abstract: Normal blood flow patterns were characterized in individual CD @entity35 , nonpregnant (NP) or on day 6, 7, 8, 10, 11, 12, 13, 16, 18, or 20 of gestation using the radioactive microsphere technique. Five animals were evaluated at each stage of pregnancy. Weights and flow values were determined for several maternal organs and uterine tissue samples. Embryo/fetal (E/F) sex was determined from day 11 on by measuring the prevalence of nuclei with sex chromatin in amnion smears. There was a marked increase in absolute flow to the uterus and all uterine contents during gestation (0.28 +/- 0.13 ml/min to the NP, diestrous uterus; 9.07 +/- 0.97 ml/min on day 20 of pregnancy). However, relative blood flow (ml/min/g tissue) decreased by day 20 to one-third NP values. Thus, though blood flow greatly increased, it did so at a rate lower than total tissue growth (including the uterus, placental tissues, and the E/F itself). There was a rapid redistribution of blood flow from the decidua parietalis (DEC) to the @entity5028 ( @entity5028 ) on days 11-13, with nearly equal flow being delivered to the @entity5028 and DEC of the "average" embryo on day 12 of gestation. By day 16 the DEC functionally had atrophied, and nearly 100% of the flow was delivered to the @entity5028 . Male E/Fs tended to weigh more than female; however, these differences were statistically significant only on days 13, 18, and 20. E/F sex was not found to be strongly related to any of the variables evaluated in this study except E/F weight. Significant interlitter variability in E/F weight and blood flow consistently was observed at all gestational stages. Differences in litter size and E/F distribution within the two uterine horns did not account for the majority of this variability.

title: Blood flow during pregnancy in the XXXX : II. Dynamics of and litter variability in uterine flow.

entities_list: @entity5028 :: ('MESH:D010922', 'Disease') :: ['chorioallantoic placenta', 'CAP']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVE: @entity4053 is common in @entity6 ( @entity6 ). We aimed to update the incidence of severe and symptomatic @entity4053 and investigate several correlated factors. METHODS: In this multicenter, observational retrospective study, the data of 206 @entity6 @entity1 from a sample of 2,229 consecutive @entity1 seen at 18 @entity6 clinics were analyzed. Sociodemographic and clinical characteristics, severe @entity4053 in the past 12  months, and symptomatic @entity4053 in the past 4  weeks were recorded with a self-report questionnaire and a clinical form during a routine visit. Poisson multivariate models were applied. RESULTS: A minority of @entity1 accounted for the majority of both severe and symptomatic episodes. The incidence rate (IR) of severe @entity4053 was 0.49 (0.40-0.60) events/ @entity1 -years. The incidence rate ratio (IRR) was higher in @entity1 with previous severe @entity4053 (3.71; 2.28-6.04), @entity16 (4.16; 2.14-8.05), long duration (>20  years, 2.96; 1.60-5.45), and on polypharmacy (1.24; 1.13-1.36), but it was lower when a complication was present. The IR of symptomatic @entity4053 was 53.3 events/ @entity1 -years, with an IRR significantly higher among @entity1 or @entity1 with better education, or shorter duration or on pumps. The IRR was lower in @entity1 with higher BMI or @entity16 or aged more than 50  years. CONCLUSIONS: Fewer than 20  % of @entity6 @entity1 are free from @entity4053 , with one in six having experienced at least one severe episode in the last year. The distribution is uneven, with a tendency of episodes to cluster in some @entity1 . Severe and symptomatic episodes have different correlates and reflect different conditions.

title: Incidence and risk factors for severe and symptomatic @entity4053 in type 1 XXXX . Results of the HYPOS-1 study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'person']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['type 1 diabetes mellitus', 'T1DM', 'diabetes']

entities_list: @entity4053 :: ('MESH:D007003', 'Disease') :: ['Hypoglycemia', 'hypoglycemia']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: OBJECTIVE: @entity4053 is common in @entity6 ( @entity6 ). We aimed to update the incidence of severe and symptomatic @entity4053 and investigate several correlated factors. METHODS: In this multicenter, observational retrospective study, the data of 206 @entity6 @entity1 from a sample of 2,229 consecutive @entity1 seen at 18 @entity6 clinics were analyzed. Sociodemographic and clinical characteristics, severe @entity4053 in the past 12  months, and symptomatic @entity4053 in the past 4  weeks were recorded with a self-report questionnaire and a clinical form during a routine visit. Poisson multivariate models were applied. RESULTS: A minority of @entity1 accounted for the majority of both severe and symptomatic episodes. The incidence rate (IR) of severe @entity4053 was 0.49 (0.40-0.60) events/ @entity1 -years. The incidence rate ratio (IRR) was higher in @entity1 with previous severe @entity4053 (3.71; 2.28-6.04), @entity16 (4.16; 2.14-8.05), long duration (>20  years, 2.96; 1.60-5.45), and on polypharmacy (1.24; 1.13-1.36), but it was lower when a complication was present. The IR of symptomatic @entity4053 was 53.3 events/ @entity1 -years, with an IRR significantly higher among @entity1 or @entity1 with better education, or shorter duration or on pumps. The IRR was lower in @entity1 with higher BMI or @entity16 or aged more than 50  years. CONCLUSIONS: Fewer than 20  % of @entity6 @entity1 are free from @entity4053 , with one in six having experienced at least one severe episode in the last year. The distribution is uneven, with a tendency of episodes to cluster in some @entity1 . Severe and symptomatic episodes have different correlates and reflect different conditions.

title: Incidence and risk factors for severe and symptomatic XXXX in type 1 @entity6 . Results of the HYPOS-1 study.

answer: @entity4053 :: (MESH:D007003,Disease) :: ['hypoglycemia']


abstract: UNASSIGNED: Brucea javanica oil emulsion (BJOE), the petroleum ether extract of B. javanica emulsified by phospholipid, is widely used in China as an anticancer agent. The extracts from B. javanica induce @entity5 cell @entity204 by various mechanisms; however, it is not known whether these mechanisms involve autophagy, which is an important process in @entity5 development and treatment. Thus, the current study aimed to investigate whether BJOE modulates autophagy in HCT116 @entity1 @entity694 cells and whether modulation of autophagy is an anticancer mechanism of BJOE. Immunoblotting was employed to analyze the protein expression levels of microtubule-associated protein light-chain 3 ( @entity21684 ), a specific protein marker of autophagy, in HCT116 @entity5 cells following exposure to BJOE. The apoptosis rate of the HCT116 @entity5 cells was detected by performing an @entity4404 - @entity2822 / @entity2667 assay. According to the effect of BJOE administration on autophagy in the HCT116 @entity5 cells (induction or suppression), a functionally opposite agent (autophagy suppressor or inducer) was applied to counteract this effect, and the apoptosis rate of the @entity5 cells was detected again. The role of autophagy (pro-survival or pro- @entity204 ) was demonstrated by comparing the rates of apoptotic @entity5 cells prior to and following the counteraction. The results revealed that BJOE suppressed the protein expression levels of @entity21684 , including the @entity21684 -I and @entity21684 -II forms, and induced apoptosis in the HCT116 @entity5 cells with a high level of basal @entity21684 . The apoptosis-inducing activity of BJOE was significantly attenuated when autophagy was induced by the administration of @entity7970 , an autophagy inducer. The data indicates that autophagy inhibition is involved in BJOE-induced @entity5 cell @entity204 , and that this inhibition may be a potential anticancer mechanism of BJOE.

title: Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced XXXX cell @entity204 .

entities_list: @entity7970 :: ('MESH:D014199', 'Chemical') :: ['trehalose']

entities_list: @entity2667 :: ('MESH:D011419', 'Chemical') :: ['propidium iodide']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity2822 :: ('CHEBI:37926', 'Chemical') :: ['fluorescein isothiocyanate']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon cancer']


abstract: UNASSIGNED: Brucea javanica oil emulsion (BJOE), the petroleum ether extract of B. javanica emulsified by phospholipid, is widely used in China as an anticancer agent. The extracts from B. javanica induce @entity5 cell @entity204 by various mechanisms; however, it is not known whether these mechanisms involve autophagy, which is an important process in @entity5 development and treatment. Thus, the current study aimed to investigate whether BJOE modulates autophagy in HCT116 @entity1 @entity694 cells and whether modulation of autophagy is an anticancer mechanism of BJOE. Immunoblotting was employed to analyze the protein expression levels of microtubule-associated protein light-chain 3 ( @entity21684 ), a specific protein marker of autophagy, in HCT116 @entity5 cells following exposure to BJOE. The apoptosis rate of the HCT116 @entity5 cells was detected by performing an @entity4404 - @entity2822 / @entity2667 assay. According to the effect of BJOE administration on autophagy in the HCT116 @entity5 cells (induction or suppression), a functionally opposite agent (autophagy suppressor or inducer) was applied to counteract this effect, and the apoptosis rate of the @entity5 cells was detected again. The role of autophagy (pro-survival or pro- @entity204 ) was demonstrated by comparing the rates of apoptotic @entity5 cells prior to and following the counteraction. The results revealed that BJOE suppressed the protein expression levels of @entity21684 , including the @entity21684 -I and @entity21684 -II forms, and induced apoptosis in the HCT116 @entity5 cells with a high level of basal @entity21684 . The apoptosis-inducing activity of BJOE was significantly attenuated when autophagy was induced by the administration of @entity7970 , an autophagy inducer. The data indicates that autophagy inhibition is involved in BJOE-induced @entity5 cell @entity204 , and that this inhibition may be a potential anticancer mechanism of BJOE.

title: Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced @entity694 cell XXXX .

answer: @entity204 :: (MESH:D003643,Disease) :: ['death']


abstract: PURPOSE: To assess the prognostic value of the number of negative lymph nodes (NLNs) in @entity0 @entity1 with positive axillary lymph nodes after mastectomy and its predictive value for radiotherapy efficacy of different @entity0 subtypes (BCS). METHODS: The records of 1,260 @entity0 @entity1 with positive axillary lymph nodes who received mastectomy between January 1998 and December 2007 were reviewed. The prognostic impact and predictive value of the number of NLNs with respect to locoregional recurrence-free survival (LRFS), disease-free survival (DFS), and @entity1349 ( @entity1349 ) were analyzed. RESULTS: The median follow-up time was 58 months, and 444 @entity1 (35.2%) received postmastectomy radiotherapy (PMRT). Univariate and multivariate Cox survival analysis indicated the number of NLNs was an independent prognostic factor of LRFS, DFS, and @entity1349 . @entity1 with a higher number of NLNs had better survival. PMRT improved the LRFS of @entity1 with  <= 8 NLNs ( p < 0.001), while failing to improve the LRFS of @entity1 with > 8 NLNs (p = 0.075). In @entity1 with luminal A subtype, PMRT improved the LRFS, DFS, and @entity1349 of @entity1 with  <= 8 NLNs, but in @entity1 with > 8 NLNs only the LRFS was improved. For @entity1 with luminal B subtype, PMRT only improved the LRFS of @entity1 with  <= 8 NLNs. The number of NLNs had no predictive value for the efficacy with PMRT in Her2+ and triple-negative subtypes. CONCLUSIONS: The number of NLNs is a prognostic indicator in @entity1 with @entity0 , and it can predict the efficacy of PMRT according to different BCS.

title: Number of negative lymph nodes can predict survival after postmastectomy radiotherapy according to different XXXX subtypes.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'node-positive breast cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']


abstract: PURPOSE: To assess the clinical value of FDG PET/CT and evaluate the complementary roles of serum squamous cell carcinoma antigen (SCCAg) and FDG PET/CT in the diagnosis of suspected recurrent of cervical @entity1544 . METHODS: Serum SCCAg levels were retrospectively reviewed in @entity1 previously treated for @entity957 , who had suspected recurrence of cervical @entity5 and who had undergone FDG PET/CT scans. The clinical impact of elevated SCCAg (>1.5 ng/ml) and negative SCCAg ( <=1.5 ng/ml) levels were analyzed based on the results of PET/CT and final diagnosis. RESULTS: The overall @entity1 -based sensitivity, specificity, accuracy, positive predictive value ( @entity2286 ) and negative predictive value (NPV) of PET/CT for the detection of @entity5 recurrence or @entity5 were 100% (86/86), 80.8% (21/26), 95.5% (107/112), 94.5% (86/91) and 100% (21/21), respectively. Of the 112 @entity1 included in this study, recurrence or @entity5 was detected by PET/CT in 62 of the 64 @entity1 with elevated SCCAg, compared to 24 of the 48 @entity1 with negative SCCAg levels. The overall @entity1 -based @entity2286 , NPV, sensitivity and accuracy of SCCAg for the detection of @entity5 recurrence or @entity5 were 96.9% (62/64), 50% (24/48), 72.1% (62/86) and 76.8% (86/112), respectively. The five false-positive PET/CT results were all associated with @entity1 with negative SCCAg levels. The @entity2286 of positive PET/CT-associated elevated SCCAg for the detection of @entity5 recurrence or @entity5 was 100% (62/62). The NPV of negative SCCAg-associated negative PET/CT was 100% (19/19). CONCLUSIONS: Serum SCCAg evaluation and FDG PET/CT imaging can be complementary techniques in cases of suspected recurrent cervical @entity5 . Positive PET/CT with elevated SCCAg can predict recurrence. Although PET/CT cannot confidently be deferred due to a negative SCCAg test, the possibility of a false-positive PET/CT in those cases may have diagnostic importance.

title: Complementary Roles of XXXX Antigen and (18)F-FDG PET/CT in Suspected Recurrence of @entity1544 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'malignancy', 'squamous cancer']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['cervical squamous cell carcinoma']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell cancer']

answer: @entity957 :: (MESH:D002294,Disease) :: ['Squamous Cell Carcinoma']


abstract: PURPOSE: To assess the clinical value of FDG PET/CT and evaluate the complementary roles of serum squamous cell carcinoma antigen (SCCAg) and FDG PET/CT in the diagnosis of suspected recurrent of cervical @entity1544 . METHODS: Serum SCCAg levels were retrospectively reviewed in @entity1 previously treated for @entity957 , who had suspected recurrence of cervical @entity5 and who had undergone FDG PET/CT scans. The clinical impact of elevated SCCAg (>1.5 ng/ml) and negative SCCAg ( <=1.5 ng/ml) levels were analyzed based on the results of PET/CT and final diagnosis. RESULTS: The overall @entity1 -based sensitivity, specificity, accuracy, positive predictive value ( @entity2286 ) and negative predictive value (NPV) of PET/CT for the detection of @entity5 recurrence or @entity5 were 100% (86/86), 80.8% (21/26), 95.5% (107/112), 94.5% (86/91) and 100% (21/21), respectively. Of the 112 @entity1 included in this study, recurrence or @entity5 was detected by PET/CT in 62 of the 64 @entity1 with elevated SCCAg, compared to 24 of the 48 @entity1 with negative SCCAg levels. The overall @entity1 -based @entity2286 , NPV, sensitivity and accuracy of SCCAg for the detection of @entity5 recurrence or @entity5 were 96.9% (62/64), 50% (24/48), 72.1% (62/86) and 76.8% (86/112), respectively. The five false-positive PET/CT results were all associated with @entity1 with negative SCCAg levels. The @entity2286 of positive PET/CT-associated elevated SCCAg for the detection of @entity5 recurrence or @entity5 was 100% (62/62). The NPV of negative SCCAg-associated negative PET/CT was 100% (19/19). CONCLUSIONS: Serum SCCAg evaluation and FDG PET/CT imaging can be complementary techniques in cases of suspected recurrent cervical @entity5 . Positive PET/CT with elevated SCCAg can predict recurrence. Although PET/CT cannot confidently be deferred due to a negative SCCAg test, the possibility of a false-positive PET/CT in those cases may have diagnostic importance.

title: Complementary Roles of @entity957 Antigen and (18)F-FDG PET/CT in Suspected Recurrence of XXXX .

answer: @entity1544 :: (MESH:D018307,Disease) :: ['Cervical Squamous Cell Cancer']


abstract: The irreversible loss of cardiomyocytes remains a key problem to resolve, which forms the cellular basis of @entity299 . MSCs transplantation brings out a promising potential for myocardial renovation with less limitations. However, this cell transplantation therapy is limited by its poor viability after transplantation. Apoptosis is thought to be the major factor that affects the efficiency of MSCs transplantation. Therefore, exploring the process of apoptosis and the underlying mechanisms of MSCs in the 'harmful' microenvironment is significant for the sake of improving the efficiency of MSCs transplantation therapy. A @entity519 /reoxygenation (H/R) model of MSCs had been established. TUNEL, Hoechst staining and MTT were used for the evaluation of morphological changes, cell viability and apoptosis. Mitochondrial transmembrane potential was detected by JC-1 using the fluorescence microscopy system. The protein expression of @entity4674 , @entity7952 , p-AKT, @entity588 , @entity589 , p-JNK, @entity7738 and @entity7 was assessed for the analysis of protein changes using the Western blot. In our study, H/R insult lead to apoptosis and cell viability lost in a time-dependent manner in MSCs. Multiple pathways were involved in the apoptosis of MSCs, including @entity4674 released from mitochondria to cytosol, mitochondrial transmembrane potential lost. In addition, @entity7952 and p-AKT were downregulated, while @entity588 , p-JNK and @entity7 were upregulated. H/R induced the apoptosis in MSCs is through multiple pathways. These multiple pathways will be helpful for understanding and explaining the process and mechanism of apoptosis in MSCs.

title: Apoptosis of bone marrow mesenchymal stem cells caused by XXXX /reoxygenation via multiple pathways.

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac dysfunction']

answer: @entity519 :: (MESH:D000860,Disease) :: ['hypoxia']


abstract: Essential oil has performed a variety of indirect services used as insect/pest repellent. The present study investigated the acute and subchronic @entity137 of eucalyptus oil @entity11896 ( @entity11896 ). In addition, we conduct safety pharmacology evaluation of @entity11896 to supplement the @entity137 tests and provide a basis for a comprehensive understanding of the @entity137 of @entity11896 . Acute administration of @entity11896 was done as single dose from 2772 mg to 5742 mg of @entity11896 per kg/bodyweight (b.wt.) and subchronic @entity137 study for thirty days was done by daily oral administration of @entity11896 at doses of 396, 792 and 1188 mg/kg b.wt. In SPF SD @entity35 . The acute @entity137 study showed the LD50 of @entity11896 was 3811.5 mg/kg. The subchronic @entity137 study suggested the high-dose and middle-dose @entity11896 slowed down the growth of male @entity35 . The clinical pathology showed the high-dose and middle-dose @entity11896 could cause @entity8 . The safety pharmacology indicated that @entity11896 had no side effects on @entity35 . These results suggest that @entity11896 is a safe veterinary medicine for external use.

title: XXXX as well as evaluation of safety pharmacology of eucalyptus oil-water emulsions.

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['damage to liver and kidney']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity11896 :: ('MESH:D014869', 'Disease') :: ['emulsion in water', 'EOE']

answer: @entity137 :: (MESH:D064420,Disease) :: ['Acute and subchronic toxicity']


abstract: AIM: To investigate the characteristic of mature dendritic cell ( @entity13128 ) and tolerogenic dendritic cell (TDC) in @entity1 lower limb @entity432 ( @entity432 ) and @entity6 foot and in vitro. METHODS: 58 @entity1 @entity432 and @entity6 foot arterial specimens were collected from surgical operation and autopsy. Immunohistochemical and Western blotting method were used to examine the distribution and the content of @entity8730 and @entity4896 positive reaction @entity13128 and @entity9536 and @entity13128 -SIGN positive reaction TDC. Furthermore, bone marrow-derived DCs were induced by rmGM-CSF and rmIL-4 in the presence or absence of @entity558 in vitro. The percent of @entity2935 (+) @entity9536 (+)TDC and @entity2935 (+) @entity8730 (+) @entity13128 were analyzed by flow cytometry. The effects of TDC and @entity13128 on T lymphocytes were analyzed by the @entity4155 level, the percent of Th17, and @entity4155 mRNA expression. RESULTS: Immunogenicity @entity13128 was heavily found in intima plaque and around the small vessel of adventitia on artherosclerosis aorta of lesion group, and was positively correlated to the progress of the disease. However, there were low expression of TDC and was negatively correlated to the progress of the disease. Meanwhile, we found that there is a close relationship between high glucose and disease progression. TDC expressed high levels of @entity688 and @entity2533 and down-regulated the percent of @entity404 (+) @entity4155 (+) Th17, @entity4155 mRNA and the level of @entity4155 in vitro. CONCLUSION: TDC and @entity13128 are assembled in the process of @entity432 , and the progression of the disease might be aggravated by @entity13128 -maturation. High glucose might closely relate to the progression of @entity731 .

title: Characteristics of immunogenic and tolerogenic dendritic cells within the arterial wall in XXXX and in vitro.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['ASO', 'atherosclerosis occlusion syndrome']

answer: @entity731 :: (MESH:D050197,Disease) :: ['atherosclerosis']


abstract: BACKGROUND: There is an increasing number of urgently ill and injured @entity1 being seen in @entity341 ( @entity341 ) of developing countries. The pediatric disease burden in EDs across Pakistan is generally unknown. Our main objective was to determine the spectrum of disease and injury among @entity1 seen in EDs in Pakistan through a nationwide @entity341 -based surveillance system. METHODS: Through the Pakistan National Emergency Department Surveillance (Pak-NEDS), data were collected from November 2010 to March 2011 in seven major tertiary care centers representing all provinces of Pakistan. These included five public and two private hospitals, with a collective annual census of over one million @entity341 encounters. RESULTS: Of 25,052 @entity1 registered in Pak-NEDS (10% of all @entity1 seen): 61% were male, 13% under 5 years, while almost 65% were between 10 to < 16 years. The majority (90%) were seen in public hospital EDs. About half the @entity1 were discharged from the EDs, 9% admitted to hospitals and only 1.3% died in the EDs. Injury (39%) was the most common presenting complaint, followed by @entity221 (19%) and @entity344 (18%). Injury was more likely in males vs. females (43% vs. 33%; p < 0.001), with a peak presentation in the 5-12 year age group (45%). CONCLUSIONS: Pediatric @entity1 constitute a smaller proportion among general @entity341 users in Pakistan. Injury is the most common presenting complaint for @entity1 seen in the @entity341 . These data will help in resource allocation for cost effective pediatric @entity341 service delivery systems. Prospective longer duration surveillance is needed in more representative pediatric EDs across Pakistan.

title: The pediatric disease spectrum in XXXX across Pakistan: data from a pilot surveillance system.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['ED', 'emergency departments']

entities_list: @entity221 :: ('MESH:D005334', 'Disease') :: ['fever/malaise']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal symptoms']

answer: @entity341 :: (MESH:D004630,Disease) :: ['emergency departments']


abstract: This study aims to evaluate clinical efficacy of short segment pedicle screw fixation without bone fusion for unstable thoracolumbar burst @entity174 . Nineteen @entity1 younger than 40 years old with unstable thoracolumbar burst @entity174 were included. The surgical procedure included postural reduction for 3 days and screw fixations at one level above, one level below and at the fractured level itself. The implants were removed 12 months after initial operation. Imaging and clinical findings were analyzed at preoperative, 12 months after surgery, just before implant removal, and at six months after implant removal. Results indicated that difference was statistically significant between preoperative period or postoperative 1 year follow-up, just before implant removal and 6 months after implant removal (P < 0.05). Results at postoperative 1 year follow-up, just before implant removal and 6 months after implant removal were better than preoperative period. There were no significant complications or @entity16 after screws insert and removal in any @entity1 . The rate of clinical outcome with excellent and good was 94.7%. In conclusion, short segment pedicle screw fixation without bone fusion can be an effective and safe operative srategytechnique in the management of young @entity1 suffering from unstable burst @entity174 .

title: Short segment screw fixation without fusion in treatment for unstable thoracolumbar burst XXXX .

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological deterioration']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture']


abstract: We recently experienced two @entity1 with @entity64 -like symptoms and ascending @entity1580 (AAD) in our outpatient department. Both @entity1 were transferred to our hospital presenting with @entity51 such as @entity1269 and conjugate deviation. They did not complain from any chest or @entity490 . Their MRI did not show fresh @entity1188 or main @entity732 . A chest CT image showed AAD. The former @entity1 was immediately transferred to a tertiary hospital and the latter received conservative management in the cardiovascular department. Discussion. As neither @entity1 was experiencing any @entity158 , we initially diagnosed them with @entity385 and began treatment. Fortunately, @entity548 complications did not occur. In such cases, problems are caused when intravenous @entity3479 ) injection is administered with the aim of reopening the occluded intracranial arteries. In fact, @entity1 with AAD undergoing t-PA injection have been reported to die from @entity548 complications without any recognition of the dissection. These findings suggest that confirmation using carotid ultrasound, carotid MR angiography, and a D-dimer test is crucial and should be adopted in emergency departments.

title: Consideration of two cases of ascending @entity1580 that began with XXXX -like symptoms.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1269 :: ('MESH:D010291', 'Disease') :: ['hemiparesis']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity732 :: ('MESH:D015356', 'Disease') :: ['branch occlusion']

entities_list: @entity3479 :: ('5327', 'Gene') :: ['tissue plasminogen activator (t-PA']

entities_list: @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: We recently experienced two @entity1 with @entity64 -like symptoms and ascending @entity1580 (AAD) in our outpatient department. Both @entity1 were transferred to our hospital presenting with @entity51 such as @entity1269 and conjugate deviation. They did not complain from any chest or @entity490 . Their MRI did not show fresh @entity1188 or main @entity732 . A chest CT image showed AAD. The former @entity1 was immediately transferred to a tertiary hospital and the latter received conservative management in the cardiovascular department. Discussion. As neither @entity1 was experiencing any @entity158 , we initially diagnosed them with @entity385 and began treatment. Fortunately, @entity548 complications did not occur. In such cases, problems are caused when intravenous @entity3479 ) injection is administered with the aim of reopening the occluded intracranial arteries. In fact, @entity1 with AAD undergoing t-PA injection have been reported to die from @entity548 complications without any recognition of the dissection. These findings suggest that confirmation using carotid ultrasound, carotid MR angiography, and a D-dimer test is crucial and should be adopted in emergency departments.

title: Consideration of two cases of ascending XXXX that began with @entity64 -like symptoms.

answer: @entity1580 :: (MESH:C562834,Disease) :: ['aortic dissection']


abstract: OBJECTIVE: Compare the efficacy of surrogate or gestational carrier (GC) cycles to that of autologous @entity52 ( @entity52 )/intracytoplasmic sperm injections (ICSI) in @entity1 with gynecologic or medical co-morbidities contraindicative to pregnancy. DESIGN: Retrospective cohort study. SETTING: @entity249 @entity1 from a single university hospital-based program from 1998-2009. INTERVENTIONS: 128 GC cycles from 80 intended parents were identified and compared with 15,311 @entity52 or ICSI cycles. MAIN OUTCOME MEASURES: The peak @entity53 (E2), number of oocytes retrieved, cycle cancellation, ongoing pregnancy, and live-birth were compared between GCs and autologous @entity52 carriers. Indications for GC use were also identified. Multiple cycles contributed by the same @entity1 were accounted for using multivariable generalized estimating equations and two-sided Wald p-values. RESULTS: Uterine factors (67%) was the most common indication for using a GC, followed by non-gynecologic medical conditions including @entity1003 (13%), @entity454 (10%), @entity65 (5%) and @entity5 (5%). Adjusting for age, ovulation induction in GC cycles had similar peak E2 levels and number of oocytes retrieved relative to @entity52 cycles (p = 0.23 and 0.43, respectively). Clinical pregnancy (49% vs. 42%, p = 0.28) and live-birth rates (31% vs. 32%, p = 0.74) were also comparable. A sub-analysis of GC cycles in those @entity1 with uterine factor indications, demonstrated significantly higher clinical pregnancy rates (OR = 2.0; CI = 1.2 - 3.5) with 60% greater odds of live-birth relative to @entity52 /ICSI cycles, however this odds was not statistically significant for differences in live-birth (CI = 0.9 - 2.9). Conclusions: GCs are a viable alternative to start families for @entity1 with medical co-morbidities precluding pregnancy.

title: Gestational carriers: A viable alternative for XXXX with medical contraindications to pregnancy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['Infertility']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1003 :: ('MESH:D001778', 'Disease') :: ['coagulopathies']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilization']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end stage renal disease']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: A study is reported which tries to identify those members of the general population who may be at increased risk of @entity455 . It is probable that @entity1 who have had previous @entity715 episodes are inherently more at risk of further episodes and that a @entity715 many months ago will not affect current tests. Accordingly we carried out a number of tests involving platelets on 'controls', and on @entity1 with a past history of either @entity583 or @entity1150 ( @entity1150 ) and @entity1 suffering from @entity613 who also are assumed to be at higher risk than the controls. Differences were demonstrated between controls and @entity1 groups and these differences were utilized to develop statistical functions with the ability to discriminate between the groups. The functions were then tested using a second set of data from similar groups. Those designed to discriminate between @entity583 @entity1 and controls and between @entity1 with @entity613 and controls were validated. The heparin @entity556 clotting time was found to be the prime predictor variable; the platelet count, platelet volume, platelet factor 3 clotting time and the bleeding time have some predictive value. The @entity5582 clotting time, @entity1423 and platelet adhesiveness tests as measured were not found to have discriminating potential. It is suggested that these appropriate risk functions could be of practical value in identifying members of the general population who may be at greater risk than average. The discriminate functions for @entity1150 @entity1 and controls could not be validated, suggesting differences in platelet involvement in arterial and @entity49 .

title: Platelets in the prediction of XXXX risk.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['platelet aggregation']

entities_list: @entity49 :: ('MESH:D019851', 'Disease') :: ['venous thrombosis']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis', 'DVT']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['claudication', 'intermittent claudication']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'thrombotic']

answer: @entity715 :: (MESH:D013927,Disease) :: ['thrombotic']


abstract: PURPOSE: To study the demographic characteristics of @entity2194 in Central Sarawak and identify the determinant factors of poor visual outcome. DESIGN: A retrospective study of @entity2194 cases presenting at the referral hospital in 2013. METHODS: @entity1 were identified and recruited from hospital records. Those presenting for follow-up review were excluded. Case records were retrieved and reviewed after recruitment. RESULTS: We studied 168 @entity1 with 179 @entity4858 , of which 44% were work related. Compared with non-work-related cases, work-related cases were more likely to be male [odds ratio (OR), 19.7; 95% confidence interval (CI), 2.6-150.9] and foreign (OR, 18.0; 95% CI, 2.3-142.0). @entity542 constituted a higher percentage of @entity227 (VA) during the first visit: 84.6% compared with 18.1% for closed @entity130 (OR, 25.0; 95% CI, 5.3-118.4; P < 0.001). Of the @entity542 , 61.5% worsened or showed no improvement in VA after 3 months compared with closed @entity130 (28.9%) (OR, 3.9; 95% CI, 1.2-12.7; P = 0.015). Of cases presenting 7 or more days after @entity130 , 76.9% worsened or showed no improvement in VA after 3 months compared with those presenting in less than 7 days (27.7%) (OR, 8.7; 95% CI, 2.3-33.0; P < 0.001). Among those with work-related injuries, 23.1% had used eye protective devices (EPDs). CONCLUSIONS: @entity4858 in Central Sarawak were predominantly work related, occurring at industrial premises, and involving males and foreigners. Both @entity542 and a delay in seeking treatment resulted in significantly poorer visual outcomes.

title: Determinant Factors of Poor Visual Outcome After XXXX : A Retrospective Study in Central Sarawak, Malaysia.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['ocular trauma']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['impaired visual acuity']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['open globe injuries', 'Open globe injuries']

entities_list: @entity4858 :: ('MESH:D005131', 'Disease') :: ['Ocular injuries', 'ocular injuries']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['globe injuries', 'trauma']

answer: @entity2194 :: (MESH:D005128,Disease) :: ['Ocular Trauma']


abstract: UNASSIGNED: The sensitivity of @entity32454 mRNA-based Aptima HPV test (AHPV; Hologic Inc) for detection of cervical @entity5 has been reported based on only a small number of cases. We determined the sensitivity of AHPV in comparison with the DNA-based Hybrid Capture 2 HPV test ( @entity14043 ; Qiagen) for the detection of oncogenic HPV in a large number of @entity5 at the time of diagnosis using cervical samples obtained in ThinPrep (Hologic). Samples yielding discordant results were genotyped using Linear Array assay (LA; Roche). Of 396 cases tested, AHPV detected 377 (sensitivity, 95.2%; 95% CI: 93.1 - 97.3), and @entity14043 376 (sensitivity, 94.9%; 95% CI: 92.7 - 97.1) with an agreement of 97.2% (kappa 0.7; 95% CI: 0.54-0.87). Among six AHPV   +   / @entity14043 - cases, LA identified oncogenic HPV types in four including a type 73 and was negative in two. Among five AHPV-/ @entity14043 + cases, LA detected oncogenic HPV types in two including a type 73 and was negative in three. Of 14 AHPV-/ @entity14043 - cases, 13 were genotyped. LA detected oncogenic HPV types in six, non-oncogenic types in three, and was negative in four. This is the largest study to demonstrate the sensitivity of AHPV for the detection of @entity3 and this assay showed equal sensitivity to @entity14043 . This article is protected by copyright. All rights reserved.

title: Sensitivity of APTIMA HPV @entity32454 mRNA test in comparison with hybrid capture 2 HPV DNA test for detection of high risk oncogenic human papillomavirus in 396 biopsy confirmed XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cervical cancers']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cervical cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cervical cancers']


abstract: UNASSIGNED: The sensitivity of @entity32454 mRNA-based Aptima HPV test (AHPV; Hologic Inc) for detection of cervical @entity5 has been reported based on only a small number of cases. We determined the sensitivity of AHPV in comparison with the DNA-based Hybrid Capture 2 HPV test ( @entity14043 ; Qiagen) for the detection of oncogenic HPV in a large number of @entity5 at the time of diagnosis using cervical samples obtained in ThinPrep (Hologic). Samples yielding discordant results were genotyped using Linear Array assay (LA; Roche). Of 396 cases tested, AHPV detected 377 (sensitivity, 95.2%; 95% CI: 93.1 - 97.3), and @entity14043 376 (sensitivity, 94.9%; 95% CI: 92.7 - 97.1) with an agreement of 97.2% (kappa 0.7; 95% CI: 0.54-0.87). Among six AHPV   +   / @entity14043 - cases, LA identified oncogenic HPV types in four including a type 73 and was negative in two. Among five AHPV-/ @entity14043 + cases, LA detected oncogenic HPV types in two including a type 73 and was negative in three. Of 14 AHPV-/ @entity14043 - cases, 13 were genotyped. LA detected oncogenic HPV types in six, non-oncogenic types in three, and was negative in four. This is the largest study to demonstrate the sensitivity of AHPV for the detection of @entity3 and this assay showed equal sensitivity to @entity14043 . This article is protected by copyright. All rights reserved.

title: Sensitivity of APTIMA HPV XXXX mRNA test in comparison with hybrid capture 2 HPV DNA test for detection of high risk oncogenic human papillomavirus in 396 biopsy confirmed @entity5 .

answer: @entity32454 :: (25479186,Gene) :: ['E6/E7']


abstract: UNASSIGNED: Complement inhibitors have not been thoroughly evaluated in the treatment of acute antibody-mediated rejection (ABMR). We performed a prospective, single-arm pilot study to investigate the potential effects and safety of @entity19459 ( @entity38524 ) Berinert added to high-dose intravenous immunoglobulin (IVIG) for the treatment of acute ABMR that is nonresponsive to conventional therapy. Kidney recipients with nonresponsive active ABMR and acute allograft dysfunction were enrolled between April 2013 and July 2014 and received @entity38524 and IVIG for 6 months (six @entity1 ). The primary end point was the change in @entity470 at 6 months after inclusion (M+6). Secondary end points included the changes in histology and DSA characteristics and adverse events as evaluated at M+6. All @entity1 showed an improvement in @entity470 between inclusion and M+6: from 38.7    17.9 to 45.2    21.3 mL/min/1.73 m(2) (p = 0.0277). There was no change in histological features, except a decrease in the C4d deposition rate from 5/6 to 1/6 (p = 0.0455). There was a change in DSA C1q status from 6/6 to 1/6 positive (p = 0.0253). One @entity1150 was observed. In a secondary analysis, C1- @entity19459 @entity1 were compared with a similar historical control group (21 @entity1 ). @entity38524 added to IVIG is safe and may improve allograft function in kidney recipients with nonresponsive acute ABMR.

title: XXXX in Acute Antibody-Mediated Rejection Nonresponsive to Conventional Therapy in Kidney Transplant Recipients: A Pilot Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis']

answer: @entity19459 :: (710,Gene) :: ['C1 Inhibitor']


abstract: BACKGROUND: The anesthetic management of @entity1 undergoing endovascular treatment of @entity438 in the interventional neuroradiology suite can be challenged by @entity2332 because of low ambient temperature for operating and maintaining its equipments. We evaluated the efficacy of skin surface warming prior to induction of anesthesia to prevent the decrease in core temperature and reduce the incidence of @entity2332 . METHODS: Seventy-two @entity1 were randomized to pre-warmed and control group. The @entity1 in pre-warmed group were warmed 30  minutes before induction with a forced-air warming blanket set at 38  C. Pre-induction tympanic temperature (Tpre) was measured using an infrared tympanic thermometer and core temperature was measured at the esophagus immediately after intubation (T0) and recorded at 20  minutes intervals (T20, T40, T60, T80, T100, and T120). The number of @entity1 who became hypothermic at each time was recorded. RESULTS: Tpre in the control and pre-warmed group were 36.4        0.4  C and 36.6        0.3  C, whereas T0 were 36.5        0.4  C and 36.6        0.2  C. Core temperatures in the pre-warmed group were significantly higher than the control group at T20, T40, T60, T80, T100, and T120 (P   <   0.001). Compared to T0, core temperatures at each time were significantly lower in both two groups (P   =   0.007 at T20 in pre-warmed group, P   <   0.001 at the other times in both groups). The incidence of @entity2332 was significantly lower in the pre-warmed group than the control group from T20 to T120 (P   =   0.002 at T20, P   <   0.001 at the other times). CONCLUSION: Pre-warming for 30  minutes at 38  C did not modify the trends of the temperature decrease seen in the INR suite. It just slightly elevated the beginning post intubation base temperature. The rate of decrease was similar from T20 to T120. However, pre-warming considerably reduced the risk of intraprocedural @entity2332 . TRIAL REGISTRATION: Clinical Research Information Service (CRiS) Identifier: KCT0001320. Registered December 19th, 2014.

title: The efficacy of pre-warming on reducing intraprocedural XXXX in endovascular coiling of @entity438 .

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['cerebral aneurysms']

answer: @entity2332 :: (MESH:D007035,Disease) :: ['hypothermia']


abstract: BACKGROUND: The anesthetic management of @entity1 undergoing endovascular treatment of @entity438 in the interventional neuroradiology suite can be challenged by @entity2332 because of low ambient temperature for operating and maintaining its equipments. We evaluated the efficacy of skin surface warming prior to induction of anesthesia to prevent the decrease in core temperature and reduce the incidence of @entity2332 . METHODS: Seventy-two @entity1 were randomized to pre-warmed and control group. The @entity1 in pre-warmed group were warmed 30  minutes before induction with a forced-air warming blanket set at 38  C. Pre-induction tympanic temperature (Tpre) was measured using an infrared tympanic thermometer and core temperature was measured at the esophagus immediately after intubation (T0) and recorded at 20  minutes intervals (T20, T40, T60, T80, T100, and T120). The number of @entity1 who became hypothermic at each time was recorded. RESULTS: Tpre in the control and pre-warmed group were 36.4        0.4  C and 36.6        0.3  C, whereas T0 were 36.5        0.4  C and 36.6        0.2  C. Core temperatures in the pre-warmed group were significantly higher than the control group at T20, T40, T60, T80, T100, and T120 (P   <   0.001). Compared to T0, core temperatures at each time were significantly lower in both two groups (P   =   0.007 at T20 in pre-warmed group, P   <   0.001 at the other times in both groups). The incidence of @entity2332 was significantly lower in the pre-warmed group than the control group from T20 to T120 (P   =   0.002 at T20, P   <   0.001 at the other times). CONCLUSION: Pre-warming for 30  minutes at 38  C did not modify the trends of the temperature decrease seen in the INR suite. It just slightly elevated the beginning post intubation base temperature. The rate of decrease was similar from T20 to T120. However, pre-warming considerably reduced the risk of intraprocedural @entity2332 . TRIAL REGISTRATION: Clinical Research Information Service (CRiS) Identifier: KCT0001320. Registered December 19th, 2014.

title: The efficacy of pre-warming on reducing intraprocedural @entity2332 in endovascular coiling of XXXX .

answer: @entity438 :: (MESH:D002532,Disease) :: ['cerebral aneurysms']


abstract: Shiga toxin-producing @entity526 O157:H7 (O157) are significant foodborne pathogens and pose a serious threat to public health worldwide. The major reservoirs of O157 are asymptomatic @entity291 which harbor the organism in the terminal recto-anal junction (RAJ). Some colonized animals, referred to as "super-shedders" ( @entity6629 ), are known to shed O157 in exceptionally large numbers (>104 CFU/g of feces). Recent studies suggest that @entity6629 @entity291 play a major role in the prevalence and transmission of O157, but little is known about the molecular mechanisms associated with super-shedding. Whole genome sequence analysis of an @entity6629 O157 strain (SS17) revealed a genome of 5,523,849 bp chromosome with 5,430 open reading frames and two plasmids, pO157 and pSS17, of 94,645 bp and 37,446 bp, respectively. Comparative analyses showed that SS17 is clustered with @entity2772 -associated O157 outbreak strains, and belongs to the lineage I/II, clade 8, D group, and genotype 1, a subgroup of O157 with predicted @entity2915 . A large number of non-synonymous SNPs and other polymorphisms were identified in SS17 as compared with other O157 strains (EC4115, EDL933, Sakai, TW14359), including in key adherence- and virulence-related loci. Phenotypic analyses revealed a distinctive and strongly adherent aggregative phenotype of SS17 on @entity291 @entity1544 ( @entity1544 ) cells that was conserved amongst other @entity6629 isolates. Molecular genetic and functional analyses of defined mutants of SS17 suggested that the strongly adherent aggregative phenotype amongst @entity6629 isolates is LEE-independent, and likely results from a novel mechanism. Taken together, our study provides a rational framework for investigating the molecular mechanisms associated with @entity6629 , and strong evidence that @entity6629 O157 isolates have distinctive features and use a LEE-independent mechanism for hyper-adherence to @entity291 rectal epithelial cells.

title: Comparative Analysis of Super-Shedder Strains of XXXX O157:H7 Reveals Distinctive Genomic Features and a Strongly Aggregative Adherent Phenotype on @entity291 Rectoanal Junction Squamous Epithelial Cells.

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['RSE', 'RAJ stratified squamous epithelial']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyper-virulence']

answer: @entity526 :: (562,Species) :: ['Escherichia coli']


abstract: Shiga toxin-producing @entity526 O157:H7 (O157) are significant foodborne pathogens and pose a serious threat to public health worldwide. The major reservoirs of O157 are asymptomatic @entity291 which harbor the organism in the terminal recto-anal junction (RAJ). Some colonized animals, referred to as "super-shedders" ( @entity6629 ), are known to shed O157 in exceptionally large numbers (>104 CFU/g of feces). Recent studies suggest that @entity6629 @entity291 play a major role in the prevalence and transmission of O157, but little is known about the molecular mechanisms associated with super-shedding. Whole genome sequence analysis of an @entity6629 O157 strain (SS17) revealed a genome of 5,523,849 bp chromosome with 5,430 open reading frames and two plasmids, pO157 and pSS17, of 94,645 bp and 37,446 bp, respectively. Comparative analyses showed that SS17 is clustered with @entity2772 -associated O157 outbreak strains, and belongs to the lineage I/II, clade 8, D group, and genotype 1, a subgroup of O157 with predicted @entity2915 . A large number of non-synonymous SNPs and other polymorphisms were identified in SS17 as compared with other O157 strains (EC4115, EDL933, Sakai, TW14359), including in key adherence- and virulence-related loci. Phenotypic analyses revealed a distinctive and strongly adherent aggregative phenotype of SS17 on @entity291 @entity1544 ( @entity1544 ) cells that was conserved amongst other @entity6629 isolates. Molecular genetic and functional analyses of defined mutants of SS17 suggested that the strongly adherent aggregative phenotype amongst @entity6629 isolates is LEE-independent, and likely results from a novel mechanism. Taken together, our study provides a rational framework for investigating the molecular mechanisms associated with @entity6629 , and strong evidence that @entity6629 O157 isolates have distinctive features and use a LEE-independent mechanism for hyper-adherence to @entity291 rectal epithelial cells.

title: Comparative Analysis of Super-Shedder Strains of @entity526 O157:H7 Reveals Distinctive Genomic Features and a Strongly Aggregative Adherent Phenotype on XXXX Rectoanal Junction Squamous Epithelial Cells.

answer: @entity291 :: (9913,Species) :: ['Bovine']


abstract: AIM: We have previously reported that early phase (1   week) of experimental @entity1284 ( @entity1284 ) has an adaptive phenotype while wall stress-matched pressure overload (PO) is maladaptive. Here we investigate the transition from adaptation to @entity712 ( @entity712 ) in long-term @entity1284 . METHODS AND RESULTS: FVB/N wild-type @entity19 were subjected to @entity1284 induced by aortocaval shunt, and were followed by serial echocardiography until in vivo left ventricular ejection fraction was below <50% (135        35   days). @entity712 was evident from increased lung and liver weight and increased mortality compared with sham. Maladaptive remodelling resulted in significantly reduced sarcomeric @entity22405 phosphorylation (causing increased sarcomeric stiffness), whereas @entity82 was not increased. This was paralleled by re-expression of the fetal gene program, activation of @entity460 /calmodulin-dependent protein kinase II (CaMKII), decreased protein kinase B ( @entity1994 ) phosphorylation, high oxidative stress, and increased apoptosis. Consistently, development of @entity712 and mortality were significantly aggravated in @entity1994 -deficient @entity19 . CONCLUSION: Transition to @entity712 in @entity1284 is associated with decreased @entity1994 and increased CaMKII signalling pathways together with increased oxidative stress and apoptosis. Lack of @entity82 together with sarcomeric @entity22405 hypophosphorylation indicates an increased stiffness at the sarcomeric but not matrix level in @entity1284 -induced @entity712 (in contrast to PO). Transition to @entity712 may result from myocyte loss and @entity409 owing to increased stiffness.

title: Molecular and structural transition mechanisms in long-term XXXX .

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'Heart failure', 'heart failure']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['myocyte dysfunction']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity1284 :: ('MESH:D019190', 'Disease') :: ['VO', 'volume overload']

answer: @entity1284 :: (MESH:D019190,Disease) :: ['volume overload']


abstract: BACKGROUND: Nodal staging is crucial in determining the use of adjuvant chemotherapy for @entity694 . The number of metastatic lymph nodes has been positively correlated with the number of lymph nodes examined. Current guidelines recommend that at minimum 12 to 14 lymph nodes be assessed. In some studies, @entity5527 has been associated with lymph node yield. OBJECTIVE: The purpose of this work was to determine whether mismatch repair-deficient @entity14 are associated with increased lymph node yield. DESIGN: We queried an institutional database to analyze colectomy specimens with immunohistochemistry for mismatch repair genes in @entity1 treated for @entity14 between 1999 and 2012. Before 2006, immunohistochemistry was performed at the request of an oncologist or surgeon. After 2006, it was routinely performed for @entity1 <50 years of age. We measured the association of clinical and pathologic features with lymph node quantity. Fourteen predictors and confounders were jointly analyzed in a multivariable linear regression model. SETTINGS: The study was conducted at a single tertiary care institution. @entity1 : Tissue specimens from 256 @entity1 were reviewed. MAIN OUTCOME MEASURES: The correlation of @entity5 , @entity1 , and operative variables to the yield of mesenteric lymph nodes was measured. RESULTS: Of 256 colectomy specimens reviewed, 94 had @entity5527 . On univariate analysis, @entity5527 was associated with lower lymph node yield, older @entity1 age, right-sided @entity5 , and poor differentiation. The linear regression model identified 5 variables with independent relationships to lymph node yield, including @entity1 age, specimen length, lymph node ratio, perineural invasion, and @entity5 size. A positive correlation was observed with @entity5 size, specimen length, and perineural invasion. @entity5 location had a more complex, nonlinear, quadratic relationship with lymph node yield; proximal @entity5 were associated with a higher yield than more distal lesions. @entity5527 was not independently associated with lymph node yield. LIMITATIONS: Mismatch repair immunohistochemistry based on @entity1 age, family history, and pathologic features may reduce the generalizability of these results. Our sample size was too small to identify variables with small measures of effect. The retrospective nature of the study did not permit a true assessment of the extent of mesenteric resection. CONCLUSIONS: @entity1 age, length of bowel resected, lymph node ratio, perineural invasion, @entity5 size, and @entity5 location were significant predictors of lymph node yield. However, when controlling for surgical and pathologic factors, mismatch repair protein expression did not predict lymph node yield.

title: Lymph node yield after colectomy for XXXX : is absence of mismatch repair a factor?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'Patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity5527 :: ('MESH:C536928', 'Disease') :: ['mismatch repair deficiency', 'Mismatch repair deficiency']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal tumors', 'colorectal cancer']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: BACKGROUND: Colonic stenting has failed to show an improvement in mortality rates in comparison with emergency surgery for @entity697 . However, it remains unclear which @entity1 are more likely to benefit from this procedure. OBJECTIVE: The aim of this study is to identify factors that may be predictive of successful outcome of colonic stenting in @entity697 . DESIGN: All @entity1 undergoing colonic stenting for @entity697 between 1999 and 2013 were studied. The demographics and characteristics of the obstructing lesion were analyzed. SETTINGS: This investigation was conducted at a district general hospital. @entity1 : A total of 126 (76 @entity1 ; median age, 76 y; range, 42-94 y) with @entity697 were included in the analysis. INTERVENTION: The insertion of a self-expanding metal stent was attempted for each @entity1 to relieve the obstruction. MAIN OUTCOME MEASURES: The primary outcomes measured were technical success in the deployment of the stent, clinical decompression, and perforation rates. RESULTS: Technical deployment of the stent was accomplished in 108 of 126 (86%) @entity1 ; however, only 89 (70%) achieved clinical decompression. Successful deployment and clinical decompression was associated with @entity14 (p = 0.03), shorter strictures (p = 0.01), and wider angulation distal to the obstruction (p = 0.049). Perforation was associated with longer strictures (p = 0.03) LIMITATIONS:: This study was limited by its retrospective nature. CONCLUSION: Colonic stenting in @entity697 is more likely to be successful in shorter, malignant strictures with less angulation distal to the obstruction. Longer benign strictures are less likely to be successful and may be associated with an increased risk of perforation.

title: Predictive factors for successful colonic stenting in XXXX : a 15-year cohort analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute large-bowel obstruction']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute large-bowel obstruction']


abstract: UNASSIGNED: @entity2 is the second most prevalent @entity5 . Spinal metastases are found in 30-90% of @entity1 with @entity204 attributed to @entity5 . Due to bony destruction caused by metastases, surgical intervention is often required to restore spinal alignment and stability. While some research suggests that @entity1841 may possess tumorigenic effects, other studies show possible inhibition of @entity5 growth. Thirty-six athymic @entity35 underwent intraosseous injection of lung @entity420 cells into the L5 vertebral body. Cells were pre-treated with vehicle control (Group A) or rhBMP-2 (Group B) prior to implantation. At 4 weeks post-implantation, in vivo bioluminescent imaging (BLI) was performed to confirm presence of @entity5 and quantify signal. Plain radiographs and microComputed Tomography (microCT) were employed to establish and quantitate osteolysis. Histological analysis characterized pathologic changes in the vertebral body. At 4 weeks post-implantation, BLI showed focal signal in the L5 vertebral body in 93% of Group A animals and 89% of Group B animals. Average @entity5 burden by BLI radiance was 7.43   *   10(3) p/s/cm(2) /sr (Group A) and 1.11   *   10(4) p/s/cm(2) /sr (Group B). Radiographs and microCT demonstrated osteolysis in 100% of animals showing focal BLI signal. MicroCT demonstrated significant @entity604 in both groups compared to age-matched controls but no difference between study groups. Histological analysis confirmed @entity5 invasion in the L5 vertebral body. These findings provide a reliable in vivo model to study isolated spinal metastases from @entity2 . Statement of Clinical Significance: The data support the notion that exposure to rhBMP-2 does not promote the growth of A549 @entity2 spine lesions. This article is protected by copyright. All rights reserved.

title: The effect of recombinant @entity1 @entity1841 on a novel XXXX spine metastasis model in rodents.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['Lung cancer', 'lung cancer']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: UNASSIGNED: @entity2 is the second most prevalent @entity5 . Spinal metastases are found in 30-90% of @entity1 with @entity204 attributed to @entity5 . Due to bony destruction caused by metastases, surgical intervention is often required to restore spinal alignment and stability. While some research suggests that @entity1841 may possess tumorigenic effects, other studies show possible inhibition of @entity5 growth. Thirty-six athymic @entity35 underwent intraosseous injection of lung @entity420 cells into the L5 vertebral body. Cells were pre-treated with vehicle control (Group A) or rhBMP-2 (Group B) prior to implantation. At 4 weeks post-implantation, in vivo bioluminescent imaging (BLI) was performed to confirm presence of @entity5 and quantify signal. Plain radiographs and microComputed Tomography (microCT) were employed to establish and quantitate osteolysis. Histological analysis characterized pathologic changes in the vertebral body. At 4 weeks post-implantation, BLI showed focal signal in the L5 vertebral body in 93% of Group A animals and 89% of Group B animals. Average @entity5 burden by BLI radiance was 7.43   *   10(3) p/s/cm(2) /sr (Group A) and 1.11   *   10(4) p/s/cm(2) /sr (Group B). Radiographs and microCT demonstrated osteolysis in 100% of animals showing focal BLI signal. MicroCT demonstrated significant @entity604 in both groups compared to age-matched controls but no difference between study groups. Histological analysis confirmed @entity5 invasion in the L5 vertebral body. These findings provide a reliable in vivo model to study isolated spinal metastases from @entity2 . Statement of Clinical Significance: The data support the notion that exposure to rhBMP-2 does not promote the growth of A549 @entity2 spine lesions. This article is protected by copyright. All rights reserved.

title: The effect of recombinant @entity1 XXXX on a novel @entity2 spine metastasis model in rodents.

answer: @entity1841 :: (650,Gene) :: ['bone morphogenetic protein-2']


abstract: UNASSIGNED: @entity2 is the second most prevalent @entity5 . Spinal metastases are found in 30-90% of @entity1 with @entity204 attributed to @entity5 . Due to bony destruction caused by metastases, surgical intervention is often required to restore spinal alignment and stability. While some research suggests that @entity1841 may possess tumorigenic effects, other studies show possible inhibition of @entity5 growth. Thirty-six athymic @entity35 underwent intraosseous injection of lung @entity420 cells into the L5 vertebral body. Cells were pre-treated with vehicle control (Group A) or rhBMP-2 (Group B) prior to implantation. At 4 weeks post-implantation, in vivo bioluminescent imaging (BLI) was performed to confirm presence of @entity5 and quantify signal. Plain radiographs and microComputed Tomography (microCT) were employed to establish and quantitate osteolysis. Histological analysis characterized pathologic changes in the vertebral body. At 4 weeks post-implantation, BLI showed focal signal in the L5 vertebral body in 93% of Group A animals and 89% of Group B animals. Average @entity5 burden by BLI radiance was 7.43   *   10(3) p/s/cm(2) /sr (Group A) and 1.11   *   10(4) p/s/cm(2) /sr (Group B). Radiographs and microCT demonstrated osteolysis in 100% of animals showing focal BLI signal. MicroCT demonstrated significant @entity604 in both groups compared to age-matched controls but no difference between study groups. Histological analysis confirmed @entity5 invasion in the L5 vertebral body. These findings provide a reliable in vivo model to study isolated spinal metastases from @entity2 . Statement of Clinical Significance: The data support the notion that exposure to rhBMP-2 does not promote the growth of A549 @entity2 spine lesions. This article is protected by copyright. All rights reserved.

title: The effect of recombinant XXXX @entity1841 on a novel @entity2 spine metastasis model in rodents.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: @entity130 outcomes are improved by protocols for @entity548 , typically activated after physician evaluation at a hospital. Previous analysis suggested that prehospital vital signs contained patterns indicating the presence or absence of @entity548 . In an observational study of adults (aged >= 18 years) transported to level I @entity130 centers by helicopter, we investigated the diagnostic performance of the Automated Processing of the Physiological Registry for Assessment of Injury Severity (APPRAISE) system, a computational platform for real-time analysis of vital signs, for identification of @entity548 in @entity130 @entity1 with explicitly @entity548 . We studied 209 subjects prospectively and 646 retrospectively. In our multivariate analysis, prospective performance was not significantly different from retrospective. The APPRAISE system was 76% sensitive for 24-h packed red blood cells of 9 or more units (95% confidence interval, 59% - 89%) and significantly more sensitive (P < 0.05) than any prehospital Shock Index of 1.4 or higher; sensitivity, 59%; initial systolic blood pressure (SBP) less than 110 mmHg, 50%; and any prehospital SBP less than 90 mmHg, 50%. The APPRAISE specificity for 24-h packed red blood cells of 0 units was 87% (88% for any Shock Index >= 1.4, 88% for initial SBP <110 mmHg, and 90% for any prehospital SBP <90 mmHg). Median APPRAISE hemorrhage notification time was 20 min before arrival at the @entity130 center. In conclusion, APPRAISE identified @entity548 before @entity130 center arrival. En route, this capability could allow medics to focus on direct @entity1 care rather than the monitor and, via advance radio notification, could expedite hospital interventions for @entity1 with substantial @entity190 .

title: Automated analysis of vital signs to identify @entity1 with XXXX before hospital arrival: a feasibility study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'substantial bleeding', 'hemorrhagic injuries']

answer: @entity548 :: (MESH:D006470,Disease) :: ['substantial bleeding']


abstract: @entity130 outcomes are improved by protocols for @entity548 , typically activated after physician evaluation at a hospital. Previous analysis suggested that prehospital vital signs contained patterns indicating the presence or absence of @entity548 . In an observational study of adults (aged >= 18 years) transported to level I @entity130 centers by helicopter, we investigated the diagnostic performance of the Automated Processing of the Physiological Registry for Assessment of Injury Severity (APPRAISE) system, a computational platform for real-time analysis of vital signs, for identification of @entity548 in @entity130 @entity1 with explicitly @entity548 . We studied 209 subjects prospectively and 646 retrospectively. In our multivariate analysis, prospective performance was not significantly different from retrospective. The APPRAISE system was 76% sensitive for 24-h packed red blood cells of 9 or more units (95% confidence interval, 59% - 89%) and significantly more sensitive (P < 0.05) than any prehospital Shock Index of 1.4 or higher; sensitivity, 59%; initial systolic blood pressure (SBP) less than 110 mmHg, 50%; and any prehospital SBP less than 90 mmHg, 50%. The APPRAISE specificity for 24-h packed red blood cells of 0 units was 87% (88% for any Shock Index >= 1.4, 88% for initial SBP <110 mmHg, and 90% for any prehospital SBP <90 mmHg). Median APPRAISE hemorrhage notification time was 20 min before arrival at the @entity130 center. In conclusion, APPRAISE identified @entity548 before @entity130 center arrival. En route, this capability could allow medics to focus on direct @entity1 care rather than the monitor and, via advance radio notification, could expedite hospital interventions for @entity1 with substantial @entity190 .

title: Automated analysis of vital signs to identify XXXX with @entity548 before hospital arrival: a feasibility study.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: INTRODUCTION: @entity1119 is a debilitating problem that is not only uncomfortable and inconvenient, but also embarrassing in work and social situations. In spite of the availability of several options for the treatment of axillary @entity1119 , recently, there has been an increasing interest in the use of laser therapy. This study aims to evaluate the efficacy of a laser diode device emitting at wavelengths of 924 and 975   nm and classical curettage either alone, simultaneously or in combination. MATERIAL AND METHODS: A randomized prospective controlled trial was carried out on 100 @entity1 divided into four groups, each with a different protocol: Laser alone at 975   nm (group 1), laser alone at 924/975   nm simultaneously (group 2), curettage alone (group 3), and finally laser at 924/975   nm followed by curettage (group 4). HDSS, starch test and GAIS were used to assess treatment efficacy. The follow-up extended to one year. Statistical analysis (SPSS) was used to determine the accuracy of the results. RESULT:: Two @entity1 of group 1 experienced burns during treatment, which took over a month to heal. This group of @entity1 achieved the worst results: The starch test scale results after treatment were 2.48        0.51 and 2.76        0.44 (at 1 and 12 months). The GAIS results were 1.04        0.35 and 0.92        0.28 (1 and 12 months). In group 2 the starch test scale results after treatment were 1.36        0.49 and 1.48        0.51 (at 1 and 12 months). The GAIS results were 2.36        0.49 and 2.72        0.46 (at 1 and 12 months). In group 3, the starch test scale results after treatment were 1.56        0.51 and 1.76        0.60 (at 1 and 12 months), which corresponds to small to substantially smaller dark areas. The GAIS results were 2.28        0.46 and 2.64        0.49 (at 1 and 12 months). The best results were obtained in group 4: HDSS scores were reduced from 3.88        0.33 before treatment to 1.24        0.44 and 0.48        0.51 at the 1 and 12 months controls. The starch test scale results after treatment were 0.40        0.50 and 0.44        0.51 (at 1 and 12 months). The GAIS results were 3.72        0.54 and 3.76        0.44 (at 1 and 12 months). CONCLUSION:: In this study, the laser at 924/975   nm combined with curettage was determined to be the optimal treatment option of those tested for axillary @entity1119 . This treatment was safe, with few side effects and improvement that persisted to one year follow-up. Lasers Surg. Med.    2015 Wiley Periodicals, Inc.

title: Efficacy and safety of laser therapy on axillary XXXX after one year follow-up: A randomised blinded controlled trial.

entities_list: @entity1119 :: ('MESH:D006945', 'Disease') :: ['hyperhidrosis', 'Hyperhidrosis']

answer: @entity1119 :: (MESH:D006945,Disease) :: ['hyperhidrosis']


abstract: BACKGROUND: Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. @entity177 is associated with worse outcomes in various acute @entity16 . An integrative approach is presently used according to the existing paradigm for the association of series of temporal @entity73 with the outcomes of @entity1 with @entity131 ( @entity131 ). OBJECTIVE: To explore the influence of the duration of @entity73 events on severe @entity131 @entity1 outcomes. @entity1 age was also included in the analysis of the prospectively collected clinical data. METHODS: CA monitoring included 33 prospective severe @entity131 @entity1 . The pressure reactivity index [ @entity10166 (t)] was continuously monitored to collect information on the dynamics of CA status and to analyze associations between the duration of the longest @entity73 event and @entity1 outcomes. RESULTS: The Glasgow outcome scale and the duration of the longest @entity73 were negatively correlated. The duration of autoregulation impairment significantly correlated with worse outcomes. Multidimensional representation of Glasgow outcome scale plots showed that better outcomes were obtained for younger @entity1 (age < 47 years) and those whose longest @entity73 event was shorter than 40 minutes if @entity10166 (t) was above 0.7 in the @entity73 event. CONCLUSION: Unfavorable outcomes for @entity131 @entity1 are more significantly associated with the duration of the single longest @entity73 episode at a high @entity10166 (t) value, rather than with averaged @entity10166 (t) values or the average time of all @entity73 episodes. ABBREVIATIONS: ABP, arterial blood pressureABP(t), continuous reference arterial blood pressureCA, cerebrovascular autoregulationCBF, cerebral blood flowCPP, cerebral perfusion pressureGOS, Glasgow outcome scaleGOSHD, Glasgow outcome scale after hospital dischargeGOS6M, Glasgow outcome scale at 6 months after dischargeICP, intracranial pressureICP(t), continuously monitored intracranial pressureLCAI, longest CA impairmentoptCPP, optimal cerebral perfusion pressurePRx(t), pressure reactivity indexTBI, @entity131 .

title: Association of Severe XXXX @entity1 Outcomes With Duration of Cerebrovascular Autoregulation Impairment Events.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['CA impairment', 'CA impairments']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological diseases']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['Temporal CA failure']

answer: @entity131 :: (MESH:D001930,Disease) :: ['Traumatic Brain Injury']


abstract: BACKGROUND: Cerebrovascular autoregulation (CA) is an important hemodynamic mechanism that protects the brain against inappropriate fluctuations in cerebral blood flow in the face of changing cerebral perfusion pressure. @entity177 is associated with worse outcomes in various acute @entity16 . An integrative approach is presently used according to the existing paradigm for the association of series of temporal @entity73 with the outcomes of @entity1 with @entity131 ( @entity131 ). OBJECTIVE: To explore the influence of the duration of @entity73 events on severe @entity131 @entity1 outcomes. @entity1 age was also included in the analysis of the prospectively collected clinical data. METHODS: CA monitoring included 33 prospective severe @entity131 @entity1 . The pressure reactivity index [ @entity10166 (t)] was continuously monitored to collect information on the dynamics of CA status and to analyze associations between the duration of the longest @entity73 event and @entity1 outcomes. RESULTS: The Glasgow outcome scale and the duration of the longest @entity73 were negatively correlated. The duration of autoregulation impairment significantly correlated with worse outcomes. Multidimensional representation of Glasgow outcome scale plots showed that better outcomes were obtained for younger @entity1 (age < 47 years) and those whose longest @entity73 event was shorter than 40 minutes if @entity10166 (t) was above 0.7 in the @entity73 event. CONCLUSION: Unfavorable outcomes for @entity131 @entity1 are more significantly associated with the duration of the single longest @entity73 episode at a high @entity10166 (t) value, rather than with averaged @entity10166 (t) values or the average time of all @entity73 episodes. ABBREVIATIONS: ABP, arterial blood pressureABP(t), continuous reference arterial blood pressureCA, cerebrovascular autoregulationCBF, cerebral blood flowCPP, cerebral perfusion pressureGOS, Glasgow outcome scaleGOSHD, Glasgow outcome scale after hospital dischargeGOS6M, Glasgow outcome scale at 6 months after dischargeICP, intracranial pressureICP(t), continuously monitored intracranial pressureLCAI, longest CA impairmentoptCPP, optimal cerebral perfusion pressurePRx(t), pressure reactivity indexTBI, @entity131 .

title: Association of Severe @entity131 XXXX Outcomes With Duration of Cerebrovascular Autoregulation Impairment Events.

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: BACKGROUND: Conventional systematic biopsy has the shortcoming of sampling error and reveals "no evidence of @entity5 " with a rate of >50% on @entity3457 ( @entity3457 ). The objective of this study is to report our initial experience of applying a 3D-documented biopsy-mapping technology to precisely re-visit geographically documented @entity263 and to perform serial analysis of cell-cycle-progression (CCP) gene-panel. METHODS: Over a period of 40 months (1/2010-4/2013), the 3D-biopsy-mapping technique, in which the spatial location of biopsy-trajectory was digitally recorded (Koelis), was carried out. A pair of diagnostic (1st-look) and surveillance (2nd-look) biopsy were performed per subject (n   =   25), with median interval of 12 months. The documented biopsy-trajectory was used as a target to guide the re-visiting biopsy from the documented @entity5 focus, as well as the targeted field-biopsy from the un-sampled prostatic field adjacent to negative diagnostic biopsies. The accuracy of re-visiting biopsy and biopsy-derived CCP signatures were evaluated in the pair of the serial biopsy-cores. RESULTS: The 1st-look-biopsy revealed a total of 43 @entity5 (1.7 per @entity1 ). The accuracy of re-visiting @entity5 was 86% (37/43) per lesion, 76% (65/86) per core, and 80% (20/25) per @entity1 . This technology also provided an opportunity for 3D-targeted field-biopsy in order to potentially minimize sampling errors. The CCP gene-panel of the 1st-look (-0.59) versus 2nd-look (-0.37) samples had no significant difference (P   =   0.4); which suggested consistency in the molecular signature of the known @entity5 foci during the short-time interval of median 12 months. Any change in CCP of the same @entity5 foci would be likely due to change in sampling location from the less to more significant portion in the @entity5 foci rather than true molecular progression. The study limitations include a small number of the @entity1 . CONCLUSION: The 3D-documented biopsy-mapping technology achieved an encouraging re-sampling accuracy of 86% from the known @entity263 foci, allowing the serial analysis of biopsy-derived CCP signatures. Prostate    2015 Wiley Periodicals, Inc.

title: A novel technique using three-dimensionally documented biopsy mapping allows precise XXXX foci with serial surveillance of cell cycle progression gene panel.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'cancer lesions']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'low-risk prostate cancer']

entities_list: @entity3457 :: ('OMIM:612348', 'Disease') :: ['active surveillance', 'AS']

answer: @entity263 :: (MESH:D011471,Disease) :: ['re-visiting of prostate cancer']


abstract: BACKGROUND: The worldwide epidemic of @entity164 2 @entity6 (T2DM) underlines the need for @entity6 prevention strategies. In this study the feasibility and effectiveness of a nurse led lifestyle program for subjects with impaired fasting @entity413 (IFG) is assessed. METHODS: A cluster randomized clinical trial in 26 primary care practices in the Netherlands included 366 @entity1 older than 45  years with newly diagnosed IFG and motivated to change their lifestyle (intervention group, n   =   197; usual care group, n   =   169). The one-year intervention, consisting of four to five individual nurse-led consultations, was directed at improving physical activity and dietary habits. The primary outcome measure was body mass index (BMI). Linear and logistic multilevel analyses and a process evaluation were performed. RESULTS: Both groups showed small reductions in BMI at 1 and 2  years, but differences between groups were not significant. At both 1 and 2-year follow-up the number of @entity1 physically active for at least 30  minutes at least five days a week was significantly improved in the intervention group compared to the usual care group (intervention group vs. usual care group: OR1year   =   3.53; 95  % CI   =   1.69-7.37 and OR2years   =   1.97; 95  % CI   =   1.22-3.20, respectively). The total drop-out rate was 24  %. Process evaluation revealed that @entity1 in the intervention group received fewer consultations than advised, while some practice nurses and @entity1 considered the RM protocol too intensive. CONCLUSIONS: This relatively simple lifestyle program in subjects with IFG resulted in a significant improvement in reported physical activity, but not in BMI. Despite its simplicity, some @entity1 still considered the intervention too intensive. This viewpoint could be related to poor motivation and an absence of disease burden due to IFG, such that @entity1 do not feel a need for behavioural change. Although the intervention provided some benefit, its wider use cannot be advised. TRIAL REGISTRATION: Current Controlled Trials ISRCTN41209683 , date of registration 16/10/2013h   .

title: Effects of a lifestyle program in subjects with Impaired Fasting XXXX , a pragmatic cluster-randomized controlled trial.

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity413 :: (MESH:D005947,Chemical) :: ['Glucose']


abstract: UNASSIGNED: MicroRNAs (miRNA, @entity11216 ) have been implicated as promising blood-based biomarkers for @entity161 @entity1 . This study aimed to clinically validate miRNA as potential @entity161 biomarkers. Plasma levels of 10 miRNAs were analyzed using qPCR in a cohort of 61 @entity161 @entity1 and 62 normal controls, as well as 25 @entity1 particularly selected for a six-week antipsychotic treatment course. Positive And Negative Syndrome Scale (PANSS), Global Assessment Scale (GAS) and Clinical Global Impression (CGI) were administered to assess the clinical symptoms. The results demonstrated that a panel of miRNAs consisting of @entity68191 , @entity11216 -181b, @entity7762 , @entity68048 and @entity12333 had significantly increased expression levels with significant combined diagnostic value (AUC:0.713; sensitivity:35.5%; specificity:90.2%). In response to pharmacological treatment, expression levels of @entity24341 , @entity11216 -181b, @entity61459 and @entity68191 were significantly decreased. In addition, the improvement of clinical symptomatology was significantly correlated with the changes of @entity24341 , @entity11216 -181b, @entity31611 and @entity68191 expression levels. Furthermore, the decreases of plasma levels of @entity24341 and @entity61459 were significantly greater in high-effect subgroup than those in low-effect subgroup after six-week treatment course. We conclude that @entity68191 , @entity11216 -181b, @entity7762 , @entity68048 and @entity12333 combined as a panel are potentially useful non-invasive biomarkers for @entity161 diagnosis. Markers @entity24341 , @entity11216 -181b, @entity68191 and @entity61459 are potential indicators for symptomatology improvements, treatment responses and prognosis for @entity161 @entity1 .    2015 Wiley Periodicals, Inc.

title: A preliminary analysis of microRNA as potential clinical biomarker for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: UNASSIGNED: Abstract Objectives: Around 40% of @entity6 @entity1 have lowered testosterone and symptoms of @entity6126 but the prevalence of @entity6126 among @entity5710 @entity1 is unknown. The aim of this study was to investigate the prevalence of late-onset @entity6126 (LOH) in population of Polish @entity1 with @entity5710 . Methods: This study was performed in 196 @entity5710 @entity1 and in 184 normoglycemic, control group. @entity5710 was defined as impaired fasting @entity13897 , @entity13897 and/or HbA1c 5.7-6.4%. LOH was defined as low libido, diminished frequency of morning erections and @entity323 in @entity1 with total testosterone <12   nmol/l. Results: Total testosterone (TT) level in @entity5710 group was 11.78        1.76 and 16.37        1.6   nmol/l in control group (p   <   0.001). LOH was diagnosed in 30% @entity5710 @entity1 and in 13.6% control @entity1 . There were negative relationships between calculated free testosterone (cFT) and HbA1c (r   =   -0.3856; p   <   0.005). In @entity5710 group, TT and cFT levels were lower in @entity1 with @entity13897 than impaired fasting @entity13897 (p   <   0.05 and p   <   0.02, respectively). We showed inverse relationships between IIEF-5 score and cFT (r   =   -0.414, p   <   0.005) and between IIEF-5 and HbA1c (r   =   -0.395, p   <   0.002). Conclusions: In population of Polish @entity1 with @entity5710 we observed high prevalence of LOH. Routine testosterone screening should be performed in all @entity5710 @entity1 .

title: Late-onset XXXX among old and middle-aged males with @entity5710 in Polish population.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity13897 :: ('MESH:D018149', 'Disease') :: ['glucose', 'impaired glucose tolerance']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunctions']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity5710 :: ('MESH:D011236', 'Disease') :: ['prediabetes', 'Prediabetes', 'prediabetic']

entities_list: @entity6126 :: ('MESH:D007006', 'Disease') :: ['hypogonadism']

answer: @entity6126 :: (MESH:D007006,Disease) :: ['hypogonadism']


abstract: UNASSIGNED: Abstract Objectives: Around 40% of @entity6 @entity1 have lowered testosterone and symptoms of @entity6126 but the prevalence of @entity6126 among @entity5710 @entity1 is unknown. The aim of this study was to investigate the prevalence of late-onset @entity6126 (LOH) in population of Polish @entity1 with @entity5710 . Methods: This study was performed in 196 @entity5710 @entity1 and in 184 normoglycemic, control group. @entity5710 was defined as impaired fasting @entity13897 , @entity13897 and/or HbA1c 5.7-6.4%. LOH was defined as low libido, diminished frequency of morning erections and @entity323 in @entity1 with total testosterone <12   nmol/l. Results: Total testosterone (TT) level in @entity5710 group was 11.78        1.76 and 16.37        1.6   nmol/l in control group (p   <   0.001). LOH was diagnosed in 30% @entity5710 @entity1 and in 13.6% control @entity1 . There were negative relationships between calculated free testosterone (cFT) and HbA1c (r   =   -0.3856; p   <   0.005). In @entity5710 group, TT and cFT levels were lower in @entity1 with @entity13897 than impaired fasting @entity13897 (p   <   0.05 and p   <   0.02, respectively). We showed inverse relationships between IIEF-5 score and cFT (r   =   -0.414, p   <   0.005) and between IIEF-5 and HbA1c (r   =   -0.395, p   <   0.002). Conclusions: In population of Polish @entity1 with @entity5710 we observed high prevalence of LOH. Routine testosterone screening should be performed in all @entity5710 @entity1 .

title: Late-onset @entity6126 among old and middle-aged males with XXXX in Polish population.

answer: @entity5710 :: (MESH:D011236,Disease) :: ['prediabetes']


abstract: Evoked potentials (EPs) of the dorsal hippocampus were recorded in non-immobilized non-anaesthetized @entity95 before and after tetanization of the medial septum and the dentate fascia. Changes of @entity934 ( @entity1617 ) efficiency were tested during long-lasting potentiation (LLP) and @entity308 ( @entity308 ). Increase in the amplitude of the EP fast component (population spike) during microiontophoresis of @entity1617 was used as an index of @entity1617 efficiency. In various tests both decrease and enhancement of @entity1617 efficiency after tetanization were observed independent of the LLP or @entity308 appearance. "Relative" @entity1617 efficiency in most cases decreased during LLP and enhanced during @entity308 . These changes were nonspecific since they were observed in response to the stimulation of both medial septum (cholinergic input), and dentate fascia (non-cholinergic input). Reactions to the stimulation of the control (non-tetanized) input were mainly depressed with diminution of @entity1617 efficiency. The above experiments do not confirm the hypothesis that LLP and @entity308 are based on respective changes in the sensitivity of the subsynaptic membrane to the transmitter. The most probable LLP mechanism seems to be the enhancement of synaptic efficiency due to increased release of the transmitter. @entity308 mechanisms probably include changes at the level of the postsynaptic membrane and call for further analysis.

title: [Effect of @entity934 on hippocampal response during long-term post-tetanic potentiation and XXXX of the medial septum and dentate gyrus].

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['PTD', 'posttetanic depression']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: Evoked potentials (EPs) of the dorsal hippocampus were recorded in non-immobilized non-anaesthetized @entity95 before and after tetanization of the medial septum and the dentate fascia. Changes of @entity934 ( @entity1617 ) efficiency were tested during long-lasting potentiation (LLP) and @entity308 ( @entity308 ). Increase in the amplitude of the EP fast component (population spike) during microiontophoresis of @entity1617 was used as an index of @entity1617 efficiency. In various tests both decrease and enhancement of @entity1617 efficiency after tetanization were observed independent of the LLP or @entity308 appearance. "Relative" @entity1617 efficiency in most cases decreased during LLP and enhanced during @entity308 . These changes were nonspecific since they were observed in response to the stimulation of both medial septum (cholinergic input), and dentate fascia (non-cholinergic input). Reactions to the stimulation of the control (non-tetanized) input were mainly depressed with diminution of @entity1617 efficiency. The above experiments do not confirm the hypothesis that LLP and @entity308 are based on respective changes in the sensitivity of the subsynaptic membrane to the transmitter. The most probable LLP mechanism seems to be the enhancement of synaptic efficiency due to increased release of the transmitter. @entity308 mechanisms probably include changes at the level of the postsynaptic membrane and call for further analysis.

title: [Effect of XXXX on hippocampal response during long-term post-tetanic potentiation and @entity308 of the medial septum and dentate gyrus].

answer: @entity934 :: (MESH:D000109,Chemical) :: ['acetylcholine']


abstract: BACKGROUND AND PURPOSE: Computed tomographic (CT) @entity536 ( @entity536 ) areas after endovascular therapy for acute @entity385 are a common finding indicative of blood-brain barrier disruption. @entity5748 allows an accurate differentiation between @entity536 areas related to @entity8 ( @entity8 ) or to @entity932 ( @entity932 ). We sought to evaluate the prognostic significance of the presence of @entity8 and @entity932 after endovascular therapy. METHODS: A prospective cohort of 132 @entity1 treated with endovascular therapy was analyzed. According to dual-energy CT findings, @entity1 were classified into 3 groups: no @entity536 areas (n=53), @entity8 (n=32), and @entity932 (n=47). The rate of new @entity548 transformations was recorded at follow-up neuroimaging. Clinical outcome was evaluated at 90 days with the modified Rankin Scale (poor outcome, 3-6). RESULTS: Poor outcome was associated with the presence of @entity8 (odds ratio [OR], 11.3; 95% confidence interval, 3.34-38.95) and @entity932 (OR, 10.4; 95% confidence interval, 3.42-31.68). The rate of poor outcome despite complete recanalization was also significantly higher in @entity8 (OR, 9.7; 95% confidence interval, 2.55-37.18) and @entity932 (OR, 15.1; 95% confidence interval, 3.85-59.35) groups, compared with the no- @entity536 group. @entity1 with @entity8 disclosed a higher incidence of delayed @entity548 transformation at follow-up (OR, 4.5; 95% confidence interval, 1.22-16.37) compared with no- @entity536 @entity1 . CONCLUSIONS: Blood-brain barrier disruption, defined as @entity8 and @entity932 on dual-energy CT, was associated with poor clinical outcomes in @entity1 with @entity64 treated with endovascular therapies. Moreover, isolated @entity8 was associated with delayed @entity548 transformation. These results support the clinical relevance of blood-brain barrier disruption in @entity64 .

title: Relevance of Blood-Brain Barrier Disruption After Endovascular Treatment of XXXX : Dual-Energy Computed Tomographic Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['CS', 'contrast staining']

entities_list: @entity932 :: ('MESH:D020300', 'Disease') :: ['brain hemorrhage', 'BH']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['stroke', 'acute stroke']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhagic']

entities_list: @entity5748 :: ('MESH:D009105', 'Disease') :: ['Dual-energy CT']

entities_list: @entity536 :: ('MESH:C538265', 'Disease') :: ['high attenuation', 'HA']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']