abstract: Progress in the treatment of childhood @entity3052 has not equalled the advances obtained in the management of @entity981 . Two recent chemotherapy studies (i.e. @entity16897 and @entity59275 ), however, reported marked increase in the proportion of long-term remissions. The initial therapy of the cooperative study @entity59275 consisted of two 4-week phases of intensive induction/consolidation with 7 different drugs and cranial irradiation followed by maintenance with @entity332 and @entity2592 for 2 years and additional @entity632 during the first year. A total of 151 @entity1 with @entity3052 were enrolled in the study from 30 centers. Of these 119 (79%) @entity1 achieved complete remission. After a median observation time of 34 (14-57) months, there have been 46 relapses. CNS was involved in 6 of these relapses. Life table analyses revealed the following probabilities after 4 1/2 years: survival: 46%; disease-free survival: 41% (total group), 52% (remission group); disease-free interval 56% (remission group). The risk of relapse appears to decrease considerably after 2 1/2 years. No risk factors for the occurrence of relapse have been identified.

title: Treatment of @entity3052 in XXXX .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: Lung @entity5 survivors are at an increased risk for recurrence and the development of secondary @entity5 and other comorbid conditions. However, little is known about @entity2 survivors' risk behaviors and the effect of these behaviors on overall health perceptions. OBJECTIVE: The purpose of this study was to describe the prevalence of health risk behaviors among @entity1149 survivors and their relationship perception to overall health. METHODS: One hundred forty-two survivors of @entity1149 with a minimum of 5 years disease free completed a battery of questionnaires to assess perception of health status and self-reported risk behaviors (smoking, exposure to secondhand smoke, @entity167 use) and weight before and after diagnosis. Urinary @entity4874 level was used to verify smoking status, and actual height and weight were obtained to determine overweight status (body mass index, >/=25). Descriptive statistics and logistic regression were used to analyze the data. RESULTS: Seventy percent of @entity1 reported their health as good to excellent. Although 81% quit smoking after diagnosis, 13.4% continued to smoke and 28% reported exposure to secondhand smoke. Approximately half the sample (58%) drank @entity167 (16.3% quit after diagnosis) and was overweight (51%). A strong agreement between current smoking and exposure to secondhand smoke was observed. In a multivariate analysis, smoking (odds ratio [OR], 7.02; CI, 2.45 to 20.13), exposure to secondhand smoke (OR, 5.37; CI, 2.42 to 11.95), @entity167 use (OR, 9.04; CI, 3.28 to 24.92), and overweight (OR, 8.51; CI, 3.44 to 21.10) were independent predictors of perceived poor health status. CONCLUSION: Although most @entity2 survivors have made healthy lifestyle changes, a substantial proportion has not. Our findings suggest the need for multiple risk factor interventions to decrease risk behaviors and improve overall health after a @entity5 diagnosis.

title: Health perceptions and risk behaviors of XXXX survivors.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity4874 :: ('MESH:D003367', 'Chemical') :: ['cotinine']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: CONTEXT: The "Standards, Options and Recommendations" (SOR) project, started in 1993, is a collaboration between the Federation of French @entity5 centers (FNCLCC), the 20 French @entity5 centers, scientific societies, and specialists from French public universities, general hospitals and private clinics. The main objective is the development of clinical practice guidelines to improve the quality of health care and the outcome of @entity5 @entity1 . The methodology is based on a literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in @entity5 care delivery. OBJECTIVES: To develop clinical practice guidelines for the use of positron emission tomography with @entity419 in oncology according to the definitions of the Standards, Options and Recommendations project. METHODS: More than 600 articles were identified by searching Medline, web sites, and using the personal reference lists of members of the expert groups. Once the guidelines were defined, the document was submitted for review to independent reviewers (n = 82). RESULTS: The different steps in @entity1 care are studied in this report: diagnosis of the @entity66 , initial and secondary assessment of metastatic extension, evaluation of treatment response and examination for recurrence. The guidelines were developed for each @entity5 sites: bronchopulmonary and @entity5 , @entity320 , gynaecological @entity5 , @entity1820 , @entity135 , @entity5 , @entity706 , soft-tissue and @entity79 , @entity5 of unknown primary site. The recommendations were made on the basis of data published up to February 2002. Systematic monitoring of the new scientific data on FDG-PET has been set up by the working group of the FNCLCC, which will ensure dissemination of the updating on its web site: www.fnclcc.fr/sor.htm.

title: [Standards, Options and Recommendations 2002 for the use of Positron Emission Tomography with XXXX (PET-FDG in cancerology (integral connection].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancers']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['primary disease']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers of the thyroid and carcinomas', 'cancers', 'cancer', 'urological cancers', 'pleural cancers']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone sarcomas']

entities_list: @entity1820 :: ('MESH:D005770', 'Disease') :: ['gastrointestinal cancers']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanomas']

answer: @entity419 :: (MESH:D019788,Chemical) :: ['[18F]-FDG']


abstract: After greater than 60 gray (Gy) irradiation, we performed the pulmonary resection in the 18 primary @entity2 cases. The mean irradiation dose to the @entity5 was 68.2 (range 60-101) Gy, and the mean irradiation dose to the bronchial stump was 47.1 (range 0-82) Gy. Median time from end of irradiation to surgical resection was 136 (range 20-894) days. One partial resection, 9 single lobectomies, 3 double lobectomies, and 5 pneumonectomies were done. Mainly, we closed the bronchial stump by the automatic stapling device and additional hand suturing. The bronchial stump was covered in the 12 cases by the owner stalk thymus, the intercostals muscular flap, the omentum flap, and et al. The major @entity260 due to preoperative irradiation were not seen. @entity292 did not occur. Pathologically, the wall of the submucosal capillary vessels were getting thick in the @entity1 operated more than 3 months later after irradiation. In such cases with the decrease of the blood flow, the bronchial stump should be covered. The pulmonary resection after the high dose irradiation was considered to be tolerable.

title: [Resected cases with primary XXXX after preoperative high dose irradiation].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['Bronchopleural fistulas']

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: OBJECTIVE: Our aim was to evaluate the subsequent obstetrical outcome and rate of uterine @entity397 following a caesarean section before 32 weeks of gestation. @entity1 AND METHODS: A retrospective cohort study of 200 consecutive @entity1 with a prior caesarean section performed between 25 and 32 weeks were contacted by questionnaire or followed through medical charts to determine the subsequent mode of delivery. RESULTS: Two hundred caesarean section were performed between 25 and 32 weeks from January 1997 to March 2000. Thirty-nine @entity1 (19.2%) were lost to follow-up. Seventy-one @entity1 had a subsequent delivery. Thirty-two attempted vaginal birth and the success rate was 87.5%. Thirty-nine @entity1 had a subsequent caesarean. One case of uterine @entity397 occurred before labour at 31 weeks (1.4%, % IC 95% [0.25; 7.56]). CONCLUSION: After a previous caesarean delivery before 32 weeks, a trial of labour may be proposed when obstetrical conditions are optimal. However, uterine @entity397 may occur prior to labor.

title: [Obstetrical outcome and risk of uterine XXXX following a caesarean section before 32 weeks].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'women', 'PATIENTS']

answer: @entity397 :: (MESH:D012421,Disease) :: ['rupture']


abstract: OBJECTIVE: To study the bone conductive @entity393 in @entity2346 media with effusion (OME). METHOD: Fifty adults of OME treated in our hospital, from Mar. 2009 to Feb. 2010, were enrolled for analyzing bone conduction @entity393 (BCHL) before auripuncture and after auripuncture, the difference between which were compared in 51 ears. BCT of pre auripuncture 24 subjects, BCT of post-auripuncture 22 subjects, and BCT recovered from OME 9 subjects compared with the contralateral ear respectively. High and extend high frequency (8, 10, 12, 16 kHz) air conduction threshold (ACT) after recover from OME was compared to the normal contralateral ear in 4 adults. RESULT: BCT improved significantly after auripuncture at the frequencies (0.5-4.0 kHz), and the improvements in 4.0 kHz are more than that in 0.5 kHz significantly (P<0.05). In the unilateral OME subjects, BCT, of post auripuncture and recovered from OME, nearly recovered to the same level as the contralateral ear in most cases. While high and extend-high frequency (8, 10, 12, 16 kHz) ACT elevated in 3 of 4 @entity1 recovered from OME. CONCLUSION: Both effusion in middle ear and @entity389 result in the elevation of BCT. Elevation of BCT at regular frequencies (0.5-4.0 kHz) is frequently associated with the effusion in middle ear, while these frequencies were insensitive in the early @entity389 . The high and extend high frequency ACT elevation may be sensitive for the early @entity1274 . As the disease prolonged, @entity1274 of the lower frequencies (0.5-4.0 kHz) could be detected of OME @entity1 .

title: [A primary study of bone conduction XXXX in adults with @entity2346 media with effusion].

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss']

entities_list: @entity389 :: ('MESH:D007759', 'Disease') :: ['inner ear injury', 'injury in inner ear could']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['hearing loss']

entities_list: @entity2346 :: ('MESH:D010031', 'Disease') :: ['adults of otitis']

answer: @entity393 :: (MESH:D034381,Disease) :: ['hearing loss']


abstract: OBJECTIVE: To study the bone conductive @entity393 in @entity2346 media with effusion (OME). METHOD: Fifty adults of OME treated in our hospital, from Mar. 2009 to Feb. 2010, were enrolled for analyzing bone conduction @entity393 (BCHL) before auripuncture and after auripuncture, the difference between which were compared in 51 ears. BCT of pre auripuncture 24 subjects, BCT of post-auripuncture 22 subjects, and BCT recovered from OME 9 subjects compared with the contralateral ear respectively. High and extend high frequency (8, 10, 12, 16 kHz) air conduction threshold (ACT) after recover from OME was compared to the normal contralateral ear in 4 adults. RESULT: BCT improved significantly after auripuncture at the frequencies (0.5-4.0 kHz), and the improvements in 4.0 kHz are more than that in 0.5 kHz significantly (P<0.05). In the unilateral OME subjects, BCT, of post auripuncture and recovered from OME, nearly recovered to the same level as the contralateral ear in most cases. While high and extend-high frequency (8, 10, 12, 16 kHz) ACT elevated in 3 of 4 @entity1 recovered from OME. CONCLUSION: Both effusion in middle ear and @entity389 result in the elevation of BCT. Elevation of BCT at regular frequencies (0.5-4.0 kHz) is frequently associated with the effusion in middle ear, while these frequencies were insensitive in the early @entity389 . The high and extend high frequency ACT elevation may be sensitive for the early @entity1274 . As the disease prolonged, @entity1274 of the lower frequencies (0.5-4.0 kHz) could be detected of OME @entity1 .

title: [A primary study of bone conduction @entity393 in adults with XXXX media with effusion].

answer: @entity2346 :: (MESH:D010031,Disease) :: ['otitis']


abstract: PURPOSE: The purpose of this study was to develop and validate an animal model of drug disposition in synovial fluid (SF) by comparing microdialysis with arthrocentesis using the anti-arthritic drug @entity1499 ( @entity1500 ). METHODS: Microdialysis probes were calibrated in vitro with the no net flux method using @entity235 synovial fluid. The probes were implanted surgically into the stifle joint space of four @entity235 and were dialyzed overnight using a portable microinfusion pump. The membrane integrity of the probes was monitored by retrodialysis using an internal standard. After an intravenous bolus of 2.5 mg/kg of @entity1500 , unbound concentrations in synovial fluid, as well as total plasma concentrations, were measured by liquid chromatography tandam mass spectrometer (LC/MS/MS) in samples collected from 0 to 48 h postdose. RESULTS: The probe membrane remained intact at least 48 h after implantation. The mean probe recovery and unbound fraction of @entity1500 in SF were 46.8% and 44.8%, respectively. The unbound fraction of @entity1500 was 44% in synovial fluid. @entity1500 penetrated into the joint space rapidly, with maximal concentrations of 6.6 microM reached at approximately 1 h postdose. The unbound @entity1500 area under the curve in SF was approximately 40% of the total area under the curve in plasma. These data agree well with the previous data obtained for @entity1500 using arthrocentesis. CONCLUSION: In contrast with arthrocentesis, microdialysis enables the collection of multiple serial SF samples from individual animals with minimal @entity130 and potential blood contamination. This animal model should prove valuable for studying the disposition of new antiarthritis compounds or biomarkers in SF.

title: Development of a @entity235 microdialysis model for determining synovial fluid pharmacokinetics of anti-arthritis compounds exemplified by XXXX .

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: PURPOSE: The purpose of this study was to develop and validate an animal model of drug disposition in synovial fluid (SF) by comparing microdialysis with arthrocentesis using the anti-arthritic drug @entity1499 ( @entity1500 ). METHODS: Microdialysis probes were calibrated in vitro with the no net flux method using @entity235 synovial fluid. The probes were implanted surgically into the stifle joint space of four @entity235 and were dialyzed overnight using a portable microinfusion pump. The membrane integrity of the probes was monitored by retrodialysis using an internal standard. After an intravenous bolus of 2.5 mg/kg of @entity1500 , unbound concentrations in synovial fluid, as well as total plasma concentrations, were measured by liquid chromatography tandam mass spectrometer (LC/MS/MS) in samples collected from 0 to 48 h postdose. RESULTS: The probe membrane remained intact at least 48 h after implantation. The mean probe recovery and unbound fraction of @entity1500 in SF were 46.8% and 44.8%, respectively. The unbound fraction of @entity1500 was 44% in synovial fluid. @entity1500 penetrated into the joint space rapidly, with maximal concentrations of 6.6 microM reached at approximately 1 h postdose. The unbound @entity1500 area under the curve in SF was approximately 40% of the total area under the curve in plasma. These data agree well with the previous data obtained for @entity1500 using arthrocentesis. CONCLUSION: In contrast with arthrocentesis, microdialysis enables the collection of multiple serial SF samples from individual animals with minimal @entity130 and potential blood contamination. This animal model should prove valuable for studying the disposition of new antiarthritis compounds or biomarkers in SF.

title: Development of a XXXX microdialysis model for determining synovial fluid pharmacokinetics of anti-arthritis compounds exemplified by @entity1499 .

answer: @entity235 :: (9615,Species) :: ['dog']


abstract: OBJECTIVE: To evaluate capsule endoscopy in terms of incomplete examinations and capsule retentions, to describe the characteristic of these events and to find risk factors for these events. METHODS: This retrospective and consecutive case-control study includes data of 204 capsule enteroscopy examinations in @entity1 with @entity30 , performed at the first hospital affiliated to zhejiang university medical school from June 2003 to April 2014. RESULTS: The frequency of complete examinations was 56.9%. Male gender (OR=2.48, P=0.026), @entity490 (OR=2.88, P=0.002), melena/bloody stools/OB+ (OR=3.34, P=0.009) were risk factors for an incomplete examination. Capsule retention occurred in 8.33% (n=17). The ratio of male and female was 12:5. While the average age of these @entity1 was 42.2  16.2, and the average course of disease was 52.5  46.6 months. Of the seventeen cases of retained capsules, four @entity1 chose to undergo surgery to remove the capsule for occurring symptoms of @entity1321 , spontaneous passage occurred in twelve @entity1 after medical treatment, and one @entity1 still have the capsule retained after 16 months of expectation. The longest capsule retained time in @entity1 was four years. Risk factors for capsule retention was abdominal distention (OR=8.45, P=0.006). CONCLUSIONS: The majority of capsule endoscopy retention develops into spontaneous passage after medical treatment. Therefore capsule endoscopy is considered a safe procedure, although obstructive symptoms and serious complications due to capsule retention can be found in @entity1 with known @entity30 .

title: The clinical characteristic and risk of capsule incomplete and retention in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's Disease", "Crohn's disease"]

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

answer: @entity30 :: (MESH:D003424,Disease) :: ['Crohn's disease']


abstract: BACKGROUND AND OBJECTIVES: Low-level laser therapy (LLLT) has been shown to promote chronic wound healing in conditions of reduced microcirculation. In this preliminary study, we report the results of using LLLT to heal foot @entity1066 in @entity1 with @entity6 . MATERIALS AND METHODS: Twenty-three @entity1 with a @entity6 foot wound for at least 3 months were included in this double-blind randomized clinical trial. @entity1 were randomized to receive placebo treatment (n = 10) or LLLT (n = 13) (685 nm, energy density 10 J/cm(2)) in addition to conventional therapy. @entity1 were followed for 20 weeks. Ulcer size reduction and the number of @entity1 with complete healing were compared between the LLLT and placebo groups. RESULTS: There were no significant differences in baseline characteristics of @entity1 and foot @entity1066 receiving LLLT and placebo treatment. At week 4, the size of @entity1066 decreased significantly in the LLLT group (p = 0.04). After 20 weeks, in the LLLT group, eight @entity1 had complete healing and in the placebo group only three @entity1 experienced complete wound healing. The mean time of complete healing in LLLT @entity1 (11 weeks) was less than that in placebo @entity1 (14 weeks) though the difference was not statistically significant. CONCLUSIONS: The study provides evidence that LLLT can accelerate the healing process of chronic @entity4760 , and it can be presumed that LLLT may shorten the time period needed to achieve complete healing.

title: A randomized clinical trial on the effect of low-level laser therapy on chronic XXXX foot wound healing: a preliminary report.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic', 'diabetes mellitus']

entities_list: @entity4760 :: ('MESH:D017719', 'Disease') :: ['diabetic foot ulcers']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic']


abstract: @entity1721 ( @entity1721 ) is one of the most common and deadly causes of @entity5 worldwide. However, to date, the mechanisms underlying its pathogenesis remain unclear. The present study investigated the gene expression profile of @entity1 @entity418 cell line TE-1, a cell model for @entity1721 , to gain insight to the genetic regulation of this disease. @entity1 @entity418 TE-1 cells and normal esophageal @entity1 cells were cultured for isolation of total RNA. Differential expression of RNA transcripts was assessed using the Agilent 4*44 K microarray, combined with real-time PCR (qRT-PCR) for validation. Classification and function of the differential genes were illustrated by bioinformatics processing including hierarchical clustering and gene ontology (GO) analysis. We identified 4,986 transcripts with differential expression (fold-change >= 1.5, P<0.05), including 2,368 up-regulated and 2,618 down-regulated transcripts. GO analysis showed that the dysregulated transcripts were associated with biological process, cellular component, and molecular function. After bioinformatic analysis of significantly regulated signaling pathways, we found these transcripts may target 35 gene pathways, including @entity876 signaling, @entity11 , ubiquitin-mediated proteolysis, insulin signaling, cell cycle, @entity19260 metabolism, @entity3470 signaling, and MAPK signaling. The differentially expressed transcripts were screened between the @entity418 cell line TE-1 and normal esophageal cell line HET-1A, as well as their target gene pathways. Further data mining is related to prevention and treatment of @entity418 .

title: Gene expression profile of @entity1 XXXX cell line TE-1.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1721 :: ('MESH:C562729', 'Disease') :: ['ESCC', 'Esophageal squamous cell carcinoma']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

entities_list: @entity19260 :: ('CHEBI:24846', 'Chemical') :: ['inositol phosphate']

answer: @entity1721 :: (MESH:C562729,Disease) :: ['esophageal squamous carcinoma']


abstract: @entity1721 ( @entity1721 ) is one of the most common and deadly causes of @entity5 worldwide. However, to date, the mechanisms underlying its pathogenesis remain unclear. The present study investigated the gene expression profile of @entity1 @entity418 cell line TE-1, a cell model for @entity1721 , to gain insight to the genetic regulation of this disease. @entity1 @entity418 TE-1 cells and normal esophageal @entity1 cells were cultured for isolation of total RNA. Differential expression of RNA transcripts was assessed using the Agilent 4*44 K microarray, combined with real-time PCR (qRT-PCR) for validation. Classification and function of the differential genes were illustrated by bioinformatics processing including hierarchical clustering and gene ontology (GO) analysis. We identified 4,986 transcripts with differential expression (fold-change >= 1.5, P<0.05), including 2,368 up-regulated and 2,618 down-regulated transcripts. GO analysis showed that the dysregulated transcripts were associated with biological process, cellular component, and molecular function. After bioinformatic analysis of significantly regulated signaling pathways, we found these transcripts may target 35 gene pathways, including @entity876 signaling, @entity11 , ubiquitin-mediated proteolysis, insulin signaling, cell cycle, @entity19260 metabolism, @entity3470 signaling, and MAPK signaling. The differentially expressed transcripts were screened between the @entity418 cell line TE-1 and normal esophageal cell line HET-1A, as well as their target gene pathways. Further data mining is related to prevention and treatment of @entity418 .

title: Gene expression profile of XXXX @entity1721 cell line TE-1.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: PURPOSE: The purpose of this prospective study was to evaluate the efficiency, feasibility, and surgical outcomes of microlaparoscopy-assisted pull-through (MAPT) for @entity1963 . METHODS: Starting in 2005, pull-through procedures for @entity1963 were performed exclusively using 2-mm instruments and miniscopes (microlaparoscopy). Three miniports were inserted laterally in the right abdominal wall in one line, with the miniscope at the level of the umbilicus and the working trocars cranially/caudally of the scope. The left colon was dissected, and transanal pull-through was performed. RESULTS: MAPT was performed in 16 @entity1 (10 @entity1 and 6 @entity1 ; average age: 5.7 months). Six @entity1 had previous abdominal surgeries. A 1.9-mm cystoscope or a 2.4-mm arthroscope was used in the first 5 cases. In the remainder, a recently developed 2.4-mm miniscope was used for visualization. The length of the resected colon segment was up to the left colonic flexur in 5 @entity1 , up to the middle of the descending colon in 4 cases and up to the sigmoid-descending segment in 7 @entity1 . The average operation time was 185 minutes (range: 120-330 minutes). The only intraoperative complication that occurred was an injury of the right iliac vein by inadvertent slippage of an electrocautery hook requiring laparotomy. At follow-up, 80% of the parents were unable to identify the scars after microlaparoscopy. CONCLUSION: MAPT is a safe and practical procedure regardless of age or previous surgery.

title: A microlaparoscopically assisted pull-through procedure for XXXX : initial experiences.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'girls', 'boys']

entities_list: @entity1963 :: ('MESH:D006627', 'Disease') :: ["Hirschsprung's disease"]

answer: @entity1963 :: (MESH:D006627,Disease) :: ['Hirschsprung's disease']


abstract: The authors report here robust autophagy observed by electron microscopy in both the Echigo-1 strain of @entity3605 in hamsters and the Fujisaki strain of Gerstmann-Str  ussler-Scheinker disease in @entity19 . In both models, autophagic vacuoles were observed in several cellular compartments. In neuronal cell bodies, autophagic vacuoles of different size were seen. The cytoplasm of some neurons also contained semicircular cisterns equivalent to an early autophasophore. The major target of autophagy was @entity3986 , i.e., enlarged neuritic processes--mostly dendrites but also axonal terminals and preterminals. They contained numerous double- or multiple-membrane-bound autophagosomes or autophagolysosomes and large multivesicular bodies. Multivesicular bodies were also observed within autophagic vacuoles, and large multivesicular bodies were seen within synaptic terminals. Some @entity3986 was filled almost completely with multivesicular bodies; the latter were occasionally confluent. The authors conclude that autophagy is an important part of @entity1579 . They also suggest that spongiform vacuoles, a hallmark for the whole group of @entity1579 , may in reality originate from autophagic vacuoles.

title: Autophagy contributes to widespread neuronal degeneration in hamsters infected with the Echigo-1 strain of XXXX and @entity19 infected with the Fujisaki strain of Gerstmann-Str  ussler-Scheinker (GSS) syndrome.

entities_list: @entity3986 :: ('MESH:D009136', 'Disease') :: ['dystrophic neurites']

entities_list: @entity1579 :: ('MESH:D017096', 'Disease') :: ['prion diseases', 'neuropathology in prion disease']

entities_list: @entity3605 :: ('MESH:D007562', 'Disease') :: ['Creutzfeldt-Jakob disease']

answer: @entity3605 :: (MESH:D007562,Disease) :: ['Creutzfeldt-Jakob disease']


abstract: The authors report here robust autophagy observed by electron microscopy in both the Echigo-1 strain of @entity3605 in hamsters and the Fujisaki strain of Gerstmann-Str  ussler-Scheinker disease in @entity19 . In both models, autophagic vacuoles were observed in several cellular compartments. In neuronal cell bodies, autophagic vacuoles of different size were seen. The cytoplasm of some neurons also contained semicircular cisterns equivalent to an early autophasophore. The major target of autophagy was @entity3986 , i.e., enlarged neuritic processes--mostly dendrites but also axonal terminals and preterminals. They contained numerous double- or multiple-membrane-bound autophagosomes or autophagolysosomes and large multivesicular bodies. Multivesicular bodies were also observed within autophagic vacuoles, and large multivesicular bodies were seen within synaptic terminals. Some @entity3986 was filled almost completely with multivesicular bodies; the latter were occasionally confluent. The authors conclude that autophagy is an important part of @entity1579 . They also suggest that spongiform vacuoles, a hallmark for the whole group of @entity1579 , may in reality originate from autophagic vacuoles.

title: Autophagy contributes to widespread neuronal degeneration in hamsters infected with the Echigo-1 strain of @entity3605 and XXXX infected with the Fujisaki strain of Gerstmann-Str  ussler-Scheinker (GSS) syndrome.

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: AIM: The aim of this study was to compare endoloops and endostaples for closing the stump of the appendix during laparoscopic appendectomy (LA) for @entity698 in @entity1 . METHODS: All LA performed for @entity698 from 2005 to 2009 were analyzed prospectively. Cases of @entity532 such as @entity698 or @entity6177 were excluded, leaving 75 cases closed with loops and 81 cases closed with staples. Choice of technique was determined by the attending surgeon's preference. All @entity1 were managed according to the same pre-, intra-, and postoperative protocols. RESULTS: There were no significant differences between mean age at surgery, gender ratio, preoperative mean white blood cell count and mean @entity1851 , histopathologic findings, mean duration of surgery, and mean hospitalization. There were no intra-operative complications in either group, but one loop case required conversion to open surgery (P   =   NS). There were no significant differences in the incidences of @entity6177 , transient @entity2737 . The postoperative readmission rate for management of complications was 4.0% for loop cases and 2.5% for staple cases (P   =   NS). Overall, using staples for a standard LA (anesthesia and stump closure) was U.S.  405 more expensive than when loops were used. CONCLUSION: This is the first prospective study comparing endoloops with endostaples for closing the stump of the appendix during LA for @entity698 in @entity1 . Although stapling proved to be more expensive, the choice of technique should reflect the surgeon's experience and confidence to ensure that the @entity1 has the safest possible LA.

title: A prospective analysis of endoloops and endostaples for closing the stump of the appendix in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity698 :: ('MESH:D001064', 'Disease') :: ['perforated appendicitis', 'uncomplicated appendicitis', 'appendicitis']

entities_list: @entity6177 :: ('MESH:D018784', 'Disease') :: ['intra-abdominal abscess']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['complicated appendicitis']

entities_list: @entity2737 :: ('MESH:D014946', 'Disease') :: ['ileus, small bowel obstruction, and wound infection']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND: Much controversy exists regarding the initial choice of antibiotics and selected outcomes for @entity1 with @entity497 ( @entity497 ). METHODS: The investigators analyzed a hospital claims-made database to assess the impact of initial antibiotic choice on 30-day mortality, total hospital costs, and hospital length of stay (LOS). Fine risk groups allowed for stratification for variations in the severity of illness. @entity1 were divided into five monotherapy groups (ie, @entity2756 , "other" @entity2886 , @entity2887 , @entity7187 , or penicillins) and four groups that received dual therapy (ie, the agents listed above, except @entity7187 ) plus @entity7187 . @entity1 also were stratified by age (ie, > 65 years of age and < 65 years of age). Severely ill @entity1 were excluded. RESULTS: Overall, 44,814 @entity1 met the criteria for inclusion. Among monotherapy @entity1 , those who received @entity7187 had the least mortality but were the least ill. @entity1 who received dual therapy generally had shorter LOSs, lower total hospital charges, and decreased mortality compared with those who received monotherapy. Differences among dual-therapy regimens regarding outcomes studies were noted. @entity1 who were < 65 years of age had lower mortality rates, shorter LOSs, and lower hospital charges than did the more elderly @entity1 . Within this group, those who received dual therapy had better outcomes than those who received monotherapy. CONCLUSIONS: We confirmed the value of dual therapy employing @entity7187 as a second agent in decreasing mortality from @entity497 , and we provided similar data regarding shorter LOSs and lower hospital charges. This appears to hold for a younger population. Differences among dual-therapy regimens (all employing @entity7187 ) appear to exist and may be clinically relevant.

title: Impact of initial antibiotic choice on clinical outcomes in XXXX : analysis of a hospital claims-made database.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'persons']

entities_list: @entity2756 :: ('MESH:D002443', 'Chemical') :: ['ceftriaxone']

entities_list: @entity2886 :: ('MESH:D002511', 'Chemical') :: ['cephalosporins']

entities_list: @entity2887 :: ('MESH:D024841', 'Chemical') :: ['fluoroquinolones']

entities_list: @entity497 :: ('MESH:D003147', 'Disease') :: ['CAP', 'community-acquired pneumonia']

entities_list: @entity7187 :: ('MESH:D018942', 'Chemical') :: ['macrolides']

answer: @entity497 :: (MESH:D003147,Disease) :: ['community-acquired pneumonia']


abstract: BACKGROUND: Diet has been identified as a major determinant of @entity14 ( @entity14 ) but little is known of its influence on @entity14 survival. AIMS: To study the influence of dietary factors on survival in @entity1 who had undergone potentially curative @entity14 surgery. @entity1 : Among 171 @entity1 included in a case control study of @entity14 aetiological factors, 10 year survival data on 148 @entity1 who underwent resection of the @entity5 for potential cure were obtained from a Registry of Digestive Tumours. METHODS: Tertiles of food and nutrient intakes were entered into Cox proportional hazards survival models, controlling for age, sex, @entity5 stage, and @entity5 location. RESULTS: Only five year survival was influenced by the pre-diagnosis diet. High energy intake, as a result of high @entity1735 , protein, and lipid intake, was strongly related to increased survival. Five year relative risk of @entity204 for the highest versus the two lowest tertiles of energy intake was 0.18 (95% confidence interval 0.07; 0.44). This effect was similar in both sexes, for the colon and for the rectum. It was stronger in @entity1 with N+/M+ @entity5 (relative risk 0.06) than in those with less advanced @entity5 (relative risk 0.37; stage-energy interaction term non-significant). No specific food or nutrient could be identified as having prognostic significance. CONCLUSIONS: Whether high energy intake selects less severe tumoral clones or modifies antitumoral immunity remains unclear. Larger series need to be investigated before conducting intervention studies but our findings should prompt nutritional follow up in @entity14 @entity1 .

title: Influence of dietary factors on XXXX survival.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumours', 'tumour']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['CRC', 'colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: Eighty-two localized fibrous @entity5 of the pleura (LFTP) were reviewed retrospectively for the clinical, pathologic, and radiologic findings. Forty-four @entity1 and 38 @entity1 ranged in age from 17 to 78 years (mean, 54.7 years). Sixty-four benign LFTP ranged in size from 2 to 30 cm (mean, 13.2 cm), and 18 @entity5 ranged from 3 to 23 cm (mean, 14.4 cm). Forty-eight @entity1 (60%) presented with symptoms. Radiographs of 76 @entity1 demonstrated solitary masses occupying or extending into the inferior hemithorax (79%). Computed tomography (CT) of 78 lesions demonstrated lobular masses (83%) that formed at least one acute angle (96%) or only acute angles (65%) with the adjacent pleura. @entity75 attenuation was documented in 88% of enhanced and in 68% of unenhanced CT scans. Contrast enhancement was common (62% of cases). Magnetic resonance (MR) imaging of 18 lesions demonstrated heterogeneous signal intensity on both T1- and T2-weighted images (78% and 83%, respectively). Multiplanar MR imaging allowed visualization of the diaphragm and documentation of an intrathoracic mass in all cases. LFTP are solitary lobular heterogeneous masses that occur in symptomatic adults and often affect the inferior hemithorax. @entity5 are radiologically indistinguishable from those with benign histologic characteristics. Radiographic and CT features characteristic of pleural location are typically absent.

title: From the archives of the AFIP: Localized fibrous XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumors', 'Malignant lesions', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['Heterogeneous lesion']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor of the pleura']


abstract: AIM: This article discusses the clinical implications of adverse health outcomes derived during heatwaves for @entity1 with @entity146 , substance misuse and those taking prescribed medications such as @entity1091 , various neuroleptic and anticholinergic drugs. BACKGROUND: With climate change it is predicted that the incidence of prolonged periods of extreme heat will increase. Specific adverse health outcomes associated with high environmental temperatures include @entity64 and heat exhaustion. Those at increased risk for heat-related mortality are those with chronic health conditions, including those with @entity146 and substance misuse. DATA SOURCES: Sources of evidence included and 'grey' literature published between 1985 and 2010, such as key texts, empirical research, public policies, training manuals and community information sheets on heat waves. DISCUSSION: Current clinical practice and clinical impact of heatwaves on those @entity1 with comorbidity is explored. This includes the physiological components of heat stress, heat regulation, and the impact of @entity167 and other drugs; and, ramifications and professional practice issues for those with mental health conditions and those requiring mental health medications. IMPLICATIONS FOR NURSING: Client education covering modification of the environment and the use of client heat safety action plans. Secure, accessible stores of prescribed medication are recommended and emergency substance withdrawal kits could be made available. CONCLUSION: All nurses have a responsibility to increase the capability and resilience of their clients to manage their chronic health needs during a heatwave. At these times nurses need to give extra monitoring and assistance when clients lack the capacity or resources to protect themselves.

title: Heatwaves and their impact on @entity1 with XXXX , drug and mental health conditions: a discussion paper on clinical practice considerations.

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['heat stroke']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental health disorders']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']


abstract: AIM: This article discusses the clinical implications of adverse health outcomes derived during heatwaves for @entity1 with @entity146 , substance misuse and those taking prescribed medications such as @entity1091 , various neuroleptic and anticholinergic drugs. BACKGROUND: With climate change it is predicted that the incidence of prolonged periods of extreme heat will increase. Specific adverse health outcomes associated with high environmental temperatures include @entity64 and heat exhaustion. Those at increased risk for heat-related mortality are those with chronic health conditions, including those with @entity146 and substance misuse. DATA SOURCES: Sources of evidence included and 'grey' literature published between 1985 and 2010, such as key texts, empirical research, public policies, training manuals and community information sheets on heat waves. DISCUSSION: Current clinical practice and clinical impact of heatwaves on those @entity1 with comorbidity is explored. This includes the physiological components of heat stress, heat regulation, and the impact of @entity167 and other drugs; and, ramifications and professional practice issues for those with mental health conditions and those requiring mental health medications. IMPLICATIONS FOR NURSING: Client education covering modification of the environment and the use of client heat safety action plans. Secure, accessible stores of prescribed medication are recommended and emergency substance withdrawal kits could be made available. CONCLUSION: All nurses have a responsibility to increase the capability and resilience of their clients to manage their chronic health needs during a heatwave. At these times nurses need to give extra monitoring and assistance when clients lack the capacity or resources to protect themselves.

title: Heatwaves and their impact on XXXX with @entity167 , drug and mental health conditions: a discussion paper on clinical practice considerations.

answer: @entity1 :: (9606,Species) :: ['people']


abstract: BACKGROUND: Previous studies on the effect of the @entity1216 and @entity4745 -containing varnish (Cervitec((R))) have consistently shown a reduction in @entity6586 , while the data on the caries-inhibiting effect are conflicting. AIM: To measure the effect of a @entity1216 - and @entity4745 -containing varnish (Cervitec) on approximal caries in a low caries population. MATERIAL: Eighty-five schoolchildren, 13 years of age, entered the study after being selected on the basis of bitewing radiographs. @entity1 with at least one approximal lesion were included after informed consent. METHODS: The study was carried out as a double-blind, randomized controlled trial according to a split-mouth design using Cervitec on one side and a placebo varnish on the other side. All approximal surfaces between molars and premolars were treated every 3rd month. After 2 years new bitewing radiographs were taken. A total of 73 @entity1 completed the 2-year study. RESULTS: Neither the difference in number of new lesions between the Cervitec-treated and the placebo-treated side (d: -0.21; 95% CI: -0.57; 0.16) nor the mean difference in number of already existing lesions that progressed (d: -0.01; 95% CI: -0.33; 0.30) were statistically significant (paired t test; p > 0.05). CONCLUSION: The results of our study do not indicate an effect of Cervitec on initiation or progression of approximal caries in a population with a low DMFS.

title: Effect of a varnish containing XXXX and @entity4745 (Cervitec) on approximal caries in 13- to 16-year-old schoolchildren in a low caries area.

entities_list: @entity6586 :: ('1309', 'Species') :: ['STREPTOCOCCUS MUTANS']

entities_list: @entity1216 :: ('MESH:D002710', 'Chemical') :: ['chlorhexidine']

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

answer: @entity1216 :: (MESH:D002710,Chemical) :: ['chlorhexidine']


abstract: BACKGROUND: Previous studies on the effect of the @entity1216 and @entity4745 -containing varnish (Cervitec((R))) have consistently shown a reduction in @entity6586 , while the data on the caries-inhibiting effect are conflicting. AIM: To measure the effect of a @entity1216 - and @entity4745 -containing varnish (Cervitec) on approximal caries in a low caries population. MATERIAL: Eighty-five schoolchildren, 13 years of age, entered the study after being selected on the basis of bitewing radiographs. @entity1 with at least one approximal lesion were included after informed consent. METHODS: The study was carried out as a double-blind, randomized controlled trial according to a split-mouth design using Cervitec on one side and a placebo varnish on the other side. All approximal surfaces between molars and premolars were treated every 3rd month. After 2 years new bitewing radiographs were taken. A total of 73 @entity1 completed the 2-year study. RESULTS: Neither the difference in number of new lesions between the Cervitec-treated and the placebo-treated side (d: -0.21; 95% CI: -0.57; 0.16) nor the mean difference in number of already existing lesions that progressed (d: -0.01; 95% CI: -0.33; 0.30) were statistically significant (paired t test; p > 0.05). CONCLUSION: The results of our study do not indicate an effect of Cervitec on initiation or progression of approximal caries in a population with a low DMFS.

title: Effect of a varnish containing @entity1216 and XXXX (Cervitec) on approximal caries in 13- to 16-year-old schoolchildren in a low caries area.

answer: @entity4745 :: (MESH:D013943,Chemical) :: ['thymol']


abstract: @entity65 factor management by French vs US primary care physicians was studied. A survey was conducted that found that French physicians spend >20 minutes while US physicians spend five to 10 minutes (P<.001) addressing cardiovascular risk with @entity1 . Fifty-three percent of French (vs 33% of US) physicians focus more on lifestyle modification and less on medication management (P<.0001). Sixty-nine percent of French physicians spend 0% to 20% of their time on administration while 65% of US physicians spend 10% to 30% (P=.0028). Fifty-one percent of French physicians see @entity1 in one to three months for follow-up, while 51% of US physicians see @entity1 in three to six months (P<.0001). Eighty-seven percent of French (vs 39% of US) physicians have guidelines available in the examination room either frequently or very frequently. US physicians report disparities in care more frequently than do French physicians (P<.0001). Forty-nine percent of French (vs 10% of US) physicians believe that they have relative freedom to practice medicine (P<.001). US physicians report greater administrative efforts, frustration, and disparities in their practice. French physicians focus more of their efforts on lifestyle management and see their @entity1 more frequently and for a longer visit time.

title: Physician XXXX risk factor management: practices in France vs the United States.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['Cardiovascular risk']

answer: @entity65 :: (MESH:D002318,Disease) :: ['cardiovascular disease']


abstract: The ultrasonic diagnosis of @entity3359 can give a more accurate information than clinical data alone. In diagnosis of the parotid gland diseases, it is necessary to differentiate @entity5 from other diseases. When a @entity5 is suspected, its presence should be confirmed, and determined if it is solitary, multiple, unilateral or bilateral, intra or extraglandular, and benign or malignant. In the period of May 1998 to January 2001 ultrasound examinations were performed in 354 @entity1 , FNAB with ultrasound control were performed in 152 @entity1 with a mean age of 49.7 years. The ultrasound and cytologic findings were correlated with surgical and histologic findings. Results indicate that in @entity1 with solid mass of the salivary gland, ultrasound examination confirmed the finding of @entity5 in all @entity1 (100%). In non-solid diseases of salivary glands the diagnostic accuracy was slightly lower. The use of ultrasound techniques in the study of salivary gland pathology is well justified, due to its capacity to provide high resolution and improving clinical diagnosis. FNAB is a simple quick, accurate and virtually complications free investigative modality. The data on its ability to distinguish between lesions requiring surgery or not are encouraging.

title: Fine needle aspiration biopsy in a diagnostic workup algorithm of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['clearly tumors', 'tumor', 'salivary gland tumor']

entities_list: @entity3359 :: ('MESH:D012466', 'Disease') :: ['salivary gland diseases']

answer: @entity5 :: (MESH:D009369,Disease) :: ['salivary gland tumors']


abstract: OBJECTIVES: To determine the incremental risk of diagnosis of clinically insignificant @entity263 with serial prostate biopsies. METHODS: We reviewed our institutional radical prostatectomy (RP) database comprising 2411 consecutive @entity1 undergoing RP. We then stratified @entity1 by the prostate biopsy on which their @entity5 was diagnosed and correlated biopsy number with the risk of clinically insignificant disease and adverse pathology at radical prostatectomy. RESULTS: A total of 1867 (77.4%), 281 (11.9%), and 175 (7.3%) @entity1 underwent 1, 2, and 3 or more prostate biopsies, respectively, before RP. Increasing number of prostate biopsies was associated with increasing prostate volume (P <.01), @entity1486 (P <.01), associated @entity5436 (P <.01), and increased likelihood of clinical Gleason 6 or less disease (P <.01). On pathologic analysis, increasing number of prostate biopsies was associated with increased risk of low-volume (P <.01), organ-confined (P <.01) disease. The risk of clinically insignificant disease was found to be 31.1%, 43.8%, and 46.8% in those undergoing 1, 2, and 3+ prostate biopsies, respectively. Conversely, the risk of adverse pathology was found to be 64.6%, 53.0%, and 52.0% in those undergoing 1, 2, and 3+ prostate biopsies, respectively. CONCLUSIONS: @entity1 undergoing multiple prostate biopsies before RP are more likely to harbor clinically insignificant @entity263 than those who only undergo 1 biopsy before resection. Nonetheless, the risk of adverse pathology in @entity1 undergoing serial biopsies remains significant. The increased risk of @entity263 overdiagnosis and overtreatment must be balanced with the continued risk of clinically significant disease when counseling @entity1 regarding serial biopsies.

title: Repeat prostate biopsy and the incremental risk of clinically insignificant XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']

entities_list: @entity5436 :: ('MESH:D019048', 'Disease') :: ['prostate intraepithelial neoplasia']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: BACKGROUND: Primary @entity43 is an extremely rare @entity11090 with fewer than 30 documented cases worldwide. Immunohistochemically, @entity43 are characterized by the expression of alpha-smooth muscle actin (alpha-SMA). Until recently, no report investigated the role of @entity588 expression in primary @entity43 . We report the management and an immunohistochemical analysis of @entity588 in a @entity1 with primary @entity43 . CASE REPORT: The @entity1 , a 71-year-old @entity1 , presented with a history of lower @entity490 and a palpable mass in the lower abdomen. Surgical exploration revealed a large left adnexal mass that had developed from the left ovary and infiltrated one part of the omentum adherent to the left adnexa. Microscopically the left @entity5 consisted of spindle cells arranged in smooth-muscle bundles and fascicles. The @entity5 was characterized by high cellularity and nuclear polymorphism, as well as patchy @entity39 and large areas of @entity548 . Mitotic activity exceeded 5 mitoses per 10 high-power fields with many atypical mitoses. The @entity5 appeared encapsulated, and the capsule was partially disrupted by @entity5 cells. Immunohistochemically, the @entity5 showed a strong staining reaction for muscle actin, alpha-SMA and @entity3508 , and also a weak reaction for @entity2277 . Strong staining of @entity588 was detected, with more than 80% of @entity242 cells positive. According to the FIGO staging system for @entity43 , the @entity5 was classified as a primary @entity43 stage III C, and the @entity1 was treated with an adjuvant chemotherapy regimen consisting of @entity900 and @entity1260 . Two days after the third cycle of @entity900 /ifosfamid she developed an apoplexy spontaneously and chemotherapy was therefore discontinued. The @entity1 remained without evidence of disease until she died as a result of intercurrent @entity55 14 months after initial surgery. CONCLUSIONS: Beside the routine histological and immunohistochemical characteristics of primary @entity43 , strong staining for @entity588 was detected. In order to understand more about the nature and the behaviour of this highly malignant @entity5 and to be able to improve the treatment, the prognostic value of @entity588 has to be investigated in additional studies.

title: @entity588 expression in a primary XXXX : a case report.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian leiomyosarcomas', 'ovarian cancer', 'leiomyosarcoma of the ovary', 'ovarian leiomyosarcoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'adnexal tumor', 'neoplasm']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity3508 :: ('2026', 'Gene') :: ['neuron-specific enolase']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity11090 :: ('MESH:D019042', 'Disease') :: ['malignant smooth-muscle neoplasm']

entities_list: @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']

answer: @entity43 :: (MESH:D010051,Disease) :: ['leiomyosarcoma of the ovary']


abstract: BACKGROUND: Primary @entity43 is an extremely rare @entity11090 with fewer than 30 documented cases worldwide. Immunohistochemically, @entity43 are characterized by the expression of alpha-smooth muscle actin (alpha-SMA). Until recently, no report investigated the role of @entity588 expression in primary @entity43 . We report the management and an immunohistochemical analysis of @entity588 in a @entity1 with primary @entity43 . CASE REPORT: The @entity1 , a 71-year-old @entity1 , presented with a history of lower @entity490 and a palpable mass in the lower abdomen. Surgical exploration revealed a large left adnexal mass that had developed from the left ovary and infiltrated one part of the omentum adherent to the left adnexa. Microscopically the left @entity5 consisted of spindle cells arranged in smooth-muscle bundles and fascicles. The @entity5 was characterized by high cellularity and nuclear polymorphism, as well as patchy @entity39 and large areas of @entity548 . Mitotic activity exceeded 5 mitoses per 10 high-power fields with many atypical mitoses. The @entity5 appeared encapsulated, and the capsule was partially disrupted by @entity5 cells. Immunohistochemically, the @entity5 showed a strong staining reaction for muscle actin, alpha-SMA and @entity3508 , and also a weak reaction for @entity2277 . Strong staining of @entity588 was detected, with more than 80% of @entity242 cells positive. According to the FIGO staging system for @entity43 , the @entity5 was classified as a primary @entity43 stage III C, and the @entity1 was treated with an adjuvant chemotherapy regimen consisting of @entity900 and @entity1260 . Two days after the third cycle of @entity900 /ifosfamid she developed an apoplexy spontaneously and chemotherapy was therefore discontinued. The @entity1 remained without evidence of disease until she died as a result of intercurrent @entity55 14 months after initial surgery. CONCLUSIONS: Beside the routine histological and immunohistochemical characteristics of primary @entity43 , strong staining for @entity588 was detected. In order to understand more about the nature and the behaviour of this highly malignant @entity5 and to be able to improve the treatment, the prognostic value of @entity588 has to be investigated in additional studies.

title: XXXX expression in a primary @entity43 : a case report.

answer: @entity588 :: (596,Gene) :: ['Bcl-2']


abstract: BACKGROUND AND AIMS: Nearly 25% of normal weight individuals display abnormal metabolic profiles associated with @entity28 . As a wide range in body fat percentage (%BF) exists for BMI-defined normal weight individuals, we investigated whether elevated %BF (determined using DXA) was associated with @entity10204 among 977 normal weight subjects (192 @entity1 , 785 @entity1 ) from the Canadian province of Newfoundland and Labrador. METHODS AND RESULTS: BMI and %BF were measured after a 12-h fasting period. @entity854 considered included elevated @entity412 , @entity413 and hsCRP levels, decreased HDL @entity165 , insulin resistance, and @entity101 . Subjects were classified as metabolically healthy (0 or 1 @entity854 ) or abnormal (>= 2 @entity854 ) and divided into sex-specific %BF tertiles as follows: low ( <=15.2% @entity1 ,  <=29.7% @entity1 ), medium (15.3-20.7%% @entity1 , 29.8-34.9%% @entity1 ) and high (>= 20.8% @entity1 , >= 35.0% @entity1 ). The prevalence of the metabolically abnormal phenotype was higher among medium and high %BF subjects (12.0% and 19.5%, respectively) compared to the low group (7.4%; p  <  0.05). Furthermore, the odds of being metabolically abnormal were 1.61 (95% CI 0.94-2.77) for medium %BF subjects compared to the low group and nearly tripled for high %BF subjects (OR 2.73, 95% CI 1.63-4.86). ORs remained significant after further adjustment for waist circumference. CONCLUSION: Our findings indicate that those with elevated %BF are at increased risk of developing @entity66 despite having a normal BMI. Future development of adequate screening tools to identify these individuals is crucial to the prevention of @entity28 .

title: Body fat percentage is associated with XXXX in BMI-defined normal weight subjects.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity-associated disease', 'obesity']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cardiometabolic disease']

entities_list: @entity10204 :: ('MESH:D021081', 'Disease') :: ['cardiometabolic dysregulation']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['cardiometabolic abnormality', 'cardiometabolic abnormalities', 'Cardiometabolic abnormalities']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity10204 :: (MESH:D021081,Disease) :: ['cardiometabolic dysregulation']


abstract: OBJECTIVE: Low-frequency repetitive transcranial magnetic stimulation (rTMS) is emerging as a therapeutic tool in @entity302 . In recent years, several open-label trials have shown an encouraging reduction in @entity410 frequency in @entity1 with @entity302 . However, the data from controlled trials are mixed with respect to antiepileptic rTMS efficacy, and the field would benefit from further carefully controlled trials. Prior to initiating new trials, it is important assess the magnitude of the placebo effect of presently used sham rTMS methods. METHODS: We systematically analyzed individual subject data from three placebo-controlled trials and measured the placebo effect at follow-up intervals of 2, 4, and 8 weeks after sham rTMS treatment. Given the relatively small subgroup sample size, placebo condition data were pooled for analysis. RESULTS: Three methods for sham rTMS were employed in the reviewed studies: (1) coil positioning orthogonal to the scalp, (2) a spring-loaded sham coil, and (3) a double active-sham coil. The placebo response overall was consistently low across follow-up intervals, both for median change in @entity410 frequency (Kruskal-Wallis, P>0.4, df=2) and for responder (defined as >=  50% @entity410 frequency reduction) rate (Fisher's exact rest, P>0.9, df=2). The aggregate effect of the placebo condition was a 0-2% median @entity410 reduction rate and a responder rate of 16-20%. CONCLUSION: We anticipate that these data will contribute to future power analysis as well as selection and design of sham rTMS methods for controlled rTMS trials.

title: An estimate of placebo effect of repetitive transcranial magnetic stimulation in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: Autogenous fat augmentation for @entity1887 has been used previously in @entity1 treatment regimes. However, relatively little information is currently available regarding the effectiveness of fat injection for @entity1 with vocal fold @entity194 who have complete glottal closure (VFACGC). This paper compares, in retrospect, the efficiency of fat injection after surgery in @entity1 with VFACGC (n=21). The perceptual acoustic and phonatory functions and videolaryngostroboscopic data were evaluated before and after fat augmentation was performed on 13 @entity1 . Mean follow-up time was 9.5 months. Fifteen @entity1 displayed excellent results, four experienced post-procedure failure, and two were unavailable for follow-up analysis. The majority of VFACGC @entity1 (71%) also suffered from muscular @entity7364 (MTD) preoperatively. The procedure also resolved the MTD in half (54%) of the @entity1 in this study. Perceptual rating showed significant improvement in grade, roughness and breathiness (P<0.05). The videolaryngostroboscopic rating showed significant improvements in vocal fold edge linearity (P<0.01), vocal fold vibration amplitude and mucosal wave excursion (P<0.05). VFACGC is commonly misdiagnosed as MTD and is, therefore, unresponsive to speech therapy that is targeted to the latter. Fat injection is an effective autogenous implant and should be considered as an option in the treatment of @entity1 with VFACGC. Although fat re-absorption was identified as a problem, repeating the procedure could be considered to minimize the effect of such.

title: Autogenous fat injection for vocal fold XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['glottic insufficiency']

entities_list: @entity7364 :: ('MESH:D055154', 'Disease') :: ['tension dysphonia']

answer: @entity194 :: (MESH:D001284,Disease) :: ['atrophy']


abstract: UNASSIGNED: Wide surgical resection or a marginal/incomplete resection followed by full-course radiation therapy is the current standard of care for @entity235 soft tissue @entity242 . The purpose of this retrospective, descriptive, bi-institutional study was to determine the effectiveness and @entity137 of a hypofractionated 5  *  6 Gy protocol on macroscopic @entity235 soft tissue @entity242 in terms of progression-free interval (PFI) and @entity1349 ( @entity1349 ), and to identify prognostic factors for @entity1 outcome. @entity235 with @entity242 irradiated with 5 * 6 Gy were eligible for the study. @entity1349 were compared with respect to different @entity5 and @entity1 characteristics by the Kaplan-Meier method and multivariable Cox regression analysis. Fifty @entity235 with macroscopic disease were included. All @entity235 received the same radiation therapy protocol; part of the group (n = 20) received postradiation metronomic chemotherapy. Median PFI for all cases was 419 days (95% confidence interval (CI): 287-551) and median @entity1349 was 513 days (95% CI: 368-658). @entity235 with @entity5 on the limbs had significantly longer PFI and @entity1349 , compared with head or trunk. Increasing @entity5 burden decreased @entity1349 . The addition of metronomic chemotherapy yielded a significantly longer @entity1349 (757 days (95% CI: 570-944) compared with @entity235 that did not receive systemic treatment (286 days (95% CI: 0-518), (P = 0.023)), but did not influence progression-free interval. @entity137 was low throughout all treatments. The 5 * 6 Gy radiation therapy protocol was well tolerated and provided long PFI and @entity1349 in @entity235 with @entity242 .

title: HYPOFRACTIONATED RADIOTHERAPY FOR MACROSCOPIC XXXX SOFT TISSUE SARCOMA: A RETROSPECTIVE STUDY OF 50 CASES TREATED WITH A 5 * 6 GY PROTOCOL WITH OR WITHOUT METRONOMIC CHEMOTHERAPY.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'macroscopic soft tissue sarcoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'Progression-free interval and OS', 'overall survival']

answer: @entity235 :: (9615,Species) :: ['CANINE']


abstract: UNASSIGNED: Oral sedation for pre-cooperative and anxious pediatric @entity1 is an important tool for the pediatric dentist. Few studies have examined the sedation regimen of @entity6882 and @entity5774 . OBJECTIVES: The primary goal of this study was to evaluate the overall safety and effectiveness of the @entity6882 / @entity5774 drug combination. Secondary goals included detecting potential factors that alter sedation effectiveness. STUDY DESIGN: Two hundred and forty eight electronic health records of pediatric @entity1 (131 females, 117 males) who received @entity6882 / @entity5774 sedations in a university setting were evaluated. Pediatric dental residents rated each case according to the Frankl behavioral scale and for effectiveness. Numerous factors were analyzed to evaluate their significance on overall effectiveness. Factors examined included age at time of treatment, gender, ASA status, Frankl score at various points during treatment, sextant of treatment, operator experience, dosage, use of @entity3810 , and any complications encountered during treatment, both major and minor. RESULTS: Over 81% of sedations were considered effective or very effective. Statistically significant findings included age of @entity1 , pre-sedation behavior, and willingness to take the medication. Less than 5% of sedations were aborted due to behavior. Only one major complication was found, which was not related to the sedation. CONCLUSIONS: @entity6882 combined with @entity5774 is a safe and effective sedation regimen for uncooperative or pre-cooperative @entity1 during dental treatment.

title: A Retrospective Study of 248 Pediatric Oral Sedations Utilizing the Combination of XXXX and @entity5774 for Dental Treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity6882 :: ('MESH:D008614', 'Chemical') :: ['Meperidine', 'meperidine']

entities_list: @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide']

entities_list: @entity5774 :: ('MESH:D006919', 'Chemical') :: ['hydroxyzine']

answer: @entity6882 :: (MESH:D008614,Chemical) :: ['Meperidine']


abstract: UNASSIGNED: Oral sedation for pre-cooperative and anxious pediatric @entity1 is an important tool for the pediatric dentist. Few studies have examined the sedation regimen of @entity6882 and @entity5774 . OBJECTIVES: The primary goal of this study was to evaluate the overall safety and effectiveness of the @entity6882 / @entity5774 drug combination. Secondary goals included detecting potential factors that alter sedation effectiveness. STUDY DESIGN: Two hundred and forty eight electronic health records of pediatric @entity1 (131 females, 117 males) who received @entity6882 / @entity5774 sedations in a university setting were evaluated. Pediatric dental residents rated each case according to the Frankl behavioral scale and for effectiveness. Numerous factors were analyzed to evaluate their significance on overall effectiveness. Factors examined included age at time of treatment, gender, ASA status, Frankl score at various points during treatment, sextant of treatment, operator experience, dosage, use of @entity3810 , and any complications encountered during treatment, both major and minor. RESULTS: Over 81% of sedations were considered effective or very effective. Statistically significant findings included age of @entity1 , pre-sedation behavior, and willingness to take the medication. Less than 5% of sedations were aborted due to behavior. Only one major complication was found, which was not related to the sedation. CONCLUSIONS: @entity6882 combined with @entity5774 is a safe and effective sedation regimen for uncooperative or pre-cooperative @entity1 during dental treatment.

title: A Retrospective Study of 248 Pediatric Oral Sedations Utilizing the Combination of @entity6882 and XXXX for Dental Treatment.

answer: @entity5774 :: (MESH:D006919,Chemical) :: ['Hydroxyzine']


abstract: The purpose of this study was to determine whether (1) there is a menstrual phase effect on blood pressure (BP) and @entity299 ( @entity299 ), and (2) the effects of physical effort, posture, or moods on BP and @entity299 is mediated by the menstrual phase. Twelve normotensive @entity1 , aged between 28 and 50, with normal menstrual cycles were studied. BP was measured at 30- to 60-min intervals during a 24-hr period using an ambulatory BP monitor on Days 1, 8, 15, and 22 of the menstrual cycle. @entity1 were asked to report their posture, physical effort, and mood ("annoyed," "tense," and "happy") on 5-point Likert-type scales each time the ambulatory BP monitor took measurements. Systolic BP (SBP) was lower on Day 8 of the cycle. @entity551 were lower on Days 1 and 8. Daytime SBP was affected by the time of the day and posture, but not by moods, whereas daytime DBP was affected by posture and levels of tenseness. The level of physical effort only affected @entity299 , not BP. The average daytime physical and emotional variables had little influence over the average daytime BP. In 12 normotensive @entity1 with a normal menstrual cycle, SBP was lower during the follicular phase and DBP and @entity299 were lower during the follicular phase and menstruation even after controlling the effects of other factors. Physical activity or moods had only momentary effects on BP or @entity299 . A cross-validation statistical method used is suggested to study how individuals are affected by various factors. With the use of this method, the inclusion of menstrual phase in the model improved the prediction of SBP for 5 out of the 12 @entity1 studied.

title: Effects of daily activities on ambulatory blood pressure during menstrual cycle in normotensive XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Participants']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['Diastolic BP (DBP) and HR']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart rate', 'HR']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: Disruption of the ureter is very rarely caused by a @entity130 , only 12 cases having been reported in Japan. A 20-year-old male suffered from a blunt @entity1661 in a traffic accident. Although his urinalysis showed no abnormalities, a dull @entity158 in the left flank region persisted for over a week after the injury. Under the suspicion of @entity8 , an excretory urogram (DIP) was conducted. The form of renal pelvis and calyces was almost normal on both sides, while extravasation of contrast medium was recognized around the lower pole of the left kidney. The retrograde pyelogram of the left side revealed that catheterization was possible up to 30 cm from the ureteral orifice, but the injected medium leaked into the retroperitoneal space making it impossible to visualize the left renal pelvis and calyces. An operation was performed under the diagnosis of left @entity1901 on the 19th day after @entity130 . The left ureter was completely disrupted 2 cm distally from the ureteropelvic junction. An end to end @entity254 of the ureter was done with 6-0 Dexon sutures. The DIP taken on the 25th day after the operation showed slight dilatation of the left pelvis and calyces. However, the renogram conducted 6 months after the operation demonstrated a normal pattern on both sides.

title: [A case of XXXX caused by a traffic accident].

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal or ureteral injury']

entities_list: @entity1901 :: ('MESH:D014515', 'Disease') :: ['ureteral injury']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal trauma']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['blunt trauma', 'trauma']

answer: @entity1901 :: (MESH:D014515,Disease) :: ['ureteral disruption']


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2804 ( @entity2974 ) has been used for treating acne. The ability of @entity2974 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity3785 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity2974 25% peels with those of @entity3785 30% in @entity1 with @entity5477 . MATERIALS AND METHODS: Twenty @entity1 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity2974 was applied to the right half of the face and 30% @entity3785 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity3785 peeling (95%) versus (85%) with @entity2974 . Total comedones improvement was more frequent with @entity2974 peeling (80%) versus (70%) with @entity3785 . Improvement of inflammatory lesions was more frequent among the side treated with @entity3785 (85%) versus (80%) with @entity2974 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2804 is more superior in treating @entity75 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: @entity2804 Versus @entity3785 in the Treatment of @entity5477 in Dark-Skinned XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5477 :: ('MESH:D000152', 'Disease') :: ['acne vulgaris']

entities_list: @entity3785 :: ('MESH:D020156', 'Chemical') :: ['salicylic acid', 'Salicylic acid']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['comedonal lesions']

entities_list: @entity2804 :: ('MESH:D014238', 'Chemical') :: ['Trichloroacetic acid']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2804 ( @entity2974 ) has been used for treating acne. The ability of @entity2974 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity3785 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity2974 25% peels with those of @entity3785 30% in @entity1 with @entity5477 . MATERIALS AND METHODS: Twenty @entity1 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity2974 was applied to the right half of the face and 30% @entity3785 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity3785 peeling (95%) versus (85%) with @entity2974 . Total comedones improvement was more frequent with @entity2974 peeling (80%) versus (70%) with @entity3785 . Improvement of inflammatory lesions was more frequent among the side treated with @entity3785 (85%) versus (80%) with @entity2974 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2804 is more superior in treating @entity75 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: @entity2804 Versus XXXX in the Treatment of @entity5477 in Dark-Skinned @entity1 .

answer: @entity3785 :: (MESH:D020156,Chemical) :: ['Salicylic Acid']


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2804 ( @entity2974 ) has been used for treating acne. The ability of @entity2974 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity3785 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity2974 25% peels with those of @entity3785 30% in @entity1 with @entity5477 . MATERIALS AND METHODS: Twenty @entity1 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity2974 was applied to the right half of the face and 30% @entity3785 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity3785 peeling (95%) versus (85%) with @entity2974 . Total comedones improvement was more frequent with @entity2974 peeling (80%) versus (70%) with @entity3785 . Improvement of inflammatory lesions was more frequent among the side treated with @entity3785 (85%) versus (80%) with @entity2974 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2804 is more superior in treating @entity75 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: XXXX Versus @entity3785 in the Treatment of @entity5477 in Dark-Skinned @entity1 .

answer: @entity2804 :: (MESH:D014238,Chemical) :: ['Trichloroacetic Acid']


abstract: BACKGROUND: Treatment options for acne include chemical peeling. @entity2804 ( @entity2974 ) has been used for treating acne. The ability of @entity2974 to diminish corneocyte cohesion and keratinocyte plugging addresses this mode of treatment. @entity3785 is an excellent keratolytic agent. It is believed to function through solubilization of intercellular cement, thereby reducing corneocyte adhesion. OBJECTIVE: Comparing the therapeutic efficacy of @entity2974 25% peels with those of @entity3785 30% in @entity1 with @entity5477 . MATERIALS AND METHODS: Twenty @entity1 , Fitzpatrick skin Types III to V with facial acne, were enrolled. Twenty-five percent of @entity2974 was applied to the right half of the face and 30% @entity3785 to the left half at 2-week interval for 2 months. RESULTS: Total improvement was more frequent with @entity3785 peeling (95%) versus (85%) with @entity2974 . Total comedones improvement was more frequent with @entity2974 peeling (80%) versus (70%) with @entity3785 . Improvement of inflammatory lesions was more frequent among the side treated with @entity3785 (85%) versus (80%) with @entity2974 peeling. However, the results did not reach the statistical significance level. CONCLUSIONS: @entity2804 is more superior in treating @entity75 , whereas salicylic is more superior in treating inflammatory lesions, without significant different between their results.

title: @entity2804 Versus @entity3785 in the Treatment of XXXX in Dark-Skinned @entity1 .

answer: @entity5477 :: (MESH:D000152,Disease) :: ['Acne Vulgaris']


abstract: BACKGROUND: Spontaneous @entity1779 ( @entity1779 ) is a devastating @entity64 subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of @entity1476 and @entity1552 to @entity1779 ( @entity1779 ) susceptibility and @entity1410 size. METHODS: Associations were tested by logistic regression and @entity3628 ( @entity3628 ) where appropriate, adjusting with covariables of age, sex, @entity101 , @entity6 , smoking, and @entity285 consumption. Association analyses were performed first by stratification of genders and then by the age of 65 years old (y/o). Elder population was defined as subjects who were older than 65 y/o. RESULTS: There were 396 @entity1779 @entity1 and 376 control subjects in this study. In the elder group, @entity72510 @entity11414 variant in @entity1552 was associated with @entity1779 in male and overall @entity1 (OR = 3.49, 95% CI 1.45 to 8.40, P = 0.005 and OR = 2.45, 95% CI 1.37 to 4.38, P = 0.003, respectively) in additive genetic model. In recessive genetic model, @entity37057 TT genotype in @entity1476 was correlated to @entity1779 in male @entity1 and overall elder group (OR = 7.30, 95% CI 1.3 to 40, P = 0.02 and OR = 2.91, 95% CI 1.02 to 8.31, P = 0.046, respectively), and @entity72511 AA genotype in @entity1552 was associated with @entity1779 in female @entity1 (OR = 0.29, 95% CI 0.1 to 0.84, P = 0.02). In younger male and overall younger @entity1 , @entity1779 @entity1 who had @entity548 had significantly lower frequency of AA genotypes in @entity72511 than those with @entity548 (OR = 0.36, 95% CI 0.17 to 0.75, P = 0.006 and OR = 0.43, 95% CI 0.22 to 0.84, P = 0.014, respectively). @entity548 size increased by 9.7 (95% CI 2.1 to 43, P = 0.004) cm3 per minor allele (A) of the @entity72510 variant in the elder female @entity1 and increased by 4.3 (95% CI 1.4 to 12.9, P = 0.009) cm3 per minor allele (A) in all elder @entity1 . In younger @entity1 , the @entity548 size decreased by 3.3 (95% CI 1.2 to 9.5, P = 0.03) cm3 per minor allele of the s7503726 variant in the female @entity1 . CONCLUSIONS: This study showed a significant association between the variants of @entity1476 and @entity1552 promoters and @entity1779 susceptibility with significant age and gender differences. @entity548 location and size might be affected by @entity1552 promoter variants in the @entity1779 @entity1 .

title: Polymorphisms in the Promoters of the XXXX and @entity1552 Genes Are Associated with Spontaneous @entity1779 in the Taiwan Population.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'infratentorial hemorrhage', 'Hemorrhage', 'supratentorial hemorrhage']

entities_list: @entity3628 :: ('MESH:D004195', 'Disease') :: ['general linear models', 'GLM']

entities_list: @entity1779 :: ('MESH:D002543', 'Disease') :: ['SDICH', 'ICH', 'intracerebral hemorrhage', 'spontaneous deep ICH']

answer: @entity1476 :: (4313,Gene) :: ['MMP-2']


abstract: BACKGROUND: Spontaneous @entity1779 ( @entity1779 ) is a devastating @entity64 subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of @entity1476 and @entity1552 to @entity1779 ( @entity1779 ) susceptibility and @entity1410 size. METHODS: Associations were tested by logistic regression and @entity3628 ( @entity3628 ) where appropriate, adjusting with covariables of age, sex, @entity101 , @entity6 , smoking, and @entity285 consumption. Association analyses were performed first by stratification of genders and then by the age of 65 years old (y/o). Elder population was defined as subjects who were older than 65 y/o. RESULTS: There were 396 @entity1779 @entity1 and 376 control subjects in this study. In the elder group, @entity72510 @entity11414 variant in @entity1552 was associated with @entity1779 in male and overall @entity1 (OR = 3.49, 95% CI 1.45 to 8.40, P = 0.005 and OR = 2.45, 95% CI 1.37 to 4.38, P = 0.003, respectively) in additive genetic model. In recessive genetic model, @entity37057 TT genotype in @entity1476 was correlated to @entity1779 in male @entity1 and overall elder group (OR = 7.30, 95% CI 1.3 to 40, P = 0.02 and OR = 2.91, 95% CI 1.02 to 8.31, P = 0.046, respectively), and @entity72511 AA genotype in @entity1552 was associated with @entity1779 in female @entity1 (OR = 0.29, 95% CI 0.1 to 0.84, P = 0.02). In younger male and overall younger @entity1 , @entity1779 @entity1 who had @entity548 had significantly lower frequency of AA genotypes in @entity72511 than those with @entity548 (OR = 0.36, 95% CI 0.17 to 0.75, P = 0.006 and OR = 0.43, 95% CI 0.22 to 0.84, P = 0.014, respectively). @entity548 size increased by 9.7 (95% CI 2.1 to 43, P = 0.004) cm3 per minor allele (A) of the @entity72510 variant in the elder female @entity1 and increased by 4.3 (95% CI 1.4 to 12.9, P = 0.009) cm3 per minor allele (A) in all elder @entity1 . In younger @entity1 , the @entity548 size decreased by 3.3 (95% CI 1.2 to 9.5, P = 0.03) cm3 per minor allele of the s7503726 variant in the female @entity1 . CONCLUSIONS: This study showed a significant association between the variants of @entity1476 and @entity1552 promoters and @entity1779 susceptibility with significant age and gender differences. @entity548 location and size might be affected by @entity1552 promoter variants in the @entity1779 @entity1 .

title: Polymorphisms in the Promoters of the @entity1476 and XXXX Genes Are Associated with Spontaneous @entity1779 in the Taiwan Population.

answer: @entity1552 :: (7077,Gene) :: ['TIMP-2']


abstract: BACKGROUND: Spontaneous @entity1779 ( @entity1779 ) is a devastating @entity64 subtype. Matrix metalloproteinases (MMPs) function in the degradation of extracellular matrix and the activities of MMPs are modulated by their endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs). This study aimed to discuss relationship of @entity1476 and @entity1552 to @entity1779 ( @entity1779 ) susceptibility and @entity1410 size. METHODS: Associations were tested by logistic regression and @entity3628 ( @entity3628 ) where appropriate, adjusting with covariables of age, sex, @entity101 , @entity6 , smoking, and @entity285 consumption. Association analyses were performed first by stratification of genders and then by the age of 65 years old (y/o). Elder population was defined as subjects who were older than 65 y/o. RESULTS: There were 396 @entity1779 @entity1 and 376 control subjects in this study. In the elder group, @entity72510 @entity11414 variant in @entity1552 was associated with @entity1779 in male and overall @entity1 (OR = 3.49, 95% CI 1.45 to 8.40, P = 0.005 and OR = 2.45, 95% CI 1.37 to 4.38, P = 0.003, respectively) in additive genetic model. In recessive genetic model, @entity37057 TT genotype in @entity1476 was correlated to @entity1779 in male @entity1 and overall elder group (OR = 7.30, 95% CI 1.3 to 40, P = 0.02 and OR = 2.91, 95% CI 1.02 to 8.31, P = 0.046, respectively), and @entity72511 AA genotype in @entity1552 was associated with @entity1779 in female @entity1 (OR = 0.29, 95% CI 0.1 to 0.84, P = 0.02). In younger male and overall younger @entity1 , @entity1779 @entity1 who had @entity548 had significantly lower frequency of AA genotypes in @entity72511 than those with @entity548 (OR = 0.36, 95% CI 0.17 to 0.75, P = 0.006 and OR = 0.43, 95% CI 0.22 to 0.84, P = 0.014, respectively). @entity548 size increased by 9.7 (95% CI 2.1 to 43, P = 0.004) cm3 per minor allele (A) of the @entity72510 variant in the elder female @entity1 and increased by 4.3 (95% CI 1.4 to 12.9, P = 0.009) cm3 per minor allele (A) in all elder @entity1 . In younger @entity1 , the @entity548 size decreased by 3.3 (95% CI 1.2 to 9.5, P = 0.03) cm3 per minor allele of the s7503726 variant in the female @entity1 . CONCLUSIONS: This study showed a significant association between the variants of @entity1476 and @entity1552 promoters and @entity1779 susceptibility with significant age and gender differences. @entity548 location and size might be affected by @entity1552 promoter variants in the @entity1779 @entity1 .

title: Polymorphisms in the Promoters of the @entity1476 and @entity1552 Genes Are Associated with Spontaneous XXXX in the Taiwan Population.

answer: @entity1779 :: (MESH:D002543,Disease) :: ['Deep Intracerebral Hemorrhage']


abstract: UNASSIGNED: Background: There are not many studies investigating mental health of individuals with @entity717 . The aim of this study is to provide data on @entity308 and @entity148 in individuals with @entity717 . Method: In a cross-sectional study, we assessed @entity1 and @entity1 with @entity717 (18-65 years) with a standardized instrument with 2 divisions (division 1: variables "residence", "self-determination capabilities", "violence experiences", division 2: variables " @entity308 " and " @entity148 " with the @entity1 Health Questionaire-4). Univariate and bivariate analysis of the data was performed. Result: Out of a total of 59% @entity1 and 41% @entity1 , 44 participated in the study (response rate=45%). Overall, 20% (n=9) of the @entity1 had an increased PHQ-2 score. This can be used as an indicator for @entity308 . 18% (n=8) of the subject group indicated an increased @entity1840 score. This can be used as an indicator of @entity148 . Risk factors for @entity308 were "an increased level of disability" (RR=11,8), "living with parents" (RR=6, 7), "limited self-determination capabilities"(RR=6,2) and "fear of new situations" (RR=5:0). Violence experiences were a risk factor (RR=13,3) for @entity148 . Conclusion: In view of the special methodological challenges of this study, the target group is very small. Nevertheless, this is one of the first studies in Germany that reveals factors with an impact on the mental health of individuals with @entity717 . The association of experience of violence with @entity148 in individuals with @entity717 represents an important challenge for public health.

title: ["Mental Health in Adults with @entity717 . Protective and Risk Factors for XXXX and @entity148 " - a Cross-sectional Study].

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'Patient', 'men']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depression']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['intellectual disabilities', 'intellectual disability']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: UNASSIGNED: Background: There are not many studies investigating mental health of individuals with @entity717 . The aim of this study is to provide data on @entity308 and @entity148 in individuals with @entity717 . Method: In a cross-sectional study, we assessed @entity1 and @entity1 with @entity717 (18-65 years) with a standardized instrument with 2 divisions (division 1: variables "residence", "self-determination capabilities", "violence experiences", division 2: variables " @entity308 " and " @entity148 " with the @entity1 Health Questionaire-4). Univariate and bivariate analysis of the data was performed. Result: Out of a total of 59% @entity1 and 41% @entity1 , 44 participated in the study (response rate=45%). Overall, 20% (n=9) of the @entity1 had an increased PHQ-2 score. This can be used as an indicator for @entity308 . 18% (n=8) of the subject group indicated an increased @entity1840 score. This can be used as an indicator of @entity148 . Risk factors for @entity308 were "an increased level of disability" (RR=11,8), "living with parents" (RR=6, 7), "limited self-determination capabilities"(RR=6,2) and "fear of new situations" (RR=5:0). Violence experiences were a risk factor (RR=13,3) for @entity148 . Conclusion: In view of the special methodological challenges of this study, the target group is very small. Nevertheless, this is one of the first studies in Germany that reveals factors with an impact on the mental health of individuals with @entity717 . The association of experience of violence with @entity148 in individuals with @entity717 represents an important challenge for public health.

title: ["Mental Health in Adults with XXXX . Protective and Risk Factors for @entity308 and @entity148 " - a Cross-sectional Study].

answer: @entity717 :: (MESH:D009069,Disease) :: ['Intellectual Disabilities']


abstract: UNASSIGNED: Background: There are not many studies investigating mental health of individuals with @entity717 . The aim of this study is to provide data on @entity308 and @entity148 in individuals with @entity717 . Method: In a cross-sectional study, we assessed @entity1 and @entity1 with @entity717 (18-65 years) with a standardized instrument with 2 divisions (division 1: variables "residence", "self-determination capabilities", "violence experiences", division 2: variables " @entity308 " and " @entity148 " with the @entity1 Health Questionaire-4). Univariate and bivariate analysis of the data was performed. Result: Out of a total of 59% @entity1 and 41% @entity1 , 44 participated in the study (response rate=45%). Overall, 20% (n=9) of the @entity1 had an increased PHQ-2 score. This can be used as an indicator for @entity308 . 18% (n=8) of the subject group indicated an increased @entity1840 score. This can be used as an indicator of @entity148 . Risk factors for @entity308 were "an increased level of disability" (RR=11,8), "living with parents" (RR=6, 7), "limited self-determination capabilities"(RR=6,2) and "fear of new situations" (RR=5:0). Violence experiences were a risk factor (RR=13,3) for @entity148 . Conclusion: In view of the special methodological challenges of this study, the target group is very small. Nevertheless, this is one of the first studies in Germany that reveals factors with an impact on the mental health of individuals with @entity717 . The association of experience of violence with @entity148 in individuals with @entity717 represents an important challenge for public health.

title: ["Mental Health in Adults with @entity717 . Protective and Risk Factors for @entity308 and XXXX " - a Cross-sectional Study].

answer: @entity148 :: (MESH:D001008,Disease) :: ['Anxiety']


abstract: BACKGROUND: Early observational studies of endoscopic treatment and extracorporeal shock wave lithotripsy (ESWL) reported considerable or complete relief of @entity158 in 50%-80% of @entity1 with chronic @entity788 . There is no consensus on the measurement of @entity158 , making comparison of observational studies difficult, and little attention has been paid to the type and amount of analgesics used by @entity1 before and after decompressive treatment. METHODS: We performed a retrospective study of all @entity1 with chronic @entity788 and @entity1157 and receiving decompressing treatment between 1 November 1994 and 31 July 1999. Primary parameters were type and amount of analgesics used. RESULTS: Forty-nine @entity1 with chronic @entity788 and @entity1157 received stenting of the pancreatic duct (28 @entity1 ), ESWL (6 @entity1 ) or both (15 @entity1 ). After a median follow-up of 21 months, 35% of all @entity1 were @entity158 -free and a further 6% were not using analgesics. Seven @entity1 no longer needed opioids during follow-up, but five other @entity1 needed addition of opioids to treatment. The median opioid dose among opioid-dependent @entity1 rose slightly (9%). The median increase of weight after treatment was 1 kg per year. CONCLUSION: After decompressive treatment of @entity1 with chronic @entity788 and @entity1157 , we observed a small increase in weight and a small reduction in the number of opioid users. The changes may not be different from the natural course of the disease.

title: Stenting and extracorporeal shock wave lithotripsy in chronic XXXX .

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']

entities_list: @entity1157 :: ('MESH:D001649', 'Disease') :: ['large-duct disease']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatitis']