abstract: PURPOSE: Prolonged sedentary time (ST) is associated with cardiovascular risk factors (CV-RF) independent of physical activity (PA). Whether a high level of @entity410 ( @entity410 ) can modify the deleterious health consequences related to high ST is not known. METHODS: We performed a cross-sectional study of 12,274 @entity1 and 14,209 @entity1 (>= 20 yr) without known @entity65 . Self-reported ST measurements during a regular day were divided into three sex-specific equally sized groups ( <=4, 5 to <7, and >= 7 h  d). @entity410 was estimated (eCRF) using a previously validated nonexercise model. Using logistic regression analyses, adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated for the association of ST with CV-RF clustering and for the potential modifying effect of eCRF. RESULTS: Each hour increase in ST was associated with 5% and 4% greater likelihood of having CV-RF clustering independent of PA in @entity1 and @entity1 , respectively. Among the @entity1 with higher levels of eCRF, the adjusted OR values associated with >= 7 h  d of ST were 0.92 (0.56-1.51) for @entity1 and 1.16 (0.49-2.74) for @entity1 , compared with @entity1 and @entity1 with low ST ( <=4 h  d) and high eCRF levels. In combined analyses of eCRF, PA, and ST, compared with the reference group of @entity1 meeting the recommendations,  <=4 h  d of ST and high eCRF, the OR values were 0.63 (0.27-1.44) and 0.65 (0.14-3.07) in fit @entity1 and @entity1 with >= 7 h  d of ST, which did not meet the recommendations. @entity1 and @entity1 meeting the PA recommendations, but were unfit, had significantly increased odds of having CV-RF clustering across levels of ST. CONCLUSION: High levels of eCRF abolished the increased odds of having CV-RF clustering associated with high ST, even among those individuals who did not meet the current PA recommendations.

title: @entity410 , Sedentary Time, and XXXX .

answer: @entity65 :: (MESH:D002318,Disease) :: ['Cardiovascular Risk Factor Clustering']


abstract: OBJECTIVE: The objective of our study was to retrospectively determine the prevalence and image findings of extraarticular @entity14948 with os sustentaculum, a type of @entity14948 that does not appear in current classification systems, in @entity1 with an imaging diagnosis of foot coalition. MATERIALS AND METHODS: This study was performed using a database query of radiology reports of ankle and foot CT or MRI examinations performed from August 2001 to November 2013. Eighty-one @entity1 were identified through a keyword search of the database for " @entity14948 ," " @entity8214 ," "coalition," or "os sustentaculum." Imaging features of CT or MRI findings were evaluated. Chart review was used to identify demographic information. RESULTS: Extraarticular @entity14948 with os sustentaculum was diagnosed in 13 @entity1 (nine @entity1 , four @entity1 ), which represents a prevalence of 16.0% (13/81) in all foot coalitions and 24.1% (13/54) in all @entity14948 . Four of 13 @entity1 underwent surgical resection, and histology was obtained in three @entity1 . Nine @entity1 who had no history of @entity130 were symptomatic and all @entity1 with @entity236 at the coalition sites on MRI (n = 5) were also symptomatic. Coexisting extraarticular @entity14948 with os sustentaculum and @entity7334 were observed in 11 of 13 @entity1 . CONCLUSION: The os sustentaculum is a component of extraarticular @entity14948 and as such is usually related to the presence of symptoms. If a @entity1 with an os sustentaculum has symptoms in the medial talocalcaneal joint area, an extraarticular @entity14948 related to the os sustentaculum should be considered.

title: A Different Type of XXXX With Os Sustentaculum: The Continued Necessity of Revision of Classification.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity8214 :: ('MESH:C536943', 'Disease') :: ['tarsal coalition']

entities_list: @entity14948 :: ('MESH:C536895', 'Disease') :: ['talocalcaneal coalition', 'talocalcaneal coalitions']

entities_list: @entity7334 :: ('MESH:D057072', 'Disease') :: ['intraarticular talocalcaneal coalition']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow edema']

answer: @entity14948 :: (MESH:C536895,Disease) :: ['Talocalcaneal Coalition']


abstract: OBJECTIVE: To study the effects of Kangai injection on the enzyme activities of macrophages and morphology of spleen and thymus from @entity35 . METHODS: Twenty four male SD @entity35 were randomly divided into two groups (n = 12), normal control group and experimental group. The @entity35 in experimental group were injected with Kangai injection at the dosage of 5 ml/kg x d for 30 days peritoneally and those in control group were injected with nomal saline at the same volume. The content of supermicro protein was assayed by BCA method, the activities of lactate dehydrogenase (LDH), glutathione peroxidase( @entity35866 ), and @entity1506 ( @entity1506 ) from alveolar macrophages(AM) and peritoneal macrophages (PM) were detected biochemically. The activities of acid phosphatase (ACP), superoxide dismutase(SOD) and succinate dehydrogenase (SDH) from AM and PM were detected by ELISA. The morphology of spleen and thymus were observed by light microscopy. RESULTS: The activities of LDH, @entity35866 and @entity1506 within AM and PM from experimental group were increased significantly compared with those of control group (P < 0.05). The activities of ACP, SOD and SDH in AM and PM from experimental group were also higher than those from control group (P < 0.05). Microscopically, there was thickening of peripheral arterial lymphatic sheath, enlargement of splenic lymphoid nodules with expended germinal center in the spleen of experimental group. There was no significant difference in the mophology of thymus between the two groups. CONCLUSION: Kangai injection may improve immune function by activating macrophages.

title: [The effects of Kangai injection on enzyme activities of macrophages in XXXX ].

entities_list: @entity1506 :: ('24599(Tax:10116)', 'Gene') :: ['inducible nitric oxide synthase', 'iNOS']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: ETHNOPHARMACOLOGICAL RELEVANCE: Nepal, a mountainous country having diversified topographic and climatic conditions, gives rise to a wide range of flora and fauna. In villages ethnic @entity1 , including Magar and Majhi highly depend on medicinal plants for their primary healthcare. Due to overexploitation, encroachment in forest for arable land and destruction of natural habitat, potentially useful medicinal plants are going to be threatened in their natural environment. There is a strong need to enlist highly valuable medicinal plants and use traditional knowledge to protect, utilize and manage them in ex-situ and in-situ conservation. The present research investigates and documents traditional knowledge on medicinal plants utilization as natural medicine by two ethnic communities Magar and Majhi of Parbat district in Western Nepal. METHODS: Ethnomedicinal data was collected during 2012-2013 by the following standard ethnobotanical methods. Data about medicinal uses of herbs, shrubs and trees were collected using semi-structured questionnaire, field observation, personal interview and group discussion with 334 (130 @entity1 and 204 @entity1 ) pre-identified local informants, among which 13 male and 2 female were local healers. Statistical tool, informant consensus factors ( @entity7721 ) and fidelity level (FL) values were used to analyze the importance of ethnomedicinal plants. RESULTS: A total of 132 ethnomedicinal plant species belonging to 99 genera and 67 families have been documented. These plants are used to treat @entity66 and disorders grouped under 12 disease categories, with the highest number of species (61) being used for gastro-intestinal, @entity4801 ( @entity7721 =0.78%), followed by blood and lymphatic system ( @entity7721 =0.76%) category. The highest fidelity level (FL) values recorded in Paris polyphylla (FL=96.0%) followed by Bergenia ciliata (FL=95.0%) confirms that these plants are the best plant species with medicinal properties. CONCLUSIONS: The two ethnic communities, Magar and Majhi, in Parbat district are rich in ethnomedicinal knowledge. The high degree of consensus among the informants suggests that current use and knowledge are still strong, and thus the preservation of indigenous knowledge would show good foresight in acting before much has been lost.

title: An ethnobotanical study of medicinal plants used by ethnic XXXX in Parbat district of western Nepal.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'people', 'men']

entities_list: @entity4801 :: ('MESH:D010272', 'Disease') :: ['parasitic and hepatobiliary disorders']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['various diseases']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: UNASSIGNED: @entity3957 ( @entity3958 ) has recently been identified as an endogenous gaseous signaling molecule. In the vascular system, the formation of @entity3958 is catalyzed by @entity3959  y  -lyase (CSE). Previous studies have demonstrated the protective effects of @entity3958 on @entity63 in various types of tissue. However,, little is known about the role of @entity3958 in @entity6 -associated @entity455 . Thus, the aim of the present study was to examine the possible role of @entity3958 in high @entity413 -induced @entity455 , and to explore the underlying mechanisms. @entity1 umbilical vein endothelial cells (HUVECs) were isolated from @entity1 umbilical veins. The levels of @entity3958 following treatment with various levels of @entity413 were determined and the secretion of @entity2232 ( @entity2232 ) was measured by ELISA. The mRNA and protein expression of CSE in the HUVECs was determined by real-time RT-PCR and western blot analysis, respectively. Treatment with high @entity413 (25  mmol/l) for 48  h significantly increased the secretion of @entity2232 by HUVECs, with the concomitant suppression of @entity3958 production and CSE protein expression. The increase in exogenous @entity3958 levels through the administration of @entity8835 ( @entity8835 ) attenuated the high @entity413 -induced downregulation of CSE protein expression, and significantly inhibited the secretion of @entity2232 . These results suggest that the downregulation of CSE protein expression and the subsequent decrease in @entity3958 production play a role in high @entity413 -induced @entity455 possibly by increasing the secretion of @entity2232 by endothelial cells.

title: High @entity413 induces the release of @entity2232 through the inhibition of XXXX production in HUVECs.

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular diseases', 'vascular dysfunction']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic injury']

entities_list: @entity3959 :: ('MESH:D003540', 'Chemical') :: ['cystathionine']

entities_list: @entity8835 :: ('MESH:C025451', 'Chemical') :: ['NaHS', 'sodium hydrosulfide']

entities_list: @entity3957 :: ('MESH:D006862', 'Chemical') :: ['Hydrogen sulfide']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity3957 :: (MESH:D006862,Chemical) :: ['hydrogen sulfide']


abstract: UNASSIGNED: @entity3957 ( @entity3958 ) has recently been identified as an endogenous gaseous signaling molecule. In the vascular system, the formation of @entity3958 is catalyzed by @entity3959  y  -lyase (CSE). Previous studies have demonstrated the protective effects of @entity3958 on @entity63 in various types of tissue. However,, little is known about the role of @entity3958 in @entity6 -associated @entity455 . Thus, the aim of the present study was to examine the possible role of @entity3958 in high @entity413 -induced @entity455 , and to explore the underlying mechanisms. @entity1 umbilical vein endothelial cells (HUVECs) were isolated from @entity1 umbilical veins. The levels of @entity3958 following treatment with various levels of @entity413 were determined and the secretion of @entity2232 ( @entity2232 ) was measured by ELISA. The mRNA and protein expression of CSE in the HUVECs was determined by real-time RT-PCR and western blot analysis, respectively. Treatment with high @entity413 (25  mmol/l) for 48  h significantly increased the secretion of @entity2232 by HUVECs, with the concomitant suppression of @entity3958 production and CSE protein expression. The increase in exogenous @entity3958 levels through the administration of @entity8835 ( @entity8835 ) attenuated the high @entity413 -induced downregulation of CSE protein expression, and significantly inhibited the secretion of @entity2232 . These results suggest that the downregulation of CSE protein expression and the subsequent decrease in @entity3958 production play a role in high @entity413 -induced @entity455 possibly by increasing the secretion of @entity2232 by endothelial cells.

title: High XXXX induces the release of @entity2232 through the inhibition of @entity3957 production in HUVECs.

answer: @entity413 :: (MESH:D005947,Chemical) :: ['glucose']


abstract: UNASSIGNED: @entity3957 ( @entity3958 ) has recently been identified as an endogenous gaseous signaling molecule. In the vascular system, the formation of @entity3958 is catalyzed by @entity3959  y  -lyase (CSE). Previous studies have demonstrated the protective effects of @entity3958 on @entity63 in various types of tissue. However,, little is known about the role of @entity3958 in @entity6 -associated @entity455 . Thus, the aim of the present study was to examine the possible role of @entity3958 in high @entity413 -induced @entity455 , and to explore the underlying mechanisms. @entity1 umbilical vein endothelial cells (HUVECs) were isolated from @entity1 umbilical veins. The levels of @entity3958 following treatment with various levels of @entity413 were determined and the secretion of @entity2232 ( @entity2232 ) was measured by ELISA. The mRNA and protein expression of CSE in the HUVECs was determined by real-time RT-PCR and western blot analysis, respectively. Treatment with high @entity413 (25  mmol/l) for 48  h significantly increased the secretion of @entity2232 by HUVECs, with the concomitant suppression of @entity3958 production and CSE protein expression. The increase in exogenous @entity3958 levels through the administration of @entity8835 ( @entity8835 ) attenuated the high @entity413 -induced downregulation of CSE protein expression, and significantly inhibited the secretion of @entity2232 . These results suggest that the downregulation of CSE protein expression and the subsequent decrease in @entity3958 production play a role in high @entity413 -induced @entity455 possibly by increasing the secretion of @entity2232 by endothelial cells.

title: High @entity413 induces the release of XXXX through the inhibition of @entity3957 production in HUVECs.

answer: @entity2232 :: (1906,Gene) :: ['endothelin-1']


abstract: UNASSIGNED: Aims: Closure of @entity4616 ( @entity4616 ) is non-inferior to medical treatment for @entity1 with cryptogenic @entity64 . Results in randomised trials might be based on the different types of used occluders. We determined residual shunting with serial contrast transoesophageal echocardiography (cTEE) and evaluated rates of recurrent cerebrovascular events in a long-term follow-up. Methods and results: cTEE was repeated three and 12 months after @entity4616 closure using AMPLATZER (n=109), BioSTAR (n=68), @entity418 (n=104) or Premere (n=54) occluders. Closure was demonstrated in 91.6% and 95.9% of @entity1 after three and 12 months. Closure rates were not different among groups (p=0.58; p=0.94). The @entity4616 diameter was a risk factor for residual shunting (p=0.02), but not the prevalence of an @entity439 ( @entity439 ). During follow-up, including 1,815 @entity1 -years (PY), eight @entity1 suffered a @entity64 (0.44/100 PY) and seven @entity1 a transient ischaemic attack (0.39/100 PY). Rates of recurrent cerebrovascular events were similar among the four groups. Conclusions: Closure at three or 12 months (as measured by cTEE) and rates of recurrent cerebrovascular events were similar among occluder groups. @entity4616 diameter was a risk factor for residual shunting, but not the presence of @entity439 . The rate of recurrent cerebral ischaemic events was low.

title: Efficacy of different devices for transcatheter closure of XXXX assessed by serial transoesophageal echocardiography and rates of recurrent cerebrovascular events in a long-term follow-up.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['ASA', 'atrial septal aneurysm']

entities_list: @entity4616 :: ('MESH:D054092', 'Disease') :: ['patent foramen ovale', 'PFO']

answer: @entity4616 :: (MESH:D054092,Disease) :: ['patent foramen ovale']


abstract: PURPOSE: We evaluated the risk of @entity263 reclassification by time on active surveillance. MATERIALS AND METHODS: From 1995 to 2014 we evaluated 557 and 251 @entity1 at very low and at low risk, respectively, who were on active surveillance and compliant with prostate biopsies. Our primary study outcome was reclassification to higher risk disease by grade or extent. Freedom from reclassification was estimated using the Kaplan-Meier approach with adjustment for covariates using the Cox proportional hazards model. RESULTS: Within the first 2 years of surveillance @entity1 survival free of reclassification by grade (p = 0.20) and by any biopsy criteria (p = 0.25) was similar in @entity1 with very low and @entity258 . After 2 years @entity1 with @entity258 were 2.4 times more likely to be diagnosed with a Gleason score of greater than 6  than @entity1 with very @entity258 (p = 0.002, HR 2.4, 95% CI 1.9-3.5). Additionally, beyond 2 years on surveillance the risk of lifetime reclassification by grade and by any criteria decreased by 30% and 35% (each p <0.0001, HR 0.70, 95% CI 0.60-0.76 and HR 0.65, 95% CI 0.57-0.72, respectively) with each biopsy that showed no reclassification. CONCLUSIONS: The reclassification rate during surveillance is not equally distributed across time or risk groups. Due to misclassification at diagnosis the reclassification rate in very low and low risk groups is similar in the first 2 years but differs significantly beyond 2 years. The risk of reclassification decreases with time for each nonreclassifying biopsy beyond 2 years.

title: Conditional Probability of Reclassification in an Active Surveillance Program for XXXX .

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['low risk disease']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

answer: @entity263 :: (MESH:D011471,Disease) :: ['Prostate Cancer']


abstract: OBJECTIVE: Occupational @entity3329 are a worldwide problem. Certain occupations pose a greater risk than others. Recent statistics on global @entity5281 and diseases that might lead to @entity2319 and even worse might lead to @entity204 , are staggering. The purpose of this study was to estimate the @entity204 rates from @entity5281 in Jordan over a period of four years; to estimate occupational fatality rate that results from @entity130 and identify the most risky concurrent occupations with the type of @entity130 , the age and nationality of the victims. METHOD: A total of 88 work related @entity3329 were admitted to three hospitals in Amman through 2008-2012 and were examined by a forensic (occupational) physician at the time. They were categorized according to, age, nationality, occupation, @entity130 and were all tested for toxic substances. RESULTS: The occupation with the most @entity3329 was construction (44%); falling from a height was the commonest type of accident (44%) and @entity542 were the leading injury type (21.6%); 9.1% of the @entity204 were positive for @entity167 . Moreover, 22.7% of @entity204 were between ages of 25-29. Consequently, the mean occupational fatality rate was 2 per 100.000 workers during 2008-2012. CONCLUSION: Constructions and other types of occupations are more extensive problems than what is usually anticipated, especially when safety precautions are not effective or implemented. They may cause @entity130 and @entity204 , which will have a socioeconomic burden on families, society, governments and industries. Not to mention the grief that is associated with the @entity204 of a worker at his work site to all concerned parties.

title: Occupational XXXX in Jordan.

entities_list: @entity3329 :: ('MESH:D008206', 'Disease') :: ['fatalities']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head injuries']

entities_list: @entity2319 :: ('MESH:D003638', 'Disease') :: ['temporary or permanent disability']

entities_list: @entity5281 :: ('MESH:D060051', 'Disease') :: ['occupational injuries']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['death', 'deaths']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries', 'type of injury', 'accidental injuries']

answer: @entity3329 :: (MESH:D008206,Disease) :: ['fatalities']


abstract: Behaviour of the filtration of red blood cells (rbc) passed through a filter paper was investigated. The rbc were incubated in fractions of blood plasma with different molecular mass (MM). By means of an Amicon membrane XM-50 the separation of plasma from healthy and @entity1381 @entity1 ( @entity1 ) was performed into two parts of different molecular sizes one of these was the concentrate (MM more than 50 000 = K) and the other was the ultrafiltrate (MM below 50 000 = UF). By a second step the UF was divided (Amicon membrane UM-50 into an UF1 (MM below 500) and into an UF2 (MM 500 to 50 000). In addition a hemofiltrate (MM below 5 000) was used for the incubation too. This hemofiltrate was made form pooled plasma of healthy and @entity1381 @entity1 , respectively. Rbc was incubated in both different fractions of plasma and hemofiltrate at a temperature of 37 degrees C and for a duration of 60 min. The pH-level and the osmolality were physiological. Under the influence of @entity1381 UF the flexibility of rbc was clearly decreased. The UF1 had the most effect of the decrease of flexibility. Therefore the small substances which are easy dialysable play also an important role in the damage of rbc in the @entity5507 .

title: [Effect of XXXX plasma fractions of different molecular sizes on the filterability of red blood cells].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'children']

answer: @entity1381 :: (MESH:D006463,Disease) :: ['uremic']


abstract: BACKGROUND AND PURPOSE: Prophylactic anticoagulation for @entity1150 prevention after @entity1779 ( @entity1779 ) is safe. Current guidelines recommend prophylactic anticoagulation after cessation of @entity1410 growth. We aimed to evaluate nationwide trends in @entity1150 prophylaxis after @entity1779 . METHODS: In an analysis of the Premier database, we identified adult @entity1 with @entity1779 (International Classification of Diseases Ninth edition code 431) from 2006 to 2010 who survived to day 2 of hospitalization. We excluded those with @entity130 or who underwent craniotomy or angiography. We abstracted type of anticoagulant used and date of first administration. We used univariate statistics and multivariable logistic regression to assess factors associated with prophylactic anticoagulation after @entity1779 . RESULTS: Among 32 690 (mean age, 69.7 years; 50.1% @entity1 ) @entity1 with spontaneous @entity1779 , 5395 (16.5%) @entity1 received any prophylactic anticoagulation during the hospital stay. Among these @entity1 , 2416 (44.8%) received prophylactic anticoagulation by day 2. The most commonly used agents were heparin (71.1%), enoxaparin (27.5%), and dalteparin (1.4%). The proportion of @entity1 receiving prophylactic anticoagulation increased slightly during the study period from 14.3% to 18.0% (P<0.01 for trend). Use of prophylactic anticoagulation varied by geographic region (P<0.001) in the United States: Northeast (23.2%), South (19.0%), Midwest (10.8%), and West (9.8%). In multivariable analysis, geographic region remained an independent predictor of prophylactic anticoagulation. CONCLUSIONS: Less than 20% of @entity1 with @entity1779 receive anticoagulation for @entity1150 in the United States. When used, the time to initiation is <2 days in less than half of the @entity1 . Further study should focus on understanding variations in practice and emphasize guideline-driven care.

title: Is Prophylactic Anticoagulation for Deep Venous Thrombosis Common Practice After XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep venous thrombosis']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['ICH', 'intracerebral hemorrhage']

answer: @entity1779 :: (MESH:D002543,Disease) :: ['Intracerebral Hemorrhage']


abstract: UNASSIGNED: Aims: To investigate the relationship between @entity716 and @entity73 in @entity195 ( @entity195 ). Methods: A total of 108 subjects affected by @entity195 were subdivided into subjects without delusions ( @entity11702 ), subjects with @entity10963 ( @entity10963 ), subjects with @entity4750 ( @entity4750 ), subjects with both @entity4750 and @entity10963 ( @entity4750 + @entity10963 ), subjects with @entity1833 ( @entity1833 ), and subjects without @entity1833 (N-HALL). Results: @entity10963 and @entity11702 subjects performed similarly on neuropsychological tests, while @entity4750 @entity1 performed significantly worse than @entity10963 and @entity11702 @entity1 . @entity1833 @entity1 performed worse than N-HALL @entity1 on memory, visuospatial, and executive functions. As for behavioral features, @entity4750 and @entity1833 subjects reported higher scores on the abnormal motor behavior subscale of the neuropsychiatric inventory (NPI); @entity10963 subjects reported higher scores on the disinhibition subscale of the NPI. The severity of @entity10963 was predicted by the severity of disinhibition (B = 0.514; p = 0.016) but not by neuropsychological performances. The severity of @entity4750 was predicted by age (B = 0.099; p = 0.048) and MMSE (B = -0.233; p = 0.001). The severity of @entity1833 was predicted by age (B = 0.052; p = 0.037) and scores on an immediate visual memory task (B = -0.135; p = 0.007). Conclusions: The occurrence of @entity10963 may require the relative sparing of cognitive functions and be @entity75 , while @entity4750 is associated with the overall level of @entity73 . Finally, @entity1833 are associated with the impairment of visuospatial abilities.    2015 S. Karger AG, Basel.

title: Cognitive and Behavioral Determinants of Psychotic Symptoms in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4750 :: ('MESH:D012563', 'Disease') :: ['delusional misidentifications', 'DM']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['favored by frontal lobe dysfunction']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairment']

entities_list: @entity1833 :: ('MESH:D006212', 'Disease') :: ['visual hallucinations', 'v-HALL']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychotic symptoms']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

entities_list: @entity10963 :: ('MESH:D010259', 'Disease') :: ['PD', 'paranoid delusions']

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer's Disease']


abstract: @entity785 ( @entity785 ) is a complex disease involving @entity74 . An association of the @entity22367 polymorphism with @entity785 was reported in Caucasian populations of Europe and North America, as well as in Japanese populations. The present study aimed to examine whether the @entity785 -associated SNP @entity44305 of @entity22367 gene confer susceptibility to @entity785 and clinical features of @entity785 in a Han Chinese population. A Han Chinese cohort consisting of 424 @entity785 @entity1 and 502 healthy controls were examined in the study. TaqMan assays were carried out to examine the SNP. Exact p-values were obtained (Fisher  s test) from 2x2 tables of allele counts and disease status. @entity785 @entity1 of Han Chinese showed increased homozygous TT genotype of the @entity44305 (p = 0.027, odds ratio (OR) = 1.4, CI =1.03-1.93), which was significantly associated with @entity3794 of @entity785 and ATA-positive @entity785 of Han Chinese. The lcSSc and ACA-positive @entity785 of Han Chinese appeared also in association with the increased T allele frequency. However, the Chinese dcSSc did not show any association with the @entity44305 . The results were consistent with previous reports in other ethnic populations in supporting the notion that polymorphisms of @entity22367 may play an important role in susceptibility to @entity785 .

title: ASSOCIATION OF THE @entity22367 SNP XXXX WITH SYSTEMIC SCLEROSIS IN HAN CHINESE.

entities_list: @entity3794 :: ('MESH:D011658', 'Disease') :: ['pulmonary fibrosis']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['multiple genetic factors']

entities_list: @entity785 :: ('MESH:D012595', 'Disease') :: ['Systemic sclerosis', 'SSc']

answer: @entity44305 :: (rs2004640,SNP) :: ['rs2004640']


abstract: @entity785 ( @entity785 ) is a complex disease involving @entity74 . An association of the @entity22367 polymorphism with @entity785 was reported in Caucasian populations of Europe and North America, as well as in Japanese populations. The present study aimed to examine whether the @entity785 -associated SNP @entity44305 of @entity22367 gene confer susceptibility to @entity785 and clinical features of @entity785 in a Han Chinese population. A Han Chinese cohort consisting of 424 @entity785 @entity1 and 502 healthy controls were examined in the study. TaqMan assays were carried out to examine the SNP. Exact p-values were obtained (Fisher  s test) from 2x2 tables of allele counts and disease status. @entity785 @entity1 of Han Chinese showed increased homozygous TT genotype of the @entity44305 (p = 0.027, odds ratio (OR) = 1.4, CI =1.03-1.93), which was significantly associated with @entity3794 of @entity785 and ATA-positive @entity785 of Han Chinese. The lcSSc and ACA-positive @entity785 of Han Chinese appeared also in association with the increased T allele frequency. However, the Chinese dcSSc did not show any association with the @entity44305 . The results were consistent with previous reports in other ethnic populations in supporting the notion that polymorphisms of @entity22367 may play an important role in susceptibility to @entity785 .

title: ASSOCIATION OF THE XXXX SNP @entity44305 WITH SYSTEMIC SCLEROSIS IN HAN CHINESE.

answer: @entity22367 :: (3663,Gene) :: ['IRF5']


abstract: UNASSIGNED: @entity1 are living longer but morbidity has also increased; threatening to create a serious global burden. Our approach is to monitor gait for early warning signs of morbidity. Here we present highlights from a series of experiments into gait as a potential biomarker for @entity191 ( @entity191 ), ageing and fall risk. Using body-worn accelerometers, we developed several novel camera-less methods to analyze head and pelvis movements while walking. Signal processing algorithms were developed to extract gait parameters that represented the principal components of vigor, head jerk, lateral harmonic stability, and oscillation range. The new gait parameters were compared to accidental falls, mental state and co-morbidities. We observed: 1) @entity1 with @entity191 had significantly larger and uncontrolled anterioposterior (AP) oscillations of the head; 2) Older @entity1 walked with more lateral head jerk; and, 3) the combination of vigorous and harmonically stable gait was demonstrated by non-fallers. Our findings agree with research from other groups; changes in @entity1 gait reflect changes to well-being. We observed; different aspects of gait reflected different functional outcomes. The new gait parameters therefore may be complementary to existing methods and may have potential as biomarkers for specific disorders. However, further research is required to validate our observations, and establish clinical utility.

title: Gait as a biomarker? Accelerometers reveal that reduced movement quality while walking is associated with XXXX , ageing and fall risk.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'people', 'Humans', 'People']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", 'PD']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson's disease']


abstract: UNASSIGNED: Bone architecture as size and shape is important for bone strength and risk of @entity174 . Most @entity604 is cortical and occurs by trabecularisation of the inner part of the cortex. We therefore wanted to identify determinants of the bone architecture, especially the area and porosity of the transitional zone, an inner cortical region with a large surface/matrix volume available for intracortical @entity5707 . In 211 postmenopausal @entity1 aged 54-94 years with @entity174 and 232 controls from the Troms   Study, Norway, we quantified femoral subtrochanteric architecture in CT images using StrAx1.0 software, and serum levels of bone turnover markers (BTM). Multivariable linear and logistic regression analyses were used to quantify associations of age, weight, height, and bone size with bone architecture and BTM, and odds ratio (OR) for @entity174 . Increasing age, height and larger total cross-sectional area (TCSA) were associated with larger transitional zone @entity9472 and transitional zone @entity9472 /TCSA (standardized coefficients (STB)   =   0.11-0.80, p  <= 0.05). Increasing weight was associated with larger TCSA, but smaller transitional zone @entity9472 /TCSA and thicker cortices (STB   =   0.15-0.22, p   <   0.01). Increasing height and TCSA were associated with higher porosity of the transitional zone (STB   =   0.12-0.46, p   <   0.05). Increasing BTM were associated with larger TCSA, larger transitional zone @entity9472 /TCSA and higher porosity of each of the cortical compartments (p   <   0.01). @entity174 cases exhibited larger transitional zone @entity9472 and higher porosity than controls (p   <   0.001). Per SD increasing @entity9472 and porosity of the transitional zone, OR for @entity174 was 1.71 (95% confidence interval 1.37-2.14) and 1.51 (1.23-1.85). Cortical bone architecture is determined mainly by bone size as built during growth and is modified by lifestyle factors throughout life through bone turnover. @entity174 cases exhibited larger transitional zone area and porosity, highlighting the importance of cortical bone architecture for @entity174 propensity. This article is protected by copyright. All rights reserved.

title: Determinants of Transitional Zone Area and Porosity of the Proximal Femur Quantified In Vivo in Postmenopausal XXXX .

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['Fracture', 'non-vertebral fractures', 'fracture']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity5707 :: ('MESH:D020257', 'Disease') :: ['remodeling']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: BACKGROUND: Limited data describe the prognosis after stereotactic ablative radiotherapy for lung metastases arising from @entity14 . Thus, we evaluated treatment outcomes of stereotactic ablative radiotherapy for those @entity1 . METHODS: The study involved @entity1 received stereotactic ablative radiotherapy for one to three lung metastases arising from @entity14 at a single institution. A total dose of 40-60  Gy (median, 48  Gy) in three or four fractions was prescribed. RESULTS: A total of 79 metastatic lung lesions from 50 @entity1 who underwent curative resection for their primary @entity14 or salvage treatment at a recurrent site were included. The one- and three-year local control rates were 88.7  % and 70.6  %, respectively. The three-year overall survival and progression-free survival rates were 64.0  % and 24.0  %, respectively. @entity1 with @entity5 volume  <=1.5  mL had a significantly better overall survival rate than those with @entity5 volume >1.5  mL (68.0  % vs. 60.0  % at three-year, p   =   0.02). Local control was associated with a trend towards better survival (p   =   0.06). No @entity358 greater than grade 2 were observed. CONCLUSION: Stereotactic ablative radiotherapy is a competitive treatment modality for the management of lung metastases arising from @entity14 .

title: Clinical efficacy of stereotactic ablative radiotherapy for lung metastases arising from XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary complications']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: OBJECTIVE: To compare the perioperative data, pathological results and functional outcomes of transvesical single- site laparoscopic radical prostatectomy (TVSSLRP) with those of nerve-sparing extraperitoneal laparoscopic radical prostatectomy (nsELRP) in the treatment of @entity263 (PCa). METHODS: Fifty @entity1 with low-risk organ-confined PCa were randomly assigned to two groups of equal number to receive TVSSLRP and nsELRP, respectively. Comparisons were made between the two groups of @entity1 in such demographic and baseline data as age, comorbidity, body mass index (BMI), serum @entity1486 , prostate volume, bioptic Gleason score, clinical stage, IIEF-5 score, nocturnal penile tumescence (NPT), penile brachial index (PBI), and penile arterial blood flow velocity as well as in such surgery-related parameters as operation duration, @entity190 , blood transfusion, @entity3816 , positive surgical margin, catheterization time, hospital stay, and postoperative Gleason score, pathologic stage, urinal pad use, @entity1486 level, IIEF-5 score, NPT, PBI and PABFV. RESULTS: All the operations were successfully performed. There were no statistically significant differences between the two groups either in the demographic and baseline data or in intraoperative @entity190 , blood transfusion rate, complications, and positive surgical margin. No @entity3816 and positive surgical margins were found in either group. Compared with nsELRP, TVSSLRP achieved a significantly shorter operation duration ([151.46    40.68] min vs [105.92    26.21] min, P <0.05), catheterization time ([13.01    1.64] d vs [11.24    1.17] d, P <0.05), and hospital stay ([15.76    4.65] d vs [12.92    4.29] d, P <0.05). On the first day and at 1, 3 and 6 months after catheter removal, the urinary continence rates in the TVSSLRP and nsELRP groups were 84% vs 52% (P <0.05), 100% vs 84%, 100% vs 96%, and 100% vs 96%, respectively; and at 3, 6 and 12 months after surgery, the erectile potency rates were 48% vs 28% (P <0.05), 64% vs 52%, and 76% vs 68%, respectively, with an IIEF-5 score >=  18, all evidently higher in the TVSSLRP than in the nsELRP group. The penile brachial index and arterial blood flow velocity of the two groups of @entity1 exhibited no significant differences before and after surgery, nor did postoperative complications (grade II) between the TVSSLRP and nsELRP groups (32% vs 40%, P >0.05). The Gleason score and pathologic stage were increased after surgery, but with remarkable differences between the two groups (P >0.05). No biochemical recurrence was found in either group during a 12-month follow-up. CONCLUSION: With the advantages of safety and rapid postoperative recovery, both TVSSLRP and nsELRP are feasible for the treatment of low-risk organ-confined PCa, but the former may achieve an earlier recovery of urinary continence and erectile function than the latter.

title: [Functional outcomes of transvesical single-site versus extraperitoneal laparoscopic radical prostatectomy for XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['low-risk prostate cancer']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen (PSA)', 'PSA']

entities_list: @entity3816 :: ('MESH:D007431', 'Disease') :: ['intraoperative complications']

answer: @entity263 :: (MESH:D011471,Disease) :: ['low-risk prostate cancer']


abstract: INTRODUCTION: Kinesio-Taping(  ) ( @entity3529 -Tape) is used in sports traumatology with the aim of reducing @entity158 and improving blood and lymph circulation. The main objective of the present study was to assess the efficacy of K-Tape on early @entity282 after anterior cruciate ligament (ACL) reconstruction. The study hypothesis was that K-Tape significantly decreases @entity158 . METHOD: A prospective non-randomized comparative study was conducted in 2013-2014 and included all @entity1 who underwent primary ACL reconstruction by hamstring graft. @entity1337 was standardized. Two groups, "K-Tape" and "controls", were formed according to the days on which the study physiotherapist was present. The K-Tape compression/decompression assembly was applied immediately postoperatively and maintained for 3days. @entity1 filled out online questionnaires. The main assessment criterion was mean @entity282 (D0-D3) on a 0-to-10 scale. Secondary criteria were @entity1337 intake on the three WHO levels, awakening during the night of D0 due to @entity158 , signs of postoperative discomfort, and @entity1 satisfaction. RESULTS: Sixty @entity1 (30 per group) were included, 57 of whom could be assessed: 28 K-Tape, 29 controls; 44 male, 13 female; mean age, 30.9  8.9 years. At inclusion, the two groups were comparable. There was no significant difference in mean (D0-D3) knee @entity158 intensity: 3.8  2.2 for K-Tape, and 3.9  2 for controls (P=0.93). Analysis of variance (ANOVA) found no significant intergroup difference in evolution of @entity158 (P=0.34). There were no other significant differences on the other assessment criteria. CONCLUSION: K-Tape showed no efficacy on early @entity282 following ACL reconstruction. LEVEL OF EVIDENCE: III; prospective non-randomized comparative study.

title: Inefficacy of Kinesio-Taping(  ) on early XXXX after ACL reconstruction: Prospective comparative study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1337 :: ('MESH:D000699', 'Disease') :: ['analgesia', 'Analgesia']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

answer: @entity282 :: (MESH:D010149,Disease) :: ['postoperative pain']


abstract: UNASSIGNED: The flagellate @entity3177 , which causes the @entity25 when infecting a @entity1 host, goes through an intricate life cycle. It has a rather complex propulsion mechanism and swims in diverse microenvironments. These continuously exert selective pressure, to which the trypanosome adjusts with its architecture and behavior. As a result, the trypanosome assumes a diversity of complex morphotypes during its life cycle. However, although cell biology has detailed form and function of most of them, experimental data on the dynamic behavior and development of most morphotypes is lacking. Here we show that simulation science can predict intermediate cell designs by conducting specific and controlled modifications of an accurate, nature-inspired cell model, which we developed using information from live cell analyses. The cell models account for several important characteristics of the real trypanosomal morphotypes, such as the geometry and elastic properties of the cell body, and their swimming mechanism using an eukaryotic flagellum. We introduce an elastic network model for the cell body, including bending @entity2003 and simulate swimming in a fluid environment, using the mesoscale simulation technique called multi-particle collision dynamics. The in silico trypanosome of the bloodstream form displays the characteristic in vivo rotational and translational motility pattern that is crucial for survival and virulence in the vertebrate host. Moreover, our model accurately simulates the trypanosome's tumbling and backward motion. We show that the distinctive course of the attached flagellum around the cell body is one important aspect to produce the observed swimming behavior in a viscous fluid, and also required to reach the maximal swimming velocity. Changing details of the flagellar attachment generates less efficient swimmers. We also simulate different morphotypes that occur during the parasite's development in the tsetse @entity238 , and predict a flagellar course we have not been able to measure in experiments so far.

title: Simulating the Complex Cell Design of XXXX and Its Motility.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity25 :: ('MESH:D012893', 'Disease') :: ['sleeping sickness']

entities_list: @entity3177 :: ('5691', 'Species') :: ['Trypanosoma brucei']

answer: @entity3177 :: (5691,Species) :: ['Trypanosoma brucei']


abstract: OBJECTIVES: To examine the risk of any @entity174 in @entity1 with both @entity1723 ( @entity1723 ) and @entity1593 ( @entity1593 ) vs @entity1 with @entity1723 only. STUDY DESIGN: We performed a population-based cohort study. We defined @entity1723 as individuals aged  <=30  years who had a diagnosis of @entity6 recorded in the Swedish National @entity1 Register between 1964 and 2009. Individuals with @entity1593 were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both @entity1723 and @entity1593 and were matched for sex, age, and calendar period with 4598 reference individuals with @entity1723 only. We then used a stratified Cox regression analysis, where @entity1593 was modeled as a time-dependent covariate, to estimate the risk of any @entity174 and @entity3604 ( @entity572 , distal forearm, thoracic and lumbar spine, and proximal humerus) in @entity1 with both @entity1723 and @entity1593 compared with that in @entity1 with @entity1723 only. RESULTS: During follow-up, 12 @entity1 with @entity1723 and @entity1593 had a @entity174 (1 @entity3604 ). @entity1593 did not influence the risk of any @entity174 (adjusted hazard ratio  =  0.77; 95% CI  =  0.42-1.41) or @entity3604 (adjusted hazard ratio  =  0.46; 95% CI  =  0.06-3.51) in @entity1 with @entity1723 . Stratification for time since @entity1593 diagnosis did not affect risk estimates. CONCLUSION: Having a diagnosis of @entity1593 does not seem to influence @entity174 risk in young @entity1 with @entity1723 . Follow-up in this study was, however, too short to ascertain @entity3604 which traditionally occur in old age.

title: XXXX Does Not Influence Fracture Risk in Young @entity1 with  Type 1 @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity3604 :: ('MESH:D058866', 'Disease') :: ['osteoporotic fracture', 'osteoporotic fractures']

entities_list: @entity1593 :: ('MESH:D002446', 'Disease') :: ['celiac disease', 'CD']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'fracture']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['T1D', 'type 1 diabetes']

answer: @entity1593 :: (MESH:D002446,Disease) :: ['Celiac Disease']


abstract: OBJECTIVES: To examine the risk of any @entity174 in @entity1 with both @entity1723 ( @entity1723 ) and @entity1593 ( @entity1593 ) vs @entity1 with @entity1723 only. STUDY DESIGN: We performed a population-based cohort study. We defined @entity1723 as individuals aged  <=30  years who had a diagnosis of @entity6 recorded in the Swedish National @entity1 Register between 1964 and 2009. Individuals with @entity1593 were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both @entity1723 and @entity1593 and were matched for sex, age, and calendar period with 4598 reference individuals with @entity1723 only. We then used a stratified Cox regression analysis, where @entity1593 was modeled as a time-dependent covariate, to estimate the risk of any @entity174 and @entity3604 ( @entity572 , distal forearm, thoracic and lumbar spine, and proximal humerus) in @entity1 with both @entity1723 and @entity1593 compared with that in @entity1 with @entity1723 only. RESULTS: During follow-up, 12 @entity1 with @entity1723 and @entity1593 had a @entity174 (1 @entity3604 ). @entity1593 did not influence the risk of any @entity174 (adjusted hazard ratio  =  0.77; 95% CI  =  0.42-1.41) or @entity3604 (adjusted hazard ratio  =  0.46; 95% CI  =  0.06-3.51) in @entity1 with @entity1723 . Stratification for time since @entity1593 diagnosis did not affect risk estimates. CONCLUSION: Having a diagnosis of @entity1593 does not seem to influence @entity174 risk in young @entity1 with @entity1723 . Follow-up in this study was, however, too short to ascertain @entity3604 which traditionally occur in old age.

title: @entity1593 Does Not Influence Fracture Risk in Young @entity1 with  Type 1 XXXX .

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: OBJECTIVES: To examine the risk of any @entity174 in @entity1 with both @entity1723 ( @entity1723 ) and @entity1593 ( @entity1593 ) vs @entity1 with @entity1723 only. STUDY DESIGN: We performed a population-based cohort study. We defined @entity1723 as individuals aged  <=30  years who had a diagnosis of @entity6 recorded in the Swedish National @entity1 Register between 1964 and 2009. Individuals with @entity1593 were identified through biopsy report data between 1969 and 2008 from any of Sweden's 28 pathology departments. Some 958 individuals had both @entity1723 and @entity1593 and were matched for sex, age, and calendar period with 4598 reference individuals with @entity1723 only. We then used a stratified Cox regression analysis, where @entity1593 was modeled as a time-dependent covariate, to estimate the risk of any @entity174 and @entity3604 ( @entity572 , distal forearm, thoracic and lumbar spine, and proximal humerus) in @entity1 with both @entity1723 and @entity1593 compared with that in @entity1 with @entity1723 only. RESULTS: During follow-up, 12 @entity1 with @entity1723 and @entity1593 had a @entity174 (1 @entity3604 ). @entity1593 did not influence the risk of any @entity174 (adjusted hazard ratio  =  0.77; 95% CI  =  0.42-1.41) or @entity3604 (adjusted hazard ratio  =  0.46; 95% CI  =  0.06-3.51) in @entity1 with @entity1723 . Stratification for time since @entity1593 diagnosis did not affect risk estimates. CONCLUSION: Having a diagnosis of @entity1593 does not seem to influence @entity174 risk in young @entity1 with @entity1723 . Follow-up in this study was, however, too short to ascertain @entity3604 which traditionally occur in old age.

title: @entity1593 Does Not Influence Fracture Risk in Young XXXX with  Type 1 @entity6 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: @entity661 is characterized by transient @entity296 that  mimics a @entity583 in the absence of obstructive @entity453 . The onset is frequently triggered by an acute illness or intense physical or emotional stress. CASE REPORT: We describe the case of a 47-year-old @entity1 who was brought to the emergency department with acute onset @entity1353 while scuba diving. She was found to have @entity3126 radiographically. Her troponins were noted to be positive. Initial echocardiogram showed @entity5702 with @entity2915 of apex. She was treated with noninvasive ventilation and intravenous diuretic therapy and her symptoms significantly improved. She subsequently underwent cardiac catheterization which revealed nonobstructive @entity453 . An exercise stress echocardiogram was performed 2  days later that revealed resolution of the wall motion abnormality and no @entity63 at high levels of exercise. A diagnosis of reverse stress (Takotsubo) @entity296 was made based on Mayo Clinic Diagnostic criteria.    WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: This case brings to light the risk of @entity661 in divers. The diagnosis should be considered in @entity1 presenting with @entity3126 during diving.

title: XXXX Caused by Diving: Case Report and  Review  of  the Literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'myocardial dysfunction']

entities_list: @entity3126 :: ('MESH:D011654', 'Disease') :: ['acute pulmonary edema']

entities_list: @entity1353 :: ('MESH:D004417', 'Disease') :: ['shortness of breath']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity2915 :: ('MESH:D006948', 'Disease') :: ['hyperkinesis']

entities_list: @entity661 :: ('MESH:D054549', 'Disease') :: ['stress cardiomyopathy', 'Stress cardiomyopathy']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity5702 :: ('MESH:D018295', 'Disease') :: ['basal hypokinesis']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity661 :: (MESH:D054549,Disease) :: ['Stress Cardiomyopathy']


abstract: BACKGROUND: Inflammatory markers have been studied in @entity31 ( @entity31 ) for diagnosis, disease activity, and prediction of relapse. Blood neutrophil-to-lymphocyte (N/L) ratio has been used to determine outcomes of some @entity5 and @entity453 . Blood N/L ratio is a simple sign of clinical @entity32 . In this study, we examined N/L ratio in recurrent @entity1 suffering from @entity31 . METHODS: The aim of the present study was to analyze N/L ratios in serum samples of @entity31 @entity1 in remission and active phases. @entity1 ' age, extend of the disease, disease duration, disease activity, drug, and other medical history were all noted for @entity1 . @entity1851 , erythrocyte sedimentation rate, and complete blood count were determined for @entity1 . RESULTS: Forty-nine @entity31 @entity1 were admitted into the present study. The blood N/L ratios were significantly increased in active phase compared with inactive @entity31 @entity1 (p  <  0.05). The cut-off value for N/L ratio for the detection of active @entity31 @entity1 was calculated as >=   2.3 using receiver operating characteristic analysis [sensitivity: 61.2  %, specificity: 66.7  %, AUC: 0.650 (0.540-0.760), p  =  0.01]. CONCLUSIONS: Present study shows that in @entity1 with @entity31 , the blood N/L ratio is associated with active disease. N/L ratio may be used as an activity parameter in @entity31 .

title: Does neutrophil-to-lymphocyte ratio predict active XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity31 :: (MESH:D003093,Disease) :: ['ulcerative colitis']


abstract: BACKGROUND: Comprehensive and long-term @entity1 education programs designed to improve self-management can help @entity1 better manage their medical condition. Using disease management programs (DMPs) that were created for each of the risk factor according to clinical practice guidelines, we evaluate their influence on the prevention of @entity64 recurrence. METHODS: This is a randomized study conducted with @entity385 @entity1 within 1  year from their onset. Subjects in the intervention group received a 6-month DMPs that included self-management education provided by a nurse along with support in collaboration with the primary care physician. Those in the usual care group received ordinary outpatient care. The  primary end points are @entity64 recurrence and @entity64 death. @entity1 were enrolled for 2  years with plans for a 2-year follow-up after the 6-month education period (total of 30  months). RESULTS: A total of 321 eligible subjects (average age, 67.3  years; females, 96 [29.9%]), including 21 subjects (6.5%) with transient @entity63 attack, were enrolled in this study. Regarding risk factors for @entity64 , 260 subjects (81.0%) had @entity101 , 249 subjects (77.6%) had @entity2299 , 102 subjects (31.8%) had @entity6 , 47 subjects (14.6%) had @entity955 , and 98 subjects (30.5%) had @entity740 . There were no significant differences between the 2 groups with respect to subject characteristics. CONCLUSIONS: This article describes the rationale, design, and baseline features of a randomized controlled trial that aimed to assess the effects of DMPs for the secondary prevention of @entity64 . Subject follow-up is in progress and will end in  2015.

title: Baseline Feature of a Randomized Trial Assessing the Effects of Disease Management Programs for the Prevention of Recurrent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity385 :: (MESH:D002544,Disease) :: ['Ischemic Stroke']


abstract: UNASSIGNED: This study aimed to evaluate the prevalence and the relationship of @entity387 ( @entity387 ) and laryngeal motility alterations in @entity1 with @entity302 after vagus nerve stimulator (VNS) implantation. Twenty-three consecutive @entity1 with medically @entity302 underwent out-of-center sleep testing before and after VNS implantation. Eighteen eligible subjects underwent endoscopic laryngeal examination post-VNS implantation. Statistical analysis was carried out to assess an association between laryngeal motility alterations and the onset/worsening of @entity387 . After VNS implantation, 11 @entity1 showed a new-onset mild/moderate SBD. Half of the @entity1 already affected by @entity27 ( @entity27 ) showed worsening of SBD. All of the @entity1 with a new-onset @entity27 had a laryngeal pattern with left vocal cord adduction (LVCA) during VNS stimulation. The association between VNS-induced LVCA and SBD was statistically significant. This study suggests an association between VNS and SBD, hinting to a pivotal role of laryngeal motility alterations. The relationship between SBD and VNS-induced LVCA supports the need to routinely investigate sleep respiratory and laryngeal motility patterns before and after VNS implantation.

title: Laryngeal motility alteration: A missing link between @entity387 and vagus nerve stimulation for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity27 :: ('MESH:D020181', 'Disease') :: ['obstructive sleep apnea', 'OSA']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['refractory epilepsy', 'drug-resistant epilepsy']

entities_list: @entity387 :: ('MESH:D012891', 'Disease') :: ['SBDs', 'sleep breathing disorders']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: UNASSIGNED: This study aimed to evaluate the prevalence and the relationship of @entity387 ( @entity387 ) and laryngeal motility alterations in @entity1 with @entity302 after vagus nerve stimulator (VNS) implantation. Twenty-three consecutive @entity1 with medically @entity302 underwent out-of-center sleep testing before and after VNS implantation. Eighteen eligible subjects underwent endoscopic laryngeal examination post-VNS implantation. Statistical analysis was carried out to assess an association between laryngeal motility alterations and the onset/worsening of @entity387 . After VNS implantation, 11 @entity1 showed a new-onset mild/moderate SBD. Half of the @entity1 already affected by @entity27 ( @entity27 ) showed worsening of SBD. All of the @entity1 with a new-onset @entity27 had a laryngeal pattern with left vocal cord adduction (LVCA) during VNS stimulation. The association between VNS-induced LVCA and SBD was statistically significant. This study suggests an association between VNS and SBD, hinting to a pivotal role of laryngeal motility alterations. The relationship between SBD and VNS-induced LVCA supports the need to routinely investigate sleep respiratory and laryngeal motility patterns before and after VNS implantation.

title: Laryngeal motility alteration: A missing link between XXXX and vagus nerve stimulation for @entity302 .

answer: @entity387 :: (MESH:D012891,Disease) :: ['sleep apnea']


abstract: Between August 1973 and May 1979, 18 @entity1 suffering from severe @entity447 A underwent synovectomy for recurrent haemarthroses, resistant to medical management. A total of 23 joints (11 knees and 12 elbows) were subjected to operation, five @entity1 undergoing two synovectomies on different joints. Post-operative follow-up period ranged from 12 to 58 months for @entity14228 and from 29 to 76 months for knee synovectomy. All @entity1 experienced fewer haemarthroses, the average number of @entity548 episodes per joint over a 12 month period being reduced from 19 to 3 for knee joints, and from 24 to 3 for @entity2720 . This improvement was apparent in the immediate post-operative year and maintained thereafter. Over the same follow-up period nine of the 11 knee joints were found to have lost an average 42 degrees mobility. Following @entity14228 five out of 12 @entity1 lost an average of 28 degrees mobility; six @entity1 gained an average 11 degrees mobility. The post-operative complication rate was high for knee synovectomy, 54% suffering @entity548 despite haemostatic factor @entity797 levels. For @entity14228 the rate was much lower, 75% of operations being uncomplicated. The average in- @entity1 time for knee operation was 75 d, and for the elbow 19 d. We conclude that synovectomy of the knee joint is to be avoided when other means of reducing @entity548 episodes are available, whereas @entity14228 retains a useful role in the treatment of recurrent haemarthroses which do not respond to clotting factor prophylaxis.

title: The role of synovectomy in the management of recurrent haemarthroses in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'haemorrhage']

entities_list: @entity447 :: ('MESH:D006467', 'Disease') :: ['haemophilia']

entities_list: @entity14228 :: ('MESH:C535618', 'Disease') :: ['elbow synovectomy']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['elbow joints']

answer: @entity447 :: (MESH:D006467,Disease) :: ['haemophilia']


abstract: UNASSIGNED: Pseudokinases are classified by the lack of one or several of the highly conserved motifs involved in @entity4334 (nt) binding or catalytic activity of protein kinases (PKs). Pseudokinases represent    10% of the @entity1 kinome and they are found in all evolutionary classes of kinases. It has become evident that pseudokinases, which were initially considered somewhat peculiar dead kinases, are important components in several signalling cascades. Furthermore, several pseudokinases have been linked to @entity1 diseases, particularly @entity5 , which is raising interest for therapeutic approaches towards these proteins. The @entity855 -binding pocket is a well-established drug target and elucidation of the mechanism and properties of nt binding in pseudokinases is of significant interest and importance. Recent studies have demonstrated that members of the pseudokinase family are very diverse in structure as well as in their ability and mechanism to bind nts or perform @entity11064 transfer reactions. This diversity also precludes prediction of pseudokinase function, or the importance of nt binding for said function, based on primary sequence alone. Currently available data indicate that    40% of pseudokinases are able to bind nts, whereas only few are able to catalyse occasional @entity11064 transfer. Pseudokinases employ diverse mechanisms to bind nts, which usually occurs at low, but physiological, affinity. @entity855 binding serves often a structural role but in most cases the functional roles are not precisely known. In the present review, we discuss the various mechanisms that pseudokinases employ for nt binding and how this often low-affinity binding can be accurately analysed.

title: XXXX -binding mechanisms in pseudokinases.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity11064 :: ('CHEBI:29315', 'Chemical') :: ['phosphoryl']

answer: @entity4334 :: (D009711,Chemical) :: ['Nucleotide']


abstract: INTRODUCTION: @entity777 ( @entity777 ) is an important mediator of @entity32 . In addition to cells involved in @entity32 , sensory nociceptive neurons express the @entity777 signal-transducer @entity9683 ( @entity9683 ). These neurons are not only involved in @entity158 generation but also produce @entity13624 by release of neuropeptides such as @entity12819 ( @entity12819 ). Whether @entity777 activation of sensory neurons contributes to the induction of @entity32 is unknown. This study explored whether the action of @entity777 on sensory neurons plays a role in the generation of @entity13624 and @entity625 induction. METHODS: In SNS- @entity9683 (-/-) @entity19 lacking @entity9683 selectively in sensory neurons and appropriate control littermates (SNS- @entity9683 (flox/flox)), we induced @entity625 ( @entity625 ), and assessed @entity4 , histopathological @entity625 scores, @entity158 scores, expression of @entity12819 in sensory neurons, serum concentrations of @entity12819 and cytokines, and the cytokine release from single cell suspensions from lymph nodes and spleens. In wild-type @entity19 @entity12819 release was determined during development of @entity625 and, in cultured sensory neurons, upon @entity777 stimulation. RESULTS: Compared to SNS- @entity9683 (flox/flox) @entity19 SNS- @entity9683 (-/-) @entity19 showed significantly weaker @entity4 , reduced serum concentrations of @entity12819 , @entity777 , and @entity2047 , no @entity32 -evoked upregulation of @entity12819 in sensory neurons, but similar histopathological @entity625 scores during @entity625 . During the @entity4 phase of @entity625 , @entity12819 was significantly increased in the serum, knee and spleen. In vitro, @entity777 augmented the release of @entity12819 from cultured sensory neurons. Upon antigen-specific restimulation lymphocytes from SNS- @entity9683 (-/-) @entity19 released more interleukin-17 and interferon-y than lymphocytes from SNS- @entity9683 (flox/flox) @entity19 . In naive lymphocytes from SNS- @entity9683 (flox/flox) and SNS- @entity9683 (-/-) @entity19 @entity12819 reduced the release of @entity2047 (a cytokine which inhibits the release of interleukin-17 and interferon-y). CONCLUSIONS: @entity777 signaling in sensory neurons plays a role in the expression of @entity625 . Selective deletion of @entity9683 signaling in sensory neurons reduces the @entity4 of the joint (most likely by reducing @entity13624 ) but increases some proinflammatory systemic cellular responses such as the release of interleukin-17 and interferon-y from lymphocytes upon antigen-specific restimulation. Thus @entity777 signaling in sensory neurons is not only involved in @entity158 generation but also in the coordination of the inflammatory response.

title: @entity777 -dependent influence of nociceptive sensory neurons on XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['antigen-induced arthritis', 'AIA', 'arthritis']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['initial swelling', 'swelling']

entities_list: @entity12819 :: ('12310(Tax:10090)', 'Gene') :: ['CGRP', 'calcitonin gene-related peptide']

entities_list: @entity13624 :: ('MESH:D020078', 'Disease') :: ['neurogenic inflammation']

answer: @entity625 :: (MESH:D001168,Disease) :: ['antigen-induced arthritis']


abstract: INTRODUCTION: @entity777 ( @entity777 ) is an important mediator of @entity32 . In addition to cells involved in @entity32 , sensory nociceptive neurons express the @entity777 signal-transducer @entity9683 ( @entity9683 ). These neurons are not only involved in @entity158 generation but also produce @entity13624 by release of neuropeptides such as @entity12819 ( @entity12819 ). Whether @entity777 activation of sensory neurons contributes to the induction of @entity32 is unknown. This study explored whether the action of @entity777 on sensory neurons plays a role in the generation of @entity13624 and @entity625 induction. METHODS: In SNS- @entity9683 (-/-) @entity19 lacking @entity9683 selectively in sensory neurons and appropriate control littermates (SNS- @entity9683 (flox/flox)), we induced @entity625 ( @entity625 ), and assessed @entity4 , histopathological @entity625 scores, @entity158 scores, expression of @entity12819 in sensory neurons, serum concentrations of @entity12819 and cytokines, and the cytokine release from single cell suspensions from lymph nodes and spleens. In wild-type @entity19 @entity12819 release was determined during development of @entity625 and, in cultured sensory neurons, upon @entity777 stimulation. RESULTS: Compared to SNS- @entity9683 (flox/flox) @entity19 SNS- @entity9683 (-/-) @entity19 showed significantly weaker @entity4 , reduced serum concentrations of @entity12819 , @entity777 , and @entity2047 , no @entity32 -evoked upregulation of @entity12819 in sensory neurons, but similar histopathological @entity625 scores during @entity625 . During the @entity4 phase of @entity625 , @entity12819 was significantly increased in the serum, knee and spleen. In vitro, @entity777 augmented the release of @entity12819 from cultured sensory neurons. Upon antigen-specific restimulation lymphocytes from SNS- @entity9683 (-/-) @entity19 released more interleukin-17 and interferon-y than lymphocytes from SNS- @entity9683 (flox/flox) @entity19 . In naive lymphocytes from SNS- @entity9683 (flox/flox) and SNS- @entity9683 (-/-) @entity19 @entity12819 reduced the release of @entity2047 (a cytokine which inhibits the release of interleukin-17 and interferon-y). CONCLUSIONS: @entity777 signaling in sensory neurons plays a role in the expression of @entity625 . Selective deletion of @entity9683 signaling in sensory neurons reduces the @entity4 of the joint (most likely by reducing @entity13624 ) but increases some proinflammatory systemic cellular responses such as the release of interleukin-17 and interferon-y from lymphocytes upon antigen-specific restimulation. Thus @entity777 signaling in sensory neurons is not only involved in @entity158 generation but also in the coordination of the inflammatory response.

title: XXXX -dependent influence of nociceptive sensory neurons on @entity625 .

answer: @entity777 :: (16193(Tax:10090),Gene) :: ['Interleukin-6']


abstract: UNASSIGNED: Essential oil extracted from Chamaecyparis obtusa (EOCO) consists of several @entity199 with anti-inflammatory effects. @entity199 are expected to have an analgesic effect through inhibition of pro-inflammatory mediators. The present study investigated the anti-nociceptive and anti-inflammatory effects of EOCO in animal models of @entity158 . Intraperitoneal injection with EOCO (5 or 10mg/kg), @entity117 (positive control, 300mg/kg), or @entity3733 (negative control) was performed 1h before the nociception tests: @entity1543 -induced writhing response, @entity406 test, and hot plate test in @entity19 , and acidic saline-induced @entity1931 in @entity35 . The expression of pro-inflammatory cytokines and pro-inflammatory enzymes in @entity406 -injected paws was determined by ELISA and western blotting, respectively. Treatment with EOCO significantly reduced @entity1543 -induced writhing and paw-licking time in late response of the @entity406 tests. The anti-nociceptive effect was comparable with @entity117 . However, EOCO did not affect the reaction time of licking of the hind paws or jumping in hot plate test and the mechanical withdrawal thresholds in acidic saline-induced @entity1931 model. @entity406 -injected paws of @entity19 treated with EOCO revealed the down-regulated expression of @entity5 @entity39 factor-a, @entity635 , inducible @entity842 synthase, and @entity1996 , as compared with those of control @entity19 . These data showed the anti-nociceptive and anti-inflammatory effects of EOCO. The @entity158 -relieving effect might be attributed to inhibition of peripheral @entity158 in association with inflammatory response. EOCO could be a useful therapeutic strategy to manage @entity158 and @entity32 .

title: Antinociceptive and anti-inflammatory effects of essential oil extracted from Chamaecyparis obtusa in XXXX .

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory diseases']

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['allodynia']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity199 :: ('MESH:D039821', 'Chemical') :: ['Monoterpenes', 'monoterpenes']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formalin', 'Formalin']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: PURPOSE: Results of a study of an opioid-sparing protocol for acute @entity158 management in the @entity341 ( @entity341 ) are reported. METHODS: The @entity341 of a large hospital conducted a project, the "Opioid-Free Shift," to test a multimodal pharmacologic approach to analgesic therapy as an alternative to routine use of opioids. During a specified eight-hour period, all adults arriving at the @entity341 with a complaint of @entity158 were treated according to an opioid-sparing protocol based on principles of channel enzyme receptor-targeted analgesia (CERTA). @entity158 severity was assessed at baseline and at 30 and 60 minutes after analgesia administration using a validated rating scale. RESULTS: Seventeen @entity1 were treated in the @entity341 for acute or @entity1118 during the study period. The median @entity158 score on the 11-point rating scale was 8 (range, 4-10) at baseline, declining to 6 (range, 0-10) at 30 minutes and to 5 (range, 1-10) at 60 minutes. At 30 minutes, 7 @entity1 (41%) had a @entity158 score reduction of >= 30% and 3 (18%) had a reduction of >= 50%. Six of the 15 @entity1 (40%) reassessed at 60 minutes had a @entity158 score reduction of >= 30%; 4 @entity1 (27%) had a reduction of >= 50%. More than 80% of @entity1 were satisfied with the @entity158 relief provided through the CERTA-based protocol, and no adverse drug reactions were reported. CONCLUSION: The 17 @entity1 treated for acute or @entity1118 during the opioid-free shift were managed mainly with i.v. @entity6058 and oral @entity5018 , with only 1 @entity1 requiring rescue opioid therapy.

title: Development of an opioid reduction protocol in an XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity5018 :: ('MESH:D007052', 'Chemical') :: ['ibuprofen']

entities_list: @entity6058 :: ('MESH:D020910', 'Chemical') :: ['ketorolac']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

answer: @entity341 :: (MESH:D004630,Disease) :: ['emergency department']


abstract: UNASSIGNED: Risk factors for adolescent overweight and @entity28 include low levels of physical activity, high levels of sedentary behavior, low fruit and vegetable intake, and low socioeconomic position (SEP). To date, the vast majority of research investigating associations between lifestyle behaviors and weight status analyze dietary and time use factors separately. Our research aimed to describe Australian youth time use and diet clusters and explore relationships with weight status and SEP (parental education and income). Cluster analysis of the National @entity1 's Nutrition and Physical Activity Survey data from Australians aged 9 to 16 years (random sample n = 1,853) was conducted. Time use data (17 age-adjusted time use variables) and dietary data (7 age-adjusted diet variables) were collected via 24-hour recalls. Two clusters were associated with a reduced frequency of overweight and @entity28 (the @entity1 ' Active Sitter and @entity1 ' Healthy @entity4207 ) and one with an increased frequency of overweight and @entity28 (the @entity1 ' Unhealthy cluster). Of these three clusters, two demonstrated associations with parental income and/or parental education level. The @entity1 ' Unhealthy cluster was associated with low SEP status (parental income and education), and the @entity1 ' Healthy Academic cluster was associated with high parental income. Not all unhealthy adolescent clusters were associated with overweight and @entity28 . The findings suggest sex-specific diet and activity clusters can be used to identify at-risk subgroups and inform multifaceted interventions to address overweight and @entity28 .

title: Adolescent Diet and Time Use Clusters and Associations With XXXX and Socioeconomic Position.

entities_list: @entity1 :: ('9606', 'Species') :: ['Children', 'girls', 'boys']

entities_list: @entity4207 :: ('MESH:D007859', 'Disease') :: ['Academic clusters']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['Overweight and Obesity']


abstract: BACKGROUND: Recent guidelines recommend the @entity4309 prediction models MMRPredict, MMRPro, and PREMM1,2,6 for the identification of MMR gene mutation carriers. We compared the predictive performance and clinical usefulness of these prediction models to identify mutation carriers. METHODS: Pedigree data from @entity14 @entity1 in 11 North American, European, and Australian cohorts (6 clinic- and 5 population-based sites) were used to calculate predicted probabilities of pathogenic @entity6756 , @entity4311 , or @entity4638 gene mutations by each model and gene-specific predictions by MMRPro and PREMM1,2,6. We examined discrimination with area under the receiver operating characteristic curve (AUC), calibration with observed to expected (O/E) ratio, and clinical usefulness using decision curve analysis to select @entity1 for further evaluation. All statistical tests were two-sided. RESULTS: Mutations were detected in 539 of 2304 (23%) individuals from the clinic-based cohorts (237 @entity6756 , 251 @entity4311 , 51 @entity4638 ) and 150 of 3451 (4.4%) individuals from the population-based cohorts (47 @entity6756 , 71 @entity4311 , 32 @entity4638 ). Discrimination was similar for clinic- and population-based cohorts: AUCs of 0.76 vs 0.77 for MMRPredict, 0.82 vs 0.85 for MMRPro, and 0.85 vs 0.88 for PREMM1,2,6. For clinic- and population-based cohorts, O/E deviated from 1 for MMRPredict (0.38 and 0.31, respectively) and MMRPro (0.62 and 0.36) but were more satisfactory for PREMM1,2,6 (1.0 and 0.70). MMRPro or PREMM1,2,6 predictions were clinically useful at thresholds of 5% or greater and in particular at greater than 15%. CONCLUSIONS: MMRPro and PREMM1,2,6 can well be used to select @entity14 @entity1 from genetics clinics or population-based settings for @entity5 and/or germline testing at a 5% or higher risk. If no @entity5527 is detected and risk exceeds 15%, we suggest considering additional genetic etiologies for the cause of @entity5 in the family.

title: Comparison of Prediction Models for XXXX Among Individuals With @entity14 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4309 :: ('MESH:D003123', 'Disease') :: ['Lynch Syndrome']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity5527 :: ('MESH:C536928', 'Disease') :: ['MMR deficiency']

answer: @entity4309 :: (MESH:D003123,Disease) :: ['Lynch Syndrome']


abstract: BACKGROUND: Recent guidelines recommend the @entity4309 prediction models MMRPredict, MMRPro, and PREMM1,2,6 for the identification of MMR gene mutation carriers. We compared the predictive performance and clinical usefulness of these prediction models to identify mutation carriers. METHODS: Pedigree data from @entity14 @entity1 in 11 North American, European, and Australian cohorts (6 clinic- and 5 population-based sites) were used to calculate predicted probabilities of pathogenic @entity6756 , @entity4311 , or @entity4638 gene mutations by each model and gene-specific predictions by MMRPro and PREMM1,2,6. We examined discrimination with area under the receiver operating characteristic curve (AUC), calibration with observed to expected (O/E) ratio, and clinical usefulness using decision curve analysis to select @entity1 for further evaluation. All statistical tests were two-sided. RESULTS: Mutations were detected in 539 of 2304 (23%) individuals from the clinic-based cohorts (237 @entity6756 , 251 @entity4311 , 51 @entity4638 ) and 150 of 3451 (4.4%) individuals from the population-based cohorts (47 @entity6756 , 71 @entity4311 , 32 @entity4638 ). Discrimination was similar for clinic- and population-based cohorts: AUCs of 0.76 vs 0.77 for MMRPredict, 0.82 vs 0.85 for MMRPro, and 0.85 vs 0.88 for PREMM1,2,6. For clinic- and population-based cohorts, O/E deviated from 1 for MMRPredict (0.38 and 0.31, respectively) and MMRPro (0.62 and 0.36) but were more satisfactory for PREMM1,2,6 (1.0 and 0.70). MMRPro or PREMM1,2,6 predictions were clinically useful at thresholds of 5% or greater and in particular at greater than 15%. CONCLUSIONS: MMRPro and PREMM1,2,6 can well be used to select @entity14 @entity1 from genetics clinics or population-based settings for @entity5 and/or germline testing at a 5% or higher risk. If no @entity5527 is detected and risk exceeds 15%, we suggest considering additional genetic etiologies for the cause of @entity5 in the family.

title: Comparison of Prediction Models for @entity4309 Among Individuals With XXXX .

answer: @entity14 :: (MESH:D015179,Disease) :: ['Colorectal Cancer']


abstract: AIM: To develop a statistical index based on the phase space reconstruction (PSR) of the electrocardiogram (ECG) for the accurate and timely diagnosis of @entity1165 ( @entity1165 ) and @entity2224 ( @entity2224 ). METHODS: Thirty-two ECGs with sinus rhythm (SR) and 32 ECGs with @entity1165 / @entity2224 were analyzed using the PSR technique. Firstly, the method of time delay embedding were employed with the insertion of delay "  " in the original time-series X(t), which produces the Y(t)=X(t-  ). Afterwards, a PSR diagram was reconstructed by plotting Y(t) against X(t). The method of box counting was applied to analyze the behavior of the PSR trajectories. Measures as mean ( ), standard deviation (  ) and coefficient of variation (CV=  / ), kurtosis (b) for the box counting of PSR diagrams were reported. RESULTS: During SR, CV was always <0.05, while with the onset of @entity943 CV increased >0.05. A similar pattern was observed with b, where <6 was considered as the cut-off point between SR and @entity1165 / @entity2224 . Therefore, the upper threshold for SR was considered CVth=0.05 and bth<6. For optimisation of the accuracy, a new index (J) was proposed: J=wCVCVth+1-wbbth. During SR the upper limit of J was the value of 1. Furthermore CV, b and J crossed the cut-off point timely before the onset of @entity943 (average time: 4min 31s; SD: 2min 30s); allowing sufficient time for preventive therapy. CONCLUSION: The J index improved ECG utility for @entity943 monitoring and detection utility, allowing the prompt and accurate diagnosis of @entity943 .

title: Prompt and accurate diagnosis of XXXX with a novel index based on phase space reconstruction of ECG.

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias', 'arrhythmia']

entities_list: @entity1165 :: ('MESH:D017180', 'Disease') :: ['VT', 'ventricular tachycardia']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['VF', 'ventricular fibrillation']

answer: @entity943 :: (MESH:D001145,Disease) :: ['ventricular arrhythmias']


abstract: @entity1723 ( @entity1723 ) is a @entity102 characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed @entity8923 levels in the plasma of juveniles with @entity1723 . Compared to control subjects, @entity8923 levels were significantly elevated in @entity1 with @entity1723 . On the other hand, levels of @entity10454 ( @entity10454 ) and @entity21264 , two negative regulators of @entity8923 function, remained unchanged when comparing @entity1723 to control samples. Notably, however, although @entity10454 levels were not elevated, @entity8923 and @entity10454 were found to be positively correlated in type 1 @entity6 . Even so, free, unbound @entity8923 remained significantly increased in @entity6 @entity1 . Additionally, correlation studies also revealed that @entity8923 and @entity10454 are positively correlated with HbA1c levels in @entity1723 @entity1 , suggesting a potential link between @entity8923 and metabolic control in these @entity1 . Finally, we observed a significant increase in @entity8923 protein expression within @entity1 pancreatic islet specimens collected from type 1 @entity6 . These results further expand our knowledge of the role of @entity8923 in @entity1723 , may give insight into common pathogenic mechanisms associated with metabolic control in both @entity1723 and T2D, and suggest that targeting this cytokine may improve therapeutic outcomes for @entity1723 @entity1 .

title: Increased expression of @entity8923 in the serum and islets of type 1 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetics', 'diabetic']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic disease']

entities_list: @entity1723 :: ('MESH:D003922', 'Disease') :: ['Type 1 diabetes', 'T1D']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetics']


abstract: @entity1723 ( @entity1723 ) is a @entity102 characterized by autoimmune-mediated destruction of pancreatic insulin-producing beta cells. Interleukin (IL)-18 is a pro-inflammatory cytokine implicated in the pathogenesis of a number of inflammatory diseases. Here, we analyzed @entity8923 levels in the plasma of juveniles with @entity1723 . Compared to control subjects, @entity8923 levels were significantly elevated in @entity1 with @entity1723 . On the other hand, levels of @entity10454 ( @entity10454 ) and @entity21264 , two negative regulators of @entity8923 function, remained unchanged when comparing @entity1723 to control samples. Notably, however, although @entity10454 levels were not elevated, @entity8923 and @entity10454 were found to be positively correlated in type 1 @entity6 . Even so, free, unbound @entity8923 remained significantly increased in @entity6 @entity1 . Additionally, correlation studies also revealed that @entity8923 and @entity10454 are positively correlated with HbA1c levels in @entity1723 @entity1 , suggesting a potential link between @entity8923 and metabolic control in these @entity1 . Finally, we observed a significant increase in @entity8923 protein expression within @entity1 pancreatic islet specimens collected from type 1 @entity6 . These results further expand our knowledge of the role of @entity8923 in @entity1723 , may give insight into common pathogenic mechanisms associated with metabolic control in both @entity1723 and T2D, and suggest that targeting this cytokine may improve therapeutic outcomes for @entity1723 @entity1 .

title: Increased expression of XXXX in the serum and islets of type 1 @entity6 .

answer: @entity8923 :: (3606,Gene) :: ['IL-18']


abstract: UNASSIGNED: Upper @entity1820 originating in the oesophagus and stomach often present late and have a very poor prognosis. Treatment options include surgery for localised disease but, increasingly, neoadjuvant chemotherapy and radiotherapy is being employed to improve outcome. There is often a variable response to neoadjuvant treatment between individual @entity1 and side effects are relatively common. There is an urgent need for novel biomarkers of upper @entity1820 , not only to improve screening and early diagnosis of the oesophageal and @entity356 when treatment options are potentially more effective, but also to accurately guide therapy in more @entity1442 . The development of predictive biomarkers will also help to more effectively identify those @entity1 that will benefit from targeted therapies. Although many promising results have been derived from these studies there remains a lack of validated clinically applicable biomarkers available for translation into routine clinical use. This review will provide an overview of the recent proteomic research on upper @entity1820 protein biomarker identification and validation. The challenges faced in the development of validated, clinically acceptable and accurate protein biomarkers will also be discussed, along with possible areas of future progress. This article is protected by copyright. All rights reserved.

title: Progress in the development of protein biomarkers of oesophageal and XXXX .

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancers', 'gastrointestinal cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancers']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric cancers']


abstract: UNASSIGNED: @entity3676 ( @entity71410 ) and @entity14053 ( @entity14054 ) are common ingredients in household bathroom and kitchen cleaning sprays. @entity71410 + @entity14054 cause reproductive @entity137 in @entity19 . The aim of the present study was to investigate gender-specific reproductive effects from @entity71410 + @entity14054 . Female reproduction was assessed through ovulation, oocyte implantation, and estrus cycling. Male reproductive function was assessed by sperm concentration, motility, and viability. Numbers of corpora lutea were not different after 2 weeks, but decreased after 8 weeks of @entity71410 + @entity14054 exposure. Dams exposed for 5 weeks to @entity71410 + @entity14054 spent significantly less time in estrus. @entity71410 + @entity14054 exposed males exhibited declines in both sperm concentration and motility, but not sperm viability. @entity249 in @entity19 from @entity71410 + @entity14054 exposure is, therefore, mediated through reproductive disturbances in both females and males. While the effect of @entity71410 + @entity14054 exposure on @entity1 health is unclear, widespread exposure necessitates further consideration of their potential reproductive @entity137 .

title: Quaternary ammonium disinfectants cause XXXX in @entity19 by targeting both male and female reproductive processes.

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['Subfertility']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity14053 :: ('MESH:C027118', 'Chemical') :: ['didecyl dimethyl ammonium chloride']

entities_list: @entity3676 :: ('MESH:D001548', 'Chemical') :: ['Alkyl dimethyl benzyl ammonium chloride']

answer: @entity249 :: (MESH:D007246,Disease) :: ['subfertility']


abstract: UNASSIGNED: @entity3676 ( @entity71410 ) and @entity14053 ( @entity14054 ) are common ingredients in household bathroom and kitchen cleaning sprays. @entity71410 + @entity14054 cause reproductive @entity137 in @entity19 . The aim of the present study was to investigate gender-specific reproductive effects from @entity71410 + @entity14054 . Female reproduction was assessed through ovulation, oocyte implantation, and estrus cycling. Male reproductive function was assessed by sperm concentration, motility, and viability. Numbers of corpora lutea were not different after 2 weeks, but decreased after 8 weeks of @entity71410 + @entity14054 exposure. Dams exposed for 5 weeks to @entity71410 + @entity14054 spent significantly less time in estrus. @entity71410 + @entity14054 exposed males exhibited declines in both sperm concentration and motility, but not sperm viability. @entity249 in @entity19 from @entity71410 + @entity14054 exposure is, therefore, mediated through reproductive disturbances in both females and males. While the effect of @entity71410 + @entity14054 exposure on @entity1 health is unclear, widespread exposure necessitates further consideration of their potential reproductive @entity137 .

title: Quaternary ammonium disinfectants cause @entity249 in XXXX by targeting both male and female reproductive processes.

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: PURPOSE: @entity933 ( @entity933 ) is a common @entity260 of ambulatory pediatric surgery done under general anesthesia with @entity2614 . However, perioperative analgesic techniques have been shown to reduce @entity2614 -induced @entity933 . The primary objective of this investigation was to examine whether an ultrasound-guided ilioinguinal/iliohypogastric (II/IH) @entity616 for ambulatory pediatric @entity169 could reduce the incidence of @entity2614 -induced @entity933 . METHODS: The subjects of this prospective randomized double-blind study were 40 @entity1 ranging in age from 1 to 6  years, who were scheduled to undergo ambulatory @entity169 . The @entity1 were randomized to either receive or not to receive an ultrasound-guided II/IH @entity616 (Group B and Group NB, respectively). General anesthesia was maintained with @entity2614 and @entity3810 . The primary outcome assessed was @entity933 , evaluated using the Pediatric Anesthesia Emergence @entity933 (PAED) scale 30  min after emergence from general anesthesia. The secondary outcomes assessed were @entity282 , evaluated using the @entity158 ( @entity158 ), and the amount of intra-operative @entity2614 given. RESULTS: The median PAED scale scores did not differ between Groups B and NB at 30  min (P  =  0.41). @entity158 scores also did not differ significantly between the groups, but the mean amount of intraoperative @entity2614 given was significantly lower in Group B than in Group NB (P  <  0.01). CONCLUSIONS: Ultrasound-guided II/IH @entity616 for ambulatory pediatric @entity169 did not reduce @entity933 , but it did decrease the amount of intra-operative @entity2614 needed. CLINICAL TRIAL REGISTRATION: UMIN000008586.

title: Ultrasound-guided ilioinguinal/iliohypogastric block did not reduce emergence @entity933 after ambulatory pediatric XXXX : a prospective randomized double-blind study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'boys']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complication']

entities_list: @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide']

entities_list: @entity2614 :: ('MESH:C009250', 'Chemical') :: ['sevoflurane']

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['ED', 'Delirium', 'Emergence delirium']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['BOPS', 'Behavioral Observational Pain Scale']

entities_list: @entity169 :: ('MESH:D006552', 'Disease') :: ['inguinal hernia repair']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['nerve block']

answer: @entity169 :: (MESH:D006552,Disease) :: ['inguinal hernia repair']


abstract: PURPOSE: @entity933 ( @entity933 ) is a common @entity260 of ambulatory pediatric surgery done under general anesthesia with @entity2614 . However, perioperative analgesic techniques have been shown to reduce @entity2614 -induced @entity933 . The primary objective of this investigation was to examine whether an ultrasound-guided ilioinguinal/iliohypogastric (II/IH) @entity616 for ambulatory pediatric @entity169 could reduce the incidence of @entity2614 -induced @entity933 . METHODS: The subjects of this prospective randomized double-blind study were 40 @entity1 ranging in age from 1 to 6  years, who were scheduled to undergo ambulatory @entity169 . The @entity1 were randomized to either receive or not to receive an ultrasound-guided II/IH @entity616 (Group B and Group NB, respectively). General anesthesia was maintained with @entity2614 and @entity3810 . The primary outcome assessed was @entity933 , evaluated using the Pediatric Anesthesia Emergence @entity933 (PAED) scale 30  min after emergence from general anesthesia. The secondary outcomes assessed were @entity282 , evaluated using the @entity158 ( @entity158 ), and the amount of intra-operative @entity2614 given. RESULTS: The median PAED scale scores did not differ between Groups B and NB at 30  min (P  =  0.41). @entity158 scores also did not differ significantly between the groups, but the mean amount of intraoperative @entity2614 given was significantly lower in Group B than in Group NB (P  <  0.01). CONCLUSIONS: Ultrasound-guided II/IH @entity616 for ambulatory pediatric @entity169 did not reduce @entity933 , but it did decrease the amount of intra-operative @entity2614 needed. CLINICAL TRIAL REGISTRATION: UMIN000008586.

title: Ultrasound-guided ilioinguinal/iliohypogastric block did not reduce emergence XXXX after ambulatory pediatric @entity169 : a prospective randomized double-blind study.

answer: @entity933 :: (MESH:D003693,Disease) :: ['delirium']