abstract: Induction of ischemic tolerance (IT), the ability of an organism to survive an otherwise lethal @entity63 , is the most effective known approach to preventing @entity16 . IT can be induced by exposing animals to a broad range of stimuli. In this study we tried to induce IT of brain neurons using ionizing radiation (IR). A preconditioning (pre-C) dose of 10, 20, 30 or 50 Gy of gamma rays was used 2 days before an 8 min @entity63 in adult male @entity35 . @entity63 alone caused the degeneration of almost one half of neurons in @entity1249 region of hippocampus. However, a significant decrease of the number of degenerating neurons was observed after higher doses of radiation (30 and 50 Gy). Moreover, @entity63 significantly impaired the spatial memory of @entity35 as tested in Morris's water maze. In @entity35 with a 50 Gy pre-C dose, the latency times were reduced to values close to the control level. Our study is the first to reveal that IR applied in sufficient doses can induce IT and thus allow pyramidal @entity1249 neurons to survive @entity63 . In addition, we show that the beneficial effect of IR pre-C is proportional to the radiation dose.

title: Ionizing radiation as preconditioning against transient cerebral ischemia in XXXX .

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['postischemic damage']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['Ischemia', 'ischemia']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: PURPOSE: To compare the efficacy of two different techniques for vertical bone regeneration at implant placement with particulate autogenous bone at 6 years after loading by means of a double-blind, superiority, parallel-group randomized clinical trial. MATERIALS AND METHODS: The study was conducted in a private center in Italy between April 2004 and December 2011. @entity1 in whom vertical bone augmentation was indicated in combination with the placement of single or multiple implants were eligible for inclusion in this trial. @entity1 were randomized to receive either resorbable collagen barriers supported by an osteosynthesis plate (test group) or nonresorbable @entity702 -reinforced expanded @entity736 barriers (control group). The outcome variables-radiographic bone variation at implant sites, implant failures, and complications- were evaluated 6 years after loading. Randomization was done by computer, with allocation concealed by opaque sequentially numbered sealed envelopes. The @entity1 and the radiographic examiner were blinded to group assignment. RESULTS: Twenty-two @entity1 were randomized: 11 to the resorbable barrier group and 11 to the nonresorbable (control) group. One control group @entity1 dropped out. The mean bone level 6 years after surgery was 1.33 mm for the resorbable group and 1.00 mm for the nonresorbable group. The adjusted difference in bone changes between groups was 0.15 mm (95% confidence interval, -0.39 to 0.69, P = .5713). No implant failures or complications occurred after loading. CONCLUSION: No differences were observed in this comparison of resorbable and nonresorbable barriers with simultaneous implant placement for vertical ridge augmentation.

title: Bone level variation after vertical ridge augmentation: resorbable barriers versus XXXX -reinforced barriers. A 6-year double-blind randomized clinical trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium']

entities_list: @entity736 :: ('CHEBI:53251', 'Chemical') :: ['polytetrafluoroethylene']

answer: @entity702 :: (MESH:D014025,Chemical) :: ['titanium']


abstract: Balance control (the ability to maintain an upright posture) is asymmetrically controlled in a proportion of @entity1 with @entity191 . Gait asymmetries have been linked to the pathophysiology of freezing of gait. We speculate that asymmetries in balance could contribute to freezing by a) hampering the unloading of the stepping leg and/or b) leading to a preferred stance leg during gait, which then results in asymmetric gait. To investigate this, we examined the relationship between balance control and weight-bearing asymmetries and freezing. We included 20 @entity1 @entity1 with @entity304 (tested OFF medication; nine freezers) and nine healthy controls. Balance was perturbed in the sagittal plane, using continuous multi-sine perturbations, applied by a motion platform and by a force at the sacrum. Applying closed-loop system identification techniques, relating the body sway angle to the joint torques of each leg separately, determined the relative contribution of each ankle and hip joint to the total amount of joint torque. We also calculated weight-bearing asymmetries. We determined the 99-percent confidence interval of weight-bearing and balance-control asymmetry using the responses of the healthy controls. Freezers did not have larger asymmetries in weight bearing (p=0.85) nor more asymmetrical balance control compared to non-freezers (p=0.25). The healthy linear one-to-one relationship between weight bearing and balance control was significantly different for freezers and non-freezers (p=0.01). Specifically, non-freezers had a significant relationship between weight bearing and balance control (p=0.02), whereas this relation was not significant for freezers (p=0.15). Balance control is asymmetrical in most @entity1 (about 75 percent) with @entity191 , but this asymmetry is not related to freezing. The relationship between weight bearing and balance control seems to be less pronounced in freezers, compared to healthy controls and non-freezers. However, this relationship should be investigated further in larger groups of @entity1 .

title: Balance asymmetry in XXXX and its contribution to freezing of gait.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinson']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: UNASSIGNED: The Jarisch-Herxheimer reaction (JHR) is a transient @entity32 triggered hours after the start of antibiotic treatment of @entity24553 , namely syphilis. Clinically, JHR manifests as an abrupt onset of constitutional symptoms and exacerbation of cutaneous lesions that resolve without intervention. JHR's pathogenesis is unclear and it is histopathologically rarely reported. Herein, the authors report a 47-year-old @entity1 , with solitary @entity8831 and positive Lyme disease serology, who presented for medical care 14 days after commencement of @entity3403 therapy. She complained of malaise, facial @entity1671 , and acquisition of additional plaques characterized by swelling, @entity5105 , @entity111 , and exfoliative scale. Punch biopsies demonstrated subacute to chronic spongiotic psoriasiform reaction patterns with a superficial lymphocytic infiltrate. By Borrelia-specific immunohistochemistry, spirochetes were found in the deep dermis, unassociated with @entity32 , and focally in the upper spinous layer, associated with spongiosis. @entity2069 DNA was detected by nested polymerase chain reaction. @entity3403 was discontinued, and symptoms and signs resolved within a few days. Liberation of endotoxin-like materials (eg, lipoproteins) from degenerating spirochetes and concomitant cytokine production is the suspected cause of JHR and supported by the finding of lesional spirochetes. Alternatively, a reversal reaction with a @entity56 reaction is also a plausible cause based on spirochetes found in the @entity1909 .

title: Delayed Onset of the Jarisch-Herxheimer Reaction in XXXX -Treated Disease: A Case Report and Review of its Histopathology and Implications for Pathogenesis.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory syndrome', 'inflammation']

entities_list: @entity1671 :: ('MESH:D005483', 'Disease') :: ['flushing, gingival erythema']

entities_list: @entity3403 :: ('MESH:D004318', 'Chemical') :: ['Doxycycline', 'doxycycline']

entities_list: @entity2069 :: ('139', 'Species') :: ['Borrelia burgdorferi']

entities_list: @entity8831 :: ('MESH:C538499', 'Disease') :: ['erythema migrans']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity5105 :: ('MESH:D004890', 'Disease') :: ['increased erythema']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['delayed-type hypersensitivity']

entities_list: @entity24553 :: ('MESH:D013145', 'Disease') :: ['spirochete infections']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['lymphocytic spongiotic dermatitis']

answer: @entity3403 :: (MESH:D004318,Chemical) :: ['Doxycycline']


abstract: @entity16109 (NiV) causes fatal @entity281 in @entity1 . To characterize the role of the matrix (M) protein in the viral life cycle, we generated a reverse genetics system based on @entity778 . Using an enhanced green fluorescent protein (eGFP)-expressing M protein-deleted NiV, we observed a slightly increased cell-cell fusion, slow replication kinetics, and significantly reduced peak titers compared to the parental virus. While increased amounts of viral proteins were found in the supernatant of cells infected with M-deleted NiV, the infectivity-to-particle ratio was more than 100-fold reduced, and the particles were less thermostable and of more irregular morphology. Taken together, our data demonstrate that the M protein is not absolutely required for the production of cell-free NiV but is necessary for proper assembly and release of stable infectious NiV particles. IMPORTANCE: Henipaviruses cause a severe disease with high mortality in @entity1 @entity1 . Therefore, these viruses can be studied only in biosafety level 4 (BSL-4) laboratories, making it more challenging to characterize their life cycle. Here we investigated the role of the @entity16109 matrix protein in virus-mediated cell-cell fusion and in the formation and release of newly produced particles. We found that even though low levels of infectious viruses are produced in the absence of the matrix protein, it is required for the release of highly infectious and stable particles. Fusogenicity of matrixless viruses was slightly enhanced, further demonstrating the critical role of this protein in different steps of @entity16109 spread.

title: XXXX Matrix Protein Influences Fusogenicity and Is Essential for Particle Infectivity and Stability.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['encephalitic infections']

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['NiV strain Malaysia']

answer: @entity16109 :: (121791,Species) :: ['Nipah Virus']


abstract: UNASSIGNED: @entity174 healing is characterized by an intense increase in modeling and remodeling of bone, which allows removal of the cast after a stable @entity174 within 3 to 5 weeks. However, at that time, bone strength has not recovered yet. We studied the changes in @entity79 ( @entity79 ), microarchitecture, and @entity79 after a @entity174 during a 2-year follow-up in comparison to the contralateral side and the association between the 2-year stiffness and baseline @entity79 , microarchitecture, and early changes in these parameters. The fractured side of 14 postmenopausal @entity1 (mean age 64        8 years) with a conservatively treated @entity174 was scanned by high-resolution peripheral quantitative computed tomography (HRpQCT) at 1 to 2, 3 to 4, 6 to 8, and 12 weeks and 2 years postfracture. The same region contralaterally was scanned as well at the 2-year visit. @entity79 , microarchitecture, and stiffness parameters were determined and the @entity174 side was compared with the contralateral side using a linear mixed-effect model. Spearman's correlation was used to correlate the 2-year @entity79 with baseline @entity79 , microarchitecture, and early 3-month changes in these parameters. Two years postfracture, cortical and trabecular thickness and torsional and bending stiffness were significantly higher at the fractured side compared with the nonfractured side (21%, 55%, 31%, and 29%, respectively, p < 0.05), whereas @entity79 was similar. Two-year torsional and bending stiffness correlated significantly with baseline @entity79 and cortical perimeter ( rho  >=  0.63, p < 0.016) but not with early changes in bone parameters. Using HRpQCT, this study illustrates that @entity174 healing is not completed by the time the cast is removed. We showed that from 6 weeks to 2 years postfracture, large changes occur in @entity79 , microarchitecture, and biomechanical parameters at the fractured side, which were fully recovered after 2 years in comparison to the nonfractured contralateral side. Interestingly, higher 2-year torsional and bending stiffness were associated with lower @entity79 and higher cortical perimeter at baseline.    2015 American Society for Bone and Mineral Research.

title: XXXX Repair in the Distal Radius in Postmenopausal @entity1 : A Follow-Up 2 Years Postfracture Using HRpQCT.

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone stiffness', 'bone mineral density', 'BMD']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['distal radius fracture', 'Fracture', 'fracture']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Fracture']


abstract: UNASSIGNED: @entity174 healing is characterized by an intense increase in modeling and remodeling of bone, which allows removal of the cast after a stable @entity174 within 3 to 5 weeks. However, at that time, bone strength has not recovered yet. We studied the changes in @entity79 ( @entity79 ), microarchitecture, and @entity79 after a @entity174 during a 2-year follow-up in comparison to the contralateral side and the association between the 2-year stiffness and baseline @entity79 , microarchitecture, and early changes in these parameters. The fractured side of 14 postmenopausal @entity1 (mean age 64        8 years) with a conservatively treated @entity174 was scanned by high-resolution peripheral quantitative computed tomography (HRpQCT) at 1 to 2, 3 to 4, 6 to 8, and 12 weeks and 2 years postfracture. The same region contralaterally was scanned as well at the 2-year visit. @entity79 , microarchitecture, and stiffness parameters were determined and the @entity174 side was compared with the contralateral side using a linear mixed-effect model. Spearman's correlation was used to correlate the 2-year @entity79 with baseline @entity79 , microarchitecture, and early 3-month changes in these parameters. Two years postfracture, cortical and trabecular thickness and torsional and bending stiffness were significantly higher at the fractured side compared with the nonfractured side (21%, 55%, 31%, and 29%, respectively, p < 0.05), whereas @entity79 was similar. Two-year torsional and bending stiffness correlated significantly with baseline @entity79 and cortical perimeter ( rho  >=  0.63, p < 0.016) but not with early changes in bone parameters. Using HRpQCT, this study illustrates that @entity174 healing is not completed by the time the cast is removed. We showed that from 6 weeks to 2 years postfracture, large changes occur in @entity79 , microarchitecture, and biomechanical parameters at the fractured side, which were fully recovered after 2 years in comparison to the nonfractured contralateral side. Interestingly, higher 2-year torsional and bending stiffness were associated with lower @entity79 and higher cortical perimeter at baseline.    2015 American Society for Bone and Mineral Research.

title: @entity174 Repair in the Distal Radius in Postmenopausal XXXX : A Follow-Up 2 Years Postfracture Using HRpQCT.

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: Despite the known benefits of early treatment initiation for individual morbidity and mortality, as well as for reducing the risk of transmission, late presentation (LP) to @entity645 / @entity791 services remains a major concern in many countries. There is little information on LP from middle- and low-income countries and studies that do evaluate LP commonly disaggregate data by sex. It is rare, however, for researchers to further disaggregate the data by pregnancy status so it remains unclear if pregnancy status modifies the effects associated with sex. The study was conducted at the only State Reference Center for @entity645 / @entity791 in Salvador, Brazil's third largest city. LP was defined as a @entity1 accessing services with a @entity404 < 350 cells/mm(3). Data were abstracted from the electronic medical records of 1421 @entity1 presenting between 2007 and 2009. @entity404 counts and viral load (VL) information was validated with data from the National @entity404 /VL Database. Descriptive and bivariate statistics were conducted to inform the multivariate analysis. Adjusted prevalence ratios (APR) were estimated using generalized linear models due to the high frequency of the outcome. Half of the sample (52.5%; n = 621) was classified as LP. Compared to the prevalence among pregnant @entity1 (21.1%), the prevalence of LP was more than twice as high among non-pregnant @entity1 (56.0%) and among @entity1 (55.4%). The multivariate analysis demonstrated no statistical difference between @entity1 and nonpregnant @entity1 ( @entity18451 .04; 95%CI 0.92-1.19), but the APR of LP for nonpregnant @entity1 was 53% less than @entity1 (APR 0.47; 95%CI 0.33-0.68). These results highlight the importance of analyzing data disaggregated not only by sex but also by pregnancy status to accurately identify the risk factors associated with LP so that programs and policies can effectively and efficiently address LP in Brazil and beyond.

title: What's pregnancy got to do with it? Late presentation to @entity645 / XXXX services in Northeastern Brazil.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

answer: @entity791 :: (MESH:D000163,Disease) :: ['AIDS']


abstract: Despite the known benefits of early treatment initiation for individual morbidity and mortality, as well as for reducing the risk of transmission, late presentation (LP) to @entity645 / @entity791 services remains a major concern in many countries. There is little information on LP from middle- and low-income countries and studies that do evaluate LP commonly disaggregate data by sex. It is rare, however, for researchers to further disaggregate the data by pregnancy status so it remains unclear if pregnancy status modifies the effects associated with sex. The study was conducted at the only State Reference Center for @entity645 / @entity791 in Salvador, Brazil's third largest city. LP was defined as a @entity1 accessing services with a @entity404 < 350 cells/mm(3). Data were abstracted from the electronic medical records of 1421 @entity1 presenting between 2007 and 2009. @entity404 counts and viral load (VL) information was validated with data from the National @entity404 /VL Database. Descriptive and bivariate statistics were conducted to inform the multivariate analysis. Adjusted prevalence ratios (APR) were estimated using generalized linear models due to the high frequency of the outcome. Half of the sample (52.5%; n = 621) was classified as LP. Compared to the prevalence among pregnant @entity1 (21.1%), the prevalence of LP was more than twice as high among non-pregnant @entity1 (56.0%) and among @entity1 (55.4%). The multivariate analysis demonstrated no statistical difference between @entity1 and nonpregnant @entity1 ( @entity18451 .04; 95%CI 0.92-1.19), but the APR of LP for nonpregnant @entity1 was 53% less than @entity1 (APR 0.47; 95%CI 0.33-0.68). These results highlight the importance of analyzing data disaggregated not only by sex but also by pregnancy status to accurately identify the risk factors associated with LP so that programs and policies can effectively and efficiently address LP in Brazil and beyond.

title: What's pregnancy got to do with it? Late presentation to XXXX / @entity791 services in Northeastern Brazil.

answer: @entity645 :: (57667,Species) :: ['HIV']


abstract: BACKGROUND: Development of de novo donor-specific antibodies (dnDSA) is associated with late or @entity102 ( @entity102 ) and poor graft outcome in low-risk kidney transplant recipients. High-level soluble @entity8410 (sBAFF) was observed in kidney recipients at higher risk of developing dnDSA. METHODS: We longitudinally analyzed sBAFF levels in 81 consecutive primary pediatric kidney recipients monitored for de novo human leukocyte antigen (HLA) antibody (Ab) occurrence to gain insight into the events conditioning B-cell activation posttransplant and to analyze the usefulness of paired DSA-sBAFF monitoring in this clinical setting. RESULTS: At a median follow-up of 65 months, 23 @entity1 (28%) developed dnDSA, with 13 of 23 developing @entity102 . Irrespective of HLA Ab status, sBAFF levels progressively increased in all @entity1 in the first posttransplant year, thereafter reaching a plateau. sBAFF levels were influenced by the degree of @entity1531 match and donor age. Despite higher levels of sBAFF in HLA Ab-positive @entity1 (median and 95% confidence interval sBAFF in DSA+non-DSA @entity1 : 568, 534-608 pg/mL vs. 502, 422-548 pg/mL in Ab-negative @entity1 ; P<0.05), we found that sBAFF monitoring could not predict DSA development by a time to event longitudinal analysis. Moreover, sBAFF kinetics up to @entity102 onset could not anticipate @entity102 development in the DSA cohort. CONCLUSION: Our findings provide evidence of early posttransplant B-cell activation even in unsensitized recipients of first kidney allograft. The significance of this activation, likely induced by exposition to the allograft, is yet unclear.

title: Posttransplant Soluble XXXX Kinetics in Pediatric Recipients of First Kidney Allograft.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['CAMR', 'chronic antibody-mediated rejection']

entities_list: @entity8410 :: ('10673', 'Gene') :: ['B-cell activating factor']

answer: @entity8410 :: (10673,Gene) :: ['B-Cell Activating Factor']


abstract: UNASSIGNED: In the present paper, we focus on the age of onset for @entity2701 in a population-based sample in the Parma, distinguishing its different subtypes and considering definite and probable diagnoses. Age of @entity10 onset is a useful clinical feature for differential diagnosis between primary @entity10 and between primary and secondary @entity10 forms. A total of 904 subjects representative of the Parma's adult general population were interviewed face to face by a physician from the Parma @entity10 Centre, using a validated questionnaire specially designed for the diagnosis of primary @entity10 according to the @entity1605 . In the majority of subjects diagnosed with definite @entity2701 , age of onset was 39  years or less, while mean age of onset was 29.7  years (SD 16.3  years, range 5-79  years), the median being 25  years. Both infrequent and frequent episodic definite @entity2701 first occurred in the majority of cases in the second, third and fourth decades. Subjects with chronic definite @entity2701 reported a later onset in life (i.e. fourth, fifth and sixth decades). In our study, mean age of onset for probable @entity2701 was 23.7  years (SD 9.2  years, range 10-40  years) and the median was 22  years. In no case did we find significant gender differences. Our study results are similar to most of those reported in the literature. Further research needs to be done in the Italian epidemiological context, given the lack of literature reports on this topic.

title: XXXX in Parma's adult general population: a focus on age of onset.

entities_list: @entity2701 :: ('MESH:D018781', 'Disease') :: ['tension-type headache']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'headaches', 'Headache']

entities_list: @entity1605 :: ('OMIM:217000', 'Disease') :: ['ICHD-II criteria']

answer: @entity2701 :: (MESH:D018781,Disease) :: ['Tension-type headache']


abstract: A small hydrological basin (Lerma, NE Spain), transformed from its natural state (steppe) to rain-fed agriculture and recently to irrigation agriculture, has been monitored across four seasons of an agricultural year. The goal of this study was to assess how and whether agricultural activities impacted the nearby freshwater ecosystems via runoff. Specifically, we assessed the @entity137 of three @entity21750 herbicides, @entity24196 , @entity12472 and @entity14458 on the photosynthetic efficiency and structure of algal benthic biofilms (i.e., phototropic periphyton) in the small creek draining the basin. It was expected that the seasonal runoff of the herbicides in the creek affected the sensitivity of the periphyton in accord with the rationale of the Pollution Induced Community Tolerance (PICT): the exposure of the community to pollutants result in the replacement of sensitive species by more tolerant ones. In this way, PICT can serve to establish causal linkages between pollutants and the observed biological impacts. The periphyton presented significantly different sensitivities against @entity24196 through the year in accord with the seasonal application of this herbicide in the crops nowadays. The sensitivity of already banned herbicides, @entity12472 and @entity14458 does not display a @entity16488 . The different sensitivities to herbicides were in agreement with the expected exposures scenarios, according to the agricultural calendar, but not with the concentrations measured in water, which altogether indicates that the use of PICT approach may serve for long-term monitoring purposes. That will provide not only causal links between the occurrence of chemicals and their impacts on natural communities, but also information about the occurrence of chemicals that may escape from traditional sampling methods (water analysis). In addition, the EC50 and EC10 of periphyton for @entity24196 or @entity14458 are the first to be published and can be used for impact assessments.

title: Impacts of agricultural irrigation on nearby freshwater ecosystems: The seasonal influence of XXXX herbicides in benthic algal communities.

entities_list: @entity16488 :: ('MESH:D018262', 'Disease') :: ['clear seasonality']

entities_list: @entity21750 :: ('CHEBI:38056', 'Chemical') :: ['triazine']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity24196 :: ('MESH:C037565', 'Chemical') :: ['terbuthylazine']

answer: @entity21750 :: (CHEBI:38056,Chemical) :: ['triazine']


abstract: BACKGROUND: Hazelnut @entity566 shows distinct clinical patterns that can be predicted through component-resolved diagnosis. However, identification of sensitization profiles remains incomplete. METHODS: Sera of 75 @entity1 @entity56 to hazelnuts, 14 @entity1 with @entity483 ( @entity483 ) sensitized to hazelnuts, 15 hazelnut-tolerant individuals with specific IgE (sIgE) to hazelnuts and 15 healthy control individuals were tested for sIgE reactivity to rCor a 1.04, rCor a 8, nCor a 9, nCor a 11, rCor a 14, rBet v 1, rBet v 2 and cross-reactive @entity1735 determinants (CCDs). RESULTS: Sensitization to Cor a 14 was observed in 18 out of 20 preschool @entity1 , 8 out of 10 school-aged @entity1 and 2 out of 7 adults with generalized reactions and in 3 out of 14 @entity1 with @entity483 . Only 2 out of 38 @entity1 with an @entity566 ( @entity566 ) were sensitized to Cor a 14. No sensitization to Cor a 14 was observed in the group of hazelnut-tolerant and healthy control individuals. Sensitization to Cor a 1.04 was seen in 36 out of 38 @entity566 @entity1 and in 14 out of 37 @entity1 with generalized reactions. However, only 3 @entity1 with generalized reactions were monosensitized to Cor a 1.04. Sensitization to Cor a 9 was observed in 26 out of 37 @entity1 with generalized reactions and in 4 out of 14 @entity1 with @entity483 . Sensitization to Cor a 11, Cor a 8, rBet v 2 and CCDs was rare. CONCLUSIONS: Sensitization to Cor a 14 can have early onset and shows age-related variations. Together with Cor a 9, Cor a 14 enables us to correctly identify almost 90% of @entity1 with generalized reactions to hazelnut.    2014 S. Karger AG, Basel.

title: Cor a 14: missing link in the molecular diagnosis of hazelnut XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'infants']

entities_list: @entity483 :: ('MESH:D003876', 'Disease') :: ['atopic dermatitis', 'AD']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['OAS', 'allergy', 'oral allergy syndrome']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic']

answer: @entity566 :: (MESH:D006967,Disease) :: ['allergy']


abstract: BACKGROUND: The aim of the present study was to assess whether @entity130 is a risk determinant for knee and @entity3681 ( @entity571 ) in former professional football players and to explore @entity571 -related activity and work limitations. METHODS: To retrieve the relevant recent literature, the Medline, Embase and Sportdiscus databases were systematically searched for studies published from January 2000 to May 2012. Included studies must be primary studies that are written in English, Dutch, French or German and involve former professional football players; injury had to be studied as an independent variable; and knee/ @entity3681 , work participation or limited activities had to be described as an outcome. The data from included studies were extracted using a standardised extraction form, and the methodological quality was assessed. RESULTS: No studies were retrieved about injury as a risk determinant for knee/ @entity3681 in former professional football players. Four studies about @entity571 -related activity and work limitations were included (three of high and one of moderate methodological quality). Up to 17% of former professional football players with knee/ @entity3681 reported suffering from @entity158 and discomfort during activities such as squatting, walking and climbing stairs. Former professional football players with knee/ @entity3681 reported that their conditions were very @entity158 , chronically @entity158 and affected their daily lives, while 28% reported work-related limitations. CONCLUSION: Knee and @entity3681 in former professional football players causes @entity158 and discomfort that has negative consequences for daily life and work activities. An @entity571 health examination programs should be developed to empower the sustainable health and functioning of professional football players.

title: Risk and consequences of XXXX after a professional football career: a systematic review of the recent literature.

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['joint pain', 'painful']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['previous injury']

entities_list: @entity3681 :: ('MESH:D016512', 'Disease') :: ['ankle OA', 'ankle osteoarthritis']

answer: @entity571 :: (MESH:D010003,Disease) :: ['osteoarthritis']


abstract: INTRODUCTION: Accurate, continuous, left @entity64 (SV) measurements can convey large amounts of information about @entity1 hemodynamic status and response to therapy. However, direct measurements are highly invasive in clinical practice, and current procedures for estimating SV require specialized devices and significant approximation. METHOD: This study investigates the accuracy of a three element Windkessel model combined with an aortic pressure waveform to estimate SV. Aortic pressure is separated into two components capturing; 1) resistance and compliance, 2) characteristic impedance. This separation provides model-element relationships enabling SV to be estimated while requiring only one of the three element values to be known or estimated. Beat-to-beat SV estimation was performed using population-representative optimal values for each model element. This method was validated using measured SV data from porcine experiments (N=3 female Pietrain @entity1707 , 29-37 kg) in which both ventricular volume and aortic pressure waveforms were measured simultaneously. RESULTS: The median difference between measured SV from left ventricle (LV) output and estimated SV was 0.6 ml with a 90% range (5th-95th percentile) -12.4 ml-14.3 ml. During periods when changes in SV were induced, cross correlations in between estimated and measured SV were above R=0.65 for all cases. CONCLUSION: The method presented demonstrates that the magnitude and trends of SV can be accurately estimated from pressure waveforms alone, without the need for identification of complex physiological metrics where strength of correlations may vary significantly from @entity1 to @entity1 .

title: Continuous XXXX volume estimation from aortic pressure using zero dimensional cardiovascular model: proof of concept study from porcine experiments.

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['ventricular stroke volume']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: INTRODUCTION: Currently there is little information on the effects of prolactin (PRL) on the coagulation and fibrinolytic systems. OBJECTIVE: The aim of this study was to evaluate the effects of hypeprolactinemia on the parameters of the hemostatic system and activation of the coagulation system. METHODS: We studied PRL levels, body mass index (BMI), values of activated partial thromboplastin time (aPTT), prothrombin time (PT), @entity556 time (TT), D-dimer level, @entity2880 factor antigen (vWFAg) and fibrinogen in 15 young female @entity1 with @entity2013 before and after therapy and in 15 healthy female controls. RESULTS: As expected, pretreatment PRL levels were significantly higher in @entity1 than in controls (140.90 +/- 42.87 vs. 12.53 +/- 4.05 ng/ml; p < 0.001). PT, although still in the normal range, was prolonged in @entity1 with @entity4089 as compared to the control group (13.53 +/- 1.39 vs. 12.65 +/- 0.53 s; p = 0.03) and normalized after therapy (12.69 +/- 0.65 vs. 12.65 +/- 0.53 s; p = 0.88). TT, although in normal range, was significantly shorter in the hypeprolactinemic @entity1 than in the controls (14.34 +/- 4.52 vs. 17.21 +/- 1.35 s; p < 0.025) and after treatment remained significantly shorter than in the controls (15.17 +/- 1.55 vs. 17.21 +/- 1.35 s; p < 0.0001). D-dimer values before treatment in the @entity1 with hyperproplactinemia were above the normal range (239.47 +/- 107.93 vs. 131.27 +/- 50.64 ng/ml, p = 0.002) and decreased to normal values after therapy (239.47 +/- 107.93 vs. 146.60 +/- 39.15 ng/ml; p < 0.001). D-dimer levels correlated with PRL (r = 0.30) and the change in serum D-dimer values significantly correlated with the change in PRL levels during therapy (r = 0.62). aPTT, vWFAg and fibrinogen were similar in @entity1 and controls. CONCLUSION: In our study, increased @entity556 generation that resulted in elevated D-dimer levels may be one of the contributing factors to the prethrombotic state in @entity1 with @entity4089 .

title: The influence of @entity4089 on coagulation parameters in females with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4089 :: ('MESH:D006966', 'Disease') :: ['hyperprolactinemia']

entities_list: @entity2013 :: ('MESH:D015175', 'Disease') :: ['microprolactinomas']

entities_list: @entity2880 :: ('MESH:D014842', 'Disease') :: ['von Willebrand']

answer: @entity2013 :: (MESH:D015175,Disease) :: ['prolactinomas']


abstract: INTRODUCTION: Currently there is little information on the effects of prolactin (PRL) on the coagulation and fibrinolytic systems. OBJECTIVE: The aim of this study was to evaluate the effects of hypeprolactinemia on the parameters of the hemostatic system and activation of the coagulation system. METHODS: We studied PRL levels, body mass index (BMI), values of activated partial thromboplastin time (aPTT), prothrombin time (PT), @entity556 time (TT), D-dimer level, @entity2880 factor antigen (vWFAg) and fibrinogen in 15 young female @entity1 with @entity2013 before and after therapy and in 15 healthy female controls. RESULTS: As expected, pretreatment PRL levels were significantly higher in @entity1 than in controls (140.90 +/- 42.87 vs. 12.53 +/- 4.05 ng/ml; p < 0.001). PT, although still in the normal range, was prolonged in @entity1 with @entity4089 as compared to the control group (13.53 +/- 1.39 vs. 12.65 +/- 0.53 s; p = 0.03) and normalized after therapy (12.69 +/- 0.65 vs. 12.65 +/- 0.53 s; p = 0.88). TT, although in normal range, was significantly shorter in the hypeprolactinemic @entity1 than in the controls (14.34 +/- 4.52 vs. 17.21 +/- 1.35 s; p < 0.025) and after treatment remained significantly shorter than in the controls (15.17 +/- 1.55 vs. 17.21 +/- 1.35 s; p < 0.0001). D-dimer values before treatment in the @entity1 with hyperproplactinemia were above the normal range (239.47 +/- 107.93 vs. 131.27 +/- 50.64 ng/ml, p = 0.002) and decreased to normal values after therapy (239.47 +/- 107.93 vs. 146.60 +/- 39.15 ng/ml; p < 0.001). D-dimer levels correlated with PRL (r = 0.30) and the change in serum D-dimer values significantly correlated with the change in PRL levels during therapy (r = 0.62). aPTT, vWFAg and fibrinogen were similar in @entity1 and controls. CONCLUSION: In our study, increased @entity556 generation that resulted in elevated D-dimer levels may be one of the contributing factors to the prethrombotic state in @entity1 with @entity4089 .

title: The influence of XXXX on coagulation parameters in females with @entity2013 .

answer: @entity4089 :: (MESH:D006966,Disease) :: ['hyperprolactinemia']


abstract: OBJECTIVES: To correlate pharmacokinetic parameters of 3-T dynamic contrast-enhanced (DCE-)MRI with histopathologic microvascular and lymphatic parameters in organ-confined @entity263 . METHODS: In 18 @entity1 with unilateral peripheral zone (pT2a) @entity5 who underwent DCE-MRI prior to radical prostatectomy (RP), the following pharmacokinetic parameters were assessed: permeability surface area volume transfer constant (K (trans)), extravascular extracellular volume (Ve) and rate constant (K ep). In the RP sections blood and lymph vessels were visualised immunohistochemically and automatically examined and analysed. Parameters assessed included microvessel density (MVD), area (MVA) and perimeter ( @entity27810 ) as well as lymph vessel density (LVD), area (LVA) and perimeter (LVP). RESULTS: A negative correlation was found between age and K (trans) and K ep for @entity5 (r   =   -0.60, p   =   0.009; r   =   -0.67, p   =   0.002) and normal (r   =   -0.54, p   =   0.021; r   =   -0.46, p   =   0.055) tissue. No correlation existed between absolute values of microvascular parameters from histopathology and DCE-MRI. In contrast, the ratio between @entity5 and normal tissue (correcting for individual microvascularity variations) significantly correlated between K ep and MVD (r   =   0.61, p   =   0.007) and @entity27810 (r   =   0.54, p   =   0.022). The lymphovascular parameters showed only a correlation between LVA and K ep (r   =   -0.66, p   =   0.003). CONCLUSIONS: Significant correlations between DCE-MRI and histopathologic parameters were found when correcting for interpatient variations in microvascularity. KEY POINTS:     Normal prostate tissue shows strong heterogeneity in microvascularity.     @entity263 shows increased and less heterogeneous microvascularity.     Normal and @entity5 tissue shows considerable variation in microvascularity between @entity1 .     DCE-MRI should take into account the interprostatic heterogeneity of microvasculature between @entity1 .

title: Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined XXXX .

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'Peripheral zone prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: We studied the effect of @entity208 on the prevention of stone recurrence in 134 @entity1 with recurrent, idiopathic @entity460 @entity1790 . They consisted of 113 male @entity1 and 21 female, between 16 and 72 years with an average age of 42.7. The @entity1 were divided into two groups according to the type of stone occurrence; those with multiple stones without previous stone episodes (multiple stone group), and the those with recurrent stones (stone episode group). Twenty three @entity1 belonged to the multiple stone group and 111 @entity1 belonged to the stone episode group. The stones in 19 of the 23 @entity1 in the multiple stone group remained stable throughout the study, while stones in 4 grew. Fifty-nine of the 111 @entity1 in the stone episode group were free from recurrence, but the others showed recurrence. Statistical analyses was done on the stone episode group. The stone recurrence rate of all of the 111 cases showed significant decrease during prophylactic treatment with @entity208 (p less than 0.01), although the observation period before treatment was 73.0 +/- 65.8 months and that during and after treatment was 28.2 +/- 12.1 months. During the two years before and after prophylaxis 79 @entity1 also showed a significantly decreased recurrence rate. Moreover, regarding 37 cases without any stones at the start of treatment, stone recurrence rate decreased significantly after the administration of @entity208 . Throughout this study, we used a new method for evaluating reasonable stone recurrence. It did not calculate the number of stones recurred, but the stone-forming circumstance in each kidney.(ABSTRACT TRUNCATED AT 250 WORDS)

title: [A study of XXXX in the prevention of recurrent calcium oxalate stones].

entities_list: @entity1790 :: ('MESH:D053040', 'Disease') :: ['nephrolithiasis']

entities_list: @entity208 :: ('MESH:D000493', 'Chemical') :: ['allopurinol']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity208 :: (MESH:D000493,Chemical) :: ['allopurinol']


abstract: Physiological correlates of @entity146 , substance use onset and initiation of risky sexual behavior have not been studied in adolescents with prenatal drug exposure. We studied the concordance between baseline @entity13610 ( @entity13610 ) at age 3 and baseline @entity701 levels at age 11. We hypothesized that @entity1 who showed concordance between @entity13610 and @entity701 would have @entity4934 scores which would in turn predict age of substance use onset and first sexual intercourse. The sample included 860 @entity1 aged 16 years participating in the Maternal Lifestyle Study, a multisite longitudinal study of @entity1 with prenatal exposure to @entity2072 and other substances. Structural equation modeling was used to test pathways between prenatal substance exposure, early adversity, baseline @entity13610 , baseline @entity701 , @entity4934 , drug use, and sexual behavior outcomes. Concordance was studied by examining separate male and female models in which there were statistically significant interactions between baseline @entity13610 and @entity701 . Prenatal substance exposure was operationalized as the number of substances to which the @entity1 was exposed. An adversity score was computed based on caregiver postnatal substance use, @entity308 and @entity458 , number of caregiver changes, socioeconomic and poverty status, quality of the home environment, and @entity1 history of protective service involvement, abuse and neglect. @entity13610 and @entity701 were measured during a baseline period prior to the beginning of a task. @entity4934 , based on composite scores of @entity146 and @entity409 , substance use and sexual behavior were derived from questionnaires and cognitive tests administered to the @entity1 . Findings were sex specific. In females, those with discordance between @entity13610 and @entity701 (high @entity13610 and low @entity701 or low @entity13610 and high @entity701 ) had the most @entity409 which, in turn, predicted earlier initiation of @entity285 by age 16. Among @entity1 , there also existed a significant baseline @entity13610 by baseline @entity701 interaction. @entity1 with low baseline @entity13610 and high baseline @entity701 had the highest levels of @entity146 . This @entity146 was in turn related to initiation of @entity285 use by age 16 and lower age of first sexual intercourse. We found sex-specific pathways to the initiation of @entity285 use and risky sexual behavior through the combined activity of parasympathetic and neuroendocrine functioning. The study of multiple physiological systems may suggest new pathways to the study of age of onset of substance use and engagement in risky sexual behavior in adolescents.

title: Physiological correlates of XXXX that relate to drug use and risky sexual behavior in adolescents with prenatal substance exposure.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Boys', 'boys', 'child']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral dysregulation', 'behavioral and emotional problems', 'increase in behavioral dysregulation']

entities_list: @entity13610 :: ('MESH:D001146', 'Disease') :: ['RSA', 'respiratory sinus arrhythmia']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['executive dysfunction']

entities_list: @entity4934 :: ('MESH:D019954', 'Disease') :: ['Neurobehavioral disinhibition', 'neurobehavioral disinhibition', 'lower neurobehavioral disinhibition']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

answer: @entity4934 :: (MESH:D019954,Disease) :: ['neurobehavioral disinhibition']


abstract: BACKGROUND: Non-coding RNAs (ncRNAs) are emerging as key regulators of many cellular processes in both physiological and pathological states. Moreover, the constant discovery of new non-coding RNA species suggests that the study of their complex functions is still in its very early stages. This variegated class of RNA species encompasses the well-known microRNAs (miRNAs) and the most recently acknowledged long non-coding RNAs (lncRNAs). Interestingly, in the last couple of years, a few studies have shown that some lncRNAs can act as miRNA sponges, i.e. as competing endogenous RNAs (ceRNAs), able to reduce the amount of miRNAs available to target messenger RNAs (mRNAs). RESULTS: We propose a computational approach to explore the ability of lncRNAs to act as ceRNAs by protecting mRNAs from miRNA repression. A seed match analysis was performed to validate the underlying regression model. We built normal and @entity5 networks of miRNA-mediated sponge interactions (MMI-networks) using @entity0 expression data provided by The Cancer Genome Atlas. CONCLUSIONS: Our study highlights a marked rewiring in the ceRNA program between normal and pathological breast tissue, documented by its "on/off" switch from normal to @entity5 , and vice-versa. This mutually exclusive activation confers an interesting character to ceRNAs as potential oncosuppressive, or oncogenic, protagonists in @entity5 . At the heart of this phenomenon is the lncRNA @entity38550 , as illustrated by both the width of its antagonist mRNAs in normal-MMI-network, and the relevance of the latter in @entity0 . Interestingly, @entity38550 revealed a net binding preference towards the mir-200 family as the bone of contention with its rival mRNAs.

title: Computational analysis identifies a sponge interaction network between long non-coding RNAs and messenger RNAs in human XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: BACKGROUND: @entity102 , such as @entity740 ( @entity740 ), are growing in incidence and prevalence, in part due to an aging population. Support provided through home care services may be useful in attaining a more efficient and higher quality care for @entity740 @entity1 . METHODS: A systematic review was performed to identify studies examining home care interventions among adult @entity740 @entity1 incorporating all outcomes. Studies examining home care services as an alternative to acute, post-acute or hospice care and those for long-term maintenance in @entity1 ' homes were included. Studies with only a home training intervention and those without an applied research component were excluded. RESULTS: Seventeen studies (10 cohort, 4 non-comparative, 2 cross-sectional, 1 randomized) examined the support provided by home care services in 15,058 @entity740 @entity1 . Fourteen studies included @entity298 ( @entity298 ), two incorporated hemodialysis (HD) and one included both @entity298 and HD @entity1 in their treatment groups. Sixteen studies focused on the dialysis phase of care in their study samples and one study included information from both the dialysis and pre-dialysis phases of care. Study settings included nine single hospital/dialysis centers and three regional/metropolitan areas and five were at the national level. Studies primarily focused on nurse assisted home care @entity1 and mostly examined @entity298 related clinical outcomes. In @entity298 studies with comparators, @entity298 risks and technique survival rates were similar across home care assisted @entity1 and comparators. The risk of mortality, however, was higher for home care assisted @entity298 @entity1 . While most studies adjusted for age and comorbidities, information about multidimensional prognostic indices that take into account physical, psychological, cognitive, functional and social factors among @entity740 @entity1 was not easily available. CONCLUSIONS: Most studies focused on nurse assisted home care @entity1 on dialysis. The majority were single site studies incorporating small @entity1 populations. There are gaps in the literature regarding the utility of providing home care to @entity740 @entity1 and the impact this has on healthcare resources.

title: XXXX and support provided by home care services: a systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['peritoneal dialysis', 'PD', 'peritonitis']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['Chronic diseases']

answer: @entity740 :: (MESH:D051436,Disease) :: ['Chronic kidney disease']


abstract: Fibronectin is a large, adhesive glycoprotein, also called opsonic alpha 2 surface-binding glycoprotein. This glycoprotein which participates in all adhesions may modulate wound healing; plasma fibronectin, because it is opsonically active, may mediate reticulo-endothelial activity. Citrated plasma samples were analysed from twenty surgical @entity1 with @entity5 . The samples were obtained preoperatively and on 1st, 3rd, 7th, 14th and 28th postoperative days. Fibronectin assay was made by laser immunonephelometry. Other samples were obtained from a population of 340 healthy male and female subjects whose age ranged from 10 to 70 years, so that reference could be made to the standard mean of fibronectin related to the age of each @entity1 . In the surgical @entity1 , there was a significant decrease in fibronectin from the first to the third postoperative day. On the 7th day, there was a secondary increase of fibronectin levels which exceeded the preoperative values at the 14th and 28th days. There was no plasma dilution when the samples were collected, this being shown by protidaemia, osmolarity and haematocrit which were measured at the same time. "Septic" and "non septic" @entity1 were compared. For septic @entity1 , fibronectin levels were lower and the secondary increase occurred later than in the non septic @entity1 . @entity1 with no secondary increase did not recover and died. Fibronectin levels were compared with other classical parameters of nutritional assessment, i.e. @entity2313 , prealbumin, @entity69 and urinary @entity1011 indexes. These parameters were not well correlated. However, this study may indicate the usefulness of fibronectin as an indicator of nutritional status and of non specific host defence.

title: [Changes in levels of plasma fibronectin after surgery for XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['digestive cancer']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

answer: @entity5 :: (MESH:D009369,Disease) :: ['digestive cancer']


abstract: In this study, we performed a complete histologic analysis of constructs based on large diameter (   >100  m) @entity7049 ( @entity15274 ) microfibers obtained via dry-wet spinning and @entity35 Mesenchymal Stromal Cells (rMSCs) differentiated towards the osteogenic lineage, using acrylic resin embedding. In many synthetic polymer-based microfiber meshes, ex post processability of fiber/cell constructs for histologic analysis may face deterring difficulties, leading to an incomplete investigation of the potential of these scaffolds. Indeed, while polymeric nanofiber (fiber diameter = tens of nanometers)/cell constructs can usually be embedded in common histologic media and easily sectioned, preserving the material structure and the antigenic reactivity, histologic analysis of large polymeric microfiber/cell constructs in the literature is really scant. This affects microfiber scaffolds based on FDA-approved and widely used polymers such as @entity15274 and its copolymers. Indeed, for such constructs, especially those with fiber diameter and fiber interspace much larger than cell size, standard histologic processing is usually inefficient due to @entity3358 and lack of cohesion between the synthetic and the biological phases under sectioning. In this study, the microfiber/MSC constructs were embedded in acrylic resin and the staining/reaction procedures were calibrated to demonstrate the possibility of successfully employing histologic methods in tissue engineering studies even in such difficult cases. We histologically investigated the main osteogenic markers and extracellular matrix molecules, such as alkaline phosphatase, osteopontin, @entity9356 , @entity1810 , @entity6037 , Collagen type I and the presence of amorphous, fibrillar and mineralized matrix. Biochemical tests were employed to confirm our findings. This protocol permitted efficient sectioning of the treated constructs and good penetration of the histologic reagents, thus allowing distribution and expression of almost all the tested molecules to be revealed. Our results demonstrated that it is possible to perform histologic analyses of large-diameter @entity15274 -based microfiber scaffold/MSC constructs that face the failure of standard histologic procedures.

title: Processing large-diameter XXXX microfiber mesh/mesenchymal stromal cell constructs via resin embedding: an efficient histologic method.

entities_list: @entity3358 :: ('MESH:D018804', 'Disease') :: ['inhomogeneous hardness']

entities_list: @entity7049 :: ('MESH:C010506', 'Chemical') :: ['poly-L-lactic acid']

answer: @entity7049 :: (MESH:C010506,Chemical) :: ['poly(L-lactic acid)']


abstract: OBJECTIVE: The aim of the study was to evaluate laser-assisted fluorescent-dye angiography (LAA) to assess perfusion in the gastric graft and to correlate perfusion with subsequent @entity834 . BACKGROUND: @entity834 are a major source of morbidity after esophagectomy with gastric pull-up (GPU). In large part, they occur as a consequence of poor perfusion in the gastric graft. METHODS: Real-time intraoperative perfusion was assessed using LAA before bringing the graft up through the mediastinum. When there was a transition from rapid and bright to slow and less robust perfusion, this site was marked with a suture. The location of the @entity254 relative to the suture was noted and the outcome of the @entity254 ascertained by retrospective record review. RESULTS: Intraoperative LAA was used to assess graft perfusion in 150 consecutive @entity1 undergoing esophagectomy with planned GPU reconstruction. An esophagogastric @entity254 was performed in 144 @entity1 . A leak was found in 24 @entity1 (16.7%) and were significantly less likely when the @entity254 was placed in an area of good perfusion compared with when the @entity254 was placed in an area of less robust perfusion by LAA (2% vs 45%, P < 0.0001). By multivariate analysis perfusion at the site of the @entity254 was the only significant factor associated with a leak. CONCLUSIONS: Intraoperative real-time assessment of perfusion with LAA correlated with the likelihood of an @entity834 and confirmed the critical relationship between good perfusion and anastomotic healing. The use of LAA may contribute to reduced anastomotic morbidity.

title: Intraoperative Assessment of Perfusion of the Gastric Graft and Correlation With XXXX After Esophagectomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['Anastomotic leaks', 'anastomotic leak']

answer: @entity834 :: (MESH:D057868,Disease) :: ['Anastomotic Leaks']


abstract: @entity1 -controlled analgesia (PCA, intravenous self-application of narcotics) was studied during the early postoperative period. Subjects were 40 ASA I-III @entity1 recovering from elective major and minor surgery (each 20 having undergone abdominal or orthopaedic operations). @entity12586 bolusses of each 8 mg were available via a hand-button whenever the @entity1 felt @entity158 relief necessary, and delivered by a microprocessor-controlled injection pump (On-Demand Analgesia Computer, ODAC). Hourly maximum dose was set to 60 mg with a pump refractory time of 1 min between valid demands. A continuous low-dose @entity12586 infusion (1 mg/h) was additionally administered in order to prevent @entity3885 . Duration of the PCA period was 20.3 +/- 5.9 h (mean, standard deviation). During this time, 20.0 +/- 12.7 demands per @entity1 were recorded resulting in mean @entity12586 consumption of 135.6 +/- 81.4 micrograms/kg/h. Self-administration was characterized by considerable intra- and interindividual variability. There were no statistically significant differences with regard of @entity12586 consumption or @entity158 relief between abdominal and orthopaedic @entity1 , nor could any be demonstrated between the sexes. Similarly, no clear differences were found after various anaesthetic techniques (neuroleptanalgesia, @entity1508 or spinal anaesthesia). Over-all efficacy and @entity1 acceptance proved to be excellent. Effectiveness of PCA was judged superior by about 68% of @entity1 when compared with previously experienced conventional postoperative analgesia. Side effects ( @entity390 , emesis, sweating) occurred in about 10-18% but were usually of minor intensity. Circulatory or respiratory problems were not observed during the PCA period. @entity1 -controlled analgesia is discussed as a promising concept for the treatment of acute @entity158 and clinical @entity158 research.

title: [Postoperative on-demand analgesia with XXXX (Fortral)].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity12586 :: ('MESH:D010423', 'Chemical') :: ['pentazocine', 'Pentazocine']

entities_list: @entity1508 :: ('MESH:D006221', 'Chemical') :: ['halothane']

entities_list: @entity3885 :: ('MESH:D008173', 'Disease') :: ['catheter obstruction']

answer: @entity12586 :: (MESH:D010423,Chemical) :: ['pentazocine']


abstract: UNASSIGNED: We aimed to report environmental and blood lead level (BLL) in China, and investigate the relationship of BLL with body mass index (BMI) and @entity28 . 5558 subjects were enrolled from 16 sites in China. BLL was measured by atomic absorption spectrometry. Obesity was defined as BMI   >=    30   kg/m(2). Median (interquartile range) of BLL was 44.00    g/L (29.00-62.16) for @entity1 and 37.79    g/L (25.13-54.35) for @entity1 , about twice higher than in U.S. POPULATION: Subjects in rural and high-economic-status areas had significantly greater BLL (P   <   0.001). However, in these areas, the lead levels in drinking water, river water and @entity579 were comparable to or significantly lower than those in urban and low-economic-status areas. After adjustment for age, urbanization, economic status and metabolic factors, BLL was independently associated with BMI in @entity1 (P for trend   <   0.001), but not in @entity1 . In fully adjusted model, increased quartiles of BLL were associated with significantly increased odds ratios of @entity28 (P for trend   <   0.01) in @entity1 . In conclusion, BLLs in Chinese adults were much higher than in developed countries. There was a sex-specific association between BLL and BMI. Elevated BLL does not appear to be associated with lead levels in drinking water or @entity579 , suggesting some other exposure source.

title: Blood lead level and its association with body mass index and XXXX in China - Results from SPECT-China study.

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: OBJECTIVE: To evaluate the clinicopathological characteristics and the clinical outcome of @entity5 of the female reproductive tract. MATERIAL AND METHODS: @entity1 who were operated and diagnosed with synchronous @entity5 (n = 25) at the Dokuz Eylul University Department of Obstetrics and Gynecology Gynecologic Oncology Unit between 1992 and 2012 were included into this study. Recurrent, metastatic and metachronously detected @entity5 were not included. Age at diagnosis, parity menopausal status, hormone use, presenting sign or symptoms and the clinical outcomes were evaluated. RESULTS: 20 of 25 @entity1 had @entity43 . The mean age at diagnosis was 53,6 years. The most common presenting symptom was abnormal uterine @entity548 . The median follow-up duration for all @entity1 was 69 months. Overall survival for all @entity1 was 87 months and 81 months for @entity1 with @entity43 5-year survival rate was 73% for all @entity1 and 68% for @entity1 with @entity43 . CONCLUSIONS: @entity43 togetherness is the most common in synchronous gynecologic @entity5 . They occur at a younger age and have more favorable prognosis than metastatic primary gynecologic @entity5 .

title: XXXX of the female genital tract: a 20-year experience in a single center.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumor of the genital system', 'synchronous malignant neoplasms', 'malignancies', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Endometrial-ovarian cancer', 'endometrial-ovarian cancer']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Synchronous tumors']


abstract: INTRODUCTION: @entity46 is defined as the appearance of ectopic endometrial cells outside the uterine cavity. Ectopic cells demonstrate functional similarity to eutopic cells, but structural and molecular differences are significant and manifest themselves in gene expression of the metalloproteinase genes, integrin or the @entity588 gene. @entity2371 remains to be the main symptom of the disease. @entity46 may cause dysfunction of the reproductive system and lead to @entity249 . Pathogenesis of @entity249 in @entity46 is based on its influence on the hormonal, biochemical and immunological changes in the eutopic endometrium, as well as structural damages of the ovaries and the fallopian tubes. OBJECTIVES: The aim of the study was to assess the ovarian reserve in @entity1 with @entity46 . MATERIAL AND METHODS: A total of 39 @entity1 (aged 22-34 years) with different stages of endometrial changes were recruited for the study. The number of antral follicles was rated by vaginal ultrasonography and the level of FSH was measured between days 1-3 of the menstrual cycle. The stage of the disease was established after laparoscopy with the rASRM scale. RESULTS: No statistically significant correlation between the number of follicles (AFC), the level of FSH and the stage of @entity46 was found. CONCLUSIONS: Evaluation of the number of antral follicles and measurements of the FSH level do not allow to predict the ovarian reserve in @entity1 with @entity46 .

title: Ovarian reserve assessment in XXXX with different stages of pelvic endometriosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity2371 :: ('MESH:D017699', 'Disease') :: ['Pelvic pain']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['Endometriosis', 'endometriosis']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: OBJECTIVE: To compare the clinical therapeutic effects between @entity1787 and @entity2995 for the treatment of mild @entity130 . METHODS: From January 2008 to December 2012, 119 @entity1 with @entity130 diagnosed as type I or II by MRI were divided into three groups. In the @entity2995 (A) group, there were 38 males and 2 females, with an average age of (25.34 +/- 6.34) years old, ranging from 18 to 48 years old; 36 @entity1 had single knee injuries, 4 @entity1 had double knee injuries and 44 knees with @entity1143 . In the @entity1787 (B) group,there were 37 males and 2 females, with an average age of (26.98 +/- 7.20) years old, ranging from 19 to 50 years old; 33 @entity1 had single knee injuries, 6 patiens had double knees injuries and 40 knees with @entity1143 . In the combination of @entity1787 and @entity2995 (C) group, there were 37 males and 3 females,with an average age of (26.44 +/- 6.38) years old, ranging from 18 to 47 years old; 33 @entity1 had single knee injuries, 7 @entity1 had double knees injuries and 39 knees with @entity1143 . The @entity1 were treated with injection of 3 mg @entity2995 alone, 30 ml (30 microg/ml) @entity1787 alone, or both two drugs respectively in knee joint cavity. All the treatment methods were carried out weekly and 4 times injections were required for a treatment course. Knee joint function was evaluated by Lysholm scale and @entity1143 was examined by MRI before and after treatment. RESULTS: The scale of knee joint function was 35.68 +/- 4.15 and 65.55 +/- 7.66 in group A, 36.35 +/- 6.83 and 74.39 +/- 8.47 in group B, 36.62 +/- 6.03 and 95.47 +/- 4.78 in group C before and after treatment. Compared with that before treatment, the total scale of knee joint function improved after treatment in every group. The total scale of group C was better than that of the other groups after the treatment,but there was no significant difference between group A and group B. The effective rate of these @entity1143 was 68.18% in group A, 62.5% in group B and 87.18% in group C. The effect of co-injection on @entity1143 in group C was significantly better than that of @entity2995 or @entity1787 alone, but the difference between group A and group B was not significant. CONCLUSION: @entity1787 and @entity2995 are effective in the treatment of mild @entity130 , which can relieve symptoms and promote the recovery of joint function. Campared with the single injection, the combination of @entity1787 and @entity2995 is better.

title: [Case-control study on therapeutic effects of @entity1787 and XXXX on the treatment of @entity130 ].

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['knee joint effusion', 'joint effusion', 'drugson joint effusion']

entities_list: @entity2995 :: ('MESH:D014222', 'Chemical') :: ['triamcinolone acetonide']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['meniscal injury']

answer: @entity2995 :: (MESH:D014222,Chemical) :: ['triamcinolone acetonide']


abstract: OBJECTIVE: To compare the clinical therapeutic effects between @entity1787 and @entity2995 for the treatment of mild @entity130 . METHODS: From January 2008 to December 2012, 119 @entity1 with @entity130 diagnosed as type I or II by MRI were divided into three groups. In the @entity2995 (A) group, there were 38 males and 2 females, with an average age of (25.34 +/- 6.34) years old, ranging from 18 to 48 years old; 36 @entity1 had single knee injuries, 4 @entity1 had double knee injuries and 44 knees with @entity1143 . In the @entity1787 (B) group,there were 37 males and 2 females, with an average age of (26.98 +/- 7.20) years old, ranging from 19 to 50 years old; 33 @entity1 had single knee injuries, 6 patiens had double knees injuries and 40 knees with @entity1143 . In the combination of @entity1787 and @entity2995 (C) group, there were 37 males and 3 females,with an average age of (26.44 +/- 6.38) years old, ranging from 18 to 47 years old; 33 @entity1 had single knee injuries, 7 @entity1 had double knees injuries and 39 knees with @entity1143 . The @entity1 were treated with injection of 3 mg @entity2995 alone, 30 ml (30 microg/ml) @entity1787 alone, or both two drugs respectively in knee joint cavity. All the treatment methods were carried out weekly and 4 times injections were required for a treatment course. Knee joint function was evaluated by Lysholm scale and @entity1143 was examined by MRI before and after treatment. RESULTS: The scale of knee joint function was 35.68 +/- 4.15 and 65.55 +/- 7.66 in group A, 36.35 +/- 6.83 and 74.39 +/- 8.47 in group B, 36.62 +/- 6.03 and 95.47 +/- 4.78 in group C before and after treatment. Compared with that before treatment, the total scale of knee joint function improved after treatment in every group. The total scale of group C was better than that of the other groups after the treatment,but there was no significant difference between group A and group B. The effective rate of these @entity1143 was 68.18% in group A, 62.5% in group B and 87.18% in group C. The effect of co-injection on @entity1143 in group C was significantly better than that of @entity2995 or @entity1787 alone, but the difference between group A and group B was not significant. CONCLUSION: @entity1787 and @entity2995 are effective in the treatment of mild @entity130 , which can relieve symptoms and promote the recovery of joint function. Campared with the single injection, the combination of @entity1787 and @entity2995 is better.

title: [Case-control study on therapeutic effects of @entity1787 and @entity2995 on the treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity130 :: (MESH:D014947,Disease) :: ['meniscal injury']


abstract: OBJECTIVE: To compare the clinical therapeutic effects between @entity1787 and @entity2995 for the treatment of mild @entity130 . METHODS: From January 2008 to December 2012, 119 @entity1 with @entity130 diagnosed as type I or II by MRI were divided into three groups. In the @entity2995 (A) group, there were 38 males and 2 females, with an average age of (25.34 +/- 6.34) years old, ranging from 18 to 48 years old; 36 @entity1 had single knee injuries, 4 @entity1 had double knee injuries and 44 knees with @entity1143 . In the @entity1787 (B) group,there were 37 males and 2 females, with an average age of (26.98 +/- 7.20) years old, ranging from 19 to 50 years old; 33 @entity1 had single knee injuries, 6 patiens had double knees injuries and 40 knees with @entity1143 . In the combination of @entity1787 and @entity2995 (C) group, there were 37 males and 3 females,with an average age of (26.44 +/- 6.38) years old, ranging from 18 to 47 years old; 33 @entity1 had single knee injuries, 7 @entity1 had double knees injuries and 39 knees with @entity1143 . The @entity1 were treated with injection of 3 mg @entity2995 alone, 30 ml (30 microg/ml) @entity1787 alone, or both two drugs respectively in knee joint cavity. All the treatment methods were carried out weekly and 4 times injections were required for a treatment course. Knee joint function was evaluated by Lysholm scale and @entity1143 was examined by MRI before and after treatment. RESULTS: The scale of knee joint function was 35.68 +/- 4.15 and 65.55 +/- 7.66 in group A, 36.35 +/- 6.83 and 74.39 +/- 8.47 in group B, 36.62 +/- 6.03 and 95.47 +/- 4.78 in group C before and after treatment. Compared with that before treatment, the total scale of knee joint function improved after treatment in every group. The total scale of group C was better than that of the other groups after the treatment,but there was no significant difference between group A and group B. The effective rate of these @entity1143 was 68.18% in group A, 62.5% in group B and 87.18% in group C. The effect of co-injection on @entity1143 in group C was significantly better than that of @entity2995 or @entity1787 alone, but the difference between group A and group B was not significant. CONCLUSION: @entity1787 and @entity2995 are effective in the treatment of mild @entity130 , which can relieve symptoms and promote the recovery of joint function. Campared with the single injection, the combination of @entity1787 and @entity2995 is better.

title: [Case-control study on therapeutic effects of XXXX and @entity2995 on the treatment of @entity130 ].

answer: @entity1787 :: (MESH:D010126,Chemical) :: ['ozone']


abstract: PURPOSE: A biomarker for dietary @entity3096 intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of @entity3088 from these sources for the prevention of @entity102 . Urinary @entity35620 (HA)-a major metabolite of @entity3088 -is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV. METHODS: Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9-16  years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (n  =  192) and confirmation (n  =  95) of results. RESULTS: Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (r unadjusted  =  0.47, P  <  0.0001). Yet, 79  % of the subjects were classified into same/adjacent quartiles, and only 5  % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (r unadjusted  =  0.64; 88  % in same/adjacent vs. 4  % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples. CONCLUSIONS: BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.

title: Relative validation of 24-h urinary @entity35620 excretion as a biomarker for dietary XXXX intake from fruit and vegetables in healthy adolescents.

entities_list: @entity3088 :: ('MESH:D005419', 'Chemical') :: ['flavonoids']

entities_list: @entity3096 :: ('CHEBI:47916', 'Chemical') :: ['flavonoid']

entities_list: @entity35620 :: ('MESH:C030514', 'Chemical') :: ['hippuric acid']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases']

answer: @entity3096 :: (CHEBI:47916,Chemical) :: ['flavonoid']


abstract: PURPOSE: A biomarker for dietary @entity3096 intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of @entity3088 from these sources for the prevention of @entity102 . Urinary @entity35620 (HA)-a major metabolite of @entity3088 -is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV. METHODS: Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9-16  years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (n  =  192) and confirmation (n  =  95) of results. RESULTS: Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (r unadjusted  =  0.47, P  <  0.0001). Yet, 79  % of the subjects were classified into same/adjacent quartiles, and only 5  % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (r unadjusted  =  0.64; 88  % in same/adjacent vs. 4  % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples. CONCLUSIONS: BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.

title: Relative validation of 24-h urinary XXXX excretion as a biomarker for dietary @entity3096 intake from fruit and vegetables in healthy adolescents.

answer: @entity35620 :: (MESH:C030514,Chemical) :: ['hippuric acid']


abstract: BACKGROUND: @entity4998 ( @entity4998 ) are a heterogeneous group of rare @entity74 of sex determination or differentiation. Evidence-based guidelines concerning gender assignment and surgical and hormonal treatment are limited for many @entity4998 entities, and health care is highly fragmented across various sub-specialties and settings. A lack of informed consent, secrecy about the condition, shame, and @entity73 may affect satisfaction with care. OBJECTIVES: The main goal of this study was to describe satisfaction with care in individuals with @entity4998 and to identify factors associated with low satisfaction with care. METHODS/MAIN MEASURES: Using both biological (chromosomes) and social categories (sex of rearing), we classified @entity1 according to the nomenclature of the European Society for Pediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society (ESPE/LWPES) consensus statement. We used standardized measures to assess satisfaction with care (CSQ-8), health-related quality of life (SF-36), @entity1109 (BSI), and gender identity (FGI), in addition to self-constructed questionnaires probing experiences with health care and access to self-help groups. @entity1 : A total of 110 adults were recruited between January 2005 and December 2007 in four study centers in Germany, Austria, and German-speaking Switzerland. RESULTS: Reports of half the @entity1 scored below the cut-off indicating low quality of care. @entity1 with XX @entity4998 conditions and virilization (i.e., @entity774 ) reported the highest scores for satisfaction with care, and @entity1 with XY @entity4998 conditions and complete lack of @entity342 effects reported the lowest scores. Satisfaction with care was positively associated with indicators of psychological well-being. CONCLUSIONS: Satisfaction with care is lowest among @entity1 with the rarest conditions, highlighting the lack of evidence-based recommendations and the lack of coordination of care. Associations of satisfaction and well-being indicate the need to ensure access to mental health services.

title: Utilization of health care services and satisfaction with care in adults affected by XXXX ( @entity4998 ).

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Women', 'PARTICIPANTS']

entities_list: @entity4998 :: ('MESH:D012734', 'Disease') :: ['DSD', 'Disorders of sex development']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired sexual and psychosocial functioning']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['psychological symptoms']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic disorders']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity774 :: ('MESH:D000312', 'Disease') :: ['congenital adrenal hyperplasia']

answer: @entity4998 :: (MESH:D012734,Disease) :: ['disorders of sex development']


abstract: BACKGROUND: @entity4998 ( @entity4998 ) are a heterogeneous group of rare @entity74 of sex determination or differentiation. Evidence-based guidelines concerning gender assignment and surgical and hormonal treatment are limited for many @entity4998 entities, and health care is highly fragmented across various sub-specialties and settings. A lack of informed consent, secrecy about the condition, shame, and @entity73 may affect satisfaction with care. OBJECTIVES: The main goal of this study was to describe satisfaction with care in individuals with @entity4998 and to identify factors associated with low satisfaction with care. METHODS/MAIN MEASURES: Using both biological (chromosomes) and social categories (sex of rearing), we classified @entity1 according to the nomenclature of the European Society for Pediatric Endocrinology/Lawson Wilkins Pediatric Endocrine Society (ESPE/LWPES) consensus statement. We used standardized measures to assess satisfaction with care (CSQ-8), health-related quality of life (SF-36), @entity1109 (BSI), and gender identity (FGI), in addition to self-constructed questionnaires probing experiences with health care and access to self-help groups. @entity1 : A total of 110 adults were recruited between January 2005 and December 2007 in four study centers in Germany, Austria, and German-speaking Switzerland. RESULTS: Reports of half the @entity1 scored below the cut-off indicating low quality of care. @entity1 with XX @entity4998 conditions and virilization (i.e., @entity774 ) reported the highest scores for satisfaction with care, and @entity1 with XY @entity4998 conditions and complete lack of @entity342 effects reported the lowest scores. Satisfaction with care was positively associated with indicators of psychological well-being. CONCLUSIONS: Satisfaction with care is lowest among @entity1 with the rarest conditions, highlighting the lack of evidence-based recommendations and the lack of coordination of care. Associations of satisfaction and well-being indicate the need to ensure access to mental health services.

title: Utilization of health care services and satisfaction with care in adults affected by @entity4998 ( XXXX ).

answer: @entity4998 :: (MESH:D012734,Disease) :: ['DSD']


abstract: OBJECTIVE: To determine the frequency of @entity746 ( @entity746 ) plateaus and reversals in the Pooled Resource Open-Access @entity746 Clinical Trials (PRO-ACT) database. METHODS: We analyzed Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS) and ALSFRS-revised (ALSFRS-R) data from PRO-ACT @entity1 . The frequencies of @entity1 experiencing plateaus (periods where scores did not change) were calculated over 6-, 12-, and 18-month epochs. The percentage of @entity1 ever experiencing reversals (periods where scores improved) of different lengths were also calculated and plotted. RESULTS: Over 6 months, 25% of 3,132 @entity1 did not decline. Over 12 months, 16% of 2,105 @entity1 did not decline. Over 18 months, 7% of 1,218 @entity1 did not decline. Small @entity746 reversals were also common, especially over shorter follow-up intervals; 14% of 1,343 @entity1 had a 180-day interval where their ALSFRS-R slope was greater than zero. Fewer than 1% of @entity1 ever experienced improvements of 4 or more ALSFRS-R points lasting at least 12 months. CONCLUSION: @entity746 plateaus and small reversals are common, especially over brief intervals. In light of these data, stable disease, especially for a short period of time, should not be interpreted as an @entity746 treatment effect. Large sustained @entity746 reversals, on the other hand, are rare, potentially important, and warrant further study.

title: How common are XXXX plateaus and reversals?

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['amyotrophic lateral sclerosis', 'ALS']

answer: @entity746 :: (MESH:D000690,Disease) :: ['ALS']


abstract: AIMS: To describe the characteristics of @entity66 ( @entity66 ) in @entity1 treated in a paediatric emergency department and to detect clinical differences, depending on whether the condition was ischaemic or @entity548 . @entity1 AND METHODS: An analytical, observation-based, retrospective study was conducted in the paediatric emergency department of a tertiary care hospital. The sample included @entity1 aged between 1 month and 18 years who were treated in the service over a period of 10 years (January 2001 to December 2011) with a final diagnosis of @entity66 . @entity548 due to @entity130 or secondary to @entity5 , @entity715 of the venous sinuses and @entity1 who were not treated in the service were all excluded. RESULTS: The final sample consisted of 61 @entity1 , 39 (63.9%) of whom were males, with a mean age of 4.6 years (range: 1.3 months-17.5 years). Of them, 26 (42.6%) presented @entity66 and 35 (57.4%) had @entity548 . @entity10 (n = 20; 57.1%; p = 0.008) and @entity391 (n = 25; 71.4%; p = 0.001) are more frequent in @entity548 , and @entity1269 (n = 17; 65.4%; p < 0.001) and @entity3541 (n = 7; 26.9%; p = 0.001) in @entity66 . The main causes of @entity548 are @entity2758 (n = 17; 38.6%) and the ischaemic ones are triggered by arteriopathies (n = 6; 42.3%). On discharge from hospital, 27 (44.3%) presented @entity717 and 6 (9.8%) died. CONCLUSIONS: @entity66 is a rare entity, although it presents a high morbidity and mortality rate. @entity548 is seen to predominate slightly and it is observed how @entity548 presents more often with signs of @entity428 , while the ischaemic form tends to have more neurological focus.

title: [Stroke in XXXX . Experience in an emergency service].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['different degrees of disability']

entities_list: @entity2758 :: ('MESH:D001165', 'Disease') :: ['arteriovenous malformations']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['CVD', 'cerebrovascular disease', 'ischaemic CVD']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhagic CVD', 'Haemorrhages', 'Haemorrhagic CVD', 'haemorrhagic']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['intracranial hypertension']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity3541 :: ('MESH:D005158', 'Disease') :: ['facial palsy']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: Only a minor proportion of @entity1 with acute @entity385 receive treatment with intravenous thrombolysis. The purpose of this study was to explore reasons for not giving thrombolysis and to determine if there was a correlation between prehospital and in-hospital delay in a Norwegian @entity385 . @entity1 with acute @entity385 were included during a 1-year period. Time intervals for prehospital and in-hospital delay, reasons for not treating with thrombolytic therapy in @entity1 admitted within the time window and reasons for late arrival were recorded. In all, 290 @entity1 were included, and 7.6  % were treated with intravenous thrombolysis. The most frequent reasons for not treating eligible @entity1 were: minor symptoms (22.8  %), clinical improvement (17.5  %) and uncertainty about the diagnosis (12.3  %). @entity1 ' reasons for delayed admission were: not attributing their symptoms to @entity64 (25.4  %), a wait-and-see attitude (25.4  %), and choosing to wait for the GP's office to open (14.3  %). Prehospital delay was strongly correlated to in-hospital delay (p  <  0.001). In conclusion, a large percentage of @entity1 with @entity1984 are not treated with thrombolysis because of mild or rapidly improving symptoms, and because @entity1 arrive too late to the hospital. Absolute and relative contraindications account for a minor proportion of reasons for excluding @entity1 .

title: Reasons for low thrombolysis rate in a Norwegian XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke', 'ischemic stroke population']

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke population']


abstract: UNASSIGNED: @entity3814 ( @entity3814 ) cause @entity158 and decreased physical ability, with no known well-established treatment. The aim of this study was to illuminate the experience of living with a @entity3814 . The results show that fear and concerns are a major part of daily life. The @entity1 's initial contact with health-care providers should focus on making them feel acknowledged by offering @entity1 -centered and tailored support. INTRODUCTION: In the past decade, @entity3604 have become an increasingly common and costly public health problem worldwide. @entity3814 ( @entity3814 ) is the second most common @entity3604 , and @entity1 with @entity3814 describe an abrupt descent into disability, with a subsequent desire to regain independence in everyday life; however, little is known of their situation. The aim of this study was to illuminate the lived experience of @entity1 with an @entity3814 . METHODS: Ten @entity1 were interviewed during 2012-2013, starting with an open-ended question: could you tell me what it is like to live with a vertebral compression @entity174 ? The verbatim transcribed interviews were analyzed using a phenomenological hermeneutical approach. RESULTS: The narrative provided descriptions of living in turmoil and chaos, unable to find stability in their life with little improvement regarding @entity158 and physical function. Shifts from periods of @entity158 to periods of fear of @entity158 created a loss of confidence and an increased sense of confinement. The structural analysis revealed fear and concerns as the most prominent experience building on five themes: struggling to understand a deceiving body, @entity158 fueling fear, fearing a trajectory into isolation, concerns of dependency, and fearing an uncertain future. CONCLUSIONS: Until researchers find a successful prevention or medical/surgical treatment for @entity3604 , health-care providers and society abandon these @entity1 to remain in a @entity158 and never ending story.

title: A XXXX , never ending story: older @entity1 's experiences of living with an osteoporotic vertebral compression @entity174 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'person']

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture', 'osteoporotic-related fractures', 'osteoporotic VCFs']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity3814 :: ('MESH:D050815', 'Disease') :: ['Vertebral compression fracture', 'osteoporotic VCF', 'VCF', 'Vertebral compression fractures']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['breakthrough pain', 'pain', 'constant pain', 'painful']

answer: @entity158 :: (MESH:D010146,Disease) :: ['painful']


abstract: UNASSIGNED: @entity3814 ( @entity3814 ) cause @entity158 and decreased physical ability, with no known well-established treatment. The aim of this study was to illuminate the experience of living with a @entity3814 . The results show that fear and concerns are a major part of daily life. The @entity1 's initial contact with health-care providers should focus on making them feel acknowledged by offering @entity1 -centered and tailored support. INTRODUCTION: In the past decade, @entity3604 have become an increasingly common and costly public health problem worldwide. @entity3814 ( @entity3814 ) is the second most common @entity3604 , and @entity1 with @entity3814 describe an abrupt descent into disability, with a subsequent desire to regain independence in everyday life; however, little is known of their situation. The aim of this study was to illuminate the lived experience of @entity1 with an @entity3814 . METHODS: Ten @entity1 were interviewed during 2012-2013, starting with an open-ended question: could you tell me what it is like to live with a vertebral compression @entity174 ? The verbatim transcribed interviews were analyzed using a phenomenological hermeneutical approach. RESULTS: The narrative provided descriptions of living in turmoil and chaos, unable to find stability in their life with little improvement regarding @entity158 and physical function. Shifts from periods of @entity158 to periods of fear of @entity158 created a loss of confidence and an increased sense of confinement. The structural analysis revealed fear and concerns as the most prominent experience building on five themes: struggling to understand a deceiving body, @entity158 fueling fear, fearing a trajectory into isolation, concerns of dependency, and fearing an uncertain future. CONCLUSIONS: Until researchers find a successful prevention or medical/surgical treatment for @entity3604 , health-care providers and society abandon these @entity1 to remain in a @entity158 and never ending story.

title: A @entity158 , never ending story: older @entity1 's experiences of living with an osteoporotic vertebral compression XXXX .

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture']


abstract: UNASSIGNED: @entity3814 ( @entity3814 ) cause @entity158 and decreased physical ability, with no known well-established treatment. The aim of this study was to illuminate the experience of living with a @entity3814 . The results show that fear and concerns are a major part of daily life. The @entity1 's initial contact with health-care providers should focus on making them feel acknowledged by offering @entity1 -centered and tailored support. INTRODUCTION: In the past decade, @entity3604 have become an increasingly common and costly public health problem worldwide. @entity3814 ( @entity3814 ) is the second most common @entity3604 , and @entity1 with @entity3814 describe an abrupt descent into disability, with a subsequent desire to regain independence in everyday life; however, little is known of their situation. The aim of this study was to illuminate the lived experience of @entity1 with an @entity3814 . METHODS: Ten @entity1 were interviewed during 2012-2013, starting with an open-ended question: could you tell me what it is like to live with a vertebral compression @entity174 ? The verbatim transcribed interviews were analyzed using a phenomenological hermeneutical approach. RESULTS: The narrative provided descriptions of living in turmoil and chaos, unable to find stability in their life with little improvement regarding @entity158 and physical function. Shifts from periods of @entity158 to periods of fear of @entity158 created a loss of confidence and an increased sense of confinement. The structural analysis revealed fear and concerns as the most prominent experience building on five themes: struggling to understand a deceiving body, @entity158 fueling fear, fearing a trajectory into isolation, concerns of dependency, and fearing an uncertain future. CONCLUSIONS: Until researchers find a successful prevention or medical/surgical treatment for @entity3604 , health-care providers and society abandon these @entity1 to remain in a @entity158 and never ending story.

title: A @entity158 , never ending story: older XXXX 's experiences of living with an osteoporotic vertebral compression @entity174 .

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND: @entity101 remains a major public health problem whose management is hampered by poor persistence with pharmacological therapy. The aim of this study was to evaluate the association between discontinuing @entity734 ( @entity734 ) and the risk of @entity65 in the elderly. METHODS: A population-based prospective cohort study of all of the >=  60-year-old residents in Bambu   city (Brazil) enrolled 1606 subjects (92.2%), of whom 1494 (93.0%) were included in this study. The use of @entity734 was ascertained annually in a real-clinical context, and time-varying @entity8404 exposure was categorised as non-use, current use or stopped. The predicted @entity65 rates were estimated using interval Poisson models for ungrouped @entity1 -time data, taking into account current levels of systolic blood pressure (BP). RESULTS: The overall adjusted @entity65 risk ratio of @entity8404 stoppers vs current users was 3.12 (95% CI: 2.35-4.15). There was a significant interaction with BP levels: the association between discontinuing @entity734 and the risk of @entity65 was stronger at higher systolic BP levels. The estimates of the risk of @entity65 over the follow-up period were similar in @entity8404 users and non-users, for whom @entity734 were never prescribed. CONCLUSION: Discontinuing @entity734 increases the risk of @entity65 in the elderly. Misconceptions about symptoms or drug-related adverse effects could underlie a subject's decision to discontinue @entity734 . Greater attention should be paid to the choice of @entity734 and informative action.

title: Discontinuation of anti- XXXX drugs increases 11-year @entity65 risk in community-dwelling elderly (the Bambu   Cohort Study of Ageing).

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['antihypertensive drugs', 'AHDs']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']