abstract: BACKGROUND: Insulin-resistant states, such as @entity209 and @entity6 ( @entity6 ), have been associated with chronic low-grade systemic @entity32 . Elevated levels of @entity650 ( @entity650 ), monocyte chemoattractant protein ( @entity2842 ) and @entity1851 (hs-CRP), are found in @entity1 with @entity2412 . @entity2178 ( @entity2178 ), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of @entity1564 , an angiotensin receptror blocker, in the chronic low-grade @entity32 observed in @entity3918 2. MATERIALS AND METHODS: Seventeen @entity1 with @entity6 of <5years duration were recruited for the study. @entity1 received 4mg of @entity1564 , an angiotensin receptor blocker, for 6months. Blood levels of @entity650 , @entity2842 , hs-CRP and other inflammatory indices were measured before and at the end of @entity1564 administration. RESULTS: At the end of treatment with @entity1564 , @entity650 levels decreased significantly (P<0  05). Serum levels of @entity2842 and hs-CRP showed a trend for significant decrease with treatment (P<0  08 and P<0  09, respectively). Statistically significant correlations were found between hs-CRP and @entity2842 (r=0  623, P<   0  05), @entity650 and @entity2842 (r=0  703, P<0  05) and TRT and @entity2842 (r=0  752, P<0  05), before but not at the end of @entity1564 administration. CONCLUSIONS: @entity1564 could decrease the low-grade @entity32 of type 2 @entity3918 as shown by the decrease of inflammatory mediators. Thus, angiotensin receptor blockers could be useful for treating @entity1 with @entity6 not only for their antihypertensive capacity but also for their anti-inflammatory actions.

title: Angiotensin blockade in XXXX @entity1 decreases insulin resistance-associated low-grade @entity32 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus type 2', 'DM2']

entities_list: @entity2178 :: ('183', 'Gene') :: ['Angiotensin II', 'Ang II']

entities_list: @entity1564 :: ('MESH:C081643', 'Chemical') :: ['Candesartan', 'candesartan']

entities_list: @entity2412 :: ('MESH:D048909', 'Disease') :: ['type 2 diabetes with and without complications']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic']


abstract: BACKGROUND: Insulin-resistant states, such as @entity209 and @entity6 ( @entity6 ), have been associated with chronic low-grade systemic @entity32 . Elevated levels of @entity650 ( @entity650 ), monocyte chemoattractant protein ( @entity2842 ) and @entity1851 (hs-CRP), are found in @entity1 with @entity2412 . @entity2178 ( @entity2178 ), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of @entity1564 , an angiotensin receptror blocker, in the chronic low-grade @entity32 observed in @entity3918 2. MATERIALS AND METHODS: Seventeen @entity1 with @entity6 of <5years duration were recruited for the study. @entity1 received 4mg of @entity1564 , an angiotensin receptor blocker, for 6months. Blood levels of @entity650 , @entity2842 , hs-CRP and other inflammatory indices were measured before and at the end of @entity1564 administration. RESULTS: At the end of treatment with @entity1564 , @entity650 levels decreased significantly (P<0  05). Serum levels of @entity2842 and hs-CRP showed a trend for significant decrease with treatment (P<0  08 and P<0  09, respectively). Statistically significant correlations were found between hs-CRP and @entity2842 (r=0  623, P<   0  05), @entity650 and @entity2842 (r=0  703, P<0  05) and TRT and @entity2842 (r=0  752, P<0  05), before but not at the end of @entity1564 administration. CONCLUSIONS: @entity1564 could decrease the low-grade @entity32 of type 2 @entity3918 as shown by the decrease of inflammatory mediators. Thus, angiotensin receptor blockers could be useful for treating @entity1 with @entity6 not only for their antihypertensive capacity but also for their anti-inflammatory actions.

title: Angiotensin blockade in @entity6 @entity1 decreases insulin resistance-associated low-grade XXXX .

answer: @entity32 :: (MESH:D007249,Disease) :: ['inflammation']


abstract: BACKGROUND: Insulin-resistant states, such as @entity209 and @entity6 ( @entity6 ), have been associated with chronic low-grade systemic @entity32 . Elevated levels of @entity650 ( @entity650 ), monocyte chemoattractant protein ( @entity2842 ) and @entity1851 (hs-CRP), are found in @entity1 with @entity2412 . @entity2178 ( @entity2178 ), a potent vasopressor, seems to regulate also the expression of the above inflammatory mediators acting as proinflammatory cytokine. In this study, we examined the effects of @entity1564 , an angiotensin receptror blocker, in the chronic low-grade @entity32 observed in @entity3918 2. MATERIALS AND METHODS: Seventeen @entity1 with @entity6 of <5years duration were recruited for the study. @entity1 received 4mg of @entity1564 , an angiotensin receptor blocker, for 6months. Blood levels of @entity650 , @entity2842 , hs-CRP and other inflammatory indices were measured before and at the end of @entity1564 administration. RESULTS: At the end of treatment with @entity1564 , @entity650 levels decreased significantly (P<0  05). Serum levels of @entity2842 and hs-CRP showed a trend for significant decrease with treatment (P<0  08 and P<0  09, respectively). Statistically significant correlations were found between hs-CRP and @entity2842 (r=0  623, P<   0  05), @entity650 and @entity2842 (r=0  703, P<0  05) and TRT and @entity2842 (r=0  752, P<0  05), before but not at the end of @entity1564 administration. CONCLUSIONS: @entity1564 could decrease the low-grade @entity32 of type 2 @entity3918 as shown by the decrease of inflammatory mediators. Thus, angiotensin receptor blockers could be useful for treating @entity1 with @entity6 not only for their antihypertensive capacity but also for their anti-inflammatory actions.

title: Angiotensin blockade in @entity6 XXXX decreases insulin resistance-associated low-grade @entity32 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVES: To retrospectively assess the long-term outcome for @entity235 that were presented with collapse, @entity1163 or exercise intolerance for which an underlying cause is not identified. METHODS: The clinical records of animals presenting to two practices were assessed. @entity235 which presented for collapse, @entity1163 or exercise intolerance at least 6 months previously and did not receive a definitive diagnosis despite investigation were included. Follow-up of these cases was carried out by conducting telephone interviews with the owners. RESULTS: One hundred and fifty-three cases were successfully followed up. Clinical signs had resolved in 64 cases (42%), 35 @entity235 (23%) were continuing to exhibit clinical signs, although 22 of these had improved without medical intervention. In 17 cases (11%), a diagnosis had subsequently been made or treatment was being administered and 37 @entity235 (24%) had died. Of the deaths, 18 (12%) were considered to be related to the original presentation. The overall prevalence of @entity204 and deterioration related to the problems investigated was 16  2% of cases. Death in boxers was significantly more common than in other breeds (36%). CLINICAL SIGNIFICANCE: Death and deterioration are uncommon outcomes for @entity235 other than boxers presenting with collapse, @entity1163 and exercise intolerance for which a definitive diagnosis cannot be made.

title: A retrospective study of 153 cases of undiagnosed collapse, XXXX or exercise intolerance: the outcomes.

answer: @entity1163 :: (MESH:D013575,Disease) :: ['syncope']


abstract: An 18-year-old @entity1 was evaluated for a chronic productive cough and @entity1353 . She was subsequently diagnosed with mediastinal @entity1893 ( @entity1893 ). A covered @entity1702 ( @entity1702 ) was implanted to relieve narrowing in for both main bronchi. The @entity1893 went into complete remission after six chemotherapy cycles, but atelectasis developed in the left lower lobe 18 months after @entity1702 insertion. The left main bronchus was completely occluded by granulation tissue. However, the right main bronchus and intermedius bronchus were patent. Granulation tissue was observed adjacent to the @entity1702 . The granulation tissue and the @entity1702 were excised, and a @entity1346 stent was successfully implanted using a rigid bronchoscope. @entity1702 is advantageous owing to its easy implantation, but there are considerable potential complications such as severe reactive granulation, stent @entity397 , and ventilation failure in serious cases. Therefore, @entity1702 should be avoided whenever possible in @entity1 with benign airway disease. This case highlights that @entity1702 implantation should be avoided even in malignant @entity1224 cases if the underlying malignancy is curable.

title: Serious Complications after Self-expandable Metallic Stent Insertion in a XXXX with Malignant Lymphoma.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity1702 :: ('MESH:D013651', 'Disease') :: ['self-expandable metallic stent', 'SEMS']

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ['NHL', 'non-Hodgkin lymphoma']

entities_list: @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway obstruction']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: The effect of inclusion of garlic essential oil (EO) at 33, 66 and 100   g mL(-1), raw garlic (GAR) at 5, 10 and 15 mg mL(-1) and monensin (MON) at 7.5   g mL(-1) of incubation medium on @entity62 ( @entity62 ) was studied with in vitro gas production, ANKOM daisy(II) and conventional in vitro (IVOMD) methods. The material was incubated with @entity742 ruminal fluid and the experimental design was a completely randomized design. Cumulative gas production was recorded at 0, 2, 4, 6, 8, 12, 16, 24, 36, 48, 72 and 96 hours of incubation. Conventional in vitro @entity62 was determined after 48 hours incubation in acid and pepsin solutions. Samples for Daisy(II) @entity62 prepared according to the operating instructions supplied by ANKOM(  ) Tech. Co., Fairport, USA. Compared to @entity62 ( @entity62 ), Daisy(II) and gas production techniques overestimated (P < 0.05) @entity62 . The addition of EO and MON reduced (P < 0.05) the organic matter (OM), neutral detergent fiber (NDF), acid-detergent fiber (ADF) digestion, and gas production volume. The potential of gas production and rate of gas production for EO and MON were the lowest; however, these variables were higher for GAR supplemented groups. It was concluded that raw garlic could be of great interest for its usage as a modulator of ruminal fermentation.

title: In vitro assessment of the digestibility of forage based XXXX diet, supplemented with raw garlic, garlic oil and monensin.

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['IVDMD', 'organic matter digestibility', 'OMD', 'in vitro dry matter digestibility']

answer: @entity742 :: (9940,Species) :: ['sheep']


abstract: This study is an investigation of the relationship between morphological, neuropsychological, and clinical measurements, all presumably contributing to an expert's diagnosis of @entity195 . Morphological assessment was carried out by linear measurements taken from the photographs of the CT scanners display. The battery of tests comprised instruments able to evaluate performance (WAIS, Benton test, d2 test, Trail Making test) as well as personality (FPI) from a quantitative point of view. For clinical assessment the Assessment Scale for Gerontopsychiatry (AGP) was used. A group of 39 @entity1 suffering from mild to severe @entity303 was studied. The results show strong correlations between some sub-tests of the WAIS and certain CT measurements but fail to show comparable features in using the full scale IQ. The other cognitive tests did not work as well in detecting @entity1010 . Surprisingly, the personality inventory (FPI) showed some correlations with @entity1010 . A number of correlations between morphological and clinical variables were found as well, consistent with well-known clinical experience. Topographical features will be discussed supporting the view that @entity75 in the progress of @entity195 take the form of distinct patterns.

title: Correlations between psychopathology, psychological test results and computerized tomography changes in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['cerebral lesions']

entities_list: @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['senile dementia']

answer: @entity195 :: (MESH:D000544,Disease) :: ['senile dementia']


abstract: Introduction : A prospective study was carried out in Department of Obstretics and Gynaecology in KIMS Hospital Bangalore, India, for a period of 18 mnth from 2005-2008. Sixty cases were selected for this study from @entity1 who were above the age of 40 y and who were presented with a history of abnormal uterine @entity548 (after excluding pregnancy and its complications, @entity1 with local causes of @entity548 , @entity1 with @entity189 cervix and @entity5851 ). All @entity1 underwent transvaginal sonography and hysteroscopy. Dilatation and curettage was done in cases with abnormal endometrial findings and sample sent for histopathology examination. Performance of TVS pick up rate in relation to hysteroscopy were analysed by various statistical methods. RESULTS: In the present study, transvaginal ultrasound showed an accuracy of 83.3% in detecting the proliferative phase and 66.67% in detecting the secretory phase. TVS has a sensitivity of 0% for a local lesion (intra-cavitary) of endometrial cavity. TVS was also preferable in case of post-menopausal @entity1 with endometrial thickness less than 4mm. CONCLUSION: Both TVS and hysteroscopy can detect endometrial intracavitary abnormalities with varying accuracies. These can supplement and enhance the accuracy of tissue diagnosis. Thus, the first procedure to which @entity1 with AUB are to be subjected should be TVS followed by hysteroscopy and hysteroscopically directed biopsy, wherever required.

title: Role of transvaginal sonography and diagnostic hysteroscopy in abnormal uterine XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity548 :: (MESH:D006470,Disease) :: ['bleeding']


abstract: @entity1697 ( @entity1697 ) has been considered as a strict contraindication to transurethral resection of the prostate (TURP). In recent years, some studies have shown that holmium laser enucleation of the prostate (HoLEP) has less @entity190 compared to TURP. Thus we have performed HoLEP in @entity1 with @entity1067 ( @entity1067 ) under continuous @entity1697 from September 2009, and herein we report our first nine cases. @entity1 received HoLEP by a single surgeon at our institution. HoLEP was performed successfully in all @entity1 . The mean times to complete enucleation and morcellation were 48.2 and 5.1 minutes, respectively. The mean tissue weight of enucleation was 37 grams. The mean hemoglobin and @entity1372 loss after HoLEP were 1.7 g/dl and 1.3 mEq/L, respectively, and the catheterization time was 1.6 days. Blood transfusion, clot retention or transurethral resection syndrome were not observed in any cases. HoLEP has excellent hemostatic properties, and is a safe and effective procedure for @entity1 with symptomatic @entity1067 under the condition of continuous @entity1697 .

title: [Holmium laser enucleation of the prostate (HoLEP) in XXXX with continuous oral anticoagulation: first reported cases in Japan].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1697 :: ('MESH:D009062', 'Disease') :: ['Oral anticoagulation', 'OA']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity1067 :: ('MESH:D011470', 'Disease') :: ['benign prostatic hyperplasia', 'BPH']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: The postcranial evidence for the Australopithecus genus indicates that australopiths were able bipeds; however, the morphology of the forelimbs and particularly that of the shoulder girdle suggests that they were partially adapted to an arboreal lifestyle. The nature of such arboreal adaptations is still unclear, as are the kind of @entity146 in which australopiths might have engaged. In this study we analyzed the shape of the shoulder joint (proximal humerus and glenoid cavity of the scapula) of three australopith specimens: A.L. 288-1 (A. afarensis), @entity2031 7 (A. africanus) and Omo 119-73-2718 (Australopithecus sp.) with three-dimensional geometric morphometrics. The morphology of the specimens was compared with that of a wide array of living anthropoid taxa and some additional fossil hominins (the Homo erectus specimen KNM-WT 15000 and the @entity4840 specimen Tabun 1). Our results indicate that A.L. 288-1 shows mosaic traits resembling @entity1 and Pongo, whereas the @entity2031 7 shoulder is most similar to the arboreal apes and does not present affinities with @entity1 . Omo 119-73-2718 exhibits morphological affinities with the more arboreal and partially suspensory New World monkey Lagothrix. The shoulder of the australopith specimens thus shows a combination of primitive and derived traits (humeral globularity, enhancement of internal and external rotation of the joint), related to use of the arm in overhead positions. The genus Homo specimens show overall affinities with @entity1 at the shoulder, indicating full correspondence of these hominin shoulders with the modern @entity1 morphotype.

title: Like Father, Like Son: Assessment of the Morphological Affinities of A.L. 288-1 (A. afarensis), XXXX 7 (A. africanus) and Omo 119-73-2718 (Australopithecus sp.) through a Three-Dimensional Shape Analysis of the Shoulder Joint.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'H. sapiens']

entities_list: @entity4840 :: ('63221', 'Species') :: ['H. neanderthalensis']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['arboreal behaviors']

answer: @entity2031 :: (412,Gene) :: ['Sts']


abstract: In addition to classical spinocerebellar pathways, the cerebellum receives information from the spinal cord indirectly via spino-bulbar-cerebellar systems. One of the structures in this pathway is the lateral reticular nucleus (LRt). We performed series of experiments to investigate the organization and neurotransmitter content of spinoreticular tract (SRT) neurons in the lumbar spinal cord that project to the LRt. Three @entity35 received injections of the b subunit of Cholera toxin ( @entity34981 ) or Fluorogold (FG) within the left and right LRt. The majority of SRT cells (56-61%) were found within the contralateral medial intermediate gray matter where small numbers (7-10%) of double-labeled cells were also present on both sides of the cord. Six @entity35 received unilateral spinal injections of @entity34981 to label spinal projections to the LRt. Injections of FG were made also into the anterior lobe of the cerebellum to label LRt pre-cerebellar neurons. Terminals were found mainly ipsilateral to spinal injection sites within the central and ventrolateral regions of the LRt. Immunocytochemical analysis of SRT terminals revealed that the majority (75%) were contained vesicular @entity2227 transporter 2 but a minority (20%) contained the vesicular @entity1246 transporter. The inhibitory subpopulation was found to be GABAergic, glycinergic, or contained both transmitters. Inhibitory and excitatory terminals were present within overlapping regions of the nucleus. Most @entity34981 terminals contacting LRt pre-cerebellar neurons were excitatory (80%) whereas a minority were inhibitory and most cells (88%) received contacts from both inhibitory and excitatory terminals. This study shows that SRT axons in the LRt have the capacity to exert direct excitatory and inhibitory actions on LRt pre-cerebellar neurons. Thus spinal cord input has the capacity to facilitate or depress the activity of individual LRt cells which in turn adjust activity in the cerebellum to produce coordinated motor behaviors.

title: The spino-bulbar-cerebellar pathway: organization and neurochemical properties of spinal cells that project to the lateral reticular nucleus in the XXXX .

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Schema Therapy has shown promising results for @entity1314 but there is a limited evidence base for group schema therapy ( @entity17649 ) with @entity1314 . The aim of this study was to explore the feasibility, acceptability, and preliminary effectiveness of @entity17649 in a sample of eight @entity1 with @entity1314 (with a predominant diagnosis of @entity1314 ) and high levels of comorbidity. Treatment was comprised of 20 sessions which included cognitive, behavioral, and experiential techniques. Specific schema-based strategies were chosen for a diagnostically mixed group of @entity1314 clients. Six @entity1 attended until end of treatment and two dropped-out before mid-treatment. All outcome measures showed changes with large effect sizes in @entity1314 symptom severity, @entity308 and @entity148 levels between pre-therapy and follow-up. Four @entity1 achieved a loss of @entity1314 diagnosis at the end of therapy. By follow-up, five @entity1 had achieved a loss of diagnosis, suggesting that @entity1 derived ongoing benefits from the group even after treatment ended. Six @entity1 no longer met criteria for @entity308 at the end of treatment and this was maintained for all @entity1 at 6-month follow-up. At follow-up, the majority of @entity1 showed clinically significant change on the Global Symptom Index (GSI). For the Schema Mode Inventory (SMI) maladaptive modes, the majority of @entity1 showed improvement at follow-up. At follow-up, 40% of @entity1 showed clinically significant change on the SMI adaptive modes. Qualitative feedback indicates that the group helps to normalize @entity1 ' psychological experiences and difficulties and promotes self-expression and self-disclosure, while reducing inhibition. Preliminary results suggest that short-term @entity17649 may benefit those with @entity1314 , but generalizability is limited by the small sample size and lack of control group.

title: Short-term group schema therapy for XXXX : a pilot study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['mixed personality disorders', 'personality disorder', 'avoidant personality disorder', 'personality disorders']

answer: @entity1314 :: (MESH:D010554,Disease) :: ['mixed personality disorders']


abstract: A predictive technique in the management of @entity1 with @entity5 could improve the therapeutic index by allowing better individualization of treatment. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a noninvasive technique that can provide anatomical and physiological information on the @entity5 and its microenvironment. We studied the effect of chemotherapy ( @entity136 ), anti-angiogenesis therapy ( @entity2240 ) and radiotherapy on the kinetics of DCE-MRI parameters in a preclinical model of @entity788 using P846, a new low-diffusible contrast agent. @entity19 underwent DCE-MRI before treatment ( @entity71905 ), after 1 week of treatment (MRI2), and after 1 additional week (MRI3). Combined treatment with radiotherapy and @entity2240 had a synergistic effect on @entity5 growth. In radiotherapy/ @entity2240 -treated @entity19 , a decrease in K(trans) at MRI2 predicted its superior antivascular and antitumor effect at an early time. An increased K(trans) at MRI2, as seen in @entity136 - and @entity136 / @entity2240 -treated @entity19 , reflects increased permeability for P846 and might predict a smaller therapeutic effect at this early time. This study shows that the kinetics of DCE-MRI parameters depends on the contrast agent used. P846 appears to be a promising low-diffusible agent to monitor therapeutic effects in this preclinical @entity5 model, but further studies are needed to compare its behavior with @entity7241 and macromolecular-weight contrast agents. @entity2240 as a radiosensitizer is promising for future clinical trials in @entity1 @entity788 .

title: Noninvasive monitoring of therapy-induced microvascular changes in a XXXX model using dynamic contrast-enhanced magnetic resonance imaging with P846, a new low-diffusible gadolinium-based contrast agent.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer']

entities_list: @entity2240 :: ('MESH:C473478', 'Chemical') :: ['Sunitinib', 'sunitinib']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic cancer']


abstract: BACKGROUND: Blunt @entity3511 is a leading cause of @entity204 in @entity130 @entity1 . A reliable test predicting @entity548 would be a novel method. The study objective was to assess the diagnostic accuracy of plasma @entity3265 in detection of @entity548 in @entity1 with blunt @entity1661 (BAT). MATERIALS AND METHODS: In this observational study, all @entity1 suffering from BAT, referred to our university teaching hospital included. The levels of @entity3265 were measured at the time of emergency department admission and 1 h after initial treatment. Demographic data, vital signs, and venous blood gas reports were recorded. Findings of contrast-enhanced abdominopelvic computed tomography scan and laparotomy were assumed as a gold standard for @entity3511 . RESULTS: A total of 104 @entity1 was enrolled in the study. 15 @entity1 (14.4%) had @entity548 and the mean plasma @entity3265 level in this group was significantly higher than the other @entity1 on admission time (101.73    5.41  g/dL vs. 47.36    26.31  g/dL, P < 0.001). On receiver-operator characteristic curve analysis, in cutoff point of 89  g/dL, the sensitivity, specificity, positive and negative likelihood ratios were 100% (95% confidence interval [CI], 79.6-100), 93.26% (95% CI, 86-96.8), 14.83 (95% CI, 6.84-32.12), and 0, respectively. CONCLUSION: The study findings suggest the measurement of @entity3265 level at the time of admission in the @entity1 with BAT would be a useful test predicting @entity548 . Furthermore, decrease in the @entity3265 level could be a useful marker for monitoring response to treatment in these @entity1 .

title: Role of plasma @entity3265 level in detecting @entity548 following blunt XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intra-abdominal hemorrhage', 'intra-abdominal bleeding']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal trauma']

entities_list: @entity3511 :: ('MESH:D000007', 'Disease') :: ['abdominal injury', 'abdominal injuries']

answer: @entity1661 :: (MESH:D000008,Disease) :: ['abdominal trauma']


abstract: BACKGROUND: Blunt @entity3511 is a leading cause of @entity204 in @entity130 @entity1 . A reliable test predicting @entity548 would be a novel method. The study objective was to assess the diagnostic accuracy of plasma @entity3265 in detection of @entity548 in @entity1 with blunt @entity1661 (BAT). MATERIALS AND METHODS: In this observational study, all @entity1 suffering from BAT, referred to our university teaching hospital included. The levels of @entity3265 were measured at the time of emergency department admission and 1 h after initial treatment. Demographic data, vital signs, and venous blood gas reports were recorded. Findings of contrast-enhanced abdominopelvic computed tomography scan and laparotomy were assumed as a gold standard for @entity3511 . RESULTS: A total of 104 @entity1 was enrolled in the study. 15 @entity1 (14.4%) had @entity548 and the mean plasma @entity3265 level in this group was significantly higher than the other @entity1 on admission time (101.73    5.41  g/dL vs. 47.36    26.31  g/dL, P < 0.001). On receiver-operator characteristic curve analysis, in cutoff point of 89  g/dL, the sensitivity, specificity, positive and negative likelihood ratios were 100% (95% confidence interval [CI], 79.6-100), 93.26% (95% CI, 86-96.8), 14.83 (95% CI, 6.84-32.12), and 0, respectively. CONCLUSION: The study findings suggest the measurement of @entity3265 level at the time of admission in the @entity1 with BAT would be a useful test predicting @entity548 . Furthermore, decrease in the @entity3265 level could be a useful marker for monitoring response to treatment in these @entity1 .

title: Role of plasma @entity3265 level in detecting XXXX following blunt @entity1661 .

answer: @entity548 :: (MESH:D006470,Disease) :: ['intra-abdominal hemorrhage']


abstract: BACKGROUND: Blunt @entity3511 is a leading cause of @entity204 in @entity130 @entity1 . A reliable test predicting @entity548 would be a novel method. The study objective was to assess the diagnostic accuracy of plasma @entity3265 in detection of @entity548 in @entity1 with blunt @entity1661 (BAT). MATERIALS AND METHODS: In this observational study, all @entity1 suffering from BAT, referred to our university teaching hospital included. The levels of @entity3265 were measured at the time of emergency department admission and 1 h after initial treatment. Demographic data, vital signs, and venous blood gas reports were recorded. Findings of contrast-enhanced abdominopelvic computed tomography scan and laparotomy were assumed as a gold standard for @entity3511 . RESULTS: A total of 104 @entity1 was enrolled in the study. 15 @entity1 (14.4%) had @entity548 and the mean plasma @entity3265 level in this group was significantly higher than the other @entity1 on admission time (101.73    5.41  g/dL vs. 47.36    26.31  g/dL, P < 0.001). On receiver-operator characteristic curve analysis, in cutoff point of 89  g/dL, the sensitivity, specificity, positive and negative likelihood ratios were 100% (95% confidence interval [CI], 79.6-100), 93.26% (95% CI, 86-96.8), 14.83 (95% CI, 6.84-32.12), and 0, respectively. CONCLUSION: The study findings suggest the measurement of @entity3265 level at the time of admission in the @entity1 with BAT would be a useful test predicting @entity548 . Furthermore, decrease in the @entity3265 level could be a useful marker for monitoring response to treatment in these @entity1 .

title: Role of plasma XXXX level in detecting @entity548 following blunt @entity1661 .

answer: @entity3265 :: (MESH:D000641,Chemical) :: ['ammonia']


abstract: BACKGROUND: @entity12042 is one of the main differential diagnoses in the investigation of nephrotic @entity644 in adults, especially elderly @entity1 . OBJECTIVES: The aim of this article is to contribute to international research with epidemiologic data of @entity12042 , given the lack of uniformity described in the literature. @entity1 AND METHODS: A retrospective study of 37 cases of @entity12042 diagnosed by kidney biopsy, between 2000 and 2011, considering epidemiological, clinical and laboratory data. RESULTS: Subjects aged between 32 and 80 years. Of the 37 cases, 21 (56.8%) were diagnosed as non-light chain (non- @entity2783 ) @entity12042 and 16 (43.2%) as light chain @entity2783 ( @entity2783 ). There was seen an increase in number of both @entity2783 and non- @entity2783 cases, with a slight predominance in non- @entity2783 . The mean 24-hour @entity644 was 5839.0 mg/day. @entity811 was present in 75% of @entity1 . @entity101 was reported in 34% of @entity1 . @entity810 , occurred in about 10% of @entity1 , and chronic loss of renal function was present in about 5% at diagnosis. CONCLUSIONS: @entity12042 is a disease of increasing incidence. The forms of clinical presentation proved to be variable, but the presence of @entity644 or @entity1985 in elderly @entity1 should always prompt the suspicion of @entity12042 and is a formal indication of renal biopsy.

title: Epidemiological, clinical and laboratorial profile of XXXX : a 12-year retrospective study of 37 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity12042 :: ('MESH:C538249', 'Disease') :: ['Renal amyloidosis', 'renal amyloidosis']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertension']

entities_list: @entity2783 :: ('MESH:D000686', 'Disease') :: ['AL', 'amyloidosis']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['Acute renal failure']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['nephrotic syndrome']

entities_list: @entity811 :: ('MESH:D006417', 'Disease') :: ['Hematuria']

answer: @entity12042 :: (MESH:C538249,Disease) :: ['renal amyloidosis']


abstract: BACKGROUND: To investigate and compare the period prevalences and incidences of optic disc @entity548 in normal tension @entity726 and primary @entity1538 . DESIGN: Hospital-based retrospective study. @entity1 : Four hundred and four @entity1 with normal tension @entity726 and 210 @entity1 with primary @entity1538 that underwent consecutive disc examinations at least quarterly for at least 1 year and stereoscopic optic disc photographs at intervals of 6 to 12 months between 1992 and 2007. METHODS: The period prevalence of disc @entity548 , gender predominance among @entity1 with disc @entity548 , and cumulative incidence of normal tension @entity726 and primary @entity1538 were compared. MAIN OUTCOME MEASURES: Period prevalence, cumulative incidence, and gender predominance of DHs in @entity1 with NTG and @entity725 . RESULTS: Three hundred and eighty-seven @entity1 (387 eyes) of normal tension @entity726 @entity1 and 205 @entity1 (205 eyes) of primary @entity1538 @entity1 were finally enrolled in the study. The period prevalence and incidence rates of the stereoscopic optic disc photograph-confirmed glaucomatous disc @entity548 were 33.3% (129/387), 0.46    0.18 times/year in the normal tension @entity726 group, and 17.6% (36/205), 0.34    0.23 times/year in the primary @entity1538 group, respectively. The absolute values and ratios of primary @entity1538 and normal tension @entity726 in period prevalences and incidence rates in the present study were higher than in previous studies. No significant difference in gender ratios was found between @entity1 that did or did not develop disc @entity548 for both types of @entity1538 (P > 0.05, respectively). CONCLUSIONS: The primary @entity1538 group had higher period prevalences and incidence rates of disc @entity548 than those reported previously. Disc @entity548 were found to develop independent of gender.

title: Period prevalence and incidence of optic disc @entity548 in normal tension @entity726 and primary XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity1538 :: ('MESH:D005902', 'Disease') :: ['open-angle glaucoma']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhage', 'haemorrhages']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

answer: @entity1538 :: (MESH:D005902,Disease) :: ['open-angle glaucoma']


abstract: BACKGROUND: To investigate and compare the period prevalences and incidences of optic disc @entity548 in normal tension @entity726 and primary @entity1538 . DESIGN: Hospital-based retrospective study. @entity1 : Four hundred and four @entity1 with normal tension @entity726 and 210 @entity1 with primary @entity1538 that underwent consecutive disc examinations at least quarterly for at least 1 year and stereoscopic optic disc photographs at intervals of 6 to 12 months between 1992 and 2007. METHODS: The period prevalence of disc @entity548 , gender predominance among @entity1 with disc @entity548 , and cumulative incidence of normal tension @entity726 and primary @entity1538 were compared. MAIN OUTCOME MEASURES: Period prevalence, cumulative incidence, and gender predominance of DHs in @entity1 with NTG and @entity725 . RESULTS: Three hundred and eighty-seven @entity1 (387 eyes) of normal tension @entity726 @entity1 and 205 @entity1 (205 eyes) of primary @entity1538 @entity1 were finally enrolled in the study. The period prevalence and incidence rates of the stereoscopic optic disc photograph-confirmed glaucomatous disc @entity548 were 33.3% (129/387), 0.46    0.18 times/year in the normal tension @entity726 group, and 17.6% (36/205), 0.34    0.23 times/year in the primary @entity1538 group, respectively. The absolute values and ratios of primary @entity1538 and normal tension @entity726 in period prevalences and incidence rates in the present study were higher than in previous studies. No significant difference in gender ratios was found between @entity1 that did or did not develop disc @entity548 for both types of @entity1538 (P > 0.05, respectively). CONCLUSIONS: The primary @entity1538 group had higher period prevalences and incidence rates of disc @entity548 than those reported previously. Disc @entity548 were found to develop independent of gender.

title: Period prevalence and incidence of optic disc @entity548 in normal tension XXXX and primary @entity1538 .

answer: @entity726 :: (MESH:D005901,Disease) :: ['glaucoma']


abstract: BACKGROUND: To investigate and compare the period prevalences and incidences of optic disc @entity548 in normal tension @entity726 and primary @entity1538 . DESIGN: Hospital-based retrospective study. @entity1 : Four hundred and four @entity1 with normal tension @entity726 and 210 @entity1 with primary @entity1538 that underwent consecutive disc examinations at least quarterly for at least 1 year and stereoscopic optic disc photographs at intervals of 6 to 12 months between 1992 and 2007. METHODS: The period prevalence of disc @entity548 , gender predominance among @entity1 with disc @entity548 , and cumulative incidence of normal tension @entity726 and primary @entity1538 were compared. MAIN OUTCOME MEASURES: Period prevalence, cumulative incidence, and gender predominance of DHs in @entity1 with NTG and @entity725 . RESULTS: Three hundred and eighty-seven @entity1 (387 eyes) of normal tension @entity726 @entity1 and 205 @entity1 (205 eyes) of primary @entity1538 @entity1 were finally enrolled in the study. The period prevalence and incidence rates of the stereoscopic optic disc photograph-confirmed glaucomatous disc @entity548 were 33.3% (129/387), 0.46    0.18 times/year in the normal tension @entity726 group, and 17.6% (36/205), 0.34    0.23 times/year in the primary @entity1538 group, respectively. The absolute values and ratios of primary @entity1538 and normal tension @entity726 in period prevalences and incidence rates in the present study were higher than in previous studies. No significant difference in gender ratios was found between @entity1 that did or did not develop disc @entity548 for both types of @entity1538 (P > 0.05, respectively). CONCLUSIONS: The primary @entity1538 group had higher period prevalences and incidence rates of disc @entity548 than those reported previously. Disc @entity548 were found to develop independent of gender.

title: Period prevalence and incidence of optic disc XXXX in normal tension @entity726 and primary @entity1538 .

answer: @entity548 :: (MESH:D006470,Disease) :: ['haemorrhage']


abstract: PURPOSE: Task Group 204 introduced @entity5562 ( @entity5562 ) as the @entity1 size metric used to correlate size-specific-dose-estimates. However, this size metric fails to account for @entity1 attenuation properties and has been suggested to be replaced by an attenuation-based size metric, water equivalent diameter (DW). The purpose of this study is to investigate different size metrics, @entity5562 , and water equivalent diameter, in combination with regional descriptions of scanner output to establish the most appropriate size metric to be used as a predictor for organ dose in tube current modulated CT exams. METHODS: 101 thoracic and 82 abdomen/pelvis scans from clinically indicated CT exams were collected retrospectively from a multidetector row CT (Sensation 64, Siemens Healthcare) with Institutional Review Board approval to generate voxelized @entity1 models. Fully irradiated organs (lung and breasts in thoracic scans and liver, kidneys, and spleen in abdominal scans) were segmented and used as tally regions in Monte Carlo simulations for reporting organ dose. Along with image data, raw projection data were collected to obtain tube current information for simulating tube current modulation scans using Monte Carlo methods. Additionally, previously described @entity1 size metrics [ @entity5562 , DW, and approximated water equivalent diameter (DWa)] were calculated for each @entity1 and reported in three different ways: a single value averaged over the entire scan, a single value averaged over the region of interest, and a single value from a location in the middle of the scan volume. Organ doses were normalized by an appropriate mAs weighted CTDIvol to reflect regional variation of tube current. Linear regression analysis was used to evaluate the correlations between normalized organ doses and each size metric. RESULTS: For the abdominal organs, the correlations between normalized organ dose and size metric were overall slightly higher for all three differently (global, regional, and middle slice) reported DW and DWa than they were for @entity5562 , but the differences were not statistically significant. However, for lung dose, computed correlations using water equivalent diameter calculated in the middle of the image data (DW,middle) and averaged over the low attenuating region of lung (DW,regional) were statistically significantly higher than correlations of normalized lung dose with @entity5562 . CONCLUSIONS: To conclude, @entity5562 and water equivalent diameter are very similar in abdominal regions; however, their difference becomes noticeable in lungs. Water equivalent diameter, specifically reported as a regional average and middle of scan volume, was shown to be better predictors of lung dose. Therefore, an attenuation-based size metric (water equivalent diameter) is recommended because it is more robust across different anatomic regions. Additionally, it was observed that the regional size metric reported as a single value averaged over a region of interest and the size metric calculated from a single slice/image chosen from the middle of the scan volume are highly correlated for these specific @entity1 models and scan types.

title: Attenuation-based size metric for estimating organ dose to XXXX undergoing tube current modulated CT exams.

entities_list: @entity5562 :: ('MESH:D015875', 'Disease') :: ['effective diameter', 'ED']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: @entity1 -reported outcome measures are increasingly used evaluating clinical care. Many measures used to assess operative hindfoot interventions vary in content, and some have not been psychometrically validated in this population. The purpose of this study was to compare measurement properties of 6 @entity1746 @entity1 -reported outcome measures, and to evaluate their reliability and validity in light of @entity1 ' preferences. METHODS: Cross-sectional survey of 42 preoperative and 100 postoperative @entity1 completed 6 @entity1746 outcome measures on 2 occasions: @entity10395 ( @entity10395 ), @entity3681 ( @entity3681 ), @entity1 -reported items of the @entity3681 ( @entity3681 ), Lower Extremity Functional Scale (LEFS), Western Ontario and McMaster Universities @entity571 Index (WOMAC), and the Short Musculoskeletal Function Assessment (SMFA), as well as measures of preference, and symptoms. RESULTS: Internal consistency was good to excellent for all scales and subscales (a = .84-.97; ICC [2,1] = .81-.96). Correlations between scales ranged from .50 (WOMACStiffness and FFIActivity Limitations) to .92 (LEFS and SMFAOverall, WOMACPain and AOSOverall, FFIOverall and AOFASOverall). Higher correlations occurred within instruments (r = .97 AOSPain and AOSOverall) and between similar subscales from different instruments (r = .91 WOMACPain and AOSPain). Construct validity showed moderate to high correlations to global ratings of @entity158 , Stiffness, and difficulty performing Daily Activities. The highest correlations (r > .75) occurred between @entity158 and AOSOverall (r = .84), stiffness and WOMACStiffness (r = .81), and Daily Activities and AOSDisability (r = .87). @entity1 rated instruments by preference. @entity10395 , WOMAC, LEFS, and SMFA rated favorably for length. @entity10395 , WOMAC, LEFS, and @entity3681 rated high for understandability. @entity10395 was rated by postoperative @entity1 as most likely to capture change due to surgery. SMFA rated the best overall. CONCLUSIONS: Direct comparison of instruments revealed similarity between scales in construct validity and reliability. @entity1 preferences supported the use of these scales. Foot-specific instruments offered no clear advantage over @entity1746 instruments. LEVEL OF EVIDENCE: Level II, prospective comparative study.

title: Reliability and Validity of 6 Measures of XXXX , Function, and Disability for Ankle Arthroplasty and Arthrodesis.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Patient']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['Osteoarthritis']

entities_list: @entity3681 :: ('MESH:D016512', 'Disease') :: ['American Orthopaedic Foot and Ankle Society Questionnaire', 'AOS', 'Ankle Osteoarthritis Scale', 'AOFAS']

entities_list: @entity1746 :: ('MESH:D020335', 'Disease') :: ['lower-extremity']

entities_list: @entity10395 :: ('MESH:D005534', 'Disease') :: ['FFI', 'Foot Function Index']

answer: @entity158 :: (MESH:D010146,Disease) :: ['Pain']


abstract: OBJECTIVES: Although successful airway management is essential for emergency @entity130 care, comprehensive studies are limited. We sought to characterise current @entity130 care practice of airway management in the @entity341 ( @entity341 ) in Japan. DESIGN: Analysis of data from a prospective, observational, multicentre registry-the Japanese Emergency Airway Network (JEAN) registry. SETTING: 13 @entity4207 and community @entity341 from different geographic regions across Japan. @entity1 : 723 @entity130 @entity1 who underwent emergency intubation from March 2010 through August 2012. OUTCOME MEASURES: ED characteristics, @entity1 and operator demographics, methods of airway management, intubation success or failure at each attempt and adverse events. RESULTS: A total of 723 @entity130 @entity1 who underwent emergency intubation were eligible for the analysis. Traumatic @entity1167 comprised 32.6% (95% CI 29.3% to 36.1%) of @entity1 . @entity1170 ( @entity1170 ) was the initial method chosen in 23.9% (95% CI 21.0% to 27.2%) of all @entity130 @entity1 and in 35.5% (95% CI 31.4% to 39.9%) of @entity1 without @entity1167 . Overall, intubation was successful in  <=3 attempts in 96% of @entity1 (95% CI 94.3% to 97.2%). There was a wide variation in the initial methods of intubation; @entity1170 as the initial method was performed in 0-50.9% of all @entity130 @entity1 among 12 @entity341 . Similarly, there was a wide variation in success rates and adverse event rates across the @entity341 . Success rates varied between 35.5% and 90.5% at the first attempt, and 85.1% and 100% within three attempts across the 12 @entity341 . CONCLUSIONS: In this multicentre prospective study in Japan, we observed a high overall success rate in airway management during @entity130 care. However, the methods of intubation and success rates were highly variable among hospitals.

title: @entity130 airway management in XXXX : a multicentre, prospective, observational study in Japan.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PARTICIPANTS']

entities_list: @entity1170 :: ('MESH:C564983', 'Disease') :: ['Rapid sequence intubation', 'RSI']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency departments', 'EDs']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest']

answer: @entity341 :: (MESH:D004630,Disease) :: ['emergency departments']


abstract: OBJECTIVES: Although successful airway management is essential for emergency @entity130 care, comprehensive studies are limited. We sought to characterise current @entity130 care practice of airway management in the @entity341 ( @entity341 ) in Japan. DESIGN: Analysis of data from a prospective, observational, multicentre registry-the Japanese Emergency Airway Network (JEAN) registry. SETTING: 13 @entity4207 and community @entity341 from different geographic regions across Japan. @entity1 : 723 @entity130 @entity1 who underwent emergency intubation from March 2010 through August 2012. OUTCOME MEASURES: ED characteristics, @entity1 and operator demographics, methods of airway management, intubation success or failure at each attempt and adverse events. RESULTS: A total of 723 @entity130 @entity1 who underwent emergency intubation were eligible for the analysis. Traumatic @entity1167 comprised 32.6% (95% CI 29.3% to 36.1%) of @entity1 . @entity1170 ( @entity1170 ) was the initial method chosen in 23.9% (95% CI 21.0% to 27.2%) of all @entity130 @entity1 and in 35.5% (95% CI 31.4% to 39.9%) of @entity1 without @entity1167 . Overall, intubation was successful in  <=3 attempts in 96% of @entity1 (95% CI 94.3% to 97.2%). There was a wide variation in the initial methods of intubation; @entity1170 as the initial method was performed in 0-50.9% of all @entity130 @entity1 among 12 @entity341 . Similarly, there was a wide variation in success rates and adverse event rates across the @entity341 . Success rates varied between 35.5% and 90.5% at the first attempt, and 85.1% and 100% within three attempts across the 12 @entity341 . CONCLUSIONS: In this multicentre prospective study in Japan, we observed a high overall success rate in airway management during @entity130 care. However, the methods of intubation and success rates were highly variable among hospitals.

title: XXXX airway management in @entity341 : a multicentre, prospective, observational study in Japan.

answer: @entity130 :: (MESH:D014947,Disease) :: ['Trauma']


abstract: @entity375 @entity7027 ( @entity7027 ) is determined by a wide variety of environmental and genetic factors. Nutrient limitation without @entity3147 , i.e. dietary restriction, expands @entity7027 through the control of nutrient signaling pathways, of which TOR/ @entity28555 has proven to be the most relevant, particularly under @entity1568 deprivation. The use of prototrophic wine @entity375 allows a better understanding of the role of @entity1568 in longevity in natural and more demanding environments, such as grape juice fermentation. We previously showed that acetyltransferase Gcn5, a member of the SAGA complex, has opposite effects on @entity7027 under laboratory and winemaking conditions, and is detrimental under the latter. Here we demonstrate that integrity of the SAGA complex is necessary for prolonged longevity, as its dismantling by @entity49008 deletion causes a drop in @entity7027 under both laboratory and winemaking conditions. The @entity28555   mutant is long-lived in synthetic SC medium, as expected, and the combined deletion of GCN5 partially suppresses this phenotype. However it is short-lived in grape juice, likely due to its low @entity1568 / @entity505 ratio. Therefore, unbalance of nutrients can be more relevant for life span than total amounts of them. Deletion of @entity12632 , which codes for a protein associated with Gcn5 and is a component of the mitochondrial retrograde signal, and which communicates mitochondrial dysfunction to the nucleus, is detrimental under laboratory, but not under winemaking conditions, where respiration seems not so relevant for longevity. Transcription factor @entity71906 was found to be a novel @entity7027 regulator @entity28555 -dependently.

title: Interplay among Gcn5, @entity28555 and Mitochondria during Chronological Aging of Wine XXXX Is Dependent on Growth Conditions.

entities_list: @entity7027 :: ('MESH:D057768', 'Disease') :: ['chronological life span', 'CLS']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['malnutrition']

entities_list: @entity375 :: ('4932', 'Species') :: ['yeast', 'Saccharomyces cerevisiae']

answer: @entity375 :: (4932,Species) :: ['Yeast']


abstract: @entity375 @entity7027 ( @entity7027 ) is determined by a wide variety of environmental and genetic factors. Nutrient limitation without @entity3147 , i.e. dietary restriction, expands @entity7027 through the control of nutrient signaling pathways, of which TOR/ @entity28555 has proven to be the most relevant, particularly under @entity1568 deprivation. The use of prototrophic wine @entity375 allows a better understanding of the role of @entity1568 in longevity in natural and more demanding environments, such as grape juice fermentation. We previously showed that acetyltransferase Gcn5, a member of the SAGA complex, has opposite effects on @entity7027 under laboratory and winemaking conditions, and is detrimental under the latter. Here we demonstrate that integrity of the SAGA complex is necessary for prolonged longevity, as its dismantling by @entity49008 deletion causes a drop in @entity7027 under both laboratory and winemaking conditions. The @entity28555   mutant is long-lived in synthetic SC medium, as expected, and the combined deletion of GCN5 partially suppresses this phenotype. However it is short-lived in grape juice, likely due to its low @entity1568 / @entity505 ratio. Therefore, unbalance of nutrients can be more relevant for life span than total amounts of them. Deletion of @entity12632 , which codes for a protein associated with Gcn5 and is a component of the mitochondrial retrograde signal, and which communicates mitochondrial dysfunction to the nucleus, is detrimental under laboratory, but not under winemaking conditions, where respiration seems not so relevant for longevity. Transcription factor @entity71906 was found to be a novel @entity7027 regulator @entity28555 -dependently.

title: Interplay among Gcn5, XXXX and Mitochondria during Chronological Aging of Wine @entity375 Is Dependent on Growth Conditions.

answer: @entity28555 :: (856612(Tax:4932),Gene) :: ['Sch9']


abstract: This study attempted to elucidate the etiology of @entity5 by examining its association with a number of factors in a relatively unselected group of @entity1 . In 1963, a cytologic screening program was undertaken in Washington County, Maryland. The irrigation smear method was used. The final study group of 4341 was 46% of all white @entity1 aged 30-45 years enumerated in the census. Of the 4290 satisfactory smears, 46 were positive or suspicious. Subsequent investigation confirmed 31 cases of which 28 were at Stage 0 and 3 were invasive @entity189 . Of 15 with suspicious cytologic findings 6 had confirmed findings, all of which were at Stage 0. @entity1 who were never married had no confirmed cases. Currently-married @entity1 had lower rates than @entity1 whose marriages had been disrupted. Those who were married at age 16 or earlier had higher rates of @entity5 as did those from lower socioeconomic levels. Having had multiple sex partners was associated with an increased risk of developing @entity5 . Smokers had slightly higher rates than nonsmokers. Trichomonas @entity277 was associated with higher rates. Findings indicate that trichomoniasis and @entity5 are both associated with sexual activity.

title: Relation of XXXX as determined by a screening program.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cervical cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma of the cervix']

entities_list: @entity277 :: ('MESH:D013984', 'Disease') :: ['vaginali s infestation']

answer: @entity5 :: (MESH:D009369,Disease) :: ['various epidemiologic factors to cervical cancer']


abstract: UNASSIGNED: The therapeutic spectrum of this disorder consists of medical therapy, @entity384 , endoscopic Botox injection, open or laparoscopic @entity418 , and most recently transesophageal endoscopic myotomy ( @entity20801 peroral endoscopic myotomy). The most important requirement is a well-experienced team in interventional flexible endoscopy. The endoscopist as well as the assisting staff should have experience in advanced therapeutic endoscopic techniques and hemostasis to handle all necessary endoscopic instruments such as injection needles, needle knife, triangle knife, coagulation graspers, and endoscopic clip handling and closures. In addition, advanced surgical and especially laparoscopic skills and experience as well as surgical knowledge about @entity1208 must be available in case of conversion and/or consultation. Prior to this procedure, the @entity1 undergoes a detailed diagnostic work-up to confirm the diagnosis of @entity1318 . The procedures are performed in general anesthesia. The @entity1 is brought in a supine position, and the abdomen is free for inspection and palpation during the procedure. The myotomy can be performed in different locations around the esophageal circumference. In Europe, several centers with large experience in @entity1208 , laparoscopy, and especially advanced interventional endoscopy have started to introduce this @entity20801 -technique in their clinical practice. Initial success and low complication rates are quite promising and show a great future perspective for this technique. In the USA, @entity20801 is a procedure with a substantial increase in numbers performed in the past years with a low complication rate. The largest series are performed in Asia with a great clinical success. The perspective of @entity20801 may be the lesser access @entity130 . Its potential can be also realized in Redo cases, where experienced centers have initial experience with @entity20801 after @entity20801 and @entity20801 after LHMD.

title: The Potential and Perspective of Peroral Endoscopic Esophageal Myotomy for XXXX .

entities_list: @entity1318 :: ('MESH:D004931', 'Disease') :: ['achalasia']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['endoscopic balloon dilatation']

entities_list: @entity1208 :: ('MESH:D004935', 'Disease') :: ['esophageal disease']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['cardia myotomy']

answer: @entity1318 :: (MESH:D004931,Disease) :: ['Achalasia']


abstract: BACKGROUND: Surgical audit is an essential task for the estimation of postoperative outcome and comparison of quality of care. Previous studies on surgical audits focused on short-term outcomes, such as postoperative mortality. We propose a surgical audit evaluating long-term outcome following @entity14 surgery. The predictive model for this audit is designated as 'Estimation of Postoperative Overall Survival for @entity14 (EPOS-CC)'. METHODS: Thirty-one @entity5 -related and physiological variables were prospectively collected in 889 @entity1 undergoing elective resection for @entity14 between April 2005 and April 2007 in 16 Japanese hospitals. Postoperative overall survival was assessed over a 5-years period. The EPOS-CC score was established by selecting significant variables in a uni- and multivariate analysis and allocating a risk-adjusted multiplication factor to each variable using Cox regression analysis. For validation, the EPOS-CC score was compared to the predictive power of UICC stage. Inter-hospital variability of the observed-to-estimated 5-years survival was assessed to estimate quality of care. RESULTS: Among the 889 @entity1 , 804 (90  %) completed the 5-years follow-up. Univariate analysis displayed a significant correlation with 5-years survival for 14 physiological and nine @entity5 -related variables (p  <  0.005). Highly significant p-values below 0.0001 were found for age, ASA score, severe @entity358 , respiratory history, performance status, @entity4988 , alteration of hemoglobin, serum @entity1372 level, and for all histological variables except @entity5 location. Age, @entity2802 stage, lymphatic invasion, performance status, and serum @entity1372 level were independent variables in the multivariate analysis and were entered the EPOS-CC model for the prediction of survival. Risk-adjusted multiplication factors between 1.5 (distant metastasis) and 0.16 (serum @entity1372 level) were accorded to the different variables. The predictive power of EPOS-CC was superior to the one of UICC stage; area under the curve 0.87, 95  % CI 0.85-0.90 for EPOS-CC, and 0.80, 0.76-0.83 for UICC stage, p  <  0.001. Quality of care did not differ between hospitals. CONCLUSIONS: The EPOS-CC score including the independent variables age, performance status, serum @entity1372 level, @entity2802 stage, and lymphatic invasion is superior to the UICC stage in the prediction of 5-years overall survival. This higher accuracy might be explained by the inclusion of physiological factors, thus also taking non- @entity5 -associated deaths into account. Furthermore, EPOS-CC score may compare quality of care among different institutions. Future studies are necessary to further evaluate this score and help improving the prediction of long-term survival following @entity14 surgery.

title: The EPOS-CC Score: An Integration of Independent, Tumor- and @entity1 -Associated Risk Factors to Predict 5-years Overall Survival Following XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4988 :: ('MESH:D034141', 'Disease') :: ['hypoalbuminemia']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary disease']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal Cancer', 'colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer Surgery']


abstract: BACKGROUND: Surgical audit is an essential task for the estimation of postoperative outcome and comparison of quality of care. Previous studies on surgical audits focused on short-term outcomes, such as postoperative mortality. We propose a surgical audit evaluating long-term outcome following @entity14 surgery. The predictive model for this audit is designated as 'Estimation of Postoperative Overall Survival for @entity14 (EPOS-CC)'. METHODS: Thirty-one @entity5 -related and physiological variables were prospectively collected in 889 @entity1 undergoing elective resection for @entity14 between April 2005 and April 2007 in 16 Japanese hospitals. Postoperative overall survival was assessed over a 5-years period. The EPOS-CC score was established by selecting significant variables in a uni- and multivariate analysis and allocating a risk-adjusted multiplication factor to each variable using Cox regression analysis. For validation, the EPOS-CC score was compared to the predictive power of UICC stage. Inter-hospital variability of the observed-to-estimated 5-years survival was assessed to estimate quality of care. RESULTS: Among the 889 @entity1 , 804 (90  %) completed the 5-years follow-up. Univariate analysis displayed a significant correlation with 5-years survival for 14 physiological and nine @entity5 -related variables (p  <  0.005). Highly significant p-values below 0.0001 were found for age, ASA score, severe @entity358 , respiratory history, performance status, @entity4988 , alteration of hemoglobin, serum @entity1372 level, and for all histological variables except @entity5 location. Age, @entity2802 stage, lymphatic invasion, performance status, and serum @entity1372 level were independent variables in the multivariate analysis and were entered the EPOS-CC model for the prediction of survival. Risk-adjusted multiplication factors between 1.5 (distant metastasis) and 0.16 (serum @entity1372 level) were accorded to the different variables. The predictive power of EPOS-CC was superior to the one of UICC stage; area under the curve 0.87, 95  % CI 0.85-0.90 for EPOS-CC, and 0.80, 0.76-0.83 for UICC stage, p  <  0.001. Quality of care did not differ between hospitals. CONCLUSIONS: The EPOS-CC score including the independent variables age, performance status, serum @entity1372 level, @entity2802 stage, and lymphatic invasion is superior to the UICC stage in the prediction of 5-years overall survival. This higher accuracy might be explained by the inclusion of physiological factors, thus also taking non- @entity5 -associated deaths into account. Furthermore, EPOS-CC score may compare quality of care among different institutions. Future studies are necessary to further evaluate this score and help improving the prediction of long-term survival following @entity14 surgery.

title: The EPOS-CC Score: An Integration of Independent, Tumor- and XXXX -Associated Risk Factors to Predict 5-years Overall Survival Following @entity14 .

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: INTRODUCTION: The aim of this study was to investigate the association between alcoholic and non-alcoholic beverages and knee or @entity570 ( @entity571 ). METHODS: We conducted a case-control study of Caucasian @entity1 and @entity1 aged 45 to 86 years of age from Nottingham, UK. Cases had clinically severe symptoms and radiographic knee or hip @entity571 ; controls had no symptoms and no radiographic knee or hip @entity571 . Exposure information was sought using interview-based questionnaires and a semi-quantitative food frequency questionnaire to assess beverage consumption at ages 21 to 50 years. Odds ratios (ORs), adjusted ORs (aORs), 95% confidence intervals (CI) and P values were estimated using logistic regression models. RESULTS: A total of 1,001 knee @entity571 , 993 hip @entity571 and 933 control @entity1 were included in the study. Increasing beer consumption was associated with an increasing risk of @entity571 (P for trend <=0.001). Compared to those who did not consume beer, aORs for @entity1 who consumed 20 or more servings of beer were 1.93 (95% CI 1.26 to 2.94) and 2.15 (95% CI 1.45 to 3.19) for knee @entity571 and hip @entity571 , respectively. In contrast, increasing levels of wine consumption were associated with decreased likelihood of knee @entity571 (P for trend<0.001). Compared to those who did not consume wine, aOR for knee @entity571 among those who consumed 4 to 6 glasses of wine per week and >= 7 glasses of wine per week was 0.55 (95% CI 0.34 to 0.87) and 0.48 (95% CI 0.29 to 0.80), respectively. No association was identified between non-alcoholic beverages and knee or hip @entity571 . CONCLUSIONS: Beer consumption appears to be a risk factor for knee and hip @entity571 whereas consumption of wine has a negative association with knee @entity571 . The mechanism behind these findings is speculative but warrants further study.

title: Beer and wine consumption and risk of knee or XXXX : a case control study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'people', 'men']

entities_list: @entity570 :: ('MESH:D015207', 'Disease') :: ['hip osteoarthritis']

answer: @entity570 :: (MESH:D015207,Disease) :: ['hip osteoarthritis']


abstract: UNASSIGNED: @entity1150 ( @entity1150 ) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of @entity10013 on EPCs function and venous @entity715 resolution. We demonstrated that overexpression of @entity10013 enhanced EPCs' migration and tubulogenic activity in vitro, and promoted EPCs' homing and @entity715 resolving in vivo. Moreover, we identified that @entity10013 directly targeted @entity8569 and affected @entity10412 /Akt signaling axis. Overall, our findings demonstrated that @entity10013 promoted EPCs function through suppressing @entity8569 expression and modulation of @entity10013 may represent a potential therapeutic intervention for treating @entity1150 . J. Cell. Biochem. 116: 1613-1623, 2015.    2015 Wiley Periodicals, Inc.

title: Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in @entity1150 via Its Target XXXX .

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['Deep vein thrombosis', 'DVT']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

answer: @entity8569 :: (5296,Gene) :: ['PIK3R2']


abstract: UNASSIGNED: @entity1150 ( @entity1150 ) is a common complication of surgery. Endothelial progenitor cells (EPCs) are recruited into resolving venous thrombi. In this report, we investigated the effects of @entity10013 on EPCs function and venous @entity715 resolution. We demonstrated that overexpression of @entity10013 enhanced EPCs' migration and tubulogenic activity in vitro, and promoted EPCs' homing and @entity715 resolving in vivo. Moreover, we identified that @entity10013 directly targeted @entity8569 and affected @entity10412 /Akt signaling axis. Overall, our findings demonstrated that @entity10013 promoted EPCs function through suppressing @entity8569 expression and modulation of @entity10013 may represent a potential therapeutic intervention for treating @entity1150 . J. Cell. Biochem. 116: 1613-1623, 2015.    2015 Wiley Periodicals, Inc.

title: Upregulation of MicroRNA-126 Contributes to Endothelial Progenitor Cell Function in XXXX via Its Target @entity8569 .

answer: @entity1150 :: (MESH:D020246,Disease) :: ['Deep Vein Thrombosis']


abstract: PURPOSE: To determine the effect of 1% @entity14433 on the refractive status of @entity1 aged 4 to 18 years. METHODS: Using a random cluster sampling in a cross-sectional school-based study design, @entity1 with an age of 4-18 years were selected from kindergardens, primary schools, junior and senior high schools in a rural county and a city. Auto-refractometry was performed before and after inducing cycloplegia which was achieved by 1% cyclopentolate eye drops. RESULTS: Out of 6364 eligible @entity1 , data of 5999 (94.3%) @entity1 were included in the statistical analysis. Mean age was 10.0  3.3 years (range: 4-18 years). Mean difference between cycloplegic and non-cycloplegic @entity2516 (DIFF) was 0.78  0.79D (median: 0.50D; range: -1.00D to +10.75D). In univariate analysis, DIFF decreased significantly with older age (P<0.001;correlation coefficient r:-0.24), more hyperopic non-cycloplegic @entity2516 (P<0.001;r = 0.13) and more @entity2516 (P<0.001;r = 0.49). In multivariate analysis, higher DIFF was associated with higher cycloplegic @entity2516 (P<0.001; standardized regression coefficient beta:0.50; regression coefficient B: 0.19; 95% confidence interval (CI): 0.18, 0.20), followed by lower intraocular pressure (P<0.001; beta: -0.06; B: -0.02; 95%CI: -0.03, -0.01), rural region of habitation (P = 0.001; beta: -0.04; B: -0.07; 95%CI: -0.11, -0.03), and, to a minor degree, with age (P = 0.006; beta: 0.04; B: 0.009; 95%CI: 0.003, 0.016). 66.4% of all eyes with non-cycloplegic @entity1714 ( <=-0.50D) remained myopic after cycloplegia while the remaining 33.6% of eyes became emmetropic (18.0%) or hyperopic (15.7%) under cycloplegia. Prevalence of emmetropia decreased from 37.5% before cycloplegia to 19.8% after cycloplegia while the remaining eyes became hyperopic under cycloplegia. CONCLUSIONS: The error committed by using non-cycloplegic versus cycloplegic refractometry in @entity1 with mid to dark-brown iris color decreased with older age, and in parallel manner, with more @entity2516 . Non-cycloplegic refractometric measures lead to a misclassification of @entity2516 in a significant proportion of @entity1 .

title: Effect of cycloplegia on the refractive status of XXXX : the shandong @entity1 eye study.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity2516 :: ('MESH:D012030', 'Disease') :: ['refractive error', 'hyperopic cycloplegic refractive error', 'myopic cycloplegic refractive error']

entities_list: @entity14433 :: ('MESH:D003519', 'Chemical') :: ['cyclopentolate']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: PURPOSE: To determine the effect of 1% @entity14433 on the refractive status of @entity1 aged 4 to 18 years. METHODS: Using a random cluster sampling in a cross-sectional school-based study design, @entity1 with an age of 4-18 years were selected from kindergardens, primary schools, junior and senior high schools in a rural county and a city. Auto-refractometry was performed before and after inducing cycloplegia which was achieved by 1% cyclopentolate eye drops. RESULTS: Out of 6364 eligible @entity1 , data of 5999 (94.3%) @entity1 were included in the statistical analysis. Mean age was 10.0  3.3 years (range: 4-18 years). Mean difference between cycloplegic and non-cycloplegic @entity2516 (DIFF) was 0.78  0.79D (median: 0.50D; range: -1.00D to +10.75D). In univariate analysis, DIFF decreased significantly with older age (P<0.001;correlation coefficient r:-0.24), more hyperopic non-cycloplegic @entity2516 (P<0.001;r = 0.13) and more @entity2516 (P<0.001;r = 0.49). In multivariate analysis, higher DIFF was associated with higher cycloplegic @entity2516 (P<0.001; standardized regression coefficient beta:0.50; regression coefficient B: 0.19; 95% confidence interval (CI): 0.18, 0.20), followed by lower intraocular pressure (P<0.001; beta: -0.06; B: -0.02; 95%CI: -0.03, -0.01), rural region of habitation (P = 0.001; beta: -0.04; B: -0.07; 95%CI: -0.11, -0.03), and, to a minor degree, with age (P = 0.006; beta: 0.04; B: 0.009; 95%CI: 0.003, 0.016). 66.4% of all eyes with non-cycloplegic @entity1714 ( <=-0.50D) remained myopic after cycloplegia while the remaining 33.6% of eyes became emmetropic (18.0%) or hyperopic (15.7%) under cycloplegia. Prevalence of emmetropia decreased from 37.5% before cycloplegia to 19.8% after cycloplegia while the remaining eyes became hyperopic under cycloplegia. CONCLUSIONS: The error committed by using non-cycloplegic versus cycloplegic refractometry in @entity1 with mid to dark-brown iris color decreased with older age, and in parallel manner, with more @entity2516 . Non-cycloplegic refractometric measures lead to a misclassification of @entity2516 in a significant proportion of @entity1 .

title: Effect of cycloplegia on the refractive status of @entity1 : the shandong XXXX eye study.

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: @entity12316 ( @entity12316 ) temporary abutments have been recently introduced for making implant-supported provisional single crowns. Little information is available in the dental literature on the durability of provisional implant-supported restorations. PURPOSE: The objectives of this study were to evaluate the @entity174 strength of implant-supported composite resin crowns on PEEK and solid @entity702 temporary abutments, and to analyze the failure types. MATERIAL AND METHODS: Three types of provisional abutments, RN synOcta Temporary Meso Abutment (PEEK; Straumann), RN synOcta @entity702 Post for Temporary Restorations (Straumann), and Temporary Abutment Engaging NobRplRP (Nobel Biocare) were used, and provisional screw-retained crowns using composite resin (Solidex) were fabricated for four different locations in the maxilla. The specimens were tested in a universal testing machine at a crosshead speed of 1 mm/minute until @entity174 occurred. The failure types were analyzed and further categorized as irreparable (Type 1) or reparable (Type 2). RESULTS: No significant difference was found between different abutment types. Only for the position of the maxillary central incisor, composite resin crowns on PEEK temporary abutments showed significantly lower (p < 0.05) @entity174 strength (95    21 N) than those on @entity702 temporary abutments (1,009    94 N). The most frequently experienced failure types were @entity174 (75 out of 104), followed by screw loosening (18 out of 104). According to reparability, the majority of the specimens were classified as Type 1 (82 out of 104). @entity177 were not often observed (22 out of 104). CONCLUSIONS: Provisional crowns on PEEK abutments showed similar @entity174 strength as @entity702 temporary abutments except for central incisors. Maxillary right central incisor composite resin crowns on PEEK temporary abutments fractured below the mean anterior masticatory loading forces reported to be approximately 206 N.

title: Fracture strength and failure mode of maxillary implant-supported provisional single crowns: a comparison of composite resin crowns fabricated directly over PEEK abutments and solid XXXX abutments.

entities_list: @entity702 :: ('MESH:D014025', 'Chemical') :: ['titanium', 'Titanium']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['Type 2 failures']

entities_list: @entity12316 :: ('MESH:C063834', 'Chemical') :: ['Polyetheretherketone', 'PEEK']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture', 'cohesive fractures of the composite resin crowns']

answer: @entity702 :: (MESH:D014025,Chemical) :: ['titanium']


abstract: INTRODUCTION: @entity306 has been paid to the psychological status of @entity249 @entity1 from developing countries who have been traditionally stigmatized as feeble and ineffective. AIM: The aim of this study is to evaluate the prevalence of @entity308 and its socio-demographic correlates in a sample of Iranian @entity249 @entity1 . METHODS: One hundred and fourteen @entity249 @entity1 filled out the 21-item Beck @entity308 Inventory. @entity1 who scored >=  17 were considered @entity308 and those with the score  <= 16 were assumed to be nondepressed. MAIN OUTCOME MEASURES: (i) Comparison between @entity308 and non- @entity308 @entity1 regarding age, education level, economic status, ethnicity, age at time of marriage, duration, and @entity249 and regular cigarette smoking. (ii) Independent risk factors for @entity308 . RESULTS: The mean age of @entity1 was 34.1    7.1 years. The diagnosis of @entity308 was made in 42.9% of @entity249 @entity1 . Current age, age at marriage, economic status, and @entity249 were not statistically different between two groups (P > 0.05). Statistically significant association was detected between @entity308 symptoms and education (P < 0.001), cigarette smoking (P < 0.008), and duration of @entity249 (P < 0.03). In an adjusted multiple regression model, education (odds ratio [OR] 0.2; confidence interval [CI] 0.06-0.5, P < 0.003), ethnicity (OR 4.5; CI 1.5-13.3, P < 0.006), and cigarette smoking (OR 5.1; CI 1.4-18.5, P < 0.01) retained their significance, while duration of @entity249 lost its power. CONCLUSION: @entity308 among Iranian @entity249 @entity1 is remarkably higher in comparison with Western countries. Azaris, cigarette smokers, and individuals with low educational level are at higher risk of developing @entity308 among @entity249 @entity1 .

title: Male infertility and XXXX : a neglected problem in the Middle East.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Men', 'men']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility', 'type of infertility', 'infertile']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depressed', 'depression']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['Little attention']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: UNASSIGNED: The ubiquitin proteasome system in plants plays important roles in plant-microbe interactions and in immune responses to pathogens. We previously demonstrated that the @entity579 U-box E3 ligase SPL11 and its @entity958 ortholog @entity71907 negatively regulate @entity204 ( @entity204 ) and defense response. However, the components involved in the SPL11/ @entity71907 -mediated @entity204 and immune signaling pathway remain unknown. In this study, we report that SPL11-interacting Protein 6 (SPIN6) is a Rho GTPase-activating protein (RhoGAP) that interacts with SPL11 in vitro and in vivo. SPL11 ubiquitinates SPIN6 in vitro and degrades SPIN6 in vivo via the 26S proteasome-dependent pathway. Both RNAi silencing in transgenic @entity579 and knockout of Spin6 in a T-DNA insertion mutant lead to @entity204 and increased resistance to the @entity579 blast pathogen @entity8812 and the bacterial blight pathogen @entity16990 . oryzae. The levels of reactive @entity26 species and defense-related gene expression are significantly elevated in both the Spin6 RNAi and mutant plants. Strikingly, SPIN6 interacts with the small GTPase OsRac1, catalyze the @entity3007 -bound OsRac1 into the @entity3006 -bound state in vitro and has GAP activity towards OsRac1 in @entity579 cells. Together, our results demonstrate that the RhoGAP SPIN6 acts as a linkage between a U-box E3 ligase-mediated ubiquitination pathway and a small GTPase-associated defensome system for plant immunity.

title: The RhoGAP SPIN6 Associates with SPL11 and OsRac1 and Negatively Regulates Programmed Cell Death and Innate Immunity in XXXX .

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis']

entities_list: @entity16990 :: ('347', 'Species') :: ['Xanthomonas oryzae pv']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity8812 :: ('318829', 'Species') :: ['Magnaporthe oryzae']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['PCD', 'programmed cell death']

answer: @entity579 :: (4530,Species) :: ['Rice']


abstract: INTRODUCTION: @entity8052 is a serious complication of pregnancy. We describe a case leading to uterine @entity397 associated with massive @entity548 . CASE PRESENTATION: A 34-year-old Caucasian Albanian @entity1 , gravida 2, para 1, was admitted to the emergency department of our hospital for acute @entity490 associated with profound secondary @entity417 . An anatomopathological diagnosis of @entity8052 destruens was made. An urgent hysterectomy was performed after resuscitation procedures, applied due to the severe @entity417 and the abdominal drama accompanying the case. Intra-operatively, a uterus-saving procedure was found to be impossible, and hysterectomy remained the only surgical option. The uterine structures were sent for further microscopic evaluation. On histological examination, deep trophoblastic infiltration of the uterine wall was observed, justifying the surgeon's decision. Our @entity1 received blood transfusions and antibiotics. Her sutures were removed on the eighth postoperative day and she was discharged the following day in a stable condition. CONCLUSION: This case, describing a @entity1 with uterine @entity397 and massive @entity548 , illustrates a serious and potentially fatal complication of @entity5030 . In such cases, surgery is essential, and hysterectomy may be the only viable option.

title: XXXX causing hemoperitoneum in the 26th week of pregnancy: a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intra-abdominal hemorrhage', 'hemorrhage']

entities_list: @entity5030 :: ('MESH:D010923', 'Disease') :: ['placenta previa']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity8052 :: ('MESH:D010921', 'Disease') :: ['placenta increta', 'Placenta increta']

answer: @entity8052 :: (MESH:D010921,Disease) :: ['Placenta increta']


abstract: High-resolution electrophoretic methods and sensitive protein-detection techniques permit new approaches to understanding and diagnosis of the @entity2246 . These approaches encompass: the search for protein alterations that represent primary mutations effects; observation of alterations in protein patterns due to secondary effects, as might occur in major metabolic pathway abnormalities; and identification of protein polymorphisms that are genetically linked to an @entity14079 . With the aid of computer analysis of the electrophoretograms, all three approaches are being developed. Protein density and position are evaluated with an interactive computer program that requires that gel polypeptides be indexed by the investigator. Proteins on the gels are made visible with an inexpensive, rapid @entity575 stain, which can be used quantitatively. The @entity24901 , one of a few @entity146 for which the molecular defect is known, was chosen for study with these techniques. Four hundred proteins were analyzed for positional or quantitative variation. Eleven significant (2p less than 0.01) quantitative differences were found in autoradiograms from gels of phytohemagglutinin-stimulated lymphocytes. Specific patterns of polypeptide variation are now being sought in an expanded clinical study primarily focusing on @entity2033 . Large studies are required to establish the specificity of observed alterations. As the number and variety of analyses increase, a correlative catalog of molecular variation and polymorphism will be generated.

title: Quantitative two-dimensional protein electrophoresis for studies of XXXX .

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['neuropsychiatric diseases']

entities_list: @entity2033 :: ('MESH:D006816', 'Disease') :: ["Huntington's disease"]

entities_list: @entity14079 :: ('MESH:D020739', 'Disease') :: ['inborn metabolic disease']

entities_list: @entity24901 :: ('MESH:D007926', 'Disease') :: ['Lesch-Nyhan syndrome']

entities_list: @entity2246 :: ('MESH:D008661', 'Disease') :: ['inborn errors of metabolism']

answer: @entity2246 :: (MESH:D008661,Disease) :: ['inborn errors of metabolism']


abstract: Feed costs substantially affect the efficiency of poultry operations, justifying genetic improvement of feed utilization by selection. The current research was conducted to estimate genetic variance for the 4-wk feed conversion ratio (FCR) and its genetic correlations with BW, @entity1017 ( @entity2883 ), feed intake (FI), and @entity41 ( @entity41 ) in @entity5872 . The data analyzed originated from a line selected for low FCR for 3 generations. In each generation, 35 sires and 70 dams were used as parents for the next generation. Body weight and @entity2883 were recorded on a total of 1,226 individuals, whereas FCR, @entity41 , and FI were recorded on 505 family groups. The results showed that heritability estimates (  SE) of BW at 28 d of age and @entity2883 between 7 and 28 d of age were 0.22    0.05 and 0.28    0.06, respectively. For FI, FCR, and @entity41 , significant genetic variances were estimated. Genetic correlations of FCR between 7 and 28 d of age with @entity2883 and FI between 7 and 28 d of age were -0.45    0.09 and 0.24    0.08, respectively. This implies that a low FCR is genetically related to a high @entity2883 and low FI. The genetic correlation between FCR from 7 to 28 d of age and @entity41 from 7 to 28 d of age was 0.26    0.08, indicating that the 2 alternative feed efficiency traits are genetically different traits, and that the correlated genetic response in one of them in response to selection on the other is likely to be only moderate. Genetic correlations of @entity41 from 7 to 28 d of age with @entity2883 and FI between 7 and 28 d of age were 0.08    0.04 and 0.74    0.11, respectively. This reflects the fact that @entity41 is phenotypically independent of @entity2883 , which tends to make the genetic correlation between @entity41 and @entity2883 low as well. In conclusion, all the traits analyzed displayed significant genetic variance, allowing their genetic improvement by selection, yet the alternative feed utilization traits, FCR and @entity41 , displayed different genetic characteristics.

title: Genetic parameters for feed utilization traits in XXXX .

entities_list: @entity5872 :: ('93934', 'Species') :: ['Japanese quail']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['RFI', 'residual feed intake']

answer: @entity5872 :: (93934,Species) :: ['Japanese quail']


abstract: OBJECTIVE: To compare the effectiveness of elective single embryo transfer versus double embryo transfer on the outcomes of live birth, multiple live birth, miscarriage, @entity600 , term singleton birth, and low birth weight after fresh embryo transfer, and on the outcomes of cumulative live birth and multiple live birth after fresh and frozen embryo transfers. DESIGN: One stage meta-analysis of individual @entity1 data. DATA SOURCES: A systematic review of English and non-English articles from Medline, Embase, and the Cochrane Central Register of Controlled Trials (up to 2008). Additional studies were identified by contact with clinical experts and searches of bibliographies of all relevant primary articles. Search terms included embryo transfer, randomised controlled trial, controlled clinical trial, single embryo transfer, and double embryo transfer. Review methods Comparisons of the clinical effectiveness of cleavage stage (day 2 or 3) elective single versus double embryo transfer after fresh or frozen @entity52 ( @entity52 ) or intracytoplasmic sperm injection (ICSI) treatments were included. Trials were included if the intervention differed only in terms of the intended number of embryos to be transferred. Trials that involved only blastocyst (day five) transfers were excluded. RESULTS: Individual @entity1 data were received for every @entity1 recruited to all eight eligible trials (n=1367). A total of 683 and 684 @entity1 randomised to the single and double embryo transfer arms, respectively, were included in the analysis. Baseline characteristics in the two groups were comparable. The overall live birth rate in a fresh @entity52 cycle was lower after single (181/683, 27%) than double embryo transfer (285/683, 42%) (adjusted odds ratio 0.50, 95% confidence interval 0.39 to 0.63), as was the multiple birth rate (3/181 (2%) v 84/285 (29%)) (0.04, 0.01 to 0.12). An additional frozen single embryo transfer, however, resulted in a cumulative live birth rate not significantly lower than the rate after one fresh double embryo transfer (132/350 (38%) v 149/353 (42%) (0.85, 0.62 to 1.15), with a minimal cumulative risk of multiple birth (1/132 (1%) v 47/149 (32%)). The odds of a term singleton birth (that is, over 37 weeks) after elective single embryo transfer was almost five times higher than the odds after double embryo transfer (4.93, 2.98 to 8.18). CONCLUSIONS: Elective single embryo transfer results in a higher chance of delivering a term singleton live birth compared with double embryo transfer. Although this strategy yields a lower pregnancy rate than a double embryo transfer in a fresh @entity52 cycle, this difference is almost completely overcome by an additional frozen single embryo transfer cycle. The multiple pregnancy rate after elective single embryo transfer is comparable with that observed in spontaneous pregnancies.

title: Clinical effectiveness of elective single versus double embryo transfer: meta-analysis of individual XXXX data from randomised trials.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patient']

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilisation']

entities_list: @entity600 :: ('MESH:D000014', 'Disease') :: ['preterm birth']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: PURPOSE: To compare postoperative changes in apparent photopic and mesopic pupil size and centration in relation to @entity267 landmarks after @entity231 surgery. SETTING: LaserVision.gr Clinical and Research Eye Institute, Athens, Greece. DESIGN: Prospective consecutive case study. METHODS: Pupils were imaged for pupil size and corneal vertex location before and 1-month after @entity231 surgery. Digital analysis of pupil images was used to determine the Cartesian coordinates (nasal-temporal, horizontal @entity2270 , superior-inferior, vertical @entity2270 ) of the first Purkinje reflection point  (approximating the corneal intersection of the @entity227 [corneal vertex]) to the pupil geometric center (approximating the corneal intersection of the line of sight [corneal apex]). Pupil size changes were measured, and the correlation between vertex-to-apex shift changes and postoperative pupil centroid shift was evaluated. RESULTS: The study evaluated 40 eyes. The pupil size (diameter) change corresponded to a relative reduction of -9.8% for photopic pupils and -9.1% for mesopic pupils; the difference was statistically significant (P = .045 and P = .011, respectively). Also, there was a reduction in the centroid shift (all eyes) from a mean of 0.12  mm preoperatively to 0.05  mm postoperatively as a result of the postoperative minus temporal horizontal difference between the corneal vertex and the apex. CONCLUSIONS: Cataract extraction surgery appears to affect pupil size and centration. Specifically, a smaller pupil and less temporal shift were recorded. These data may have clinical relevance in targeted intraoperative intraocular lens centration. FINANCIAL DISCLOSURE: Dr. Kanellopoulos is a consultant to Alcon Surgical, Inc., Wavelight Laser Technologie AG, Allergan, Avedro, Inc., and i-Optics Corp. No author has a financial or proprietary interest in any material or method mentioned.

title: Digital pupillometry and centroid shift changes after XXXX surgery.

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual axis']

entities_list: @entity267 :: ('MESH:D065306', 'Disease') :: ['cornea reflection']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract']

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']


abstract: PURPOSE: To compare the @entity158 , @entity148 , undesired movement, and cooperation between @entity1 receiving oral @entity3175 or intravenous (IV) @entity1363 for conscious sedation during @entity231 surgery under topical anesthesia. SETTING: Ambulatory surgical center, Honolulu, Hawaii, USA. DESIGN: Prospective randomized controlled trial. METHODS: @entity1 having first-time @entity231 extraction with topical anesthesia were randomized to receive sedation with oral @entity3175 30  minutes before surgery or IV @entity1363 immediately preceding surgery. The outcomes of @entity158 , @entity148 , undesired movement, and poor cooperation were observed by the surgeon and recorded during surgery. RESULTS: One hundred fifty-six @entity231 surgeries were included, 83 in the IV @entity1363 group and 73 in the oral @entity3175 group. Twenty-four @entity1 (29%) in the IV group and 7 @entity1 (10%) in the oral group showed undesired movement (P  <  .02). Seven @entity1 (8%) in the IV group and 2 @entity1 (3%) in the oral group showed poor cooperation (P >  .05). Fifteen @entity1 (18%) in the IV  group and 9 @entity1 (12%) in the oral group had @entity148 (P >  .05). Three @entity1 (4%) in the  IV group and 3 @entity1 (4%) in the oral group experienced @entity158 (P >  .05). CONCLUSIONS: Fewer @entity1 receiving oral @entity3175 30  minutes before @entity231 surgery than @entity1 receiving IV @entity1363 immediately preceding surgery showed undesired movement during surgery. There was no statistically significant difference in the number of @entity1 showing poor cooperation or experiencing @entity158 or @entity148 between the 2 groups. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Oral XXXX versus intravenous @entity1363 for conscious sedation during @entity231 surgery performed using topical anesthesia.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3175 :: ('MESH:D003975', 'Chemical') :: ['diazepam']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'intraoperative pain']

entities_list: @entity1363 :: ('MESH:D008874', 'Chemical') :: ['midazolam']

answer: @entity3175 :: (MESH:D003975,Chemical) :: ['diazepam']


abstract: PURPOSE: To compare the @entity158 , @entity148 , undesired movement, and cooperation between @entity1 receiving oral @entity3175 or intravenous (IV) @entity1363 for conscious sedation during @entity231 surgery under topical anesthesia. SETTING: Ambulatory surgical center, Honolulu, Hawaii, USA. DESIGN: Prospective randomized controlled trial. METHODS: @entity1 having first-time @entity231 extraction with topical anesthesia were randomized to receive sedation with oral @entity3175 30  minutes before surgery or IV @entity1363 immediately preceding surgery. The outcomes of @entity158 , @entity148 , undesired movement, and poor cooperation were observed by the surgeon and recorded during surgery. RESULTS: One hundred fifty-six @entity231 surgeries were included, 83 in the IV @entity1363 group and 73 in the oral @entity3175 group. Twenty-four @entity1 (29%) in the IV group and 7 @entity1 (10%) in the oral group showed undesired movement (P  <  .02). Seven @entity1 (8%) in the IV group and 2 @entity1 (3%) in the oral group showed poor cooperation (P >  .05). Fifteen @entity1 (18%) in the IV  group and 9 @entity1 (12%) in the oral group had @entity148 (P >  .05). Three @entity1 (4%) in the  IV group and 3 @entity1 (4%) in the oral group experienced @entity158 (P >  .05). CONCLUSIONS: Fewer @entity1 receiving oral @entity3175 30  minutes before @entity231 surgery than @entity1 receiving IV @entity1363 immediately preceding surgery showed undesired movement during surgery. There was no statistically significant difference in the number of @entity1 showing poor cooperation or experiencing @entity158 or @entity148 between the 2 groups. FINANCIAL DISCLOSURE: No author has a financial or proprietary interest in any material or method mentioned.

title: Oral @entity3175 versus intravenous @entity1363 for conscious sedation during XXXX surgery performed using topical anesthesia.

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']