abstract: In a large multicentre sample of cognitively normal subjects, as a function of age, gender and @entity2204 genotype, we studied the frequency of abnormal cerebrospinal fluid levels of @entity195 biomarkers including: total tau, phosphorylated tau and amyloid-b1-42. Fifteen cohorts from 12 different centres with either enzyme-linked immunosorbent assays or Luminex   measurements were selected for this study. Each centre sent nine new cerebrospinal fluid aliquots that were used to measure total tau, phosphorylated tau and amyloid-b1-42 in the Gothenburg laboratory. Seven centres showed a high correlation with the new Gothenburg measurements; therefore, 10 cohorts from these centres are included in the analyses here (1233 healthy control subjects, 40-84 years old). Amyloid-b amyloid status (negative or positive) and @entity179 status (negative or positive) was established based on the pathological cerebrospinal fluid @entity195 cut-off values for cerebrospinal fluid amyloid-b1-42 and total tau, respectively. While gender did not affect these biomarker values, @entity2204 genotype modified the age-associated changes in cerebrospinal fluid biomarkers such that @entity2204 carriers showed stronger age-related changes in cerebrospinal fluid phosphorylated tau, total tau and amyloid-b1-42 values and @entity2204 carriers showed the opposite effect. At 40 years of age, 76% of the subjects were classified as amyloid negative, @entity179 negative and their frequency decreased to 32% at 85 years. The amyloid-positive @entity179 -negative group remained stable. The amyloid-negative @entity179 -positive group frequency increased slowly from 1% at 44 years to 16% at 85 years, but its frequency was not affected by @entity2204 genotype. The amyloid-positive @entity179 -positive frequency increased from 1% at 53 years to 28% at 85 years. Abnormally low cerebrospinal fluid amyloid-b1-42 levels were already frequent in midlife and @entity2204 genotype strongly affects the levels of cerebrospinal fluid amyloid-b1-42, phosphorylated tau and total tau across the lifespan without influencing the frequency of subjects with suspected non-amyloid pathology.

title: XXXX cerebrospinal fluid biomarker in cognitively normal subjects.

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"]

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegeneration']

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's disease']


abstract: BACKGROUND: The use of femoral @entity616 (FNB) combined with sciatic @entity616 (SNB) after total knee arthroplasty (TKA) has recently become controversial. @entity1337 ( @entity1337 ) has been reported to be effective for postoperative @entity158 control. We aimed to assess whether @entity1337 with continuous FNB is as effective as SNB combined with continuous FNB. METHODS: This was a prospective, randomized, single-center, observer-blinded, parallel group comparison trial of 34 American Society of Anesthesiologists (ASA) physical status 1-3 @entity1 who underwent TKA and fulfilled the inclusion and exclusion criteria. @entity1 were randomized into two groups: a periarticular @entity1337 and FNB group (group L, n   =   17), and an SNB and FNB group (group S, n   =   17). In both groups, @entity1 received FNB with 20  mL of 0.375  % @entity1342 , and 5  mL  h(-1) of 0.2  % @entity1342 after surgery. In group L, @entity1 received 100-ml injections of 0.2  % @entity1342 and 0.5  mg @entity1425 to the surgical region. In group S, @entity1 received SNB with 20  ml of 0.375  % @entity1342 . After TKA, Numeric Rating Scale (NRS) scores for the first 24  h post-operation were compared via repeated-measures analysis of variance (ANOVA) as the primary outcome. Other outcome measures included NRS score changes within groups, area under the curve for the NRS scores, total analgesic dose, change in knee flexion and extension, @entity158 control satisfaction, @entity390 and @entity391 , and hospital stay duration. RESULTS: NRS score changes were greater in group L than in group S (P   <   0.01, ANOVA) and greater in group L than in group S at three postoperative time points: 3  h (P   <   0.01), 6  h (P   <   0.01), and 12  h (P   =   0.013; Mann-Whitney U test). Changes in the mean NRS score were observed in each group (P   <   0.01, Friedman test). No significant differences were detected in the other outcome measures (Mann-Whitney U, Wilcoxon signed-rank, and chi-squared tests). CONCLUSIONS: Sciatic @entity616 with femoral @entity616 is superior to local anesthetic infiltration with femoral @entity616 for @entity282 control within 3-12  h of total knee arthroplasty. TRIAL REGISTRATION: UMIN-CTR ID: 000013364 R: 000015591.

title: Femoral nerve block-sciatic nerve block vs. femoral XXXX -local infiltration analgesia for total knee arthroplasty: a randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Patients', 'patients']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['epinephrine']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['Local infiltration analgesia', 'LIA']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['TKA pain', 'pain']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['nerve block']

answer: @entity616 :: (MESH:D006327,Disease) :: ['nerve block']


abstract: Aim. To study the efficacy and safety of subantimicrobial dose (SD) @entity3403 (50   mg/d) in @entity1 with active and moderate-to-severe @entity2743 ( @entity2743 ). Methods. Thirteen @entity1 with active and moderate-to-severe @entity2743 received once daily oral @entity3403 (50   mg/d) for 12   wk. Treatment response at 24   wk was used as the primary outcome, measured by a composite of improvement in @entity922 ( @entity922 ), @entity892 , motility, soft tissue swelling, @entity5768 , and eyelid aperture. Secondary outcome was the change of quality of life score (QoL, including visual functioning subscale and appearance subscale). Adverse events were also recorded. Results. Overall improvement was noted in eight out of 13 @entity1 (61.5%, 95% CI 31.6%-86.1%). Both @entity922 and soft tissue swelling significantly ameliorated in eight @entity1 at 24   wk. Five @entity1 (38.5%) had improvement in ocular motility of >= 8 degrees. Eyelid aperture (46.2%) also decreased remarkably. For QoL, a significant improvement in appearance subscale (P = 0.008) was noted during the study, whereas no difference was observed in visual functioning subscale (P = 0.21). Two @entity1 reported mild stomachache at 12   wk. Conclusions. SD @entity3403 appears to be effective and safe for the treatment of active and moderate-to-severe @entity2743 . It might serve as a new promising therapeutic strategy for @entity2743 . This trial is registered with NCT01727973.

title: Efficacy of Subantimicrobial Dose XXXX for Moderate-to-Severe and Active Graves' Orbitopathy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2743 :: ('MESH:D006111', 'Disease') :: ['GO', "Graves' orbitopathy"]

entities_list: @entity3403 :: ('MESH:D004318', 'Chemical') :: ['doxycycline']

entities_list: @entity5768 :: ('MESH:D005094', 'Disease') :: ['proptosis']

entities_list: @entity892 :: ('MESH:D004172', 'Disease') :: ['diplopia']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['Clinical Activity Score', 'CAS']

answer: @entity3403 :: (MESH:D004318,Chemical) :: ['Doxycycline']


abstract: Objective Approximately 5-10% of preschool age @entity1 are considered developmentally disabled. Brain Magnetic Resonance Imaging (MRI) plays a key role in the diagnostic evaluation in these @entity1 . Many congenital or acquired @entity75 are revealed with MRIs. Although the majority of these abnormalities are sporadic but @entity1 with @entity4289 or @entity4289 have sex-linked inheritance. We are going to present the first case in Iran from Ahvaz city, which was presented with @entity159 associated with @entity245 and finally diagnosed as @entity4289 , because @entity71489 cases especially for continuous or generalized form is rare. A 4.5-year-old developmentally delayed @entity1 was admitted for generalized tonic clonic @entity410 attack of 1 hr, upward gaze, @entity2133 , and @entity322 ( @entity159 ) in the @entity1 neurology ward. She had a history of recurrent @entity410 that @entity410 since she was 12 months of age and had frequent admissions for having recurrent @entity410 attacks. She was the only @entity1 of consanguineous parents with negative family history of any neurologic problems. She was a product of uneventful term pregnancy, vaginal delivery with a low Apgar score at birth who was admitted for six days in the neonatal ward for @entity2421 and @entity848 . At 4.5 years of age, she had HC: 45cm (<3%) Length: 102 cm (25-75%), and BW: 18kg (75%). She was able to sit, walk with support, speak a few words, and communicate with others. A physical exam was unremarkable. Lab data including CBC, blood biochemical, and urinalysis results were all within normal limits, but the electroencephalography (EEG) revealed generalized poly spike-wave discharges. A brain MRI showed @entity15261 , generalized @entity71489 , and @entity8568 . She was discharged home with oral @entity1092 and regular outpatient follow-ups. In the diagnostic evaluation of developmentally delayed and @entity302 @entity1 , a brain MRI is strongly recommended for accurate diagnosis of anomalies such as @entity12198 ( @entity71489 ) and others, because appropriate therapeutic management, prognosis, prevention, and genetic counseling for prenatal diagnosis are dependent on definite diagnosis of the proband case.

title: Double Cortex Syndrome ( XXXX ): A Case Report.

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'children', 'girl', 'patients']

entities_list: @entity4289 :: ('MESH:D054221', 'Disease') :: ['double cortex syndrome', 'subcortical band heterotopia']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures', 'started as febrile seizures']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['urinary incontinence']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain anomalies']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['locked mouth']

entities_list: @entity8568 :: ('MESH:D065706', 'Disease') :: ['polymicrogyria']

entities_list: @entity1092 :: ('MESH:D014635', 'Chemical') :: ['valproate']

entities_list: @entity245 :: ('MESH:D002658', 'Disease') :: ['developmental delay']

entities_list: @entity12198 :: ('MESH:D054081', 'Disease') :: ['neuronal migration disorders']

entities_list: @entity71489 :: ('MESH:C563950', 'Disease') :: ['band heterotopia']

entities_list: @entity2421 :: ('MESH:D009123', 'Disease') :: ['hypotonia']

entities_list: @entity15261 :: ('MESH:D002145', 'Disease') :: ['corpus callosal dysplasia']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic']

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['status epilepticus']

entities_list: @entity848 :: ('MESH:D003490', 'Disease') :: ['cyanosis']

answer: @entity4289 :: (MESH:D054221,Disease) :: ['Subcortical Band Heterotopia']


abstract: AIM: To update our experiences with minimally invasive McKeown esophagectomy for @entity418 . METHODS: We retrospectively reviewed the medical records of 445 consecutive @entity1 who underwent minimally invasive McKeown esophagectomy between January 2009 and July 2015 at the @entity5 Hospital of Chinese Academy of Medical Sciences and used 103 @entity1 who underwent open McKeown esophagectomy in the same period as controls. Among 375 @entity1 who underwent total minimally invasive McKeown esophagectomy, 180 in the early period were chosen for the study of learning curve of total minimally invasive McKeown esophagectomy. These 180 minimally invasive McKeown esophagectomies performed by five surgeons were divided into three groups according to time sequence as group 1 (n = 60), group 2 (n = 60) and group 3 (n = 60). RESULTS: @entity1 who underwent total minimally invasive McKeown esophagectomy had significantly less intraoperative @entity190 than @entity1 who underwent hybrid minimally invasive McKeown esophagectomy or open McKeown esophagectomy (100 mL vs 300 mL vs 200 mL, P = 0.001). However, there were no significant differences in operation time, number of harvested lymph nodes, or postoperative morbidity including incidence of @entity358 and @entity834 between total minimally invasive McKeown esophagectomy, hybrid minimally invasive McKeown esophagectomy and open McKeown esophagectomy groups. There were no significant differences in 5-year survival between these three groups (60.5% vs 47.9% vs 35.6%, P = 0.735). @entity1 in group 1 had significantly longer duration of operation than those in groups 2 and 3. There were no significant differences in intraoperative @entity190 , number of harvested lymph nodes, or postoperative morbidity including incidence of @entity358 and @entity834 between groups 1, 2 and 3. CONCLUSION: Total minimally invasive McKeown esophagectomy was associated with @entity190 and comparable short term and long term survival compared with hybrid minimally invasive McKeown esophagectomy or open Mckeown esophagectomy. At least 12 cases are needed to master total minimally invasive McKeown esophagectomy in a high volume center.

title: Updated experiences with minimally invasive McKeown esophagectomy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity834 :: ('MESH:D057868', 'Disease') :: ['anastomotic leak']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss', 'reduced intraoperative blood loss']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complication']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

answer: @entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']


abstract: AIM: To compare the outcomes between the Stretta procedure and laparoscopic toupet fundoplication (LTF) in @entity1 with @entity354 ( @entity354 )-related extra-esophageal symptoms. METHODS: From January 2011 to February 2012, a total of 98 @entity1 diagnosed with @entity354 -related extra-esophageal symptoms who met the inclusion criteria were enrolled in this study. All @entity1 who either underwent the Stretta procedure or LTF treatment have now completed the 3-year follow-up. Primary outcome measures, including frequency and severity of extra-esophageal symptoms, proton pump inhibitor (PPI) use, satisfaction, and @entity260 , were assessed. The results of the Stretta procedure and LTF therapy were analyzed and compared. RESULTS: There were 47 @entity1 in the Stretta group and 51 @entity1 in the LTF group. Ninety @entity1 were available at the 3-year follow-up. The total of the frequency and severity scores for every symptom improved in both groups (P < 0.05). Improvement in symptom scores of cough, sputum, and wheezing did not achieve statistical significance between the two groups (P > 0.05). However, the score for globus hysterics was different between the Stretta group and the LTF group (4.9    2.24 vs 3.2    2.63, P < 0.05). After the Stretta procedure and LTF treatment, 29 and 33 @entity1 in each group achieved PPI therapy independence (61.7% vs 64.7%, P = 0.835). The @entity1 in the LTF group were more satisfied with their quality of life than those in the Stretta procedure group (P < 0.05). Most complications resolved without intervention within two weeks; however, two @entity1 in the LTF group still suffered from severe @entity1282 2 wk after the operation, and it improved after bougie dilation treatment in both @entity1 . CONCLUSION: The Stretta procedure and LTF were both safe and effective for the control of @entity354 -related extra-esophageal symptoms and the reduction of PPI use.

title: Comparison of Stretta procedure and toupet fundoplication for XXXX -related extra-esophageal symptoms.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease', 'GERD']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

answer: @entity354 :: (MESH:D005764,Disease) :: ['gastroesophageal reflux disease']


abstract: BACKGROUND: The prognostic role of swallowing-related, pretreatment subjective and objective findings has not been investigated in detail. The authors evaluated the association between pretreatment MD Anderson @entity1282 Inventory (MDADI) or videofluorographic swallowing study (VFSS) results and standard outcomes, including early recurrence and survival, in @entity1 with treatment-na  ve @entity213 ( @entity213 ). METHODS: @entity1 with @entity213 (n   =   191) who received treatment at the authors' institution and were examined by self-administered MDADI questionnaires and VFSS were prospectively enrolled. MDADI and VFSS findings were analyzed in correlation with clinicopathologic variables, and factors that predicted 2-year disease-free survival (DFS) and overall survival (OS) were identified using a Cox proportional-hazards regression model. RESULTS: The 2-year OS and DFS rates were 80.1% and 77.5%, respectively. @entity5 ( @entity5 ) and lymph node (N) classifications, overall TNM stage, sex, @entity5 site, and educational level were significantly associated with specific MDADI subdomains, whereas Karnofsky performance score was significantly associated with all MDADI subdomains. After controlling for clinical factors, total scores, global assessment scores, and emotional and physical MDADI subscores were significantly predictive of 2-year OS and DFS (P   <   .05 for each). VFSS findings were not significantly associated with survival (P   >   .05). CONCLUSIONS: The current results provide evidence of the prognostic role of the MDADI in predicting early survival outcomes in @entity1 with @entity213 . The MDADI may be a practical and noninvasive method for the identification of @entity1 at risk who would benefit from close follow-up.

title: Pretreatment XXXX Inventory and videofluorographic swallowing study as prognostic indicators of early survival outcomes in head and neck cancer.

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Clinical tumor', 'T']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['Dysphagia']

answer: @entity1282 :: (MESH:D003680,Disease) :: ['Dysphagia']


abstract: UNASSIGNED: The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin I-converting enzyme gene ( @entity1289 ) has been extensively studied as a predisposing factor for idiopathic recurrent @entity2208 (IRSA). A case-control study including 149 @entity1 with >= 3 spontaneous @entity5852 and 149 controls was performed to test the association of @entity1289 I/D polymorphism with IRSA. A systematic review was conducted of previous case-control studies, with strict selection criteria for meta-analyses. We also aimed to evaluate the potential differences in summary estimates between studies defining IRSA as >= 2 and >= 3 spontaneous @entity5852 . Genotyping was performed by PCR, and systematic review conducted using PubMed and Scopus. There was no association of the polymorphism with IRSA in Slovenian @entity1 . Sixteen case-control studies, showing substantial differences regarding IRSA definition and selection criteria for @entity1 were identified. Meta-analysis was performed and included four studies defining IRSA as >= 2 spontaneous @entity5852 and the current study, which defined IRSA as >= 3 spontaneous @entity5852 . Based on random effects model, meta-analysis conducted on 1192 @entity1 and 736 controls showed no association with IRSA under dominant(DD+IDvsII) and recessive(DDvsID+II) genetic models. Well-designed studies are needed to evaluate the role of @entity1289 I/D polymorphism in IRSA defined as >= 3 spontaneous @entity5852 .

title: Insertion/deletion polymorphism in intron 16 of XXXX gene in idiopathic recurrent @entity2208 : case-control study, systematic review and meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity2208 :: ('MESH:D000022', 'Disease') :: ['spontaneous abortion']

entities_list: @entity5852 :: ('MESH:D000031', 'Disease') :: ['abortions']

answer: @entity1289 :: (1636,Gene) :: ['ACE']


abstract: UNASSIGNED: The insertion/deletion (I/D) polymorphism in intron 16 of the angiotensin I-converting enzyme gene ( @entity1289 ) has been extensively studied as a predisposing factor for idiopathic recurrent @entity2208 (IRSA). A case-control study including 149 @entity1 with >= 3 spontaneous @entity5852 and 149 controls was performed to test the association of @entity1289 I/D polymorphism with IRSA. A systematic review was conducted of previous case-control studies, with strict selection criteria for meta-analyses. We also aimed to evaluate the potential differences in summary estimates between studies defining IRSA as >= 2 and >= 3 spontaneous @entity5852 . Genotyping was performed by PCR, and systematic review conducted using PubMed and Scopus. There was no association of the polymorphism with IRSA in Slovenian @entity1 . Sixteen case-control studies, showing substantial differences regarding IRSA definition and selection criteria for @entity1 were identified. Meta-analysis was performed and included four studies defining IRSA as >= 2 spontaneous @entity5852 and the current study, which defined IRSA as >= 3 spontaneous @entity5852 . Based on random effects model, meta-analysis conducted on 1192 @entity1 and 736 controls showed no association with IRSA under dominant(DD+IDvsII) and recessive(DDvsID+II) genetic models. Well-designed studies are needed to evaluate the role of @entity1289 I/D polymorphism in IRSA defined as >= 3 spontaneous @entity5852 .

title: Insertion/deletion polymorphism in intron 16 of @entity1289 gene in idiopathic recurrent XXXX : case-control study, systematic review and meta-analysis.

answer: @entity2208 :: (MESH:D000022,Disease) :: ['spontaneous abortion']


abstract: OBJECTIVE: It has been shown that Mesenchymal stem cells (MSCs) could prevent or alleviate @entity647 ( @entity647 ) when transplanted into lung; however, the mechanisms involved remains elusive. The study aimed to investigate the effect of MSCs in repairing alveolar fluid clearance (AFC) of @entity133 ( @entity133 ) cells through paracrine factors. MATERIALS AND METHODS: @entity11943 ( @entity11943 ) concentration in the supernatant of MSC culture medium was measured, and MSCs in lung after intravenous administration was traced. Next, MSCs transfected with or without @entity11943 SiRNA were injected intravenously into LPS-induced @entity647 @entity35 . Histological change and wet/dry ratio were determined. @entity133 cells were co-cultured with MSCs under different experimental situations to analyze the variation of @entity48414 subunits of @entity4024 - @entity3529 -ATPase in @entity133 cells. RESULTS: LPS-induced @entity647 was characterized by the typical inflammatory infiltrates, interalveolar septal thickening and increased wet/dry ratio. MSC administration significantly reduced the injury, while MSCs with @entity11943 knockdown did no show the same effect. In vitro study also confirmed that expressions of @entity48414 subunit were up-regulated as impaired @entity133 cells co-cultured with MSCs. Furthermore, expression of a1 subunit was down-regulated, while b1 subunit showed no apparent change as @entity133 cells were co-cultured with MSCs that were transfected with @entity11943 siRNA. CONCLUSIONS: AFC was @entity32 insult. MSCs-derived @entity11943 reduced the impaired AFC through up-regulated a1 subunit but not b1 subunit, which might provide a novel therapeutic strategy for @entity647 .

title: Mesenchymal stem cells ameliorate LPS-induced XXXX through @entity11943 promoting alveolar fluid clearance of alveolar type II cells.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['impaired by inflammation']

entities_list: @entity11943 :: ('29348(Tax:10116)', 'Gene') :: ['Keratinocyte growth factor', 'KGF']

entities_list: @entity133 :: ('MESH:D002282', 'Disease') :: ['AT-II', 'alveolar type-II']

entities_list: @entity647 :: ('MESH:D055371', 'Disease') :: ['acute lung injury', 'ALI']

answer: @entity647 :: (MESH:D055371,Disease) :: ['acute lung injury']


abstract: OBJECTIVE: It has been shown that Mesenchymal stem cells (MSCs) could prevent or alleviate @entity647 ( @entity647 ) when transplanted into lung; however, the mechanisms involved remains elusive. The study aimed to investigate the effect of MSCs in repairing alveolar fluid clearance (AFC) of @entity133 ( @entity133 ) cells through paracrine factors. MATERIALS AND METHODS: @entity11943 ( @entity11943 ) concentration in the supernatant of MSC culture medium was measured, and MSCs in lung after intravenous administration was traced. Next, MSCs transfected with or without @entity11943 SiRNA were injected intravenously into LPS-induced @entity647 @entity35 . Histological change and wet/dry ratio were determined. @entity133 cells were co-cultured with MSCs under different experimental situations to analyze the variation of @entity48414 subunits of @entity4024 - @entity3529 -ATPase in @entity133 cells. RESULTS: LPS-induced @entity647 was characterized by the typical inflammatory infiltrates, interalveolar septal thickening and increased wet/dry ratio. MSC administration significantly reduced the injury, while MSCs with @entity11943 knockdown did no show the same effect. In vitro study also confirmed that expressions of @entity48414 subunit were up-regulated as impaired @entity133 cells co-cultured with MSCs. Furthermore, expression of a1 subunit was down-regulated, while b1 subunit showed no apparent change as @entity133 cells were co-cultured with MSCs that were transfected with @entity11943 siRNA. CONCLUSIONS: AFC was @entity32 insult. MSCs-derived @entity11943 reduced the impaired AFC through up-regulated a1 subunit but not b1 subunit, which might provide a novel therapeutic strategy for @entity647 .

title: Mesenchymal stem cells ameliorate LPS-induced @entity647 through XXXX promoting alveolar fluid clearance of alveolar type II cells.

answer: @entity11943 :: (29348(Tax:10116),Gene) :: ['KGF']


abstract: OBJECTIVE: General anesthesia in @entity28 @entity1 is both challenging and demanding. With the rates of @entity28 in the general population increasing, more @entity1 undergo bariatric surgery. The aim of this study was to compare the performance, effectiveness and recovery from anesthesia of @entity2614 and @entity1875 in combination with @entity1937 , with and without bispectral index (BIS) monitoring in super @entity28 @entity1 undergoing bariatric surgery. @entity1 AND METHODS: In this prospective, double-blind, randomized, controlled study a total of 100 super @entity28 @entity1 (body mass index, BMI > 50 kg/m2) undergoing bariatric surgery were randomly allocated in four groups: a @entity2614 group (n = 25), a @entity2614 with BIS monitoring group (n = 25), a @entity1875 group (n=25) and a @entity1875 with BIS monitoring group (n=25). Hemodynamic parameters, depth of anesthesia, recovery from anesthesia and @entity282 were recorded. RESULTS: The mean age of @entity1 was 37.7    9.2 years and the median BMI was 57.86    9.33. There were no statistically significant differences between the four groups with respect to @entity1 characteristics, comorbidities and duration of surgery. The intraoperatively mean arterial pressure was significantly higher in both @entity1875 groups. No significant difference was observed between the four groups in respect to heart rate changes during anesthesia. Although the time to eye-opening and extubation was significantly shorter in both @entity1875 groups, recovery from anesthesia, assessed with the Aldrete, Chung and White recovery scores, was significantly faster in @entity2614 groups. No significant difference was observed in @entity282 between the four groups. CONCLUSIONS: Although both @entity1875 and @entity2614 provide adequate general anesthesia, @entity2614 may be preferable in super @entity28 @entity1 because of superior hemodynamic stability and faster recovery from anesthesia.

title: Anesthesia management for the super @entity28 : is XXXX superior to @entity1875 as a sole anesthetic agent? A double-blind randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity1875 :: ('MESH:D015742', 'Chemical') :: ['propofol']

entities_list: @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity1937 :: ('MESH:C071741', 'Chemical') :: ['remifentanil']

answer: @entity2614 :: (MESH:C009250,Chemical) :: ['sevoflurane']


abstract: OBJECTIVE: General anesthesia in @entity28 @entity1 is both challenging and demanding. With the rates of @entity28 in the general population increasing, more @entity1 undergo bariatric surgery. The aim of this study was to compare the performance, effectiveness and recovery from anesthesia of @entity2614 and @entity1875 in combination with @entity1937 , with and without bispectral index (BIS) monitoring in super @entity28 @entity1 undergoing bariatric surgery. @entity1 AND METHODS: In this prospective, double-blind, randomized, controlled study a total of 100 super @entity28 @entity1 (body mass index, BMI > 50 kg/m2) undergoing bariatric surgery were randomly allocated in four groups: a @entity2614 group (n = 25), a @entity2614 with BIS monitoring group (n = 25), a @entity1875 group (n=25) and a @entity1875 with BIS monitoring group (n=25). Hemodynamic parameters, depth of anesthesia, recovery from anesthesia and @entity282 were recorded. RESULTS: The mean age of @entity1 was 37.7    9.2 years and the median BMI was 57.86    9.33. There were no statistically significant differences between the four groups with respect to @entity1 characteristics, comorbidities and duration of surgery. The intraoperatively mean arterial pressure was significantly higher in both @entity1875 groups. No significant difference was observed between the four groups in respect to heart rate changes during anesthesia. Although the time to eye-opening and extubation was significantly shorter in both @entity1875 groups, recovery from anesthesia, assessed with the Aldrete, Chung and White recovery scores, was significantly faster in @entity2614 groups. No significant difference was observed in @entity282 between the four groups. CONCLUSIONS: Although both @entity1875 and @entity2614 provide adequate general anesthesia, @entity2614 may be preferable in super @entity28 @entity1 because of superior hemodynamic stability and faster recovery from anesthesia.

title: Anesthesia management for the super XXXX : is @entity2614 superior to @entity1875 as a sole anesthetic agent? A double-blind randomized controlled trial.

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: OBJECTIVE: General anesthesia in @entity28 @entity1 is both challenging and demanding. With the rates of @entity28 in the general population increasing, more @entity1 undergo bariatric surgery. The aim of this study was to compare the performance, effectiveness and recovery from anesthesia of @entity2614 and @entity1875 in combination with @entity1937 , with and without bispectral index (BIS) monitoring in super @entity28 @entity1 undergoing bariatric surgery. @entity1 AND METHODS: In this prospective, double-blind, randomized, controlled study a total of 100 super @entity28 @entity1 (body mass index, BMI > 50 kg/m2) undergoing bariatric surgery were randomly allocated in four groups: a @entity2614 group (n = 25), a @entity2614 with BIS monitoring group (n = 25), a @entity1875 group (n=25) and a @entity1875 with BIS monitoring group (n=25). Hemodynamic parameters, depth of anesthesia, recovery from anesthesia and @entity282 were recorded. RESULTS: The mean age of @entity1 was 37.7    9.2 years and the median BMI was 57.86    9.33. There were no statistically significant differences between the four groups with respect to @entity1 characteristics, comorbidities and duration of surgery. The intraoperatively mean arterial pressure was significantly higher in both @entity1875 groups. No significant difference was observed between the four groups in respect to heart rate changes during anesthesia. Although the time to eye-opening and extubation was significantly shorter in both @entity1875 groups, recovery from anesthesia, assessed with the Aldrete, Chung and White recovery scores, was significantly faster in @entity2614 groups. No significant difference was observed in @entity282 between the four groups. CONCLUSIONS: Although both @entity1875 and @entity2614 provide adequate general anesthesia, @entity2614 may be preferable in super @entity28 @entity1 because of superior hemodynamic stability and faster recovery from anesthesia.

title: Anesthesia management for the super @entity28 : is @entity2614 superior to XXXX as a sole anesthetic agent? A double-blind randomized controlled trial.

answer: @entity1875 :: (MESH:D015742,Chemical) :: ['propofol']


abstract: OBJECTIVES: The incidence of @entity1489 , @entity320 in particular, is increasing rapidly. Consequently, specific recommendations for sun-protection measures now exist. This survey set out to assess the compliance of the general population with these guidelines. METHODS: The French nationwide observational survey, EDIFICE @entity320 , was conducted (28 September to 20 October 2011) through phone interviews of a representative sample of 1502 subjects aged >=   18  years, using the quota method. Sun-protection was defined as frequent or systematic use of clothes or sunscreen. The group of individuals who declared exposure to the sun (N  =  1172) was subdivided: risk-takers (N  =  442), and those who used sun protection (N  =  730). RESULTS: Risk-takers were significantly more often male (62% vs. 44%, P  <  0.01), had a lower level of education (40% vs. 26%, P  <  0.01), lower incomes (2587 @entity7634 vs. 2948 @entity7634 /month) and were more often smokers (42% vs. 31%, P  <  0.01). In contrast, age, marital status and use of sunbeds were not significantly different between the two groups. Interestingly, risk-takers had less risk factors for @entity320 . However, they were less well-informed about high-risk exposure and optimal use of sunscreen. Sun-protection measures for their @entity1 were less stringent than those of the group who used sun protection: systematic/frequent use of sunglasses (42% vs. 59%, P  <  0.01), systematic use of sunscreen (77% vs. 86%, P  <  0.01), and frequent renewal (69% vs. 82%, P  <  0.01), high sun protection factors (SPF) (46% vs. 56%, P  <  0.01), use of clothing (84% vs. 92%, P  <  0.01) and hats (88% vs. 94%, P  <  0.01). CONCLUSIONS: Risk-takers are characterized by a lesser understanding of sun-protection measures and behaviours. Their @entity1 benefit less from protective measures than those of @entity1 who use sun protection themselves. Improved understanding may well improve behaviours; one can therefore legitimately predict a considerable impact on parents' attitude to their own protection and that of their @entity1 .

title: XXXX risk-takers: fathers and sons.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'people']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['skin cancers']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma', 'Melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['Melanoma']


abstract: UNASSIGNED: There are differences in reporting @entity548 complications after transcatheter aortic valve implantation (TAVI), which is a consequence of the lack of consensus for their definition. Furthermore, the amount of data on the impact of peri-procedural @entity548 on the mid-term prognosis is still limited. The aim of this study was to investigate the incidence, predictors, and impact of life-threatening and major bleedings as defined by the Valve Academic Research Consortium 2 (VARC-2) in @entity1 after TAVI over the mid-term prognosis.Consecutive @entity1 who underwent TAVI from March 2010 to December 2013 were included. All data were classified according to the VARC-2 criteria. We assessed the incidence and the predictors of @entity548 ( @entity548 ), defined as life-threatening/disabling (LT/D) or major @entity548 , and analyzed their impact on 30-day and 1-year clinical outcome.A total of 129 @entity1 were included (79.1    8.3 years; mean EuroSCORE = 17.8    12.7). The @entity548 occurred in 25 @entity1 (19.4%), of which 9 (7.0%) had LT/D and 16 (12.4%) had major @entity548 . @entity10747 ( @entity10747 ) access (OR 4.38, 95% CI 2.13-14.29, P = 0.01) and @entity6 (OR 2.93, 95% CI 1.08-7.93, P = 0.03) were identified as independent predictors of @entity548 . @entity1 with @entity548 had higher 30-day mortality (20.0% versus 4.0% P = 0.02) and 1-year mortality (40.0% versus 11.1%, P < 0.002). @entity548 independently predicted 1-year, all-cause mortality (HR 5.88, 95% CI 1.7319,94, P = 0.005). @entity548 are frequent after TAVI and are associated with decreased short and mid-term survival. @entity6 and @entity10747 access are independent risk factors for @entity548 .

title: Incidence, Predictors and Impact of Severe Periprocedural Bleeding According to VARC-2 Criteria on 1-Year Clinical Outcomes in XXXX After Transcatheter.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity10747 :: ('MESH:D012183', 'Disease') :: ['TS', 'Trans-subclavian']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['SBE', 'bleeding', 'serious bleeding events']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: The objective of this study was to investigate the relationship between @entity3 -associated in @entity694 and @entity1 clinical characteristics. We also examined the role of @entity3 -associated in @entity694 in the proliferation and apoptosis in @entity2347 . MATERIAL AND METHODS: @entity3 -associated in @entity694 expression was analysed in 65 @entity982 -embedded tissue specimens of salivary @entity2347 and 25 adjacent non-cancerous tissues by immunohistochemistry (IHC). We used RNA interference technology to silence @entity3 -associated in @entity694 expression in ACCM cells. Cell Counting Kit-8 tests, transwell experiments and flow cytometry were used to test the proliferation, @entity900 resistance, migration, invasion and apoptosis of ACCM cells. RESULTS: @entity3 -associated in @entity694 nuclear and cytoplasmic expression in salivary @entity2347 tissue was higher than in the adjacent normal salivary tissue. The expression level was closely associated with @entity5 histological grading, perineural invasion and surrounding @entity5 invasion. The downregulation of @entity3 -associated in @entity694 expression inhibited proliferation and induced apoptosis in ACCM cells. The knock-down of @entity3 -associated in @entity694 expression had no effect on migration, invasion and chemoresistance. CONCLUSIONS: @entity3 -associated in @entity694 may have an important role in @entity5 development in @entity2347 . @entity3 -associated in @entity694 is a potential biomarker for @entity2347 .

title: The expression of MACC1 and its role in the proliferation and apoptosis of salivary XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumour']

entities_list: @entity2347 :: ('MESH:D003528', 'Disease') :: ['adenoid cystic carcinoma']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis', 'Metastasis']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer-1']

answer: @entity2347 :: (MESH:D003528,Disease) :: ['adenoid cystic carcinoma']


abstract: UNASSIGNED: Recent advances in neuroradiological techniques have increasingly improved the diagnosis rate for @entity439 , particularly with the widespread use of three-dimensional cerebral angiography. However, the treatment of @entity439 remains a considerable challenge for neurosurgeons. Endovascular coiling has emerged as a potential treatment option for @entity438 . The aim of the present study was to evaluate the safety and efficacy of Solitaire AB stent-assisted coiling embolization for the treatment of ruptured very small @entity438 . This retrospective study included nine consecutive @entity1 with ruptured very small @entity438 ( <=3 mm) that underwent Solitaire AB stent-assisted coiling embolization. The @entity439 were located in the ophthalmic branch of the internal carotid artery (n=2), the posterior communicating branch of the internal carotid artery (n=4), the top of the basilar artery (n=1) and the middle cerebral artery (n=2). Solitaire AB stents were successfully implanted in all nine @entity1 . Of the nice individuals, six @entity1 exhibited complete occlusion at Raymond grade I and three @entity1 exhibited occlusion at Raymond grade II. No @entity1756 was observed during the surgery. During the follow-up period of 8-13 months, no @entity932 occurred. A total of seven @entity1 underwent follow-up digital subtraction angiography at 5-10 months post-intervention. No recurrence of the @entity439 and no @entity850 or occlusion of the parent arteries was observed. Therefore, Solitaire AB stent-assisted coil embolization was demonstrated to be a safe and effective treatment for ruptured very small @entity438 . The long-term efficacy of this technique may be improved by increasing the packing density around the aneurysmal neck and improving the hemodynamics.

title: Solitaire AB stent-assisted coiling embolization for the treatment of ruptured very small XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['intracranial hemorrhage']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'very small aneurysms']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['aneurysm rupture']

answer: @entity438 :: (MESH:D002532,Disease) :: ['intracranial aneurysms']


abstract: Many deaths of wild birds that have drunk water contaminated with hepatotoxic @entity12219 -producing cyanobacteria have been reported. A mass @entity204 of egrets and herons with @entity63486 were found at the agricultural reservoir occurring cyanobacterial waterblooms. This study aimed to verify a hypothesis that the egrets and herons which died in the reservoir drink @entity12219 -producing cyanobacteria and @entity12219 involves in the cause of @entity204 as well as the symptoms of @entity63486 . The cyanobacterial community in gastric contents of egrets and herons that died from @entity63486 was assessed using cyanobacterial 16S rRNA-based terminal-restriction fragment length polymorphism (T-RFLP) profiling and a cyanobacterial 16S rRNA-based clone library analysis. In addition, PCR amplification of the mcyB-C region and the mcyG gene, involved in @entity12219 biosynthesis, was examined. The cyanobacterial community in the gastric contents of two birds showed a simplistic composition. A comparison of cyanobacterial T-RFLP profiling and cloned sequences suggested that the genus Microcystis predominated in both samples of egrets died. Although we confirmed that two egrets which died in the reservoir have taken in cyanobacterial waterblooms containing the genus Microcystis, no mcy gene was detected in both samples according to the mcy gene-based PCR analysis. This study is the first to show the profiling and traceability of a cyanobacterial community in the gastric contents of wild birds by molecular analysis. Additionally, we consider causing symptoms of @entity63486 in the dead egrets.

title: Molecular Analysis of the Cyanobacterial Community in Gastric Contents of Egrets with Symptoms of XXXX .

entities_list: @entity12219 :: ('MESH:C078588', 'Chemical') :: ['microcystin']

answer: @entity63486 :: (MESH:D013231,Disease) :: ['Steatitis']


abstract: BACKGROUND AND OBJECTIVES: Many surface proteins are implicated in nasopharyngeal colonization and pathogenesis of @entity328 . Some of these factors are candidate antigens for protein based vaccines. New vaccine designs focus on the surface proteins (e. g., pspA and pspC) and also cytolysin, and pneumolysin. In this study, 3 key virulence genes, lytA, pspC, and rrgA, which encoded surface proteins, were detected among @entity2260 isolates. MATERIALS AND METHODS: A total of 260 nasopharyngeal swabs were collected from healthy @entity1 under 6 years old attending day care centers in Mashhad, Iran. Isolates of @entity2260 were confirmed by optochin susceptibility and colony appearance and also by PCR for cpsA gene. The presence of lytA, pspC, and rrgA genes were also detected by PCR. RESULTS: A total of 59 isolates were confirmed as @entity2260 . Among these isolates, 50 (84.74%), 19 (32.20%), and 2 (3.38%) were positive for lytA, rrgA, and pspC genes respectively. The presence of these genes among @entity2260 isolates were as follows: 1) rrgA, lytA, pspC (1 isolate), 2) rrgA, lytA(17isolates), 3) pspC (2 isolate), 4) lytA (50 isolates). CONCLUSION: cpsA gene was specific for detection of @entity2260 isolates which were colonized in nasopharynx. The lytA gene was the most frequent gene among the @entity2260 isolates, and combination of rrgA, lytA was the most observed pattern. Thus, it is important for future monitoring of vaccine formulation in our country.

title: Detection of lytA, pspC, and rrgA genes in XXXX isolated from healthy @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity2260 :: ('2104', 'Species') :: ['S. pneumoniae', 'S.pneumoniae']

entities_list: @entity328 :: ('1313', 'Species') :: ['Streptococcus pneumoniae']

answer: @entity328 :: (1313,Species) :: ['Streptococcus pneumoniae']


abstract: BACKGROUND AND OBJECTIVES: Many surface proteins are implicated in nasopharyngeal colonization and pathogenesis of @entity328 . Some of these factors are candidate antigens for protein based vaccines. New vaccine designs focus on the surface proteins (e. g., pspA and pspC) and also cytolysin, and pneumolysin. In this study, 3 key virulence genes, lytA, pspC, and rrgA, which encoded surface proteins, were detected among @entity2260 isolates. MATERIALS AND METHODS: A total of 260 nasopharyngeal swabs were collected from healthy @entity1 under 6 years old attending day care centers in Mashhad, Iran. Isolates of @entity2260 were confirmed by optochin susceptibility and colony appearance and also by PCR for cpsA gene. The presence of lytA, pspC, and rrgA genes were also detected by PCR. RESULTS: A total of 59 isolates were confirmed as @entity2260 . Among these isolates, 50 (84.74%), 19 (32.20%), and 2 (3.38%) were positive for lytA, rrgA, and pspC genes respectively. The presence of these genes among @entity2260 isolates were as follows: 1) rrgA, lytA, pspC (1 isolate), 2) rrgA, lytA(17isolates), 3) pspC (2 isolate), 4) lytA (50 isolates). CONCLUSION: cpsA gene was specific for detection of @entity2260 isolates which were colonized in nasopharynx. The lytA gene was the most frequent gene among the @entity2260 isolates, and combination of rrgA, lytA was the most observed pattern. Thus, it is important for future monitoring of vaccine formulation in our country.

title: Detection of lytA, pspC, and rrgA genes in @entity328 isolated from healthy XXXX .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: Early coronary angiography and computed tomography are recommended in survivors of out-of-hospital @entity1167 (OHCA). However, both techniques require iodinated contrast agent although the effects on incident @entity810 are unknown. The aim of this study was to explore the incidence of @entity810 ( @entity810 ) and need for renal replacement therapy (RRT) in @entity1 after nontraumatic OHCA with special regard to the administration of contrast agent during the early in-hospital diagnostic workup. MATERIALS AND METHODS: Data from all survivors of OHCA admitted to our hospital between 1  January  2008 and 30  June  2015 were retrospectively collected. Incidence of @entity810 and RRT between the contrast and no contrast groups were compared. RESULTS: Of 280  OHCA survivors, 133 (47.5   %) received contrast agent (227.0        136.5  ml). Within 72  h after hospital admission, 47 of 129 survivors (36.4   %) developed @entity810 of any stage, but @entity810 was more common in @entity1 without early contrast administration than in @entity1 with early contrast administration (54.5 vs. 28.2   %; p   =   0.011). @entity1 who survived until hospital discharge had higher serum @entity1011 levels at admission than at hospital discharge (1.17        0.37 vs. 0.92        0.35; p   <   0.001). CONCLUSION: @entity810 is common in survivors of OHCA, and RRT following OHCA is needed more frequently than in other @entity299 . Despite elevated serum @entity1011 levels at admission, we could not show an association between early contrast administration in survivors of OHCA and @entity810 incidence.

title: [Acute kidney injury and renal replacement therapy in victims from out-of-hospital XXXX with administration of contrast agent].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute kidney injuries', 'AKI', 'acute kidney injury']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac disease']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

answer: @entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']


abstract: UNASSIGNED: Our objective was to evaluate the safety and clinical efficacy of autologous M2 macrophage transplantation in non-acute @entity64 @entity1 . We also evaluated whether the intrathecal administration of macrophages influences the production of cytokines by peripheral blood cells, and whether the levels of cytokines correlate with @entity64 severity and responsiveness to celltherapy. For this, thirteen @entity1 (12 males and one female with median 63 years) diagnosed with @entity63 (n=10) or @entity548 (n=3) @entity64 have been subjected to cell transplantation therapy (study group). On average 21.9 x 10(6) of autologous M2 macrophages were injected via intrathecal introduction. Thirteen matched case-control @entity64 @entity1 who did not receive cell therapy formed the control group. We did not observe any serious adverse events, i.e. intrahospital mortality, neurological worsening and @entity410 , related to the cell injection. One @entity1 in the study group and two @entity1 in the control group died during the 6-mo follow-up period due to the recurrent @entity64 . In the study group the NIHSS score decreased from 11 to 6 (p=0.007) in 6 mo after the therapy, whereas the @entity1 in the control group showed a less pronounced neurological improvement (the NIHSS score decreased from 11 to 8; p=0.07). The obvious positive response (the improvement of the NIHSS score >= 3) in the study group was observed in 75% versus 18% in the control group (pFET=0.03). M2-cell introduction did not significantly affect the production of various cytokines. Nevertheless, pretreated levels of @entity687 , @entity688 and @entity3646 correlated with @entity64 severity. Moreover, responder @entity1 were differed from non-responders by lower spontaneous production of @entity688 , @entity540 , PDGF, @entity7 and higher stimulation indexes of @entity1356 , @entity310 , @entity379 and @entity650 . These findings suggest that the intrathecal administration of autologous M2 cells in @entity64 @entity1 is safe and leads to a better neurological recovery, which could be mediated through the immunomodulatory activity of M2 macrophages.

title: Safety and therapeutic potential of M2-macrophages in XXXX treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: OBJECTIVE: The aim of the present study was to clarify the relationship between the stand-up test and gait speed, @entity626 ( @entity571 ), and @entity170 using calcaneal quantitative ultrasound. STUDY DESIGN: Cross-sectional study. METHODS: A total of 185 subjects (55 @entity1 , 130 @entity1 ) aged >= 40 years (mean age, 63.7 years; range, 40-79 years) were evaluated using the stand-up test to screen for @entity426 . We also assessed @entity571 of the knee using X-rays and a subjective questionnaire, physical characteristics, 6-m gait speed (m/s), and bone density. If results on the stand-up test were worse than benchmarks by age group (i.e., the height at which 50% of each age group could stand-up), the subject was defined as having a risk for @entity426 (L group). We analyzed the relationship between the stand-up test and other variables. RESULTS: Of 185 subjects, 50 (27.0%) were classified into the L group. In univariate analysis, there were significant differences between the L group and non-L group in bone density (p  <  0.001), gait speed (p  <  0.001), @entity170 (p  <  0.001), @entity73 ( @entity73 ) (cut off 1  m/s), and Japanese @entity626 measure score. Multivariate logistic regression analysis adjusted for age, height, weight, and gender showed a significant association between the stand-up test and bone density (OR 0.960, 95% confidence interval (95% CI) 0.927-0.994), gait speed (m/s) (OR 0.073, 95% CI 0.016-0.342), @entity170 (OR 3.710, 95% CI 1.410-9.764), and @entity73 (OR 7.849, 95% CI 1.628-37.845). CONCLUSIONS: The stand-up test to screen for the risk for @entity426 was associated with bone density, gait speed, @entity170 , @entity73 . The stand-up test is an easy test to use to screen for possible disability among the elderly.

title: Relation between the stand-up test and gait speed, XXXX , and @entity170 using calcaneal quantitative ultrasound - Cross-sectional study.

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['knee osteoarthritis']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['SGSG', 'slow gait speed group']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity426 :: ('MESH:D020233', 'Disease') :: ['locomotive syndrome']

answer: @entity626 :: (MESH:D020370,Disease) :: ['knee osteoarthritis']


abstract: OBJECTIVE: The aim of the present study was to clarify the relationship between the stand-up test and gait speed, @entity626 ( @entity571 ), and @entity170 using calcaneal quantitative ultrasound. STUDY DESIGN: Cross-sectional study. METHODS: A total of 185 subjects (55 @entity1 , 130 @entity1 ) aged >= 40 years (mean age, 63.7 years; range, 40-79 years) were evaluated using the stand-up test to screen for @entity426 . We also assessed @entity571 of the knee using X-rays and a subjective questionnaire, physical characteristics, 6-m gait speed (m/s), and bone density. If results on the stand-up test were worse than benchmarks by age group (i.e., the height at which 50% of each age group could stand-up), the subject was defined as having a risk for @entity426 (L group). We analyzed the relationship between the stand-up test and other variables. RESULTS: Of 185 subjects, 50 (27.0%) were classified into the L group. In univariate analysis, there were significant differences between the L group and non-L group in bone density (p  <  0.001), gait speed (p  <  0.001), @entity170 (p  <  0.001), @entity73 ( @entity73 ) (cut off 1  m/s), and Japanese @entity626 measure score. Multivariate logistic regression analysis adjusted for age, height, weight, and gender showed a significant association between the stand-up test and bone density (OR 0.960, 95% confidence interval (95% CI) 0.927-0.994), gait speed (m/s) (OR 0.073, 95% CI 0.016-0.342), @entity170 (OR 3.710, 95% CI 1.410-9.764), and @entity73 (OR 7.849, 95% CI 1.628-37.845). CONCLUSIONS: The stand-up test to screen for the risk for @entity426 was associated with bone density, gait speed, @entity170 , @entity73 . The stand-up test is an easy test to use to screen for possible disability among the elderly.

title: Relation between the stand-up test and gait speed, @entity626 , and XXXX using calcaneal quantitative ultrasound - Cross-sectional study.

answer: @entity170 :: (MESH:D010024,Disease) :: ['osteoporosis']


abstract: UNASSIGNED: A 58-year-old @entity1 with a history of a heavy @entity285 intake was admitted to hospital for a 3-weeks history of abdominal discomfort, @entity390 , @entity391 and an increased abdominal girth that appeared progressively after an @entity1661 due to an @entity2332 . On physical examination, @entity1087 was present and the abdomen was distended with no tenderness on palpation. Laboratory studies showed an increased white-cell count, an elevated @entity1851 and abnormal liver-function tests. Abdominal ultrasonography showed a large fluid collection in the right side of the abdomen. An abdominal computed tomography scan revealed a @entity1085 perforation communicating to a big subcapsular hepatic biloma of 9.5 by 25.0 by 35.0 centimeters, which was compressing the liver and other intraabdominal organs. Finally, our @entity1 underwent an open cholecystectomy with @entity5173 , and a partial resection of the Glisson's capsule. Macroscopic and microscopic examination of the resected specimens confirmed the diagnosis of @entity1085 perforation. Gallbladder @entity130 is a rare entity. The diagnosis represents a challenge because of its low incidence, its association with other lesions of vital organs and the nonspecific and insidious symptoms that can produce. Treatment depends on the type and severity of the damage caused; nevertheless, cholecystectomy remains the treatment of choice in @entity1 with @entity397 or @entity155 of the @entity1085 . To our knowledge, this is the first report in the English literature of an isolated blunt @entity130 that was associated with the development of a large biloma.

title: Giant biloma as a result of a blunt XXXX : A case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity1085 :: ('MESH:D005705', 'Disease') :: ['traumatic gallbladder', 'gallbladder']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic injury', 'traumatic gallbladder injury']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal trauma']

entities_list: @entity5173 :: ('MESH:D065634', 'Disease') :: ['drainage of the biloma']

entities_list: @entity155 :: ('MESH:D014084', 'Disease') :: ['avulsion']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['accidental fall']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity1661 :: (MESH:D000008,Disease) :: ['abdominal trauma']


abstract: OBJECTIVES: We had for aim to determine the risk factors for acquiring @entity2893 -intermediate or -resistant Gram-negative bacilli (CR-GNB) in an intensive care unit (ICU) and to identify the resistance mechanisms involved. @entity1 AND METHODS: We conducted an observational prospective cohort study during 6 months in medical and surgical ICUs of the Besan  on Teaching Hospital. @entity1 with acquired CR-GNB were @entity1 whose cultures (screening or diagnosis) became positive more than 48h after admission to the ICU. The risk factors for ICU-acquired CR-GNB were determined by multivariate logistic regression. CR-GNB isolates were typed by pulsed-field gel electrophoresis (PFGE) and screened for resistance mechanisms with phenotypic and genotypic tests. RESULTS: Twenty-three of the 347 included @entity1 had acquired a CR-GNB. The multivariate analysis revealed significant associations between this acquisition and the duration of previous treatments with @entity3400 - @entity7120 (adjusted odds ratio [aOR], 1.13, P=0.02) and @entity581 (aOR, 1.62; P=0.005), but not with carbapenems. The CR-GNB strains were identified as @entity796 (n=10), @entity14346 (n=7), and @entity7100 (n=6). No acquired carbapenemase-producing strain was identified. PFGE typing identified 1 multiple clone among @entity796 isolates (4 @entity1 ), whereas for the other bacteria, all the strains were different. CONCLUSION: Our study results suggest that the strategy to prevent the emergence and spread of CR-GNB should not be limited to the sole restriction of @entity2893 use in ICU settings.

title: Acquisition of XXXX -resistant Gram-negative bacilli in intensive care unit: Predictors and molecular epidemiology.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity796 :: ('287', 'Species') :: ['Pseudomonas aeruginosa', 'P.  aeruginosa']

entities_list: @entity14346 :: ('40324', 'Species') :: ['Stenotrophomonas maltophilia']

entities_list: @entity7120 :: ('MESH:C043265', 'Chemical') :: ['tazobactam']

entities_list: @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['carbapenem']

entities_list: @entity581 :: ('MESH:D000617', 'Chemical') :: ['aminoglycosides']

entities_list: @entity3400 :: ('MESH:D010878', 'Chemical') :: ['piperacillin']

entities_list: @entity7100 :: ('550', 'Species') :: ['Enterobacter cloacae']

answer: @entity2893 :: (CHEBI:46765,Chemical) :: ['carbapenem']


abstract: UNASSIGNED: The main goal of this work was to study the effect of Aurora kinase expression on cell ploidy and tumorigenesis. Fifty invasive @entity0 , 50 diffuse large @entity1892 and 10 reactive lymph node samples were recruited in the study. Because of the significant correlation with the overall cell proliferation rate, the overexpression of @entity16511 could not be stated on the basis of kinase expressing @entity5 cell fractions alone. The relative expression of @entity16511 kinase is better reflected by the AMI index which represents the @entity16511 expression in relation to the whole proliferative fraction of the @entity5 . A higher relative @entity16511 expression was associated with higher mitotic activity in @entity1892 . FISH analysis of the @entity16511 locus did not show any gains or amplifications in the samples analyzed. On the other hand, we have observed the loss of the gene in @entity0 and @entity706 samples as well. A strong correlation was shown between @entity16511 and @entity876 copy numbers: @entity16511 loss was associated with @entity876 deletion in all samples. According to our results on @entity0 , losses at 17p13.1 and chromosome 17 aneusomy determined by FISH showed a statistically significant correlation. Our study presents the frequent occurrence of chromosome 17 aneusomy in @entity0 and @entity1892 samples. Chromosome 17 aneusomy evaluated by FISH correlated with @entity2007 determined by flow cytometry. Direct correlation between kinase expression and ploidy could not be shown. The highest AMI values were seen in B-ALCL samples, and it was associated with high chromosome 17 copy numbers and mitotic activity. The damaged @entity16511 kinase function results in @entity942 in the CPC complex leading to @entity2246 , while @entity876 deficiency helps malignant cells to survive due to insufficient activation of the intrinsic apoptotic pathways. The upregulation of @entity16511 function may cause error in an important mitotic checkpoint, thus resulting in induction of aneuploid cell populations. These parallel effects finally increase the complexity of @entity854 and generate aneuploid cell populations.

title: [Biologic mechanisms of XXXX and chromosome number changes in @entity5 ].

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast carcinoma', 'breast cancer']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma']

entities_list: @entity16511 :: ('9212', 'Gene') :: ['AURKB', 'Aurora B', 'Aurora kinase B']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['mitotic abnormalities']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['regulatory deficiencies']

entities_list: @entity2246 :: ('MESH:D008661', 'Disease') :: ['mitotic errors']

answer: @entity854 :: (MESH:D018376,Disease) :: ['mitotic abnormalities']


abstract: UNASSIGNED: The main goal of this work was to study the effect of Aurora kinase expression on cell ploidy and tumorigenesis. Fifty invasive @entity0 , 50 diffuse large @entity1892 and 10 reactive lymph node samples were recruited in the study. Because of the significant correlation with the overall cell proliferation rate, the overexpression of @entity16511 could not be stated on the basis of kinase expressing @entity5 cell fractions alone. The relative expression of @entity16511 kinase is better reflected by the AMI index which represents the @entity16511 expression in relation to the whole proliferative fraction of the @entity5 . A higher relative @entity16511 expression was associated with higher mitotic activity in @entity1892 . FISH analysis of the @entity16511 locus did not show any gains or amplifications in the samples analyzed. On the other hand, we have observed the loss of the gene in @entity0 and @entity706 samples as well. A strong correlation was shown between @entity16511 and @entity876 copy numbers: @entity16511 loss was associated with @entity876 deletion in all samples. According to our results on @entity0 , losses at 17p13.1 and chromosome 17 aneusomy determined by FISH showed a statistically significant correlation. Our study presents the frequent occurrence of chromosome 17 aneusomy in @entity0 and @entity1892 samples. Chromosome 17 aneusomy evaluated by FISH correlated with @entity2007 determined by flow cytometry. Direct correlation between kinase expression and ploidy could not be shown. The highest AMI values were seen in B-ALCL samples, and it was associated with high chromosome 17 copy numbers and mitotic activity. The damaged @entity16511 kinase function results in @entity942 in the CPC complex leading to @entity2246 , while @entity876 deficiency helps malignant cells to survive due to insufficient activation of the intrinsic apoptotic pathways. The upregulation of @entity16511 function may cause error in an important mitotic checkpoint, thus resulting in induction of aneuploid cell populations. These parallel effects finally increase the complexity of @entity854 and generate aneuploid cell populations.

title: [Biologic mechanisms of @entity854 and chromosome number changes in XXXX ].

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignant tumors']


abstract: UNASSIGNED: Predicting unfavorable outcome is of paramount importance in clinical decision making. Accordingly, we designed this multinational study, which provided the largest case series of @entity1906 ( @entity1906 ). 43 centers from 14 countries (Albania, Croatia, Denmark, Egypt, France, Hungary, Iraq, Italy, Macedonia, Romania, Serbia, Slovenia, Syria, @entity233 ) submitted data of microbiologically confirmed @entity1906 @entity1 hospitalized between 2000 and 2012. Unfavorable outcome was defined as survival with significant sequela or @entity204 . In developing our index, binary logistic regression models were constructed via 200 replicates of database by bootstrap resampling methodology. The final model was built according to the selection frequencies of variables. The severity scale included variables with arbitrary scores proportional to predictive powers of terms in the final model. The final model was internally validated by bootstrap resampling. A total of 507 @entity1 ' data were submitted among which 165 had unfavorable outcome. Eighty-six @entity1 died while 119 had different neurological sequelae in 79 (16  %) @entity1 . The full model included 13 variables. Age, @entity390 , @entity391 , altered consciousness, @entity1276 , @entity1333 , immunosuppression, @entity6 and @entity51 remained in the final model. Scores 1-3 were assigned to the variables in the severity scale, which included scores of 1-6. The distribution of mortality for the scores 1-6 was 3.4, 8.2, 20.6, 31, 30 and 40.1  %, respectively. @entity1662 , @entity6 , immunosuppression, @entity51 , @entity1276 , and @entity1333 predicted the unfavorable outcome in the scoring and the cumulative score provided a linear estimation of prognosis.

title: Hamsi scoring in the prediction of unfavorable outcomes from XXXX : results of Haydarpasa-II study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus']

entities_list: @entity1333 :: ('MESH:D014657', 'Disease') :: ['vasculitis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficits', 'neurological deficit']

entities_list: @entity1906 :: ('MESH:D014390', 'Disease') :: ['tuberculous meningitis', 'TBM']

entities_list: @entity1662 :: ('MESH:D003244', 'Disease') :: ['Altered consciousness']

answer: @entity1906 :: (MESH:D014390,Disease) :: ['tuberculous meningitis']


abstract: BACKGROUND: Mutations of @entity13019 , @entity18297 , @entity13027 , and @entity13030 genes are associated with @entity600 , including @entity2419 ( @entity3384 with @entity2419 ) in @entity1 . However, the source of Wnt ligands and their signaling effects on the orofacial morphogenetic process remain elusive. RESULTS: Using @entity4011 -Cre to impair Wnt secretion through the inactivation of @entity26467 /mWls, we investigate the relevant regulation of Wnt production and signaling in nasal-facial development. Ectodermal ablation of @entity26467 leads to severe @entity154 resulting from dramatically reduced cell proliferation and increased cell death due to a combined loss of WNT, FGF and @entity6861 signaling in the developing facial prominence. In the invaginating nasal pit, the @entity26467 disruption also causes a detrimental effect on migration of the olfactory epithelial cells into the mesenchymal region. The blockage of Wnt secretion apparently impairs the olfactory epithelial cells through modulation of @entity4675 signaling. CONCLUSIONS: Our study thus suggests the head ectoderm, including the facial ectoderm and the neuroectoderm, as the source of canonical as well as non-canonical Wnt ligands during early development of the nasal-facial prominence. Both @entity3546 dependent and independent signaling pathways are required for proper development of these morphogenetic processes. This article is protected by copyright. All rights reserved.

title: Ectodermal Wnt controls nasal pit morphogenesis through modulation of the XXXX /FGF/ @entity4675 signaling axis.

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['facial deformities']

entities_list: @entity2419 :: ('MESH:D002972', 'Disease') :: ['cleft palate', 'nonsyndromic CLP']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['orofacial birth defects']

answer: @entity6861 :: (649,Gene) :: ['BMP']


abstract: BACKGROUND: Mutations of @entity13019 , @entity18297 , @entity13027 , and @entity13030 genes are associated with @entity600 , including @entity2419 ( @entity3384 with @entity2419 ) in @entity1 . However, the source of Wnt ligands and their signaling effects on the orofacial morphogenetic process remain elusive. RESULTS: Using @entity4011 -Cre to impair Wnt secretion through the inactivation of @entity26467 /mWls, we investigate the relevant regulation of Wnt production and signaling in nasal-facial development. Ectodermal ablation of @entity26467 leads to severe @entity154 resulting from dramatically reduced cell proliferation and increased cell death due to a combined loss of WNT, FGF and @entity6861 signaling in the developing facial prominence. In the invaginating nasal pit, the @entity26467 disruption also causes a detrimental effect on migration of the olfactory epithelial cells into the mesenchymal region. The blockage of Wnt secretion apparently impairs the olfactory epithelial cells through modulation of @entity4675 signaling. CONCLUSIONS: Our study thus suggests the head ectoderm, including the facial ectoderm and the neuroectoderm, as the source of canonical as well as non-canonical Wnt ligands during early development of the nasal-facial prominence. Both @entity3546 dependent and independent signaling pathways are required for proper development of these morphogenetic processes. This article is protected by copyright. All rights reserved.

title: Ectodermal Wnt controls nasal pit morphogenesis through modulation of the @entity6861 /FGF/ XXXX signaling axis.

answer: @entity4675 :: (5599,Gene) :: ['JNK']


abstract: UNASSIGNED: @entity463 ( @entity463 ) is the most aggressive @entity1313 , with 12-15 months median survival time despite current treatment efforts. Among the alternative treatment approaches that have gained acceptance over the last decade is the use of replication-competent oncolytic adenoviruses, which are promising due to their relatively low @entity137 and @entity5 -specific targeting. Three-dimensional (3D) @entity5 models can mimic the physiological microenvironment of @entity463 @entity5 and provide valuable information about the interaction between @entity5 cells and adenoviruses. Therefore, robust in vitro 3D @entity5 models are critical to investigate the mechanisms underlying @entity5 progression and explore the @entity137 effect of the adenovirus on @entity5 cells. In this study, we used a hydrogel microwell platform to generate in vitro 3D @entity463 spheroids and studied their interactions with the Delta-24-RGD adenovirus. The results showed that the cultured 3D spheroids were successfully infected by the Delta-24-RGD. A significant cell lysis was observed. Cell viability was decreased approximately 37%, 54% and 65% with 10, 50, and 100 MOIs, respectively. The infection of the Delta-24-RGD was found more effective on 3D spheroids when compared to 2D monolayer cell culture. These results implicate that our hydrogel microwell platform could provide a promising 3D model to investigate the oncolytic potential of the viruses in vitro.

title: Delta-24-RGD Induces XXXX Spheroids in Three Dimensional PEG Microwells.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['GBM', 'Glioblastoma']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumor']

answer: @entity137 :: (MESH:D064420,Disease) :: ['Cytotoxicity of Glioblastoma']


abstract: AIM: To elucidate the clinicopathological characteristics of clinically early @entity356 in the upper-third stomach and to clarify treatment precautions. METHODS: A total of 683 @entity1 with clinical early @entity356 were enrolled in this retrospective study, 128 of whom had @entity356 in the upper-third stomach (U group). All @entity1 underwent a double contrast barium examination, endoscopy, and computed tomography (CT), and were diagnosed preoperatively based on the findings obtained. The clinicopathological features of these @entity1 were compared with those of @entity1 with @entity356 in the middle- and lower-third stomach (ML group). We also compared clinicopathological factors between accurate-diagnosis and under-diagnosis groups in order to identify factors affecting the accuracy of a preoperative diagnosis of @entity5 depth. RESULTS: @entity1 in the U group were older (P = 0.029), had a higher ratio of males to females (P = 0.015), and had more histologically differentiated @entity5 (P = 0.007) than @entity1 in the ML group. A clinical under-diagnosis occurred in 57 out of 683 @entity1 (8.3%), and was more frequent in the U group than in the ML group (16.4% vs 6.3%, P < 0.0001). Therefore, the rates of lymph node @entity3 and lymphatic invasion were slightly higher in the U group than in the ML group (P = 0.071 and 0.082, respectively). An under-diagnosis was more frequent in histologically undifferentiated @entity5 (P = 0.094) and in those larger than 4 cm (P = 0.024). The median follow-up period after surgery was 56 mo (range, 1-186 mo). Overall, survival and disease-specific survival rates were significantly lower in the U group than in the ML group (P = 0.016 and 0.020, respectively). However, limited operation-related @entity5 recurrence was not detected in the U group in the present study. CONCLUSION: Clinical early @entity356 in the upper-third stomach has distinguishable characteristics that increase the risk of a clinical under-diagnosis, especially in @entity1 with larger or undifferentiated @entity5 .

title: Clinicopathological characteristics of clinical early XXXX in the upper-third stomach.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancer']


abstract: OBJECTIVE: To determine the most accurate, noninvasive method of assessing @entity2700 . STUDY DESIGN: The following data sources were searched: electronic databases, gray literature, scientific meetings, reference lists, and authors of unpublished studies. Eligible studies were comparative outpatient evaluations that used an accepted reference standard and were conducted in developed countries in @entity1 aged <18  years with @entity1902 . Data extraction was completed independently by multiple reviewers before a consensus was made. RESULTS: Nine studies that included 1039 @entity1 were identified. The 4-item @entity922 ( @entity922 ), the "Gorelick" score, and unstructured physician assessment were evaluated in 3, 2, and 5 studies, respectively. Bedside ultrasound, capillary digital videography, and urinary measurements were each evaluated in one study. The @entity922 had a positive likelihood ratio (LR) range of 1.87-11.79 and a negative LR range of 0.30-0.71 to predict 6% @entity2700 . When combined with the 4-item Gorelick Score, the positive LR was 1.93 (95% CI 1.07-3.49) and negative LR was of 0.40 (95% CI 0.24-0.68). Unstructured @entity2700 assessment had a pooled positive LR of 2.13 (95% CI 1.33-3.44) and negative LR of 0.48 (95% CI 0.28-0.82) to detect >= 5% @entity2700 . CONCLUSIONS: Overall, the clinical scales evaluated provide some improved diagnostic accuracy. However, test characteristics indicate that their ability to identify @entity1 both with and without @entity2700 is suboptimal. Current evidence does not support the routine use of ultrasound or urinalysis to determine @entity2700 severity.

title: Diagnosing Clinically Significant Dehydration in XXXX with Acute Gastroenteritis Using Noninvasive Methods: A Meta-Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children']

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['CDS', 'Clinical Dehydration Scale']

entities_list: @entity2700 :: ('MESH:D003681', 'Disease') :: ['dehydration']

entities_list: @entity1902 :: ('MESH:D005759', 'Disease') :: ['gastroenteritis']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: Serum samples were obtained from 26 beef @entity291 with uterine prolapse and from 15 with minor @entity1266 (controls). The serum of animals with uterine prolapse had significantly lower @entity460 concentration (mean +/- S.D. = 8,22 +/- 0,69 mg/dL, P</=0,01), higher @entity3151 concentration (mean +/- S.D. = 4,78 +/- 1,75 mg/dL, P</=0,05) and lower @entity460 to @entity3151 ratios (mean +/- S.D. = 1,99 +/- 0,88, P</=0,01) than for the control animals (means +/- S.D. = 8,91 +/- 0,75 mg/dL, 3,54 +/- 1,41 mg/dL and 2,99 +/- 1,41 respectively). Mild @entity3747 (6,9 mg/dL-7,9 mg/dL) was present in 11 (42,3%) of the @entity291 with prolapse as compared to only one (6,7%) of the controls. @entity5886 was present in 11 (42,3%) of the animals with prolapse and in ten (66,7%) of the controls. Eighteen (69,2%) of the animals with prolapse were alert and ambulatory when treated and 15 (57,7%) were known to have required help to deliver the @entity291 . Of the @entity291 group with uterine prolapse, 14 (53,8%) were two years old, six (23,1%) were three years old, and six (23,1%) were four years of age or older. It was concluded that mild @entity3747 and some degree of @entity1266 were associated with the uterine prolapses. The @entity3151 results were equivocal but the high incidence of @entity5886 may reflect a @entity3151 deficient diet.

title: Observations on uterine prolapse in beef XXXX .

entities_list: @entity3747 :: ('MESH:D006996', 'Disease') :: ['hypocalcemia']

entities_list: @entity5886 :: ('MESH:D017674', 'Disease') :: ['Hypophosphatemia', 'hypophosphatemia']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']

answer: @entity291 :: (9913,Species) :: ['cattle']


abstract: UNASSIGNED: To improve the efficacy of transcatheter arterial chemoembolization (TACE) for @entity157 ( @entity157 ), this study evaluated the prevalence and causes of extrahepatic arteries (EHAs) and identified feeding arteries in HCCs in three independent clinical groups in a single inverventional radiology center. Between November 2011 and September 2012, 942 cases of @entity157 were included in this retrospective study. The @entity1 were treated in three independent groups of 285, 301 and 356 @entity1 , respectively. Enhanced computed tomography, enhanced magnetic resonance imaging and digital subtraction angiography were reviewed retrospectively and correlations between the presence of @entity5 -feeding EHAs and @entity5 number, size and location in the liver, number of repeat TACE procedures and complications were assessed. There were 698 EHAs in the 942 cases of @entity157 , with 182, 233 and 283 EHAs in the three independent groups, respectively. @entity5 size was associated with EHA formation; the percentages of @entity1 with EHAs were 2.7  3.0, 5.5  0.5, 43.2  4.0, 61.8  5.2 and 93.4  1.8% with @entity5 sizes of 2-3, 3-5, 5-7, 7-9 and >9 cm, respectively. There were 159  19 EHAs in each group feeding @entity5 in peripheral locations in the liver, but only 48.7  6.8 in the central zone. The most common EHA was the @entity7244 , with a mean of 101.0  14.1 per group. The number of EHAs increased proportionally with the number of TACE sessions. The number of EHAs was positively associated with @entity5 size, peripheral location of the @entity5 and number of TACE sessions.

title: Evaluation of extrahepatic collateral arteries in XXXX in three independent groups in a single center.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

entities_list: @entity7244 :: ('MESH:D020765', 'Disease') :: ['right inferior phrenic artery']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatocellular carcinoma']


abstract: Fifty-seven @entity1 with @entity2971 (GCTs) treated at our center between 1962 and 1979 were evaluated to determine 1) the prognostic value of disease stage, @entity5 histology, primary site, and @entity1 age; 2) results of therapy; and 3) patterns of @entity3 . The 35 @entity1 and 22 @entity1 were from 1 week to 18 years old (median 5 yr). Primary sites were ovarian (20), testicular (10), sacrococcygeal (12), retroperitoneal (7), mediastinal (5), and other (3). Cox regression analysis indicated that stage was the most important prognostic variable. @entity5 were usually advanced at diagnosis, but @entity5 site did not have prognostic value independent of disease stage. Neither @entity1 age nor @entity5 histology significantly influenced outcome. Drugs active against malignant GCTs included @entity1891 , @entity786 , and @entity4316 in combination and @entity5713 , @entity1732 , and @entity900 . Radiation alone cured nondisseminated @entity3438 . The most common sites of @entity3 were lungs, liver, central nervous system, and bone; other sites were infrequently involved. We conclude that stage was the most important prognostic variable, extragonadal @entity5 were usually advanced at diagnosis, and similarities in the histogenesis, metastatic pattern, and response to therapy, regardless of primary site, justify the consideration of childhood malignant GCTs as one group.

title: XXXX in 57 @entity1 and adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'girls', 'boys']

entities_list: @entity2971 :: ('MESH:D009373', 'Disease') :: ['malignant germ cell tumors']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Extragonadal tumors', 'tumors']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cis-platinum']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity4316 :: ('MESH:D003609', 'Chemical') :: ['dactinomycin']

entities_list: @entity3438 :: ('MESH:D018237', 'Disease') :: ['germinomas']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

entities_list: @entity1732 :: ('MESH:D001761', 'Chemical') :: ['bleomycin']

entities_list: @entity5713 :: ('MESH:D014747', 'Chemical') :: ['vinblastine']

answer: @entity2971 :: (MESH:D009373,Disease) :: ['Malignant germ cell tumors']


abstract: Fifty-seven @entity1 with @entity2971 (GCTs) treated at our center between 1962 and 1979 were evaluated to determine 1) the prognostic value of disease stage, @entity5 histology, primary site, and @entity1 age; 2) results of therapy; and 3) patterns of @entity3 . The 35 @entity1 and 22 @entity1 were from 1 week to 18 years old (median 5 yr). Primary sites were ovarian (20), testicular (10), sacrococcygeal (12), retroperitoneal (7), mediastinal (5), and other (3). Cox regression analysis indicated that stage was the most important prognostic variable. @entity5 were usually advanced at diagnosis, but @entity5 site did not have prognostic value independent of disease stage. Neither @entity1 age nor @entity5 histology significantly influenced outcome. Drugs active against malignant GCTs included @entity1891 , @entity786 , and @entity4316 in combination and @entity5713 , @entity1732 , and @entity900 . Radiation alone cured nondisseminated @entity3438 . The most common sites of @entity3 were lungs, liver, central nervous system, and bone; other sites were infrequently involved. We conclude that stage was the most important prognostic variable, extragonadal @entity5 were usually advanced at diagnosis, and similarities in the histogenesis, metastatic pattern, and response to therapy, regardless of primary site, justify the consideration of childhood malignant GCTs as one group.

title: @entity2971 in 57 XXXX and adolescents.

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: In May 2012, there were increasing @entity294 cases and deaths reported from Nabua, Camarines Sur to the Philippines event-based surveillance system. An investigation was conducted to identify risk factors and determine transmission dynamics. METHODS: A suspected case was defined as a resident of Nabua with at least three episodes of watery @entity294 per day from 16 March to 22 June 2012. A confirmed case was defined as a suspected case positive for @entity1838 . An environmental investigation was conducted and rectal swabs and water samples sent to the national reference laboratory for bacterial isolation. A 1:2 case-control study matching for age and sex was conducted. Data were analysed using Epi Info. RESULTS: There were 309 suspected cases with two deaths, and the most affected age group was @entity1 under five years (45%). Eight cases were positive for @entity1838 Ogawa El Tor and one for Non-01. Water samples were positive for faecal coliforms and @entity3752 . The case-control study showed that cases had a higher odds than controls of using unchlorinated water sources (odds ratio [OR]  =  3.6; 95% confidence interval [CI]:1.6-8.5) and having toilets located within 20 m of a septic tank (OR  =  2.7; 95% CI: 1.4-5.3). In multivariate analysis, the only significant factor was drinking from piped water (OR  =  0.21; 95% CI: 0.09-0.49). DISCUSSION: In this @entity3081 outbreak, drinking-water from unchlorinated wells was a significant risk factor. Future @entity3081 control efforts should include not just improving water and sanitation systems but also intensified behaviour change campaigns.

title: Availability of safe drinking-water: the answer to XXXX outbreak? Nabua, Camarines Sur, Philippines, 2012.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity1838 :: ('666', 'Species') :: ['Vibrio cholerae']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhoea']

entities_list: @entity3752 :: ('648', 'Species') :: ['Aeromonas caviae']

answer: @entity3081 :: (MESH:D002771,Disease) :: ['cholera']


abstract: INTRODUCTION: Opponensplasty is a surgical option for @entity1 with severe @entity923 ( @entity923 ). We investigated prognostic factors of @entity1 lacking preoperative compound muscle action potential (CMAP) of the abductor pollicis brevis (APB) muscle to determine the necessity for single-stage opponensplasty. METHODS: We retrospectively enrolled 22 hands of 22 @entity923 @entity1 . Prognostic factors considered were age, @entity6 , the median sensory nerve action potential, distal motor latency of the second lumbrical (2L) CMAP (2L-DML), and its amplitude (2L-Amp). Postoperative APB-CMAP amplitude (post APB-Amp) at 12 months was used as the outcome measure. RESULTS: Only 2L-DML showed a significant correlation with post APB-Amp (r = -0.56). The contribution of 2L-Amp was not significant, although 3 hands with absent 2L-CMAP had a poor electrophysiological recovery. DISCUSSION: Prolonged 2L-DML and absent 2L-CMAP seem to be poor prognostic factors. Concurrent opponensplasty may not be necessary in @entity1 with 2L-DML of 8 ms or less. This article is protected by copyright. All rights reserved.

title: Prognosis of severe XXXX with absent compound muscle action potential.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity923 :: ('MESH:D002349', 'Disease') :: ['carpal tunnel syndrome', 'CTS']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

answer: @entity923 :: (MESH:D002349,Disease) :: ['carpal tunnel syndrome']


abstract: OBJECTIVES: We report in this singlecenter study our results of a five-year experience in the administration of @entity3303 spray (LS) during ultrasound-guided prostate biopsy (TPB). MATERIAL AND METHODS: Between August 2008 and July 2013 a total of 1022 consecutive male @entity1 scheduled for TPB with elevate PSA (>=  4 ng/ml) and (or) abnormal digital rectal and (or) suspect TRUS were considered eligible for the study. Each @entity1 was treated under local anaesthesia with LS (10 gr/100 ml), applied two minutes before the procedure. TPB was performed with the @entity1 in the left lateral decubitus using multi-frequency convex probe "end-fire". Two experienced urologists performed a 14-core biopsy, as first intention. After the procedure each @entity1 was given a verbal numeric @entity158 scale (VNS). The evaluation was differentiated in two scales VNS: VNS 1 for the insertion of the probe and the manoeuvres associated, while VNS 2 only for the @entity158 during needle's insertion. RESULTS: @entity158 scores were not statistically significant different with regard to the values of PSA and prostate gland volume. @entity158 score levels during probe insertion and biopsy were significantly different: the mean @entity158 score according to VNS was 3.3 (2-8) in the first questionnaire (VNS1) (p < 0.001) and 2.1 (1-7) in the second one (VNS2) (p < 0.125). The 8.2% of cases referred severe or unbearable @entity158 (score >=  7), 74% of @entity1 referred no @entity158 at all. Only 21 @entity1 would not ever repeat the biopsy or would request a different type of anaesthesia, while 82% of them would repeat it in the same way. In only eight @entity1 we have not been able to insert TRUS probe. CONCLUSIONS: Our @entity158 score data suggest that LS provides efficient @entity1 comfort during TPB reducing @entity158 both during insertion of the probe and the needle. This non-infiltrative anaesthesia is safe, easy to administer, psychologically well accepted by @entity1 and of low cost.

title: XXXX spray administration in transrectal ultrasound-guided prostate biopsy: Five years of experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

answer: @entity3303 :: (MESH:D008012,Chemical) :: ['Lidocaine']


abstract: OBJECTIVES: To investigate the effect of stretch-and-flow voice therapy on vocal function and handicap. STUDY DESIGN: Randomized controlled trial. METHODS: @entity1 with primary @entity121 dysphonia were randomly assigned to experimental or control groups. Experimental @entity1 received vocal hygiene education followed by 6 weeks of stretch-and-flow voice therapy. Control @entity1 received vocal hygiene education only. Outcome variables consisted of a measure of @entity1032 (Voice Handicap Index [VHI]), maximum phonation time, s/z ratio, and acoustic measures. All measures were obtained at baseline prior to treatment and within 2 weeks posttreatment or at the end of the control period. The pre- to posttreatment measurement change (delta   ) was applied to statistical analyses. RESULTS: A multivariate analysis of variance revealed significant group differences in pre-to-post changes on measures of VHI, maximum phonation time, and cepstral peak prominence (CPP) in connected speech and vowels (P   =   0.003, 0.013, 0.025, and 0.017 respectively), with a significant reduction of VHI (Cohen's d   =   1.6), increase in maximum phonation time (Cohen's d   =   1.2), increase of CPP in connected speech (Cohen's d   =   1.2), and increase of CPP in vowels (Cohen's d   =   1.1) in the experimental group compared to the control group. CONCLUSIONS: This preliminary small sample randomized controlled trial found significantly greater improvement in @entity1032 , maximum phonation time, and acoustic measures of vocal function after @entity1 received stretch-and-flow voice therapy compared to @entity1 receiving vocal hygiene education alone. Additional research incorporating larger samples will be needed to confirm and further investigate these findings. LEVEL OF EVIDENCE: 1b. Laryngoscope, 2015.

title: A randomized controlled trial of stretch-and-flow voice therapy for XXXX Dysphonia.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['vocal handicap']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle tension']

answer: @entity121 :: (MESH:D009135,Disease) :: ['muscle tension']