abstract: UNASSIGNED: @entity1352 is a rare @entity5 of mesenchymal multipotent cells. We hereby present a case of @entity1352 of the upper left thigh. A 19-year-old @entity1 was referred to our clinic by another hospital in Bucharest, Romania, for a soft tissue mass in the left upper thigh. Local examination of the left thigh revealed a 15  13 cm, ovoid, painful upon touch, soft tissue mass occupying the proximal-medial aspect of the thigh. Bilateral inguinal nodes' enlargement was noticed. Upon suspecting regional node involvement, the surgical team decided to perform left limb amputation due to @entity5 size and the proximity to major arterial and nervous trunks as well as the femoral shaft, making curative surgery and 'free of disease' resection margins improbable. The @entity1 refused the operation. The surgical team (plastic surgeon, orthopedic surgeon) decided to attempt limb-sparing surgery. After @entity5 resection, free-of-disease surgical margins were achieved. The pathological examination as well as the immunohistochemistry (IHC) diagnosed a large biphasic @entity1352 warranting oncologic treatment. The association between @entity5 growth and pregnancy poses important therapeutic problems, such as the use of preoperative chemotherapy, potential pregnancy termination, limb amputation versus limb salvage intervention and types of protocols of chemotherapy or radiotherapy indicated.

title: Biphasic XXXX in a 19-year-old pregnant @entity1 : a case report.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor']

entities_list: @entity1352 :: ('MESH:D013584', 'Disease') :: ['synovial sarcoma', 'Synovial sarcoma']

answer: @entity1352 :: (MESH:D013584,Disease) :: ['synovial sarcoma']


abstract: UNASSIGNED: @entity1352 is a rare @entity5 of mesenchymal multipotent cells. We hereby present a case of @entity1352 of the upper left thigh. A 19-year-old @entity1 was referred to our clinic by another hospital in Bucharest, Romania, for a soft tissue mass in the left upper thigh. Local examination of the left thigh revealed a 15  13 cm, ovoid, painful upon touch, soft tissue mass occupying the proximal-medial aspect of the thigh. Bilateral inguinal nodes' enlargement was noticed. Upon suspecting regional node involvement, the surgical team decided to perform left limb amputation due to @entity5 size and the proximity to major arterial and nervous trunks as well as the femoral shaft, making curative surgery and 'free of disease' resection margins improbable. The @entity1 refused the operation. The surgical team (plastic surgeon, orthopedic surgeon) decided to attempt limb-sparing surgery. After @entity5 resection, free-of-disease surgical margins were achieved. The pathological examination as well as the immunohistochemistry (IHC) diagnosed a large biphasic @entity1352 warranting oncologic treatment. The association between @entity5 growth and pregnancy poses important therapeutic problems, such as the use of preoperative chemotherapy, potential pregnancy termination, limb amputation versus limb salvage intervention and types of protocols of chemotherapy or radiotherapy indicated.

title: Biphasic @entity1352 in a 19-year-old pregnant XXXX : a case report.

answer: @entity1 :: (9606,Species) :: ['woman']


abstract: PURPOSE/OBJECTIVE: Two complementary frameworks, the common sense model, and @entity73 , were used. The first purpose of this study was to compare 2 groups varying in their illness perceptions (strong vs. weak) on baseline differences in theory-based exercise cognitions (self-regulatory efficacy and outcome expectations), and health-related quality of life (HRQL). The second purpose was to examine illness perception group differences in cardiac rehabilitation exercise participation following 3 months of exercise therapy. Research Method/Design: Newly enrolled cardiac rehabilitation @entity1 (N = 49) completed baseline measures of illness perceptions, self-regulatory efficacy, outcome expectations, and HRQL. Cardiac rehabilitation exercise minutes were measured at baseline (after 2 weeks of participation) and following 3 months of cardiac rehabilitation. RESULTS: Individuals were successfully classified into strong and weak illness perception groups using cluster analysis. Analyses of variance indicated significant group differences on negative outcome expectations (p < .05), where the strong illness perception group reported greater negative outcome expectations. The strong illness perception group also reported significantly lower physical and mental HRQL as compared to their weak illness perception counterparts (p < .01). Parallel differences in cardiac rehabilitation exercise participation at 3 months were also observed (p < .05). CONCLUSIONS/IMPLICATIONS: This study was a first attempt to utilize the common sense model and @entity73 to examine individuals engaged in rehabilitation to reduce cardiac risk. The findings suggest that complementary use of these 2 frameworks to study individual illness perception differences relative to @entity458 and adherence to exercise therapy may aid understanding of correlates of exercise adherence among cardiac rehabilitation @entity1 . (PsycINFO Database Record

title: Illness perceptions and adherence to exercise therapy in cardiac rehabilitation XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['social-cognitive theory']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological beliefs']

answer: @entity1 :: (9606,Species) :: ['participants']


abstract: UNASSIGNED: ADARs ( @entity859 deaminases that act on RNA) "edit" RNA by converting @entity41931 to @entity39859 within double-stranded regions. The primary targets of ADARs are long duplexes present within noncoding regions of mRNAs, such as introns and 3' untranslated regions (UTRs). Because @entity859 and @entity14572 have different base-pairing properties, editing within these regions can alter splicing and recognition by small RNAs. However, despite numerous studies identifying multiple editing sites in these genomic regions, little is known about the extent to which editing sites co-occur on individual transcripts or the functional output of these combinatorial editing events. To begin to address these questions, we performed an ultra-deep sequencing analysis of 4 @entity2199 3' UTRs that are known ADAR targets. Synchronous editing events were determined for the long duplexes in vivo. Furthermore, the validity of each editing event was confirmed by sequencing the same regions of mRNA from worms that lack A-to-I editing. This analysis identified a large number of editing sites that can occur within each 3' UTR, but interestingly, each individual transcript contained only a small fraction of these A-to-I editing events. In addition, editing patterns were not random, indicating that an editing event can affect the efficiency of editing at subsequent @entity41931 . Furthermore, we identified specific sites that can be both positively and negatively correlated with additional sites leading to mutually exclusive editing patterns. These results suggest that editing in noncoding regions is selective and hyper-editing of cellular RNAs is rare.

title: Noncoding regions of @entity2199 mRNA undergo selective XXXX to @entity14572 deamination and contain a small number of editing sites per transcript.

entities_list: @entity2199 :: ('6239', 'Species') :: ['Caenorhabditis elegans']

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['Adenosine', 'adenosine']

entities_list: @entity39859 :: ('CHEBI:24844', 'Chemical') :: ['inosines']

entities_list: @entity41931 :: ('CHEBI:22260', 'Chemical') :: ['adenosines']

answer: @entity859 :: (MESH:D000241,Chemical) :: ['adenosine']


abstract: UNASSIGNED: ADARs ( @entity859 deaminases that act on RNA) "edit" RNA by converting @entity41931 to @entity39859 within double-stranded regions. The primary targets of ADARs are long duplexes present within noncoding regions of mRNAs, such as introns and 3' untranslated regions (UTRs). Because @entity859 and @entity14572 have different base-pairing properties, editing within these regions can alter splicing and recognition by small RNAs. However, despite numerous studies identifying multiple editing sites in these genomic regions, little is known about the extent to which editing sites co-occur on individual transcripts or the functional output of these combinatorial editing events. To begin to address these questions, we performed an ultra-deep sequencing analysis of 4 @entity2199 3' UTRs that are known ADAR targets. Synchronous editing events were determined for the long duplexes in vivo. Furthermore, the validity of each editing event was confirmed by sequencing the same regions of mRNA from worms that lack A-to-I editing. This analysis identified a large number of editing sites that can occur within each 3' UTR, but interestingly, each individual transcript contained only a small fraction of these A-to-I editing events. In addition, editing patterns were not random, indicating that an editing event can affect the efficiency of editing at subsequent @entity41931 . Furthermore, we identified specific sites that can be both positively and negatively correlated with additional sites leading to mutually exclusive editing patterns. These results suggest that editing in noncoding regions is selective and hyper-editing of cellular RNAs is rare.

title: Noncoding regions of XXXX mRNA undergo selective @entity859 to @entity14572 deamination and contain a small number of editing sites per transcript.

answer: @entity2199 :: (6239,Species) :: ['C. elegans']


abstract: UNASSIGNED: ADARs ( @entity859 deaminases that act on RNA) "edit" RNA by converting @entity41931 to @entity39859 within double-stranded regions. The primary targets of ADARs are long duplexes present within noncoding regions of mRNAs, such as introns and 3' untranslated regions (UTRs). Because @entity859 and @entity14572 have different base-pairing properties, editing within these regions can alter splicing and recognition by small RNAs. However, despite numerous studies identifying multiple editing sites in these genomic regions, little is known about the extent to which editing sites co-occur on individual transcripts or the functional output of these combinatorial editing events. To begin to address these questions, we performed an ultra-deep sequencing analysis of 4 @entity2199 3' UTRs that are known ADAR targets. Synchronous editing events were determined for the long duplexes in vivo. Furthermore, the validity of each editing event was confirmed by sequencing the same regions of mRNA from worms that lack A-to-I editing. This analysis identified a large number of editing sites that can occur within each 3' UTR, but interestingly, each individual transcript contained only a small fraction of these A-to-I editing events. In addition, editing patterns were not random, indicating that an editing event can affect the efficiency of editing at subsequent @entity41931 . Furthermore, we identified specific sites that can be both positively and negatively correlated with additional sites leading to mutually exclusive editing patterns. These results suggest that editing in noncoding regions is selective and hyper-editing of cellular RNAs is rare.

title: Noncoding regions of @entity2199 mRNA undergo selective @entity859 to XXXX deamination and contain a small number of editing sites per transcript.

answer: @entity14572 :: (MESH:D007288,Chemical) :: ['inosine']


abstract: Increasing evidence suggests that a brain-gut-microbiome axis exists, which has the potential to play a major role in modulating behaviour. However, the role of this axis in cognition remains relatively unexplored. Probiotics, which are commensal bacteria offering potential health benefit, have been shown to decrease @entity148 , @entity308 and @entity3825 -related behaviours. In this study, we investigate the potential of two Bifidobacteria strains to modulate cognitive processes and @entity3825 sensitivity. Adult male BALB/c @entity19 were fed daily for 11 weeks with @entity13854 1714, @entity14914 1205 or vehicle treatment. Starting at week 4, animals were behaviourally assessed in a battery of tests relevant to different aspects of cognition, as well as locomotor activity and @entity3825 . In the object recognition test, @entity13854 1714-fed @entity19 discriminated between the two objects faster than all other groups and @entity14914 1205-fed @entity19 discriminated faster than vehicle animals. In the Barnes maze, @entity13854 1714-treated @entity19 made fewer errors than other groups, suggesting a better learning. In the fear conditioning, @entity13854 1714-treated group also showed better learning and memory, yet presenting the same extinction learning profile as controls. None of the treatments affected visceral sensitivity. Altogether, these data suggest that @entity13854 1714 had a positive impact on cognition and also that the effects of individual Bifidobacteria strains do not generalise across the species. Clinical validation of the effects of probiotics on cognition is now warranted.

title: Bifidobacteria modulate cognitive processes in an anxious XXXX strain.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity3825 :: ('MESH:D059265', 'Disease') :: ['visceral pain']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: BACKGROUND: Recurrence of @entity704 even after complete resection is common, but the relapse patterns remain controversial. This study aimed to define the patterns and predictors of relapse after complete resection of @entity704 . METHODS: A single-institution retrospective study was performed with 331 @entity1 who underwent radical resection of @entity704 between 1991 and 2012. RESULTS: After a median follow-up of 59months, the recurrence rate was 6.9% (23/331). Relapse occurred in 23 @entity1 with the pleura (14) and @entity5 bed (6) as the most common sites of recurrence. According to the definitions of the International Thymic Malignancy Interest Group, 10 (43.5%) @entity1 had local relapse, 15 (65.2%) had regional relapse, 10 (43.5%) had distant relapse. The difference in survival following relapse between lung and regional relapse was statistically significant (P=0.027) but that between lung and distant relapse was not (P=0.808). The recurrence rates correlated with the initial Masaoka stage. Further, recurrence also correlated with World Health Organization (WHO) @entity5 type. The recurrence-free survival rates in @entity1 with @entity5 size    8cm were worse than those of @entity1 with @entity5 size <8cm (P=0.007). @entity5 size was also correlated with stage (r=0.110). As @entity5 becomes larger, the stage is more advanced (P=0.023). Multivariate analysis showed that Masaoka stage (P=0.005), @entity5 size (P=0.033), and WHO histological type (P=0.046) were predictive factors of relapse. CONCLUSION: Regional recurrence is the most common relapse pattern but local and distant relapse are also common. Advanced Masaoka stage, larger @entity5 size, and type B3 are risk factors of recurrence. Lung relapse should be considered distant relapse. Further, @entity5 size was correlated with Masaoka stage and therefore should be considered in the staging system.

title: Patterns and predictors of recurrence after radical resection of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor']

entities_list: @entity704 :: ('MESH:D013945', 'Disease') :: ['thymoma', 'thymomas']

answer: @entity704 :: (MESH:D013945,Disease) :: ['thymoma']


abstract: OBJECTIVES: To compare the clinical characteristics of Native Hawaiians (NH) and other Pacific Islanders (PI) who are hospitalized with @entity385 . DESIGN: Retrospective, cross-sectional analysis of medical records. SETTING: Tertiary, Primary @entity64 Center in Honolulu, Hawaii. @entity1 : Consecutive @entity1 with race/ethnicity identified as NH or PI who were hospitalized for @entity385 between January 2006 and December 2012. OUTCOME MEASURES: Age, sex, cardiovascular risk factors, intravenous tissue plasminogen activator (IV-tPA) utilization rate and hospital length of stay. RESULTS: A total of 561 @entity1 (57% NH and 43% PI) were studied. PI were younger (59    13 years vs 62    14 years, P = .002), had higher prevalence of @entity6 (58% vs 41%, P < .0001) and prosthetic valve (6% vs 2%, P = .007), lower prevalence of smoking (14% vs 21%, P = .03), lower HDL @entity165 (38    11 mg/dL vs 41    13 mg/dL, P = .004), and higher discharge diastolic blood pressure (79    15 vs 76 mm Hg    14 mm Hg, P = .04) compared to NH. No difference was seen in other cardiovascular risk factors. The IV-tPA utilization rate (5% vs 6%, P = .48) and the hospital length of stay (10    17 days vs 10    49 days, P = .86) were not different between the two groups. CONCLUSION: Native Hawaiians and other Pacific Islanders with @entity385 have modestly different age of @entity64 presentation and burden of risk factors compared to each other. Disaggregating these two racial groups may be important to unmask any potential clinical differences in future studies.

title: XXXX Disparities: Disaggregating Native Hawaiians from other Pacific Islanders.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'Stroke']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['Stroke']


abstract: Apoptosis of osteoblasts induced by glucocorticoid (GC) has been identified as a main cause of @entity170 , @entity604 and @entity174 , and the oxidative stress was found as an important contributor. Therefore, natural or synthetic agents with antioxidant activities can antagonize GCs-induced apoptosis in osteoblasts, and thus demonstrate the potential application to reverse @entity170 . In this study, we showed that, indole-3-carbinol ( @entity71299 ), a natural product found in broadly consumed plants of the Brassica genus, could block the cytotoxic effects of dexamethasone (Dex), and elucidated the underlying molecular mechanisms. Firstly, we showed that, I3C could effectively suppress Dex-induced @entity137 and apoptotic cell death in osteoblastic cells, as evidenced by the decrease in Sub-G1 cell population. Treatment of the cells with Dex resulted in activation of caspase-3/-8/-9 and subsequent cleavage of @entity9190 , which was also effectively blocked by co-incubation of I3C. Moreover, exposure to Dex triggered a rapid onset and time-dependent superoxide overproduction in osteoblastic cells, which was effectively suppressed by addition of I3C. Excess intracellular ROS induced by Dex significantly suppressed the expression levels of @entity13791 and the downstream effectors, @entity13975 and @entity5878 , but these changes could be reversed by I3C. Knockdown of @entity13791 using siRNA silencing technique significantly reversed the protective effects of I3C against Dex-induced apoptosis and ROS generation. Taken together, I3C can reverse @entity137 of Dex through blocking ROS overproduction and enhancement of @entity13791 expression. This study may provide a safe and good strategy for molecular intervention of GCs-induced @entity170 by using natural products.

title: Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated XXXX pathway.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity71299 :: ('p|SUB|I|3|C', 'ProteinMutation') :: ['I3C']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

answer: @entity13791 :: (4780,Gene) :: ['Nrf2']


abstract: UNASSIGNED: Breast cancer @entity3 is the leading cause of @entity5 in @entity1 worldwide. Collagen in the @entity5 microenvironment plays a crucial role in regulating @entity5 progression. We have shown that type III collagen (Col3), a component of @entity5 stroma, regulates myofibroblast differentiation and scar formation after cutaneous injury. During the course of these wound-healing studies, we noted that @entity5 developed at a higher frequency in Col3(+/-) @entity19 compared to wild-type littermate controls. We, therefore, examined the effect of Col3 deficiency on @entity5 behavior, using the @entity19 @entity189 cell line 4T1. Notably, @entity5 volume and pulmonary metastatic burden after orthotopic injection of 4T1 cells were increased in Col3(+/-) @entity19 compared to Col3(+/+) littermates. By using @entity19 (4T1) and @entity1 (MDA-MB-231) @entity0 cells grown in Col3-poor and Col3-enriched microenvironments in  vitro, we found that several major events of the metastatic process were suppressed by Col3, including adhesion, invasion, and migration. In addition, Col3 deficiency increased proliferation and decreased apoptosis of 4T1 cells both in  vitro and in @entity5 in  vivo. Mechanistically, Col3 suppresses the procarcinogenic microenvironment by regulating stromal organization, including density and alignment of fibrillar collagen and myofibroblasts. We propose that Col3 plays an important role in the @entity5 microenvironment by suppressing @entity3 -promoting characteristics of the @entity5 -associated stroma.

title: Type III Collagen Directs Stromal Organization and Limits @entity3 in a @entity19 Model of XXXX .

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'cancer-related deaths', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['mammary carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']


abstract: UNASSIGNED: Breast cancer @entity3 is the leading cause of @entity5 in @entity1 worldwide. Collagen in the @entity5 microenvironment plays a crucial role in regulating @entity5 progression. We have shown that type III collagen (Col3), a component of @entity5 stroma, regulates myofibroblast differentiation and scar formation after cutaneous injury. During the course of these wound-healing studies, we noted that @entity5 developed at a higher frequency in Col3(+/-) @entity19 compared to wild-type littermate controls. We, therefore, examined the effect of Col3 deficiency on @entity5 behavior, using the @entity19 @entity189 cell line 4T1. Notably, @entity5 volume and pulmonary metastatic burden after orthotopic injection of 4T1 cells were increased in Col3(+/-) @entity19 compared to Col3(+/+) littermates. By using @entity19 (4T1) and @entity1 (MDA-MB-231) @entity0 cells grown in Col3-poor and Col3-enriched microenvironments in  vitro, we found that several major events of the metastatic process were suppressed by Col3, including adhesion, invasion, and migration. In addition, Col3 deficiency increased proliferation and decreased apoptosis of 4T1 cells both in  vitro and in @entity5 in  vivo. Mechanistically, Col3 suppresses the procarcinogenic microenvironment by regulating stromal organization, including density and alignment of fibrillar collagen and myofibroblasts. We propose that Col3 plays an important role in the @entity5 microenvironment by suppressing @entity3 -promoting characteristics of the @entity5 -associated stroma.

title: Type III Collagen Directs Stromal Organization and Limits XXXX in a @entity19 Model of @entity0 .

answer: @entity3 :: (MESH:D009362,Disease) :: ['Metastasis']


abstract: UNASSIGNED: Breast cancer @entity3 is the leading cause of @entity5 in @entity1 worldwide. Collagen in the @entity5 microenvironment plays a crucial role in regulating @entity5 progression. We have shown that type III collagen (Col3), a component of @entity5 stroma, regulates myofibroblast differentiation and scar formation after cutaneous injury. During the course of these wound-healing studies, we noted that @entity5 developed at a higher frequency in Col3(+/-) @entity19 compared to wild-type littermate controls. We, therefore, examined the effect of Col3 deficiency on @entity5 behavior, using the @entity19 @entity189 cell line 4T1. Notably, @entity5 volume and pulmonary metastatic burden after orthotopic injection of 4T1 cells were increased in Col3(+/-) @entity19 compared to Col3(+/+) littermates. By using @entity19 (4T1) and @entity1 (MDA-MB-231) @entity0 cells grown in Col3-poor and Col3-enriched microenvironments in  vitro, we found that several major events of the metastatic process were suppressed by Col3, including adhesion, invasion, and migration. In addition, Col3 deficiency increased proliferation and decreased apoptosis of 4T1 cells both in  vitro and in @entity5 in  vivo. Mechanistically, Col3 suppresses the procarcinogenic microenvironment by regulating stromal organization, including density and alignment of fibrillar collagen and myofibroblasts. We propose that Col3 plays an important role in the @entity5 microenvironment by suppressing @entity3 -promoting characteristics of the @entity5 -associated stroma.

title: Type III Collagen Directs Stromal Organization and Limits @entity3 in a XXXX Model of @entity0 .

answer: @entity19 :: (10090,Species) :: ['Murine']


abstract: A case of dural @entity7026 manifested during pregnancy was reported. On December 28, 1979, a 28-year-old primipara, suddenly developed @entity10 , @entity390 and @entity391 at the 8th month of her pregnancy and soon after became unconscious. She was transferred by ambulance to our hospital. On admission she was @entity772 exhibiting @entity2003 . The blood pressure was 126/76 mmHg and the pulse rate 97 per minute and regular. Right pupil was dilated and did not react to light. CT scan revealed a subdural @entity1410 on the right side and @entity1779 in the right middle fossa. Angiography demonstrated a dural @entity7026 in the right anterior middle fossa fed by the middle meningeal artery. @entity1211 consisted of the superficial sylvian vein directed toward the superior sagittal sinus. The @entity1 was in no @entity558 , so we only removed subdural @entity1410 , decompressed externally and ligated the external carotid artery. The postoperative course was uneventful, the anisocoria was diminished, and the consciousness improved up to @entity911 , but the @entity1269 remained. Two months later a 2,760g baby @entity1 was born by Caesarean section without accident. But two weeks later, suddenly she had generalized @entity410 and became @entity772 . CT scan revealed an @entity1779 in the middle fossa again. Second operation was performed, and the nidus was electrocoagulated and removed together with the @entity1410 . The postoperative course was also uneventful. At present, one and a half years after operation, no symptom of recurrence is observed. @entity1779 and dural @entity7026 in pregnancy were discussed and the reports in the literature were reviewed.

title: [A case of dural XXXX during pregnancy (author's transl)].

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'patient']

entities_list: @entity558 :: ('MESH:C536528', 'Disease') :: ['good condition']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['decerebrate rigidity']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsions']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['right hemiparesis']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity772 :: ('MESH:D003128', 'Disease') :: ['comatose']

entities_list: @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['Venous drainage']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['Intracerebral hemorrhage', 'intracerebral hematoma']

answer: @entity7026 :: (MESH:D002538,Disease) :: ['AVM']


abstract: BACKGROUND: Evidence suggests that a significant number of @entity1 receive less than optimal management of procedure-related @entity158 . OBJECTIVES: To determine if there was a difference in the perceived @entity158 associated with a venipuncture procedure in a group of pediatric @entity1 based on the preparatory intervention used during the procedure and, to determine if age, sex, or ethnic group were associated with the effectiveness of the preparatory interventions used. DESIGN: A quasi-experimental, 3*4 factorial design was used. SETTING: @entity1 were recruited from a non-profit, regional hospital in the southeast United States. @entity1 : @entity1 were recruited from @entity1 between the ages of 18 months and 17 years who were admitted to the facility. Criteria for inclusion was the first needle stick during admission with a parent or guardian present, English as the primary language. Potential @entity1 were excluded if they had previous experience with any of the preparatory interventions, were sedated, unconscious, hemodynamically unstable, developmentally delayed for their age, or had a known chronic condition. Of the 285 @entity1 consented to participate, 173 @entity1 completed the process including 35 (20.2%) toddlers, 34(19.7%) preschool and 65 (37.6%) school age @entity1 , and 39 (22.5%) adolescents. There were 77 (44.5%) females and 96 (55.5%) males; and 101 (58.4%) non-Hispanic white @entity1 and 72 (41.6%) minority @entity1 . METHODS: @entity1 were randomized to one of three treatment interventions. There was a purposeful effort to include representative numbers of each age group, ethnic group, and sex and in each treatment group. Measures of @entity158 before and after the procedure included an observational measure completed by the parent/guardian and a self-report measure completed by the two older age groups. FINDINGS: There were no statistically significant differences among treatment groups based on the observational measures of @entity158 or the self-report measures of @entity158 . There was a statistically significant interaction between ethnic group and treatment group (p=0.006) based on the observational measure of @entity158 which was also found between ethnic group and treatment group (p=.04) based on self-report scores in school age @entity1 and adolescents. CONCLUSION: Findings support the use of both mechanical vibration and topical anesthetic as effective in @entity1 regardless of age group or sex. Further, the interaction between ethnic group and treatment contributes to a growing body of knowledge that suggests ethnic group is an important factor in the @entity158 response and requires further study in an effort to better customize approaches to @entity158 management in @entity1 .

title: Mitigating procedural XXXX during venipuncture in a pediatric population: A randomized factorial study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'patients', 'Children', 'Participants', 'PARTICIPANTS']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: UNASSIGNED: The present study reports the case of a 68-year-old male @entity1 who presented to Tokyo Rosai Hospital for the treatment of @entity5881 . A high density was observed in liver segment S2, while a @entity5 , 30 mm in size, exhibiting a low density was observed in the delayed phase upon contrast-enhanced computed tomography (CT), which was performed prior to admission. The @entity5 appeared slightly poorly defined upon abdominal ultrasound and was observed as a 30 mm low-echoic nodule that was internally heterogeneous. A 5-mm thick contrast enhancement effect was observed in the @entity5 border in the vascular phase on Sonazoid contrast-enhanced ultrasonography, while a defect in the entire @entity5 was observed in the post-vascular phase. @entity1282 had commenced three months prior to presentation and a weight loss of ~3 kg was observed. Therefore, the @entity1 was admitted to Tokyo Rosai Hospital due to the presence of a @entity99 , and to undergo a close inspection of the cause of the @entity5 . Upon close inspection, it was determined that the weight loss and aphagia were caused by progressive @entity10296 . A contrast-enhanced CT was performed on post-admission day 29 as a follow-up regarding the @entity99 . As a result, although no change in the @entity5 size was observed, the contrast enhancement in the @entity5 borderline had disappeared. Necrosis of the @entity5 was considered. However, as viable persistence of the @entity5 could not be excluded, a hepatic left lobe excision was performed. The @entity1 was diagnosed with @entity157 ( @entity157 ) based on the morphology of the cellular @entity39 . In addition, occlusion due to @entity715 was observed within the blood vessels passing inside the fibrous capsule. It was hypothesized that the formation of a thick fibrous capsule and occlusion due to @entity715 in the feeding vessel were possibly involved as the cause of complete spontaneous @entity39 . Written informed consent was obtained from the @entity1 .

title: XXXX : A case report and review of the literature.

entities_list: @entity5881 :: ('MESH:D008108', 'Disease') :: ['alcoholic liver disease']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumor']

entities_list: @entity10296 :: ('MESH:D010244', 'Disease') :: ['bulbar paralysis']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['Dysphagia']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic tumor']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

answer: @entity157 :: (MESH:D006528,Disease) :: ['Spontaneous complete necrosis of hepatocellular carcinoma']


abstract: UNASSIGNED: @entity17539 is an extremely rare disease that, at present, has not been well characterized. The etiology, diagnosis and treatment of this @entity189 remain poorly understood, particularly in the Chinese population. The aim of the present study was to discuss the methods of diagnosis and treatment of @entity17539 in the Chinese population. The clinical and pathological data of 10 @entity1 with @entity17539 were analyzed alongside a literature review. All the @entity5 were exophytic papillary lesions, ranging between 0.4 and 4 cm in diameter and all 10 @entity1 underwent partial penectomy with @entity5 -negative surgical margins. None of the 10 @entity1 underwent ilioinguinal lymphadenectomy. All @entity1 were regularly followed up for 0.7-9 years, which revealed that no @entity1 developed recurrence, and only one case resulted in mortality due to unassociated causes. It was found that @entity17539 is a well-differentiated disease with low malignant potential and locally aggressive features, which seldom metastasizes to regional lymph nodes or distant regions. However, misdiagnosis may occur due to an incorrect biopsy. Favorable outcomes can be achieved by surgery, even without any adjuvant therapy, but @entity1 should be carefully followed up.

title: Diagnosis and treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity17539 :: ('MESH:D010412', 'Disease') :: ['penile verrucous carcinoma', 'Penile verrucous carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

answer: @entity17539 :: (MESH:D010412,Disease) :: ['penile verrucous carcinoma']


abstract: BACKGROUND: In @entity1 affected by @entity253 deemed unsuitable for pancreatoduodenectomy, biliary diversion is the only proposable option. Defined goals of this treatment are: relief from @entity1087 preventing its related complications, reduction of in-hospital stay and adequate control of @entity158 . Palliation can be obtained either by surgical or conservative procedures (endoscopic stenting or percutaneous treatment). Considering early complications' incidence, surgical approach has always been reserved for low surgical risk @entity1 with longer survival perspectives, while recently developed long-lasting patency stents enlarged mini-invasive application resort. Comparative studies on these therapeutic options favour the conservative one in respect of conventional open surgery, but data on minimally invasive surgery to pursue palliative aims are lacking. We present our six-years casuistic and results referring to laparoscopic biliary diversions. METHODS: We analyzed results obtained in distal biliary neoplastic obstruction management between December 2008 and November 2014. During this period, selected @entity1 considered unsuitable for pancreatoduodenectomy were scheduled to receive a laparoscopic biliary decompression. Perioperative variables and 30-days postoperative outcomes have been prospectively collected. RESULTS: In the six-years period, 12 @entity1 affected by distal biliary neoplastic obstruction were submitted to laparoscopic palliative bypass. Four procedures were proposed for @entity5 , one for advanced @entity5 and seven for @entity788 . Ten hepatico-jejunal bypasses and two choledochoduodenostomies have been performed. No conversions to open surgery were encountered in this series. Main operative time was 85 min, main @entity190 was 75 ml and main hospitalization was 4.5 days. According to Clavien Dindo Classification one class II and one class IIIb complications occurred. CONCLUSIONS: Although the restricted number of @entity1 , our results suggest that laparoscopic biliary bypass could be a valid option in managing @entity253 , resulting in low perioperative morbidity, effective long term palliation of symptoms and improved quality of life.

title: Laparoscopic perspectives for XXXX .

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic head cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['periampullary cancer', 'distal biliary cancer']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity253 :: ('MESH:D001660', 'Disease') :: ['distal biliary obstructions', 'distal biliary obstruction']

answer: @entity253 :: (MESH:D001660,Disease) :: ['distal biliary obstruction']


abstract: BACKGROUND: @entity0 is the most common @entity5 in @entity1 . @entity1486 (PSA) is a marker of prostate gland malignancy, which has been considered in cases with @entity0 in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHODS: In this case-control study, ninety @entity1 with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with Histological grade and conditions of vascular and perinural invasion, status of @entity5 receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut-off point for total PSA to differentiate benign and malignant masses was 0.31 with sensitivity and specificity of 100%, 100% (area under the curve [AUC] =1, P < 0.001) and the best cut-off point for free PSA to differentiate benign and malignant masses was 0.19 with sensitivity and specificity of 100% and 100% (AUC = 1, P < 0.001). After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23    0.1 vs. 0.3    0.08, P < 0.001). CONCLUSIONS: Serum PSA level could be applied for differentiating benign and malignant breast masses.

title: Is Serum XXXX a Diagnostic Marker for Benign and Malignant @entity0 in @entity1 ?

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['hormonal tumor', 'cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer']

entities_list: @entity1486 :: ('354', 'Gene') :: ['Prostate-specific antigen']

answer: @entity1486 :: (354,Gene) :: ['Prostate-specific Antigen']


abstract: BACKGROUND: @entity0 is the most common @entity5 in @entity1 . @entity1486 (PSA) is a marker of prostate gland malignancy, which has been considered in cases with @entity0 in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHODS: In this case-control study, ninety @entity1 with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with Histological grade and conditions of vascular and perinural invasion, status of @entity5 receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut-off point for total PSA to differentiate benign and malignant masses was 0.31 with sensitivity and specificity of 100%, 100% (area under the curve [AUC] =1, P < 0.001) and the best cut-off point for free PSA to differentiate benign and malignant masses was 0.19 with sensitivity and specificity of 100% and 100% (AUC = 1, P < 0.001). After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23    0.1 vs. 0.3    0.08, P < 0.001). CONCLUSIONS: Serum PSA level could be applied for differentiating benign and malignant breast masses.

title: Is Serum @entity1486 a Diagnostic Marker for Benign and Malignant XXXX in @entity1 ?

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast Tumors']


abstract: BACKGROUND: @entity0 is the most common @entity5 in @entity1 . @entity1486 (PSA) is a marker of prostate gland malignancy, which has been considered in cases with @entity0 in recent years. The goal of this study was to determine total and free PSA levels in cases with malignant and benign breast lesions. METHODS: In this case-control study, ninety @entity1 with histological proved malignant breast masses and 90 with benign breast masses were enrolled. Total and free PSA levels along with Histological grade and conditions of vascular and perinural invasion, status of @entity5 receptors, immune-histo-chemistry markers recorded for all cases. Total and free PSA levels were assessed after treatment in cases with malignant masses. RESULTS: Total and free PSA levels were significantly higher in cases with malignant masses. The best cut-off point for total PSA to differentiate benign and malignant masses was 0.31 with sensitivity and specificity of 100%, 100% (area under the curve [AUC] =1, P < 0.001) and the best cut-off point for free PSA to differentiate benign and malignant masses was 0.19 with sensitivity and specificity of 100% and 100% (AUC = 1, P < 0.001). After treatment, mean free PSA level was significantly lower than free PSA before treatment (0.23    0.1 vs. 0.3    0.08, P < 0.001). CONCLUSIONS: Serum PSA level could be applied for differentiating benign and malignant breast masses.

title: Is Serum @entity1486 a Diagnostic Marker for Benign and Malignant @entity0 in XXXX ?

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: OBJECTIVES: The objective was to explore which @entity1 characteristics are associated with repeat @entity341 ( @entity341 ) visitation within 30  days of @entity341 discharge for @entity1 presenting with @entity490 . METHODS: A retrospective, observational study was conducted at a single, @entity7298 . A consecutive sample of adult @entity1 with a chief complaint of @entity490 from January 2010 through December 2010 who were discharged following @entity341 evaluation were included in the analysis. A logistic regression model was used to determine which @entity1 -level factors, including computed tomography (CT) utilization, were associated with the primary outcome of @entity341 revisit within 30  days. RESULTS: Of 80,619 total @entity341 @entity1 visits during the study period, 3,928 @entity341 discharges with a chief complaint of @entity490 were included. A total of 487 (12.4%) @entity1 revisited the @entity341 within 30  days. No deaths were recorded. CT imaging was associated with a lower 30-day revisit rate (odds ratio [OR]  = 0.69, 95% confidence interval [CI]  =  0.55 to 0.87) after controlling for multiple other @entity1 -level factors associated with revisits. Increasing age (OR  = 1.01, 95% CI  =  1.00 to 1.02), increasing triage @entity158 scores (OR  = 1.13, 95% CI  =  1.08 to 1.18), elevated triage heart rate (OR  = 1.42, 95% CI  =  1.07 to 1.89), low @entity1372 levels (OR  = 1.56, 95% CI  =  1.07 to 2.23), and @entity417 (OR  = 1.42, 95% CI  =  1.04 to 1.95) were all associated with increased rate of return. CONCLUSIONS: Performance of an abdominal CT was associated with fewer 30-day revisits, suggesting that future measures of "imaging appropriateness" and " @entity341 overuse" consider downstream utilization of health care resources in addition to the index visit.

title: Abdominal Computed Tomography Utilization and 30-day Revisitation in Emergency Department @entity1 Presenting With XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity7298 :: ('MESH:D006963', 'Disease') :: ['academic, urban ED with over 85,000 annual visits']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

answer: @entity490 :: (MESH:D015746,Disease) :: ['Abdominal Pain']


abstract: OBJECTIVES: The objective was to explore which @entity1 characteristics are associated with repeat @entity341 ( @entity341 ) visitation within 30  days of @entity341 discharge for @entity1 presenting with @entity490 . METHODS: A retrospective, observational study was conducted at a single, @entity7298 . A consecutive sample of adult @entity1 with a chief complaint of @entity490 from January 2010 through December 2010 who were discharged following @entity341 evaluation were included in the analysis. A logistic regression model was used to determine which @entity1 -level factors, including computed tomography (CT) utilization, were associated with the primary outcome of @entity341 revisit within 30  days. RESULTS: Of 80,619 total @entity341 @entity1 visits during the study period, 3,928 @entity341 discharges with a chief complaint of @entity490 were included. A total of 487 (12.4%) @entity1 revisited the @entity341 within 30  days. No deaths were recorded. CT imaging was associated with a lower 30-day revisit rate (odds ratio [OR]  = 0.69, 95% confidence interval [CI]  =  0.55 to 0.87) after controlling for multiple other @entity1 -level factors associated with revisits. Increasing age (OR  = 1.01, 95% CI  =  1.00 to 1.02), increasing triage @entity158 scores (OR  = 1.13, 95% CI  =  1.08 to 1.18), elevated triage heart rate (OR  = 1.42, 95% CI  =  1.07 to 1.89), low @entity1372 levels (OR  = 1.56, 95% CI  =  1.07 to 2.23), and @entity417 (OR  = 1.42, 95% CI  =  1.04 to 1.95) were all associated with increased rate of return. CONCLUSIONS: Performance of an abdominal CT was associated with fewer 30-day revisits, suggesting that future measures of "imaging appropriateness" and " @entity341 overuse" consider downstream utilization of health care resources in addition to the index visit.

title: Abdominal Computed Tomography Utilization and 30-day Revisitation in Emergency Department XXXX Presenting With @entity490 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: PURPOSE OF THE STUDY: The study objective was to understand providers' perceptions regarding identifying and treating older adults with @entity933 , a common complication of @entity697 in @entity1 with @entity303 , in the pre-hospital and emergency department environments. DESIGN AND METHODS: The authors conducted structured focus group interviews with separate groups of emergency medical services staff, emergency nurses, and emergency physicians. Recordings of each session were transcribed, coded, and analyzed for themes with representative supporting quotations identified. RESULTS: Providers shared that the busy emergency department environment was the largest challenge to @entity933 recognition and treatment. When describing @entity933 , @entity1 frequently detailed hyperactive features of @entity933 , rather than hypoactive features. @entity1 shared that they employed no clear diagnostic strategy for identifying the condition and that they used heterogeneous approaches to treat the condition. To improve care for older adults with @entity933 , emergency nurses identified the need for more training around the management of the condition. Emergency medical services providers identified the need for more support in managing @entity2146 @entity1 when in transport to the hospital and more guidance from emergency physicians on what information to collect from the @entity1 's home environment. Emergency physicians felt that @entity933 care would be improved if they could have baseline mental status data on their @entity1 and if they had access to a simple, accurate diagnostic tool for the condition. IMPLICATIONS: Emergency medical services providers, emergency nurses, and emergency physicians frequently encounter delirious @entity1 , but do not employ clear diagnostic strategies for identifying the condition and have varying levels of comfort in managing the condition. Clear steps should be taken to improve @entity933 care in the emergency department including the development of mechanisms to communicate @entity1 ' baseline mental status, the adoption of a systematized approach to recognizing @entity933 , and the institution of a standardized method to treat the condition when identified.

title: Emergency medical service, nursing, and physician providers' perspectives on XXXX identification and management.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient', 'Participants', 'persons']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute illness']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium']

answer: @entity933 :: (MESH:D003693,Disease) :: ['delirium']


abstract: UNASSIGNED: Several laboratories, including ours, have reported an overrepresentation of @entity2122 ( @entity2122 ) anomalies in @entity161 ( @entity161 ). How might this dysmorphology arise in a @entity75 ? Because the brain and face derive from shared embryologic primordia and morphogenetic forces, maldevelopmental processes may result in both @entity2122 and @entity75 . Our approach is 2-pronged. First, we have employed, for the first time in the study of @entity146 , objective measures of @entity2122 morphology that utilize an extensive normative database, permitting computation of standardized scores for each subject. Second, we have rendered these findings biologically interpretable by adopting principles of embryology in the analysis of dysmorphology. Dependent measures in this investigation focused on derivatives of specific @entity2085 and were contrasted among probands with @entity914 , their first-degree relatives, and normal controls (NC). Subject groups included @entity1 with a diagnosis of @entity161 (N = 39) or @entity162 with @entity716 features (N = 32), their clinically unaffected relatives (N = 82 and N = 41, respectively), and NC (N = 95) subjects. Anomalies involving derivatives of frontonasal and mandibular @entity2085 showed a clear association with @entity716 , as well as @entity1423 in relatives in both diagnostic groups. In contrast, one class of @entity2122 emerged only among @entity161 probands and their first-degree relatives: dysmorphology arising along the junction of the frontonasal and maxillary prominence derivatives, manifested as marked asymmetries. This class was not overrepresented among the BP @entity1 nor among their relatives, indicating that this dysmorphology appears to be specific to @entity161 and not a generalized feature of @entity716 . We discuss these findings in light of embryologic models that relate brain regions to specific @entity2122 areas.

title: Quantitative Measures of Craniofacial Dysmorphology in a Family Study of @entity161 and XXXX .

entities_list: @entity2122 :: ('MESH:D019465', 'Disease') :: ['CF', 'craniofacial', 'CF anomalies']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar (BP) disorder']

entities_list: @entity2085 :: ('MESH:D020964', 'Disease') :: ['embryonic primordia']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric disorders']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain dysmorphology', 'brain-based disorder']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['familial aggregation']

entities_list: @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorders']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'SZ']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic illness', 'psychotic', 'psychosis']

answer: @entity162 :: (MESH:D001714,Disease) :: ['Bipolar Illness']


abstract: UNASSIGNED: Several laboratories, including ours, have reported an overrepresentation of @entity2122 ( @entity2122 ) anomalies in @entity161 ( @entity161 ). How might this dysmorphology arise in a @entity75 ? Because the brain and face derive from shared embryologic primordia and morphogenetic forces, maldevelopmental processes may result in both @entity2122 and @entity75 . Our approach is 2-pronged. First, we have employed, for the first time in the study of @entity146 , objective measures of @entity2122 morphology that utilize an extensive normative database, permitting computation of standardized scores for each subject. Second, we have rendered these findings biologically interpretable by adopting principles of embryology in the analysis of dysmorphology. Dependent measures in this investigation focused on derivatives of specific @entity2085 and were contrasted among probands with @entity914 , their first-degree relatives, and normal controls (NC). Subject groups included @entity1 with a diagnosis of @entity161 (N = 39) or @entity162 with @entity716 features (N = 32), their clinically unaffected relatives (N = 82 and N = 41, respectively), and NC (N = 95) subjects. Anomalies involving derivatives of frontonasal and mandibular @entity2085 showed a clear association with @entity716 , as well as @entity1423 in relatives in both diagnostic groups. In contrast, one class of @entity2122 emerged only among @entity161 probands and their first-degree relatives: dysmorphology arising along the junction of the frontonasal and maxillary prominence derivatives, manifested as marked asymmetries. This class was not overrepresented among the BP @entity1 nor among their relatives, indicating that this dysmorphology appears to be specific to @entity161 and not a generalized feature of @entity716 . We discuss these findings in light of embryologic models that relate brain regions to specific @entity2122 areas.

title: Quantitative Measures of Craniofacial Dysmorphology in a Family Study of XXXX and @entity162 .

answer: @entity161 :: (MESH:D012559,Disease) :: ['Schizophrenia']


abstract: UNASSIGNED: @entity5132 is the most common @entity1 fungal pathogen, yet is a normal commensal resident of the @entity1 gut. @entity3158 levels in the gut are much higher than in air, and it is known that elevated @entity3158 concentration promotes @entity5132 cells to undergo a phenotypic switch from white to opaque phase. Wor1, the master regulator of opaque cell formation, is required for both the white-to-opaque transition and opaque maintenance. To elucidate the regulatory mechanism of Wor1, we set out to identify Wor1-interacting proteins using a yeast two-hybrid screen. A SUMO E3 ligase named Wos1 (Wor1 SUMO-ligase 1) was identified to interact with Wor1 and regulate Wor1 sumoylation. WOS1 expression is up-regulated in response to high @entity3158 , and the induction by @entity3158 is dependent on the transcription factor Flo8. Under high @entity3158 conditions, Wos1 is required for the white-to-opaque switch and acts downstream of Flo8. At atmospheric @entity3158 levels, over-expression of Wos1 enhances Wor1 sumoylation and promotes the white-to-opaque switch. Wor1 is found to be sumoylated at @entity376 385, and loss of this mark by point mutation leads to a defect in @entity3158 -mediated opaque cell induction. Together our genetic and biological data show that Wos1-mediated Wor1 sumoylation contributes to the regulation of @entity3158 -induced @entity62 as well as heritable maintenance of the opaque cell type.

title: Sumoylation of Wor1 by a novel SUMO E3 ligase controls cell fate in XXXX .

entities_list: @entity5132 :: ('5476', 'Species') :: ['Candida albicans', 'C. albicans']

entities_list: @entity376 :: ('CHEBI:25094', 'Chemical') :: ['lysine']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['white-to-opaque switching']

answer: @entity5132 :: (5476,Species) :: ['Candida albicans']


abstract: OBJECTIVE: To evaluate the effectiveness of biopsychosocial @entity14062 ( @entity14062 ) delivered by practice nurses in routine @entity6 care. DESIGN: A pragmatic cluster-randomised controlled trial within a hybrid effectiveness-implementation study design. Practice nurses were cluster-randomised. SETTING: A regional care group in the Netherlands consisting of 77 family practices. The study involved practice nurses (n=40) providing care to approximately 4000 @entity1 with @entity6 . @entity1 : @entity1 with @entity164 2 @entity6 (n=264) selected by a self-administered questionnaire aimed at measuring emotional distress and @entity6 -related reduced daily functioning. INTERVENTION: Practice nurses in the intervention arm (n=19) were trained to integrate @entity14062 into their routine consultations. @entity14062 included detection of @entity1 with emotional distress and reduced daily functioning, and supporting them when needed through problem solving and reattribution techniques. Practice nurses in the control arm (n=21) provided usual care. MAIN OUTCOME MEASURES: The primary outcome measure was a dichotomised score on a Visual Analogue Scale that measured the perceived effect of @entity6 on daily functioning. Secondary measures included @entity1 ' @entity6 , quality of life, autonomy and participation, self-efficacy, self-management and glycaemic control. Outcomes were measured at baseline and at 4-month and 12-month follow-ups. RESULTS: Only 16 of the 117 @entity1 in the intervention arm (14%) who were found eligible by the posted research-driven screening questionnaire were detected by their practice nurses. Extra consultations for the self-management support were delivered to only 11 study @entity1 . In the control arm, 147 @entity1 received usual care. Multilevel analyses showed no significant differences in outcomes between the intervention and control arms. CONCLUSIONS: @entity14062 in its present form was not effective. The research-driven screening to select trial @entity1 appeared to be inconsistent with nurse-led detection in routine practice. Adequate follow-up moments need to be built in to overcome barriers resulting from tension between the implementation and effectiveness parts of hybrid studies. TRIAL REGISTRATION NUMBER: Current Controlled Trials NTR2764.

title: Lessons learnt from a cluster-randomised trial evaluating the effectiveness of @entity14062 ( XXXX ) delivered by practice nurses in routine @entity6 care.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients', 'PARTICIPANTS']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes-related distress']

entities_list: @entity14062 :: ('MESH:D012652', 'Disease') :: ['Self-Management Support', 'SMS']

answer: @entity14062 :: (MESH:D012652,Disease) :: ['SMS']


abstract: OBJECTIVE: To evaluate the effectiveness of biopsychosocial @entity14062 ( @entity14062 ) delivered by practice nurses in routine @entity6 care. DESIGN: A pragmatic cluster-randomised controlled trial within a hybrid effectiveness-implementation study design. Practice nurses were cluster-randomised. SETTING: A regional care group in the Netherlands consisting of 77 family practices. The study involved practice nurses (n=40) providing care to approximately 4000 @entity1 with @entity6 . @entity1 : @entity1 with @entity164 2 @entity6 (n=264) selected by a self-administered questionnaire aimed at measuring emotional distress and @entity6 -related reduced daily functioning. INTERVENTION: Practice nurses in the intervention arm (n=19) were trained to integrate @entity14062 into their routine consultations. @entity14062 included detection of @entity1 with emotional distress and reduced daily functioning, and supporting them when needed through problem solving and reattribution techniques. Practice nurses in the control arm (n=21) provided usual care. MAIN OUTCOME MEASURES: The primary outcome measure was a dichotomised score on a Visual Analogue Scale that measured the perceived effect of @entity6 on daily functioning. Secondary measures included @entity1 ' @entity6 , quality of life, autonomy and participation, self-efficacy, self-management and glycaemic control. Outcomes were measured at baseline and at 4-month and 12-month follow-ups. RESULTS: Only 16 of the 117 @entity1 in the intervention arm (14%) who were found eligible by the posted research-driven screening questionnaire were detected by their practice nurses. Extra consultations for the self-management support were delivered to only 11 study @entity1 . In the control arm, 147 @entity1 received usual care. Multilevel analyses showed no significant differences in outcomes between the intervention and control arms. CONCLUSIONS: @entity14062 in its present form was not effective. The research-driven screening to select trial @entity1 appeared to be inconsistent with nurse-led detection in routine practice. Adequate follow-up moments need to be built in to overcome barriers resulting from tension between the implementation and effectiveness parts of hybrid studies. TRIAL REGISTRATION NUMBER: Current Controlled Trials NTR2764.

title: Lessons learnt from a cluster-randomised trial evaluating the effectiveness of XXXX ( @entity14062 ) delivered by practice nurses in routine @entity6 care.

answer: @entity14062 :: (MESH:D012652,Disease) :: ['Self-Management Support']


abstract: OBJECTIVE: To evaluate the effectiveness of biopsychosocial @entity14062 ( @entity14062 ) delivered by practice nurses in routine @entity6 care. DESIGN: A pragmatic cluster-randomised controlled trial within a hybrid effectiveness-implementation study design. Practice nurses were cluster-randomised. SETTING: A regional care group in the Netherlands consisting of 77 family practices. The study involved practice nurses (n=40) providing care to approximately 4000 @entity1 with @entity6 . @entity1 : @entity1 with @entity164 2 @entity6 (n=264) selected by a self-administered questionnaire aimed at measuring emotional distress and @entity6 -related reduced daily functioning. INTERVENTION: Practice nurses in the intervention arm (n=19) were trained to integrate @entity14062 into their routine consultations. @entity14062 included detection of @entity1 with emotional distress and reduced daily functioning, and supporting them when needed through problem solving and reattribution techniques. Practice nurses in the control arm (n=21) provided usual care. MAIN OUTCOME MEASURES: The primary outcome measure was a dichotomised score on a Visual Analogue Scale that measured the perceived effect of @entity6 on daily functioning. Secondary measures included @entity1 ' @entity6 , quality of life, autonomy and participation, self-efficacy, self-management and glycaemic control. Outcomes were measured at baseline and at 4-month and 12-month follow-ups. RESULTS: Only 16 of the 117 @entity1 in the intervention arm (14%) who were found eligible by the posted research-driven screening questionnaire were detected by their practice nurses. Extra consultations for the self-management support were delivered to only 11 study @entity1 . In the control arm, 147 @entity1 received usual care. Multilevel analyses showed no significant differences in outcomes between the intervention and control arms. CONCLUSIONS: @entity14062 in its present form was not effective. The research-driven screening to select trial @entity1 appeared to be inconsistent with nurse-led detection in routine practice. Adequate follow-up moments need to be built in to overcome barriers resulting from tension between the implementation and effectiveness parts of hybrid studies. TRIAL REGISTRATION NUMBER: Current Controlled Trials NTR2764.

title: Lessons learnt from a cluster-randomised trial evaluating the effectiveness of @entity14062 ( @entity14062 ) delivered by practice nurses in routine XXXX care.

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: PURPOSE: We report a case of a large three-level @entity421 infiltrating the adjacent aorta. This is the first case in which a combined modified three-level en bloc corpectomy with resection and replacement of the adjacent aorta was successful as a part of interdisciplinary curative treatment. METHODS: Case report. RESULTS: The surgical procedure was performed as a two-step treatment. A heart lung machine (HLM) was not used, in order to avoid cerebral and spinal @entity63 and to decrease the risk of @entity5 metastases. Instead, a bypass from the left subclavian artery the distal descending aorta was used. We modified the en bloc corpectomy procedure, leaving a dorsal segment of the vertebral bodies to enable rapid surgery. The procedure was successful and the en bloc resection of the vertebral body with aortal resection could be achieved. Except for pallhypesthesia in the left dermatomes Th7-Th10, the @entity1 does not have any postoperative @entity51 . CONCLUSION: Combined corpectomy with aortic replacement should be considered as a reasonable option in the curative treatment of @entity421 with consideration of the immense surgical risks. The use of an HLM is not necessary, especially considering the inherent risk of @entity5 metastases. Modified corpectomy leaving a dorsal vertebral body segment was considered a reasonable variation since @entity5 -free margins could still be expected.

title: Combined modified en bloc corpectomy with replacement of the aorta in curative interdisciplinary treatment of a large XXXX infiltrating the aorta.

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'hematogenous tumor']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurologic deficits']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma', 'spinal osteosarcoma']

answer: @entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']


abstract: CLINICAL PROBLEM: We diagnosed 8 @entity1 with late-stage @entity340 ( @entity340 ) between 1 and 14 years of age. Five @entity1 complained of symptoms related to @entity409 . The other 3 @entity1 required urethrocystoscopy for other reasons ( @entity2650 fistulae, difficulty with catheterisation and high-grade @entity3025 [ @entity3025 ]). A second review of the first 2 @entity1 ' medical history showed @entity66 . All @entity1 underwent preoperative ultrasonography: 3 @entity1 had normal results and 5 had @entity8 . The diagnosis was reached through voiding cystourethrogram (VCUG), and 4 @entity1 underwent urodynamic studies. The diagnosis was confirmed by urethrocystoscopy, performing valve electrofulguration. We performed urethrocystoscopy during the check-ups at 3-6 weeks and observed no @entity850 . The symptoms disappeared for all @entity1 after 20 months of follow-up. The @entity1 with @entity3025 was cured. The ultrasounds showed no progression of the renal involvement and showed improvement in the vesical involvement. The velocimetries during check-ups presented curves within normal ranges. DISCUSSION: Most @entity1 with @entity340 are diagnosed through ultrasound during the neonatal period. Some @entity1 present @entity340 at later ages with diverse symptoms, which impedes its diagnosis. We should suspect @entity340 in male @entity1 with symptoms of @entity409 , either when they have normal or pathological results from ultrasounds or VCUG. We recommend performing urethrocystoscopy to rule out @entity11044 .

title: Late diagnosis of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal or vesical disorders']

entities_list: @entity2650 :: ('MESH:D007021', 'Disease') :: ['hypospadias']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['voiding dysfunction symptoms']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['voiding dysfunction']

entities_list: @entity3025 :: ('MESH:D014718', 'Disease') :: ['vesicoureteral reflux', 'VUR']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['posterior urethral valves', 'PUV']

entities_list: @entity11044 :: ('MESH:D014524', 'Disease') :: ['urethral obstruction']

answer: @entity340 :: (MESH:D006349,Disease) :: ['posterior urethral valves']


abstract: AIMS: Retention in @entity284 maintenance treatment (MMT) for 1year is associated with positive outcomes including opioid abstinence, however, most studies have not investigated gender differences. We hypothesized that predictors of retention and opioid abstinence would differ between @entity1 and @entity1 , and aimed to determine which factors best predict retention and abstinence for each gender. METHODS: Data were available for 290 @entity1 (173M, 117F) admitted to outpatient MMT. Regression analyses, stratified by gender, were conducted to identify unique predictors of MMT retention (<1 vs. >1year) and opioid abstinence rate (proportion of opioid-free urine samples up to 1year retention). RESULTS: Gender did not significantly predict treatment retention (mean=231days, 39% retained >1year) or opioid abstinence (49% overall). For males, significant predictors of >1-year retention were urine samples negative for opioids (odds ratio [OR]=6.67) and cannabinoids (OR=5.00) during the first month, and not @entity2072 dependent (OR=2.70). Significant predictors of higher long-term opioid abstinence were first-month urine samples negative for opioids and @entity2072 metabolites. For females, significant predictors of >1-year retention were first-month urine samples negative for @entity2072 metabolites (OR=4.00) and cannabinoids (OR=9.26), and no history of sexual victimization (OR=3.03). The only significant predictor of higher opioid abstinence rate was first-month opioid-free urine samples. CONCLUSIONS: These findings indicate gender-specific predictors of MMT retention and opioid abstinence. Future studies on MMT outcomes should examine each gender separately, and consider unique pathways by which females and males adhere to, and benefit from MMT.

title: Gender-specific predictors of retention and opioid abstinence during XXXX maintenance treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity284 :: ('MESH:D008691', 'Chemical') :: ['methadone']

answer: @entity284 :: (MESH:D008691,Chemical) :: ['methadone']


abstract: OBJECTIVE: To test if @entity4905 / @entity64 electronic decision support in primary care improves management. METHODS: Multicenter, single-blind, parallel-group, cluster randomized, controlled trial comparing @entity4905 / @entity64 electronic decision support guided management with usual care. Main outcomes were guideline adherence and 90-day @entity64 risk. Secondary outcomes were cerebrovascular/vascular/ @entity204 /adverse events, cost, and user feedback. Main analysis was logistic regression with a normal random effect for clusters using a generalized linear mixed model. RESULTS: Twenty-nine clinics were randomized to intervention, 27 to control, recruiting 172 and 119 eligible @entity1 . More intervention @entity1 received guideline-adherent care (131/172; 76.2%) than control @entity1 (49/119; 41.2%) (adjusted odds ratio [OR] 4.57; 95% confidence interval [CI] 2.39-8.71; p < 0.001). Ninety-day @entity64 occurred in 2/172 (1.2%) intervention and 5/119 (4.2%) control @entity1 (OR 0.27; 95% CI 0.05-1.41; p = 0.098). Ninety-day @entity4905 or @entity64 occurrence was lower in the intervention group, 4/172 (2.3%) compared to 10/119 (8.5%) control (adjusted OR 0.26; 95% CI 0.70-0.97; p = 0.045). Fewer vascular events/ @entity204 occurred in intervention, 6/172 (3.5%), than in control @entity1 , 14/119 (11.9%) (adjusted OR 0.27; 95% CI 0.09-0.78; p = 0.016). Treatment cost ratio of 0.65 (95% CI 0.47-0.91; p = 0.013) favored the intervention without increased adverse events. Clinician feedback was positive. CONCLUSION: Primary care use of the @entity4905 / @entity64 electronic decision support tool improves guideline adherence, safely reduces treatment cost, achieves positive user feedback, and may reduce cerebrovascular and vascular event risk following @entity4905 / @entity64 . CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that a primary care electronic decision support tool improves guideline adherence and might reduce 90-day @entity64 risk.

title: Cluster randomized controlled trial of XXXX electronic decision support in primary care.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

answer: @entity4905 :: (MESH:D002546,Disease) :: ['TIA']


abstract: BACKGROUND: Joint-preserving, realignment surgical procedures have gained increasing popularity as treatment of asymmetric early- and mid-stage @entity3681 . The aim of the present study was to quantify bilateral gait biomechanics in @entity1 who underwent ankle realignment surgery by supramalleolar osteotomies. METHODS: Eight @entity1 , a minimum of 7 years after realignment surgery, and 8 healthy controls were included in this study. Three-dimensional instrumented gait analysis was used to assess spatiotemporal parameters, bilateral joint angles, and moments. Furthermore, a clinical evaluation on @entity158 , ankle function, and quality of life was performed. RESULTS: Compared with the healthy controls, the @entity1 walked more slowly, had a smaller sagittal hindfoot range of motion on their affected leg, and had a lower peak ankle dorsiflexion moment (P < .05). There were no significant differences compared with controls for the ranges of motion in the foot segments of the nonaffected foot and for the knee and @entity572 and peak moments of both legs. Additionally, @entity1 and controls did not differ in the quality of life score. However, in the @entity158 subscore, the @entity1 reported significantly more @entity158 than the healthy @entity1 . CONCLUSION: Despite different gait biomechanics of the affected foot after ankle realignment surgery, the quality of life for @entity1 was comparable to that of healthy controls. Therefore, supramalleolar osteotomies should be considered as a promising treatment option in @entity1 with asymmetric non-end-stage @entity3681 . LEVEL OF EVIDENCE: Prognostic level III, comparative study.

title: Mid- to Long-term Clinical Outcome and Gait Biomechanics After Realignment Surgery in Asymmetric XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'persons']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['hip joint ranges of motion']

entities_list: @entity3681 :: ('MESH:D016512', 'Disease') :: ['ankle osteoarthritis']

answer: @entity3681 :: (MESH:D016512,Disease) :: ['Ankle Osteoarthritis']


abstract: AIM: Even though numerous studies have focused on the effects of self-stigma on @entity1 with @entity161 , little is known about self-stigma of @entity1 with @entity162 ( @entity162 ). In this study, a self-administered scale of self-stigmatising attitudes of @entity1 with @entity162 and @entity161 was used to explore these attitudes, examine the potential differences between the two groups and study the factors that influence stigma within groups. METHODS: Self-stigma of 120 @entity1 with @entity161 and @entity162 was assessed with the Self-stigma Questionnaire (SSQ) and the @entity1032 ( @entity1032 ). Presence of clinical symptoms, overall functioning and level of self-esteem were also evaluated. RESULTS: Self-stigma is present in both groups but differs in its intensity. @entity1 with @entity162 experience self-stigma in a lesser degree without affecting their social life or overall functioning. @entity1 with @entity161 adopt more intense self-stigmatising attitudes leading to social exclusion and lower level of overall functioning. LIMITATIONS: The results are limited by the small sample size, whereas the inclusion of other questionnaires would broaden our insight to self-stigma. CONCLUSIONS: Self-stigma has a direct effect on overall functioning of @entity1 with @entity162 and @entity161 tampering the clinical outcome of therapeutic interventions. Therefore, it should be incorporated in every treatment plan and be addressed as a clinical symptom of the @entity1032 .

title: XXXX and self-stigma: A comparison with @entity161 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'BD']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness', 'SIMI', 'Stigma Inventory for Mental Illness']

answer: @entity162 :: (MESH:D001714,Disease) :: ['Bipolar disorder']


abstract: AIM: Even though numerous studies have focused on the effects of self-stigma on @entity1 with @entity161 , little is known about self-stigma of @entity1 with @entity162 ( @entity162 ). In this study, a self-administered scale of self-stigmatising attitudes of @entity1 with @entity162 and @entity161 was used to explore these attitudes, examine the potential differences between the two groups and study the factors that influence stigma within groups. METHODS: Self-stigma of 120 @entity1 with @entity161 and @entity162 was assessed with the Self-stigma Questionnaire (SSQ) and the @entity1032 ( @entity1032 ). Presence of clinical symptoms, overall functioning and level of self-esteem were also evaluated. RESULTS: Self-stigma is present in both groups but differs in its intensity. @entity1 with @entity162 experience self-stigma in a lesser degree without affecting their social life or overall functioning. @entity1 with @entity161 adopt more intense self-stigmatising attitudes leading to social exclusion and lower level of overall functioning. LIMITATIONS: The results are limited by the small sample size, whereas the inclusion of other questionnaires would broaden our insight to self-stigma. CONCLUSIONS: Self-stigma has a direct effect on overall functioning of @entity1 with @entity162 and @entity161 tampering the clinical outcome of therapeutic interventions. Therefore, it should be incorporated in every treatment plan and be addressed as a clinical symptom of the @entity1032 .

title: @entity162 and self-stigma: A comparison with XXXX .

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: UNASSIGNED: The association between dialysis vascular @entity409 and the risk of developing major adverse cardiovascular events (MACE) in hemodialysis @entity1 is unclear and has not yet been investigated. We analyzed data from the National Health Insurance Research Database of Taiwan to quantify this association. Adopting a case-control design nested within a cohort of @entity1 who received hemodialysis from 2001 to 2010, we identified 9711 incident cases of MACE during the stage of stable maintenance dialysis and 19,422 randomly selected controls matched to cases on age, gender, and duration of dialysis. Events of vascular @entity409 in the 6-month period before the date of MACE onset (ie, index date) for cases and before index dates for controls were evaluated retrospectively. The presence of vascular @entity409 was associated with a 1.385-fold higher odds of developing MACE as estimated from the logistic regression analysis. This represents a significantly increased adjusted odds ratio (OR) at 1.268 (95% confidence interval [CI]=1.186-1.355) after adjustment for comorbidities and calendar years of initiating dialysis. We also noted a significant exposure-response trend (P<0.001) between the frequency of vascular @entity409 and MACE, with the greatest risk (adjusted OR=1.840, 95% CI=1.549-2.186) noted in @entity1 with >= 3 vascular access events. We concluded that dialysis vascular @entity409 was significantly associated with an increased risk of MACE. Hence, vascular access failure can be an early sign for MACE in @entity1 receiving maintenance hemodialysis. Active monitoring and treatment of cardiovascular risk factors and related diseases, not merely managing vascular @entity409 , would be required to reduce the risk of MACE.

title: Association Between Vascular Access Dysfunction and Subsequent Major Adverse Cardiovascular Events in XXXX on Hemodialysis: A Population-Based Nested Case-Control Study.

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['access dysfunction']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: The aim of this study was to determine the levels of @entity1243 ( @entity1243 ) and @entity1254 ( @entity1254 ) in @entity1 with @entity210 and its relationship with joint inflammatory data and/or with @entity209 ( @entity209 ) variables, during 1 year follow-up.Forty-one @entity1 (40 males) with @entity210 diagnosis, attending for the first time to a rheumatology department, were included. Evaluations were performed baseline, at 6 and 12 months. Variables included the following: demographic, clinical and laboratory data related to @entity210 and associated diseases. @entity1243 and @entity1254 determinations by the ELISA method were performed in frozen serum from each visit. The pharmacological and no-pharmacological treatment for @entity210 and associated diseases was individualized for each @entity1 according to published guidelines. Statistical analysis included Mann-Whitney U test, Fisher test, x, ANOVA, Cochran Q, Pearson and Spearman correlation tests, as well as linear regression.In the baseline evaluation, 29.2% had @entity209 ( @entity2298 66%, @entity101 44% and @entity28 37%); @entity1 with @entity209 had higher @entity1851 (CRP) levels [34.1  28.6 vs. 12.2  11.2mg/dL, P=0.033]. Although not significant, also had higher @entity1243 and lower @entity1254 levels (3.2  3.0 vs. 1.9  1.2ng/mL, P=0.142 and 40.5  26.8 vs. 38.0  24.9ng/mL, P=0.877, respectively). During follow-up, our @entity1 had significant improvement in serum @entity414 (sUA) levels and variables evaluating @entity158 (P  <= 0.05). @entity209 tended to persist or even worsen during the monitoring period: significant increase in total @entity165 (P=0.004), tendency to higher @entity1674 (P=0.883) and slight improvement in glycaemia (P=0.052). @entity1243 values increased significantly during follow-up (P=0.001) while @entity1254 levels diminished slightly (P=0.317). Neither @entity1243 nor @entity1254 values showed important correlation (r>0.5) with metabolic variables or joint swelling.This study suggests that in @entity1 with @entity210 , concentrations of @entity1243 and @entity1254 are more in line with the metabolic state than with clinical disease activity.

title: A Prospective Follow-Up of Adipocytokines in Cohort @entity1 With Gout: Association With XXXX But Not With Clinical Inflammatory Findings: Strobe-Compliant Article.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2298 :: ('MESH:D015228', 'Disease') :: ['hypertriglyceridemia']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1254 :: ('9370', 'Gene') :: ['AdipoQ', 'adiponectin']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain and joint swelling']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['Metabolic abnormalities', 'metabolic syndrome', 'MetS']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C reactive protein']

answer: @entity209 :: (MESH:D008659,Disease) :: ['Metabolic Syndrome']


abstract: UNASSIGNED: The aim of this study was to determine the levels of @entity1243 ( @entity1243 ) and @entity1254 ( @entity1254 ) in @entity1 with @entity210 and its relationship with joint inflammatory data and/or with @entity209 ( @entity209 ) variables, during 1 year follow-up.Forty-one @entity1 (40 males) with @entity210 diagnosis, attending for the first time to a rheumatology department, were included. Evaluations were performed baseline, at 6 and 12 months. Variables included the following: demographic, clinical and laboratory data related to @entity210 and associated diseases. @entity1243 and @entity1254 determinations by the ELISA method were performed in frozen serum from each visit. The pharmacological and no-pharmacological treatment for @entity210 and associated diseases was individualized for each @entity1 according to published guidelines. Statistical analysis included Mann-Whitney U test, Fisher test, x, ANOVA, Cochran Q, Pearson and Spearman correlation tests, as well as linear regression.In the baseline evaluation, 29.2% had @entity209 ( @entity2298 66%, @entity101 44% and @entity28 37%); @entity1 with @entity209 had higher @entity1851 (CRP) levels [34.1  28.6 vs. 12.2  11.2mg/dL, P=0.033]. Although not significant, also had higher @entity1243 and lower @entity1254 levels (3.2  3.0 vs. 1.9  1.2ng/mL, P=0.142 and 40.5  26.8 vs. 38.0  24.9ng/mL, P=0.877, respectively). During follow-up, our @entity1 had significant improvement in serum @entity414 (sUA) levels and variables evaluating @entity158 (P  <= 0.05). @entity209 tended to persist or even worsen during the monitoring period: significant increase in total @entity165 (P=0.004), tendency to higher @entity1674 (P=0.883) and slight improvement in glycaemia (P=0.052). @entity1243 values increased significantly during follow-up (P=0.001) while @entity1254 levels diminished slightly (P=0.317). Neither @entity1243 nor @entity1254 values showed important correlation (r>0.5) with metabolic variables or joint swelling.This study suggests that in @entity1 with @entity210 , concentrations of @entity1243 and @entity1254 are more in line with the metabolic state than with clinical disease activity.

title: A Prospective Follow-Up of Adipocytokines in Cohort XXXX With Gout: Association With @entity209 But Not With Clinical Inflammatory Findings: Strobe-Compliant Article.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: Female @entity2659 @entity19 were mated with @entity2659 X T/ + F1 males that were heterozygous for the @entity1619 lethal gene or were +/+. Fetuses from @entity2659 X +/+ matings were normal when observed on gestation Day 17 (plug day = Day 0). Those from the @entity2659 X T/+ cross exhibited the expected 1:1 ratio of short:normal tail lengths, but 10% of these fetuses were tailless, apparently due to factors in the @entity2659 genotype that increased the expressivity of the T-gene with regard to reduction of tail length. Additional @entity2659 females were mated with @entity2659 X tw18/+ F1 males. Fetuses from the @entity2659 X tw18/+ matings were normal. @entity2659 females carrying @entity2659 X +/+, @entity2659 X T/+, or @entity2659 X tw18/+ litters were injected ip on gestation Day 9 with 30 mg/kg @entity1880 or were untreated. @entity1880 was teratogenic for litters from all three crosses. Polydactyly, @entity56515 , and a variety of @entity853 were observed. Gross @entity600 were increased in treated @entity2659 X T/ + or tw18/+ litters in comparison with @entity2659 X +/+ litters, as were nonvertebral skeletal defects in @entity2659 X tw18/+ litters. Prenatal mortality was also greater in treated mutant-containing litters than in +/+ litters, and fetal weights were similarly decreased in treated @entity2659 X tw18/+ litters. The incidence of taillessness was also higher in treated (26%) than in control (10%) @entity2659 X T/+ litters. Thus both the T and tw18 alleles appear to have enhanced the teratogenicity of @entity1880 , and the inhibitor may have increased the expressivity of T.

title: Interactions between XXXX and T-locus alleles during @entity19 embryogenesis.

entities_list: @entity1619 :: ('MESH:D015458', 'Disease') :: ["brachyury (T') semidominant"]

entities_list: @entity1880 :: ('MESH:D003513', 'Chemical') :: ['cycloheximide', 'Cycloheximide']

entities_list: @entity853 :: ('MESH:D009139', 'Disease') :: ['skeletal abnormalities']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['malformations and total skeletal malformations']

entities_list: @entity56515 :: ('MESH:C535688', 'Disease') :: ['oligodactyly']

answer: @entity1880 :: (MESH:D003513,Chemical) :: ['cycloheximide']


abstract: Female @entity2659 @entity19 were mated with @entity2659 X T/ + F1 males that were heterozygous for the @entity1619 lethal gene or were +/+. Fetuses from @entity2659 X +/+ matings were normal when observed on gestation Day 17 (plug day = Day 0). Those from the @entity2659 X T/+ cross exhibited the expected 1:1 ratio of short:normal tail lengths, but 10% of these fetuses were tailless, apparently due to factors in the @entity2659 genotype that increased the expressivity of the T-gene with regard to reduction of tail length. Additional @entity2659 females were mated with @entity2659 X tw18/+ F1 males. Fetuses from the @entity2659 X tw18/+ matings were normal. @entity2659 females carrying @entity2659 X +/+, @entity2659 X T/+, or @entity2659 X tw18/+ litters were injected ip on gestation Day 9 with 30 mg/kg @entity1880 or were untreated. @entity1880 was teratogenic for litters from all three crosses. Polydactyly, @entity56515 , and a variety of @entity853 were observed. Gross @entity600 were increased in treated @entity2659 X T/ + or tw18/+ litters in comparison with @entity2659 X +/+ litters, as were nonvertebral skeletal defects in @entity2659 X tw18/+ litters. Prenatal mortality was also greater in treated mutant-containing litters than in +/+ litters, and fetal weights were similarly decreased in treated @entity2659 X tw18/+ litters. The incidence of taillessness was also higher in treated (26%) than in control (10%) @entity2659 X T/+ litters. Thus both the T and tw18 alleles appear to have enhanced the teratogenicity of @entity1880 , and the inhibitor may have increased the expressivity of T.

title: Interactions between @entity1880 and T-locus alleles during XXXX embryogenesis.

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: Background. Even if various pathophysiological events have been proposed as explanations, the putative cause of @entity2459 remains unclear. Objectives. To investigate and to reveal associations (if any) between the main iron-related gene variants and @entity1274 . Study Design. Case-control study. Materials and Methods. A total of 200 sudden @entity1274 @entity1 (median age 63.65 years; range 10-92) were compared with 400 healthy control subjects. The following genetic variants were investigated: the polymorphism c.-8CG in the promoter of the ferroportin gene ( @entity25341 ; @entity25341 ), the two isoforms @entity6350 ( @entity65483 ) of the @entity69 protein (TF), the amino acidic substitutions @entity14397 and @entity14399 in the @entity9595 protein ( @entity14398 ), and the polymorphism c.-582AG in the promoter of the @entity31392 gene, which encodes the protein hepcidin ( @entity31392 ). Results. The homozygous genotype c.-8GG of the @entity25341 gene revealed an OR for ISSNHL risk of 4.27 (CI 95%, 2.65-6.89; P = 0.001), being overrepresented among cases. Conclusions. Our study indicates that the homozygous genotype @entity25341 -8GG was significantly associated with increased risk of developing @entity2459 . These findings suggest new research should be conducted in the field of iron homeostasis in the inner ear.

title: Sudden XXXX and polymorphisms in iron homeostasis genes: new insights from a case-control study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['idiopathic sudden sensorineural hearing loss', 'sensorineural hearing loss']

entities_list: @entity14397 :: ('p|SUB|H|63|D', 'ProteinMutation') :: ['p.H63D']

entities_list: @entity9595 :: ('MESH:D006432', 'Disease') :: ['hereditary hemochromatosis']

entities_list: @entity2459 :: ('MESH:D003639', 'Disease') :: ['sudden hearing loss']

answer: @entity1274 :: (MESH:D006319,Disease) :: ['sensorineural hearing loss']


abstract: UNASSIGNED: Early excessive @entity1017 is positively associated with @entity28 , and yet the effect of @entity1017 during specific periods and the impact of @entity1 feeding practices are debated. The objective of the present study was to examine the impact of @entity1017 in periods of early childhood on body composition at 3 years, and whether @entity1 feeding modified the relationship between early growth and body composition at 3 years. We studied 233 @entity1 from the prospective cohort study, SKOT (in Danish: Sm  b  rns Kost og Trivsel). Birth weight z-scores (BWZ) and change in weight-for-age z-scores (WAZ) from 0 to 5, 5 to 9, 9 to 18 and 18 to 36 months were analysed for relations with body composition (anthropometry and bioelectrical impedance) at 3 years by multivariate regression analysis. BWZ and change in WAZ from 0 to 5 months were positively associated with BMI, fat mass index (FMI) and fat-free mass index (FFMI) at 3 years. Full breastfeeding for 6 months (compared to less than 1 month) eliminated the effect of early growth (P=  0  01). Full breastfeeding for 6 months (compared to less than 1 month) also eliminated the positive relation between BWZ and FMI (P=  0  009). No effect modification of @entity1 feeding was found for FFMI. In conclusion, high birth weight and rapid growth from 0 to 5 months were associated with increased FMI and FFMI at 3 years. Longer duration of full breastfeeding reduced the effect of birth weight and early @entity1017 on fat mass.

title: The impact of early growth patterns and XXXX feeding on body composition at 3 years of age.

entities_list: @entity1 :: ('9606', 'Species') :: ['infant', 'children']

entities_list: @entity1017 :: ('MESH:D015430', 'Disease') :: ['weight gain']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['later obesity']

answer: @entity1 :: (9606,Species) :: ['infant']


abstract: BACKGROUND: Prevention of secondary @entity1545 is a key component of acute management of @entity1 with severe @entity131 ( @entity131 ). Haemoglobin concentration may have an impact on optimization of cerebral oxygenation. @entity1 with @entity131 may best be served by an organized @entity130 service. The objective is to determine if haemoglobin concentration or dedicated @entity130 admission has an impact on outcomes after severe @entity131 . METHODS: This study retrospectively analysed consecutive @entity1 with severe @entity131 admitted to a level-I @entity130 centre over 3 years. @entity1 <16 years-old and with length of stay (LOS) <24 hours were excluded. Data were collected on demographics; injury severity; LOS; admission service; survival to discharge; and haemoglobin levels from hospital days 1-7. Data were also collected on number of transfusions of packed red blood cells. The sample was stratified based on admission service and survival to discharge. RESULTS: Of 147 @entity1 (age   =   54.1        3.7 years), overall mortality rate was 15.4% (n   =   23). Overall, non-survivors had lower daily and 7-day mean haemoglobin levels (10.7        0.9 vs. 12.9        0.4   g   dL(-1), p   <   0.001). Non-surgical admissions had lower haemoglobin levels and a higher mortality rate (28.9% vs. 12.2%, p   <   0.001) compared to dedicated @entity130 admissions. CONCLUSIONS: Among @entity1 with severe @entity131 , higher haemoglobin levels and maintenance as a dedicated @entity130 admission are associated with higher survival to discharge.

title: Higher haemoglobin levels and dedicated @entity130 admission are associated with survival after severe XXXX .

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']