abstract: PURPOSE: The aim of this study was to compare the efficacy and side effects of @entity12356 1% versus @entity11074 0.1% after Descemet membrane endothelial keratoplasty (DMEK). METHODS: DMEK recipients used @entity12356 1% for 1 month, and they were randomized to either @entity617 or @entity11074 for months 2 through 12. Dosing was 4 times daily in months 1 to 3, thrice daily in month 4, twice daily in month 5, and once daily in months 6 to 12. The main outcomes were immunologic rejection episodes and intraocular pressure (IOP) elevation (defined as >= 24 mm Hg or >= 10 mm Hg increase over the preoperative baseline level), assessed by the Kaplan-Meier survival analysis. RESULTS: The study included 325 eyes (99% were white, 96% had @entity13189 , and 9% had a previous @entity726 diagnosis). No eyes (0%) assigned to @entity617 versus 2 eyes (1.4%) assigned to @entity11074 experienced a possible (n = 1) or probable (n = 1) rejection episode (P = 0.17). Both rejection episodes resolved successfully with increased topical @entity230 . In the @entity617 arm, a significantly higher proportion exceeded the defined IOP elevation threshold (22% vs. 6%, P = 0.0005), and @entity726 medications were initiated or increased more often (17% vs. 5%, P = 0.0003). The most frequent reasons for discontinuing the assigned intervention were IOP management (n = 13 eyes assigned to @entity617 ) or @entity32 management (n = 3 eyes assigned to @entity11074 ). One-year endothelial cell loss was comparable in both arms (30% vs. 31%, P = 0.50). CONCLUSIONS: DMEK has a remarkably low rejection episode rate (<1% through 1 year), as confirmed in this prospective randomized study. This provides a unique opportunity to reduce postoperative topical corticosteroid strength and thereby reduce the risk of @entity134 -associated complications.

title: Randomized comparison of topical XXXX 1% versus @entity11074 0.1% in the first year after descemet membrane endothelial keratoplasty.

answer: @entity12356 :: (MESH:C009935,Chemical) :: ['prednisolone acetate']


abstract: CONTEXT: Exerting a broad range of biological effects in various tissues, activins are homo- or heterodimers of activin/inhibin b-subunits (bA, bB, bC, and bE in @entity1 ). Although activins A (bAbA), B (bBbB), @entity12440 (bAbB), and AC (bAbC) have been demonstrated in the female reproductive system, little is known about their individual functions in the ovary. OBJECTIVE: To investigate the biological roles and activities of activins in regulating steroidogenesis in @entity1 granulosa cells. DESIGN: @entity1 granulosa-lutein cells obtained from 32 @entity1 undergoing in vitro fertilization were used to investigate the effects of activin A, B, @entity12440 , and AC on the expression of steroidogenic enzymes and @entity134 production. SETTING: An academic research center. MAIN OUTCOME MEASURES: mRNA and protein levels were examined by reverse transcription quantitative real-time PCR and Western blot analysis, respectively. The production of @entity53 and @entity1420 was measured by enzyme immunoassay. RESULTS: P450 aromatase, @entity23385 , and @entity53 levels were increased, whereas @entity624 ( @entity624 ), @entity10548 , and @entity1420 levels were decreased after treatment with activin A, B, and @entity12440 , but not activin AC. FSH or LH induced the production of aromatase/ @entity53 and @entity624 / @entity1420 ; however, pretreatment with activin A, B, or @entity12440 enhanced the effects of gonadotropins on aromatase/ @entity53 , but suppressed their effects on @entity624 / @entity1420 . Treatment with activin A, B, or @entity12440 induced the phosphorylation of SMA- and MAD-related proteins ( @entity14877 ), whereas activin AC had no such effects. Furthermore, co-culture of activin AC (1-100 ng/mL) with activin A (25 ng/mL) did not alter the effects of activin A on P450 aromatase or @entity624 mRNA levels. CONCLUSION: Activin A, B, and @entity12440 have similar effects on steroidogenesis in @entity1 granulosa cells. In contrast, activin AC is not biologically active and does not act as a competitive antagonist.

title: Effects of recombinant activins on steroidogenesis in XXXX granulosa-lutein cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human', 'patients', 'Human']

entities_list: @entity624 :: ('6770', 'Gene') :: ['StAR', 'steroidogenic acute regulatory protein']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Background: In contrast to @entity794 -derived superantigenic exotoxins, the role of non-superantigenic exotoxins in the pathogenesis of eosinophilic @entity1030 remains obscure. We sought to characterize @entity794 alpha-toxin-induced cellular responses in chronic rhinosinusitis with @entity480 (CRSwNP). Methods: Dispersed nasal polyp cells and uncinate tissue cells were prepared from @entity1 with @entity91 with and without @entity480 , respectively. Cells were incubated with various concentrations of alpha-toxin or staphylococcal enterotoxin B and then the levels of IL-5, IL-13, IFN-y, IL-17A, and @entity688 in the cell supernatants were determined. The pathophysiological significance of alpha-toxin-induced cytokine production was also determined including radiological severity of rhinosinusitis, tissue and blood @entity1712 , serum total IgE level, and 1-s forced expiratory volume/forced vital capacity ratio (FEV1/FVC). Results: Nasal polyp cells produced substantial amounts of IL-5, IL-13, IFN-y, IL-17A, and @entity688 in response to alpha-toxin. Cytokine production was higher in nasal polyp cells than in uncinate tissue cells. The potency of alpha-toxin in stimulating IL-5, IL-13, and @entity688 production was comparable to that of @entity11765 . Alpha-toxin-induced IFN-y, IL-17A, and @entity688 production significantly and negatively correlated with the degree of eosinophil infiltration into @entity480 . Conversely, alpha-toxin-induced IFN-y and @entity688 production significantly and positively correlated with FEV1/FVC. @entity688 production was significantly lower in @entity748 @entity1 compared to non-asthmatics Conclusions: @entity794 -derived alpha-toxin can provoke cellular responses in @entity480 . These responses, especially failure to synthesize @entity688 , may play a role in the pathophysiology of CRSwNP.

title: Cellular Responses to @entity794 Alpha-Toxin in Chronic Rhinosinusitis with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus', 'S. aureus']

entities_list: @entity11765 :: ('MESH:D004768', 'Chemical') :: ['enterotoxin']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['airway diseases']

entities_list: @entity480 :: ('MESH:D009298', 'Disease') :: ['nasal polyps']

answer: @entity480 :: (MESH:D009298,Disease) :: ['Nasal Polyps']


abstract: Background: In contrast to @entity794 -derived superantigenic exotoxins, the role of non-superantigenic exotoxins in the pathogenesis of eosinophilic @entity1030 remains obscure. We sought to characterize @entity794 alpha-toxin-induced cellular responses in chronic rhinosinusitis with @entity480 (CRSwNP). Methods: Dispersed nasal polyp cells and uncinate tissue cells were prepared from @entity1 with @entity91 with and without @entity480 , respectively. Cells were incubated with various concentrations of alpha-toxin or staphylococcal enterotoxin B and then the levels of IL-5, IL-13, IFN-y, IL-17A, and @entity688 in the cell supernatants were determined. The pathophysiological significance of alpha-toxin-induced cytokine production was also determined including radiological severity of rhinosinusitis, tissue and blood @entity1712 , serum total IgE level, and 1-s forced expiratory volume/forced vital capacity ratio (FEV1/FVC). Results: Nasal polyp cells produced substantial amounts of IL-5, IL-13, IFN-y, IL-17A, and @entity688 in response to alpha-toxin. Cytokine production was higher in nasal polyp cells than in uncinate tissue cells. The potency of alpha-toxin in stimulating IL-5, IL-13, and @entity688 production was comparable to that of @entity11765 . Alpha-toxin-induced IFN-y, IL-17A, and @entity688 production significantly and negatively correlated with the degree of eosinophil infiltration into @entity480 . Conversely, alpha-toxin-induced IFN-y and @entity688 production significantly and positively correlated with FEV1/FVC. @entity688 production was significantly lower in @entity748 @entity1 compared to non-asthmatics Conclusions: @entity794 -derived alpha-toxin can provoke cellular responses in @entity480 . These responses, especially failure to synthesize @entity688 , may play a role in the pathophysiology of CRSwNP.

title: Cellular Responses to XXXX Alpha-Toxin in Chronic Rhinosinusitis with @entity480 .

answer: @entity794 :: (1280,Species) :: ['Staphylococcus aureus']


abstract: Abstract Rapid identification of @entity2075 following closed @entity542 represents a significant health care need because of the potentially life-threatening risk they present. This study demonstrates the clinical utility of an index of brain electrical activity used to identify intracranial @entity1410 in @entity131 ( @entity131 ) presenting to the @entity341 ( @entity341 ). Brain electrical activity was recorded from a limited montage located on the forehead of 394 closed head injured @entity1 who were referred for CT scans as part of their standard @entity341 assessment. A total of 116 of these @entity1 were found to be CT positive (CT+), of which 46 @entity1 with @entity2075 (CT+) were identified for study. A total of 278 @entity1 were found to be CT negative (CT-) and were used as controls. CT scans were subjected to quanitative measurements of volume of blood and distance of bleed from recording electrodes by blinded independent experts, implementing a validated method for @entity1410 measurement. Using an algorithm based on brain electrical activity developed on a large independent cohort of @entity131 @entity1 and controls ( @entity131 -Index), @entity1 were classified as either positive or negative for structural @entity1545 . Sensitivity to @entity1410 was found to be 95.7% (95% CI=85.2, 99.5), specificity was 43.9% (95% CI=38.0, 49.9). There was no significant relationship between the @entity131 -Index and distance of the bleed from recording sites (F=0.044, p=0.833), or volume of blood measured F=0.179, p=0.674). Results of this study are a validation and extension of previously published retrospective findings in an independent population, and provide evidence that a @entity131 -Index for structural @entity1545 is a highly sensitive measure for the detection of potentially life-threatening @entity2075 , and could contribute to the rapid, quantitative evaluation and treatment of such @entity1 .

title: Identification of @entity1410 in Mild XXXX Using an Index of Quantitative Brain Electrical Activity.

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injury']

entities_list: @entity1410 :: ('MESH:D006406', 'Disease') :: ['hematomas', 'hematoma']

entities_list: @entity2075 :: ('MESH:D020198', 'Disease') :: ['traumatic intracranial hematomas']

answer: @entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']


abstract: Abstract Rapid identification of @entity2075 following closed @entity542 represents a significant health care need because of the potentially life-threatening risk they present. This study demonstrates the clinical utility of an index of brain electrical activity used to identify intracranial @entity1410 in @entity131 ( @entity131 ) presenting to the @entity341 ( @entity341 ). Brain electrical activity was recorded from a limited montage located on the forehead of 394 closed head injured @entity1 who were referred for CT scans as part of their standard @entity341 assessment. A total of 116 of these @entity1 were found to be CT positive (CT+), of which 46 @entity1 with @entity2075 (CT+) were identified for study. A total of 278 @entity1 were found to be CT negative (CT-) and were used as controls. CT scans were subjected to quanitative measurements of volume of blood and distance of bleed from recording electrodes by blinded independent experts, implementing a validated method for @entity1410 measurement. Using an algorithm based on brain electrical activity developed on a large independent cohort of @entity131 @entity1 and controls ( @entity131 -Index), @entity1 were classified as either positive or negative for structural @entity1545 . Sensitivity to @entity1410 was found to be 95.7% (95% CI=85.2, 99.5), specificity was 43.9% (95% CI=38.0, 49.9). There was no significant relationship between the @entity131 -Index and distance of the bleed from recording sites (F=0.044, p=0.833), or volume of blood measured F=0.179, p=0.674). Results of this study are a validation and extension of previously published retrospective findings in an independent population, and provide evidence that a @entity131 -Index for structural @entity1545 is a highly sensitive measure for the detection of potentially life-threatening @entity2075 , and could contribute to the rapid, quantitative evaluation and treatment of such @entity1 .

title: Identification of XXXX in Mild @entity131 Using an Index of Quantitative Brain Electrical Activity.

answer: @entity1410 :: (MESH:D006406,Disease) :: ['Hematomas']


abstract: @entity9463 iowae, an occasional pathogen of @entity233 , was isolated for the first time from captive grey partridges (Perdix perdix). Clinical signs including respiratory and @entity1944 were seen in birds of all ages but mainly in those kept housed during rearing. Mortality rates averaged over 20% during the year. Treatment with antibiotics and antiparasitic drugs produced only a transient improvement in condition. The gross pathology findings included poor body growth, lack of development of the breast muscles, abnormalities in the keel development, and @entity79 . Some birds showed infraorbital @entity1244 with serous or fibrinous exudates and @entity6062 , while others presented serofibrinous airsacculitis and @entity381 . Laboratory investigations revealed pure cultures of M. iowae in the gut as well as sinus and air sacs. While other organisms such as coccidia, Trichomonas, @entity526 , @entity3168 , and Aspergillus spp. were detected, the similarity of the disease with that seen in @entity233 infected with M. iowae strongly suggests that this @entity9463 may be the primary pathogen here. The presence of M. iowae in game birds commonly released into the wild could have serious implications particularly in areas where industrial poultry farms are concentrated.

title: First isolation of XXXX iowae in grey partridge flocks.

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']

entities_list: @entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal disorder']

entities_list: @entity9463 :: ('MESH:D009175', 'Disease') :: ['mycoplasma', 'Mycoplasma']

entities_list: @entity6062 :: ('MESH:D014136', 'Disease') :: ['catarrhal tracheitis']

entities_list: @entity3168 :: ('1502', 'Species') :: ['Clostridium perfringens']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone fragility']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity9463 :: (MESH:D009175,Disease) :: ['Mycoplasma']


abstract: PURPOSE: The appendix can be a rare cause for chronic right lower quadrant @entity490 (RLQAP), even though no objective disorder can be determined to the appendix. This condition can be described as @entity102 . After careful selection, elective appendectomy is performed in our centre for this group of @entity1 . METHODS: All @entity1 that underwent an elective appendectomy between 2006 and 2013 were prospectively analysed. Inclusion criterion was chronic RLQAP without abnormalities seen on imaging. Exclusion criterion was @entity158 after conservative treatment of (complicated) @entity698 or an abnormal appendix on imaging like a mass, mucocoele or faecolith. Primary outcome was the effect on the @entity158 postoperatively. RESULTS: In the period of the study, ten @entity1 met the inclusion criteria and underwent an appendectomy for chronic RLQAP. Average preoperative @entity158 score assessed with visual analogue scale (VAS) was 8.6. Preoperative work-up showed no abnormalities. No @entity854 were seen during surgery in any of the @entity1 . Histopathological analysis was obtained and showed @entity854 in eight of ten @entity1 , mostly suspicion of previous @entity32 . Postoperatively, no complications occurred, and at revision after 3 weeks, average VAS was 1.0. Long-term follow-up showed that @entity1 remained free of symptoms; average VAS after a median of 33 months was 1.0. CONCLUSIONS: A significant @entity158 was achieved after an appendectomy in all @entity1 suffering from chronic RLQAP in this series. Seven out of ten @entity1 were completely free of @entity158 .

title: Laparoscopic appendectomy for chronic right lower quadrant XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity698 :: ('MESH:D001064', 'Disease') :: ['appendicitis']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic appendicitis or (neurogenic) appendicopathy']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['limited abnormalities', 'macroscopic abnormalities']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['reduction of pain', 'pain']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

answer: @entity490 :: (MESH:D015746,Disease) :: ['abdominal pain']


abstract: WHAT IS KNOWN AND OBJECTIVE: The risk of dosage @entity910 ( @entity910 ) among manually written prescriptions within 'mixed' prescribing system (computerized physician order entry (CPOE)  +  manual prescriptions) has not been previously assessed in neonatology. This study aimed to evaluate the rate of dosage @entity910 related to manual prescriptions in the high-risk population of very preterm @entity1 (GA  <  33  weeks) in a mixed prescription system. METHODS: The study was based on a retrospective review of a random sample of manual daily prescriptions in two neonatal intensive care units (NICU) A and B, located in different French University hospitals (Dijon and La Reunion island). Daily prescription was defined as the set of all drugs manually prescribed on a single day for one @entity1 . Dosage error was defined as a deviation of at least   10% from the weight-appropriate recommended dose. RESULTS AND DISCUSSION: The analyses were based on the assessment of 676 manually prescribed drugs from NICU A (58 different drugs from 93 newborns and 240 daily prescriptions) and 354 manually prescribed drugs from NICU B (73 different drugs from 131 newborns and 241 daily prescriptions). The dosage error rate per 100 manually prescribed drugs was similar in both NICU: 3  8% (95% CI: 2  5-5  6%) in NICU A and 3  1% (95% CI: 1  6-5  5%) in NICU B (P  =  0  54). Among all the 37 identified dosage errors, the over-dosing was almost as frequent as the under-dosing (17 and 20 errors, respectively). Potentially severe dosage errors occurred in a total of seven drug prescriptions. None of the dosage @entity910 was recorded in the corresponding medical files and information on clinical outcome was not sufficient to identify clinical conditions related to dosage @entity910 . Overall, 46  8% of manually prescribed drugs were off label or unlicensed, with no significant differences between prescriptions with or without dosage error. The risk of a dosage @entity910 increased significantly if the drug was included in the CPOE system but was manually prescribed (OR  =  3  3; 95% CI: 1  6-7  0, P  <  0  001). WHAT IS NEW AND CONCLUSION: The presence of dosage @entity910 in the manual prescriptions written within mixed prescription systems suggests that manual prescriptions should be totally avoided in neonatal units.

title: Frequency of dosage prescribing medication errors associated with manual prescriptions for very preterm XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['infants', 'patient']

entities_list: @entity910 :: ('MESH:D004409', 'Disease') :: ['Prescription Medication Error', 'PME']

answer: @entity1 :: (9606,Species) :: ['infants']


abstract: OBJECTIVES: To review outcomes of the treatment of @entity2735 ( @entity2735 ) of the penis at a large supra-regional @entity5 network, where centralisation has permitted greater experience with treatment outcomes, and suggest treatment strategies. @entity1 AND METHODS: The network @entity5 database, which details presentation, treatment and complications was analysed from 2003 to 2010, identifying @entity1 with @entity2735 , with a minimum follow-up of 2 years, looking at treatments administered and outcomes. RESULTS: In all, 57 @entity1 with mean (range) age of 61 (34-91) years were identified. In all, 18 were treated by circumcision only, 20 by circumcision and local excision (LE) and 19 by circumcision and 5-flurouracil ( @entity1487 ). The mean (range) follow-up was 3.5 (2-8) years. Of those treated by circumcision none subsequently developed @entity2735 on the glans. For those who underwent circumcision + LE, five of 20 (25%) developed recurrence requiring further treatment. Of those treated by circumcision + @entity1487 , 14/19 (73.7%) completely responded. Of the five incomplete responders, two had focal invasive @entity5 at repeat biopsy. One incomplete responder underwent glansectomy and four grafting. No complete responders relapsed. Complications of @entity1487 included significant inflammatory response in seven (36.8%), with two requiring hospital admission and one neo-phimosis (5.3%). CONCLUSION: This study suggests that @entity1 undergoing circumcision for isolated @entity2735 and complete responders to @entity1487 may require only short-term follow-up, as recurrence is unlikely, whereas longer follow up is required for all other @entity1 . However, numbers in this study are small and larger studies are needed to support this. An incomplete response to @entity1487 dictates immediate re-biopsy, as it carries a significant chance of previously undetected invasive disease.

title: The treatment of penile XXXX ( @entity2735 ) within a UK supra-regional network.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['penile cancer', 'malignancy']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity2735 :: ('MESH:D002278', 'Disease') :: ['CIS', 'carcinoma in situ']

answer: @entity2735 :: (MESH:D002278,Disease) :: ['carcinoma in situ']


abstract: OBJECTIVES: To review outcomes of the treatment of @entity2735 ( @entity2735 ) of the penis at a large supra-regional @entity5 network, where centralisation has permitted greater experience with treatment outcomes, and suggest treatment strategies. @entity1 AND METHODS: The network @entity5 database, which details presentation, treatment and complications was analysed from 2003 to 2010, identifying @entity1 with @entity2735 , with a minimum follow-up of 2 years, looking at treatments administered and outcomes. RESULTS: In all, 57 @entity1 with mean (range) age of 61 (34-91) years were identified. In all, 18 were treated by circumcision only, 20 by circumcision and local excision (LE) and 19 by circumcision and 5-flurouracil ( @entity1487 ). The mean (range) follow-up was 3.5 (2-8) years. Of those treated by circumcision none subsequently developed @entity2735 on the glans. For those who underwent circumcision + LE, five of 20 (25%) developed recurrence requiring further treatment. Of those treated by circumcision + @entity1487 , 14/19 (73.7%) completely responded. Of the five incomplete responders, two had focal invasive @entity5 at repeat biopsy. One incomplete responder underwent glansectomy and four grafting. No complete responders relapsed. Complications of @entity1487 included significant inflammatory response in seven (36.8%), with two requiring hospital admission and one neo-phimosis (5.3%). CONCLUSION: This study suggests that @entity1 undergoing circumcision for isolated @entity2735 and complete responders to @entity1487 may require only short-term follow-up, as recurrence is unlikely, whereas longer follow up is required for all other @entity1 . However, numbers in this study are small and larger studies are needed to support this. An incomplete response to @entity1487 dictates immediate re-biopsy, as it carries a significant chance of previously undetected invasive disease.

title: The treatment of penile @entity2735 ( XXXX ) within a UK supra-regional network.

answer: @entity2735 :: (MESH:D002278,Disease) :: ['CIS']


abstract: We investigated whether the @entity1262 @entity7658 polymorphism is associated with @entity3923 ( @entity3923 ), infiltrating @entity0 (IDBC), and/or clinical-pathological features of IDBC in Mexican @entity1 . Samples from @entity1 who received surgical treatment in 2007 at the Centro M  dico de Occidente (M  xico) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 @entity982 -embedded breast samples with IDBC, 64 samples with @entity3923 , and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the @entity3923 , IDBC, and HG samples, respectively. Significant differences were only found between the @entity3923 and HG samples [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24% for @entity3923 , IDBC, and HG samples, respectively. Again, statistical differences were only found between @entity3923 and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the @entity7658 polymorphism and clinical-pathological features of the IDBC group. Both the @entity3923 and IDBC groups had a high frequency of the C allele relative to the HG in this sample of @entity1 from Western Mexico.

title: @entity1262 @entity7658 polymorphism in Mexican @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['ductal breast cancer']

entities_list: @entity3923 :: ('MESH:D005348', 'Disease') :: ['fibrocystic changes', 'FCC']

entities_list: @entity982 :: ('MESH:D010232', 'Chemical') :: ['paraffin']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: We investigated whether the @entity1262 @entity7658 polymorphism is associated with @entity3923 ( @entity3923 ), infiltrating @entity0 (IDBC), and/or clinical-pathological features of IDBC in Mexican @entity1 . Samples from @entity1 who received surgical treatment in 2007 at the Centro M  dico de Occidente (M  xico) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 @entity982 -embedded breast samples with IDBC, 64 samples with @entity3923 , and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the @entity3923 , IDBC, and HG samples, respectively. Significant differences were only found between the @entity3923 and HG samples [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24% for @entity3923 , IDBC, and HG samples, respectively. Again, statistical differences were only found between @entity3923 and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the @entity7658 polymorphism and clinical-pathological features of the IDBC group. Both the @entity3923 and IDBC groups had a high frequency of the C allele relative to the HG in this sample of @entity1 from Western Mexico.

title: XXXX @entity7658 polymorphism in Mexican @entity1 with @entity0 .

answer: @entity1262 :: (5243,Gene) :: ['MDR1']


abstract: We investigated whether the @entity1262 @entity7658 polymorphism is associated with @entity3923 ( @entity3923 ), infiltrating @entity0 (IDBC), and/or clinical-pathological features of IDBC in Mexican @entity1 . Samples from @entity1 who received surgical treatment in 2007 at the Centro M  dico de Occidente (M  xico) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 @entity982 -embedded breast samples with IDBC, 64 samples with @entity3923 , and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the @entity3923 , IDBC, and HG samples, respectively. Significant differences were only found between the @entity3923 and HG samples [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24% for @entity3923 , IDBC, and HG samples, respectively. Again, statistical differences were only found between @entity3923 and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the @entity7658 polymorphism and clinical-pathological features of the IDBC group. Both the @entity3923 and IDBC groups had a high frequency of the C allele relative to the HG in this sample of @entity1 from Western Mexico.

title: @entity1262 XXXX polymorphism in Mexican @entity1 with @entity0 .

answer: @entity7658 :: (c|SUB|C|3435|T,DNAMutation) :: ['C3435T']


abstract: We investigated whether the @entity1262 @entity7658 polymorphism is associated with @entity3923 ( @entity3923 ), infiltrating @entity0 (IDBC), and/or clinical-pathological features of IDBC in Mexican @entity1 . Samples from @entity1 who received surgical treatment in 2007 at the Centro M  dico de Occidente (M  xico) were included in the analysis. Genotyping was performed by polymerase chain reaction-restricted fragment length polymorphisms in 64 @entity982 -embedded breast samples with IDBC, 64 samples with @entity3923 , and 183 peripheral blood samples of healthy females designated as the healthy group (HG). The frequency of the T allele was 41, 45, and 52% for the @entity3923 , IDBC, and HG samples, respectively. Significant differences were only found between the @entity3923 and HG samples [odds ratio (OR) = 0.64, 95% confidence interval (CI) = 0.43-0.96; P = 0.032]. The prevalence of the T/T genotype was 8, 13, and 24% for @entity3923 , IDBC, and HG samples, respectively. Again, statistical differences were only found between @entity3923 and HG samples for the T/T genotype (OR = 0.28, 95%CI = 0.106-0.77; P = 0.009). Although the T allele and the T/T genotype were less frequent in the IDBC group than in the HG, the differences were not significant. Furthermore, no associations were found between the @entity7658 polymorphism and clinical-pathological features of the IDBC group. Both the @entity3923 and IDBC groups had a high frequency of the C allele relative to the HG in this sample of @entity1 from Western Mexico.

title: @entity1262 @entity7658 polymorphism in Mexican XXXX with @entity0 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: IgG4-related @entity4578 and @entity7841 (IgG4-DS) is characterized by serum IgG4 elevation and the infiltration of IgG4-positive plasma cells in glandular tissues. For definitive diagnosis of IgG4-DS, biopsies of @entity75 are recommended to exclude @entity244 ( @entity244 ), @entity5 , and similar disorders. In this study, we examined the diagnostic utility of submandibular gland (SMG) and labial salivary gland (LSG) biopsies in IgG4-DS. Fourteen @entity1 presenting with swelling of the SMG (eight females and six males) underwent both SMG and LSG biopsies. The sensitivity, specificity, and accuracy of SMG biopsies were all 100.0%. In contrast, those of LSG biopsies were 69.2%, 100.0%, and 71.4%, respectively. Thirty-three out of 61 LSG biopsies (54.1%) from all 14 @entity1 were positive for the diagnostic criteria of IgG4-DS (IgG4-positive/IgG-positive plasma cells >0.4). None of the @entity1 experienced complications such as @entity2103 , sialocele, or hyposalivation. The IgG4/IgG ratio showed no significant correlation between the LSG and SMG. The final diagnosis was IgG4-DS in 13 @entity1 and @entity1892 ( @entity1892 ) in one. These results suggest that incisional biopsy of the SMG is useful and appropriate for the definitive diagnosis of IgG4-DS, while diagnosis by LSG biopsy alone requires more caution.

title: The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related XXXX and @entity7841 , so-called Mikulicz's disease.

entities_list: @entity7841 :: ('MESH:D012793', 'Disease') :: ['sialoadenitis']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['local lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumours']

entities_list: @entity2103 :: ('MESH:D005155', 'Disease') :: ['facial nerve palsy']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['marginal zone B-cell lymphoma', 'MZL']

entities_list: @entity244 :: ('MESH:D014899', 'Disease') :: ["Sj  gren's syndrome", 'SS']

entities_list: @entity4578 :: ('MESH:D003607', 'Disease') :: ['dacryoadenitis']

answer: @entity4578 :: (MESH:D003607,Disease) :: ['dacryoadenitis']


abstract: IgG4-related @entity4578 and @entity7841 (IgG4-DS) is characterized by serum IgG4 elevation and the infiltration of IgG4-positive plasma cells in glandular tissues. For definitive diagnosis of IgG4-DS, biopsies of @entity75 are recommended to exclude @entity244 ( @entity244 ), @entity5 , and similar disorders. In this study, we examined the diagnostic utility of submandibular gland (SMG) and labial salivary gland (LSG) biopsies in IgG4-DS. Fourteen @entity1 presenting with swelling of the SMG (eight females and six males) underwent both SMG and LSG biopsies. The sensitivity, specificity, and accuracy of SMG biopsies were all 100.0%. In contrast, those of LSG biopsies were 69.2%, 100.0%, and 71.4%, respectively. Thirty-three out of 61 LSG biopsies (54.1%) from all 14 @entity1 were positive for the diagnostic criteria of IgG4-DS (IgG4-positive/IgG-positive plasma cells >0.4). None of the @entity1 experienced complications such as @entity2103 , sialocele, or hyposalivation. The IgG4/IgG ratio showed no significant correlation between the LSG and SMG. The final diagnosis was IgG4-DS in 13 @entity1 and @entity1892 ( @entity1892 ) in one. These results suggest that incisional biopsy of the SMG is useful and appropriate for the definitive diagnosis of IgG4-DS, while diagnosis by LSG biopsy alone requires more caution.

title: The diagnostic utility of biopsies from the submandibular and labial salivary glands in IgG4-related @entity4578 and XXXX , so-called Mikulicz's disease.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity7841 :: (MESH:D012793,Disease) :: ['sialoadenitis']


abstract: PURPOSE: To study the correlation between the @entity227 ( @entity227 ) and wide-field fundus autofluorescence (FAF) in @entity1 with @entity6391 ( @entity6391 ). DESIGN: Retrospective, observational, consecutive case series. METHODS: Twenty-four eyes of 12 @entity1 diagnosed with @entity6391 were enrolled. The VFs measured by Goldmann perimetry and wide-field FAF images were compared for each eye. The relationship between the areas of hypoautofluorescence on the wide-field FAF images and @entity1019 on Goldmann perimetry were evaluated. The @entity227 and FAF images in the central 60 degrees were trimmed and superimposed to calculate the percentage agreement between the hypoautofluorescence and the @entity1019 and between the isoautofluorescence and hyperautofluorescence and the remaining VFs. RESULTS: The areas of hypoautofluorescence on the FAF images were correlated significantly (R  = 0.86, P < .001) with the areas of the @entity227 on Goldmann perimetry. The mean percentage agreement between the hypoautofluorescence and the @entity1019 was 91.0%    7.7% and that of the isoautofluorescence and hyperautofluorescence with the remaining VFs was 84.5%    7.4%. The areas of geographic hypoautofluorescence with or without hyperautofluorescent bands reflected the @entity227 , while nummular or mottled hypoautofluorescence without @entity227 was seen in 7 eyes. CONCLUSIONS: These results suggested that wide-field FAF imaging is useful to evaluate the remaining retinal function in @entity1 with @entity6391 . Abnormal fundus autofluorescence precedes @entity989 and is helpful for monitoring disease progression.

title: Wide-Field Fundus Autofluorescence Imaging to Evaluate Retinal Function in @entity1 With XXXX .

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['VF defects', 'visual fields', 'VF']

entities_list: @entity6391 :: ('MESH:D012174', 'Disease') :: ['retinitis pigmentosa', 'RP']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['loss of retinal function']

entities_list: @entity1019 :: ('MESH:D012607', 'Disease') :: ['scotomas', 'scotoma']

answer: @entity6391 :: (MESH:D012174,Disease) :: ['Retinitis Pigmentosa']


abstract: PURPOSE: To study the correlation between the @entity227 ( @entity227 ) and wide-field fundus autofluorescence (FAF) in @entity1 with @entity6391 ( @entity6391 ). DESIGN: Retrospective, observational, consecutive case series. METHODS: Twenty-four eyes of 12 @entity1 diagnosed with @entity6391 were enrolled. The VFs measured by Goldmann perimetry and wide-field FAF images were compared for each eye. The relationship between the areas of hypoautofluorescence on the wide-field FAF images and @entity1019 on Goldmann perimetry were evaluated. The @entity227 and FAF images in the central 60 degrees were trimmed and superimposed to calculate the percentage agreement between the hypoautofluorescence and the @entity1019 and between the isoautofluorescence and hyperautofluorescence and the remaining VFs. RESULTS: The areas of hypoautofluorescence on the FAF images were correlated significantly (R  = 0.86, P < .001) with the areas of the @entity227 on Goldmann perimetry. The mean percentage agreement between the hypoautofluorescence and the @entity1019 was 91.0%    7.7% and that of the isoautofluorescence and hyperautofluorescence with the remaining VFs was 84.5%    7.4%. The areas of geographic hypoautofluorescence with or without hyperautofluorescent bands reflected the @entity227 , while nummular or mottled hypoautofluorescence without @entity227 was seen in 7 eyes. CONCLUSIONS: These results suggested that wide-field FAF imaging is useful to evaluate the remaining retinal function in @entity1 with @entity6391 . Abnormal fundus autofluorescence precedes @entity989 and is helpful for monitoring disease progression.

title: Wide-Field Fundus Autofluorescence Imaging to Evaluate Retinal Function in XXXX With @entity6391 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: @entity788 in @entity1 is extremely rare. Here we present a female @entity1 with a mature cystic @entity44 of the pancreatic body. The @entity1 was admitted for a palpable abdominal mass and @entity448 . Computed tomography (CT) indicated a huge @entity3928 in the abdominal cavity. Exploratory laparotomy was performed, and the @entity5 was excised completely. Pathology confirmed the @entity5 was a mature cystic @entity44 of pancreatic origin. Two months after the initial surgery, a pseudocyst was detected and then cystojejunostomy was performed. Fourteen months after the second surgery, @entity5 relapse occurred and distal pancreatectomy was performed. The @entity1 remained well without @entity5 recurrence during the next 24 months of follow-up. Our experience suggests that clinical manifestations of @entity1 with @entity788 might be nonspecific and preoperative diagnosis is difficult. @entity5 resection and maximized preservation of healthy pancreatic tissue should always be balanced in surgical treatment.

title: XXXX of the pancreas: clinical presentation, evaluation and management.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'infant', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cystic teratomas', 'Pancreatic cystic teratoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Radical tumor']

entities_list: @entity3928 :: ('MESH:C536030', 'Disease') :: ['cystic mass']

entities_list: @entity448 :: ('MESH:D000855', 'Disease') :: ['anorexia']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratoma']

answer: @entity44 :: (MESH:D013724,Disease) :: ['Childhood cystic teratoma']


abstract: PURPOSE: To investigate the outcomes of @entity2249 in @entity1 with @entity4039 ( @entity4039 )-related impingement. METHODS: We retrospectively reviewed 37 consecutive @entity1 (40 hips; 19 male and 18 female @entity1 ; age range, 10 to 19  years) with @entity4039 who underwent hip arthroscopy for femoral neck osteoplasty over a 4-year period. Six hips were excluded because of the severity of the slip or conversion to an open procedure. The preoperative and postoperative slip angle, alpha angle, and internal rotation in flexion were compared. @entity1 were evaluated for @entity158 , functional limitations, and @entity717 ( @entity717 ) at each follow-up visit. The mean follow-up period was 22  months (range, 12 to 56  months). RESULTS: We analyzed the results of 34 hips. Adequate distraction could not be obtained initially in 7 hips. The labral and acetabular cartilage damage appeared to be from crushing and abrasion from the bony prominence of the neck. The goals of complete @entity158 relief and correction of @entity717 were achieved in 88% of the hips. @entity717 and @entity158 persisted in 2 hips, and 2 @entity1 had residual @entity158 despite good motion. There was a statistically significant improvement in alpha angle (from 88.22   and 56.91  , P < .0001) and internal rotation in flexion (from  -21.53   to 10.28  , P < .0001) with intervention. CONCLUSIONS: @entity2249 is effective in decreasing @entity158 , the alpha angle, and @entity717 in mild to moderate @entity4039 . @entity5845 , scarring from previous surgery, and the presence of screws in the anterior neck presented challenges to the arthroscopic technique. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

title: XXXX in @entity4039 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2249 :: ('MESH:D005265', 'Disease') :: ['Arthroscopic femoral neck osteoplasty', 'arthroscopic femoral neck osteoplasty']

entities_list: @entity5845 :: ('MESH:D009767', 'Disease') :: ['Morbid obesity']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['OERD', 'obligatory external rotation deformity']

entities_list: @entity4039 :: ('MESH:D060048', 'Disease') :: ['slipped capital femoral epiphysis', 'SCFE']

answer: @entity2249 :: (MESH:D005265,Disease) :: ['Arthroscopic femoral neck osteoplasty']


abstract: PURPOSE: To investigate the outcomes of @entity2249 in @entity1 with @entity4039 ( @entity4039 )-related impingement. METHODS: We retrospectively reviewed 37 consecutive @entity1 (40 hips; 19 male and 18 female @entity1 ; age range, 10 to 19  years) with @entity4039 who underwent hip arthroscopy for femoral neck osteoplasty over a 4-year period. Six hips were excluded because of the severity of the slip or conversion to an open procedure. The preoperative and postoperative slip angle, alpha angle, and internal rotation in flexion were compared. @entity1 were evaluated for @entity158 , functional limitations, and @entity717 ( @entity717 ) at each follow-up visit. The mean follow-up period was 22  months (range, 12 to 56  months). RESULTS: We analyzed the results of 34 hips. Adequate distraction could not be obtained initially in 7 hips. The labral and acetabular cartilage damage appeared to be from crushing and abrasion from the bony prominence of the neck. The goals of complete @entity158 relief and correction of @entity717 were achieved in 88% of the hips. @entity717 and @entity158 persisted in 2 hips, and 2 @entity1 had residual @entity158 despite good motion. There was a statistically significant improvement in alpha angle (from 88.22   and 56.91  , P < .0001) and internal rotation in flexion (from  -21.53   to 10.28  , P < .0001) with intervention. CONCLUSIONS: @entity2249 is effective in decreasing @entity158 , the alpha angle, and @entity717 in mild to moderate @entity4039 . @entity5845 , scarring from previous surgery, and the presence of screws in the anterior neck presented challenges to the arthroscopic technique. LEVEL OF EVIDENCE: Level IV, therapeutic case series.

title: @entity2249 in XXXX .

answer: @entity4039 :: (MESH:D060048,Disease) :: ['slipped capital femoral epiphysis']


abstract: BACKGROUND: @entity86 is a common complication in older adults, particularly after total joint replacement (arthroplasty). @entity911 after surgery can result in slower mobility progression, longer hospital stay, and increased @entity1 distress. @entity282 has been shown to be a risk factor related to @entity911 ; however, there is limited evidence regarding @entity158 level, medication use, and @entity911 development in postoperative arthroplasty @entity1 . PURPOSE: To evaluate development of postoperative @entity911 and the current practice of @entity158 management for older adult @entity1 with hip or knee arthroplasty. METHODS: Two-month retrospective chart review of medical records at a large, Midwestern, private hospital. @entity158 assessments were performed on a regular basis using self-report 11-point Numeric Rating Scale (0-10). Opioid use was scored using an equianalgesic conversion chart. RESULTS: Ninety-eight @entity1 met inclusion criteria and 97 received treatment with opioids during the first 48 hours postoperatively. No @entity1 received opioid agents that are contraindicated in older adults. Thirty-three @entity1 had evidence in the medical record of @entity911 during the first 48 hours postoperatively. Lower equianalgesic dose was significant for increased age and increased @entity911 on postoperative day 1 (POD 1) and POD 2. @entity1 with higher equianalgesic scores were less likely to meet benchmark @entity158 scores less than 5 on POD 0, POD 1, and POD 2. CONCLUSIONS: @entity1 receiving lower amounts of opioids in the first 48 hours after surgery were more likely to be confused on POD 1(p = .023) and POD 2 (p = .049).

title: @entity158 , opioids, and XXXX after arthroplasty in older adults.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion', 'Confusion']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['Postoperative confusion']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['Postoperative pain']

answer: @entity911 :: (MESH:D003221,Disease) :: ['confusion']


abstract: BACKGROUND: @entity86 is a common complication in older adults, particularly after total joint replacement (arthroplasty). @entity911 after surgery can result in slower mobility progression, longer hospital stay, and increased @entity1 distress. @entity282 has been shown to be a risk factor related to @entity911 ; however, there is limited evidence regarding @entity158 level, medication use, and @entity911 development in postoperative arthroplasty @entity1 . PURPOSE: To evaluate development of postoperative @entity911 and the current practice of @entity158 management for older adult @entity1 with hip or knee arthroplasty. METHODS: Two-month retrospective chart review of medical records at a large, Midwestern, private hospital. @entity158 assessments were performed on a regular basis using self-report 11-point Numeric Rating Scale (0-10). Opioid use was scored using an equianalgesic conversion chart. RESULTS: Ninety-eight @entity1 met inclusion criteria and 97 received treatment with opioids during the first 48 hours postoperatively. No @entity1 received opioid agents that are contraindicated in older adults. Thirty-three @entity1 had evidence in the medical record of @entity911 during the first 48 hours postoperatively. Lower equianalgesic dose was significant for increased age and increased @entity911 on postoperative day 1 (POD 1) and POD 2. @entity1 with higher equianalgesic scores were less likely to meet benchmark @entity158 scores less than 5 on POD 0, POD 1, and POD 2. CONCLUSIONS: @entity1 receiving lower amounts of opioids in the first 48 hours after surgery were more likely to be confused on POD 1(p = .023) and POD 2 (p = .049).

title: XXXX , opioids, and @entity911 after arthroplasty in older adults.

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: Abstract The surgical management of @entity4436 continues to evolve but recent literature has not qualified just how different current practice is compared with the previous @entity7971 . This study aims to update the seminal paper by Rodkey and Welch regarding indications and operation types performed for @entity4436 by comparing their findings with present practice at a community based institution. The charts of 407 @entity1 admitted with " @entity66 " between 2005 and 2010 were identified. For each admission, @entity1 ' demographics, presentations and management were recorded. Direct comparisons were made with results from the study by Rodkey and Welch. Of the 407 admissions studied, the distribution was 335 emergency and 72 elective. Medical management alone treated 90% of emergency admissions, while 4% required additional radiologic intervention. Emergency surgery was necessary in only 6% of cases with Hartmann's procedure being the most common procedure. Recurrent @entity4436 was a prime indication for elective surgery with 96% of cases undergoing a 1-staged procedure. Compared with the previous @entity7971 , the nonoperative approach to managing @entity697 is now applied for the vast majority of admissions. Improved success in medically temporizing @entity1 in the present @entity7971 has allowed for a higher percentage of successful single-staged elective surgeries.

title: Surgery for XXXX : a re-evaluation of the changing trends.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute diverticulitis']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['diverticular disease']

entities_list: @entity4436 :: ('MESH:D004238', 'Disease') :: ['diverticulitis']

answer: @entity4436 :: (MESH:D004238,Disease) :: ['diverticulitis']


abstract: OBJECTIVE: To assess the utility of the paraclinical tests in @entity1 presenting with clinical diagnosis of cervicogenic dizziness. STUDY DESIGN: Case controlled. SETTING: Otolaryngology clinic of a tertiary referral hospital center. @entity1 : Twenty-five subjects with cervicogenic dizziness and 25 subjects with benign paroxysmal positional vertigo. MAIN OUTCOME MEASURES: Symptoms description, @entity1296 Handicap Inventory-short form (DHI), Trait @entity148 score, cervical joint position error, the smooth pursuit neck torsion and cervical torsion tests on videonystagmography, and standing balance test (timed 10-meter walk with head turns). RESULTS: The results showed differences in reported symptoms, in mean cervical joint position error (p = 0.001), and cervical torsion test (p = 0.001) between the two groups. There was no between-group difference for DHI scores (p = 0.137), trait @entity148 scores (p = 0.240), and walking test: time (p = 0.797), steps (p = 0.963). The Youden index is 0.60 for the predictive value of the cervical joint position error, and the smooth pursuit and the cervical torsion tests. CONCLUSION: This study showed differences in sensorimotor disturbances between the two groups, particularly in the control of @entity1319 and cervical proprioception. @entity1 with cervicogenic dizziness were more likely to (1) have a sensation of @entity8769 and lightheadedness, (2) have @entity158 induced during the physical examination of the upper cervical vertebrae, (3) have an @entity2720 .5 degrees during the cervical relocation test, and (4) exhibit more than 2 degrees per second @entity346 during the cervical rotation test. The walking test was not able to differentiate the two groups.

title: Evaluation of Paraclinical Tests in the Diagnosis of Cervicogenic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity1319 :: ('MESH:D015835', 'Disease') :: ['head and eye movements']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['Dizziness']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['elevated joint position error of 4']

entities_list: @entity346 :: ('MESH:D009759', 'Disease') :: ['nystagmus']

entities_list: @entity8769 :: ('MESH:D000435', 'Disease') :: ['drunkenness']

answer: @entity1296 :: (MESH:D004244,Disease) :: ['Dizziness']


abstract: BACKGROUND: @entity955 is the most common @entity299 of @entity1378 . The association between history of @entity1378 and @entity64 remains unclear. We sought to determine whether history of @entity1374 is a @entity1031 risk factor in @entity1 with @entity955 . METHODS: @entity1 with @entity955 seen in an academic institution between 2000 and 2010 were identified and followed-up. Clinical events ( @entity64 , @entity548 , all-cause @entity204 ) were recorded and related to @entity1374 . Associations were examined in time-dependent models with adjustment for relevant confounders. RESULTS: Among 8962 @entity1 , 141 @entity1 had a history of @entity1378 , 540 had a history of @entity1375 , and 8271 had no @entity1374 . Mean follow-up was 929  1082 days. A total of 715 @entity64 /systemic @entity887 were recorded, with no significant difference in the rates of these events in @entity1 with a history of @entity1374 versus those without thyroid problems in either univariate or multivariable analysis (hazard ratio [HR] 0.85, 95% confidence interval [CI] 0.41-1.76 for @entity1378 ; HR 0.98, 95% CI 0.73-1.34 for @entity1375 ). There were 791 @entity548 events; history of @entity1375 was independently related to a higher rate of @entity548 events (HR 1.35, 95% CI 1.02-1.79). No significant difference between the 3 groups was observed for the incidence of @entity204 . CONCLUSIONS: History of @entity1378 was not an independent risk factor for @entity64 in @entity955 whereas @entity1375 was associated with a higher risk of @entity548 events. These data suggest no additional benefit from the inclusion of @entity1374 in @entity1031 models in @entity955 .

title: History of @entity1374 in Relation to Clinical Outcomes in XXXX : A Cohort Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke/systemic embolism', 'stroke']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolism']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic prediction', 'thromboembolic']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'Atrial fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac complication']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid status and disorders', 'thyroid dysfunction']

answer: @entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']


abstract: BACKGROUND: @entity955 is the most common @entity299 of @entity1378 . The association between history of @entity1378 and @entity64 remains unclear. We sought to determine whether history of @entity1374 is a @entity1031 risk factor in @entity1 with @entity955 . METHODS: @entity1 with @entity955 seen in an academic institution between 2000 and 2010 were identified and followed-up. Clinical events ( @entity64 , @entity548 , all-cause @entity204 ) were recorded and related to @entity1374 . Associations were examined in time-dependent models with adjustment for relevant confounders. RESULTS: Among 8962 @entity1 , 141 @entity1 had a history of @entity1378 , 540 had a history of @entity1375 , and 8271 had no @entity1374 . Mean follow-up was 929  1082 days. A total of 715 @entity64 /systemic @entity887 were recorded, with no significant difference in the rates of these events in @entity1 with a history of @entity1374 versus those without thyroid problems in either univariate or multivariable analysis (hazard ratio [HR] 0.85, 95% confidence interval [CI] 0.41-1.76 for @entity1378 ; HR 0.98, 95% CI 0.73-1.34 for @entity1375 ). There were 791 @entity548 events; history of @entity1375 was independently related to a higher rate of @entity548 events (HR 1.35, 95% CI 1.02-1.79). No significant difference between the 3 groups was observed for the incidence of @entity204 . CONCLUSIONS: History of @entity1378 was not an independent risk factor for @entity64 in @entity955 whereas @entity1375 was associated with a higher risk of @entity548 events. These data suggest no additional benefit from the inclusion of @entity1374 in @entity1031 models in @entity955 .

title: History of XXXX in Relation to Clinical Outcomes in @entity955 : A Cohort Study.

answer: @entity1374 :: (MESH:D013959,Disease) :: ['Thyroid Disorders']


abstract: The description of emission processes of volatile and semi-volatile organic compounds (VOCs and SVOCs) from building products requires a detailed understanding of the material and the air flow conditions at the surface boundary. The mass flux between the surface of the material and air depends on the mass transfer coefficient (hm) through the boundary layer, the gas phase concentration of the target compound immediately adjacent to the material (y0), and the gas-phase concentration in bulk air (y(t)). In the present study emission experiments were performed in two chambers of quite different sizes (0.25 m(3) and 55 m(3)), and, in the larger chamber, at two different temperatures (23  C and 30  C). The emitting material was latex wall paint that had been doped with two plasticizers, @entity26459 ( @entity13202 ) and @entity15523 ( @entity15524 ). The @entity5244 content in the paint was varied in the small chamber experiment to evaluate the impact of the initial concentration in the bulk material (C0) on the emission rate. Boundary layer theory was applied to calculate hm for the specific phthalates from the Sherwood number (Sh) and the diffusion coefficient (Dair). Then y0 was determined based on the bulk gas-phase concentration at steady state (y  ). For both, DEP and @entity15524 , the y0 obtained was lower than the respective saturation vapor pressure (Ps). Furthermore, for both @entity5600 in latex paint, the material/air partition coefficient (C0/y0) was close in value to the octanol/air partition coefficient (KOA). This study provides a basis for designing @entity5244 emitting reference materials that mimic the emission behavior of common building materials.

title: Latex paint as a delivery vehicle for XXXX and @entity15523 : predictable boundary layer concentrations and emission rates.

entities_list: @entity26459 :: ('MESH:C007379', 'Chemical') :: ['diethylphthalate']

entities_list: @entity5244 :: ('MESH:C032279', 'Chemical') :: ['phthalate']

entities_list: @entity5600 :: ('CHEBI:26092', 'Chemical') :: ['phthalates']

entities_list: @entity15523 :: ('MESH:D003993', 'Chemical') :: ['di-n-butylphthalate']

answer: @entity26459 :: (MESH:C007379,Chemical) :: ['diethylphthalate']


abstract: The description of emission processes of volatile and semi-volatile organic compounds (VOCs and SVOCs) from building products requires a detailed understanding of the material and the air flow conditions at the surface boundary. The mass flux between the surface of the material and air depends on the mass transfer coefficient (hm) through the boundary layer, the gas phase concentration of the target compound immediately adjacent to the material (y0), and the gas-phase concentration in bulk air (y(t)). In the present study emission experiments were performed in two chambers of quite different sizes (0.25 m(3) and 55 m(3)), and, in the larger chamber, at two different temperatures (23  C and 30  C). The emitting material was latex wall paint that had been doped with two plasticizers, @entity26459 ( @entity13202 ) and @entity15523 ( @entity15524 ). The @entity5244 content in the paint was varied in the small chamber experiment to evaluate the impact of the initial concentration in the bulk material (C0) on the emission rate. Boundary layer theory was applied to calculate hm for the specific phthalates from the Sherwood number (Sh) and the diffusion coefficient (Dair). Then y0 was determined based on the bulk gas-phase concentration at steady state (y  ). For both, DEP and @entity15524 , the y0 obtained was lower than the respective saturation vapor pressure (Ps). Furthermore, for both @entity5600 in latex paint, the material/air partition coefficient (C0/y0) was close in value to the octanol/air partition coefficient (KOA). This study provides a basis for designing @entity5244 emitting reference materials that mimic the emission behavior of common building materials.

title: Latex paint as a delivery vehicle for @entity26459 and XXXX : predictable boundary layer concentrations and emission rates.

answer: @entity15523 :: (MESH:D003993,Chemical) :: ['di-n-butylphthalate']


abstract: OBJECTIVE: To explore the methods and therapeutic effects of trans-fibular anterior-lateral approach combined with external fixation in the treatment of @entity174 . METHODS: From 2007 to 2010,9 @entity1 including 7 males and 2 females with the mean age of 40 years(ranging from 29 to 51 years). All @entity1 received internal fixation of fibula after debridement on the first phase, external fixator were used to fix tibia across ankle joint, and removed after successful skin graft; The second phase tibia was used to fix through the lateral incision used in phase I. Early functional exercise was encouraged ,the union condition and functional results of the ankle joint was evealuated. The criteria of the AOFAS Foot and Ankle Surgery was used to evaluate the effects. RESULTS: All @entity1 were followed up,and the duration ranged for 8 to 37 months(averaged 21 months). Nine @entity1 were achieved bony union, the average healing time was 24 weeks. No plate @entity397 was found. According to the AOFAS Foot and Ankle Surgery evaluation system, 3 cases got excellent results, 4 good cases and 2 fair. CONCLUSION: Trans-fibular anterior-lateral approach combined with external fixation for @entity174 can receive satisfactory reset, debond ankle joint eralier and imporove the clinical effects.

title: [Treatment of XXXX through trans-fibular anterior-lateral approach].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture or screw loosening']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['Gustilo III distal tibiofibula fractures']

answer: @entity174 :: (MESH:D050723,Disease) :: ['Gustilo III distal tibiofibula fractures']


abstract: OBJECTIVE: To compare therapeutic effects between suspine rotation and flexion manipulation for treating @entity890 . METHODS: From December 2008 to January 2011, 134 @entity1 with @entity890 were treated, including 74 males and 60 females,ranging in age from 17 to 67 years,33 @entity1 with age over 50 years old. According to diagnosis the ladder of the 9 cases bulging type, 74 hernia type, 51 cases free type. The @entity1 were randomly divided into treatment group ( 69 cases) and control group (65 cases). All the @entity1 were treated with the three-dimensional computer-controlled traction therapeutic apparatus,with continued traction for 20 minutes. After traction, flexion manipulation and rotat-ing manipulation were respectively adopted in treatment group and control group (on alternate days one time, 3 times as a course of treatment). The symptoms and signs (including back @entity158 and discomfort, lower limb @entity158 and @entity1183 , powerless urination and defecation, @entity1183 in perineum, straight-leg raising degree,ability of lower extremity walking,work and live) of @entity1 were observed after treatment. RESULTS: All @entity1 were followed up for 0.5 to 6 months with an average of 1.1 months. After treatment, the symptoms and signs of @entity1 have significantly improved (P < 0.01), but the symptomes of powerless urination and defecation, @entity1183 in perineum was not improved obviously (P>0.05). Forty-two of 69 @entity1 in treatment group got excellent result, moderate in 20, poor in 7; Twenty of 65 @entity1 in control group got excellent result, moderate in 25,poor in 20. CONCLUSION: The whole effect of lumbar backwards rotation manipulation is more satisfactory than flexsion manipulation for treating lumbar intervertebral disc herniation. But spinning force and times should be noticed.

title: [Case-control study on suspine rotation manipulation for the treatment of XXXX ].

entities_list: @entity890 :: ('MESH:D007405', 'Disease') :: ['lumbar disc herniation']

answer: @entity890 :: (MESH:D007405,Disease) :: ['lumbar disc herniation']


abstract: OBJECTIVE: To explore significance of preoperative @entity2996 ( @entity2996 ) for screening @entity1150 in @entity3140 . METHODS: From January 2009 to December 2011, 1200 @entity1 with @entity3140 caused by @entity130 were respectively analyzed. There were 833 males and 367 females,ranging from 20 to 78 (mean 41.94 +/- 15.41) years. All @entity1 had @entity4 and @entity158 in injured limbs when enrolled. @entity2996 was used to examine upper limbs vein at 3 to 10 d after improvement of @entity4 , 1 day before reduction. Relationship among occurrence of @entity715 , gender, age and @entity174 sites were analyzed. @entity1 with @entity11942 were analyzed with respective study to decide whether combined with @entity6 , @entity101 and @entity407 . RESULTS: All @entity1 were checked by @entity2996 ,which confirmed 9 cases with @entity11942 . The rate of @entity715 was 0.75%, @entity1 than @entity1 (P < 0.01). The risk of @entity4461 occurred over 30 years, and the occurrence of @entity715 in humerus @entity174 was higher than radius ulnar @entity174 . One of 9 @entity1 combined with @entity101 and @entity407 , 1 case combined with @entity6 , and 7 cases with no complication. CONCLUSION: Upper @entity174 may occur @entity1150 ; @entity2996 should be used to check @entity11942 in qualified hospital,which can maintain medical safety,decrease occurrence of medical disputes, and ganrantee @entity1 's safety.

title: [Significance of preoperative color doppler flow imaging for screening XXXX in @entity3140 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'patient', 'women', 'Patients', 'patients']

entities_list: @entity407 :: ('MESH:D006949', 'Disease') :: ['hyperlipidemia']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['trauma fracture', 'fracture']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['swelling']

entities_list: @entity2996 :: ('MESH:C564543', 'Disease') :: ['color Doppler flow imaging', 'CDFI']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity3140 :: ('MESH:D038062', 'Disease') :: ['upper limb fracture', 'upper limbs fracture']

entities_list: @entity4461 :: ('MESH:D020141', 'Disease') :: ['blood clots']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']


abstract: OBJECTIVE: To explore significance of preoperative @entity2996 ( @entity2996 ) for screening @entity1150 in @entity3140 . METHODS: From January 2009 to December 2011, 1200 @entity1 with @entity3140 caused by @entity130 were respectively analyzed. There were 833 males and 367 females,ranging from 20 to 78 (mean 41.94 +/- 15.41) years. All @entity1 had @entity4 and @entity158 in injured limbs when enrolled. @entity2996 was used to examine upper limbs vein at 3 to 10 d after improvement of @entity4 , 1 day before reduction. Relationship among occurrence of @entity715 , gender, age and @entity174 sites were analyzed. @entity1 with @entity11942 were analyzed with respective study to decide whether combined with @entity6 , @entity101 and @entity407 . RESULTS: All @entity1 were checked by @entity2996 ,which confirmed 9 cases with @entity11942 . The rate of @entity715 was 0.75%, @entity1 than @entity1 (P < 0.01). The risk of @entity4461 occurred over 30 years, and the occurrence of @entity715 in humerus @entity174 was higher than radius ulnar @entity174 . One of 9 @entity1 combined with @entity101 and @entity407 , 1 case combined with @entity6 , and 7 cases with no complication. CONCLUSION: Upper @entity174 may occur @entity1150 ; @entity2996 should be used to check @entity11942 in qualified hospital,which can maintain medical safety,decrease occurrence of medical disputes, and ganrantee @entity1 's safety.

title: [Significance of preoperative color doppler flow imaging for screening @entity1150 in XXXX ].

answer: @entity3140 :: (MESH:D038062,Disease) :: ['upper limbs fracture']


abstract: BACKGROUND: Modifications to @entity9834 ( @entity9834 ) are aimed at decreasing abdominal wall trauma and improving cosmetic outcome. Although @entity302 ( @entity302 ) provides excellent cosmetic results, the procedure is technically challenging and expensive compared to the conventional laparoscopic approach. OBJECTIVES: To describe a novel, hybrid technique combining @entity302 and conventional laparoscopy using minimal abdominal wall incisions. METHODS: Fifty @entity1 diagnosed with symptomatic @entity2963 were operated using two reusable 5 mm trocars inserted through a single 15 mm umbilical incision and a single 2-3 mm epigastric port. This technique was clubbed "minimal incision laparoscopic @entity9834 " (MILC). RESULTS: MILC was completed in 49 @entity1 (98%). In five @entity1 an additional 3 mm trocar was used and in 2 @entity1 the epigastric trocar was switched to a 5 mmtrocar. The procedure was converted to @entity9834 in one @entity1 . Mean operative time was 29 minutes (range 18-60) and the average postoperative hospital stay was 22 hours (range 6-50). There were no postoperative complications and the cosmetic results were rated excellent by the @entity1 . CONCLUSIONS: MILC is an intuitive, easy-to-learn and reproducible technique and requires small changes from @entity9834 . As such, MILC may be an attractive alternative, avoiding the cost and complexity drawbacks associated with @entity302 .

title: Advantages of minimal incision laparoscopic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2963 :: ('MESH:D002769', 'Disease') :: ['cholelithiasis']

entities_list: @entity9834 :: ('MESH:D017562', 'Disease') :: ['CLC', 'conventional laparoscopic cholecystectomy', 'cholecystectomy']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['single-incision laparoscopic surgery', 'SILS']

answer: @entity9834 :: (MESH:D017562,Disease) :: ['cholecystectomy']


abstract: BACKGROUND AND OBJECTIVE: Multidisciplinary management of @entity1555 ( @entity1555 ) has achieved outstanding results in developed nations. We aimed to describe the status of diagnosis and management of @entity1555 in a developing country through the experience of non-profit organizations. METHODS: A Multistate, multiple-source, population-based survey was performed from medical records of 432 @entity1 . Data were retrospectively collected, reviewed and curated by health specialists; including clinical features, age at first symptoms, age at diagnosis, disease progression and management, family history, education, age and cause of @entity204 . RESULTS: There is a delay in noticing first symptoms and it did not diminish over the past 20 years. Less than 30% of @entity1 obtained definite diagnosis and most of them are in physiotherapy programs but not under @entity134 treatment. In our study, family history does not anticipate recognition of symptoms compared to sporadic cases (p = 0.05). Approximately 93.33% of our @entity1 attended to education programs. Mean age at @entity204 was 18.94 +/- 6.73 years and the most frequent cause was @entity55 . CONCLUSION: Delayed diagnosis of @entity1555 in Mexico is mainly caused by the late detection of first symptoms. There is no difference in early detection of symptoms between familiar and sporadic cases. Lifespan of @entity1 in our cohort is reduced compared to developed countries. The late diagnosis and low percentage of definite cases may affect @entity1 management and genetic counseling and could also preclude participation of @entity1 into novel clinical trials.

title: XXXX in a developing country: challenges in management and genetic counseling.

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ['Duchenne Muscular Dystrophy', 'DMD']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

answer: @entity1555 :: (MESH:D020388,Disease) :: ['Duchenne muscular dystrophy']


abstract: @entity5419 to peanuts and nuts is an actual problem of practical health care, associated with significant prevalence of this disease, severe clinical symptoms and difficulty of diet organization. Purpose of the study--to study the prevalence of @entity5419 to peanut and hazelnut in Russian @entity1 , the investigation of clinical characteristics of this disease, and the mechanisms of sensitization to allergen components. The cross-sectional study was performed in the framework of the EuroPrevall (No FP6-2006-TTC-TU-5 Proposal 045879). The first stage was performed in random samples of primary schoolchildren aged 7-10 years (n = 13 010) from the Tomsk Region, Russia using a standardized questionnaire. The case-control sample was recruited for the second stage (n = 1288). Thus who reported adverse reactions to food in the screening stage were considered as cases (n = 652), @entity1 without reported reactions were controls (n = 636). The case-control stage included the completion of a clinical questionnaire, skin-prick test (ALK-Abelly, Spain), serum specific IgE measurement and component-resolved diagnostic: IgE measurement of allergen components of peanut (Ara h1, Ara h26, Ara h34, Ara h8), hazelnut (Cor a1, Cor a8, Cor a11) and birch allergen @entity3991 v1 (ImmunoCAP, Phadia, Sweden). The prevalence of @entity5419 to peanut and hazelnut in @entity1 aged 7-10 years in the Tomsk region is 0.08 and 0.09%, respectively. The manifestation of the @entity5419 to nuts occurs in the preschool years, main reactions associated with @entity566 to nuts were @entity566 (75-80%), @entity344 (60-80%) and @entity1910 (20-50%). Sensitization to birch is significantly correlated with the level of specific IgE to hazelnut (r = 0.53, p < 0.05) and peanut (r = 0.56, p < 0.05). Sensitization to heat-labile proteins peanut Ara h8 (12.3%) and hazelnut Cor a1 (8.8%) (homologues of @entity3991 v1) dominates in the sample of @entity1 with food sensitization, that determines the cross-reactivity mechanism in the formation of food sensitization in the studied sample. The prevalence of @entity566 to peanut and hazelnut in Russia is much lower than in Europe and North America. Sensitization to these foods develops by the mechanism of cross-reactivity with birch pollen allergen. This type of sensitization determines mild clinical symptoms of @entity566 to hazelnut and peanut.

title: [The prevalence of XXXX to peanut and hazelnut in @entity1 in Tomsk Region].

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity5419 :: ('MESH:D005512', 'Disease') :: ['food allergy', 'Food allergy']

entities_list: @entity1910 :: ('MESH:D005076', 'Disease') :: ['itching skin rash']

entities_list: @entity566 :: ('MESH:D006967', 'Disease') :: ['allergy', 'allergies', 'oral allergy syndrome']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disorders']

answer: @entity5419 :: (MESH:D005512,Disease) :: ['food allergy']


abstract: @entity5419 to peanuts and nuts is an actual problem of practical health care, associated with significant prevalence of this disease, severe clinical symptoms and difficulty of diet organization. Purpose of the study--to study the prevalence of @entity5419 to peanut and hazelnut in Russian @entity1 , the investigation of clinical characteristics of this disease, and the mechanisms of sensitization to allergen components. The cross-sectional study was performed in the framework of the EuroPrevall (No FP6-2006-TTC-TU-5 Proposal 045879). The first stage was performed in random samples of primary schoolchildren aged 7-10 years (n = 13 010) from the Tomsk Region, Russia using a standardized questionnaire. The case-control sample was recruited for the second stage (n = 1288). Thus who reported adverse reactions to food in the screening stage were considered as cases (n = 652), @entity1 without reported reactions were controls (n = 636). The case-control stage included the completion of a clinical questionnaire, skin-prick test (ALK-Abelly, Spain), serum specific IgE measurement and component-resolved diagnostic: IgE measurement of allergen components of peanut (Ara h1, Ara h26, Ara h34, Ara h8), hazelnut (Cor a1, Cor a8, Cor a11) and birch allergen @entity3991 v1 (ImmunoCAP, Phadia, Sweden). The prevalence of @entity5419 to peanut and hazelnut in @entity1 aged 7-10 years in the Tomsk region is 0.08 and 0.09%, respectively. The manifestation of the @entity5419 to nuts occurs in the preschool years, main reactions associated with @entity566 to nuts were @entity566 (75-80%), @entity344 (60-80%) and @entity1910 (20-50%). Sensitization to birch is significantly correlated with the level of specific IgE to hazelnut (r = 0.53, p < 0.05) and peanut (r = 0.56, p < 0.05). Sensitization to heat-labile proteins peanut Ara h8 (12.3%) and hazelnut Cor a1 (8.8%) (homologues of @entity3991 v1) dominates in the sample of @entity1 with food sensitization, that determines the cross-reactivity mechanism in the formation of food sensitization in the studied sample. The prevalence of @entity566 to peanut and hazelnut in Russia is much lower than in Europe and North America. Sensitization to these foods develops by the mechanism of cross-reactivity with birch pollen allergen. This type of sensitization determines mild clinical symptoms of @entity566 to hazelnut and peanut.

title: [The prevalence of @entity5419 to peanut and hazelnut in XXXX in Tomsk Region].

answer: @entity1 :: (9606,Species) :: ['children']


abstract: Offspring of long-lived parents have a low prevalence of @entity65 in middle age. The purposes of this study were to investigate @entity460 scores in offspring as compared to controls and to determine the influence of cardiovascular risk factors. CT coronary artery @entity460 score was measured in offspring of long-lived families (n = 244, 125 males) and their partners (n = 223, 96 males) who served as controls. @entity460 scores were analyzed separately for sexes. Subjects were grouped by very low @entity460 score  <=10 and scores above 10. Nonparametric Mann-Whitney test, chi-squared tests, and logistic regression analyses were performed to determine the association between @entity460 scores, familial longevity, and cardiovascular risk factors. More offspring of long-lived parents had lower @entity460 scores than controls. In @entity1 , 34 % of offspring had score  <=10 versus 21 % of controls (odds ratio (OR) and 95 % confidence interval (CI) 2.0, 1.08-3.7, p = 0.028). In @entity1 , 70 % of offspring had score  <=10 versus 54 % of controls ( @entity16133 , 95 % CI 1.13-3.4, p = 0.019). Differences remained significant after correction for age ( @entity1 , p = 0.043 and @entity1 , p = 0.003) and further correction for major risk factors in @entity1 , indicating genetic influence for lower @entity460 scores. In @entity1 , the association was found to be influenced by cardiovascular risk factors. @entity1 and @entity1 with a familial propensity to become long-lived have lower coronary artery @entity460 scores than controls. Low scores may indicate a younger biologic arterial age associated with a low risk for incident @entity65 .

title: Low computed tomography coronary artery XXXX scores in familial longevity: the Leiden Longevity Study.

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['calcium']


abstract: AIM: Bronchial artery angiography with @entity887 has become a mainstay in the treatment of massive hemoptysis. Whereas the immediate success rate is high, the reported long-term success rate varies widely among different groups. We aimed to explore the long-term outcome and clinical predictors associated with recurrent @entity548 . METHODS: We reviewed the clinical characteristics, underlying etiologies, procedure details, and outcome of @entity1416 performed for massive hemoptysis between 1999 and 2012. RESULTS: All 52 consecutive @entity1 treated by @entity1416 during the study period were included. The major etiologies of massive hemoptysis were @entity4595 (mostly post-infectious) in 53.8%, and primary and metastatic @entity2 in 30.8%. The immediate success rate was high (48/52; 92%). Of 45 @entity1 who survived more than 24 hours following @entity1416 , recurrent @entity548 did not occur in 19 (42.2%) during a median follow-up period of 60 months (range 6-130 months). Bleeding recurred in 26 (57.7%); within 30 days in 15 (33.3%) and after 1 month in the other 11 (24.4%). The average time to onset of early and late repeat @entity548 was 2 and 506 days, respectively. @entity2 were associated with a high likelihood of late @entity548 recurrence. CONCLUSIONS: Bronchial artery @entity887 is an effective immediate treatment for massive hemoptysis. Because the @entity548 recurrence rate is high in @entity1 with @entity2 or @entity4595 , surgery should be considered in these @entity1 following initial stabilization by @entity1416 . For other underlying etiologies, the long-term outcome is excellent.

title: Bronchial artery XXXX for massive hemoptysis: Long-term follow-up.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'bleeding following bronchial artery embolization']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['Idiopathic bronchiectasis and lung cancer', 'lung cancer']

entities_list: @entity1416 :: ('MESH:D020762', 'Disease') :: ['bronchial artery embolization']

entities_list: @entity887 :: ('MESH:D004617', 'Disease') :: ['embolization']

entities_list: @entity4595 :: ('MESH:D001987', 'Disease') :: ['idiopathic bronchiectasis', 'bronchiectasis']

answer: @entity887 :: (MESH:D004617,Disease) :: ['embolization']


abstract: IMPORTANCE: More than 300,000 @entity173 occur each year in the United States. Recent practice guidelines have advocated greater use of regional anesthesia for @entity173 surgery. OBJECTIVE: To test the association of regional (ie, @entity4282 ) anesthesia vs general anesthesia with 30-day mortality and hospital length of stay after @entity173 . DESIGN, SETTING, AND @entity1 : We conducted a matched retrospective cohort study involving @entity1 50 years or older who were undergoing surgery for @entity173 at general acute care hospitals in New York State between July 1, 2004, and December 31, 2011. Our main analysis was a near-far instrumental variable match that paired @entity1 who lived at different distances from hospitals that specialized in regional or general anesthesia. Supplementary analyses included a within-hospital match that paired @entity1 within the same hospital and an across-hospital match that paired @entity1 at different hospitals. EXPOSURES: Spinal or epidural anesthesia; general anesthesia. MAIN OUTCOMES AND MEASURES: Thirty-day mortality and hospital length of stay. Because the distribution of length of stay had long tails, we characterized this outcome using the Huber M estimate with Huber weights, a robust estimator similar to a trimmed mean. RESULTS: Of 56,729 @entity1 , 15,904 (28%) received regional anesthesia and 40,825 (72%) received general anesthesia. Overall, 3032 @entity1 (5.3%) died. The M estimate of the length of stay was 6.2 days (95% CI, 6.2 to 6.2). The near-far matched analysis showed no significant difference in 30-day mortality by anesthesia type among the 21,514 @entity1 included in this match: 583 of 10,757 matched @entity1 (5.4%) who lived near a regional anesthesia-specialized hospital died vs 629 of 10,757 matched @entity1 (5.8%) who lived near a general anesthesia-specialized hospital (instrumental variable estimate of risk difference, -1.1%; 95% CI, -2.8 to 0.5; P   =   .20). Supplementary analyses of within and across hospital @entity1 matches yielded mortality findings to be similar to the main analysis. In the near-far match, regional anesthesia was associated with a 0.6-day shorter length of stay than general anesthesia (95% CI, -0.8 to -0.4, P   <   .001). Supplementary analyses also showed regional anesthesia to be associated with shorter length of stay, although the observed association was smaller in magnitude than in the main analysis. CONCLUSIONS AND RELEVANCE: Among adults in acute care hospitals in New York State undergoing hip repair, the use of regional anesthesia compared with general anesthesia was not associated with lower 30-day mortality but was associated with a modestly shorter length of stay. These findings do not support a mortality benefit for regional anesthesia in this setting.

title: Anesthesia technique, mortality, and length of stay after XXXX surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity173 :: ('MESH:D006620', 'Disease') :: ['hip fractures', 'hip fracture']

entities_list: @entity4282 :: ('MESH:D046748', 'Disease') :: ['spinal or epidural']

answer: @entity173 :: (MESH:D006620,Disease) :: ['hip fracture']


abstract: INTRODUCTION: @entity31365 is now recognised as a leading cause of @entity311 in Malaysia. As @entity1 come into increasing contact with the reservoir host ( @entity5434 ) as a consequence of deforestation, assessing the potential for a shift from zoonotic to sustained @entity31365 transmission between @entity1 is critical. METHODS: A multi-host, multi-site transmission model was developed, taking into account the three areas (forest, farm, and village) where transmission is thought to occur. Latin hypercube sampling of model parameters was used to identify parameter sets consistent with possible prevalence in macaques and @entity1 inferred from observed data. We then explore the consequences of increasing @entity1 -macaque contact in the farm, the likely impact of rapid treatment, and the use of long-lasting insecticide-treated nets (LLINs) in preventing wider spread of this @entity281 . RESULTS: Identified model parameters were consistent with transmission being sustained by the macaques with spill over infections into the @entity1 population and with high overall basic reproduction numbers (up to 2267). The extent to which macaques forage in the farms had a non-linear relationship with @entity1 @entity281 prevalence, the highest prevalence occurring when macaques forage in the farms but return frequently to the forest where they experience higher contact with vectors and hence sustain transmission. Only one of 1,046 parameter sets was consistent with sustained @entity1 -to- @entity1 transmission in the absence of macaques, although with a low @entity1 reproduction number (R(0H) = 1.04). Simulations showed LLINs and rapid treatment provide personal protection to @entity1 with maximal estimated reductions in @entity1 prevalence of 42% and 95%, respectively. CONCLUSION: This model simulates conditions where @entity31365 transmission may occur and the potential impact of control measures. Predictions suggest that conventional control measures are sufficient at reducing the risk of @entity281 in @entity1 , but they must be actively implemented if @entity31365 is to be controlled.

title: Transmission and control of XXXX : a mathematical modelling study.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity5434 :: ('9541', 'Species') :: ['long-tailed macaques']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'emerging infection']

entities_list: @entity31365 :: ('5850', 'Species') :: ['Plasmodium knowlesi', 'P. knowlesi']

answer: @entity31365 :: (5850,Species) :: ['Plasmodium knowlesi']


abstract: Increasing survival rates in @entity5 have yielded a growing population of parents of @entity5 survivors (CCSs). This systematic review compiles the literature on positive and negative long-term @entity458 for parents of CCSs, reported at least five years after the @entity1 's diagnosis and/or two years after the end of the @entity1 's treatment. Systematic searches were made in the databases CINAHL, EMBASE, PsycINFO, and PubMed. Fifteen studies, published between 1988 and 2010, from 12 projects were included. Thirteen studies used quantitative methodology, one quantitative and qualitative methodology, and one qualitative methodology. A total of 1045 parents participated in the reviewed studies. Mean scores were within normal ranges for general @entity458 , coping, and family functioning. However, a substantial subgroup reported a clinical level of general @entity458 , and 21-44% reported a severe level of posttraumatic stress symptoms. Worry, disease-related thoughts and feelings, marital strains, as well as posttraumatic growth was reported. Several factors were associated with the long-term late effects, such as parents' maladaptive coping during earlier stages of the childs disease trajectory and @entity1 's current poor adjustment. Quality assessments of reviewed studies and clinical implications of findings are discussed and recommendations for future research are presented.

title: Long-term positive and negative XXXX for parents of @entity5 survivors: a systematic review.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['childhood cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'child']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress', 'psychological late effects']

answer: @entity458 :: (MESH:D020018,Disease) :: ['psychological late effects']


abstract: Increasing survival rates in @entity5 have yielded a growing population of parents of @entity5 survivors (CCSs). This systematic review compiles the literature on positive and negative long-term @entity458 for parents of CCSs, reported at least five years after the @entity1 's diagnosis and/or two years after the end of the @entity1 's treatment. Systematic searches were made in the databases CINAHL, EMBASE, PsycINFO, and PubMed. Fifteen studies, published between 1988 and 2010, from 12 projects were included. Thirteen studies used quantitative methodology, one quantitative and qualitative methodology, and one qualitative methodology. A total of 1045 parents participated in the reviewed studies. Mean scores were within normal ranges for general @entity458 , coping, and family functioning. However, a substantial subgroup reported a clinical level of general @entity458 , and 21-44% reported a severe level of posttraumatic stress symptoms. Worry, disease-related thoughts and feelings, marital strains, as well as posttraumatic growth was reported. Several factors were associated with the long-term late effects, such as parents' maladaptive coping during earlier stages of the childs disease trajectory and @entity1 's current poor adjustment. Quality assessments of reviewed studies and clinical implications of findings are discussed and recommendations for future research are presented.

title: Long-term positive and negative @entity458 for parents of XXXX survivors: a systematic review.

answer: @entity5 :: (MESH:D009369,Disease) :: ['childhood cancer']


abstract: Serological diagnosis of @entity4281 ( @entity4281 ) is a key element for efficient @entity1 treatment management. A rapid @entity1062 ( @entity1062 ) using the recombinant Em18 antigen (rEm18) was recently developed. The aim of our study was to assess this test on a panel of sera from French @entity1 with @entity4281 and control @entity1 . In a blind test, a total of 112 serum samples were tested including samples of @entity4281 (n  =  30), @entity8434 [ @entity8434 ] (n  =  15), and @entity8434 [ @entity8434 ] (n  =  1). For the comparison, 66 sera from @entity1 with hepatocarcinoma, @entity7736 , @entity13871 , @entity13550 , or @entity3619 were used. The diagnostic test sets we used were the rEm18- @entity1062 and two validated ELISAs with rEm18 and Em2-Em18 antigens, respectively. For the @entity1062 , 27/30 sera from @entity4281 @entity1 , 4/15 sera from @entity8434 @entity1 and the @entity8434 patient serum were positive. One serum from the control panel ( @entity13871 ) was positive for the @entity1062 . The rEm18- @entity1062 sensitivity (90.0%) and specificity (92.7%) for detection of Em18-specific antibodies confirmed it as a relevant tool for @entity4281 diagnosis. The rEm18-ELISA had a sensitivity of 86.7% and specificity of 91.5%, and the Em2-Em18-ELISA had a sensitivity of 96.7% and specificity of 87.8%. However, when @entity4281 @entity1 sera are recorded as weak in intensity with the @entity1062 , we recommend a double reading and use of a reference sample if the @entity1062 is used for @entity1 follow-up.

title: Comparison of the serological tests @entity1062 and ELISA for the diagnosis of XXXX in France   .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity8434 :: ('MESH:D004443', 'Disease') :: ['polycystic echinococcosis', 'CE', 'cystic echinococcosis', 'PE']

entities_list: @entity1062 :: ('MESH:D013736', 'Disease') :: ['immunochromatography test kit', 'ICT']

entities_list: @entity3619 :: ('MESH:D006521', 'Disease') :: ['autoimmune chronic active hepatitis']

entities_list: @entity13550 :: ('MESH:D016767', 'Disease') :: ["Caroli's disease"]

entities_list: @entity13871 :: ('MESH:D014120', 'Disease') :: ['toxocariasis']

entities_list: @entity7736 :: ('MESH:D005211', 'Disease') :: ['fascioliasis']

entities_list: @entity4281 :: ('MESH:C536591', 'Disease') :: ['AE', 'alveolar echinococcosis']

answer: @entity4281 :: (MESH:C536591,Disease) :: ['alveolar echinococcosis']


abstract: Serological diagnosis of @entity4281 ( @entity4281 ) is a key element for efficient @entity1 treatment management. A rapid @entity1062 ( @entity1062 ) using the recombinant Em18 antigen (rEm18) was recently developed. The aim of our study was to assess this test on a panel of sera from French @entity1 with @entity4281 and control @entity1 . In a blind test, a total of 112 serum samples were tested including samples of @entity4281 (n  =  30), @entity8434 [ @entity8434 ] (n  =  15), and @entity8434 [ @entity8434 ] (n  =  1). For the comparison, 66 sera from @entity1 with hepatocarcinoma, @entity7736 , @entity13871 , @entity13550 , or @entity3619 were used. The diagnostic test sets we used were the rEm18- @entity1062 and two validated ELISAs with rEm18 and Em2-Em18 antigens, respectively. For the @entity1062 , 27/30 sera from @entity4281 @entity1 , 4/15 sera from @entity8434 @entity1 and the @entity8434 patient serum were positive. One serum from the control panel ( @entity13871 ) was positive for the @entity1062 . The rEm18- @entity1062 sensitivity (90.0%) and specificity (92.7%) for detection of Em18-specific antibodies confirmed it as a relevant tool for @entity4281 diagnosis. The rEm18-ELISA had a sensitivity of 86.7% and specificity of 91.5%, and the Em2-Em18-ELISA had a sensitivity of 96.7% and specificity of 87.8%. However, when @entity4281 @entity1 sera are recorded as weak in intensity with the @entity1062 , we recommend a double reading and use of a reference sample if the @entity1062 is used for @entity1 follow-up.

title: Comparison of the serological tests XXXX and ELISA for the diagnosis of @entity4281 in France   .

answer: @entity1062 :: (MESH:D013736,Disease) :: ['ICT']