abstract: @entity1356 is a potent inhibitor of gastric acid secretion and its genetic polymorphism is linked to the severity of @entity354 . Proton-pump inhibitor (PPI) metabolized by P450 2C19 ( @entity4433 ) is the chief medication in @entity354 treatment. The @entity4433 genotype may influence the therapeutic effect of PPI for @entity354 . From November 2009 to June 2012, 184 @entity1 were enrolled in this study with endoscopy examination, 8 weeks of esomeprazole treatment, and 20 weeks of follow-up with questionnaire. These @entity1 also received endoscopy examination after 20 weeks. Blood was collected for genetic polymorphism analysis with polymerase chain reaction. After 8 weeks of treatment with esomeprazole, all of these 184 @entity1 had achieved complete symptom relief. However, in the following 12 weeks, 58.70% (108/184) complained of symptom relapse, 45.65% (84/184) @entity1 had persistent esophageal erosion verified by endoscopy, and in total, 76.09% (140/184) @entity1 had treatment failure at the end of 20 weeks. There were no influences between the genetic polymorphisms of @entity4433 and @entity1356 to treatment failure (p = 0.896). Therefore, prolonging PPI treatment and further lifestyle modification might be warranted for symptomatic mild @entity2910 . There were no relationships between @entity1356 and @entity4433 in the treatment effect in mild @entity354 .

title: Genetic polymorphisms of @entity4433 and @entity1356 have no influence on esomeprazole treatment for mild XXXX .

answer: @entity2910 :: (MESH:D004941,Disease) :: ['erosive esophagitis']


abstract: @entity1356 is a potent inhibitor of gastric acid secretion and its genetic polymorphism is linked to the severity of @entity354 . Proton-pump inhibitor (PPI) metabolized by P450 2C19 ( @entity4433 ) is the chief medication in @entity354 treatment. The @entity4433 genotype may influence the therapeutic effect of PPI for @entity354 . From November 2009 to June 2012, 184 @entity1 were enrolled in this study with endoscopy examination, 8 weeks of esomeprazole treatment, and 20 weeks of follow-up with questionnaire. These @entity1 also received endoscopy examination after 20 weeks. Blood was collected for genetic polymorphism analysis with polymerase chain reaction. After 8 weeks of treatment with esomeprazole, all of these 184 @entity1 had achieved complete symptom relief. However, in the following 12 weeks, 58.70% (108/184) complained of symptom relapse, 45.65% (84/184) @entity1 had persistent esophageal erosion verified by endoscopy, and in total, 76.09% (140/184) @entity1 had treatment failure at the end of 20 weeks. There were no influences between the genetic polymorphisms of @entity4433 and @entity1356 to treatment failure (p = 0.896). Therefore, prolonging PPI treatment and further lifestyle modification might be warranted for symptomatic mild @entity2910 . There were no relationships between @entity1356 and @entity4433 in the treatment effect in mild @entity354 .

title: Genetic polymorphisms of @entity4433 and XXXX have no influence on esomeprazole treatment for mild @entity2910 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['reflux esophagitis']

answer: @entity1356 :: (3553,Gene) :: ['IL1B']


abstract: PURPOSE: An unmet clinical need in @entity0 management is the accurate identification of @entity1 who will benefit from adjuvant radiotherapy. We hypothesized that integration of postradiation clonogenic survival data with gene expression data across @entity0 cell (BCC) lines would generate a @entity1161 ( @entity1161 ) and identify @entity1 with @entity5 refractive to conventional therapy. EXPERIMENTAL DESIGN: Using clonogenic survival assays, we identified the surviving fraction (SF-2Gy) after radiation across a range of BCC lines. Intrinsic radiosensitivity was correlated to gene expression using Spearman correlation. Functional analysis was performed in vitro, and enriched biologic concepts were identified. The @entity1161 was generated using a Random Forest model and was refined, cross-validated, and independently validated in additional @entity0 datasets. RESULTS: Clonogenic survival identifies a range of radiosensitivity in @entity1 BCC lines (SF-2Gy 77%-17%) with no significant correlation to the @entity0 subtypes. One hundred forty-seven genes were correlated with radiosensitivity. Functional analysis of @entity1161 genes identifies previously unreported radioresistance-associated genes. @entity1161 was trained, cross-validated, and further refined to 51 genes that were enriched for concepts involving cell-cycle arrest and DNA damage response. @entity1161 was validated in an independent dataset and was the most significant factor in predicting local recurrence on multivariate analysis, outperfoming all clinically used clinicopathologic features. CONCLUSIONS: We derive a @entity1 @entity0 -specific @entity1161 with biologic relevance and validate this signature for prediction of locoregional recurrence. By identifying @entity1 with @entity5 refractory to standard radiation this signature has the potential to allow for personalization of radiotherapy.

title: Development and Validation of a Novel Radiosensitivity Signature in @entity1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'intrinsic breast cancer']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['radiation sensitivity signature', 'RSS']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']


abstract: PURPOSE: An unmet clinical need in @entity0 management is the accurate identification of @entity1 who will benefit from adjuvant radiotherapy. We hypothesized that integration of postradiation clonogenic survival data with gene expression data across @entity0 cell (BCC) lines would generate a @entity1161 ( @entity1161 ) and identify @entity1 with @entity5 refractive to conventional therapy. EXPERIMENTAL DESIGN: Using clonogenic survival assays, we identified the surviving fraction (SF-2Gy) after radiation across a range of BCC lines. Intrinsic radiosensitivity was correlated to gene expression using Spearman correlation. Functional analysis was performed in vitro, and enriched biologic concepts were identified. The @entity1161 was generated using a Random Forest model and was refined, cross-validated, and independently validated in additional @entity0 datasets. RESULTS: Clonogenic survival identifies a range of radiosensitivity in @entity1 BCC lines (SF-2Gy 77%-17%) with no significant correlation to the @entity0 subtypes. One hundred forty-seven genes were correlated with radiosensitivity. Functional analysis of @entity1161 genes identifies previously unreported radioresistance-associated genes. @entity1161 was trained, cross-validated, and further refined to 51 genes that were enriched for concepts involving cell-cycle arrest and DNA damage response. @entity1161 was validated in an independent dataset and was the most significant factor in predicting local recurrence on multivariate analysis, outperfoming all clinically used clinicopathologic features. CONCLUSIONS: We derive a @entity1 @entity0 -specific @entity1161 with biologic relevance and validate this signature for prediction of locoregional recurrence. By identifying @entity1 with @entity5 refractory to standard radiation this signature has the potential to allow for personalization of radiotherapy.

title: Development and Validation of a Novel Radiosensitivity Signature in XXXX @entity0 .

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: PURPOSE: To report a new case of @entity189 . The clinical and pathological characteristics of the lesion and a review of the literature are both described. METHODS: A descriptive study of a case of invasive CHC occurring in a 60-yr-old @entity1 is presented. @entity5 was standard processed and stained by @entity1710 _ @entity1711 , PAS, immunohistochemically examined for ER, PR, @entity1722 , @entity10580 , thyroglobulin, @entity5962 , @entity4483 protein, and @entity4205 /6. RESULTS: The @entity5 , which was 4.7*3.7*3.0 cm, was localized in the upper region of the left breast. This @entity5 revealed multiple cystic spaces, which were filled with PAS. It was positive for @entity10580 , ER, @entity5962 , and @entity4483 protein, but negative for thyroglobulin, PR, and @entity1722 . @entity4205 was expressed in the @entity1373 region, but not in the invasive area. The ten-month follow-up period was uneventful. CONCLUSIONS: @entity0 is a rare and distinctive variant of @entity513 in situ. It has the potential for invasive growth. As there are few recorded cases, the prognosis in @entity1 with invasive CHC is still uncertain and a matter of intensive debate.

title: Invasive XXXX : a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Cystic hypersecretory carcinoma of the breast']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity1373 :: ('MESH:D006965', 'Disease') :: ['cystic hypersecretory hyperplasia']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive cystic hypersecretory carcinoma']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity4205 :: ('3852', 'Gene') :: ['Cytokeratin5/6', 'Cytokeratin5']

answer: @entity0 :: (MESH:D001943,Disease) :: ['cystic hypersecretory carcinoma of the breast']


abstract: @entity361 mixed connective tissue variant (PMTMCT) is a rare @entity5 occurring in bone and soft tissue that usually behaves in a benign manner. Elaboration of biologically active substances by this @entity5 gives rise to a @entity8231 known as @entity4771 , manifesting clinically as @entity158 , generalized weakness and @entity174 . Recognition of PMTMCT and its associated syndrome is important, as resection of the @entity5 in most instances results in prompt resolution of symptoms. Previously reported cases of this @entity5 have emphasized the consistent presence of certain histological features that are considered prerequisite for making the diagnosis of PMTMCT. We describe three cases of PMTMCT, of which two first presented with progressive symptoms of @entity4772 and one remained clinically silent aside from the symptom of a palpable lump. Our cases highlight the wide-ranging histological patterns displayed by these @entity5 , and draw attention to certain microscopic findings that until now have been given little if any mention. Tentacular growth pattern and satellite nodules appear to be common findings in PMTMCTs, and can make complete surgical excision of these @entity5 challenging. The ability of this otherwise histologically benign @entity5 to permeate vascular spaces has to our knowledge never been described previously. One @entity5 lacked the characteristic calcifying matrix of PMTMCT, suggesting that in some @entity5 this defining feature may be focal if not entirely absent. PMTMCT shares features with and can resemble a variety of @entity2721 , requiring the surgical pathologist to be familiar with this entity.

title: XXXX mixed connective tissue variant: report of three cases with unusual histological findings.

entities_list: @entity4772 :: ('MESH:D010018', 'Disease') :: ['osteomalacia']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['pathological fractures']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity4771 :: ('MESH:C537751', 'Disease') :: ['oncogenic osteomalacia']

entities_list: @entity2721 :: ('MESH:D018213', 'Disease') :: ['bone and soft tissue neoplasms']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['bone pain']

entities_list: @entity8231 :: ('MESH:D010257', 'Disease') :: ['paraneoplastic syndrome']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['Phosphaturic mesenchymal tumour']

answer: @entity361 :: (MESH:C535700,Disease) :: ['Phosphaturic mesenchymal tumour']


abstract: @entity3074 is a common benign @entity5 with many clinicopathological variants. @entity3074 is one of these variants, which is characterized by marked stromal mucin deposition. This report presents a case of @entity3074 on a great toe that had been slowly growing for two years. Histopathologically, the relatively well-circumscribed @entity5 was separated from the epidermis by a small grenz zone. The @entity5 tissue consisted of oval to spindle-shaped cells with well-defined cell borders and spindly condensed nuclei. No cytologic atypia or mitotic figures were found. Although most of the @entity5 cells were embedded in a prominently myxoid stroma, typical features of classic @entity3074 including a storiform growth pattern and more densely packed collagen were observed at the periphery. Immunohistochemically, the @entity5 cells showed positive staining for @entity469 and @entity3778 , and negative staining for @entity2280 and @entity4483 . Histopathological differential diagnoses of @entity3074 include @entity8650 with myxoid @entity5 stroma, such as superficial acral @entity81 , cellular digital fibroma, @entity3291 , @entity241 protuberans and low-grade @entity242 . Immunohistochemical staining can be useful in the differential diagnosis of these @entity5 . This case highlights the challenges encountered in the histopathological interpretation of @entity3074 . Pathologists should keep in mind the diagnosis of @entity3074 when dealing with @entity1313 arising on acral sites.

title: XXXX on a great toe: a case report.

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['fibromyxoid sarcoma']

entities_list: @entity8650 :: ('MESH:D012983', 'Disease') :: ['soft tissue neoplasms']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['fibrohistiocytic tumor', 'tumor', 'dermal tumor', 'tumors']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['myxoid neoplastic lesions']

entities_list: @entity241 :: ('MESH:D018223', 'Disease') :: ['myxoid dermatofibrosarcoma']

entities_list: @entity3291 :: ('MESH:D009232', 'Disease') :: ['superficial angiomyxoma']

entities_list: @entity3074 :: ('MESH:D018219', 'Disease') :: ['Myxoid dermatofibroma', 'myxoid dermatofibroma', 'dermatofibroma', 'Dermatofibroma']

entities_list: @entity81 :: ('MESH:D005350', 'Disease') :: ['fibromyxoma']

answer: @entity3074 :: (MESH:D018219,Disease) :: ['Myxoid dermatofibroma']


abstract: BACKGROUND: platelet-rich-plasma is increasingly used in @entity924 . Ideal number of @entity3669 injections needed is not yet established. This study compares the clinical outcomes of a single versus two consecutive @entity3669 injections. METHOD: between December 2009 and January 2012, 40 athletes with @entity924 were treated by @entity3669 injection. @entity1 received single (20 @entity1 ) or two @entity3669 injections 2 weeks apart (20 @entity1 ). All @entity1 underwent prospective clinical evaluation, including Victorian Institute of Sport Assessment-Patella (VISA-P) score, visual analog scale (VAS) for @entity158 , and Tegner scale before @entity3669 and after a minimum of 2 year follow-up. RESULTS: 9 @entity1 failed @entity3669 treatment and needed surgery. 1 @entity1 was lost to follow-up. For the remaining @entity1 , the VISA-P, VAS, and Tegner scores all significantly improved from 35.2 to 78.5 (p = 0.0001), 6.6 to 2.4 (p = 0.0001), and 4.8 to 6.9 (p = 0.0003). @entity1 who received two injections had better scores than those who received single injection with VAS of 1.07 versus 3.7 (p = 0.0005), Tegner score of 8.1 versus 5.9 (p = 0.0003) and VISA-P of 93.2 versus 65.7 (p = 0.0001). CONCLUSIONS: two consecutive @entity3669 injections in @entity924 showed better improvement in outcomes when compared to single injection. LEVEL OF EVIDENCE: randomized prospective consecutive series, Level 2.

title: Platelet-rich plasma as a treatment for XXXX : comparison of a single versus two consecutive injections.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['proximal patellar tendinopathy', 'chronic patellar tendinopathy']

answer: @entity924 :: (MESH:D052256,Disease) :: ['chronic patellar tendinopathy']


abstract: BACKGROUND: The association between b2-adrenergic receptor ( @entity2162 ) -16Arg/ @entity4022 polymorphism ( @entity72113 ) and @entity1030 ( @entity1030 ) risk has been investigated in many published studies. However, the results were inconclusive. A meta-analysis was performed to make a more precise estimation of the relationship. METHODS: The PubMed, EMBASE, ISI web of science, the Cochrane Database of Systematic Reviews, and Chinese databases (CNKI, Wanfang Data, CBM, @entity3549 ) were searched for published literature. Odds ratios (OR) with 95% confidence interval (CI) were used to assess the strength of association. RESULTS: Eleven studies, comprising 1,128 @entity1030 @entity1 and 1,182 controls, were included in the meta-analysis. Overall, there was no significant association between the @entity2162 -16Arg/ @entity4022 polymorphism and @entity1030 risk in general population. In the stratification analysis by potential confounding variables, significant associations were observed between the @entity2162 -16Arg/ @entity4022 polymorphism and @entity1030 risk among smoking Asians under the dominant genetic model and allele model ( @entity534 vs. @entity4022 ) (dominant model: OR = 1.45, 95% CI = 1.04-2.01, P = 0.311 for heterogeneity, z = 2.22, P = 0.026 for OR; allele model: OR = 1.27, 95% CI = 1.03-1.57, P = 0.209 for heterogeneity, z = 2.20, P = 0.028 for OR), but not in other subgroups. CONCLUSION: This meta-analysis suggested that the @entity2162 -16Arg/ @entity4022 polymorphism might be a potential risk factor for the development of @entity1030 in smoking Asian populations, but not in European descendents, and @entity286 smoking probably increased the genetic susceptibility. More studies with larger sample sizes are needed to validate the results.

title: Association between b2-Adrenergic Receptor-16Arg/ XXXX Gene Polymorphism and Chronic Obstructive Pulmonary Disease Risk:Systematic Review and Meta-Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive pulmonary disease', 'COPD']

answer: @entity4022 :: (MESH:C066286,Chemical) :: ['Gly']


abstract: Two forms of a DNA polymerase have been purified from microplasmodia of @entity9417 by @entity10849 precipitation and chromatography on DEAE-Sephacel, phosphocellulose, heparin @entity3367 , @entity692 , DNA-agarose, blue-Sepharose. They were separated from DNA polymerase alpha on phosphocellulose and from each other on heparin-Sepharose. Form HS1 enzyme was 30-40% pure and form HS2 enzyme 60% with regard to protein contents of the preparations. Form HS2 enzyme was generated from form HS1 enzyme on prolonged standing of enzyme preparations. The DNA polymerases were obtained as complexes of a 60-kDa protein associated with either a 135-kDa (HS1) or a 110-kDa (HS2) DNA-polymerizing polypeptide in a 1:1 molar stoichiometry. The biochemical function of the 60-kDa protein remained unknown. The complexes tended to dissociate during gradient centrifugation and during partition chromatography as well as during @entity2975 gradient gel electrophoresis under nondenaturing conditions at high dilutions of samples. Both forms existed in plasmodia extracts, their proportions depending on several factors including those which promoted proteolysis. The DNA polymerases resembled eucaryotic DNA polymerase beta by several criteria and were functionally indistinguishable from each other. It is suggested that lower eucaryotes contain repair DNA polymerases, which are similar to those of eubacteria on a molecular mass basis.

title: A DNA polymerase with unusual properties from the slime mold XXXX .

entities_list: @entity9417 :: ('5791', 'Species') :: ['Physarum polycephalum']

entities_list: @entity10849 :: ('MESH:D011094|MESH:C505405', 'Chemical') :: ['poly(ethyleneimine)']

entities_list: @entity692 :: ('MESH:D017886', 'Chemical') :: ['hydroxyapatite']

entities_list: @entity2975 :: ('CHEBI:51135', 'Chemical') :: ['polyacrylamide']

entities_list: @entity3367 :: ('MESH:D012685', 'Chemical') :: ['Sepharose']

answer: @entity9417 :: (5791,Species) :: ['Physarum polycephalum']


abstract: The preliminary results of a prospective study undertaken in @entity1 with a first episode of @entity583 are presented. The clinical, electrocardiographic and angiographic characteristics of 34 @entity1 who developed early post- @entity1188 angina (group I) were compared with those of 144 @entity1 who remained asymptomatic after the acute @entity1188 (group II). No difference was found between the two groups as to age, sex prevalence, risk factors, presence of @entity5749 before @entity1188 , severe @entity943 or transient @entity712 in CCU and peak CK value. @entity1 of group I had more frequently ecg signs of @entity583 in anterior leads (P less than 0.01) than @entity1 of group II. Exercise testing, performed by 23 @entity1 of group I and by 140 @entity1 of group II, was positive in 14 @entity1 with early post- @entity1188 angina and in 37 who remained asymptomatic after the acute @entity1188 (P less than 0.01). The two groups had similar values of left ventricular end diastolic volume index, left ventricular end diastolic pressure and ejection fraction. @entity1 with early post- @entity1188 angina however had more frequently double or @entity66 , while single vessel disease prevailed in group II @entity1 . Although the follow-up period was limited (average 9 months), a higher incidence of @entity299 was found in group I @entity1 (P less than 0.01). These data show that early post- @entity1188 angina defines a high-risk subset of @entity1 among those with recent @entity583 . A more @entity146 approach, including thrombolytic therapy and coronary angioplasty, seems warranted.

title: Clinical and angiographic data in early post- XXXX angina.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['triple vessel disease']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive']

entities_list: @entity5749 :: ('MESH:D060050', 'Disease') :: ['stable angina']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct', 'infarction']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac complications']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'acute myocardial infarction']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias']

answer: @entity1188 :: (MESH:D007238,Disease) :: ['infarction']


abstract: Serum IgE concentration was measured on the 5th day of life in 943 @entity1 . All @entity1 were included in a 3 month follow-up study. The frequency of @entity291 's @entity6132 was studied according to either family history, IgE level, or both. Feeding (mother's milk or formula feeding) was taken into account. Manifestations suggestive of @entity5419 were hardly observed in breast-fed babies. In the formula-fed group a positive family history correlated with a 40% incidence of @entity56 manifestations, compared to a 13% incidence (P less than 0.001) in the group with negative family history. A high IgE level (IgE greater than 1.3 U/ml) indicated a 43% risk of developing @entity56 manifestations in formula-fed babies as compared to 15% (P less than 0.001) in the group with normal results of a screening test. Frequency of @entity56 manifestations in a subgroup with a negative family history and a high IgE level (38%) was equal to the frequency in the subgroup with a positive family history and negative screening test results (IgE less than 1.3 U/ml)(36%). The incidence in the subgroup with both positive screening test results and a positive family history was 49%. None of these differences were significant. The frequency in the subgroup with both parameters negative was 8% (P less than 0.001 to 3 other subgroups). Our results indicate that the family history seems to correlate as well with the incidence of @entity56 manifestations as the neonatal serum IgE concentration.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Influences of neonatal serum IgE concentration, family history and diet on the incidence of XXXX 's @entity6132 .

entities_list: @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy']

entities_list: @entity6132 :: ('MESH:D016269', 'Disease') :: ['milk allergy']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic']

answer: @entity291 :: (9913,Species) :: ['cow']


abstract: Serum IgE concentration was measured on the 5th day of life in 943 @entity1 . All @entity1 were included in a 3 month follow-up study. The frequency of @entity291 's @entity6132 was studied according to either family history, IgE level, or both. Feeding (mother's milk or formula feeding) was taken into account. Manifestations suggestive of @entity5419 were hardly observed in breast-fed babies. In the formula-fed group a positive family history correlated with a 40% incidence of @entity56 manifestations, compared to a 13% incidence (P less than 0.001) in the group with negative family history. A high IgE level (IgE greater than 1.3 U/ml) indicated a 43% risk of developing @entity56 manifestations in formula-fed babies as compared to 15% (P less than 0.001) in the group with normal results of a screening test. Frequency of @entity56 manifestations in a subgroup with a negative family history and a high IgE level (38%) was equal to the frequency in the subgroup with a positive family history and negative screening test results (IgE less than 1.3 U/ml)(36%). The incidence in the subgroup with both positive screening test results and a positive family history was 49%. None of these differences were significant. The frequency in the subgroup with both parameters negative was 8% (P less than 0.001 to 3 other subgroups). Our results indicate that the family history seems to correlate as well with the incidence of @entity56 manifestations as the neonatal serum IgE concentration.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Influences of neonatal serum IgE concentration, family history and diet on the incidence of @entity291 's XXXX .

answer: @entity6132 :: (MESH:D016269,Disease) :: ['milk allergy']


abstract: UNASSIGNED: Benthic bivalves are important links between primary production and consumers, and are essential intermediates in the flow of energy through estuarine systems. However, information on the diet of filter feeding bivalves in estuarine ecosystems is uncertain, as estuarine waters contain particulate matter from a range of sources and as bivalves are opportunistic feeders. We surveyed bivalves at different distances from the @entity2133 at the Yangtze estuarine marsh in winter and summer, and analyzed trophic dynamics using stable isotope (SI) and @entity844 (FA) techniques. Different bivalve species had different spatial distributions in the estuary. Glauconome chinensis mainly occurred in marshes near the @entity2133 , while @entity72114 preferred the creek. Differences were found in the diets of different species. @entity72114 consumed more diatoms and bacteria than @entity32544 , while @entity32544 assimilated more macrophyte material. FA markers showed that plants contributed the most (38.86    4.25%) to particular organic matter (POM) in summer, while diatoms contributed the most (12.68    1.17%) during winter. Diatoms made the largest contribution to the diet of @entity72114 in both summer (24.73    0.44%) and winter (25.51    0.59%), and plants contributed no more than 4%. This inconsistency indicates seasonal changes in food availability and the active feeding habits of the bivalve. Similar FA profiles for @entity72114 indicated that the bivalve had a similar diet composition at different sites, while different   @entity7352 results suggested the diet was derived from different @entity505 sources (C4 plant Spartina alterniflora and C3 plant Phragmites australis and Scirpus mariqueter) at different sites. Species-specific and temporal and/or spatial variability in bivalve feeding may affect their ecological functions in intertidal marshes, which should be considered in the study of food webs and material flows in estuarine ecosystems.

title: Trophic Dynamics of Filter Feeding Bivalves in the Yangtze Estuarine Intertidal Marsh: Stable Isotope and XXXX Analyses.

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['creek mouth']

entities_list: @entity72114 :: ('98310', 'Species') :: ['S. constricta', 'Sinonovacula constricta']

answer: @entity844 :: (CHEBI:35366,Chemical) :: ['Fatty Acid']


abstract: UNASSIGNED: Background and purpose - Increased mortality after @entity173 is well documented. The mortality after hospitalization for @entity174 is unknown, even though these are common injuries. Here we determined mortality after hospitalization for @entity174 in @entity1 aged >= 16 years. @entity1 and methods - We collected data about the diagnosis code (ICD10), procedure code (NOMESCO), and 7 additional characteristics of 5,985 @entity1 admitted to the @entity130 ward of Central Finland Hospital between 2002 and 2008. During the study, 929 @entity1 and 753 @entity1 sustained an @entity174 . The @entity1 were followed up until the end of 2012. Mortality rates were calculated using data on the population at risk. Results - By the end of follow-up (mean duration 6 years), 179 @entity1 (19%) and 105 @entity1 (14%) had died. The standardized mortality ratio (SMR) for all @entity1 was 1.5 (95% CI: 1.4-1.7). The SMR was higher for @entity1 (2.1, CI: 1.7-2.5) than for @entity1 (1.3, CI: 1.1-1.5) (p < 0.001). The SMR decreased with advancing age, and the mortality rate was highest for @entity1 with humerus @entity174 . Interpretation - In @entity1 , the risk of death related to @entity174 was even higher than that reported previously for @entity173 . Compared to the general population, the SMR was double for humerus @entity174 @entity1 , whereas @entity174 had no effect on mortality.

title: Increased mortality after XXXX requiring inpatient care.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fracture']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture', 'wrist fracture', 'upper extremity fracture', 'proximal humerus fracture']

answer: @entity174 :: (MESH:D050723,Disease) :: ['upper extremity fracture']


abstract: OBJECTIVES: @entity285 consumption before bathing is listed as a risk factor for @entity944 in a bathtub, which occurs relatively frequently in Japan. This study aimed to clarify the epidemiology of @entity285 -related @entity204 in bathtubs. SUBJECTS: Among all autopsy cases that were performed at the Tokyo Medical Examiner's Office between 2009 and 2010 (N = 5635), 357 cases of @entity204 in a bathtub were evaluated. Data regarding age, sex, blood @entity1068 level, manner and. cause .of @entity204 , @entity285 consumption, and @entity285 -related @entity344 were extracted. The cases were divided into three groups according to their blood @entity1068 levels (no blood @entity1068 , low @entity1068 , and high @entity1068 ), and their data were compared. RESULTS: A large majority of the cases in all groups involved @entity1 who were 50-89 years old. The mean age of the high @entity1068 group (61.7 years) was significantly lower than.that of the control group (71.1 years; P < 0.01). In addition, the proportion of @entity1 was significantly higher in the low and high @entity1068 groups (70.1% and 75.5%, respectively), compared to that in the control group (55.9%; P < 0.05). Daily @entity285 consumption was significantly more common in the low and high @entity1068 groups (49.5% and 87.8%, respectively), compared to that in the control group (23.2%; P < 0.01). Furthermore, @entity285 -related @entity344 were more common in the low and high @entity1068 groups (26.8% and 63.3%, respectively), compared to that in the control group (4.3%; P < 0.01). CONCLUSIONS: Preventive strategies for reducing @entity285 -related @entity204 in bathtubs should target male habitual drinkers (middle-aged to seniors), especially @entity1 who have been diagnosed with @entity285 -related diseases.

title: Epidemiology of XXXX -related @entity204 while Bathing in a Bathtub.

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'patients', 'persons']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal diseases']

entities_list: @entity285 :: ('D000431', 'Chemical') :: ['alcohol', 'Alcohol']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

answer: @entity285 :: (D000431,Chemical) :: ['Alcohol']


abstract: OBJECTIVES: @entity285 consumption before bathing is listed as a risk factor for @entity944 in a bathtub, which occurs relatively frequently in Japan. This study aimed to clarify the epidemiology of @entity285 -related @entity204 in bathtubs. SUBJECTS: Among all autopsy cases that were performed at the Tokyo Medical Examiner's Office between 2009 and 2010 (N = 5635), 357 cases of @entity204 in a bathtub were evaluated. Data regarding age, sex, blood @entity1068 level, manner and. cause .of @entity204 , @entity285 consumption, and @entity285 -related @entity344 were extracted. The cases were divided into three groups according to their blood @entity1068 levels (no blood @entity1068 , low @entity1068 , and high @entity1068 ), and their data were compared. RESULTS: A large majority of the cases in all groups involved @entity1 who were 50-89 years old. The mean age of the high @entity1068 group (61.7 years) was significantly lower than.that of the control group (71.1 years; P < 0.01). In addition, the proportion of @entity1 was significantly higher in the low and high @entity1068 groups (70.1% and 75.5%, respectively), compared to that in the control group (55.9%; P < 0.05). Daily @entity285 consumption was significantly more common in the low and high @entity1068 groups (49.5% and 87.8%, respectively), compared to that in the control group (23.2%; P < 0.01). Furthermore, @entity285 -related @entity344 were more common in the low and high @entity1068 groups (26.8% and 63.3%, respectively), compared to that in the control group (4.3%; P < 0.01). CONCLUSIONS: Preventive strategies for reducing @entity285 -related @entity204 in bathtubs should target male habitual drinkers (middle-aged to seniors), especially @entity1 who have been diagnosed with @entity285 -related diseases.

title: Epidemiology of @entity285 -related XXXX while Bathing in a Bathtub.

answer: @entity204 :: (MESH:D003643,Disease) :: ['Death']


abstract: OBJECTIVE: To evaluate the clinical outcomes and complications of @entity6629 in treating @entity2720 . METHODS: From January 2011 to January 2013,45 @entity1 with @entity2720 were treated with @entity6629 . There were 35 males and 10 females with an average age of 30.5 (ranged from 19 to 60) years old. At the final follow-up, VAS, DASH, Constant-Murley criterion were used to evaluate shoulder function. RESULTS: All @entity1 were followed up from 15 to 36 months. No @entity531 , wound @entity281 and stress @entity174 were found,but 3 @entity1 had a re-dislocation. At the final follow-up,the mean VAS score was decreased from (5.7  1.6) preoperatively to postoperative (0.2  0.1); DASH score was significantly decreased from (19.6  4.3) preoperatively to (0.3  0.1) postoperatively; Constant-Murley score was improved from (34.4  4.3) before operation to (94.8   3.5) after operation. CONCLUSION: Clinical outcomes of treating @entity2720 with @entity6629 is satisfactory. However, re-dislocation is still the most common complication. Careful perioperative management is an important factor in preventing re-dislocation.

title: [Triple-Endobutton technique for the treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['Tossy type III acromioclavicular joint dislocation']

entities_list: @entity531 :: ('MESH:D013901', 'Disease') :: ['neurovascular injury']

entities_list: @entity6629 :: ('MESH:C535318', 'Disease') :: ['Triple-Endobutton plates']

answer: @entity2720 :: (MESH:D007592,Disease) :: ['Tossy type III acromioclavicular joint dislocation']


abstract: OBJECTIVE: To explore clinical characteristics and treatment of posterior @entity174 . METHODS: From January 2011 to January 2013,18 @entity1 with posterior Pilon fracures were treated. Among them, 13 were male and 5 were female, aged from 22 to 63 years old, with an average age of 46. All the @entity1 were @entity6044 . Open reduction and internal fixation were performed after swelling subsided, lateral malleolous and posterior @entity174 were exposured through lateral approach on healthy side, plates were used to fixed,screws or small plates were used to fix the posterior prominence of medial malleolus after changed to supine position. AOFAS scoring were applied to evaulate clinical effects. RESULTS: All @entity1 were followed up with an average of 22(ranged, 12 to 48)months. All @entity1 obtained satisfactory reset except one @entity1 . All factures were recovered well with an average healing of 11 weeks. According to AOFAS score at the final following up, 7 cases were excellent,2 cases were moderate, and the total score was 86.8  9.2. CONCLUSION: Posterior @entity174 is not rare in clinical, its mechanism of injury, traumatic anatomy, surgical procedure and prognosis are different from that of classical @entity1171 and @entity174 .

title: [Clinical observation of characteristic and treatment of posterior Pilon XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1171 :: ('MESH:D064386', 'Disease') :: ['ankle fracture']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['Pilon fracture']

entities_list: @entity6044 :: ('MESH:D005596', 'Disease') :: ['closed fractures']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: Objectives: To examine the association between the use of anticholinergic drugs and the health-related quality of life (HRQoL) among community-dwelling older adults with @entity303 . Methods: This was a retrospective, longitudinal, cohort study of older  adults aged 65 years and above diagnosed with @entity303 using Medical Expenditure Panel Survey data. Anticholinergic drug exposure was measured using the Anticholinergic Drug Scale. The HRQoL measures of interest were Physical Component Score (PCS) and @entity1032 ( @entity1032 ). Two separate unweighted multiple linear regression analyses were performed to determine the association of anticholinergic drugs with PCS and @entity1032 , while adjusting for other factors and baseline HRQoL measures. Results: The study included 112 @entity1 with @entity303 ; 15.18% of whom used anticholinergic drugs. The majority of the @entity1 were between the ages of 65 and 79 years (53%), @entity1 (57%), and  had poor or low family income (65%). After controlling for other factors and baseline HRQoL, anticholinergic drug use was associated with 7.48 unit reductions in PCS (P  <0.01), whereas no association was found between anticholinergic drug use and @entity1032 . Baseline HRQoL measures were found to be significant in both models. Conclusion: Anticholinergic drugs  are associated with reduced PCS of HRQoL in older adults with @entity303 . The study findings suggest the need for carefully monitoring the health status of elderly @entity1 when prescribing anticholinergic agents in this vulnerable population.

title: Anticholinergic drugs and health-related quality of life in older adults with XXXX .

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['MCS', 'Mental Component Score']

answer: @entity303 :: (MESH:D003704,Disease) :: ['dementia']


abstract: We have examined the effects of aging on the capacity of @entity35 uterine @entity53 receptors to be transformed from 8S to 4S and 5S species. Cytosol receptors from mature (6-month-old) @entity35 or senescent (24-month-old) @entity35 have been exposed to various @entity4338 concentrations, @entity1329 precipitation and 25 degrees C heating. @entity53 receptors of both the mature and senescent age groups exist in an 8S form on linear 5-20% @entity969 gradients in the absence of @entity4338 and are converted to a 4S molecule in the presence of 0.4 M @entity4338 . At intermediate salt concentrations a greater portion of mature receptors was converted to the 4S species. At 0.15 M @entity4338 62.3% +/- 2.8 of the mature receptors are converted to 4S versus 41% +/- 1.9 of the senescent receptors, and at 0.2 M @entity4338 79.6% +/- 3.2 of the mature receptors are converted to the 4S versus 58.2% +/- 2.1 of the senescent. @entity1329 treatment in the presence of 0.3 M @entity4338 converted about 80% of the receptors from the 4S to the 5S form, while only about half of the old receptors are affected. When @entity1329 precipitates were heated to 25 degrees C all to mature receptors were converted to the 5S species, while only two thirds of the senescent receptors were sedimented at 5S under the same conditions. Inclusion of 20 mM molybdate during preparation blocks conversion of about 15% of the senescent receptors from the 8S to the 4S form but does not affect the mature preparations. Similarly, molybdate treatment does not affect the conversion of the mature @entity53 receptors to the 5S form but increases the percentage of senescent receptors remaining in the 4S form from 30 to 45%. Such qualitative differences in receptor conversion may be related to age associated deterioration of @entity53 stimulated uterine responsiveness.

title: Impaired conversion of @entity35 uterine XXXX receptors during aging.

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol', 'Estradiol']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity1329 :: ('MESH:D000645', 'Chemical') :: ['ammonium sulfate', 'Ammonium sulfate']

answer: @entity53 :: (MESH:D004958,Chemical) :: ['estradiol']


abstract: We have examined the effects of aging on the capacity of @entity35 uterine @entity53 receptors to be transformed from 8S to 4S and 5S species. Cytosol receptors from mature (6-month-old) @entity35 or senescent (24-month-old) @entity35 have been exposed to various @entity4338 concentrations, @entity1329 precipitation and 25 degrees C heating. @entity53 receptors of both the mature and senescent age groups exist in an 8S form on linear 5-20% @entity969 gradients in the absence of @entity4338 and are converted to a 4S molecule in the presence of 0.4 M @entity4338 . At intermediate salt concentrations a greater portion of mature receptors was converted to the 4S species. At 0.15 M @entity4338 62.3% +/- 2.8 of the mature receptors are converted to 4S versus 41% +/- 1.9 of the senescent receptors, and at 0.2 M @entity4338 79.6% +/- 3.2 of the mature receptors are converted to the 4S versus 58.2% +/- 2.1 of the senescent. @entity1329 treatment in the presence of 0.3 M @entity4338 converted about 80% of the receptors from the 4S to the 5S form, while only about half of the old receptors are affected. When @entity1329 precipitates were heated to 25 degrees C all to mature receptors were converted to the 5S species, while only two thirds of the senescent receptors were sedimented at 5S under the same conditions. Inclusion of 20 mM molybdate during preparation blocks conversion of about 15% of the senescent receptors from the 8S to the 4S form but does not affect the mature preparations. Similarly, molybdate treatment does not affect the conversion of the mature @entity53 receptors to the 5S form but increases the percentage of senescent receptors remaining in the 4S form from 30 to 45%. Such qualitative differences in receptor conversion may be related to age associated deterioration of @entity53 stimulated uterine responsiveness.

title: Impaired conversion of XXXX uterine @entity53 receptors during aging.

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVE: To analyse weight change, body composition change and Body Mass Index change in @entity1 undergoing orthognathic surgery. DESIGN: A service evaluation was undertaken in orthognathic @entity1 pre-operatively and at 4 weeks post-surgery. SETTING: Queen Elizabeth Hospital Birmingham outpatient department. SUBJECTS: Thirty-one @entity1 scheduled for single- or two-jaw orthognathic surgery and rigid internal fixation. METHODS: Immediately pre-operatively and at 4 weeks post-surgery the following information was gathered: (1) @entity1 height; (2) @entity1 weight (kg); (3) @entity1 Body Mass Index; and (4) @entity1 body fat percentage. RESULTS: In the 4-week post-operative period, the average @entity353 was -4  96 kg (range: -9  6 to +3  0 kg), with a body fat reduction of -3  07% (range: -5  80% to +2  30%) and an average reduction in Body Mass Index of -1  63 (range: -3  4 to +0  8). There was no statistically significant difference in @entity353 (P=0  1562) or body fat composition change (P=0  2391) between single- or two-jaw surgery. There was no statistically significant difference in @entity353 (P=0  4858) or body fat composition change (P=0  5321) between male and female @entity1 . CONCLUSIONS: @entity353 observed was similar to that reported in studies using inter-maxillary fixation. Closer psychological and dietetic support is needed for @entity1 who have a low normal or underweight Body Mass Index. Better and more bespoke tailored Oral Nutritional Supplementation must be provided for all orthognathic surgery @entity1 to potentially reduce this significant @entity353 .

title: XXXX in orthognathic surgery: a clinical study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss', 'Weight loss']

answer: @entity353 :: (MESH:D015431,Disease) :: ['Weight loss']


abstract: Endometrium morphology has been analysed by means of light microscopy, scanning and transmission microscopy in @entity1 before and during treatment with a @entity20169 containing low dose combined pill (Cilest). Endometrium biopsies were taken after 1 (N = 3), 2 (N = 3), 3 (N = 7), 5 (N = 1) and 6 (N = 4) OC cycles. Light microscopy of the endometrium obtained during the OC-free pretreatment cycles shows a regular secretory transformed endometrium. During the first OC cycles of Cilest treatment slight @entity851 of endometrial glands was observed. Endometrium after 3 to 6 OC cycles showed an increasing delay of the growth of endometrial glands in terms of an abortive secretion. Morphometric studies revealed a retardation of the development of endometrial glands and an "arrest of secretion". The degree of proliferation varied slightly; a general delay between the date of the menstrual cycle and endometrial dating was evident. Using scanning electron microscopy the endometrium presented mostly a regular surface corresponding to the midcycle or a late proliferative phase up to the early secretory phase. Infiltrative @entity1141 or inflammatory changes as well as local proliferations could not be detected. In transmission electron microscopy with semi-thin and ultrathin slices, stroma, structure of glands and surface appeared to be normal. Furthermore, no time delay between the endometrium and the day of menstrual cycle was observed. During treatment with a @entity20169 containing low dose combined pill, only slight changes of the endometrium in terms of a @entity851 of endometrial glands were seen in the first 6 treatment cycles.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [Light and electron microscopy changes in the endometrium caused by the administration of a XXXX -containing oral contraceptive (Cilest)].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity20169 :: ('MESH:C017576', 'Chemical') :: ['norgestimate']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['growth retardation']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia']

answer: @entity20169 :: (MESH:C017576,Chemical) :: ['norgestimate']


abstract: The present investigation was undertaken to explore the @entity1066 healing properties of three dosage schedules of different strengths of topically administered @entity6478 solution in thermally produced skin @entity1066 on the side of the midline on the back of the @entity95 . Four circular thermal burns about 4.0 cm in diameter (two on either side of the midline) were made 4.0 cm apart on the pre shaved back of each anaesthetized (with @entity4490 sod., 45 mg/kg, ip) @entity95 with a heated template, applied for 30 sec. Three days later under anaesthesia, the burns were excised removing epidermis, dermis and subcutaneous tissue. The animals were randomly divided into various groups. @entity1066 on one side of the midline were treated with normal saline and served as control, whereas those on the other side were treated with @entity6478 solutions. Each @entity1066 was observed for its size, slough formation and any sign of irritation on alternate days until healing was complete. Healing of @entity1066 were significantly delay in comparison to control group with all the strength of @entity6478 (0.02%, 0.5% and 1%) in all the dosage schedule (o.d., b.i.d. and q.i.d.) in terms of days required for complete healing (except with b.i.d. dosage schedule of 0.5% _ q.i.d. dosage schedule of 1% @entity6478 solution), @entity1066 size and area under the size time curve (except with b.i.d. _q.i.d. dosage schedule of 1% @entity6478 solution). Thus, it is concluded that unlike mechanical @entity1066 topical @entity6478 delays wound repair in @entity75 .

title: Topical @entity6478 delays healing of deep thermal wounds in albino XXXX .

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['deep burn lesions']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'Ulcers', 'ulcers']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity6478 :: ('MESH:D000584', 'Chemical') :: ['amiloride']

entities_list: @entity4490 :: ('MESH:D013874', 'Chemical') :: ['thiopentone']

answer: @entity95 :: (9986,Species) :: ['rabbits']


abstract: The present investigation was undertaken to explore the @entity1066 healing properties of three dosage schedules of different strengths of topically administered @entity6478 solution in thermally produced skin @entity1066 on the side of the midline on the back of the @entity95 . Four circular thermal burns about 4.0 cm in diameter (two on either side of the midline) were made 4.0 cm apart on the pre shaved back of each anaesthetized (with @entity4490 sod., 45 mg/kg, ip) @entity95 with a heated template, applied for 30 sec. Three days later under anaesthesia, the burns were excised removing epidermis, dermis and subcutaneous tissue. The animals were randomly divided into various groups. @entity1066 on one side of the midline were treated with normal saline and served as control, whereas those on the other side were treated with @entity6478 solutions. Each @entity1066 was observed for its size, slough formation and any sign of irritation on alternate days until healing was complete. Healing of @entity1066 were significantly delay in comparison to control group with all the strength of @entity6478 (0.02%, 0.5% and 1%) in all the dosage schedule (o.d., b.i.d. and q.i.d.) in terms of days required for complete healing (except with b.i.d. dosage schedule of 0.5% _ q.i.d. dosage schedule of 1% @entity6478 solution), @entity1066 size and area under the size time curve (except with b.i.d. _q.i.d. dosage schedule of 1% @entity6478 solution). Thus, it is concluded that unlike mechanical @entity1066 topical @entity6478 delays wound repair in @entity75 .

title: Topical XXXX delays healing of deep thermal wounds in albino @entity95 .

answer: @entity6478 :: (MESH:D000584,Chemical) :: ['amiloride']


abstract: BACKGROUND AND PURPOSE: Angiotensin AT1 receptor antagonists induce @entity353 ; however, the mechanism underlying this phenomenon is unknown. The Mas receptor agonist @entity72115 is a metabolite of @entity4689 and of angiotensin II . As an agonist of Mas receptors, @entity72115 has beneficial cardiovascular and metabolic effects. EXPERIMENTAL APPROACH: We investigated the anti- @entity28 effects of transgenically overexpressed @entity72115 in @entity35 . We secondly examined whether @entity353 due to @entity9887 (8   mg  kg(-1)   d(-1) ) in diet-induced @entity28 Sprague Dawley (SD) @entity35 can be blocked when the animals were co-treated with the Mas receptor antagonist A779 (24 or 72    g  kg(-1)   d(-1) ). KEY RESULTS: In contrast to wild-type controls, transgenic @entity35 overexpressing angiotensin-(1-7) had 1.) diminished body weight when they were regularly fed with chow; 2.) were protected from developing @entity28 although they were fed with cafeteria diet (CD); 3.) showed a reduced energy intake that was mainly related to a lower CD intake; 5.) remained responsive to leptin despite chronic CD feeding; 6.) had a higher, strain-dependent energy expenditure, and 7.) were protected from developing insulin resistance despite CD feeding. @entity9887 -induced @entity353 in SD @entity35 was partially antagonized after a high, but not a low dose of A779. CONCLUSIONS AND IMPLICATIONS: Angiotensin-(1-7) regulated food intake and body weight and contributed to the @entity353 after AT1 receptor blockade. Angiotensin-(1-7)-like agonists may be drug candidates for treating @entity28 .

title: Lack of weight gain after angiotensin AT1 receptor blockade in diet-induced XXXX is partly mediated by an angiotensin-(1-7)/Mas-dependent pathway.

entities_list: @entity4689 :: ('MESH:D000803', 'Chemical') :: ['angiotensin I']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity9887 :: ('MESH:C084178', 'Chemical') :: ['Telmisartan', 'telmisartan']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: A 64-year-old @entity1 experienced an episode of disorientation in relation to time, place, and @entity1 , as well as of @entity227 and @entity73 . Physical examination showed a @entity2055 . Computerized tomography of the skull revealed a sellar mass consistent with the diagnosis of @entity977 . The @entity1 progressively lost consciousness and died. At postmortem examination, a @entity977 with arachnoid @entity3 was present. Metastatic cervical lymph nodes were also detected. Histologic aspects of the @entity5 and of lymph node @entity3 were quite similar. Immunohistochemical investigation revealed the epithelial origin of the @entity5 and failed to disclose endocrine activity. At ultrastructural examination, the cells of the @entity5 and of the @entity3 lacked specific granules. These findings support the evidence of a primary metastasizing @entity977 .

title: Endocrine inactive XXXX metastasizing to cervical lymph nodes: a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient', 'people']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual defect']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor', 'neoplasm']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired balance']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary carcinoma', 'pituitary adenoma', 'pituitary neoplasm']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity2055 :: ('MESH:D001259', 'Disease') :: ['bitemporal hemianopsia and truncal ataxia']

answer: @entity977 :: (MESH:D010911,Disease) :: ['pituitary carcinoma']


abstract: OBJECTIVE: To evaluate the efficacy of a structured transition program compared with usual care in improving routine follow-up, clinical, and psychosocial outcomes among young adults with type 1 @entity6 . RESEARCH DESIGN AND METHODS: Eighty-one young adults in their last year of pediatric care were recruited from three clinics. Intervention group (IG) @entity1 (n = 51) received a structured transition program incorporating tailored @entity6 education, case management, group education classes, and access to a newly developed young adult @entity6 clinic and transition website. Control group (CG) @entity1 (n = 30) received usual care. The primary outcome was the number of routine clinic visits. Secondary outcomes included glycemic control, @entity4053 , health-care use, and psychosocial well-being. Assessments were conducted at baseline, and 6 and 12 months. RESULTS: Limitations in CG follow-up prevented direct comparisons of adult care visits; however, at the 12-month follow-up among IG @entity1 discharged from pediatric care (n = 32), 78% had one or more adult visits. Among IG @entity1 , the total number of clinic visits did not differ between those who transitioned and those who remained in pediatric care (3.0    1.24 vs. 3.11    0.94, P = 0.74). IG compared with CG @entity1 had improved glycemic control (-0.40    1.16% vs. 0.42    1.51% [4.4    12.7 mmol/mol vs. 4.6    16.5 mmol/mol], P = 0.01), incidence of severe @entity4053 (0.0% vs. 16%, P = 0.02), and global well-being (P = 0.02) at 12 months. CONCLUSIONS: A structured transition program was successful in facilitating transition to adult care without a decrease in clinical follow-up. Compared with usual care, the transition program facilitated improvements in glycemic control, @entity4053 , and psychosocial well-being.

title: Let's Empower and Prepare (LEAP): Evaluation of a Structured Transition Program for Young Adults With Type 1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['hypoglycemia']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: BACKGROUND: Traditional resuscitation training models are inadequate to achieving and maintaining resuscitation competency. This analysis evaluates the effectiveness of a novel, performance improvement-based inpatient resuscitation programme. METHODS: This was a prospective, before-and-after study conducted in an urban, university-affiliated hospital system. All inpatient adult @entity1167 without an active Do Not Attempt Resuscitation order from July 2005 to June 2012 were included. The advanced resuscitation training (ART) programme was implemented in Spring 2007 and included a unique treatment algorithm constructed around the capabilities of our providers and resuscitation equipment, a training programme with flexible format and content including early recognition concepts, and a comprehensive approach to performance improvement feeding directly back into training. Our inpatient resuscitation registry and electronic @entity1 care record were used to quantify arrest rates and survival-to-hospital discharge before and after ART programme implementation. Multiple logistic regression analysis was used to adjust for age, gender, location of arrest, initial rhythm, and time of day. RESULTS: A total of 556 @entity1167 were included (182 pre- and 374 post-ART). Arrest incidence decreased from 2.7 to 1.2 per 1000 @entity1 discharges in non-ICU inpatient units, with no change in ICU arrest rate. An increase in survival-to-hospital discharge from 21 to 45% (p<0.01) was observed following ART programme implementation. Adjusted odds ratios for survival-to-discharge (OR 2.2, 95% CI 1.4-3.4) and good neurological outcomes (OR 3.0, 95% CI 1.7-5.3) reflected similar improvements. Arrest-related @entity204 decreased from 2.1 to 0.5 @entity204 per 1000 @entity1 discharges in non-ICU areas and from 1.5 to 1.3 @entity204 per 1000 @entity1 discharges in ICU areas, and overall hospital mortality decreased from 2.2% to 1.8%. CONCLUSIONS: Implementation of a novel, performance improvement-based inpatient resuscitation programme was associated with a decrease in the incidence of @entity1167 and improved clinical outcomes.

title: A performance improvement-based resuscitation programme reduces arrest incidence and increases survival from in-hospital XXXX .

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest victims', 'cardiac arrest']

answer: @entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']


abstract: INTRODUCTION: @entity521 ( @entity521 ) is the most frequent indication for extracranial pediatric radiotherapy. As long-term survival of high-risk localized @entity521 has greatly improved, we reviewed treatment-related late @entity137 in pediatric @entity1 who received postoperative radiotherapy (RT) for localized @entity521 within two French prospective clinical trials: NB90 and NB94. @entity1 AND METHODS: From 1990-2000, 610 @entity1 were enrolled. Among these, 35 were treated with induction chemotherapy, surgery, and RT. The recommended RT dose was 24  Gy at  <=   2  years, 34  Gy at >   2  years,    a 5  Gy boost in both age groups. RESULTS: The 22 @entity1 still alive after 5  years were analyzed. The median follow-up time was 14  years (range 5-21  years). Late effects after therapy occurred in 73   % of @entity1 (16/22), within the RT field for 50   % (11/22). The most frequent in-field effects were @entity85 (n   =   7) that occurred only with doses >   31  Gy/1.5  Gy fraction (p   =   0.037). Other effects were endocrine in 3  @entity1 and second @entity5 in 2  @entity1 . Four @entity1 presented with multiple in-field late effects only with doses >   31  Gy. CONCLUSION: After a median follow-up of 14  years, late effects with multimodality treatment were frequent. The most frequent effects were @entity85 and the threshold for their occurrence was 31  Gy.

title: Long-term side effects of radiotherapy for XXXX : Results from clinical trials NB90 and NB94.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['NB', 'Neuroblastoma']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal abnormalities']

answer: @entity521 :: (MESH:D009447,Disease) :: ['pediatric localized neuroblastoma']


abstract: PURPOSE: The purpose of this study was to establish a simple, xeno-feeder-free method for cultivating @entity1 corneal epithelial cells. METHODS: Limbal tissue explants from a cadaver were cultured in Iscove's modified Dulbecco's medium and low- @entity460 Panserin 801 medium in a 1:1 ratio. The outgrowing cells were characterized by flow cytometry, immunohistochemistry and real-time PCR (rtPCR). Limbal epithelial cells were expanded in a xeno-feeder-free, low- @entity460 medium and airlifted for 2 weeks each. RESULTS: Migration of fibroblast-like stromal cells initially occurred from the limbal explants, and then epithelial cells migrated and grew on the stromal cells as an autofeeder layer. After airlifting, the cultured epithelium consisted of two to three layers. The cultured cells expressed stem cell-associated markers ( @entity10430 and   Np63), differentiation markers ( @entity16914 and @entity16915 ) and extracellular matrix-associated markers (lumican and decorin). rtPCR showed increased expression of markers for epithelial progenitor cells compared to fresh limbal tissue. Side population cells comprised 0.43    0.04% of the cells (n = 5) in the primary culture. Flow cytometry showed that 49.12, 40.44 and 44.55% of the cells from the explants expressed @entity5962 ,   Np63 and @entity10430 , respectively. CONCLUSION: This explant culture system using stromal cells as an autofeeder layer was useful in expanding @entity1 corneal epithelial cells. This system may offer clinical insight for the expansion of limbal progenitor cells for the reconstruction of the ocular surface.

title: Ex vivo XXXX corneal epithelial cell expansion from a xeno-feeder-free system.

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: The aim of the study is to evaluate gender-related socio-demographic and clinical differences in a large sample of inpatients with @entity161 spectrum disorder. A sample of 353 acute @entity1 , consecutively hospitalized between January 2007 and December 2008 in the Psychiatric Emergency Service of the San Giovanni Battista Hospital, was recruited. Psychiatric assessment included the Clinical Global Impression Scale-Severity (CGI-S), the Brief Psychiatric Rating Scale (BPRS) and the Global Assessment of Functioning (GAF). Differences between the groups were tested using chi-square test and ANOVA. Data were analyzed using a three-way MANOVA with the six BPRS scales with repeated measures for admission/discharge and BPRS total score baseline and independent groups for @entity1 and @entity1 . A two-way ANOVA for repeated measures was performed for CGI-S and GAF. @entity1 were younger, more likely to be never married, more often substance abusers. Male @entity1 showed both lower @entity308 and anergia symptom scores and higher activation symptom scores than female @entity1 . Brief hospitalization was shown to be highly effective in both groups. Females showed a significantly better improvement in anergia and activation than males. The present evidence suggests that management of acute @entity716 should target specific gender differences which should influence therapeutic approach in all its modalities.

title: Gender differences in 353 inpatients with acute XXXX : The experience of one Psychiatric Emergency Service of Turin.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Men', 'men']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['anxious-depressive']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

answer: @entity716 :: (MESH:D011605,Disease) :: ['psychosis']


abstract: @entity71 following @entity1566 ( @entity1566 ) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after @entity1566 ( @entity1566 ). @entity35 bone marrow-derived mesenchymal stem cells (MSCs), genetically engineered to overexpress @entity10865 , receptor of @entity10862 ( @entity10862 ), were pre-differentiated into cells carrying neuronal features via co-culture with @entity10862 overproducing Schwann cells in 3-dimensional @entity19372 ( @entity19372 ) scaffold for 14 days in  vitro. Intra- @entity19372 formation of MSC assemblies emulating neural network (MSC- @entity19372 ) were verified morphologically via electron microscopy (EM) and functionally by whole-cell patch clamp recording of spontaneous post-synaptic currents. The differentiated MSCs still partially maintained prototypic property with the expression of some mesodermal cytokines. MSC- @entity19372 or @entity19372 was then grafted acutely into a 2  mm-wide transection gap in the T9-T10 spinal cord segments of adult @entity35 . Eight weeks later, hindlimb function of the MSC- @entity19372 -treated @entity1566 @entity35 was significantly improved relative to controls receiving the @entity19372 or lesion only as indicated by BBB score. The MSC- @entity19372 transplantation also significantly recovered cortical motor evoked potential (CMEP). Histologically, MSC-derived neuron-like cells maintained their synapse-like structures in  vivo; they additionally formed similar connections with host neurites (i.e., mostly serotonergic fibers plus a few corticospinal axons; validated by double-labeled immuno-EM). Moreover, motor cortex electrical stimulation triggered @entity5019 expression in the grafted and lumbar spinal cord cells of the treated @entity35 only. Our data suggest that MSC-derived neuron-like cells resulting from @entity10862 - @entity10865 -induced differentiation can partially integrate into transected spinal cord and this strategy should be further investigated for reconstructing disrupted neural circuits.

title: Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after @entity35 XXXX .

entities_list: @entity19372 :: ('MESH:D007691', 'Disease') :: ['gelatin sponge', 'GS']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['Functional deficits']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury', 'SCI', 'spinal cord transection', 'SCT']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord transection']


abstract: @entity71 following @entity1566 ( @entity1566 ) primarily attribute to loss of neural connectivity. We therefore tested if novel tissue engineering approaches could enable neural network repair that facilitates functional recovery after @entity1566 ( @entity1566 ). @entity35 bone marrow-derived mesenchymal stem cells (MSCs), genetically engineered to overexpress @entity10865 , receptor of @entity10862 ( @entity10862 ), were pre-differentiated into cells carrying neuronal features via co-culture with @entity10862 overproducing Schwann cells in 3-dimensional @entity19372 ( @entity19372 ) scaffold for 14 days in  vitro. Intra- @entity19372 formation of MSC assemblies emulating neural network (MSC- @entity19372 ) were verified morphologically via electron microscopy (EM) and functionally by whole-cell patch clamp recording of spontaneous post-synaptic currents. The differentiated MSCs still partially maintained prototypic property with the expression of some mesodermal cytokines. MSC- @entity19372 or @entity19372 was then grafted acutely into a 2  mm-wide transection gap in the T9-T10 spinal cord segments of adult @entity35 . Eight weeks later, hindlimb function of the MSC- @entity19372 -treated @entity1566 @entity35 was significantly improved relative to controls receiving the @entity19372 or lesion only as indicated by BBB score. The MSC- @entity19372 transplantation also significantly recovered cortical motor evoked potential (CMEP). Histologically, MSC-derived neuron-like cells maintained their synapse-like structures in  vivo; they additionally formed similar connections with host neurites (i.e., mostly serotonergic fibers plus a few corticospinal axons; validated by double-labeled immuno-EM). Moreover, motor cortex electrical stimulation triggered @entity5019 expression in the grafted and lumbar spinal cord cells of the treated @entity35 only. Our data suggest that MSC-derived neuron-like cells resulting from @entity10862 - @entity10865 -induced differentiation can partially integrate into transected spinal cord and this strategy should be further investigated for reconstructing disrupted neural circuits.

title: Integration of donor mesenchymal stem cell-derived neuron-like cells into host neural network after XXXX @entity1566 .

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: UNASSIGNED: We evaluate the clinical effects and radiological findings of the Wallis interspinous device (Zimmer, Warsaw, IN, USA) for the treatment of @entity179 after a minimum 5year follow-up period. A total of 26 adult @entity1 underwent a primary discectomy followed by fixation of the segment with the Wallis interspinous device between December 2007 and August 2008. Twelve @entity1 and 14 @entity1 with an age range of 43 to 56years (average: 47.6) were included. The visual analogue scale (VAS) for @entity1643 , @entity717 Index (ODI), foraminal height (FH), anterior disc height (aDH) and posterior disc height (pDH), range of motion (ROM) and Pfirrmann grades were obtained and compared before and after surgery. The VAS and ODI significantly decreased postoperatively (p<0.05). The postoperative FH and pDH values increased significantly compared with the preoperative levels (p<0.01) and the increase in the FH and pDH values remained statistically significant during the follow-up period. There were no statistically significant changes in the aDH values before and after surgery (p>0.05). Also, there were no statistically significant changes in the ROM and Pfirrmann grade at the instrumented level and at the cephalad-adjacent segment (p>0.05). In our study, no @entity1 underwent further surgery because of a re-prolapse or progression of index level degeneration or @entity1347 . The Wallis interspinous device was a useful alternative for treating @entity179 and it offered a significant minimum 5year symptom control.

title: Minimum 5year follow-up of XXXX treated with discectomy and the Wallis interspinous device.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back and leg pain']

entities_list: @entity1347 :: ('MESH:C537775', 'Disease') :: ['adjacent segment disease']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['multi-segmental lumbar degenerative disease']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability']

answer: @entity179 :: (MESH:D019636,Disease) :: ['multi-segmental lumbar degenerative disease']


abstract: BACKGROUND: We hypothesized @entity1592 ( @entity1592 ) demonstrate higher rates of @entity146 and higher dominance ranks than control (CTR) offspring with normal weight at term; if @entity146 is advantageous during resource scarcity, developmental programming may lead to an association between @entity146 and @entity1592 . METHODS: We studied 22 group-housed @entity6599 (ages 3-5  years). CTR (male n  =  8, female n  =  5) mothers ate ad  libitum. @entity1592 (male n  =  4, female n  =  5) mothers were fed 70% feed eaten by CTR mothers during pregnancy and lactation. RESULTS: @entity1592 showed higher rates of @entity146 (P  <  0.02). Dominance ranks and physical @entity146 rates did not differ between groups. CONCLUSIONS: High rates of @entity851 might reflect developmental programming of behavioral phenotypes enhancing @entity410 . Friendly displays may reflect reconciliation. Potential mechanisms include neurodevelopment and learning. Exploration of @entity1592 as a risk factor for behavioral patterns is important for developing diagnostic and therapeutic strategies.

title: Increased @entity146 and affiliative display behavior in intrauterine growth restricted XXXX .

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['IUGR aggressive display']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggression', 'aggressive displays (P  <  0.01) and friendly displays', 'aggressive behavior']

entities_list: @entity1592 :: ('MESH:D005317', 'Disease') :: ['IUGR', 'intrauterine growth restricted offspring']

answer: @entity6599 :: (9557,Species) :: ['baboons']


abstract: BACKGROUND: We hypothesized @entity1592 ( @entity1592 ) demonstrate higher rates of @entity146 and higher dominance ranks than control (CTR) offspring with normal weight at term; if @entity146 is advantageous during resource scarcity, developmental programming may lead to an association between @entity146 and @entity1592 . METHODS: We studied 22 group-housed @entity6599 (ages 3-5  years). CTR (male n  =  8, female n  =  5) mothers ate ad  libitum. @entity1592 (male n  =  4, female n  =  5) mothers were fed 70% feed eaten by CTR mothers during pregnancy and lactation. RESULTS: @entity1592 showed higher rates of @entity146 (P  <  0.02). Dominance ranks and physical @entity146 rates did not differ between groups. CONCLUSIONS: High rates of @entity851 might reflect developmental programming of behavioral phenotypes enhancing @entity410 . Friendly displays may reflect reconciliation. Potential mechanisms include neurodevelopment and learning. Exploration of @entity1592 as a risk factor for behavioral patterns is important for developing diagnostic and therapeutic strategies.

title: Increased XXXX and affiliative display behavior in intrauterine growth restricted @entity6599 .

answer: @entity146 :: (MESH:D001523,Disease) :: ['aggressive']


abstract: UNASSIGNED: The nonphysiological mechanical shear stress in blood-contacting medical devices is one major factor to device-induced @entity16 . Animal blood is often used to test device-induced @entity16 potential of these devices due to its easy accessibility and low cost. However, the differences in shear-induced @entity16 between animals and @entity1 have not been well characterized. The purpose of this study was to investigate shear-induced @entity2142 of @entity1 and three commonly used preclinical evaluation animal species (ovine, porcine, and @entity291 ) under shear conditions encountered in blood-contacting medical devices. Shear-induced @entity2142 experiments were conducted using two single-pass blood-shearing devices. Driven by an externally pressurized reservoir, blood single-passes through a small annular gap in the shearing devices where the blood was exposed to a uniform high shear stress. Shear-induced @entity2142 at different conditions of exposure time (0.04 to 1.5   s) and shear stress (25 to 320   Pa) was quantified for ovine, porcine, @entity291 , and @entity1 blood, respectively. Within these ranges of shear stress and exposure time, shear-induced @entity2142 was less than 2% for the four species. The results showed that the ovine blood was more susceptible to shear-induced injury than the @entity291 , porcine, and @entity1 blood. The response of the porcine and @entity291 blood to shear was similar to the @entity1 blood. The dependence of @entity2142 on shear stress level and exposure time was found to fit well the power law functional form for the four species. The coefficients of the power law models for the ovine, porcine, @entity291 , and @entity1 blood were derived.

title: Shear-Induced XXXX : Species Differences.

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['blood damage']

entities_list: @entity2142 :: ('MESH:D006461', 'Disease') :: ['hemolysis']

answer: @entity2142 :: (MESH:D006461,Disease) :: ['Hemolysis']


abstract: BACKGROUND: Methodological guidelines for intervention reporting emphasise describing intervention content in detail. Despite this, systematic reviews of quality improvement (QI) implementation interventions continue to be limited by a lack of clarity and detail regarding the intervention content being evaluated. We aimed to apply the recently developed Behaviour Change Techniques Taxonomy version 1 (BCTTv1) to trials of implementation interventions for managing @entity6 to assess the capacity and utility of this taxonomy for characterising active ingredients. METHODS: Three psychologists independently coded a random sample of 23 trials of healthcare system, provider- and/or @entity1 -focused implementation interventions from a systematic review that included 142 such studies. Intervention content was coded using the BCTTv1, which describes 93 behaviour change techniques (BCTs) grouped within 16 categories. We supplemented the generic coding instructions within the BCTTv1 with decision rules and examples from this literature. RESULTS: Less than a quarter of possible BCTs within the BCTTv1 were identified. For implementation interventions targeting providers, the most commonly identified BCTs included the following: adding objects to the environment, prompts/cues, instruction on how to perform the behaviour, credible source, goal setting (outcome), feedback on outcome of behaviour, and social support (practical). For implementation interventions also targeting @entity1 , the most commonly identified BCTs included the following: prompts/cues, instruction on how to perform the behaviour, information about health consequences, restructuring the social environment, adding objects to the environment, social support (practical), and goal setting (behaviour). The BCTTv1 mapped well onto implementation interventions directly targeting clinicians and @entity1 and could also be used to examine the impact of system-level interventions on clinician and @entity1 behaviour. CONCLUSIONS: The BCTTv1 can be used to characterise the active ingredients in trials of implementation interventions and provides specificity of content beyond what is given by broader intervention labels. Identification of BCTs may provide a more helpful means of accumulating knowledge on the content used in trials of implementation interventions, which may help to better inform replication efforts. In addition, prospective use of a behaviour change techniques taxonomy for developing and reporting intervention content would further aid in building a cumulative science of effective implementation interventions.

title: Using a behaviour change techniques taxonomy to identify active ingredients within trials of implementation interventions for XXXX care.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: UNASSIGNED: BACKGROUND @entity3291 are the most common primary @entity4617 and are closely associated with @entity887 . @entity299 typically arise from the interatrial septum at the border of the fossa ovalis in the left atrium. Any other location is considered atypical. @entity887 , one of the complications of @entity3291 , is associated with high morbidity and mortality. The aim of this study was to investigate the risk factors for @entity887 in @entity1 with @entity299 . MATERIAL AND METHODS In this retrospective study, a cohort of 162 @entity1 with @entity299 was surgically treated between January 1998 and June 2014 at 3 cardiac centers in China. Preoperative data, including platelet count, sex, age, and the @entity5 (size, location, surface, and attachment), were compared between embolic and non-embolic groups of @entity1 . RESULTS No significant differences in vascular risk factors were seen between the 2 groups. However, the percentage of higher platelet count (>300*10^9/L) and mean platelet volume in the embolic group were significantly higher than in the non-embolic group (P=0.0356, and 0.0113, respectively). Irregular surface and atypical location of the @entity3291 were also independently associated with increased risk of @entity887 . CONCLUSIONS @entity5 location, macroscopic appearance, mean platelet volume, and high platelet count are strong risk factors for @entity887 in @entity1 with @entity299 .

title: Risk Factors for XXXX : A Retrospective Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity3291 :: ('MESH:D009232', 'Disease') :: ['Myxomas', 'myxomas', 'myxoma']

entities_list: @entity4617 :: ('MESH:D006338', 'Disease') :: ['heart tumors']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolic events', 'embolic complications', 'embolism', 'Embolism']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac myxoma', 'cardiac myxomas', 'Cardiac myxomas']

answer: @entity299 :: (MESH:D006331,Disease) :: ['Embolism in Cardiac Myxoma']


abstract: OBJECTIVE: @entity903 titration may be difficult in older individuals as they are more sensitive to side effects. The current study extends to 6   months our previously published report in which @entity903 was started at 2.5   mg/day and slowly increased by 2.5   mg on alternate days (slow titration) or rapidly titrated to target dose from 10   mg/day (standard titration) in a naturalistic setting. METHODS: Here, the follow-up period was extended to 26   weeks. We performed an intent-to-treat analysis of 47 subjects from the original sample (major @entity308 and/or @entity148 ( @entity148 ); >60   years of age). Missing evaluations were replaced by last observations carried forward. @entity148 was included as a stratification factor. RESULTS: @entity1 in whom @entity903 was slowly up-titrated were more likely to remit (84.0% vs 54.5%; p   =   0.028) and had lower core @entity308 (p   =   0.0015) and @entity148 (p   =   0.006) after 26   weeks. Dropout rate was 20% in the slow titration group compared with 77.3% in the standard titration arm (p   <   0.001). @entity1 with @entity148 accounted for all significant associations. No substantial differences were reported between slow and standard titration groups in the subsample without @entity148 . CONCLUSIONS: Despite some limitations, these findings suggest that @entity903 treatment should be started at lower doses in older @entity308 @entity1 and slowly up-titrated. This strategy would allow to increase antidepressant response and the likelihood of completing treatment cycle in @entity1 with high anxiety levels and @entity148 comorbidity. Copyright    2015 John Wiley _ Sons, Ltd.

title: Persistent benefits of slow titration of XXXX in a six-month follow-up.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder', 'depressed', 'depression']

entities_list: @entity903 :: ('MESH:D017374', 'Chemical') :: ['Paroxetine', 'paroxetine']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['GAD', 'psychic anxiety levels', 'generalized anxiety disorder']

answer: @entity903 :: (MESH:D017374,Chemical) :: ['paroxetine']


abstract: Intraductal @entity4929 (IPMNs) of the pancreas are classified into the following four histopathologic subtypes: gastric, intestinal, pancreatobiliary, and oncocytic. However, the clinicopathologic characteristics of IPMN subtypes have not been fully clarified. Recently, a subgroup classification of @entity1377 ( @entity1377 ) was suggested in contrast to overt @entity189 from IPMCs (IC-IPMCs). The purpose of this study was to determine whether or not the pathologic subtype classification can predict prognosis and to validate the usefulness of the newly proposed diagnostic criteria of @entity1377 . We reviewed the clinicopathologic characteristics of 142 surgically resected cases of IPMNs. There were 54, 56, 30, and two cases of the gastric, intestinal, pancreatobiliary, and oncocytic types of IPMNs, respectively. The intestinal and pancreatobiliary types were more likely to have a main duct type. All @entity356 were @entity652 or @entity19354 , whereas greater than one half of the @entity4056 in situ or invasive @entity189 . A significant difference in recurrence and @entity204 rate was noted for @entity189 between the intestinal and pancreatobiliary types. The majority of @entity1377 were the intestinal type, whereas the majority of IC-IPMCs were the pancreatobiliary type. The IC-IPMC group showed a decreased recurrence-free and overall survival with statistically significance (p < 0.001 and p = 0.001, respectively). Our results suggest that the pathologic subtype classification and the newly proposed diagnostic criteria for minimal invasion may also be useful to predict prognosis of IPMNs of the pancreas.

title: Prognostic relevance of pathologic subtypes and minimal invasion in XXXX of the pancreas.

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['minimally invasive intraductal papillary mucinous carcinomas', 'MI-IPMCs']

entities_list: @entity4929 :: ('MESH:C565310', 'Disease') :: ['papillary mucinous neoplasms']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas', 'invasive carcinoma']

entities_list: @entity4056 :: ('MESH:D007414', 'Disease') :: ['intestinal and pancreatobiliary types were carcinomas']

entities_list: @entity19354 :: ('MESH:C565640', 'Disease') :: ['moderate dysplasia']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adenomas']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric type tumors']

answer: @entity4929 :: (MESH:C565310,Disease) :: ['intraductal papillary mucinous neoplasms']


abstract: BACKGROUND: Nonoperative management (NOM) of solid organ injury after @entity130 is now standard. Recently, angioembolization (AE) has been used to extend NOM. Few data exist on evaluating NOM of blunt @entity8 (BRIs). We sought to determine the overall efficacy of NOM as well as the outcome of AE in @entity1 with BRI. METHODS: The trauma registry was used to identify all @entity1 with BRI between January 2002 and December 2008. Medical records were reviewed for demographics, grade of injury, use of angiographic intervention, and outcome. RESULTS: A total of 434 @entity1 with BRI were identified, 416 of whom had planned NOM; 337 (81%) @entity1 were successfully managed without further intervention for their BRI. In all, 79 (19%) @entity1 underwent angiography; 22 (27.8%) of these @entity1 underwent AE, and 6 (27.2%) failed 1.2    0.8 days after AE. @entity1 who failed AE had a significantly higher blood transfusion requirement during the first 24 h of admission (p = 0.01). Seven @entity1 not embolized failed 1.9    1.9 days after angiography. Thus, of the 79 @entity1 having angiography, 13 (16.5%) failed and required laparotomy to treat their BRIs. Overall failure rate of NOM was 3.1% (13/416). @entity1 who failed angiography, with or without AE, required more blood during the first 24 h after admission (p = 0.03). CONCLUSIONS: NOM of BRI is safe and effective, with an overall failure rate of 3.1%. However, angiography with or without AE has substantial failure rates. @entity1 with higher-grade injuries and active vascular extravasation on admission computed tomography scan also fail NOM regardless of therapy. The blood transfusion requirement during the first 24 h may indicate who will require operative intervention following angiography. Close observation and/or early laparotomy are wise for these high-risk @entity1 .

title: Angiointervention: high rates of failure following blunt XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal injuries']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['blunt trauma']

answer: @entity8 :: (MESH:D007674,Disease) :: ['renal injuries']


abstract: OBJECTIVES: @entity12457 remain the most important cause of morbidity and mortality in liver transplant recipients. Fast and accurate causative diagnoses are essential for a good outcome. Bronchoscopy with bronchoalveolar lavage frequently is performed to diagnose @entity358 in immunocompromised @entity1 . The aim of this study was to evaluate the diagnostic use of bronchoalveolar lavage in liver transplant recipients with @entity358 . MATERIALS AND METHODS: We retrospectively analyzed the data of 408 @entity1 who underwent liver transplant from January 1990 to December 2012. @entity1 who underwent bronchoalveolar lavage after transplant were included in this study. RESULTS: There were 18 of 408 liver transplant recipients (4.41%) who underwent bronchoalveolar lavage after transplant. The mean age was 49.5    18 years. In 5 @entity1 (27.8%), fungal microorganisms were observed in the cytology of bronchoalveolar lavage specimens, including @entity54 in 3 @entity1 and @entity5132 in 2 @entity1 . @entity204 occurred in 4 of 5 @entity1 (80%) with @entity364 . No association was observed between the presence of @entity364 and clinical and radiographic findings of the @entity1 . CONCLUSIONS: Bronchoscopy with bronchoalveolar lavage is a useful, noninvasive diagnostic tool for the rapid diagnosis of @entity281 in solid-organ transplant recipients.

title: Role of bronchoalveolar lavage in diagnosis of XXXX in liver transplant recipients.

entities_list: @entity12457 :: ('MESH:D008172', 'Disease') :: ['Pulmonary fungal infections']

entities_list: @entity5132 :: ('5476', 'Species') :: ['Candida albicans']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections', 'fungal infection']

entities_list: @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary infections']

answer: @entity364 :: (MESH:D009181,Disease) :: ['fungal infections']


abstract: UNASSIGNED: This study investigates symptom relief in @entity1 whose @entity1649 ( @entity1649 ) were completely relieved following microvascular decompression (MVD). @entity1 with @entity1649 who were operated on from January 2007 to May 2011, at our department, were studied. The medical records and operation videos of each @entity1 were reviewed. Follow-up was performed via telephone communication. A total of 410 @entity1 with @entity1649 were divided into two groups: Group A (277 cases): @entity1649 caused by @entity2850 , and Group B (133 cases): @entity1649 caused by vertebral artery compression. Magnetic resonance imaging (MRI) was performed on all the @entity1 to rule out those with secondary @entity1649 . @entity1 who had undergone previous MVD were also excluded at that time. In all, 462 @entity1 underwent MVD for @entity1649 in our center during the study period. Follow-up was available for 410 @entity1 . In the @entity2850 cohort, 72 (72/277, 26.0  %) @entity1649 @entity1 achieved relief with @entity245 . While in the vertebral artery compression cohort, 52 (52/133, 39.1  %) @entity1649 @entity1 experienced relief with @entity245 . There was significant difference between these two cohorts (P  <  0.05). 93.75% of @entity245 @entity1 were cured and experienced @entity2473 relief within 6  months. Surgeons should be aware that delayed symptom relief after MVD for @entity1649 is more common than has been reported, and time course of symptom relief is various as well as unpredictable; however, most @entity1649 @entity1 are cured, and experience @entity2473 relief within 6  months.

title: Clinical analysis of hemifacial XXXX @entity1 with delay symptom relief after microvascular decompression of distinct offending vessels.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['delayed healing']

entities_list: @entity2850 :: ('MESH:D009408', 'Disease') :: ['small vascular compression']

entities_list: @entity1649 :: ('MESH:D019569', 'Disease') :: ['hemifacial spasms', 'HFS']

answer: @entity2473 :: (MESH:D013035,Disease) :: ['spasm']


abstract: UNASSIGNED: This study investigates symptom relief in @entity1 whose @entity1649 ( @entity1649 ) were completely relieved following microvascular decompression (MVD). @entity1 with @entity1649 who were operated on from January 2007 to May 2011, at our department, were studied. The medical records and operation videos of each @entity1 were reviewed. Follow-up was performed via telephone communication. A total of 410 @entity1 with @entity1649 were divided into two groups: Group A (277 cases): @entity1649 caused by @entity2850 , and Group B (133 cases): @entity1649 caused by vertebral artery compression. Magnetic resonance imaging (MRI) was performed on all the @entity1 to rule out those with secondary @entity1649 . @entity1 who had undergone previous MVD were also excluded at that time. In all, 462 @entity1 underwent MVD for @entity1649 in our center during the study period. Follow-up was available for 410 @entity1 . In the @entity2850 cohort, 72 (72/277, 26.0  %) @entity1649 @entity1 achieved relief with @entity245 . While in the vertebral artery compression cohort, 52 (52/133, 39.1  %) @entity1649 @entity1 experienced relief with @entity245 . There was significant difference between these two cohorts (P  <  0.05). 93.75% of @entity245 @entity1 were cured and experienced @entity2473 relief within 6  months. Surgeons should be aware that delayed symptom relief after MVD for @entity1649 is more common than has been reported, and time course of symptom relief is various as well as unpredictable; however, most @entity1649 @entity1 are cured, and experience @entity2473 relief within 6  months.

title: Clinical analysis of hemifacial @entity2473 XXXX with delay symptom relief after microvascular decompression of distinct offending vessels.

answer: @entity1 :: (9606,Species) :: ['patients']