abstract: The ability to predict protein function from structure is becoming increasingly important; hence, elucidation and determination of protein structure become the major steps in proteomics. The present study was undertaken for identification of metalloprotease produced by @entity5259 B80 and recognition of characteristics that can be industrially exploited. The enzyme was purified in three steps combining precipitation and chromatographic methods resulting in 33.5% recovery with 13.1-fold purification of enzyme which was detected as a single band with a molecular mass of 26   kDa approximately in @entity214 -PAGE and zymogram. The @entity215 showed that the enzyme exhibited 70-93% similarity with @entity219 metalloproteases from various strains Bacillus sp. specifically from @entity5259 group. The sequence alignment revealed the presence of @entity219 -binding region VVVHEMCHMV in the most conserved C terminus region. Secondary structure of the enzyme was obtained by CD spectra and I-TASSER. The enzyme kinetics revealed a Michaelis constant (K m ) of 0.140    mol/ml and V max of 2.11    mol/min. The application studies showed that the enzyme was able to hydrolyze various proteins with highest affinity towards casein followed by BSA and gelatin. The enzyme exhibited strong fibrinolytic, collagenolytic, and gelatinolytic properties and stability in various organic solvents.

title: @entity215 and CD Spectral Analysis for Identification and Structure Prediction of a Purified, Novel, Organic Solvent Stable, Fibrinolytic Metalloprotease from XXXX B80.

answer: @entity5259 :: (1396,Species) :: ['Bacillus cereus']


abstract: @entity6368 is an important @entity2953 ( @entity2953 ) causing pathogen worldwide. Due to absence of an affordable diagnostic assay, routine screening of @entity2954 becomes impossible in developing countries where @entity281 rates are maximum. Treatment is given on the basis of symptoms alone which leads to spread of @entity281 . Thus, development of a rapid, sensitive, specific, and PCR based visual diagnostic assay suitable for developing countries, required for better disease management, is aimed at in present study. Endocervical swabs were collected from @entity1 visiting gynecology department of various hospitals in Delhi. In-house PCR based assay was developed and modified to visual assay using molecular beacon for end-point detection. It was evaluated against Roche AMPLICOR NG kit and rmp gene. Specificity of beacon was confirmed by competition experiments. Diagnostic test was 98.21% specific and 99.59% sensitive whereas negative and positive predicted value were 99.40% and 98.78%, respectively. We also observed that twice the concentration (2X) of premix was stable at 4  C for 4 months and dry swab samples gave concordant results with that of wet swabs. These features make the test best suitable for routine diagnosis of @entity281 in developing countries.

title: Diagnosis of XXXX Using Molecular Beacon.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2954 :: ('MESH:D006069', 'Disease') :: ['gonococcal infection']

entities_list: @entity6368 :: ('485', 'Species') :: ['Neisseria gonorrhoeae']

entities_list: @entity2953 :: ('MESH:D012749', 'Disease') :: ['STD', 'sexually transmitted diseases']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'genital infections']

answer: @entity6368 :: (485,Species) :: ['Neisseria gonorrhoeae']


abstract: OBJECTIVE: In this study, we aimed to investigate the association of @entity25731 polymorphism of the b3-adrenergic receptor gene (b-3AR) with childhood @entity28 and related pathologies. METHODS: b-3AR gene @entity25731 genotyping was carried out in 251 @entity1 aged 6-18 years. Of these subjects, 130 were @entity28 (62 @entity1 ) and 121 were normal-weight (53 @entity1 ). In the @entity28 group, fasting lipids, @entity413 and @entity2690 levels were measured. Oral @entity413 tolerance test (OGTT) was performed in 75 of the @entity28 @entity1 . RESULTS: The frequency of @entity25731 genotype was similar in @entity28 and @entity28 @entity1 . In @entity28 @entity1 , relative body mass index, waist-to-hip ratio, serum lipid, @entity413 and @entity2690 levels, as well as homeostasis model assessment of @entity2690 resistance (HOMA-IR) scores were not different between @entity534 allele carriers ( @entity25731 and @entity71288 ) and noncarriers ( @entity71289 ). In 75 @entity28 @entity1 , OGTT results showed that @entity534 allele carriers had significantly higher 30-minute @entity413 levels (p=0.027). CONCLUSION: @entity25731 polymorphism of the b-3AR gene is not associated with @entity28 and waist-to-hip ratio in Turkish @entity1 . Although there were no relationships between the genotypes and lipid, @entity413 / @entity2690 levels or HOMA-IR, the presence of @entity25731 variant seemed to have an unfavorable influence on early @entity413 excursion after @entity413 loading.

title: b-3AR @entity25731 Polymorphism and 30-Minute Post-Challenge Plasma @entity413 Levels in Obese XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'boys']

entities_list: @entity71289 :: ('p|SUB|W|64|W', 'ProteinMutation') :: ['W64W']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['non-obese', 'obese', 'obesity']

entities_list: @entity25731 :: ('p|SUB|W|64|R', 'ProteinMutation') :: ['W64R']

entities_list: @entity71288 :: ('p|SUB|R|64|R', 'ProteinMutation') :: ['R64R']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: OBJECTIVE: In this study, we aimed to investigate the association of @entity25731 polymorphism of the b3-adrenergic receptor gene (b-3AR) with childhood @entity28 and related pathologies. METHODS: b-3AR gene @entity25731 genotyping was carried out in 251 @entity1 aged 6-18 years. Of these subjects, 130 were @entity28 (62 @entity1 ) and 121 were normal-weight (53 @entity1 ). In the @entity28 group, fasting lipids, @entity413 and @entity2690 levels were measured. Oral @entity413 tolerance test (OGTT) was performed in 75 of the @entity28 @entity1 . RESULTS: The frequency of @entity25731 genotype was similar in @entity28 and @entity28 @entity1 . In @entity28 @entity1 , relative body mass index, waist-to-hip ratio, serum lipid, @entity413 and @entity2690 levels, as well as homeostasis model assessment of @entity2690 resistance (HOMA-IR) scores were not different between @entity534 allele carriers ( @entity25731 and @entity71288 ) and noncarriers ( @entity71289 ). In 75 @entity28 @entity1 , OGTT results showed that @entity534 allele carriers had significantly higher 30-minute @entity413 levels (p=0.027). CONCLUSION: @entity25731 polymorphism of the b-3AR gene is not associated with @entity28 and waist-to-hip ratio in Turkish @entity1 . Although there were no relationships between the genotypes and lipid, @entity413 / @entity2690 levels or HOMA-IR, the presence of @entity25731 variant seemed to have an unfavorable influence on early @entity413 excursion after @entity413 loading.

title: b-3AR @entity25731 Polymorphism and 30-Minute Post-Challenge Plasma XXXX Levels in Obese @entity1 .

answer: @entity413 :: (MESH:D005947,Chemical) :: ['Glucose']


abstract: OBJECTIVE: In this study, we aimed to investigate the association of @entity25731 polymorphism of the b3-adrenergic receptor gene (b-3AR) with childhood @entity28 and related pathologies. METHODS: b-3AR gene @entity25731 genotyping was carried out in 251 @entity1 aged 6-18 years. Of these subjects, 130 were @entity28 (62 @entity1 ) and 121 were normal-weight (53 @entity1 ). In the @entity28 group, fasting lipids, @entity413 and @entity2690 levels were measured. Oral @entity413 tolerance test (OGTT) was performed in 75 of the @entity28 @entity1 . RESULTS: The frequency of @entity25731 genotype was similar in @entity28 and @entity28 @entity1 . In @entity28 @entity1 , relative body mass index, waist-to-hip ratio, serum lipid, @entity413 and @entity2690 levels, as well as homeostasis model assessment of @entity2690 resistance (HOMA-IR) scores were not different between @entity534 allele carriers ( @entity25731 and @entity71288 ) and noncarriers ( @entity71289 ). In 75 @entity28 @entity1 , OGTT results showed that @entity534 allele carriers had significantly higher 30-minute @entity413 levels (p=0.027). CONCLUSION: @entity25731 polymorphism of the b-3AR gene is not associated with @entity28 and waist-to-hip ratio in Turkish @entity1 . Although there were no relationships between the genotypes and lipid, @entity413 / @entity2690 levels or HOMA-IR, the presence of @entity25731 variant seemed to have an unfavorable influence on early @entity413 excursion after @entity413 loading.

title: b-3AR XXXX Polymorphism and 30-Minute Post-Challenge Plasma @entity413 Levels in Obese @entity1 .

answer: @entity25731 :: (p|SUB|W|64|R,ProteinMutation) :: ['W64R']


abstract: BACKGROUND: Time spent sitting is distinctly different from accumulating too little physical activity and may have independent deleterious effects. Few studies have examined the association between sitting time and site-specific @entity5 incidence. METHODS: Among 69,260 @entity1 and 77,462 @entity1 who were @entity5 -free and enrolled in the American @entity5 Society @entity5 Prevention Study II Nutrition Cohort, 18,555 @entity1 and 12,236 @entity1 were diagnosed with @entity5 between 1992 and 2009. Extended Cox proportional hazards regression was used to estimate multivariable-adjusted relative risks (RR) and 95% confidence intervals (CI) of leisure-time spent sitting with total and site-specific @entity5 incidence. RESULTS: Longer leisure-time spent sitting, after adjustment for physical activity, BMI, and other factors, was associated with risk of total @entity5 in @entity1 (RR = 1.10; 95% CI, 1.04-1.17 for >= 6 hours vs. <3 hours per day), but not @entity1 (RR = 1.00; 95% CI, 0.96-1.05). In @entity1 , sitting time was associated with risk of @entity1582 (RR = 1.65; 95% CI, 1.07-2.54), invasive @entity0 (RR = 1.10; 95% CI, 1.00-1.21), and @entity43 (RR = 1.43; 95% CI, 1.10-1.87). There were no associations between sitting time and site-specific @entity5 in @entity1 . CONCLUSION: Longer leisure-time spent sitting was associated with a higher risk of total @entity5 risk in @entity1 , and specifically with @entity1582 , @entity5344 , but sitting time was not associated with @entity5 risk in @entity1 . Further research is warranted to better understand the differences in associations between @entity1 and @entity1 . IMPACT: For @entity1 , these findings support American @entity5 Society guidelines for @entity5 prevention to reduce sitting time when possible.

title: Leisure-Time Spent Sitting and Site-Specific XXXX Incidence in a Large U.S. Cohort.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5344 :: ('MESH:D061325', 'Disease') :: ['breast, and ovarian cancers']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cancer']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: BACKGROUND: According to some studies, @entity1897 healing is prolonged in elderly @entity1 . @entity7577 in the elbow (UNE) is the second most common @entity2850 . To our knowledge, no study has investigated the effect of age on the postoperative @entity3165 repair rate. Our aim was to evaluate age-related differences in the electrophysiological parameters before and approximately 100  days after operations for @entity7769 . METHODS: This retrospective study included 103 @entity1 who underwent in situ ulnar nerve decompressions in the elbow. The included @entity1 suffered from paraesthesia and @entity1183 in their ulnar nerve distribution, @entity1184 , and weakening of the hand muscles, which were innervated by the ulnar nerve. Concurrently, these @entity1 met the EGM diagnostic criteria for UNE. The age dependency on the differences between the preoperative and postoperative parameter values that were measured during the conductive studies was estimated using a regression analysis. RESULTS: A statistically significant deceleration of the monitored parameter adaptation, which included segmental conduction velocity in the elbow area and @entity13432 amplitude during the above-elbow stimulation of the ulnar nerve, was found. CONCLUSIONS: @entity3165 repair in the cubital tunnel area after a UNE operation proceeds significantly slower in elderly @entity1 .

title: The dependence of age on ulnar nerve conductive study parameter adaptation after XXXX operations in the elbow.

entities_list: @entity3165 :: ('MESH:D020424', 'Disease') :: ['ulnar nerve injury', 'Ulnar nerve injury']

entities_list: @entity1183 :: ('MESH:D006987', 'Disease') :: ['hypoesthesia']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity7769 :: ('MESH:D020430', 'Disease') :: ['cubital tunnel syndrome']

entities_list: @entity2850 :: ('MESH:D009408', 'Disease') :: ['compressive mononeuropathy']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral nerve injury']

entities_list: @entity7577 :: ('MESH:C536965', 'Disease') :: ['Compressive ulnar neuropathy']

answer: @entity7577 :: (MESH:C536965,Disease) :: ['compressive ulnar neuropathy']


abstract: The aim of this research was the study of efficiency and endurance antihypertensive therapy on the basis of fixed combination of @entity4688 and @entity918 ( @entity918 ) and @entity4688 and @entity918 in combination with @entity3591 according to the twenty-four-hour (? day-and-night) monitoring of blood pressure (? 24H BPM) of @entity1 with @entity101 ( @entity101 ) 2-3 severity. The study included 33 @entity1 with 2-3 grade of @entity101 (average age--54,40    3.45 years). All @entity1 performed ? 24H BPM before treatment and after 12 weeks of therapy. The combination of @entity4688 and @entity918 allowed to achieve target levels of blood pressure in 79% of @entity1 , @entity3591 additional purpose--in 86% of @entity1 . We found that this therapy has a corrective effect on daily blood pressure profile, significantly reducing the load pressure and blood pressure variability. During treatment with the combination of @entity4688 and @entity918 combination of @entity4688 , @entity918 with @entity3591 optimal daily profile of blood pressure after 12 weeks of reaching respectively 63.1% and 71.4% of @entity1 . The treatment with combination of @entity4688 and @entity918 and adding of @entity3591 is characterized by good endurance and high adherence to treatment.

title: [Changes of twenty-four-hour profile blood pressure anad its correction of @entity1 with XXXX on the background of combined antihypertensive therapy application].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'arterial hypertension', 'AH']

entities_list: @entity918 :: ('MESH:D006852', 'Chemical') :: ['HCTZ', 'hydrochlorothiazide']

entities_list: @entity3591 :: ('MESH:D017311', 'Chemical') :: ['amlodipine']

answer: @entity101 :: (MESH:D006973,Disease) :: ['arterial hypertension']


abstract: The aim of this research was the study of efficiency and endurance antihypertensive therapy on the basis of fixed combination of @entity4688 and @entity918 ( @entity918 ) and @entity4688 and @entity918 in combination with @entity3591 according to the twenty-four-hour (? day-and-night) monitoring of blood pressure (? 24H BPM) of @entity1 with @entity101 ( @entity101 ) 2-3 severity. The study included 33 @entity1 with 2-3 grade of @entity101 (average age--54,40    3.45 years). All @entity1 performed ? 24H BPM before treatment and after 12 weeks of therapy. The combination of @entity4688 and @entity918 allowed to achieve target levels of blood pressure in 79% of @entity1 , @entity3591 additional purpose--in 86% of @entity1 . We found that this therapy has a corrective effect on daily blood pressure profile, significantly reducing the load pressure and blood pressure variability. During treatment with the combination of @entity4688 and @entity918 combination of @entity4688 , @entity918 with @entity3591 optimal daily profile of blood pressure after 12 weeks of reaching respectively 63.1% and 71.4% of @entity1 . The treatment with combination of @entity4688 and @entity918 and adding of @entity3591 is characterized by good endurance and high adherence to treatment.

title: [Changes of twenty-four-hour profile blood pressure anad its correction of XXXX with @entity101 on the background of combined antihypertensive therapy application].

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: ParB proteins bind centromere-like DNA sequences called parS sites and are involved in plasmid and chromosome segregation in bacteria. We previously showed that the opportunistic @entity1 pathogen @entity328 contains four parS sequences located close to the origin of replication which are bound by ParB. Using chromatin immunoprecipitation (ChIP), we found here that ParB spreads out from one of these parS sites, parS(-1.6  ), for more than 5  kb and occupies the nearby comCDE operon, which drives competence development. Competence allows @entity2260 to take up DNA from its environment, thereby mediating horizontal gene transfer, and is also employed as a general stress response. Mutating parS(-1.6  ) or deleting parB resulted in transcriptional up-regulation of comCDE and ssbB (a gene belonging to the competence regulon), demonstrating that ParB acts as a repressor of competence. However, genome-wide transcription analysis showed that ParB is not a global transcriptional regulator. Different factors, such as the composition of the growth medium and antibiotic-induced stress, can trigger the sensitive switch driving competence. This work shows that the ParB-parS chromosome segregation machinery also influences this developmental process. IMPORTANCE: @entity328 (pneumococcus) is an important @entity1 pathogen responsible for more than a million deaths each year. Like all other organisms, @entity2260 must be able to segregate its chromosomes properly. Not only is understanding the molecular mechanisms underlying chromosome segregation in @entity2260 therefore of fundamental importance, but also, this knowledge might offer new leads for ways to target this pathogen. Here, we identified a link between the pneumococcal chromosome segregation system and the competence-developmental system. Competence allows @entity2260 to take up and integrate exogenous DNA in its chromosome. This process plays a crucial role in successful adaptation to-and escape from-host defenses, antibiotic treatments, and vaccination strategies. We show that the chromosome segregation protein ParB acts as a repressor of competence. To the best of our knowledge, this is the first example of a ParB protein controlling bacterial competence.

title: The ParB-parS Chromosome Segregation System Modulates Competence Development in XXXX .

entities_list: @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']

answer: @entity328 :: (1313,Species) :: ['Streptococcus pneumoniae']


abstract: A @entity1 , now 28 years old, was diagnosed 6 years ago as chronic @entity631 by renal biopsy. From August 15, 1975 she complained of @entity390 , @entity1277 and weight (about 7 kg within 2 weeks). Severe @entity101 (200/130 mmHg), @entity2753 (123 mEq/liter), @entity417 , elevated plasma @entity916 activity (PRA), advanced @entity2629 , and eye ground changes of KW-II were found. Dialysis treatment was started on September 2, 1975. From November 1975 massive amounts of @entity1372 (5,000 mEq or more monthly) and water (26 liters or more monthly) were removed by the dialysis. These intensive dialyses resulted in an elevated PRA with recurrence of severe @entity101 . At the end of March 1976 she became almost blind with @entity989 of KW-IV. Potent @entity551 drugs including beta-blockers were administered, but no improvements were obtained. On March 31, 1976 nephrectomy was performed to save her life. Marked hyalinization of glomeruli and heavy thickening of intima in interlobular arteries were found in the removed kidneys. @entity2791 was not recognized either macroscopically or histologically. In this @entity1 , the amount of @entity1372 removed by the dialysis was dependent on her diastolic blood pressure and @entity1372 concentration of the dialysis. It may be concluded that too enthusiastic dialysis may develop @entity101 due to excessive @entity916 release.

title: Development of XXXX in @entity1 with uremia under hemodialysis: a case report and discussions on its etiology.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'malignant hypertension']

entities_list: @entity2791 :: ('MESH:D012078', 'Disease') :: ['Renal artery stenosis']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

entities_list: @entity1277 :: ('MESH:D001068', 'Disease') :: ['loss of appetite']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

entities_list: @entity2753 :: ('MESH:D007010', 'Disease') :: ['hyponatremia']

answer: @entity101 :: (MESH:D006973,Disease) :: ['malignant hypertension']


abstract: A @entity1 , now 28 years old, was diagnosed 6 years ago as chronic @entity631 by renal biopsy. From August 15, 1975 she complained of @entity390 , @entity1277 and weight (about 7 kg within 2 weeks). Severe @entity101 (200/130 mmHg), @entity2753 (123 mEq/liter), @entity417 , elevated plasma @entity916 activity (PRA), advanced @entity2629 , and eye ground changes of KW-II were found. Dialysis treatment was started on September 2, 1975. From November 1975 massive amounts of @entity1372 (5,000 mEq or more monthly) and water (26 liters or more monthly) were removed by the dialysis. These intensive dialyses resulted in an elevated PRA with recurrence of severe @entity101 . At the end of March 1976 she became almost blind with @entity989 of KW-IV. Potent @entity551 drugs including beta-blockers were administered, but no improvements were obtained. On March 31, 1976 nephrectomy was performed to save her life. Marked hyalinization of glomeruli and heavy thickening of intima in interlobular arteries were found in the removed kidneys. @entity2791 was not recognized either macroscopically or histologically. In this @entity1 , the amount of @entity1372 removed by the dialysis was dependent on her diastolic blood pressure and @entity1372 concentration of the dialysis. It may be concluded that too enthusiastic dialysis may develop @entity101 due to excessive @entity916 release.

title: Development of @entity101 in XXXX with uremia under hemodialysis: a case report and discussions on its etiology.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Histoplasmosis is a progressive disease caused by dimorphic intracellular fungi and can prove fatal. Usually, it is present in immunocompromised individuals and immunocompetent individuals in the endemic zones. We report an unusual presentation of progressive disseminated @entity3219 . The @entity1 in the present case report was immunocompetent @entity1 and had @entity221 , @entity158 , gradual weight loss, @entity3329 and @entity828 . @entity3219 ( @entity3219 ) was diagnosed on microscopic examination and fungal culture of bone marrow, blood, skin biopsy and lymph node aspirate. The @entity1 died on seventh day of @entity2379 . In the absence of predisposing factors and classical clinical presentation of @entity1398 , lung, adrenal and oropharyngeal lesions, the disease posed a diagnostic challenge. Progressive disseminated @entity3219 in @entity1 can be fatal despite timely diagnosis and therapy. In India, disseminated @entity3219 is seen in immunocompetent hosts. All the pediatrics immunocompetent cases from India are also reviewed.

title: An Unusual Presentation of Disseminated Histoplasmosis: Case Report and Review of Pediatric Immunocompetent XXXX from India.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patient', 'child']

entities_list: @entity3329 :: ('MESH:D008206', 'Disease') :: ['lymphadenopathy']

entities_list: @entity2379 :: ('MESH:D000666', 'Chemical') :: ['amphotericin B']

entities_list: @entity828 :: ('MESH:C535727', 'Disease') :: ['hepatosplenomegaly']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['febrile neutropenia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['bone pains']

entities_list: @entity3219 :: ('MESH:D006660', 'Disease') :: ['histoplasmosis', 'Disseminated histoplasmosis', 'DH']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: Cardiometabolic risk factors and related @entity65 represent major threats to healthy aging. OBJECTIVE: We aimed to estimate distribution, pharmacological treatment, and control of main cardiometabolic risk factors among older @entity1 . METHODS: This population-based study included 3363 @entity1 (age>= 60 years, 64.9% @entity1 ) in the Swedish National study on Aging and Care in Kungsholmen, in central Stockholm, Sweden (2001-2004). Data on demographics, cardiometabolic risk factors ( @entity101 , @entity28 , @entity6 , and high cholesterol), and medication use were collected through face-to-face interviews, clinical examinations, laboratory tests, and the inpatient register. Cardiometabolic risk factors were defined following the most commonly used criteria. Prevalence was standardized using local census data. RESULTS: The age- and sex-standardized prevalence of @entity6 , @entity28 , high cholesterol, and @entity101 was 9.5%, 12.8%, 49.7%, and 74.9%, respectively. The prevalence of @entity101 and @entity6 increased with age, whereas the prevalence of @entity28 and high cholesterol decreased with age. Forty-nine percent of older adults had two or more cardiometabolic risk factors; 9.8% had three or more. Overall, 55.5% of @entity1 with @entity101 , 50.3% with @entity6 , and 25.0% with high cholesterol received pharmacological treatment. Of those treated pharmacologically, 49.4%, 38.1%, and 85.5% reached therapeutic goals for @entity101 (blood pressure<150/90 mmHg), @entity6 (glycated haemoglobin<7%), and high cholesterol (total cholesterol<6.22 mmol/l), respectively. CONCLUSIONS: @entity101 , high cholesterol, and clustering of cardiometabolic risk factors were common among older @entity1 in Stockholm, but pharmacological treatment and control of these major factors can be improved. Appropriate management of cardiometabolic profiles among older @entity1 may help improve @entity65 and achieve healthy aging.

title: Prevalence, Pharmacological Treatment, and Control of Cardiometabolic Risk Factors among Older XXXX in Central Stockholm: A Population-Based Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'people']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'Hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular health', 'cardiovascular diseases']

answer: @entity1 :: (9606,Species) :: ['People']


abstract: One case of a very rare @entity54146 of ovarium origin was observed and establishment of its cell lines from the fluid obtained by paracentitis was accomplished. This report is on the determination of the @entity5 and the biological characteristics of its cultured cells. ( @entity5 ) (1) This @entity5 was diagnosed as a malignant of the right ovary, using bimanual examination, selective angiography of the uterine artery, ultrasonic tomography, and abdominal ascitic cell examination. (2) The morphological type of @entity5 was based findings of @entity1710 eosin. @entity575 , Mallory and @entity8530 hematoxylin stainings. The @entity5 was diagnosed as an @entity43 and probably myogenic. However, a clear cross strain could not be demonstrated. (Cell biological characteristics) (1) Morphological characteristics of cultured cells: a) Phase-contrast microscopy and Papanicolaou staining revealed round or short and spindle shaped cells, with markedly enlarged nucleoli. These proliferated without exhibiting any tendency of contact inhibition. Also frequently recognized were giant cells, multinuclear cells, an some bizarre such as a starfish-shaped cell. b) Electron microscopy revealed that bundles of fibrils regarded as myofibrils existed in the cytoplasma, with dense patches within them, but a cross strain could not be demonstrated. (2) Morphological characteristics of the @entity5 cells grown in a nude @entity19 : a) The @entity5 cells demonstrated similarities to the original tissues by of H.E., @entity575 , and Mallary stainings. b) A number of fibrils recognized by the electron microscopic observation were 100 A in width and were arranged in a concentric circles. In addition to the light microscopic findings, the above findings indicated that this cell line originated from @entity242 . (3) Biological characteristics of the cultured cells: a) The number of chromosomes varied widely and spread aneuploidically, the highest chromosome number was 76. b) Doubling time, Saturation density, and plating efficiency was 31.2 hr, 1.2 x 10(5)/cm2 and 43.9% respectively. c) These cells had a high sensitivity for trypsin and started morphological change rapidly.

title: [Human XXXX and its cell culture (author's transl)].

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian sarcoma']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['myogenic sarcoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Determination of the tumor']

entities_list: @entity8530 :: ('MESH:D010772', 'Chemical') :: ['phosphotungstic acid']

entities_list: @entity54146 :: ('MESH:D009217', 'Disease') :: ['myosarcoma']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian myosarcoma']


abstract: BACKGROUND: The rich neovascularization of @entity8 ( @entity359 ) has a tendency for @entity1409 with subsequent @entity548 . Nephrectomy or nephron-sparing surgery has rarely been used as a primary treatment in urgent situations. PURPOSE: To evaluate the safety and long-term outcomes for @entity1 treated by urgent transcatheter @entity1416 (TAE) for spontaneous @entity8 with severe @entity548 . MATERIAL AND METHODS: A retrospective evaluation was performed of 25 renal @entity359 cases with spontaneous @entity548 confirmed by imaging. @entity4832 ( @entity939 ) particles and coils of multiple sizes were used to embolize the spontaneous @entity8 . RESULTS: The technical success rate of TAE was 96% (24/25). One week post-TAE, 1 @entity1 with recurrent @entity548 underwent emergency nephrectomy. @entity532 affected 16 @entity1 with @entity887 ; 15 @entity1 resolved using conservative measures and one @entity1 received nephrectomy post TAE 1 week later. All @entity1 were followed up for 24-72 months (median, 50.2 months). Surgical treatment was avoided for 92% (23/25) of @entity1 , and the re-embolization rate was 0% at 2 years post TAE. In the 23 @entity1 without surgical treatment, the mean maximum diameter of renal @entity359 was reduced from 12.4        5.5   cm to 6.3        2.5   cm and no @entity548 occurred during follow-up. CONCLUSION: Urgent TAE is a technically feasible and minimally invasive procedure for controlling severe @entity548 and preservation of renal function following spontaneous @entity8 .

title: Urgent transcatheter @entity1416 for the treatment of XXXX with spontaneous @entity548 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal AML ruptures', 'ruptured renal AML', 'renal angiomyolipoma']

entities_list: @entity4832 :: ('MESH:D011142', 'Chemical') :: ['Polyvinyl alcohol']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity1409 :: ('MESH:D012422', 'Disease') :: ['spontaneous rupture']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolization']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['Minor complications']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['post-embolization syndrome']

answer: @entity8 :: (MESH:D007674,Disease) :: ['ruptured renal angiomyolipoma']


abstract: BACKGROUND: The rich neovascularization of @entity8 ( @entity359 ) has a tendency for @entity1409 with subsequent @entity548 . Nephrectomy or nephron-sparing surgery has rarely been used as a primary treatment in urgent situations. PURPOSE: To evaluate the safety and long-term outcomes for @entity1 treated by urgent transcatheter @entity1416 (TAE) for spontaneous @entity8 with severe @entity548 . MATERIAL AND METHODS: A retrospective evaluation was performed of 25 renal @entity359 cases with spontaneous @entity548 confirmed by imaging. @entity4832 ( @entity939 ) particles and coils of multiple sizes were used to embolize the spontaneous @entity8 . RESULTS: The technical success rate of TAE was 96% (24/25). One week post-TAE, 1 @entity1 with recurrent @entity548 underwent emergency nephrectomy. @entity532 affected 16 @entity1 with @entity887 ; 15 @entity1 resolved using conservative measures and one @entity1 received nephrectomy post TAE 1 week later. All @entity1 were followed up for 24-72 months (median, 50.2 months). Surgical treatment was avoided for 92% (23/25) of @entity1 , and the re-embolization rate was 0% at 2 years post TAE. In the 23 @entity1 without surgical treatment, the mean maximum diameter of renal @entity359 was reduced from 12.4        5.5   cm to 6.3        2.5   cm and no @entity548 occurred during follow-up. CONCLUSION: Urgent TAE is a technically feasible and minimally invasive procedure for controlling severe @entity548 and preservation of renal function following spontaneous @entity8 .

title: Urgent transcatheter XXXX for the treatment of @entity8 with spontaneous @entity548 .

answer: @entity1416 :: (MESH:D020762,Disease) :: ['arterial embolization']


abstract: BACKGROUND: The rich neovascularization of @entity8 ( @entity359 ) has a tendency for @entity1409 with subsequent @entity548 . Nephrectomy or nephron-sparing surgery has rarely been used as a primary treatment in urgent situations. PURPOSE: To evaluate the safety and long-term outcomes for @entity1 treated by urgent transcatheter @entity1416 (TAE) for spontaneous @entity8 with severe @entity548 . MATERIAL AND METHODS: A retrospective evaluation was performed of 25 renal @entity359 cases with spontaneous @entity548 confirmed by imaging. @entity4832 ( @entity939 ) particles and coils of multiple sizes were used to embolize the spontaneous @entity8 . RESULTS: The technical success rate of TAE was 96% (24/25). One week post-TAE, 1 @entity1 with recurrent @entity548 underwent emergency nephrectomy. @entity532 affected 16 @entity1 with @entity887 ; 15 @entity1 resolved using conservative measures and one @entity1 received nephrectomy post TAE 1 week later. All @entity1 were followed up for 24-72 months (median, 50.2 months). Surgical treatment was avoided for 92% (23/25) of @entity1 , and the re-embolization rate was 0% at 2 years post TAE. In the 23 @entity1 without surgical treatment, the mean maximum diameter of renal @entity359 was reduced from 12.4        5.5   cm to 6.3        2.5   cm and no @entity548 occurred during follow-up. CONCLUSION: Urgent TAE is a technically feasible and minimally invasive procedure for controlling severe @entity548 and preservation of renal function following spontaneous @entity8 .

title: Urgent transcatheter @entity1416 for the treatment of @entity8 with spontaneous XXXX .

answer: @entity548 :: (MESH:D006470,Disease) :: ['hemorrhage']


abstract: PURPOSE: To evaluate the risk factors, recurrence rates, retreatments, and long-term @entity1 outcomes following proton beam therapy for @entity2184 . DESIGN: Retrospective interventional case series. METHODS: All @entity1 treated with primary proton beam therapy for @entity2184 at the oncology service at Charit  -Berlin and Helmholtz-Zentrum-Berlin between May 1998 and December 2008 were reviewed for local recurrence. Of 982 @entity1 , 982 eyes matched the inclusion criteria. The data were obtained from electronic health records, operative reports, discharge letters, and radiation planning. Comparisons of fundus photographs and ultrasound measurements were performed to assess the growth pattern of the tumor and to determine the success of retreatment, in the case that a globe-retaining therapy was undertaken. RESULTS: Of 982 @entity1 , 35 @entity1 (3.6%) developed local recurrence. The median follow-up was 60.7 months (6.0-170.4 months). Local control rate was 96.4% and the overall eye retention rate was 95.0% in this cohort. Local recurrence was correlated with a higher risk for metastasis and reduced survival. Largest tumor diameter was identified as the sole statistically significant risk factor for local recurrence (P = .00001). All globe-retaining retreatment approaches for local recurrence, including proton beam therapy, brachytherapy, and transpupillary thermotherapy used for recurrences at the tumor margins, showed good local tumor control and similar metastasis-free survivals. CONCLUSIONS: This study showed that each globe-retaining retreatment approach can result in satisfying local tumor control. In case of early detection of local recurrence, preservation of the globe can be warranted. Therefore, regularly performed follow-ups should be ensured.

title: Local Recurrence After Primary Proton Beam Therapy in XXXX : Risk Factors, Retreatment Approaches, and Outcome.

entities_list: @entity2184 :: ('MESH:C536494', 'Disease') :: ['uveal melanoma']

answer: @entity2184 :: (MESH:C536494,Disease) :: ['Uveal Melanoma']


abstract: BACKGROUND AND AIM OF THE STUDY: The study aim was to investigate the mid-term outcome of tricuspid annuloplasty (TAP) in the repair of functional @entity997 ( @entity997 ), using the three-dimensional (3D) @entity13684 ring with 'aggressive' stitches. METHODS: Between May 2007 and December 2012, a total of 165 @entity1 (104 @entity1 , 61 @entity1 ; mean age 68.0    9.0 years) underwent TAP using the @entity13684 ring. Horizontal mattress sutures were placed on the annulus beyond the anteroseptal commissure and away from the deemed atrioventricular node artery/vein, which could be detected in the triangle of Koch. Transthoracic echocardiography was performed preoperatively and postoperatively. The severity of @entity997 was graded from 0 to 4. The mean follow up was 30.3    20.4 months. RESULTS: Both, @entity997 grade and pulmonary artery systolic pressure (PASP) were significantly improved postoperatively. After a median of 24 months, the mean @entity997 grade and PASP remained satisfactory. The overall survival rates were 97.6% and 94.8% at one and four years, respectively. The rates of freedom from recurrent @entity997 (grade > 2) were 97.3% and 90.5% at one and four years, respectively. There were neither @entity9054 requiring new pacemaker implantation, nor reoperations for recurrent @entity997 . Multivariate analysis showed that recurrent @entity997 during the follow up period was significantly related to severe preoperative @entity997 . CONCLUSION: The clinical and echocardiographic results of TAP with the @entity13684 ring and 'aggressive' stitches were excellent, though further follow up is mandatory to confirm the safety and durability of this technique. Detection of the prominent vessel in the triangle of Koch can be helpful in avoiding @entity9054 after TAP.

title: Early and mid-term outcomes of aggressive tricuspid annuloplasty with the XXXX ring.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity997 :: ('MESH:D014262', 'Disease') :: ['TR', 'tricuspid regurgitation']

entities_list: @entity9054 :: ('MESH:D019955', 'Disease') :: ['impulse conduction disorders']

answer: @entity13684 :: (4159,Gene) :: ['MC3']


abstract: PURPOSE: Anterior shoulder dislocation can be associated with many lesions such as @entity75 , @entity717 ( @entity717 ), @entity1051 or greater tuberosity fractures. It has been documented that early management of the associated injury affords better recovery of shoulder function. The aim of this study was to highlight the incidence of associated injuries after @entity2065 . METHODS: A total of 240 @entity1 with @entity2065 were subjected to complete history taking, neurovascular assessment and pre-reduction plain X-ray. An X-ray was taken immediately after reduction. Ultrasonography (US) and magnetic resonance imaging (MRI) were done within one  week after reduction in all @entity1 . Nerve conduction studies were ordered for any @entity1 with suspected @entity128 . RESULTS: Associated lesions were reported in 144 (60  %) @entity1 . @entity717 was the most common injury (67 cases). It was isolated in 34 @entity1 (14.15  %), while it was combined with other lesions in 33 cases (13.75  %). @entity128 was encountered in 38 @entity1 , of them 8 (3.33  %) were isolated and 30 (12.5  %) were combined. Greater tuberosity @entity174 was found in 37 @entity1 , of them 15 (6.25  %) were combined with @entity128 , and in the other 22 @entity1 (9.17  %) the @entity174 was isolated. All cases with Hill-Sachs and @entity75 were combined lesions with no isolated cases. There was a significant relation between the incidence of associated injuries and age, mechanism of injury and the affected side. CONCLUSIONS: Lesions associated with @entity2065 are more frequent than expected. Thorough clinical examination and detailed imaging including US and MRI are mandatory to avoid a missed diagnosis.

title: Prevalence of associated injuries after XXXX : a prospective study.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Bankart lesion', 'Bankart lesions']

entities_list: @entity1051 :: ('MESH:D013661', 'Disease') :: ['Hill-Sachs lesions']

entities_list: @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury', 'axillary nerve injury', 'Axillary nerve injury']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['rotator cuff tears', 'RCT']

entities_list: @entity2065 :: ('MESH:D012783', 'Disease') :: ['anterior shoulder dislocation', 'traumatic anterior glenohumeral dislocations']

answer: @entity2065 :: (MESH:D012783,Disease) :: ['anterior shoulder dislocation']


abstract: Oesophageal lesion is the commonest visceral manifestation of @entity785 ( @entity785 ) affecting the quality of life and fraught with serious complications. The aim of this study was to evaluate clinical, endoscopic andmorphological manifestations of oesophageal lesion in @entity785 and its relationships with other clinical symptoms and pharmacotherapy of the disease. MATERIALS AND METHODS: 479 @entity1 with @entity785 (93.7% @entity1 , 6.3% @entity1 , mean age 48.7 +/- 19.2 yr). All of them underwent EGDS in 2005-2010. 123 @entity1 were examined for the detection of @entity355 ( @entity355 ), total screening regardless of complaints was conducted in 2010. Control group included 1018 age and sex-matched @entity1 with @entity309 who underwent EGDS in 2008-2009. RESULTS: Oesophageal lesions occurred much more frequently in @entity785 than in @entity309 . Oesophageal symptoms were documented in 70.0 and 29.9% cases, @entity2681 in 28.8 and 1.5%, @entity2910 in 22.5 and 2.2% @entity1066 in 0.8 and 0% (p < 0.001). @entity355 manifested as intestinal metaplasia (histological study of mucosal biopsy) was found in 30 @entity785 @entity1 (4.2%). Screening revealed @entity355 in 8.9% of the @entity1 . The development of @entity2681 was unrelated to the age of the @entity1 , duration of the disease and its form (localized or diffusive), lung pathology or @entity10632 . Cytotoxic medicines significantly increased the frequency of @entity2681 , it tended to increase under effect of NSAID and low doses of @entity117 . Long-term intake of PPI did not reduce the risk of @entity354 and @entity355 . CONCLUSION: Half of the @entity1 with @entity785 have @entity354 . Over 20% of them suffer its complications ( @entity2681 and @entity1066 ) and 9% have @entity355 . All such @entity1 need endoscopic study ofoesophagus regardless of clinical symptoms.

title: [Clinical, endoscopic and morphological manifestations of oesophageal lesion in XXXX ].

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's oesophagus", 'BO']

entities_list: @entity2681 :: ('MESH:D014077', 'Disease') :: ['erosion', 'non-erosive oesopahgitis', 'erosive oesophagitis']

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['erosive esophagitis']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['oesophagitis']

entities_list: @entity10632 :: ('MESH:D012859', 'Disease') :: ["Sjogren's syndrome"]

entities_list: @entity785 :: ('MESH:D012595', 'Disease') :: ['systemic scleroderma', 'SSD']

answer: @entity785 :: (MESH:D012595,Disease) :: ['systemic scleroderma']


abstract: PURPOSE: To develop a new @entity146 ( @entity146 ) scheme using a content-based image retrieval (CBIR) approach for classification between the malignant and benign @entity1558 depicted on the digital mammograms and assess @entity146 performance and reproducibility. METHODS: An image dataset including 820 regions of interest (ROIs) was used. Among them, 431 ROIs depict malignant lesions and 389 depict benign lesions. After applying an image preprocessing process to define the lesion center, two image features were computed from each ROI. The first feature is an average pixel value of a mapped region generated using a watershed algorithm. The second feature is an average pixel value difference between a ROI's center region and the rest of the image. A two-step CBIR approach uses these two features sequentially to search for ten most similar reference ROIs for each queried ROI. A similarity based classification score was then computed to predict the likelihood of the queried ROI depicting a @entity5 . To assess the reproducibility of the @entity146 scheme, we selected another independent testing dataset of 100 ROIs. For each ROI in the testing dataset, we added four randomly queried lesion center pixels and examined the variation of the classification scores. RESULTS: The area under the ROC curve (AUC) = 0.962    0.006 was obtained when applying a leave-one-out validation method to 820 ROIs. Using the independent testing dataset, the initial AUC value was 0.832    0.040, and using the median classification score of each ROI with five queried seeds, AUC value increased to 0.878    0.035. CONCLUSIONS: The authors demonstrated that (1) a simple and efficient CBIR scheme using two lesion density distribution related features achieved high performance in classifying @entity1558 without actual lesion segmentation and (2) similar to the conventional @entity146 schemes using global optimization approaches, improving reproducibility is also one of the challenges in developing @entity146 schemes using a CBIR based regional optimization approach.

title: Assessment of performance and reproducibility of applying a content-based image retrieval scheme for classification of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant lesion']

entities_list: @entity1558 :: ('MESH:D001941', 'Disease') :: ['breast lesions']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['computer-aided diagnosis', 'CAD']

answer: @entity1558 :: (MESH:D001941,Disease) :: ['breast lesions']


abstract: PURPOSE: To develop an automatic markerless 4D-CBCT projection sorting technique by using a @entity1 respiratory motion model extracted from the planning 4D-CT images. METHODS: Each phase of onboard 4D-CBCT is considered as a deformation of one phase of the prior planning 4D-CT. The deformation field map (DFM) is represented as a linear combination of three major deformation patterns extracted from the planning 4D-CT using principle component analysis (PCA). The coefficients of the PCA deformation patterns are solved by matching the digitally reconstructed radiograph (DRR) of the deformed volume to the onboard projection acquired. The PCA coefficients are solved for each single projection, and are used for phase sorting. Projections at the peaks of the Z direction coefficient are sorted as phase 1 and other projections are assigned into 10 phase bins by dividing phases equally between peaks. The 4D digital extended-cardiac-torso (XCAT) phantom was used to evaluate the proposed technique. Three scenarios were simulated, with different @entity5 motion amplitude (3cm to 2cm), @entity5 spatial shift (8mm SI), and @entity5 body motion phase shift (2 phases) from prior to on-board images. Projections were simulated over 180 degree scan-angle for the 4D-XCAT. The percentage of accurately binned projections across entire dataset was calculated to represent the phase sorting accuracy. RESULTS: With a changed @entity5 motion amplitude from 3cm to 2cm, markerless phase sorting accuracy was 100%. With a @entity5 phase shift of 2 phases w.r.t. body motion, the phase sorting accuracy was 100%. With a @entity5 spatial shift of 8mm in SI direction, phase sorting accuracy was 86.1%. CONCLUSION: The XCAT phantom simulation results demonstrated that it is feasible to use prior knowledge and motion modeling technique to achieve markerless 4D-CBCT phase sorting. National Institutes of Health Grant No. R01-CA184173 Varian Medical System.

title: SU-E-J-26: A Novel Technique for Markerless Self-Sorted 4D-CBCT Using XXXX Motion Modeling: A Feasibility Study.

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: PURPOSE: 4DCT has been widely used to generate internal @entity5 volume (ITV) for a @entity2 for treatment planning. However, @entity2 may show different respiratory motion on the treatment day. The purpose of this study is to evaluate 4D KV conebeam computed tomography (CBCT) for monitoring @entity5 interfractional motion variation between simulation and each fraction of stereotactic body radiation therapy (SBRT) for @entity2 . METHODS: 4D KV CBCT was acquired with the Elekta XVI system. The accuracy of 4D KV CBCT for image-guided radiation therapy (IGRT) was tested with a dynamic thorax motion phantom (CIRS, Virginia) with a linear amplitude of 2 cm. In addition, an adult anthropomorphic phantom (Alderson, Rando) with optically stimulated luminescence (OSL) dosimeters embedded at the center and periphery of a slab of solid water was used to measure the dose of 4D KV CBCT and to compare it with the dose with 3D KV CBCT. The image registration was performed by aligning\ each phase images of 4D KV CBCT to the planning images and the final couch shifts were calculated as a mean of all these individual shifts along each direction.A workflow was established based on these quality assurance tests for @entity2 @entity1 . RESULTS: 4D KV CBCT does not increase imaging dose in comparison to 3D KV CBCT. Acquisition of 4D KV CBCT is 4 minutes as compared to 2 minutes for 3D KV CBCT. Most of @entity1 showed a small daily variation of @entity5 respiratory motion about 2 mm. However, some @entity1 may have more than 5 mm variations of @entity5 respiratory motion. CONCLUSION: The radiation dose does not increase with 4D KV CBCT. 4D KV CBCT is a useful tool for monitoring interfractional variations of @entity5 respiratory motion before SBRT of @entity2 @entity1 .

title: SU-E-J-31: Monitor Interfractional Variation of Tumor Respiratory Motion Using 4D KV Conebeam Computed Tomography for Stereotactic Body Radiation Therapy of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung tumors', 'lung cancer', 'lung tumor']

answer: @entity2 :: (MESH:D008175,Disease) :: ['Lung Cancer']


abstract: BACKGROUND: In 2009 the American Society for Gastrointestinal Endoscopy (ASGE) guidelines advised that both @entity117 and NSAIDs be continued prior to low-risk gastrointestinal endoscopic procedures. We sought to determine physician knowledge regarding these guidelines. METHODS: A survey questionnaire was developed based on the ASGE guidelines. Physicians were queried about whether they would continue/stop @entity117 in a @entity1 with @entity299 and in a @entity1 taking NSAIDs for @entity625 whether they would continue/stop NSAIDs prior to endoscopy. The survey was administered at three academic medical centers. Demographic information: level of training, board certification, teaching trainees, percentage of time in clinical practice, year of medical school graduation, and location of medical school were all reviewed. The primary outcome was number of questions answered correctly and predictors of correct responses. RESULTS: The survey was administered to 941 @entity1 with 12 declining to participate, while 80  % (740/929) of the subjects completed the survey; 20  % (150/740) respondents answered both questions correctly and 42  % (310/740) answered one question correctly. There was no significant difference between institutions (p  =  0.6) or between attendings and trainees (p  =  0.75). Multivariate predictors of correct answers were self-reported familiarity with the guideline (-0.029; 95  % CI -0.003 to -0.056, p  <  0.031), level of training (0.050; 95  % CI 0.012-0.088, p  =  0.010), and specialty (0.108; 95  % CI 0.058-0.159, p  <  0.0001). Finally, there was an inverse, linear relationship between postgraduate year and percent questions correct. CONCLUSION: Physician knowledge of guidelines regarding the use of @entity117 and NSAIDs prior to endoscopy is suboptimal. Interventions are necessary to improve knowledge of the current pre-procedure guidelines.

title: Multicenter Study Assessing Physician Recommendations Regarding the Continuation of XXXX and/or NSAIDs Prior to Gastrointestinal Endoscopy.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patient']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease']

answer: @entity117 :: (MESH:D001241,Chemical) :: ['Aspirin']


abstract: OBJECTIVES: The aim of this study was to assess the impact of ticagrelor dosing regimens on pharmacodynamic (PD) profiles in @entity1 on maintenance ticagrelor therapy. BACKGROUND: Many @entity1 on maintenance @entity3075 -inhibiting therapies may require coronary revascularization procedures, raising a common clinical question with regard to the dosing regimen of the @entity3075 -inhibiting agent to be used. To date, investigations assessing dosing regimens of @entity3075 receptor inhibitors in @entity1 on maintenance therapy have been only assessed with @entity2405 , but not with ticagrelor. METHODS: This was a prospective, randomized, double-blind, placebo-controlled study assessing the PD effects of 2  dosing regimens of ticagrelor in @entity1 on standard @entity117 and ticagrelor maintenance therapy. A total of 60 @entity1 were randomized to either 90 mg ( @entity22 [ @entity22 ] group) or 180 mg (loading dose [LD] group) dose of ticagrelor. PD assessments were conducted at 3 time points (baseline, 1 h and 4 h). PD assessments were defined according to the platelet reactivity index (PRI) (vasodilator-stimulated phosphoprotein phosphorylation assay), @entity3075 reaction unit  (VerifyNow @entity3075 assay) and @entity857 -induced @entity1423 by light transmittance aggregometry. RESULTS: There were no differences in baseline levels of platelet reactivity with all assays. Intergroup comparisons by means of repeated-measures analysis adjusted for baseline PRI values showed that the LD group had significantly lower  PRI levels compared with the @entity22 group during the overall study time course (p  = 0.031). Consistent findings were  found for @entity3075 reaction unit (p  = 0.026) and light transmittance aggregometry (p  = 0.004). Intragroup comparisons showed that a more prompt and sustained platelet inhibitory effect was achieved more consistently with an LD regimen compared with a @entity22 regimen. CONCLUSIONS: In @entity1 on maintenance ticagrelor therapy, a 180-mg LD regimen of @entity3077 is associated with more potent and prompt platelet inhibition compared with a 90-mg @entity22 . (Impact of Ticagrelor Re-Load Pharmacodynamic Profiles; NCT01731041).

title: Pharmacodynamic Effects of Ticagrelor Dosing Regimens in XXXX on Maintenance Ticagrelor Therapy: Results From a Prospective, Randomized, Double-Blind Investigation.

entities_list: @entity2405 :: ('MESH:D058924', 'Chemical') :: ['thienopyridines']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity3077 :: ('MESH:C503700', 'Chemical') :: ['ticagrelor']

entities_list: @entity857 :: ('MESH:D000244', 'Chemical') :: ['adenosine diphosphate']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['maintenance dose', 'MD']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: Rituximab induces @entity1985 ( @entity1985 ) remission in two-thirds of @entity1 with primary @entity8 ( @entity8 ), even after other treatments have failed. To assess the relationships among treatment effect, circulating nephritogenic anti- @entity3900 receptor (anti- @entity8164 ) autoantibodies and genetic polymorphisms predisposing to antibody production we serially monitored 24-hour @entity644 and antibody titer in @entity1 with primary @entity8 and long-lasting @entity1985 consenting to rituximab (375 mg/m(2)) therapy and genetic analyses. Over a median (range) follow-up of 30.8 (6.0-145.4) months, 84 of 132 rituximab-treated @entity1 achieved complete or partial @entity1985 remission (primary end point), and 25 relapsed after remission. Outcomes of @entity1 with or without detectable anti- @entity8164 antibodies at baseline were similar. Among the 81 patients with antibodies, lower anti- @entity8164 antibody titer at baseline (P=0.001) and full antibody depletion 6 months post-rituximab (hazard ratio [HR], 7.90; 95% confidence interval [95% CI], 2.54 to 24.60; P<0.001) strongly predicted remission. All 25 complete remissions were preceded by complete anti- @entity8164 antibody depletion. On average, 50% anti- @entity8164 titer reduction preceded equivalent @entity644 reduction by 10 months. Re-emergence of circulating antibodies predicted disease relapse (HR, 6.54; 95% CI, 1.57 to 27.40; P=0.01), whereas initial complete remission protected from the event (HR, 6.63; 95% CI, 2.37 to 18.53; P<0.001). Eighteen @entity1 achieved persistent antibody depletion and complete remission and never relapsed. Outcome was independent of @entity8164 and @entity8167 polymorphisms and of previous immunosuppressive treatment. Therefore, assessing circulating anti- @entity8164 autoantibodies and @entity644 may help in monitoring disease activity and guiding personalized rituximab therapy in @entity1985 @entity1 with primary @entity8 .

title: Anti- @entity3900 Receptor Antibody Titer Predicts Post-Rituximab Outcome of XXXX .

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['membranous nephropathy', 'MN']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['NS', 'nephrotic', 'nephrotic syndrome']

answer: @entity8 :: (MESH:D007674,Disease) :: ['Membranous Nephropathy']


abstract: UNASSIGNED: Rituximab induces @entity1985 ( @entity1985 ) remission in two-thirds of @entity1 with primary @entity8 ( @entity8 ), even after other treatments have failed. To assess the relationships among treatment effect, circulating nephritogenic anti- @entity3900 receptor (anti- @entity8164 ) autoantibodies and genetic polymorphisms predisposing to antibody production we serially monitored 24-hour @entity644 and antibody titer in @entity1 with primary @entity8 and long-lasting @entity1985 consenting to rituximab (375 mg/m(2)) therapy and genetic analyses. Over a median (range) follow-up of 30.8 (6.0-145.4) months, 84 of 132 rituximab-treated @entity1 achieved complete or partial @entity1985 remission (primary end point), and 25 relapsed after remission. Outcomes of @entity1 with or without detectable anti- @entity8164 antibodies at baseline were similar. Among the 81 patients with antibodies, lower anti- @entity8164 antibody titer at baseline (P=0.001) and full antibody depletion 6 months post-rituximab (hazard ratio [HR], 7.90; 95% confidence interval [95% CI], 2.54 to 24.60; P<0.001) strongly predicted remission. All 25 complete remissions were preceded by complete anti- @entity8164 antibody depletion. On average, 50% anti- @entity8164 titer reduction preceded equivalent @entity644 reduction by 10 months. Re-emergence of circulating antibodies predicted disease relapse (HR, 6.54; 95% CI, 1.57 to 27.40; P=0.01), whereas initial complete remission protected from the event (HR, 6.63; 95% CI, 2.37 to 18.53; P<0.001). Eighteen @entity1 achieved persistent antibody depletion and complete remission and never relapsed. Outcome was independent of @entity8164 and @entity8167 polymorphisms and of previous immunosuppressive treatment. Therefore, assessing circulating anti- @entity8164 autoantibodies and @entity644 may help in monitoring disease activity and guiding personalized rituximab therapy in @entity1985 @entity1 with primary @entity8 .

title: Anti- XXXX Receptor Antibody Titer Predicts Post-Rituximab Outcome of @entity8 .

answer: @entity3900 :: (151056,Gene) :: ['Phospholipase A2']


abstract: BACKGROUND: Growing evidence suggests that the heart rate (HR) at rest is an independent predictor of @entity65 . In @entity385 , continuous monitoring of HR is the standard of care, but systematic data on its dynamics and prognostic value during the acute phase are limited. METHODS: In this prospective observational study, HR was measured by continuous electrocardiographic monitoring on admission and during the first 72  hours of care among @entity1 who were awake with @entity385 and survived until discharge. Functional outcome was assessed after 90  days. RESULTS: Data from 702 consecutive @entity1 were analyzed (median age, 73  years, 54% @entity1 ). The time course of HR was initially characterized by a rapid decline during the first 12  hours after admission. Among @entity1 who survived until day 90, this was followed by a continuous downward trend in HR, whereas @entity204 after discharge was associated with a secondary increase and a reversal point 12  hours after admission. After adjustment for established risk factors, this secondary increase during the acute period was an independent predictor of @entity204 (hazard ratio, 3.73; 95% confidence interval, 1.47-9.43; P  =  .005). CONCLUSIONS: A secondary rise of HR during care for acute @entity385 is an early  sign of fatality and may represent a surrogate for an unfavorable sympathetic disinhibition. Further research is warranted to clarify the role of targeted @entity299 after  @entity385 (http://clinicaltrials.gov/, unique identifier NCT01858779).

title: Impact of Heart Rate Dynamics on Mortality in the Early Phase after XXXX : A Prospective Observational Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['HR reduction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']


abstract: UNASSIGNED: The goal of this study was to attempt to determine the rate of contamination of health-care workers' (HCWs) hands and environmental surfaces in intensive care units (ICU) by the main bacteria associated with hospital acquired @entity281 (HAIs) in Tehran, Iran. A total of 605 and 762 swab samples were obtained from six ICU environments and HCWs' hands. Identification of the bacterial isolates was performed according to standard biochemical methods, and their antimicrobial susceptibility was determined based on the guidelines recommended by clinical and laboratory standards institute (CLSI). The homology of the resistance patterns was assessed by the NTSYSsp software. The most frequent bacteria on the HCWs' hands and in the environmental samples were @entity3064 (1.4% and 16.5%, respectively), @entity794 (5.9% and 8.1%, respectively), @entity5938 (20.9% and 18.7%, respectively), and Enterococcus spp. (1% and 1.3%, respectively). @entity1 ' @entity26 masks, ventilators, and bed linens were the most contaminated sites. Nurses' aides and housekeepers were the most contaminated staff. Imipenem resistant A. baumannii (94% and 54.5%), @entity3256 -resistant @entity794 (MRSAs, 59.6% and 67.3%), and @entity2176 resistant Enterococci (VREs, 0% and 25%) were detected on the hands of ICU staff and the environmental samples, respectively. Different isolates of @entity794 and Enterococcus spp. showed significant homology in these samples. These results showed contamination of the ICU environments and HCWs with important bacterial pathogens that are the main risk factors for HAIs in the studied hospitals.

title: The role of the intensive care unit environment and health-care workers in the transmission of bacteria associated with hospital acquired XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity3256 :: ('MESH:D008712', 'Chemical') :: ['methicillin']

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin']

entities_list: @entity5938 :: ('1282', 'Species') :: ['S. epidermidis']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity3064 :: ('470', 'Species') :: ['Acinetobacter baumannii']

answer: @entity281 :: (MESH:D007239,Disease) :: ['infections']


abstract: UNASSIGNED: @entity28219 ( @entity28219 ) is a rare soft tissue @entity5 of intermediate biologic potential and uncertain differentiation, most often arising in the extremities of @entity1 and young adults. Although it has characteristic histologic features of a lymphoid cuff surrounding nodules of ovoid cells with blood-filled cystic cavities, diagnosis is often difficult due to its morphologic heterogeneity and lack of specific immunoprofile. @entity28219 is associated with recurrent chromosomal translocations, leading to characteristic @entity12726 - @entity10366 , @entity12726 - @entity12569 , and, rarely, @entity28218 gene fusions; fluorescence in situ hybridization (FISH), detecting @entity12726 or @entity19957 rearrangements, and reverse transcription-polymerase chain reaction (RT-PCR) for @entity12726 - @entity10366 and @entity12726 - @entity12569 fusion transcripts have become routine ancillary tools. We present a large comparative series of FISH and RT-PCR for @entity28219 . Seventeen @entity5 (from 16 @entity1 ) histologically diagnosed as @entity28219 were assessed for @entity12726 rearrangements or @entity12726 - @entity10366 and @entity12726 - @entity12569 fusion transcripts. All 17 were positive for either FISH or RT-PCR or both. Of 16, 14 (87.5%) had detectable @entity12726 - @entity10366 or @entity12726 - @entity12569 fusion transcripts by RT-PCR, whereas 13 (76.5%) of 17 had positive @entity12726 rearrangement with FISH. All 13 of 13 non- @entity28219 control @entity5 failed to show @entity12726 - @entity10366 or @entity12726 - @entity12569 fusion transcripts, whereas @entity12726 rearrangement was present in 2 of these 13 cases (which were @entity5 ). This study shows that @entity12726 - @entity10366 or @entity12726 - @entity12569 fusions predominate in @entity28219 (supporting previous reports that @entity19957 rearrangement is rare in @entity28219 ) and that RT-PCR has a comparable detection rate to FISH for @entity28219 . Importantly, cases of @entity28219 can be missed if RT-PCR is not performed in conjunction with FISH, and RT-PCR has the added advantage of specificity, which is crucial, as @entity12726 rearrangements are present in a variety of @entity5 in the histologic differential diagnosis of @entity28219 , that differ in behavior and treatment.

title: XXXX : comparison of fluorescence in situ hybridization and reverse transcription polymerase chain reaction as adjunct diagnostic modalities.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['histopathologically myoepithelial neoplasms', 'neoplasm', 'neoplasms']

entities_list: @entity28219 :: ('MESH:C563181', 'Disease') :: ['AFH', 'Angiomatoid fibrous histiocytoma']

answer: @entity28219 :: (MESH:C563181,Disease) :: ['Angiomatoid fibrous histiocytoma']


abstract: UNASSIGNED: Suppressive myeloid cells represent a significant barrier to the generation of productive antitumor immune responses to many solid @entity5 . Eliminating or reprogramming suppressive myeloid cells to abrogate @entity5 -associated immune suppression is a promising therapeutic approach. We asked whether treatment of @entity146 disseminated @entity788 with the immunotherapeutic attenuated @entity3204 vaccine strain CPS would trigger @entity5 -associated myeloid cells to generate therapeutic antitumor immune responses. CPS treatment significantly decreased @entity5 -associated macrophages and markedly increased @entity788 microenvironment. Tumor-resident macrophages and dendritic cells, particularly cells actively invaded by CPS, increased expression of costimulatory molecules CD80 and CD86 and concomitantly boosted their production of IL12. CPS treatment increased CD4(+) and CD8(+) T-cell infiltration into the @entity5 microenvironment, activated @entity5 -resident T cells, and increased IFNy production by T-cell populations. CPS treatment provided a significant therapeutic benefit in @entity788 -bearing @entity19 . This therapeutic benefit depended on IL12 and IFNy production, MyD88 signaling, and CD8(+) T-cell populations. Although CD4(+) T cells exhibited activated effector phenotypes and produced IFNy, CD4(+) T cells as well as natural killer cells were not required for the therapeutic benefit. In addition, CD8(+) T cells isolated from CPS-treated @entity5 -bearing @entity19 produced IFNy after re-exposure to @entity788 antigen, suggesting this immunotherapeutic treatment stimulated @entity5 cell antigen-specific CD8(+) T-cell responses. This work highlights the potency and immunotherapeutic efficacy of CPS treatment and demonstrates the significance of targeting @entity5 -associated myeloid cells as a mechanism to stimulate more effective immunity to @entity788 . Cancer Immunol Res; 3(8); 1-11.   2015 AACR.

title: Attenuated @entity3204 Stimulates Immunity to XXXX by Manipulation of Myeloid Cell Populations.

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'dendritic cell infiltration of the pancreatic tumor', 'pancreatic tumor']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['established aggressive']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity3204 :: ('5811', 'Species') :: ['Toxoplasma gondii']

answer: @entity788 :: (MESH:D010190,Disease) :: ['Pancreatic Cancer']


abstract: UNASSIGNED: Suppressive myeloid cells represent a significant barrier to the generation of productive antitumor immune responses to many solid @entity5 . Eliminating or reprogramming suppressive myeloid cells to abrogate @entity5 -associated immune suppression is a promising therapeutic approach. We asked whether treatment of @entity146 disseminated @entity788 with the immunotherapeutic attenuated @entity3204 vaccine strain CPS would trigger @entity5 -associated myeloid cells to generate therapeutic antitumor immune responses. CPS treatment significantly decreased @entity5 -associated macrophages and markedly increased @entity788 microenvironment. Tumor-resident macrophages and dendritic cells, particularly cells actively invaded by CPS, increased expression of costimulatory molecules CD80 and CD86 and concomitantly boosted their production of IL12. CPS treatment increased CD4(+) and CD8(+) T-cell infiltration into the @entity5 microenvironment, activated @entity5 -resident T cells, and increased IFNy production by T-cell populations. CPS treatment provided a significant therapeutic benefit in @entity788 -bearing @entity19 . This therapeutic benefit depended on IL12 and IFNy production, MyD88 signaling, and CD8(+) T-cell populations. Although CD4(+) T cells exhibited activated effector phenotypes and produced IFNy, CD4(+) T cells as well as natural killer cells were not required for the therapeutic benefit. In addition, CD8(+) T cells isolated from CPS-treated @entity5 -bearing @entity19 produced IFNy after re-exposure to @entity788 antigen, suggesting this immunotherapeutic treatment stimulated @entity5 cell antigen-specific CD8(+) T-cell responses. This work highlights the potency and immunotherapeutic efficacy of CPS treatment and demonstrates the significance of targeting @entity5 -associated myeloid cells as a mechanism to stimulate more effective immunity to @entity788 . Cancer Immunol Res; 3(8); 1-11.   2015 AACR.

title: Attenuated XXXX Stimulates Immunity to @entity788 by Manipulation of Myeloid Cell Populations.

answer: @entity3204 :: (5811,Species) :: ['Toxoplasma gondii']


abstract: UNASSIGNED: Evaluation of stem cell-derived cardiomyocytes (SC-CM) using @entity9689 ( @entity9689 ) has attracted attention as a novel model to detect drug-induced @entity943 . An experiment was conducted to determine if @entity9689 recording from @entity1 induced pluripotent SC-CM (hiPSC-CM) could assess proarrhythmic risk. Ten @entity9493 blockers, 4 @entity4024 blockers, and 1 IKs blocker were evaluated blindly. Eight drugs are associated with @entity1166 ( @entity1166 ) and four are not. Multiple parameters, including field potential duration (FPD), @entity4024 slope, @entity4024 amplitude, beat rate (BR), and early after-depolarization (EAD) were recorded. @entity6251 ( @entity6251 ) that elicited a significant change were calculated. Our results determined that FPD and EAD were unable to distinguish torsadogenic from benign compounds, @entity4024 slope and amplitude could not differentiate @entity4024 channel blockade from @entity9493 blockade, BR had an inconsistent response to pharmacological treatment, and that hiPSC-CM were, in general, insensitive to IKs inhibition. A ratio was calculated that relates @entity6251 for evoking FPD prolongation, or triggering EAD, to the @entity1 therapeutic unbound Cmax ( @entity6251 /Cmax). The key finding was that the ratio was sensitive, but specificity was low. Consistently, the ratio had high positive predictive value and low negative predictive value. In conclusion, @entity9689 recordings of hiPSC-CM were sensitive for FPD and EAD detection, but unable to distinguish agents with low- and high-risk for TdPs. While some published reports suggested great potential for @entity9689 recordings in hSC-CM to assess preclinical @entity1370 , the current evaluation implies that this model would have a high false positive rate in regard to proarrhythmic risk.

title: Proarrhythmia Risk Assessment in @entity1 Induced Pluripotent Stem Cell-Derived Cardiomyocytes using the Maestro XXXX Platform.

entities_list: @entity1166 :: ('MESH:D016171', 'Disease') :: ['TdP', 'Torsades de Pointes']

entities_list: @entity9689 :: ('MESH:C564969', 'Disease') :: ['MEA', 'multi-electrode Array']

entities_list: @entity6251 :: ('MESH:C567712', 'Disease') :: ['Minimum effective concentrations', 'MEC']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiac toxicity']

answer: @entity9689 :: (MESH:C564969,Disease) :: ['MEA']


abstract: UNASSIGNED: Evaluation of stem cell-derived cardiomyocytes (SC-CM) using @entity9689 ( @entity9689 ) has attracted attention as a novel model to detect drug-induced @entity943 . An experiment was conducted to determine if @entity9689 recording from @entity1 induced pluripotent SC-CM (hiPSC-CM) could assess proarrhythmic risk. Ten @entity9493 blockers, 4 @entity4024 blockers, and 1 IKs blocker were evaluated blindly. Eight drugs are associated with @entity1166 ( @entity1166 ) and four are not. Multiple parameters, including field potential duration (FPD), @entity4024 slope, @entity4024 amplitude, beat rate (BR), and early after-depolarization (EAD) were recorded. @entity6251 ( @entity6251 ) that elicited a significant change were calculated. Our results determined that FPD and EAD were unable to distinguish torsadogenic from benign compounds, @entity4024 slope and amplitude could not differentiate @entity4024 channel blockade from @entity9493 blockade, BR had an inconsistent response to pharmacological treatment, and that hiPSC-CM were, in general, insensitive to IKs inhibition. A ratio was calculated that relates @entity6251 for evoking FPD prolongation, or triggering EAD, to the @entity1 therapeutic unbound Cmax ( @entity6251 /Cmax). The key finding was that the ratio was sensitive, but specificity was low. Consistently, the ratio had high positive predictive value and low negative predictive value. In conclusion, @entity9689 recordings of hiPSC-CM were sensitive for FPD and EAD detection, but unable to distinguish agents with low- and high-risk for TdPs. While some published reports suggested great potential for @entity9689 recordings in hSC-CM to assess preclinical @entity1370 , the current evaluation implies that this model would have a high false positive rate in regard to proarrhythmic risk.

title: Proarrhythmia Risk Assessment in XXXX Induced Pluripotent Stem Cell-Derived Cardiomyocytes using the Maestro @entity9689 Platform.

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: PURPOSE: The purpose of this study was to examine the effect of @entity6 self-management education (DSME) provided in a large urban @entity341 ( @entity341 ) by a certified @entity6 educator using a "learner-centered" approach to teaching survival skills. It was hypothesized that an intervention providing learner-centered education in the @entity341 would significantly improve @entity6 knowledge and self-management skills. METHODS: @entity1 were @entity1 who presented to the @entity341 with uncontrolled blood @entity413 with @entity6 ( @entity6 ). A learner-centered DSME approach was developed. Baseline knowledge and skills were assessed in the @entity341 with a 5-question test and a request to demonstrate meter and insulin injection technique. Education focused on identified gaps in knowledge and skills and incorporated an opportunity for the @entity1 to exercise control in the treatment process. At outpatient follow-up, knowledge retention was assessed with the same 5-question test, and skills again were tested. RESULTS: @entity1 with @entity6 who were provided learner-centered DSME in the @entity341 demonstrated a significant increase in knowledge-related test scores on all questions at follow-up. Significantly fewer @entity1 required meter and insulin injection instruction postintervention, compared to the baseline. CONCLUSION: Study results provide evidence supporting the effectiveness of learner-centered DSME delivered in the @entity341 at imparting critical knowledge and skills to @entity1 with @entity6 .

title: Successful @entity1 XXXX Education in the Emergency Department.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Participants']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'T2DM', 'type 2 diabetes mellitus']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: PURPOSE: The purpose of this study was to examine the effect of @entity6 self-management education (DSME) provided in a large urban @entity341 ( @entity341 ) by a certified @entity6 educator using a "learner-centered" approach to teaching survival skills. It was hypothesized that an intervention providing learner-centered education in the @entity341 would significantly improve @entity6 knowledge and self-management skills. METHODS: @entity1 were @entity1 who presented to the @entity341 with uncontrolled blood @entity413 with @entity6 ( @entity6 ). A learner-centered DSME approach was developed. Baseline knowledge and skills were assessed in the @entity341 with a 5-question test and a request to demonstrate meter and insulin injection technique. Education focused on identified gaps in knowledge and skills and incorporated an opportunity for the @entity1 to exercise control in the treatment process. At outpatient follow-up, knowledge retention was assessed with the same 5-question test, and skills again were tested. RESULTS: @entity1 with @entity6 who were provided learner-centered DSME in the @entity341 demonstrated a significant increase in knowledge-related test scores on all questions at follow-up. Significantly fewer @entity1 required meter and insulin injection instruction postintervention, compared to the baseline. CONCLUSION: Study results provide evidence supporting the effectiveness of learner-centered DSME delivered in the @entity341 at imparting critical knowledge and skills to @entity1 with @entity6 .

title: Successful XXXX @entity6 Education in the Emergency Department.

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: This population based cross-sectional study was conducted on 8283 @entity1 of all ages in five districts, selected conveniently, to assess the magnitude of @entity4858 , their causes and consequences in rural Bangladesh. Six Upazilas from five districts and from each Upazila one Union was selected randomly. One village, the ultimate cluster, was then selected conveniently from each Union. All @entity1 (n = 8283) in the 8 villages were then surveyed. Out of 8283 population (ranging from 1-120 years) surveyed, 167(2%) had history and/or evidence of past @entity2194 with a yearly incidence of 6.2 per 1000 per year. Study demonstrated a female predominance with male to female ratio being roughly 4:5. Majority (82%) had at least one episode of @entity130 in their life-time with mean age at 1st @entity130 being 20 years. Nearly 40% of the @entity130 were caused by blunt objects followed by penetrating object (22.3%) and sharp instrument (18.1%) with home being the primary place of occurrence (55.1%). Evidence of @entity2194 was found on eye-lid (15%), conjunctiva (11.4%) and @entity267 (10.2%) as scars. The older @entity1 (>=  30 years), females, illiterates, agriculture labors, housewives and household workers were more likely to receive @entity130 . Majority (86.8%) of the subjects received treatment following injury. The median time lapsed between injuries and receiving first treatment was 5 days and that between injury and visiting an eye-specialist was 18 days. Self-treatment and treatment from over-the-counter comprised 45% and 42.1% respectively followed by eye-specialists (25.5%), village quack (22.8%), graduate doctors (19.3%) and traditional healers (6.9%). About 87% received conservative management, with 12.4% needing hospitalization. Most of the injured (92.8%) and non-injured (95.2%) eyes had normal vision before @entity130 as informed by the respondents. Following @entity130 , 18% had impaired, 10.7% severely @entity227 and about 6% were blind. Job abstinence due to @entity130 was 53% with median wage loss being 10 days. The study concludes that point-prevalence of @entity2194 in rural area is around 2% with blunt objects commonly causing the @entity130 and one in every 16 @entity130 -hit case undergo blind. @entity1939 from @entity2194 , should, therefore, be a priority for eye care programs in rural Bangladesh.

title: XXXX : Prevalence in different rural population of Bangladesh.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'people', 'persons']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular trauma']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['impaired vision']

entities_list: @entity4858 :: ('MESH:D005131', 'Disease') :: ['ocular injuries']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['Addressing blindness']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumas', 'trauma']

answer: @entity4858 :: (MESH:D005131,Disease) :: ['Ocular injury']


abstract: This survey was conducted on 1000 physicians with @entity158 management responsibilities practicing in 47 districts in Bangladesh. The response rate was 58.3%. The physicians had a mean of 21 years in practice. It was notable that 66% of the physicians had seen @entity5 @entity1 in the last 12 months and 63% had seen @entity1 with advanced stage @entity5 where @entity4784 are considered as the mainstay of treatment. It was discouraging that 85% of the physicians preferred to prescribe @entity6882 , when @entity1 needed @entity4784 for severe @entity158 . 53% of the physicians were not aware of the 'Bangladesh Narcotics law, 1990'. 89% of the physicians would restrict opioid dosage in @entity158 management to prevent drug tolerance or addiction. Oncology physicians displayed significantly higher knowledge scores. The results demonstrated physicians' poor knowledge, attitude and perceived barriers regarding @entity4784 . Effective education strategies need to be addressed using the study result.

title: Physicians knowledge and attitude of opioid availability, accessibility and use in XXXX management in Bangladesh.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity6882 :: ('MESH:D008614', 'Chemical') :: ['pethidine']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: OBJECTIVE: @entity1 with @entity4309 have an increased risk of developing colorectal and gynecologic @entity5 such as @entity1204 . @entity1373 has about a 30% risk of developing into @entity1204 . The aim of this study was to determine the genetic risk for developing @entity1204 by immunohistochemical staining of @entity75 for @entity6756 , mutS homolog 2, mutS homolog 6, and postmeiotic segregation increased 2. METHODS: Twenty cases (n=20) were selected from among @entity1 with available sample blocks for analysis. Clinical information was obtained from medical chart review. Immunohistochemical staining was performed for all of the @entity5 blocks. Staining was scored based on the intensity (intensity score 0-3) . RESULTS: Among the 20 cases of @entity1869 , 11 (55%) @entity1 showed loss of expression of at least one of the following proteins: @entity6756 , mutS homolog 2, mutS homolog 6, or postmeiotic segregation increased 2. Seven (35%) @entity1 were negative for the expression of two or more proteins, and one @entity1 (5%) was negative for the expression of all four proteins. CONCLUSION: More than half of the @entity1 showed loss of expression of at least one mismatch repair protein in our study population. Genetic risk counseling and further tests are recommended for these @entity1 .

title: Clinical significance of mismatch repair genes immunohistochemical expression of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Women', 'patient']

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial cancer']

entities_list: @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch syndrome']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignancies']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['premalignant lesions']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['Complex hyperplasia']

entities_list: @entity1869 :: ('MESH:D004714', 'Disease') :: ['complex endometrial hyperplasia']

answer: @entity1869 :: (MESH:D004714,Disease) :: ['complex endometrial hyperplasia']


abstract: OBJECTIVE: To analyze the prognostic role of revised version of International Federation of Gynecology and Obstetrics (FIGO) stage (2013) in @entity43 and compare with previous version staging classification. METHODS: We retrospectively enrolled @entity1 with @entity43 treated at Samsung Medical Center from 2002 to 2012. We reclassified the @entity1 based on the revised FIGO staging classification. RESULTS: Eight hundred seventy-eight @entity1 were enrolled (stage I, 22.8%; stage II, 10.4%; stage III, 56.2%; stage IV, 10.7%). Previous stage IC (98, 11.1%) was subdivided into @entity32644 (9, 1.0%), @entity15539 (57, 6.4%), and IC3 (32, 4.1%). In addition, previous stage IV (94, 1.7%) was categorized into @entity3480 (37, 4.2%) and IVB (57, 6.5%) in new staging classification. Stage IIC (66, 7.5%) has been eliminated and integrated into IIA (36, 4.1%) and IIB (55, 6.2%) in revised classification. Revised FIGO stage IC3 had significant prognostic impact on PFS (hazard ratio [HR], 3.840; 95% confidence interval [CI], 1.361 to 10.83; P=0.011) and revised FIGO stage IIIC appears to be an independent, significant poor prognostic factor for PFS (HR, 2.541; 95% CI, 1.242 to 5.200; P=0.011) but not in the case of previous version of FIGO stage IIIC (HR, 1.070; 95% CI, 0.502 to 2.281; P=0.860). However, any sub-stages of both previous and revised version in stage II and IV, there was no significant prognostic role. CONCLUSION: Revised FIGO stage has more progressed utility for informing prognosis than previous version, especially in stage I and III. For stage II and IV, further validation should be needed in large population based study in the future.

title: Survival analysis of revised 2013 FIGO staging classification of XXXX and comparison with previous FIGO staging classification.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['epithelial ovarian cancer']

answer: @entity43 :: (MESH:D010051,Disease) :: ['epithelial ovarian cancer']


abstract: PURPOSE: Previous studies have demonstrated vertebral coplanar alignment (VCA) as an effective surgical option for @entity1615 ( @entity1615 ). The purpose of this study is to analyze the outcome of VCA for the surgical correction of adult @entity2112 (AdIS). METHODS: 35 AdIS @entity1 (mean age: 24.2  years) undergoing VCA-instrumentation were reviewed. The main thoracic curve and @entity1513 ( @entity1513 , T5-T12) were evaluated preoperatively, immediate postoperatively, and at the final follow-up (>1  year). All @entity1 were stratified by the @entity1513 modifier before surgery: "+" ( @entity1513 , >40  ), "-" ( @entity1513 , <10  ), and "N" ( @entity1513 , 10  -40  ) for normal. The apical vertebral body-to-rib ratio (AVB-R), rib hump (RH), and rotational angle to sacrum (RAsac) were measured to assess the correction of @entity717 . Quality of life was evaluated with @entity6815 -20 questionnaires. RESULTS: The main thoracic curve (59.1   vs. 19.3  , P  <  0.001) and @entity717 (AVB-R: 2.4 vs. 1.7  %, P  <  0.001, RH: 34.9 vs. 19.1  mm, P  <  0.001, RAsac: 19.6   vs. 11.9  , P  <  0.001) were significantly reduced with surgery. @entity85 improved significantly in group "+" (51.4   vs. 31.6  , P  <  0.001) and group "-" (6.2   vs. 20.1  , P  <  0.001), while no significant postoperative change in @entity1513 was observed in group "N" (23.5   vs. 26.3  , P  =  0.270). @entity1 were followed for an average of 18.7  months with no significant loss of correction. @entity6815 scores improved greatly from 57.7 preoperatively to 71.6 at the final follow-up. CONCLUSIONS: VCA can be effectively used for the correction of the @entity717 , with better sagittal profile restoration in adult thoracic @entity2112 with @entity893 .

title: Vertebral coplanar alignment technique: a surgical option for correction of adult thoracic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1615 :: ('OMIM:181800', 'Disease') :: ['AIS', 'adolescent idiopathic scoliosis']

entities_list: @entity1513 :: ('MESH:D007738', 'Disease') :: ['TK', 'thoracic kyphosis']

entities_list: @entity2112 :: ('MESH:C564593', 'Disease') :: ['idiopathic scoliosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['rotational deformity', 'coronal and rotational deformity']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['Sagittal deformity']

entities_list: @entity893 :: ('MESH:D017760', 'Disease') :: ['sagittal malalignment']

answer: @entity2112 :: (MESH:C564593,Disease) :: ['idiopathic scoliosis']


abstract: BACKGROUND: Sexuality is an important aspect of the personality of an individual and influences psychological, physical and social well-being of both @entity1 and @entity1 . It is a paradox, that in the country where 'kamasutra' (by Vatsyayana) took birth, there is a lack of research publications and sexuality related literature; hence the current study was conducted, to estimate the prevalence and association of @entity250 with various socio-demographic variables, in the selected rural population. MATERIALS AND METHODS: Subjects who were sexually active and fulfilled the study criteria were administered Arizona Sexual Experience Scale as screening tool for the presence of sexual problems. Those who were found to be having sexual problems were interviewed further using appropriate questionnaires. RESULTS: 21.15% of the male subjects were diagnosed to have one (or more) @entity250 . Prevalence of @entity323 was found to be 15.77%, male @entity458 ( @entity458 ) 2.56%; @entity2754 was found to be prevalent in 8.76% of the male subjects. Around 14% of the female subjects were diagnosed to have female @entity250 . Prevalence of female arousal dysfunction was found to be 6.65%, female @entity458 8.87%, female anorgasmia 5.67%, female @entity546 2.34% and female @entity458 was found to be prevalent in 0.37% of the female subjects. CONCLUSION: This study concluded that one in five males and one in seven females were suffering from one (or more) @entity250 . Improving the training of undergraduate medical and nursing students in sexuality related issues, increasing trained individuals in sexual medicine by starting new courses, providing sex education to the general population using media and merging sexual health care with primary care, are likely to play a significant role in addressing the increasing sexual health morbidity.

title: An epidemiological study of XXXX in south Indian rural population.

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['HSDD', 'sexual aversion disorder', 'hypoactive sexual desire disorder']

entities_list: @entity2754 :: ('MESH:D061686', 'Disease') :: ['premature ejaculation']

entities_list: @entity546 :: ('MESH:D004414', 'Disease') :: ['dyspareunia']

entities_list: @entity250 :: ('MESH:D012735', 'Disease') :: ['sexual disorders', 'sexual disorder']

answer: @entity250 :: (MESH:D012735,Disease) :: ['sexual disorders']


abstract: PURPOSE: We introduce a new method combined with the deformable image registration (DIR) and regions-of-interest mapping (ROIM) technique to accurately calculate dose on daily CBCT for @entity418 . METHODS: @entity1 suffered from @entity418 were enrolled in the study. Prescription was set to 66 Gy/30 F and 54 Gy/30 F to the @entity5 (PTV66) and subclinical disease (PTV54) . Planning CT (pCT) were segmented into 8 substructures in terms of their differences in physical density, such as gross target volume (GTV), venae cava superior ( @entity6480 ), aorta, heart, spinal cord, lung, muscle and bones. The pCT and its substructures were transferred to the MIM software to readout their mean HU values. Afterwards, a deformable planning CT to daily KV-CBCT image registration method was then utilized to acquire a new structure set on CBCT. The newly generated structures on CBCT were then transferred back to the treatment planning system (TPS) and its HU information were overridden manually with mean HU values obtained from pCT. Finally, the treatment plan was projected onto the CBCT images with the same beam arrangements and monitor units (MUs) to accomplish dose calculation. Planning target volume ( @entity343 ) and @entity347 ( @entity347 ) from both of the pCT and CBCT were compared to evaluate the dose calculation accuracy. RESULTS: It was found that the dose distribution in the CBCT showed little differences compared to the pCT, regardless of whether @entity343 or @entity347 were concerned. Specifically, dose variation in GTV, PTV54, PTV66, @entity6480 , lung and heart were within 0.1%. The maximum dose variation was presented in the spinal cord, which was up to 2.7% dose difference. CONCLUSION: The proposed method combined with DIR and ROIM technique to accurately calculate dose distribution on CBCT for @entity418 is feasible.

title: SU-E-J-100: The Combination of Deformable Image Registration and Regions-Of-Interest Mapping Technique to Accomplish Accurate Dose Calculation On Cone Beam Computed Tomography for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

entities_list: @entity347 :: ('MESH:D019965', 'Disease') :: ['organs at risk', 'OARs']

answer: @entity418 :: (MESH:D004938,Disease) :: ['Esophageal Cancer']