abstract: The role of telomerase activity in @entity5 progression of @entity1821 is not well understood. Therefore, we investigated 72 @entity1821 of different histological subtypes for an association between telomeric lengths and telomerase activity, and assessed the association between the catalytic subunit @entity1 telomerase reverse transcriptase ( @entity2215 ) and its activator @entity517 . Telomeric repeat fragment lengths were determined using radioactive DNA-fingerprint analysis with the telomere-specific probe (TTAGGG)(3), whereas telomerase activity was ascertained using the non-radioactive TRAP-assay. To evaluate the expression of @entity2215 and @entity517 , we applied real-time RT-PCR using a LightCycler. Eight @entity5 were investigated by microdissection. The @entity1758 -proliferation index and @entity2215 and @entity517 protein expression were determined immunohistochemically. Genetic alterations showed a high degree of @entity5 specificity. Highly malignant myxoid/round cell @entity1821 showed the longest telomeres, the strongest telomerase activity, and the highest @entity2215 and @entity517 expression levels compared with the pure myxoid variants (p < 0.001), which are of low malignancy. @entity1821 was characterized by zero or low @entity2215 and @entity517 expression and telomerase activity, but long telomeres, underlining their different pathogenetic pathway. Elevated gene expression was accompanied by protein immunopositivity. @entity1758 -proliferation index did not correlate with other molecular markers. We conclude that @entity2215 and @entity517 expression are associated with telomerase activity in @entity1821 . Elevated @entity2215 and @entity517 expression as well as high telomerase activity play a role in the @entity5 progression of this @entity242 type. Nevertheless, each histological subtype of @entity1821 is defined by a specific molecular pattern. Telomerase activation is the most common pathway in @entity1821 maintaining telomeric length.

title: Elevated telomerase activity, @entity517 -, and @entity2215 mRNA expression: association with @entity5 progression in XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignant lipomatous tumours']


abstract: @entity4625 -gel-derived @entity3759 coatings are known to promote bonelike @entity692 formation on their surfaces in vitro and in vivo. @entity692 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity702 substrates with a @entity515 laser was studied in terms of the in vitro @entity78 -inducting properties. @entity515 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity692 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity78 formation can be adjusted locally by laser treatment. @entity78 is a bonelike @entity692 . The local treatment of sol-gel-derived coatings with a @entity515 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of XXXX formation on @entity3759 coatings on @entity702 via surface treatment with a @entity515 laser.

entities_list: @entity78 :: ('MESH:C020243', 'Chemical') :: ['calcium phosphate', 'Calcium phosphate']

entities_list: @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite', 'Hydroxyapatite']

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

answer: @entity78 :: (MESH:C020243,Chemical) :: ['calcium phosphate']


abstract: @entity4625 -gel-derived @entity3759 coatings are known to promote bonelike @entity692 formation on their surfaces in vitro and in vivo. @entity692 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity702 substrates with a @entity515 laser was studied in terms of the in vitro @entity78 -inducting properties. @entity515 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity692 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity78 formation can be adjusted locally by laser treatment. @entity78 is a bonelike @entity692 . The local treatment of sol-gel-derived coatings with a @entity515 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of @entity78 formation on @entity3759 coatings on XXXX via surface treatment with a @entity515 laser.

answer: @entity702 :: (MESH:D014025,Chemical) :: ['titanium']


abstract: @entity4625 -gel-derived @entity3759 coatings are known to promote bonelike @entity692 formation on their surfaces in vitro and in vivo. @entity692 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity702 substrates with a @entity515 laser was studied in terms of the in vitro @entity78 -inducting properties. @entity515 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity692 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity78 formation can be adjusted locally by laser treatment. @entity78 is a bonelike @entity692 . The local treatment of sol-gel-derived coatings with a @entity515 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of @entity78 formation on @entity3759 coatings on @entity702 via surface treatment with a XXXX laser.

answer: @entity515 :: (CHEBI:29334,Chemical) :: ['CO2']


abstract: @entity4625 -gel-derived @entity3759 coatings are known to promote bonelike @entity692 formation on their surfaces in vitro and in vivo. @entity692 integrates into bone tissue. In some clinical applications, the surface of an implant is simultaneously interfaced with soft and hard tissues, so it should match the properties of both. A new method is introduced for treating the coatings locally in a controlled manner. The local densification of sol-gel-derived titania coatings on @entity702 substrates with a @entity515 laser was studied in terms of the in vitro @entity78 -inducting properties. @entity515 -laser-treated multilayer coatings were compared with furnace-fired coatings prepared with the same recipe and previously shown to be bioactive. Additionally, local areas of furnace-fired multilayer coatings (previously shown to be bioactive in vitro) were further laser-treated to achieve various properties in the same implant. Topological surface properties were examined with atomic force microscopy. The formation of @entity692 was studied with Fourier transform infrared and scanning electron microscopy energy-dispersive X-ray analysis. The results show that @entity78 formation can be adjusted locally by laser treatment. @entity78 is a bonelike @entity692 . The local treatment of sol-gel-derived coatings with a @entity515 laser is a promising technique for creating implants with various properties to interface different tissues and a possible way of coating implants that do not tolerate furnace firing.

title: Local induction of @entity78 formation on XXXX coatings on @entity702 via surface treatment with a @entity515 laser.

answer: @entity3759 :: (CHEBI:32234,Chemical) :: ['TiO2']


abstract: BACKGROUND/AIM: Prediction and prevention of @entity3152 remain great challenge. It is important to include in everyday medical practice determination of certain markers that could help identifying pregnant @entity1 with @entity3152 . Insulinlike growth factor (IGF) is involved in the control mechanism of fetal and placental growth and development. The aim of this study was to examine the presence of @entity10116 ( @entity10116 ) in cervicovaginal secretion of pregnant @entity1 with symptoms of @entity3152 , but with apparently intact fetal membranes and to point out a possible application of the strip test for detection of phlGFBP-1 in diagnosis of preterm premature rupture of total membranes (PPROM) in everyday medical practice. METHODS: The study was performed at the Department for Obstetrics and Gynecology, Clinical Center of Vojvodina between October 2008 and May 2009. The study included 54 pregnant @entity1 between 20-35 @entity6677 ( @entity6677 ), divided into two groups: the study group (16 pregnant @entity1 with symptoms of @entity3152 that gave birth before 37 @entity6677 ) and the control group (38 pregnant @entity1 with the normal course of pregnancy that gave birth on term). In cervicovaginal secretion of the examined pregnant @entity1 the level of @entity10116 was determined by the immunochromatographic assay with monoclonal antibodies 6303 as a detecting antibody (Actim PROM test, Medix Biochemica, Kauniainen, Finland). RESULTS: Gestational age (GA) at delivery in the study group was 32.6 @entity6677 and in the control group it was 38.4 @entity6677 . Weight of newborns in the study group was 2,021 g and in the control group 3,430 g. IGFBP test was positive in 15 @entity1 (93.75%) of the study group, while in the control group it was positive only in 1 @entity1 (2.63%). CONCLUSION: Test on phIGFBP-1 in cervicovaginal mucus was positive in 93.75% @entity1 with @entity3152 , suggesting that this test could be used in diagnosis of silent rupture of fetal membranes and in prediction of @entity3152 .

title: The role of insulin-like growth factor in prediction and prevention of XXXX .

entities_list: @entity6677 :: ('MESH:D016640', 'Disease') :: ['weeks of gestation', 'WG']

entities_list: @entity10116 :: ('3484', 'Gene') :: ['insulin-like growth factor binding protein 1', 'IGFBP-1']

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm delivery', 'preterm labor']

answer: @entity3152 :: (MESH:D007752,Disease) :: ['preterm delivery']


abstract: While attempting to find a suitable crosslinking reagent for biopolymers, a naturally occurring @entity22271 (PA) obtained from grape seeds was selected to fix biological tissues. The @entity137 and crosslinking rate, reflected by the in vitro and in vivo degradation of fixed matrices has been studied. The shrinkage temperature of the fixed @entity291 pericardium increased from 66 to 86 degrees C. A @entity137 assay using fibroblast cultures revealed that PA is approximately 120 times less toxic than @entity3584 (GA), a currently used tissue stabilizer. In vitro degradation studies showed that fixed tissue was resistant to digestion by bacterial collagenase. Crosslinks between PA and tissues can be stabilized by decreasing the dielectric constant of the solution during storage. After subcutaneous implantation for periods ranging between 3 and 6 weeks, we found no apparent degradation of the GA- or PA-fixed tissues, whereas fresh tissue controls rapidly disintegrated. Beyond 6 weeks PA crosslinks began to degrade. More fibroblasts migrated and proliferated inside the PA-fixed implants compared with GA counterparts. Tissues crosslinked with PA manifested an enhanced collagen expression and deposition and did not calcify after implantation. GA, on the other hand, even after thorough rinsing continued to be cytotoxic, inhibited collagen synthesis and encouraged @entity730 . Collagen matrices crosslinked with PA are expected to be of value in the design of matrices that will encourage cell ingrowth and proliferation, which are temporary in nature, and that are intended to regenerate or replace missing tissues, which can delay the biogradation of collagen. As such they should be of significant value in the emerging field of tissue engineering.

title: XXXX : a natural crosslinking reagent for stabilizing collagen matrices.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity3584 :: ('MESH:D005976', 'Chemical') :: ['glutaraldehyde']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['dystrophic calcification']

entities_list: @entity22271 :: ('MESH:C013221', 'Chemical') :: ['proanthocyanidin']

answer: @entity22271 :: (MESH:C013221,Chemical) :: ['Proanthocyanidin']


abstract: Study of the histology, histochemistry, and fine structure of caudal epidermal regeneration in @entity38187 through restoration of a scaled form reveals that the processes involved resemble those known in lizards. Following establishment of a @entity7944 ( @entity7944 ), subjacent scale neogenesis involves epidermal downgrowths into the dermis. Although the process is extremely slow, and most new scales do not overlap, their epidermal coverings reestablish epidermal generation (EG) formation. As in lizards, the flat, alpha-keratogenic, @entity7944 cells contain lipids as revealed by their affinity for @entity38353 . A few mucous cells that store large PAS-positive mucus-like granules also occur in @entity7944 . During differentiation of @entity7944 cells, among the bundles of 70-nm tonofilaments are many lamellar bodies (LBs) and mucous granules (MGs) that discharge their contents into the cytoplasm and extracellular spaces producing a strongly PAS-positive keratinized tissue. @entity4890 with mucus is a primitive characteristic for amniote vertebrates, probably related to functions as a barrier to cutaneous water loss (CWL). As scale neogenesis begins, beneath the superficial @entity7944 appear 3-5 layers of irregularly shaped cells. These contain tonofilament bundles surrounded by small, round keratohyalin-like granules (KHLGs) and a keratinized matrix with beta-keratin packets and a 3-5-nm thick keratin granulation. This mixture of alpha- and beta-keratogenic capacities resembles that seen in the innermost cells of a normal @entity38187 epidermal generation. As in the latter, but in contrast to both normal and regenerating lizard epidermis, no definable shedding complex with interdigitating clear layer and oberhautchen cells occurs (Alibardi and Maderson, 2003). The tortuous boundaries, and merging beta-keratin packets, identify subjacent keratinizing cells as precursors of the typical stratified, squamous beta-layer seen in long-term regenerated caudal skin wherein the entire vertical sequence of epidermal layers resembles that of normal scales. The sequence of events in caudal epidermal regeneration in @entity4576 resembles that documented for lizards. Observed differences between posttrauma scale neogenesis and scale embryogenesis are responses to functional problems involved in, respectively, restoring, or forming, a barrier to CWL while accommodating rapid somatic growth.

title: Observations on the histochemistry and ultrastructure of regenerating caudal epidermis of the XXXX @entity38187 (Sphenodontida, Lepidosauria, Reptilia).

entities_list: @entity4890 :: ('MESH:D004814', 'Disease') :: ['Richness of epidermal lipids coexistent']

entities_list: @entity7944 :: ('MESH:C536309', 'Disease') :: ['WE', 'wound epithelium']

entities_list: @entity38187 :: ('8508', 'Species') :: ['Sphenodon punctatus', 'tuatara']

answer: @entity38187 :: (8508,Species) :: ['tuatara']


abstract: Study of the histology, histochemistry, and fine structure of caudal epidermal regeneration in @entity38187 through restoration of a scaled form reveals that the processes involved resemble those known in lizards. Following establishment of a @entity7944 ( @entity7944 ), subjacent scale neogenesis involves epidermal downgrowths into the dermis. Although the process is extremely slow, and most new scales do not overlap, their epidermal coverings reestablish epidermal generation (EG) formation. As in lizards, the flat, alpha-keratogenic, @entity7944 cells contain lipids as revealed by their affinity for @entity38353 . A few mucous cells that store large PAS-positive mucus-like granules also occur in @entity7944 . During differentiation of @entity7944 cells, among the bundles of 70-nm tonofilaments are many lamellar bodies (LBs) and mucous granules (MGs) that discharge their contents into the cytoplasm and extracellular spaces producing a strongly PAS-positive keratinized tissue. @entity4890 with mucus is a primitive characteristic for amniote vertebrates, probably related to functions as a barrier to cutaneous water loss (CWL). As scale neogenesis begins, beneath the superficial @entity7944 appear 3-5 layers of irregularly shaped cells. These contain tonofilament bundles surrounded by small, round keratohyalin-like granules (KHLGs) and a keratinized matrix with beta-keratin packets and a 3-5-nm thick keratin granulation. This mixture of alpha- and beta-keratogenic capacities resembles that seen in the innermost cells of a normal @entity38187 epidermal generation. As in the latter, but in contrast to both normal and regenerating lizard epidermis, no definable shedding complex with interdigitating clear layer and oberhautchen cells occurs (Alibardi and Maderson, 2003). The tortuous boundaries, and merging beta-keratin packets, identify subjacent keratinizing cells as precursors of the typical stratified, squamous beta-layer seen in long-term regenerated caudal skin wherein the entire vertical sequence of epidermal layers resembles that of normal scales. The sequence of events in caudal epidermal regeneration in @entity4576 resembles that documented for lizards. Observed differences between posttrauma scale neogenesis and scale embryogenesis are responses to functional problems involved in, respectively, restoring, or forming, a barrier to CWL while accommodating rapid somatic growth.

title: Observations on the histochemistry and ultrastructure of regenerating caudal epidermis of the @entity38187 XXXX (Sphenodontida, Lepidosauria, Reptilia).

answer: @entity38187 :: (8508,Species) :: ['Sphenodon punctatus']


abstract: The development of @entity177 after open heart surgery is associated with a high mortality. Thirteen @entity1 were treated with @entity400 ( @entity400 ) for @entity177 following open heart surgery since April 1999 to December 2001. The indication of @entity400 was blood purification in 8 @entity1 and water balance control in 5 @entity1 . Two @entity1 with hemodialysis (HD) before operation returned to usual HD early after operation, and discharged. One @entity1 died of severe @entity712 , and another @entity1 died of @entity295 and @entity881 . In these 2 @entity1 , @entity400 could not withdrawn. Seven @entity1 weaned from @entity400 1 to 19 days after operation. Five of 7 @entity1 discharged, but 2 @entity1 died of @entity385 4 month after operation. The remaining 2 @entity1 could not wean from @entity400 , and were introduced HD. Only 1 of 13 @entity1 had @entity548 tendency ( @entity2293 ). @entity400 did not influence the hemodynamic state and was very effective for the treatment of @entity177 in many @entity1 .

title: [Analysis of XXXX after open heart surgery].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity2293 :: ('MESH:D002305', 'Disease') :: ['cardiac tamponade']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure']

entities_list: @entity400 :: ('MESH:D014202', 'Disease') :: ['CHDF', 'continuous hemodiafiltration']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multi organ failure']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity400 :: (MESH:D014202,Disease) :: ['continuous hemodiafiltration']


abstract: @entity8719 -like lesions were induced in @entity35 by immunizing them with type II collagen. After seven months' immunization, the @entity35 were killed and processed for histologic study. We found @entity75 in the bony cochlea, vestibule, semicircular canal, and in the regions near the oval window and round window. The @entity75 in the otic capsules were similar to @entity1 @entity8719 and were characterized by the following types of microscopic appearances. 1) The classic type showed enlarged vascular spaces with congestion, macrophages, fibroblasts, and sometimes osteoclasts. 2) The fibrotic type showed vascular spaces filled with fibrous tissues. 3) The osteoporotic type had a porous appearance and was devoid of content. 4) The @entity3808 type showed bone spaces partially or entirely being replaced by new bone with blue mantles and a mosaic appearance. Some @entity75 showed a mixture of the above types. The findings suggest that this animal model may provide important information to help understand the process of @entity1 @entity8719 .

title: Type II collagen-induced XXXX -like lesions in @entity35 .

entities_list: @entity8719 :: ('MESH:D010040', 'Disease') :: ['otospongiosis', 'otosclerosis', 'Otospongiosis']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['spongiotic lesions', 'otospongiotic lesions']

entities_list: @entity3808 :: ('MESH:C538213', 'Disease') :: ['sclerotic']

answer: @entity8719 :: (MESH:D010040,Disease) :: ['otospongiosis']


abstract: @entity8719 -like lesions were induced in @entity35 by immunizing them with type II collagen. After seven months' immunization, the @entity35 were killed and processed for histologic study. We found @entity75 in the bony cochlea, vestibule, semicircular canal, and in the regions near the oval window and round window. The @entity75 in the otic capsules were similar to @entity1 @entity8719 and were characterized by the following types of microscopic appearances. 1) The classic type showed enlarged vascular spaces with congestion, macrophages, fibroblasts, and sometimes osteoclasts. 2) The fibrotic type showed vascular spaces filled with fibrous tissues. 3) The osteoporotic type had a porous appearance and was devoid of content. 4) The @entity3808 type showed bone spaces partially or entirely being replaced by new bone with blue mantles and a mosaic appearance. Some @entity75 showed a mixture of the above types. The findings suggest that this animal model may provide important information to help understand the process of @entity1 @entity8719 .

title: Type II collagen-induced @entity8719 -like lesions in XXXX .

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: Higher levels of lipoprotein(a) confer an increased risk for @entity301 ( @entity301 ). @entity2204 genotype ( @entity2204 ) also plays a role, the @entity2204 epsilon 4 allele being associated with @entity301 . Furthermore, higher Lp(a) concentrations are correlated with @entity2204 epsilon 4 allele presence. The study was performed to investigate the relationship of Lp(a) and @entity2204 with the functional status of coronary arteries as evaluated by @entity296 . @entity1 AND METHODS: We studied 70 @entity1 (27 F and 43 M; mean age: 55 +/- 6 yrs.) consecutively referred for @entity301 , and 50 normal sex and age-matched controls. Total @entity165 , LDL- @entity165 , HDL- @entity165 , @entity1674 , @entity1675 , @entity755 , Lp(a) levels (ELISA), Lp(a) isoforms (Immuno Blotting) and @entity2204 (PCR) were measured in all subjects. Only @entity301 @entity1 underwent a myocardial tomographic stress thallium scintigraphy (201Tl-SPECT); the SPECT pattern was classified as follows: no perfusion defects (unstable angina group = 1), reversible defects at stress images ( @entity63 group = 2), fixed defects ( @entity1188 group = 3). RESULTS: Lp(a) medians were significantly higher than controls in group 1 (p < 0.05), 2 (p < 0.001) and 3 (p = 0.00). Low molecular weight isoforms (B, S1, S2) were significantly more frequent in all @entity301 - @entity1 vs. controls (p < 0.05), whereas @entity2204 genotypes did not differ among controls and @entity1 . Multiple regression analysis showed family history (p < 0.001) to be the only independent predictive variable of @entity301 severity correlated to the scintigraphic pattern. CONCLUSION: Among the considered biological parameters in our @entity1 only Lp(a) plasma levels are related to the entity of @entity63 cardiac wall damage as evaluated by 201Tl-SPECT.

title: Correlation of lipoprotein(a) levels and myocardial stress thallium scintigraphy pattern in different entities of XXXX severity.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial scintigraphy']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic', 'ischemia']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity301 :: (MESH:D003327,Disease) :: ['CHD']


abstract: UNASSIGNED: In @entity5 @entity1 , oral nutrition is the preferred route of feeding since it is a significant part of the @entity1 's daily routine and contributes to the @entity1 's autonomy. It represents a privileged time to spend with family and friends, avoiding the tendency for isolation in these @entity1 . The acknowledgement that the prescribed diet is individualized, adapted and adequate to individual needs empowers the @entity1 with a feeling of control, and thus it is also a highly effective approach of psychological modulation. All these factors may potentially contribute to improve the @entity1 's quality of life and may modulate treatment morbidity. The referral to a nutrition professional responsible for the individualized dietary counseling should always be based on evidence-based decision-making plans. The implementation of individualized nutritional counseling should consider the common causes for a poor nutritional intake in elderly @entity5 @entity1 . A proper approach through counseling requires professionals with specific experience in both nutrition and oncology. Oral nutritional supplements are a simple and practical way to meet nutritional requirements when normal food intake is compromised. Ideally, oral nutritional supplements should be in addition to and not instead of meals. Supplements should be administered at a time which does not interfere with the appetite of the @entity1 . The administration after the meal theoretically potentiates the anabolic effect on protein metabolism. Supplements with high energy density (>1 kcal/ml) or enriched with x03C9;-3 @entity844 are probably the most effective.

title: Nutrition in XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: PURPOSE: The purpose of this study was to compare the clinical outcomes between the groups using Ray-Tracing ( @entity35 ) and Monte-Carlo (MC) calculation algorithms for stereotactic body radiotherapy (SBRT) of @entity2 . MATERIALS AND METHODS: Thirty-five @entity1 received SBRT with CyberKnife for 47 primary or metastatic @entity2 . @entity35 was used for 22 targets in 12 @entity1 , and MC for 25 targets in 23 @entity1 . Total dose of 48 to 60 Gy was prescribed in 3 to 5 fractions on median 80% isodose line. The response rate, local control rate, and @entity137 were compared between @entity35 and MC groups. RESULTS: The response rate was lower in the @entity35 group (77.3%) compared to the MC group (100%) (p = 0.008). The response rates showed an association with the mean dose to the gross @entity5 volume, which the doses were re-calculated with MC algorithm in both groups. However, the local control rate and @entity137 did not differ between the groups. CONCLUSIONS: The clinical outcome and @entity137 of lung SBRT between the @entity35 and MC groups were similar except for the response rate when the same apparent doses were prescribed. The lower response rate in the @entity35 group, however, did not compromise the local control rates. As such, reducing the prescription dose for MC algorithm may be performed but done with caution.

title: Comparing the clinical outcomes in stereotactic body radiotherapy for XXXX between Ray-Tracing and Monte-Carlo algorithms.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung tumors']


abstract: @entity1073 ( @entity1073 ) is believed to originate from a naive B cell. However, we recently demonstrated that a subset of @entity1073 displayed mutated V(H) genes. We also reported restricted use of certain V(H) genes. To assess the prognostic impact of these new findings, we performed V(H) gene analysis of 110 @entity1 , revealing that 18 (16%) @entity1 had mutated and 92 (84%) @entity1 had unmutated V(H) genes. Because the mutation rate was low in the mutated group (2.2%-6.7%), further investigation of the germline V(H) gene in T cells from 5 @entity1 with mutated V(H) genes was carried out; results showed that the unrearranged V(H) gene was identical to the published sequence. These data confirm that the base pair substitutions within the rearranged V(H) genes represent hypermutations, and indicate germinal center exposure. However, V(H) gene mutation status did not correlate with prognosis because there was no difference in clinical outcome between the unmutated and mutated groups. The most frequently used V(H) genes were V(H)3-21 (21 @entity1 ) and V(H)4-34 (19 @entity1 ). A novel finding was that V(H)3-21(+) @entity1073 almost exclusively expressed lambda light chains and displayed highly restricted use of the V(lambda)3-19 gene. V(H)3-21(+) @entity1 had longer median survival than the remaining @entity1 (53 vs 34 months; P =.03), but they tended to be younger at diagnosis. The combined use of V(H)3-21/V(lambda)3-19 suggests a possible role for antigen(s) in the pathogenesis of these @entity5 and indicates that V(H)3-21(+) @entity1 constitute a new @entity1073 entity.

title: Mutated VH genes and preferential VH3-21 use define new subsets of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity1073 :: ('MESH:D020522', 'Disease') :: ['Mantle cell lymphoma', 'MCL']

answer: @entity1073 :: (MESH:D020522,Disease) :: ['mantle cell lymphoma']


abstract: OBJECTIVE: Perturbations in emotional conflict adaptation, an implicit regulatory process, have been observed in adult @entity148 . However, findings remain inconsistent and restricted to adults. The current study compares conflict adaptation in youth and adults, with and without @entity148 . We predicted conflict adaptation would be present in the healthy but not the anxious groups. METHODS: In a clinic setting, 111 @entity1 (27 healthy youth, 22 anxious youth, 41 healthy adults, and 21 anxious adults) completed emotional and nonemotional conflict tasks. Groups did not differ (all p's >0.1) on intelligence quotient (IQ), gender, and socioeconomic status; age did not differ between healthy and anxious subjects in either age cohort. Separate four way mixed-design analyses of variance were conducted to test hypotheses regarding the influence of diagnosis, age group, and task type on accuracy (percent correct) and @entity137 ( @entity137 ) for conflict adaptation (incongruent trials preceded by incongruent vs. congruent trials) and conflict detection (incongruent vs. congruent trials). RESULTS: Measures of conflict adaptation did not interact with diagnosis or age. There was a significant main effect of conflict adaptation across the overall sample in the expected direction for accuracy, but not @entity137 . The well-replicated conflict detection effect also did emerge across tasks, with slower @entity137 and lower accuracy for incongruent than for congruent trials. These effects were greater for the emotional than for nonemotional tasks. Finally, there were age differences in accuracy-based conflict detection specific to the emotional task, for which the size of the effect was larger for youth than for adults. CONCLUSIONS: The current study of youth and adults did not replicate prior behavioral findings of failure to engage conflict adaptation in @entity148 . Therefore, more work is needed before widely adopting conflict adaptation paradigms as a standard neurocognitive marker for @entity148 .

title: Emotional and Nonemotional Conflict Processing in Pediatric and Adult XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety disorders']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['RT', 'reaction time']

answer: @entity148 :: (MESH:D001008,Disease) :: ['Anxiety Disorders']


abstract: PURPOSE: We investigated the cumulative probability of @entity410 remission and relapse in an adult population with @entity302 and frequent @entity410 . In addition, we determined clinical predictors of remission and relapse in this population. METHODS: IN 2003, we identified 246 @entity1 at a single center with @entity302 defined as at least one @entity410 per month and failure of at least two antiepileptic drugs. These @entity1 were followed prospectively (cohort design). We examined the cumulative probability of @entity410 remission and relapse in this population using Kaplan-Meier methodology. Clinical predictors of remission and relapse were also evaluated using Cox regression analysis. KEY FINDINGS: The estimated cumulative probability of 12-month @entity410 remission was 34.6% at 7 years in the entire population and 33.4% when limited to those without surgery. The risk for relapse after a 12-month period of @entity410 remission was 71.2% at 5 years. Negative predictors of @entity410 remission included @entity245 , @entity6191 , duration of intractability, and number of antiepileptic drugs failed. @entity1625 was the only negative predictor of relapse. SIGNIFICANCE: Among @entity1 with @entity302 , 5% per year enter @entity410 remission even with a follow-up of 6 years. However, a substantial proportion of these @entity1 relapse after the first year following a remission. The large proportion of @entity1 entering a significant remission gives these @entity1 hope; however, caution should be advised when discussing the likelihood of future @entity410 .

title: Remission and relapse in a XXXX population followed prospectively.

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity1625 :: ('MESH:D004828', 'Disease') :: ['Localization-related epilepsy']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental delay']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['drug-resistant epilepsy']

entities_list: @entity6191 :: ('MESH:D004829', 'Disease') :: ['symptomatic generalized epilepsy syndrome']

answer: @entity302 :: (MESH:D004827,Disease) :: ['drug-resistant epilepsy']


abstract: PURPOSE: Evidence from the pediatric population exists for the efficacy of ketogenic diets in reducing @entity410 frequency in @entity1 with intractable @entity302 . Recent evidence suggests that a Modified Atkins Diet may be a beneficial form of cotherapy for adult @entity1 with pharmacoresistant @entity302 . METHODS: A prospective, open-label study was performed of adults > 18 years of age with pharmacoresistant @entity302 . Carbohydrates were restricted to 20 g/day. Fluids and calories from protein and fat were allowed ad libitum. KEY FINDINGS:     Eighteen @entity1 , ages 18-55 years, were initially enrolled. Using an intent-to-treat analysis, 12% had a >50% @entity410 reduction after 3 months; 28% after 6 months, and 21% after 12 months. Response at 3 months predicted response at 12 months in 79% of @entity1 . The mean decrease in weight was 10.9 kg and the mean decrease in body mass index (BMI) was 3.8, p = 0.01. Fourteen of 18 @entity1 (78%) completed 12 months of this diet. @entity1 experienced a decrease in @entity1674 from (mean) 1.22 to 0.9 mm (p = 0.02). SIGNIFICANCE: The Modified Atkins Diet demonstrates modest efficacy as cotherapy for some adults with pharmacoresistant @entity302 and may be also helpful for @entity353 . Financial and logistical barriers were significant factors for those who declined enrollment and for those who discontinued the study.

title: Efficacy and tolerability of the modified Atkins diet in adults with pharmacoresistant XXXX : a prospective observational study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: We have made use of isogeneic anti-idiotopic (anti-Id) monoclonal antibodies (mAb to modify experimental autoimmune @entity1737 (EAMG) in Lewis @entity35 . High-avidity anti-Id mAb HC-4A (Kd = 0.1 nM) and HC-29 (Kd = 0.1 nM) were produced against an anti- @entity934 receptor (anti- @entity9176 ) Lewis- @entity35 mAb 132A (Kd = 0.34 nM) that is capable of inducing passive-transfer EAMG. mAb HC-4A and HC-29 define separate framework Id cross-reactive with anti- @entity9176 mAb recognizing different @entity9176 epitopes. Animals were preinjected i.p. with either anti-Id mAb or with control mAb and then were actively immunized 2 wk later with purified @entity9176 . All animals had elevated total serum anti- @entity9176 antibody titers, despite the absence of @entity425 or decremental electromyographic findings. Animals preinjected with control mAb developed serum anti- @entity9176 titers of 1.34 +/- 0.29 microM (mean +/- SEM) and reduced muscle @entity9176 content to 30 percent of normal. Animals injected with 0.5 mg/kg of either anti-Id had significantly lower serum anti- @entity9176 titers, 0.55 +/- 0.1, p less than 0.05, and normal muscle @entity9176 content. Both the 132A Id and the anti-Id complementary to 132A were detected in the serum of all of the animals preinjected with this dose of either anti-Id HC-29 or HC-4A, whereas both were detected in a much smaller percentage of the animals receiving control mAb. These results show that pretreatment with anti-Id not only perturbs this Id-anti-Id network, but also suppresses the overall polyclonal anti- @entity9176 response with resultant protection of actively immunized animals from EAMG.

title: Suppression of development of experimental autoimmune XXXX with isogeneic monoclonal anti-idiotopic antibody.

entities_list: @entity1737 :: ('MESH:D009157', 'Disease') :: ['myasthenia gravis']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity1737 :: (MESH:D009157,Disease) :: ['myasthenia gravis']


abstract: UNASSIGNED: OBJECT The association between age and outcomes following @entity439 treatment with flow diverters such as the Pipeline Embolization Device (PED) have not been well established. Using the International Retrospective Study of the Pipeline Embolization Device (IntrePED) registry, the authors assessed the age-related clinical outcomes of @entity1 undergoing @entity439 with the PED. METHODS @entity1 with @entity439 in the IntrePED registry were divided into 4 age groups:  <= 50, 51-60, 61-70, and > 70 years old. The rates of the following postoperative complications were compared between age groups using chi-square tests: spontaneous @entity397 , @entity932 ( @entity932 ), @entity385 , parent @entity2791 , @entity129 , @entity16 , @entity16 , combined @entity16 and mortality, and all-cause mortality. The association between age and these complications was tested in a multivariate logistic regression analysis adjusted for sex, number of PEDs, and @entity439 size, location, and type. RESULTS Seven hundred eleven @entity1 with 820 @entity439 were included in this study. Univariate analysis demonstrated no significant difference in @entity932 rates across age groups (lowest 1.0% for @entity1  <= 50 years old and highest 5.0% for @entity1 > 70 years old, p = 0.097). There was no difference in @entity385 rates (lowest 3.6% for @entity1  <= 50 years old and highest 6.0% for @entity1 50-60 years old, p = 0.73). Age > 70 years old was associated with higher rates of @entity16 ; @entity1 > 70 years old had @entity16 rates of 7.4% compared with 3.3% for @entity1 61-70 years old, 2.7% for @entity1 51-60 years old, and 0.5% for @entity1  <= 50 years old (p = 0.006). On multivariate logistic regression analysis, increasing age was associated with higher odds of combined @entity16 and mortality (odds ratio 1.02, 95% confidence interval 1.00-1.05; p = 0.03). CONCLUSIONS Increasing age is associated with higher @entity16 and mortality after Pipeline embolization of @entity438 . However, the overall complication rates of PED treatment in this group of highly selected elderly @entity1 (> 70 years) were acceptably low, suggesting that age alone should not be considered an exclusion criterion when considering treatment of @entity438 with the PED.

title: Age-related outcomes following intracranial XXXX treatment with the Pipeline Embolization Device: a subgroup analysis of the IntrePED registry.

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['cranial neuropathy']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage', 'ICH']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological mortality', 'neurological morbidity']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['artery stenosis']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm embolization', 'aneurysm', 'unruptured aneurysms']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity439 :: (MESH:D000783,Disease) :: ['aneurysm']


abstract: INTRODUCTION: @entity3852 is a rare malignant cutaneous @entity5 that is locally invasive and frequently metastasizes to lymph nodes, liver, lungs, bone and brain. The incidence of @entity3852 has increased in the past three decades. CASE PRESENTATION: A 65-year-old Caucasian @entity1 presented with a sudden onset of severe @entity10 and a three-month history of balance disturbance. Magnetic resonance imaging revealed a large meningeal @entity3 . The radiologic workup showed retroperitoneal and inguinal lymph node @entity3 . Biopsy of the inguinal lymph nodes showed @entity3852 . Biopsy from three different suspected @entity272 revealed no @entity3852 , and the primary @entity3852 remained unknown. @entity3 , new axillary lymph node @entity3 , and intraspinal (epidural and intradural) @entity3 were detected within six, seven and eight months, respectively, from the start of symptoms despite treating the intracranial @entity3 with gamma knife and the abdominal @entity3 with surgical dissection and external radiotherapy. This indicates the aggressive nature of the disease. CONCLUSION: To the best of our knowledge, this is the first report in the literature of an intracranial meningeal @entity3 of @entity3852 treated with gamma knife and of intraspinal intradural @entity3852 . Despite good initial response to radiotherapy, recurrence and occurrence of new @entity3 are common in @entity3852 .

title: Extensive central nervous system XXXX : a case report and review of the literature.

entities_list: @entity3852 :: ('MESH:D015266', 'Disease') :: ['metastases of Merkel cell carcinoma', 'site of Merkel cell carcinoma', 'Merkel cell carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases', 'Leptomeningeal metastases']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity3852 :: (MESH:D015266,Disease) :: ['involvement in Merkel cell carcinoma']


abstract: BACKGROUND: The prevalence of peanut @entity566 appears to have increased in recent decades. Other than a family history of peanut @entity566 and the presence of atopy, there are no known risk factors. METHODS: We used data from the Avon Longitudinal Study of Parents and @entity1 , a geographically defined cohort study of 13,971 preschool @entity1 , to identify those with a convincing history of peanut @entity566 and the subgroup that reacted to a double-blind peanut challenge. We first prospectively collected data on the whole cohort and then collected detailed information retrospectively by interview from the parents of @entity1 with peanut reactions and of @entity1 from two groups of controls (a random sample from the cohort and a group of @entity1 whose mothers had a history of @entity484 and who had had @entity484 themselves in the first six months of life). RESULTS: Forty-nine @entity1 had a history of peanut @entity566 ; peanut @entity566 was confirmed by peanut challenge in 23 of 36 @entity1 tested. There was no evidence of prenatal sensitization from the maternal diet, and peanut-specific IgE was not detectable in the cord blood. @entity16244 was independently associated with intake of soy milk or soy formula (odds ratio, 2.6; 95 percent confidence interval, 1.3 to 5.2), @entity1910 and skin creases (odds ratio, 2.6; 95 percent confidence interval, 1.4 to 5.0), and oozing, crusted @entity1910 (odds ratio, 5.2; 95 percent confidence interval, 2.7 to 10.2). Analysis of interview data showed a significant independent relation of @entity16244 with the use of skin preparations containing peanut oil (odds ratio, 6.8; 95 percent confidence interval, 1.4 to 32.9). CONCLUSIONS: Sensitization to peanut protein may occur in @entity1 through the application of peanut oil to inflamed skin. The association with soy protein could arise from cross-sensitization through common epitopes. Confirmation of these risk factors in future studies could lead to new strategies to prevent sensitization in @entity1 who are at risk for subsequent peanut @entity566 .

title: Factors associated with the development of XXXX in childhood.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children', 'infants']

entities_list: @entity1910 :: ('MESH:D005076', 'Disease') :: ['rash over joints', 'rash']

entities_list: @entity16244 :: ('MESH:D021183', 'Disease') :: ['peanut allergy', 'Peanut allergy']

answer: @entity16244 :: (MESH:D021183,Disease) :: ['peanut allergy']


abstract: UNASSIGNED: So far, associations between serotonergic neurotransmission pathways and suicidality have been reported. The aim of our study was to investigate the role of genetic polymorphisms and gene-gene interactions of the 5- @entity1873 and the 5- @entity7601 gene on suicide risk and/or a personal history of suicide attempts. A total of 374 major @entity308 @entity1 , adequately treated with antidepressants for at least 4 weeks, were collected in the context of a European multicentre study on treatment-resistant @entity308 . We assessed suicidality using the Mini International Neuropsychiatric Interview and the Hamilton Rating Scale for @entity308 (HAM-D). Treatment response was defined as HAM-D <=17 and remission as HAM-D <=7 after 4 weeks of adequate antidepressant treatment. The 5- @entity1873 @entity41512 ( @entity72430 ) single @entity4334 polymorphism (SNP) and the 5- @entity7601 @entity42266 , @entity33834 , @entity72431 and @entity72432 SNPs were selected for genotyping. Using logistic regression analyses, no association (P<0.05) could be found between any SNP and neither suicide risk nor personal history of suicide attempts. Interactions between 5HTR1A @entity41512 and 5HTR2A @entity33834 in suicide risk, and 5 @entity1873 @entity41512 and 5 @entity7601 @entity72431 in a personal history of suicide attempts have been reported (P=0.027 and 0.036, respectively); however, the results did not survive multiple testing correction. In conclusion, our study shows no association between 5HTR1A or 5 @entity7601 gene polymorphisms and both current suicide risk and personal history of suicide attempts. In addition, epistatic effects of 5HTR1A and 5 @entity7601 genes on suicidal behaviour were not significant, although sample size limitations do not allow definitive conclusions.

title: The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in XXXX @entity1 with insufficient response to treatment - a European multicentre study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depressive disorder', 'depression']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressed']


abstract: UNASSIGNED: So far, associations between serotonergic neurotransmission pathways and suicidality have been reported. The aim of our study was to investigate the role of genetic polymorphisms and gene-gene interactions of the 5- @entity1873 and the 5- @entity7601 gene on suicide risk and/or a personal history of suicide attempts. A total of 374 major @entity308 @entity1 , adequately treated with antidepressants for at least 4 weeks, were collected in the context of a European multicentre study on treatment-resistant @entity308 . We assessed suicidality using the Mini International Neuropsychiatric Interview and the Hamilton Rating Scale for @entity308 (HAM-D). Treatment response was defined as HAM-D <=17 and remission as HAM-D <=7 after 4 weeks of adequate antidepressant treatment. The 5- @entity1873 @entity41512 ( @entity72430 ) single @entity4334 polymorphism (SNP) and the 5- @entity7601 @entity42266 , @entity33834 , @entity72431 and @entity72432 SNPs were selected for genotyping. Using logistic regression analyses, no association (P<0.05) could be found between any SNP and neither suicide risk nor personal history of suicide attempts. Interactions between 5HTR1A @entity41512 and 5HTR2A @entity33834 in suicide risk, and 5 @entity1873 @entity41512 and 5 @entity7601 @entity72431 in a personal history of suicide attempts have been reported (P=0.027 and 0.036, respectively); however, the results did not survive multiple testing correction. In conclusion, our study shows no association between 5HTR1A or 5 @entity7601 gene polymorphisms and both current suicide risk and personal history of suicide attempts. In addition, epistatic effects of 5HTR1A and 5 @entity7601 genes on suicidal behaviour were not significant, although sample size limitations do not allow definitive conclusions.

title: The impact of serotonin receptor 1A and 2A gene polymorphisms and interactions on suicide attempt and suicide risk in @entity308 XXXX with insufficient response to treatment - a European multicentre study.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIM: No tools are currently available in France, for the detection of @entity2438 without @entity1032 (high functioning @entity2438 and @entity13104 here referred as TED SDI). Use of screening tests by first-line clinicians would allow better detection of @entity1 who are likely to display such difficulties and to improve @entity1 ' care. In England, 3 questionnaires have been evaluated: Autism Spectrum Quotient (AQ), Empathy Quotient (EQ), and Systemizing Quotient (SQ). This is the translation and evaluation of 3 questionnaires in France for TED SDI and control adolescents. METHODS: The translation of the questionnaires into French required two simultaneous translations, two back-translations and two consensus meetings. This is a cross-sectional study comparing scores obtained with the three AQ, EQ and SQ questionnaires. These questionnaires were completed by the parents of four groups of adolescents 11-18 years: 100 TED SDI adolescents (50 with IQ >=  85 and 50 with 70 <=IQ<85), 50 adolescents with another @entity146 (TP) and 200 control adolescents (T). RESULTS: 580 questionnaires have been sent to 40 recruiting centres. By the 28th of February, 2010, 277 completed questionnaires were received completed (TED SDI: 70 (70%); TP: 25 (50%) et T: 182 (91%)). In the control group, 92 @entity1 (mean 14.4  1.7 years) and 66 @entity1 (14.5  1.7 years) were recruited. In the TED SDI group, 4 @entity1 (14.3  2.4 years) and 42 @entity1 (14.5  1.7 years) were recruited. One @entity1 (81) and 6 @entity1 (72.2  7.7) have an IQ between 70 and 85, and 3 @entity1 (95.3  4.2) and 36 @entity1 (102.9  12) have an IQ higher than 85. In the TP group, 9 @entity1 (15.9  1.7 years) and 4 @entity1 (15.8  1.9 years) were recruited. CONCLUSION: The aim of this study is to make the AQ, EQ and SQ questionnaires available in French for French speaking clinicians. This study will allow a rigorous evaluation of the usefulness of the AQ questionnaire in the screening of TED SDI in adolescents.

title: [French version of screening questionnaire for high-functioning XXXX or @entity13104 in adolescent: Autism Spectrum Quotient, Empathy Quotient and Systemizing Quotient. Protocol and questionnaire translation].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girl', 'patients', 'girls', 'boys']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorder']

entities_list: @entity13104 :: ('MESH:D020817', 'Disease') :: ['Asperger syndrome']

answer: @entity2438 :: (MESH:D001321,Disease) :: ['autism']


abstract: AIM: No tools are currently available in France, for the detection of @entity2438 without @entity1032 (high functioning @entity2438 and @entity13104 here referred as TED SDI). Use of screening tests by first-line clinicians would allow better detection of @entity1 who are likely to display such difficulties and to improve @entity1 ' care. In England, 3 questionnaires have been evaluated: Autism Spectrum Quotient (AQ), Empathy Quotient (EQ), and Systemizing Quotient (SQ). This is the translation and evaluation of 3 questionnaires in France for TED SDI and control adolescents. METHODS: The translation of the questionnaires into French required two simultaneous translations, two back-translations and two consensus meetings. This is a cross-sectional study comparing scores obtained with the three AQ, EQ and SQ questionnaires. These questionnaires were completed by the parents of four groups of adolescents 11-18 years: 100 TED SDI adolescents (50 with IQ >=  85 and 50 with 70 <=IQ<85), 50 adolescents with another @entity146 (TP) and 200 control adolescents (T). RESULTS: 580 questionnaires have been sent to 40 recruiting centres. By the 28th of February, 2010, 277 completed questionnaires were received completed (TED SDI: 70 (70%); TP: 25 (50%) et T: 182 (91%)). In the control group, 92 @entity1 (mean 14.4  1.7 years) and 66 @entity1 (14.5  1.7 years) were recruited. In the TED SDI group, 4 @entity1 (14.3  2.4 years) and 42 @entity1 (14.5  1.7 years) were recruited. One @entity1 (81) and 6 @entity1 (72.2  7.7) have an IQ between 70 and 85, and 3 @entity1 (95.3  4.2) and 36 @entity1 (102.9  12) have an IQ higher than 85. In the TP group, 9 @entity1 (15.9  1.7 years) and 4 @entity1 (15.8  1.9 years) were recruited. CONCLUSION: The aim of this study is to make the AQ, EQ and SQ questionnaires available in French for French speaking clinicians. This study will allow a rigorous evaluation of the usefulness of the AQ questionnaire in the screening of TED SDI in adolescents.

title: [French version of screening questionnaire for high-functioning @entity2438 or XXXX in adolescent: Autism Spectrum Quotient, Empathy Quotient and Systemizing Quotient. Protocol and questionnaire translation].

answer: @entity13104 :: (MESH:D020817,Disease) :: ['Asperger syndrome']


abstract: BACKGROUND: @entity810 ( @entity810 ), requiring dialysis ( @entity810 -d), develops in 1-5% of @entity1 undergoing cardiac surgery and is associated with higher in-hospital mortality. Age is one of the known risk factors for the development of @entity810 . As the ageing population is increasing, the nephrologist will be faced with a large population of elderly @entity1 requiring dialysis following cardiac surgery. The aim of our study was to evaluate the influence of age on and the risk factors for in-hospital mortality. METHODS: Eighty-two @entity1 with @entity810 following cardiac surgery and requiring dialysis between January 1997 and October 2001 were included. Two groups of @entity1 were studied: the younger population (<70 years, 42 @entity1 , mean age 59+/-10) and an elderly population (>/=70 years, 40 @entity1 , mean age 76+/-4). Severity of disease was evaluated using the @entity697 ( @entity697 ), the Liano score and the SHARF (Stuivenberg Hospital Acute @entity177 ) score. RESULTS: Overall mortality in the population with @entity810 -d was 56.1%. No difference in mortality rate was found between the younger (61.9%) and elderly @entity1 group (50.0%). The two groups were very similar in baseline and procedural characteristics with exception of body weight (P=0.02) and preoperative glomerular filtration rate (P=0.0001). No significant difference was found in the scoring systems between the old and the young ( @entity697 P=0.52; Liano P=0.96; SHARF T0 P=0.06; SHARF @entity72433 =0.15). Mortality in the elderly was significantly correlated with @entity551 before starting renal replacement therapy (RRT) (P=0.002), mechanical ventilation (P=0.002), presence of @entity177 ( @entity177 ) (P=0.0001) and higher scores in the severity models ( @entity697 : P=0.01; Liano: P<0.0001 and SHARF: P<0.0001). CONCLUSION: The outcome in the elderly requiring dialysis due to @entity810 post-cardiac surgery is comparable with the outcome in a younger population. No significant difference was found in severity of disease between the elderly and the younger. Variables predicting mortality in the elderly are the presence of @entity177 , mechanical ventilation and @entity551 24 h before starting RRT. These findings indicate that at the time the nephrologist is called for an elderly @entity1 requiring dialysis due to @entity810 following cardiac surgery, age per se is not a reason to withhold RRT.

title: Outcome in a post-cardiac surgery population with XXXX requiring dialysis: does age make a difference?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['Simplified Acute Physiology Score', 'SAPS']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['multiorgan failure', 'MOF', 'Renal Failure']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['Acute renal failure', 'ARF']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity72433 :: ('p|SUB|T|48|P', 'ProteinMutation') :: ['T48 P']

answer: @entity810 :: (MESH:D058186,Disease) :: ['acute renal failure']


abstract: PURPOSE:    To evaluate retrospectively the efficiency of our rehabilitation programme for @entity1 with @entity6038 . In total, 49 @entity1 were examined, 21 female and 28 male, the youngest in their late teens. @entity6038 is generally characterised by @entity73 , @entity854 , and @entity7298 . @entity1 are usually considerably adverse to any form of physical exercise, and despite hormonal therapy, weight control in adult @entity1 can be difficult. METHODS:    Four times a year, disease-specific residential programmes were organised, each lasting 4 weeks. The @entity1 were restricted to a 1500 Kcal diet. In addition, they were required to do 6.5   h of physical exercise daily, stamina being built up by using music therapy, psychomotor therapy, education and entertainment activities. RESULTS: BMI decreased by 2.1 average points in every residential session. For three @entity1 who attended our treatments regularly, a reduction of 8.9 points over 6 years was recorded. An attendance of at least three sessions per year seemed to be necessary to substantially reduce weight. CONCLUSIONS: A multidisciplinary approach and a daily calorie-counted diet can lead to significant @entity353 in teenage and adult @entity6038 @entity1 . This approach would also be suitable in treating @entity1 with other @entity28 with @entity1032 .

title: Specific treatment of XXXX through cyclical rehabilitation programmes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity syndromes']

entities_list: @entity7298 :: ('MESH:D006963', 'Disease') :: ['hyperphagia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['behavioural abnormalities']

entities_list: @entity6038 :: ('MESH:D011218', 'Disease') :: ['Prader-Willi Syndrome', 'PWS', 'Prader-Willi syndrome']

answer: @entity6038 :: (MESH:D011218,Disease) :: ['Prader-Willi syndrome']


abstract: Three lactating Holstein @entity291 , averaging 510 kg and fitted with T-type duodenal cannulae in the proximal duodenum, were in a 3 X 3 Latin-square experiment to measure digestion in forestomachs and whole tract of feed @entity1568 and neutral detergent fiber components as influenced by frequency of feeding. @entity291 were fed one diet containing 65% chopped grass legume hay, 26% cracked @entity4336 , and 8% @entity1460 meal. Mixed ration was fed either once daily, four times daily, or the concentrate portion of the diet was fed once daily and the forage portion four times. Ytterbium, as @entity72434 , was included with diets to allow calculation of flow rates of @entity62 . Assayed ratios of @entity1568 to @entity6135 in ruminal bacteria and duodenal digesta or fecal bacteria and feces were used to calculate duodenal and fecal bacterial @entity1568 flows respectively. Ratios of @entity1568 to @entity6135 in ruminal and fecal bacteria averaged 4.15 and 2.38 g/mmol. Apparent digestibility of organic matter in the forestomachs and whole tract averaged 43.7 and 66.4%. Forestomach and whole tract digestibility of cellulose, hemicellulose, and lignin averaged 56.1, 52.0, 14.7, and 58.7, 58.5, and 16.8. Bacterial @entity1568 flows averaged 255 and 91 g/day at the duodenum and in the feces. Bacterial @entity1568 yield in the rumen averaged 36.6 g/kg organic matter apparently digested in the forestomachs. Frequency of feeding had no effect on almost all measures and components of rumen and whole tract metabolism and digestion. For these intakes, frequency of feeding had little effect on feed intake and nutrient utilization.

title: Forestomach and whole tract digestibility for lactating dairy XXXX as influenced by feeding frequency.

entities_list: @entity6135 :: ('MESH:D003960', 'Chemical') :: ['diaminopimelic acid']

entities_list: @entity72434 :: ('MESH:C044841', 'Chemical') :: ['ytterbium chloride']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['duodenal and fecal dry matter']

answer: @entity291 :: (9913,Species) :: ['cows']


abstract: In adults untreated @entity66 ( @entity66 ) is associated with a wide variety of malignant complications. The overall mortality in @entity66 is approximately twice that of the general population. The excess @entity204 are due mainly to @entity706 . In Europe, only 26 cases of @entity66 and @entity5 in @entity1 have been published. There is evidence that @entity5 and @entity66 in @entity1 are underreported. We report a case of @entity3969 in a @entity1 who developed @entity66 . As a neonate the @entity1 had been successfully operated for @entity12878 . Gluten was introduced in his diet at age of 12 months. He developed @entity391 , @entity1661 . Up to the age of 16 months he had lost 1500 g and @entity3935 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity194 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity3969 accounts for 6% to 7% of all childhood @entity5 . There are no reports in MEDLINE about @entity66 in @entity1 who have been operated for the @entity5 . This seemed intriguing because prevalence of @entity1593 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in @entity1 with celiac disease. XXXX in a @entity1 operated for @entity3969 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'boy', 'child']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['coeliac disease', 'CD']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['intestinal lymphoma']

entities_list: @entity3935 :: ('MESH:D013958', 'Disease') :: ['coeliac crisis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour', 'cancer', 'malignancies']

entities_list: @entity1593 :: ('MESH:D002446', 'Disease') :: ['gluten-sensitive enteropathy']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal distention ad hypertransaminosaemia']

entities_list: @entity12878 :: ('MESH:D018201', 'Disease') :: ['congenital mesoblastic nephroma']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['villous atrophy']

entities_list: @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumour']

answer: @entity1593 :: (MESH:D002446,Disease) :: ['Gluten-sensitive enteropathy']


abstract: In adults untreated @entity66 ( @entity66 ) is associated with a wide variety of malignant complications. The overall mortality in @entity66 is approximately twice that of the general population. The excess @entity204 are due mainly to @entity706 . In Europe, only 26 cases of @entity66 and @entity5 in @entity1 have been published. There is evidence that @entity5 and @entity66 in @entity1 are underreported. We report a case of @entity3969 in a @entity1 who developed @entity66 . As a neonate the @entity1 had been successfully operated for @entity12878 . Gluten was introduced in his diet at age of 12 months. He developed @entity391 , @entity1661 . Up to the age of 16 months he had lost 1500 g and @entity3935 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity194 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity3969 accounts for 6% to 7% of all childhood @entity5 . There are no reports in MEDLINE about @entity66 in @entity1 who have been operated for the @entity5 . This seemed intriguing because prevalence of @entity1593 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in @entity1 with celiac disease. @entity1593 in a @entity1 operated for XXXX ].

answer: @entity3969 :: (MESH:D009396,Disease) :: ['Wilms tumour']


abstract: In adults untreated @entity66 ( @entity66 ) is associated with a wide variety of malignant complications. The overall mortality in @entity66 is approximately twice that of the general population. The excess @entity204 are due mainly to @entity706 . In Europe, only 26 cases of @entity66 and @entity5 in @entity1 have been published. There is evidence that @entity5 and @entity66 in @entity1 are underreported. We report a case of @entity3969 in a @entity1 who developed @entity66 . As a neonate the @entity1 had been successfully operated for @entity12878 . Gluten was introduced in his diet at age of 12 months. He developed @entity391 , @entity1661 . Up to the age of 16 months he had lost 1500 g and @entity3935 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity194 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity3969 accounts for 6% to 7% of all childhood @entity5 . There are no reports in MEDLINE about @entity66 in @entity1 who have been operated for the @entity5 . This seemed intriguing because prevalence of @entity1593 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in XXXX with celiac disease. @entity1593 in a @entity1 operated for @entity3969 ].

answer: @entity1 :: (9606,Species) :: ['children']


abstract: In adults untreated @entity66 ( @entity66 ) is associated with a wide variety of malignant complications. The overall mortality in @entity66 is approximately twice that of the general population. The excess @entity204 are due mainly to @entity706 . In Europe, only 26 cases of @entity66 and @entity5 in @entity1 have been published. There is evidence that @entity5 and @entity66 in @entity1 are underreported. We report a case of @entity3969 in a @entity1 who developed @entity66 . As a neonate the @entity1 had been successfully operated for @entity12878 . Gluten was introduced in his diet at age of 12 months. He developed @entity391 , @entity1661 . Up to the age of 16 months he had lost 1500 g and @entity3935 was diagnosed (IgAEMA titre 1:50 and in the duodenal biopsy specimen there was crypt hyperplastic total @entity194 ). Symptoms improved rapidly when gluten-free diet was initiated, and 4 years later, clinical and serological findings were normal. @entity3969 accounts for 6% to 7% of all childhood @entity5 . There are no reports in MEDLINE about @entity66 in @entity1 who have been operated for the @entity5 . This seemed intriguing because prevalence of @entity1593 calculated for Europe varies between 1/100 and 1/300.

title: [Cancer in @entity1 with celiac disease. @entity1593 in a XXXX operated for @entity3969 ].

answer: @entity1 :: (9606,Species) :: ['boy']


abstract: 1. The ability of the @entity742 to tolerate excess @entity2827 has been investigated by subjecting @entity742 to an intravenous infusion of a 10% solution of @entity2827 .2. Inulin and diodrast clearances failed to show any consistent changes in glomerular filtration rate but the effective renal plasma flow was slightly more. Plasma levels of @entity1372 and @entity2865 increased by 20-25% and @entity972 decreased by 30%. Urinary levels for @entity1372 and @entity2865 showed a corresponding increase and @entity972 excretion was reduced.3. The rates of re-absorption of @entity1372 and @entity2865 from the renal tubules were found to be proportional to their rates of filtration at the glomerulus, but this ratio was reduced after the hypertonic saline infusion. No such correlation could be established for @entity972 .4. Osmolar clearances indicated that continued re-absorption of osmotically free water from the kidney tubular fluid occurred during and after the hypertonic saline. Excretion of urine, hyperosmotic to plasma, was thus maintained and water conservation supported.5. Possible renal mechanisms associated with these effects are discussed.

title: The effect of an intravenous infusion of hypertonic saline on renal mechanisms and on electrolyte changes in XXXX .

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity2827 :: ('MESH:D012965', 'Chemical') :: ['sodium chloride']

answer: @entity742 :: (9940,Species) :: ['sheep']


abstract: The activities of four purified @entity1 growth factors: biosynthetic (recombinant) @entity2841 ( @entity2841 ); recombinant @entity2843 (EPA); natural and recombinant @entity1261 ( @entity1261 ); and natural @entity1261 alpha ( @entity1261 alpha), were compared on the growth of hematopoietic colonies from enriched populations of @entity1 marrow and blood progenitor cells. Conditioned medium from the Mo T cell line (MoCM) was used as a standard positive control. We found that activities of @entity2841 and @entity1261 alpha on the growth of hematopoietic colonies were indistinguishable; @entity1261 alpha is now believed to be identical to @entity2841 . Both factors were able to promote the growth of colonies derived from subpopulations of CFU-GM, BFU-E, and CFU-GEM. Colonies derived from CFU-GM and CFU-GEM in cultures stimulated by @entity2841 and @entity1261 alpha were much smaller than in cultures stimulated by MoCM. In contrast to previous reports in which less highly enriched progenitors were used as target cells, @entity1261 had no detectable activity on the growth of colonies derived from BFU-E or CFU-GEM but promoted the growth of a subpopulation of CFU-GM derived colonies. @entity1261 is now recognized to be identical to @entity1261 . The GM colonies in cultures stimulated by @entity1261 ( @entity1261 ) were much smaller than in cultures stimulated by MoCM. EPA had no detectable activity on either the size or number of colonies derived from CFU-GM, BFU-E, or CFU-GEM. Results from experiments using target cell populations of marrow fractions separated by velocity sedimentation and marrow populations following freezing suggested that @entity2841 ( @entity1261 alpha) and @entity1261 ( @entity1261 ) primarily affect the growth of relatively mature subpopulations of progenitor cells. It is clear from these results that additional factor(s) are present in MoCM that are necessary to stimulate CFU-GM, BFU-E, and CFU-GEM maximally in vitro.

title: Activities of four purified growth factors on highly enriched XXXX hematopoietic progenitor cells.

entities_list: @entity2843 :: ('7076', 'Gene') :: ['erythroid-potentiating activity']

entities_list: @entity2841 :: ('1437', 'Gene') :: ['granulocyte-macrophage colony-stimulating factor', 'GM-CSF']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: @entity1426 stimulated an increase in transmural electrical potential difference (p.d.) in @entity840 seminal vesicle tissue in vitro. Pretreatment with @entity3352 abolished this response. @entity3352 pretreatment did not prevent the p.d. from increasing in response to theophylline. Changes in p.d. in response to @entity1426 were greatly attenuated, and the response to @entity2544 was abolished in seminal vesicle tissue taken from castrated @entity840 . Seminal vesicles, aorta and ileum taken from castrated @entity840 synthesized and released more @entity2918 than did those from control animals. It is concluded that the effects of @entity1426 on p.d. are mediated by its metabolism to @entity2918 ; the inability of seminal vesicles from castrated animals to respond to @entity1426 is not a result of a decrease in @entity3009 production, but is more likely a result of other degenerative changes attendant upon castration; and @entity3800 appear to have some regulatory function on @entity3009 synthesis in a variety of tissues.

title: Effect of castration on XXXX -mediated changes in membrane potential and @entity3009 synthesis in @entity840 seminal vesicle tissue.

entities_list: @entity2544 :: ('MESH:D013806', 'Chemical') :: ['theophylline']

entities_list: @entity840 :: ('10141', 'Species') :: ['guinea-pig', 'guinea-pigs']

entities_list: @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostaglandins']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['Arachidonic acid', 'arachidonic acid']

entities_list: @entity3009 :: ('CHEBI:26333', 'Chemical') :: ['prostaglandin']

entities_list: @entity3352 :: ('MESH:D007213', 'Chemical') :: ['Indomethacin', 'indomethacin']

entities_list: @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']

answer: @entity3009 :: (CHEBI:26333,Chemical) :: ['prostaglandin']


abstract: @entity1426 stimulated an increase in transmural electrical potential difference (p.d.) in @entity840 seminal vesicle tissue in vitro. Pretreatment with @entity3352 abolished this response. @entity3352 pretreatment did not prevent the p.d. from increasing in response to theophylline. Changes in p.d. in response to @entity1426 were greatly attenuated, and the response to @entity2544 was abolished in seminal vesicle tissue taken from castrated @entity840 . Seminal vesicles, aorta and ileum taken from castrated @entity840 synthesized and released more @entity2918 than did those from control animals. It is concluded that the effects of @entity1426 on p.d. are mediated by its metabolism to @entity2918 ; the inability of seminal vesicles from castrated animals to respond to @entity1426 is not a result of a decrease in @entity3009 production, but is more likely a result of other degenerative changes attendant upon castration; and @entity3800 appear to have some regulatory function on @entity3009 synthesis in a variety of tissues.

title: Effect of castration on @entity3009 -mediated changes in membrane potential and XXXX synthesis in @entity840 seminal vesicle tissue.

answer: @entity3009 :: (CHEBI:26333,Chemical) :: ['prostaglandin']


abstract: @entity1426 stimulated an increase in transmural electrical potential difference (p.d.) in @entity840 seminal vesicle tissue in vitro. Pretreatment with @entity3352 abolished this response. @entity3352 pretreatment did not prevent the p.d. from increasing in response to theophylline. Changes in p.d. in response to @entity1426 were greatly attenuated, and the response to @entity2544 was abolished in seminal vesicle tissue taken from castrated @entity840 . Seminal vesicles, aorta and ileum taken from castrated @entity840 synthesized and released more @entity2918 than did those from control animals. It is concluded that the effects of @entity1426 on p.d. are mediated by its metabolism to @entity2918 ; the inability of seminal vesicles from castrated animals to respond to @entity1426 is not a result of a decrease in @entity3009 production, but is more likely a result of other degenerative changes attendant upon castration; and @entity3800 appear to have some regulatory function on @entity3009 synthesis in a variety of tissues.

title: Effect of castration on @entity3009 -mediated changes in membrane potential and @entity3009 synthesis in XXXX seminal vesicle tissue.

answer: @entity840 :: (10141,Species) :: ['guinea-pig']


abstract: PURPOSE: To evaluate the therapeutic efficacy and safety of supplemental transcatheter arterial chemoembolization (TACE) through the extrahepatic @entity432 ( @entity432 ) for the treatment of @entity157 ( @entity157 ). METHODS: We studied 21 @entity1 with extrahepatic collaterals of the @entity432 , among 1,512 @entity1 with @entity157 who had undergone angiography. HCCs supplied by collateral OAs were located at: segment IV in seven, segment V in five, segment III in three, segment VI in three and segment @entity797 in three @entity1 (Couinaud classification of segments). On preoperative CT scans, every @entity157 was abutting the liver surface. @entity2617 or engorgement was noted in 11 @entity1 . @entity99 showed @entity1184 of the feeding @entity432 in all @entity1 . TACE of the @entity432 was performed in 19 @entity1 with an emulsion of iodized oil and @entity632 . Embolization with gelatin sponge particles was added in five @entity1 . RESULTS: Collaterals of the @entity432 to the @entity157 were found on the first to seventeenth sessions of TACE. On follow-up CT scans, five @entity1 showed complete uptake of iodized oil in the @entity5 . Partial uptake of iodized oil was noted in 13 @entity1 and no uptake in one @entity1 . There was no serious complication that related to the omental embolization, such as @entity63 . The cumulative survival rates from the time of the TACE of the @entity432 were 81% at 6 months and 68% at 12 months. CONCLUSION: TACE of the @entity432 is safe and has a potential therapeutic effect in the treatment of @entity157 .

title: XXXX through a @entity432 : treatment for @entity157 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin hydrochloride']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['omental or bowel ischemia']

entities_list: @entity2617 :: ('MESH:D017254', 'Disease') :: ['Adjacent omental infiltration']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['OA', 'collateral omental artery']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['Celiac and hepatic arteriograms']

answer: @entity432 :: (MESH:D001157,Disease) :: ['Supplemental transcatheter arterial chemoembolization']


abstract: PURPOSE: To evaluate the therapeutic efficacy and safety of supplemental transcatheter arterial chemoembolization (TACE) through the extrahepatic @entity432 ( @entity432 ) for the treatment of @entity157 ( @entity157 ). METHODS: We studied 21 @entity1 with extrahepatic collaterals of the @entity432 , among 1,512 @entity1 with @entity157 who had undergone angiography. HCCs supplied by collateral OAs were located at: segment IV in seven, segment V in five, segment III in three, segment VI in three and segment @entity797 in three @entity1 (Couinaud classification of segments). On preoperative CT scans, every @entity157 was abutting the liver surface. @entity2617 or engorgement was noted in 11 @entity1 . @entity99 showed @entity1184 of the feeding @entity432 in all @entity1 . TACE of the @entity432 was performed in 19 @entity1 with an emulsion of iodized oil and @entity632 . Embolization with gelatin sponge particles was added in five @entity1 . RESULTS: Collaterals of the @entity432 to the @entity157 were found on the first to seventeenth sessions of TACE. On follow-up CT scans, five @entity1 showed complete uptake of iodized oil in the @entity5 . Partial uptake of iodized oil was noted in 13 @entity1 and no uptake in one @entity1 . There was no serious complication that related to the omental embolization, such as @entity63 . The cumulative survival rates from the time of the TACE of the @entity432 were 81% at 6 months and 68% at 12 months. CONCLUSION: TACE of the @entity432 is safe and has a potential therapeutic effect in the treatment of @entity157 .

title: @entity432 through a XXXX : treatment for @entity157 .

answer: @entity432 :: (MESH:D001157,Disease) :: ['collateral omental artery']


abstract: PURPOSE: To evaluate the therapeutic efficacy and safety of supplemental transcatheter arterial chemoembolization (TACE) through the extrahepatic @entity432 ( @entity432 ) for the treatment of @entity157 ( @entity157 ). METHODS: We studied 21 @entity1 with extrahepatic collaterals of the @entity432 , among 1,512 @entity1 with @entity157 who had undergone angiography. HCCs supplied by collateral OAs were located at: segment IV in seven, segment V in five, segment III in three, segment VI in three and segment @entity797 in three @entity1 (Couinaud classification of segments). On preoperative CT scans, every @entity157 was abutting the liver surface. @entity2617 or engorgement was noted in 11 @entity1 . @entity99 showed @entity1184 of the feeding @entity432 in all @entity1 . TACE of the @entity432 was performed in 19 @entity1 with an emulsion of iodized oil and @entity632 . Embolization with gelatin sponge particles was added in five @entity1 . RESULTS: Collaterals of the @entity432 to the @entity157 were found on the first to seventeenth sessions of TACE. On follow-up CT scans, five @entity1 showed complete uptake of iodized oil in the @entity5 . Partial uptake of iodized oil was noted in 13 @entity1 and no uptake in one @entity1 . There was no serious complication that related to the omental embolization, such as @entity63 . The cumulative survival rates from the time of the TACE of the @entity432 were 81% at 6 months and 68% at 12 months. CONCLUSION: TACE of the @entity432 is safe and has a potential therapeutic effect in the treatment of @entity157 .

title: @entity432 through a @entity432 : treatment for XXXX .

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: OBJECTIVE: To evaluate of the efficacy and safety of 8 hours of continuous, low-level heatwrap therapy administered during sleep. DESIGN: Prospective, randomized, parallel, single-blind (investigator), placebo-controlled, multicenter clinical trial. SETTING: Two community-based research facilities. @entity1 : Seventy-six @entity1 , aged 18 to 55 years, with acute, nonspecific @entity1643 . INTERVENTIONS: Subjects were stratified by baseline @entity158 intensity and gender and randomized to one of the following treatments: evaluation of efficacy (heatwrap, n=33; oral placebo, n=34) or blinding (unheated wrap, n=5; oral @entity5018 , n=4). All treatments were administered for 3 consecutive nights with 2 days of follow-up. MAIN OUTCOME MEASURES: Primary: morning @entity158 relief (hour 0) on days 2 through 4 (0-5-point verbal response scale). Secondary: mean @entity158 relief score (days 2-4, hours 0-8), mean extended @entity158 relief score (day 4, hour 0; day 5, hour 0), @entity121 , lateral trunk flexibility, and disability (Roland-Morris Disability Questionnaire). RESULTS: Heatwrap therapy was significantly better than placebo at hour 0 on days 2 through 4 for mean @entity158 relief (P=.00005); at hours 0 through 8 on days 2 through 4 for @entity158 relief (P<.001); at hour 0 on day 4 and at hour 0 on day 5 for mean @entity158 relief (P<.001); on day 4 in reduction of morning @entity121 (P<.001); for increased lateral trunk flexibility on day 4 (P<.002); and for @entity1643 on day 4 (P=.005). Adverse events were mild and infrequent. CONCLUSIONS: Overnight use of heatwrap therapy provided effective @entity158 relief throughout the next day, reduced @entity121 and disability, and improved trunk flexibility. Positive effects were sustained more than 48 hours after treatments were completed.

title: Overnight use of continuous low-level heatwrap therapy for relief of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['decreased low back disability', 'low back pain']

entities_list: @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['daytime pain', 'pain']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle stiffness']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['low back pain']


abstract: OBJECTIVE: To determine whether computer adaptive testing (CAT) can be used to decrease the number of @entity15467 trade mark instrument motor component items administered in assessing @entity1 with @entity1566 ( @entity1566 ). DESIGN: For a CAT simulation, a 3-step algorithm was used to select 6 @entity15467 items for each individual; items were selected according to the subject's motor ability as estimated by 2 initial items. Separate estimates of motor ability for admission, discharge, and follow-up data (plus combined time points) derived from 6 items were compared statistically with estimates derived from 14 items (walking and wheelchair mobility were split). SETTING: Records from the @entity1566 ( @entity1566 ). @entity1 : @entity1 served by the @entity1566 , for whom complete motor @entity15467 information was available for rehabilitation admission (N=5,969), discharge (N=5,964), or follow-up at a first or later anniversary (N=5,176). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Similarity of mean, standard deviation, @entity1319 , kurtosis, and Rasch reliability and separation of @entity1 and items based on 6 and 13 items; intraclass correlation coefficient (ICC) for parallel estimates. RESULTS: Calibrations for @entity15467 items and @entity15467 steps differed for the 3 time points, but showed sufficient agreement (ICC, >.90) that combined calibration was feasible. Means and other distribution characteristics differed minimally between the 6- and 13-item estimates. The @entity1 and item separations and reliabilities were somewhat lower and the mean measurement errors somewhat higher for the 6-item estimates, but only marginally so. ICCs between 6- and 13-item estimates were .95 or higher. CONCLUSION: CAT can be used to reduce data collection time; the level of precision of estimates is minimally less than that provided by traditional assessment approaches.

title: A computer adaptive testing simulation applied to the XXXX instrument motor component.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'person', 'PARTICIPANTS', 'persons']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCIMS', 'SCI', 'Spinal Cord Injury Model Systems']

answer: @entity15467 :: (MESH:C535759,Disease) :: ['FIM']


abstract: The specificity of three commonly used monoclonal antibodies (MoAbs) reacting with @entity1 class II histocompatibility antigens, was analyzed to determine whether these MoAbs would distinguish between @entity3099 , DQ, and DR in a large number of haplotypes. The reactivity of these MoAbs (L243, Anti-Leu 10, and @entity72435 ) was compared by serial immunoprecipitation of class II antigens from 11 B-cell lines. The cell lines examined expressed a total of five DP, three DQ, and nine DR types, which together represent most of the well-defined class II specificities. This is the first demonstration that one of these antibodies, @entity72435 . binds to at least five DP specificities, and does not bind to DR or DQ molecules as defined by reactivity with the two other MoAbs. Within the scope of these experiments, the @entity72435 antibody was shown to react with a monomorphic DP determinant. A variant clone of the @entity72435 hybridoma was isolated that secretes IgG1 antibody with the same specificity as the original @entity3172 antibody. The two other antibodies studied have been previously shown to react with DR molecules (L243) or DQ molecules (Anti-Leu 10). Here, their lack of cross-reaction with DP molecules is demonstrated. Thus, each of the three MoAbs reacts exclusively with a distinct class II molecule in all haplotypes studied, and therefore should be useful for comparing the independent expression and function of DP, DQ, and DR molecules.

title: Monoclonal antibodies that distinguish between class II antigens ( XXXX , DQ, and DR) in 14 haplotypes.

answer: @entity3099 :: (3115,Gene) :: ['HLA-DP']


abstract: The classification scheme of @entity401 has undergone numerous revisions. The criteria for distinguishing seven distinct subtypes of @entity16058 are now well defined by consensus in the recently published ATS/ERS classification of these @entity358 . In our present review the histological patterns of the different types are described and the differential diagnosis of @entity16058 is discussed. Surgical lung biopsy remains the gold standard for the diagnosis of @entity401 , and sampling from at least 2 sites is recommended. Video-assisted thoracoscopic surgical biopsy is the preferred method for obtaining lung tissue as this procedure offers a similar yield as an open thoracotomy The most common histological subtype of chronic @entity401 is the @entity2416 [ @entity2416 ] which makes up 47-71% of cases. The key histologic features include patchy subpleural and paraseptal distribution of remodeling lung architecture with dense @entity82 , frequent honeycombing, and large fibroblastic foci. Temporal and spatial heterogeneity are the hallmarks. @entity401 [ @entity401 ] occurs primarily in middle-aged @entity1 who have never smoked, with more than 5-years survival rate in 80% of @entity1 . The major feature of @entity401 is a uniform interstitial thickening of @entity133 by a fibrosing or cellular process. The cardinal histological feature in @entity1576 and desquamative @entity55 is an excess of intraalveolar histiocytes. In both patterns, there is variable interstitial @entity82 and @entity32 , and a strong association with a history of smoking. @entity3616 ( @entity3616 [BOOP]) is not strictly an interstitial process, because the alveoli and bronchioles are filled by intraluminal polyps of fibroblastic tissue and the expansion of the interstitium is mild. @entity401 [ @entity401 ] is currently viewed as a pattern of diffuse reactive @entity358 associated in most cases with EB virus, immunosuppression, or a @entity2597 . Malignant transformation may rarely occur. A dense mixed interstitial lymphoid infiltrate is a typical histological finding. @entity16 [ @entity16 ] from unknown causes is termed @entity401 [ @entity401 ], and is synonymous with cases of @entity2416 . Hyaline membranes in the exsudative phase and marked expansion of the interstitium later are present.

title: [Histopathological classification of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation']

entities_list: @entity2597 :: ('MESH:D003240', 'Disease') :: ['connective tissue disorder']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity16058 :: ('MESH:D054988', 'Disease') :: ['idiopathic interstitial pneumonias']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['Diffuse alveolar damage', 'DAD']

entities_list: @entity3616 :: ('MESH:D018549', 'Disease') :: ['Organizing pneumonia', 'idiopathic bronchiolitis obliterans-organizing pneumonia']

entities_list: @entity133 :: ('MESH:D002282', 'Disease') :: ['alveolar septa']

entities_list: @entity2416 :: ('MESH:D054990', 'Disease') :: ['UIP', 'Hamman-Rich disease', 'usual interstitial pneumonia']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['lung diseases', 'pulmonary hyperplasia']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory bronchiolitis']

entities_list: @entity401 :: ('MESH:D017563', 'Disease') :: ['interstitial pneumonias', 'interstitial lung diseases', 'interstitial lung disease', 'Lymphocytic interstitial pneumonia', 'Nonspecific interstitial pneumonia', 'NSIP', 'acute interstitial pneumonia', 'AIP', 'LIP']

answer: @entity16058 :: (MESH:D054988,Disease) :: ['idiopathic interstitial pneumonias']


abstract: PURPOSE: To determine the effectiveness of a novel stannous-containing @entity3163 dentifrice in reducing malodor-causing volatile @entity599 compound (VSC) levels versus a standard marketed fluoride (negative control) anti-caries dentifrice using pooled data from independent clinical trials. METHODS: Four randomized and controlled, evaluator-blinded, 3- or 4-period, 2-treatment crossover clinical studies were conducted at four separate centers in Asia and the United States in subjects with a baseline VSC score of > 100 ppb. Following a week-long acclimation period, subjects were randomly assigned to a treatment sequence specifying the order of use of a stannous-containing @entity3163 dentifrice and a negative control dentifrice (Crest Cavity Protection). VSC levels were assessed at four time points using a Halimeter during each treatment period: (1) baseline prior to treatment; (2) 3-4 hours after baseline and a single brushing; (3) 24 hours post-baseline and after two total brushings ("overnight"/" @entity1353 "); and (4) 27-28 hours post-baseline following three total product uses. Brushing instructions were standardized and required two minutes of timed toothbrushing with the assigned dentifrice. Washout periods of at least 2 days separated the treatment periods. RESULTS: A total of 100 subjects were included in the meta-analysis. The stannous-containing dentifrice showed statistically significantly greater breath benefits via VSC reduction compared to the negative control dentifrice (P < 0.047) at all three time points. The stannous-containing dentifrice provided increasingly greater superior relative breath protection benefits of 7.7% at Hour 3-4 post-baseline, 10.6% after 24 hours ("overnight"/" @entity1353 "), and 24.5% at Hour 27-28. Similar malodor reduction benefits in favor of the stannous-containing dentifrice relative to the negative control were observed for each individual study.

title: Breath malodor reduction with use of a stannous-containing XXXX dentifrice: a meta-analysis of four randomized and controlled clinical trials.

entities_list: @entity3163 :: ('MESH:D012969', 'Chemical') :: ['sodium fluoride']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['morning breath']

answer: @entity3163 :: (MESH:D012969,Chemical) :: ['sodium fluoride']