abstract: BACKGROUND: Fracture of the hip (HF) is a significant cause of morbidity and mortality in elderly individuals. HF is an acute stress that triggers a state of @entity32 which may affect immune responses and physical recovery. METHODS: Longitudinal study of the impact of HF on the functions of polymorphonuclear neutrophils (PMNs) in elderly subjects. Data were recorded prior to surgery, 6weeks and 6months later. RESULTS: PMN functions were severely impaired shortly after HF ( @entity6722 , phagocytosis, @entity224 production) but there was a time-related recovery of some PMN functions ( @entity6722 , phagocytosis) over time, except in the case of @entity224 production. Whereas FcyRII ( @entity222 ) expression remained unchanged, FcyRIII ( @entity4071 ) increased from low values before surgery to levels of controls 6months post-surgery. This was also the case for the C5a complement receptor and @entity9536 . @entity2938 and @entity2939 expressions were unchanged. Cytokine and chemokine secretions by stimulated PMN were altered. @entity310 and @entity688 secretions were increased following HF but @entity687 secretion was decreased. @entity73 prior to surgery were related to alterations in PI3K and NF-kB signaling pathways. Recovery of these functions paralleled increased PI3K activity, although @entity224 production remained low. Sustained activation of the NF-kB pathway by @entity310 has been reported to involve upregulation of IKKb kinase activity. Activated IKKb kinase inhibits @entity1366 and results in concomitant downstream inhibition of @entity1110 oxidase complex which can account for sustained impaired production of ROS in HF @entity1 . CONCLUSION: Our data showed that the stress caused by HF negatively affects initial PMN responses shortly after the event and that may negatively influence clinical outcomes such as resolving long-term @entity32 and recovery, as well as explaining susceptibility to @entity1292 .

title: Altered neutrophil functions in elderly XXXX during a 6-month follow-up period after a hip fracture.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity6722 :: ('MESH:C565534', 'Disease') :: ['chemotaxis']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['Impaired PMN functions']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

entities_list: @entity1292 :: ('MESH:D009894', 'Disease') :: ['opportunistic infections']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity703 have been shown to contain a population of @entity5 stem cells (CSCs) that present self-renewing capacity and support @entity5 growth and @entity3 . CSCs were shown to secrete large amount of extracellular vesicles (EVs) that can transfer several molecules (proteins, lipids and nucleic acids) and induce epigenetic changes in target cells. Mesenchymal Stromal Cells (MSCs) are susceptible to @entity5 signalling and can be recruited to @entity5 regions. The precise role of MSCs in @entity5 development is still under debate since both pro- and anti-tumorigenic effects have been reported. In this study we analysed the participation of renal CSC-derived EVs in the interaction between @entity5 and MSCs. We found that CSC-derived EVs promoted persistent phenotypical changes in MSCs characterized by an increased expression of genes associated with cell migration ( @entity436 , @entity4112 ), matrix remodeling ( @entity19787 ), angiogenesis and @entity5 growth ( @entity687 , @entity1096 and @entity3335 ). EV-stimulated MSCs exhibited in vitro an enhancement of migration toward the @entity5 conditioned medium. Moreover, EV-stimulated MSCs enhanced migration of @entity703 cells and induced vessel-like formation. In vivo, EV-stimulated MSCs supported @entity5 development and vascularization, when co-injected with @entity703 cells. In conclusion, CSC-derived EVs induced phenotypical changes in MSCs that are associated with @entity5 growth.

title: Extracellular vesicles derived from XXXX stem cells induce a pro-tumorigenic phenotype in mesenchymal stromal cells.

entities_list: @entity3335 :: ('4353', 'Gene') :: ['Myeloperoxidase']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['renal tumor', 'Renal carcinomas']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity703 :: (MESH:D007680,Disease) :: ['renal cancer']


abstract: OBJECTIVES: @entity1 reported outcomes (PROs) are relevant in rheumatology. Variable accessibility and validity of commonly used PROs are obstacles to homogeneity in evidence synthesis. The objective of this project was to provide a comprehensive library of "validated PROs". METHODS: A launch meeting with rheumatologists, PROs methodological experts, and @entity1 , was held to define the library's aims and scope, and basic requirements. To feed the library we performed systematic reviews on selected diseases and domains. Relevant information on PROs was collected using standardised data collection forms based on the COSMIN checklist. RESULTS: The EULAR Outcomes Measures Library (OML), whose aims are to provide and to advise on PROs on a user-friendly manner albeit based on scientific grounds, has been launched and made accessible to all. PROs currently included cover any domain and, are generic or specifically target to the following diseases: @entity309 , @entity571 , @entity1691 , @entity1643 , @entity1252 , @entity210 , @entity170 , @entity4932 , and @entity239 . Up to 236 instruments (106 generic and 130 specific) have been identified, evaluated, and included. The systematic review for @entity1252 , which yielded 10 specific instruments, is presented here as an example. The OML website includes, for each PRO, information on the construct being measured and the extent of validation, recommendations for use, and available versions; it also contains a glossary on common validation terms. CONCLUSIONS: The OML is an in progress library led by rheumatologists, related professionals and @entity1 , that will help to better understand and apply @entity85 .

title: The EULAR Outcome Measures Library: development and an example from a systematic review for XXXX instruments.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus']

entities_list: @entity4932 :: ('MESH:D001171', 'Disease') :: ['juvenile idiopathic arthritis']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['spondyloarthritis']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['PROs in rheumatic and musculoskeletal diseases']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis']

answer: @entity1252 :: (MESH:D008180,Disease) :: ['systemic lupus erythematous']


abstract: Purpose: @entity1753 following primary surgery is frequently indicated in @entity1 with @entity5 . The aim of this study is to evaluate the role of an MRI-based strategy in avoiding trimodality therapy. Materials and Methods: We retrospectively reviewed all @entity1 with @entity5 treated initially with primary surgery at Seoul National University Hospital. We suggest an alternative triage strategy in which the primary treatment modality is determined based on preoperative MRI findings. Using this strategy, primary surgery is only indicated when there is no evidence of parametrial involvement (PMI) and lymph node @entity3 (LNM) in the MRI results; when there is evidence of either or both of these factors, primary chemoradiation is selected. Assuming that this strategy is applied to our cohort, we evaluate how the rate of trimodality therapy is affected. Results: Of the 254 @entity1 in our sample, 77 (30.3%) had at least one Category 1 risk factor (PMI, LNM, positive resection margin) upon pathologic examination. If the MRI-based strategy had been applied to our cohort, 168 @entity1 would have undergone primary surgery and 86 would have undergone primary chemoradiation. Only 25 @entity1 (9.8%) would have required trimodality therapy based on an indication of at least one Category 1 pathologic risk factor following radical hysterectomy. Conclusion: The inclusion of MRI in the decision-making process for primary treatment modality could have reduced the number of @entity1 requiring trimodality therapy based on the indication of a Category 1 risk factor from 30.3% to 9.8% in our cohort.

title: An Alternative Triage Strategy Based on Preoperative MRI for Avoiding Trimodality Therapy in Stage IB Cervical XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Stage IB cervical cancer']

entities_list: @entity1753 :: ('MESH:D001169', 'Disease') :: ['Adjuvant chemoradiation']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: BACKGROUND: Brain dead organ donors have altered central hemodynamic performance, impaired hormone physiology, exaggerated systemic inflammatory response, end-organ microcirculatory dysfunction, and tissue @entity519 . A new treatment, @entity298 ( @entity298 ), stabilizes vital organ blood flow after conventionally resuscitated shock to improve these derangements. STUDY DESIGN: A prospective case-control study of adjunctive @entity298 compared 26 experimental @entity1 (brain dead organ donors) to 52 controls (protocolized conventionally resuscitated donors). Actual organ procurement rates were compared with the Scientific Registry of Transplant Recipient predicted organ yield per @entity1 . Achievement of donor management goals and effective hepatic blood flow were recorded. RESULTS: Fourteen of 26 (53.8%) @entity1 treated with @entity298 achieved all donor management goals compared with 17 of 52 (32.7%) @entity1 treated with conventionally resuscitated (odds ratio  = 2.4; 95% CI, 0.92-6.3; p  = 0.06). @entity1 treated with @entity298 were more than 2 times as likely to achieve final @entity4095 >100 on 40% FiO2 compared with controls (odds ratio  = 2.8; 95% CI, 1-7.69; p  = 0.03). Also, @entity298 -treated @entity1 required less IV crystalloid during the first 12 hours of management ( @entity298 : 3,167    1,893 mL vs 4,154    2,100 mL; p  = 0.046) and required less vasopressor agents at 12 hours post resuscitation (odds ratio  = 7.7; 95% CI, 0.82-42; p  = 0.02). Direct peritoneal resuscitation @entity1 had enhanced effective hepatic blood flow and significantly higher organs transplanted per donor rates compared with controls (3.7    1.7 vs 3.1    1.3; p  = 0.024). CONCLUSIONS: Direct peritoneal resuscitation reduced IV fluid requirement and IV pressor use as well as increased hepatic blood flow and organs transplanted per donor. Direct peritoneal resuscitation studies show it to be a safe, effective method to augment organ donor resuscitation and additional large-scale trials should be conducted to validate these findings.

title: Addition of direct peritoneal lavage to XXXX cadaver organ donor resuscitation improves organ procurement.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['DPR', 'direct peritoneal resuscitation']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: Our objective was to conduct a systematic review and meta-analysis of studies assessing the diagnostic performance of @entity5 standardized uptake value (SUV) in @entity213 ( @entity213 ), as measured by positron emission tomography. A systematic search of the indexed medical literature was conducted using appropriate keywords to identify relevant studies. Six articles were identified by searching electronic databases. A statistical analysis was performed with RevMan 4.2.2 software. SUV measurement and the SUV threshold for defining high SUV were studied dependently. For each publication, we first obtained an estimate of the relative risk (RR) for comparing @entity1 with a low and those with a high SUV. Subsequently, we aggregated the individual RRs into a combined RR using the fixed-effects model to yield weighted mean pooled estimates with 95% confidence intervals (CIs). Publication bias was assessed with a funnel plot. A total of 6 clinical trials involving 453 @entity1 were included in the meta-analysis. The combined RR from the 6 reports for local control was 0.72 (95% CI: 0.63-0.81). The funnel plot revealed symmetrical distribution, indicating no evidence of significant publication bias. The increase in the SUV of the @entity5 was found to be a poor prognostic marker for @entity1 with @entity213 in the meta-analysis, which requires further confirmation in a meta-analysis based on individual @entity1 data.

title: @entity5 standardized uptake value as a prognostic factor in primary XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']

answer: @entity213 :: (MESH:C535575,Disease) :: ['head and neck squamous cell carcinoma']


abstract: UNASSIGNED: Our objective was to conduct a systematic review and meta-analysis of studies assessing the diagnostic performance of @entity5 standardized uptake value (SUV) in @entity213 ( @entity213 ), as measured by positron emission tomography. A systematic search of the indexed medical literature was conducted using appropriate keywords to identify relevant studies. Six articles were identified by searching electronic databases. A statistical analysis was performed with RevMan 4.2.2 software. SUV measurement and the SUV threshold for defining high SUV were studied dependently. For each publication, we first obtained an estimate of the relative risk (RR) for comparing @entity1 with a low and those with a high SUV. Subsequently, we aggregated the individual RRs into a combined RR using the fixed-effects model to yield weighted mean pooled estimates with 95% confidence intervals (CIs). Publication bias was assessed with a funnel plot. A total of 6 clinical trials involving 453 @entity1 were included in the meta-analysis. The combined RR from the 6 reports for local control was 0.72 (95% CI: 0.63-0.81). The funnel plot revealed symmetrical distribution, indicating no evidence of significant publication bias. The increase in the SUV of the @entity5 was found to be a poor prognostic marker for @entity1 with @entity213 in the meta-analysis, which requires further confirmation in a meta-analysis based on individual @entity1 data.

title: XXXX standardized uptake value as a prognostic factor in primary @entity213 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['Pretreatment tumor']


abstract: UNASSIGNED: Similar to @entity792 , there are clear associations between resistance or susceptibility to @entity5 and the classic human leukocyte antigen (HLA) profile of an individual. HLA-associated susceptibility to childhood @entity981 ( @entity981 ) may provide clues to leukemogenesis in general and to the role of other risk factors. The present study aimed to determine the association between the @entity1533 genotype and susceptibility to @entity981 in @entity1 and to assess the prognostic value of @entity1533 alleles in these @entity1 . This study included 50 @entity981 @entity1 who were consecutively admitted to the Pediatric Oncology Unit of Zagazig University Hospital and 50 gender-matched healthy volunteers as a control group. The @entity1 were subjected to full clinical history, thorough clinical examination and routine laboratory investigations. Molecular @entity1533 typing for @entity1 and controls using the reverse sequence-specific oligonucleotide probe technique was performed. @entity1533 *04 allele frequency was significantly higher in female @entity1 compared to that in female controls (P=0.03) and in @entity1 aged <10 years compared to those aged >= 10 years at the time of diagnosis (P=0.01). @entity1533 *11 allele frequency was significantly higher in high-risk compared to standard-risk @entity1 (P=0.01) and in refractory @entity1 compared to those who achieved remission (P=0.02). In conclusion, the @entity1533 *04 allele appears to be a female-specific susceptibility factor for the acquisition of @entity981 and it may affect the age of onset of @entity981 . In addition, the @entity1533 *11 allele may be of prognostic significance in @entity981 . However, further larger studies are required to support the conclusions drawn from this study.

title: Human leukocyte antigen-DRB1 polymorphism in childhood XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['childhood ALL', 'ALL', 'acute lymphoblastic leukemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune diseases']

answer: @entity981 :: (MESH:D054198,Disease) :: ['acute lymphoblastic leukemia']


abstract: INTRODUCTION: @entity1 exposed to potentially traumatic events (PTEs) are at high risk for developing @entity146 , including @entity1005 ( @entity1005 ), @entity148 ( @entity148 ), @entity308 ( @entity308 ), and @entity734 . However, this risk is not universal. Most @entity1 are resistant (i.e., remain asymptomatic), or recover following a brief symptomatic period. This study examined the psychological factors associated with resistant and recovered outcomes in a sample of high-risk @entity1 exposed to assault-related PTEs. METHOD: One hundred and fifty-nine @entity1 completed the Life Events Checklist and were administered the Structured Clinical Interview for DSM-IV @entity74 . This resulted in three groups: (1) no diagnosis (no past or current @entity146 diagnosis; n  =  56), (2) past diagnosis (a past @entity146 diagnosis, but none currently; n  =  31), and (3) current diagnosis (a current diagnosis of one or more @entity146 ; n  =  72). Groups were compared on sociodemographics, PTE exposure, psychopathology, health-related quality of life (HRQOL), and psychological resilience-related factors. RESULTS: The majority of respondents (79%) did not develop chronic @entity1005 following assault exposure, and the most common @entity146 outcome was @entity308 (30%). High endorsement of mastery and social support were associated with the no diagnosis group; and greater reports of mastery and posttraumatic growth were associated with recovery from a past @entity146 . Furthermore, both resilient groups (i.e., no diagnosis and past diagnosis) scored higher on HRQOL measures compared with the current diagnosis group (P  <  0.001). CONCLUSION: Psychological resilience has ramifications to health and well-being, and identifying these factors has potential to inform preventive strategies and treatment interventions for assault exposed @entity1 .

title: Determinants of psychological resistance and recovery among XXXX exposed to assaultive trauma.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['MDD', 'major depressive disorder']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorders', 'psychiatric disorder']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['posttraumatic stress disorder', 'PTSD']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['general anxiety disorder', 'GAD']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['Axis I Disorders']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['substance-related disorders']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: BACKGROUND: @entity890 ( @entity890 ) is one of the most common disk lesions, inducing @entity1643 ( @entity1643 ). Various therapeutic options have been proposed for treatment of @entity890 ( @entity890 ). Intradiscal injection of @entity1787 has been suggested for treatment of @entity890 . OBJECTIVES: To determine the effect of intradiscal @entity1787 injection on @entity158 score and disability in @entity1 with @entity1643 from disk prolapsed. @entity1 AND METHODS: @entity1 with @entity1643 diagnosed with @entity890 were enrolled in this clinical trial study. After prep and drape the area and under the fluoroscopy guide (c-arm), intradiscal injection of @entity1787 / @entity26 mixture (4 mL, 40   g/mL) was performed. @entity158 score and functional ability of the @entity1 according to @entity717 Index (ODI) were measured prior to the injection (baseline) and then at 2 and 4 weeks and then at 3 and 6 months after the injection. RESULTS: Thirty @entity1 (17 females, 13 males) with the mean age of 58.6 y (range, 42-73 y) enrolled in the study. The mean    standard deviation (SD) of @entity158 score before intervention was 8.1    0.8. After two weeks, it was reduced to 3.2    0.6 (P < 0.001) and finally dropped to 2.0    0.6 sixth months after intervention (P = 0.0001). Functional status of ODI was 28.5    2.1 before intervention and showed significant reduction after two weeks (with the mean of 12.3), and it was almost sustained till sixth months after intervention, with the mean of 11.4 (P = 0.001). CONCLUSIONS: Altogether, @entity1787 had significant positive effects on @entity1 with @entity890 unresponsive to other conservative and minimally invasive treatments.

title: Injection of intradiscal o2-o3 to reduce @entity158 and disability of @entity1 with XXXX due to prolapsed lumbar disk.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain', 'LBP']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability']

entities_list: @entity890 :: ('MESH:D007405', 'Disease') :: ['DH', 'disk herniation', 'Disk herniation']

answer: @entity1643 :: (MESH:D017116,Disease) :: ['low back pain']


abstract: BACKGROUND: @entity890 ( @entity890 ) is one of the most common disk lesions, inducing @entity1643 ( @entity1643 ). Various therapeutic options have been proposed for treatment of @entity890 ( @entity890 ). Intradiscal injection of @entity1787 has been suggested for treatment of @entity890 . OBJECTIVES: To determine the effect of intradiscal @entity1787 injection on @entity158 score and disability in @entity1 with @entity1643 from disk prolapsed. @entity1 AND METHODS: @entity1 with @entity1643 diagnosed with @entity890 were enrolled in this clinical trial study. After prep and drape the area and under the fluoroscopy guide (c-arm), intradiscal injection of @entity1787 / @entity26 mixture (4 mL, 40   g/mL) was performed. @entity158 score and functional ability of the @entity1 according to @entity717 Index (ODI) were measured prior to the injection (baseline) and then at 2 and 4 weeks and then at 3 and 6 months after the injection. RESULTS: Thirty @entity1 (17 females, 13 males) with the mean age of 58.6 y (range, 42-73 y) enrolled in the study. The mean    standard deviation (SD) of @entity158 score before intervention was 8.1    0.8. After two weeks, it was reduced to 3.2    0.6 (P < 0.001) and finally dropped to 2.0    0.6 sixth months after intervention (P = 0.0001). Functional status of ODI was 28.5    2.1 before intervention and showed significant reduction after two weeks (with the mean of 12.3), and it was almost sustained till sixth months after intervention, with the mean of 11.4 (P = 0.001). CONCLUSIONS: Altogether, @entity1787 had significant positive effects on @entity1 with @entity890 unresponsive to other conservative and minimally invasive treatments.

title: Injection of intradiscal o2-o3 to reduce XXXX and disability of @entity1 with @entity1643 due to prolapsed lumbar disk.

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: BACKGROUND: @entity890 ( @entity890 ) is one of the most common disk lesions, inducing @entity1643 ( @entity1643 ). Various therapeutic options have been proposed for treatment of @entity890 ( @entity890 ). Intradiscal injection of @entity1787 has been suggested for treatment of @entity890 . OBJECTIVES: To determine the effect of intradiscal @entity1787 injection on @entity158 score and disability in @entity1 with @entity1643 from disk prolapsed. @entity1 AND METHODS: @entity1 with @entity1643 diagnosed with @entity890 were enrolled in this clinical trial study. After prep and drape the area and under the fluoroscopy guide (c-arm), intradiscal injection of @entity1787 / @entity26 mixture (4 mL, 40   g/mL) was performed. @entity158 score and functional ability of the @entity1 according to @entity717 Index (ODI) were measured prior to the injection (baseline) and then at 2 and 4 weeks and then at 3 and 6 months after the injection. RESULTS: Thirty @entity1 (17 females, 13 males) with the mean age of 58.6 y (range, 42-73 y) enrolled in the study. The mean    standard deviation (SD) of @entity158 score before intervention was 8.1    0.8. After two weeks, it was reduced to 3.2    0.6 (P < 0.001) and finally dropped to 2.0    0.6 sixth months after intervention (P = 0.0001). Functional status of ODI was 28.5    2.1 before intervention and showed significant reduction after two weeks (with the mean of 12.3), and it was almost sustained till sixth months after intervention, with the mean of 11.4 (P = 0.001). CONCLUSIONS: Altogether, @entity1787 had significant positive effects on @entity1 with @entity890 unresponsive to other conservative and minimally invasive treatments.

title: Injection of intradiscal o2-o3 to reduce @entity158 and disability of XXXX with @entity1643 due to prolapsed lumbar disk.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: The miR-200 family promotes the epithelial state by suppressing the @entity14904 / @entity14905 epithelial gene transcriptional repressors. To identify other miR-200-regulated genes, we isolated mRNAs bound to transfected biotinylated @entity46066 in @entity19 @entity0 cells. In all, 520 mRNAs were significantly enriched in @entity46066 binding at least twofold. Putative miR-200-regulated genes included @entity14905 , enriched 3.5-fold in the pull down. However, @entity14905 knockdown does not fully recapitulate @entity46066 overexpression, suggesting that regulating other miR-200 targets contributes to miR-200's enhancement of epithelial gene expression. Candidate genes were highly enriched for @entity46066 seed pairing in their 3'UTR and coding sequence and for genes that were downregulated by @entity46066 overexpression. @entity12841 and downstream MAPK signaling pathways were the most enriched pathways. Genes whose products mediate transforming growth factor (TGF)-b signaling were also significantly overrepresented, and miR-200 counteracted the suppressive effects of @entity641 and @entity8385 ( @entity8385 ) on epithelial gene expression. @entity46066 regulated the 3'UTRs of 12 of 14 putative @entity46066 -binding mRNAs tested. The extent of mRNA binding to @entity46066 strongly correlated with gene suppression. Twelve targets of @entity46066 ( @entity71284 , @entity71285 , @entity14570 , @entity9682 , @entity71286 , @entity71287 /14-3-3y, Ywhab/14-3-3b, @entity21602 , @entity31002 , @entity2989 , @entity35824 , @entity22575 ) were experimentally validated by identifying their 3'UTR miR-200 recognition elements. @entity14570 and @entity21602 form a complex with @entity14905 and Ywhab/14-3-3b and @entity71287 /14-3-3y form a complex with @entity22575 . These complexes that repress transcription assemble on epithelial gene promoters. miR-200 overexpression induced RNA polymerase II localization and reduced @entity14905 and @entity22575 binding to epithelial gene promoters. Expression of miR-200-resistant @entity21602 modestly, but significantly, reduced epithelial gene induction by miR-200. miR-200 expression and @entity14905 knockdown are known to inhibit cell invasion in in vitro assays. Knockdown of each of three novel miR-200 target genes identified here, @entity21602 , @entity71287 and @entity71284 , also profoundly suppressed cell invasion. Thus, miR-200 suppresses @entity641 /BMP signaling, promotes epithelial gene expression and suppresses cell invasion by regulating a network of genes.Oncogene advance online publication, 23 March 2015; doi:10.1038/onc.2015.69.

title: miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the XXXX and @entity22575 transcriptional repressor complexes.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity12841 :: ('13649(Tax:10090)', 'Gene') :: ['Epidermal growth factor receptor']

answer: @entity14905 :: (24136(Tax:10090),Gene) :: ['Zeb2']


abstract: UNASSIGNED: The miR-200 family promotes the epithelial state by suppressing the @entity14904 / @entity14905 epithelial gene transcriptional repressors. To identify other miR-200-regulated genes, we isolated mRNAs bound to transfected biotinylated @entity46066 in @entity19 @entity0 cells. In all, 520 mRNAs were significantly enriched in @entity46066 binding at least twofold. Putative miR-200-regulated genes included @entity14905 , enriched 3.5-fold in the pull down. However, @entity14905 knockdown does not fully recapitulate @entity46066 overexpression, suggesting that regulating other miR-200 targets contributes to miR-200's enhancement of epithelial gene expression. Candidate genes were highly enriched for @entity46066 seed pairing in their 3'UTR and coding sequence and for genes that were downregulated by @entity46066 overexpression. @entity12841 and downstream MAPK signaling pathways were the most enriched pathways. Genes whose products mediate transforming growth factor (TGF)-b signaling were also significantly overrepresented, and miR-200 counteracted the suppressive effects of @entity641 and @entity8385 ( @entity8385 ) on epithelial gene expression. @entity46066 regulated the 3'UTRs of 12 of 14 putative @entity46066 -binding mRNAs tested. The extent of mRNA binding to @entity46066 strongly correlated with gene suppression. Twelve targets of @entity46066 ( @entity71284 , @entity71285 , @entity14570 , @entity9682 , @entity71286 , @entity71287 /14-3-3y, Ywhab/14-3-3b, @entity21602 , @entity31002 , @entity2989 , @entity35824 , @entity22575 ) were experimentally validated by identifying their 3'UTR miR-200 recognition elements. @entity14570 and @entity21602 form a complex with @entity14905 and Ywhab/14-3-3b and @entity71287 /14-3-3y form a complex with @entity22575 . These complexes that repress transcription assemble on epithelial gene promoters. miR-200 overexpression induced RNA polymerase II localization and reduced @entity14905 and @entity22575 binding to epithelial gene promoters. Expression of miR-200-resistant @entity21602 modestly, but significantly, reduced epithelial gene induction by miR-200. miR-200 expression and @entity14905 knockdown are known to inhibit cell invasion in in vitro assays. Knockdown of each of three novel miR-200 target genes identified here, @entity21602 , @entity71287 and @entity71284 , also profoundly suppressed cell invasion. Thus, miR-200 suppresses @entity641 /BMP signaling, promotes epithelial gene expression and suppresses cell invasion by regulating a network of genes.Oncogene advance online publication, 23 March 2015; doi:10.1038/onc.2015.69.

title: miR-200 promotes the mesenchymal to epithelial transition by suppressing multiple members of the @entity14905 and XXXX transcriptional repressor complexes.

answer: @entity22575 :: (20613(Tax:10090),Gene) :: ['Snail1']


abstract: UNASSIGNED: Transmission of drug-resistant pathogens presents an almost-universal challenge for fighting @entity166 . Transmitted drug resistance mutations (TDRM) can persist in the absence of drugs for considerable time. It is generally believed that differential TDRM-persistence is caused, at least partially, by variations in TDRM-fitness-costs. However, in vivo epidemiological evidence for the impact of fitness costs on TDRM-persistence is rare. Here, we studied the persistence of TDRM in @entity2858 using longitudinally-sampled @entity377 sequences from the Swiss- @entity645 -Cohort-Study (SHCS). All treatment-na  ve individuals with TDRM at baseline were included. Persistence of TDRM was quantified via reversion rates (RR) determined with interval-censored survival models. Fitness costs of TDRM were estimated in the genetic background in which they occurred using a previously published and validated machine-learning algorithm (based on in vitro replicative capacities) and were included in the survival models as explanatory variables. In 857 sequential samples from 168 treatment-na  ve @entity1 , 17 TDRM were analyzed. RR varied substantially and ranged from 174.0/100- @entity1 -years;CI=[51.4, 588.8] (for 184V) to 2.7/100- @entity1 -years;[0.7, 10.9] (for 215D). RR increased significantly with fitness cost (increase by 1.6[1.3,2.0] per standard deviation of fitness costs). When subdividing fitness costs into the average fitness cost of a given mutation and the deviation from the average fitness cost of a mutation in a given genetic background, we found that both components were significantly associated with reversion-rates. Our results show that the substantial variations of TDRM persistence in the absence of drugs are associated with fitness-cost differences both among mutations and among different genetic backgrounds for the same mutation.

title: Persistence of Transmitted XXXX Drug Resistance Mutations Associated with Fitness Costs and Viral Genetic Backgrounds.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'person']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity166 :: ('MESH:D003141', 'Disease') :: ['infectious diseases']

answer: @entity2858 :: (11676,Species) :: ['HIV-1']


abstract: UNASSIGNED: Tumor progression depends on @entity5 milieu, which influences neovasculature formation and immunosuppression. Combining immunotherapy with antiangiogenic/antivascular therapy might be an effective therapeutic approach. The aim of our study was to elaborate an anticancer therapeutic strategy based on the induction of immune response which leads to polarization of @entity5 milieu. To achieve this, we developed a @entity5 cell-based vaccine. @entity20770 peptide was used as a B16-F10 cell death-inducing agent. The lysates were used as a vaccine to immunize @entity19 bearing B16-F10 @entity320 . To further improve the therapeutic effect of the vaccine, we combined it with interleukin (IL)-12 gene therapy. IL-12, a cytokine with antiangiogenic properties, activates nonspecific and specific immune responses. We observed that combined therapy is significantly more effective (as compared with monotherapies) in inhibiting @entity5 growth. Furthermore, the tested combination polarizes the @entity5 microenvironment, which results in a switch from a proangiogenic/immunosuppressive to an antiangiogenic/immunostimulatory one. The switch manifests itself as a decreased number of @entity5 blood vessels, increased levels of @entity5 -infiltrating @entity1961 (+), CD8(+) and NK cells, as well as lower level of suppressor lymphocytes (Treg). Our results suggest that polarizing @entity5 milieu by such combined therapy does inhibit @entity5 growth and seems to be a promising therapeutic strategy.

title: Combined Tumor Cell-Based Vaccination and Interleukin-12 Gene Therapy Polarizes the Tumor Microenvironment in XXXX .

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma tumors']

answer: @entity19 :: (10090,Species) :: ['Mice']


abstract: @entity242 ( @entity242 ) is a rare @entity8650 occurring in the distal extremities of young adults and is characterized histologically by nodules of epithelioid cells showing central @entity39 . Intra-articular @entity242 is extremely rare; only four cases have been reported, but their radiologic and histologic documentation of intra-articular origin have been imprecise. We report the first radiologically and histologically well-documented case of primary synovial @entity242 . A 59-year-old @entity1 presented with @entity158 followed by swelling of her right knee for 6  months. MRI revealed an entirely intra-articular nodular synovial mass in the lateral part of the right knee joint in a background of diffusely thickened synovium. Synovectomy was performed under the clinical impression of @entity1362 ( @entity1362 ), a diagnosis erroneously confirmed by the reporting pathologist. The @entity5 rapidly recurred 3  months afterward and the diagnosis of primary synovial @entity242 was made. Despite above-knee amputation, the @entity5 continued to spread proximally to the retroperitoneum. She developed multiple lung metastases and died 20  months after initial presentation. The nodular aggregates of @entity5 cells with central @entity39 resulted in diffuse polypoid synovial thickening mimicking @entity378 and @entity1362 . The @entity5 cells showed positive staining for EMA, @entity4166 , @entity2280 , and complete loss of @entity6195 staining, establishing the diagnosis of primary synovial @entity242 . The @entity242 spread from the synovium to and along the joint capsule, and then extra-articularly into the soft tissue surrounding the knee joint, with lymphovascular permeation. Such pattern of spread calls for radical surgical excision as the treatment of choice.

title: Primary synovial epithelioid sarcoma of the knee: distinctly unusual location leading to its confusion with XXXX .

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['ES', 'Epithelioid sarcoma']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity8650 :: ('MESH:D012983', 'Disease') :: ['malignant soft tissue tumor']

entities_list: @entity1362 :: ('MESH:D013586', 'Disease') :: ['pigmented villonodular synovitis', 'PVNS']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculous synovitis']

answer: @entity1362 :: (MESH:D013586,Disease) :: ['pigmented villonodular synovitis']


abstract: INTRODUCTION: Surgical treatment of intestinal @entity2403 ( @entity2403 ) is not well established. Specifically, it is still difficult to assess the clinical value of laparoscopic surgery to address this condition. We aimed to evaluate the clinical course and the characteristics of laparoscopic surgery for intestinal @entity2403 compared with open surgery. METHODS: We reviewed charts of 91 @entity1 who underwent surgical treatment for intestinal @entity2403 between January 1995 and December 2012. We retrospectively compared the laparoscopic group (LG, n  =  30) and the open group (OG, n  =  61) in terms of @entity1 demographics, clinical features, operative data, postoperative course, complications within 30  days after operation, and long-term follow-up data. RESULTS: There were more females in the LG than in the OG (63.3 vs. 36.1  %, p  =  0.014), and @entity9645 were more frequent in the LG (76.7 vs. 54.1  %, p  =  0.038; 60 vs. 36.1  %, p  =  0.031). Intractability with medical treatment was dominant in the LG (76.7 vs. 45.9  %, p  =  0.02), while intestinal perforation or @entity292 were more prevalent in the OG (10 vs. 44.3  %, p  =  0.001). Most @entity1 received an ileocecectomy or a right hemicolectomy as their first surgery. In the LG, the @entity1 had a shorter operation time (162.0 vs. 228.5  min, p  <  0.001) and had less @entity190 (61.7 vs. 232.3  ml, p  =  0.003). There were no significant @entity260 , reoperation, mortality, and hospital stay between the groups. During the follow-up period, the mean number of operations was less in the LG than in the OG (1.3 vs. 2.1, p  =  0.011). Analysis indicated that 20  % of @entity1 in the LG and 50.8  % in the OG underwent more than two operations (p  =  0.005). CONCLUSION: Laparoscopic surgery is feasible and safe for selected intestinal @entity2403 @entity1 . However, there were no better short-term outcomes in LG compared with OG.

title: Short- and long-term outcomes of laparoscopic surgery for intestinal XXXX : a comparative study with open surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity9645 :: ('MESH:D019226', 'Disease') :: ['oral/genital ulcers']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['differences in postoperative complications']

entities_list: @entity2403 :: ('MESH:D001528', 'Disease') :: ['BD', "Behcet's disease"]

answer: @entity2403 :: (MESH:D001528,Disease) :: ['Behcet's disease']


abstract: OBJECTIVES: Individual differences in underlying, "basal" @entity158 sensitivity are large and have clinical implications. Some studies have suggested that @entity158 sensitivity may also predict the outcome of @entity158 treatment. @entity1118 management programs are effective, but treatment success is individually very different. Therefore, identification of predictors of treatment success is important. This study investigated if @entity158 sensitivity predicted the outcome of a 4-week outpatient multidisciplinary @entity158 management program. DESIGN: Cohort study. SETTING: @entity1118 outpatient clinic at the Department of Anesthesiology, Intensive Care Medicine and Pain Therapy of the University of M  nster. METHODS: @entity158 sensitivity was measured at treatment onset, using comprehensive experimental @entity158 testing (thermal, pressure, and @entity158 ) and the @entity158 sensitivity questionnaire. Primary (clinical @entity158 intensity) and secondary ( @entity308 , @entity148 , @entity158 ) outcome parameters were assessed at treatment start, at discharge and 6 months later. SUBJECTS: Sixty five adult chronic @entity158 @entity1 with mixed @entity158 diagnoses. RESULTS: There were significant improvements in clinical @entity158 intensity (from 6.1        2.0 to 5.1        1.8 [0-10]), @entity308 and @entity148 at discharge (all P   <   0.001) and of clinical @entity158 intensity (to 5.3        2.3 [0-10]) and @entity158 at 6 months (all P   <   0.05). However, treatment outcome was not predicted by any of the @entity158 sensitivity measures. DISCUSSION: Results show that @entity158 sensitivity is not a reliable predictor of treatment outcome in mixed diagnosis multidisciplinary @entity158 management programs, possibly due to the heterogeneity of @entity1 enrolled in such programs. Clinically useful predictors of treatment success in this setting remain to be identified.

title: Basal Pain Sensitivity does not Predict the Outcome of XXXX Treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain-related disability', 'Basal pain', 'pinprick pain', 'pain', 'basal pain']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['Chronic pain', 'Multidisciplinary chronic pain']

answer: @entity1118 :: (MESH:D059350,Disease) :: ['Multidisciplinary Chronic Pain']


abstract: BACKGROUND: The high recurrence rate of chronic @entity3179 has a significant impact on an individual's quality of life and healthcare costs. OBJECTIVES: This study aimed to identify risk and protective factors for recurrence of @entity3179 using a theoretical approach by applying a framework of self and family management of chronic conditions to underpin the study. DESIGN: Secondary analysis of combined data collected from three previous prospective longitudinal studies. SETTING: The contributing studies' @entity1 were recruited from two metropolitan hospital outpatient wound clinics and three community-based wound clinics. @entity1 : Data were available on a sample of 250 adults, with a leg @entity1066 of primarily venous aetiology, who were followed after @entity1066 for a median follow-up time of 17 months after healing (range: 3-36 months). METHODS: Data from the three studies were combined. The original @entity1 data were collected through medical records and self-reported questionnaires upon healing and every 3 months thereafter. A Cox proportion-hazards regression analysis was undertaken to determine the influential factors on leg @entity1066 recurrence based on the proposed conceptual framework. RESULTS: The median time to recurrence was 42 weeks (95% CI 31.9-52.0), with an incidence of 22% (54 of 250 @entity1 ) recurrence within three months of healing, 39% (91 of 235 @entity1 ) for those who were followed for six months, 57% (111 of 193) by 12 months, 73% (53 of 72) by two years and 78% (41 of 52) of those who were followed up for three years. A Cox proportional-hazards regression model revealed that the risk factors for recurrence included a history of @entity1150 (HR 1.7, 95% CI 1.07-2.67, p=0.024), history of multiple previous leg ulcers (HR 4.4, 95% CI 1.84-10.5, p=0.001), and longer duration (in weeks) of previous @entity1066 (HR 1.01, 95% CI 1.003-1.01, p<0.001); while the protective factors were elevating legs for at least 30min per day (HR 0.33, 95% CI 0.19-0.56, p<0.001), higher levels of self-efficacy (HR 0.95, 95% CI 0.92-0.99, p=0.016), and walking around for at least 3h/day (HR 0.66, 95% CI 0.44-0.98, p=0.040). CONCLUSIONS: Results from this study provide a comprehensive examination of risk and protective factors associated with leg @entity1066 recurrence based on the chronic disease self and family management framework. These results in turn provide essential steps towards developing and testing interventions to promote optimal prevention strategies for @entity3179 .

title: Identifying risk factors and protective factors for XXXX using a theoretical approach: A longitudinal study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'participant', 'PARTICIPANTS']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulcer', 'ulcer healing']

entities_list: @entity3179 :: ('MESH:D014647', 'Disease') :: ['venous leg ulcer recurrence', 'venous leg ulcers']

answer: @entity3179 :: (MESH:D014647,Disease) :: ['venous leg ulcer recurrence']


abstract: BACKGROUND: The purpose of this study was to observe the role of secondary cytoreductive surgery in @entity902 -resistant recurrent @entity43 ( @entity43 ) @entity1 . METHODS: We collected data of @entity1 affected by recurrent @entity43 treated between 1995 and 2013. Inclusion criteria were: invasive epithelial @entity43 histologically documented, cytoreductive surgery and @entity902 -based chemotherapy at first-line treat ment with evidence of complete response to treatment, disease-free interval <6  months, and no concomitant @entity5 . @entity1 considered susceptible of cytoreductive surgery (group A) were compared with a historical series of @entity1 with similar characteristics but not eligible for surgery (group B). RESULTS: Of 122 @entity902 -resistant @entity1 , 18 met the inclusion criteria for the study and were enrolled. They were compared with a historical series of 18 @entity1 not surgically treated with analogous clinical and pathological features. The most frequent sites of relapse included pelvic and aortic lymph nodes (39  %), peritoneum (33  %), bowel (28  %), and pelvis (22  %). A low rate of @entity260 was reported. No deaths were recorded. Overall survival was significantly longer in cytoreductive group when compared with the control group (P  =  0.035). Median overall survival was 44  months. Estimated 5-year overall survival rates were 57 versus 23.5  % for groups A and B, respectively. CONCLUSIONS: Surgery could represent a useful adjunct to chemotherapy in the management of @entity902 -resistant recurrent @entity43 @entity1 , carefully selected, in highly selected centers. Larger prospective trials are needed to further confirm our experience.

title: Secondary Cytoreduction in @entity902 -Resistant Recurrent XXXX : A Single-Institution Experience.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['OC', 'ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasia']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['intraoperative and postoperative complications']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity43 :: (MESH:D010051,Disease) :: ['Ovarian Cancer']


abstract: BACKGROUND: The purpose of this study was to observe the role of secondary cytoreductive surgery in @entity902 -resistant recurrent @entity43 ( @entity43 ) @entity1 . METHODS: We collected data of @entity1 affected by recurrent @entity43 treated between 1995 and 2013. Inclusion criteria were: invasive epithelial @entity43 histologically documented, cytoreductive surgery and @entity902 -based chemotherapy at first-line treat ment with evidence of complete response to treatment, disease-free interval <6  months, and no concomitant @entity5 . @entity1 considered susceptible of cytoreductive surgery (group A) were compared with a historical series of @entity1 with similar characteristics but not eligible for surgery (group B). RESULTS: Of 122 @entity902 -resistant @entity1 , 18 met the inclusion criteria for the study and were enrolled. They were compared with a historical series of 18 @entity1 not surgically treated with analogous clinical and pathological features. The most frequent sites of relapse included pelvic and aortic lymph nodes (39  %), peritoneum (33  %), bowel (28  %), and pelvis (22  %). A low rate of @entity260 was reported. No deaths were recorded. Overall survival was significantly longer in cytoreductive group when compared with the control group (P  =  0.035). Median overall survival was 44  months. Estimated 5-year overall survival rates were 57 versus 23.5  % for groups A and B, respectively. CONCLUSIONS: Surgery could represent a useful adjunct to chemotherapy in the management of @entity902 -resistant recurrent @entity43 @entity1 , carefully selected, in highly selected centers. Larger prospective trials are needed to further confirm our experience.

title: Secondary Cytoreduction in XXXX -Resistant Recurrent @entity43 : A Single-Institution Experience.

answer: @entity902 :: (MESH:D010984,Chemical) :: ['Platinum']


abstract: OBJECTIVE: In the medical literature, @entity1514 has traditionally been considered a rare occurrence. We hypothesise that the incidence of such protrusions and their abdominal symptoms is higher than is generally believed and that their presence may account for a significant proportion of chronic @entity490 . Accordingly, the present study was designed to identify and quantify the symptoms experienced by @entity1 with @entity1514 and to assess the relative risk of these symptoms being presented, compared to the general population. DESIGN: We conducted a cross-sectional study with a control group. The following comparison groups were analysed: case group, consisting of 100 @entity1 diagnosed with @entity1514 in our hospital between February 2007 and October 2012, and control group consisting of 100 subjects from the general population, chosen at random. To compare the symptoms observed in each group, the following tests were applied to all study subjects: clinical examination, gastrointestinal-related quality of life (GIQLI) questionnaire and DN4 questionnaire. We also reviewed the subjects' medical records for the previous 3  years. RESULTS: The subjects in the case group had a significantly higher incidence of digestive-urologic symptoms, a poorer gastrointestinal quality of life and greater need of medical care than those in the control group. The differences were statistically significant for all the parameters studied. Almost all the case group subjects suffered chronic @entity490 and/or digestive-urologic symptoms. We term this group of symptoms "chronic @entity2850 ". Nevertheless, in most cases, no neurologic aetiology was suspected, and therefore the treatment given was ineffective. In view of the results obtained, we propose a diagnostic-therapeutic algorithm for such @entity1 . CONCLUSION: @entity1514 disc protrusion, as well as having a non-negligible incidence, is often associated with a digestive-urologic clinical syndrome, and this factor should be taken into account in all cases of chronic @entity490 and other digestive-urologic symptoms when standard tests are negative, so that appropriate treatment may be given.

title: XXXX . Study of 100 cases and proposed diagnostic-therapeutic algorithm.

entities_list: @entity1514 :: ('MESH:D013896', 'Disease') :: ['Thoracic', 'thoracic disc protrusion']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain', 'non-visceral abdominal pains']

entities_list: @entity2850 :: ('MESH:D009408', 'Disease') :: ['abdominal syndrome due to nervous compression']

answer: @entity2850 :: (MESH:D009408,Disease) :: ['Chronic abdominal syndrome due to nervous compression']


abstract: In transplantation studies of Rauscher leukemic SJL/J @entity19 longer @entity1349 ( @entity1349 ) were obtained with spleen cells from syngeneic donors than with marrow. These could be further extended by immunization of the donors to Rauscher virus (RLV) and @entity1778 cells. This suggests that spleen cells exert a greater graft-vs- @entity1778 effect than marrow. Nevertheless, with syngeneic cells all recipients eventually died of @entity1778 relapse. In contrast, the use of RLV-resistant C57BL/10J allogeneic marrow cells resulted in a substantial number of long-term survivors and a low incidence of @entity66 , while the use of pure allogeneic spleen cells resulted in early and fatal GvH response in all recipients. To determine if allogeneic spleen cells might have any demonstrably beneficial effect on survival of leukemic @entity19 various small quantities of C57BL/10J spleen cells were mixed with marrow from the same donors and engrafted into normal and leukemic SJL/J recipients. Among the normal @entity19 @entity1349 decreased as a function of spleen cell concentration. However, with the leukemics the use of 2.5 or 5% spleen cells resulted in later deaths than that found when leukemic @entity19 were given only marrow. Also, for all allogeneic spleen/marrow mixtures tested, survival of leukemic recipients exceeded that of normal recipients given the same cell mixtures. These data suggest a possible beneficial effect of small amounts of allogeneic spleen cells in transplantation therapy for @entity1778 , and a possible competitive interaction of anti-host and anti-leukemic activities of the transplanted cells leading to a moderation of the GvH response.

title: @entity1778 and moderation of graft-vs-host reaction in transplantation therapy of XXXX .

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['Rauscher leukemia', 'leukemia']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['GvH disease']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['median survival times', 'MST']

answer: @entity1778 :: (MESH:D007938,Disease) :: ['viral leukemia']


abstract: In transplantation studies of Rauscher leukemic SJL/J @entity19 longer @entity1349 ( @entity1349 ) were obtained with spleen cells from syngeneic donors than with marrow. These could be further extended by immunization of the donors to Rauscher virus (RLV) and @entity1778 cells. This suggests that spleen cells exert a greater graft-vs- @entity1778 effect than marrow. Nevertheless, with syngeneic cells all recipients eventually died of @entity1778 relapse. In contrast, the use of RLV-resistant C57BL/10J allogeneic marrow cells resulted in a substantial number of long-term survivors and a low incidence of @entity66 , while the use of pure allogeneic spleen cells resulted in early and fatal GvH response in all recipients. To determine if allogeneic spleen cells might have any demonstrably beneficial effect on survival of leukemic @entity19 various small quantities of C57BL/10J spleen cells were mixed with marrow from the same donors and engrafted into normal and leukemic SJL/J recipients. Among the normal @entity19 @entity1349 decreased as a function of spleen cell concentration. However, with the leukemics the use of 2.5 or 5% spleen cells resulted in later deaths than that found when leukemic @entity19 were given only marrow. Also, for all allogeneic spleen/marrow mixtures tested, survival of leukemic recipients exceeded that of normal recipients given the same cell mixtures. These data suggest a possible beneficial effect of small amounts of allogeneic spleen cells in transplantation therapy for @entity1778 , and a possible competitive interaction of anti-host and anti-leukemic activities of the transplanted cells leading to a moderation of the GvH response.

title: XXXX and moderation of graft-vs-host reaction in transplantation therapy of @entity1778 .

answer: @entity1778 :: (MESH:D007938,Disease) :: ['Graft-vs-leukemia']


abstract: @entity10263 @entity6329 group (Lcs) consists of three phylogenetically closely related species ( @entity6329 , @entity6983 , and @entity10263 ), which are widely used in the dairy and probiotic industrial sectors. Strategies to easily and rapidly characterize Lcs are therefore of interest. To this aim, we developed a method according to a technique known as @entity2101 ( @entity2101 ), which was applied to a 150bp groEL gene fragment. The analysis was performed on 53 Lcs strains and 29 strains representatives of species that are commonly present in dairy and probiotic products and can be most probably co-isolated with Lcs strains. DNA amplification was obtained only from Lcs strains, demonstrating the specificity of the groEL primers designed in this study. The @entity2101 clustered Lcs strains in three groups that exactly corresponded to the species of the @entity6329 group. A following @entity2101 separated the 39 @entity6983 strains in two well distinct intraspecific groups, indicating the possible existence of at least two distinct genotypes inside the species. Nonetheless, the phenotypic characterization demonstrated that the genotypes do not correspond to the two @entity6983 , namely paracasei and tolerans. In conclusion, the melting curve analysis developed in this study is demonstrably a simple, labor-saving, and rapid strategy obtain the genotyping of a bacterial isolate and simultaneously potentially confirm its affiliation to the @entity6329 group of species. The application of this method to a larger collection of strains may validate the possibility to use the proposed @entity2101 protocol for the taxonomic discrimination of @entity6329 group of species. In general, this study suggests that @entity2101 can be a suitable technique for the genetic typization of @entity10263 strains.

title: Melting curve analysis of a groEL PCR fragment for the rapid genotyping of strains belonging to the @entity10263 XXXX group of species.

entities_list: @entity10263 :: ('47715', 'Species') :: ['Lactobacillus', 'L. rhamnosus']

entities_list: @entity2101 :: ('MESH:C538394', 'Disease') :: ['high resolution melting analysis', 'HRMa']

entities_list: @entity6983 :: ('1597', 'Species') :: ['L. paracasei subspecies', 'L. paracasei']

answer: @entity6329 :: (1582,Species) :: ['casei']


abstract: @entity10263 @entity6329 group (Lcs) consists of three phylogenetically closely related species ( @entity6329 , @entity6983 , and @entity10263 ), which are widely used in the dairy and probiotic industrial sectors. Strategies to easily and rapidly characterize Lcs are therefore of interest. To this aim, we developed a method according to a technique known as @entity2101 ( @entity2101 ), which was applied to a 150bp groEL gene fragment. The analysis was performed on 53 Lcs strains and 29 strains representatives of species that are commonly present in dairy and probiotic products and can be most probably co-isolated with Lcs strains. DNA amplification was obtained only from Lcs strains, demonstrating the specificity of the groEL primers designed in this study. The @entity2101 clustered Lcs strains in three groups that exactly corresponded to the species of the @entity6329 group. A following @entity2101 separated the 39 @entity6983 strains in two well distinct intraspecific groups, indicating the possible existence of at least two distinct genotypes inside the species. Nonetheless, the phenotypic characterization demonstrated that the genotypes do not correspond to the two @entity6983 , namely paracasei and tolerans. In conclusion, the melting curve analysis developed in this study is demonstrably a simple, labor-saving, and rapid strategy obtain the genotyping of a bacterial isolate and simultaneously potentially confirm its affiliation to the @entity6329 group of species. The application of this method to a larger collection of strains may validate the possibility to use the proposed @entity2101 protocol for the taxonomic discrimination of @entity6329 group of species. In general, this study suggests that @entity2101 can be a suitable technique for the genetic typization of @entity10263 strains.

title: Melting curve analysis of a groEL PCR fragment for the rapid genotyping of strains belonging to the XXXX @entity6329 group of species.

answer: @entity10263 :: (47715,Species) :: ['Lactobacillus']


abstract: BACKGROUND: Optimal management of @entity360 ( @entity360 ) remains unclear. OBJECTIVE: To evaluate diagnostic yields and downstream clinical outcomes comparing video capsule endoscopy (VCE) with push enteroscopy (PE). METHODS: @entity1 with @entity360 and negative esophagogastroduodenoscopies and colonoscopies were randomly assigned to VCE or PE and followed for 12 months. End points included diagnostic yield, @entity548 , health resource utilization and crossovers. RESULTS: Data from 79 @entity1 were analyzed (VCE n=40; PE n=39; 82.3% overt @entity360 ). VCE had greater diagnostic yield (72.5% versus 48.7%; P<0.05), especially in the distal small bowel (58% versus 13%; P<0.01). More VCE-identified lesions were rated possible or certain causes of @entity548 (79.3% versus 35.0%; P<0.05). During follow-up, there were no differences in the rates of ongoing @entity548 (acute [40.0% versus 38.5%; P not significant], chronic [32.5% versus 45.6%; P not significant]), nor in health resource utilization. Fewer VCE-first @entity1 crossed over due to ongoing @entity548 (22.5% versus 48.7%; P<0.05). CONCLUSIONS: A VCE-first approach had a significant diagnostic advantage over PE-first in @entity1 with @entity360 , especially with regard to detecting small bowel lesions, affecting clinical certainty and subsequent further small bowel investigations, with no subsequent differences in @entity548 or resource utilization outcomes in follow-up. These findings question the clinical relevance of many of the discovered endoscopic lesions or the ability to treat most of these effectively over time. Improved prognostication of both @entity1 characteristics and endoscopic lesion appearance with regard to @entity548 behaviour, coupled with the impact of therapeutic deep enteroscopy, is now required using adapted, high-quality study methodologies.

title: Randomized controlled trial comparing outcomes of video capsule endoscopy with push enteroscopy in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['obscure gastrointestinal bleeding', 'OGIB']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'acute or chronic bleeding']

answer: @entity360 :: (MESH:D006471,Disease) :: ['obscure gastrointestinal bleeding']


abstract: BACKGROUND: The role of technology in health care delivery has grown rapidly in the last decade. The potential of mobile telehealth (MTH) to support @entity1 self-management is a key area of research. Providing @entity1 with technological tools that allow for the recording and transmission of health parameters to health care professionals (HCPs) may promote behavior changes that result in improved health outcomes. Although for some conditions the evidence of the effectiveness of MTH is clear, to date the findings on the effects of MTH on @entity6 management remain inconsistent. OBJECTIVE: This study aims to evaluate an MTH intervention among @entity2690 -requiring adults with @entity6 to establish whether supplementing standard care with MTH results in improved health outcomes-glycated hemoglobin (HbA1c), blood pressure (BP), health-related quality of life (HRQoL), @entity6 self-management behaviors, @entity6 health care utilization, and @entity6 self-efficacy and illness beliefs. An additional objective was to explore the acceptability of MTH and @entity1 ' perceptions of, and experience, using it. METHODS: A mixed-method design consisting of a 9-month, two-arm, parallel randomized controlled trial (RCT) was used in combination with exit qualitative interviews. Quantitative data was collected at baseline, 3 months, and 9 months. Additional intervention fidelity data, such as @entity1 ' MTH transmissions and contacts with the MTH nurse during the study, were also recorded. RESULTS: Data collection for both the quantitative and qualitative components of this study has ended and data analysis is ongoing. A total of 86 @entity1 were enrolled into the study. Out of 86 @entity1 , 45 (52%) were randomized to the intervention group and 36 (42%) to the control group. Preliminary data on MTH training sessions and MTH usage by intervention @entity1 are presented in this paper. We expect to publish complete study results in 2015. CONCLUSIONS: The range of data collected in this study will allow for a comprehensive evaluation of processes and outcomes. The early results presented suggest that MTH usage decreases over time and that MTH @entity1 would benefit from attending more than one training session. TRIAL REGISTRATION: ClinicalTrials.gov NCT00922376; http://clinicaltrials.gov/ct2/show/NCT00922376 (Archived by WebCite at http://www.webcitation.org/6Vu4nhLI6).

title: A Mobile Telehealth Intervention for Adults With @entity2690 -Requiring XXXX : Early Results of a Mixed-Methods Randomized Controlled Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: BACKGROUND: The role of technology in health care delivery has grown rapidly in the last decade. The potential of mobile telehealth (MTH) to support @entity1 self-management is a key area of research. Providing @entity1 with technological tools that allow for the recording and transmission of health parameters to health care professionals (HCPs) may promote behavior changes that result in improved health outcomes. Although for some conditions the evidence of the effectiveness of MTH is clear, to date the findings on the effects of MTH on @entity6 management remain inconsistent. OBJECTIVE: This study aims to evaluate an MTH intervention among @entity2690 -requiring adults with @entity6 to establish whether supplementing standard care with MTH results in improved health outcomes-glycated hemoglobin (HbA1c), blood pressure (BP), health-related quality of life (HRQoL), @entity6 self-management behaviors, @entity6 health care utilization, and @entity6 self-efficacy and illness beliefs. An additional objective was to explore the acceptability of MTH and @entity1 ' perceptions of, and experience, using it. METHODS: A mixed-method design consisting of a 9-month, two-arm, parallel randomized controlled trial (RCT) was used in combination with exit qualitative interviews. Quantitative data was collected at baseline, 3 months, and 9 months. Additional intervention fidelity data, such as @entity1 ' MTH transmissions and contacts with the MTH nurse during the study, were also recorded. RESULTS: Data collection for both the quantitative and qualitative components of this study has ended and data analysis is ongoing. A total of 86 @entity1 were enrolled into the study. Out of 86 @entity1 , 45 (52%) were randomized to the intervention group and 36 (42%) to the control group. Preliminary data on MTH training sessions and MTH usage by intervention @entity1 are presented in this paper. We expect to publish complete study results in 2015. CONCLUSIONS: The range of data collected in this study will allow for a comprehensive evaluation of processes and outcomes. The early results presented suggest that MTH usage decreases over time and that MTH @entity1 would benefit from attending more than one training session. TRIAL REGISTRATION: ClinicalTrials.gov NCT00922376; http://clinicaltrials.gov/ct2/show/NCT00922376 (Archived by WebCite at http://www.webcitation.org/6Vu4nhLI6).

title: A Mobile Telehealth Intervention for Adults With XXXX -Requiring @entity6 : Early Results of a Mixed-Methods Randomized Controlled Trial.

answer: @entity2690 :: (3630,Gene) :: ['Insulin']


abstract: The difficulties in assessing the teratogenic potential of drugs used during pregnancy have been made evident by experiences with @entity2816 and @entity4742 ( @entity4743 ). In the case of @entity2816 , the drug's ability to cause @entity4219 tended to be species specific, and thus animal studies were unreliable indicators of teratogenicity in @entity1 . With DES, the delayed appearance of injury, almost a generation after birth, indicates that short-term studies may fail to reveal serious effects. In both cases only the otherwise rare occurrence of the condition led to the suspicion of a cause-and-effect relationship. Although wide-spread use of drugs such as LSD, heroin, and marijuana has necessitated assessment of their teratogenic potential, a controlled investigation of their effects has so far been impossible to conduct. Both @entity286 and @entity167 have been associated with adverse effects on the fetus and neonate, but the precise mechanisms by which these effects occur are as yet unclear. There is also reason for concern about the teratogenic potential of environmental pollutants such as organic @entity349 compounds, lead, and radiation. Furthermore, the fetus may potentially be harmed if a particular drug is not administered (eg, insulin for @entity6 during pregnancy). In the final analysis, any potential benefits of therapy for the mother must be weighed against known and unknown risks to the @entity1 . Rational management requires an understanding of the physiologic and pharmacologic principles involved in each case and careful and judicious selection of drug therapy.

title: In vivo assessment of the teratogenic potential of drugs in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'infant']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity349 :: ('MESH:D008628', 'Chemical') :: ['mercury']

entities_list: @entity2816 :: ('MESH:D013792', 'Chemical') :: ['thalidomide']

entities_list: @entity4219 :: ('MESH:D004480', 'Disease') :: ['phocomelia']

entities_list: @entity4742 :: ('MESH:D004054', 'Chemical') :: ['diethylstilbestrol']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: UNASSIGNED: Prescription opioid and @entity29908 have been increasing steadily year after year, and continue to be a serious national problem. A sequela of the increase in @entity4784 has been an increase in the number of @entity1 born with @entity4784 . These @entity1 often require costly, prolonged stays in the neonatal intensive care unit (NICU) for drug withdrawal treatment. The authors studied a population of @entity1 from a large Medicaid health plan who were born with @entity6767 ( @entity6767 ) secondary to in utero opioid exposure to assess the average length of stay in the NICU, and to determine the variables that may account for differences in interinstitutional lengths of stay. The overall average length of stay for @entity6767 was 21.1 days for the 139 @entity1 included in the study. Analysis of the medication used for treatment revealed that @entity1 who were treated with a combined inpatient/outpatient regimen with @entity284 had an average length of stay of 11.4 days versus 25.1 days for @entity1 who were treated entirely as inpatients (P<0.001), a 55% reduction in average length of stay. In 2009 there were an estimated 13,600 cases of @entity6767 in the United States at a cost of  53,000 per case. A 55% reduction in length of stay corresponds to  396 million in annual savings for the treatment of @entity6767 . Development of successful combined inpatient/outpatient management programs for @entity6767 warrants further consideration. (Population Health Management 2015;18:392-397).

title: XXXX : Influence of a Combined Inpatient/Outpatient @entity284 Treatment Regimen on the Average Length of Stay of a Medicaid NICU Population.

entities_list: @entity6767 :: ('MESH:D009357', 'Disease') :: ['NAS', 'neonatal abstinence syndrome']

entities_list: @entity29908 :: ('MESH:D006556', 'Disease') :: ['heroin abuse']

entities_list: @entity4784 :: ('MESH:D009293', 'Disease') :: ['opioid abuse', 'opioid dependence']

entities_list: @entity284 :: ('MESH:D008691', 'Chemical') :: ['methadone']

answer: @entity6767 :: (MESH:D009357,Disease) :: ['Neonatal Abstinence Syndrome']


abstract: UNASSIGNED: Prescription opioid and @entity29908 have been increasing steadily year after year, and continue to be a serious national problem. A sequela of the increase in @entity4784 has been an increase in the number of @entity1 born with @entity4784 . These @entity1 often require costly, prolonged stays in the neonatal intensive care unit (NICU) for drug withdrawal treatment. The authors studied a population of @entity1 from a large Medicaid health plan who were born with @entity6767 ( @entity6767 ) secondary to in utero opioid exposure to assess the average length of stay in the NICU, and to determine the variables that may account for differences in interinstitutional lengths of stay. The overall average length of stay for @entity6767 was 21.1 days for the 139 @entity1 included in the study. Analysis of the medication used for treatment revealed that @entity1 who were treated with a combined inpatient/outpatient regimen with @entity284 had an average length of stay of 11.4 days versus 25.1 days for @entity1 who were treated entirely as inpatients (P<0.001), a 55% reduction in average length of stay. In 2009 there were an estimated 13,600 cases of @entity6767 in the United States at a cost of  53,000 per case. A 55% reduction in length of stay corresponds to  396 million in annual savings for the treatment of @entity6767 . Development of successful combined inpatient/outpatient management programs for @entity6767 warrants further consideration. (Population Health Management 2015;18:392-397).

title: @entity6767 : Influence of a Combined Inpatient/Outpatient XXXX Treatment Regimen on the Average Length of Stay of a Medicaid NICU Population.

answer: @entity284 :: (MESH:D008691,Chemical) :: ['Methadone']


abstract: PURPOSE: @entity10931 ( @entity10931 ) is a transitory, short-lasting @entity16 characterized by a sudden onset of antero- and retrograde @entity2730 . Perfusion abnormalities in @entity10931 have been evaluated mainly by use of positron emission tomography (PET) or single-photon emission computed tomography (SPECT). In the present study we explore the value of dynamic susceptibility contrast perfusion-weighted MRI (PWI) in @entity10931 in the acute phase. METHODS: From a MRI report database we identified @entity10931 @entity1 who underwent MRI including PWI in the acute phase and compared these to control subjects. Quantitative perfusion maps (cerebral blood flow (CBF) and volume (CBV)) were generated and analyzed by use of Signal Processing In NMR-Software (SPIN). CBF and CBV values in subcortical brain regions were assessed by use of VOI created in FIRST, a model-based segmentation tool in the Oxford Centre for Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL). RESULTS: Five @entity10931 @entity1 were included (2 @entity1 , 3 @entity1 ). On PWI, no relevant perfusion alterations were found by visual inspection in @entity10931 @entity1 . Group comparisons for possible differences between @entity10931 @entity1 and control subjects showed significant lower rCBF values bilaterally in the hippocampus, in the left thalamus and globus pallidus as well as bilaterally in the putamen and the left caudate nucleus. Correspondingly, significant lower rCBV values were observed bilaterally in the hippocampus and the putamen as well as in the left caudate nucleus. Group comparisons for possible side differences in rCBF and rCBV values in @entity10931 @entity1 revealed a significant lower rCBV value in the left caudate nucleus. CONCLUSIONS: Mere visual inspection of PWI is not sufficient for the assessment of perfusion changes in @entity10931 in the acute phase. Group comparisons with healthy control subjects might be useful to detect subtle perfusion changes on PWI in @entity10931 @entity1 . However, this should be confirmed in larger data sets and serial PWI examinations.

title: Value of Dynamic Susceptibility Contrast Perfusion MRI in the Acute Phase of Transient XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity10931 :: ('MESH:D020236', 'Disease') :: ['Transient global amnesia', 'TGA']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorder']

answer: @entity2730 :: (MESH:D000647,Disease) :: ['Global Amnesia']


abstract: BACKGROUND: In case of a loss of response to adalimumab, some @entity1 with @entity30 may derive benefit from increasing the dosing frequency to 40 mg weekly. Efficacy and safety of adalimumab 80 mg weekly remain unknown. METHODS: From February 2011 to September 2012, all adults who had active @entity30 , defined at least by @entity30 activity index >150 and 1 objective sign of @entity32 , and required an adalimumab dose escalation to 80 mg weekly were enrolled in a prospective multicenter cohort study. @entity30 activity index and @entity1851 levels were recorded during the first 14 weeks following adalimumab optimization and at 6 months. All adverse events were recorded. RESULTS: Forty-two @entity1 were included. The median age was 33 years, and the median disease duration was 8.6 years. Adalimumab was associated with @entity230 in 28% of cases and with immunomodulators in 10% of @entity1 . Within the 14 weeks after adalimumab optimization, 14 @entity1 (33.3%) achieved clinical remission ( @entity30 activity index <150), and 23 @entity1 (54.8%) had a clinical response. Clinical improvement was associated with a drop in the @entity1851 level from 18 to 5 mg/L (P = 0.0008). After a median follow-up of 14.5 months, 5 @entity1 underwent major abdominal surgery. Adverse events were reported in 13 @entity1 (31%). CONCLUSIONS: Adalimumab 80 mg weekly seems to be well-tolerated and may be effective in inducing clinical remission in @entity1 with luminal @entity30 who failed to respond to 40 mg weekly or 80 mg every other week.

title: Efficacy and Safety of Adalimumab 80 mg Weekly in Luminal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity30 :: (MESH:D003424,Disease) :: ['Crohn's Disease']


abstract: The relative fibrinogenolytic, fibrinolytic and thrombolytic properties of @entity1 @entity1456 and @entity1 urokinase were compared in purified systems, in whole @entity1 plasma and in a system composed of a radioactive @entity1 blood clot (125I-fibrinogen) hanging in circulating @entity1 plasma. The @entity1 @entity1456 was highly purified from the culture fluid of a @entity1 @entity320 cell line. In purified systems composed of fibrinogen of fibrin, plasminogen and alpha 2-antiplasmin as well as in whole plasma, @entity1456 digested fibrin without degrading fibrinogen significantly. Urokinase did not have this specific fibrinolytic effect. In the circulating plasma system, the degree of fibrinolysis was proportional to the amount of activator added, @entity1456 being about 10 times more efficient than urokinase. In addition, @entity1456 appeared to cause negligible fibrinogen degradation. @entity1456 still induced significant thrombolysis at a concentration of 10 IU per ml whereas no effect of urokinase was observed at 20 IU per ml. Infusion of 100 IU (1 microgram) of @entity1456 per ml resulted in moderate activation of the fibrinolytic system as judged from a decrease of plasminogen and alpha 2-antiplasmin to 40-50 percent. Nevertheless, extensive fibrinolysis (50 to 80 percent of radioactivity released after 12 hrs) and only very limited fibrinogenolysis were observed. An equivalent amount of urokinase (100 IU per ml) only induced approximately 15 percent lysis in 12 hrs. At higher concentrations of urokinase (260 IU per ml or more) extensive activation of the fibrinolytic system was obtained as evidenced by a depletion of plasminogen, alpha 2-antiplasmin and fibrinogen. This was associated with extensive fibrinolysis (approximately 60 percent after 12 hrs). It is concluded that @entity1 @entity1456 is a more specific and effective fibrinolytic-thrombolytic agent than @entity1 urokinase.

title: Comparison of the relative fibrinogenolytic, fibrinolytic and thrombolytic properties of XXXX and urokinase in vitro.

entities_list: @entity1456 :: ('100128998', 'Gene') :: ['tissue plasminogen activator', 'Tissue plasminogen activator']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity1456 :: (100128998,Gene) :: ['tissue plasminogen activator']


abstract: The role of DNA repair genes (uvrA, uvrB, uvrD, recA, recB, @entity6899 , and umuC) in spontaneous mutation rate per bacterium per cell division (micro) was determined for the reversion of UAA (his-4 and trpE65), UAG (lacZ53), and frameshift (trpE9777) mutations, and for the occurrence of forward mutations to @entity4857 resistance. Rich growth medium enhanced micro in a wildtype strain but not in a uvrB5 strain. In minimal growth medium, the uvrA and uvrB strains had the largest micro (1.9-6.2-fold greater than that for isogenic wild-type strains, depending on the mutation assay). The uvrB strains carrying @entity6899 , recA, umuC, or both the uvrD and rec B mutations (in combination), i.e., mutations that inhibit error-prone DNA repair, had the lowest micro values (approximately 10-fold less than the uvrB strain). Teh recA and @entity6899 mutations also reduced micro (by approximately 2-fold) in uvr+ strains. The genetic control of the error prone repair-dependent sector of spontaneous mutagenesis was shown to be qualitatively similar to the genetic control for u.v. radiation mutagenesis. The umuC mutation, which drastically reduced spontaneous mutagensis, had no effect on genetic recombination. It is proposed that the low level of spontaneous mutagenesis observed in the recA, @entity6899 , umuC, and the uvrD recB strains is due to errors made during DNA replication, while the enhanced level of spontaneous mutagenesis observed in the wild type, and especially in the uvrA and uvrB strains, is due to excisable lesions that are produced in the DNA by normal metabolic reactions, and that such unexcised lesions induce mutations via error-prone DNA repair. These results are discussed in terms of their relevance to spontaneous @entity105 .

title: Much of spontaneous mutagenesis in Escherichia coli is due to error-prone DNA repair: implications for spontaneous XXXX .

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

answer: @entity105 :: (MESH:D063646,Disease) :: ['carcinogenesis']


abstract: This study was carried out to find the prevalence of precipitin reactions in the sera of 200 North American @entity748 subjects. Precipitins were detected by the double diffusion technique using different extracts of @entity54 , including a reference 'home produced' extract and five commercial extracts from three different suppliers. In addition, antigenicity of these extracts was assessed by crossed immunoelectrophoresis (XIE). Of the sera, 13.5% reacted to the reference extract and from 2.5 to 12% to the different commercial extracts; 22.5% of the sera reacted to at least one extract. No one serum reacted to all the extracts. Two of fifty-one (4%) nonatopic @entity1 with a negative immediate prick test to A. fumigatus, six of eighty-seven (6.9%) @entity1097 @entity1 with a negative immediate reaction to A. fumigatus, and thirty-seven of sixty two (59%) @entity1097 @entity1 with a positive immediate reaction to A. fumigatus had precipitins to at least one of the extracts used, the skin tests being performed using the A. fumigatus reference extract. The prevalence of precipitin reactions bore a strong correlation with the antigenicity of the extracts by XIE. The same reference extract was also used for specific IgE measurements (Brompton extract, Malo _ Paquin, 1979). It was found that @entity1 with precipitins had significantly (P less than 0.001) higher specific and total IgE values than @entity1 without precipitins. In the group of @entity1 with positive skin test, those with precipitins had significantly (P less than 0.05) higher specific IgE values than those without. The authors conclude that different extracts of A. fumigatus should be used to assess the presence of precipitins. The antigenicity of these extracts should also be assayed.

title: Prevalence of precipitating antibodies to different extracts of XXXX in a North American @entity748 population.

entities_list: @entity748 :: ('MESH:D013224', 'Disease') :: ['asthmatic']

entities_list: @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus']

answer: @entity54 :: (746128,Species) :: ['Aspergillus fumigatus']


abstract: This study was carried out to find the prevalence of precipitin reactions in the sera of 200 North American @entity748 subjects. Precipitins were detected by the double diffusion technique using different extracts of @entity54 , including a reference 'home produced' extract and five commercial extracts from three different suppliers. In addition, antigenicity of these extracts was assessed by crossed immunoelectrophoresis (XIE). Of the sera, 13.5% reacted to the reference extract and from 2.5 to 12% to the different commercial extracts; 22.5% of the sera reacted to at least one extract. No one serum reacted to all the extracts. Two of fifty-one (4%) nonatopic @entity1 with a negative immediate prick test to A. fumigatus, six of eighty-seven (6.9%) @entity1097 @entity1 with a negative immediate reaction to A. fumigatus, and thirty-seven of sixty two (59%) @entity1097 @entity1 with a positive immediate reaction to A. fumigatus had precipitins to at least one of the extracts used, the skin tests being performed using the A. fumigatus reference extract. The prevalence of precipitin reactions bore a strong correlation with the antigenicity of the extracts by XIE. The same reference extract was also used for specific IgE measurements (Brompton extract, Malo _ Paquin, 1979). It was found that @entity1 with precipitins had significantly (P less than 0.001) higher specific and total IgE values than @entity1 without precipitins. In the group of @entity1 with positive skin test, those with precipitins had significantly (P less than 0.05) higher specific IgE values than those without. The authors conclude that different extracts of A. fumigatus should be used to assess the presence of precipitins. The antigenicity of these extracts should also be assayed.

title: Prevalence of precipitating antibodies to different extracts of @entity54 in a North American XXXX population.

answer: @entity748 :: (MESH:D013224,Disease) :: ['asthmatic']


abstract: A study is reported of @entity1 receiving 180 renal allotransplants and at risk for 1 or more years who had pretransplant and posttransplant skin tests using @entity56 ( @entity56 ) recall antigens. Pretransplant skin testing revealed an incidence of 14% anergic @entity1 prior to a first transplant, and 35% were anergic prior to a second allograft. There was a statistically significant correlation between pretransplant anergy and age, as well as a significant correlation between pretransplant anergy and time of dialysis-dependent @entity5507 . The conversion to the anegic state posttransplant in those @entity1 with surviving allografts increased annually for the first 5 years as a linear function, with 69% of the population at risk with their first transplant exhibiting anergy by 5 years. In those @entity1 receiving second renal transplants, all were anergic by 4 years posttransplant. In vitro tests of lymphocyte function using mitogen stimulation did not reveal significant differences between anergic and responsive @entity1 . In this series of 180 allografts there were 14 late deaths. Eleven of these were in anergic @entity1 and in 10 instances were related to @entity295 or @entity5 . Three @entity1 who were skin-test responsive at the time of @entity204 died from cardiovascular causes. It is concluded that there is an increasing risk of the development of anergy to @entity56 antigens posttransplant and that the type of late mortality may be marked by this hyporeactive state.

title: Development of anergy to XXXX antigens following renal allotransplantation.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['delayed type hypersensitivity', 'DTH']

answer: @entity56 :: (MESH:D004342,Disease) :: ['delayed-type hypersensitivity']


abstract: This study was to examine the effects of @entity308 in @entity157 @entity1 undergoing @entity3375 . A quasiexperimental study design was used. @entity1 were evaluated at five time points: before treatment (T1) and 2, 3, 4, and 5 days after treating @entity3375 (T2, T3, T4, and T5). Fatigue and @entity308 were assessed by a VAS @entity1295 scale and a VAS @entity308 scale at each time point. TFRS and BDI were administered at T1 and T5. @entity1 ' @entity1295 and @entity308 were significantly higher at T5 than at T1 in two groups. Fatigue and @entity308 increased in both the experimental and control groups' @entity1 over the five days of hospitalization during which @entity3375 and chemotherapy were administered. The experimental group had significantly less @entity1295 than the control group, with lower subscale scores on physical, psychosocial, daily, and overall @entity1295 . There were no differences between the groups on @entity308 . At posttest, the experimental group experienced lower physical, psychosocial, daily, and overall @entity1295 than the control group. Acupressure can improve @entity1295 in @entity157 @entity1 during treatment with @entity3375 but did not alleviate @entity308 . Discharge planning should include home care for management of @entity1295 and @entity308 .

title: Effects of acupressure on fatigue and XXXX @entity1 treated with transcatheter arterial chemoembolization: a quasi-experimental study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'acupressure on fatigue and depression']

answer: @entity157 :: (MESH:D006528,Disease) :: ['depression in hepatocellular carcinoma']


abstract: This study was to examine the effects of @entity308 in @entity157 @entity1 undergoing @entity3375 . A quasiexperimental study design was used. @entity1 were evaluated at five time points: before treatment (T1) and 2, 3, 4, and 5 days after treating @entity3375 (T2, T3, T4, and T5). Fatigue and @entity308 were assessed by a VAS @entity1295 scale and a VAS @entity308 scale at each time point. TFRS and BDI were administered at T1 and T5. @entity1 ' @entity1295 and @entity308 were significantly higher at T5 than at T1 in two groups. Fatigue and @entity308 increased in both the experimental and control groups' @entity1 over the five days of hospitalization during which @entity3375 and chemotherapy were administered. The experimental group had significantly less @entity1295 than the control group, with lower subscale scores on physical, psychosocial, daily, and overall @entity1295 . There were no differences between the groups on @entity308 . At posttest, the experimental group experienced lower physical, psychosocial, daily, and overall @entity1295 than the control group. Acupressure can improve @entity1295 in @entity157 @entity1 during treatment with @entity3375 but did not alleviate @entity308 . Discharge planning should include home care for management of @entity1295 and @entity308 .

title: Effects of acupressure on fatigue and @entity157 XXXX treated with transcatheter arterial chemoembolization: a quasi-experimental study.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: @entity1071 ( @entity1071 ) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as @entity3446 have been explored. METHODS: A detailed retrospective analysis was performed according to data collected from 13 @entity1 with @entity1071 . At the time of @entity1071 diagnosis, immunosuppressive therapy was decreased and @entity3446 administered. Overall survival, disease-free survival of @entity1 and graft survival were determined. RESULTS: Among 590 kidney transplant recipients, 13 adult @entity1 with @entity1071 were included in this study. The mean age of the @entity1 was 42.15 (range: 25-58) years at the time of @entity1071 diagnosis, and 9 @entity1 were male. Histology was distributed in 9 diffuse large B cell, 1 @entity706 , 1 @entity1071 . The response rate to @entity3446 alone was 30.8%. The mean overall survival period was 23.38 months and 11 @entity1 are still alive. In total, 10 @entity1 (76.9%) achieved a complete remission with functioning graft in 11 (84.6%) @entity1 . CONCLUSION: Despite the retrospective focus and limited number of @entity1 , this study provides promising results regarding the effectiveness of stopping calcineurin inhibitors and switching to @entity3446 for @entity1 with @entity1071 .

title: Outcome of @entity3446 therapy for XXXX after kidney transplantation: case series.

entities_list: @entity3446 :: ('MESH:D020123', 'Chemical') :: ['rapamycin']

entities_list: @entity1071 :: ('MESH:D008232', 'Disease') :: ['Post-transplant lymphoproliferative disorders', 'Burkitt lymphoma, 2 Hodgkin-like PTLD', 'PTLD']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['Malt lymphoma']

answer: @entity1071 :: (MESH:D008232,Disease) :: ['post-transplant-lymphoproliferative disorder']


abstract: BACKGROUND: @entity1071 ( @entity1071 ) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as @entity3446 have been explored. METHODS: A detailed retrospective analysis was performed according to data collected from 13 @entity1 with @entity1071 . At the time of @entity1071 diagnosis, immunosuppressive therapy was decreased and @entity3446 administered. Overall survival, disease-free survival of @entity1 and graft survival were determined. RESULTS: Among 590 kidney transplant recipients, 13 adult @entity1 with @entity1071 were included in this study. The mean age of the @entity1 was 42.15 (range: 25-58) years at the time of @entity1071 diagnosis, and 9 @entity1 were male. Histology was distributed in 9 diffuse large B cell, 1 @entity706 , 1 @entity1071 . The response rate to @entity3446 alone was 30.8%. The mean overall survival period was 23.38 months and 11 @entity1 are still alive. In total, 10 @entity1 (76.9%) achieved a complete remission with functioning graft in 11 (84.6%) @entity1 . CONCLUSION: Despite the retrospective focus and limited number of @entity1 , this study provides promising results regarding the effectiveness of stopping calcineurin inhibitors and switching to @entity3446 for @entity1 with @entity1071 .

title: Outcome of XXXX therapy for @entity1071 after kidney transplantation: case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity3446 :: (MESH:D020123,Chemical) :: ['rapamycin']


abstract: The ability to predict protein function from structure is becoming increasingly important; hence, elucidation and determination of protein structure become the major steps in proteomics. The present study was undertaken for identification of metalloprotease produced by @entity5259 B80 and recognition of characteristics that can be industrially exploited. The enzyme was purified in three steps combining precipitation and chromatographic methods resulting in 33.5% recovery with 13.1-fold purification of enzyme which was detected as a single band with a molecular mass of 26   kDa approximately in @entity214 -PAGE and zymogram. The @entity215 showed that the enzyme exhibited 70-93% similarity with @entity219 metalloproteases from various strains Bacillus sp. specifically from @entity5259 group. The sequence alignment revealed the presence of @entity219 -binding region VVVHEMCHMV in the most conserved C terminus region. Secondary structure of the enzyme was obtained by CD spectra and I-TASSER. The enzyme kinetics revealed a Michaelis constant (K m ) of 0.140    mol/ml and V max of 2.11    mol/min. The application studies showed that the enzyme was able to hydrolyze various proteins with highest affinity towards casein followed by BSA and gelatin. The enzyme exhibited strong fibrinolytic, collagenolytic, and gelatinolytic properties and stability in various organic solvents.

title: XXXX and CD Spectral Analysis for Identification and Structure Prediction of a Purified, Novel, Organic Solvent Stable, Fibrinolytic Metalloprotease from @entity5259 B80.

entities_list: @entity5259 :: ('1396', 'Species') :: ['Bacillus cereus']

entities_list: @entity215 :: ('MESH:D013771', 'Disease') :: ['MALDI-TOF MS']

answer: @entity215 :: (MESH:D013771,Disease) :: ['MALDI-TOF MS']