abstract: BACKGROUND: Intramedullary spinal @entity424 are @entity5 . OBJECTIVE: To provide a large retrospective review in the modern neuroimaging era from a tertiary center where aggressive surgical resection is favored. METHODS: Charts of intramedullary spinal @entity424 treated between 1983 and 2006 were reviewed. RESULTS: Sixty-seven cases were reviewed. The mean age was 45.6 years (range, 11-78 years) with a male-to-female ratio of 2:1. The most common location was the cervical spine, followed by the thoracic and lumbar spine. The average duration of symptoms was 33 months, with the most common symptom being @entity158 , followed by @entity425 , @entity1183 , and urinary or sexual symptoms. Gross total resection was achieved in 55 @entity1 and a subtotal resection was performed in 12 @entity1 ; 9 @entity1 were treated with adjuvant radiation therapy. Mean follow-up was 32 months. The mean McCormick neurological grade at last follow-up was 2.0. The preoperative outcome correlated significantly with postoperative outcome (P < .001). A significant number of @entity1 who initially worsened improved at their 3-month follow-up examination. Outcomes were significantly worse in @entity1 undergoing subtotal resection with or without radiation therapy (P < .05). There were 3 recurrences. The overall complication rate was 34%. The primary complications were @entity2737 or @entity5173 . CONCLUSION: Spinal @entity602 are @entity75 to treat. Aggressive surgical resection is associated with a high overall complication rate. However, when gross total resection can be achieved, overall outcomes are excellent and the recurrence rate is low.

title: Surgical technique and outcomes in the treatment of spinal XXXX , part 1: @entity424 .

entities_list: @entity424 :: ('MESH:D004806', 'Disease') :: ['ependymomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rare tumors']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['difficult lesions']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['cord ependymomas']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['wound infections']

entities_list: @entity5173 :: ('MESH:D065634', 'Disease') :: ['cerebrospinal fluid leaks']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain and/or dysesthesias']

answer: @entity602 :: (MESH:D013118,Disease) :: ['cord ependymomas']


abstract: BACKGROUND: Intramedullary spinal @entity424 are @entity5 . OBJECTIVE: To provide a large retrospective review in the modern neuroimaging era from a tertiary center where aggressive surgical resection is favored. METHODS: Charts of intramedullary spinal @entity424 treated between 1983 and 2006 were reviewed. RESULTS: Sixty-seven cases were reviewed. The mean age was 45.6 years (range, 11-78 years) with a male-to-female ratio of 2:1. The most common location was the cervical spine, followed by the thoracic and lumbar spine. The average duration of symptoms was 33 months, with the most common symptom being @entity158 , followed by @entity425 , @entity1183 , and urinary or sexual symptoms. Gross total resection was achieved in 55 @entity1 and a subtotal resection was performed in 12 @entity1 ; 9 @entity1 were treated with adjuvant radiation therapy. Mean follow-up was 32 months. The mean McCormick neurological grade at last follow-up was 2.0. The preoperative outcome correlated significantly with postoperative outcome (P < .001). A significant number of @entity1 who initially worsened improved at their 3-month follow-up examination. Outcomes were significantly worse in @entity1 undergoing subtotal resection with or without radiation therapy (P < .05). There were 3 recurrences. The overall complication rate was 34%. The primary complications were @entity2737 or @entity5173 . CONCLUSION: Spinal @entity602 are @entity75 to treat. Aggressive surgical resection is associated with a high overall complication rate. However, when gross total resection can be achieved, overall outcomes are excellent and the recurrence rate is low.

title: Surgical technique and outcomes in the treatment of spinal @entity602 , part 1: XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity424 :: (MESH:D004806,Disease) :: ['intramedullary ependymomas']


abstract: To obtain rates of mRNA synthesis and decay in @entity375 , we established dynamic transcriptome analysis ( @entity11510 ). @entity11510 combines non-perturbing metabolic RNA labeling with dynamic kinetic modeling. @entity11510 reveals that most mRNA synthesis rates are around several transcripts per cell and cell cycle, and most mRNA half-lives range around a median of 11 min. @entity11510 can monitor the cellular response to osmotic stress with higher sensitivity and temporal resolution than standard transcriptomics. In contrast to monotonically increasing total mRNA levels, @entity11510 reveals three phases of the stress response. During the initial shock phase, mRNA synthesis and decay rates decrease globally, resulting in mRNA storage. During the subsequent induction phase, both rates increase for a subset of genes, resulting in production and rapid removal of stress-responsive mRNAs. During the recovery phase, decay rates are largely restored, whereas synthesis rates remain altered, apparently enabling growth at high salt concentration. Stress-induced changes in mRNA synthesis rates are predicted from gene occupancy with RNA polymerase II. @entity11510 -derived mRNA synthesis rates identified 16 stress-specific pairs/triples of cooperative transcription factors, of which seven were known. Thus, @entity11510 realistically monitors the dynamics in mRNA metabolism that underlie gene regulatory systems.

title: Dynamic transcriptome analysis measures rates of mRNA synthesis and decay in XXXX .

answer: @entity375 :: (4932,Species) :: ['yeast']


abstract: BACKGROUND: Recent research has shown that most of the excess risk of @entity204 following breast and @entity14 in England compared with Norway and Sweden occurs in older age groups during the first year, and especially in the first month of follow-up. The aim of this study was to explore the characteristics of @entity1 dying within 30 days of being diagnosed with one of these @entity5 in Scotland during 2003-2007. METHODS: Anonymised @entity5 registry records linked to hospital discharge and @entity204 records were extracted. The study population was divided into @entity1 who died within 30 days of diagnosis (cases) and those who survived beyond this threshold (controls). Differences in @entity1 -, @entity5 -, and health service-related characteristics were assessed using the   (2)-test and logistic regression. RESULTS: @entity1 dying within 30 days were more likely to be elderly and to have experienced emergency admission to non-surgical specialities. Their @entity5 were less likely to have been verified microscopically, but they appeared more likely to be of high grade and advanced in stage. A substantial number of @entity1 died from causes other than their @entity5 . CONCLUSION: These results suggest that early mortality after a diagnosis of @entity0 may be partly due to comorbidity and lifestyle factors, as well as due to more @entity1442 . Further research is required to determine the precise explanation for these findings and, in particular, if any potentially avoidable factors such as delays in presentation, referral, or diagnosis exist.

title: Characteristics of @entity1 dying within 30 days of diagnosis of XXXX in Scotland, 2003-2007.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast or colorectal cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumours', 'tumour']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast or colorectal cancer']


abstract: BACKGROUND: Recent research has shown that most of the excess risk of @entity204 following breast and @entity14 in England compared with Norway and Sweden occurs in older age groups during the first year, and especially in the first month of follow-up. The aim of this study was to explore the characteristics of @entity1 dying within 30 days of being diagnosed with one of these @entity5 in Scotland during 2003-2007. METHODS: Anonymised @entity5 registry records linked to hospital discharge and @entity204 records were extracted. The study population was divided into @entity1 who died within 30 days of diagnosis (cases) and those who survived beyond this threshold (controls). Differences in @entity1 -, @entity5 -, and health service-related characteristics were assessed using the   (2)-test and logistic regression. RESULTS: @entity1 dying within 30 days were more likely to be elderly and to have experienced emergency admission to non-surgical specialities. Their @entity5 were less likely to have been verified microscopically, but they appeared more likely to be of high grade and advanced in stage. A substantial number of @entity1 died from causes other than their @entity5 . CONCLUSION: These results suggest that early mortality after a diagnosis of @entity0 may be partly due to comorbidity and lifestyle factors, as well as due to more @entity1442 . Further research is required to determine the precise explanation for these findings and, in particular, if any potentially avoidable factors such as delays in presentation, referral, or diagnosis exist.

title: Characteristics of XXXX dying within 30 days of diagnosis of @entity0 in Scotland, 2003-2007.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: With increasing laparoscopic surgery experience and improved new vessel-sealing equipment, @entity302 ( @entity302 ) for splenectomy has emerged as an alternative to multiport laparoscopy, but the application of @entity302 for @entity381 is still challenging due to technical difficulties. The aim of this study was to describe the suture suspension technique contributing to @entity302 for @entity7276 ( @entity7276 ). MATERIALS AND METHODS: A retrospective review was conducted to evaluate all @entity302 for @entity381 performed by a single surgeon. On preoperative ultrasonography, the spleen size index ranged from 0.67 to 0.82. An umbilical incision was used for the placement of a multichannel single port. To provide excellent exposure of the splenic hilum, a needle with a 1-0 suture was percutaneously introduced from the left hypochondriac region and then penetrated out the anterior chest wall for suspending the enlarged spleen. Dissection was facilitated by the use of a 5-mm curved reusable grasper and a 5-mm Harmonic(  ) scalpel (Ethicon Endo-Surgery, Cincinnati, @entity2145 ), and the splenic vessels were ligated with 5-mm Weck(  ) Hem-o-lok(  ) clips (Teleflex(  ), Morrisville, NC). The resected spleen was placed in an endosurgical bag, morcellated, and removed from the abdomen via the umbilical incision. RESULTS: Nine @entity1 underwent @entity302 during the study period without conversion to open procedures or requiring additional ports. The suture suspension technique was successfully used and markedly improved the exposure of the splenic hilum. The operative time was 122.6  31.2 minutes, and the extracted spleen weight was 562  74.5   g (range, 420-1260   g). No intraoperative or postoperative complications were recorded. The umbilical incision healed well with a satisfactory cosmetic effect. CONCLUSIONS: Our outcome shows the suture suspension enables safe and feasible usage of @entity302 for the management of @entity381 in @entity1 with @entity7276 . More experience is needed to assess advantages and disadvantages compared with the standard laparoscopic approach.

title: Single-Incision Laparoscopic Splenectomy Using the Suture Suspension Technique for XXXX in @entity1 with @entity7276 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity7276 :: ('MESH:D013103', 'Disease') :: ['hereditary spherocytosis', 'HS']

entities_list: @entity381 :: ('MESH:D013163', 'Disease') :: ['splenomegaly']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['single-incision laparoscopic surgery', 'SILS']

answer: @entity381 :: (MESH:D013163,Disease) :: ['Splenomegaly']


abstract: BACKGROUND: With increasing laparoscopic surgery experience and improved new vessel-sealing equipment, @entity302 ( @entity302 ) for splenectomy has emerged as an alternative to multiport laparoscopy, but the application of @entity302 for @entity381 is still challenging due to technical difficulties. The aim of this study was to describe the suture suspension technique contributing to @entity302 for @entity7276 ( @entity7276 ). MATERIALS AND METHODS: A retrospective review was conducted to evaluate all @entity302 for @entity381 performed by a single surgeon. On preoperative ultrasonography, the spleen size index ranged from 0.67 to 0.82. An umbilical incision was used for the placement of a multichannel single port. To provide excellent exposure of the splenic hilum, a needle with a 1-0 suture was percutaneously introduced from the left hypochondriac region and then penetrated out the anterior chest wall for suspending the enlarged spleen. Dissection was facilitated by the use of a 5-mm curved reusable grasper and a 5-mm Harmonic(  ) scalpel (Ethicon Endo-Surgery, Cincinnati, @entity2145 ), and the splenic vessels were ligated with 5-mm Weck(  ) Hem-o-lok(  ) clips (Teleflex(  ), Morrisville, NC). The resected spleen was placed in an endosurgical bag, morcellated, and removed from the abdomen via the umbilical incision. RESULTS: Nine @entity1 underwent @entity302 during the study period without conversion to open procedures or requiring additional ports. The suture suspension technique was successfully used and markedly improved the exposure of the splenic hilum. The operative time was 122.6  31.2 minutes, and the extracted spleen weight was 562  74.5   g (range, 420-1260   g). No intraoperative or postoperative complications were recorded. The umbilical incision healed well with a satisfactory cosmetic effect. CONCLUSIONS: Our outcome shows the suture suspension enables safe and feasible usage of @entity302 for the management of @entity381 in @entity1 with @entity7276 . More experience is needed to assess advantages and disadvantages compared with the standard laparoscopic approach.

title: Single-Incision Laparoscopic Splenectomy Using the Suture Suspension Technique for @entity381 in @entity1 with XXXX .

answer: @entity7276 :: (MESH:D013103,Disease) :: ['Hereditary Spherocytosis']


abstract: BACKGROUND: With increasing laparoscopic surgery experience and improved new vessel-sealing equipment, @entity302 ( @entity302 ) for splenectomy has emerged as an alternative to multiport laparoscopy, but the application of @entity302 for @entity381 is still challenging due to technical difficulties. The aim of this study was to describe the suture suspension technique contributing to @entity302 for @entity7276 ( @entity7276 ). MATERIALS AND METHODS: A retrospective review was conducted to evaluate all @entity302 for @entity381 performed by a single surgeon. On preoperative ultrasonography, the spleen size index ranged from 0.67 to 0.82. An umbilical incision was used for the placement of a multichannel single port. To provide excellent exposure of the splenic hilum, a needle with a 1-0 suture was percutaneously introduced from the left hypochondriac region and then penetrated out the anterior chest wall for suspending the enlarged spleen. Dissection was facilitated by the use of a 5-mm curved reusable grasper and a 5-mm Harmonic(  ) scalpel (Ethicon Endo-Surgery, Cincinnati, @entity2145 ), and the splenic vessels were ligated with 5-mm Weck(  ) Hem-o-lok(  ) clips (Teleflex(  ), Morrisville, NC). The resected spleen was placed in an endosurgical bag, morcellated, and removed from the abdomen via the umbilical incision. RESULTS: Nine @entity1 underwent @entity302 during the study period without conversion to open procedures or requiring additional ports. The suture suspension technique was successfully used and markedly improved the exposure of the splenic hilum. The operative time was 122.6  31.2 minutes, and the extracted spleen weight was 562  74.5   g (range, 420-1260   g). No intraoperative or postoperative complications were recorded. The umbilical incision healed well with a satisfactory cosmetic effect. CONCLUSIONS: Our outcome shows the suture suspension enables safe and feasible usage of @entity302 for the management of @entity381 in @entity1 with @entity7276 . More experience is needed to assess advantages and disadvantages compared with the standard laparoscopic approach.

title: Single-Incision Laparoscopic Splenectomy Using the Suture Suspension Technique for @entity381 in XXXX with @entity7276 .

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: A 63-year-old @entity1 with @entity490 was referred to our hospital. Her pancreatic enzymes were elevated, and an abdominal computed tomography (CT) scan showed an enlarged pancreas, consistent with @entity788 , and gas collection containing an impacted stone adjacent to @entity1829 . This finding raised the suspicion of a duodenal diverticulum. A subsequent ERCP showed a juxtapapillary duodenal diverticulum (JPDD) filled with calculi and pus. The @entity788 improved with 2 weeks of conservative treatment. Subsequently, the @entity1 underwent resection of the uterus and bilateral adnexa to remove a large @entity42 that was also identified on the admission CT scan. On the third postoperative day, she developed @entity490 . CT revealed @entity1744 caused by an enterolith expelled from JPDD. Enterotomy was performed to remove the stone. To our knowledge, only three similar cases have been previously reported in Japan.

title: A case of enterolith ileus secondary to acute XXXX associated with a juxtapapillary duodenal diverticulum.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']

entities_list: @entity42 :: ('MESH:D010048', 'Disease') :: ['ovarian cyst']

entities_list: @entity1829 :: ('MESH:D010211', 'Disease') :: ["Vater's papilla"]

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain', 'abdominal pain and vomiting']

entities_list: @entity1744 :: ('MESH:D043183', 'Disease') :: ['small bowel obstruction']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']


abstract: @entity66 is caused by the tapeworm @entity12047 and it is an endemic @entity4801 disease of the Mediterranean countries. Although the liver is the most involved organ by this disease, @entity8434 can be found anywhere in the @entity1 body. Rare forms of location may pose diagnostic and therapeutic dilemmas. Herein we report our experience with unusual located hydatid disease diagnosed and treated at our center the last 33 years. A total of 233 @entity1 were treated for @entity8434 (91 males: 39% and 142 females: 61%) between 1980 and 2013 at our center. 18 of them (7, 8%) with uncommon located hydatid disease, were analyzed retrospectively. 18 @entity1 (8 males and 10 females) were presented with unusual location of hydatid disease in our series. Two of them had only extrahepatic cysts (0, 9%). A total of 64 hydatid cysts with unusual location were analyzed. The most prevalent extrahepatic sites were peritoneal cavity and spleen. Total cystectomy with or without tube drainage or omentopexy was performed for hydatid cysts of the peritoneal cavity in our series. Splenectomy was performed in all cases of @entity8434 . The mean time of post operative stay was 16, 3 days (range 7-35 days), morbidity 11% and mortality 5, 4%. Although @entity8434 is found most often in the liver and lungs, it seems that any organ can be involved by this zoonotic disease. The operating surgeon must always consider the possibility of unusual location of @entity45 when dealing with @entity1 with @entity3928 in endemic areas, because any misinterpretation may result in unfavorable outcomes.

title: Unusual locations of hydatid disease: a 33  year's experience analysis on 233 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Hydatid disease']

entities_list: @entity3928 :: ('MESH:C536030', 'Disease') :: ['cystic mass']

entities_list: @entity8434 :: ('MESH:D004443', 'Disease') :: ['splenic hydatidosis', 'echinococcosis', 'hydatidosis']

entities_list: @entity12047 :: ('6210', 'Species') :: ['Echinococcus granulosus']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['echinococcal cyst']

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: To investigate the efficacy and safety of adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver in partial hepatectomy for @entity157 . MATERIALS AND METHODS: This is a retrospective study on data that were prospectively collected and entered into a computer database. A total of 36 @entity1 who underwent partial hepatectomy for @entity397 by adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver at a tertiary care university hospital were compared with a historical case-matched control group of 36 @entity1 who received intermittent Pringle maneuver only. RESULTS: The @entity1 characteristics were comparable for the 2 groups of @entity1 . The mean hepatic artery occlusion time was 58  min (range 36-98  min). Intraoperative @entity190 and blood transfusion rate in the study group were significantly lower than the control group (P  <  .001 and P  =  .004, respectively). There were no significant differences in the postoperative serum @entity492 transaminase and total @entity648 levels (P  =  .087, P  =  .135, respectively), and in the postoperative hospital stay and surgical complications according to Clavien's classification between the two groups (P  =  0.213, P  =  1.000, respectively). The disease-free survival rates in the study group was significantly better than the control group (P  =  .023). Overall, @entity157 @entity1 with @entity397 had poor prognosis. CONCLUSIONS: The addition of continuous occlusion of hepatic artery proper to intermittent Pringle maneuver significantly reduced intraoperative @entity190 for partial hepatectomy in @entity1 with @entity397 when compared with intermittent Pringle maneuver alone. The procedure was found to be safe even for @entity1 with @entity1575 .

title: Continuous occlusion of hepatic artery proper for prevention of XXXX in partial hepatectomy for @entity157 : a case-matched comparative study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['rupture', 'ruptured HCC']

entities_list: @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['ruptured hepatocellular carcinoma', 'HCC']

answer: @entity190 :: (MESH:D006473,Disease) :: ['blood loss']


abstract: BACKGROUND: To investigate the efficacy and safety of adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver in partial hepatectomy for @entity157 . MATERIALS AND METHODS: This is a retrospective study on data that were prospectively collected and entered into a computer database. A total of 36 @entity1 who underwent partial hepatectomy for @entity397 by adding continuous occlusion of hepatic artery proper to intermittent Pringle maneuver at a tertiary care university hospital were compared with a historical case-matched control group of 36 @entity1 who received intermittent Pringle maneuver only. RESULTS: The @entity1 characteristics were comparable for the 2 groups of @entity1 . The mean hepatic artery occlusion time was 58  min (range 36-98  min). Intraoperative @entity190 and blood transfusion rate in the study group were significantly lower than the control group (P  <  .001 and P  =  .004, respectively). There were no significant differences in the postoperative serum @entity492 transaminase and total @entity648 levels (P  =  .087, P  =  .135, respectively), and in the postoperative hospital stay and surgical complications according to Clavien's classification between the two groups (P  =  0.213, P  =  1.000, respectively). The disease-free survival rates in the study group was significantly better than the control group (P  =  .023). Overall, @entity157 @entity1 with @entity397 had poor prognosis. CONCLUSIONS: The addition of continuous occlusion of hepatic artery proper to intermittent Pringle maneuver significantly reduced intraoperative @entity190 for partial hepatectomy in @entity1 with @entity397 when compared with intermittent Pringle maneuver alone. The procedure was found to be safe even for @entity1 with @entity1575 .

title: Continuous occlusion of hepatic artery proper for prevention of @entity190 in partial hepatectomy for XXXX : a case-matched comparative study.

answer: @entity157 :: (MESH:D006528,Disease) :: ['ruptured hepatocellular carcinoma']


abstract: UNASSIGNED: Calcification is a rare phenomenon in high grade @entity11 (HGG). CT scans are sensitive to mineralization but used infrequently for @entity5 assessment in the MRI era. The presence of @entity730 can be overlooked on routine MRI. Calcification may reflect chronicity and natural changes in the @entity5 or its milieu over time and may be accelerated by certain treatments. Calcification may have clinical significance which could signal potential risk for @entity64 or @entity548 related to particular therapies; or it may be a positive prognostic factor for treatment response. The true incidence and relevance of @entity730 in HGG and relation to therapy is unclear. During treatment of HGG @entity1 with bevacizumab (BVZ) we observed significant @entity5 @entity730 on brain CT. We performed a retrospective review of HGG @entity1 treated with BVZ to quantitate the incidence of @entity730 in this group compared to those treated with cytotoxic therapy alone. Sixty-two @entity1 with progressive HGG were treated with BVZ and a cytotoxic agent. Among 19 @entity1 treated for 6+ months, 12 had a CT scan performed. We observed an unexpected phenomenon of @entity730 in the CT scans of several @entity1 . We were also able to comparatively quantitate the incidence of @entity730 in a control group of @entity463 (GB) @entity1 not exposed to BVZ therapy. The incidence of @entity730 in the general GB population is increased with longer survival. The phenomenon is increased with anti-angiogenic therapy for @entity1313 . Calcification may have significance as a predictor for treatment response.

title: Calcification in high grade XXXX treated with bevacizumab.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumors']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['primary glioblastoma']

answer: @entity11 :: (MESH:D005910,Disease) :: ['gliomas']


abstract: BACKGROUND: @entity1956 immune globulin (HBIg) in combination with a nucleos(t)ide analog is the mainstay of prophylactic regimen to prevent recurrence of @entity1956 following orthotopic liver transplantation (OLT). HBIg therapy is costly and inconvenient for the @entity1 . There is a growing experience converting HBIg/nucleos(t)ide to combination @entity4334 / @entity8742 analogs from. METHODS: Twenty-six @entity1 that underwent OLT between March 2001 and July 2011 who had received at least 12  months of HBIg and single nucleos(t)ide were enrolled. HBsAg and @entity97 DNA were undetectable, and anti-HBs were detectable at the time of switch. @entity97 DNA and @entity23109 were measured every 3  months following discontinuation of HBIg and addition of nucleos(t)ide. RESULTS: @entity1 included 23 Asians/3 Caucasian, 21 males/5 females. Mean time of conversion from HBIg/nucleos(t)ide to @entity8742 / @entity4334 combination was 77.5 (range 11-132) months after OLT. Mean duration of follow-up after conversion was 31.9 (range 14-70) months. All @entity1 had undetectable @entity97 DNA, and 24 @entity1 remained HBsAg negative during follow-up. Two @entity1 recurred 7 and 9  months later, respectively, with detectable HBsAg. Both @entity1 continued to have undetectable @entity97 DNA and normal ALT. HBsAg was neutralized by reinfusion of HBIg. CONCLUSION: @entity8742 / @entity4334 combination is an effective alternative to HBIg/nucleos(t)ide to prevent recurrence of @entity1956 after OLT.

title: @entity8742 - XXXX Analog Combination Therapy Is Effective in Preventing Recurrent @entity1956 After Liver Transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B', 'Hepatitis B']

entities_list: @entity8742 :: ('D009705', 'Chemical') :: ['nucleoside', 'Nucleoside']

answer: @entity4334 :: (D009711,Chemical) :: ['Nucleotide']


abstract: BACKGROUND: @entity1956 immune globulin (HBIg) in combination with a nucleos(t)ide analog is the mainstay of prophylactic regimen to prevent recurrence of @entity1956 following orthotopic liver transplantation (OLT). HBIg therapy is costly and inconvenient for the @entity1 . There is a growing experience converting HBIg/nucleos(t)ide to combination @entity4334 / @entity8742 analogs from. METHODS: Twenty-six @entity1 that underwent OLT between March 2001 and July 2011 who had received at least 12  months of HBIg and single nucleos(t)ide were enrolled. HBsAg and @entity97 DNA were undetectable, and anti-HBs were detectable at the time of switch. @entity97 DNA and @entity23109 were measured every 3  months following discontinuation of HBIg and addition of nucleos(t)ide. RESULTS: @entity1 included 23 Asians/3 Caucasian, 21 males/5 females. Mean time of conversion from HBIg/nucleos(t)ide to @entity8742 / @entity4334 combination was 77.5 (range 11-132) months after OLT. Mean duration of follow-up after conversion was 31.9 (range 14-70) months. All @entity1 had undetectable @entity97 DNA, and 24 @entity1 remained HBsAg negative during follow-up. Two @entity1 recurred 7 and 9  months later, respectively, with detectable HBsAg. Both @entity1 continued to have undetectable @entity97 DNA and normal ALT. HBsAg was neutralized by reinfusion of HBIg. CONCLUSION: @entity8742 / @entity4334 combination is an effective alternative to HBIg/nucleos(t)ide to prevent recurrence of @entity1956 after OLT.

title: XXXX - @entity4334 Analog Combination Therapy Is Effective in Preventing Recurrent @entity1956 After Liver Transplantation.

answer: @entity8742 :: (D009705,Chemical) :: ['Nucleoside']


abstract: BACKGROUND: @entity1956 immune globulin (HBIg) in combination with a nucleos(t)ide analog is the mainstay of prophylactic regimen to prevent recurrence of @entity1956 following orthotopic liver transplantation (OLT). HBIg therapy is costly and inconvenient for the @entity1 . There is a growing experience converting HBIg/nucleos(t)ide to combination @entity4334 / @entity8742 analogs from. METHODS: Twenty-six @entity1 that underwent OLT between March 2001 and July 2011 who had received at least 12  months of HBIg and single nucleos(t)ide were enrolled. HBsAg and @entity97 DNA were undetectable, and anti-HBs were detectable at the time of switch. @entity97 DNA and @entity23109 were measured every 3  months following discontinuation of HBIg and addition of nucleos(t)ide. RESULTS: @entity1 included 23 Asians/3 Caucasian, 21 males/5 females. Mean time of conversion from HBIg/nucleos(t)ide to @entity8742 / @entity4334 combination was 77.5 (range 11-132) months after OLT. Mean duration of follow-up after conversion was 31.9 (range 14-70) months. All @entity1 had undetectable @entity97 DNA, and 24 @entity1 remained HBsAg negative during follow-up. Two @entity1 recurred 7 and 9  months later, respectively, with detectable HBsAg. Both @entity1 continued to have undetectable @entity97 DNA and normal ALT. HBsAg was neutralized by reinfusion of HBIg. CONCLUSION: @entity8742 / @entity4334 combination is an effective alternative to HBIg/nucleos(t)ide to prevent recurrence of @entity1956 after OLT.

title: @entity8742 - @entity4334 Analog Combination Therapy Is Effective in Preventing Recurrent XXXX After Liver Transplantation.

answer: @entity1956 :: (MESH:D006509,Disease) :: ['Hepatitis B']


abstract: PURPOSE: To identify and highlight the variable causes of @entity3518 . METHOD: Literature review. RESULTS: Camptocormia ( @entity3518 ) is an acquired postural disease characterised by forward flexion of the thoraco-lumbar spine. Camptocormia leads to lumbar kyphosis and increases during walking or standing and completely disappears in supine position. Camptocormia is multicausal due to central or @entity1897 , @entity3762 or due to some rare conditions. Camptocormia is most frequently associated with @entity191 . Other causes include @entity3519 , @entity9576 , @entity195 , @entity121 , @entity4681 , @entity1737 or chronic inflammatory demyelinating @entity305 . Rare causes include adverse reactions of drugs, disc @entity3976 , @entity625 , @entity1566 , @entity74 , or @entity146 disease (more rarely than previously thought). Camptocormia is diagnosed upon clinical investigations, imaging of the cerebrum or spine, electromyography or muscle biopsy. Treatment is limited on supportive conservative measures, to withdrawal of causative drugs, electroconvulsive therapy, surgical correction or deep brain stimulation and effective only in single @entity1 . CONCLUSIONS: Camptocormia is organic in the vast majority of the cases due to @entity16 , or rarely drugs, @entity130 , @entity854 or @entity3762 .

title: Causes of XXXX .

entities_list: @entity3976 :: ('MESH:D004677', 'Disease') :: ['herniation']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disease']

entities_list: @entity1737 :: ('MESH:D009157', 'Disease') :: ['myasthenia']

entities_list: @entity305 :: ('MESH:D011115', 'Disease') :: ['polyneuropathy']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]

entities_list: @entity9576 :: ('MESH:D019578', 'Disease') :: ['multisystem atrophy']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral nervous system disease']

entities_list: @entity3518 :: ('MESH:C537968', 'Disease') :: ['camptocormia', 'bent spine syndrome']

entities_list: @entity4681 :: ('MESH:D016472', 'Disease') :: ['motor neuron disease']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['orthopedic abnormalities']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['paraneoplastic disorder']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal trauma']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"]

entities_list: @entity3762 :: ('MESH:C562694', 'Disease') :: ['idiopathic']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy']

answer: @entity3518 :: (MESH:C537968,Disease) :: ['camptocormia']


abstract: By regulating the timing of cellular processes, the circadian clock provides a way to adapt physiology and behaviour to the geophysical time. In mammals, a light-entrainable master clock located in the @entity10789 ( @entity10789 ) controls peripheral clocks that are present in virtually every body cell. Defective circadian timing is associated with several pathologies such as @entity5 and @entity209 . To better understand the circadian regulation of cellular processes, we developed a bioinformatics pipeline encompassing the analysis of high-throughput data sets and the exploitation of published knowledge by text-mining. We identified 118 novel potential clock-regulated genes and integrated them into an existing high-quality circadian network, generating the to-date most comprehensive network of circadian regulated genes (NCRG). To validate particular elements in our network, we assessed publicly available ChIP-seq data for @entity8713 , REV-ERBa/b and @entity19829 /y proteins and found strong evidence for circadian regulation of @entity11049 , @entity18962 , Dhx6, @entity21121 and @entity72061 all of which are involved in the regulation of tumourigenesis. Furthermore, we identified @entity4049 and @entity25933 , as targets of RORy and REV-ERBa, b, respectively. Most interestingly, these genes were also reported to be involved in miRNA regulation; in particular, @entity4049 regulates several miRNAs, all involved in @entity5 . Thus, @entity4049 represents a novel potential link via which the circadian clock, and specifically RORy, regulates the expression of miRNAs, with particular consequences in @entity0 progression. Our findings bring us one step forward towards a mechanistic understanding of @entity1 circadian regulation, and provide further evidence of the influence of circadian deregulation in @entity5 .

title: Assembly of a comprehensive regulatory network for the XXXX circadian clock: a bioinformatics approach.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity10789 :: ('MESH:D002527', 'Disease') :: ['suprachiasmatic nucleus', 'SCN']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer aggressiveness', 'cancer']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic and sleep disorders']

answer: @entity1 :: (9606,Species) :: ['mammalian']


abstract: AIMS: We investigated the interaction between magnetic @entity505 nanotubes (CNTs) and mesenchymal stem cells (MSCs), and their ability to guide these intravenously injected cells in living @entity35 by using an external magnetic field. MATERIALS _ METHODS: Multiwalled CNTs were used to treat MSCs derived from @entity35 bone marrow. @entity137 induced by nanotubes was studied using the WST-1 proliferation and Hoechest 33258 apoptosis assays. The effects of nanotubes on MSCs were evaluated by monitoring the effects on cellular growth rates, immunophenotyping and differentiation, and on the arrangement of cytoskeletal actin. MSCs loaded with nanotubes were injected in vivo in the portal vein of @entity35 driving their localization in the liver by magnetic field. An histological analysis was performed on the liver, lungs and kidneys of all animals. RESULTS: CNTs did not affect cell viability and their ability to differentiate in osteocytes and adipocytes. Both the CNTs and the magnetic field did not alter the cell growth rate, phenotype and cytoskeletal conformation. CNTs, when exposed to magnetic fields, are able to shepherd MSCs towards the magnetic source in vitro. Moreover, the application of a magnetic field alters the biodistribution of CNT-labelled MSCs after intravenous injection into @entity35 , increasing the accumulation of cells into the target organ (liver). CONCLUSION: Multiwalled CNTs hold the potential for use as nanodevices to improve therapeutic protocols for transplantation and homing of stem cells in vivo. This could pave the way for the development of new strategies for the manipulation/guidance of MSCs in regenerative medicine and cell transplantation.

title: Magnetic XXXX nanotubes: a new tool for shepherding mesenchymal stem cells by magnetic fields.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['Cytotoxicity']

answer: @entity505 :: (MESH:D002244,Chemical) :: ['carbon']


abstract: UNASSIGNED: Power ultrasound reduces the traditional @entity4336 steeping time from 18 to 1.5 h during tortilla chips dough (masa) processing. This study sought to examine consumer (n = 99) acceptability and quality of tortilla chips made from the masa by traditional compared with ultrasonic methods. Overall appearance, flavor, and texture acceptability scores were evaluated using a 9-point hedonic scale. The baked chips (process intermediate) before and after frying (finished product) were analyzed using a texture analyzer and machine vision. The texture values were determined using the 3-point bend test using breaking force gradient (BFG), peak breaking force (PBF), and breaking distance (BD). The fracturing properties determined by the crisp @entity174 support rig using @entity174 force gradient (FFG), peak @entity174 force (PFF), and @entity174 ( @entity174 ). The machine vision evaluated the total surface area, lightness (L), color difference (  E), Hue (  h), and @entity2195 (C*). The results were evaluated by analysis of variance and means were separated using Tukey's test. Machine vision values of L,   h, were higher (P < 0.05) and   E was lower (P < 0.05) for fried and L,   h were significantly (P < 0.05) higher for baked chips produced from ultra-sonication as compare to traditional. Baked chips texture for ultra-sonication was significantly higher (P < 0.05) on BFG, BPD, PFF, and @entity174 . Fried tortilla chips texture were higher significantly (P < 0.05) in BFG and PFF for ultra-sonication than traditional processing. However, the instrumental differences were not detected in sensory analysis, concluding possibility of power ultrasound as potential tortilla chips processing aid.

title: Sensory and Quality Evaluation of Traditional Compared with Power Ultrasound Processed XXXX (Zea Mays) Tortilla Chips.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture', 'fracture distance', 'FD']

answer: @entity4336 :: (381124,Species) :: ['Corn']


abstract: PURPOSE: Rolapitant is a novel, long-acting @entity4757 ( @entity9766 antagonist. This study evaluated the safety and efficacy of four different doses of rolapitant for prevention of chemotherapy-induced @entity1209 (CINV) due to highly emetogenic chemotherapy (HEC). METHODS: This randomized, double-blind, active-controlled, global study was conducted in @entity1 receiving @entity900 -based chemotherapy >= 70  mg/m(2). @entity1 received a 9, 22.5, 90, or 180  mg oral dose of rolapitant or placebo with ondansetron and @entity619 on day 1 of chemotherapy. The primary end point was complete response (CR; no emesis and no use of rescue medication) in the overall (0 to 120  h) phase of cycle 1. Other assessments were CR in delayed (24-120  h) and acute (0-24  h) phases, no emesis, no significant @entity390 , and no @entity390 . RESULTS: Four hundred fifty-four @entity1 were randomized. All doses of rolapitant improved CR with the greatest benefit observed with rolapitant 180  mg vs. active control in the overall phase (62.5 and 46.7  %, p   =   0.032) and in the acute (87.6 vs. 66.7  %, p   =   0.001) and delayed (63.6 vs. 48.9  %, p   =   0.045) phases. Rates for no emesis and no significant @entity390 were significantly (p   <   0.05) higher with rolapitant 180  mg vs. active control in the overall, acute, and delayed phases. Treatment-related adverse events were largely considered related to the chemotherapy and included @entity1142 , @entity10 , @entity1295 , and @entity1296 which were mostly mild or moderate and were similar across treatment groups. CONCLUSION: All doses of rolapitant were well tolerated and showed greater CR rates than active control. @entity17939 180  mg demonstrated significant clinical efficacy for preventing CINV in the overall, delayed, and acute phases for @entity1 receiving HEC.

title: Study of rolapitant, a novel, long-acting, @entity9766 antagonist, for the prevention of chemotherapy-induced XXXX (CINV) due to highly emetogenic chemotherapy (HEC).

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity17939 :: ('MESH:C578834', 'Chemical') :: ['Rolapitant']

entities_list: @entity1296 :: ('MESH:D004244', 'Disease') :: ['dizziness']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea and vomiting']

answer: @entity1209 :: (MESH:D020250,Disease) :: ['nausea and vomiting']


abstract: PURPOSE: Rolapitant is a novel, long-acting @entity4757 ( @entity9766 antagonist. This study evaluated the safety and efficacy of four different doses of rolapitant for prevention of chemotherapy-induced @entity1209 (CINV) due to highly emetogenic chemotherapy (HEC). METHODS: This randomized, double-blind, active-controlled, global study was conducted in @entity1 receiving @entity900 -based chemotherapy >= 70  mg/m(2). @entity1 received a 9, 22.5, 90, or 180  mg oral dose of rolapitant or placebo with ondansetron and @entity619 on day 1 of chemotherapy. The primary end point was complete response (CR; no emesis and no use of rescue medication) in the overall (0 to 120  h) phase of cycle 1. Other assessments were CR in delayed (24-120  h) and acute (0-24  h) phases, no emesis, no significant @entity390 , and no @entity390 . RESULTS: Four hundred fifty-four @entity1 were randomized. All doses of rolapitant improved CR with the greatest benefit observed with rolapitant 180  mg vs. active control in the overall phase (62.5 and 46.7  %, p   =   0.032) and in the acute (87.6 vs. 66.7  %, p   =   0.001) and delayed (63.6 vs. 48.9  %, p   =   0.045) phases. Rates for no emesis and no significant @entity390 were significantly (p   <   0.05) higher with rolapitant 180  mg vs. active control in the overall, acute, and delayed phases. Treatment-related adverse events were largely considered related to the chemotherapy and included @entity1142 , @entity10 , @entity1295 , and @entity1296 which were mostly mild or moderate and were similar across treatment groups. CONCLUSION: All doses of rolapitant were well tolerated and showed greater CR rates than active control. @entity17939 180  mg demonstrated significant clinical efficacy for preventing CINV in the overall, delayed, and acute phases for @entity1 receiving HEC.

title: Study of rolapitant, a novel, long-acting, XXXX antagonist, for the prevention of chemotherapy-induced @entity1209 (CINV) due to highly emetogenic chemotherapy (HEC).

answer: @entity9766 :: (6869,Gene) :: ['NK-1 receptor']


abstract: OBJECTIVES: To assess the feasibility of a novel diagnostic algorithm targeting @entity1 with risk factors for @entity409 in a community setting. DESIGN: Prospective cross-sectional study. SETTING: Two primary care practices (adult @entity1 population 10   479) in Nottingham, UK. @entity1 : Adult @entity1 (aged 18   years or over) fulfilling one or more selected risk factors for developing @entity409 : (1) hazardous @entity285 use, (2) type 2 @entity6 or (3) persistently elevated @entity3929 aminotransferase (ALT) liver function enzyme with negative serology. INTERVENTIONS: A serial biomarker algorithm, using a simple blood-based marker ( @entity5906 aminotransferase:ALT ratio for hazardous @entity285 users, BARD score for other risk groups) and subsequently liver stiffness measurement using transient elastography (TE). MAIN OUTCOME MEASURES: Diagnosis of clinically significant @entity409 (defined as liver stiffness >= 8   kPa); definitive diagnosis of @entity1575 . RESULTS: We identified 920 @entity1 with the defined risk factors of whom 504 @entity1 agreed to undergo investigation. A normal blood biomarker was found in 62 @entity1 (12.3%) who required no further investigation. Subsequently, 378 @entity1 agreed to undergo TE, of whom 98 (26.8% of valid scans) had elevated liver stiffness. Importantly, 71/98 (72.4%) @entity1 with elevated liver stiffness had normal liver enzymes and would be missed by traditional investigation algorithms. We identified 11 new @entity1 with definite @entity82 , representing a 140% increase in the number of diagnosed cases in this population. CONCLUSIONS: A non-invasive liver investigation algorithm based in a community setting is feasible to implement. Targeting risk factors using a non-invasive biomarker approach identified a substantial number of @entity1 with previously undetected @entity82 . TRIAL REGISTRATION NUMBER: The diagnostic algorithm utilised for this study can be found on clinicaltrials.gov (NCT02037867), and is part of a continuing longitudinal cohort study.

title: Direct targeting of risk factors significantly increases the detection of XXXX in primary care: a cross-sectional diagnostic study utilising transient elastography.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['chronic liver disease', 'liver disease']

entities_list: @entity1575 :: ('MESH:D008103', 'Disease') :: ['liver cirrhosis']

answer: @entity1575 :: (MESH:D008103,Disease) :: ['liver cirrhosis']


abstract: AIM: To investigate the dynamic changes and functions of @entity3663 (UT) in pulmonary arteries of @entity35 chronically exposed to @entity519 - @entity2944 . METHODS: In @entity35 with @entity519 - @entity2944 at 1, 2 and 4 weeks @entity3663 receptor binding of pulmonary arteries sarcolemma was determined by radioligand assay. @entity3663 mRNA and UTmRNA in various grades of pulmonary arterioles were measured by in situ hybridization. RESULTS: (1) Mean pulmonary pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV + S) of 1-week group were higher than those of normal control (NC) group by 26.2% and 21.6% (P < 0.01), respectively, and 2-week group higher than 1-week group by 22.5% and 14.1% (respectively, P < 0.01). However, no significant changes were found between 4-week and 2-week group. (2) U Il receptor (Bmax) of 1-week group was higher than NC group by 38.8%, 2-week group higher than 1-week group by 23.2%, and 4-week group increased 7.3% compared with 2-week group (respectively, P < 0.01). The UT changes were time-dependent, while the affinity to @entity3663 (Kd) was no different among each group. (3) @entity3663 mRNA in each grade of pulmonary arterioles of 2-week group and 4-week group were higher than NC group (respectively, P < 0.01), and those of 2-week group were higher than 1-week group by 5.9% (P > 0.05), 16.4% and 9.1% (respectively, P < 0.01), while no differences existed between 2-week group and 4-week group. (4) UT mRNA in each grade of pulmonary arterioles of all @entity519 - @entity2944 groups was higher than NC group (respectively, P < 0.01), and those of two abaxial grade vessels in 1-week group were the highest. No differences existed between 2-week group and 4-week group. (5) The pulmonary vessels remodeling were time-dependently aggravated by @entity519 - @entity2944 . CONCLUSION: The dynamic changes of UT in pulmonary arterioles might have important contribution to the development of @entity120 and @entity358 remodeling induced by chronic @entity519 - @entity2944 in @entity35 .

title: [Dynamic changes of urotensin II receptor in pulmonary artery and arterioles of @entity35 chronically exposed to XXXX - @entity2944 ].

entities_list: @entity2944 :: ('MESH:D006935', 'Disease') :: ['hypercapnia']

entities_list: @entity120 :: ('MESH:D006976', 'Disease') :: ['pulmonary hypertension']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary arteriole']

entities_list: @entity3663 :: ('29180(Tax:10116)', 'Gene') :: ['U II', 'urotensin II (U lI) receptor', 'UII']

answer: @entity519 :: (MESH:D000860,Disease) :: ['hypoxia']


abstract: AIM: To investigate the dynamic changes and functions of @entity3663 (UT) in pulmonary arteries of @entity35 chronically exposed to @entity519 - @entity2944 . METHODS: In @entity35 with @entity519 - @entity2944 at 1, 2 and 4 weeks @entity3663 receptor binding of pulmonary arteries sarcolemma was determined by radioligand assay. @entity3663 mRNA and UTmRNA in various grades of pulmonary arterioles were measured by in situ hybridization. RESULTS: (1) Mean pulmonary pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV + S) of 1-week group were higher than those of normal control (NC) group by 26.2% and 21.6% (P < 0.01), respectively, and 2-week group higher than 1-week group by 22.5% and 14.1% (respectively, P < 0.01). However, no significant changes were found between 4-week and 2-week group. (2) U Il receptor (Bmax) of 1-week group was higher than NC group by 38.8%, 2-week group higher than 1-week group by 23.2%, and 4-week group increased 7.3% compared with 2-week group (respectively, P < 0.01). The UT changes were time-dependent, while the affinity to @entity3663 (Kd) was no different among each group. (3) @entity3663 mRNA in each grade of pulmonary arterioles of 2-week group and 4-week group were higher than NC group (respectively, P < 0.01), and those of 2-week group were higher than 1-week group by 5.9% (P > 0.05), 16.4% and 9.1% (respectively, P < 0.01), while no differences existed between 2-week group and 4-week group. (4) UT mRNA in each grade of pulmonary arterioles of all @entity519 - @entity2944 groups was higher than NC group (respectively, P < 0.01), and those of two abaxial grade vessels in 1-week group were the highest. No differences existed between 2-week group and 4-week group. (5) The pulmonary vessels remodeling were time-dependently aggravated by @entity519 - @entity2944 . CONCLUSION: The dynamic changes of UT in pulmonary arterioles might have important contribution to the development of @entity120 and @entity358 remodeling induced by chronic @entity519 - @entity2944 in @entity35 .

title: [Dynamic changes of urotensin II receptor in pulmonary artery and arterioles of @entity35 chronically exposed to @entity519 - XXXX ].

answer: @entity2944 :: (MESH:D006935,Disease) :: ['hypercapnia']


abstract: AIM: To investigate the dynamic changes and functions of @entity3663 (UT) in pulmonary arteries of @entity35 chronically exposed to @entity519 - @entity2944 . METHODS: In @entity35 with @entity519 - @entity2944 at 1, 2 and 4 weeks @entity3663 receptor binding of pulmonary arteries sarcolemma was determined by radioligand assay. @entity3663 mRNA and UTmRNA in various grades of pulmonary arterioles were measured by in situ hybridization. RESULTS: (1) Mean pulmonary pressure (mPAP) and weight ratio of right ventricle to left ventricle and septum (RV/LV + S) of 1-week group were higher than those of normal control (NC) group by 26.2% and 21.6% (P < 0.01), respectively, and 2-week group higher than 1-week group by 22.5% and 14.1% (respectively, P < 0.01). However, no significant changes were found between 4-week and 2-week group. (2) U Il receptor (Bmax) of 1-week group was higher than NC group by 38.8%, 2-week group higher than 1-week group by 23.2%, and 4-week group increased 7.3% compared with 2-week group (respectively, P < 0.01). The UT changes were time-dependent, while the affinity to @entity3663 (Kd) was no different among each group. (3) @entity3663 mRNA in each grade of pulmonary arterioles of 2-week group and 4-week group were higher than NC group (respectively, P < 0.01), and those of 2-week group were higher than 1-week group by 5.9% (P > 0.05), 16.4% and 9.1% (respectively, P < 0.01), while no differences existed between 2-week group and 4-week group. (4) UT mRNA in each grade of pulmonary arterioles of all @entity519 - @entity2944 groups was higher than NC group (respectively, P < 0.01), and those of two abaxial grade vessels in 1-week group were the highest. No differences existed between 2-week group and 4-week group. (5) The pulmonary vessels remodeling were time-dependently aggravated by @entity519 - @entity2944 . CONCLUSION: The dynamic changes of UT in pulmonary arterioles might have important contribution to the development of @entity120 and @entity358 remodeling induced by chronic @entity519 - @entity2944 in @entity35 .

title: [Dynamic changes of urotensin II receptor in pulmonary artery and arterioles of XXXX chronically exposed to @entity519 - @entity2944 ].

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: BACKGROUND AND OBJECTIVE: @entity1 with @entity9826 , an abnormally short, thickened, or tight lingual frenulum, may have @entity5773 mobility and sequelae, such as speech and feeding difficulties and social concerns. We systematically reviewed literature on feeding, speech, and social outcomes of treatments for @entity1 and @entity1 with @entity9826 . METHODS: Medline, PsycINFO, Cumulative Index of Nursing and Allied Health Literature, and Embase were searched. Two reviewers independently assessed studies against predetermined inclusion/exclusion criteria. Two investigators independently extracted data on study populations, interventions, and outcomes and assessed study quality. RESULTS: Two randomized controlled trials, 2 cohort studies, and 11 case series assessed the effects of frenotomy on feeding, speech, and social outcomes. Bottle feeding and social concerns, such as ability to use the tongue to eat ice cream and clean the mouth, improved more in treatment groups in comparative studies. Supplementary bottle feedings decreased over time in case series. Two cohort studies reported improvement in articulation and intelligibility with treatment. Other benefits were unclear. One randomized controlled trial reported improved articulation after Z-frenuloplasty compared with horizontal-to-vertical frenuloplasty. Numerous noncomparative studies reported speech benefits posttreatment; however, studies primarily discussed modalities, with outcomes including safety or feasibility, rather than speech. We included English-language studies, and few studies addressed longer-term speech, social, or feeding outcomes; nonsurgical approaches, such as complementary and alternative medicine; and outcomes beyond infancy, when speech or social concerns may arise. CONCLUSIONS: Data are currently insufficient for assessing the effects of frenotomy on nonbreastfeeding outcomes that may be associated with @entity9826 .

title: Treatment of XXXX for Reasons Other Than Breastfeeding: A Systematic Review.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children', 'infants']

entities_list: @entity5773 :: ('MESH:D014060', 'Disease') :: ['restricted tongue']

entities_list: @entity9826 :: ('MESH:C562396', 'Disease') :: ['ankyloglossia']

answer: @entity9826 :: (MESH:C562396,Disease) :: ['Ankyloglossia']


abstract: INTRODUCTION AND AIM: Low Level Laser Therapy (LLLT) can facilitate wound healing stimulating a more rapid resolution and an earlier start for the proliferation phase. The purpose of this study is to evaluate the effects of LLLT on postoperative @entity158 and @entity4 following the removal of impacted lower third molars. MATERIALS AND METHODS: Fifty-nine @entity1 , who were to undergo surgical removal of their lower third molars, were studied. @entity1 were randomly allocated to one of three groups: 17 @entity1 LLLT + traditional drug treatment17 @entity1 traditional drug treatment as control group25 @entity1 treated with LLLT only on one side+traditional drug treatment. The laser we have used for this study is a diode laser, @entity7565 , which delivers both in the infrared band at the wavelength of 910 nanometers (pulsed and superpulsed source), and in the visible (continuous source) at the wavelength of 650 nanometers (red). LLLT was performed just after the intervention and approximately 12 hours after surgery delivering 240 J in 15 minutes with theoretical fluence values of 480 J/cm(2) and 31 J/cm(2) for every minute of irradiation. We considered and signed with a label constant landmarks on both sides of the face of each @entity1 ; measurements were taken: before the surgery, after the surgery right after the 1st laser treatment, after approximately 24 hours after the 2(nd) laser treatment. RESULTS: We collected all the values of the @entity4 measurements and the VAS reports and performed a statistical analysis by means One-way Analysis of Variance (ANOVA) test: for the evaluated values (X, Y, Z) an extremely significant difference was found with p values of 0.003 for Y at the first evaluation (pre-12 hours) and less than 0.001 for the other evaluations. A significant result was obtained for VAS recorded at hospital discharge (p<0.0001). CONCLUSIONS: This study demonstrates that LLLT is effective on postoperative @entity158 and @entity4 accelerating healing time and reducing @entity1 distress.

title: Efficacy of LLLT in swelling and XXXX control after the extraction of lower impacted third molars.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['oedema']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: UNASSIGNED: @entity784 ( @entity784 ) is a potentially devastating @entity5 . The pathogenesis of this @entity5 remains poorly elucidated. Previous studies focused on analysis of expression and function of known oncogenes and @entity5 suppressor genes. However, emerging reports highlight that it is also important to analyze the expression of genes that are ectopically expressed in @entity784 (e.g., embryonic stem cell genes (ESC), @entity5 ( @entity5 ) genes, etc.). Currently, it is not known whether ESC genes are expressed in @entity784 . In the current work, we analyze by RT-PCR the expression of 26 ESC genes, many of which are known to regulate pluripotency and promote @entity5 stem cell-like phenotype, in a historic cohort of 60 @entity1 from Boston and in a panel of 11 @entity1 -derived @entity784 cell lines and compare such expression to benign inflammatory dermatoses that often clinically mimic @entity784 . Our findings document that many critical ESC genes including @entity2440 , @entity4731 , @entity4729 ( @entity4729 ) and their upstream and downstream signaling members are expressed in @entity784 . Similarly, polycomb repressive complex 2 (PRC2) genes (i.e., @entity16719 , @entity16718 , and @entity38612 ) are also expressed in @entity784 lesional skin. Furthermore, select ESC genes ( @entity4729 , @entity16718 , @entity11260 , @entity72062 , @entity23740 , @entity24377 , @entity42364 ) are preferentially expressed in @entity784 samples when compared to benign skin biopsies. Our work suggests that ESC genes are ectopically expressed together with @entity5 genes, thymocyte development genes and B cell-specific genes and may be working in concert to promote tumorigenesis. Specifically, while ESC genes may be promoting @entity5 stem cell-like phenotype, @entity5 genes may be contributing to @entity2007 and @entity5555 by producing aberrant chromosomal translocations. Further analysis of ESC expression and function in this @entity5 will greatly enhance our fundamental understanding of @entity784 and will help us identify novel therapeutic targets.

title: Ectopic expression of embryonic stem cell and other developmental genes in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'patients']

entities_list: @entity2007 :: ('MESH:D000782', 'Disease') :: ['aneuploidy']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy', 'cancer testis', 'tumor', 'CT', 'cancer']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['Cutaneous T-cell lymphoma', 'CTCL']

entities_list: @entity5555 :: ('MESH:D042822', 'Disease') :: ['genomic instability']

answer: @entity784 :: (MESH:D016399,Disease) :: ['cutaneous T-cell lymphoma']


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Pereskia aculeata Miller (Cactaceae), known as Barbados gooseberry, are used in Brazilian traditional medicine as emollients and to treat @entity272 and @entity32 . This study investigated the topical anti-inflammatory activity of the @entity4315 fraction (HF) obtained from the @entity1042 extract of the leaves of this species in models of @entity1909 in @entity19 . MATERIAL AND METHODS: @entity19 ear @entity4 was induced by topical application of croton oil, @entity1426 , @entity2951 , @entity40065 and @entity3971 ; and by subcutaneous injection of @entity112 . Ear biopsies were obtained to determine the levels of @entity635 , @entity777 and @entity637 cytokines by ELISA assay. Histopathological analysis was also performed to evaluate the HF activity in croton oil multiple application test. In addition, acute dermal irritation/corrosion test in @entity35 was accomplished. HF chemical characterization was performed by GC-MS analysis. RESULTS: HF intensively reduced the inflammatory process induced by all irritant agents used, except for @entity1426 . This activity is related, at least in part, to the reduction of @entity777 and @entity637 cytokines levels. Moreover, when the glucocorticoid receptor antagonist @entity3927 was used, HF failed to respond to the croton oil application.The results strongly suggested a glucocorticoid-like effect, which was reinforced by the presence of considerable amounts of @entity5068 compounds identified in HF. The acute dermal irritaton/corrosion test showed no signs of @entity137 . CONCLUSIONS: This study showed that the acute and chronic anti-inflammatory activity of P. aculeata leaves is very promising, and corroborates to better understand their ethnopharmacological applications.

title: Pereskia aculeata Miller leaves present in vivo topical anti-inflammatory activity in models of XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin']

entities_list: @entity1042 :: ('MESH:D000432', 'Chemical') :: ['methanol']

entities_list: @entity1426 :: ('MESH:D016718', 'Chemical') :: ['arachidonic acid']

entities_list: @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']

entities_list: @entity40065 :: ('MESH:C015202', 'Chemical') :: ['ethyl-phenylpropiolate']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin wounds']

entities_list: @entity3927 :: ('MESH:D015735', 'Chemical') :: ['mifepristone']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['acute and chronic ear dermatitis']

answer: @entity1909 :: (MESH:D003872,Disease) :: ['acute and chronic dermatitis']


abstract: PURPOSE: @entity174 ( @entity174 ) have potentially catastrophic consequences due to frontal recess (FR) obstruction and proximity to the brain and orbit. Lack of follow-up and ability to predict which type of @entity174 predispose to complications has biased surgeons toward definitive interventions such as sinus obliteration and cranialization. These procedures carry inherent risk and may be unnecessary in a subset of @entity1 . This study seeks to better characterize spontaneous ventilation in subjects with FSFs, including those involving the FR. MATERIALS AND METHODS: Review of a prospectively maintained @entity130 database between 2009 and 2013 at a level 1 @entity130 center. @entity1 with @entity174 with follow-up imaging (>6weeks) available were included. The medical records and imaging were reviewed for evidence of spontaneous ventilation of the frontal sinus. RESULTS: Nineteen @entity1 @entity174 in the study period with mean imaging interval of 67.4weeks (range, 6-188.4weeks). Injury mechanisms included fall (32%), assault (31%), motor vehicle accident (17%), pedestrian-versus-automobile (12%), and gunshot wound (8%). 8/19 @entity1 (42%) sustained FSFs involving the FR and 7/8 (87.5%) spontaneously ventilated by time of interval imaging. The one @entity1 with persistent radiographic sinus opacification was associated with a naso orbital ethmoid and medial orbital blowout fracture. 6/19 @entity1 (32%) sustained @entity174 sparing the FR, and all spontaneously ventilated by the time of interval imaging. 5/19 @entity1 (26%) underwent surgical intervention. CONCLUSIONS: An expectant, sinus-preserving approach to acute FSFs involving the FR is safe and effective. Etiology of re-ventilation failure may be due to tissue obstruction, rather than the frontal recess fracture itself.

title: Spontaneous ventilation of the frontal sinus after XXXX involving the frontal recess.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'sustained frontal sinus fractures', 'Frontal sinus fractures', 'frontal sinus fractures', 'FSF']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: BACKGROUND AND AIM: A higher body mass index (BMI) appears to be reversely associated with mortality in dialysis @entity1 . Moreover, although @entity1 have better survival in @entity740 ( @entity740 ), this survival advantage is cancelled in dialysis. The association between BMI and mortality and the gender difference remain controversial in advanced @entity740 . METHODS: This study enrolled 3,320 @entity1 (1,938 @entity1 and 1,382 @entity1 ) from southern Taiwan who had @entity740 stages 3-5 with a BMI of 15.0-35.0 kg/m2. RESULTS: During a median 2.9-year follow-up, there were 328 (16.9%) all-cause mortality and 319 (16.5%) cardiovascular (CV) events and @entity204 in male @entity1 , 213 (15.4%) all-cause mortality and 224 (16.2%) CV events and @entity204 in female @entity1 . Compared with the reference BMI of 27.6-30.0 kg/m2 in an adjusted Cox model, lower-BMI groups in @entity1 , BMI 15.0-20.0 kg/m2 and 20.1-22.5 kg/m2, were associated with higher risks of all-cause mortality: hazard ratios (HRs) 3.19 (95% confidence interval [CI], 1.97-5.18) and 2.01 (95% CI, 1.29-3.14), respectively. Higher-BMI group in @entity1 , BMI 30.1-35.0 kg/m2, was associated with a higher risk of all-cause mortality: HR 1.72 (95% CI, 1.02-2.96). Likewise, lower- and higher-BMI groups in @entity1 were associated with a higher risk of CV events and @entity204 . In @entity1 , these associations between BMI and poor outcomes were not observed. CONCLUSIONS: In advanced @entity740 , there was a reverse J-shaped association between BMI and all-cause mortality, and a U-shaped association between BMI and CV outcomes in @entity1 . Neutral associations between BMI and poor outcomes were detected in @entity1 . Gender could modify the effect of BMI on mortality in @entity1 with @entity740 .

title: Body Mass Index, Mortality, and Gender Difference in Advanced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

answer: @entity740 :: (MESH:D051436,Disease) :: ['Chronic Kidney Disease']


abstract: The aim of this study was to investigate the anti-inflammatory effect of Guizhi Fuling capsule and its active complex (consistent of 15 active compounds) on @entity558 -induced RAW264. 7 cells. The effect of Guizhi Fuling capsule and its active complex on cell viability in RAW264. 7 cells were determined by @entity98 assay. The inhibitory effect of Guizhi Fuling capsule and active complex on the releasing of @entity635 , @entity637 and @entity1421 induced by @entity558 in RAW264. 7 cells was detected by ELISA assay. The expression of @entity635 and @entity8207 in Guizhi Fuling capsule or active complex treated RAW264. 7 cells was examined by Western blot assay. Guizhi Fuling capsule and active complex showed no significant effect on the cell viability in RAW264. 7 cells at doses range from 12.5 to 400 mg x L(-1). Compared with @entity558 treated group, Guizhi Fuling capsule and active complex dose dependently reduced the releasing of @entity635 , @entity637 and @entity1421 induced by @entity558 in RAW264. 7 cells. Moreover, the expression of @entity635 and @entity8207 was decreased after Guizhi Fuling capsule and active complex treatment, which might contribute to the inhibitory effect of Guizhi Fuling capsule in the releasing of @entity635 , @entity637 and @entity1421 . This study provided the evidence that Guizhi Fuling capsule and active complex remarkably inhibited the releasing of @entity635 , @entity637 and PGE2induced by @entity558 in RAW264. 7 cells by reducing the expression @entity635 and @entity8207 . This study provided an experimental basis of Guizhi Fuling capsule for the treatment of @entity32 and a theoretical basis for the development of effective compounds of Guizhi Fuling capsule.

title: [Study on anti- XXXX effect and involved mechanism of Guizhi Fuling capsule and its active complex].

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: The E2F/Pocket protein (Rb) pathway regulates cell growth, differentiation, and @entity204 by modulating gene expression. We previously examined this pathway in the myocardium via manipulation of the unique E2F repressor, @entity35826 , which is believed to repress gene activity independently of Rb. @entity19 with targeted expression of @entity35826 in postnatal myocardium developed @entity384 ( @entity384 ) without @entity851 . We assessed the mechanisms of the apparent failure of compensatory @entity851 as well as their response to the b-adrenergic agonist @entity3044 . As early as 2weeks, @entity35826 transgenic (Tg) @entity19 present with dilated thinner left ventricles and significantly reduced ejection fraction and fractional shortening which persists at 6weeks of age, but with no apparent increase in left ventricle weight: body weight (LVW:BW). @entity35826 -Tg @entity19 treated with @entity3044 (6.1mg/kg/day) show double the increase in LVW:BW than their Wt counterparts (32% vs 16%, p-value: 0.007). Western blot analysis revealed the activation of the adrenergic pathway in Tg heart tissue under basal conditions with ~2-fold increase in the level of b2-adrenergic receptors (p-value: 8.9E-05), protein kinase A catalytic subunit (PKA-C) (p-value: 0.0176), activated c-Src @entity4149 -protein kinase (p-value: 0.0002), @entity13436 ( @entity13436 ) (p-value: 0.0005), and induction of the anti-apoptotic protein @entity1379 (p-value 0. 0.00001). In contrast, a ~60% decrease in the cardiac growth regulator: @entity1994 (p-value 0.0001) and a ~four fold increase in @entity1919 dependent @entity37447 ( @entity37447 ), the negative regulator of PKA activity, were evident in the myocardium of @entity35826 -Tg @entity19 . The expression of @entity41716 was down-regulated by @entity35826 , but was restored by @entity3044 . Further, Rb expression was down-regulated in Tg @entity19 in response to @entity3044 implying a net activation of the E2F pathway. Thus the unique regulation of E2F activity by @entity35826 renders the myocardium hypersensitive to adrenergic stimulus resulting in robust @entity851 . These data reveal a novel interplay between the E2F pathway, b2-adrenergic/PKA/ @entity37447 , and @entity13436 /c-Src axis in fine tuning the pathological @entity851 response. @entity35826 deregulates @entity41716 such that pro- @entity851 and survival are enhanced via b2-adrenergic signaling however this response is outweighed by the induction of anti- @entity1184 signals so that left ventricle dilation proceeds without any increase in muscle mass.

title: Interplay between the E2F pathway and b-adrenergic signaling in the pathological XXXX response of myocardium.

entities_list: @entity851 :: ('MESH:D006130', 'Disease') :: ['hypertrophic growth']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['DCM', 'dilated cardiomyopathy']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophic']

entities_list: @entity1919 :: ('MESH:D000242', 'Chemical') :: ['cyclic AMP']

entities_list: @entity13436 :: ('26413(Tax:10090)', 'Gene') :: ['ERK2', 'extracellular receptor kinase 2', 'ERK']

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['isoproterenol']

answer: @entity1184 :: (MESH:D006984,Disease) :: ['hypertrophic']


abstract: BACKGROUND: @entity5 is the third most common @entity5 in @entity1 globally, and despite treatment, distant @entity3 and nodal recurrence will still develop in approximately 30% of @entity1 . The ability to predict which @entity1 are likely to experience distant relapse would allow clinicians to better tailor treatment. Previous studies have investigated the role of @entity1344 ( @entity1344 ) in @entity5 , which can promote @entity5 initiation and growth; a hallmark of @entity1 @entity5 . In this study, we sought to examine the published CIN70 gene signature in a cohort of @entity5 @entity1 treated at the Princess Margaret (PM) Cancer Centre and an independent cohort of The @entity5 (TCGA) @entity5 @entity1 , to determine if this @entity1344 signature associated with @entity1 outcome. METHODS: @entity5 samples were collected from 79 @entity1 , treated between 2000-2007 at the PM, prior to undergoing curative chemo-radiation. Total RNA was extracted from each @entity1 sample and analyzed using the GeneChip @entity1 Genome U133 Plus 2.0 array (Affymetrix). RESULTS: High CIN70 scores were significantly related to increased chromosomal alterations in TCGA @entity5 @entity1 , including a higher percentage of genome altered and a higher number of copy number alterations. In addition, this same CIN70 signature was shown to be predictive of para-aortic nodal relapse in the PM Cancer Centre cohort. CONCLUSIONS: These findings demonstrate that @entity1344 plays an important role in @entity5 , and is significantly associated with @entity1 outcome. For the first time, this CIN70 gene signature provided prognostic value for @entity1 with @entity5 .

title: XXXX as a prognostic marker in @entity5 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer Genome Atlas', 'cancer', 'cervical cancer', 'malignancies', 'Cervical cancer', 'tumour']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients', 'patient', 'Human']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity1344 :: ('MESH:D043171', 'Disease') :: ['chromosomal instability', 'CIN']

answer: @entity1344 :: (MESH:D043171,Disease) :: ['Chromosomal instability']


abstract: BACKGROUND: @entity5 is the third most common @entity5 in @entity1 globally, and despite treatment, distant @entity3 and nodal recurrence will still develop in approximately 30% of @entity1 . The ability to predict which @entity1 are likely to experience distant relapse would allow clinicians to better tailor treatment. Previous studies have investigated the role of @entity1344 ( @entity1344 ) in @entity5 , which can promote @entity5 initiation and growth; a hallmark of @entity1 @entity5 . In this study, we sought to examine the published CIN70 gene signature in a cohort of @entity5 @entity1 treated at the Princess Margaret (PM) Cancer Centre and an independent cohort of The @entity5 (TCGA) @entity5 @entity1 , to determine if this @entity1344 signature associated with @entity1 outcome. METHODS: @entity5 samples were collected from 79 @entity1 , treated between 2000-2007 at the PM, prior to undergoing curative chemo-radiation. Total RNA was extracted from each @entity1 sample and analyzed using the GeneChip @entity1 Genome U133 Plus 2.0 array (Affymetrix). RESULTS: High CIN70 scores were significantly related to increased chromosomal alterations in TCGA @entity5 @entity1 , including a higher percentage of genome altered and a higher number of copy number alterations. In addition, this same CIN70 signature was shown to be predictive of para-aortic nodal relapse in the PM Cancer Centre cohort. CONCLUSIONS: These findings demonstrate that @entity1344 plays an important role in @entity5 , and is significantly associated with @entity1 outcome. For the first time, this CIN70 gene signature provided prognostic value for @entity1 with @entity5 .

title: @entity1344 as a prognostic marker in XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']


abstract: SCOPE: Insulin resistance represents an independent risk factor for metabolic and @entity65 . Researchers have been interested in identifying active harmless compounds, as many insulin-sensitizing drugs have shown unwanted side-effects. It has been demonstrated that @entity4211 and one of their representative metabolites, @entity16074 ( @entity4901 ), ameliorate @entity4854 , and insulin sensitivity. This study investigated the mechanism of action of @entity4901 responsible for the @entity413 uptake upregulation. METHODS AND RESULTS: In @entity1 visceral adipocytes, @entity4901 stimulated @entity10175 ( @entity10175 ) @entity4149 phosphorylation (+40% with respect to untreated cells) and the downstream events, i.e. @entity7425 3-kinase binding to @entity10175 and Akt phosphorylation (+100%, +180%, respectively, with respect to untreated cells). The insulin-like activity of @entity4901 seemed to be mediated by @entity8277 since by inhibiting its autophosphorylation, the @entity4901 effects were completely abolished. Furthermore, @entity4901 was able to activate @entity860 -activated protein kinase, a @entity563 / @entity1889 kinase whose activation elicits insulin-sensitizing effects. CONCLUSION: This study showed that @entity4901 stimulates the insulin signaling pathway in @entity1 adipocytes increasing @entity2368 translocation and @entity413 uptake. Decreasing insulin resistance is a most desirable aim to be reached for an effective therapeutic/preventive action against @entity209 and @entity164 2 @entity6 . Identifying specific food/food components able to improve @entity413 metabolism can offer an attractive, novel, and economical strategy.

title: XXXX activates key components of insulin signaling pathway mimicking insulin activity.

entities_list: @entity10175 :: ('3667', 'Gene') :: ['insulin receptor substrate-1', 'IRS-1']

entities_list: @entity563 :: ('CHEBI:17822', 'Chemical') :: ['serine']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity7425 :: ('CHEBI:18179', 'Chemical') :: ['phosphoinositide']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity8277 :: ('3643', 'Gene') :: ['insulin receptor']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular diseases']

entities_list: @entity4211 :: ('MESH:D000872', 'Chemical') :: ['anthocyanins']

entities_list: @entity860 :: ('MESH:D000249', 'Chemical') :: ['adenosine monophosphate']

entities_list: @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity16074 :: ('MESH:C009091', 'Chemical') :: ['protocatechuic acid']

answer: @entity16074 :: (MESH:C009091,Chemical) :: ['Protocatechuic acid']


abstract: Breath analysis is commonly understood to target gaseous or volatile organic compounds (VOCs) for the characterization of different pathologies. Targeted analysis is most effective if a working hypothesis can be based on a plethora of data. The recently published volatilome builds an optimal basis for organizing powerful target sets. However, the origin and pathways of biosynthesis of many VOCs are not known, which complicates the formulation of useful hypotheses. To find the missing link between VOCs and their origin, it is necessary to analyze their precursor fluids themselves. In order to provide condensation nuclei for the generation of future hypotheses, we provide the compositional space over 23 samples of the unperturbed @entity1 exhaled breath condensate (EBC) metabolome. We propose a way to connect the compositional spaces of both VOCs and EBC so as to gain insight into the most probable form of VOC precursors. In a way analogous to tandem @entity15 it is possible to create a mass difference network over compositional data by linking compositions with mass differences that are designed to mimic biochemical reactions. We propose to use mass difference enrichment analysis (MDEA) in order to mine probable relations between VOCs and their precursor fluids. We have found 2691 EBC compositions and linked them to 235 breath VOC compositions that correspond to 848 individual compounds. We found that VOCs are likely to be found as @entity12015 conjugates or as @entity3689 conjugates with @entity3264 or @entity2734 playing a major role. Furthermore, we found that @entity13961 mass differences may be more indicative for oxidative stress than oxygenation-hydrogenation sequences.

title: The compositional space of exhaled breath condensate and its link to the XXXX breath volatilome.

entities_list: @entity13961 :: ('CHEBI:35692', 'Chemical') :: ['dicarboxylic acid']

entities_list: @entity2734 :: ('CHEBI:17196', 'Chemical') :: ['Asparagine']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: AIM: To study the inflammatory microenvironment and expression of @entity157 ( @entity157 ) in @entity19 . METHODS: CBRH-7919 @entity157 cells were injected into the subcutaneous region of @entity19 . Beginning two weeks after the challenge, @entity5 growth was measured every week for six weeks. The stromal microenvironment and inflammatory cell infiltration was assessed by immunohistochemistry in paired @entity5 and adjacent peritumoral samples, and macrophage phenotype was assessed using double-stain immunohistochemistry incorporating expression of an intracellular enzyme. A chemokine PCR array, comprised of 98 genes, was used to screen differential gene expressions, which were validated by Western blotting. Additionally, expression of identified chemokines was knocked-down by RNA interference, and the effect on @entity5 growth was assessed. RESULTS: Inflammatory cell infiltrates are a key feature of adjacent peritumoral tissues with increased macrophage, neutrophil, and T cell (specifically helper and activated subsets) infiltration. Macrophages within adjacent peritumoral tissues express inducible @entity842 synthase, suggestive of a proinflammatory phenotype. Fifty-one genes were identified in @entity5 tissues during the progression period, including 50 that were overexpressed (including @entity15891 , @entity9701 and @entity72063 ) and three that were underexpressed ( @entity35028 , Ifg and @entity12835 ). RNA interference of @entity15891 in the CBRH-7919 cells decreased the growth of @entity5 in @entity19 and inhibited expression of @entity9701 , @entity72063 and @entity635 protein. CONCLUSION: These findings suggest that @entity15891 plays a critical role in @entity5 growth and may serve as a potential molecular target for use in @entity157 therapy.

title: Inflammatory microenvironment and expression of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'chemokines in hepatocellular carcinoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['chemokines in hepatocellular carcinoma']


abstract: PURPOSE: To investigate the @entity1314 ( @entity1314 ) diagnosed in @entity1 with @entity308 . MATERIAL AND METHODS: This study included a cross-sectional analysis, and was an extension of the Thai Study of @entity1316 (THAISAD) project. Eighty-five outpatients with @entity308 were interviewed using the Mini International Neuropsychiatric Inventory to assess for @entity308 , in accordance with the Diagnostic and Statistical Manual of @entity146 , Fourth Edition, Text Revision and using the Thai version of the Structured Clinical Interview for @entity1314 to assess for @entity1726 . RESULTS: Seventy-seven percent of the @entity1 had at least one @entity1726 , 40% had one @entity1726 and 60% had two or more @entity1314 (mixed cluster). The most common @entity1314 found were borderline @entity1726 (20%) and @entity3119 (10.6%), while the occurrence of avoidant @entity1726 was low when compared to the findings of previous, related studies. Among the mixed cluster, cluster A combined with cluster C was the common mix. Both @entity14256 and double @entity308 were found to have a higher proportion of @entity1314 than @entity308 (85.7% versus 76.1%). Dependent @entity1726 was found to be less common in this study than in previous studies, including those carried out in Asia. CONCLUSION: The prevalence of @entity1314 among those with @entity308 varied, and only borderline @entity1726 seems to be consistently high within and across cultures. Mixed cluster plays a prominent role in @entity308 , so more attention should be paid to @entity1 in this category.

title: Comorbid @entity1314 among @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depressive disorder', 'depression', 'major depressive disorder']

entities_list: @entity14256 :: ('MESH:D019263', 'Disease') :: ['dysthymic disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Mental Disorders']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['Affective Disorder']

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['PDs', 'personality disorders']

entities_list: @entity3119 :: ('MESH:D009771', 'Disease') :: ['obsessive-compulsive PD']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: PURPOSE: To investigate the @entity1314 ( @entity1314 ) diagnosed in @entity1 with @entity308 . MATERIAL AND METHODS: This study included a cross-sectional analysis, and was an extension of the Thai Study of @entity1316 (THAISAD) project. Eighty-five outpatients with @entity308 were interviewed using the Mini International Neuropsychiatric Inventory to assess for @entity308 , in accordance with the Diagnostic and Statistical Manual of @entity146 , Fourth Edition, Text Revision and using the Thai version of the Structured Clinical Interview for @entity1314 to assess for @entity1726 . RESULTS: Seventy-seven percent of the @entity1 had at least one @entity1726 , 40% had one @entity1726 and 60% had two or more @entity1314 (mixed cluster). The most common @entity1314 found were borderline @entity1726 (20%) and @entity3119 (10.6%), while the occurrence of avoidant @entity1726 was low when compared to the findings of previous, related studies. Among the mixed cluster, cluster A combined with cluster C was the common mix. Both @entity14256 and double @entity308 were found to have a higher proportion of @entity1314 than @entity308 (85.7% versus 76.1%). Dependent @entity1726 was found to be less common in this study than in previous studies, including those carried out in Asia. CONCLUSION: The prevalence of @entity1314 among those with @entity308 varied, and only borderline @entity1726 seems to be consistently high within and across cultures. Mixed cluster plays a prominent role in @entity308 , so more attention should be paid to @entity1 in this category.

title: Comorbid XXXX among @entity1 with @entity308 .

answer: @entity1314 :: (MESH:D010554,Disease) :: ['personality disorders']


abstract: PURPOSE: To investigate the @entity1314 ( @entity1314 ) diagnosed in @entity1 with @entity308 . MATERIAL AND METHODS: This study included a cross-sectional analysis, and was an extension of the Thai Study of @entity1316 (THAISAD) project. Eighty-five outpatients with @entity308 were interviewed using the Mini International Neuropsychiatric Inventory to assess for @entity308 , in accordance with the Diagnostic and Statistical Manual of @entity146 , Fourth Edition, Text Revision and using the Thai version of the Structured Clinical Interview for @entity1314 to assess for @entity1726 . RESULTS: Seventy-seven percent of the @entity1 had at least one @entity1726 , 40% had one @entity1726 and 60% had two or more @entity1314 (mixed cluster). The most common @entity1314 found were borderline @entity1726 (20%) and @entity3119 (10.6%), while the occurrence of avoidant @entity1726 was low when compared to the findings of previous, related studies. Among the mixed cluster, cluster A combined with cluster C was the common mix. Both @entity14256 and double @entity308 were found to have a higher proportion of @entity1314 than @entity308 (85.7% versus 76.1%). Dependent @entity1726 was found to be less common in this study than in previous studies, including those carried out in Asia. CONCLUSION: The prevalence of @entity1314 among those with @entity308 varied, and only borderline @entity1726 seems to be consistently high within and across cultures. Mixed cluster plays a prominent role in @entity308 , so more attention should be paid to @entity1 in this category.

title: Comorbid @entity1314 among XXXX with @entity308 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Oncogenic @entity1082 ) infection is the cause of nearly all @entity5 and a proportion of other anogenital and @entity5 . A bivalent vaccine containing @entity1799 and 18 and a quadrivalent vaccine containing HPV 6, 11, 16, and 18 antigens are in use in vaccination programmes around the world. In clinical trials, three vaccine doses provided 90-100% protection against cervical @entity5 related to @entity1799 and 18 in @entity1 aged 15-26 years who were not infected at vaccination. Partial cross-protection against other HPV types has been reported but its duration is unknown. The vaccines were also efficacious at the prevention of @entity1799 and 18 @entity281 at other anatomical sites in both sexes. Immunobridging studies allowed licensing of the vaccines for use starting at age 9 years for both sexes. Two-dose schedules elicit high antibody concentrations, leading to the recommendation of two-dose schedules for @entity1 aged 9-14 years. Pre-licensure and post-licensure studies have provided data supporting vaccine safety. In 2014, a nonavalent vaccine containing HPV 6, 11, 16, 18, 31, 33, 45, 52, and 58 antigens was licensed by the US Food and Drug Administration. HPV vaccination was first introduced in high-income countries owing to vaccine cost, logistic challenges, and competing health priorities. Since 2011, vaccine prices have lowered, allowing the introduction of the vaccine in some middle-income countries. Funding of the vaccine by the GAVI Alliance in 2012 led to demonstration projects in some low-income countries. By 2014, more than 57 countries had included the HPV vaccine in their national health programmes. Data from several countries have shown the effect of vaccination on @entity1083 and associated disease, and provided evidence of herd immunity. Expansion of programmes to countries with the highest burden of disease is beginning, but further efforts are needed to realise the potential of HPV vaccines.

title: Present status of XXXX vaccine development and implementation.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['infection and pre-cancer', 'oropharyngeal cancers', 'cervical cancers']

entities_list: @entity1083 :: ('MESH:D030361', 'Disease') :: ['HPV infection']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']

answer: @entity1082 :: (10566,Species) :: ['human papillomavirus']


abstract: OBJECTIVE: @entity12767 ( @entity12767 ) play pivotal roles in outbreak responses. @entity2598 ( @entity2598 ) outbreak spread to Lagos, Nigeria, in July 2014, infecting 11 @entity12767 (case fatality rate of 45%). This study was conducted during the outbreak to assess @entity12767 ' @entity2598 -related knowledge and practices. METHODS: A health facility-based cross-sectional study was conducted among @entity12767 across Lagos State using stratified sampling technique. An interviewer-administered questionnaire was administered to elicit respondents' socio-demographic characteristics, knowledge and practices. A checklist assessing health facility's level of preparedness and @entity12767 ' @entity2598 -related training was employed. @entity12767 ' knowledge and practices were scored and classified as either good or poor. Multivariate analysis was performed with confidence interval set at 95%. RESULTS: A total of 112 health facilities with 637 @entity12767 were recruited. Mean age of respondents was 40.1      10.9  years. Overall, 72.5% had good knowledge; doctors knew most. However, only 4.6% of @entity12767 reported good practices. 16.6% reported having been trained in identifying suspected @entity2598 @entity1 (s); 12.2% had a triaging area for febrile @entity1 in their facilities. Higher proportions of @entity12767 with good knowledge and training reported good practices. @entity12767 with @entity2598 -related training were three times more likely to adopt good practices. CONCLUSION: Lagos State @entity12767 had good knowledge of @entity2598 without a corresponding level of good practices. Training was a predictor of good practices.

title: XXXX - gaps in knowledge and practice among healthcare workers in Lagos, August 2014.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity12767 :: ('MESH:D000382', 'Disease') :: ['HCWs', 'Healthcare workers']

entities_list: @entity2598 :: ('MESH:D019142', 'Disease') :: ['Ebola virus disease', 'EVD']

answer: @entity2598 :: (MESH:D019142,Disease) :: ['Ebola virus disease']