abstract: A prospective cohort study of skeletally immature idiopathic scoliotic @entity1 treated with the TriaC brace. To determine if the TriaC brace is effective in preventing curve progression in immature adolescent idiopathic scoliotic @entity1 with a very high risk of curve progression based on reported natural history data. The aim of the newly introduced TriaC brace is to reverse the pathologic transverse force pattern by externally applied and continuously present orthotic forces. In the frontal plane the force system used in the TriaC brace is similar to the force system of the conventional braces. However, in the sagittal plane the force system acts only on the thoracic region. In addition, the brace allows upper @entity851 without affecting the corrective forces during body motion. In a preliminary study it is demonstrated that the brace prevents further progression of both the Cobb angle and @entity717 in @entity2112 . Skeletally immature @entity1 with @entity2112 with curves between 20 and 40 degrees were studied prospectively. Skeletally immature was defined as a Risser sign 0 or 1 for both @entity1 and @entity1 , or pre-menarche or less than 1-year post-menarche for @entity1 . Curves of less than 30 degrees had to have documented progression before entry. The mean age of the @entity1 at the start of treatment was 11.3 +/- 3.1 years. All measurements were collected by a single observer, and all @entity1 were followed up to skeletal maturity. Treatment was complete for all @entity1 when they had reached Risser sign 4 and did not show any further growth at length measurements. This was at a mean age of 15.6 +/- 1.1 years, with a mean follow-up of 1.6 years post bracing. In our study a successful outcome was obtained in 76% of @entity1 treated with the TriaC brace. Comparing our data to literature data on natural history of a similar cohort shows that the TriaC brace significantly alters the predicted natural history. The current study demonstrates that treatment with the TriaC brace reduces the scoliosis, and that the achieved correction is maintained in some degree after skeletal maturity is reached and bracing is discontinued. It also prevents further progression of the Cobb angle in @entity2112 . The new brace does not differ from the conventional braces as far as maintaining the deformity is concerned.

title: Clinical effect of continuous corrective force delivery in the non-operative treatment of XXXX : a prospective cohort study of the TriaC-brace.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'girls', 'boys']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['axial rotation']

entities_list: @entity2112 :: ('MESH:C564593', 'Disease') :: ['idiopathic scoliosis']

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['trunk flexibility']

answer: @entity2112 :: (MESH:C564593,Disease) :: ['idiopathic scoliosis']


abstract: Mediterranean diet is associated with lower incidence of @entity301 , and two randomised trials indicated that it improves prognosis of coronary @entity1 . These trials, however, relied on a total of 100 @entity204 and evaluated designer diets in the clinical context. We have evaluated the association of adherence to the modified Mediterranean diet, in which unsaturates were substituted for monounsaturates, with survival among elderly with previous @entity583 within the European Prospective Investigation into @entity5 and nutrition (EPIC) study. As of December 2003, after a median follow-up of 6.7 years, 2671 EPIC @entity1 from nine countries were 60 years or older and had prevalent @entity583 but no @entity64 or @entity5 at enrolment, complete information on dietary intakes and important covariates and known survival status. Adherence to the modified Mediterranean diet was assessed through a 10-unit-scale. Mortality ratio in relation to modified Mediterranean diet was estimated through @entity797 regression controlling for possible confounding. Increased adherence to modified Mediterranean diet by two units was associated with 18% lower overall mortality rate (95% confidence interval 7-27%, fixed effects model). There was no significant heterogeneity by sex, age at enrolment, or country, although the association tended to be less evident among northern Europeans. Associations between food groups contributing to the modified Mediterranean diet and mortality were generally weak. A diet inspired by the Mediterranean pattern that can be easily adopted by Western populations is associated with substantial reduction of total mortality of coronary @entity1 in the community.

title: Modified Mediterranean diet and survival after XXXX : the EPIC-Elderly study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'Cancer']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarction']


abstract: @entity17417 synthetase (AdSS) catalyzes the Mg2+ dependent condensation of a molecule of IMP with @entity492 to form adenylosuccinate, in a reaction driven by the hydrolysis of @entity3007 to @entity3006 . AdSS from the thermophilic archaea, @entity16684 (MjAdSS) is 345 @entity1522 long against an average length of 430-457 @entity1522 for most mesophilic AdSS. This short AdSS has two large deletions that map to the middle and C-terminus of the protein. This article discusses the detailed kinetic characterization of MjAdSS. Initial @entity28308 and product inhibition studies, carried out at 70 degrees C, suggest a rapid equilibrium random AB steady-state ordered C kinetic mechanism for the MjAdSS catalyzed reaction. AdSS are known to exhibit monomer-dimer equilibrium with the dimer being implicated in catalysis. In contrast, our studies show that MjAdSS is an equilibrium mixture of dimers and tetramers with the tetramer being the catalytically active form. The tetramer dissociates into dimers with a minor increase in ionic strength of the buffer, while the dimer is extremely stable and does not dissociate even at 1.2 M @entity1219 . @entity1391 , a product of the reaction, was found to be a potent inhibitor of MjAdSS showing biphasic inhibition of enzyme activity. The inhibition was competitive with IMP and noncompetitive with @entity3007 . MjAdSS, like the @entity19 acidic isozyme, exhibits substrate inhibition, with IMP inhibiting enzyme activity at subsaturating @entity3007 concentrations. Regulation of enzyme activity by the glycolytic intermediate, @entity4567 , was also observed with the inhibition being competitive with @entity15129 and noncompetitive against @entity3007 .

title: Kinetic characterization of XXXX synthetase from the thermophilic archaea @entity16684 .

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity16684 :: ('2190', 'Species') :: ['Methanocaldococcus jannaschii']

entities_list: @entity17417 :: ('MESH:C012168', 'Chemical') :: ['Adenylosuccinate']

entities_list: @entity4567 :: ('MESH:C029063', 'Chemical') :: ['fructose 1,6 bisphosphate']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['Phosphate']

entities_list: @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate']

answer: @entity17417 :: (MESH:C012168,Chemical) :: ['adenylosuccinate']


abstract: @entity17417 synthetase (AdSS) catalyzes the Mg2+ dependent condensation of a molecule of IMP with @entity492 to form adenylosuccinate, in a reaction driven by the hydrolysis of @entity3007 to @entity3006 . AdSS from the thermophilic archaea, @entity16684 (MjAdSS) is 345 @entity1522 long against an average length of 430-457 @entity1522 for most mesophilic AdSS. This short AdSS has two large deletions that map to the middle and C-terminus of the protein. This article discusses the detailed kinetic characterization of MjAdSS. Initial @entity28308 and product inhibition studies, carried out at 70 degrees C, suggest a rapid equilibrium random AB steady-state ordered C kinetic mechanism for the MjAdSS catalyzed reaction. AdSS are known to exhibit monomer-dimer equilibrium with the dimer being implicated in catalysis. In contrast, our studies show that MjAdSS is an equilibrium mixture of dimers and tetramers with the tetramer being the catalytically active form. The tetramer dissociates into dimers with a minor increase in ionic strength of the buffer, while the dimer is extremely stable and does not dissociate even at 1.2 M @entity1219 . @entity1391 , a product of the reaction, was found to be a potent inhibitor of MjAdSS showing biphasic inhibition of enzyme activity. The inhibition was competitive with IMP and noncompetitive with @entity3007 . MjAdSS, like the @entity19 acidic isozyme, exhibits substrate inhibition, with IMP inhibiting enzyme activity at subsaturating @entity3007 concentrations. Regulation of enzyme activity by the glycolytic intermediate, @entity4567 , was also observed with the inhibition being competitive with @entity15129 and noncompetitive against @entity3007 .

title: Kinetic characterization of @entity17417 synthetase from the thermophilic archaea XXXX .

answer: @entity16684 :: (2190,Species) :: ['Methanocaldococcus jannaschii']


abstract: BACKGROUND: @entity3929 aminotransferase (ALT) has been one of the most useful biomarkers reflecting @entity409 . Some studies have proposed that serum ALT levels, even those within the conventional normal range, are associated with @entity209 and @entity1560 . AIMS: We examined the correlation between ALT levels and @entity2690 resistance (IR) and ALT cutoff value for high IR status in Korean adolescents. METHODS: A total of 886 subjects (461 @entity1 and 425 @entity1 ) who participated in the 2009-2010 Korea National Health and Nutrition Examination Survey were included in this study. Multivariable adjusted logistic regression analyses were used to examine the odds ratios and 95  % confidence intervals (CIs) of the prevalence of the highest quartile of the homeostasis model assessment of IR (HOMA-IR) according to the ALT quartile. The cutoff value of ALT for the highest HOMA-IR quartile (Q4) were obtained using receiver operating characteristic curve analysis. RESULTS: The mean ALT value increased as the number of @entity209 components increased, but in only @entity1 (p for trend <0.001), while the IR quartile increased in both @entity1 and @entity1 (all p for trends <0.001). The prevalence of IR (Q4) was only increased in ALT (Q4) in @entity1 after the adjustment for age, body mass index, and waist circumference (OR 2.49; 95  % CI 1.05-5.91; p for trend  =  0.017). The cutoff values were 17.0  IU/L in @entity1 and 11.0  IU/L in @entity1 . CONCLUSIONS: The highest ALT quartile was associated with an increased prevalence of the highest quartile of IR in @entity1 but not in @entity1 .

title: Upper Normal XXXX Aminotransferase Range and @entity2690 Resistance in Korean Adolescents: Korean National Health and Nutrition Examination Survey, 2009-2010.

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty liver']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

answer: @entity3929 :: (D000409,Chemical) :: ['Alanine']


abstract: BACKGROUND: @entity3929 aminotransferase (ALT) has been one of the most useful biomarkers reflecting @entity409 . Some studies have proposed that serum ALT levels, even those within the conventional normal range, are associated with @entity209 and @entity1560 . AIMS: We examined the correlation between ALT levels and @entity2690 resistance (IR) and ALT cutoff value for high IR status in Korean adolescents. METHODS: A total of 886 subjects (461 @entity1 and 425 @entity1 ) who participated in the 2009-2010 Korea National Health and Nutrition Examination Survey were included in this study. Multivariable adjusted logistic regression analyses were used to examine the odds ratios and 95  % confidence intervals (CIs) of the prevalence of the highest quartile of the homeostasis model assessment of IR (HOMA-IR) according to the ALT quartile. The cutoff value of ALT for the highest HOMA-IR quartile (Q4) were obtained using receiver operating characteristic curve analysis. RESULTS: The mean ALT value increased as the number of @entity209 components increased, but in only @entity1 (p for trend <0.001), while the IR quartile increased in both @entity1 and @entity1 (all p for trends <0.001). The prevalence of IR (Q4) was only increased in ALT (Q4) in @entity1 after the adjustment for age, body mass index, and waist circumference (OR 2.49; 95  % CI 1.05-5.91; p for trend  =  0.017). The cutoff values were 17.0  IU/L in @entity1 and 11.0  IU/L in @entity1 . CONCLUSIONS: The highest ALT quartile was associated with an increased prevalence of the highest quartile of IR in @entity1 but not in @entity1 .

title: Upper Normal @entity3929 Aminotransferase Range and XXXX Resistance in Korean Adolescents: Korean National Health and Nutrition Examination Survey, 2009-2010.

answer: @entity2690 :: (3630,Gene) :: ['Insulin']


abstract: PURPOSE OF REVIEW: The present review discusses the etiology, clinical presentation, and management of femoroacetabular impingement (FAI) in the pediatric population, including etiologic and diagnostic controversies, management options, and outcomes. RECENT FINDINGS: New evidence demonstrates conflicting results regarding how and when primary FAI develops in relation to skeletal maturity. Recent studies also discuss the effects of sex, race, and sports on FAI development and radiographic considerations in the pediatric population. Recent literature demonstrates good to excellent outcomes in the operative management of FAI in @entity1 and adolescents. SUMMARY: FAI is a source of pediatric @entity158 and can occur primarily or secondarily. It is characterized by anterior @entity158 , made worse with flexion activities, decreased hip internal rotation, and a positive impingement sign. Pathologic values for radiographic measures of FAI are not clearly defined in the pediatric population. As FAI is a risk factor for @entity571 , early intervention in specific @entity1 may be indicated. Hip arthroscopy, surgical @entity572 , or combined mini-open and arthroscopic approaches are utilized, with good to excellent short, and mid-term functional results. Further study is required in the pediatric population to identify potential preventive strategies, to delineate the pathologic radiographic values of FAI, to define specific indications for operative management, and to examine long-term outcomes to determine optimal management.

title: Femoroacetabular impingement in XXXX and adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['hip dislocation']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: Although injection of hyaluronidase into surrounding tissues was proposed to treat arterial hyaluronic acid @entity887 , its application is still rather limited. The authors' goal was to investigate whether intravenous use of hyaluronidase can help resolve hyaluronic acid-induced @entity1416 . METHODS: Inferior epigastric arteries, nourishing inferior abdominal skin of @entity35 , were injected with 0.02 ml of hyaluronic acid to create the animal model. The @entity35 were divided randomly into four groups and given different solutions intravenously: hyaluronidase plus urokinase (group A), hyaluronidase (group B), urokinase (group C), or saline (group D). Progression of tissue @entity39 in all groups was recorded for 1 week. The flap survival rate and mean percentage of surviving flap area were analyzed. RESULTS: The animal model closely imitated actual hyaluronic acid arterial obstruction cases. Flap @entity39 occurrence rates of each group were 10 percent in group A, 70 percent in group B, 80 percent in group C, and 90 percent in group D. The mean surviving flap areas of each group were 92.45 percent (group A), 47.67 percent (group B), 41.41 percent (group C), and 33.19 percent (group D). When hyaluronidase and urokinase were used together, the flap @entity39 rate decreased significantly compared with that of the control group (p < 0.05). Even in cases of @entity39 , group A had a higher average surviving flap area than did the other groups. CONCLUSIONS: Combined use of hyaluronidase and urokinase can help increase the flap survival rate when administered intravenously in intraarterial hyaluronic acid occlusion cases. Both red @entity715 and hyaluronic acid emboli must be dissolved for flap reperfusion. This method shows a promising effect for future application.

title: Intravenous Hyaluronidase with Urokinase as Treatment for XXXX .

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['arterial embolism']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

answer: @entity1416 :: (MESH:D020762,Disease) :: ['Arterial Hyaluronic Acid Embolism']


abstract: BACKGROUND: @entity1781 is characterized by @entity1018 following facial @entity130 leading to variable @entity227 . The purpose of this study was to evaluate recent institutional trends in the treatment of @entity1781 , evaluate the outcomes of different treatment strategies, and identify factors associated with improved vision. METHODS: Institutional review board approval was obtained to retrospectively review @entity1 diagnosed with @entity1781 at a high-volume @entity130 center from 2004 to 2012. Pretreatment and posttreatment visual acuity was compared using quantitative analysis of standard ophthalmologic conversion. RESULTS: A total of 109 @entity1 met inclusion criteria (74.3 percent male @entity1 ), with a mean age of 38.0    17.5 years (range, 8 to 82 years). Management of @entity1781 involved intravenous @entity288 alone in 8.3 percent of @entity1 (n = 9), 56.9 percent (n = 62) underwent observation, 28.4 percent (n = 31) had surgical intervention, and 6.4 percent (n = 7) underwent surgery and corticosteroid administration. Only 19.3 percent of @entity1 returned for follow-up. Vision improved in 47.6 percent of @entity1 , with a mean follow-up of 12.9 weeks. @entity1 younger than 50 years had a trend toward higher rates of visual improvement, 60 percent versus 16.7 percent (p = 0.15). CONCLUSIONS: The majority of @entity1781 @entity1 are unlikely to return for a follow-up examination. Optic nerve decompression has fallen out of favor in the authors' institution, and observation is the most common management strategy. Outcomes following @entity228 administration and observation are comparable. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, IV.

title: Treatment Outcomes following XXXX .

entities_list: @entity1018 :: ('MESH:D054062', 'Disease') :: ['sudden loss of vision']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual deficits']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['Traumatic optic neuropathy', 'traumatic optic neuropathy']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity1781 :: (MESH:D009901,Disease) :: ['Traumatic Optic Neuropathy']


abstract: UNASSIGNED: Probiotics are a promising alternative to improve food animal productivity and health. However, scientific evidence that specific microbes can be used to benefit animal health and performance is limited. The objective of this study was to evaluate the effects of administering a live culture of Faecalibacterium prausnitzii to newborn dairy @entity291 on subsequent growth, health, and fecal microbiome. Initially, a safety trial was conducted using 30 newborn bull @entity291 to assess potential adverse effects of the oral and rectal administration of F. prausnitzii to neonatal @entity291 . No adverse reactions, such as increased body temperature or heart and respiratory rates, were observed after the administration of the treatments. All @entity291 survived the experimental period, and there was no difference in fecal consistency score, attitude, appetite or dehydration between the treatment groups. The rectal route was not an efficient practice while the oral route ensures that the full dose is administered to the treated @entity291 . Subsequently, a randomized field trial was completed in a commercial farm with preweaned @entity291 . A total of 554 Holstein heifers were assigned to one of two treatment groups: treated @entity291 (FPTRT) and non-treated @entity291 (control). Treated @entity291 received two oral doses of F. prausnitzii, one at treatment assignment (1st week) and another one week later. The FPTRT group presented significantly lower incidence of severe @entity294 (3.1%) compared with the control group (6.8%). Treated @entity291 also had lower mortality rate associated with severe @entity294 (1.5%) compared to control @entity291 (4.4%). Furthermore, FPTRT @entity291 gained significantly more weight, 4.4 kg over the preweaning period, than controls @entity291 . The relative abundance of F. prausnitzii in the fecal microbiota was significantly higher in the 3rd and 5th weeks of life of FPTRT @entity291 than of the control @entity291 , as revealed by sequencing of the 16S rRNA gene. Our findings showed that oral administration of F. prausnitzii improves @entity344 and growth of preweaned @entity291 , supporting its use as a potential probiotic.

title: Oral Administration of Faecalibacterium prausnitzii Decreased the Incidence of Severe XXXX and Related Mortality Rate and Increased Weight Gain in Preweaned Dairy Heifers.

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal health']

answer: @entity294 :: (MESH:D003967,Disease) :: ['Diarrhea']


abstract: BACKGROUND: Calcaneal quantitative ultrasound (QUS), which is used in the evaluation of @entity170 , is believed to be intimately associated with the characteristics of the proximal femur. However, the specific associations of calcaneal QUS with characteristics of the hip sub-regions remain unclear. DESIGN: A cross-sectional assessment of 53 @entity3604 @entity1 was performed for the skeletal status of the heel and hip. METHODS: We prospectively enrolled 53 female @entity3604 @entity1 with @entity3330 . Calcaneal QUS, dual energy X-ray absorptiometry (DXA), and hip structural analysis (HSA) were performed for each @entity1 . Femoral heads were obtained during the surgery, and principal compressive trabeculae (PCT) were extracted by a three-dimensional printing technique-assisted method. Pearson's correlation between QUS measurement with DXA, HSA-derived parameters and Young's modulus were calculated in order to evaluate the specific association of QUS with the parameters for the hip sub-regions, including the femoral neck, trochanteric and Ward's areas, and the femoral shaft, respectively. RESULTS: Significant correlations were found between estimated @entity1555 (Est. @entity1555 ) and @entity1555 of different sub-regions of proximal femur. However, the correlation coefficient of trochanteric area (r = 0.356, p = 0.009) was higher than that of the neck area (r = 0.297, p = 0.031) and total proximal femur (r = 0.291, p = 0.034). Furthermore, the quantitative ultrasound index (QUI) was significantly correlated with the HSA-derived parameters of the trochanteric area (r value: 0.315-0.356, all p<0.05) as well as with the Young's modulus of PCT from the femoral head (r = 0.589, p<0.001). CONCLUSION: The calcaneal bone had an intimate association with the trochanteric cancellous bone. To a certain extent, the parameters of the calcaneal QUS can reflect the characteristics of the trochanteric area of the proximal hip, although not specifically reflective of those of the femoral neck or shaft.

title: Correlation between Parameters of Calcaneal Quantitative Ultrasound and Hip Structural Analysis in XXXX @entity1 .

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity3330 :: ('MESH:D005264', 'Disease') :: ['femoral fractures']

answer: @entity3604 :: (MESH:D058866,Disease) :: ['Osteoporotic Fracture']


abstract: BACKGROUND: Calcaneal quantitative ultrasound (QUS), which is used in the evaluation of @entity170 , is believed to be intimately associated with the characteristics of the proximal femur. However, the specific associations of calcaneal QUS with characteristics of the hip sub-regions remain unclear. DESIGN: A cross-sectional assessment of 53 @entity3604 @entity1 was performed for the skeletal status of the heel and hip. METHODS: We prospectively enrolled 53 female @entity3604 @entity1 with @entity3330 . Calcaneal QUS, dual energy X-ray absorptiometry (DXA), and hip structural analysis (HSA) were performed for each @entity1 . Femoral heads were obtained during the surgery, and principal compressive trabeculae (PCT) were extracted by a three-dimensional printing technique-assisted method. Pearson's correlation between QUS measurement with DXA, HSA-derived parameters and Young's modulus were calculated in order to evaluate the specific association of QUS with the parameters for the hip sub-regions, including the femoral neck, trochanteric and Ward's areas, and the femoral shaft, respectively. RESULTS: Significant correlations were found between estimated @entity1555 (Est. @entity1555 ) and @entity1555 of different sub-regions of proximal femur. However, the correlation coefficient of trochanteric area (r = 0.356, p = 0.009) was higher than that of the neck area (r = 0.297, p = 0.031) and total proximal femur (r = 0.291, p = 0.034). Furthermore, the quantitative ultrasound index (QUI) was significantly correlated with the HSA-derived parameters of the trochanteric area (r value: 0.315-0.356, all p<0.05) as well as with the Young's modulus of PCT from the femoral head (r = 0.589, p<0.001). CONCLUSION: The calcaneal bone had an intimate association with the trochanteric cancellous bone. To a certain extent, the parameters of the calcaneal QUS can reflect the characteristics of the trochanteric area of the proximal hip, although not specifically reflective of those of the femoral neck or shaft.

title: Correlation between Parameters of Calcaneal Quantitative Ultrasound and Hip Structural Analysis in @entity3604 XXXX .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVE: To evaluate the role of an antiinflammatory lipid mediator, lipoxin A4 ( @entity20447 ), in @entity625 , we measured the level of @entity20447 in synovial fluid and lipoxin A4 receptor ( @entity53099 ) expression in synovial tissues obtained from @entity1 with @entity309 ( @entity309 ) and @entity571 ( @entity571 ). METHODS: Levels of @entity20447 and its analog ( @entity20447 ) in synovial fluid from 30 @entity1 with @entity309 and 15 @entity1 with @entity571 were measured by a specific ELISA. Reverse transcription-polymerase chain reaction (RT-PCR), real-time quantitative PCR, and in situ hybridization were performed to detect mRNA for @entity53099 and @entity13695 , and @entity20447 synthetase, in synovial tissues from 20 @entity1 with @entity309 and 10 @entity1 with @entity571 . RESULTS Both @entity20447 and @entity20447 showed significantly higher levels in @entity309 synovial fluid (10.34 +/- 14.12 ng/ml for @entity20447 ) than @entity571 synovial fluid (0.66 +/- 0.77 ng/ml for @entity20447 ). Logarithmic concentration of @entity20447 was significantly correlated with that of leukotriene B4 and @entity1421 in @entity309 and @entity571 synovial fluids. Expressions of @entity53099 and @entity13695 mRNA were stronger in @entity309 synovium than @entity571 synovium. Expression of mRNA for @entity4047 ( @entity4047 ), which induces @entity13695 , was significantly stronger in @entity309 synovium than @entity571 synovium. CONCLUSION: @entity53099 is an important target of @entity20447 in synovial tissues of @entity1 with @entity309 . @entity13695 induced by @entity4047 might regulate the production of @entity20447 to have an antiinflammatory effect against proinflammatory lipid mediators in inflamed joints. These findings could lead to the development of new therapy for @entity625 such as @entity309 .

title: Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['inflammatory arthritis']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'osteoarthritis']

entities_list: @entity1421 :: ('MESH:D015232', 'Chemical') :: ['prostaglandin E2']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: OBJECTIVE: To evaluate the role of an antiinflammatory lipid mediator, lipoxin A4 ( @entity20447 ), in @entity625 , we measured the level of @entity20447 in synovial fluid and lipoxin A4 receptor ( @entity53099 ) expression in synovial tissues obtained from @entity1 with @entity309 ( @entity309 ) and @entity571 ( @entity571 ). METHODS: Levels of @entity20447 and its analog ( @entity20447 ) in synovial fluid from 30 @entity1 with @entity309 and 15 @entity1 with @entity571 were measured by a specific ELISA. Reverse transcription-polymerase chain reaction (RT-PCR), real-time quantitative PCR, and in situ hybridization were performed to detect mRNA for @entity53099 and @entity13695 , and @entity20447 synthetase, in synovial tissues from 20 @entity1 with @entity309 and 10 @entity1 with @entity571 . RESULTS Both @entity20447 and @entity20447 showed significantly higher levels in @entity309 synovial fluid (10.34 +/- 14.12 ng/ml for @entity20447 ) than @entity571 synovial fluid (0.66 +/- 0.77 ng/ml for @entity20447 ). Logarithmic concentration of @entity20447 was significantly correlated with that of leukotriene B4 and @entity1421 in @entity309 and @entity571 synovial fluids. Expressions of @entity53099 and @entity13695 mRNA were stronger in @entity309 synovium than @entity571 synovium. Expression of mRNA for @entity4047 ( @entity4047 ), which induces @entity13695 , was significantly stronger in @entity309 synovium than @entity571 synovium. CONCLUSION: @entity53099 is an important target of @entity20447 in synovial tissues of @entity1 with @entity309 . @entity13695 induced by @entity4047 might regulate the production of @entity20447 to have an antiinflammatory effect against proinflammatory lipid mediators in inflamed joints. These findings could lead to the development of new therapy for @entity625 such as @entity309 .

title: Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of XXXX with @entity309 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: In @entity1 with longstanding severe @entity309 ( @entity309 ) receiving chronic treatment with adalimumab, health related quality of life (HRQOL) was assessed using new instruments [Functional Assessment of @entity102 Therapy-Fatigue scale (FACIT-Fatigue) and Health Utilities Index @entity26077 (HUI3)] and a more conventional instrument [Medical Outcomes Study Short Form-36 Health Survey (SF-36)]. METHODS: Different measures for collecting @entity1 -reported outcomes were applied simultaneously during the 3-year study period. Sociodemographic and medical history data were assessed at the baseline visit. Clinical examinations (e.g., joint examination and morning stiffness), disease assessments, and HRQOL data were recorded every 8 weeks. For dichotomous and categorical variables, absolute and relative frequencies were calculated. Metric measures were described using mean and standard deviation and/or standard error of the mean. HRQOL data were analyzed using observed cases. RESULTS: All assessed measures (FACIT-Fatigue, HUI3, SF-36) showed a rapid and statistically significant improvement from baseline following initiation of adalimumab therapy. This effect was maintained over the study period for a mean of 1.6 years in all applied measures. HRQOL data from all tested instruments were significantly correlated with each other. CONCLUSION: Chronic therapy with adalimumab improved measures of fatigue and HRQOL in @entity1 with longstanding @entity309 .

title: Improvement and longterm maintenance of quality of life during treatment with adalimumab in severe XXXX .

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic Illness']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: PURPOSE: The treatment and outcome of primary @entity1893 ( @entity1893 ) has rarely been described. This retrospective study documents the clinicopathologic features and treatment results in this relatively rare entity. @entity1 AND METHODS: This study was conducted on 11 @entity1 diagnosed and treated for primary @entity1893 over a period of 22 years. RESULTS: Of the 4 male and 7 female @entity1 , only one presented with the classic pattern of Sj  @entity244 ( @entity244 ) simultaneous with @entity1893 , and only 4 @entity1 demonstrated a low-grade Maltoma type. None of the @entity1 had evidence of disease at the end of the primary treatment; 4 @entity1 are alive and well from 6 months to 10 years after the end of treatment. Four @entity1 relapsed and died due to therapy-resistant disease and 3 @entity1 died of nonmalignant causes while in complete remission. CONCLUSION: The majority of @entity1 with primary @entity1893 present with early- stage disease. Accurate staging is mandatory. Low-grade, localized @entity1893 can be treated successfully with primary radiotherapy alone. The aggressive type of @entity1893 should be treated with combined chemoradiotherapy-based regimens.

title: Diagnosis and treatment of primary XXXX of the parotid gland: a retrospective study - Experience at the Northern Israel Oncology Center (1977-1999).

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non- Hodgkin's lymphoma of the parotid gland", "parotid gland non-Hodgkin's lymphoma", 'PGL']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity244 :: ('MESH:D014899', 'Disease') :: ["gren's syndrome", 'SS']

answer: @entity1893 :: (MESH:D008228,Disease) :: ['non-Hodgkin's lymphoma']


abstract: PURPOSE: To evaluate the prevalence of dual platelet inhibition in cases of severe @entity548 following retrobulbar and peribulbar anesthesia. SETTING: Department of Ophthalmology, Ludwig-Maximilans Universit  t, M  nchen, Germany. DESIGN: Retrospective study. METHODS: Two groups of @entity1 were screened retrospectively over a 5-year period for the inclusion criterion of severe @entity1410 after retrobulbar or parabulbar injection. The first group consisted of emergency cases referred to the clinic. A second group of @entity1 had received retrobulbar block at the hospital. All cases were collected and screened for the presence of antiplatelet therapy. RESULTS: Among roughly 160   000 @entity1 records screened, 3 @entity1 with grade @entity1410 were identified. Two of these @entity1 were taking dual antiplatelet medications and 2 were on anticoagulation therapy during the time of retrobulbar or peribulbar anesthesia. None of the cases showed single medication platelet inhibition. The visual acuity of all @entity1 stayed low at the 6-month follow-up (1.2 logMAR in 1 @entity1 and no light perception in 2 @entity1 ). CONCLUSIONS: Retrobulbar @entity1410 is a rare but severe complication of retrobulbar anesthesia. With the high prevalence of dual platelet inhibition found in these cases, a prospective controlled trial seems unethical. In these high-risk @entity1 , surgery should be performed under topical anesthesia if possible or general anesthesia if necessary. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Dual platelet inhibition in cases of severe XXXX following retrobulbar and peribulbar anesthesia.

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['IV retrobulbar hematoma', 'hematoma', 'retrobulbar hematoma']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['retrobulbar hemorrhage']

answer: @entity548 :: (MESH:D006470,Disease) :: ['retrobulbar hemorrhage']


abstract: PURPOSE: To evaluate @entity1 safety and refractive outcomes in eyes with an angle-supported phakic intraocular lens (pIOL), and to assess the correlation between rotation and corneal endothelial cell damage. SETTING: Gimbel Eye Centres, Calgary and Edmonton, Alberta, Canada. DESIGN: Retrospective cohort study. METHODS: This study included @entity1 with moderate to high @entity1714 (range -6.50 to -19.50 diopters [D]) who received the Acrysof Cachet pIOL. Outcome measures included uncorrected distance visual acuity (UDVA), corrected distance visual acuity, manifest refraction spherical equivalent (MRSE), @entity1358 ( @entity1358 ), and @entity717 . RESULTS: This study evaluated 119 eyes of 61 @entity1 . The mean @entity1358 decrease from preoperative measurements was 3.11% (n = 46), with a mean @entity717 of 10.6 degrees (n = 35) at the 3-year postoperative visit. Of the 49 eyes at the 3-year visit measured for UDVA, 98.0% were 20/40 or better and 77.6% were 20/20 or better. The MRSE improved from a preoperative mean of -9.26 diopters (D)    2.43 (SD) (range -19.50 to -5.63 D) to -0.33    0.61 D (range -3.12 to +0.71 D) at the 3-year visit. The residual refractive error was within   0.50 D of the target refraction for 78.4% and within   1.00 D for 92.2% of the 51 eyes. The study included one bilateral pIOL removal due to endothelial cell loss, one case of @entity5862 , and one case of @entity2300 . CONCLUSIONS: No correlation between @entity717 and @entity1358 decrease was found (R(2) = 0.0143); the pIOL provided promising refractive outcomes and acceptable safety in @entity1 with moderate to high @entity1714 . FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Angle-supported phakic intraocular lenses for the correction of XXXX : Three-year follow-up.

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['endothelial cell density', 'ECD']

entities_list: @entity2300 :: ('MESH:D011681', 'Disease') :: ['subtle pupil ovalization']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['IOL rotation']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['myopia']


abstract: OBJECTIVE: Pain assessment of individuals with @entity72 ( @entity72 ) is largely unexplored. The core deficits of @entity72 may interfere with this population's ability to effectively use traditional @entity158 assessment tools. Accurate @entity158 assessment is essential to providing quality care. The objective was to illuminate barriers to @entity158 assessment in @entity1 with an @entity72 , describe novel methods to communicate about their @entity158 experience, and identify vocabularies that hold meaning with respect to @entity158 to better understand @entity158 from their context. METHODS: Qualitative descriptive study using semistructured interviews including interactive electronic technology to enhance communication. Subjects included @entity1 aged 6 to 17 years with @entity72 experiencing @entity12761 after a surgical procedure at a large urban tertiary @entity1 's hospital. RESULTS: Based on the analysis of 40 interviews, @entity1 consisted of 34 (85%) male, 29 (72.5%) non-Hispanic white with mean age 11.75    3.36 years (range: 6-17). All subjects were able to describe and locate their @entity158 but required a variety of approaches. Assessment preferences included minimal time spent focusing on @entity158 and simplistic language and actions using terms familiar to each subject. Notably, subjects were able to reliably demonstrate understanding of graded response and seriation. Parent involvement was essential, both in helping interpret the @entity1 's needs and providing trusted support. CONCLUSIONS: Some @entity1 with @entity72 require an alternate interactive approach to @entity158 assessment. Individualized consideration and estimation of @entity158 assessment methods for use in this population may provide more meaningful interactions, ultimately guiding better @entity158 management interventions.

title: Pain Assessment of @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'child']

entities_list: @entity72 :: ('MESH:D002659', 'Disease') :: ['ASD', 'autism spectrum disorder']

answer: @entity72 :: (MESH:D002659,Disease) :: ['Autism Spectrum Disorders']


abstract: OBJECTIVE: Pain assessment of individuals with @entity72 ( @entity72 ) is largely unexplored. The core deficits of @entity72 may interfere with this population's ability to effectively use traditional @entity158 assessment tools. Accurate @entity158 assessment is essential to providing quality care. The objective was to illuminate barriers to @entity158 assessment in @entity1 with an @entity72 , describe novel methods to communicate about their @entity158 experience, and identify vocabularies that hold meaning with respect to @entity158 to better understand @entity158 from their context. METHODS: Qualitative descriptive study using semistructured interviews including interactive electronic technology to enhance communication. Subjects included @entity1 aged 6 to 17 years with @entity72 experiencing @entity12761 after a surgical procedure at a large urban tertiary @entity1 's hospital. RESULTS: Based on the analysis of 40 interviews, @entity1 consisted of 34 (85%) male, 29 (72.5%) non-Hispanic white with mean age 11.75    3.36 years (range: 6-17). All subjects were able to describe and locate their @entity158 but required a variety of approaches. Assessment preferences included minimal time spent focusing on @entity158 and simplistic language and actions using terms familiar to each subject. Notably, subjects were able to reliably demonstrate understanding of graded response and seriation. Parent involvement was essential, both in helping interpret the @entity1 's needs and providing trusted support. CONCLUSIONS: Some @entity1 with @entity72 require an alternate interactive approach to @entity158 assessment. Individualized consideration and estimation of @entity158 assessment methods for use in this population may provide more meaningful interactions, ultimately guiding better @entity158 management interventions.

title: Pain Assessment of XXXX with @entity72 .

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: BACKGROUND: Previous studies revealed that among @entity1 with normal and high body mass index (BMI), @entity209 contribute to the increased risk of @entity65 ( @entity65 ). However, studies investigating the metabolic features and its association with @entity65 are limited. METHODS: A national representative sample of adult population in China was used. Underweight was defined as BMI <18.5kg/m(2). @entity1 who had less than 2 criteria of @entity209 were classified as metabolically healthy; those who had 2 or more criteria of @entity209 were classified as metabolically abnormal. Presence of @entity65 and @entity633 were compared among groups stratified by BMI and metabolic status. RESULTS: Among 46308 @entity1 , 2267 (4.6%) were classified as underweight; and 372 (16.4%) of them were identified as metabolically abnormal. Metabolic features were comparable between underweight but metabolically abnormal @entity1 and @entity28 @entity1 . Compared with @entity1 with normal weight and normal metabolic features, the underweight but metabolically abnormal @entity1 were more likely to have @entity65 and @entity633 , with an adjusted odds ratio of 2.33 (95% confidence interval (CI) 1.34-4.05) and 2.56 (95% CI 1.86-3.52), respectively. Among underweight @entity1 , factors associated with metabolic abnormal phenotype included leisure time physical inactivity, mild occupational physical activity, and waist circumference. CONCLUSIONS: Metabolically abnormal phenotype is not rare among underweight population in China, and preventive strategy against @entity65 should also be considered in that population.

title: Underweight but metabolically abnormal phenotype: Metabolic features and its association with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'people']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome', 'metabolic abnormalities']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']


abstract: BACKGROUND: @entity6703 ( @entity6703 ) is a major cause of direct maternal mortality in Australia and New Zealand. There has been no national population study of @entity6703 in either country. The aim of this study was to estimate the incidence of @entity6703 in Australia and New Zealand and to describe risk factors, management, and perinatal outcomes. METHODS: A population-based descriptive study using the Australasian Maternity Outcomes Surveillance System (AMOSS) carried out in 263 eligible sites (>50 births per year) covering an estimated 96  % of @entity1 giving birth in Australia and all 24 New Zealand maternity units (100  % of @entity1 giving birth in hospitals) between January 1 2010-December 31 2011. A case of @entity6703 was defined either as a clinical diagnosis (acute @entity551 or @entity1167 , acute @entity519 and @entity1003 in the absence of any other potential explanation for the symptoms and signs observed) or as a post mortem diagnosis (presence of fetal squames/debris in the pulmonary circulation). RESULTS: Thirty-three cases of @entity6703 were reported from an estimated cohort of 613,731 @entity1 giving birth, with an estimated incidence of 5.4 cases per 100   000 @entity1 giving birth (95  % CI 3.5 to 7.2 per 100   000). Two (6  %) events occurred at home whilst 46  % (n   =   15) occurred in the birth suite and 46  % (n   =   15) in the operating theatre (location not reported in one case). Fourteen @entity1 (42  %) underwent either an induction or augmentation of labour and 22 (67  %) underwent a caesarean section. Eight @entity1 (24  %) conceived using assisted reproduction technology. Thirteen (42  %) @entity1 required cardiopulmonary resuscitation, 18  % (n   =   6) had a hysterectomy and 85  % (n   =   28) received a transfusion of blood or blood products. Twenty (61  %) were admitted to an Intensive Care Unit (ICU), eight (24  %) were admitted to a High Dependency Unit (HDU) and seven (21  %) were transferred to another hospital for further management. Five @entity1 died (case fatality rate 15  %) giving an estimated maternal mortality rate due to @entity6703 of 0.8 per 100   000 @entity1 giving birth (95  % CI 0.1  % to 1.5  %). There were two deaths among 36 @entity1 . CONCLUSIONS: A coordinated emergency response requiring resource intense multi-disciplinary input is required in the management of @entity1 with @entity6703 . Although the case fatality rate is lower than in previously published studies, high rates of hysterectomy, resuscitation, and admission to higher care settings reflect the significant morbidity associated with @entity6703 . Active, ongoing surveillance to document the risk factors and short and long-term outcomes of @entity1 and their babies following @entity6703 may be helpful to guide best practice, management, counselling and service planning. A potential link between @entity6703 and assisted reproductive technology warrants further investigation.

title: XXXX : an Australian-New Zealand population-based study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'infants']

entities_list: @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathy']

entities_list: @entity6703 :: ('MESH:D004619', 'Disease') :: ['Amniotic fluid embolism', 'amniotic fluid embolism', 'AFE']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

answer: @entity6703 :: (MESH:D004619,Disease) :: ['Amniotic fluid embolism']


abstract: PURPOSE: To report long-term results of Artisan phakic intraocular lens (pIOL) to correct @entity1714 and to propose a model predicting endothelial cell loss after pIOL implantation. SETTING: Quinze-Vingts National Ophthalmology Hospital, Paris, France. DESIGN: Retrospective, interventional case series. METHODS: Uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and central endothelial cell count (ECC) were determined before and at yearly intervals up to 5 years after pIOL implantation. Linear model analysis was performed to present a model that describes endothelial cell loss as a linear decrease and an additional decrease depending on postoperative loss. RESULTS: A total of 49 @entity1 (68 eyes) implanted with pIOLs from January 2000 to January 2009 were evaluated. The mean preoperative and final spherical equivalent (SE) were -13    4.10 and -0.75    0.74 diopters (D), respectively. The mean preoperative and final central ECC were 2629    366 and 2250    454 cells/mm(2), respectively. There were no intraoperative complications for any of the eyes. One eye required surgery for repositioning the pIOL, and 1 eye required pIOL exchange for postoperative @entity2516 . The model predicted that for @entity1 with preoperative ECC of 3000, 2500, and 2000 cells/mm(2), a critical ECC of 1500 cells/mm(2) will be reached at 39, 28, and 15 years after implantation, respectively. CONCLUSIONS: Implantation of the pIOL was an effective and stable procedure after 5 years of follow-up. The presented model predicted @entity393 after pIOL implantation, which can assist ophthalmologists in @entity1 selection and follow-up. FINANCIAL DISCLOSURE: The authors report no conflict of interest.

title: Iris-fixated phakic intraocular lens implantation to correct XXXX and a predictive model of endothelial cell loss.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive error']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['myopia']


abstract: OBJECTIVE: To examine the effect of @entity1875 dosing (total dose and number of doses) on @entity1 sedation time and likelihood of resedation. METHODS: This was a prospective, observational @entity1 series in an urban district hospital @entity2613 with 42 000 attendances per annum. @entity1 undergoing an emergent procedure requiring procedural sedation were included. Titrated intravenous @entity1875 was administered according to departmental procedure. Standardized consent and data collection forms were used. Time taken for the @entity1 to become conversational after first administration was recorded and any resedation documented. RESULTS: Four hundred @entity1 , undergoing 404 procedures, were enrolled for the period commencing August 2004 until March 2006. The mean initial @entity1875 bolus was 0.8 mg/kg (SD 0.6), and mean total @entity1875 dose was 1.8 mg/kg (SD 1.0), comprising a mean of 2.3 (SD 2.1) doses of 15.8 mg (SD 11.4). Mean sedation time was 11.8 min (SD 6.9), and increased sedation times were associated with higher total @entity1875 dose and number of boluses (P < 0.0001). Resedation occurred in two @entity1 (0.5%, 95% CI 0-1.6%). CONCLUSION: Shorter sedation times are seen with lower doses of @entity1875 . @entity1 do not need prolonged post-procedure monitoring because the occurrence of spontaneous resedation associated with @entity1875 use is a rare event. This has implications for @entity1 flow and staff resource allocation in a busy @entity2613 .

title: Optimization of XXXX dose shortens procedural sedation time, prevents resedation and removes the requirement for post-procedure physiologic monitoring.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

answer: @entity1875 :: (MESH:D015742,Chemical) :: ['propofol']


abstract: The aim of this study was to provide data on the prognosis and treatment options of @entity10 associated with sexual activity (HSA). Sixty @entity1 diagnosed with HSA between 1996 and 2004 were followed up between 2003 and 2006 at least 12 months after the first interview. The further course of the disease and their contentedness with therapy were requested. On average, the second interview was performed 35.9 months after the first examination. Of the 45 @entity1 who had suffered from single attacks or bouts prior to baseline examination, 37 had no further attacks. Seven @entity1 suffered from at least one further bout with an average duration of 2.1 months. One @entity1 developed a chronic course of the disease after an episodic start. Of the 15 @entity1 with @entity102 at the first examination, seven were in remission and five had ongoing attacks at follow-up. Ten @entity1 received @entity3352 for preemptive therapy, with good results in nine @entity1 . Eighteen @entity1 received beta-blockers for prophylaxis, with good results in 15 @entity1 . Episodic HSA occurs in approximately three-quarters and chronic HSA in approximately one-quarter of @entity1 . Even in chronic HAS, the prognosis is favourable, with remission rates of 69% during an observation period of 3 years. For @entity1 with longer-lasting bouts or with chronic HSA, prophylactic treatment with beta-blockers or preemptive therapy with @entity3352 are often successful.

title: XXXX associated with sexual activity: prognosis and treatment options.

entities_list: @entity3352 :: ('MESH:D007213', 'Chemical') :: ['indomethacin']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

answer: @entity10 :: (MESH:D006261,Disease) :: ['Headache']


abstract: OBJECTIVE: To analyze the individual and combined diagnostic yield and clinical utility of transbronchial needle aspiration and transbronchial biopsy in the histologic diagnosis of @entity370 in stages I and II. @entity1 AND METHODS: We performed a prospective study enrolling all the @entity1 admitted to our hospital between July 2001 and June 2006 with mediastinal lymph nodes of a diameter of over 10 mm and clinical and radiological indication of @entity370 . The @entity1 underwent the following tests in the order specified: a transbronchial needle aspiration of 1 or more lymph nodes using a 19-gauge histology needle until 2 satisfactory specimens were obtained, a bronchoalveolar lavage, and 4 to 6 transbronchial biopsies. RESULTS: A total of 32 @entity1 were enrolled during the study period. Of these, 26 were finally diagnosed with @entity370 . The mean (SD) age of the @entity1 was 38.9 (10.6) years and there were 13 @entity1 (50%). The mean (SD) lymph node diameter was 23.5 (6.5) mm. The most common lymph node aspiration sites were the subcarinal station (9 @entity1 , 34.6%) and a combination of the subcarinal and paratracheal stations (7 @entity1 , 26.9%). Computed tomography scans of the chest revealed parenchymal involvement in 12 (46.2%) @entity1 . Fifteen (57.7%) @entity1 were diagnosed by transbronchial biopsy and 16 (61.5%) by transbronchial needle aspiration. These techniques were used in isolation in 7 (26.9%) and 8 (30.8%) @entity1 , respectively (P>.05). Diagnosis was achieved with the combined results of transbronchial biopsy and needle aspiration in 23 (88.4%) @entity1 . Overall, the diagnostic yield of the combined techniques was significantly higher than that of either one in isolation (P=.01 vs transbronchial biopsy and P=.02 vs needle aspiration). In @entity1 with parenchymal involvement, yield was better for the combined techniques only in comparison with transbronchial biopsy (P=.01). Only 4 (15%) @entity1 developed complications and 20 (76.9%) tolerated the procedures well. CONCLUSIONS: Diagnostic yield was significantly higher when transbronchial biopsy and transbronchial needle aspiration were used in combination than when used alone, particularly in @entity1 without parenchymal involvement. There were few complications and tolerance was good.

title: [Clinical utility of transbronchial needle aspiration of mediastinal lymph nodes in the diagnosis of XXXX in stages I and II].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women', 'PATIENTS']

entities_list: @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis']

answer: @entity370 :: (MESH:D012507,Disease) :: ['sarcoidosis']


abstract: BACKGROUND: Gene expression profiling of @entity5 is a successful tool for the discovery of new @entity5 biomarkers and potential targets for the development of new therapeutic strategies. Reliable profiling is preferably performed on fresh frozen (FF) tissues in which the quality of nucleic acids is better preserved than in @entity406 -fixed @entity982 -embedded (FFPE) material. However, since snap-freezing of biopsy materials is often not part of daily routine in pathology laboratories, one may have to rely on archival FFPE material. Procedures to retrieve the RNAs from FFPE materials have been developed and therefore, datasets obtained from FFPE and FF materials need to be made compatible to ensure reliable comparisons are possible. AIM: To develop an efficient method to compare gene expression profiles obtained from FFPE and FF samples using the same platform. METHODS: Twenty-six FFPE-FF sample pairs of the same @entity5 representing various @entity5 types, and two FFPE-FF sample pairs of @entity0 cell lines, were included. Total RNA was extracted and gene expression profiling was carried out using Illumina's Whole-Genome cDNA-mediated Annealing, Selection, extension and Ligation (WG-DASL) V3 arrays, enabling the simultaneous detection of 24,526 mRNA transcripts. A sample exclusion criterion was created based on the expression of 11 stably expressed reference genes. Pearson correlation at the probe level was calculated for paired FFPE-FF, and three cut-off values were chosen. Spearman correlation coefficients between the matched FFPE and FF samples were calculated for three probe lists with varying levels of significance and compared to the correlation based on all measured probes. Unsupervised hierarchical cluster analysis was performed to verify performance of the included probe lists to compare matched FPPE-FF samples. RESULTS: Twenty-seven FFPE-FF pairs passed the sample exclusion criterion. From the profiles of 27 FFPE and FF matched samples, the best correlating probes were identified for various levels of significance (Pearson P<0.01, n = 1,432; P<0.05, n = 2,530; and P<0.10, n = 3,351 probes). Unsupervised hierarchical clustering of the 27 pairs using the resulting probes yielded 25, 21, and 19 correctly clustered pairs, respectively, compared to 1 pair when all probes were used. CONCLUSION: The proposed method enables comparison of gene expression profiles of FFPE and/or FF origin measured on the same platform.

title: A Method to Correlate mRNA Expression Datasets Obtained from Fresh Frozen and @entity406 -Fixed, XXXX -Embedded Tissue Samples: A Matter of Thresholds.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity982 :: (MESH:D010232,Chemical) :: ['Paraffin']


abstract: BACKGROUND: Gene expression profiling of @entity5 is a successful tool for the discovery of new @entity5 biomarkers and potential targets for the development of new therapeutic strategies. Reliable profiling is preferably performed on fresh frozen (FF) tissues in which the quality of nucleic acids is better preserved than in @entity406 -fixed @entity982 -embedded (FFPE) material. However, since snap-freezing of biopsy materials is often not part of daily routine in pathology laboratories, one may have to rely on archival FFPE material. Procedures to retrieve the RNAs from FFPE materials have been developed and therefore, datasets obtained from FFPE and FF materials need to be made compatible to ensure reliable comparisons are possible. AIM: To develop an efficient method to compare gene expression profiles obtained from FFPE and FF samples using the same platform. METHODS: Twenty-six FFPE-FF sample pairs of the same @entity5 representing various @entity5 types, and two FFPE-FF sample pairs of @entity0 cell lines, were included. Total RNA was extracted and gene expression profiling was carried out using Illumina's Whole-Genome cDNA-mediated Annealing, Selection, extension and Ligation (WG-DASL) V3 arrays, enabling the simultaneous detection of 24,526 mRNA transcripts. A sample exclusion criterion was created based on the expression of 11 stably expressed reference genes. Pearson correlation at the probe level was calculated for paired FFPE-FF, and three cut-off values were chosen. Spearman correlation coefficients between the matched FFPE and FF samples were calculated for three probe lists with varying levels of significance and compared to the correlation based on all measured probes. Unsupervised hierarchical cluster analysis was performed to verify performance of the included probe lists to compare matched FPPE-FF samples. RESULTS: Twenty-seven FFPE-FF pairs passed the sample exclusion criterion. From the profiles of 27 FFPE and FF matched samples, the best correlating probes were identified for various levels of significance (Pearson P<0.01, n = 1,432; P<0.05, n = 2,530; and P<0.10, n = 3,351 probes). Unsupervised hierarchical clustering of the 27 pairs using the resulting probes yielded 25, 21, and 19 correctly clustered pairs, respectively, compared to 1 pair when all probes were used. CONCLUSION: The proposed method enables comparison of gene expression profiles of FFPE and/or FF origin measured on the same platform.

title: A Method to Correlate mRNA Expression Datasets Obtained from Fresh Frozen and XXXX -Fixed, @entity982 -Embedded Tissue Samples: A Matter of Thresholds.

answer: @entity406 :: (MESH:D005557,Chemical) :: ['Formalin']


abstract: INTRODUCTION: @entity158 , mood problems and sleeping difficulties are often comorbid and contribute to reduced physical function and quality of life for those suffering from @entity1118 . However, the way in which these factors interact is unclear. Until recently it was thought that the effect of sleep on @entity158 and physical function was simply a result of its common association with mood problems. However, a growing body of research suggests that sleep may have a unique contribution. OBJECTIVES: The aim of this study was to determine whether @entity25 were associated with @entity158 and poor physical function independent of @entity458 in @entity1 attending a tertiary @entity158 medicine unit. METHOD: 101 @entity1 with @entity1118 completed a set of questionnaires measuring @entity158 , sleep and mood, and also completed a selection of physical assessments conducted by a physiotherapist. RESULTS: 75.2% of @entity1 had @entity22 and 84.3% reported the presence of at least one @entity25 . Significant positive correlations with @entity158 were detected for @entity308 , @entity16839 , @entity22 , short sleep duration and poor sleep quality. Sleep duration had a significant independent association with @entity158 after accounting for @entity308 and @entity16839 . Sleep duration also had an independent association with physical function after accounting for @entity158 and @entity16839 . CONCLUSIONS: Given that sleep has an important and unique contribution to @entity158 and physical function, it is important that @entity25 are addressed both in the assessment and treatment of @entity1118 .

title: Sleep Problems are Associated with @entity1118 Over and Above Mutual Associations with XXXX and Catastrophizing.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity16839 :: ('MESH:D002388', 'Disease') :: ['catastrophizing']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleep disturbances', 'sleep problem']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: INTRODUCTION: @entity158 , mood problems and sleeping difficulties are often comorbid and contribute to reduced physical function and quality of life for those suffering from @entity1118 . However, the way in which these factors interact is unclear. Until recently it was thought that the effect of sleep on @entity158 and physical function was simply a result of its common association with mood problems. However, a growing body of research suggests that sleep may have a unique contribution. OBJECTIVES: The aim of this study was to determine whether @entity25 were associated with @entity158 and poor physical function independent of @entity458 in @entity1 attending a tertiary @entity158 medicine unit. METHOD: 101 @entity1 with @entity1118 completed a set of questionnaires measuring @entity158 , sleep and mood, and also completed a selection of physical assessments conducted by a physiotherapist. RESULTS: 75.2% of @entity1 had @entity22 and 84.3% reported the presence of at least one @entity25 . Significant positive correlations with @entity158 were detected for @entity308 , @entity16839 , @entity22 , short sleep duration and poor sleep quality. Sleep duration had a significant independent association with @entity158 after accounting for @entity308 and @entity16839 . Sleep duration also had an independent association with physical function after accounting for @entity158 and @entity16839 . CONCLUSIONS: Given that sleep has an important and unique contribution to @entity158 and physical function, it is important that @entity25 are addressed both in the assessment and treatment of @entity1118 .

title: Sleep Problems are Associated with XXXX Over and Above Mutual Associations with @entity308 and Catastrophizing.

answer: @entity1118 :: (MESH:D059350,Disease) :: ['Chronic Pain']


abstract: BACKGROUND: The perceptions of @entity1 and physicians regarding the symptoms and impact of @entity2023 ( @entity2023 ) were assessed in a prospective, cross-sectional, international survey. This paper presents the combined survey results from five European countries (Germany, France, Italy, Spain and the UK). METHODS: Data were recorded by 1,482 @entity1 and matched with records from 415 primary care physicians and specialists. Diagnostic tests to confirm @entity2023 had been performed on 1,279 (86.3%) @entity1 . Both physicians and @entity1 recorded the presence, severity and impact of symptoms at the time of consultation in addition to those symptoms frequently, but not currently, present. Health-related quality of life (HRQoL) was assessed using the Mini @entity7370 Quality of Life Questionnaire. RESULTS: A large proportion of @entity1 had moderate-severe disease (67.2%; n = 996), persistent disease (42.5%; n = 630) and comorbidities such as @entity565 (31.5%; n = 467). Overall, @entity1 rated their disease as more severe than did physicians (P < 0.001). At the time of the consultation, one-third of all @entity1 reported that their current nasal and ocular symptoms were moderate or severe in nature. According to the physicians' assessment, good control of nasal and ocular symptoms was achieved in 45.4% (n = 673) and 51.3% (n = 760) of @entity1 , respectively, and poor symptom control in 18.0% (n = 267) and 12.1% (n = 179). Overall, 43.3% (n = 641) of those surveyed were using two or more medicines for their @entity2023 . Health-related quality of life was correlated with disease severity and with the number of days without symptoms in the previous 4 weeks. @entity2023 had a significantly greater impact in @entity1 with more persistent disease than in those with @entity66 (2.3 +/- 1.3 vs 1.9 +/- 1.2; P < 0.001). Nonetheless, 81.8% (n = 601) of @entity1 with @entity66 reported some impairment of their daily life as a result of their @entity2023 . CONCLUSIONS: @entity2023 remains a significant health problem because of the high burden of symptoms and its impact on general well being and HRQoL among @entity1 consulting for this condition. Overall, there was a poor correlation between @entity1 and physicians in the reporting of disease severity.

title: A survey of the burden of XXXX in Europe.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity7370 :: ('OMIM:613207', 'Disease') :: ['Rhinoconjunctivitis']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic rhinitis', 'AR', 'allergic rhinitis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['intermittent disease']

answer: @entity2023 :: (MESH:D006255,Disease) :: ['allergic rhinitis']


abstract: In general, it has been reported that @entity6425 was detected year round in tropical countries. However, studies in Venezuela and Brazil suggest a seasonal behavior of the @entity281 . On the other hand, some studies link @entity281 with climatic variables such as rainfall. This study analyzes the pattern of behavior of the @entity6425 in Carabobo-Venezuela (2001-2005), associates the seasonality of the @entity281 with rainfall, and according to the seasonal pattern, estimates the age of greatest risk for @entity281 . The analysis of the rotavirus temporal series and accumulated precipitation was performed with the software SPSS. The @entity281 showed two periods: high incidence (November-April) and low incidence (May-October). Accumulated precipitation presents an opposite behavior. The highest frequency of events (73.8% 573/779) for those born in the period with a low incidence of the virus was recorded at an earlier age (mean age 6.5 +/- 2.0 months) when compared with those born in the station of high incidence (63.5% 568/870, mean age 11.7 +/- 2.2 months). Seasonality of the @entity281 and the inverse relationship between virus incidence and rainfall was demonstrated. In addition, it was found that the period of birth determines the age and risk of @entity281 . This information generated during the preaccine period will be helpful to measure the impact of the vaccine against the rotavirus.

title: [Seasonality of XXXX in Venezuela: relationship between monthly rotavirus incidence and rainfall rates].

entities_list: @entity6425 :: ('MESH:D012400', 'Disease') :: ['rotavirus infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity6425 :: (MESH:D012400,Disease) :: ['rotavirus infection']


abstract: Field plot experiment was carried out to study the effect of @entity3151 application on soil @entity3151 adsorption-desorption characteristics under three cropping patterns including @entity2829 / @entity1460 relay intercropping (M/S), maize monoculture (M), and @entity1460 monoculture (S). Results showed that without @entity3151 fertilization, the system crop yield under M/S was increased by 9.8% and 79. 1% compared with that of M and S, respectively, and the land equivalent ratio (LER) was 1.58. With @entity4613 fertilizer application, the system crop yield under M/S was increased by 10.4% and 80.3% compared with that of M and S, respectively, and the LER was 1.62. The system crop yields under M/S, M and S with @entity4613 fertilizer application were increased by 12.7%, 12. 2% and 17. 6%, respectively, compared with that without @entity3151 fertilization. Among three cropping patterns, the soil buffer capacity (SBC) values were in the order of M/S>M >S regardless of @entity4613 fertilizer applied or not. The SBC values of M/S, M and S without @entity4613 fertilizer application were reduced by 19.6%, 30.3% and 12.0% compared with @entity4613 fertilizer application treatments, respectively. The soil desorption per absorption (b) values of the three cropping patterns with @entity4613 fertilizer application were in the order of M/S>M>S, and the b values increased by 10.9%, 39.1% and -9.6%, respectively, compared with non @entity4613 fertilizer application. The soil @entity3151 maximum absorption (Qm) and soil @entity3151 desorption rate also showed the same trend.

title: [Dynamics of soil @entity3151 adsorption-desorption in @entity2829 / XXXX relay intercropping system in purple hilly area].

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']

answer: @entity1460 :: (3847,Species) :: ['soybean']


abstract: Field plot experiment was carried out to study the effect of @entity3151 application on soil @entity3151 adsorption-desorption characteristics under three cropping patterns including @entity2829 / @entity1460 relay intercropping (M/S), maize monoculture (M), and @entity1460 monoculture (S). Results showed that without @entity3151 fertilization, the system crop yield under M/S was increased by 9.8% and 79. 1% compared with that of M and S, respectively, and the land equivalent ratio (LER) was 1.58. With @entity4613 fertilizer application, the system crop yield under M/S was increased by 10.4% and 80.3% compared with that of M and S, respectively, and the LER was 1.62. The system crop yields under M/S, M and S with @entity4613 fertilizer application were increased by 12.7%, 12. 2% and 17. 6%, respectively, compared with that without @entity3151 fertilization. Among three cropping patterns, the soil buffer capacity (SBC) values were in the order of M/S>M >S regardless of @entity4613 fertilizer applied or not. The SBC values of M/S, M and S without @entity4613 fertilizer application were reduced by 19.6%, 30.3% and 12.0% compared with @entity4613 fertilizer application treatments, respectively. The soil desorption per absorption (b) values of the three cropping patterns with @entity4613 fertilizer application were in the order of M/S>M>S, and the b values increased by 10.9%, 39.1% and -9.6%, respectively, compared with non @entity4613 fertilizer application. The soil @entity3151 maximum absorption (Qm) and soil @entity3151 desorption rate also showed the same trend.

title: [Dynamics of soil @entity3151 adsorption-desorption in XXXX / @entity1460 relay intercropping system in purple hilly area].

answer: @entity2829 :: (4577,Species) :: ['maize']


abstract: Field plot experiment was carried out to study the effect of @entity3151 application on soil @entity3151 adsorption-desorption characteristics under three cropping patterns including @entity2829 / @entity1460 relay intercropping (M/S), maize monoculture (M), and @entity1460 monoculture (S). Results showed that without @entity3151 fertilization, the system crop yield under M/S was increased by 9.8% and 79. 1% compared with that of M and S, respectively, and the land equivalent ratio (LER) was 1.58. With @entity4613 fertilizer application, the system crop yield under M/S was increased by 10.4% and 80.3% compared with that of M and S, respectively, and the LER was 1.62. The system crop yields under M/S, M and S with @entity4613 fertilizer application were increased by 12.7%, 12. 2% and 17. 6%, respectively, compared with that without @entity3151 fertilization. Among three cropping patterns, the soil buffer capacity (SBC) values were in the order of M/S>M >S regardless of @entity4613 fertilizer applied or not. The SBC values of M/S, M and S without @entity4613 fertilizer application were reduced by 19.6%, 30.3% and 12.0% compared with @entity4613 fertilizer application treatments, respectively. The soil desorption per absorption (b) values of the three cropping patterns with @entity4613 fertilizer application were in the order of M/S>M>S, and the b values increased by 10.9%, 39.1% and -9.6%, respectively, compared with non @entity4613 fertilizer application. The soil @entity3151 maximum absorption (Qm) and soil @entity3151 desorption rate also showed the same trend.

title: [Dynamics of soil XXXX adsorption-desorption in @entity2829 / @entity1460 relay intercropping system in purple hilly area].

answer: @entity3151 :: (MESH:D010758,Chemical) :: ['phosphorus']


abstract: OBJECTIVE: To analyze the outcomes of synchronous revascularization for @entity1 concomitant carotid and coronary artery severe @entity850 . METHODS: From May 2012 to April 2014, 12 cases who received one-stage operation was retrospective analyzed, including the characteristics, methods of treatment, perioperative complications and health survey 30 days post procedure. Two subgroups were divided according to the different treatment methods on carotid artery, WIC and SF-36 scale were applied to compare the basic condition and recovery situation between 2 groups, the hospital stay time, costs, ventilation time, drainage and blood transfusion volume were also be compared. RESULTS: Totally 30 coronary vessels 8 carotid endarterectomy (CEA) and 5 @entity2998 ( @entity2998 ) were performed on 12 @entity1 . One @entity1 also received coronary artery bypass grafting and bilateral carotid artery revascularization (CEA on right and @entity2998 on left). Two (16.67%) minor @entity64 , 1 (8.33%) TIA, 1 wound @entity281 occurred within 30 days post procedure, and 11 (91.67%) received blood component transfusion. No @entity583 and @entity204 occured. The average hospital stay time were (36.5    25.3) days, ventilator application (37.5    31.2) hours, postoperative drainage volume from pericardial and mediastinal was (347.92    105.69) ml, infusion of concentrated red cell was 4.3 U. WIC was (5.57    1.51) in CEA and (4.25    1.50) in @entity2998 subgroup, there was no significantly statistical difference (t = 1.40, P > 0.05). the results of SF-36 was (3.63    1.76) and (5.44    1.05) in CEA and @entity2998 subgroup, there was no significantly statistical difference (t = -1.85, P > 0.05). In hospital stay time, ventilator application time, transfusion and drainage volume, hospitalization costs were also no significant statistical difference between two groups. CONCLUSIONS: The early outcome of synchronous revascularization on concomitant carotid and coronary severe @entity850 disease is satisfactory. The clinical results are similar in the CEA and @entity2998 subgroup.

title: [Clinical outcomes of synchronous revascularization on @entity1 concomitant carotid and coronary artery severe XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid artery stenting', 'CAS']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity850 :: (MESH:D003251,Disease) :: ['stenosis']


abstract: OBJECTIVE: To analyze the outcomes of synchronous revascularization for @entity1 concomitant carotid and coronary artery severe @entity850 . METHODS: From May 2012 to April 2014, 12 cases who received one-stage operation was retrospective analyzed, including the characteristics, methods of treatment, perioperative complications and health survey 30 days post procedure. Two subgroups were divided according to the different treatment methods on carotid artery, WIC and SF-36 scale were applied to compare the basic condition and recovery situation between 2 groups, the hospital stay time, costs, ventilation time, drainage and blood transfusion volume were also be compared. RESULTS: Totally 30 coronary vessels 8 carotid endarterectomy (CEA) and 5 @entity2998 ( @entity2998 ) were performed on 12 @entity1 . One @entity1 also received coronary artery bypass grafting and bilateral carotid artery revascularization (CEA on right and @entity2998 on left). Two (16.67%) minor @entity64 , 1 (8.33%) TIA, 1 wound @entity281 occurred within 30 days post procedure, and 11 (91.67%) received blood component transfusion. No @entity583 and @entity204 occured. The average hospital stay time were (36.5    25.3) days, ventilator application (37.5    31.2) hours, postoperative drainage volume from pericardial and mediastinal was (347.92    105.69) ml, infusion of concentrated red cell was 4.3 U. WIC was (5.57    1.51) in CEA and (4.25    1.50) in @entity2998 subgroup, there was no significantly statistical difference (t = 1.40, P > 0.05). the results of SF-36 was (3.63    1.76) and (5.44    1.05) in CEA and @entity2998 subgroup, there was no significantly statistical difference (t = -1.85, P > 0.05). In hospital stay time, ventilator application time, transfusion and drainage volume, hospitalization costs were also no significant statistical difference between two groups. CONCLUSIONS: The early outcome of synchronous revascularization on concomitant carotid and coronary severe @entity850 disease is satisfactory. The clinical results are similar in the CEA and @entity2998 subgroup.

title: [Clinical outcomes of synchronous revascularization on XXXX concomitant carotid and coronary artery severe @entity850 ].

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To explore the computed tomography (CT) features and pathological correlations of primitive @entity4969 (PNET) of the kidney. METHODS: The CT features of 5 cases of pathologically confirmed PNETs were retrospectively reviewed along with a literature review to analyze the CT features and pathological correlations. RESULTS: The age range was 19-78 years. CT image showed solitary mass of heterogeneous density with ill-defined margins. One case had multifocal @entity39 . Among 3 cases of cystic changes, there were mural nodule (n = 2) and patchy @entity730 (n = 1). Four cases showed @entity8 with cortical interruption (n = 3) and destruction of renal capsule and invasion into perirenal fat space (n = 1). The @entity5 were confined to kidney contour with enlarged kidney (n = 3). All 5 cases showed slight heterogenous enhancement in cortico-medullary phase with persistent moderate enhancement (n = 4) and persistent mild enhancement (n = 1) in nephrographic phase. CONCLUSION: @entity703 is common in young @entity1 with a high degree of @entity5 . CT features include large mass with heterogenous density and poor-defined border confined within renal contour. Necrosis and cystic changes occur commonly with invasive growth. Persistent enhancement is found during nephrographic phase. A definite diagnosis is dependent upon pathological and immunohistochemical examinations.

title: [Computed tomography features and pathological correlations of primitive XXXX ].

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['invasive growth into renal cortex and pelvis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'tumors']

entities_list: @entity4969 :: ('MESH:D017599', 'Disease') :: ['neuroectodermal tumor']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['Renal PNET']

answer: @entity703 :: (MESH:D007680,Disease) :: ['neuroectodermal tumor of the kidney']


abstract: BACKGROUND: @entity17847 pathovar campestris (Xcc) is the causal agent of black rot disease of crucifers worldwide. The molecular genetic diversity and host specificity of Xcc are poorly understood. RESULTS: We constructed a microarray based on the complete genome sequence of Xcc strain 8004 and investigated the genetic diversity and host specificity of Xcc by array-based comparative genome hybridization analyses of 18 virulent strains. The results demonstrate that a genetic core comprising 3,405 of the 4,186 coding sequences (CDSs) spotted on the array are conserved and a flexible gene pool with 730 CDSs is @entity5770 ( @entity5770 ). The results also revealed that 258 of the 304 proved/presumed pathogenicity genes are conserved and 46 are @entity5770 . The conserved pathogenicity genes include mainly the genes involved in type I, II and III secretion systems, the quorum sensing system, extracellular enzymes and polysaccharide production, as well as many other proved pathogenicity genes, while the @entity5770 CDSs contain the genes encoding type IV secretion system (T4SS) and type III-effectors. A Xcc T4SS-deletion mutant displayed the same virulence as wild type. Furthermore, three avirulence genes (avrXccC, avrXccE1 and avrBs1) were identified. avrXccC and avrXccE1 conferred avirulence on the hosts mustard cultivar Guangtou and Chinese cabbage cultivar Zhongbai-83, respectively, and avrBs1 conferred hypersensitive response on the nonhost pepper ECW10R. CONCLUSION: About 80% of the Xcc CDSs, including 258 proved/presumed pathogenicity genes, is conserved in different strains. Xcc T4SS is not involved in pathogenicity. An efficient strategy to identify avr genes determining host specificity from the @entity5770 genes was developed.

title: Comparative and functional genomics reveals genetic diversity and determinants of host specificity among reference strains and a large collection of Chinese isolates of the phytopathogen XXXX pv. campestris.

entities_list: @entity17847 :: ('339', 'Species') :: ['Xanthomonas campestris']

entities_list: @entity5770 :: ('MESH:D005099', 'Disease') :: ['AHD', 'absent/highly divergent']

answer: @entity17847 :: (339,Species) :: ['Xanthomonas campestris']


abstract: UNASSIGNED: @entity6 ( @entity6 ) associates with increased @entity8561 transport and extracellular concentration of @entity859 in @entity1 umbilical vein endothelial cells (HUVECs). In this study we aim to determine whether insulin reverses @entity6 -increased @entity8561 transport requiring @entity859 receptors expression in HUVECs. Primary cultured HUVECs from full-term normal (n   =   38) and diet-treated @entity6 (n   =   38) pregnancies were used. Insulin effect was assayed on @entity1 cationic @entity3689 transporter 1 ( @entity35107 ) expression (protein, mRNA, @entity35107 promoter activity) and activity (initial rates of @entity8561 transport) in the absence or presence of @entity859 receptors agonists or antagonists. A1 @entity859 receptors (A1AR) and A2AAR expression (Western blot, quantitative PCR) was determined. Experiments were done in cells expressing or siRNA-suppressed expression of A1AR or A2AAR. HUVECs from @entity6 exhibit higher maximal transport capacity (maximal velocity (V max)/apparent Michaelis Menten constant (K m), V max/K m), which is blocked by insulin by reducing the V max to values in cells from normal pregnancies. Insulin also reversed the @entity6 -associated increase in @entity35107 protein abundance and mRNA expression, and @entity35107 promoter activity for the fragment -606  bp from the transcription start point. Insulin effects required A1AR, but not A2AAR expression and activity in this cell type. In the absence of insulin, @entity6 -increased @entity35107 expression and activity required A2AAR expression and activity. HUVECs from @entity6 pregnancies exhibit a differential requirement of A1AR or A2AAR depending on the level of insulin, a phenomenon that represent a condition where @entity859 or analogues of this @entity8742 could be acting as helpers of insulin biological effects in @entity6 .

title: Insulin requires A1 @entity859 receptors expression to reverse gestational diabetes-increased XXXX transport in @entity1 umbilical vein endothelium.

entities_list: @entity859 :: ('MESH:D000241', 'Chemical') :: ['adenosine']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Gestational diabetes mellitus', 'GDM']

answer: @entity8561 :: (D001120,Chemical) :: ['L-arginine']


abstract: UNASSIGNED: @entity6 ( @entity6 ) associates with increased @entity8561 transport and extracellular concentration of @entity859 in @entity1 umbilical vein endothelial cells (HUVECs). In this study we aim to determine whether insulin reverses @entity6 -increased @entity8561 transport requiring @entity859 receptors expression in HUVECs. Primary cultured HUVECs from full-term normal (n   =   38) and diet-treated @entity6 (n   =   38) pregnancies were used. Insulin effect was assayed on @entity1 cationic @entity3689 transporter 1 ( @entity35107 ) expression (protein, mRNA, @entity35107 promoter activity) and activity (initial rates of @entity8561 transport) in the absence or presence of @entity859 receptors agonists or antagonists. A1 @entity859 receptors (A1AR) and A2AAR expression (Western blot, quantitative PCR) was determined. Experiments were done in cells expressing or siRNA-suppressed expression of A1AR or A2AAR. HUVECs from @entity6 exhibit higher maximal transport capacity (maximal velocity (V max)/apparent Michaelis Menten constant (K m), V max/K m), which is blocked by insulin by reducing the V max to values in cells from normal pregnancies. Insulin also reversed the @entity6 -associated increase in @entity35107 protein abundance and mRNA expression, and @entity35107 promoter activity for the fragment -606  bp from the transcription start point. Insulin effects required A1AR, but not A2AAR expression and activity in this cell type. In the absence of insulin, @entity6 -increased @entity35107 expression and activity required A2AAR expression and activity. HUVECs from @entity6 pregnancies exhibit a differential requirement of A1AR or A2AAR depending on the level of insulin, a phenomenon that represent a condition where @entity859 or analogues of this @entity8742 could be acting as helpers of insulin biological effects in @entity6 .

title: Insulin requires A1 XXXX receptors expression to reverse gestational diabetes-increased @entity8561 transport in @entity1 umbilical vein endothelium.

answer: @entity859 :: (MESH:D000241,Chemical) :: ['adenosine']


abstract: UNASSIGNED: @entity6 ( @entity6 ) associates with increased @entity8561 transport and extracellular concentration of @entity859 in @entity1 umbilical vein endothelial cells (HUVECs). In this study we aim to determine whether insulin reverses @entity6 -increased @entity8561 transport requiring @entity859 receptors expression in HUVECs. Primary cultured HUVECs from full-term normal (n   =   38) and diet-treated @entity6 (n   =   38) pregnancies were used. Insulin effect was assayed on @entity1 cationic @entity3689 transporter 1 ( @entity35107 ) expression (protein, mRNA, @entity35107 promoter activity) and activity (initial rates of @entity8561 transport) in the absence or presence of @entity859 receptors agonists or antagonists. A1 @entity859 receptors (A1AR) and A2AAR expression (Western blot, quantitative PCR) was determined. Experiments were done in cells expressing or siRNA-suppressed expression of A1AR or A2AAR. HUVECs from @entity6 exhibit higher maximal transport capacity (maximal velocity (V max)/apparent Michaelis Menten constant (K m), V max/K m), which is blocked by insulin by reducing the V max to values in cells from normal pregnancies. Insulin also reversed the @entity6 -associated increase in @entity35107 protein abundance and mRNA expression, and @entity35107 promoter activity for the fragment -606  bp from the transcription start point. Insulin effects required A1AR, but not A2AAR expression and activity in this cell type. In the absence of insulin, @entity6 -increased @entity35107 expression and activity required A2AAR expression and activity. HUVECs from @entity6 pregnancies exhibit a differential requirement of A1AR or A2AAR depending on the level of insulin, a phenomenon that represent a condition where @entity859 or analogues of this @entity8742 could be acting as helpers of insulin biological effects in @entity6 .

title: Insulin requires A1 @entity859 receptors expression to reverse gestational diabetes-increased @entity8561 transport in XXXX umbilical vein endothelium.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: To explore the clinical characteristics of retroperitoneal malignant @entity82 ( @entity1418 ) and to retrospectively evaluate the outcome of treatment and identify prognostic factors for survival time. METHODS: The records of 38 @entity1 with retroperitoneal malignant @entity82 ( @entity1418 ) managed with surgery from March 2000 to August 2013 were retrospectively reviewed. RESULTS: All @entity1 received surgical resection, including 23 @entity5 and 15 recurrent @entity5 . 20 @entity1 received radical resection, 18 cases received palliative resection. The 19 @entity1 (95%) received complete resection got @entity5 recurrence. The overall 1-, 3-, 5-year survival rate were 62.9%, 35.2% and 4.4% and the median survival time was 15.5 (1-157) months. Log-rank test indicated that @entity5 grade ((  (2) = 10.667, P < 0.01) and radical surgery (  (2) = 18.476, P < 0.01) were associated with postoperative survival time. The difference between gender ((  (2) = 3.329, P = 0.068), age ((  (2) = 0.426, P = 0.514), removal of the joint organs ((  (2) = 3.725, P = 0.054), blood transfusion ((  (2) = 0.044, P = 0.833), @entity5 size ((  (2) = 1.647, P = 0.199), @entity5 metastasis ((  (2) = 0.345, P = 0.557), adjuvant therapy ((  (2) = 1.992, P = 0.158), recurrent disease ((  (2) = 0.163, P = 0.640) got no statistical significance. Multivariate analysis indicated that radical surgery and @entity5 grade were prognostic indicators for retroperitoneal malignant @entity82 (RR = 4.888, P = 0.001; HR = 4.436, P = 0.006). CONCLUSIONS: @entity1418 ( @entity1418 ) has high malignant degree and is difficult to treat. The prognosis is poor. Complete resection remains the main method for retroperitoneal malignant @entity82 . It often requires the resection of other adjacent organs in order to reach the goal of radical resection. Incomplete resection and high grade (grade 3) predict shorter postoperative survival time.

title: [Clinical analysis of diagnosis and treatment for retroperitoneal malignant XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrous histiocytoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors', 'tumors']

entities_list: @entity1418 :: ('MESH:D051677', 'Disease') :: ['Malignant fibrous histiocytoma', 'MFH']

answer: @entity82 :: (MESH:D005355,Disease) :: ['fibrous histiocytoma']


abstract: The interactions of outer membrane proteins (OMPs) with the periplasmic chaperone Skp from @entity526 are not well understood. We have examined the binding of Skp to various OMPs of different origin, size, and function. These were OmpA, OmpG, and YaeT (Omp85) from @entity526 , the translocator domain of the autotransporter NalP from Neisseria meningitides, FomA from @entity8209 , and the voltage-dependent anion-selective channel, @entity1 isoform 1 ( @entity20600 ) from mitochondria. Binding of Skp was observed for bacterial OMPs, but neither for @entity20600 nor for soluble bovine serum albumin. The Skp trimer formed 1:1 complexes, OMP.Skp(3), with bacterial OMPs, independent of their size or origin. The dissociation constants of these OMP.Skp(3) complexes were all in the nanomolar range, indicating that they are stable. Complexes of Skp(3) with YaeT displayed the smallest dissociation constants, complexes with NalP the largest. OMP binding to Skp(3) was pH-dependent and not observed when either Skp or OMPs were neutralized at very basic or very acidic pH. When the ionic strength was increased, the free energies of binding of Skp to OmpA or OmpG were reduced. Electrostatic interactions were therefore necessary for formation and stability of OMP.Skp(3) complexes. Light-scattering and circular dichroism experiments demonstrated that Skp(3) remained a stable trimer from pH 3 to pH 11. In the OmpA.Skp(3) complex, Skp efficiently shielded @entity2340 residues of the transmembrane strands of OmpA against fluorescence quenching by aqueous @entity3323 . Lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria, bound to OmpA.Skp(3) complexes at low stoichiometries. @entity3323 quenching of fluorescence indicated that in this ternary complex, the @entity2340 residues of the transmembrane domain of OmpA were located closer to the surface than in binary OmpA.Skp(3) complexes. This may explain previous observations that folding of Skp-bound OmpA into lipid bilayers is facilitated in presence of LPS.

title: The trimeric periplasmic chaperone Skp of XXXX forms 1:1 complexes with outer membrane proteins via hydrophobic and electrostatic interactions.

entities_list: @entity8209 :: ('851', 'Species') :: ['Fusobacterium nucleatum']

entities_list: @entity2340 :: ('CHEBI:27897', 'Chemical') :: ['tryptophan']

entities_list: @entity3323 :: ('MESH:D020106', 'Chemical') :: ['acrylamide', 'Acrylamide']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity526 :: (562,Species) :: ['Escherichia coli']