abstract: OBJECTIVE: Platelets contribute to @entity715 , and platelet @entity6071 ( @entity6071 ) are central in pathogen detection, potentially mediating infection-induced @entity432 . Using a large community-based cohort study, we sought to examine if platelets express all known TLR transcripts and analyze their association with cardiovascular risk factors. APPROACH AND RESULTS: mRNA levels for @entity6071 were measured in isolated platelets by high-throughput quantitative reverse transcriptase polymerase chain reaction in 1625 @entity1 (mean age, 66.6  9; 54% @entity1 ) of the Framingham Heart Study. We measured circulating inflammatory and thrombotic markers ( @entity1851 , @entity650 , @entity2842 , intracellular cell adhesion molecule 1, soluble @entity5 @entity39 factor-a receptor 1, and soluble @entity8729 ) and analyzed @entity6071 and their association with sex and cardiovascular risk factors by multivariable logit regression model adjusted for confounding factors. Platelets expressed all 10 TLR transcripts, and all @entity6071 were coexpressed. @entity1 had higher platelet TLR expression, which associated with different cardiovascular risk factors, compared with @entity1 . In @entity1 , @entity11709 , @entity6800 , @entity13976 , and @entity6438 were associated with body mass index and @entity20040 , @entity6438 , and @entity34617 were associated with total @entity165 to high-density lipoprotein ratio. In @entity1 , @entity11709 , @entity2938 , and @entity6800 were associated with lipid and @entity22879 with @entity101 treatment. Similarly, TLR expression in @entity1 was more commonly associated with circulating inflammatory markers (soluble @entity5 @entity39 factor-a receptor 1 and intracellular cell adhesion molecule 1), whereas in @entity1 , TLR expression was associated with soluble @entity8729 levels. CONCLUSIONS: We report the first study to demonstrate that platelets express all TLR transcripts using a large community-based observational cohort. These transcripts are more abundant in @entity1 and have distinct associations with cardiovascular risk and inflammatory biomarkers that vary by sex.

title: Sex differences in platelet XXXX and their association with cardiovascular risk factors.

entities_list: @entity6071 :: ('MESH:C562709', 'Disease') :: ['toll-like receptors', 'TLRs']

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'women', 'Women', 'participants']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity2842 :: ('6347', 'Gene') :: ['monocyte chemoattractant protein 1']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['vascular occlusion']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity6071 :: (MESH:C562709,Disease) :: ['toll-like receptors']


abstract: 61 @entity1 with constitutional delay of growth and maturation, aged 9-19 years and with a bone age (BA) lag of 1.3-5.5 years, were administered @entity6240 (0.05-0.24 mg/kg daily orally, relative dose increasing with age) to accelerate growth. The therapy was continuous and lasted 0.4-3.6 years. The findings are compared with 37 observation periods in a similar group of untreated @entity1 . Growth velocity increased in every treated @entity1 during the therapy, the mean first-year increment being 4.3 +/- 1.6 cm/year. For most @entity1 this brought about a decrease in the height difference from peers, and so afforded the psychosocial relief that was the objective of the therapy. After therapy the velocity decreased slightly in most @entity1 , from a mean of 9.1 +/- 1.4 to 7.1 +/- 3.3 cm/year. The effect of the intervention on final height was assessed by three relatively independent methods of prediction. These were found to be equally valid in the 15 control @entity1 for whom final heights are known. The effect appeared to vary individually, but on the average there appeared to be no loss of height potential. No individual @entity1 with initial BA greater than 10.5 years showed a substantial reduction in predicted final height.

title: Acceleration of delayed growth with XXXX .

entities_list: @entity6240 :: ('MESH:D005474', 'Chemical') :: ['fluoxymesterone']

answer: @entity6240 :: (MESH:D005474,Chemical) :: ['fluoxymesterone']


abstract: BACKGROUND: @entity6494 ( @entity6494 ) is caused by @entity2662 ). India is considered as a nonendemic region for @entity2662 . Recent upsurge of cases have been noted in southern parts of India. AIMS AND OBJECTIVES: The objective was to describe skin manifestations in various types of @entity6494 . MATERIALS AND METHODS: Clinical examination, blood investigations, skin biopsies, lymph node biopsies, and immunohistochemistry were performed in five @entity1 . Flow cytometry was performed in two cases. RESULTS: Serological testing was positive for @entity2662 in all @entity1 . All @entity1 presented with @entity272 . Rare presentations of molluscum contagiosum like papules, purpuric macules and plaques, hypopigmented macules and verrucous papules were seen. @entity281 occurred in two @entity1 . @entity3137 was seen in one @entity1 . Histological features include @entity706 with or without epidermotropism. Presence of epidermotropism did not correlate with the severity of disease. All @entity1 except one succumbed to illness within few months to 1 year period. CONCLUSIONS: @entity6494 manifest in myriad presentations and @entity272 are often the earliest manifestation. Cutaneous manifestations of @entity6494 vary from subtle hypopigmented macules to florid nodular lesions, and @entity2662 screening need to be carried out in all doubtful cases.

title: Multifaceted XXXX in India: a case series.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['dermal lymphoid infiltrate']

entities_list: @entity6494 :: ('MESH:D015459', 'Disease') :: ['Adult T-cell leukemia/lymphoma', 'ATL']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['Dermatophytic infections']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['skin lesions']

entities_list: @entity3137 :: ('MESH:D009059', 'Disease') :: ['Mucosal lesion']

entities_list: @entity2662 :: ('11908', 'Species') :: ['HTLV-1', 'human T-cell lymphotropic virus type-1 (HTLV-1']

answer: @entity6494 :: (MESH:D015459,Disease) :: ['adult T-cell leukemia/lymphoma']


abstract: Ms. V, a 10-year-old @entity1 was referred to @entity1 Psychiatry Department with complaints of @entity548 from eyes for last 3 months. Bleeding was spontaneous, recurrent, painless, and self-limited. History revealed significant Psychological stressors, Temperamental Difficulties and Conflicts with Mother. Mental status examination revealed @entity308 in Ms. V. During hospital stay, Ms. V developed repeated @entity548 episodes. The presence of hemoglobin is confirmed in the @entity548 sample. Hematologic investigations and computed tomography brain were normal. Ms. V was started on @entity3756 , @entity1169 , and @entity2053 . Both Ms. V and her Mother were psycho-educated about the nature of the illness. Ms. V was discharged and under follow-up. This case is reported for the rarity of presentation ( @entity548 from Eyes) of a childhood @entity308 .

title: The story of a @entity1 with weeping blood: XXXX with a rare presentation.

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['Propranolol']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity3756 :: ('MESH:D020280', 'Chemical') :: ['Sertraline']

entities_list: @entity2053 :: ('MESH:D002998', 'Chemical') :: ['Clonazepam']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Childhood depression']


abstract: Ms. V, a 10-year-old @entity1 was referred to @entity1 Psychiatry Department with complaints of @entity548 from eyes for last 3 months. Bleeding was spontaneous, recurrent, painless, and self-limited. History revealed significant Psychological stressors, Temperamental Difficulties and Conflicts with Mother. Mental status examination revealed @entity308 in Ms. V. During hospital stay, Ms. V developed repeated @entity548 episodes. The presence of hemoglobin is confirmed in the @entity548 sample. Hematologic investigations and computed tomography brain were normal. Ms. V was started on @entity3756 , @entity1169 , and @entity2053 . Both Ms. V and her Mother were psycho-educated about the nature of the illness. Ms. V was discharged and under follow-up. This case is reported for the rarity of presentation ( @entity548 from Eyes) of a childhood @entity308 .

title: The story of a XXXX with weeping blood: @entity308 with a rare presentation.

answer: @entity1 :: (9606,Species) :: ['girl']


abstract: OBJECTIVE: To discuss surgical approach selection and treatment strategy for preservation of the facial and lower cranial nerves' function in jugular foramen @entity808 surgery. METHODS: Retrospectively analyzed the clinical presentation, surgical approaches selection, facial and lower cranial nerves follow-up outcomes of 38 jugular foramen @entity808 , who received operations in the Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital affiliated to Shanghai Jiaotong University, School of Medicine during 2002 and 2012. RESULTS: A total of 38 @entity1 , including 18 @entity1 and 20 @entity1 , with ages ranged from 21 to 70 years (mean 45.3). @entity10 or @entity4048 in preoperative clinical presentation was present in 27 @entity1 (71.1%) and cervical mass in 9 @entity1 (23.7%). @entity129 , mainly the vagus nerve, were present in 21 @entity1 (55.3%). MRI finding: 19 @entity5 were intra- and extracranial, 10 were intracranial and 9 were extracranial. According to the @entity5 location and region, select the surgical approaches. 25 @entity1 used infratemporal fossa type A approach, 5 @entity1 used petrous occipital transsigmoid approach and 8 @entity1 used transcervial approach to remove @entity5 . The percentage of total resection was 92.1% (35/38). Adjunctive radiosurgery was used in the management of @entity41 in two @entity1 . All cases obtained ultimately @entity5 control. @entity1 were followed by MRI every 6 months for 1 year. Thereafter, they performed follow-up imaging every 1-2 years, and the @entity129 was analyzed and evaluated. They were followed up from 26-124 months (median follow-up was 62.3 months). During follow-up period, good facial function was obtained in 36 @entity1 (94.7%). All @entity1 had no @entity1282 . Complete compensation of lower @entity129 was achieved in all @entity1 . CONCLUSIONS: The preoperative estimation and location of @entity5 in nature is of great importance in the determination of proper surgical planning of jugular foramen @entity808 . @entity2103 and lower @entity129 can be preserved in maximal degree by proper surgical approaches and careful operative manipulation. Initial surgical resection followed by radiosurgery may be an effective option for some special @entity1 .

title: [Management of jugular foramen XXXX ].

entities_list: @entity808 :: ('MESH:D009442', 'Disease') :: ['Schwannomas', 'schwannomas']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['Cranial nerve impairments', 'cranial nerve function']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity2103 :: ('MESH:D005155', 'Disease') :: ['Facial nerve']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['swallowing disorder']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['Headache']

answer: @entity808 :: (MESH:D009442,Disease) :: ['Schwannomas']


abstract: BACKGROUND: Primary extended resection has been proposed as the initial treatment for @entity1 with @entity242 . This approach comprises an extended en-bloc resection of the directly infiltrated organs and adjacent uninvolved organs. The results of such radical surgery have yet to be validated. This retrospective study aims to investigate this practice in a contemporary series from a referral center in the UK. METHODS: We extracted data from consecutive @entity1 who underwent extended resectional surgery between 2009 and 2013, and investigated the type of resection performed, the effectiveness of extended surgery in providing negative microscopic margins, and the occurrence of post-surgical adverse events. RESULTS: A total of 69 @entity1 were included. Fifty-two @entity1 had a primary @entity5 (75.4  %), and in 55 @entity1 (79.7  %) the @entity5 was resected en bloc with adjacent organs or structures. Colonic resection (N  =  35, 50.7  %) and nephrectomy (N  =  28, 40.6  %) were the most frequently performed organ resections. Organs were infiltrated in 22 @entity1 (32  %), and there was no association between organ infiltration and @entity1 variables and staging characteristics. Negative microscopic margins were achieved in 88.6  % of @entity1 in this series. @entity260 occurred in 21 @entity1 (30  %) and a reoperation was required in ten cases (14.5  %). No independent predictors of morbidity were identified and no 30-day postoperative @entity204 occurred. CONCLUSIONS: Four-fifths of @entity1 in this series had organs removed in association with the @entity242 . This approach in a specialist sarcoma unit results in negative microscopic @entity5 margins in up to 90  % of cases and can be performed safely.

title: Outcomes Following Extended Surgery for XXXX : Results From a UK Referral Centre.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['retroperitoneal sarcoma']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative complications']

answer: @entity242 :: (MESH:D012509,Disease) :: ['Retroperitoneal Sarcomas']


abstract: BACKGROUND: Prenatal @entity3147 disrupts the pattern of maturation and development of the hippocampus and its neuroanatomy and increases inhibition of the granular cell layer of the fascia dentata. If local @entity1246 inter-neurons are partly responsible for inhibition of the hippocampus, it is reasonable to assume that there may be an increase in the @entity1246 cell population of prenatal @entity3147 @entity35 . OBJECTIVE: This experimental study was conducted to ascertain the effects of prenatal @entity3147 on the density of GABAergic interneurons at the cornus ammonis and fascia dentata in @entity35 . METHODS: Animals were investigated under two nutritional conditions: (i) prenatal @entity3147 group fed 6% protein, and (ii) well-nourished control group fed 25% protein. Using an antibody for @entity1246 , immunoreactive cells (GABAergic) were assessed in the rostral-caudal direction of the dorsal hippocampus at four levels. RESULTS: (i) In 30-day-old @entity35 with prenatal @entity3147 , the fascia dentata had an average of 27% more GABAergic cells than the control group; this higher amount was not detectable at 90 days. (ii) There was a significant 18% increase in GABAergic neurons at level 1 of the cornus ammonis at 90 days of age. CONCLUSIONS: There was an increase in the population of interneurons in the fascia dentata and cornus ammonis in prenatal @entity3147 @entity35 . We conclude that prenatal hypoprotein @entity3147 produces changes at 30 days in the fascia dentata. Results suggest that prenatal @entity3147 also produces a delay in the programmed chronology of @entity1246 interneurons. Finally, in cornus ammonis, at 90 days of age, prenatal @entity3147 showed an increase only at level 1; this effect may be evidenced in the long term, despite postnatal rehabilitation.

title: Prenatal Protein Malnutrition Affects the Density of GABAergic Interneurons During Hippocampus Development in XXXX .

entities_list: @entity1246 :: ('MESH:D005680', 'Chemical') :: ['gamma-aminobutyric acid']

entities_list: @entity3147 :: ('MESH:D044342', 'Disease') :: ['protein malnutrition', 'malnutrition']

answer: @entity35 :: (10116,Species) :: ['Rats']


abstract: Over the past decades, @entity1272 (serum @entity1025 <0.7 mmol/L) has been strongly associated with @entity6 ( @entity6 ). @entity1 with @entity1272 show a more rapid disease progression and have an increased risk for @entity2412 . Clinical studies demonstrate that @entity6 @entity1 with @entity1272 have reduced pancreatic b-cell activity and are more @entity2690 resistant. Moreover, dietary @entity1025 supplementation for @entity1 with @entity6 improves glucose metabolism and @entity2690 sensitivity. Intracellular @entity1025 regulates glucokinase, KATP channels, and L-type @entity141 channels in pancreatic b-cells, preceding @entity2690 secretion. Moreover, @entity8277 autophosphorylation is dependent on intracellular @entity1025 concentrations, making @entity1025 a direct factor in the development of @entity2690 resistance. Conversely, @entity2690 is an important regulator of @entity1025 homeostasis. In the kidney, @entity2690 activates the renal @entity1025 channel transient receptor potential melastatin type 6 that determines the final urinary @entity1025 excretion. Consequently, @entity1 with @entity6 and @entity1272 enter a vicious circle in which @entity1272 causes @entity2690 resistance and @entity2690 resistance reduces serum @entity1025 concentrations. This Perspective provides a systematic overview of the molecular mechanisms underlying the effects of @entity1025 on @entity2690 secretion and @entity2690 signaling. In addition to providing a review of current knowledge, we provide novel directions for future research and identify previously neglected contributors to @entity1272 in @entity6 .

title: XXXX in Type 2 Diabetes: A Vicious Circle?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['T2DM', 'type 2 diabetes mellitus']

entities_list: @entity1272 :: ('MESH:C537153', 'Disease') :: ['hypomagnesemia']

entities_list: @entity8277 :: ('3643', 'Gene') :: ['insulin receptor']

entities_list: @entity2412 :: ('MESH:D048909', 'Disease') :: ['diabetes complications']

answer: @entity1272 :: (MESH:C537153,Disease) :: ['Hypomagnesemia']


abstract: UNASSIGNED: Studies comparing rabbit antithymocyte globulin (rATG) and @entity1641 ATG (hATG) in @entity1 with @entity2150 ( @entity2150 ) have shown conflicting results. These studies included fewer than 60 subjects in the rATG arm with relatively short follow-up. A total of 169 @entity1 treated with rATG and 62 treated with hATG were included in this retrospective analysis, across 33 centers. @entity1 were treated with rATG or hATG plus cyclosporine A. Over half were classified, as having severe @entity2150 (SAA) or very severe @entity2150 (VSAA), and the mean follow-up was 45  months. There was no significant difference detected in cumulative response to treatment or survival between the rATG and hATG groups. The response to treatment was 63  % in the rATG group versus 66  % in the hATG group at 3  months. By 12  months, this pattern had reversed, and 84  % of rATG @entity1 had responded to treatment versus 76  % in the hATG group (n.s.). Early mortality due to @entity281 tended to be higher with rATG compared to hATG (n.s). rATG and hATG would seem to be therapeutically equivalent in SAA and VSAA. However, @entity1 treated with rATG may take longer to respond than those treated with hATG and may also require more active prevention of @entity281 .

title: Rabbit antithymocyte globulin versus horse antithymocyte globulin for treatment of acquired XXXX : a retrospective analysis.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'early infections']

entities_list: @entity2150 :: ('MESH:D000741', 'Disease') :: ['aplastic anemia', 'AA']

answer: @entity2150 :: (MESH:D000741,Disease) :: ['aplastic anemia']


abstract: @entity1 proprioception is essential for motor control, yet its central processing is still debated. Previous studies of passive movements and illusory vibration have reported inconsistent activation patterns related to proprioception, particularly in high-order sensorimotor cortices. We investigated brain activation specific to proprioception, its laterality, and changes following @entity64 . Twelve healthy and three @entity64 -affected individuals with @entity3325 participated. Proprioception was assessed clinically with the Wrist Position Sense Test, and @entity1 underwent functional magnetic resonance imaging scanning. An event-related study design was used, where each proprioceptive stimulus of passive wrist movement was followed by a motor response of mirror -copying with the other wrist. Left (LWP) and right (RWP) wrist proprioception were tested separately. Laterality indices (LIs) were calculated for the main cortical regions activated during proprioception. We found proprioception-related brain activation in high-order sensorimotor cortices in healthy @entity1 especially in the supramarginal gyrus (SMG LWP z   =   4.51, RWP z   =   4.24) and the dorsal premotor cortex (PMd LWP z   =   4.10, RWP z   =   3.93). Right hemispheric dominance was observed in the SMG (LI LWP mean 0.41, SD 0.22; RWP 0.29, SD 0.20), and to a lesser degree in the PMd (LI LWP 0.34, SD 0.17; RWP 0.13, SD 0.25). In @entity64 -affected @entity1 , the main difference in proprioception-related brain activation was reduced laterality in the right SMG. Our findings indicate that the SMG and PMd play a key role in proprioception probably due to their role in spatial processing and motor control, respectively. The findings from @entity64 --affected individuals suggest that decreased right SMG function may be associated with decreased proprioception. We recommend that clinicians pay particular attention to the assessment and rehabilitation of proprioception following right hemispheric lesions.

title: The Right Supramarginal Gyrus Is Important for Proprioception in Healthy and Stroke-Affected XXXX : A Functional MRI Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Human', 'participants']

entities_list: @entity3325 :: ('MESH:D020886', 'Disease') :: ['proprioceptive deficits']

answer: @entity1 :: (9606,Species) :: ['Participants']


abstract: INTRODUCTION: Lumbar degenerative spondylolisthesis is a major cause of impaired quality of life and diminished functional capacity in the elderly. @entity179 often involves only one or two level and tend to present with one or two level @entity612 . CASE REPORT: The authors describe an unusual case of degenerative spondylolisthesis involving 3 levels of the lumbar spine from L2 to L5. The @entity1 was a 58-year-old @entity1 who suffered @entity615 and @entity613 . Plain radiography revealed grade I degenerative spondylolisthesis at L2-L3, L3-L4 and L4-L5. Elevated pedicle-facet joint angles and W-type facet joints at the lumbar spine was observed. Magnetic resonance imaging showed L2-S1 @entity1745 at the lumbar spine. @entity1 underwent L2-S1 decompression laminectomy and posterior lateral fusion of L2-S1 with posterior instrumentation and bone grafting. Symptoms improved significantly at 4 months follow-up. CONCLUSION: Thorough evaluation for multilevel segmental involvement in degenerative spondylolisthesis is important because of the frequency of severe symptomatic @entity612 or foraminal encroachment. Good surgical outcome can be expected from decompression and stabilisation. The pathogenesis of multi-level lumbar degenerative spondylolisthesis can be complex and heterogeneous.

title: A case report of 3-level degenerative spondylolisthesis with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient', 'Patient']

entities_list: @entity612 :: ('MESH:D013130', 'Disease') :: ['spinal stenosis', 'spinal canal stenosis']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['chronic back pain']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['neurogenic claudication']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['Degenerative spondylolisthesis']

entities_list: @entity1745 :: ('MESH:D013117', 'Disease') :: ['spinal cord compression']

answer: @entity612 :: (MESH:D013130,Disease) :: ['spinal canal stenosis']


abstract: BACKGROUND _ PURPOSE: Globally, @entity6 is one of the most common non-contagious diseases resulting in severe complications. Fostered hope facilitates coping and improves self-care and one of the Factors affecting hope is religious beliefs. This research investigated the level of hope and its relationship with religious coping among @entity164 2 @entity6 @entity1 . MATERIAL _ METHODS: This correlation, cross-sectional study was conducted on 150 @entity1 with @entity164 2 @entity6 , who had been referred to the Karaj @entity6 Association during the period, March-June 2011, and selected through purposive sampling. A three-part questionnaire including demographic data, the Herth Hope Index, and a short form of religious coping, was used for data collection. The data were analyzed using descriptive and analytic statistics, including Pearson's correlation coefficient, the t-test, a one-way ANOVA, and a multiple regression analysis. The set significance level was p<0.05. RESULTS: The mean hope score was 34.89 (SD  8.75); most of the subjects (46.7%) showed high levels of hope. Positive religious coping, marital status, and social support significantly affected hope fostering(r=0.897, p =0.000). A significant negative relationship was found between hope and age (r=-0.373, p=0.000), and between hope and negative religious coping (r=-0.749, p=0.000). CONCLUSION: Positive religious coping, married life, and social support significantly affected the development of hope. Moreover, there was a significant positive relationship between positive religious coping and social support. So, strengthening social support could lead to increased levels of positive religious coping and fostering of hope.

title: The Relationship Between Hope and Religious Coping Among XXXX With Type 2 Diabetes.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: AIM: @entity741 is a life-threatening condition. Considerable doubts exist over the effects of this disease on @entity1 ' sexual activity and satisfaction. The aim of this study was to evaluate the relationship between @entity741 and sexual satisfaction. METHODS: In a retrospective cohort study, the convenience sample of 150 @entity1 exposure with @entity741 and 150 @entity1 without exposure it was drawn from Shahid Beheshti hospital, Kashan, Iran. Sampling was performed from March to September 2014. We employed the Larson's Sexual Satisfaction Questionnaire for gathering the data. Data were analyzed using descriptive statistics and Chi-square, t-test and linear regression analysis. RESULTS: The means of sexual satisfaction in @entity1 exposure with @entity741 and among the subjects without exposure it were 101.47  13.42 and 100.91  16.52, respectively. There was no significant difference between the two groups regarding sexual satisfaction. However, sexual satisfaction was significantly correlated with gender and the use of cardiac medications (P value<0.05). CONCLUSION: The level of sexual satisfaction in @entity1 with exposure @entity741 is similar to the @entity1 without exposure it. Moreover, the @entity1 and the @entity1 who do not receive cardiac medications have higher levels of sexual satisfaction. Nurses who are providing care to @entity1 with @entity741 need to pay closer attention to @entity1 education about sexual issues.

title: Relationship Between XXXX and Sexual Satisfaction.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people', 'men']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['Ischemic heart disease', 'ischemic heart disease']

answer: @entity741 :: (MESH:D017202,Disease) :: ['Ischemic Heart Disease']


abstract: OBJECT Ependymomas of the filum terminale provide specific surgical challenges due to their often enormous size, contact with nerve roots of the cauda equina and conus, and potential for @entity510 . This study presents treatment results for these @entity5 over a 30-year period. METHODS Among 1447 @entity1 with @entity5 of the spinal canal treated between 1980 and 2014, 618 @entity1 presented with extramedullary @entity5 . Of these, 42 @entity1 (25 males, 17 females) demonstrated a @entity424 in the lumbosacral region. Thirty-four @entity1 underwent 36 operations for 39 such @entity5 . The mean @entity1 age was 38    14 years (range 11-73 years), with an average clinical history of 37    67 months. @entity1 were followed through outpatient visits and questionnaires, with a mean follow-up of 10 years (127    100 months). Twenty-seven operations were performed to treat de novo @entity5 and the remainder were undertaken on recurrent @entity5 . Short-term results were determined for individual symptoms, and @entity5 recurrence rates were calculated with Kaplan-Meier statistical analyses. RESULTS Subarachnoid dissemination was observed in 11 @entity1 and was related to previous surgery in 9 @entity1 and associated with extensive @entity5 in 2 @entity1 . Gross-total resections (GTR) were achieved in 28 operations (77.7%) and subtotal resections in the remainder. Subtotal resections were restricted to @entity424 (61.5%). Radiotherapy was employed after 6 operations on unencapsulated @entity5 , with 5 of these also demonstrating subarachnoid seeding. Permanent surgical morbidity affected 3 @entity1 who experienced permanent @entity1494 , while 7 @entity1 showed no postoperative changes, and the remaining 26 operations were followed by improvements. Long-term outcome depended on the amount of resection and the presence of a @entity5 capsule. Eight of 9 @entity5 recurrences affected unencapsulated @entity5 , of which 3 had undergone GTR. The overall recurrence rates were 6.6%, 19.0%, and 37.0% after 1, 10, and 20 years, respectively. For @entity424 , the corresponding rates were 15.6%, 32.5%, and 66.2% after 1, 10, and 20 years, respectively, with significantly lower rates of 9.1% after 10 and 20 years for encapsulated @entity5 . Postoperative radiotherapy tended to prolong the recurrence-free interval for @entity1 with unencapsulated @entity5 . Five @entity1 @entity204 occurred during follow-up, of which 2 @entity204 were @entity5 related and occurred at 216 and 287 months after surgery. CONCLUSION @entity424 are @entity5 in the lumbosacral region, sometimes with an indolent course for long periods of time. Despite their delicate location and often enormous size, surgical morbidity in experienced hands is low, with good chances for postoperative clinical improvements and very low recurrence rates after GTR for encapsulated @entity5 . The role of postoperative radiotherapy remains controversial. Radiotherapy may be considered after incomplete resections of unencapsulated @entity5 and/or for @entity1 with @entity510 .

title: XXXX . Part 2: Ependymomas of the filum terminale.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity424 :: ('MESH:D004806', 'Disease') :: ['myxopapillary ependymoma', 'unencapsulated ependymomas', 'Extramedullary ependymomas']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['worsening of bladder function']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid dissemination']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'slow-growing tumors', 'tumors']

answer: @entity424 :: (MESH:D004806,Disease) :: ['Spinal ependymomas']


abstract: UNASSIGNED: Invasive coronary angiography (ICA) was the only method to image coronary arteries for a long time and is still the gold-standard. Technology of noninvasive imaging by coronary computed-tomography angiography (CCTA) has experienced remarkable progress during the last two decades. It is possible to visualize @entity731 in the vessel wall in contrast to "lumenography" performed by ICA. @entity453 can be ruled out by CCTA with excellent accuracy. The degree of stenoses is, however, often overestimated which impairs specificity. @entity731 can be characterized as calcified, non-calcified and partially calcified. Calcified plaques are usually quantified using the Agatston-Score. Higher scores are correlated with worse cardiovascular outcome and increased risk of @entity299 . For non-calcified or partially calcified plaques different angiographic findings like positive remodelling, a large necrotic core or spotty calcification more frequently lead to @entity583 . CCTA is an important tool with increasing clinical value for ruling out @entity453 or relevant stenoses as well as for advanced risk stratification.

title: Coronary CT Angiography in Managing XXXX .

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['Atherosclerotic lesions', 'atherosclerotic lesions']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarctions']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['Coronary artery disease', 'coronary artery disease']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

answer: @entity731 :: (MESH:D050197,Disease) :: ['Atherosclerosis']


abstract: BACKGROUND: @entity2341 ( @entity2341 ) is the most common of the ocular @entity129 .This study evaluates the types of @entity2341 and its management in @entity1 presenting to the paediatric and strabismus unit of a tertiary care eye hospital. METHODS: This case series study involved 41 @entity1 diagnosed with @entity2341 between January 2007 and December 2009. History of presenting complaints, past treatment and family history were recorded. Ocular examination and orthoptic assessment was carried out RESULTS: Forty one @entity1 were included in this case series study. It involved 10 right eyes, 27 @entity735 @entity1 . There were 26 females and 15 males. @entity2341 was present in 28 (68.3%), type 2 in 8 (19.5%), Type-3 in 4 (9.8%) and type-4 with synergistic divergence was present in 1 (2.4%) @entity1 . Comorbidity was present in 6(14.6%) @entity1 . Surgery was carried out in 26 (63.4%) @entity1 either for   abnormal head posturing or significant upshoots or down shoots. Upshoots noted in 21 eyes, were completely or partially resolved in 15 cases. Among 4 @entity1 with down shoots on adduction, complete resolution was seen in 1. The pre and post-operative measurements of horizontal deviation showed statistically significant difference in Duane type-1 and 2, where as in Duane type-3 it was not significant. One @entity1 with type-4 Duane did not undergo surgery. CONCLUSIONS: Recession of the horizontal recti is more effective in treating the upshoot or down shoot associated with @entity2341 as compared to recession and y-split of the horizontal muscle.

title: XXXX : surgical outcome and non ophthalmologic associations.

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['congenital cranial dysinnervation disorders']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2341 :: ('MESH:D004370', 'Disease') :: ['DRS', 'Duane retraction syndrome', 'Type-1 Duane syndrome', 'Duane syndrome']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['left eyes and both eyes of 4']

answer: @entity2341 :: (MESH:D004370,Disease) :: ['Duane's syndrome']


abstract: BACKGROUND: There are no conclusive cost-effectiveness studies measuring the efficacy of salvage LT after liver resection (LR) and radiofrequency ablation (RFA) in @entity1 with @entity157 ( @entity157 ) and compensated @entity82 . The aim of the present study is to compare liver transplantation (LT) versus locoregional therapy plus salvage LT (to treat @entity5 recurrence) in @entity1 with early @entity157 and compensated @entity82 . METHODS: Reference case: 55-year old male with @entity157 within Milan criteria and @entity1 -Pugh A @entity82 . The analysis was performed in two geographical cost settings: USA and Italy. Survival benefit measured in quality-adjusted life years (QALYs), costs (C) in US , incremental cost-effectiveness, willingness to pay, and net health benefit (NHB). RESULTS: In the base-case analysis, NHB of LT vs. LR and RFA was -1.7 and -1.3  years for @entity5   <=3  cm, -1.2 and -0.7 for single nodules measuring 3.1-5  cm and -0.7 and -0.7 for @entity5   <=3  cm in Italy. In USA, NHB of LT versus LR and RFA were -1.2 and -0.8  years for @entity5   <=3  cm, -0.9 and -0.5 for single nodules measuring 3.1-5  cm, and -0.5 and -0.4 for @entity5   <=  3  cm. On the Monte Carlo simulation, only young @entity1 with multi-nodular @entity157 and short waiting list time had a positive NHB. Salvage LT proved to be an ineffective cost strategy after RFA or LR. CONCLUSION: In @entity1 with @entity157 within Milan criteria and @entity1 -Pugh A @entity82 , LR and RFA were more cost-effective than LT. Salvage LT was not cost-effective.

title: The Relative Net Health Benefit of Liver Resection, Ablation, and Transplantation for Early XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'patients']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'early hepatocellular carcinoma']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'single tumor', 'multi-nodular tumor']

answer: @entity157 :: (MESH:D006528,Disease) :: ['Hepatocellular Carcinoma']


abstract: To determine the LH release response to @entity4082 in @entity1 with virilizing @entity774 ( @entity774 ), we examined six @entity1 with glucocorticoid-treated virilizing @entity774 , five @entity1 and one @entity1 , chonological age (CA) 4 years 2 months-15 years 9 months and bone age (BA) range 8-18 years. All the @entity1 but one, were treated with nocturnal @entity619 . Their ages at the onset of treatment ranged from 2 years 6 months to 13 years 8 months. An additional @entity1 (CA = 4 years 3 months and BA = 7-8 years) was studied 10 days after removal of a virilizing @entity652 . @entity4082 (3mg/kg/day) was administered orally in two doses/day for 8 days. Venous blood was collected on days 0, 4, 6 and 8. Two @entity1 were also studied in consecutive years. In three @entity1 no increase was noted over the basal levels of LH, but in the others LH rose during @entity4082 administration. In two @entity1 studied in consecutive years, there was detectable shift of LH release pattern. The basal LH levels and the sum of responses (day 4, 6 and 8) to @entity4082 and particularly their decimal logarithms were statistically significantly correlated with their respective BA. These results confirm that previous prolonged exposure to elevated concentrations of adrenal sex @entity230 , in @entity1 with treated virilizing @entity774 , may induce precocious maturation of the hypothalamic pubertal mechanism of LH secretion. This maturation was closely correlated with the degree of skeletal maturation.

title: Pubertal maturation of the lh stimulatory response to XXXX in congenital virilizing @entity774 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'girls', 'boy']

entities_list: @entity4082 :: ('MESH:D002996', 'Chemical') :: ['clomiphene citrate', 'clomiphene', 'Clomiphene citrate']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['dexamethasone']

entities_list: @entity230 :: ('MESH:D013256', 'Chemical') :: ['steroids']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['adrenal adenoma']

entities_list: @entity774 :: ('MESH:D000312', 'Disease') :: ['congenital adrenal hyperplasia', 'CAH']

answer: @entity4082 :: (MESH:D002996,Chemical) :: ['clomiphene citrate']


abstract: To determine the LH release response to @entity4082 in @entity1 with virilizing @entity774 ( @entity774 ), we examined six @entity1 with glucocorticoid-treated virilizing @entity774 , five @entity1 and one @entity1 , chonological age (CA) 4 years 2 months-15 years 9 months and bone age (BA) range 8-18 years. All the @entity1 but one, were treated with nocturnal @entity619 . Their ages at the onset of treatment ranged from 2 years 6 months to 13 years 8 months. An additional @entity1 (CA = 4 years 3 months and BA = 7-8 years) was studied 10 days after removal of a virilizing @entity652 . @entity4082 (3mg/kg/day) was administered orally in two doses/day for 8 days. Venous blood was collected on days 0, 4, 6 and 8. Two @entity1 were also studied in consecutive years. In three @entity1 no increase was noted over the basal levels of LH, but in the others LH rose during @entity4082 administration. In two @entity1 studied in consecutive years, there was detectable shift of LH release pattern. The basal LH levels and the sum of responses (day 4, 6 and 8) to @entity4082 and particularly their decimal logarithms were statistically significantly correlated with their respective BA. These results confirm that previous prolonged exposure to elevated concentrations of adrenal sex @entity230 , in @entity1 with treated virilizing @entity774 , may induce precocious maturation of the hypothalamic pubertal mechanism of LH secretion. This maturation was closely correlated with the degree of skeletal maturation.

title: Pubertal maturation of the lh stimulatory response to @entity4082 in congenital virilizing XXXX .

answer: @entity774 :: (MESH:D000312,Disease) :: ['adrenal hyperplasia']


abstract: BACKGROUND: Although of interest, few data exist on the clinical characteristics of Japanese @entity1 with an extremely high @entity412 level (>= 1000  mg/dL). OBJECTIVE: We assessed the clinical characteristics of Japanese @entity1 with an extremely high @entity412 level. METHODS: We investigated the presence of @entity453 , history of @entity788 , the presence of @entity1560 , and the potential causes of elevated @entity412 in Japanese subjects with an extremely high level of fasting @entity412 (>= 1000  mg/dL) among 70,368 subjects whose serum @entity412 was measured for any reason at Kanazawa University Hospital from April 2004 to March  2014. RESULTS: We identified 215 (0.31%) subjects (mean age, 46  years; male, 170, mean body mass index, 25  kg/m(2)) with severe @entity2298 . Among them, 4 (1.9%) subjects were classified as type I, 97 (45.1%) subjects were type IV, and 114 (53.0%) subjects were @entity30176 , according to Fredrickson's classification. Among 215 subjects, 116 subjects (54.0%) drank @entity285 , 58 (27.0%) showed heavy intake (>= 60  g/d), and 64 (29.8%) subjects had @entity6 . In total, 59 (27.4%) subjects had transient severe @entity2298 caused by @entity288 (N  =  19), antidepressant (N  =  18), @entity4445 and @entity230 for @entity981 (N  =  15), hormone replacement therapy for @entity0 (N  =  9), b-blocker (N  =  5), @entity1375 (N  =  4), pregnancy (N  =  4), and @entity7961 (N  =  2). As many as 119 (55.3%) subjects exhibited @entity1560 . Moreover, 12 (5.6%) and 17 (7.9%) subjects had a history of @entity788 and @entity453 , respectively. CONCLUSIONS: A variety of situations can cause severe @entity2298 . We suggest that potential secondary causes should be carefully assessed for such @entity1 .

title: Clinical characteristics of Japanese @entity1 with severe XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2298 :: ('MESH:D015228', 'Disease') :: ['hypertriglyceridemia']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatitis']

entities_list: @entity981 :: ('MESH:D054198', 'Disease') :: ['acute lymphoid leukemia']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty liver']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism']

entities_list: @entity7961 :: ('MESH:C580003', 'Disease') :: ['panhypopituitarism']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity30176 :: ('MESH:D006954', 'Disease') :: ['type V hyperlipidemia']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity2298 :: (MESH:D015228,Disease) :: ['hypertriglyceridemia']


abstract: BACKGROUND: Although of interest, few data exist on the clinical characteristics of Japanese @entity1 with an extremely high @entity412 level (>= 1000  mg/dL). OBJECTIVE: We assessed the clinical characteristics of Japanese @entity1 with an extremely high @entity412 level. METHODS: We investigated the presence of @entity453 , history of @entity788 , the presence of @entity1560 , and the potential causes of elevated @entity412 in Japanese subjects with an extremely high level of fasting @entity412 (>= 1000  mg/dL) among 70,368 subjects whose serum @entity412 was measured for any reason at Kanazawa University Hospital from April 2004 to March  2014. RESULTS: We identified 215 (0.31%) subjects (mean age, 46  years; male, 170, mean body mass index, 25  kg/m(2)) with severe @entity2298 . Among them, 4 (1.9%) subjects were classified as type I, 97 (45.1%) subjects were type IV, and 114 (53.0%) subjects were @entity30176 , according to Fredrickson's classification. Among 215 subjects, 116 subjects (54.0%) drank @entity285 , 58 (27.0%) showed heavy intake (>= 60  g/d), and 64 (29.8%) subjects had @entity6 . In total, 59 (27.4%) subjects had transient severe @entity2298 caused by @entity288 (N  =  19), antidepressant (N  =  18), @entity4445 and @entity230 for @entity981 (N  =  15), hormone replacement therapy for @entity0 (N  =  9), b-blocker (N  =  5), @entity1375 (N  =  4), pregnancy (N  =  4), and @entity7961 (N  =  2). As many as 119 (55.3%) subjects exhibited @entity1560 . Moreover, 12 (5.6%) and 17 (7.9%) subjects had a history of @entity788 and @entity453 , respectively. CONCLUSIONS: A variety of situations can cause severe @entity2298 . We suggest that potential secondary causes should be carefully assessed for such @entity1 .

title: Clinical characteristics of Japanese XXXX with severe @entity2298 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIM: Athletes typically maintain rigorous training and work programs to be able to participate in competitions. An injury that occurs during the competition that causes withdrawal from the competition and a possible departure from sports, can render results athletes' and their support staff's efforts as meaningless. The early detection of @entity130 in the competition and developing preventive training programs can help ensure that participating in competitions and the associated preparatory efforts are not wasted. In this study, the @entity2587 discussed occurred during training and competition events of the Turkish Shooting Sportive group. Body parts of @entity130 are determined and exercise programs focused on the affected body parts are developed. METHODS: 729 athletes (285 female, 444 male) who participated in Turkish Shooting Sports Championship during the 2010--2011 competition period participated in the study. Athletes were given a questionnaire that was developed prior to the event, and the questionnaire was filled in during interviews conducted one--on--one. Data collected from the questionnaire and the software program "SPSS 16.0" is used to analyze the results. The study was completed in six months. RESULTS: The results showed that the most of the @entity130 that occurred during training were strain and @entity121 whereas most of the @entity130 occurred during the actual competition were strain, @entity121 , @entity924 , and @entity6475 . The results also indicated that during training, the most frequently--occurring @entity130 were in shoulder, @entity291 --thigh, hand and wrist; whereas during the competition, it was manifested in the shoulder, foot and ankle. CONCLUSION: Muscle strengthening, stretching and proprioception exercises for these body parts should be included as part of the athletic training program.

title: Analysis of XXXX related with shooting.

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['tendinitis']

entities_list: @entity2587 :: ('MESH:D001265', 'Disease') :: ['sports injuries']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle tears']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['injuries']

answer: @entity2587 :: (MESH:D001265,Disease) :: ['sports injuries']


abstract: BACKGROUND: Spinning is a popular indoor stationary cycling program that uses group classes as a motivational tool. Exertional @entity5925 (ER) is frequently reported in athletes and military recruits; however, infrequently it has been reported after spinning class. ER is diagnosed by clinical history, physical exam, and laboratory values. Hydration, electrolyte management, and @entity158 control are key components to treatment of this condition. Severe cases can be complicated by @entity810 , @entity2054 , @entity943 , and disseminated @entity5642 . PURPOSE: WE describe three cases of admission due to @entity5925 after spinning. The diagnosis, admission criteria, and medical treatment of ER are presented in the context of a literature review. STUDY DESIGN: A retrospective review of three cases with review of the current literature. METHODS: The medical and laboratory records of three @entity1 cases were reviewed. A search of the PubMed database was used to perform a comprehensive review of exertional @entity5925 . Our institution's IRB reviewed this study. RESULTS: We report three cases of exertional @entity5925 after spinning and describe the diagnostic workup and medical management of these @entity1 . CONCLUSIONS: The diagnosis of ER is made by clinical history, physical exam, and laboratory values. The disease spectrum ranges from mild to severe with the potential of serious complications in some @entity1 . We demonstrate three cases of ER in deconditioned individuals who presented to the emergency department for evaluation. Careful medical management and @entity1 monitoring resulted in improved @entity1 symptomatology and eventual return to physical activity.

title: Exertional XXXX after spinning: case series and review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5925 :: ('MESH:D012206', 'Disease') :: ['rhabdomyolysis']

entities_list: @entity2054 :: ('MESH:D003161', 'Disease') :: ['compartment syndrome']

entities_list: @entity5642 :: ('MESH:D004211', 'Disease') :: ['intravascular coagulation']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmia']

answer: @entity5925 :: (MESH:D012206,Disease) :: ['rhabdomyolysis']


abstract: PURPOSE: During lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to @entity420 could enhance @entity41 during resection. PROCEDURES: @entity19 with @entity5 received a contrast agent targeting @entity1501 receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three @entity1 with @entity2220 . RESULTS: The peak @entity5 -to-background ratio (TBR) of @entity19 @entity5 was 3.9. Fluorescence peaked at 2  h and was not improved beyond 0.1  mg/kg. Traditional inspection identified 30  % of @entity19 with positive margins. Molecular imaging identified an additional 50  % of @entity41 deposits (p   <   0.05). The fluorescent probe visually enhanced all @entity1 @entity5 with a mean TBR of 3.5. CONCLUSIONS: Molecular imaging is an important adjunct to traditional inspection to identify surgical margins after @entity5 resection.

title: Intraoperative Molecular Imaging of Lung XXXX Can Identify @entity41 Cells at the Surgical Margins.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity41 :: ('MESH:D018365', 'Disease') :: ['residual tumor']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'flank tumors', 'tumors']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['pulmonary adenocarcinomas']

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']

answer: @entity420 :: (MESH:D000230,Disease) :: ['Adenocarcinoma']


abstract: PURPOSE: During lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to @entity420 could enhance @entity41 during resection. PROCEDURES: @entity19 with @entity5 received a contrast agent targeting @entity1501 receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three @entity1 with @entity2220 . RESULTS: The peak @entity5 -to-background ratio (TBR) of @entity19 @entity5 was 3.9. Fluorescence peaked at 2  h and was not improved beyond 0.1  mg/kg. Traditional inspection identified 30  % of @entity19 with positive margins. Molecular imaging identified an additional 50  % of @entity41 deposits (p   <   0.05). The fluorescent probe visually enhanced all @entity1 @entity5 with a mean TBR of 3.5. CONCLUSIONS: Molecular imaging is an important adjunct to traditional inspection to identify surgical margins after @entity5 resection.

title: Intraoperative Molecular Imaging of Lung @entity420 Can Identify XXXX Cells at the Surgical Margins.

answer: @entity41 :: (MESH:D018365,Disease) :: ['Residual Tumor']


abstract: INTRODUCTION: Interobserver variability in the definition of target volumes (TVs) is a well-known confounding factor in (multicentre) clinical studies employing radiotherapy. Therefore, detailed contouring guidelines are provided in the prospective randomised multicentre PET-Plan (NCT00697333) clinical trial protocol. This trial compares strictly FDG-PET-based TV delineation with conventional TV delineation in @entity1 with locally advanced @entity1149 ( @entity1149 ). Despite detailed contouring guidelines, their interpretation by different radiation oncologists can vary considerably, leading to undesirable discrepancies in TV delineation. Considering this, as part of the PET-Plan study quality assurance (QA), a contouring dummy run ( @entity5958 ) consisting of two phases was performed to analyse the interobserver variability before and after teaching. MATERIALS AND METHODS: In the first phase of the @entity5958 ( @entity5958 ), radiation oncologists from 14 study centres were asked to delineate TVs as defined by the study protocol (gross TV, GTV; and two clinical TVs, CTV-A and CTV-B) in a test @entity1 . A teaching session was held at a study group meeting, including a discussion of the results focussing on discordances in comparison to the per-protocol solution. Subsequently, the second phase of the @entity5958 ( @entity5958 ) was performed in order to evaluate the impact of teaching. RESULTS: Teaching after @entity5958 resulted in a reduction of absolute TVs in @entity5958 , as well as in better concordance of TVs. The Overall Kappa(k) indices increased from 0.63 to 0.71 (GTV), 0.60 to 0.65 (CTV-A) and from 0.59 to 0.63 (CTV-B), demonstrating improvements in overall interobserver agreement. CONCLUSION: Contouring DRs and study group meetings as part of QA in multicentre clinical trials help to identify misinterpretations of per-protocol TV delineation. Teaching the correct interpretation of protocol contouring guidelines leads to a reduction in interobserver variability and to more consistent contouring, which should consequently improve the validity of the overall study results.

title: A teaching intervention in a contouring dummy run improved target volume delineation in locally advanced XXXX : Reducing the interobserver variability in multicentre clinical studies.

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancer']


abstract: BACKGROUND: The mammary glands of @entity1707 share many functional and morphological similarities with the breasts of @entity1 , raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis. Here we sought to establish a model for the efficient manipulation and transformation of porcine mammary epithelial cells (pMEC) in vitro and @entity5 growth in vivo. METHODS: We utilized a vector encoding the red florescent protein tdTomato to transduce populations of pMEC from Yorkshire -Hampshire crossbred female @entity1707 in vitro and in vivo. Populations of primary pMEC were then separated by FACS using markers to distinguish epithelial cells ( @entity675 -) from stromal cells ( @entity675 +), with or without further enrichment for basal and luminal progenitor cells ( @entity9617 +). These separated pMEC populations were transduced by lentivirus encoding murine polyomavirus T antigens (Tag) and tdTomato and engrafted to orthotopic or ectopic sites in immunodeficient NOD.Cg-Prkdc (scid) @entity42327 (tm1Wjl) /SzJ (NSG) @entity19 . RESULTS: We demonstrated that lentivirus effectively transduces pMEC in vitro and in vivo. We further established that lentivirus can be used for oncogenic-transformation of pMEC ex vivo for generating @entity5 in vivo. Oncogenic transformation was confirmed in vitro by anchorage-independent growth, increased cell proliferation, and expression of @entity986 , @entity7596 and @entity876 alongside decreased phosphorylation of Rb. Moreover, Tag-transformed @entity675 - and @entity675 - @entity9617   +   pMECs developed site-specific @entity5 of differing histopathologies in vivo. CONCLUSIONS: Herein we establish a model for the transduction and oncogenic transformation of pMEC. This is the first report describing a porcine model of mammary epithelial cell tumorigenesis that can be applied to the study of @entity1 @entity0 .

title: Neoplastic transformation of porcine mammary epithelial cells in vitro and XXXX formation in vivo.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'mammary tumors', 'tumors']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: UNASSIGNED: Diagnosis of @entity7393 associated myeloencephalopathy (EHM) can be troublesome, but early recognition and knowledge of risk factors are essential for prevention and control. The objectives for this study are to (1) describe EHM in France, (2) improve clinical recognition, (3) identify risk factors. Through epidemiosurveillance of acute neurological cases (all considered to be potentially infectious cases) in France (2008-2011), 26 EHM cases were identified and 29 EHM negative control cases. EHM cases were described and compared to controls with univariate, multivariate and classification and regression tree analysis. EHM cases had a 46% fatality rate and were frequently isolated cases. Most showed ataxia, paresis and a @entity1971 , yet presence of other neurological signs was variable. Statistical analysis identified the following variables to be significantly associated to EHM compared to controls: introduction of a new @entity1641 to the herd, @entity1971 , larger herd size, saddle @entity1641 and month of occurrence. The presence of many isolated cases, and less typical and variable clinical presentations emphasize the difficulty in diagnosing EHM. Nevertheless, history and clinical examination of acute neurological cases can be valuable in recognizing EHM early as well in order to select those cases that need further laboratory testing and infection control measures. Moreover, with a different study format and geographic location, risk factors were found to be similar to previous studies, therefore strengthening their significance to the spread of EHM.

title: A retrospective study on XXXX associated myeloencephalopathy in France (2008-2011).

entities_list: @entity1971 :: ('MESH:D011128', 'Disease') :: ['cauda equina syndrome']

entities_list: @entity7393 :: ('10326', 'Species') :: ['equine herpesvirus-1']

answer: @entity7393 :: (10326,Species) :: ['equine herpesvirus type-1']


abstract: INTRODUCTION: The knee is the most frequent location for @entity421 (60%). Until 30 years ago @entity1 with @entity421 were treated with an amputation of the affected limb; today 85% of these cases are treated with a "Limb Salvage" procedure, through replacement of the affected bone with a mega prosthesis implant. AIM: To measure functional recovery of @entity1 with a knee mega-prothesis and how rehabilitation impacts on quality of life (QOL); another aim is to define rehabilitation guidelines to manage these @entity1 in the rehabilitation pathway. METHODS: A sample of outpatients with knee mega-prosthesis were selected in the follow-up orthopedic oncology surgery between march and may 2013. We measured the functional outcome using the multidimensional standardized Musculoskeletal Tumor Society scale (MSTS) that gives a score (0-5) for each of 7 items: @entity158 , range of motion, stability, deformity, strength, functional activity, emotional acceptance. RESULTS: The sample included 28 outpatients. The median MSTS score was 29 (min 19, max 33) equal to 83%. Only 14 @entity1 (50%) followed a correct rehabilitation path after surgery. DISCUSSION: 21 cases got "excellent" outcomes and 3 "good" (based on MSTS classification). In few cases (n 4) the outcome was "fairly good", related to necessity of a prosthesis surgical revision based on instability of implant (because of usage). Quadricep strength is the item that most affects the final score. There is a statistically significant correlation between high scores and @entity1 who have recently undergone surgery. We found higher scores in @entity1 that followed a physiotherapy program after surgery: the difference was statistically significant. CONCLUSIONS: Mega-prosthesis implants give satisfactory functional outcomes. These outcomes keep high score in time. It is recommended to follow the guidelines described in the purposed rehabilitation program.

title: [Rehabilitation pathway after knee arthroplasty with mega prosthesis in XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity421 :: ('MESH:D012516', 'Disease') :: ['osteosarcoma']

answer: @entity421 :: (MESH:D012516,Disease) :: ['osteosarcoma']


abstract: UNASSIGNED: There is a growing consensus that long-term deficits in the brain are due to dynamic interactions between multiple neural and immune cell types. Specifically, radiation induces an inflammatory response, including changes in neuromodulatory pro- and anti-inflammatory cytokine secretion. The purpose of this study was to establish that there is sympathetic involvement in radiation-induced decrements early in in vivo immune function host defense. Female, 8-9 week-old C57BL/6J @entity19 were exposed to whole-body irradiation (WBI). There were 8 groups with radiation (0 vs. 3Gy protons), immune challenge ( @entity526 ) and exposure to the sympathetic ganglionic blocker, @entity14523 (1mg/kg weight, i.p.), as independent variables. Ten days post-irradiation, @entity19 were inoculated with @entity526 intraperitoneally and sacrificed 90-120min later. The data suggest that radiation-induced changes in immune function may in part be mediated by the sympathetic nervous system. Briefly, we found that radiation augments the bacteria-induced inflammatory cytokine response, particularly those cytokines involved in innate immunity. However, this augmentation can be reduced by the ganglionic blockade.

title: XXXX , a sympathetic ganglionic blocker, moderates the effects of whole-body irradiation (WBI) on early host defense to a live bacterial challenge.

entities_list: @entity14523 :: ('MESH:D002714', 'Chemical') :: ['chlorisondamine']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity14523 :: (MESH:D002714,Chemical) :: ['Chlorisondamine']


abstract: CONTEXT: There is limited literature on characteristics of telephone triage programs and the nature of interventions in palliative care. OBJECTIVES: Our aim was to determine frequency and type of care provided by a Supportive Care Center Telephone Triaging Program (SCCTP) in advanced @entity5 @entity1 (ACPs). METHODS: Electronic medical records were reviewed of 400 consecutive ACPs referred to palliative care at a comprehensive @entity5 center and given access to the SCCTP: 200 from the outpatient (OP) supportive care center and 200 from inpatient (IP) palliative care given access after discharge. We reviewed call frequency, type, reason, and outcomes including @entity158 and other symptoms (Edmonton Symptom Assessment Scale and Memorial Delirium Assessment Scale [MDAS]) associated with utilization of the SCCTP. RESULTS: A total of 375 @entity1 were evaluable. One hundred fifteen of 400 @entity1 (29%) used the SCCTP: 96 OPs (83%) used the SCCTP vs. only 19 IPs (17%) (P  <  0.001). The most common reasons for calls were @entity158 (24%), @entity158 medication refills (24%), and counseling (12%). For 115 phone calls, 43% (145 of 340) of recommendations were regarding care at home and 56% were regarding opioids. @entity1 who used the SCCTP had worse @entity158 (P  =  0.006), @entity1295 (P  =  0.045), @entity308 (P  =  0.041), and well-being (P  =  0.015) and better MDAS scores (P  =  0.014) compared with nonusers. OPs had a higher prevalence of symptom distress (P  =  0.013), @entity308 (P  <  0.001), @entity148 (P  <  0.01), and @entity22 scores (P  =  0.001); MDAS scores were significantly higher in IPs (P  <  0.001). CONCLUSION: In this study, we found that overall utilization of the SCCTP by ACPs referred to palliative care was relatively low at 28.7%. The use of the SCCTP was particularly poor among the IPs on discharge. @entity1 who used SCCTP had worse @entity158 , @entity1295 , @entity308 , and well-being scores and better delirium scores.

title: The Frequency and Factors Associated With the Use of a Dedicated Supportive Care Center Telephone Triaging Program in @entity1 With @entity5 at a XXXX Center.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['insomnia']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Comprehensive Cancer']


abstract: CONTEXT: There is limited literature on characteristics of telephone triage programs and the nature of interventions in palliative care. OBJECTIVES: Our aim was to determine frequency and type of care provided by a Supportive Care Center Telephone Triaging Program (SCCTP) in advanced @entity5 @entity1 (ACPs). METHODS: Electronic medical records were reviewed of 400 consecutive ACPs referred to palliative care at a comprehensive @entity5 center and given access to the SCCTP: 200 from the outpatient (OP) supportive care center and 200 from inpatient (IP) palliative care given access after discharge. We reviewed call frequency, type, reason, and outcomes including @entity158 and other symptoms (Edmonton Symptom Assessment Scale and Memorial Delirium Assessment Scale [MDAS]) associated with utilization of the SCCTP. RESULTS: A total of 375 @entity1 were evaluable. One hundred fifteen of 400 @entity1 (29%) used the SCCTP: 96 OPs (83%) used the SCCTP vs. only 19 IPs (17%) (P  <  0.001). The most common reasons for calls were @entity158 (24%), @entity158 medication refills (24%), and counseling (12%). For 115 phone calls, 43% (145 of 340) of recommendations were regarding care at home and 56% were regarding opioids. @entity1 who used the SCCTP had worse @entity158 (P  =  0.006), @entity1295 (P  =  0.045), @entity308 (P  =  0.041), and well-being (P  =  0.015) and better MDAS scores (P  =  0.014) compared with nonusers. OPs had a higher prevalence of symptom distress (P  =  0.013), @entity308 (P  <  0.001), @entity148 (P  <  0.01), and @entity22 scores (P  =  0.001); MDAS scores were significantly higher in IPs (P  <  0.001). CONCLUSION: In this study, we found that overall utilization of the SCCTP by ACPs referred to palliative care was relatively low at 28.7%. The use of the SCCTP was particularly poor among the IPs on discharge. @entity1 who used SCCTP had worse @entity158 , @entity1295 , @entity308 , and well-being scores and better delirium scores.

title: The Frequency and Factors Associated With the Use of a Dedicated Supportive Care Center Telephone Triaging Program in @entity1 With XXXX at a @entity5 Center.

answer: @entity5 :: (MESH:D009369,Disease) :: ['Advanced Cancer']


abstract: CONTEXT: There is limited literature on characteristics of telephone triage programs and the nature of interventions in palliative care. OBJECTIVES: Our aim was to determine frequency and type of care provided by a Supportive Care Center Telephone Triaging Program (SCCTP) in advanced @entity5 @entity1 (ACPs). METHODS: Electronic medical records were reviewed of 400 consecutive ACPs referred to palliative care at a comprehensive @entity5 center and given access to the SCCTP: 200 from the outpatient (OP) supportive care center and 200 from inpatient (IP) palliative care given access after discharge. We reviewed call frequency, type, reason, and outcomes including @entity158 and other symptoms (Edmonton Symptom Assessment Scale and Memorial Delirium Assessment Scale [MDAS]) associated with utilization of the SCCTP. RESULTS: A total of 375 @entity1 were evaluable. One hundred fifteen of 400 @entity1 (29%) used the SCCTP: 96 OPs (83%) used the SCCTP vs. only 19 IPs (17%) (P  <  0.001). The most common reasons for calls were @entity158 (24%), @entity158 medication refills (24%), and counseling (12%). For 115 phone calls, 43% (145 of 340) of recommendations were regarding care at home and 56% were regarding opioids. @entity1 who used the SCCTP had worse @entity158 (P  =  0.006), @entity1295 (P  =  0.045), @entity308 (P  =  0.041), and well-being (P  =  0.015) and better MDAS scores (P  =  0.014) compared with nonusers. OPs had a higher prevalence of symptom distress (P  =  0.013), @entity308 (P  <  0.001), @entity148 (P  <  0.01), and @entity22 scores (P  =  0.001); MDAS scores were significantly higher in IPs (P  <  0.001). CONCLUSION: In this study, we found that overall utilization of the SCCTP by ACPs referred to palliative care was relatively low at 28.7%. The use of the SCCTP was particularly poor among the IPs on discharge. @entity1 who used SCCTP had worse @entity158 , @entity1295 , @entity308 , and well-being scores and better delirium scores.

title: The Frequency and Factors Associated With the Use of a Dedicated Supportive Care Center Telephone Triaging Program in XXXX With @entity5 at a @entity5 Center.

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: Reported @entity9963 prevalence varies widely, with an estimated prevalence of 0.2% in the general population. Sensitization to fish can occur by ingestion, skin contact or inhalation. The manifestations can be IgE or non-IgE mediated. Several fish allergens have been identified, with parvalbumins being the major allergen in various species. Allergenicity varies among fish species and is affected by processing or preparation methods. Adverse reactions after eating fish are often claimed to be ' @entity566 ' but could be a reaction to hidden food allergen, fish parasite, fish toxins or @entity112 in spoiled fish. Identifying such causes would allow free consumption of fish. Correct diagnosis of @entity9963 , including the specific species, might provide the @entity1 with safe alternatives. @entity1 have been generally advised for strict universal avoidance of fish. However, testing with various fish species or preparations might identify one or more forms that can be tolerated.

title: Fish-allergic XXXX may be able to eat fish.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patient']

entities_list: @entity9963 :: ('MESH:D005393', 'Disease') :: ['fish allergy']

entities_list: @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Molecular genetics now plays a crucial role in diagnosis, the identification of prognostic markers, and monitoring of @entity1583 . Demonstration of acquired changes such as the @entity4016 @entity4017 mutation within @entity5 ( @entity5 ) has quickly moved from a research setting to the diagnostic laboratory. Microfluidics-based assays can reduce the assay time and sample/reagent consumption and enhance the reaction efficiency; however, no current assay has integrated isothermal amplification for point-of-care @entity5 @entity4016 @entity4017 mutation testing with a microchip. In this report, an integrated microchip that performs the whole @entity1 blood genomic DNA extraction, loop-mediated isothermal nucleic acid amplification (LAMP) and visual detection for point-of-care genetic mutation testing is demonstrated. This method was validated on DNA from cell lines as well as on whole blood from @entity1 with @entity5 . The results were compared with those obtained by unlabeled probe melting curve analysis. This chip enjoys a high accuracy, operability, and cost/time efficiency within 1h. All these benefits provide the chip with a potency toward a point-of-care genetic analysis. All samples identified as positive by unlabeled probe melting curve analysis (n=27) proved positive when tested by microchip assay. None of the 30 negative controls gave false positive results. In addition, a @entity1 with @entity6582 vera diagnosed as being @entity4016 @entity4017 -negative by unlabeled probe melting curve analysis was found to be positive by the microchip. This microchip would possibly be very attractive in developing a point-of-care platform for quick preliminary diagnosis of @entity5 or other severe illness in resource-limited settings.

title: Toward point-of-care testing for XXXX @entity4017 mutation on a microchip.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients', 'patient']

entities_list: @entity6582 :: ('MESH:D011086', 'Disease') :: ['polycythemia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['myeloproliferative neoplasms', 'MPN']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematological malignancies']

answer: @entity4016 :: (3717,Gene) :: ['JAK2']


abstract: UNASSIGNED: Molecular genetics now plays a crucial role in diagnosis, the identification of prognostic markers, and monitoring of @entity1583 . Demonstration of acquired changes such as the @entity4016 @entity4017 mutation within @entity5 ( @entity5 ) has quickly moved from a research setting to the diagnostic laboratory. Microfluidics-based assays can reduce the assay time and sample/reagent consumption and enhance the reaction efficiency; however, no current assay has integrated isothermal amplification for point-of-care @entity5 @entity4016 @entity4017 mutation testing with a microchip. In this report, an integrated microchip that performs the whole @entity1 blood genomic DNA extraction, loop-mediated isothermal nucleic acid amplification (LAMP) and visual detection for point-of-care genetic mutation testing is demonstrated. This method was validated on DNA from cell lines as well as on whole blood from @entity1 with @entity5 . The results were compared with those obtained by unlabeled probe melting curve analysis. This chip enjoys a high accuracy, operability, and cost/time efficiency within 1h. All these benefits provide the chip with a potency toward a point-of-care genetic analysis. All samples identified as positive by unlabeled probe melting curve analysis (n=27) proved positive when tested by microchip assay. None of the 30 negative controls gave false positive results. In addition, a @entity1 with @entity6582 vera diagnosed as being @entity4016 @entity4017 -negative by unlabeled probe melting curve analysis was found to be positive by the microchip. This microchip would possibly be very attractive in developing a point-of-care platform for quick preliminary diagnosis of @entity5 or other severe illness in resource-limited settings.

title: Toward point-of-care testing for @entity4016 XXXX mutation on a microchip.

answer: @entity4017 :: (p|SUB|V|617|F,ProteinMutation) :: ['V617F']


abstract: UNASSIGNED: Episodic @entity5764 represents an important and underappreciated clinical feature in pediatric @entity148 . This study examined the incidence and clinical correlates of @entity5764 in @entity1 with @entity148 . Change in @entity5764 during treatment for @entity148 was also examined. @entity1 consisted of 107 @entity1 diagnosed with an @entity148 and their parents. @entity1 completed structured clinical interviews and questionnaire measures to assess @entity5764 , @entity73 , family accommodation and caregiver strain, as well as the quality of the @entity1 's relationship with family and peers. @entity5764 was a common feature amongst @entity1 with @entity148 . @entity5764 was associated with a more severe clinical profile, including increased @entity148 severity, functional impairment, family accommodation and caregiver strain, as well as poorer relationships with parents, siblings, extended family and peers. @entity5764 was more common in @entity1 with separation @entity148 , comorbid @entity148 , @entity71 and @entity146 , but not depressive symptoms. @entity5764 predicted higher levels of functional impairment, beyond the effect of @entity148 severity. @entity5764 severity reduced over treatment in line with changes in @entity148 . Findings suggest that @entity5764 is a marker of greater psychopathology in anxious youth. Standard cognitive behavioral treatment for @entity148 appears to reduce @entity5764 without adjunctive treatment.

title: Incidence, clinical correlates and treatment effect of XXXX in anxious @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Participants', 'child']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['behavioral disorders']

entities_list: @entity71 :: ('MESH:D001289', 'Disease') :: ['attention deficit/hyperactivity disorder']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['anxiety, functional impairment']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety symptoms', 'anxiety disorder', 'anxiety', 'anxiety disorders']

answer: @entity5764 :: (101669765,Gene) :: ['rage']


abstract: UNASSIGNED: Episodic @entity5764 represents an important and underappreciated clinical feature in pediatric @entity148 . This study examined the incidence and clinical correlates of @entity5764 in @entity1 with @entity148 . Change in @entity5764 during treatment for @entity148 was also examined. @entity1 consisted of 107 @entity1 diagnosed with an @entity148 and their parents. @entity1 completed structured clinical interviews and questionnaire measures to assess @entity5764 , @entity73 , family accommodation and caregiver strain, as well as the quality of the @entity1 's relationship with family and peers. @entity5764 was a common feature amongst @entity1 with @entity148 . @entity5764 was associated with a more severe clinical profile, including increased @entity148 severity, functional impairment, family accommodation and caregiver strain, as well as poorer relationships with parents, siblings, extended family and peers. @entity5764 was more common in @entity1 with separation @entity148 , comorbid @entity148 , @entity71 and @entity146 , but not depressive symptoms. @entity5764 predicted higher levels of functional impairment, beyond the effect of @entity148 severity. @entity5764 severity reduced over treatment in line with changes in @entity148 . Findings suggest that @entity5764 is a marker of greater psychopathology in anxious youth. Standard cognitive behavioral treatment for @entity148 appears to reduce @entity5764 without adjunctive treatment.

title: Incidence, clinical correlates and treatment effect of @entity5764 in anxious XXXX .

answer: @entity1 :: (9606,Species) :: ['children']


abstract: BACKGROUND AND PURPOSE: The aim of the study was to determine the effectiveness of @entity661 for treatment of compressive @entity174 . MATERIALS AND METHODS: A retrospective analysis was conducted on 24 @entity1 with 58 symptomatic @entity174 treated by balloon kyphoplasty. Visual Analogue @entity158 Scale (VAS) and @entity717 Index (ODI) were used to assess @entity174 -related @entity158 and @entity1 's disability: preoperatively and within 12-months follow-up. Following the procedures to evaluate the change of @entity85 , the angle of local @entity1513 was measured. RESULTS: Preoperative VAS score was 6.54, at discharge it significantly regressed in 95.8% of @entity1 . The overall VAS score at discharge was 1.25 and within 12 months decreased to 0.26. Preoperative ODI score was 50%, at follows-up in all @entity1 it decreased, ranging from 21% to 10%. Reduction of local @entity1513 was achieved in 30 (51.7%) vertebrae by average 4.3  . In 9 (37.5%) @entity1 @entity1513 of all augmented vertebrae was reduced, in 7 (29.2%) @entity1 procedures reduced @entity1513 in part of augmented vertebrae and in 8 @entity1 (33.3%) @entity1513 remained unchanged. Asymptomatic complications included cement leak in 10 (17%) vertebrae and intraoperative rupture of 4 (4%) balloons. CONCLUSIONS: Rapid significant @entity158 relief after kyphoplasty followed by long-term @entity158 release and disability reduction obtained in all @entity1 was most probably the result of @entity3574 . The correction of local @entity1513 had no influence on the outcome.

title: @entity661 in the treatment of painful vertebral compression fractures: Effect on local XXXX and one-year outcomes in @entity158 and disability.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture', 'vertebral fractures']

entities_list: @entity3574 :: ('OMIM:277300', 'Disease') :: ['vertebral augmentation']

entities_list: @entity661 :: ('MESH:D054549', 'Disease') :: ['percutaneous balloon kyphoplasty']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['Oswestry Disability']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['vertebral deformity']

answer: @entity1513 :: (MESH:D007738,Disease) :: ['kyphosis']


abstract: BACKGROUND AND PURPOSE: The aim of the study was to determine the effectiveness of @entity661 for treatment of compressive @entity174 . MATERIALS AND METHODS: A retrospective analysis was conducted on 24 @entity1 with 58 symptomatic @entity174 treated by balloon kyphoplasty. Visual Analogue @entity158 Scale (VAS) and @entity717 Index (ODI) were used to assess @entity174 -related @entity158 and @entity1 's disability: preoperatively and within 12-months follow-up. Following the procedures to evaluate the change of @entity85 , the angle of local @entity1513 was measured. RESULTS: Preoperative VAS score was 6.54, at discharge it significantly regressed in 95.8% of @entity1 . The overall VAS score at discharge was 1.25 and within 12 months decreased to 0.26. Preoperative ODI score was 50%, at follows-up in all @entity1 it decreased, ranging from 21% to 10%. Reduction of local @entity1513 was achieved in 30 (51.7%) vertebrae by average 4.3  . In 9 (37.5%) @entity1 @entity1513 of all augmented vertebrae was reduced, in 7 (29.2%) @entity1 procedures reduced @entity1513 in part of augmented vertebrae and in 8 @entity1 (33.3%) @entity1513 remained unchanged. Asymptomatic complications included cement leak in 10 (17%) vertebrae and intraoperative rupture of 4 (4%) balloons. CONCLUSIONS: Rapid significant @entity158 relief after kyphoplasty followed by long-term @entity158 release and disability reduction obtained in all @entity1 was most probably the result of @entity3574 . The correction of local @entity1513 had no influence on the outcome.

title: XXXX in the treatment of painful vertebral compression fractures: Effect on local @entity1513 and one-year outcomes in @entity158 and disability.

answer: @entity661 :: (MESH:D054549,Disease) :: ['Percutaneous balloon kyphoplasty']


abstract: BACKGROUND AND PURPOSE: The aim of the study was to determine the effectiveness of @entity661 for treatment of compressive @entity174 . MATERIALS AND METHODS: A retrospective analysis was conducted on 24 @entity1 with 58 symptomatic @entity174 treated by balloon kyphoplasty. Visual Analogue @entity158 Scale (VAS) and @entity717 Index (ODI) were used to assess @entity174 -related @entity158 and @entity1 's disability: preoperatively and within 12-months follow-up. Following the procedures to evaluate the change of @entity85 , the angle of local @entity1513 was measured. RESULTS: Preoperative VAS score was 6.54, at discharge it significantly regressed in 95.8% of @entity1 . The overall VAS score at discharge was 1.25 and within 12 months decreased to 0.26. Preoperative ODI score was 50%, at follows-up in all @entity1 it decreased, ranging from 21% to 10%. Reduction of local @entity1513 was achieved in 30 (51.7%) vertebrae by average 4.3  . In 9 (37.5%) @entity1 @entity1513 of all augmented vertebrae was reduced, in 7 (29.2%) @entity1 procedures reduced @entity1513 in part of augmented vertebrae and in 8 @entity1 (33.3%) @entity1513 remained unchanged. Asymptomatic complications included cement leak in 10 (17%) vertebrae and intraoperative rupture of 4 (4%) balloons. CONCLUSIONS: Rapid significant @entity158 relief after kyphoplasty followed by long-term @entity158 release and disability reduction obtained in all @entity1 was most probably the result of @entity3574 . The correction of local @entity1513 had no influence on the outcome.

title: @entity661 in the treatment of painful vertebral compression fractures: Effect on local @entity1513 and one-year outcomes in XXXX and disability.

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: BACKGROUND: The study aimed at estimating the effect of body mass index (BMI), used to classify @entity28 , @entity28 , and morbidly @entity28 @entity1 , on clinical outcomes in total laparoscopic hysterectomy (TLH) cases. METHODS: This retrospective cohort study included 153 @entity1 who underwent TLH for benign, premalignant, or malignant conditions between August 2010 and June 2013. @entity1 were divided into 3 groups according to BMI, and the following variables were analyzed: operation time, conversion rate, @entity190 , total complications, and length of hospital stay. RESULTS: The mean BMI was 33.5 kg/m(2) (range, 22-61). Forty-four @entity1 were @entity28 (BMI <30), 73 were @entity28 (30 <= BMI <40), and 36 were morbidly @entity28 (BMI >= 40). In 138 @entity1 (90.2%), hysterectomy was performed using an endoscopic technique. The rate of conversion to laparotomy (9.8%; 95% confidence interval (CI), 5.1-14.5), @entity190 (70.5 ml; range, 10-700), total complications (5.9%), and length of hospital stay (2.9 d; range, 1-8) did not vary according to BMI. Operation time was longer in @entity28 (p = 0.003) and morbidly @entity28 (0.002) @entity1 than in @entity28 @entity1 . CONCLUSION: TLH could be considered a safe and feasible alternative to abdominal hysterectomy in @entity28 and morbidly @entity28 @entity1 .    2015 S. Karger AG, Basel.

title: Total Laparoscopic Hysterectomy in Obese and Morbidly Obese XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'non-obese']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: AIM: To assess the clinical features and outcome of @entity706 when associated with @entity370 and to determine whether this association gives @entity706 a better prognosis. DESIGN: Multicentre retrospective cohort study. METHODS: Retrospective chart review. RESULTS: Twenty-one @entity1 were included (9 males, 12 females). Median age at @entity370 diagnosis was 48 years (range: 24-68 years). In 14 cases, @entity706 occurred within a previously known @entity370 . Five @entity1 received a concomitant diagnosis of @entity370 and @entity706 , whereas @entity706 preceded @entity370 in two @entity1 . Three @entity1 were diagnosed with @entity978 and 18 @entity1 with @entity1893 ( @entity1892 ( @entity1892 ) (n = 11), @entity706 (n = 2), @entity1072 /small @entity1072 (n = 2), anaplastic large cell @entity706 ALK + (n = 1), angioimmunoblastic @entity784 (n = 1) and @entity6444 (n = 1)). Thirteen @entity1 were alive and in complete remission. Median age at the time of diagnosis of @entity370 was lower in @entity1 with @entity706 compared with @entity1 with @entity370 preceding @entity706 (34 years vs. 51 years, P = 0.01). @entity1 presenting with @entity1892 associated with @entity370 were compared with @entity1892 without @entity370 . No statistical difference was found in the risk of @entity204 or progression between the two groups (P = 0.685). CONCLUSIONS: We report here the largest series of @entity706 associated @entity370 @entity1 . As opposed to previous studies, we observed a predominance of @entity1 with @entity1892 . Our study confirms the concept of the @entity706 . Large @entity1892 does not have a better prognosis when associated with @entity370 .

title: XXXX and @entity706 : a comparative study.

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'concomitant lymphoma', 'sarcoidosis-lymphoma syndrome', 'follicular lymphoma']

entities_list: @entity784 :: ('MESH:D016399', 'Disease') :: ['T-cell lymphoma']

entities_list: @entity1072 :: ('MESH:D015451', 'Disease') :: ['lymphocytic lymphoma', 'chronic lymphocytic leukemia']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'B-cell lymphoma', 'diffuse large B-cell lymphoma']

entities_list: @entity6444 :: ('MESH:D015461', 'Disease') :: ['T-cell prolymphocytic leukemia']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma"]

entities_list: @entity370 :: ('MESH:D012507', 'Disease') :: ['sarcoidosis']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ["Hodgkin's lymphoma"]

answer: @entity370 :: (MESH:D012507,Disease) :: ['Sarcoidosis']


abstract: AIM: To assess the clinical features and outcome of @entity706 when associated with @entity370 and to determine whether this association gives @entity706 a better prognosis. DESIGN: Multicentre retrospective cohort study. METHODS: Retrospective chart review. RESULTS: Twenty-one @entity1 were included (9 males, 12 females). Median age at @entity370 diagnosis was 48 years (range: 24-68 years). In 14 cases, @entity706 occurred within a previously known @entity370 . Five @entity1 received a concomitant diagnosis of @entity370 and @entity706 , whereas @entity706 preceded @entity370 in two @entity1 . Three @entity1 were diagnosed with @entity978 and 18 @entity1 with @entity1893 ( @entity1892 ( @entity1892 ) (n = 11), @entity706 (n = 2), @entity1072 /small @entity1072 (n = 2), anaplastic large cell @entity706 ALK + (n = 1), angioimmunoblastic @entity784 (n = 1) and @entity6444 (n = 1)). Thirteen @entity1 were alive and in complete remission. Median age at the time of diagnosis of @entity370 was lower in @entity1 with @entity706 compared with @entity1 with @entity370 preceding @entity706 (34 years vs. 51 years, P = 0.01). @entity1 presenting with @entity1892 associated with @entity370 were compared with @entity1892 without @entity370 . No statistical difference was found in the risk of @entity204 or progression between the two groups (P = 0.685). CONCLUSIONS: We report here the largest series of @entity706 associated @entity370 @entity1 . As opposed to previous studies, we observed a predominance of @entity1 with @entity1892 . Our study confirms the concept of the @entity706 . Large @entity1892 does not have a better prognosis when associated with @entity370 .

title: @entity370 and XXXX : a comparative study.

answer: @entity706 :: (MESH:D008223,Disease) :: ['lymphoma']


abstract: BACKGROUND AND PURPOSE: Aneurysm progression and @entity397 is thought to be governed by progressive degradation and weakening of the wall in response to abnormal hemodynamics. Our goal was to investigate the relationship between the intra-aneurysmal hemodynamic conditions and wall mechanical properties in @entity1 @entity439 . MATERIALS AND METHODS: A total of 8 unruptured @entity439 were analyzed. Computational fluid dynamics models were constructed from preoperative 3D rotational angiography images. The @entity439 were clipped, and the domes were resected and mechanically tested to failure with a uniaxial testing system under multiphoton microscopy. Linear regression analysis was performed to explore possible correlations between hemodynamic quantities and the failure characteristics and stiffness of the wall. RESULTS: The ultimate strain was correlated negatively to @entity439 rate (P = .021), mean velocity (P = .025), and mean wall shear stress (P = .039). It was also correlated negatively to inflow concentration, oscillatory shear index, and measures of the complexity and instability of the flow; however, these trends did not reach statistical significance. The wall stiffness at high strains was correlated positively to inflow rate (P = .014), mean velocity (P = .008), inflow concentration (P = .04), flow instability (P = .006), flow complexity (P = .019), wall shear stress (P = .002), and oscillatory shear index (P = .004). CONCLUSIONS: In a study of 8 unruptured @entity438 , ultimate strain was correlated negatively with @entity439 rate, mean velocity, and mean wall shear stress. Wall stiffness was correlated positively with @entity439 rate, mean velocity, wall shear stress, flow complexity and stability, and oscillatory shear index. These trends and the impact of hemodynamics on wall structure and mechanical properties should be investigated further in larger studies.

title: Wall Mechanical Properties and Hemodynamics of Unruptured XXXX .

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm inflow']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['intracranial aneurysms']

answer: @entity438 :: (MESH:D002532,Disease) :: ['Intracranial Aneurysms']


abstract: DNA analysis can reveal the origins and dispersal patterns of invasive species. The @entity16514 @entity16514 is one such alien animal, which has been dispersed widely by @entity1 from its native North America to many Pacific Ocean islands. In the Ogasawara (Bonin) Islands, this anole was recorded from Chichi-jima at the end of the 1960s, and then from Haha-jima in the early 1980s. These two islands are inhabited. In 2013, it was also found on the uninhabited Ani-jima, close to Chichi-jima. @entity1 are thought to have introduced the anole to Haha-jima, while the mode of introduction to Ani-jima is unknown. To clarify its dispersal patterns within and among these three islands, we assessed the fine-scale population genetic structure using five microsatellite loci. The results show a homogeneous genetic structure within islands, but different @entity74 among islands, suggesting that limited gene flow occurs between islands. The recently established Ani-jima population may have originated from several individuals simultaneously, or by repeated immigration from Chichi-jima. We must consider frequent incursions among these islands to control these invasive lizard populations and prevent their negative impact on native biodiversity.

title: Microsatellite Analysis of the Population Genetic Structure of XXXX Introduced to the Ogasawara Islands.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'Humans']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['genetic structures']

entities_list: @entity16514 :: ('28377', 'Species') :: ['green anole', 'Anolis carolinensis']

answer: @entity16514 :: (28377,Species) :: ['Anolis carolinensis']


abstract: OBJECTIVES: The purpose of this study was to evaluate the usefulness of MRI-guidance for core decompression of @entity2530 of the @entity2738 . MATERIALS AND METHODS: Twelve MRI-guided core decompressions were performed on @entity1 with different stages of @entity2530 of the @entity2738 . The @entity1 were asked to evaluate their @entity158 and their ability to function before and after the procedure and imaging findings were reviewed respectively. RESULTS: Technical success in reaching the target was 100  % without complications. Mean duration of the procedure itself was 54  min. All @entity1 with ARCO stage 1 @entity2530 experienced clinical benefit and pathological MRI findings were seen to diminish. @entity1 with more @entity1442 gained less, if any, benefit and total hip arthroplasty was eventually performed on four @entity1 . CONCLUSIONS: MRI-guidance seems technically feasible, accurate and safe for core decompression of @entity2530 of the @entity2738 . @entity1 with early stage @entity2530 may benefit from the procedure. KEY POINTS:     MRI is a useful guidance method for minimally invasive musculoskeletal interventions.     Bone drilling seems beneficial at early stages of @entity2530 .     MRI-guidance is safe and accurate for @entity79 .

title: MRI-guidance in percutaneous core decompression of @entity2530 of the XXXX .

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone drilling']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced disease']

entities_list: @entity2738 :: ('MESH:D005271', 'Disease') :: ['femoral head']

entities_list: @entity2530 :: ('MESH:D010020', 'Disease') :: ['osteonecrosis', 'avascular necrosis']

answer: @entity2738 :: (MESH:D005271,Disease) :: ['femoral head']