abstract: STUDY OBJECTIVE: In 2008, a pay-for-performance program was implemented in sequential waves in Ontario @entity341 ( @entity341 ), with the aim of reducing length of stay. We seek to evaluate its effects on @entity2613 length of stay and quality of care. METHODS: This was a retrospective observational study of @entity2613 visits in Ontario from April 1, 2007, to March 31, 2011, using multivariable difference-in-differences analysis. Pay-for-performance hospitals and matched control sites were selected for each of 3 waves of the program. The primary outcome was 90th percentile @entity2613 length of stay; we also examined quality-of-care indicators. RESULTS: Pay-for-performance hospitals had a modest reduction in overall adjusted 90th percentile @entity2613 length of stay in @entity13830 (-36 minutes; 95% confidence interval [CI] -50 to -21 minutes), but not in @entity13831 (-14 minutes; 95% CI -30 to 2 minutes) or @entity27399 (-7 minutes; 95% CI -23 to 8 minutes). @entity2613 admitted @entity1 had a pronounced reduction in adjusted 90th percentile length of stay in @entity13830 (-225 minutes; 95% CI -263 to -188 minutes) and @entity13831 (-133 minutes; 95% CI -175 to -91 minutes). Nonadmitted low-acuity @entity1 had reductions in adjusted 90th percentile @entity2613 length of stay in @entity13830 (-24 minutes; 95% CI -29 to -18 minutes) and @entity27399 (-19 minutes; 95% CI -24 to -14 minutes). The program did not negatively affect @entity2613 quality-of-care measures, such as 30-day mortality or readmission rates. CONCLUSION: Pay-for-performance was associated with modest overall benefits for @entity2613 length of stay without adversely affecting quality of care.

title: The Effect of Pay for Performance in the Emergency Department on XXXX Waiting Times and Quality of Care in Ontario, Canada: A Difference-in-Differences Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency departments', 'EDs']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: OBJECTIVE: Increasingly, @entity12203 and @entity2122 are recognized as risk factors for @entity27 . We sought to determine whether @entity1 with these diagnoses have become more likely to undergo inpatient polysomnogram (PSG) over time and to identify evolving trends in PSG utilization. METHODS: Retrospective analysis of the Kids' Inpatient Database from 2003 to 2012. @entity1 <21 years who underwent PSG were included. Weighted comparisons of clinical/demographic characteristics of @entity1 undergoing PSG were performed, as were associations between clinical and demographic @entity1 characteristics and performance of inpatient PSG. RESULTS: Between 2003 and 2012, PSG procedures decreased from 1266 to 829 (P < .001). Among @entity1 who underwent PSG, mean age decreased from 3.9    5.1 to 3.1    5.2 years (P = .001), and the frequency of age <1 year increased from 47.8% to 59.5% (P < .001). The frequency of @entity12203 increased from 2.5% to 14.3% (P < .001), while the frequency of @entity2122 increased from 6.2% to 19.4% (P < .001). @entity12203 and @entity2122 were predictive of undergoing inpatient PSG in both timeframes. CONCLUSION: Despite decreasing PSG volumes, diagnoses of @entity12203 and @entity2122 comprised increasing fractions of @entity1 undergoing inpatient PSG between 2003 and 2012. @entity12203 and @entity2122 were also predictive of inpatient PSG use in both timeframes.

title: Trends in Inpatient Pediatric Polysomnography for XXXX and @entity2122 .

entities_list: @entity2122 :: ('MESH:D019465', 'Disease') :: ['craniofacial anomalies']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'Children', 'patient']

entities_list: @entity12203 :: ('MESH:D055092', 'Disease') :: ['laryngomalacia', 'Laryngomalacia']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea']

answer: @entity12203 :: (MESH:D055092,Disease) :: ['Laryngomalacia']


abstract: OBJECTIVE: Increasingly, @entity12203 and @entity2122 are recognized as risk factors for @entity27 . We sought to determine whether @entity1 with these diagnoses have become more likely to undergo inpatient polysomnogram (PSG) over time and to identify evolving trends in PSG utilization. METHODS: Retrospective analysis of the Kids' Inpatient Database from 2003 to 2012. @entity1 <21 years who underwent PSG were included. Weighted comparisons of clinical/demographic characteristics of @entity1 undergoing PSG were performed, as were associations between clinical and demographic @entity1 characteristics and performance of inpatient PSG. RESULTS: Between 2003 and 2012, PSG procedures decreased from 1266 to 829 (P < .001). Among @entity1 who underwent PSG, mean age decreased from 3.9    5.1 to 3.1    5.2 years (P = .001), and the frequency of age <1 year increased from 47.8% to 59.5% (P < .001). The frequency of @entity12203 increased from 2.5% to 14.3% (P < .001), while the frequency of @entity2122 increased from 6.2% to 19.4% (P < .001). @entity12203 and @entity2122 were predictive of undergoing inpatient PSG in both timeframes. CONCLUSION: Despite decreasing PSG volumes, diagnoses of @entity12203 and @entity2122 comprised increasing fractions of @entity1 undergoing inpatient PSG between 2003 and 2012. @entity12203 and @entity2122 were also predictive of inpatient PSG use in both timeframes.

title: Trends in Inpatient Pediatric Polysomnography for @entity12203 and XXXX .

answer: @entity2122 :: (MESH:D019465,Disease) :: ['Craniofacial Anomalies']


abstract: PURPOSE: To evaluate the role of endovascular treatment for controlling @entity548 in haemodynamically unstable @entity1 with @entity174 and to relate clinical efficacy to pre-procedural variables. MATERIALS AND METHODS: From March 2009 through April 2013, 168 @entity1 with major pelvic @entity130 associated with high-flow @entity548 were referred to our emergency department and were retrospectively reviewed. Pelvic arteries involved were one or more per @entity1 . Embolisation was performed using various materials (micro-coils, Spongostan, plug, glue, covered stent), and technical success, complications, treatment success, clinical efficacy, rebleeding, and mortality rates were assessed. Factors influencing clinical efficacy were also evaluated. RESULTS: The technical success rate was 100  %; no complications occurred during the procedures. Treatment was successful in 94.6  % cases, and clinical efficacy was 85.7  %. Three @entity1 had to undergo a second arteriography due to recurrent @entity548 . Fifteen @entity1 died. Pre-embolisation transfusion demand was significantly associated with clinical efficacy. CONCLUSIONS: Percutaneous embolisation of @entity548 may be considered a safe, effective, and minimally invasive therapeutic option. As haemodynamic stability is the first objective with traumatic @entity548 @entity1 , arterial embolisation can assume a primary role. On the basis of our results, pre-procedural transfusion status may be considered a prognostic factor. KEY POINTS:     The series presented is one of the largest in a single centre.     @entity432 is a life-saving procedure in @entity1 with @entity548 .     In pelvic @entity130 associated with @entity548 , prognosis is dependent upon prompt treatment.     Transfusion status is significantly related to clinical efficacy.

title: The role of endovascular treatment of pelvic XXXX bleeding in emergency settings.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['pelvic bone fractures']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['pelvic haemorrhage', 'haemorrhage', 'haemorrhagic', 'pelvic bleeding']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['Arterial embolisation']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumas', 'trauma']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture']


abstract: Recent data has indicated that, besides its classical therapeutic indication in hyperurecemia and gout, @entity35146 inhibitors can be used to various forms of @entity63 and other types of tissue and @entity1317 . We tested the hypothesis that allopurinol, an inhibitor of @entity35146 ( @entity35146 ), might modulate acute and/or chronic inflammatory angiogenesis induced by subcutaneous implantation of synthetic matrix in @entity19 . C57/BL6 male @entity19 (6-7 weeks) were implanted with polyether-polyurethane sponge discs. The animals received by oral gavage 1.0mg/kg of allopurinol for six consecutive days in two treatment regimen. In the first series of experiments, the treatment was initiated 24h post-implantation and the implants were removed at day 7 post-implantation. For the assessment of the effect of the compound on @entity32 , the treatment was initiated at day 8 post-implantation and the implants removed 14days post-implantation. Angiogenesis as determined by hemoglobin content, @entity1611 levels and number of vessels intraimplant, and @entity32 (myeloperoxidase -MPO, n-acetyl-b-d-glucosaminidase - @entity33794 , @entity637 and @entity1750 levels) were reduced by allopurinol treatment in acute phase. Similarly, the treatment inhibited nitric oxide and H2O2 production. However, fibrogenesis determined by collagen deposition and levels of @entity641 increased in the implants after allopurinol treatment. In marked contrast with the effects when the treatment initiated 24h post-implantation, allopurinol increased angiogenesis and @entity32 but reduced collagen and @entity641 levels intra-implant, when the treatment was started during the chronic inflammatory process. The dual effects of allopurinol described here, extend its range of actions as a potential agent able to modulate the components of the fibrovascular tissue present in both physiological (healing processes) as well as in chronic @entity66 . These modulatory effects depended on the phase at which the treatment was initiated.

title: Angiopreventive versus angiopromoting effects of allopurinol in the XXXX sponge model.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'inflammation']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['fibroproliferative diseases']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity1317 :: ('MESH:D057772', 'Disease') :: ['vascular injuries']

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: PURPOSE: @entity7494 ( @entity7494 ) is a condition of severe @entity390 or @entity391 accompanied by various complications during pregnancy. In the present study, we aimed to demonstrate the effects of @entity7494 on mother and fetus health. METHODS: Control and case group were arranged from 50 healthy pregnant @entity1 and 50 pregnant @entity1 with @entity7494 . Information about the @entity1 @entity1 was gathered with data collection form and Beck's @entity308 Inventory (BDI) and State Anxiety Inventory (SAI) were administered to the @entity1 . Following an abortion or delivery, the data about birth complications and neonatal health were collected. All laboratory results (blood count, thyroid hormones, electrolyte values and biochemical parameters) were gathered from the laboratory information system used in the hospital. RESULTS: It was found that in the case group, mean postpartum weight, serum hemoglobin, hematocrit and thyroid stimulant hormone levels were lower than control group (p  <  0.01). Conversely, case group @entity1 have higher T3 and T4 levels than control group (p  <  0.01). There was no significant difference between the two groups in terms of @entity1592 , low birth weight and abortion but it was observed that @entity1 with @entity7494 had often delivered prematurely. The mean scores of BDI and SAI in the case group were higher than those of control group. CONCLUSION: These results suggested that @entity7494 may have adverse effects on both mother and baby's health. Pregnant @entity1 with @entity7494 should be provided with training and consultancy services and be closely monitored in terms of @entity417 and thyroid hormones.

title: XXXX affects maternal sanity, thyroid hormones and fetal health: a prospective case control study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'participant']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity7494 :: ('MESH:D006939', 'Disease') :: ['Hyperemesis gravidarum', 'HG']

entities_list: @entity1592 :: ('MESH:D005317', 'Disease') :: ['intrauterine growth retardation']

answer: @entity7494 :: (MESH:D006939,Disease) :: ['Hyperemesis gravidarum']


abstract: BACKGROUND: The majority of @entity1 with @entity1419 ( @entity1419 ) who undergo complete @entity5 resection subsequently develop @entity5 recurrence. The objectives of this study were to determine the risk factors for @entity1419 recurrence after curative (R0) liver resection and to identify the feasibility about postoperative adjuvant @entity1161 ( @entity1161 ). METHODS: We retrospectively reviewed @entity1 who underwent liver resection for @entity1419 between April 1995 and December 2012 at Samsung Medical Center. Cox regression analysis was performed to determine risk factors of recurrence. @entity1 with a recurrence in remnant liver within 2  cm from the resection margin, with or without locoregional lymph node (LN) @entity3 , were considered as potential @entity1161 candidates. Center-of-mass (COM) distances between the recurrent @entity5 and the cut surface were measured with MATLAB. RESULTS: We included 153 out of 198 @entity1 who underwent partial liver resection for @entity1419 . About two thirds (n   =   93, 60.8  %) of @entity1 developed recurrent disease. The median recurrence-free survival (RFS) was 14  months (range, 0-204). @entity5 size >= 4.0  cm, LN @entity3 and @entity5 were significant predictors of @entity1419 recurrence on multivariate analysis. @entity5 size >= 5.0  cm was the only factor associated with recurrence beyond the @entity1161 field in @entity1 with recurrence. Among 93 @entity1 with recurrence, 16 (17.2  %) @entity1 were recurred in the @entity1161 field. CONCLUSION: After curative resection in @entity1419 , more than 60  % of @entity1 recurred, and among recurred @entity1 , 17.2  % were recurred within the @entity1161 field. Consequently, for control of locoregional recurrence, adjuvant @entity1161 could be carefully considered in @entity1 with recurrence factors. Especially, @entity1 with a @entity5 size larger than 5  cm should be judiciously selected for adjuvant @entity1161 .

title: Predictors and patterns of recurrence after curative liver resection in XXXX , for application of postoperative radiotherapy: a retrospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'multiple tumors', 'cancers', 'Tumor']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation therapy', 'RT']

entities_list: @entity1419 :: ('MESH:C535533', 'Disease') :: ['IHCC', 'intrahepatic cholangiocarcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'metastases']

answer: @entity1419 :: (MESH:C535533,Disease) :: ['intrahepatic cholangiocarcinoma']


abstract: UNASSIGNED: Charged particle therapy is generally regarded as cutting-edge technology in oncology. Many proton therapy centres are active in the USA, Europe, and Asia, but only a few centres use heavy ions, even though these ions are much more effective than x-rays owing to the special radiobiological properties of densely ionising radiation. The National Institute of Radiological Sciences (NIRS) Chiba, Japan, has been treating @entity5 with high-energy @entity505 ions since 1994. So far, more than 8000 @entity1 have had this treatment at NIRS, and the centre thus has by far the greatest experience in @entity505 ion treatment worldwide. A panel of radiation oncologists, radiobiologists, and medical physicists from the USA and Europe recently completed peer review of the @entity505 ion therapy at NIRS. The review panel had access to the latest developments in treatment planning and beam delivery and to all updated clinical data produced at NIRS. A detailed comparison with the most advanced results obtained with x-rays or protons in Europe and the USA was then possible. In addition to those @entity5 for which @entity505 ions are known to produce excellent results, such as bone and soft-tissue sarcoma of the skull base, head and neck, and pelvis, promising data were obtained for other @entity5 , such as locally recurrent @entity5 and @entity788 . The most serious impediment to the worldwide spread of heavy ion therapy centres is the high initial capital cost. The 20 years of clinical experience at NIRS can help guide strategic decisions on the design and construction of new heavy ion therapy centres.

title: XXXX ion radiotherapy in Japan: an assessment of 20 years of clinical experience.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours', 'rectal cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['Carbon']


abstract: UNASSIGNED: Non-synonymous single @entity4334 variants (nsSNVs) in coding DNA regions can result in phenotypic differences between individuals; however, only some nsSNVs are causative for a certain disease. As just a fraction of respective nsSNVs is annotated in databases, computational biology tools are applied to predict the pathogenicity in silico. In addition to applications in oncology, novel molecular diagnostic tests have been developed for @entity65 as a leading cause of morbidity and mortality in industrialized nations. We explored the concordance and performance of 13 nsSNV pathogenicity prediction tools on panel sequencing results of @entity384 . The analyzed data set from the INHERITANCE study contained 842 nsSNVs discovered in 639 @entity1 , screened for the full sequence of 76 genes related to @entity296 . The single tools prediction revealed a surprisingly high heterogeneity and discordance based on the implemented prediction method. Known disease associations were not reported by the tools, limiting usability in clinics. Because different tools have different advantages, we combined their results. By clustering of correlated methods using similar prediction strategies and calculating a majority vote-based consensus, we found that the prediction accuracy and sensitivity can be further improved. Although challenges remain, different in silico tools bear the potential to predict the @entity5 , especially if different algorithms are combined. Most tools rely mainly on sequence features; beyond these, structural information is important to analyze the relationship of nsSNVs with disease phenotypes. Likewise, current tools consider single nsSNVs, which may, however, show a cumulative effect and turn neutral mutations in an ensemble into pathogenic variants.

title: Pathogenicity prediction of non-synonymous single XXXX variants in @entity384 .

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathies']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy of nsSNVs']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['dilated cardiomyopathy']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disorders']

answer: @entity4334 :: (D009711,Chemical) :: ['nucleotide']


abstract: UNASSIGNED: Non-synonymous single @entity4334 variants (nsSNVs) in coding DNA regions can result in phenotypic differences between individuals; however, only some nsSNVs are causative for a certain disease. As just a fraction of respective nsSNVs is annotated in databases, computational biology tools are applied to predict the pathogenicity in silico. In addition to applications in oncology, novel molecular diagnostic tests have been developed for @entity65 as a leading cause of morbidity and mortality in industrialized nations. We explored the concordance and performance of 13 nsSNV pathogenicity prediction tools on panel sequencing results of @entity384 . The analyzed data set from the INHERITANCE study contained 842 nsSNVs discovered in 639 @entity1 , screened for the full sequence of 76 genes related to @entity296 . The single tools prediction revealed a surprisingly high heterogeneity and discordance based on the implemented prediction method. Known disease associations were not reported by the tools, limiting usability in clinics. Because different tools have different advantages, we combined their results. By clustering of correlated methods using similar prediction strategies and calculating a majority vote-based consensus, we found that the prediction accuracy and sensitivity can be further improved. Although challenges remain, different in silico tools bear the potential to predict the @entity5 , especially if different algorithms are combined. Most tools rely mainly on sequence features; beyond these, structural information is important to analyze the relationship of nsSNVs with disease phenotypes. Likewise, current tools consider single nsSNVs, which may, however, show a cumulative effect and turn neutral mutations in an ensemble into pathogenic variants.

title: Pathogenicity prediction of non-synonymous single @entity4334 variants in XXXX .

answer: @entity384 :: (MESH:D002311,Disease) :: ['dilated cardiomyopathy']


abstract: PURPOSE: To validate electronic versions of the Mini Pediatric and Pediatric Asthma Caregiver's Quality of Life Questionnaires (MiniPAQLQ and PACQLQ, respectively), determine completion times and correlate QOL of @entity1 and caregivers. METHODS: A total of 63 @entity1 and 64 caregivers completed the paper and electronic MiniPAQLQ or PACQLQ. Agreement between versions of each questionnaire was summarized by intraclass correlation coefficients (ICC). The correlation between MiniPAQLQ and PACQLQ scores from @entity1 -caregiver pairs was assessed using Pearson's correlation coefficient. RESULTS: There was no significant difference (mean difference  =  0.1, 95  % CI -0.1, 0.2) in MiniPAQLQ Overall Scores between paper (5.9      1.0, mean      SD) and electronic (5.8      1.0) versions, or any of the domains. ICCs ranged from 0.89 (Overall) to 0.86 (Emotional Function). Overall PACQLQ scores for both versions were comparable (5.9      0.9 and 5.8      1.0; mean difference  =  0.0; 95  % CI -0.1, 0.2). ICCs ranged from 0.81 (Activity Limitation) to 0.88 (Emotional Function). The electronic PACQLQ took 26  s longer (95  % CI 11, 41; p  <  0.001). Few @entity1 (3-11  %) preferred the paper format. MiniPAQLQ and PACQLQ scores were significantly correlated (all p  <  0.05) for Overall (r paper  =  0.33, r electronic  =  0.27) and Emotional Function domains (r paper  =  0.34, r electronic  =  0.29). CONCLUSIONS: These electronic QOL questionnaires are valid, and @entity565 -related QOL of @entity1 and caregivers is related.

title: Assessing the burden of childhood XXXX : validation of electronic versions of the Mini Pediatric and Pediatric Asthma Caregiver's Quality of Life Questionnaires.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'child', 'children']

answer: @entity565 :: (MESH:D001249,Disease) :: ['asthma']


abstract: PURPOSE: The purpose of this study was to evaluate the psychometric properties of the Farsi version of 10-item Functional Outcomes of Sleep Questionnaire (FOSQ-10) in Iranian @entity1 with @entity27 ( @entity27 ). METHODS: The FOSQ-10 was translated into Farsi using the standard forward-backward method. One hundred @entity1 who fulfilled the inclusion criteria completed a series of questionnaires including IR-FOSQ-10, Medical Outcome Survey Short Form 12 (SF-12) and @entity25 ( @entity25 ). Internal consistency, test-retest reliability, concurrent validity, discriminant validity and responsiveness of IR-FOSQ-10 were investigated. RESULTS: The Cronbach's alpha coefficient was 0.85 in IR-FOSQ-10 total score and ranged from 0.78 to 0.83 in each subscale. The test-retest reliability demonstrated by intraclass coefficient was 0.92. There were significant moderate-to-good negative correlations between IR-FOSQ-10 subscales and @entity25 except for sexual relationship subscale. FOSQ-10 subscales generally correlated higher with related subscales of SF-12. The IR-FOSQ-10 was able to distinguish @entity1 with @entity25 score from those with normal sleepiness score. The results of sensitivity to change proved that the IR-FOSQ-10 was able to detect changes after continuous positive airway pressure therapy. CONCLUSION: The psychometric properties of the IR-FOSQ-10 suggest that it is a reliable and valid measure among Iranian @entity1 with @entity27 .

title: Adaptation of the 10-Item Functional Outcomes of Sleep Questionnaire to Iranian XXXX with Obstructive Sleep Apnea.

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['Epworth Sleepiness Scale', 'abnormal sleepiness', 'ESS']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: The objective of this study was to determine the effect of different levels of dietary @entity1853 on selected immune parameters of young @entity233 . A total of 357 one-day-old female Hybrid Converter @entity233 were randomly divided into three groups with low, medium and high level of dietary me- @entity32341 (LM, MM, HM) of seven replicates each. @entity1853 was added to the basal diet (LM) at 0.16% (MM) and 0.32% (HM). At 17 days of age, seven birds per group were vaccinated against @entity281 , with ORNITIN (ABIC) vaccine. At 28 days of age, blood was sampled and the birds were euthanized. The serum concentrations and activity of selected biochemical parameters, total IgY and IgM, and vaccine-induced antibody titers (IgY) against ORT were determined. The percentages of @entity71492 +, @entity71493 +, @entity71492 +/ @entity71493 + T cell subpopulations and IgM+ B cell subpopulation were determined in blood and organs by flow cytometry. Different supplementary levels of @entity1853 had no significant effect on vaccine-induced anti- body titers against ORT or total serum IgM and IgY levels, as well as on the percentages of periph- eral blood T and B cell subsets. Increasing dietary @entity1853 rates decreased the percentage of @entity71492 + T cell subpopulation, however it has increased the percentage of IgM+ B cell subpopulation in the spleen. Vaccination against ORT resulted in a significant decrease in the percentage of @entity71492 + T cell subset and an increase in the percentage of @entity71493 + T cell subset in the spleen. It could be concluded that MM @entity233 have developed the most desirable values of immune parameters.

title: Immunological and biochemical indicators in XXXX fed diets with a different @entity1853 content.

entities_list: @entity1853 :: ('MESH:D008715', 'Chemical') :: ['Methionine', 'methionine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['Ornithobacterium rhinotraheale (ORT) infection']

answer: @entity233 :: (9103,Species) :: ['turkeys']


abstract: The objective of this study was to determine the effect of different levels of dietary @entity1853 on selected immune parameters of young @entity233 . A total of 357 one-day-old female Hybrid Converter @entity233 were randomly divided into three groups with low, medium and high level of dietary me- @entity32341 (LM, MM, HM) of seven replicates each. @entity1853 was added to the basal diet (LM) at 0.16% (MM) and 0.32% (HM). At 17 days of age, seven birds per group were vaccinated against @entity281 , with ORNITIN (ABIC) vaccine. At 28 days of age, blood was sampled and the birds were euthanized. The serum concentrations and activity of selected biochemical parameters, total IgY and IgM, and vaccine-induced antibody titers (IgY) against ORT were determined. The percentages of @entity71492 +, @entity71493 +, @entity71492 +/ @entity71493 + T cell subpopulations and IgM+ B cell subpopulation were determined in blood and organs by flow cytometry. Different supplementary levels of @entity1853 had no significant effect on vaccine-induced anti- body titers against ORT or total serum IgM and IgY levels, as well as on the percentages of periph- eral blood T and B cell subsets. Increasing dietary @entity1853 rates decreased the percentage of @entity71492 + T cell subpopulation, however it has increased the percentage of IgM+ B cell subpopulation in the spleen. Vaccination against ORT resulted in a significant decrease in the percentage of @entity71492 + T cell subset and an increase in the percentage of @entity71493 + T cell subset in the spleen. It could be concluded that MM @entity233 have developed the most desirable values of immune parameters.

title: Immunological and biochemical indicators in @entity233 fed diets with a different XXXX content.

answer: @entity1853 :: (MESH:D008715,Chemical) :: ['Methionine']


abstract: OBJECTIVE: To investigate the feasibility and short-term effectiveness of percutaneous endoscopic spine surgery for treatment of @entity890 with posterior ring apophysis separation. METHODS: Between July 2008 and January 2013, 57 @entity1 with @entity890 and posterior ring apophysis separation were treated. There were 39 males and 18 females, aged from 13 to 46 years (mean, 26.7 years). Of 57 cases, 29 had a clear @entity130 history. All @entity1 had @entity890 , and the location was at L4, 5 in 22 cases and at L5, S1 in 35 cases; there were 25 cases of lateral bone fragments and 32 cases of central cortical and cancellous fragments. While @entity174 located at posterior inferior edge of the vertebrae at L4 level in 9 cases and at Ls level in 8 cases, at posterior superior edge at L5 level in 13 cases and in S1 level in 27 cases. Percutaneous endoscopic surgeries were performed via interlaminar or transforaminal approach from unilaterally symptomatic side for discectomy of @entity890 and partial or complete resection of free bone fragments. RESULTS: Accurate positioning was obtained in all @entity1 during operation, and no complication of nerve @entity130 , @entity1410 formation, or dural tear occurred. The operation time was 20-85 minutes; the intraoperative fluoroscopy times were 2-15 times, and the @entity190 was 3-10 mL. Postoperative radiographic examination showed that bone fragment was not removed in 16 cases, was partly removed in 32 cases, and was completely removed in 9 cases. Disc was completely removed. All @entity1 were followed up 10-64 months (median, 16 months). According to modified Macnab criteria for the evaluation of effectiveness, the results were excellent in 48 cases, good in 6 cases, and fair in 3 cases, and the excellent and good rate was 94.7%. CONCLUSION: Percutaneous endoscopic spine surgery through unilaterally symptomatic approach has advantages of small tissue damage and lumbar structure damage, less @entity548 , and shorter recovery time. It has a good short-term effectiveness, but long-term effectiveness need further follow-up.

title: [Short-term effectiveness of percutaneous endoscopic spine surgery for treatment of XXXX with posterior ring apophysis separation].

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['root injury', 'trauma']

entities_list: @entity890 :: ('MESH:D007405', 'Disease') :: ['single segmental unilateral lumbar disc herniation', 'lumbar disc herniation']

answer: @entity890 :: (MESH:D007405,Disease) :: ['lumbar disc herniation']


abstract: UNASSIGNED: Ganoderma lucidum, a hallmark of traditional Chinese medicine, has been widely used as a pharmacologically active compound. Although numerous research studies have focused on the pharmacological mechanism, fewer studies have explored the basic biological features of this species, restricting the further development and application of this important mushroom. Because of the ability of this mushroom to reduce and detoxify the compounds produced by various metabolic pathways, @entity2041 peroxidase (GPx) is one of the most important antioxidant enzymes with respect to ROS. Although studies in both animals and plants have suggested many important physiological functions of GPx, there are few systematic research studies concerning the role of this enzyme in fungi, particularly in large basidiomycetes. In the present study, we cloned the GPx gene and created GPx-silenced strains by the down-regulation of GPx gene expression using RNA interference. The results indicated an essential role for GPx in controlling the intracellular @entity5568 content, hyphal branching, antioxidant stress tolerance, cytosolic @entity141 content and @entity64656 biosynthesis. Further mechanistic investigation revealed that GPx is regulated by intracellular @entity5568 levels and suggested that crosstalk occurs between GPx and intracellular @entity5568 . Moreover, evidence was obtained indicating that GPx regulation of hyphal branching via ROS might occur independently of the cytosolic @entity141 content. Further mechanistic investigation also revealed that the effects of GPx on @entity64656 synthesis via ROS are regulated by the cytosolic @entity141 content. Taken together, these findings indicate that ROS have a complex influence on growth, development and secondary metabolism in fungi and that GPx serves an important function. The present study provides an excellent framework to identify GPx functions and highlights a role for this enzyme in ROS regulation.

title: Functional analysis of the role of @entity2041 peroxidase (GPx) in the ROS signaling pathway, hyphal branching and the regulation of XXXX biosynthesis in Ganoderma lucidum.

entities_list: @entity64656 :: ('MESH:C556862', 'Chemical') :: ['ganoderic acid']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

answer: @entity64656 :: (MESH:C556862,Chemical) :: ['ganoderic acid']


abstract: UNASSIGNED: Ganoderma lucidum, a hallmark of traditional Chinese medicine, has been widely used as a pharmacologically active compound. Although numerous research studies have focused on the pharmacological mechanism, fewer studies have explored the basic biological features of this species, restricting the further development and application of this important mushroom. Because of the ability of this mushroom to reduce and detoxify the compounds produced by various metabolic pathways, @entity2041 peroxidase (GPx) is one of the most important antioxidant enzymes with respect to ROS. Although studies in both animals and plants have suggested many important physiological functions of GPx, there are few systematic research studies concerning the role of this enzyme in fungi, particularly in large basidiomycetes. In the present study, we cloned the GPx gene and created GPx-silenced strains by the down-regulation of GPx gene expression using RNA interference. The results indicated an essential role for GPx in controlling the intracellular @entity5568 content, hyphal branching, antioxidant stress tolerance, cytosolic @entity141 content and @entity64656 biosynthesis. Further mechanistic investigation revealed that GPx is regulated by intracellular @entity5568 levels and suggested that crosstalk occurs between GPx and intracellular @entity5568 . Moreover, evidence was obtained indicating that GPx regulation of hyphal branching via ROS might occur independently of the cytosolic @entity141 content. Further mechanistic investigation also revealed that the effects of GPx on @entity64656 synthesis via ROS are regulated by the cytosolic @entity141 content. Taken together, these findings indicate that ROS have a complex influence on growth, development and secondary metabolism in fungi and that GPx serves an important function. The present study provides an excellent framework to identify GPx functions and highlights a role for this enzyme in ROS regulation.

title: Functional analysis of the role of XXXX peroxidase (GPx) in the ROS signaling pathway, hyphal branching and the regulation of @entity64656 biosynthesis in Ganoderma lucidum.

answer: @entity2041 :: (MESH:D005978,Chemical) :: ['glutathione']


abstract: UNASSIGNED: Objective   The timely detection of @entity16 can be critical for the survival of a neurosurgical @entity1 following @entity542 . Because little reliable evidence is available on the prognostic value of the clinical sign "extensor response" in @entity772 posttraumatic @entity1 , we investigated the correlation of this clinical sign with outcome and with early radiologic findings from magnetic resonance imaging (MRI). Methods   This retrospective analysis of prospectively obtained data included 157 @entity1 who had remained in a @entity772 for a minimum of 24 hours after @entity131 . All @entity1 received a 1.5-T MRI within 10 days (median: 2 days) of the injury. The correlations between clinical findings 12 and 24 hours after the injury-in particular, extensor response and pupillary function, MRI findings, and outcome after 1 year-were investigated. Statistical analysis included contingency tables, Fisher exact test, odds ratios (ORs) with confidence intervals (CIs), and weighted k values. Results   There were 48 @entity1 with extensor response within the first 24 hours after the injury. @entity1 with extensor response (World Federation of Neurosurgical Societies @entity772 grade III) statistically were significantly more likely to @entity75 in the brainstem when compared with @entity1 in a @entity772 who had no further deficiencies ( @entity772 grade I; p   =   0.0004 by Fisher exact test, OR 10.8 with 95% CI, 2.7-42.5) and @entity1 with unilateral loss of pupil function ( @entity772 grade II; p   =   0.0187, OR 2.8 with 95% CI, 1.2-6.5). The correlation of @entity75 as found by MRI and outcome according to the Glasgow Outcome Scale after 1   year was also highly significant (p    <=   0.016). Conclusion   The correlation of extensor response and loss of pupil function with an unfavorable outcome and with @entity75 revealed by MRI is highly significant. Their sudden onset may be associated with the @entity1164 and should therefore be regarded as one of the most fundamental warning signs in the clinical monitoring of @entity772 @entity1 .

title: Clinical, Radiologic, and Legal Significance of "Extensor Response" in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden onset of brainstem dysfunction']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['traumatic brain injury']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['harbor MRI lesions', 'brainstem lesions']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic deterioration']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury']

entities_list: @entity772 :: ('MESH:D003128', 'Disease') :: ['coma', 'comatose']

answer: @entity772 :: (MESH:D003128,Disease) :: ['Posttraumatic Coma']


abstract: BACKGROUND: Severe haemolysis is a rare complication after mitral valve repair in @entity299 . AIM: We describe four @entity1 with severe @entity339 who underwent valve repair and subsequently developed profound @entity417 . METHODS: Clinical, echocardiographic and surgical data were collected retrospectively from a surgical centre in France during a 5-year period. RESULTS: Two @entity1 had @entity474 , one @entity1 had @entity339 and one had anomalous left coronary artery from the pulmonary artery with @entity339 . Haemolysis was diagnosed 20 to 75days after surgery, as a result of clinical and biological examination; it was severe, and blood transfusion support was necessary in all cases. Haemolysis was always associated with eccentric @entity339 with a variable degree of severity (from low to severe). After exclusion of other haemolysis aetiology, redo mitral repair surgery was performed successfully in all cases. The haemolysis was considered to be mechanical in origin, caused by regurgitation of blood through the residual @entity339 and stitches. CONCLUSION: Severe haemolysis is a rare complication that can occur after mitral valve repair in @entity299 . All @entity1 underwent successful redo repair and had resolution of haemolysis after surgery. Even if redo surgery is required, iterative mitral repair is possible.

title: Repeat mitral valve repair for haemolysis in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['mitral regurgitation', 'congenital mitral dysplasia']

entities_list: @entity417 :: ('MESH:D000740', 'Disease') :: ['haemolytic anaemia']

entities_list: @entity474 :: ('MESH:C562831', 'Disease') :: ['atrioventricular septal defects']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: The concept of @entity1817 is defined by a group of clinical and electrocardiographic features related to @entity1817 whatever its mechanism; the organicity of the disease can be proven if total or subtotal histological alterations of the sinus node are demonstrated. The most typical symptoms are neurological ( @entity1163 and @entity1296 ). @entity16507 , sinus @entity1168 or @entity1168 , and the @entity1168 - @entity591 syndrome are the most usual electrocardiographic aspects. The diagnosis is often rendered difficult by the usually intermittent and frequently nonspecific character of the symptoms and of the ECG signs. Holter monitoring is often essential to resolve these difficulties. If the diagnosis remains dubious, the use of electrophysiological methods is necessary: direct recording of the sinus nodal intracardiac potential can now be added to the classical rapid and premature atrial stimulation, possibly complemented by pharmacological tests. Finally, therapeutic indications can be considered after a correct clinical, electrocardiographical and electrophysiological evaluation of the @entity1 . Medical treatment alone is usually ineffective in controlling the attacks of @entity943 and the @entity16 . If the sinus @entity409 is obvious and symptomatic, permanent pacing is the treatment of choice. Its short and medium term results are generally excellent, while the long term results, especially with regard to survival of the @entity1 , could be improved by the most recent pacing techniques.

title: [ XXXX - diagnosis and treatment].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological episodes']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['nodal dysfunction']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity1817 :: ('MESH:D012804', 'Disease') :: ['sinus node disease', 'sinus node dysfunction']

entities_list: @entity16507 :: ('MESH:D054138', 'Disease') :: ['Sinoatrial block, sinus arrest']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia', 'bradyarrhythmia']

answer: @entity1817 :: (MESH:D012804,Disease) :: ['Sinus node disease']


abstract: PURPOSE: To compare the subfoveal, parafoveal, and peripapillary @entity2194 with those of fellow and control eyes. METHODS: This institutional study involved 114 eyes from 38 @entity1 with unilateral @entity4457 and 19 healthy @entity1 , aged 6 to 17 years. The cause of @entity4457 was identified as hyperopic @entity9340 in 17 cases and strabismus in 21 cases. All @entity1 underwent central macular thickness (CMT) and @entity3193 at seven retinal sites with spectral-domain optical coherence tomography (OCT). Statistical analysis was performed to compare the CMT and @entity2194 with control eyes. RESULTS: Average CMT was 248.31    24.18  m in amblyopic eyes, 249.76    26.08  m in fellow eyes, and 243.65    31.96  m in controls (P = .604). Average subfoveal choroidal thickness was 394.15    71.03  m in amblyopic eyes, 356.07    79.93  m in fellow eyes, and 319.44    87.29  m in controls (P = .000). The choroidal thickness of the subfoveal area and at 750- m intervals temporal and nasal to the fovea was significantly thicker in amblyopic eyes than in controls (P < .05). The choroidal thickness was significantly thicker in amblyopic eyes than in fellow eyes only at 750  m nasal to the fovea. Type and depth of @entity4457 did not differ significantly between foveal or parafoveal choroidal thickness (P > .05). There was a significant negative correlation between the nasal peripapillary choroidal thickness and the axial length in the amblyopic eyes (r = -0.37, P = .022). The choroidal thickness in the peripapillary area was not significantly different in the three groups (P > .05). CONCLUSIONS: This study demonstrated that choroidal thickness can be measured by spectral-domain OCT in @entity1 with @entity4457 . Subfoveal @entity2194 was significantly thicker than in control eyes. The amblyopic process may involve the choroid, but not the macula. However, further evaluation is needed.

title: Analysis of Choroidal Thickness Using Spectral-Domain OCT in XXXX With Unilateral Amblyopia.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['choroidal thickness in amblyopic eyes', 'choroidal thickness of amblyopic and fellow eyes']

entities_list: @entity9340 :: ('MESH:D015858', 'Disease') :: ['anisometropia']

entities_list: @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal thickness measurement']

entities_list: @entity4457 :: ('MESH:D000550', 'Disease') :: ['amblyopia']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: OBJECTIVES: To analyze margin status and prognostic factors for complications in @entity1 undergoing vulvectomy for invasive @entity1544 (iSCC) with and without plastic-assisted closure. METHODS: Demographic and clinical data were collected on 94 @entity1 with iSCC who underwent vulvectomy between 2004 and 2013. All pathology slides were re-reviewed by two gynecologic pathologists. Data were analyzed using XLSTAT-Pro v2014.2.02. RESULTS: Of 88 eligible @entity1 , 15 (17%) had plastic-assisted vulvar closure and 73 (83%) did not. There were significantly more @entity1 in the plastics group with recurrent disease (53% v 10%) and history radiation therapy prior to surgery (40% versus 5%). Plastic-assisted closure was associated with larger @entity5 (3.73cm versus 2.03cm, p<0.01) and a higher frequency of adequate margins (53% versus 29%, p=0.06). For @entity5 >= 3.0cm, plastic-assisted closure was significantly associated with adequate margins (44% versus 6%, p=0.03). Prior radiation use was associated with plastic-assisted closure, larger @entity5 , older age, and recurrent disease. Complications occurred in 36 @entity1 (41%) and significantly more occurred in those with plastic-assisted closure (67% versus 36%, p=0.04). On multivariate analysis including age, @entity5 size, recurrent disease, plastic-assisted closure, and history of radiation, only history of radiation therapy was a significant predictor of complications (OR=17, 95%CI 2.05-141.35; p=0.01). CONCLUSIONS: Plastic-assisted vulvectomy closure was more often utilized in cases involving @entity5 . Plastic-assisted closure significantly increased the frequency of adequate margins in @entity5 >= 3cm and did not impact complications.

title: Does plastic surgical consultation improve the outcome of XXXX undergoing radical vulvectomy for squamous cell carcinoma of the vulva?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'past radiation therapy and larger tumors', 'tumors']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIMS: This study is to investigate the effect of amyloid b1-42 oligomers on insulin signaling in astrocytes. METHODS: Synthetic Ab1-42 oligomers were prepared and the oligomeric form of Ab1-42 was verified by an electron microscope. Normal @entity1 astrocytes were cultured in Dulbecco's Modified Eagle Medium. Western blotting was employed to measure the amount of lysate proteins. Immunofluorescence was performed to detect the distribution of phosphorylated @entity10175 and expression of P- @entity9459 in astrocytes under confocal microscopy and fluorescent microscopy, respectively. Periodic Acid-Schiff staining was used to detect glycogen, the content of which was measured using glycogen assay. RESULTS: Our data showed that Ab1-42 oligomers inhibited insulin-induced serine phosphorylation of Akt at 473 and @entity9459 at serine 9, as well as glycogen storage. However, the levels of phosphorylated @entity9459 at tyrosine 216 were significantly increased in the presence of Ab1-42 oligomers. In addition, the levels of phosphorylated @entity1366 and @entity10175 at serine 636/639 were significantly increased in response to treatment with Ab1-42 oligomers. Of note, the responses and inhibitory effects of Ab1-42 oligomers on insulin signaling were partially reversed by @entity1366 upstream inhibitor @entity4286 . CONCLUSIONS: Our results demonstrated that Ab1-42 oligomers impaired insulin signaling and suppressed insulin-induced glycogen storage in @entity1 astrocytes, probably due to @entity1366 -dependent serine phosphorylation of @entity10175 at 636/639 induced by Ab1-42 oligomers.

title: Amyloid b oligomer-induced XXXX -dependent serine 636/639 phosphorylation of @entity10175 impairs insulin signaling and glycogen storage in @entity1 astrocytes.

entities_list: @entity10175 :: ('3667', 'Gene') :: ['insulin receptor substrate-1']

answer: @entity1366 :: (5595;5594,Gene) :: ['ERK1/2']


abstract: AIMS: This study is to investigate the effect of amyloid b1-42 oligomers on insulin signaling in astrocytes. METHODS: Synthetic Ab1-42 oligomers were prepared and the oligomeric form of Ab1-42 was verified by an electron microscope. Normal @entity1 astrocytes were cultured in Dulbecco's Modified Eagle Medium. Western blotting was employed to measure the amount of lysate proteins. Immunofluorescence was performed to detect the distribution of phosphorylated @entity10175 and expression of P- @entity9459 in astrocytes under confocal microscopy and fluorescent microscopy, respectively. Periodic Acid-Schiff staining was used to detect glycogen, the content of which was measured using glycogen assay. RESULTS: Our data showed that Ab1-42 oligomers inhibited insulin-induced serine phosphorylation of Akt at 473 and @entity9459 at serine 9, as well as glycogen storage. However, the levels of phosphorylated @entity9459 at tyrosine 216 were significantly increased in the presence of Ab1-42 oligomers. In addition, the levels of phosphorylated @entity1366 and @entity10175 at serine 636/639 were significantly increased in response to treatment with Ab1-42 oligomers. Of note, the responses and inhibitory effects of Ab1-42 oligomers on insulin signaling were partially reversed by @entity1366 upstream inhibitor @entity4286 . CONCLUSIONS: Our results demonstrated that Ab1-42 oligomers impaired insulin signaling and suppressed insulin-induced glycogen storage in @entity1 astrocytes, probably due to @entity1366 -dependent serine phosphorylation of @entity10175 at 636/639 induced by Ab1-42 oligomers.

title: Amyloid b oligomer-induced @entity1366 -dependent serine 636/639 phosphorylation of XXXX impairs insulin signaling and glycogen storage in @entity1 astrocytes.

answer: @entity10175 :: (3667,Gene) :: ['insulin receptor substrate-1']


abstract: AIMS: This study is to investigate the effect of amyloid b1-42 oligomers on insulin signaling in astrocytes. METHODS: Synthetic Ab1-42 oligomers were prepared and the oligomeric form of Ab1-42 was verified by an electron microscope. Normal @entity1 astrocytes were cultured in Dulbecco's Modified Eagle Medium. Western blotting was employed to measure the amount of lysate proteins. Immunofluorescence was performed to detect the distribution of phosphorylated @entity10175 and expression of P- @entity9459 in astrocytes under confocal microscopy and fluorescent microscopy, respectively. Periodic Acid-Schiff staining was used to detect glycogen, the content of which was measured using glycogen assay. RESULTS: Our data showed that Ab1-42 oligomers inhibited insulin-induced serine phosphorylation of Akt at 473 and @entity9459 at serine 9, as well as glycogen storage. However, the levels of phosphorylated @entity9459 at tyrosine 216 were significantly increased in the presence of Ab1-42 oligomers. In addition, the levels of phosphorylated @entity1366 and @entity10175 at serine 636/639 were significantly increased in response to treatment with Ab1-42 oligomers. Of note, the responses and inhibitory effects of Ab1-42 oligomers on insulin signaling were partially reversed by @entity1366 upstream inhibitor @entity4286 . CONCLUSIONS: Our results demonstrated that Ab1-42 oligomers impaired insulin signaling and suppressed insulin-induced glycogen storage in @entity1 astrocytes, probably due to @entity1366 -dependent serine phosphorylation of @entity10175 at 636/639 induced by Ab1-42 oligomers.

title: Amyloid b oligomer-induced @entity1366 -dependent serine 636/639 phosphorylation of @entity10175 impairs insulin signaling and glycogen storage in XXXX astrocytes.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: INTRODUCTION: Recurrent @entity5 is common, costly, and lethal, yet we know little about it in community-based populations. Electronic health records and @entity5 registries contain vast amounts of data regarding community-based @entity1 , but usually lack recurrence status. Existing algorithms that use structured data to detect recurrence have limitations. METHODS: We developed algorithms to detect the presence and timing of recurrence after definitive therapy for stages I-III lung and @entity14 using 2 data sources that contain a widely available type of structured data (claims or electronic health record encounters) linked to gold-standard recurrence status: Medicare claims linked to the @entity5 Care Outcomes Research and Surveillance study, and the @entity5 Research Network Virtual Data Warehouse linked to registry data. Twelve potential indicators of recurrence were used to develop separate models for each @entity5 in each data source. Detection models maximized area under the ROC curve (AUC); timing models minimized average absolute error. Algorithms were compared by @entity5 type/data source, and contrasted with an existing binary detection rule. RESULTS: Detection model AUCs (>0.92) exceeded existing prediction rules. Timing models yielded absolute prediction errors that were small relative to follow-up time (<15%). Similar covariates were included in all detection and timing algorithms, though differences by @entity5 type and dataset challenged efforts to create 1 common algorithm for all scenarios. CONCLUSIONS: Valid and reliable detection of recurrence using big data is feasible. These tools will enable extensive, novel research on quality, effectiveness, and outcomes for lung and @entity14 @entity1 and those who develop recurrence.

title: Detecting Lung and XXXX Recurrence Using Structured Clinical/Administrative Data to Enable Outcomes Research and Population Health Management.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'Cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: BACKGROUND: @entity9282 ( @entity9282 ) is the third most common @entity853 . The efficacy of surgical treatment of neglected @entity9282 after skeletal maturity in adults remains controversial. The aim of this retrospective study was to determine the efficacy of arthroscopic release of the sternocleidomastoid (SCM) muscle for the treatment of neglected @entity9282 in adult cases. METHODS: From April 2008 to July 2013, a total of 20 adult @entity1 (9 @entity1 and 11 @entity1 ) with a mean age of 23.0 years were surgically treated for neglected @entity9282 with local anesthesia. The SCM muscle and clavicle were preoperatively marked. Through an artificial lacuna, an arthroscope and a radiofrequency probe were inserted. The sternal and clavicular attachments were dissected and divided via radiofrequency. Clinical evaluation was assessed using a modified Cheng and Tang score. RESULTS: The operation was successfully completed in all the @entity1 . Follow-up examinations from 12 to 40 months in the 20 @entity1 showed complete muscular release and satisfactory cosmetic appearance with no recurrence. There was no evidence of serious complications. The neck scars were no longer visible after several weeks. According to the modified Cheng and Tang scale, 11 @entity1 displayed an excellent result and 9 @entity1 had a good result. CONCLUSIONS: Arthroscopic release of the SCM muscle with local anesthesia is a simple and effective way to surgically manage neglected @entity9282 without any risk for either @entity75 or leaving visible scars.

title: Arthroscopic Surgical Treatment for Neglected XXXX in Adults.

entities_list: @entity853 :: ('MESH:D009139', 'Disease') :: ['congenital musculoskeletal anomaly']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity9282 :: ('MESH:C535425', 'Disease') :: ['CMT', 'Congenital muscular torticollis']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['damage to the neurovascular structures']

answer: @entity9282 :: (MESH:C535425,Disease) :: ['Congenital Muscular Torticollis']


abstract: UNASSIGNED: Higher serum level of @entity607 (PC) in @entity740 ( @entity740 ) @entity1 has been linked with @entity740 progression. The toxic effect of PC on diverse cells has been reported by prior studies, except for renal tubular cells. Both autophagy and apoptosis contribute to renal tubular cell death, yet evidence of its response to PC is limited and their crosstalk is still unclear. Autophagy is an important cellular process involved in toxin-induced cell death. @entity8 in @entity810 is thought to be one of the key events causing the progression of @entity740 . Thus, we treated @entity35 (NRK-52E) and @entity1 (HRPTEC) renal proximal tubular cells (RPTC) with PC and found the cell proliferation was significantly decreased. Cell apoptosis was significantly increased and accompanied with the activation of autophagy as evidenced by increases in LC3-II, @entity8783 and Atg 4. We also found an increase of @entity10407 by @entity1178 activation. @entity10407 accumulation could mediate the activation of @entity8186 -dependent cell apoptosis. Conversely, knockdown of @entity10407 by siRNA of @entity10407 had the opposite effect by arresting LC3-II accumulation and promoting increasing cell viability. We conclude that PC triggered autophagic RPTC death via JNK-mediated @entity10407 accumulation and then activated @entity8186 -dependent cell death pathway. PC can be considered as one of the key events causing progression of @entity740 , which might affect drug disposition in @entity740 cases.

title: XXXX mediates autophagic cell death in renal proximal tubular cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['Renal tubular cell death']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['tubular injury']

answer: @entity607 :: (MESH:C032538,Chemical) :: ['p-Cresol']


abstract: STUDY DESIGN.: Retrospective analysis of a prospectively collected single-center database. OBJECTIVE.: We describe a modified halo-gravity traction (HGT) protocol for @entity1 with severe @entity85 in @entity739 , and assess the clinical and radiographic outcomes. SUMMARY OF BACKGROUND DATA.: Three-column osteotomies are frequently used in the correction of severe @entity85 ; however, these can be associated with high complication rates and significant risk for @entity16 . Preoperative traction is one modality used to obtain a partial correction prior to definitive fusion. Low numbers and variability of traction protocols, however, have limited previous reports of sustained HGT. METHODS.: All @entity1 who underwent HGT in Ghana from April 2012 to August 2013 were reviewed. HGT was started at 20% body weight and increased by 10% per week until 50% body weight was reached by 4 weeks or thereafter as tolerated. Demographic variables, operative data, radiographic parameters, and health-related quality of life scores were collected. @entity85 reduction index was calculated at each time point by summing the scoliosis and abnormal @entity1513 for each @entity1 and reported as a percentage of the @entity85 . RESULTS.: Twenty-nine @entity1 underwent HGT for an average 107 days prior to definitive posterior spinal fusion (24 @entity1 ) or placement of growing rods (5 @entity1 ). The major curve improved from an average 131   to 90   (31%) after HGT, and to an average 57   (56%) postoperatively. Pure kyphotic curves were rigid (flexibility 22% after traction), with a correction index of 3.88, which is similar to historical controls. @entity85 with HGT plateaued at 63 days. Overall Scoliosis Research Society-22 questionnaire scores improved significantly pretraction versus postoperatively, but there was no change after traction versus before traction. There were 11 pin tract infections, with no @entity16 . CONCLUSION.: HGT is a safe method to partially correct severe @entity85 prior to a definitive procedure, and may reduce the need for higher risk 3-column osteotomies. Importantly, @entity1513 secondary to infection with spontaneous @entity661 is relatively resistant to HGT.Level of Evidence: 4.

title: Preoperative Halo-Gravity Traction for Severe XXXX at an SRS-GOP Site in @entity739 : Protocols, Complications, and Results.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological complications', 'neurological injury']

entities_list: @entity739 :: ('MESH:D013036', 'Disease') :: ['West Africa']

entities_list: @entity661 :: ('MESH:D054549', 'Disease') :: ['apical ankylosis']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['spinal deformities', 'Deformity correction', 'preoperative deformity', 'A deformity']

answer: @entity85 :: (MESH:D009140,Disease) :: ['Spinal Deformities']


abstract: STUDY DESIGN.: Retrospective analysis of a prospectively collected single-center database. OBJECTIVE.: We describe a modified halo-gravity traction (HGT) protocol for @entity1 with severe @entity85 in @entity739 , and assess the clinical and radiographic outcomes. SUMMARY OF BACKGROUND DATA.: Three-column osteotomies are frequently used in the correction of severe @entity85 ; however, these can be associated with high complication rates and significant risk for @entity16 . Preoperative traction is one modality used to obtain a partial correction prior to definitive fusion. Low numbers and variability of traction protocols, however, have limited previous reports of sustained HGT. METHODS.: All @entity1 who underwent HGT in Ghana from April 2012 to August 2013 were reviewed. HGT was started at 20% body weight and increased by 10% per week until 50% body weight was reached by 4 weeks or thereafter as tolerated. Demographic variables, operative data, radiographic parameters, and health-related quality of life scores were collected. @entity85 reduction index was calculated at each time point by summing the scoliosis and abnormal @entity1513 for each @entity1 and reported as a percentage of the @entity85 . RESULTS.: Twenty-nine @entity1 underwent HGT for an average 107 days prior to definitive posterior spinal fusion (24 @entity1 ) or placement of growing rods (5 @entity1 ). The major curve improved from an average 131   to 90   (31%) after HGT, and to an average 57   (56%) postoperatively. Pure kyphotic curves were rigid (flexibility 22% after traction), with a correction index of 3.88, which is similar to historical controls. @entity85 with HGT plateaued at 63 days. Overall Scoliosis Research Society-22 questionnaire scores improved significantly pretraction versus postoperatively, but there was no change after traction versus before traction. There were 11 pin tract infections, with no @entity16 . CONCLUSION.: HGT is a safe method to partially correct severe @entity85 prior to a definitive procedure, and may reduce the need for higher risk 3-column osteotomies. Importantly, @entity1513 secondary to infection with spontaneous @entity661 is relatively resistant to HGT.Level of Evidence: 4.

title: Preoperative Halo-Gravity Traction for Severe @entity85 at an SRS-GOP Site in XXXX : Protocols, Complications, and Results.

answer: @entity739 :: (MESH:D013036,Disease) :: ['West Africa']


abstract: @entity1072 ( @entity1072 ) is, in the great majority of cases, a neoplastic proliferation of B cells. The associated immunologic dysfunction accounts for many of the clinically associated phenomenon such as @entity281 and second @entity5 . Much of this dysfunction has been attributed to poor B-cell function. Functional impairment of the T-cell component is currently being elucidated. In the investigation of B cells. The associated immunologic dysfunction accounts for many of the clinically associated phenomenon such as @entity281 and second @entity5 . Much of this dysfunction has been attributed to poor B-cell function. Functional impairment of the T-cell component is currently being elucidated. In the investigation of B cells. The associated immunologic dysfunction accounts for many of the clinically associated phenomenon such as @entity281 and second @entity5 . Much of this dysfunction has been attributed to poor B-cell function. Functional impairment of the T-cell component is currently being elucidated. In the investigation of B cells. The associated immunologic dysfunction accounts for many of the clinically associated phenomenon such as @entity281 and second @entity5 . Much of this dysfunction has been attributed to poor B-cell function. Functional impairment of the T-cell component is currently being elucidated. In the investigation of B cells. The associated immunologic dysfunction accounts for many of the clinically associated phenomenon such as @entity281 and second @entity5 . Much of this dysfunction has been attributed to poor B-cell function. Functional impairment of the T-cell component is currently being elucidated. In the investigations reported herein, we further demonstrate the @entity3230 of @entity1072 by measuring proliferation and immunoglobulin synthesis in response to mitogens. Stimulation of various cell fractions indicates that in certain cases there is @entity1129 , while others T function appears intact. In 2 of 4 cases tested there was augmentation of ig synthesis when the @entity1072 cells were cocultured with thymic epithelium. The implications of such in vitro modulation are discussed.

title: Thymic dysfunction in XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity1072 :: ('MESH:D015451', 'Disease') :: ['CLL', 'Chronic lymphocytic leukemia']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1129 :: ('MESH:D001260', 'Disease') :: ['deficient T-helper']

entities_list: @entity3230 :: ('MESH:C565469', 'Disease') :: ['immune deficiency']

answer: @entity1072 :: (MESH:D015451,Disease) :: ['chronic lymphocytic leukemia']


abstract: PURPOSE: The concomitant use of @entity2995 (TA) at the completion of pars plana vitrectomy for the treatment of epiretinal membrane may speed up the anatomical and functional outcomes of surgery. We report the outcome of @entity1 undergoing small-gauge vitrectomy for @entity6654 with or without adjuvant TA therapy. DESIGN: This is a retrospective, single-center case series. METHODS: We included 75 eyes of 75 individual @entity1 . Twenty-six @entity1 (group A) had an adjuvant TA injection during surgery, whereas 49 @entity1 (group B) were not injected. We assessed the @entity1 for change in visual acuity (VA) and central macular thickness before and after surgery. RESULTS: Group A had a mean logarithm of the minimum angle of resolution VA of 0.63    0.33 and 0.51    0.31 preoperatively and 3 months after surgery, respectively. Group B had a mean logarithm of the minimum angle of resolution VA of 0.47    0.17 and 0.36    0.17 preoperatively and 3 months after surgery, respectively. No significant difference was found between the groups in change of VA. The mean central macular thickness for groups A and B @entity1 before surgery was 474.12    120  m and 445    85  m, decreasing to 369    70  m and 386    60  m at the final visit, respectively. The difference in macular thickness reduction between the groups was statistically significant. CONCLUSIONS: Anatomical and functional improvement was found in both groups after surgery. Macular thickness was further reduced in the group of @entity1 treated with adjuvant TA.

title: Role of Concomitant XXXX Injection in Small-Gauge Vitrectomy for Idiopathic @entity6654 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide']

entities_list: @entity6654 :: ('MESH:D019773', 'Disease') :: ['idiopathic epiretinal membrane peel']

answer: @entity2995 :: (MESH:D014222,Chemical) :: ['Triamcinolone Acetonide']


abstract: PURPOSE: The concomitant use of @entity2995 (TA) at the completion of pars plana vitrectomy for the treatment of epiretinal membrane may speed up the anatomical and functional outcomes of surgery. We report the outcome of @entity1 undergoing small-gauge vitrectomy for @entity6654 with or without adjuvant TA therapy. DESIGN: This is a retrospective, single-center case series. METHODS: We included 75 eyes of 75 individual @entity1 . Twenty-six @entity1 (group A) had an adjuvant TA injection during surgery, whereas 49 @entity1 (group B) were not injected. We assessed the @entity1 for change in visual acuity (VA) and central macular thickness before and after surgery. RESULTS: Group A had a mean logarithm of the minimum angle of resolution VA of 0.63    0.33 and 0.51    0.31 preoperatively and 3 months after surgery, respectively. Group B had a mean logarithm of the minimum angle of resolution VA of 0.47    0.17 and 0.36    0.17 preoperatively and 3 months after surgery, respectively. No significant difference was found between the groups in change of VA. The mean central macular thickness for groups A and B @entity1 before surgery was 474.12    120  m and 445    85  m, decreasing to 369    70  m and 386    60  m at the final visit, respectively. The difference in macular thickness reduction between the groups was statistically significant. CONCLUSIONS: Anatomical and functional improvement was found in both groups after surgery. Macular thickness was further reduced in the group of @entity1 treated with adjuvant TA.

title: Role of Concomitant @entity2995 Injection in Small-Gauge Vitrectomy for Idiopathic XXXX .

answer: @entity6654 :: (MESH:D019773,Disease) :: ['Epiretinal Membrane Peel']


abstract: AIM: To determine the number, distribution and cost of hospital admissions for @entity1030 ( @entity1030 ) in New Zealand. METHODS: National @entity1 -level routine data on admissions with a principal diagnosis of @entity1030 (mostly ICD-10- AN J440 and J441) were obtained for the period July 1st 2008 to June 30th 2013. Admissions with length of stay (LOS) = 90 days were excluded. RESULTS: There were 61,516 admissions in 5 years. Admission rates and budget impact (in 2012/13 dollar values) were stable but the average length of stay (ALOS) declined from 5.09 to 4.37 days. In FY2012/13 the admission rate was 2.82 per 1000 population, with age standardised rate (ASR) 4.4- and 3.6-fold higher for Maori and Pacific @entity1 respectively than for European/others. For age = 15 years the ASR was 2.55 per 1000. Admission rates were higher for @entity1 than @entity1 and increased steeply with age and socioeconomic deprivation (NZDep06). The mean age at discharge was lower for Maori and Pacific @entity1 than for European/Others (63.4, 67.1 and 72.3 years). The mean 30-day readmission rate was 6.7%. The average LOS increased with age and was shorter for Maori (3.6 days) and Pacific @entity1 (3.5 days) than for European/Others (4.7 days). Admission rates varied widely across District Health Boards, and were higher in rural than urban regions. The estimated cost of admissions in FY2012/13 was  NZ59.6m. CONCLUSIONS: Hospital admissions for @entity1030 are costly and are over-represented in high risk groups including rural, elderly, socioeconomically deprived and Maori and Pacific @entity1 . Effective interventions that are targeted to high risk groups are required to improve equity and reduce the burden of @entity1030 .

title: Hospital admissions for XXXX in New Zealand.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient', 'peoples', 'men']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

answer: @entity1030 :: (MESH:D029424,Disease) :: ['chronic obstructive pulmonary disease']


abstract: In 65 @entity748 @entity1 aged 18 to 59 years maximal expiratory flow-volume curves were performed. The measurements were done with a pneumotachograph in connection with a self-developed two-channel FM modulator, a stereo tape recorder, and a X-Y recorder. We examined 53 @entity1 in clinical remission and 12 @entity1 during an attack period. The greatest sensitivity of the tested flow-volume data had @entity16535 50/FVC pred. and the time constant of the terminal portion of the curve. @entity16535 50/ @entity16535 75 and V2/V1 were about equally sensitive for detecting ventilatory inhomogeneities. The attack group most differed from the remission groups in FVC % pred., @entity16535 50/FVC pred. and the other flow rates. The flow-volume curve is a valuable method to assess obstruction and ventilatory inhomogeneity in @entity748 @entity1 . It has a greater sensitivity than conventional spirometry.

title: [Results of the flow-volume curve in XXXX with bronchial asthma (author's transl)].

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Portulaca oleracea L. is an annual plant widely distributed from the temperate to the tropical zones. POL-P3b, a polysaccharide fraction purified from Portulaca oleracea L., is able to enhance immunity and inhibit @entity5 formation. Induction of antitumor immunity by @entity5 fusion cells can be modulated by their activation status. Mature dendritic cells are significantly better than immature dendritic cells at cytotoxic T-lymphocyte induction. In this study, we analyzed the effects of POL-P3b on the maturation and function of @entity19 bone-marrow-derived dendritic cells (DCs) and relevant mechanisms. The phenotypic maturation of DCs was confirmed by flow cytometry. We found that POL-P3b upregulated the expression of @entity8271 , @entity11787 , @entity19711 , and major histocompatibility complex class II molecules on DCs, stimulated production of more interleukin (IL)-12, @entity5 @entity39 factor-a, and less @entity1618 . Also, DCs pulsed POL-P3b and freeze-thaw antigen increased DCs-driven T cells' proliferation and promoted U14 cells' apoptosis. Furthermore, the expression of @entity1990 was significantly increased on DCs treated by POL-P3b. These results suggested that POL-P3b may induce DCs maturation through @entity1990 . Taken together, our results may have important implications for the molecular mechanisms of immunopotentiation of POL-P3b, and provide direct evidence to suggest that POL-P3b should be considered as a potent adjuvant nutrient supplement for DC-based vaccines.

title: Effects of Portulaca oleracea L. Polysaccharides on Phenotypic and Functional Maturation of XXXX Bone Marrow Derived Dendritic Cells.

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'dendritic-tumor']

answer: @entity19 :: (10090,Species) :: ['Murine']


abstract: BACKGROUND: We sought to evaluate the potential enhanced fibrinolytic and antiplatelet activity of @entity14534 (DE) due to decreased @entity556 levels in @entity1 with @entity64 or transient @entity63 attack and @entity955 ( @entity955 ). METHODS: Consecutive @entity1 with @entity66 and @entity955 that were treated with DE in a tertiary university hospital. Fibrinolysis and platelet function were assessed by thromboelastometry (ROTEM) and platelet function analyzer (PFA)-100, respectively, before and after treatment with DE. Conventional coagulation tests, endogenous @entity556 potential (ETP) and hemoclot @entity556 inhibitors (HTI), were also performed in order to detect any possible correlation between @entity3926 plasma levels, its anticoagulant activity and the intensity of @entity1423 or fibrinolysis. RESULTS: A total of nineteen @entity1 fulfilled our inclusion criteria (mean age 62.3  7.2years; 47% males; median CHADS2-score: 3; interquartile range: 2-4). DE treatment was associated with a significant reduction of the lysis index (LI60) at 60min (p=0.036), and prolongation of the PFA-100 CEPI closure time (p=0.024). After @entity3926 treatment, abnormal PFA-100 results were obtained in two @entity1 (11%, 95% CI: 2%-33%). DE levels (determined by HTI) were strongly inversely correlated (rho=-0.85; p<0.001) with the area under the curve (AUC) values in ETP assay.   o association was found between HTI and PFA-100 CEPI CT (p=0.64), or LI60 measurements (p=0.60). CONCLUSIONS: Our findings indicate that DE might affect platelet function and fibrinolysis and highlight the potential role of ETP as an alternative option in DE monitoring. The intensity and clinical relevance of DE antiplatelet and fibrinolytic effects require further investigation.

title: Impact of XXXX on platelet function and fibrinolysis.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular diseases']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet dysfunction']

entities_list: @entity3926 :: ('MESH:C554682', 'Chemical') :: ['dabigatran']

entities_list: @entity14534 :: ('MESH:C453962', 'Chemical') :: ['dabigatran etexilate']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['non-valvular atrial fibrillation', 'NVAF']

answer: @entity3926 :: (MESH:C554682,Chemical) :: ['dabigatran']


abstract: The current treatment for @entity1701 ( @entity1701 ) with @entity715 manifestation is long-term anticoagulation. @entity2067 antagonists (VKA) are usually the agents of choice. However, VKA limitations, such as unpredictable anticoagulation effects due to interaction with diet and other drugs, require regular monitoring. This may impact on @entity1 ' quality of life. Since the approval of new oral anticoagulants (NOAC) for non-valvular @entity955 and @entity1150 prevention, much has been speculated about its use in @entity1701 @entity1 . We report here a series of eight @entity1701 @entity1 with failure of @entity715 prevention during @entity3925 use. All @entity1 had @entity49 as the initial manifestation of @entity1701 , and two of them also had arterial manifestations. Three @entity1 had triple antibody positivity. Five @entity1 developed arterial events during the treatment with @entity3925 . Until the results of ongoing trials of @entity3925 for @entity1701 are presented, NOAC should not be recommended to @entity1701 @entity1 . Our preliminary experience as well cases previously reported in the literature suggest that there is a high-risk group that is less protected with @entity3925 , namely those with previous arterial @entity715 or triple positivity. VKA remains to be the mainstay treatment for @entity715 .

title: @entity715 events in patients with @entity1701 treated with XXXX : a series of eight cases.

entities_list: @entity2067 :: ('MESH:D014812', 'Chemical') :: ['Vitamin K']

entities_list: @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis']

entities_list: @entity1701 :: ('MESH:D016736', 'Disease') :: ['APS', 'antiphospholipid syndrome']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity3925 :: ('MESH:C503223', 'Chemical') :: ['rivaroxaban']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombotic APS', 'thrombosis', 'thrombotic']

answer: @entity3925 :: (MESH:C503223,Chemical) :: ['rivaroxaban']


abstract: The current treatment for @entity1701 ( @entity1701 ) with @entity715 manifestation is long-term anticoagulation. @entity2067 antagonists (VKA) are usually the agents of choice. However, VKA limitations, such as unpredictable anticoagulation effects due to interaction with diet and other drugs, require regular monitoring. This may impact on @entity1 ' quality of life. Since the approval of new oral anticoagulants (NOAC) for non-valvular @entity955 and @entity1150 prevention, much has been speculated about its use in @entity1701 @entity1 . We report here a series of eight @entity1701 @entity1 with failure of @entity715 prevention during @entity3925 use. All @entity1 had @entity49 as the initial manifestation of @entity1701 , and two of them also had arterial manifestations. Three @entity1 had triple antibody positivity. Five @entity1 developed arterial events during the treatment with @entity3925 . Until the results of ongoing trials of @entity3925 for @entity1701 are presented, NOAC should not be recommended to @entity1701 @entity1 . Our preliminary experience as well cases previously reported in the literature suggest that there is a high-risk group that is less protected with @entity3925 , namely those with previous arterial @entity715 or triple positivity. VKA remains to be the mainstay treatment for @entity715 .

title: @entity715 events in patients with XXXX treated with @entity3925 : a series of eight cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity1701 :: (MESH:D016736,Disease) :: ['antiphospholipid syndrome']


abstract: The current treatment for @entity1701 ( @entity1701 ) with @entity715 manifestation is long-term anticoagulation. @entity2067 antagonists (VKA) are usually the agents of choice. However, VKA limitations, such as unpredictable anticoagulation effects due to interaction with diet and other drugs, require regular monitoring. This may impact on @entity1 ' quality of life. Since the approval of new oral anticoagulants (NOAC) for non-valvular @entity955 and @entity1150 prevention, much has been speculated about its use in @entity1701 @entity1 . We report here a series of eight @entity1701 @entity1 with failure of @entity715 prevention during @entity3925 use. All @entity1 had @entity49 as the initial manifestation of @entity1701 , and two of them also had arterial manifestations. Three @entity1 had triple antibody positivity. Five @entity1 developed arterial events during the treatment with @entity3925 . Until the results of ongoing trials of @entity3925 for @entity1701 are presented, NOAC should not be recommended to @entity1701 @entity1 . Our preliminary experience as well cases previously reported in the literature suggest that there is a high-risk group that is less protected with @entity3925 , namely those with previous arterial @entity715 or triple positivity. VKA remains to be the mainstay treatment for @entity715 .

title: XXXX events in patients with @entity1701 treated with @entity3925 : a series of eight cases.

answer: @entity715 :: (MESH:D013927,Disease) :: ['Thrombotic']


abstract: BACKGROUND: Inpatient treatment of chronic complex @entity392 can be necessary for @entity1 with a high symptomatic strain, mostly accompanied by a corresponding mental comorbidity, and/or for @entity1 that can only perceive their psychogenic suffering through somatization into @entity392 . METHODS: We report the results of 368 consecutively treated inpatients with chronic complex @entity392 . @entity1 ' audiometric data were collected, and at the beginning and end of treatment, the Mini-Tinnitus Questionnaire (Mini-TQ12; Hiller und Goebel) was completed, as was the German version of the Hospitality Anxiety and @entity308 Score (HADS). Effect sizes were calculated for both questionnaires. Mean treatment duration was 38.8 days (standard deviation, SD: 13.6 days). The main therapeutic elements were intensive disorder-specific neurotologic counselling and psychoeducation; improvement of hearing by fitting of hearing aids, complemented by an individualized hearing therapy; and intensive individual and group-based psychotherapy. RESULTS: In addition to @entity392 , 82.1% of the @entity1 had reduced hearing requiring rehabilitation with hearing aids. After hospitalization, a highly significant improvement in @entity392 could be demonstrated by the Mini-TQ12. Furthermore, a significant @entity308 and @entity148 components of HADS was also achieved, with high effect sizes of 1.6 to 2.2. No @entity304 to a medium- or low-range level was experienced by 8.9% of @entity1 . CONCLUSION: With corresponding symptomatic suffering, @entity74 neurotologic and psychosomatic alignment can achieve medium- to high-range therapeutic effects.

title: [Pre- and posttreatment results of an inpatient neurotologic and psychosomatic XXXX therapy].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'reduction in the depression']

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['reduction of tinnitus symptoms']

entities_list: @entity392 :: ('MESH:D014012', 'Disease') :: ['tinnitus', 'tinnitus strain']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['disorder-specific inpatient tinnitus treatment comprising']

answer: @entity392 :: (MESH:D014012,Disease) :: ['tinnitus']


abstract: BACKGROUND: @entity1 with @entity14 are often excluded from clinical trials based on age or a poor performance score. However, 70% of @entity14 is diagnosed in @entity1 over 65. Evaluation on the influence of age and comorbidity on survival and cause of @entity204 in a non-selected population. METHODS: Included were 621 consecutive @entity1 with @entity14 . An extensive chart review was performed for 392 @entity1 with @entity694 and 143 @entity1 with @entity5 . Analyses were performed separately for both groups. RESULTS: Median survival of @entity694 @entity1 was 5.13 years, 131 @entity1 (34.3%) died from @entity5 progression. Age and comorbidity were significant predictors for overall survival (P<0.001). Age was also a significant predictor of cause of @entity204 (P=0.001). In @entity5 @entity1 median survival was 4.67 years, 51 (35.7%) of @entity1 died from @entity5 progression. Neither age nor comorbidity was significant predictors of survival. Age was a significant predictor of cause of @entity204 (P<0.001). CONCLUSIONS: In @entity694 @entity1 age and comorbidity predict survival. This represents possible bias or a reduced survival benefit of treatment, and is an indication that @entity694 is not the prognosis defining illness in the majority of @entity1 . In @entity5 @entity1 neither age or comorbidity significantly impacted survival.

title: Impact of age and comorbidity on survival in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer', 'tumour']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: BACKGROUND: The goal of surgery for @entity14 is cure. Unfortunately post-operative mortality occurs. This study aims to identify co-morbidity and causes of mortality in the post-operative period in relation to direct technical complications of surgery. METHODS: All consecutive @entity1 who underwent surgery for @entity14 were included. Co-morbidity was determined via the Charlson co-morbidity score. The post-operative course was studied and cause of @entity204 within 30 days was determined. @entity1 were divided in two groups: group 1 died within 30 days after surgery and group 2 survived for longer than 30 days. RESULTS: Twenty three out of 333 @entity1 (6.9%) with @entity694 and 6 out of 112 (5.3%) with @entity5 died in the post-operative period. @entity1 in group 1 were significantly older than @entity1 in group 2 (P<0.001). @entity1 in group 1 with @entity694 also significantly had more often a higher stage of @entity5 (P=0.03). The Charlson co-morbidity score for @entity1 with @entity694 in group 1 was mean 5.17 (SD 1.57, range, 1-8), and for @entity5 mean 4.83 (SD 2.32, range, 2-7). There was no difference in Charlson co-morbidity score when @entity1 from groups 1 and 2 were compared. In group 1, 13 (44%) died as a direct consequence of technical surgical complications. Sixteen @entity1 died due to complications because of pre-existing co-morbidity. CONCLUSIONS: Post-operative mortality very often is the direct result of pre-existing co-morbidity and not always the direct result of the surgical procedure.

title: Thirty days post-operative mortality after surgery for XXXX : a descriptive study.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'rectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: Purpose/Aim of the Study. Subthreshold micropulse diode laser photocoagulation is an effective treatment for @entity1103 . The molecular mechanisms underlying treatment success are poorly understood. Therefore, we investigated the effects of sublethal laser energy doses on a single layer of densely cultured @entity1 cells as a model of the @entity1 @entity989 ( @entity989 ). Materials and Methods. A single layer of densely cultured @entity1 @entity1 cells was perpendicularly irradiated with a micropulse diode laser. Nonirradiated cells served as controls. Sublethal laser energy was applied to form a photocoagulation-like area in the cultured cell layers. @entity2285 expression was evaluated using quantitative polymerase chain reaction and immunocytochemistry. Results. Photocoagulation-like areas were successfully created in cultured @entity1 cell layers using sublethal laser energy with our laser irradiation system. @entity2285 mRNA expression in cell layers was induced within 30   min of laser irradiation, peaking at 3   h after irradiation. This increase was dependent on the number of laser pulses. @entity2285 upregulation was not observed in untreated cell layers. Immunostaining indicated that @entity2285 expression occurred concentrically around laser irradiation sites and persisted for 24   h following irradiation. Conclusion. Sublethal photothermal stimulation with a micropulse laser may facilitate @entity2285 expression in the @entity989 without inducing cellular damage.

title: Sublethal Photothermal Stimulation with a Micropulse Laser Induces Heat Shock Protein Expression in XXXX Cells.

entities_list: @entity1103 :: ('MESH:D008269', 'Disease') :: ['macular edema']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'RPE']

answer: @entity1 :: (9606,Species) :: ['ARPE-19']


abstract: The aim of this study was to discuss the effect of autogenic training (AT) on @entity1 with @entity2531 ( @entity2531 ) using salivary amylase, the skin temperature of the finger, subjective severity of symptoms, and psychological characteristics as measures. We assessed 20 @entity1 with @entity2531 and 23 healthy controls before and after AT. Baseline levels of salivary amylase prior to an AT session were significantly higher in the @entity2531 group than in the control group. However, this difference was not significant after AT. The skin temperature of the finger increased after AT in both the @entity2531 and control groups. AT contributed to the improvement of somatic symptoms in @entity1 with @entity2531 . Our results regarding psychological characteristics suggest that @entity1316 are deeply involved in the pathology of @entity2531 . Individuals with @entity2531 exhibited elevated levels of sympathetic activity compared with healthy controls. Our data indicates that AT eased dysregulation of the autonomic nervous system in @entity1 with @entity2531 . Thus, salivary amylase may be a useful index of change induced by AT in @entity1 with @entity2531 .

title: Saliva amylase as a measure of sympathetic change elicited by autogenic training in XXXX with functional somatic syndromes.

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disturbances']

entities_list: @entity2531 :: ('MESH:D013001', 'Disease') :: ['functional somatic syndrome', 'FSS']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Background and Aims. It is widely accepted that @entity27 ( @entity27 ) is independently associated with @entity731 . Similar to @entity27 , @entity101 ( @entity101 ) is a condition associated with @entity731 . However, to date, the impact of the simultaneous presence of @entity27 and @entity101 on the risk of @entity731 has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of @entity27 and @entity101 on carotid @entity121 ( @entity121 ) and on inflammatory markers of @entity731 (such as interleukin- [IL-] 6 and pentraxin- [ @entity4045 -] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n = 30); (2) @entity27 @entity1 without @entity101 (n = 30); (3) @entity101 @entity1 without @entity27 (n = 30); (4) @entity1 with @entity27 and @entity101 (n = 30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid @entity121 was measured. Results. Carotid @entity121 , @entity650 , and @entity40590 in @entity27 normotensive @entity1 and in non- @entity27 @entity101 subjects were significantly higher compared to control subjects; in addition, in @entity27 @entity101 @entity1 they were significantly increased compared to @entity27 normotensive, non- @entity27 @entity101 , or control subjects. Conclusions. @entity27 and @entity101 have an additive role in the progression of @entity2998 and in blood levels of inflammatory markers for @entity731 , such as @entity650 and @entity40590 .

title: Obstructive Sleep Apnea, XXXX , and Their Additive Effects on @entity731 .

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'HTN', 'hypertensive']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['IMT', 'intima-media thickness']

answer: @entity101 :: (MESH:D006973,Disease) :: ['Hypertension']


abstract: Background and Aims. It is widely accepted that @entity27 ( @entity27 ) is independently associated with @entity731 . Similar to @entity27 , @entity101 ( @entity101 ) is a condition associated with @entity731 . However, to date, the impact of the simultaneous presence of @entity27 and @entity101 on the risk of @entity731 has not been extensively studied. The aim of this study was to evaluate the consequences of the coexistence of @entity27 and @entity101 on carotid @entity121 ( @entity121 ) and on inflammatory markers of @entity731 (such as interleukin- [IL-] 6 and pentraxin- [ @entity4045 -] 3). Methods. The study design allowed us to define 4 groups: (1) controls (n = 30); (2) @entity27 @entity1 without @entity101 (n = 30); (3) @entity101 @entity1 without @entity27 (n = 30); (4) @entity1 with @entity27 and @entity101 (n = 30). In the morning after portable monitoring (between 7 am and 8 am), blood samples were collected, and carotid @entity121 was measured. Results. Carotid @entity121 , @entity650 , and @entity40590 in @entity27 normotensive @entity1 and in non- @entity27 @entity101 subjects were significantly higher compared to control subjects; in addition, in @entity27 @entity101 @entity1 they were significantly increased compared to @entity27 normotensive, non- @entity27 @entity101 , or control subjects. Conclusions. @entity27 and @entity101 have an additive role in the progression of @entity2998 and in blood levels of inflammatory markers for @entity731 , such as @entity650 and @entity40590 .

title: Obstructive Sleep Apnea, @entity101 , and Their Additive Effects on XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']