abstract: UNASSIGNED: In some conditions, female sexual behavior in ovariectomized @entity35 can be induced by continuous exposure of @entity53 (E2) alone or by a single injection of a high dose of the long-lasting, esterified @entity4520 (EB). However, there are inconsistencies in the literature on the role of @entity172 during priming or in the facilitation on female sexual behavior in EB-primed @entity35 , as well as the cellular mechanisms involved. Either subcutaneous (sc) or intracerebral (icv) administration of some doses of free unesterified E2, induced @entity1515 in EB-primed @entity35 . Either sc or icv injection of E2, immediately prior to testing, induced high levels of sexual receptivity when the female @entity35 were primed with an EB sc injection of 2  g EB. The roles of @entity1420 receptor (PR) and @entity172 receptor on @entity1515 induced by sc or icv administration of E2 were explored. @entity440 or @entity3927 administrated sc or icv; each reduced @entity1515 induced by E2. Similarly, antisense oligonucleotides directed at @entity27557 or total PR (PR-A + @entity27557 ) administrated icv immediately before EB injection inhibited @entity1515 induced by daily injections of EB. These results suggest that @entity1515 facilitated by free E2 is dependent on priming dose of EB. Furthermore both ERs and PRs are involved in this action of E2. (PsycINFO Database Record

title: Sexual Receptivity Facilitated by Unesterified XXXX : Dependence on @entity172 and Progestin Receptors and Priming Dose of @entity4520 .

answer: @entity53 :: (MESH:D004958,Chemical) :: ['Estradiol']


abstract: UNASSIGNED: In some conditions, female sexual behavior in ovariectomized @entity35 can be induced by continuous exposure of @entity53 (E2) alone or by a single injection of a high dose of the long-lasting, esterified @entity4520 (EB). However, there are inconsistencies in the literature on the role of @entity172 during priming or in the facilitation on female sexual behavior in EB-primed @entity35 , as well as the cellular mechanisms involved. Either subcutaneous (sc) or intracerebral (icv) administration of some doses of free unesterified E2, induced @entity1515 in EB-primed @entity35 . Either sc or icv injection of E2, immediately prior to testing, induced high levels of sexual receptivity when the female @entity35 were primed with an EB sc injection of 2  g EB. The roles of @entity1420 receptor (PR) and @entity172 receptor on @entity1515 induced by sc or icv administration of E2 were explored. @entity440 or @entity3927 administrated sc or icv; each reduced @entity1515 induced by E2. Similarly, antisense oligonucleotides directed at @entity27557 or total PR (PR-A + @entity27557 ) administrated icv immediately before EB injection inhibited @entity1515 induced by daily injections of EB. These results suggest that @entity1515 facilitated by free E2 is dependent on priming dose of EB. Furthermore both ERs and PRs are involved in this action of E2. (PsycINFO Database Record

title: Sexual Receptivity Facilitated by Unesterified @entity53 : Dependence on XXXX and Progestin Receptors and Priming Dose of @entity4520 .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen', 'estrogens']

entities_list: @entity440 :: ('MESH:D013629', 'Chemical') :: ['Tamoxifen']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['estradiol']

entities_list: @entity4520 :: ('MESH:C074283', 'Chemical') :: ['estradiol benzoate']

answer: @entity172 :: (MESH:D004967,Chemical) :: ['Estrogen']


abstract: BACKGROUND: Complete revascularisation (CR) by means of percutaneous coronary intervention (PCI) has been associated with better long-term prognosis than incomplete revascularisation (IR) in several clinical trials. However, in the published studies, the completeness of @entity296 has been judged mainly on an anatomical basis, while including criteria directed at functionally driven IR might lead to different results. AIM: To examine the potential value of functionally driven IR in a large cohort of @entity1 with multivessel @entity453 (MVD) undergoing PCI. METHODS: The study population consisted of 908 @entity1 with MVD undergoing PCI without stenting between 1988 and 1997. Functionally driven IR was defined as dilation of all segments with >70% stenosis, with the exception of arteries supplying an area of previous transmural @entity583 ( @entity583 ) or a small amount of myocardium. Complete revascularisation was defined as successful PCI of all coronary artery lesions with significant narrowing not fulfilling the above criteria. @entity1 were followed for a mean 11 years (range 8-16 years). End-points included: death, @entity583 , re-PCI or coronary artery bypass grafting (CABG). RESULTS: Complete revascularisation was performed in 284 (31.3%) @entity1 . Follow-up was obtained from 873 (96.1%) @entity1 . There was no significant difference in the frequency of all-cause mortality, @entity65 or @entity583 between @entity1 who underwent CR and IR. @entity1 who underwent IR were more likely to require re-PCI and had a trend toward more frequent CABG. CONCLUSIONS: In comparison to CR, a strategy of functionally driven IR by means of PCI without stenting does not increase the rate of major cardiovascular outcomes, but is related to higher frequency of repeat procedures during a long-term follow-up.

title: Functionally driven complete vs incomplete revascularisation in multivessel XXXX --long-term results from a large cohort.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial revascularisation']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular deaths']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: OBJECTIVE: Endoscopic transmural drainage and necrosectomy (ETDN) is a promising alternative to percutaneous drainage and surgical intervention in the treatment of walled-off pancreatic and peripancreatic necroses (WONs). We assessed the outcome and safety profile of ETDN in a single-center @entity1 cohort. MATERIALS AND METHODS: In November 2005, ETDN for WON was introduced in our tertiary referral center. During a 6-year period (Nov 2005-Nov 2011), we retrospectively collected data on all @entity1 who underwent ETDN. RESULTS: Eighty-one @entity1 were treated with ETDN (median age 54, 52 @entity1 ). @entity5990 were the predominant etiology of @entity788 (41%), followed by alcohol (33%). Median time from debut of symptoms to first endoscopic treatment was 44 (9-246) days. Culture-proven infected @entity39 was found in 71% of the cases. Twenty-three @entity1 (28%) required admission in intensive care unit. The technical and clinical success rates were 99% and 89%, respectively. Procedure-related complications occurred in 10 (12%) @entity1 , of which 1 was procedure-related @entity204 . In-hospital mortality was 11%. CONCLUSION: ETDN in @entity1 with @entity788 and infected @entity39 performed in a single, high-volume center has an acceptable safety profile and is associated with a low mortality.

title: Endoscopic, transmural drainage and necrosectomy for walled-off pancreatic and peripancreatic XXXX is associated with low mortality - a single-center experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'men']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis', 'necrotizing pancreatitis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5990 :: ('MESH:D042882', 'Disease') :: ['Gallstones']

answer: @entity39 :: (MESH:D009336,Disease) :: ['necrosis']


abstract: BACKGROUND: @entity9821 ( @entity9821 ) is rare. The risk of progression to @entity1252 ( @entity1252 ) is uncertain. OBJECTIVE: We sought to determine the risk of progression of pediatric @entity9821 to @entity1252 and to characterize its phenotype. METHODS: This was a retrospective review of 40 @entity1 with @entity9821 . RESULTS: Six (15%) of 40 @entity1 presented with @entity9821 as a manifestation of concurrent @entity1252 . Of the remaining 34, 9 (26%) eventually met @entity1252 criteria and 15 (44%) developed @entity854 without meeting @entity1252 criteria. Only 10 (29%) maintained skin-limited disease. The average age at progression to @entity1252 was 11 years, with greatest risk in the first year after @entity9821 diagnosis. Most (89%) @entity1 with @entity1252 met diagnostic criteria with @entity66 ( @entity75 , @entity1910 , oral and nasal ulcers, photosensitivity), positive antibodies, and/or @entity1503 without developing end-organ damage over 5 years of median follow-up. LIMITATIONS: The study was retrospective. CONCLUSIONS: In pediatric @entity1 , @entity9821 carries a significant risk of progression to @entity1252 but may predict a milder phenotype of @entity262 . All @entity1 require careful monitoring for @entity1252 , particularly within the first year of diagnosis.

title: The natural history of pediatric-onset XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['mucocutaneous disease']

entities_list: @entity1910 :: ('MESH:D005076', 'Disease') :: ['malar rash']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['discoid lesions']

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus']

entities_list: @entity9821 :: ('MESH:D008179', 'Disease') :: ['DLE', 'Pediatric discoid lupus erythematosus']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity1503 :: ('MESH:D006402', 'Disease') :: ['cytopenia']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['laboratory abnormalities']

answer: @entity9821 :: (MESH:D008179,Disease) :: ['discoid lupus erythematosus']


abstract: AIM: Heavy @entity548 is one of the common health problems in @entity1 . The first-line therapy of heavy @entity548 is the medical therapy, but this is not successful. Currently, global ablation procedures were introduced for treating of heavy @entity548 . The aim of this study was to the analysis of the @entity1 with @entity931 performed operations of Cavaterm in our university affiliated hospital, and explores its effectiveness and acceptability. METHODS: A retrospective study was conducted on 30 @entity1 with @entity931 who were unresponsive to hormone therapy or not candidates for hysterectomy underwent endometrial ablation using Cavaterm. Preoperative and postoperative PBAC Scoring System was used to assess @entity931 . Outcome measures were @entity2588 rates, reduction of menstrual flow rates, heavy @entity548 , menstrual and @entity1 ' satisfaction rates at 3, 6 and 12 months postoperative. RESULTS: After a follow-up at 3, 6, and 12 months postoperative, 36.7%, 43.3%, and 36.7% of @entity1 had a @entity3556 , respectively. @entity2588 rates were 56.7%, 50.0%, and 56.7% in the Cavaterm at 3, 6, and 12 months. The rate of @entity1 's reported good or excellent satisfaction was 93.3% in 12 months. During the follow-up period, no @entity1 received a subsequent hysterectomy. CONCLUSION: The findings of this research indicated that outcome with the Cavaterm was as good for @entity1 with @entity931 . Therefore, it is necessary to emphasize on lower operative and post-operative procedural risk and a deleterious effect on @entity1 who were unresponsive to hormone therapy.

title: Thermal balloon endometrial ablation in the treatment of heavy XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'woman', 'patients', 'patient']

entities_list: @entity3556 :: ('MESH:D014592', 'Disease') :: ['reduction in vaginal bleeding']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['menstrual bleeding', 'bleeding']

entities_list: @entity931 :: ('MESH:D008595', 'Disease') :: ['menorrhagia']

entities_list: @entity2588 :: ('MESH:D000568', 'Disease') :: ['Amenorrhea', 'amenorrhea']

answer: @entity548 :: (MESH:D006470,Disease) :: ['menstrual bleeding']


abstract: BACKGROUND: Oxidative stress could play a role in the development of @entity1468 . There is some evidence to suggest that @entity620 and E supplements can reduce the risk of the disorder. We hypothesized its beneficial role in a group of pregnant @entity1 with essential @entity101 . METHODS: In this randomized controlled trial, we enrolled 50 pregnant @entity1 with essential @entity101 . We assigned the @entity1 1000 mg @entity620 and 400 IU natural @entity270 (RRR a @entity4793 ; n = 25), daily from the second trimester of pregnancy until delivery or no supplementation (n = 25). Our primary endpoint was development of superimposed @entity1468 , and main secondary endpoints were aggravation of @entity101 , need for admission, need to increase antihypertensive drugs, and small size for gestational age (<fifth customized birthweight centile). RESULTS: We analyzed 50 @entity1 who completed the study. The incidence of superimposed @entity1468 was similar in vitamin and control groups (8% [n = 2] vs 12% [n = 3], p = 1.000). @entity620 and E supplementation also did not prevent aggravation of @entity101 in group of @entity1 who took it (12% [n = 3] vs 32% [n = 8], p = 0.172). Small size for gestational age babies did not differ between groups (4% [n = 2] vs 6% [n = 3], p = 1.000). CONCLUSION: @entity620 and E supplementation does not prevent development of superimposed @entity1468 in @entity1 with essential @entity101 . Our results did not show any significant benefit of vitamin supplementation. There was some trend in lessening of @entity101 complications of pregnancy. Our results failed to find any correlation between development of superimposed @entity1468 and oxidative stress.

title: XXXX and E supplementation does not reduce the risk of superimposed PE in pregnancy.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity270 :: ('MESH:D014810', 'Chemical') :: ['vitamin E']

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['Vitamin C', 'vitamin C']

entities_list: @entity1468 :: ('MESH:D011225', 'Disease') :: ['preeclampsia']

entities_list: @entity4793 :: ('MESH:D024505', 'Chemical') :: ['tocopherol']

answer: @entity620 :: (MESH:D001205,Chemical) :: ['Vitamin C']


abstract: OBJECTIVE: Despite the fact that the total energy intake of Japanese @entity1 has decreased, the percentage of @entity28 @entity1 has increased. This suggests that the timing of meals is related to @entity28 . The purpose of the study was to investigate the relationship between the timing of meals and @entity28 , based on analyses of physical measurements, serum biochemical markers, nutrient intake, and lifestyle factors in the context of Chrononutrition. @entity1 AND METHODS: We analyzed data derived from 766 residents of Toon City (286 males and 480 females) aged 30 to 79 years who underwent detailed medical examinations between 2011 and 2013. These medical examinations included. (1) physical measurements (waist circumference, blood pressure, etc.); (2) serum biochemical markers (total @entity165 , etc.); (3) a detailed questionnaire concerning lifestyle factors such as family structure and daily habits (22 issues), exercise and eating habits (28 issues), @entity167 intake and smoking habits; (4) a food frequency questionnaire based on food groups (FFQg); and (5) a questionnaire concerning the times at which meals and snacks are consumed. RESULTS: The values for body mass index (BMI) and waist circumference were higher for @entity1 who ate dinner less than three hours before bedtime (<3-h group) than those who ate more than three hours before bedtime (>3-h group). The Chi-square test showed that there was a significant difference in eating habits, e.g., eating snacks, eating snacks at night, having dinner after 8 p.m., and having dinner after 9 p.m., between the <3-h group and the >3-h group. Multiple linear regression analysis showed that skipping breakfast significantly influenced both waist circumference (b = 5.271) and BMI (b = 1.440) and that eating dinner <3-h before going to bed only influenced BMI (b = 0.581). CONCLUSION: Skipping breakfast had a greater influence on both waist circumference and BMI than eating dinner <3-h before going to bed.

title: Skipping Breakfast is Correlated with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'PARTICIPANTS', 'people']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

answer: @entity28 :: (MESH:D009765,Disease) :: ['Obesity']


abstract: INTRODUCTION: Lumbar drainage for cerebrospinal fluid (CSF) diversion in @entity510 ( @entity510 ) has been reported to be beneficial in small series. There is no consensus regarding the optimal candidates for lumbar drainage, timing of drain placement, or amount and duration of CSF drainage. METHODS: We performed a comprehensive review of the English literature reporting series of @entity1 with @entity510 undergoing CSF diversion with lumbar drains. Favorable clinical outcome was defined as modified Rankin Scale of 0--2 or Glasgow Outcome Scale as 4--5. RESULTS: A total of 8 studies reporting on 841 @entity1 were included. Of these, 446 @entity1 were treated with lumbar drains. Two studies were prospective and five studies had comparison groups. Most @entity1 undergoing lumbar drainage were in good clinical grade on presentation (394/446, 88%) and the majority had substantial clot burden on head CT. Among the five studies with a comparison group, lumbar drainage was associated with lower rates of symptomatic @entity2553 or delayed @entity2806 (20% vs 45%, p<0.001) and higher rates of favorable outcome (79.4% vs. 60.4% p<0.001). The complication rate was 3.5%. CONCLUSION: Lumbar drainage in @entity510 appears to be safe and associated with reduced rates of symptomatic @entity2553 and improved clinical outcomes in @entity1 in good clinical grade with thick clot burden, but the quality of most available studies is weak. The optimal duration and rate of CSF diversion remains uncertain.

title: Lumbar drainage and delayed XXXX in @entity510 :a systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2553 :: ('MESH:D020301', 'Disease') :: ['vasospasm']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['aneurysmal subarachnoid hemorrhage', 'aSAH']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['cerebral ischemia']


abstract: INTRODUCTION: Lumbar drainage for cerebrospinal fluid (CSF) diversion in @entity510 ( @entity510 ) has been reported to be beneficial in small series. There is no consensus regarding the optimal candidates for lumbar drainage, timing of drain placement, or amount and duration of CSF drainage. METHODS: We performed a comprehensive review of the English literature reporting series of @entity1 with @entity510 undergoing CSF diversion with lumbar drains. Favorable clinical outcome was defined as modified Rankin Scale of 0--2 or Glasgow Outcome Scale as 4--5. RESULTS: A total of 8 studies reporting on 841 @entity1 were included. Of these, 446 @entity1 were treated with lumbar drains. Two studies were prospective and five studies had comparison groups. Most @entity1 undergoing lumbar drainage were in good clinical grade on presentation (394/446, 88%) and the majority had substantial clot burden on head CT. Among the five studies with a comparison group, lumbar drainage was associated with lower rates of symptomatic @entity2553 or delayed @entity2806 (20% vs 45%, p<0.001) and higher rates of favorable outcome (79.4% vs. 60.4% p<0.001). The complication rate was 3.5%. CONCLUSION: Lumbar drainage in @entity510 appears to be safe and associated with reduced rates of symptomatic @entity2553 and improved clinical outcomes in @entity1 in good clinical grade with thick clot burden, but the quality of most available studies is weak. The optimal duration and rate of CSF diversion remains uncertain.

title: Lumbar drainage and delayed @entity2806 in XXXX :a systematic review.

answer: @entity510 :: (MESH:D013345,Disease) :: ['aneurysmal subarachnoid hemorrhage']


abstract: @entity16826 fixed-dose regimens attained better kidney function and comparable efficacy to @entity205 ( @entity9472 ) in kidney transplant @entity1 , albeit with increased risks of certain adverse events. This post-hoc analysis evaluated whether a @entity1 subgroup with an acceptable risk-benefit profile could be identified. @entity16826 exposure was a statistically significant predictor of serious @entity281 rate. One-hundred and eighty six kidney transplant @entity1 were re-categorized to above-median (AME) or below-median (BME) exposure groups. The 6-month biopsy-proven acute rejection rates in AME, BME and @entity9472 groups were 7.8%, 15.7% and 17.7%, respectively. Measured glomerular filtration rate was higher in AME and BME groups versus @entity9472 (61.2 and 67.9 vs. 53.9   mL/min) at Month 12. Fewer @entity1 developed @entity82 and @entity194 (IF/TA) at Month 12 in AME (20.5%) and BME (27.8%) groups versus @entity9472 (48.3%). @entity281 occurred more frequently in the AME group (53.0%) than in BME (28.4%) or @entity9472 (25.5%) groups. @entity1071 ( @entity1071 ) only occurred in the AME group. In kidney transplant @entity1 , the BME group preserved the clinical advantage of comparable acute rejection rates, improved renal function and a lower incidence of IF/TA versus @entity9472 , and with similar rates of serious @entity281 and no @entity1071 .

title: Evaluation of the effect of XXXX exposure on outcomes in kidney transplant @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['interstitial fibrosis']

entities_list: @entity1071 :: ('MESH:D008232', 'Disease') :: ['Posttransplant lymphoproliferative disorder', 'PTLD']

entities_list: @entity16826 :: ('MESH:C479163', 'Chemical') :: ['Tofacitinib']

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'Serious infections']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['tubular atrophy']

answer: @entity16826 :: (MESH:C479163,Chemical) :: ['tofacitinib']


abstract: @entity16826 fixed-dose regimens attained better kidney function and comparable efficacy to @entity205 ( @entity9472 ) in kidney transplant @entity1 , albeit with increased risks of certain adverse events. This post-hoc analysis evaluated whether a @entity1 subgroup with an acceptable risk-benefit profile could be identified. @entity16826 exposure was a statistically significant predictor of serious @entity281 rate. One-hundred and eighty six kidney transplant @entity1 were re-categorized to above-median (AME) or below-median (BME) exposure groups. The 6-month biopsy-proven acute rejection rates in AME, BME and @entity9472 groups were 7.8%, 15.7% and 17.7%, respectively. Measured glomerular filtration rate was higher in AME and BME groups versus @entity9472 (61.2 and 67.9 vs. 53.9   mL/min) at Month 12. Fewer @entity1 developed @entity82 and @entity194 (IF/TA) at Month 12 in AME (20.5%) and BME (27.8%) groups versus @entity9472 (48.3%). @entity281 occurred more frequently in the AME group (53.0%) than in BME (28.4%) or @entity9472 (25.5%) groups. @entity1071 ( @entity1071 ) only occurred in the AME group. In kidney transplant @entity1 , the BME group preserved the clinical advantage of comparable acute rejection rates, improved renal function and a lower incidence of IF/TA versus @entity9472 , and with similar rates of serious @entity281 and no @entity1071 .

title: Evaluation of the effect of @entity16826 exposure on outcomes in kidney transplant XXXX .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: The objective of this study was to determine the mechanism by which activation of peroxisome proliferator-activated receptor-y promotes apoptosis of acinar cells in @entity788 . METHODS: AR42j cells pretreated with the peroxisome proliferator-activated receptor-y agonist @entity12098 were activated by @entity8629 as an in vitro model of acute @entity788 . Inflammatory cytokines and amylase were detected by enzyme-linked immunosorbent assay. Cell viability was determined by @entity2454 assay. Cell apoptosis was measured by flow cytometry and terminal deoxynucleotidyl transferase-mediated @entity1977 nick end labeling staining. Activity of caspases was determined. @entity2310 and @entity1976 levels were assayed by Western blot. RESULTS: Cytokines, amylase, and cellular proliferation decreased in @entity12098 -pretreated cells. @entity12098 increased the activity of caspases 3, 8, and 9 in @entity8629 -activated AR42j cells as well as in the pancreas of @entity35 3 hours after induction of severe acute @entity788 . Acinar cell apoptosis was induced by reducing the mitochondrial membrane potential in the @entity12098 group. @entity12098 increased expression of proapoptotic @entity2310 proteins and decreased antiapoptotic @entity1976 in @entity8629 -induced AR42j cells and decreased @entity1976 levels in pancreatic tissue of severe acute @entity788 @entity35 1 and 3 hours after induction. CONCLUSION: @entity12098 may promote apoptosis of acinar cells through both intrinsic and extrinsic apoptotic pathways in acute @entity788 .

title: Apoptotic Mechanisms of Peroxisome Proliferator-Activated Receptor-y Activation in Acinar Cells During Acute XXXX .

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']

entities_list: @entity12098 :: ('MESH:C060836', 'Chemical') :: ['pioglitazone', 'Pioglitazone']

entities_list: @entity2454 :: ('MESH:C022616', 'Chemical') :: ['3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide']

entities_list: @entity8629 :: ('MESH:D002108', 'Chemical') :: ['cerulein']

answer: @entity788 :: (MESH:D010190,Disease) :: ['Pancreatitis']


abstract: In a group of 1319 @entity1 with @entity583 treated in an intensive care unit from 1969-1977 30% died within the years 1969-1971 during the stay in the clinic. The hospital death-rate decreased significantly to 22% between the years 1975-1977, while the average age of the @entity1 was increasing, inspite of an increase in haemodynamically complicated @entity1188 . The number of @entity1 in the age group of 50-69 years has decreased from 56% to 41%. The number of @entity1 aged 70 years and older increased, while lethality decreased from 53% to 32%. Lethality in @entity1 with total AV-block decreased, and was unchanged in @entity1 with @entity616 . The incidence of @entity2224 increased, lethality in these @entity1 decreased. The high lethality of @entity1 with @entity1455 remained unchangedly high. In @entity1 with all other forms of severe @entity712 lethality decreased, even in @entity1 aged 80 years and more. @entity204 occurred later during 1975-1977 compared to former periods. The interval between the beginning of symptoms and admission to the intensive care unit decreased, but has no more any prognostic significance. Improved survival is referred to effective treatment of life threatening @entity299 and of severe @entity712 .

title: [Advances in the therapy of XXXX . Prognosis and clinical course of acute @entity583 with intensive therapy].

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['disorders of cardiac rhythm']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['acute myocardial infarction']

entities_list: @entity1455 :: ('MESH:D012770', 'Disease') :: ['cardiogenic shock']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['plurifascicular blocks']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarct']


abstract: In a group of 1319 @entity1 with @entity583 treated in an intensive care unit from 1969-1977 30% died within the years 1969-1971 during the stay in the clinic. The hospital death-rate decreased significantly to 22% between the years 1975-1977, while the average age of the @entity1 was increasing, inspite of an increase in haemodynamically complicated @entity1188 . The number of @entity1 in the age group of 50-69 years has decreased from 56% to 41%. The number of @entity1 aged 70 years and older increased, while lethality decreased from 53% to 32%. Lethality in @entity1 with total AV-block decreased, and was unchanged in @entity1 with @entity616 . The incidence of @entity2224 increased, lethality in these @entity1 decreased. The high lethality of @entity1 with @entity1455 remained unchangedly high. In @entity1 with all other forms of severe @entity712 lethality decreased, even in @entity1 aged 80 years and more. @entity204 occurred later during 1975-1977 compared to former periods. The interval between the beginning of symptoms and admission to the intensive care unit decreased, but has no more any prognostic significance. Improved survival is referred to effective treatment of life threatening @entity299 and of severe @entity712 .

title: [Advances in the therapy of @entity583 . Prognosis and clinical course of acute XXXX with intensive therapy].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial infarct']


abstract: OBJECTIVES: @entity957 ( @entity957 ) is an aggressive disease in the head and neck region. Therefore, simple and useful prognostic predictors of @entity957 are needed for clinical practice. This study investigates the prognostic significance of preoperative neutrophil-to-lymphocyte ratio (NLR) in @entity1 with @entity957 who received radical resections. METHODS: Retrospective review was conducted on medical records at a tertiary referral hospital involving 146 consecutive @entity1 who underwent radical resection for @entity957 between January 2000 and December 2010. The prognostic significance of NLR and other clinicopathologic factors was analyzed. The relationships between the NLR value and clinicopathologic factors were also evaluated. RESULTS: The study cohort consisted of 146 @entity1 with @entity957 , with a mean age of 57.5 years (range, 34-89 years). The median number of NLR was 2.28 (range, 0.71-8.75). On the basis of this median value, the cutoff value of NLR was set as 2.3. The @entity1 were divided into 2 groups: a low (<2.3) NLR group and a high (>= 2.3) NLR group. @entity1 with NLR of 2.3 or more had significantly higher incidence of wound complications (P = 0.026). The 3-year overall survival rate was 69.9% in @entity1 in the low NLR group and 27.4% in those in the high NLR group (P <0.001; hazard ratio;2.99; 95% confidence interval, 1.91-4.67). CONCLUSIONS: Results showed that high preoperative NLR is associated with @entity455 and poor survival in @entity1 with @entity957 .

title: Preoperative Neutrophil-to-Lymphocyte Ratio as Prognostic Predictor for XXXX after Radical Resections.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['HPSCC', 'Hypopharyngeal squamous cell carcinoma']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['increased wound complications']

answer: @entity957 :: (MESH:D002294,Disease) :: ['Hypopharyngeal Squamous Cell Carcinoma']


abstract: We describe a 54-year-old @entity1 who presented with right @entity158 . @entity1214 had been prescribed to treat @entity111 , and the symptoms resolved. Subsequently, the @entity1 consulted a local physician because of right @entity158 . Giant folds were found in the greater curvature of the gastric body, and he was referred to the Department of Gastroenterology, Kitasato University East Hospital. Upper gastrointestinal endoscopy revealed markedly enlarged folds in the greater curvature of the stomach, with redness and @entity4 mucosa in the lesser curvature. Biopsy showed marked @entity32 (mainly eosinophils), but no atypical cells. Blood tests showed marked @entity1712 and elevated immunoglobulin E levels in the serum. The results of various allergic examinations were negative, but the clinical course suggested drug-induced @entity14761 , and treatment was started. @entity1214 was withdrawn without adequate resolution of symptoms. Because the leukocyte and eosinophil counts continued to increase, the @entity1 was given suplatast, an anti-allergic agent. The symptoms and hematological values improved promptly. The @entity1 recovered uneventfully, with no recurrence.

title: XXXX associated with giant folds.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory cell infiltration']

entities_list: @entity1712 :: ('MESH:D004802', 'Disease') :: ['eosinophilia']

entities_list: @entity1214 :: ('MESH:D008911', 'Chemical') :: ['Minocycline']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['edematous']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['subcostal pain']

entities_list: @entity14761 :: ('MESH:C535952', 'Disease') :: ['eosinophilic gastroenteritis']

answer: @entity14761 :: (MESH:C535952,Disease) :: ['Eosinophilic gastroenteritis']


abstract: BACKGROUND: Personality determinants are an important predicator of @entity146 in drivers. The main objective of the study was to determine the relationship between @entity1314 ( @entity663 , extraversion, level of @entity148 ) and distinguishable risky behaviors of drivers of medical transport vehicles. MATERIAL AND METHODS: The study covered 106 male drivers from the Wielkopolskie Voivodeship, working in health care, having a license to drive emergency vehicles. To achieve the research objectives a questionnaire was developed and applied. It concerned risky @entity146 among drivers of medical transport. The personality suitability was determined using the questionnaire methods on self-assessment: Polish versions of Eysenck Personality Questionnaire - Revised (EPQ-R) and the State-Trait @entity148 Inventory (STAI) questionnaire. RESULTS: It was shown that drivers with introverted characteristics declare driving vehicles of reduced technical efficiency more often than extroverts. The level of the @entity148 as a trait A-characteristic affects the display of distracting behaviors, making decisions about driving a vehicle that is inefficient, driving in a bad psychophysical condition, as well as maintaining too small distance from the preceding vehicle. The higher the intensity of @entity148 characteristics, the higher the intensity of given behaviors. CONCLUSIONS: Based on the study results, it can be assumed that there is a relationship between determinants of personality and the display of risky behaviors of drivers of medical transport vehicles. Thus it can be concluded that the level of extraversion and @entity148 as a trait are the differentiating characteristics of respondents.

title: [Determinants of personality and risky XXXX at work in drivers of medical transport vehicles in the Wielkopolska (Greater Poland) voivodeship].

entities_list: @entity1314 :: ('MESH:D010554', 'Disease') :: ['personality determinants']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety', 'anxiety - features']

entities_list: @entity663 :: ('MESH:C564323', 'Disease') :: ['neuroticism']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['road behaviors']

answer: @entity146 :: (MESH:D001523,Disease) :: ['road behaviors']


abstract: It is well known that biological tissues adapt their properties because of different mechanical and chemical stimuli. The goal of this work is to study the collagen turnover in the arterial tissue of @entity101 @entity1 through a coupled computational mechano-chemical model. Although it has been widely studied experimentally, computational models dealing with the mechano-chemical approach are not. The present approach can be extended easily to study other aspects of bone remodeling or collagen degradation in @entity299 . The model can be divided into three different stages. First, we study the smooth muscle cell synthesis of different biological substances due to over-stretching during @entity101 . Next, we study the mass-transport of these substances along the arterial wall. The last step is to compute the turnover of collagen based on the amount of these substances in the arterial wall which interact with each other to modify the turnover rate of collagen. We simulate this process in a finite element model of a real @entity1 carotid artery. The final results show the well-known stiffening of the arterial wall due to the increase in the collagen content.

title: Computational model of collagen turnover in carotid arteries during XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart diseases']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: BACKGROUND: American @entity4536 (ACL) is a re-emerging disease in the state of S  o Paulo, Brazil. It is important to understand both the vector and disease distribution to help design control strategies. As an initial step in applying geographic information systems (GIS) and remote sensing (RS) tools to map disease-risk, the objectives of the present work were to: (i) produce a single database of species distributions of the sand @entity238 vectors in the state of S  o Paulo, (ii) create combined distributional maps of both the incidence of ACL and its sand @entity238 vectors, and (iii) thereby provide individual municipalities with a source of reference material for work carried out in their area. RESULTS: A database containing 910 individual records of sand @entity238 occurrence in the state of S  o Paulo, from 37 different sources, was compiled. These records date from between 1943 to 2009, and describe the presence of at least one of the six incriminated or suspected sand @entity238 vector species in 183/645 (28.4%) municipalities. For the remaining 462 (71.6%) municipalities, we were unable to locate records of any of the six incriminated or suspected sand @entity238 vector species (Nyssomyia intermedia, N. neivai, N. whitmani, Pintomyia fischeri, P. pessoai and Migonemyia migonei). The distribution of each of the six incriminated or suspected vector species of ACL in the state of S  o Paulo were individually mapped and overlaid on the incidence of ACL for the period 1993 to 1995 and 1998 to 2007. Overall, the maps reveal that the six sand @entity238 vector species analyzed have unique and heterogeneous, although often overlapping, distributions. Several sand @entity238 species - Nyssomyia intermedia and N. neivai - are highly localized, while the other sand @entity238 species - N. whitmani, M. migonei, @entity7866 and P. pessoai - are much more broadly distributed. ACL has been reported in 160/183 (87.4%) of the municipalities with records for at least one of the six incriminated or suspected sand @entity238 vector species, while there are no records of any of these sand @entity238 species in 318/478 (66.5%) municipalities with ACL. CONCLUSIONS: The maps produced in this work provide basic data on the distribution of the six incriminated or suspected sand @entity238 vectors of ACL in the state of S  o Paulo, and highlight the complex and geographically heterogeneous pattern of ACL transmission in the region. Further studies are required to clarify the role of each of the six suspected sand @entity238 vector species in different regions of the state of S  o Paulo, especially in the majority of municipalities where ACL is present but sand @entity238 vectors have not yet been identified.

title: Geographical distribution of American XXXX and its phlebotomine vectors (Diptera: Psychodidae) in the state of S  o Paulo, Brazil.

entities_list: @entity4536 :: ('MESH:D016773', 'Disease') :: ['cutaneous leishmaniasis']

answer: @entity4536 :: (MESH:D016773,Disease) :: ['cutaneous leishmaniasis']


abstract: BACKGROUND: The aim of this study was to develop and validate an automated method for extracting forward @entity64 volume ( @entity21829 ) using indicator dilution theory directly from dynamic positron emission tomography (PET) studies for two different tracers and scanners. METHODS: 35 subjects underwent a dynamic @entity18808 PET scan on a Siemens Biograph TruePoint-64 PET/CT (scanner I). In addition, 10 subjects underwent both dynamic @entity8493 -water PET and @entity18808 PET scans on a GE Discovery-ST PET/CT (scanner II). The left ventricular (LV)-aortic time-activity curve (TAC) was extracted automatically from PET data using cluster analysis. The first-pass peak was isolated by automatic extrapolation of the downslope of the TAC. @entity21829 was calculated as the injected dose divided by the product of heart rate and the area under the curve of the first-pass peak. Gold standard @entity21829 was measured using phase-contrast cardiovascular magnetic resonance (CMR). RESULTS: FSVPET correlated highly with FSVCMR (r   =   0.87, slope   =   0.90 for scanner I, r   =   0.87, slope   =   1.65, and r   =   0.85, slope   =   1.69 for scanner II for @entity8493 -water and @entity18808 , respectively) although a systematic bias was observed for both scanners (p   <   0.001 for all). @entity21829 based on @entity18808 and @entity8493 -water correlated highly (r   =   0.99, slope   =   1.03) with no significant difference between @entity21829 estimates (p   =   0.14). CONCLUSIONS: @entity21829 can be obtained automatically using dynamic PET/CT and cluster analysis. Results are almost identical for @entity18808 and @entity8493 -water. A scanner-dependent bias was observed, and a scanner calibration factor is required for multi-scanner studies. Generalization of the method to other tracers and scanners requires further validation.

title: Automatic extraction of forward XXXX volume using dynamic PET/CT: a dual-tracer and dual-scanner validation in patients with heart valve disease.

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: OBJECTIVE: There are limited data concerning the evolution of radiation-induced @entity4614 in adult-onset @entity1313 (AO-BT) survivors; in part the consequence of the limited survival of many of these individuals. We aim to characterise the pituitary-related outcomes following cranial radiotherapy (cXRT) for adult-onset primary @entity1313 . DESIGN: We retrospectively analyzed longitudinal data of @entity1 with AO-BT who received cXRT within a tertiary @entity5 referral center. @entity1 : 107 adults (age 40.0  13.1 years) followed for a median duration of eight years following cXRT. MEASUREMENTS: Prevalence of radiotherapy-induced @entity4614 . RESULTS: 94.4% received fractionated photon radiotherapy (median dose 54Gy), while the remaining @entity1 received proton beam or stereotactic radiotherapy. 88.8% of @entity1 developed @entity4614 during follow-up. The frequency of GH, gonadotropin, ACTH and @entity1220 was 86.9% (severe GHD 64.5%, partial GHD 22.4%), 34.6%, 23.4% and 11.2% respectively. @entity16054 was clinically significant, necessitating glucocorticoid replacement, in only 10.3% of cases. @entity4089 developed in 15% of @entity1 , which was persistent in only 50% of cases. @entity7961 were present in 47.7% of @entity1 ; encountered more frequently in @entity1 with @entity5 in proximity to the sella. Longitudinal data analysis revealed @entity51 throughout the follow-up period, with incidence of all @entity7961 almost doubling between years 2 and 7 of follow-up. CONCLUSIONS: @entity4611 in AO-BT survivors following cXRT is a common, evolving, time-dependent phenomenon. It is important deficits are identified early and replacement therapies introduced to optimize quality of life in these individuals, where prognosis is often guarded. This article is protected by copyright. All rights reserved.

title: @entity4611 following cranial radiotherapy for adult-onset XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity4089 :: ('MESH:D006966', 'Disease') :: ['Hyperprolactinaemia']

entities_list: @entity1220 :: ('MESH:D006964', 'Disease') :: ['TSH deficiencies']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['brain tumour', 'non-pituitary brain tumours']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours']

entities_list: @entity16054 :: ('MESH:C562707', 'Disease') :: ['ACTH deficiency']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['accumulation of hormone deficits']

entities_list: @entity4614 :: ('MESH:D007018', 'Disease') :: ['hypopituitarism']

entities_list: @entity4611 :: ('MESH:D010900', 'Disease') :: ['Pituitary dysfunction']

entities_list: @entity7961 :: ('MESH:C580003', 'Disease') :: ['pituitary hormone deficiencies', 'Multiple pituitary hormone deficiencies']

answer: @entity1313 :: (MESH:D001932,Disease) :: ['non-pituitary brain tumours']


abstract: OBJECTIVE: There are limited data concerning the evolution of radiation-induced @entity4614 in adult-onset @entity1313 (AO-BT) survivors; in part the consequence of the limited survival of many of these individuals. We aim to characterise the pituitary-related outcomes following cranial radiotherapy (cXRT) for adult-onset primary @entity1313 . DESIGN: We retrospectively analyzed longitudinal data of @entity1 with AO-BT who received cXRT within a tertiary @entity5 referral center. @entity1 : 107 adults (age 40.0  13.1 years) followed for a median duration of eight years following cXRT. MEASUREMENTS: Prevalence of radiotherapy-induced @entity4614 . RESULTS: 94.4% received fractionated photon radiotherapy (median dose 54Gy), while the remaining @entity1 received proton beam or stereotactic radiotherapy. 88.8% of @entity1 developed @entity4614 during follow-up. The frequency of GH, gonadotropin, ACTH and @entity1220 was 86.9% (severe GHD 64.5%, partial GHD 22.4%), 34.6%, 23.4% and 11.2% respectively. @entity16054 was clinically significant, necessitating glucocorticoid replacement, in only 10.3% of cases. @entity4089 developed in 15% of @entity1 , which was persistent in only 50% of cases. @entity7961 were present in 47.7% of @entity1 ; encountered more frequently in @entity1 with @entity5 in proximity to the sella. Longitudinal data analysis revealed @entity51 throughout the follow-up period, with incidence of all @entity7961 almost doubling between years 2 and 7 of follow-up. CONCLUSIONS: @entity4611 in AO-BT survivors following cXRT is a common, evolving, time-dependent phenomenon. It is important deficits are identified early and replacement therapies introduced to optimize quality of life in these individuals, where prognosis is often guarded. This article is protected by copyright. All rights reserved.

title: XXXX following cranial radiotherapy for adult-onset @entity1313 .

answer: @entity4611 :: (MESH:D010900,Disease) :: ['Pituitary dysfunction']


abstract: Importance: @entity1028 are associated with @entity32 within the aortic wall, and previous studies have suggested that @entity32 may be a consequence of a dysregulated and persistent autoimmune response. Persistent aortic remodeling after @entity439 repair could place the @entity1 at risk for endoleak or sac rupture. Objective: To determine whether @entity1 with systemic @entity32 and large @entity439 have persistent aortic remodeling after @entity439 repair (EVAR). Design, Setting, and @entity1 : The records of all @entity1 who underwent EVAR between July 2002 and June 2011 at the Veterans Affairs Connecticut Healthcare System were included in this retrospective review. @entity1 were considered to have a systemic @entity32 when confirmed by a referring specialist. Post-EVAR surveillance was performed by yearly imaging. Intervention: @entity439 repair. Main Outcomes and Measures: Significant endoleak, defined as endoleak and sac diameter increase of 0.5 cm or greater. Results: A total of 51 of 79 @entity1 (65%) had a systemic @entity32 . These @entity1 had similar comorbid conditions compared with @entity1 without @entity32 but significantly greater numbers of major @entity260 after EVAR (23.5% vs 3.6%; P   =   .02) and @entity260 after EVAR (27.5% vs 7.1%; P   =   .03). @entity1 with a history of systemic @entity32 developed more @entity1070 (45.1% vs 17.9%; P   =   .02) and late sac expansion (51.0% vs 21.4%; P   =   .01) and required more interventions (21.6% vs 3.6%; P   =   .03) during long-term follow-up. Systemic @entity32 was significantly associated with significant endoleak (odds ratio, 5.18; 95% CI, 1.56-17.16; P   =   .007). Conclusions and Relevance: @entity1 with systemic @entity32 are at high risk for @entity260 , @entity1070 , sac expansion, and additional interventions after EVAR. Additional strategies for improving the efficacy of EVAR in these @entity1 may be warranted.

title: @entity32 and Its Association With @entity1070 and Late Interventions After XXXX Repair.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'Participants']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['chronic inflammation', 'inflammation', 'inflammatory disease']

entities_list: @entity1070 :: ('MESH:D057867', 'Disease') :: ['endoleaks', 'type II endoleak']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['overall postoperative complications', 'postoperative complications']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['endovascular aneurysm', 'aneurysms', 'aneurysm', 'Endovascular aneurysm']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['Abdominal aortic aneurysms']

answer: @entity439 :: (MESH:D000783,Disease) :: ['Endovascular Aneurysm']


abstract: Importance: @entity1028 are associated with @entity32 within the aortic wall, and previous studies have suggested that @entity32 may be a consequence of a dysregulated and persistent autoimmune response. Persistent aortic remodeling after @entity439 repair could place the @entity1 at risk for endoleak or sac rupture. Objective: To determine whether @entity1 with systemic @entity32 and large @entity439 have persistent aortic remodeling after @entity439 repair (EVAR). Design, Setting, and @entity1 : The records of all @entity1 who underwent EVAR between July 2002 and June 2011 at the Veterans Affairs Connecticut Healthcare System were included in this retrospective review. @entity1 were considered to have a systemic @entity32 when confirmed by a referring specialist. Post-EVAR surveillance was performed by yearly imaging. Intervention: @entity439 repair. Main Outcomes and Measures: Significant endoleak, defined as endoleak and sac diameter increase of 0.5 cm or greater. Results: A total of 51 of 79 @entity1 (65%) had a systemic @entity32 . These @entity1 had similar comorbid conditions compared with @entity1 without @entity32 but significantly greater numbers of major @entity260 after EVAR (23.5% vs 3.6%; P   =   .02) and @entity260 after EVAR (27.5% vs 7.1%; P   =   .03). @entity1 with a history of systemic @entity32 developed more @entity1070 (45.1% vs 17.9%; P   =   .02) and late sac expansion (51.0% vs 21.4%; P   =   .01) and required more interventions (21.6% vs 3.6%; P   =   .03) during long-term follow-up. Systemic @entity32 was significantly associated with significant endoleak (odds ratio, 5.18; 95% CI, 1.56-17.16; P   =   .007). Conclusions and Relevance: @entity1 with systemic @entity32 are at high risk for @entity260 , @entity1070 , sac expansion, and additional interventions after EVAR. Additional strategies for improving the efficacy of EVAR in these @entity1 may be warranted.

title: @entity32 and Its Association With XXXX and Late Interventions After @entity439 Repair.

answer: @entity1070 :: (MESH:D057867,Disease) :: ['Type II Endoleak']


abstract: Importance: @entity1028 are associated with @entity32 within the aortic wall, and previous studies have suggested that @entity32 may be a consequence of a dysregulated and persistent autoimmune response. Persistent aortic remodeling after @entity439 repair could place the @entity1 at risk for endoleak or sac rupture. Objective: To determine whether @entity1 with systemic @entity32 and large @entity439 have persistent aortic remodeling after @entity439 repair (EVAR). Design, Setting, and @entity1 : The records of all @entity1 who underwent EVAR between July 2002 and June 2011 at the Veterans Affairs Connecticut Healthcare System were included in this retrospective review. @entity1 were considered to have a systemic @entity32 when confirmed by a referring specialist. Post-EVAR surveillance was performed by yearly imaging. Intervention: @entity439 repair. Main Outcomes and Measures: Significant endoleak, defined as endoleak and sac diameter increase of 0.5 cm or greater. Results: A total of 51 of 79 @entity1 (65%) had a systemic @entity32 . These @entity1 had similar comorbid conditions compared with @entity1 without @entity32 but significantly greater numbers of major @entity260 after EVAR (23.5% vs 3.6%; P   =   .02) and @entity260 after EVAR (27.5% vs 7.1%; P   =   .03). @entity1 with a history of systemic @entity32 developed more @entity1070 (45.1% vs 17.9%; P   =   .02) and late sac expansion (51.0% vs 21.4%; P   =   .01) and required more interventions (21.6% vs 3.6%; P   =   .03) during long-term follow-up. Systemic @entity32 was significantly associated with significant endoleak (odds ratio, 5.18; 95% CI, 1.56-17.16; P   =   .007). Conclusions and Relevance: @entity1 with systemic @entity32 are at high risk for @entity260 , @entity1070 , sac expansion, and additional interventions after EVAR. Additional strategies for improving the efficacy of EVAR in these @entity1 may be warranted.

title: XXXX and Its Association With @entity1070 and Late Interventions After @entity439 Repair.

answer: @entity32 :: (MESH:D007249,Disease) :: ['Systemic Inflammatory Disease']


abstract: PURPOSE: To evaluate the @entity5 -inducing ability of a few leukemic cells xenotransplanted inside an artificial ovary. METHODS: Ten and 100 @entity1 leukemic cells were embedded in a fibrin matrix along with 50,000 @entity1 ovarian stromal cells, and grafted to the peritoneal bursa of 5 and 5 @entity915 @entity19 respectively. Four @entity19 grafted with 3x10(6) leukemic cells in fibrin served as positive controls. At 20 weeks post-transplantation, the grafts, liver, spleen, blood and bone marrow were analyzed for the presence of @entity1778 by anti- @entity40261 IHC, flow cytometry (FC) and PCR. RESULTS: All @entity19 grafted with 3x10(6) cells developed peritoneal masses 4 weeks after xenotransplantation, and @entity262 was confirmed by IHC, PCR and FC. Among @entity19 grafted with 10 or 100 leukemic cells, none showed any sign of @entity1778 after 20 weeks, and IHC, FC and PCR on the different recovered tissues all proved negative. CONCLUSION: This study investigates the @entity5 -inducing potential of a few leukemic cells grafted inside an artificial ovary. Transplantation of 100 leukemic cells appears to be insufficient to induce @entity1778 after 20 weeks. These results in an @entity465 xenografting model are quite reassuring. However, for clinical application, follicle suspensions must be purged of leukemic cells before grafting, as even the slightest risk should be avoided.

title: Is transplantation of a few leukemic cells inside an artificial ovary able to induce XXXX in an experimental model?

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic disease']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficient']

answer: @entity1778 :: (MESH:D007938,Disease) :: ['leukemia']


abstract: BACKGROUND: Shoulder @entity158 is a common musculoskeletal symptom with a wide range of potential causes; however, the majority of conditions can be managed with conservative treatment. The aim of this study is to assess the efficacy and safety of Traumeel injections versus @entity228 injections and placebo in the treatment of @entity717 and @entity2585 and expand the current evidence base for the conservative treatment of @entity717 . METHODS/DESIGN: This is a multi-center, randomized, double-blind, 16-week, three-arm, parallel-group, active- and placebo-controlled trial to assess the efficacy and safety of Traumeel 2 ml injection versus @entity619 8 mg injection versus placebo (saline solution). @entity1 will be randomly allocated to Traumeel, @entity619 or placebo in a 2:2:1 randomization. After 1 week screening, @entity1 will receive 3 injections at weekly intervals (days 1, 8 and 15) with additional follow-up assessments on day 22, a telephone consultation in week 9 and a final visit at week 15. Male and female @entity1 aged 40 to 65 years, inclusive, will be recruited if they have acute episodes of @entity717 and/or @entity2585 . @entity1 with @entity730 in the shoulder joint or a complete rotator cuff tear will be excluded. At least 160 @entity1 will be recruited. All subacromial injections will be performed under ultrasound guidance utilizing a common technique. The only rescue medication permitted will be @entity1443 ( @entity1443 ), with usage recorded. The primary endpoint is change from baseline in abduction-rotation @entity158 visual analog scale (0-100 mm scale, 0 corresponds to no @entity158 and 100 to extreme @entity158 ) at day 22 (Traumeel injections versus @entity619 injections) for active external rotation. Secondary efficacy parameters include @entity11535 , disability of arm, shoulder, hand score and @entity1 's/investigator's global assessment. Clinical efficacy will be assessed as non-inferiority of Traumeel with respect to @entity619 regarding the primary efficacy parameter. DISCUSSION: It is hoped that the results of this trial will expand the treatment options and evidence base available for the management of rotator cuff disease. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01702233 . EudraCT number: 2012-003393-12.

title: A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs XXXX injection in @entity717 : the TRAumeel in @entity717 (TRARO) study protocol.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcifications']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity11535 :: ('MESH:D009041', 'Disease') :: ['range of motion']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['rotator cuff syndrome', 'chronic rotator cuff syndrome']

entities_list: @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol', 'acetaminophen']

answer: @entity619 :: (MESH:D003907,Chemical) :: ['dexamethasone']


abstract: BACKGROUND: Shoulder @entity158 is a common musculoskeletal symptom with a wide range of potential causes; however, the majority of conditions can be managed with conservative treatment. The aim of this study is to assess the efficacy and safety of Traumeel injections versus @entity228 injections and placebo in the treatment of @entity717 and @entity2585 and expand the current evidence base for the conservative treatment of @entity717 . METHODS/DESIGN: This is a multi-center, randomized, double-blind, 16-week, three-arm, parallel-group, active- and placebo-controlled trial to assess the efficacy and safety of Traumeel 2 ml injection versus @entity619 8 mg injection versus placebo (saline solution). @entity1 will be randomly allocated to Traumeel, @entity619 or placebo in a 2:2:1 randomization. After 1 week screening, @entity1 will receive 3 injections at weekly intervals (days 1, 8 and 15) with additional follow-up assessments on day 22, a telephone consultation in week 9 and a final visit at week 15. Male and female @entity1 aged 40 to 65 years, inclusive, will be recruited if they have acute episodes of @entity717 and/or @entity2585 . @entity1 with @entity730 in the shoulder joint or a complete rotator cuff tear will be excluded. At least 160 @entity1 will be recruited. All subacromial injections will be performed under ultrasound guidance utilizing a common technique. The only rescue medication permitted will be @entity1443 ( @entity1443 ), with usage recorded. The primary endpoint is change from baseline in abduction-rotation @entity158 visual analog scale (0-100 mm scale, 0 corresponds to no @entity158 and 100 to extreme @entity158 ) at day 22 (Traumeel injections versus @entity619 injections) for active external rotation. Secondary efficacy parameters include @entity11535 , disability of arm, shoulder, hand score and @entity1 's/investigator's global assessment. Clinical efficacy will be assessed as non-inferiority of Traumeel with respect to @entity619 regarding the primary efficacy parameter. DISCUSSION: It is hoped that the results of this trial will expand the treatment options and evidence base available for the management of rotator cuff disease. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01702233 . EudraCT number: 2012-003393-12.

title: A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs @entity619 injection in XXXX : the TRAumeel in @entity717 (TRARO) study protocol.

answer: @entity717 :: (MESH:D009069,Disease) :: ['rotator cuff syndrome']


abstract: BACKGROUND: Shoulder @entity158 is a common musculoskeletal symptom with a wide range of potential causes; however, the majority of conditions can be managed with conservative treatment. The aim of this study is to assess the efficacy and safety of Traumeel injections versus @entity228 injections and placebo in the treatment of @entity717 and @entity2585 and expand the current evidence base for the conservative treatment of @entity717 . METHODS/DESIGN: This is a multi-center, randomized, double-blind, 16-week, three-arm, parallel-group, active- and placebo-controlled trial to assess the efficacy and safety of Traumeel 2 ml injection versus @entity619 8 mg injection versus placebo (saline solution). @entity1 will be randomly allocated to Traumeel, @entity619 or placebo in a 2:2:1 randomization. After 1 week screening, @entity1 will receive 3 injections at weekly intervals (days 1, 8 and 15) with additional follow-up assessments on day 22, a telephone consultation in week 9 and a final visit at week 15. Male and female @entity1 aged 40 to 65 years, inclusive, will be recruited if they have acute episodes of @entity717 and/or @entity2585 . @entity1 with @entity730 in the shoulder joint or a complete rotator cuff tear will be excluded. At least 160 @entity1 will be recruited. All subacromial injections will be performed under ultrasound guidance utilizing a common technique. The only rescue medication permitted will be @entity1443 ( @entity1443 ), with usage recorded. The primary endpoint is change from baseline in abduction-rotation @entity158 visual analog scale (0-100 mm scale, 0 corresponds to no @entity158 and 100 to extreme @entity158 ) at day 22 (Traumeel injections versus @entity619 injections) for active external rotation. Secondary efficacy parameters include @entity11535 , disability of arm, shoulder, hand score and @entity1 's/investigator's global assessment. Clinical efficacy will be assessed as non-inferiority of Traumeel with respect to @entity619 regarding the primary efficacy parameter. DISCUSSION: It is hoped that the results of this trial will expand the treatment options and evidence base available for the management of rotator cuff disease. TRIAL REGISTRATION: ClinicalTrials.gov: NCT01702233 . EudraCT number: 2012-003393-12.

title: A multi-center, double-blind, randomized, placebo-controlled trial protocol to assess Traumeel injection vs @entity619 injection in @entity717 : the TRAumeel in XXXX (TRARO) study protocol.

answer: @entity717 :: (MESH:D009069,Disease) :: ['ROtator cuff syndrome']


abstract: INTRODUCTION AND OBJECTIVES: The @entity219 -finger transcription factor Kr  ppel-like factor 2 (KLF2) transduces blood flow into molecular signals responsible for a wide range of responses within the vasculature. KLF2 maintains a healthy, quiescent endothelial phenotype. Previous studies report a range of phenotypes following morpholino antisense oligonucleotide-induced @entity71890 knockdown in @entity3392 . Targeted genome editing is an increasingly applied method for functional assessment of candidate genes. We therefore generated a stable @entity71890 mutant @entity3392 and characterised its cardiovascular and haematopoietic development. METHODS AND RESULTS: Using Transcription Activator-Like Effector Nucleases (TALEN) we generated a @entity71890 mutant (klf2ash317) with a 14bp deletion leading to a premature stop codon in exon 2. Western blotting confirmed loss of wild type @entity71890 protein and the presence of a truncated protein in klf2ash317 mutants. Homozygous klf2ash317 mutants exhibit no defects in vascular patterning, survive to adulthood and are fertile, without displaying previously described morphant phenotypes such as high-output @entity712 , reduced haematopoetic stem cell (HSC) development or impaired formation of the 5th accessory aortic arch. Homozygous klf2ash317 mutation did not reduce angiogenesis in @entity3392 with homozygous mutations in @entity280 ( @entity280 ), a form of angiogenesis that is dependent on blood flow. We examined expression of three klf family members in wildtype and klf2ash317 @entity3392 . We detected vascular expression of @entity71891 (but not @entity71892 or @entity71893 / @entity71893 / @entity71893 ) in wildtypes but found no differences in expression that might account for the lack of phenotype in klf2ash317 mutants. @entity71891 morpholino knockdown did not affect heart rate or impair formation of the 5th accessory aortic arch in either wildtypes or klf2ash317 mutants. CONCLUSIONS: The klf2ash317 mutation produces a truncated @entity71890 protein but, unlike morpholino induced @entity71890 knockdown, does not affect cardiovascular development.

title: klf2ash317 Mutant XXXX Do Not Recapitulate Morpholino-Induced Vascular and Haematopoietic Phenotypes.

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure']

entities_list: @entity280 :: ('MESH:D006623', 'Disease') :: ['vhl', 'von Hippel Lindau']

answer: @entity3392 :: (7955,Species) :: ['Zebrafish']


abstract: UNASSIGNED: @entity2885 ( @entity2885 ) is a life-threatening @entity8 caused by gas-producing bacteria and fungi. It usually occurs in @entity1 with @entity6 and @entity1 with @entity5450 . A combination of systemic antibiotics, percutaneous catheter drainage, or open nephrectomy is typically required to achieve cure. Because of grim prognosis, resorting to interventional methods is frequently inevitable. We report the case of a 77-year-old @entity1 with @entity6 and @entity454 on chronic hemodialysis that presented with @entity221 and @entity812 . A bubbly gas pattern inside the left kidney was demonstrated on abdominal computed tomography scan and blood cultures grew @entity526 . She was successfully treated solely with systemic antibiotics. This highlights the fact that prompt recognition of imaging findings associated with benign prognosis is essential for a favorable outcome. It allows for an effective management avoiding high-risk interventions, especially in frail @entity1 with multiple comorbidities. Finally, we review all published cases of @entity2885 in chronic dialysis @entity1 .

title: Successful medical treatment of XXXX in chronic hemodialysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal infection']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity812 :: ('MESH:D021501', 'Disease') :: ['left flank pain']

entities_list: @entity5450 :: ('MESH:D014570', 'Disease') :: ['urinary tract obstruction']

entities_list: @entity2885 :: ('MESH:D011704', 'Disease') :: ['Emphysematous pyelonephritis', 'EPN']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']

answer: @entity2885 :: (MESH:D011704,Disease) :: ['emphysematous pyelonephritis']


abstract: INTRODUCTION: @entity0 is heterogeneous, with different responses to NC even within similar histology and stages. OBJECTIVE: To evaluate clinical/pathological response to NC according to different @entity5 subtypes in Mexican @entity0 @entity1 . @entity1 AND METHODS: Retrospective study of @entity1 with @entity0 stages II-III, and complete immunohistochemistry (IHC), such as hormonal receptors @entity1722 and Ki67, treated with NC and surgery. Descriptive and comparative analyses between different intrinsic subtypes were performed. RESULTS: A total of 117 @entity1 were included with 48.6    10.6 years of age, stage II (24%), and III (76%). We identified 20 (17.1%) cases of luminal A, 37 (31.6%) luminal B @entity1722 -, 13 (11.1%) luminal B @entity1722 +, 12 (10.3%) @entity1722 +, and 35 (29.9%) triple negative. Clinical complete response ( @entity5 and lymph nodes) in luminal A was 10%, in luminal B @entity1722 - 10.8%, luminal B @entity1722 + 15.4%, @entity1722 + 25%, and in triple negative 14.3%. Conservative surgeries were done in 9 (7.7%) @entity1 . There is a weak positive association between Ki67 expression and @entity5 clinical response. Pathological complete response occurred in 8 (6.83%) cases, being more frequent in luminal B @entity1722 + @entity1 (23%). CONCLUSIONS: Pathological complete responses were more often in luminal B @entity1722 + cases.

title: [Neoadjuvant Chemotherapy (NC) Response in @entity1 with XXXX According to Immunohistochemical Intrinsic Subtypes (IHC)].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['Breast cancer', 'breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast Cancer']


abstract: INTRODUCTION: @entity0 is heterogeneous, with different responses to NC even within similar histology and stages. OBJECTIVE: To evaluate clinical/pathological response to NC according to different @entity5 subtypes in Mexican @entity0 @entity1 . @entity1 AND METHODS: Retrospective study of @entity1 with @entity0 stages II-III, and complete immunohistochemistry (IHC), such as hormonal receptors @entity1722 and Ki67, treated with NC and surgery. Descriptive and comparative analyses between different intrinsic subtypes were performed. RESULTS: A total of 117 @entity1 were included with 48.6    10.6 years of age, stage II (24%), and III (76%). We identified 20 (17.1%) cases of luminal A, 37 (31.6%) luminal B @entity1722 -, 13 (11.1%) luminal B @entity1722 +, 12 (10.3%) @entity1722 +, and 35 (29.9%) triple negative. Clinical complete response ( @entity5 and lymph nodes) in luminal A was 10%, in luminal B @entity1722 - 10.8%, luminal B @entity1722 + 15.4%, @entity1722 + 25%, and in triple negative 14.3%. Conservative surgeries were done in 9 (7.7%) @entity1 . There is a weak positive association between Ki67 expression and @entity5 clinical response. Pathological complete response occurred in 8 (6.83%) cases, being more frequent in luminal B @entity1722 + @entity1 (23%). CONCLUSIONS: Pathological complete responses were more often in luminal B @entity1722 + cases.

title: [Neoadjuvant Chemotherapy (NC) Response in XXXX with @entity0 According to Immunohistochemical Intrinsic Subtypes (IHC)].

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVES/HYPOTHESIS: To determine the diagnostic value of @entity419 positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal @entity3 in @entity1 with @entity957 (SCC) with @entity135 and to assess the role of PET-CT as a supplement to CT/MR. STUDY DESIGN: Retrospective analysis. METHODS: A total of 39 @entity1 with @entity135 (36 @entity1 and 3 @entity1 ; average age 65.4 years) underwent @entity5 resection and neck dissection as primary treatment. All @entity1 were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. RESULTS: Twenty (51.3%) of the 39 @entity1 were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six @entity1 who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. CONCLUSIONS: The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal @entity3 in @entity1 with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

title: @entity419 PET-CT as a supplement to CT/MRI for detection of nodal XXXX in hypopharyngeal SCC with @entity135 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['palpably negative neck']

entities_list: @entity419 :: ('MESH:D019788', 'Chemical') :: ['(18) F-fluorodeoxyglucose']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['hypopharyngeal squamous cell carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastasis']


abstract: OBJECTIVES/HYPOTHESIS: To determine the diagnostic value of @entity419 positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal @entity3 in @entity1 with @entity957 (SCC) with @entity135 and to assess the role of PET-CT as a supplement to CT/MR. STUDY DESIGN: Retrospective analysis. METHODS: A total of 39 @entity1 with @entity135 (36 @entity1 and 3 @entity1 ; average age 65.4 years) underwent @entity5 resection and neck dissection as primary treatment. All @entity1 were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. RESULTS: Twenty (51.3%) of the 39 @entity1 were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six @entity1 who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. CONCLUSIONS: The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal @entity3 in @entity1 with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

title: XXXX PET-CT as a supplement to CT/MRI for detection of nodal @entity3 in hypopharyngeal SCC with @entity135 .

answer: @entity419 :: (MESH:D019788,Chemical) :: ['(18) F-FDG']


abstract: OBJECTIVES/HYPOTHESIS: To determine the diagnostic value of @entity419 positron emission tomography-computed tomography (PET-CT) compared with CT or magnetic resonance (MR) imaging for the detection of nodal @entity3 in @entity1 with @entity957 (SCC) with @entity135 and to assess the role of PET-CT as a supplement to CT/MR. STUDY DESIGN: Retrospective analysis. METHODS: A total of 39 @entity1 with @entity135 (36 @entity1 and 3 @entity1 ; average age 65.4 years) underwent @entity5 resection and neck dissection as primary treatment. All @entity1 were preoperatively evaluated with PET-CT and CT and/or MR, and imaging data were retrospectively reviewed. The diagnostic performance of PET-CT, CT/MR, and a combination of PET-CT and CT/MR was assessed using histopathologic results as a gold standard. RESULTS: Twenty (51.3%) of the 39 @entity1 were found to have neck metastases. On a level-based analysis, the sensitivity of PET-CT, CT/MR, and combined interpretation of PET-CT and CT/MR was 65.7%, 57.1%, and 65.7%, respectively, but without statistical significance. Of the six @entity1 who showed false negative neck findings based on CT/MR in addition to palpation, four cases were still missed with additional PET-CT. CONCLUSIONS: The addition of PET-CT examination to anatomic imaging involving CT and MR did not provide additional benefit for the preoperative evaluation of cervical nodal @entity3 in @entity1 with hypopharyngeal SCC with nonpalpable neck, yielding insufficient data to spare elective neck dissection. LEVEL OF EVIDENCE: 4. Laryngoscope, 2015.

title: @entity419 PET-CT as a supplement to CT/MRI for detection of nodal @entity3 in hypopharyngeal SCC with XXXX .

answer: @entity135 :: (MESH:D006258,Disease) :: ['palpably negative neck']


abstract: OBJECTIVE: Duplex ultrasonography (DUS) has been the mainstay for diagnosing @entity543 and is often the sole diagnostic modality used prior to intervention. Highly calcified plaque, however, results in an acoustic shadow (AcS) that obscures the vessel lumen and inhibits the sonographer's ability to obtain Doppler velocity measurements. It is unknown whether DUS can accurately determine the degree of @entity543 in these settings. METHODS: From July 2012 to December 2013, all @entity1 with AcS on DUS measuring >= 5  mm in the @entity2270 were cross-referenced with multidetector computed tomographic angiography ( @entity601 -CTA) images of the neck to define the study population. After standardizing the @entity601 -CTA windows, percent @entity850 was determined by cross-sectional area reduction using two separate previously described methods based on North American Symptomatic Carotid Endarterectomy Trial (NASCET) and European Carotid Surgery Trial (ECST) criteria. DUS waveform parameters in the internal carotid artery near the AcS were then compared with these @entity601 -CTA measurements to determine the accuracy of DUS in characterizing the severity of @entity543 . RESULTS: During this period, 8517 DUS studies were performed at the Massachusetts General Hospital, 550 of which had AcS, for an incidence of 6.45%. There were 92 lesions with a concomitant @entity601 -CTA; however, seven were excluded because of poor study quality, because >= 6  months had elapsed between DUS and @entity601 -CTA, or because the @entity1 had undergone carotid reconstruction between studies. Of the 85 remaining lesions, DUS characterized 17 as severe (peak systolic velocity [PSV] >250  cm/s), 31 as moderate (PSV  = 151-250  cm/s), and 37 as mild (PSV  <=150  cm/s) stenoses using PSV criteria. PSV weakly correlated with CTA-NASCET (r  = 0.361; P  = .004) and CTA-ECST (r  = 0.306; P  = .004) percent @entity850 . Using PSV >250  cm/s as the predictor of >70% @entity850 , and a >= 70% cutoff by both CTA-ECST and CTA-NASCET methods as the reference measure, DUS sensitivity ranged from 22.7% to 32.5%, specificity from 89.4% to 91.1%, positive predictive value from 88.2% to 76.4%, and negative predictive value from 25% to 60.2%. A subgroup analysis of lesions identified as non-severe by DUS revealed that waveforms with lower deceleration were associated with severe @entity850 on CTA. CONCLUSIONS: In the presence of AcS, DUS alone is inadequate to accurately determine the degree of @entity543 with sensitivity, specificity, and negative predictive values far below that needed for clinical decision-making. @entity601 -CTA may be necessary for improved characterization of plaque in these @entity75 . Further studies are needed to determine DUS parameters that may identify @entity1 who should undergo further evaluation with @entity601 -CTA to characterize the true severity of the @entity850 .

title: Acoustic shadowing impairs accurate characterization of XXXX in carotid ultrasound examinations.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['AcS lesions']

entities_list: @entity2270 :: ('MESH:C566610', 'Disease') :: ['longitudinal axis']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis', 'carotid artery stenosis']

answer: @entity850 :: (MESH:D003251,Disease) :: ['stenosis']


abstract: UNASSIGNED: Aim   The current study aimed to assess the perinatal risk of @entity9129 ( @entity9129 ) and to establish a suitable surgical strategy in consideration of postoperative lung growth and problems during adulthood. Methods   Among 874 @entity9129 @entity1 identified in a nationwide survey, 428 @entity1 were born between 1992 and 2012 and treated at 10 high-volume centers were retrospectively reviewed with statistical analysis. Results   In the 194 @entity1 who were prenatally diagnosed to have @entity9129 , 16.7% presented with fetal hydrops as observed using ultrasonography. The Apgar score (5 minutes) was lower than 5 in 5.4%. As of postnatal day 30, 14.0% of the neonatal @entity1 required respiratory support, and 3.3% (8/243) had died because of @entity358 . Among those who were asymptomatic immediately after birth, 33.6% of the @entity1 developed the @entity1576 during their first year of life, and 22.1% did so between the age of 1 and 2 years. The postoperative percent vital capacity among the prenatally diagnosed @entity1 was significantly higher than that among the postnatally diagnosed @entity1 (98.3        11.9 vs. 81.7        9.7, p   <   0.0222). Late complications included @entity85 in 30 @entity1 and persistent @entity358 in 4 @entity1 , whereas @entity5 was not observed in the present series. Conclusions   Approximately 10 to 15% of prenatally diagnosed @entity9129 @entity1 may carry a high risk of perinatal @entity649 . Early operation before developing episodes of @entity358 , seem to be associated with a better development of the reserved lung during later life. The incidence of @entity105 among @entity1 with @entity9129 may be extremely low.

title: Clinical Features of XXXX : A Report on a Nationwide Multicenter Study in Japan.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['respiratory distress']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['pulmonary hypoplasia', 'lung infection', 'lung cyst']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory infectious symptoms']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['thoracic deformity']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

entities_list: @entity9129 :: ('MESH:C563237', 'Disease') :: ['CCLD', 'congenital cystic lung diseases']

answer: @entity9129 :: (MESH:C563237,Disease) :: ['Congenital Cystic Lung Diseases']


abstract: INTRODUCTION: In @entity121 @entity1 it is useful to measure skeletal muscle forces. Conventional methods require voluntary muscle activation, which can be unreliable. We evaluated a device for non-voluntary force assessment. METHODS: We tested 8 @entity1 (unknown @entity121 n = 2, @entity5442 , @entity3986 , @entity3055 , @entity29731 , multi-minicore disease, @entity1555 , n = 1 each). Isometric twitch torques of ankle dorsiflexors were measured after fibular nerve stimulation. RESULTS: Six @entity1 had decreased torques vs. 8 controls ( @entity1 : median Newton-meter 1.6 vs 5.7, @entity1 : 0.2 vs 3.9, both P   <   0.0001). Values correlated with Manual Muscle Test results (r = 0.73, r(2) = 0.53, P   <   0.0001). In weak dorsiflexors, torque could be measured despite lower signal-to-noise ratio. In 2 @entity1 with @entity1184 we measured increased torques. DISCUSSION: Non-voluntary muscle force assessment can be used in @entity1 with @entity121 , and values correlate with voluntary forces determined by traditional methods. This article is protected by copyright. All rights reserved.

title: Isometric skeletal muscle force measurement in primary XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity29731 :: ('MESH:C537995', 'Disease') :: ['dysferlinopathy']

entities_list: @entity5442 :: ('MESH:D009220', 'Disease') :: ['inflammatory myopathy']

entities_list: @entity3055 :: ('MESH:D017240', 'Disease') :: ['mitochondrial myopathy']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity3986 :: ('MESH:D009136', 'Disease') :: ['facioscapulohumeral muscular dystrophy']

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ['Becker-Kiener muscular dystrophy']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['myopathy', 'myopathies']

answer: @entity121 :: (MESH:D009135,Disease) :: ['myopathies']


abstract: UNASSIGNED: A variety of skilled reaching tasks have been developed to evaluate forelimb function in rodent models. The single pellet skilled reaching task and pasta matrix task have provided valuable insight into recovery of forelimb function in models of @entity16 and disease. Recently, several automated measures have been developed to reduce the cost and time burden of forelimb assessment in rodents. Here, we provide a within-subject comparison of three common forelimb assessments to allow direct evaluation of sensitivity and efficiency across tasks. @entity35 were trained to perform the single pellet skilled reaching task, the pasta matrix task, and the isometric pull task. Once proficient on all three tasks, @entity35 received an ischemic lesion of motor cortex and striatum to impair use of the trained limb. On the second week post-lesion, all three tasks measured a significant @entity71 . Performance was well-correlated across tasks. By the sixth week post-lesion, only the isometric pull task measured a significant @entity71 , suggesting that this task is more sensitive to @entity73 . The number of training days required to reach asymptotic performance was longer for the isometric pull task, but the total experimenter time required to collect and analyze data was substantially lower. These findings suggest that the isometric pull task represents an efficient, sensitive measure of forelimb function to facilitate preclinical evaluation in models of @entity16 and disease.

title: A Within-Animal Comparison of Skilled Forelimb Assessments in XXXX .

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['chronic impairments']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological injury']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['deficit in forelimb function']

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: AIM: The main objective of this study is to demonstrate whether @entity1735 metabolism alterations identified in @entity1 with advanced @entity82 show any improvement after liver transplant. METHODS: The study included 86 @entity1 who underwent liver transplant between March 2010 and February 2011. An oral @entity413 tolerance test was performed before the liver transplant, and 6 and 12 months after. Beta cell function and @entity2690 resistance were also calculated, applying formulae that use basal plasma glycaemia and @entity2690 , and plasma glycaemia and @entity2690 during an oral @entity413 tolerance test. Risk factors for pre- and post-transplant @entity6 were also studied. The diagnosis of @entity6 was based on an OGTT. RESULTS: The proportion of @entity1 with @entity6 before transplant, and at month 6 and 12 after transplant were 70.9%, 48.8% and 39.2%, respectively. Compared to baseline, at month 6 the odds ratio of having @entity6 was 0.39 (IC 95% [0.21, 0.73]) and at month 12 it was 0.26 (IC 95% [0.14, 0.50]). The composite @entity2690 sensitivity index values at 6 and 12 months were 1.72 units higher (IC 95% [0.84, 2.58]) and 1.58 units higher (IC 95% [0.68, 2.44)] than baseline. A statistically significant association was found between high MELD values and high body mass index, and risk of pre-transplant @entity6 (p=0.001 and p=0.033, respectively). @entity82 aetiology did not influence the risk of @entity6 . CONCLUSIONS: In this study, we were able to ascertain that alterations in @entity1735 metabolism typical of advanced @entity82 improve after liver transplant. This improvement is mainly due to an improvement in @entity2690 resistance.

title: Alterations in XXXX metabolism in cirrhotic @entity1 before and after liver transplant.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis', 'Cirrhosis']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1735 :: (CHEBI:16646,Chemical) :: ['carbohydrate']


abstract: AIM: The main objective of this study is to demonstrate whether @entity1735 metabolism alterations identified in @entity1 with advanced @entity82 show any improvement after liver transplant. METHODS: The study included 86 @entity1 who underwent liver transplant between March 2010 and February 2011. An oral @entity413 tolerance test was performed before the liver transplant, and 6 and 12 months after. Beta cell function and @entity2690 resistance were also calculated, applying formulae that use basal plasma glycaemia and @entity2690 , and plasma glycaemia and @entity2690 during an oral @entity413 tolerance test. Risk factors for pre- and post-transplant @entity6 were also studied. The diagnosis of @entity6 was based on an OGTT. RESULTS: The proportion of @entity1 with @entity6 before transplant, and at month 6 and 12 after transplant were 70.9%, 48.8% and 39.2%, respectively. Compared to baseline, at month 6 the odds ratio of having @entity6 was 0.39 (IC 95% [0.21, 0.73]) and at month 12 it was 0.26 (IC 95% [0.14, 0.50]). The composite @entity2690 sensitivity index values at 6 and 12 months were 1.72 units higher (IC 95% [0.84, 2.58]) and 1.58 units higher (IC 95% [0.68, 2.44)] than baseline. A statistically significant association was found between high MELD values and high body mass index, and risk of pre-transplant @entity6 (p=0.001 and p=0.033, respectively). @entity82 aetiology did not influence the risk of @entity6 . CONCLUSIONS: In this study, we were able to ascertain that alterations in @entity1735 metabolism typical of advanced @entity82 improve after liver transplant. This improvement is mainly due to an improvement in @entity2690 resistance.

title: Alterations in @entity1735 metabolism in cirrhotic XXXX before and after liver transplant.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Current @entity2640 ( @entity2640 ) focuses on preventing secondary @entity281 -a leading cause of mortality-by regularly cleaning and bandaging blisters and @entity2681 and preventive bandaging of high-friction areas. Unfortunately the baths and showers used to remove bandages and clean the skin are often @entity158 , causing lack of adherence and subsequent increases in @entity281 , @entity158 , and antimicrobial use. This study evaluates the hypothesis that bathing individuals with @entity2640 in saltwater is less @entity158 than in normal bath water. The study also explores whether taking saltwater baths reduces @entity281 as measured through skin pruritus, odor, discharge, and nonbathing @entity158 . @entity1 recruited from the @entity1 's Hospital Colorado Outpatient @entity2640 Clinic completed standardized questionnaires assessing the effects of the clinic's saltwater bathing recommendations; the data were analyzed using frequencies and Fisher tests. After starting saltwater baths, @entity1 reported a significant reduction in @entity158 (91%), @entity158 medication use (66%), skin odor (31%), and skin discharge (44%). No significant differences were found with respect to the type of @entity2640 , age, length of time using baths, or amount of salt added. Saltwater baths are a noninvasive, low-cost, effective treatment that significantly reduces @entity158 , @entity158 medication use, and some signs of @entity272 . This treatment can be recommended to @entity1 with all studied @entity2640 types without regard to age, the specific amount of salt used, bathing frequency, or @entity158 level. Given the central role bathing and dressing changes play in the management of @entity2640 , the use of saltwater baths can lead to significant improvement in quality of life.

title: Effectiveness of saltwater baths in the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Children', 'Participants']

entities_list: @entity2640 :: ('MESH:D004820', 'Disease') :: ['EB', 'management of epidermolysis bullosa']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'bathing pain', 'painful']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin infection']

answer: @entity2640 :: (MESH:D004820,Disease) :: ['epidermolysis bullosa']


abstract: BACKGROUND AND OBJECTIVES: When surgery is not adequate or feasible, stereotactic body radiotherapy (SBRT) reirradiation has been used for recurrent @entity5 . We report the outcomes of a series of @entity1 with pelvic recurrences from @entity14 reirradiated with SBRT. METHODS: The Cyberknife(TM) Robotic Stereotactic Radiosurgery system with fiducial based real time tracking was used. @entity1 were followed with imaging of the pelvis. RESULTS: Four @entity1 and 14 @entity1 with 22 lesions were included. The mean dose was 25   Gy in median of five fractions. The mean prescription isodose was 77%, with a median maximum dose of 32.87   Gy. There were two local failures, with a crude local control rate of 89%. The median overall survival was 43 months. One @entity1 had @entity29 and required surgery (Grade IV), two @entity1 had symptomatic @entity16 (1 Grade III) and one @entity1 developed @entity3041 from ureteric @entity82 requiring a stent (Grade III). CONCLUSIONS: Local recurrence in the pelvis after modern combined modality treatment for @entity14 is rare. However it presents a therapeutic dilemma when it occurs; often symptomatic and eventually life threatening. SBRT can be a useful non-surgical modality to control pelvic recurrences after prior radiation for @entity14 . J. Surg. Oncol.    2015 Wiley Periodicals, Inc.

title: Stereotactic body radiotherapy (SBRT) reirradiation for pelvic recurrence from XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'men']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity29 :: ('MESH:D015212', 'Disease') :: ['small bowel perforation']

entities_list: @entity3041 :: ('MESH:D006869', 'Disease') :: ['hydronephrosis']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: UNASSIGNED: Severe GN involves local neutrophil extracellular @entity52643 (NET) formation. We hypothesized a local cytotoxic effect of NET-related histone release in @entity39 GN. In vitro, histones from @entity291 thymus or histones released by neutrophils undergoing NETosis killed glomerular endothelial cells, podocytes, and parietal epithelial cells in a dose-dependent manner. Histone-neutralizing agents such as antihistone IgG, activated protein C, or heparin prevented this effect. Histone @entity137 on glomeruli ex vivo was @entity26789 dependent, and lack of @entity26789 attenuated histone-induced renal @entity9818 and @entity8 in mice. Anti-glomerular basement membrane GN involved NET formation and vascular @entity39 , whereas blocking NET formation by peptidylarginine inhibition or preemptive anti-histone IgG injection significantly reduced all aspects of GN (i.e., vascular @entity39 , podocyte loss, @entity633 , cytokine induction, recruitment or activation of glomerular leukocytes, and glomerular crescent formation). To evaluate histones as a therapeutic target, @entity19 with established GN were treated with three different histone-neutralizing agents. Anti-histone IgG, recombinant activated protein C, and heparin were equally effective in abrogating severe GN, whereas combination therapy had no additive effects. Together, these results indicate that NET-related histone release during GN elicits cytotoxic and immunostimulatory effects. Furthermore, neutralizing extracellular histones is still therapeutic when initiated in established GN.

title: Neutrophil Extracellular XXXX -Related Extracellular Histones Cause Vascular Necrosis in Severe GN.

entities_list: @entity9818 :: ('MESH:D057049', 'Disease') :: ['thrombotic microangiopathy']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['glomerular necrosis']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'necrotizing']

entities_list: @entity633 :: ('MESH:D000419', 'Disease') :: ['albuminuria']

answer: @entity52643 :: (20832(Tax:10090),Gene) :: ['Trap']