abstract: BACKGROUND: Prevention of secondary @entity1545 is a key component of acute management of @entity1 with severe @entity131 ( @entity131 ). Haemoglobin concentration may have an impact on optimization of cerebral oxygenation. @entity1 with @entity131 may best be served by an organized @entity130 service. The objective is to determine if haemoglobin concentration or dedicated @entity130 admission has an impact on outcomes after severe @entity131 . METHODS: This study retrospectively analysed consecutive @entity1 with severe @entity131 admitted to a level-I @entity130 centre over 3 years. @entity1 <16 years-old and with length of stay (LOS) <24 hours were excluded. Data were collected on demographics; injury severity; LOS; admission service; survival to discharge; and haemoglobin levels from hospital days 1-7. Data were also collected on number of transfusions of packed red blood cells. The sample was stratified based on admission service and survival to discharge. RESULTS: Of 147 @entity1 (age   =   54.1        3.7 years), overall mortality rate was 15.4% (n   =   23). Overall, non-survivors had lower daily and 7-day mean haemoglobin levels (10.7        0.9 vs. 12.9        0.4   g   dL(-1), p   <   0.001). Non-surgical admissions had lower haemoglobin levels and a higher mortality rate (28.9% vs. 12.2%, p   <   0.001) compared to dedicated @entity130 admissions. CONCLUSIONS: Among @entity1 with severe @entity131 , higher haemoglobin levels and maintenance as a dedicated @entity130 admission are associated with higher survival to discharge.

title: Higher haemoglobin levels and dedicated XXXX admission are associated with survival after severe @entity131 .

answer: @entity130 :: (MESH:D014947,Disease) :: ['trauma']


abstract: UNASSIGNED: @entity146 ( @entity146 ) is one of the natural mechanisms of @entity5157 for limiting the spread of @entity66 and @entity31860 parasitic mite. Objective of our study was to measure @entity146 of @entity5157 unicolor colonies (N = 403) from three geographic regions (one infested and two free of @entity31860 ) in Madagascar. The pin-killing method was used for evaluation of the @entity146 . Responses were measured from 3 h 30 min to 7 h after perforation of the cells. Colonies were very effective in detecting perforated cells. In the first 4 h, on average, they detected at least 50% of the pin-killed brood. Six hours after cell perforation, colonies tested (N = 91) showed a wide range of uncapped (0 to 100%) and cleaned cells (0 to 82%). Global distribution of the rate of cleaned cells at 6 h was multimodal and @entity10281 responses could be split in three classes. Colonies from the three regions showed a significant difference in @entity146 responses. Three hypotheses (geographic, genetic traits, presence of @entity31860 ) are further discussed to explain variability of @entity146 responses among the regions. Levels of @entity146 efficiency of A. mellifera unicolor colonies are among the greatest levels reported for A. mellifera subspecies. Presence of highly @entity10281 colonies is a great opportunity for future breeding program in selection for @entity146 .

title: Assessing @entity10281 behavior of XXXX unicolor (Hymenoptera: Apidae), the endemic @entity5157 from Madagascar.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['brood diseases']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['HB', 'Hygienic behavior']

entities_list: @entity5157 :: ('7460', 'Species') :: ['honey bee', 'Apis mellifera']

entities_list: @entity31860 :: ('109461', 'Species') :: ['Varroa destructor', 'V. destructor']

answer: @entity5157 :: (7460,Species) :: ['Apis mellifera']


abstract: UNASSIGNED: @entity146 ( @entity146 ) is one of the natural mechanisms of @entity5157 for limiting the spread of @entity66 and @entity31860 parasitic mite. Objective of our study was to measure @entity146 of @entity5157 unicolor colonies (N = 403) from three geographic regions (one infested and two free of @entity31860 ) in Madagascar. The pin-killing method was used for evaluation of the @entity146 . Responses were measured from 3 h 30 min to 7 h after perforation of the cells. Colonies were very effective in detecting perforated cells. In the first 4 h, on average, they detected at least 50% of the pin-killed brood. Six hours after cell perforation, colonies tested (N = 91) showed a wide range of uncapped (0 to 100%) and cleaned cells (0 to 82%). Global distribution of the rate of cleaned cells at 6 h was multimodal and @entity10281 responses could be split in three classes. Colonies from the three regions showed a significant difference in @entity146 responses. Three hypotheses (geographic, genetic traits, presence of @entity31860 ) are further discussed to explain variability of @entity146 responses among the regions. Levels of @entity146 efficiency of A. mellifera unicolor colonies are among the greatest levels reported for A. mellifera subspecies. Presence of highly @entity10281 colonies is a great opportunity for future breeding program in selection for @entity146 .

title: Assessing @entity10281 behavior of @entity5157 unicolor (Hymenoptera: Apidae), the endemic XXXX from Madagascar.

answer: @entity5157 :: (7460,Species) :: ['honey bee']


abstract: UNASSIGNED: @entity146 ( @entity146 ) is one of the natural mechanisms of @entity5157 for limiting the spread of @entity66 and @entity31860 parasitic mite. Objective of our study was to measure @entity146 of @entity5157 unicolor colonies (N = 403) from three geographic regions (one infested and two free of @entity31860 ) in Madagascar. The pin-killing method was used for evaluation of the @entity146 . Responses were measured from 3 h 30 min to 7 h after perforation of the cells. Colonies were very effective in detecting perforated cells. In the first 4 h, on average, they detected at least 50% of the pin-killed brood. Six hours after cell perforation, colonies tested (N = 91) showed a wide range of uncapped (0 to 100%) and cleaned cells (0 to 82%). Global distribution of the rate of cleaned cells at 6 h was multimodal and @entity10281 responses could be split in three classes. Colonies from the three regions showed a significant difference in @entity146 responses. Three hypotheses (geographic, genetic traits, presence of @entity31860 ) are further discussed to explain variability of @entity146 responses among the regions. Levels of @entity146 efficiency of A. mellifera unicolor colonies are among the greatest levels reported for A. mellifera subspecies. Presence of highly @entity10281 colonies is a great opportunity for future breeding program in selection for @entity146 .

title: Assessing XXXX behavior of @entity5157 unicolor (Hymenoptera: Apidae), the endemic @entity5157 from Madagascar.

answer: @entity10281 :: (MESH:D020920,Disease) :: ['hygienic']


abstract: BACKGROUND: Aggressive anti- @entity5 treatments can result in @entity2670 . Ovarian cryopreservation has been developed to preserve the fertility of young @entity1 , but early graft revascularisation still requires improvement. METHODS: Frozen/thawed @entity742 ovarian cortical biopsies were embedded in collagen matrix with or without isoform 165 of vascular endothelial growth factor ( @entity1655 ) and transplanted into ovaries of @entity465 @entity19 . Ovaries were chosen as transplantation sites to more closely resemble clinical conditions in which orthotopic transplantation has previously allowed several spontaneous pregnancies. RESULTS: We found that @entity1655 significantly increased the number of Dextran- @entity2823 positive functional vessels 3  days after grafting. Dextran- @entity2822 ( @entity2823 ) positive vessels were detectable in 53% and 29% of the @entity19 in the @entity1611 -treated and control groups, respectively. Among these positive fragments, 50% in the treated group displayed mature smooth-muscle-actin-alpha (alpha-SMA) positive functional vessels compared with 0% in the control group. @entity5231 positive @entity19 blood vessels were observed in 40% of the @entity1655 transplants compared with 21% of the controls. After 3  weeks, the density of @entity19 vessels was significantly higher in the @entity1655 group. CONCLUSION: The encapsulation of ovarian tissue in collagen matrix in the presence of @entity1655 before grafting has a positive effect on functional blood vessel recruitment. It can be considered as a useful technique to be improved and further developed before @entity1 clinical applications in female @entity5 @entity1 in the context of fertility preservation.

title: Isoform 165 of vascular endothelial growth factor in collagen matrix improves ovine cryopreserved ovarian tissue revascularisation after xenotransplantation in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'human', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2822 :: ('CHEBI:37926', 'Chemical') :: ['fluorescein isothiocyanate']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficient']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['ovarian failure']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: UNASSIGNED: We explored the immunomodulatory effects of bone marrow mesenchymal stem cells (BMSCs) on peripheral blood T lym-phocytes in @entity1 with decompensation stage, @entity1956 -associated @entity82 . MSCs from nine @entity1 were analyzed by flow cytometry. Peripheral blood lymphocytes were isolated for fluorescent staining. Following stimulation by phytohemagglutinin (PHA), peripheral blood lymphocytes were co-cultured with BMSCs in serum and divided into four groups: (1) BMSC + lymphocyte + PHA contact culture group; (2) BMSC + lymphocyte + PHA non-contact culture group; (3) lym-phocyte + PHA positive control group; and (4) lymphocyte-only negative control group. Lymphocyte proliferation and frequencies of @entity404 (+)CD25(+)CD127(-) Tregs and @entity404 (+) @entity405 (-)IL-17(+) (Th17) cells were de-tected. Cell proliferation in groups 1 and 2 declined compared with group 3 (P < 0.01), and was notably higher than in group 4 (P < 0.01). @entity404 (+)CD25(+)CD127(-) Tregs frequencies in groups 1 and 2 were higher than in groups 3 and 4. In an intra-group comparison before and after culture, Th17 cell frequencies in groups 1 and 2 were higher than in group 4 (P < 0.01), but lower than in group 3 (P < 0.01). The Treg/Th17 ratio in groups 1 and 2 increased (P < 0.01), but did not change signifi-cantly in groups 3 and 4 (P > 0.05). In a comparison between groups after culture, the Treg/Th17 ratio in groups 1 and 2 increased more than in groups 3 and 4 (P < 0.01). BMSCs from cirrhotic @entity1 can inhibit the proliferation of peripheral blood T lymphocytes, upregulate the ex-pression of @entity404 (+)CD25(+)CD127(-) Tregs, and improve Treg/Th17 imbal-ance. The mechanism by which this takes place may be associated with immunomodulatory effects induced by the secretion of soluble factors.

title: Immunomodulatory effect of bone marrow mesenchymal stem cells on T lymphocytes in XXXX with decompensated liver cirrhosis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: The clinical presentation and results of management of septic @entity2268 in 35 @entity1 over a seven-year period are reviewed. There were 25 @entity1 and ten @entity1 ; 20 @entity1 were over age 50. At diagnosis, @entity221 was present in 33 @entity1 (94%), and 33 (94%) had local signs of @entity32 . Pus was expressed from the infusion site in 25 @entity1 (71%). All @entity1 had plastic catheters, with 95% present longer than 48 hours. Klebsiella-Enterobacter was the dominant organism both at the infusion site and in the blood. All @entity1 had surgical excision of the infected vein, followed in 60% by rapid lysis of @entity221 . Other @entity281 were responsible for persistent @entity221 after total excision. @entity2268 is best prevented by strict asepsis in catheter placement and rotation of infusion sites every 48 hours. Total excision of the infected vein remains the treatment of choice.

title: Catheter-associated septic XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity2268 :: ('MESH:D013924', 'Disease') :: ['thrombophlebitis', 'Septic thrombophlebitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

answer: @entity2268 :: (MESH:D013924,Disease) :: ['thrombophlebitis']


abstract: BACKGROUND: Previous research has shown that electroacupuncture therapy has a potential therapeutic effect for simple female stress urinary @entity322 . In this study, pelvic floor muscle training, the first-line treatment for stress urinary @entity322 in @entity1 based on meta-analysis of numerous randomized control trials and recommended by international clinical practice, is used as a control group to demonstrate whether electroacupuncture therapy is a better method for female stress urinary @entity322 . METHODS/DESIGN: A randomized controlled trial has been designed to evaluate the therapeutic benefit of electroacupuncture for female stress urinary @entity322 compared with pelvic floor muscle training. The safety of electroacupuncture and @entity1 compliance will also be evaluated. Untoward reaction to the electroacupuncture, including a broken needle, fainting on acupuncture, or @entity158 during acupuncture, will be recorded and the therapy will be stopped if an untoward reaction occurs. After we have received full ethical approval and @entity1 consent, @entity1 will be randomized to receive a series of 24 electroacupuncture or pelvic floor muscle training interventions. The frequency and amount of leakage will be measured as the primary outcome parameters. Secondary outcome parameters include the 1-hour pad test, the short-form of the International Consultation on Incontinence Questionnaire, @entity1 subjective effectiveness evaluation, weekly usage of pad, and usage of specialty therapy for female stress urinary @entity322 . DISCUSSION: This trial will help to determine whether electroacupuncture is a more effective treatment than pelvic floor muscle training for @entity1 with female stress urinary @entity322 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01940432 (12 September 2013).

title: The efficacy of electroacupuncture for the treatment of simple female stress urinary XXXX - comparison with pelvic floor muscle training: study protocol for a multicenter randomized controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'patients', 'patient']

entities_list: @entity322 :: ('MESH:D014549', 'Disease') :: ['incontinence']

answer: @entity322 :: (MESH:D014549,Disease) :: ['incontinence']


abstract: PURPOSE: To evaluate the incidence of @entity323 ( @entity323 ) and recoverability of erectile function (EF) after anastomotic urethroplasty for traumatic urethral injuries (TUIs) of different etiologies. METHODS: A retrospective review for @entity1 ' records underwent perineal anastomotic urethroplasty for TUIs from June 1998 to January 2014 was conducted. Those @entity1 were contacted and evaluated using the International Index of erectile function questionnaire in sexually active @entity1 , and in unmarried @entity1 , the single-question self-report of @entity323 was used. @entity1 with @entity323 underwent penile color Doppler ultrasonography. RESULTS: Overall, 81 @entity1 were included in the study. The incidences of @entity323 following urethroplasty for TUIs were 72.3, 35.3 and 0  % in cases due to @entity174 , straddle and iatrogenic injuries, respectively. None of the @entity1 reported deterioration of EF after urethroplasty. Seven (13.5  %) @entity1 reported recovery of their EF within 2  years after @entity130 . The probability of recovery of EF after PFUI was 9  % compared to 28.6 and 100  % in @entity1 with straddle and iatrogenic urethral injuries, respectively. @entity1 with type C @entity174 had no chance for EF recoverability. CONCLUSIONS: PFUIs have a probability of causing @entity323 as much as 72  % compared to 35 and 0  % in @entity1 with straddle and iatrogenic urethral injuries, respectively. Anastomotic urethroplasty has no deleterious effect on EF. A tendency for higher recoverability of EF could be observed after iatrogenic urethral injuries followed by straddle injury then PFUIs. The probability of recovery decreased proportionally with severity of @entity530 .

title: XXXX post-perineal anastomotic urethroplasty for traumatic urethral injuries: analysis of incidence and possibility of recovery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men']

entities_list: @entity323 :: ('MESH:D007172', 'Disease') :: ['erectile dysfunction', 'ED']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['pelvic fracture']

entities_list: @entity530 :: ('MESH:D010386', 'Disease') :: ['pelvic trauma']

answer: @entity323 :: (MESH:D007172,Disease) :: ['Erectile dysfunction']


abstract: BACKGROUND: Myalgic @entity5815 (ME/CFS) is a disease of unknown etiology. We previously reported a pilot case series followed by a small, randomized, placebo-controlled phase II study, suggesting that B-cell depletion using the monoclonal anti- @entity2225 antibody rituximab can yield clinical benefit in ME/CFS. METHODS: In this single-center, open-label, one-armed phase II study (NCT01156909), 29 @entity1 were included for treatment with @entity2408 (500 mg/m2) two infusions two weeks apart, followed by maintenance rituximab infusions after 3, 6, 10 and 15 months, and with follow-up for 36 months. FINDINGS: Major or moderate responses, predefined as lasting improvements in self-reported Fatigue score, were detected in 18 out of 29 @entity1 (intention to treat). Clinically significant responses were seen in 18 out of 28 @entity1 (64%) receiving rituximab maintenance treatment. For these 18 @entity1 , the mean response durations within the 156 weeks study period were 105 weeks in 14 major responders, and 69 weeks in four moderate responders. At end of follow-up (36 months), 11 out of 18 responding @entity1 were still in ongoing clinical remission. For major responders, the mean lag time from first rituximab infusion until start of clinical response was 23 weeks (range 8-66). Among the nine @entity1 from the placebo group in the previous randomized study with no significant improvement during 12 months follow-up after saline infusions, six achieved a clinical response before 12 months after rituximab maintenance infusions in the present study. Two @entity1 had an @entity56 to rituximab and two had an episode of uncomplicated late-onset @entity1398 . Eight @entity1 experienced one or more transient symptom flares after rituximab infusions. There was no unexpected @entity137 . CONCLUSION: In a subgroup of ME/CFS @entity1 , prolonged B-cell depletion with rituximab maintenance infusions was associated with sustained clinical responses. The observed patterns of delayed responses and relapse after B-cell depletion and regeneration, a three times higher disease prevalence in @entity1 than in @entity1 , and a previously demonstrated increase in @entity1892 risk for elderly ME/CFS @entity1 , suggest that ME/CFS may be a variant of an @entity792 . TRIAL REGISTRATION: ClinicalTrials.gov NCT01156909.

title: B-Lymphocyte Depletion in Myalgic Encephalopathy/ XXXX . An Open-Label Phase II Study with Rituximab Maintenance Treatment.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['B-cell lymphoma']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic reaction']

entities_list: @entity5815 :: ('MESH:D015673', 'Disease') :: ['Encephalopathy/Chronic Fatigue Syndrome']

entities_list: @entity2408 :: ('CHEBI:64357', 'Chemical') :: ['rituximab']

entities_list: @entity792 :: ('MESH:D001327', 'Disease') :: ['autoimmune disease']

answer: @entity5815 :: (MESH:D015673,Disease) :: ['Chronic Fatigue Syndrome']


abstract: BACKGROUND: The outcome of @entity1 after out-of-hospital @entity1167 (OHCA) is poor and gets worse after prolonged resuscitation. Recently introduced attempts like an early installed emergency extracorporeal life support (E-ECLS) in @entity1 with persisting @entity1167 at the @entity341 ( @entity341 ) are tried. The "Vienna Cardiac Arrest Registry" (VICAR) was introduced August 2013 to collect Utstein-style data. The aim of this observational study was to identify the incidence of @entity1 which @entity22323 "load_go"-criteria for E-ECLS at the @entity341 . METHODS: VICAR was retrospectively analyzed for following criteria: age <75 years; witnessed OHCA; basic life support; @entity2224 / @entity1165 ; no return-of-spontaneous-circulation (ROSC) within 15min of advanced-life-support, which were supposed as potential optimal criteria for "load_go" plus successful E-ECLS treatment at the @entity341 . The observation period was from August 1, 2013 to July 31, 2014. RESULTS: Over 948 OHCA @entity1 registered during the study period; data were exploitable for 864 @entity1 . Of all @entity1 , "load_go"-criteria were fulfilled by 55 (6%). However, 96 (11%) were transported with on-going CPR to the @entity341 . Of these 96 @entity1 , only 16 (17%) met the "load_go"-criteria. Similarly, among the 96 @entity1 , 12 adults were treated with E-ECLS at the @entity341 , with only 5 meeting the criteria. Among these 12 @entity1 , favourable neurological outcome (CPC 1/2) was obtained in 1 @entity1 without criteria. CONCLUSION: Further promotion of these criteria within the ambulance crews is needed. May be these criteria could serve as a decision support for emergency physicians/paramedics, which @entity1 to transport with on-going CPR to the @entity341 for E-ECLS.

title: The incidence of "load_go" out-of-hospital @entity1167 candidates for XXXX utilization of emergency extracorporeal life support: A one-year review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['ventricular tachycardia']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

answer: @entity341 :: (MESH:D004630,Disease) :: ['emergency department']


abstract: BACKGROUND: The outcome of @entity1 after out-of-hospital @entity1167 (OHCA) is poor and gets worse after prolonged resuscitation. Recently introduced attempts like an early installed emergency extracorporeal life support (E-ECLS) in @entity1 with persisting @entity1167 at the @entity341 ( @entity341 ) are tried. The "Vienna Cardiac Arrest Registry" (VICAR) was introduced August 2013 to collect Utstein-style data. The aim of this observational study was to identify the incidence of @entity1 which @entity22323 "load_go"-criteria for E-ECLS at the @entity341 . METHODS: VICAR was retrospectively analyzed for following criteria: age <75 years; witnessed OHCA; basic life support; @entity2224 / @entity1165 ; no return-of-spontaneous-circulation (ROSC) within 15min of advanced-life-support, which were supposed as potential optimal criteria for "load_go" plus successful E-ECLS treatment at the @entity341 . The observation period was from August 1, 2013 to July 31, 2014. RESULTS: Over 948 OHCA @entity1 registered during the study period; data were exploitable for 864 @entity1 . Of all @entity1 , "load_go"-criteria were fulfilled by 55 (6%). However, 96 (11%) were transported with on-going CPR to the @entity341 . Of these 96 @entity1 , only 16 (17%) met the "load_go"-criteria. Similarly, among the 96 @entity1 , 12 adults were treated with E-ECLS at the @entity341 , with only 5 meeting the criteria. Among these 12 @entity1 , favourable neurological outcome (CPC 1/2) was obtained in 1 @entity1 without criteria. CONCLUSION: Further promotion of these criteria within the ambulance crews is needed. May be these criteria could serve as a decision support for emergency physicians/paramedics, which @entity1 to transport with on-going CPR to the @entity341 for E-ECLS.

title: The incidence of "load_go" out-of-hospital XXXX candidates for @entity341 utilization of emergency extracorporeal life support: A one-year review.

answer: @entity1167 :: (MESH:D006323,Disease) :: ['cardiac arrest']


abstract: BACKGROUND: Because circulating antibodies against a variety of antigens have been detected in @entity1 with @entity301 , @entity2998 and those who have suffered a @entity64 , it is suspected that immune response may be one of the mechanisms of atherogenesis The objective of this study is to identify novel antibodies in @entity385 @entity1 by screening the expressed recombinant proteins using a @entity1 cDNA library (SEREX). METHODS: To identify the candidate antigens, cDNA library was screened by SEREX using plasma from ten @entity1 with @entity385 . Subsequently, via ELISA using recombinant proteins and synthetic peptides, the serum antibody levels were measured in two independent @entity1 /healthy donor (HD) cohorts (142 and 78 in the 2nd screening and a validation cohort, respectively). RESULTS: The initial screening resulted in the identification of six candidate antigens. Of these antigens, @entity32686 ( @entity32686 ) was determined to be the antigen associated with @entity64 (P   <   0.05) by ELISA with 2nd screening and validation cohort. Multifactorial logistic regression analysis showed that the increased levels of the @entity32686 antibodies ( @entity32686 -Abs) associated with @entity64 independent of other risk factors for @entity64 (P   <   0.05). Receiver operating curve analysis demonstrated that the area under the curve from ELISA using GST fusion @entity32686 and synthetic peptides (bRPA2-132) were 0.867 (95% CI: 0.798-0.936) and 0.971 (95% CI: 0.940-1.00), respectively. If the cut-off value of the bRPA2-132-Ab level was determined to be 0.334, the sensitivity and specificity of the antibody level as the diagnostic marker for @entity64 were 0.323 (95% CI: 0.209-0.453) and 1.00 (95% CI: 0.713-1.00), respectively. CONCLUSIONS: SEREX identified @entity32686 as the antigen associated with @entity385 and serum auto-antibodies against @entity32686 elevates in @entity64 @entity1 . @entity32686 -Abs could become a biomarker for the evaluation of @entity385 at risk.

title: Identification of XXXX -associated-antigens via screening of recombinant proteins from the @entity1 expression cDNA library (SEREX).

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity2998 :: ('MESH:D002340', 'Disease') :: ['carotid atherosclerosis']

entities_list: @entity32686 :: ('6118', 'Gene') :: ['replication protein A2', 'RPA2']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: BACKGROUND: Because circulating antibodies against a variety of antigens have been detected in @entity1 with @entity301 , @entity2998 and those who have suffered a @entity64 , it is suspected that immune response may be one of the mechanisms of atherogenesis The objective of this study is to identify novel antibodies in @entity385 @entity1 by screening the expressed recombinant proteins using a @entity1 cDNA library (SEREX). METHODS: To identify the candidate antigens, cDNA library was screened by SEREX using plasma from ten @entity1 with @entity385 . Subsequently, via ELISA using recombinant proteins and synthetic peptides, the serum antibody levels were measured in two independent @entity1 /healthy donor (HD) cohorts (142 and 78 in the 2nd screening and a validation cohort, respectively). RESULTS: The initial screening resulted in the identification of six candidate antigens. Of these antigens, @entity32686 ( @entity32686 ) was determined to be the antigen associated with @entity64 (P   <   0.05) by ELISA with 2nd screening and validation cohort. Multifactorial logistic regression analysis showed that the increased levels of the @entity32686 antibodies ( @entity32686 -Abs) associated with @entity64 independent of other risk factors for @entity64 (P   <   0.05). Receiver operating curve analysis demonstrated that the area under the curve from ELISA using GST fusion @entity32686 and synthetic peptides (bRPA2-132) were 0.867 (95% CI: 0.798-0.936) and 0.971 (95% CI: 0.940-1.00), respectively. If the cut-off value of the bRPA2-132-Ab level was determined to be 0.334, the sensitivity and specificity of the antibody level as the diagnostic marker for @entity64 were 0.323 (95% CI: 0.209-0.453) and 1.00 (95% CI: 0.713-1.00), respectively. CONCLUSIONS: SEREX identified @entity32686 as the antigen associated with @entity385 and serum auto-antibodies against @entity32686 elevates in @entity64 @entity1 . @entity32686 -Abs could become a biomarker for the evaluation of @entity385 at risk.

title: Identification of @entity64 -associated-antigens via screening of recombinant proteins from the XXXX expression cDNA library (SEREX).

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity28 , @entity1007 and @entity6 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity1 ) against @entity74 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity23382 and @entity3089 ( @entity3090 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity35 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity165 diet), trial-III (high @entity969 diet), trial-IV (high @entity165   +   high @entity969 diet). @entity35 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity35 were sacrificed and evaluated their serum lipid ( @entity165 , LDL and HDL), @entity413 and insulin levels. RESULTS: Results for feed consumption by @entity35 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity165 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity413 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity3090 reduced the trait better than @entity23382 based functional drink. CONCLUSIONS: The drinks supplemented with @entity23382 and @entity3090 are effective against @entity28 , @entity1007 and @entity4854 .

title: Preventive role of green tea @entity23382 from @entity28 and @entity74 especially @entity1007 and XXXX .

entities_list: @entity1007 :: ('MESH:D006937', 'Disease') :: ['hypercholesterolemia']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity23382 :: ('CHEBI:23053', 'Chemical') :: ['catechins']

entities_list: @entity3089 :: ('MESH:C045651', 'Chemical') :: ['epigallocatechin gallate']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['lifestyle related disorders']

entities_list: @entity4854 :: ('MESH:D006943', 'Disease') :: ['hyperglycemia']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity4854 :: (MESH:D006943,Disease) :: ['hyperglycemia']


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity28 , @entity1007 and @entity6 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity1 ) against @entity74 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity23382 and @entity3089 ( @entity3090 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity35 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity165 diet), trial-III (high @entity969 diet), trial-IV (high @entity165   +   high @entity969 diet). @entity35 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity35 were sacrificed and evaluated their serum lipid ( @entity165 , LDL and HDL), @entity413 and insulin levels. RESULTS: Results for feed consumption by @entity35 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity165 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity413 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity3090 reduced the trait better than @entity23382 based functional drink. CONCLUSIONS: The drinks supplemented with @entity23382 and @entity3090 are effective against @entity28 , @entity1007 and @entity4854 .

title: Preventive role of green tea @entity23382 from @entity28 and XXXX especially @entity1007 and @entity4854 .

answer: @entity74 :: (MESH:D030342,Disease) :: ['related disorders']


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity28 , @entity1007 and @entity6 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity1 ) against @entity74 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity23382 and @entity3089 ( @entity3090 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity35 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity165 diet), trial-III (high @entity969 diet), trial-IV (high @entity165   +   high @entity969 diet). @entity35 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity35 were sacrificed and evaluated their serum lipid ( @entity165 , LDL and HDL), @entity413 and insulin levels. RESULTS: Results for feed consumption by @entity35 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity165 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity413 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity3090 reduced the trait better than @entity23382 based functional drink. CONCLUSIONS: The drinks supplemented with @entity23382 and @entity3090 are effective against @entity28 , @entity1007 and @entity4854 .

title: Preventive role of green tea @entity23382 from XXXX and @entity74 especially @entity1007 and @entity4854 .

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity28 , @entity1007 and @entity6 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity1 ) against @entity74 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity23382 and @entity3089 ( @entity3090 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity35 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity165 diet), trial-III (high @entity969 diet), trial-IV (high @entity165   +   high @entity969 diet). @entity35 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity35 were sacrificed and evaluated their serum lipid ( @entity165 , LDL and HDL), @entity413 and insulin levels. RESULTS: Results for feed consumption by @entity35 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity165 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity413 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity3090 reduced the trait better than @entity23382 based functional drink. CONCLUSIONS: The drinks supplemented with @entity23382 and @entity3090 are effective against @entity28 , @entity1007 and @entity4854 .

title: Preventive role of green tea XXXX from @entity28 and @entity74 especially @entity1007 and @entity4854 .

answer: @entity23382 :: (CHEBI:23053,Chemical) :: ['catechins']


abstract: BACKGROUND: During the last few years, scientific investigations have proposed diet based regimens to prevent several health ailments including @entity28 , @entity1007 and @entity6 . In this regard, a promising tool is the use of functional foods/nutraceuticals. Present research project was an attempt to explore nutraceutical worth of locally grown green tea variety (Qi- @entity1 ) against @entity74 . METHODS: Functional drinks (T2 and T3) were prepared by adding @entity23382 and @entity3089 ( @entity3090 ) @ 550  mg/500  mL and compared with control (T1). These functional drinks were tested in experimental @entity35 modeling (Sprague Dawley). Based on diets, four studies were conducted i.e. trial-I (normal diet), trial-II (high @entity165 diet), trial-III (high @entity969 diet), trial-IV (high @entity165   +   high @entity969 diet). @entity35 were monitored daily for their feed and drink intake while body weight was measured on weekly basis. After period of 56  days @entity35 were sacrificed and evaluated their serum lipid ( @entity165 , LDL and HDL), @entity413 and insulin levels. RESULTS: Results for feed consumption by @entity35 revealed that highest feed intake was recorded in group provided control drink than other groups. However, non significant differences were noted among all groups for drink consumption. Functional drinks resulted in significant reduction in body weight with maximum lowering noted in trial-II and III i.e. 10.73 to 8.49% and 10.12 to 10.49%, respectively. Likewise, @entity165 and LDL were substantially reduced with 14.42% decrease observed in trial-IV and 30.43% in trial-II, respectively. Furthermore, serum @entity413 and insulin levels were also lowered significantly in the trial-III and IV while in trial-I and II differences were non-significant. In contrast to lipid profile, experimental drink containing @entity3090 reduced the trait better than @entity23382 based functional drink. CONCLUSIONS: The drinks supplemented with @entity23382 and @entity3090 are effective against @entity28 , @entity1007 and @entity4854 .

title: Preventive role of green tea @entity23382 from @entity28 and @entity74 especially XXXX and @entity4854 .

answer: @entity1007 :: (MESH:D006937,Disease) :: ['hypercholesterolemia']


abstract: PURPOSE: We reviewed the @entity706 epidemiological data for the Mexico City metropolitan area (MCMA). METHODS: Data analysis from @entity1 (0-14  years old) diagnosed with @entity706 during the period 1996-2010 was performed at the Mexican @entity5 Registry. Histological subtype was determined according to the International Classification of @entity5 3 (ICCC-3). Age-adjusted incidence rates were calculated per 1,000,000 @entity1 /year by age, gender, and ICCC-3 subtype; trends, by @entity1987 ( @entity1987 ). RESULTS: A total of 328 @entity706 cases included in the study had an incidence rate of 11.8, showing a decreasing trend [ @entity1987 : -3.5; CI95% (-5.9, -1.0)], primarily due to @entity1893 ( @entity1893 ) and @entity978 ( @entity978 ) mixed cellularity subtype. @entity1893 had the major incidence (5.8), with the precursor cell subtype being the most frequent (38.3  %). @entity4383 was the most frequent @entity978 subtype. The incidence of @entity2109 was low (1.3). During the study period, there was an important reduction in the not-otherwise-specified @entity1893 , which translated into a relative increase in the IIb3 subtype [ @entity1987 : 7.3 (1.2, 13.8)]. Low incidences of @entity1893 and of @entity978 and @entity1893 were found for <1-year-olds and for 10- to 14-year-olds, respectively. Incidence rates for @entity1 in the MCMA, particularly the <1 and 10-14 age groups, were lower than those for developed countries. The overall male/female ratio was 2.3. CONCLUSIONS: There was a trend toward a reduced incidence, for some @entity706 subtypes, in particular for @entity706 , which may be the result of improvement in diagnostic techniques.

title: XXXX incidence patterns by ICCC-3 subtype in Mexico City metropolitan area population insured by Instituto Mexicano del Seguro Social, 1996-2010.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity1987 :: ('MESH:D009402', 'Disease') :: ['average annual percent change', 'AAPC']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'childhood lymphomas', 'NOS lymphomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Childhood Cancer']

entities_list: @entity2109 :: ('MESH:D002051', 'Disease') :: ['Burkitt lymphoma']

entities_list: @entity4383 :: ('MESH:D020518', 'Disease') :: ['Nodular sclerosis']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphomas', 'subtype of NHL']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ['HL', 'Hodgkin lymphoma']

answer: @entity706 :: (MESH:D008223,Disease) :: ['Childhood lymphoma']


abstract: UNASSIGNED: Chromosomal aberrations have significant prognostic importance in @entity1582 ( @entity1582 ). However, proteasome inhibitors (PI) and IMiDs may partly overcome the poor prognostic impact of some of them. In this study, we investigated a population-based consecutive cohort newly diagnosed @entity1 with @entity1582 admitted during a defined time period to hospitals in Denmark, Norway, and Sweden. The impact of treatment modality on the prognostic importance of specific chromosomal aberration was investigated, with special reference to gain 1q21. The median follow-up of @entity1 still alive at analysis was 40  months for the high-dose (HDT)-treated ones and 29  months for the whole population. Three hundred forty-seven @entity1 with a known 1q21 status were included in this study. The 347 @entity1 were divided into three groups, that is, 119 @entity1 with the 1q21 gain, 105 @entity1 with @entity2008 ( @entity2008 ), that is, del(13q), del(17p), t(4,14), and/or (14;16), and 123 @entity1 with no aberrations (NA). The groups were compared in terms of @entity1349 ( @entity1349 ), @entity1054 ( @entity1054 ), and response. The 3-yr @entity1349 for @entity1 with gain 1q21 was 60% compared to @entity1 with @entity2008 74% and NO 82% (gain 1q21 vs. NO P  <  0.001; gain 1q21 vs. @entity2008 P  =  0.095). If treated with PI or IMiDs, the 3-yr @entity1349 was 58% for @entity1 with gain 1q21 compared to @entity1 with @entity2008 78% and NO 78%, respectively (P  =  0.041, P  =  0.140). In HDT @entity1 , the 3-yr @entity1349 was 69% for @entity1 with gain 1q21 compared to @entity1 with @entity2008 84% and NO 88%, respectively (P  <  0.008, P  =  0.600). Thus, neither HDT nor using PI or IMiDs could overcome the poor prognostic impact of gain 1q21, while these drugs and HDT seemed to improve @entity1349 in @entity1 with @entity2008 , approaching the survival in NO. Further, gain 1q21 appears to be one of the most important poor prognostic chromosomal aberrations in @entity1582 with current treatments. Trials using new drugs or allogeneic transplantation are warranted.

title: Proteasome inhibitors and IMiDs can overcome some high-risk cytogenetics in XXXX but not gain 1q21.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['multiple myeloma', 'MM']

entities_list: @entity2008 :: ('MESH:D002869', 'Disease') :: ['OA', 'other aberrations']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['TTP', 'time to progression']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['multiple myeloma']


abstract: Osteocytes are major bone cells that play a crucial role in maintaining the quality of and healing damage to bone tissue. The number of living osteocytes and canalicular networks declines in an age-dependent manner. However, the pathological effects of mitochondrial redox imbalances on osteocytes and bone metabolism have not been fully elucidated. We generated @entity19 lacking mitochondrial @entity224 dismutase 2 ( @entity183 ) in osteocytes. Like an aged bone, @entity183 depletion in the osteocytes positively enhanced the production of cellular @entity224 in vivo. A bone morphological analysis demonstrated that the @entity183 -deficient femurs showed remarkable @entity604 in an age-dependent manner. Interestingly, @entity183 loss induced markedly disorganized osteocytic canalicular networks and decreased the number of live osteocytes. Furthermore, @entity183 deficiency significantly suppressed bone formation and increased bone resorption concomitant with the upregulation of sclerostin and receptor activator of NF-kB ligand ( @entity5271 ). In vitro experiments also revealed that treatment with @entity6453 , a @entity224 inducer in mitochondria, promoted the @entity5271 expression via, in part, ERK phosphorylation. These findings demonstrate that the mitochondrial @entity224 induced in osteocytes by @entity183 ablation causes age-related @entity604 due to the @entity2331 via the deregulation of the sclerostin and @entity5271 expression.

title: Mitochondrial XXXX in osteocytes perturbs canalicular networks in the setting of age-related osteoporosis.

entities_list: @entity6453 :: ('MESH:D010269', 'Chemical') :: ['paraquat']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['impairment of canalicular networks and bone metabolism']

entities_list: @entity224 :: ('MESH:D013481', 'Chemical') :: ['superoxide']

answer: @entity224 :: (MESH:D013481,Chemical) :: ['superoxide']


abstract: OBJECTIVES: @entity1290 affect nearly one in 11 @entity1 in the United States, and among those experiencing symptoms, emergency care is common. In this population, little is known about the incidence of and factors associated with repeat @entity341 ( @entity341 ) visits. The objective was to identify associations between potentially mutable factors and the risk of an @entity341 revisit for @entity1 with @entity1290 in a large, all-payer cohort. METHODS: This was a retrospective cohort study of all @entity1 in California initially treated and released from EDs for @entity1290 between February 2008 and November 2009. A multivariable regression model was created to identify associations between @entity1 -level characteristics, area health care resources, processes of care, and the risk of repeat @entity341 visits. The primary outcome was a second @entity341 visit within 30 days of the initial discharge from emergent care. RESULTS: Among 128,564 @entity1 discharged from emergent care, 13,684 (11%) had at least one additional emergent visit for treatment of their @entity1290 . In these @entity1 , nearly one in three required hospitalization or an urgent temporizing procedure at the second visit. On multivariable analysis, the risk of an @entity341 revisit was associated with insurance status (e.g., Medicaid vs. private insurance; odds ratio [OR] = 1.52, 95% confidence interval [CI] = 1.43 to 1.61; p < 0.001). Greater access to urologic care was associated with lower odds of an @entity341 revisit (highest quartile OR = 0.88, 95% CI = 0.80 to 0.97; p < 0.01 vs. lowest quartile). In exploratory models, performance of a complete blood count was associated with a decreased odds of revisit (OR = 0.86, 95% CI = 0.75 to 0.97; p = 0.02). CONCLUSIONS: Repeat high-acuity care affects one in nine @entity1 discharged from initial emergent evaluations for @entity1290 . Access to urologic care and processes of care are associated with lower risk of repeat emergent encounters. Efforts are indicated to identify preventable causes of @entity341 revisits for @entity1290 @entity1 and design interventions to reduce the risk of high-cost, high-acuity, repeat care.

title: Emergency department revisits for @entity1 with XXXX in California.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'persons']

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['kidney stones', 'kidney stone', 'Kidney stones']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

answer: @entity1290 :: (MESH:D007669,Disease) :: ['kidney stones']


abstract: OBJECTIVES: @entity1290 affect nearly one in 11 @entity1 in the United States, and among those experiencing symptoms, emergency care is common. In this population, little is known about the incidence of and factors associated with repeat @entity341 ( @entity341 ) visits. The objective was to identify associations between potentially mutable factors and the risk of an @entity341 revisit for @entity1 with @entity1290 in a large, all-payer cohort. METHODS: This was a retrospective cohort study of all @entity1 in California initially treated and released from EDs for @entity1290 between February 2008 and November 2009. A multivariable regression model was created to identify associations between @entity1 -level characteristics, area health care resources, processes of care, and the risk of repeat @entity341 visits. The primary outcome was a second @entity341 visit within 30 days of the initial discharge from emergent care. RESULTS: Among 128,564 @entity1 discharged from emergent care, 13,684 (11%) had at least one additional emergent visit for treatment of their @entity1290 . In these @entity1 , nearly one in three required hospitalization or an urgent temporizing procedure at the second visit. On multivariable analysis, the risk of an @entity341 revisit was associated with insurance status (e.g., Medicaid vs. private insurance; odds ratio [OR] = 1.52, 95% confidence interval [CI] = 1.43 to 1.61; p < 0.001). Greater access to urologic care was associated with lower odds of an @entity341 revisit (highest quartile OR = 0.88, 95% CI = 0.80 to 0.97; p < 0.01 vs. lowest quartile). In exploratory models, performance of a complete blood count was associated with a decreased odds of revisit (OR = 0.86, 95% CI = 0.75 to 0.97; p = 0.02). CONCLUSIONS: Repeat high-acuity care affects one in nine @entity1 discharged from initial emergent evaluations for @entity1290 . Access to urologic care and processes of care are associated with lower risk of repeat emergent encounters. Efforts are indicated to identify preventable causes of @entity341 revisits for @entity1290 @entity1 and design interventions to reduce the risk of high-cost, high-acuity, repeat care.

title: Emergency department revisits for XXXX with @entity1290 in California.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Individuals post- @entity64 select slow @entity4464 ( @entity4464 ) and the major factors used to select their @entity4464 is unknown. OBJECTIVE: To determine the extent to which slow @entity4464 post- @entity64 is achieved through matching a relative force output or targeting a particular walking speed. METHODS: Ten neurologically nonimpaired individuals and fourteen chronic @entity64 survivors with @entity1158 were recruited. @entity1 were instructed to "walk at the speed that feels most comfortable" on a treadmill against 12 progressively increasing horizontal resistive force levels applied at the pelvis using a robotic system that allowed @entity1 to self-select their walking speed. We compared slope coefficients of the simple linear regressions between the observed normalized force vs. normalized speed relationship in each group to a slope of -1.0 (i.e. ideal slope for a constant relative force output) and 0.0 (i.e. ideal slope for a constant relative speed). We also compared slope coefficients between groups. RESULTS: The slope coefficients were significantly greater than -1.0 (p   <   0.001 for both) and significantly less than 0 (p   <   0.001 for both). However, compared with nonimpaired individuals, @entity1 post- @entity64 were less able to maintain their walking speed (p   =   0.003). CONCLUSIONS: The results of this study provide evidence for a complex interaction between the regulation of relative force output and intention to move at a particular speed in the selection of the @entity4464 for individuals post- @entity64 . This would suggest that therapeutic interventions should not only focus on task specific lower-limb strengthening exercises (e.g. walking against resistance), but should also focus on increasing the range of speeds at which @entity1 can safely walk.

title: Effect of progressive horizontal resistive force on the comfortable walking speed of individuals post- XXXX .

entities_list: @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia']

entities_list: @entity4464 :: ('MESH:D013009', 'Disease') :: ['comfortable walking speeds', 'CWS']

entities_list: @entity1 :: ('9606', 'Species') :: ['participant', 'Participants', 'people']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: PURPOSE: @entity784 (EATL) is a rare intestinal @entity1893 with a poor, though variable prognosis. The International Prognostic Index (IPI) and the prognostic index for @entity3191 ( @entity3191 ) have limited predictive value for outcome of EATL. The purpose of this study was to develop and validate a prognostic model for EATL, which can identify high-risk @entity1 who need more aggressive therapy. EXPERIMENTAL DESIGN: This retrospective multicenter study was based on 92 @entity1 and included 45 @entity1 diagnosed with EATL between 1999 and 2009 from the Netherlands and 47 @entity1 from England and Scotland, diagnosed with EATL between 1994 and 1998. A new @entity894 (EPI) was constructed using the RPART (recursive partitioning and regression trees) procedure. Validation was performed applying the bootstrap method. RESULTS: Three risk groups were distinguished (P < 0.0001): a high-risk group, characterized by the presence of @entity1109 [median overall survival (OS) of 2 months]; an intermediate-risk group, comprising @entity1 without @entity1109 and an IPI score >=  2 (7 months); and a low-risk group, representing @entity1 without @entity1109 and an IPI score of 0 to 1 (34 months). Internal validation showed stability of statistical significance and prognostic discrimination. In contrast with the IPI and @entity3191 , the EPI better classified @entity1 in risk groups according to their clinical outcome. CONCLUSIONS: Our new, validated, prognostic model EPI accurately predicts survival outcome in EATL and may be used for @entity1 selection for new therapeutic strategies and evaluation of clinical trials. Clin Cancer Res; 21(13); 3013-9.   2015 AACR.

title: A New and Validated Clinical Prognostic Model (EPI) for Enteropathy-Associated XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity894 :: ('MESH:C566784', 'Disease') :: ['EATL prognostic index']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['Enteropathy-associated T-cell lymphoma']

entities_list: @entity3191 :: ('MESH:D016411', 'Disease') :: ['PIT', 'peripheral T-cell lymphoma']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['non-Hodgkin lymphoma']

answer: @entity784 :: (MESH:D016399,Disease) :: ['T-cell Lymphoma']


abstract: UNASSIGNED: The mucosal immune response in the setting of intestinal @entity32 contributes to @entity14 ( @entity14 ). @entity688 signaling has central role in gut homeostasis and is @entity29 ( @entity29 ). Out of two @entity688 receptor subunits, @entity10772 and @entity15061 , the latter is shared among the @entity688 family of cytokines and activates STAT signaling. @entity4104 is oncogenic in @entity14 , however, knowledge about @entity688 signaling upstream of @entity4104 in @entity14 is lacking. Here, expression of @entity688 signaling genes was examined in matched pairs from normal and @entity5 tissue from @entity14 @entity1 showing overexpression (mRNA, protein) of @entity15061 and @entity4104 but not @entity10772 . @entity15061 over-expression was related to microsatellite- stability. Transient overexpression of @entity15061 in HT29 cells increased proliferation upon ligand activation ( @entity688 , @entity13236 ). @entity13236 and not @entity688 phosphorylated @entity4104 along with increased phosphorylation of @entity584 and ERK. A significantly higher expression of @entity13235 and @entity15061 was also confirmed in separate cohort of @entity14 samples. @entity13236 expression was elevated in gut mucosa from @entity1 with @entity29 and @entity5 which also exhibited increased expression of @entity13235 but not its co-receptor @entity15061 . Overall, these data indicate that overexpression of @entity15061 and @entity4104 contribute to @entity14 through @entity13236 / @entity4104 signaling.

title: @entity15061 overexpression promotes XXXX / @entity4104 signaling in @entity14 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'colitis-associated cancer']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['impaired in inflammatory bowel disease', 'IBD']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal carcinogenesis in microsatellite stable tumors', 'CRC', 'colorectal cancer']

answer: @entity13236 :: (50616,Gene) :: ['IL-22']


abstract: UNASSIGNED: The mucosal immune response in the setting of intestinal @entity32 contributes to @entity14 ( @entity14 ). @entity688 signaling has central role in gut homeostasis and is @entity29 ( @entity29 ). Out of two @entity688 receptor subunits, @entity10772 and @entity15061 , the latter is shared among the @entity688 family of cytokines and activates STAT signaling. @entity4104 is oncogenic in @entity14 , however, knowledge about @entity688 signaling upstream of @entity4104 in @entity14 is lacking. Here, expression of @entity688 signaling genes was examined in matched pairs from normal and @entity5 tissue from @entity14 @entity1 showing overexpression (mRNA, protein) of @entity15061 and @entity4104 but not @entity10772 . @entity15061 over-expression was related to microsatellite- stability. Transient overexpression of @entity15061 in HT29 cells increased proliferation upon ligand activation ( @entity688 , @entity13236 ). @entity13236 and not @entity688 phosphorylated @entity4104 along with increased phosphorylation of @entity584 and ERK. A significantly higher expression of @entity13235 and @entity15061 was also confirmed in separate cohort of @entity14 samples. @entity13236 expression was elevated in gut mucosa from @entity1 with @entity29 and @entity5 which also exhibited increased expression of @entity13235 but not its co-receptor @entity15061 . Overall, these data indicate that overexpression of @entity15061 and @entity4104 contribute to @entity14 through @entity13236 / @entity4104 signaling.

title: XXXX overexpression promotes @entity13236 / @entity4104 signaling in @entity14 .

answer: @entity15061 :: (3588,Gene) :: ['IL-10R2']


abstract: UNASSIGNED: The mucosal immune response in the setting of intestinal @entity32 contributes to @entity14 ( @entity14 ). @entity688 signaling has central role in gut homeostasis and is @entity29 ( @entity29 ). Out of two @entity688 receptor subunits, @entity10772 and @entity15061 , the latter is shared among the @entity688 family of cytokines and activates STAT signaling. @entity4104 is oncogenic in @entity14 , however, knowledge about @entity688 signaling upstream of @entity4104 in @entity14 is lacking. Here, expression of @entity688 signaling genes was examined in matched pairs from normal and @entity5 tissue from @entity14 @entity1 showing overexpression (mRNA, protein) of @entity15061 and @entity4104 but not @entity10772 . @entity15061 over-expression was related to microsatellite- stability. Transient overexpression of @entity15061 in HT29 cells increased proliferation upon ligand activation ( @entity688 , @entity13236 ). @entity13236 and not @entity688 phosphorylated @entity4104 along with increased phosphorylation of @entity584 and ERK. A significantly higher expression of @entity13235 and @entity15061 was also confirmed in separate cohort of @entity14 samples. @entity13236 expression was elevated in gut mucosa from @entity1 with @entity29 and @entity5 which also exhibited increased expression of @entity13235 but not its co-receptor @entity15061 . Overall, these data indicate that overexpression of @entity15061 and @entity4104 contribute to @entity14 through @entity13236 / @entity4104 signaling.

title: @entity15061 overexpression promotes @entity13236 / @entity4104 signaling in XXXX .

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal carcinogenesis']


abstract: UNASSIGNED: The mucosal immune response in the setting of intestinal @entity32 contributes to @entity14 ( @entity14 ). @entity688 signaling has central role in gut homeostasis and is @entity29 ( @entity29 ). Out of two @entity688 receptor subunits, @entity10772 and @entity15061 , the latter is shared among the @entity688 family of cytokines and activates STAT signaling. @entity4104 is oncogenic in @entity14 , however, knowledge about @entity688 signaling upstream of @entity4104 in @entity14 is lacking. Here, expression of @entity688 signaling genes was examined in matched pairs from normal and @entity5 tissue from @entity14 @entity1 showing overexpression (mRNA, protein) of @entity15061 and @entity4104 but not @entity10772 . @entity15061 over-expression was related to microsatellite- stability. Transient overexpression of @entity15061 in HT29 cells increased proliferation upon ligand activation ( @entity688 , @entity13236 ). @entity13236 and not @entity688 phosphorylated @entity4104 along with increased phosphorylation of @entity584 and ERK. A significantly higher expression of @entity13235 and @entity15061 was also confirmed in separate cohort of @entity14 samples. @entity13236 expression was elevated in gut mucosa from @entity1 with @entity29 and @entity5 which also exhibited increased expression of @entity13235 but not its co-receptor @entity15061 . Overall, these data indicate that overexpression of @entity15061 and @entity4104 contribute to @entity14 through @entity13236 / @entity4104 signaling.

title: @entity15061 overexpression promotes @entity13236 / XXXX signaling in @entity14 .

answer: @entity4104 :: (6774,Gene) :: ['STAT3']


abstract: BACKGROUND AND PURPOSE: Owing to their peculiar features and rare occurrence, @entity1756 (BBAs) of the internal carotid artery are challenging by both surgical and endovascular approaches and their proper management is uncertain. We therefore aimed to define the currently optimal treatment of ruptured BBAs in terms of mortality, outcome, rebleeding, and recurrence. METHOD: An in-depth search of electronic databases, gray literature and internet resources for ruptured BBAs was performed and complemented by data retrieval during neurosurgical congresses. Clinical and radiological characteristics, intervention details, outcomes, and the impact factor of the source journal were pooled. RESULTS: The pooled cohort comprised 311 @entity1 . Neither surgical nor endovascular methods had an impact on clinical outcome, @entity439 regrowth, remote @entity548 , or complication rate. By contrast, @entity439 clipping was a predictor of @entity954 ( @entity36815 ; 95% CI 1.2 to 34.3), and stent-assisted coiling increased the likelihood of a second treatment (OR 4.1; 95% CI 1.3 to 13.1), its conversion to another modality (OR 4.7; 95% CI 1.4 to 16.0), and incomplete @entity439 (OR 2.6; 95% CI 1.0 to 6.6). Higher impact journals were more likely to publish papers on endovascular techniques, particularly flow-diverter stents. CONCLUSIONS: None of the methods is unequivocally superior. Considering its inefficiency, stent-assisted coiling should be undertaken with caution. A time-delimited systematic review is needed to establish the most accurate treatment for ruptured BBAs.

title: Towards a new treatment paradigm for XXXX ? A rapid systematic review.

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysm obliteration', 'aneurysm']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['intraoperative bleeding']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured blood blister-like aneurysms']

answer: @entity1756 :: (MESH:D017542,Disease) :: ['ruptured blood blister-like aneurysms of the internal carotid artery']


abstract: BACKGROUND: @entity1204 is the most common gynaecologic malignancy in industrialised countries and the incidence is still rising. Primary treatment is based on preoperative risk classification and consists in most cases of hysterectomy with bilateral salpingo-oophorectomy. In @entity1 with serous and clear cell histology a complete surgical staging is mandatory. However, in routine clinical practice final histology regularly does not correspond with the preoperative histological diagnosis. This results in both over and under treatment. METHODS/DESIGN: The aim of this multicentre, prospective cohort study is to select a panel of prognostic biomarkers to improve preoperative diagnosis of @entity1204 in order to identify those @entity1 that need extended surgery and/or additional treatment. Additionally, we will determine whether incorporation of cervical cytology and comorbidity could improve this preoperative risk classification. All @entity1 treated for @entity1204 in the participating hospitals from September 2011 till December 2013 are included. @entity1 characteristics, as well as comorbidity are registered. @entity1 without preoperative histology, history of hysterectomy and/or @entity1204 or no surgical treatment including hysterectomy are excluded. The preoperative histology and final pathology will be reviewed and compared by expert pathologists. Additional immunohistochemical analysis of @entity21526 , @entity876 , ER, PR, @entity6756 , @entity983 , @entity3546 , @entity986 , Ki-67, stathmin, @entity10161 and @entity7373 will be performed. Preoperative histology will be compared with the final pathology results. Follow-up will be at least 24  months to determine risk factors for recurrence and outcome. DISCUSSION: This study is designed to improve surgical treatment of @entity1204 @entity1 . A total of 432 @entity1204 @entity1 were enrolled between 2011 and 2013. Follow-up will be completed in 2015. Preoperative histology will be evaluated systematically and background endometrium will be classified. This is the first study incorporating immunohistochemistry, cervical cytology and comorbidity to define the optimal panel of prognostic biomarkers that contribute in clinical decision making in the management of @entity1204 . TRIAL REGISTRATION: Netherlands Trial Register number NTR3503.

title: PIpelle Prospective @entity1204 (PIPENDO) study, pre-operative recognition of high risk XXXX : a multicentre prospective cohort study.

entities_list: @entity1204 :: ('MESH:D016889', 'Disease') :: ['endometrial carcinoma', 'Endometrial carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'Patient']

answer: @entity1204 :: (MESH:D016889,Disease) :: ['endometrial carcinoma']


abstract: BACKGROUND: @entity1204 is the most common gynaecologic malignancy in industrialised countries and the incidence is still rising. Primary treatment is based on preoperative risk classification and consists in most cases of hysterectomy with bilateral salpingo-oophorectomy. In @entity1 with serous and clear cell histology a complete surgical staging is mandatory. However, in routine clinical practice final histology regularly does not correspond with the preoperative histological diagnosis. This results in both over and under treatment. METHODS/DESIGN: The aim of this multicentre, prospective cohort study is to select a panel of prognostic biomarkers to improve preoperative diagnosis of @entity1204 in order to identify those @entity1 that need extended surgery and/or additional treatment. Additionally, we will determine whether incorporation of cervical cytology and comorbidity could improve this preoperative risk classification. All @entity1 treated for @entity1204 in the participating hospitals from September 2011 till December 2013 are included. @entity1 characteristics, as well as comorbidity are registered. @entity1 without preoperative histology, history of hysterectomy and/or @entity1204 or no surgical treatment including hysterectomy are excluded. The preoperative histology and final pathology will be reviewed and compared by expert pathologists. Additional immunohistochemical analysis of @entity21526 , @entity876 , ER, PR, @entity6756 , @entity983 , @entity3546 , @entity986 , Ki-67, stathmin, @entity10161 and @entity7373 will be performed. Preoperative histology will be compared with the final pathology results. Follow-up will be at least 24  months to determine risk factors for recurrence and outcome. DISCUSSION: This study is designed to improve surgical treatment of @entity1204 @entity1 . A total of 432 @entity1204 @entity1 were enrolled between 2011 and 2013. Follow-up will be completed in 2015. Preoperative histology will be evaluated systematically and background endometrium will be classified. This is the first study incorporating immunohistochemistry, cervical cytology and comorbidity to define the optimal panel of prognostic biomarkers that contribute in clinical decision making in the management of @entity1204 . TRIAL REGISTRATION: Netherlands Trial Register number NTR3503.

title: PIpelle Prospective XXXX (PIPENDO) study, pre-operative recognition of high risk @entity1204 : a multicentre prospective cohort study.

answer: @entity1204 :: (MESH:D016889,Disease) :: ['ENDOmetrial carcinoma']


abstract: CONTEXT: Although adrenal vein sampling (AVS) is the standard method for subtype diagnosis in @entity1368 (PA), protocol details including the sampling position in the adrenal vein are not standardized. OBJECTIVE: To establish the optimum sampling position in the left adrenal vein based on postoperative outcome in PA @entity1 . DESIGN AND SETTING: Retrospective study in nine referral centres. @entity1 : Of 496 consecutive PA @entity1 who underwent AVS between 2006 and 2013, 217 with successful AVS under cosyntropin stimulation, and with concomitant data from two positions: proximal (common trunk) and distal (central vein) to the junction with the inferior phrenic vein, were included. MAIN OUTCOME MEASURES: Discordant rate of subtype diagnosis between common trunk and central vein, and postoperative outcomes in @entity1 with discordant results. RESULTS: Subtype diagnosis using common trunk and central vein was discordant in 10 (4  6%) of the 217 @entity1 (k = 0  87, P < 0  05). Of these 10 @entity1 , eight with left unilateral subtype and two with bilateral subtype using common trunk data showed bilateral subtype and unilateral subtype, respectively, using central vein data. Five @entity1 with left unilateral subtype and one with bilateral subtype by common trunk data underwent unilateral adrenalectomy. All six @entity1 were cured of PA after adrenalectomy, resulting in false-negative rates of 17% (1/6) by common trunk data, and 83% (5/6) by central vein data. CONCLUSION: In view of its better potential diagnostic accuracy, technical ease, lower cost and lower risk of vein rupture, blood sampling from the common trunk of the left adrenal vein may be preferable as the standard method of AVS in @entity1 with PA, although additional studies in a larger number of cases are required.

title: Optimum position of left adrenal vein sampling for subtype diagnosis in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'patients']

entities_list: @entity1368 :: ('MESH:D006929', 'Disease') :: ['primary aldosteronism']

answer: @entity1368 :: (MESH:D006929,Disease) :: ['primary aldosteronism']


abstract: OBJECTIVES: @entity1 with @entity2012 usually harbor macroadenomas measuring between 10 and 30mm in maximal diameter. Giant ( @entity652 size >= 40mm) GH-secreting @entity977 are rarely encountered and the aim of this study is to analyze different methods for managing them. DESIGN AND METHODS: We have identified 34 @entity1 (15 @entity1 and 19 females) with @entity652 among 762 subjects (4.5%) with @entity2012 in our records, and characterized their clinical characteristics and response to treatment. RESULTS: Mean age at diagnosis was 34.9  12.5 years (range, 16-67 years). Mean @entity652 size was 49.4  9.4mm (range, 40-80mm); 30 @entity652 showed cavernous sinus invasion and 32 had suprasellar extension. Twenty-nine (85%) @entity1 had @entity227 . Mean baseline @entity442 was 3.4  1.8*ULN. All @entity1 except one underwent pituitary surgery (one to three procedures), but none achieved hormonal remission following first surgery. Among the 28 subjects with @entity227 , 14 recovered post-operatively and 13 improved. Treatment with @entity1943 analogs was given to all @entity1 after surgical failure. Six achieved remission, nine others were partially controlled ( @entity442 <1.5*ULN; 3/9 when combined with @entity9229 ), and 17 did not respond (two were lost). Nine @entity1 were treated with pegvisomant, alone (n=4) or in combination with @entity1943 analogs (n=5); five are in remission and two are partially controlled. @entity22798 -LAR achieved hormonal remission in one of the six @entity1 . Currently, after a mean follow-up period of 8.9 years, 17 @entity1 are in biochemical remission, eight are partially controlled, and seven are uncontrolled (two were lost to follow-up). CONCLUSIONS: Giant GH-secreting @entity652 are invasive, uncontrolled by surgery, and respond poorly to medical treatment. Aggressive multimodal therapy is critical for their management, enhancing control rate and biochemical remission.

title: Giant GH-secreting pituitary adenomas: management of rare and aggressive XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'men']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual disturbances', 'visual field defects']

entities_list: @entity9229 :: ('MESH:C047047', 'Chemical') :: ['cabergoline']

entities_list: @entity22798 :: ('MESH:C517782', 'Chemical') :: ['Pasireotide']

entities_list: @entity2012 :: ('MESH:D000172', 'Disease') :: ['acromegaly']

entities_list: @entity977 :: ('MESH:D010911', 'Disease') :: ['pituitary tumors']

entities_list: @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['giant adenomas', 'adenomas', 'adenoma']

answer: @entity977 :: (MESH:D010911,Disease) :: ['pituitary tumors']


abstract: BACKGROUND: -Psychological stress is a proposed risk factor for @entity65 ( @entity65 ), and @entity1005 ( @entity1005 ), the sentinel stress-related @entity146 , occurs twice as frequently in @entity1 as @entity1 . However, whether @entity1005 contributes to @entity65 risk in @entity1 is not established. METHODS AND RESULTS: -We examined @entity130 exposure and @entity1005 symptoms in relation to incident @entity65 over a 20-year period in 49,978 @entity1 in the Nurses' Health Study II. Proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for @entity65 events confirmed by additional information or medical record review [n=548, including @entity583 (n=277) and @entity64 (n=271)]. @entity130 exposure and @entity1005 symptoms were assessed using the Brief @entity130 Questionnaire and a @entity1005 screen. Compared to no @entity130 exposure, endorsing 4 or more @entity1005 symptoms was associated with increased @entity65 risk after adjusting for age, family history, and childhood factors (HR=1.60 [95% CI, 1.20-2.13]). Being @entity130 -exposed and endorsing no @entity1005 symptoms was associated with elevated @entity65 risk (HR=1.45 [95% CI, 1.15-1.83]), although being @entity130 -exposed and endorsing 1-3 @entity1005 symptoms was not. After adjusting for adult health behaviors and medical risk factors, this pattern of findings was maintained. Health behaviors and medical risk factors accounted for 14% of the @entity130 /no symptoms- @entity65 association and 47% of the @entity130 /4+ symptoms- @entity65 association. CONCLUSIONS: - @entity130 exposure and elevated @entity1005 symptoms may increase risk of @entity65 in this population of @entity1 . These findings suggest screening for @entity65 risk and reducing health risk behaviors in @entity130 -exposed @entity1 may be promising avenues for prevention and intervention.

title: XXXX Exposure and @entity1005 Symptoms Predict Onset of Cardiovascular Events in @entity1 .

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorder']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['posttraumatic stress disorder', 'PTSD']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['CVD', 'cardiovascular disease']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']

answer: @entity130 :: (MESH:D014947,Disease) :: ['Trauma']


abstract: BACKGROUND: -Psychological stress is a proposed risk factor for @entity65 ( @entity65 ), and @entity1005 ( @entity1005 ), the sentinel stress-related @entity146 , occurs twice as frequently in @entity1 as @entity1 . However, whether @entity1005 contributes to @entity65 risk in @entity1 is not established. METHODS AND RESULTS: -We examined @entity130 exposure and @entity1005 symptoms in relation to incident @entity65 over a 20-year period in 49,978 @entity1 in the Nurses' Health Study II. Proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for @entity65 events confirmed by additional information or medical record review [n=548, including @entity583 (n=277) and @entity64 (n=271)]. @entity130 exposure and @entity1005 symptoms were assessed using the Brief @entity130 Questionnaire and a @entity1005 screen. Compared to no @entity130 exposure, endorsing 4 or more @entity1005 symptoms was associated with increased @entity65 risk after adjusting for age, family history, and childhood factors (HR=1.60 [95% CI, 1.20-2.13]). Being @entity130 -exposed and endorsing no @entity1005 symptoms was associated with elevated @entity65 risk (HR=1.45 [95% CI, 1.15-1.83]), although being @entity130 -exposed and endorsing 1-3 @entity1005 symptoms was not. After adjusting for adult health behaviors and medical risk factors, this pattern of findings was maintained. Health behaviors and medical risk factors accounted for 14% of the @entity130 /no symptoms- @entity65 association and 47% of the @entity130 /4+ symptoms- @entity65 association. CONCLUSIONS: - @entity130 exposure and elevated @entity1005 symptoms may increase risk of @entity65 in this population of @entity1 . These findings suggest screening for @entity65 risk and reducing health risk behaviors in @entity130 -exposed @entity1 may be promising avenues for prevention and intervention.

title: @entity130 Exposure and XXXX Symptoms Predict Onset of Cardiovascular Events in @entity1 .

answer: @entity1005 :: (MESH:D013313,Disease) :: ['Posttraumatic Stress Disorder']


abstract: BACKGROUND: -Psychological stress is a proposed risk factor for @entity65 ( @entity65 ), and @entity1005 ( @entity1005 ), the sentinel stress-related @entity146 , occurs twice as frequently in @entity1 as @entity1 . However, whether @entity1005 contributes to @entity65 risk in @entity1 is not established. METHODS AND RESULTS: -We examined @entity130 exposure and @entity1005 symptoms in relation to incident @entity65 over a 20-year period in 49,978 @entity1 in the Nurses' Health Study II. Proportional hazards models estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for @entity65 events confirmed by additional information or medical record review [n=548, including @entity583 (n=277) and @entity64 (n=271)]. @entity130 exposure and @entity1005 symptoms were assessed using the Brief @entity130 Questionnaire and a @entity1005 screen. Compared to no @entity130 exposure, endorsing 4 or more @entity1005 symptoms was associated with increased @entity65 risk after adjusting for age, family history, and childhood factors (HR=1.60 [95% CI, 1.20-2.13]). Being @entity130 -exposed and endorsing no @entity1005 symptoms was associated with elevated @entity65 risk (HR=1.45 [95% CI, 1.15-1.83]), although being @entity130 -exposed and endorsing 1-3 @entity1005 symptoms was not. After adjusting for adult health behaviors and medical risk factors, this pattern of findings was maintained. Health behaviors and medical risk factors accounted for 14% of the @entity130 /no symptoms- @entity65 association and 47% of the @entity130 /4+ symptoms- @entity65 association. CONCLUSIONS: - @entity130 exposure and elevated @entity1005 symptoms may increase risk of @entity65 in this population of @entity1 . These findings suggest screening for @entity65 risk and reducing health risk behaviors in @entity130 -exposed @entity1 may be promising avenues for prevention and intervention.

title: @entity130 Exposure and @entity1005 Symptoms Predict Onset of Cardiovascular Events in XXXX .

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: OBJECTIVES: To describe the natural history and clinical features of sporadic @entity746 ( @entity746 ) in Chinese @entity1 , and to report data on the prognostic factors for survival. METHODS: All @entity1 referred to our @entity746 centre between 2003 and 2012 were followed up every 3   months. Survival and tracheotomy were predefined as primary outcome measures. Group differences were analysed using parametric and non-parametric tests as appropriate. Survival was analysed using the Kaplan-Meier method and Cox regression analysis. RESULTS: Of the 1624 @entity1 with @entity746 , 75.1% had limb-onset, 14.0% had bulbar-onset, 7.8% had @entity17117 ( @entity17117 ), 2.6% had progressive @entity2057 and 0.5% had primary @entity4681 . The male:female ratio was 1.7:1, and the mean age at onset was 49.8   years. The median diagnostic delay was 14   months, and the median survival time after symptom onset was 71   months. Male gender, older age at symptom onset, lower body mass index, shorter diagnostic delay, bulbar-onset @entity746 phenotype, higher Airlie House category at presentation, rural place of residence, use of traditional Chinese medicine and a history of contact with pesticides were associated with poorer survival, whereas female gender or an @entity17117 phenotype may have a better prognosis. CONCLUSIONS: The clinical characteristics and outcomes of Chinese @entity1 with @entity4572 were different compared with @entity1 from other countries. Compared with other studies, the age at onset of Chinese @entity1 was earlier, the percentage of bulbar-onset @entity746 was lower and the prognosis was better. This study substantially advances the understanding of the clinical features and epidemiology of this rare disease.

title: Natural history and clinical features of sporadic XXXX in China.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4572 :: ('MESH:C566291', 'Disease') :: ['sporadic ALS']

entities_list: @entity17117 :: ('MESH:D005409', 'Disease') :: ['FAS', 'flail-arm syndrome']

entities_list: @entity4681 :: ('MESH:D016472', 'Disease') :: ['lateral sclerosis']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis']

entities_list: @entity2057 :: ('MESH:D009133', 'Disease') :: ['muscular atrophy']

answer: @entity746 :: (MESH:D000690,Disease) :: ['amyotrophic lateral sclerosis']


abstract: OBJECTIVES: Expedited partner therapy (EPT) effectively reduces rates of reinfection with @entity1047 and increases the number of partners treated for the @entity281 . Healthcare provider (HCP) provision of EPT is low. The objective of this qualitative study was to understand HCP views and opinions regarding the use of EPT in a state where EPT is permissible but underused. METHODS: Using a purposive sampling strategy to include diverse HCPs who treat young @entity1 at risk for @entity1047 , 23 semistructured, in-depth interviews were conducted between October and December 2013. The interviews included questions about knowledge, attitudes, experiences with, and barriers and facilitators regarding the use of EPT. RESULTS: Many respondents report using EPT and believe the practice is beneficial for their @entity1 . Most providers were unaware of their colleagues' practices and had limited knowledge regarding institutional policies around EPT. HCPs noted a variety of barriers, such as fear of liability, @entity911 around the legal status of EPT and not being able to counsel @entity1 ' partners that make routine use of this practice a challenge. Facilitators of EPT include speaking on the phone with @entity1 ' partners and establishing legislation enabling EPT. CONCLUSIONS: This is the first study to qualitatively examine HCPs' perspectives on EPT in the USA. Barriers to EPT, including concerns about counselling @entity1 ' partners and the legal status of EPT, can be overcome. EPT recommendations could include the use of phone calls as part of their guidelines. Changing EPT legislation at the state level in the USA is an important factor to facilitate EPT use.

title: Healthcare providers' perspectives on expedited partner therapy for XXXX : a qualitative study.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1047 :: ('MESH:D002690', 'Disease') :: ['chlamydia']

entities_list: @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion']

answer: @entity1047 :: (MESH:D002690,Disease) :: ['chlamydia']


abstract: UNASSIGNED: MicroRNAs (miRNAs/miRs) are a class of short, single  -stranded nucleic acids, which have been investigated as potential molecular markers for various types of @entity5 . The gold  -standard and most sensitive method for comparing miRNA levels in @entity5 tissues is reverse transcription  -quantitative polymerase chain reaction (RT  -qPCR). This technique uses stably expressed genes for normalisation. The aim of the present study was to improve this model of analysis in the context of RT  -qPCR results. A total of six known miRNAs (let  -7a, @entity12425 , @entity13825 , @entity6557 , miR  -125b and @entity21275 ), @entity60709 RNA and five mRNAs [erb  -b2 receptor @entity4149 kinase  2 ( @entity1722 ), @entity56256 synthase and polymerase (RNA)  II (DNA directed) polypeptide A] were analysed pair  -wise, in order to determine which biomarker pairs best correlated with the histological groups of 27  @entity0 samples. The lowest P  -values and the highest area under the curve values in the receiver operating characteristic analysis were used to select the optimum ratios for discrimination among groups. Among the 21 pairs, @entity12425 / @entity13825 and @entity6557 / @entity60709 best discriminated three groups of samples with different @entity5 grades (G  classification). miR  -125b/ @entity21275 best discriminated two groups of samples with different @entity5 sizes (pT), let  -7a/ @entity60709 best discriminated two groups of samples with different lymph node status (pN), and let  -7a/miR  -125b best discriminated groups of samples with negative and positive @entity2931 and @entity1420 receptor status. No pair of miRNAs was found to discriminate well between groups with either a negative or positive @entity1 @entity1722 ( @entity1722 ) status. However, one miRNA/mRNA pair, @entity6557 / @entity1722 , discriminated @entity1722  -negative from @entity1722  -positive groups. The @entity0 samples investigated in the present study were grouped by immunohistological methods into three molecular classes: Luminal, @entity1722 positive and basal (L, H and B, respectively). In order to discern L from H and L from B, two miRNA pairs were selected: @entity6557 /miR  -125b and @entity6557 / @entity21275 . In conclusion, the pair  -wise method of RT  -qPCR data analysis may be a reasonable alternative to the standard method of using stably expressed reference genes, such as @entity60709 RNA, for normalisation. This method may increase the classification power of miRNA biomarkers in @entity0 diagnostics.

title: Relative levels of let  -7a, XXXX , @entity13825 , @entity6557 , miR  -125b and @entity21275 as potential molecular markers to evaluate grade, receptor status and molecular type in @entity0 .

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumour']

entities_list: @entity2931 :: ('CHEBI:50114', 'Chemical') :: ['oestrogen']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity56256 :: ('MESH:C024393', 'Chemical') :: ['hydroxymethylbilane']

entities_list: @entity1722 :: ('2064', 'Gene') :: ['ERBB2', 'epidermal growth factor receptor  2', 'HER2']

answer: @entity12425 :: (406952,Gene) :: ['miR  -17']


abstract: UNASSIGNED: MicroRNAs (miRNAs/miRs) are a class of short, single  -stranded nucleic acids, which have been investigated as potential molecular markers for various types of @entity5 . The gold  -standard and most sensitive method for comparing miRNA levels in @entity5 tissues is reverse transcription  -quantitative polymerase chain reaction (RT  -qPCR). This technique uses stably expressed genes for normalisation. The aim of the present study was to improve this model of analysis in the context of RT  -qPCR results. A total of six known miRNAs (let  -7a, @entity12425 , @entity13825 , @entity6557 , miR  -125b and @entity21275 ), @entity60709 RNA and five mRNAs [erb  -b2 receptor @entity4149 kinase  2 ( @entity1722 ), @entity56256 synthase and polymerase (RNA)  II (DNA directed) polypeptide A] were analysed pair  -wise, in order to determine which biomarker pairs best correlated with the histological groups of 27  @entity0 samples. The lowest P  -values and the highest area under the curve values in the receiver operating characteristic analysis were used to select the optimum ratios for discrimination among groups. Among the 21 pairs, @entity12425 / @entity13825 and @entity6557 / @entity60709 best discriminated three groups of samples with different @entity5 grades (G  classification). miR  -125b/ @entity21275 best discriminated two groups of samples with different @entity5 sizes (pT), let  -7a/ @entity60709 best discriminated two groups of samples with different lymph node status (pN), and let  -7a/miR  -125b best discriminated groups of samples with negative and positive @entity2931 and @entity1420 receptor status. No pair of miRNAs was found to discriminate well between groups with either a negative or positive @entity1 @entity1722 ( @entity1722 ) status. However, one miRNA/mRNA pair, @entity6557 / @entity1722 , discriminated @entity1722  -negative from @entity1722  -positive groups. The @entity0 samples investigated in the present study were grouped by immunohistological methods into three molecular classes: Luminal, @entity1722 positive and basal (L, H and B, respectively). In order to discern L from H and L from B, two miRNA pairs were selected: @entity6557 /miR  -125b and @entity6557 / @entity21275 . In conclusion, the pair  -wise method of RT  -qPCR data analysis may be a reasonable alternative to the standard method of using stably expressed reference genes, such as @entity60709 RNA, for normalisation. This method may increase the classification power of miRNA biomarkers in @entity0 diagnostics.

title: Relative levels of let  -7a, @entity12425 , @entity13825 , @entity6557 , miR  -125b and XXXX as potential molecular markers to evaluate grade, receptor status and molecular type in @entity0 .

answer: @entity21275 :: (406989,Gene) :: ['miR  -206']


abstract: UNASSIGNED: MicroRNAs (miRNAs/miRs) are a class of short, single  -stranded nucleic acids, which have been investigated as potential molecular markers for various types of @entity5 . The gold  -standard and most sensitive method for comparing miRNA levels in @entity5 tissues is reverse transcription  -quantitative polymerase chain reaction (RT  -qPCR). This technique uses stably expressed genes for normalisation. The aim of the present study was to improve this model of analysis in the context of RT  -qPCR results. A total of six known miRNAs (let  -7a, @entity12425 , @entity13825 , @entity6557 , miR  -125b and @entity21275 ), @entity60709 RNA and five mRNAs [erb  -b2 receptor @entity4149 kinase  2 ( @entity1722 ), @entity56256 synthase and polymerase (RNA)  II (DNA directed) polypeptide A] were analysed pair  -wise, in order to determine which biomarker pairs best correlated with the histological groups of 27  @entity0 samples. The lowest P  -values and the highest area under the curve values in the receiver operating characteristic analysis were used to select the optimum ratios for discrimination among groups. Among the 21 pairs, @entity12425 / @entity13825 and @entity6557 / @entity60709 best discriminated three groups of samples with different @entity5 grades (G  classification). miR  -125b/ @entity21275 best discriminated two groups of samples with different @entity5 sizes (pT), let  -7a/ @entity60709 best discriminated two groups of samples with different lymph node status (pN), and let  -7a/miR  -125b best discriminated groups of samples with negative and positive @entity2931 and @entity1420 receptor status. No pair of miRNAs was found to discriminate well between groups with either a negative or positive @entity1 @entity1722 ( @entity1722 ) status. However, one miRNA/mRNA pair, @entity6557 / @entity1722 , discriminated @entity1722  -negative from @entity1722  -positive groups. The @entity0 samples investigated in the present study were grouped by immunohistological methods into three molecular classes: Luminal, @entity1722 positive and basal (L, H and B, respectively). In order to discern L from H and L from B, two miRNA pairs were selected: @entity6557 /miR  -125b and @entity6557 / @entity21275 . In conclusion, the pair  -wise method of RT  -qPCR data analysis may be a reasonable alternative to the standard method of using stably expressed reference genes, such as @entity60709 RNA, for normalisation. This method may increase the classification power of miRNA biomarkers in @entity0 diagnostics.

title: Relative levels of let  -7a, @entity12425 , XXXX , @entity6557 , miR  -125b and @entity21275 as potential molecular markers to evaluate grade, receptor status and molecular type in @entity0 .

answer: @entity13825 :: (407019,Gene) :: ['miR  -27b']