abstract: INTRODUCTION: To date, no study has compared laparoscopy (LB) to percutaneous (PB) biopsy for the diagnosis of @entity706 . The objective of this study is to compare the success rate and safety profile of laparoscopic lymph node biopsy to the percutaneous approach in @entity1 with intra-abdominal lymphadenopathy concerning for @entity706 . MATERIALS AND METHODS: We performed a multi-institution, retrospective review of @entity1 undergoing lymph node biopsy for suspected @entity706 between 2005 and 2013. Our primary outcome was adequate tissue yield between the two techniques, both for histologic diagnosis and for ancillary studies such as flow cytometry. Secondary outcomes included 30-day morbidity, 30-day readmission rates, the need for additional lymph node biopsy procedures, and length of stay. RESULTS: All 34 of the LB @entity1 had adequate specimen for histologic diagnosis compared to 92.3  % of @entity1 with a PB (p  =  0.18). Significantly more @entity1 in the LB group had sufficient tissue for ancillary studies when needed than in the PB group, 95.5 and 68.2  %, respectively (p  =  0.04). A second biopsy was pursued in 23.1  % of failed PB @entity1 , 0  % with success on second attempt. DISCUSSION: When index of suspicion is high or when biopsy is performed for @entity1 previously diagnosed with @entity706 and recurrence/transformation is suspected, LB safely and consistently provides adequate tissue for initial diagnosis and for ancillary studies. In contrast, image-guided PB may be more appropriate for @entity1 for whom ancillary studies are unlikely to add to planned treatments or when there is a high risk of complications from either general anesthesia or @entity1 comorbidities.

title: Laparoscopy has a superior diagnostic yield than percutaneous image-guided biopsy for suspected XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'intra-abdominal lymphoma', 'abdominal lymphoma']

answer: @entity706 :: (MESH:D008223,Disease) :: ['intra-abdominal lymphoma']


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity1727 ( @entity1727 ) and @entity1152 ( @entity1152 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity1 with admission age<three days and ICD-9 diagnostic classification of @entity1152 or @entity1727 or procedural coding for @entity1727 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity299 (major and minor), and chromosomal, other @entity344 , and @entity8 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity1 at high, intermediate, and low risk of @entity204 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity204 . The model can be summarized as follows with @entity1 first assigned a score for associated abnormalities: @entity2008 =6 points, major @entity299 =3 points, @entity8 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity1 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for @entity1152 ( @entity1152 ) and XXXX ( @entity1727 ).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal anomalies', 'renal anomaly']

entities_list: @entity1152 :: ('MESH:D004933', 'Disease') :: ['esophageal atresia', 'EA']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal, central nervous system']

entities_list: @entity1727 :: ('MESH:D004937', 'Disease') :: ['TEF', 'tracheo-esophageal fistula']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac anomaly', 'cardiac anomalies']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['chromosomal abnormality']

answer: @entity1727 :: (MESH:D004937,Disease) :: ['tracheo-esophageal fistula']


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity1727 ( @entity1727 ) and @entity1152 ( @entity1152 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity1 with admission age<three days and ICD-9 diagnostic classification of @entity1152 or @entity1727 or procedural coding for @entity1727 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity299 (major and minor), and chromosomal, other @entity344 , and @entity8 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity1 at high, intermediate, and low risk of @entity204 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity204 . The model can be summarized as follows with @entity1 first assigned a score for associated abnormalities: @entity2008 =6 points, major @entity299 =3 points, @entity8 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity1 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for @entity1152 ( @entity1152 ) and @entity1727 ( XXXX ).

answer: @entity1727 :: (MESH:D004937,Disease) :: ['TEF']


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity1727 ( @entity1727 ) and @entity1152 ( @entity1152 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity1 with admission age<three days and ICD-9 diagnostic classification of @entity1152 or @entity1727 or procedural coding for @entity1727 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity299 (major and minor), and chromosomal, other @entity344 , and @entity8 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity1 at high, intermediate, and low risk of @entity204 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity204 . The model can be summarized as follows with @entity1 first assigned a score for associated abnormalities: @entity2008 =6 points, major @entity299 =3 points, @entity8 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity1 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for XXXX ( @entity1152 ) and @entity1727 ( @entity1727 ).

answer: @entity1152 :: (MESH:D004933,Disease) :: ['esophageal atresia']


abstract: BACKGROUND/PURPOSE: Existing prediction models for @entity1727 ( @entity1727 ) and @entity1152 ( @entity1152 ) are derived from small single-institution populations treated over long periods. A prediction rule developed in a contemporary, multicenter cohort is important for counseling, tailoring therapy, and benchmarking outcomes. METHODS: Data were obtained from the 2003, 2006, and 2009 editions of the HCUP Kids' Inpatient Database. Subjects included @entity1 with admission age<three days and ICD-9 diagnostic classification of @entity1152 or @entity1727 or procedural coding for @entity1727 repair. An internally validated prediction rule for survival to discharge was developed using a stepwise logistic regression selection algorithm. Predictors included were sex, birth weight, gestational age, @entity299 (major and minor), and chromosomal, other @entity344 , and @entity8 . The model was evaluated for discrimination and calibration and compared with that of Spitz. RESULTS: An integer-based prediction model was created, identifying @entity1 at high, intermediate, and low risk of @entity204 with very good discrimination (c=0.723) and calibration. It is particularly effective at identifying the small population at highest risk of @entity204 . The model can be summarized as follows with @entity1 first assigned a score for associated abnormalities: @entity2008 =6 points, major @entity299 =3 points, @entity8 =2 points, and weight less than 1500g=9 points. Point score cut-offs were 0-6 points low risk, 7-14 intermediate risk, and 15-20 high risk. CONCLUSIONS: This model compares well with existing prediction models and more effectively discriminates the highest risk @entity1 who may require tailored therapy. The Spitz model is also validated.

title: A contemporary prediction rule for @entity1152 ( XXXX ) and @entity1727 ( @entity1727 ).

answer: @entity1152 :: (MESH:D004933,Disease) :: ['EA']


abstract: UNASSIGNED: Introduction: Cervical vertebral (C) @entity600 is rarely reported in large breed @entity235 . @entity3799 ( @entity3799 ) may result from defects of @entity1347 , failure of formation or both. This report describes two cases of C3-C4 @entity3799 in young sighthounds, treated surgically. Case description: An 18-month-old female Deerhound and a six-week-old female Borzoi @entity235 were presented because of the complaints of reluctance to exercise and signs of of @entity4048 . Both @entity235 were neurologically normal. Diagnostic imaging revealed @entity85 , moderate @entity1513 , and spinal canal stenosis associated with chronic spinal cord pressure @entity194 . Both @entity235 underwent surgical treatment. Results: A staged two-step surgery starting with dorsal decompression was elected in the Deerhound. After the first surgical procedure, the @entity235 developed focal myelomalacia and @entity2895 and was euthanatized. A ventral distraction-fusion technique with two locking plates was performed in the Borzoi. This @entity1 recovered uneventfully and long-term follow-up computed tomography revealed complete spondylodesis. Clinical significance: Until now, @entity3799 has only been described in sighthounds. @entity3799 might be considered a differential diagnosis in these breeds that are presented with signs of @entity158 . Ventral realignment-fusion and bone grafting may be considered for surgical treatment, although the earliest age at which this procedure can and should be performed remains unclear.

title: XXXX in two young sighthounds.

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['vertebral segmentation']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformation']

entities_list: @entity2895 :: ('MESH:D015840', 'Disease') :: ['phrenic nerve paralysis']

entities_list: @entity3799 :: ('MESH:D002575', 'Disease') :: ['CCK', 'Congenital cervical kyphosis']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['cervical pain']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['C3-C4 deformity']

answer: @entity3799 :: (MESH:D002575,Disease) :: ['Congenital cervical kyphosis']


abstract: BACKGROUND: This study examined the prevalence and treatment of 17 co-occurring physical health conditions among adults with serious @entity146 , and factors associated with prevalence of the 5 most common medical co-morbidities. METHODS: Data were collected from 457 adults attending publicly funded mental health programs who participated in community health screenings held in 4 U.S. states. Face-to-face interviews included standardized items from the National Health Interview Survey and the National Health and Nutrition Examination Survey. Ordinary least squares regression analysis examined associations between prevalence of the 5 most common co-morbid conditions and respondents' demographic, clinical, attitudinal, and health insurance statuses. RESULTS: Compared to the U.S. population, prevalence was significantly higher for 14 out of 17 medical conditions assessed. The 5 most common were @entity407 (45%), @entity101 (44%), @entity565 (28%), @entity625 (22%), and @entity6 (21%). Controlling for age, study site, and Medicaid status, racial/ethnic minorities were almost twice as likely as Caucasians to be diagnosed with @entity101 and @entity6 ; @entity1 were almost twice as likely as @entity1 to be diagnosed with @entity6 ; and @entity1 with @entity161 were around half as likely as those with other disorders to be diagnosed with @entity101 and @entity625 . Age was positively related to all conditions except @entity565 . Treatment prevalence was below 70% for approximately half of ongoing conditions. CONCLUSIONS: These results suggest a high level of medical vulnerability and need for coordination of health and mental health services in this population. Associations with age, minority status, and gender point to the need for targeted health care strategies.

title: Factors associated with co-occurring medical conditions among adults with serious XXXX .

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'people', 'men']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental health disorders']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity146 :: (MESH:D001523,Disease) :: ['mental disorders']


abstract: @entity734 ( @entity734 ) are widely used in @entity1 and adolescents to treat a variety of @entity146 . However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent @entity35 with @entity1037 (OLA; a widely prescribed AAPD) on postnatal days 28-49, under dosing conditions that approximate those employed therapeutically in @entity1 , causes long-term behavioral and neurobiological perturbations. We have begun to study the mechanisms of these effects. @entity935 (DA) and @entity750 (5HT) regulate many neurodevelopmental processes. Currently approved @entity734 exert their therapeutic effects principally through their DAergic activities, although in @entity161 ( @entity161 ) and some other diseases for which @entity734 are prescribed, @entity409 is accompanied by @entity854 (GLUergic) and y-aminobutyric acidergic (GABAergic) transmission. Here, we use proton magnetic resonance spectroscopy ((1)H MRS) to investigate the effects of adolescent OLA administration on @entity1246 and @entity367 levels. We found that the treatment caused long-term reductions in the levels of both @entity367 and @entity1246 in the nucleus accumbens (NAc) of adult @entity35 treated with OLA during adolescence. The NAc is a key node in the brain's "reward" system, whose function is also disrupted in @entity161 . Further research into potential, OLA-induced changes in the levels of @entity367 and @entity1246 in the NAc and other brain areas, and the dynamics and mechanisms of those changes, are an essential step for devising new adjunct therapies for existing @entity734 and for designing new drugs that increase therapeutic effects and reduce long-term abnormalities when administered to pediatric @entity1 .

title: XXXX antipsychotic treatment of adolescent @entity35 causes long term changes in glutamate and @entity1246 levels in the nucleus accumbens.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'humans', 'patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders']

entities_list: @entity935 :: ('MESH:D004298', 'Chemical') :: ['Dopamine']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['DAergic dysfunction']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormalities of glutamatergic']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'SZ']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

entities_list: @entity1037 :: ('MESH:C076029', 'Chemical') :: ['olanzapine']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['Atypical antipsychotic drugs', 'AAPDs']

answer: @entity1037 :: (MESH:C076029,Chemical) :: ['Olanzapine']


abstract: @entity734 ( @entity734 ) are widely used in @entity1 and adolescents to treat a variety of @entity146 . However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent @entity35 with @entity1037 (OLA; a widely prescribed AAPD) on postnatal days 28-49, under dosing conditions that approximate those employed therapeutically in @entity1 , causes long-term behavioral and neurobiological perturbations. We have begun to study the mechanisms of these effects. @entity935 (DA) and @entity750 (5HT) regulate many neurodevelopmental processes. Currently approved @entity734 exert their therapeutic effects principally through their DAergic activities, although in @entity161 ( @entity161 ) and some other diseases for which @entity734 are prescribed, @entity409 is accompanied by @entity854 (GLUergic) and y-aminobutyric acidergic (GABAergic) transmission. Here, we use proton magnetic resonance spectroscopy ((1)H MRS) to investigate the effects of adolescent OLA administration on @entity1246 and @entity367 levels. We found that the treatment caused long-term reductions in the levels of both @entity367 and @entity1246 in the nucleus accumbens (NAc) of adult @entity35 treated with OLA during adolescence. The NAc is a key node in the brain's "reward" system, whose function is also disrupted in @entity161 . Further research into potential, OLA-induced changes in the levels of @entity367 and @entity1246 in the NAc and other brain areas, and the dynamics and mechanisms of those changes, are an essential step for devising new adjunct therapies for existing @entity734 and for designing new drugs that increase therapeutic effects and reduce long-term abnormalities when administered to pediatric @entity1 .

title: @entity1037 antipsychotic treatment of adolescent @entity35 causes long term changes in glutamate and XXXX levels in the nucleus accumbens.

answer: @entity1246 :: (MESH:D005680,Chemical) :: ['GABA']


abstract: @entity734 ( @entity734 ) are widely used in @entity1 and adolescents to treat a variety of @entity146 . However, little is known about the long-term effects of AAPD treatment before the brain is fully developed. Indeed, we and others have previously reported that treatment of adolescent @entity35 with @entity1037 (OLA; a widely prescribed AAPD) on postnatal days 28-49, under dosing conditions that approximate those employed therapeutically in @entity1 , causes long-term behavioral and neurobiological perturbations. We have begun to study the mechanisms of these effects. @entity935 (DA) and @entity750 (5HT) regulate many neurodevelopmental processes. Currently approved @entity734 exert their therapeutic effects principally through their DAergic activities, although in @entity161 ( @entity161 ) and some other diseases for which @entity734 are prescribed, @entity409 is accompanied by @entity854 (GLUergic) and y-aminobutyric acidergic (GABAergic) transmission. Here, we use proton magnetic resonance spectroscopy ((1)H MRS) to investigate the effects of adolescent OLA administration on @entity1246 and @entity367 levels. We found that the treatment caused long-term reductions in the levels of both @entity367 and @entity1246 in the nucleus accumbens (NAc) of adult @entity35 treated with OLA during adolescence. The NAc is a key node in the brain's "reward" system, whose function is also disrupted in @entity161 . Further research into potential, OLA-induced changes in the levels of @entity367 and @entity1246 in the NAc and other brain areas, and the dynamics and mechanisms of those changes, are an essential step for devising new adjunct therapies for existing @entity734 and for designing new drugs that increase therapeutic effects and reduce long-term abnormalities when administered to pediatric @entity1 .

title: @entity1037 antipsychotic treatment of adolescent XXXX causes long term changes in glutamate and @entity1246 levels in the nucleus accumbens.

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND: @entity24154 ( @entity24154 ) is a transactivator of transcription of @entity1 c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very low background. @entity24154 is abundantly expressed in the majority of @entity96 and has been implicated in @entity5 development. Although it down-regulates the expression of proapoptotic @entity3544 protein, it is not known whether @entity24154 also interacts and antagonizes the function of @entity5 suppressor protein @entity876 . METHODS: Western blotting was carried out to detect the expression level of @entity24154 , @entity3544 and @entity876 , and also @entity876 regulatory factors, @entity71799 and @entity13676 ; real-time quantitative PCR was done to determine the fold change in mRNA levels of target proteins; immunoprecipitation was carried out to determine the interaction of @entity24154 with @entity876 , @entity71799 and @entity13676 . Cells stably knockdown for either @entity24154 ; @entity876 or @entity71799 were examined for @entity876 reporter activity under normal and radiation-induced stress. RESULTS: @entity24154 physically interacted with @entity876 , impairing its transcription activity and reducing @entity876 -mediated sensitivity to cellular stress. Knockdown of @entity24154 expression activated @entity876 -mediated response to cellular stress while transient expression of @entity24154 in @entity24154 -knockdown cells restored the inhibition of @entity876 activity. @entity24154 not only interacted with both @entity71799 and @entity13676 , which, respectively, function as positive and negative regulators of @entity876 , but also regulated their expression under cellular stress. In @entity24154 knockdown cells, @entity13676 expression was down-regulated under radiation-induced stress whereas expression of @entity71799 and @entity3544 were significantly up-regulated suggesting @entity24154 as a potential regulator of these proteins. We hypothesize that the @entity24154 -mediated suppression of @entity876 activity may occur via preventing the interaction of @entity876 with @entity71799 as well as by @entity24154 -mediated regulation of @entity876 regulatory proteins, @entity13676 and @entity71799 . Since @entity24154 suppresses @entity876 activity and is overexpressed in most @entity5 , it may have a possible role in tumorigenesis. CONCLUSION: @entity24154 physically interacts with @entity876 , functions as a regulator of @entity876 -regulatory proteins ( @entity13676 and @entity71799 ), and suppresses @entity876 transactivation activity under radiation-induced cellular stress. Since it is abundantly expressed in most @entity5 , it may have implication in tumorigenesis and thus may be a possible target for drug development.

title: Fuse binding protein antagonizes the transcription activity of @entity5 suppressor protein XXXX .

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['hepatocellular carcinoma tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'HCC tumors']

entities_list: @entity24154 :: ('2203', 'Gene') :: ['FBP', 'FUSE binding protein1', 'FBP1']

answer: @entity876 :: (7157,Gene) :: ['p53']


abstract: BACKGROUND: @entity24154 ( @entity24154 ) is a transactivator of transcription of @entity1 c-myc proto-oncogene and expressed mainly in undifferentiated cells. It is also present in differentiated normal cells albeit with very low background. @entity24154 is abundantly expressed in the majority of @entity96 and has been implicated in @entity5 development. Although it down-regulates the expression of proapoptotic @entity3544 protein, it is not known whether @entity24154 also interacts and antagonizes the function of @entity5 suppressor protein @entity876 . METHODS: Western blotting was carried out to detect the expression level of @entity24154 , @entity3544 and @entity876 , and also @entity876 regulatory factors, @entity71799 and @entity13676 ; real-time quantitative PCR was done to determine the fold change in mRNA levels of target proteins; immunoprecipitation was carried out to determine the interaction of @entity24154 with @entity876 , @entity71799 and @entity13676 . Cells stably knockdown for either @entity24154 ; @entity876 or @entity71799 were examined for @entity876 reporter activity under normal and radiation-induced stress. RESULTS: @entity24154 physically interacted with @entity876 , impairing its transcription activity and reducing @entity876 -mediated sensitivity to cellular stress. Knockdown of @entity24154 expression activated @entity876 -mediated response to cellular stress while transient expression of @entity24154 in @entity24154 -knockdown cells restored the inhibition of @entity876 activity. @entity24154 not only interacted with both @entity71799 and @entity13676 , which, respectively, function as positive and negative regulators of @entity876 , but also regulated their expression under cellular stress. In @entity24154 knockdown cells, @entity13676 expression was down-regulated under radiation-induced stress whereas expression of @entity71799 and @entity3544 were significantly up-regulated suggesting @entity24154 as a potential regulator of these proteins. We hypothesize that the @entity24154 -mediated suppression of @entity876 activity may occur via preventing the interaction of @entity876 with @entity71799 as well as by @entity24154 -mediated regulation of @entity876 regulatory proteins, @entity13676 and @entity71799 . Since @entity24154 suppresses @entity876 activity and is overexpressed in most @entity5 , it may have a possible role in tumorigenesis. CONCLUSION: @entity24154 physically interacts with @entity876 , functions as a regulator of @entity876 -regulatory proteins ( @entity13676 and @entity71799 ), and suppresses @entity876 transactivation activity under radiation-induced cellular stress. Since it is abundantly expressed in most @entity5 , it may have implication in tumorigenesis and thus may be a possible target for drug development.

title: Fuse binding protein antagonizes the transcription activity of XXXX suppressor protein @entity876 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: @entity28 is prevalent worldwide, and is highly associated with @entity209 , such as insulin resistance, @entity407 and @entity1560 . @entity9052 has been used as food and traditional herbal medicine for the treatment of various @entity209 . However, the molecular mechanisms how @entity9052 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity71800 ( @entity3445 ), a major @entity9052 constituent, inhibited @entity6170 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity28 (DIO) @entity19 , @entity3445 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity1560 , in the livers. These effects were confirmed with genetically @entity28 ob/ob @entity19 . A reporter gene assay showed that @entity3445 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity3445 was specifically bound to PPARy @entity21244 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity3445 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity28 and @entity1560 . Our findings shed new light on the mechanism of @entity9052 in the treatment of @entity209 .

title: XXXX , a novel PPARy antagonist from @entity9052 , alleviates @entity1560 in @entity19 .

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['particular macrovesicular steatosis', 'steatosis']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['Obesity', 'obesity', 'obese']

entities_list: @entity71800 :: ('MESH:C081552', 'Chemical') :: ['protopanaxatriol']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic diseases', 'metabolic syndrome', 'metabolic disorders']

entities_list: @entity9052 :: ('4054', 'Species') :: ['Ginseng', 'ginseng']

entities_list: @entity6170 :: ('MESH:C089730', 'Chemical') :: ['rosiglitazone']

answer: @entity71800 :: (MESH:C081552,Chemical) :: ['Protopanaxatriol']


abstract: @entity28 is prevalent worldwide, and is highly associated with @entity209 , such as insulin resistance, @entity407 and @entity1560 . @entity9052 has been used as food and traditional herbal medicine for the treatment of various @entity209 . However, the molecular mechanisms how @entity9052 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity71800 ( @entity3445 ), a major @entity9052 constituent, inhibited @entity6170 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity28 (DIO) @entity19 , @entity3445 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity1560 , in the livers. These effects were confirmed with genetically @entity28 ob/ob @entity19 . A reporter gene assay showed that @entity3445 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity3445 was specifically bound to PPARy @entity21244 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity3445 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity28 and @entity1560 . Our findings shed new light on the mechanism of @entity9052 in the treatment of @entity209 .

title: @entity71800 , a novel PPARy antagonist from @entity9052 , alleviates XXXX in @entity19 .

answer: @entity1560 :: (MESH:D005234,Disease) :: ['steatosis']


abstract: @entity28 is prevalent worldwide, and is highly associated with @entity209 , such as insulin resistance, @entity407 and @entity1560 . @entity9052 has been used as food and traditional herbal medicine for the treatment of various @entity209 . However, the molecular mechanisms how @entity9052 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity71800 ( @entity3445 ), a major @entity9052 constituent, inhibited @entity6170 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity28 (DIO) @entity19 , @entity3445 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity1560 , in the livers. These effects were confirmed with genetically @entity28 ob/ob @entity19 . A reporter gene assay showed that @entity3445 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity3445 was specifically bound to PPARy @entity21244 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity3445 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity28 and @entity1560 . Our findings shed new light on the mechanism of @entity9052 in the treatment of @entity209 .

title: @entity71800 , a novel PPARy antagonist from XXXX , alleviates @entity1560 in @entity19 .

answer: @entity9052 :: (4054,Species) :: ['Panax ginseng']


abstract: @entity28 is prevalent worldwide, and is highly associated with @entity209 , such as insulin resistance, @entity407 and @entity1560 . @entity9052 has been used as food and traditional herbal medicine for the treatment of various @entity209 . However, the molecular mechanisms how @entity9052 and its components participate in the regulation of lipogenesis are still largely unclear. Here, we identified that @entity71800 ( @entity3445 ), a major @entity9052 constituent, inhibited @entity6170 -supported adipocyte differentiation of 3T3-L1 cells by repressing the expression of lipogenesis-related gene expression. In high-fat diet-induced @entity28 (DIO) @entity19 , @entity3445 reduced body weight and serum lipid levels, improved insulin resistance, as well as morphology and lipid accumulation, @entity1560 , in the livers. These effects were confirmed with genetically @entity28 ob/ob @entity19 . A reporter gene assay showed that @entity3445 specifically inhibited the transactivity of PPARy, but not PPAR a, b/   and LXR a, b. TR-FRET assay revealed that @entity3445 was specifically bound to PPARy @entity21244 , which was further confirmed by the molecular docking study. Our data demonstrate that @entity3445 is a novel PPARy antagonist. The inhibition of PPARy activity could be a promising therapy for @entity28 and @entity1560 . Our findings shed new light on the mechanism of @entity9052 in the treatment of @entity209 .

title: @entity71800 , a novel PPARy antagonist from @entity9052 , alleviates @entity1560 in XXXX .

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: OBJECTIVE: In European countries more than 50% of the population are overweight, 30% with @entity28 . In Poland overweight was present in 41% of @entity1 and 28.7% of @entity1 ( @entity28 15.7% and 19.9%). It was examined whether @entity28 affects serum levels of @entity2252 ( @entity2252 ) and @entity650 ( @entity650 ), which may lead to the consequences of @entity28 , such as type 2 @entity6 , @entity101 , and finally the @entity209 . We aimed to examine whether @entity28 affects the serum levels of @entity2252 and @entity650 . @entity1 AND METHODS: The study involved 144 @entity1 aged 45 to 86 years, 80 subjects with diagnosed @entity28 and 64 with normal body weight,  <= 65 years old (n = 45) and > 65 years old (n = 99). All @entity1 underwent tests of @entity413 , total @entity165 , HDL, LDL, @entity1674 levels, using routine laboratory methods. A test of the concentration of @entity650 and @entity2252 was carried out. The declared level of physical activity (gymnastics, cycling or walking) was considered. RESULTS: It was shown that in @entity1  <= 65 years old, @entity28 was associated with higher levels of @entity650 . When the test group, divided into the above categories, was analyzed for the diagnosis of @entity101 , @entity712 or @entity6 , no statistically significant differences in the investigated parameters were detected. The concentration of @entity2252 did not differ in the investigated subjects, regardless of sex, age, @entity28 , or the declared physical activity. CONCLUSIONS: The concentration of @entity650 in younger @entity1 , including those with normal body weight, correlated with total @entity165 and @entity412 levels, and it was significantly higher in @entity28 @entity1 compared to those with normal body weight.

title: Obesity itself does not influence XXXX serum levels in adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'PATIENTS', 'people', 'men']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity2252 :: ('627', 'Gene') :: ['brain-derived neurotrophic factor', 'BDNF']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity2252 :: (627,Gene) :: ['BDNF']


abstract: There have been significant changes in @entity497 ( @entity497 ) in @entity1 in the last decade. These changes relate to epidemiology and clinical presentation. Resistance to antibiotics is also a changing issue. These all have to be considered when treating @entity497 . In this document, two of the main Spanish pediatric societies involved in the treatment of @entity497 in @entity1 , propose a consensus concerning therapeutic approach. These societies are the Spanish Society of @entity166 and the Spanish Society of Paediatric @entity764 . The Advisory Committee on Vaccines of the Spanish Association of Paediatrics ( @entity3895 -AEP) has also been involved in the prevention of @entity497 . An attempt is made to provide up-to-date guidelines to all paediatricians. The first part of the statement presents the approach to ambulatory, previously healthy @entity1 . We also review the prevention with currently available vaccines. In a next second part, special situations and complicated forms will be addressed.

title: [Community acquired pneumonia in XXXX : Outpatient treatment and prevention.]

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity497 :: ('MESH:D003147', 'Disease') :: ['CAP', 'community acquired pneumonia']

entities_list: @entity764 :: ('MESH:D013898', 'Disease') :: ['Chest Diseases']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['Paediatric Infectious Diseases']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: Genes and the environment both influence the metabolic processes that determine fitness. To illustrate the importance of metabolism for @entity1 brain evolution and health, we use the example of lipid energy metabolism, i.e. the use of fat (lipid) to produce energy and the advantages that this metabolic pathway provides for the brain during environmental energy shortage. We briefly describe some features of metabolism in ancestral organisms, which provided a molecular toolkit for later development. In modern @entity1 , lipid energy metabolism is a regulated multi-organ pathway that links @entity1674 in fat tissue to the mitochondria of many tissues including the brain. Three important control points are each suppressed by insulin. (1) Lipid reserves in adipose tissue are released by lipolysis during fasting and stress, producing @entity1718 (FAs) which circulate in the blood and are taken up by cells. (2) FA oxidation. Mitochondrial entry is controlled by @entity13513 ( @entity13513 ). Inside the mitochondria, FAs undergo beta oxidation and energy production in the Krebs cycle and respiratory chain. (3) In liver mitochondria, the @entity2453 ( @entity2453 ) pathway produces @entity6178 bodies for the brain and other organs. Unlike most tissues, the brain does not capture and metabolize circulating FAs for energy production. However, the brain can use @entity6178 bodies for energy. We discuss two examples of genetic metabolic traits that may be advantageous under most conditions but deleterious in others. (1) A @entity13513 variant prevalent in Inuit @entity1 may allow increased FA oxidation under nonfasting conditions but also predispose to hypoglycemic episodes. (2) The thrifty genotype theory, which holds that energy expenditure is efficient so as to maximize energy stores, predicts that these adaptations may enhance survival in periods of famine but predispose to @entity28 in modern dietary environments.

title: Metabolism as a tool for understanding XXXX brain evolution: Lipid energy metabolism as an example.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human', 'people']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity13513 :: ('1374', 'Gene') :: ['CPT1', 'carnitine palmitoyl transferase 1', 'CPT1A']

entities_list: @entity2453 :: ('MESH:C008047', 'Chemical') :: ['3-hydroxy-3-methylglutaryl-CoA', 'HMG-CoA']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: To investigate the pathology characteristics of @entity6515 with @entity281 , in order to reduce the recurrence rate after surgery and improve operative technique. METHOD: Twenty-five @entity1 diagnosed as @entity6515 with @entity281 were analyzed. There were 14 @entity1 in @entity281 history group, 9 in infective stage group, and 2 in recurrence group respectively. The whole piece of @entity292 and scar tissue was completely excised during operation. The specimens were observed by naked eye and serial tissue sections were analyzed. RESULT: (1) Macroscopically, in @entity281 history group, initial morphology can be maintained near the @entity292 orifice, but the distal tissue was dark red scar tissue. In infective stage group, the distal tissue of the specimens was granulation tissue and cicatricial tissue. The granulation tissue was crisp and bright red. In recurrence group, @entity75 with severe @entity4 was observed, with a classical dumb-bell appearence. (2) Microscopically, in @entity281 history group and recurrence group, we can see that the distal @entity292 tissue was discontinuous and was separated by scar tissue. In infective stage group, we can find neo-angiogenesis and infiltration of plasma cells, lymphocytes, neutrophil between interrupted @entity292 tissues. (3) All @entity1 were followed up for 6-12 month, without recurrence. CONCLUSION: The @entity292 tissue of @entity6515 with @entity281 was divided by the scar tissue, and they did not communicate with each other. Complete delineation of @entity292 is hardly achieved by @entity6693 staining. Radical excision of the @entity292 and scar tissue may help to avoid leaving viable squamous epithelial remnants and reduce the recurrence rate.

title: [ XXXX : a histopathology observation].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6515 :: ('MESH:C563015', 'Disease') :: ['congenital preauricular fistula']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['multicystic lesions']

entities_list: @entity6693 :: ('MESH:D008751', 'Chemical') :: ['methylene blue']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity6515 :: (MESH:C563015,Disease) :: ['Congenital preauricular fistula infection']


abstract: INTRODUCTION: Dual supraorbital and occipital nerve stimulation (SONS and ONS) have shown promising efficacy in treating @entity10 . However, its functional outcome is not well studied. We report functional outcome of combined SONS and ONS for @entity2704 using verified metrics. METHODS: Consecutive @entity1 who have both supraorbital and occipital nerve stimulators and also underwent @entity2704 Disability Assessment (MIDAS) and Beck Depression Index (BDI) both pre- and postoperatively were studied. Outcome variables included net improvement of ranked MIDAS and BDI scores. Predictor variables included @entity1 with 50% improvement of @entity158 , disability status, number of years from diagnosis to implantation, and narcotic use. Multivariate analysis of variance (MANOVA) was performed to assess the correlation between the outcome and predictor variables. RESULTS: Sixteen @entity1 (12 female; age average 51.8 years) were studied. Follow-up ranged from 5 to 80 months (average 44.5    21.4 months). Eight had a positive response (50% improvement in @entity10 ) at most recent follow-up. Fifty percent improvement in @entity10 was the only predictor of outcome variables combined (total MIDAS, MIDAS-B, and BDI) (P = .021). Of note, this improvement in functional outcome was only significant during the perioperative period and not throughout the length of follow-up. No other predictive factors were significantly correlated with the functional outcomes. Among the predictor variables, a strong correlation was found for disability status being inversely related to reporting 50% improvement in @entity10 (r = -0.582). CONCLUSION: In @entity1 who had positive response to SONS and ONS, functional status as reflected by MIDAS and BDI had overall improvement in perioperative period. Unfortunately, this effect waned over the long-term follow-up.

title: 185   Long-term Follow-up in Functional Outcomes of Combined Supraorbital Nerve Stimulation and Occipital Nerve Stimulation for Chronic Headache XXXX .

entities_list: @entity2704 :: ('MESH:D008881', 'Disease') :: ['migraine', 'Migraine']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['primary headaches', 'headache']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: INTRODUCTION: Better ways to predict motor outcome following hemispherectomy are necessary to implement the informed consent process in @entity1 with @entity302 . The volumetric analysis of cerebral peduncles and cerebellar hemispheres in @entity1 who had undergone hemispherectomy may determine prognostic implications for @entity86 . METHODS: Twenty-two @entity1 who underwent hemispherectomy at our institution, who had follow-up of at least 6 months and had accessible preoperative volumetric MRIs were retrospectively included. With the use of iPlan/BrainLAB imaging software, the volumes of bilateral cerebral peduncles and cerebellar hemispheres were calculated. After defining the borders of region of interest the volume of the resulting enclosed figure was calculated using software iPlan cranial via a semiautomatic voxel-based segmentation method. RESULTS: Eleven @entity1 were found to have improved or unchanged @entity1269 (group 1); these were compared with 11 who had worsening @entity1269 following hemispherectomy (group 2). The ratio of ipsilateral/contralateral peduncle volume in group 1 was 0.535 with a standard deviation of 0.23 (laterality refers to side of hemispherectomy), significantly lower than the ratio in group 2 (0.79 with a standard deviation of 0.21; P value <.0139). No @entity1 with a peduncle ratio of less than 0.5 experienced worsening of @entity1269 . CONCLUSION: While @entity1 who undergo hemispherectomy are heterogeneous, we report a method of predicting @entity86 only using a standard volumetric MRI. This information could be used in the preoperative discussions with @entity1 and families to help better understand that chance of retaining baseline motor function.

title: 194   Volumetric Analysis of Cerebral Peduncles and Cerebellar Hemispheres for Predicting XXXX Following Hemispherectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative hemiparesis']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['hemispheric epilepsy']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis']

answer: @entity1269 :: (MESH:D010291,Disease) :: ['Hemiparesis']


abstract: The use of "Energy Drinks" ( @entity457 ) is increasing in India. Students specially use these drinks to rejuvenate after strenuous exercises or as a stimulant during exam times. The most common ingredient in EDs is @entity5834 and a popular @entity457 available and commonly used is Red Bull, containing 80 mg of @entity5834 in 250 ml bottle. The primary aim of this study was to investigate the effects of Red Bull energy drink on Auditory reaction time and @entity2472 . A homogeneous group containing twenty medical students (10 males, 10 females) participated in a crossover study in which they were randomized to supplement with Red Bull (2 mg/kg body weight of @entity5834 ) or isoenergetic isovolumetric noncaffeinated control drink (a combination of Appy Fizz, Cranberry juice and soda) separated by 7 days. @entity2472 ( @entity2472 ) was recorded as the highest of the 3 values of maximal isometric force generated from the dominant hand using hand grip dynamometer (Biopac systems). Auditory reaction time (ART) was the average of 10 values of the time interval between the click sound and response by pressing the push button using hand held switch (Biopac systems). The energy and control drinks after one hour of consumption significantly reduced the Auditory reaction time in males ( @entity457 232    59 Vs 204    34 s and Control 223    57 Vs 210    51 s; p < 0.05) as well as in females ( @entity457 227    56 Vs 214    48 s and Control 224    45 Vs 215    36 s; p < 0.05) but had no effect on @entity2472 in either sex (males @entity457 381    37 Vs 371    36 and Control 375    61 Vs 363    36 Newton, females @entity457 227    23 Vs 227    32 and Control 234    46 Vs 228    37 Newton). When compared across the gender groups, there was no significant difference between males and females in the effects of any of the drinks on the ART but there was an overall significantly lower @entity2472 in females compared to males. Both energy drink and the control drink significantly improve the reaction time but may not have any effect on muscular performance. Energy drink per se is no better than control drink, which may indicate that there is no role of @entity5834 in the beneficial effect seen after the drinks.

title: Effect of red bull energy drink on auditory reaction time and maximal XXXX .

entities_list: @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine']

entities_list: @entity2472 :: ('MESH:C536214', 'Disease') :: ['MVC', 'Maximal voluntary contraction']

answer: @entity2472 :: (MESH:C536214,Disease) :: ['voluntary contraction']


abstract: The present paper aims to investigate whether or not @entity11539 ( @entity11539 ) exists in @entity957 ( @entity957 ), and to elucidate its relationship to microvessel density (MVD), @entity14813 ( @entity14813 ) expressionb and clinicopathological factors of @entity1 with @entity957 . @entity11539 , score of MVD and expression of @entity14813 protein were detected by immunohistochemistry and histochemistry in 83 specimens of @entity957 tissue and 20 specimens of nor- mal laryngeal tissue. The positive rate of @entity11539 in normal laryngeal tissues was 0%, and was 33.7% in @entity957 tissues. There was a significant difference between the two groups (P<0. 01). @entity11539 or MVD was significantly related to differentiation, pTNM stages and lymph node metastasis of @entity957 (P<0.05), but not to age, gender and @entity5 site (P>0. 05). And there was a positive correlation between every two of @entity11539 , score of MVD, and @entity14813 protein (P< 0. 05). The results suggest that expression of @entity14813 protein may be related to the initiation, angiogenesis and @entity11539 formation in @entity957 ; And @entity11539 , angiogenesis and @entity14813 protein may be involved in the development, invasion and metastasis of @entity957 .

title: [Vasculogenic mimicry in XXXX and its clinicopathological significance].

entities_list: @entity11539 :: ('MESH:D018783', 'Disease') :: ['vasculogenic mimicry', 'VM']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['LSCC', 'laryngeal squamous cell carcinoma']

answer: @entity957 :: (MESH:D002294,Disease) :: ['laryngeal squamous cell carcinoma']


abstract: BACKGROUND: An objective assessment of quadriceps strength after anterior cruciate ligament reconstruction (ACLR) is an important clinical measure to determine readiness to @entity2587 ( @entity2587 ). Not all clinicians are equipped with the means to objectively quantify quadriceps strength limb symmetry indices (Q-LSIs) via lower extremity isokinetic dynamometers, as recommended by previous studies. PURPOSE/HYPOTHESIS: The purpose of this study was to determine whether the International Knee Documentation Committee 2000 Subjective Knee Form (IKDC) score at time of @entity2587 was a predictor of quadriceps strength in a young, athletic population after ACLR. Two hypotheses were tested: (1) Individuals with higher self-reports of function would demonstrate better quadriceps strength of the involved limb than individuals with lower self-reports of function at the time of @entity2587 , and (2) individuals with higher self-reports of function would have normal quadriceps strength limb symmetry. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2. METHODS: At time of @entity2587 , 139 subjects who had undergone ACLR completed the IKDC. In addition, an isometric quadriceps strength test (Biodex dynamometer) was performed on both lower extremities. Peak torques were calculated, as was the Q-LSI, determined by the formula (involved limb peak torque/uninvolved limb peak torque) * 100%. @entity1 were dichotomized based on IKDC scores: high IKDC (IKDC >= 90) and low IKDC (IKDC <90). Two-way analysis of variance was used to determine the effect of limb (involved vs uninvolved) and group (high vs low IKDC) on isometric quadriceps strength. Chi-square and logistic regression analyses were then performed to determine whether IKDC scores could predict Q-LSI. RESULTS: At time of @entity2587 , a significant correlation between IKDC scores and (1) peak isometric torque (r = 0.282, P < .001) and (2) Q-LSI (r = 0.357, P < .001) was observed. Individuals with IKDC scores >= 90 were 3 times (OR = 3.4; 95% CI, 1.71-6.93) more likely to demonstrate higher Q-LSI (>= 90%). An IKDC score >= 94.8 predicted Q-LSI >= 90% with high sensitivity (0.813) and moderate specificity (0.493). CONCLUSION: @entity1 with higher IKDC scores demonstrated an increased likelihood of presenting with greater involved limb quadriceps strength and better Q-LSI. Based on the results of this study, a @entity1 -reported outcome measure, such as the IKDC, may be able to serve as a valuable screening tool for the identification of @entity121 in this population; however, it should not be considered an accurate surrogate for isokinetic dynamometry. Furthermore, a score of >= 94.8 on the IKDC is likely to indicate that a @entity1 's quadriceps strength is at an acceptable @entity2587 level.

title: The Influence of Quadriceps Strength Asymmetry on XXXX -Reported Function at Time of Return to Sport After Anterior Cruciate Ligament Reconstruction.

entities_list: @entity2587 :: ('MESH:D001265', 'Disease') :: ['return to sport', 'RTS']

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'Participants']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['quadriceps strength deficits']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: OBJECTIVE: To observe the effects of daily consumption of milk powder on Healthy young @entity1 , including the effect on menstrual cycles, ovulation time and sex hormone concentrations in morning urine. METHOD: Thirty-two young @entity1 were recruited as subjects and randomly assigned into two groups for a milk powder consumption experiment which lasted three menstrual cycles. The first menstrual cycle is control cycle, the second menstrual cycle is milk-taking cycle. The subjects take milk diluted by 33g or 55g milk powder each day, from the 4th to the 24th day of the second menstrual cycle. The third menstrual cycles is control cycle after milk-taking. During the whole three menstrual cycle, record the length of each menstrual cycle, determine ovulation time by using basal body temperature and oviposit test paper, collect their morning urine samples at specified times (the 4th, 7th, 10th, 13rd, 16th, 19th and 24th day of first and the third menstrual cycle; the 4th, 5th, 6th, 7th, 9th, 12nd, 15th, 18th, 21st and 24th day of the second menstrual cycle), determine the concentrations of @entity53 , @entity12778 and @entity1011 in morning urine samples; draw the curve of the concentration changing over time and calculate the area under the curve to the 24th day. RESULT: In the high-dose group, the mean of the menstrual cycle length are (29.60   3.180) d, (28.87    3.021) d, (29.60    2.995) d, the mean of the ovulation time are (15.47    2.200) d. There was no significant difference in menstrual cycle length and ovulation time among cycles and between groups (P>0.05). Calculate the difference between the first and the second menstrual cycle, and the difference between the two groups. In the high-dose group, the area under the curve of @entity53 concentrations adjusted by @entity1011 are (7160.28   2305.52), (6700.26   2066.67); (6676.24   2573.89); the area under the curve of @entity12778 concentrations corrected by @entity1011 are (51.93   18.80), (44.55   14.62) and (46.49   22.44). In the low-dose group, the area under the curve of @entity53 concentrations adjusted by @entity1011 are (6838.21   2573.89), (6611.33   1648.21) and (5949.24   1437.54)/ The area under the curve of @entity12778 concentrations adjusted by @entity1011 are (49.25   15.68), (48.79   15.61) and (43.45   12.77). There   s no significant difference of the area under the curve among three menstrual cycles and between two groups (P>0.05). CONCLUSION: 21 days    continuous daily consumption of milk powder does not have a significant impact on menstrual cycle, or on the @entity53 / @entity12778 concentrations in morning urine.

title: [Effects of daily consumption of milk powder on menstrual cycles and urine sex hormone concentrations of young XXXX ].

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity12778 :: ('MESH:D011276', 'Chemical') :: ['pregnanediol']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND: A transient endothelial hyperpermeability is a hallmark of severe @entity281 . @entity5595 ( @entity5596 ) maintains vascular integrity and protects against plasma leakage. We related plasma @entity5596 levels to dengue-induced plasma leakage and studied mechanisms that may underlie the decrease in @entity5596 levels in dengue. METHODS: We determined circulating levels of @entity5596 in 44 Indonesian adults with acute dengue and related levels to plasma leakage, as determined by daily ultrasonography, and to levels of its chaperone apolipoprotein M, other lipoproteins and platelets. RESULTS: Plasma @entity5596 levels were decreased during dengue and @entity1 with plasma leakage had lower median levels compared to those without (638 vs. 745  nM; p  <  0.01). @entity18791 and other lipoprotein levels were also decreased during dengue, but did not correlate to @entity5596 levels. Platelet counts correlated positively with @entity5596 levels, but @entity5596 levels were not higher in frozen-thawed platelet rich plasma, arguing against platelets as an important cellular source of @entity5596 in dengue. CONCLUSIONS: Decreased plasma @entity5596 levels during dengue are associated with plasma leakage. We speculate that decreased levels of @entity18791 underlies the lower @entity5596 levels. Modulation of @entity5596 levels and its receptors may be a novel therapeutic intervention to prevent plasma leakage in dengue.

title: Decreased plasma levels of the endothelial protective XXXX are associated with dengue-induced plasma leakage.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['dengue infections']

entities_list: @entity5595 :: ('MESH:C060506', 'Chemical') :: ['Sphingosine-1-phosphate']

answer: @entity5595 :: (MESH:C060506,Chemical) :: ['sphingosine-1-phosphate']


abstract: A 58-year-old @entity1 was transferred to us from his local hospital because of failure to control his @entity360 by endoscopic hemostasis. Abdominal imaging suggested a hypervascular @entity5 of the pancreatic head (36  mm diameter), and laboratory testing showed an elevated serum @entity8243 level (17,800  pg/mL). Gastroduodenal endoscopy revealed @entity4773 from the ampulla of Vater. The selective arterial secretagogue injection test suggested a @entity7581 in the pancreatic head, but no @entity7581 in the pancreatic tail. The @entity1 was diagnosed with solitary pancreatic head @entity7581 complicated by hemosuccus pancreaticus, and pancreaticoduodenectomy was performed. Intraoperatively, the diagnosis was changed to primary @entity1600 without pancreatic involvement. The @entity360 stopped postoperatively and serum @entity8243 levels returned to normal. Histological examination of the surgical specimens revealed a small @entity7581 in the duodenum (7  mm diameter). The final diagnosis was microgastrinoma of the duodenum with peripancreatic lymph node @entity3 . The cause of @entity548 from the ampulla of Vater was initially obscure, but eventually a @entity548 with moderate atypia was found in the common bile duct, indicating @entity5 ( @entity5 ). This is the first report of @entity7252 due to @entity5 with @entity7581 .

title: XXXX due to @entity5 associated with Zollinger-Ellison syndrome.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic erosion', 'bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'BilIN', 'biliary intraepithelial neoplasia']

entities_list: @entity4773 :: ('MESH:D004381', 'Disease') :: ['multiple duodenal ulcers and active bleeding']

entities_list: @entity1600 :: ('MESH:D014388', 'Disease') :: ['peripancreatic lymph node gastrinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding']

entities_list: @entity7581 :: ('MESH:D015408', 'Disease') :: ['submucosal gastrinoma', 'gastrinoma']

entities_list: @entity7252 :: ('MESH:D006431', 'Disease') :: ['hemobilia']

answer: @entity7252 :: (MESH:D006431,Disease) :: ['Hemobilia']


abstract: A 58-year-old @entity1 was transferred to us from his local hospital because of failure to control his @entity360 by endoscopic hemostasis. Abdominal imaging suggested a hypervascular @entity5 of the pancreatic head (36  mm diameter), and laboratory testing showed an elevated serum @entity8243 level (17,800  pg/mL). Gastroduodenal endoscopy revealed @entity4773 from the ampulla of Vater. The selective arterial secretagogue injection test suggested a @entity7581 in the pancreatic head, but no @entity7581 in the pancreatic tail. The @entity1 was diagnosed with solitary pancreatic head @entity7581 complicated by hemosuccus pancreaticus, and pancreaticoduodenectomy was performed. Intraoperatively, the diagnosis was changed to primary @entity1600 without pancreatic involvement. The @entity360 stopped postoperatively and serum @entity8243 levels returned to normal. Histological examination of the surgical specimens revealed a small @entity7581 in the duodenum (7  mm diameter). The final diagnosis was microgastrinoma of the duodenum with peripancreatic lymph node @entity3 . The cause of @entity548 from the ampulla of Vater was initially obscure, but eventually a @entity548 with moderate atypia was found in the common bile duct, indicating @entity5 ( @entity5 ). This is the first report of @entity7252 due to @entity5 with @entity7581 .

title: @entity7252 due to XXXX associated with Zollinger-Ellison syndrome.

answer: @entity5 :: (MESH:D009369,Disease) :: ['biliary intraepithelial neoplasia']


abstract: One of directions of the search of hormonal signaling systems regulators is the development of peptides that correspond to the cytoplasmic regions of @entity71801 ( @entity71801 ). Modification of the pepti- des with hydrophobic radicals increases their efficiency and selectivity. But currently is not studied as the acti- vity of the peptide depends on the localization of the hydrophobic radicals, their number and the chemical natu- re. The aim of this work was the synthesis of modified by @entity844 radicals derivatives of peptide 562-572 corresponding to the C-terminal region of @entity7813 ( @entity7813 ), and the study of regulatory ef- fects of the acylated @entity7813 -peptides on the basal and hormone-stimulated activity of adenylyl cyclase (AC) in the @entity35 tissues. To elucidate the effect of localization of hydrophobic radicals and their number the modification of peptide 562-572 only at the N- or C-terminus or at both ends was carried out. To study the effect of hydrop- hobicity the residues ofpalmitic ( @entity15409 ) and decanoic (Dec) acids were selected. Using a solid phase strategy we have synthesized unmodified peptide NDTKIAKK-Nle-A562-572-KA (1) and five of its acylated analogues, such as N[K(Dec)]DTKIAKK-Nle-A562-572-KA (2), NKDTKIAKK-Nle-A562-572-[K(Dec)]A (3), N[K(Dec)] DTKIAKK-Nle-A562-572-[K(Dec)]A (4), N[K( @entity15409 )]DTKIAKK-Nle-A562-572-KA (5), and NKDTKIAKK-Nle- A562--572-[K( @entity15409 )]A (6). Peptide 6 modified with @entity2365 at the C-terminus to a large extent increased the ba- sal AC activity and reduced AC stimulating effect of @entity1 chorionic gonadotropin (hCG) in the testes of @entity35 , peptides 3 and 4 modified with @entity19658 at the C-terminus were less effective, but exceeded in activity the un- modified peptide 1, while peptides 2 and 5 acylated at the N-terminus were little active. The action of peptides was characterized by the tissue and the receptor specificity. Thus, the modification of @entity7813 -peptide 562-572 with @entity844 radicals at the C-terminus increases its regulatory effect on the functional activity of the adenyla- te cyclase system in the @entity35 testes, indicating promising the modification of @entity71801 -peptides with hydrophobic radicals. These data support the hypothesis that the hydrophobic radical to be localized in the locus of @entity71801 -peptide, where a transmembrane domain is located in the receptor.

title: [Regulation of adenylyl cyclase activity in the @entity35 testes by acylated derivatives of peptide 562-572 of XXXX ].

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity2365 :: ('CHEBI:7896', 'Chemical') :: ['palmitate']

entities_list: @entity19658 :: ('CHEBI:27689', 'Chemical') :: ['decanoate']

entities_list: @entity7813 :: ('25477(Tax:10116)', 'Gene') :: ['luteinizing hormone receptor', 'LHR']

entities_list: @entity71801 :: ('363866(Tax:10116)', 'Gene') :: ['G-protein-coupled receptors', 'GPCR']

answer: @entity7813 :: (25477(Tax:10116),Gene) :: ['luteinizing hormone receptor']


abstract: One of directions of the search of hormonal signaling systems regulators is the development of peptides that correspond to the cytoplasmic regions of @entity71801 ( @entity71801 ). Modification of the pepti- des with hydrophobic radicals increases their efficiency and selectivity. But currently is not studied as the acti- vity of the peptide depends on the localization of the hydrophobic radicals, their number and the chemical natu- re. The aim of this work was the synthesis of modified by @entity844 radicals derivatives of peptide 562-572 corresponding to the C-terminal region of @entity7813 ( @entity7813 ), and the study of regulatory ef- fects of the acylated @entity7813 -peptides on the basal and hormone-stimulated activity of adenylyl cyclase (AC) in the @entity35 tissues. To elucidate the effect of localization of hydrophobic radicals and their number the modification of peptide 562-572 only at the N- or C-terminus or at both ends was carried out. To study the effect of hydrop- hobicity the residues ofpalmitic ( @entity15409 ) and decanoic (Dec) acids were selected. Using a solid phase strategy we have synthesized unmodified peptide NDTKIAKK-Nle-A562-572-KA (1) and five of its acylated analogues, such as N[K(Dec)]DTKIAKK-Nle-A562-572-KA (2), NKDTKIAKK-Nle-A562-572-[K(Dec)]A (3), N[K(Dec)] DTKIAKK-Nle-A562-572-[K(Dec)]A (4), N[K( @entity15409 )]DTKIAKK-Nle-A562-572-KA (5), and NKDTKIAKK-Nle- A562--572-[K( @entity15409 )]A (6). Peptide 6 modified with @entity2365 at the C-terminus to a large extent increased the ba- sal AC activity and reduced AC stimulating effect of @entity1 chorionic gonadotropin (hCG) in the testes of @entity35 , peptides 3 and 4 modified with @entity19658 at the C-terminus were less effective, but exceeded in activity the un- modified peptide 1, while peptides 2 and 5 acylated at the N-terminus were little active. The action of peptides was characterized by the tissue and the receptor specificity. Thus, the modification of @entity7813 -peptide 562-572 with @entity844 radicals at the C-terminus increases its regulatory effect on the functional activity of the adenyla- te cyclase system in the @entity35 testes, indicating promising the modification of @entity71801 -peptides with hydrophobic radicals. These data support the hypothesis that the hydrophobic radical to be localized in the locus of @entity71801 -peptide, where a transmembrane domain is located in the receptor.

title: [Regulation of adenylyl cyclase activity in the XXXX testes by acylated derivatives of peptide 562-572 of @entity7813 ].

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: BACKGROUND AND AIMS: 99mTc-pertechnetate scintigraphy has long been used for detection of @entity356 ( @entity356 ) in the medical practice and evaluation of @entity1 with lower @entity360 . In the current study, we reviewed the available medical literature in this regard. METHODS: Medline and SCOPUS were searched for relevant studies. Studies with sample size of at least 5 @entity1 which provided enough numerical data to calculate the sensitivity and/or specificity of 99mTc-pertechnetate for detection of @entity356 were includ ed in the systematic review. RESULTS: Overall 40 studies were included in our systematic review. Overall diagnostic indices of the 99mTc-pertechnetate scintigraphy for @entity356 diagnosis were: sensitivity 92.1% [95% CI: 90.2-93.8], specificity 95.4% [943-963], positive likelihood ratio 16.5 [9.9-27.], negative likelihood ratio 0.15 [0.1-0.2], diagnostic odds ratio 120.7 [73-199]. The pooled sensitivity was higher for studies using H2 blockers as a premedication (92.4% vs. 86.4%), studies using delayed imaging (943% vs. 88.4%), @entity1 (92.3% vs. 81.8%), and @entity1 with @entity360 (953% vs. 75.3%). CONCLUSIONS: 99mTc-pertechnetate imaging is a highly accurate diagnostic modality for detection of @entity356 . This imaging is more accurate in @entity1 and @entity1 presenting with @entity360 . Premedication with H2 blockers and delayed imaging can increase the diagnostic accuracy and should be routinely included in the imaging protocol.

title: 99mTc-Pertechnetate imaging for detection of XXXX : a systematic review and meta-analysis of the pertinent literature..

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['ectopic gastric mucosa', 'EGM']

answer: @entity356 :: (MESH:D013274,Disease) :: ['ectopic gastric mucosa']


abstract: OBJECTIVE: To explore the distribution characteristics of basic syndromes and its related factors in @entity1 with @entity454 ( @entity454 ). METHODS: The complete data of 538 @entity1 with @entity454 were collected and initial database was established with Epidata 3. 0. TCM syndrome typing was performed. The distribution characteristics of basic syndromes were analyzed using SPSS 17. 0 Software. The univariate and multivariate Logistic regression analyses were performed with SPSS 17. 0 Software to determine basic syndrome related factors such as age, engaged professionals, @entity25 , @entity308 , @entity1032 , interpersonal relations, work fatigue, stimulating beverage, exercise conditions, Western medicine type of @entity1142 , and so on. RESULTS: The TCM syndrome frequency of @entity454 @entity1 was sequenced from high to low as @entity465 (380 cases, 70.6%), qi stagnation syndrome (337 cases, 62.6%), blood @entity465 (234 cases, 43.5%), @entity20247 (220 cases, 40.9%), @entity14717 (197 cases, 36.6%), and others(58 cases, 10. 8%) . Most @entity1 were complicated with complex syndromes, and the most common complex syndromes were @entity942 complicated qi stagnation syndrome (275 cases, 51.1%) and @entity942 complicated blood @entity465 (222 cases, 41.3%). Aging, work fatigue, and exercise conditions were main related factors for @entity465 (P <0. 01, P <0. 05). Poor emotional ( @entity308 and @entity148 tendencies), @entity1032 , interpersonal relations, @entity1142 were main related factors for qi stagnation syndrome (P <0.01). Sleep quality and poor emotional ( @entity308 and @entity148 tendencies) were main related factors for blood @entity465 (P <0. 01, P < 0.05). Stimulating beverages were main related factor for @entity20247 (P <0.05). Engaged in mental work and @entity73 were main related factors for @entity14717 (P < 0. 01, P <0. 05). CONCLUSIONS: @entity454 is featured as complex syndromes. The most common complex syndromes were @entity942 complicated qi stagnation syndrome and @entity942 complicated blood @entity465 . Basic syndrome related factors such as age, engaged professionals, @entity25 , poor emotional ( @entity308 and @entity148 tendencies), @entity1032 , interpersonal relations, work fatigue, stimulating beverage, exercise conditions, Western medicine type of @entity1142 were associated with the distribution of @entity454 .

title: [Distribution characteristics of basic XXXX and its related factors analysis].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental stress']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity14717 :: ('MESH:D016711', 'Disease') :: ['yang deficiency syndrome']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['slow transit constipation']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['qi deficiency syndrome', 'deficiency syndrome']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['defecation barriers constipation', 'constipation']

entities_list: @entity20247 :: ('MESH:D016710', 'Disease') :: ['yin deficiency syndrome']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep quality']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['qi deficiency']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['CFC syndromes', 'chronic functional constipation', 'CFC']

answer: @entity454 :: (MESH:D007676,Disease) :: ['syndromes of chronic functional constipation']


abstract: OBJECTIVE: To observe the effect of xuebijing Injection (XI) on perioperative @entity3459 and inflammatory reaction in senile @entity1 receiving @entity572 ( @entity572 ). METHODS: Totally eighty @entity1 receiving @entity572 at Luoyang Orthopedics Hospital, 65 to 85 years old, were randomly assigned to the control group (40 cases) and the treatment group (40 cases). All @entity1 received routine perioperative therapies. Those in the treatment group received XI (adding 50 mL XI in 100 mL normal saline, 30 min each time). XI was continually injected after @entity572 , twice daily for 3 successive days. Blood samples were harvested on the morning of the 2nd admission day (TO), immediately after operation (T1), on the morning of the 3rd day after operation (T3), and on the morning of the 5th day after operation (T4) to detect prothrombin time (PT), @entity556 time (TT), activated partial thromboplastin time (APTT), levels of FIB and D-dimer (D-D), changes of white blood cell (WBC), neutrophils (N), @entity1851 ( @entity1851 ), erythrocyte sedimentation rate (ESR), and @entity650 . Complications of surgery were compared between the two groups. RESULTS: There was no statistical difference in operation time, intraoperative @entity190 , and blood transfusion between the two groups (P >0.05). Compared with TO in the same group, WBC, N, @entity1851 , ESR, @entity650 , PT, TT, and D-D all increased in the control group at T1-T4 (P < 0.05); APTT increased at T1-T2 (P <0.05); FIB increased at T1-T3 (P <0.05). WBC, N, @entity650 , PT, and D-D all increased in the treatment group at T1-T3 (P <0.05); @entity1851 and ESR increased at T1-T4 (P < 0.05); TT increased at T1-T2 (P <0.05); APTT and FIB increased at T1 (P <0.05). Compared with the control group at the same time period, WBC, N, @entity1851 , and @entity650 all decreased in the treatment group at T1-T4 (P <0.05), ESR decreased at T3-T4 (P <0.05); PT and TT decreased at T1-T3 (P <0.05); FIB and D-D decreased at T2-T4 (P<0.05). The occurrence of each complication was significantly lower in the treatment groups than in the control group. CONCLUSION: XI could improve the perioperative high @entity3459 state of senile @entity572 @entity1 , inhibit inflammatory reactions, and reduce complications.

title: [Effect of xuebijing injection on perioperative @entity3459 function and inflammatory reaction in senile @entity1 receiving XXXX ].

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['coagulation']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity572 :: (MESH:D006617,Disease) :: ['total hip arthroplasty']


abstract: OBJECTIVE: To observe the effect of xuebijing Injection (XI) on perioperative @entity3459 and inflammatory reaction in senile @entity1 receiving @entity572 ( @entity572 ). METHODS: Totally eighty @entity1 receiving @entity572 at Luoyang Orthopedics Hospital, 65 to 85 years old, were randomly assigned to the control group (40 cases) and the treatment group (40 cases). All @entity1 received routine perioperative therapies. Those in the treatment group received XI (adding 50 mL XI in 100 mL normal saline, 30 min each time). XI was continually injected after @entity572 , twice daily for 3 successive days. Blood samples were harvested on the morning of the 2nd admission day (TO), immediately after operation (T1), on the morning of the 3rd day after operation (T3), and on the morning of the 5th day after operation (T4) to detect prothrombin time (PT), @entity556 time (TT), activated partial thromboplastin time (APTT), levels of FIB and D-dimer (D-D), changes of white blood cell (WBC), neutrophils (N), @entity1851 ( @entity1851 ), erythrocyte sedimentation rate (ESR), and @entity650 . Complications of surgery were compared between the two groups. RESULTS: There was no statistical difference in operation time, intraoperative @entity190 , and blood transfusion between the two groups (P >0.05). Compared with TO in the same group, WBC, N, @entity1851 , ESR, @entity650 , PT, TT, and D-D all increased in the control group at T1-T4 (P < 0.05); APTT increased at T1-T2 (P <0.05); FIB increased at T1-T3 (P <0.05). WBC, N, @entity650 , PT, and D-D all increased in the treatment group at T1-T3 (P <0.05); @entity1851 and ESR increased at T1-T4 (P < 0.05); TT increased at T1-T2 (P <0.05); APTT and FIB increased at T1 (P <0.05). Compared with the control group at the same time period, WBC, N, @entity1851 , and @entity650 all decreased in the treatment group at T1-T4 (P <0.05), ESR decreased at T3-T4 (P <0.05); PT and TT decreased at T1-T3 (P <0.05); FIB and D-D decreased at T2-T4 (P<0.05). The occurrence of each complication was significantly lower in the treatment groups than in the control group. CONCLUSION: XI could improve the perioperative high @entity3459 state of senile @entity572 @entity1 , inhibit inflammatory reactions, and reduce complications.

title: [Effect of xuebijing injection on perioperative XXXX function and inflammatory reaction in senile @entity1 receiving @entity572 ].

answer: @entity3459 :: (MESH:D025861,Disease) :: ['coagulation']


abstract: OBJECTIVE: To observe the effect of xuebijing Injection (XI) on perioperative @entity3459 and inflammatory reaction in senile @entity1 receiving @entity572 ( @entity572 ). METHODS: Totally eighty @entity1 receiving @entity572 at Luoyang Orthopedics Hospital, 65 to 85 years old, were randomly assigned to the control group (40 cases) and the treatment group (40 cases). All @entity1 received routine perioperative therapies. Those in the treatment group received XI (adding 50 mL XI in 100 mL normal saline, 30 min each time). XI was continually injected after @entity572 , twice daily for 3 successive days. Blood samples were harvested on the morning of the 2nd admission day (TO), immediately after operation (T1), on the morning of the 3rd day after operation (T3), and on the morning of the 5th day after operation (T4) to detect prothrombin time (PT), @entity556 time (TT), activated partial thromboplastin time (APTT), levels of FIB and D-dimer (D-D), changes of white blood cell (WBC), neutrophils (N), @entity1851 ( @entity1851 ), erythrocyte sedimentation rate (ESR), and @entity650 . Complications of surgery were compared between the two groups. RESULTS: There was no statistical difference in operation time, intraoperative @entity190 , and blood transfusion between the two groups (P >0.05). Compared with TO in the same group, WBC, N, @entity1851 , ESR, @entity650 , PT, TT, and D-D all increased in the control group at T1-T4 (P < 0.05); APTT increased at T1-T2 (P <0.05); FIB increased at T1-T3 (P <0.05). WBC, N, @entity650 , PT, and D-D all increased in the treatment group at T1-T3 (P <0.05); @entity1851 and ESR increased at T1-T4 (P < 0.05); TT increased at T1-T2 (P <0.05); APTT and FIB increased at T1 (P <0.05). Compared with the control group at the same time period, WBC, N, @entity1851 , and @entity650 all decreased in the treatment group at T1-T4 (P <0.05), ESR decreased at T3-T4 (P <0.05); PT and TT decreased at T1-T3 (P <0.05); FIB and D-D decreased at T2-T4 (P<0.05). The occurrence of each complication was significantly lower in the treatment groups than in the control group. CONCLUSION: XI could improve the perioperative high @entity3459 state of senile @entity572 @entity1 , inhibit inflammatory reactions, and reduce complications.

title: [Effect of xuebijing injection on perioperative @entity3459 function and inflammatory reaction in senile XXXX receiving @entity572 ].

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To explore different regulatory effects of electroacupuncture (EA) at the same acupoint on the heart and the stomach. METHODS: Eighty male SD @entity35 were randomly divided into eight groups equally, i.e., the Neiguan ( @entity16518 ) group, the Quchi (LI11) group, the Tianshu (ST25) group, the Danzhong (RN17) group, the Zusanli (ST36) group, the Sanyinjiao ( @entity38337 ) group, the Xinshu (BL15) group, and the Weishu (BL21) group, 10 in each group. The regulatory effects of EA (2/15 Hz, 3 mA, 2 min) at different acupoints on the gastric motility (intragastric pressure) and the cardiac function (the left ventricular pressure) were observed. The mean values of effect of two-min pre-EA and after-EA were compared. RESULTS: Compared with the pre-EA in the same group, the left ventricular pressure decreased in the Neiguan ( @entity16518 ) group, the Quchi (LI11) group, the Danzhong (RN17) group, the Sanyinjiao ( @entity38337 ) group, and the Xinshu (BL15) group (P <0.05). The intragastric pressure increased in the Quchi (LI11) group, the Zusanli (ST36) group, the Sanyinjiao ( @entity38337 ) group, and the Xinshu (BL15) group, while it decreased in the Tianshu (ST25) group, the Danzhong (RN17) group, and the Weishu (BL21) group (P <0.05). The difference of the left ventricular pressure was sequenced from high to low as Xinshu (BL15) >Danzhong (RN17) >Neiguan ( @entity16518 ) >Sanyinjiao ( @entity38337 ) >Quchi (LI11). The difference of the intragastric pressure was sequenced from high to low as Tianshu (ST25) >Weishu (BL21) > Xinshu (BL15) > Danzhong (RN17) > Zusanli (ST36) > Sanyinjiao ( @entity38337 ) > Quchi (LI11). CONCLUSIONS: EA at the same acupoint (2/15 Hz, 3 mA) showed different regulatory effects on the heart and stomach. There existed some difference in the direction and size due to the acupoint location, meridians, dominant nerve segment or relating organs. A fixed effect direction to the specific target was also shown.

title: [Regulatory effect of electroacupuncture on heart and stomach of XXXX ].

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: @entity5406 ( @entity5406 ) is an immune complex-mediated reaction that may complicate the course of @entity1202 . @entity4530 in @entity1605 , though reported, are exceedingly rare. We report the case of a 32 year old female @entity1 who presented initially at our OPD with @entity5406 . Cutaneous examination revealed @entity1183 over dorsum of right foot and thickened right lateral popliteal nerve. Slit skin smear (SSS) from ear lobes revealed AFB with a bacteriological index of 2+. She was started on MDT, tablet @entity800 200 mg twice a day, and 30 mg oral @entity617 . Two months later, she presented with generalised @entity111 , large target lesions over the back, and @entity548 over lower extremities and annular pattern of bullae, over both arms. A SSS was repeated which was positive for AFB. Histopathology from @entity4530 was consistent with @entity5406 . Direct Immunofluorescence (DIF) study was negative. Our @entity1 improved rapidly after she was started on @entity2816 100 mg twice daily, with withdrawal of @entity800 . @entity9374 ( @entity9374 ) and annular @entity4530 have been reported in @entity1 on treatment with @entity800 . This case is being presented due to the unusual and varied manifestation of @entity1605 in a 34 year old female @entity1 .

title: Annular @entity4530 with atypical XXXX in leprosy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['Type II reaction', 'Type II lepra reaction']

entities_list: @entity1183 :: ('MESH:D006987', 'Disease') :: ['impaired sensation']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic bullae']

entities_list: @entity4530 :: ('MESH:D001768', 'Disease') :: ['Bullous lesions', 'bullous lesions']

entities_list: @entity2816 :: ('MESH:D013792', 'Chemical') :: ['thalidomide']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity1202 :: ('MESH:D056006', 'Disease') :: ['multibacillary leprosy']

entities_list: @entity617 :: ('MESH:D011239', 'Chemical') :: ['prednisolone']

entities_list: @entity800 :: ('MESH:D015242', 'Chemical') :: ['ofloxacin']

entities_list: @entity5406 :: ('MESH:D004893', 'Disease') :: ['Erythema nodosum leprosum', 'erythema nodosum', 'ENL']

entities_list: @entity9374 :: ('MESH:D004892', 'Disease') :: ['Erythema Multiforme', 'EMF']

answer: @entity9374 :: (MESH:D004892,Disease) :: ['erythema multiforme']


abstract: @entity5406 ( @entity5406 ) is an immune complex-mediated reaction that may complicate the course of @entity1202 . @entity4530 in @entity1605 , though reported, are exceedingly rare. We report the case of a 32 year old female @entity1 who presented initially at our OPD with @entity5406 . Cutaneous examination revealed @entity1183 over dorsum of right foot and thickened right lateral popliteal nerve. Slit skin smear (SSS) from ear lobes revealed AFB with a bacteriological index of 2+. She was started on MDT, tablet @entity800 200 mg twice a day, and 30 mg oral @entity617 . Two months later, she presented with generalised @entity111 , large target lesions over the back, and @entity548 over lower extremities and annular pattern of bullae, over both arms. A SSS was repeated which was positive for AFB. Histopathology from @entity4530 was consistent with @entity5406 . Direct Immunofluorescence (DIF) study was negative. Our @entity1 improved rapidly after she was started on @entity2816 100 mg twice daily, with withdrawal of @entity800 . @entity9374 ( @entity9374 ) and annular @entity4530 have been reported in @entity1 on treatment with @entity800 . This case is being presented due to the unusual and varied manifestation of @entity1605 in a 34 year old female @entity1 .

title: Annular XXXX with atypical @entity9374 in leprosy.

answer: @entity4530 :: (MESH:D001768,Disease) :: ['bullous lesions']


abstract: Cell surface pellicular membranes (PM) were isolated from promastigote forms of @entity3911 by differential and discontinuous @entity969 gradient centrifugation procedures. The PM had a density equivalent of approximately 1.19 g/cm3. As ascertained by electron microscopy, longitudinal parallel arrays of subpellicular microtubules (MT) remained attached to the isolated PM inner lamina, and this feature was used to assess membrane fraction purity. Gradient fractions having greater than or equal to 95% of all membranes combined with MT were obtained routinely. The attached MT imparted a structural asymmetry to the PM permitting uniequivocal identification of the membrane external and cytoplasmic surfaces. The supramolecular structure of attached MT was evident in negatively stained PM. In ultrathin sections, PM had a mean width of approximately 7.2 nm and attached MT a diameter of approximately 29 nm. The MT were apparently cross-bridged both to each other and to the PM via a flocculent filamentoid nexus. As determined by @entity3208 - @entity2975 gel electrophoresis, isolated PM contained approximately 40 peptide bands ranging in apparent molecular weight from less than or equal 1.2 x 10(4) to greater than or equal to 2.2 x 10(5) daltons. Of these, 19 were stained with @entity5644 -Schiffs' reagent suggesting that most PM @entity1735 constituents were present as glycopeptides. A presumpative glycolipid!polysaccharide PM constituent was also identified in such gels.

title: Isolation and partial characterization of surface membranes from XXXX promastigotes.

entities_list: @entity5644 :: ('MESH:D010504', 'Chemical') :: ['periodic acid']

entities_list: @entity3208 :: ('MESH:D012967', 'Chemical') :: ['sodium dodecylsulfate']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity3911 :: ('5661', 'Species') :: ['Leishmania donovani']

answer: @entity3911 :: (5661,Species) :: ['Leishmania donovani']


abstract: The aim is to present a case of @entity17390 in the periocular area in a 10-year-old female through retrospective review of medical records of a single @entity1 . A 10-year-old female developed a lesion under her right eyebrow over a period of one year. The rest of the ophthalmic history was unremarkable. On examination, oval, well-defined, subcutaneous @entity5 measuring 7 x 4 mm was found under the right eyebrow. It gave bluish tint under the firmly adherent overlying skin of normal color and texture. Rocky hard and non-tender, it was mobile over the underlying tissues. Total excision biopsy was performed under general anesthesia. Histopathologic analysis confirmed the diagnosis ofpilomatrixoma. @entity17390 is a rare @entity5 with head, neck and periocular area being the commonest sites. It is often clinically misdiagnosed and/or missed on differential diagnosis. Although a @entity5 , malignant transformation into @entity189 has been described. Thus, total surgical excision of the mass is recommended.

title: Periocular XXXX : case report.

entities_list: @entity17390 :: ('MESH:D018296', 'Disease') :: ['Pilomatrixoma', 'pilomatrixoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['pilomatrix carcinoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'benign tumor']

answer: @entity17390 :: (MESH:D018296,Disease) :: ['pilomatrixoma']


abstract: OBJECTIVE: To investigate the effect of triptolide (TPL) on the renal tissue of @entity6 @entity35 and its possible mechanisms. METHODS: SD @entity35 were randomly divided into the normal control group (as the normal group), the @entity6 model group (the model group), the low dose TPL treatment group (the low dose TPL group, TPL 0.2 mg/kg by gastrogavage), the high dose TPL treatment group (the high dose TPL group, TPL 0.4 mg/kg by gastrogavage). Equal volume of normal saline was given to @entity35 in the normal group and the model group. Five @entity35 were randomly selected from each group at week 4, 8, and 12 of the experiment to detect body weight, kidney weight, 24 h urinary albumin (24 h UAL), plasma glucose (FBG), total cholesterol (TC), total triglyeride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), white blood cell (WBC), and hemoglobin A1c (HbA1c). The mRNA and protein expression of @entity16620 ( @entity16620 ) in the renal tissue was assessed by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA). The renal tissue was pathologically stained by HE, PAS, and Masson staining. The glomerular and renal tubular interstitial lesions were observed at each time point. The @entity8 index (GSI) was observed by PAS staining, and the @entity8 ( @entity8 ) was calcutated. RESULTS: Compared with the same group at week 4, the expression of 24 h UAL, @entity16620 , GSI, and @entity8 at week 12 significantly decreased in two TPL groups (P <0.01). Compared with the same group at week 8, the expression of 24 h UAL, @entity16620 , GSI, and @entity8 at week 12 also significantly decreased in the two TPL groups (P <0. 05, P <0.01). Compared with the normal group, body weight and the kidney weight obviously decreased at week 4, 8, and 12 in the model group (P <0. 01); 24 h UAL, FBG, TG, TC, HbA1c, @entity16620 , GSI, and @entity8 were obviously elevated (P <0.01). Compared with the model group, 24 h UAL, @entity16620 , GSI, and @entity8 also decreased in the two TPL treatment groups (P <0.01). Compared with the low dose TPL group, they were attenuated in the high dose TPL group (P <0. 05, P <0. 01). CONCLUSION: TPL could not only inhibit the over-expression of @entity16620 , but also improve the @entity8 and @entity8 in the renal tissue of @entity6 @entity35 .

title: [Effect of triptolide on the expression of XXXX in the renal tissue of diabetic nephropathy @entity35 ].

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal interstitial filrosis index', 'RIFI', 'renal interstitial fibrosis', 'glomerular sclerosis']

entities_list: @entity16620 :: ('81780(Tax:10116)', 'Gene') :: ['regulated upon activation normal T-cell expressed and secreted', 'RANTES']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

answer: @entity16620 :: (81780(Tax:10116),Gene) :: ['RANTES']


abstract: OBJECTIVE: To investigate the effect of triptolide (TPL) on the renal tissue of @entity6 @entity35 and its possible mechanisms. METHODS: SD @entity35 were randomly divided into the normal control group (as the normal group), the @entity6 model group (the model group), the low dose TPL treatment group (the low dose TPL group, TPL 0.2 mg/kg by gastrogavage), the high dose TPL treatment group (the high dose TPL group, TPL 0.4 mg/kg by gastrogavage). Equal volume of normal saline was given to @entity35 in the normal group and the model group. Five @entity35 were randomly selected from each group at week 4, 8, and 12 of the experiment to detect body weight, kidney weight, 24 h urinary albumin (24 h UAL), plasma glucose (FBG), total cholesterol (TC), total triglyeride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST), white blood cell (WBC), and hemoglobin A1c (HbA1c). The mRNA and protein expression of @entity16620 ( @entity16620 ) in the renal tissue was assessed by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme linked immunosorbent assay (ELISA). The renal tissue was pathologically stained by HE, PAS, and Masson staining. The glomerular and renal tubular interstitial lesions were observed at each time point. The @entity8 index (GSI) was observed by PAS staining, and the @entity8 ( @entity8 ) was calcutated. RESULTS: Compared with the same group at week 4, the expression of 24 h UAL, @entity16620 , GSI, and @entity8 at week 12 significantly decreased in two TPL groups (P <0.01). Compared with the same group at week 8, the expression of 24 h UAL, @entity16620 , GSI, and @entity8 at week 12 also significantly decreased in the two TPL groups (P <0. 05, P <0.01). Compared with the normal group, body weight and the kidney weight obviously decreased at week 4, 8, and 12 in the model group (P <0. 01); 24 h UAL, FBG, TG, TC, HbA1c, @entity16620 , GSI, and @entity8 were obviously elevated (P <0.01). Compared with the model group, 24 h UAL, @entity16620 , GSI, and @entity8 also decreased in the two TPL treatment groups (P <0.01). Compared with the low dose TPL group, they were attenuated in the high dose TPL group (P <0. 05, P <0. 01). CONCLUSION: TPL could not only inhibit the over-expression of @entity16620 , but also improve the @entity8 and @entity8 in the renal tissue of @entity6 @entity35 .

title: [Effect of triptolide on the expression of @entity16620 in the renal tissue of diabetic nephropathy XXXX ].

answer: @entity35 :: (10116,Species) :: ['rats']