobile device, so that any user, without requiring computer skills, can access the website to estimate their risk of developing the disease in the coming years depending on their habits and daily basis activities. The users who have realized the questionnaire can to observe in a graph the result, and they will know which is at risk for Alzheimer's at present and over the next 50  years if they continue with the same habits and lifestyle. The objective is that the users can be aware of the risk they have different habits of life about their health. Currently, 243 users (84 @entity1 and 159 @entity1 ) of white race have completed the questionnaire. 76  % of the users have got a risk below the average.

title: What is Your Risk of Contracting XXXX ? A Telematics Tool Helps you to Predict it.

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'person', 'people', 'men']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease", 'Alzheimer disease']

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']


abstract: PURPOSE: We determined the ultrastructure of @entity19 @entity9504 , a model for @entity1 @entity9504 . METHODS: @entity9504 was induced in C57Bl/6j @entity19 by intrastromal injection of @entity1 adenovirus species D type 37 (HAdV-D37) with a heat-pulled, glass, micropipette needle under compressed air. At select time points after @entity281 , @entity19 were euthanized and their corneas removed, fixed, and sectioned at 70-nm thickness for electron microscopy. RESULTS: Injection of HAdV-D37 into the @entity19 @entity2687 placed virus predominantly in the pericellular corneal stromal matrix. @entity778 was seen bound to and entering stromal cells at 1 and 2 hours after @entity281 , respectively. Cell membrane transit by virus was seen to involve two distinct structures resembling caveolae and macropinosomes. However, later during @entity281 intracellular virus was not seen within membrane-bound organelles. By 8 hours after @entity281 , intracellular virus had accumulated into densely packed, perinuclear arrays. @entity778 disassembly was not obvious at any time point after @entity281 . Infiltrating neutrophils seen by one day after @entity281 had engulfed degraded stromal cells by 4 days after @entity281 . CONCLUSIONS: By transmission electron microscopy, injected HAdV-D37 readily enters stromal cells in the C57Bl/6j @entity19 @entity267 and induces @entity32 , as was shown previously by light microscopy. However, electron microscopy also revealed dense, static arrays of intracytoplasmic virus, suggesting a block in viral capsid disassembly and viral DNA nuclear entry. These findings may explain why @entity1 adenoviruses do not replicate in the @entity19 @entity2687 .

title: Ultrastructure of XXXX .

entities_list: @entity9504 :: ('MESH:D000257', 'Disease') :: ['Adenovirus keratitis', 'adenovirus keratitis']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['stromal inflammation']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity2687 :: ('MESH:D003316', 'Disease') :: ['corneal stroma']

answer: @entity9504 :: (MESH:D000257,Disease) :: ['adenovirus keratitis']


abstract: UNASSIGNED: The renin-angiotensin- @entity1369 system (RAAS) is an enzymatic cascade functioning in a paracrine and autocrine fashion. In animals and @entity1 , RAAS intrinsic to tissues modulates food intake, metabolic rate, @entity1720 , and insulin secretion. A large array of observations shows that dysregulation of RAAS in the @entity209 favors @entity164 2 @entity6 . Remarkably, angiotensin-converting enzyme inhibitors, suppressing the synthesis of @entity2178 ( @entity2178 ), and angiotensin receptor blockers, targeting the @entity2178 @entity164 1 receptor, prevent @entity6 in @entity1 with @entity101 or @entity63 . These drugs interrupt the negative feedback loop of @entity2178 on the RAAS cascade, which results in increased production of angiotensins. In addition, they change the tissue expression of RAAS components. Therefore, the concept of a dual @entity2270 of RAAS regarding @entity413 homeostasis has emerged. The RAAS deleterious @entity2270 increases the production of inflammatory cytokines and raises oxidative stress, exacerbating the insulin resistance and decreasing insulin secretion. The @entity2270 promotes adipogenesis, blocks the production of inflammatory cytokines, and lowers oxidative stress, thereby improving insulin sensitivity and secretion. Currently, drugs targeting RAAS are not given for the purpose of preventing @entity6 in @entity1 . However, we anticipate that in the near future the discovery of novel means to modulate the RAAS @entity2270 will result in a decisive therapeutic breakthrough.

title: Modulation of XXXX metabolism by the renin-angiotensin- @entity1369 system.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patients']

entities_list: @entity1369 :: ('MESH:D000450', 'Chemical') :: ['aldosterone']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic cardiopathy']

entities_list: @entity2178 :: ('183', 'Gene') :: ['ANG II', 'angiotensin II']

entities_list: @entity2270 :: ('MESH:C566610', 'Disease') :: ['axis', 'beneficial axis']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity1720 :: ('MESH:D007333', 'Disease') :: ['adiposity, insulin sensitivity']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: UNASSIGNED: The renin-angiotensin- @entity1369 system (RAAS) is an enzymatic cascade functioning in a paracrine and autocrine fashion. In animals and @entity1 , RAAS intrinsic to tissues modulates food intake, metabolic rate, @entity1720 , and insulin secretion. A large array of observations shows that dysregulation of RAAS in the @entity209 favors @entity164 2 @entity6 . Remarkably, angiotensin-converting enzyme inhibitors, suppressing the synthesis of @entity2178 ( @entity2178 ), and angiotensin receptor blockers, targeting the @entity2178 @entity164 1 receptor, prevent @entity6 in @entity1 with @entity101 or @entity63 . These drugs interrupt the negative feedback loop of @entity2178 on the RAAS cascade, which results in increased production of angiotensins. In addition, they change the tissue expression of RAAS components. Therefore, the concept of a dual @entity2270 of RAAS regarding @entity413 homeostasis has emerged. The RAAS deleterious @entity2270 increases the production of inflammatory cytokines and raises oxidative stress, exacerbating the insulin resistance and decreasing insulin secretion. The @entity2270 promotes adipogenesis, blocks the production of inflammatory cytokines, and lowers oxidative stress, thereby improving insulin sensitivity and secretion. Currently, drugs targeting RAAS are not given for the purpose of preventing @entity6 in @entity1 . However, we anticipate that in the near future the discovery of novel means to modulate the RAAS @entity2270 will result in a decisive therapeutic breakthrough.

title: Modulation of @entity413 metabolism by the renin-angiotensin- XXXX system.

answer: @entity1369 :: (MESH:D000450,Chemical) :: ['aldosterone']


abstract: UNASSIGNED: Summary OBJECTIVE: The aim of this prospective longitudinal investigation was to compare the relationship between the @entity1348 ( @entity1348 ) condyles and the temporal fossae by means of tomography before and after the orthodontic correction of Class II, division 1 @entity3232 using the activator appliance. MATERIALS AND METHODS: The final sample consisted of 26 consecutively treated Class II, division 1 @entity1 (19 @entity1 and 7 @entity1 with an average pre-treatment age of 11 years) who underwent orthodontic treatment by means of an activator appliance. Before treatment all @entity1 were free of signs and symptoms associated to @entity2956 . Bilateral tomographic records before and after treatment were taken and analyzed. Outlines of the condyle and temporal fossa were automatically determined by an edge-detection protocol, and the minimum joint space dimension was automatically measured every 2 degrees. For further analysis, the joint space was divided into anterior, superior, and posterior joint spaces. RESULTS: The average treatment time with the activator appliance was 366 days. In all subjects, activator treatment resulted in a Class I dental arch relationship. After activator treatment, no differences were found in the joint space measurements in any direction. Comparisons between the right and left condyles were not significantly different. CONCLUSIONS: Joint space dimension in Class II division I @entity1 was similar before and after treatment in both TMJs.

title: Changes in joint space dimension after the correction of Class II division 1 XXXX .

entities_list: @entity3232 :: ('MESH:D008310', 'Disease') :: ['malocclusion']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'girls', 'boys']

entities_list: @entity2956 :: ('MESH:D013705', 'Disease') :: ['TMJ disorders']

entities_list: @entity1348 :: ('MESH:D013706', 'Disease') :: ['TMJ', 'temporomandibular joint']

answer: @entity3232 :: (MESH:D008310,Disease) :: ['malocclusion']