abstract: UNASSIGNED: @entity3089 ( @entity3090 ) is a major @entity3978 component of green tea (Camellia sinensis) and demonstrates anti-oxidant, anticancer and anti-inflammatory properties. @entity3090 has been shown to protect @entity989 ( @entity989 ) against oxidative stress-induced cell death. The pathogenesis of diseases in the retina is usually initiated by local @entity32 at the @entity989 cell layer, and @entity32 is mostly associated with leukocyte migration and the secretion of pro-inflammatory cytokines. Whether @entity3090 can modulate the cytokine-induced inflammatory response of @entity989 , particularly leukocyte migration, has not been clearly elucidated, and was therefore the objective of this study. @entity1 cells were cultured with different concentrations of @entity310 in the presence or absence of @entity3090 to different time points. Intracellular reactive @entity26 species (ROS) levels were determined. @entity2071 and phosphor-NF-kB and IkB expression were determined by Western blot analysis. Phosphor-NF-kB nuclear translocation and monocyte- @entity989 adhesion were investigated using immunofluorescence confocal laser scanning microscopy. Scanning electron microscopy (SEM) was carried out to further determine the ultrastructure of monocyte- @entity989 adhesion. The results demonstrated that @entity310 modulated inflammatory effects in ARPE-19 by induction of ROS and up-regulation of @entity2071 expression. Moreover, @entity310 -induced phosphor-NF-kB nuclear translocation, increased phosphor-NF-kB expression and IkB degradation, and increased the degree of monocyte- @entity989 adhesion. Pretreating the cells with @entity3090 ameliorated the inflammatory effects of @entity310 . The results indicated that @entity3090 significantly exerts anti-inflammatory effects in @entity1 cells, partly as a suppressor of @entity310 signaling and that the inhibition was mediated via the NF-kB pathway.

title: Green Tea @entity3978 XXXX Attenuates @entity310 -Induced Intercellular Adhesion Molecule-1 Expression and Monocyte Adhesion to Retinal Pigment Epithelial Cells.

answer: @entity3089 :: (MESH:C045651,Chemical) :: ['Epigallocatechin-3-Gallate']


abstract: AIM: This study investigates the colonization rate of @entity30811 in the gastrointestinal tracts of @entity1 living in southern China and applies a modified method for the isolation and subtyping of A.  muciniphila strains from faecal samples. METHODS AND RESULTS: Fresh faecal samples were collected and bacterial DNA was extracted from these samples for real-time PCR analysis. Strains were separated using a culture-dependent sPCR-directed method and classified using an enterobacterial repetitive intergenic consensus (ERIC-PCR) DNA fingerprinting method. The colonization rate for the sample population from southern China was 51  74%. We isolated 22 strains from @entity1 faeces. The results revealed that all strains were identifiable as A.  muciniphila with 99-100% identity to the type-strain @entity30811 . ERIC-PCR resulted in grouping of the DNA fingerprints showed that 12 distinct clusters were distinguished with a delineation level of 100%. CONCLUSIONS: Southern China has a high rate of A.  muciniphila colonization and over 12 different subtype strains reside in faecal samples. SIGNIFICANCE AND IMPACT OF THE STUDY: @entity30811 has a beneficial role in @entity1 gastrointestinal tract. These studies provide a better understanding of A.  muciniphila and details of its colonization in the @entity1 gastrointestinal tract.

title: Different subtype strains of XXXX abundantly colonize in southern China.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'people']

entities_list: @entity30811 :: ('239935', 'Species') :: ['Akkermansia muciniphila', 'ATCC BAA-835']

answer: @entity30811 :: (239935,Species) :: ['Akkermansia muciniphila']


abstract: BACKGROUND: The American College of Emergency Physicians and the American Society of Clinical Oncology recommend early palliative care consultation for @entity1 with advanced, life-limiting illnesses, such as @entity5 . OBJECTIVES: The objectives were to assess the process of early referral from the emergency department (ED) to palliative care for @entity1 with advanced, incurable @entity5 as part of a randomized controlled trial and to compare the proportion and timing of consultation to a care as usual group. METHODS: A single-blind randomized controlled trial (ClinicalTrials.gov ID NCT01358110) compared early, ED-based referrals to palliative care for @entity1 admitted with advanced, incurable @entity5 to physician-driven consultation (i.e., care as usual). @entity1 had to speak English or Spanish and have no history of palliative care consultation. They were randomized via @entity616 randomization to the intervention or control group. Each intervention subject was referred by a research staff member to the palliative care team for consultation. The usual care group received palliative care only if requested by the admitting physician. Analysis was based on intention to treat. A chart review was performed to assess proportion and timing of palliative care consults during the index admission, defined as: 1) completed palliative care consult documented in the chart and 2) days from admission to palliative care consult. RESULTS: A total of 134 @entity1 were enrolled and randomized. For @entity1 in the intervention group, 88% (60 of 68) had documented palliative care consultations during their index admissions (95% confidence interval [CI]  =  80.5 to 95.5), compared to 18% (12 of 66) in the control group (95% CI  =  8.8 to 27.5; p < 0.01). The 60 intervention @entity1 received palliative care consultations on average 1.48  days from admission (95% CI  =  1.19 to 1.76), compared to 2.9  days from admission in the 12 control @entity1 (95% CI  =  1.03 to 4.79; p  =  0.15). CONCLUSIONS: This study documented a low baseline rate of palliative care involvement as part of usual care in @entity1 with @entity5 being admitted from the ED. Early referral to palliative care in the context of a research study significantly increased the likelihood that @entity1 received a consult, thus meriting further investigation of how to generalize this approach.

title: Emergency Department-triggered Palliative Care in XXXX : Proof of Concept.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'metastatic cancer', 'advanced cancer']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['balanced block']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Advanced Cancer']


abstract: Wnt antagonism has been linked to @entity726 and intraocular pressure regulation, as has increased stiffness of @entity1 trabecular meshwork (HTM) tissue. We have shown culturing HTM cells on substrates that mimic the elevated stiffness of glaucomatous tissue leads to elevated expression of the Wnt antagonist @entity12393 ( @entity12393 ), suggesting a linkage between @entity12393 and HTM mechanobiology. In this study, we document biomechanical consequences of Wnt antagonism on HTM cells. Cells were treated with the Wnt antagonists ( @entity12393 , @entity71487 , and LGK-974) for 8 days and allowed to recover for 4 days. After recovery, intrinsic cell stiffness and activation of the Wnt pathway via @entity3546 staining and blotting were assayed. Basal cell stiffness values were 3.71      0.37, 4.33      3.07, and 3.07      kPa (median      S.D.) for cells derived from 3 donors. Cell stiffness increased after 0.25   g/mL (4.32      5.12, 8.86      8.51, 4.84      3.15  kPa) and 0.5   g/mL (16.75      5.59, 13.18      7.99, and 8.54      5.77  kPa) @entity12393 treatment. Stiffening was observed after 10   M @entity71487 (10.72      5.63 and 6.57      5.53  kPa) as well as LGK-974 (9.60      7.41 and 11.40      9.24  kPa) treatment compared with controls (3.79      1.01 and 5.16      2.14  kPa). Additionally, Wnt inhibition resulted in decreased @entity3546 staining and increased phosphorylation at @entity1889 41 after recovery. In conclusion, this work demonstrates a causal relationship between Wnt inhibition and cell stiffening. Additionally, these findings suggest transient Wnt inhibition resulted in durable modulation of the mechanical phenotype of HTM cells. When placed in context with previous results, these findings provide a causal link between Wnt antagonism and cell stiffness and suggest a feedback loop contributing to @entity726 progression.

title: Wnt inhibition induces persistent increases in intrinsic stiffness of XXXX trabecular meshwork cells.

entities_list: @entity12393 :: ('6422', 'Gene') :: ['SFRP1', 'secreted frizzled related protein 1']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity1889 :: ('CHEBI:26986', 'Chemical') :: ['threonine']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: Mutations in the nucleophosmin ( @entity8102 ) gene have been used as molecular biomarkers for prognostication of @entity1 with adult @entity3052 ( @entity3052 ). METHODS: We designed a rapid and sensitive method using the allele-specific-refractory mutation system-polymerase chain reaction (ARMS-PCR) to detect the most common mutations of @entity8102 gene, which are mostly four base pair insertions and compared its efficacy with direct sequencing and capillary electrophoresis which served as the gold standards. RESULTS: The incidence of mutation was 22% (33% of @entity1 with normal karyotypes had mutation compared with 16% of @entity1 with abnormal karyotypes) based on the results obtained with capillary electrophoresis analysis and direct sequencing. All of the specimens determined to be mutation-positive by the gold standard tests were also positive by the ARMS-PCR method. Significantly, the ARMS-PCR test also helped determine the mutation status of an extra set of @entity1 who had low call rates on capillary electrophoresis and appeared normal on direct sequencing. DISCUSSION: The low mutation rate in some @entity1 hindered its detection in the gold standard assays because of the interference of the mutation signal by high background noise. The low sensitivity of the gold standard assays for detecting low copy number mutations rates thus increase their risk of producing false negative results that adversely affects prognostication and therapy. Our results suggest that the mutation detection rate of the ARMS-PCR assay is better than existing tests. This is most probably because of the fact that in an ARMS-PCR-based method, the mutated variant is specifically amplified, based on a mutation-specific primer. CONCLUSIONS: We conclude that the high sensitivity of the ARMS-based method together with its rapidity and low expense should make it a suitable choice for clinical laboratories.

title: XXXX Mutation Detection in Acute Myeloid Leukemia: A Method Comparison Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

answer: @entity8102 :: (4869,Gene) :: ['NPM1']


abstract: BACKGROUND: The prevalence of @entity28 and the female labor participation rate have been rapidly increasing in South Korea. To examine the relationship between these factors, we investigated the association between timing and type of work and @entity28 in the Korean female working population. METHODS: Data collected by the 2008 @entity497 ( @entity497 ) were analyzed using a complex, stratified, multistage, probability cluster sampling method. Descriptive analysis of relevant variables was performed using the chi-square test, and work-related variables by work type were identified using multivariate logistic regression. The relationship between long working hours, night/shift work, and body-mass index in female workers and explanatory, stratifying, and dependent variables and covariates was analyzed using multiple logistic regression models. RESULTS: A total of 42,234 @entity497 @entity1 were eligible for study inclusion. Among both manual and nonmanual workers, working less than 40 (adjusted odds ratio [aOR] 1.18, 95% confidence interval [CI] 1.07-1.31 and aOR 1.29; 95% CI 1.09-0.52, respectively) or more than 60 (aOR 1.18, 95% CI 1.06-1.30 and aOR 1.28, 95% CI 1.04-1.57, respectively) hours per week was significantly associated with @entity28 after controlling for covariates. However, working type (day or night/shift) was significantly associated with @entity28 only in nonmanual workers (aOR 1.20, 95% CI 1.01-1.42). When we controlled working type in the model, manual workers who work more than 60 hours show higher likelihood of being @entity28 ( @entity32926 , 95% CI 1.02-1.18). CONCLUSION: Working fewer (<40) or more than (>60) hours per week is significantly associated with @entity28 in the Korean female working population, regardless of the type of work. The type of work (day vs. night/shift work) was significantly associated with @entity28 only in only nonmanual workers.

title: Do Working Hours and Type of Work Affect Obesity in South Korean Female Workers? Analysis of the Korean XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity497 :: ('MESH:D003147', 'Disease') :: ['CHS', 'Community Health Survey']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

answer: @entity497 :: (MESH:D003147,Disease) :: ['Community Health Survey']


abstract: UNASSIGNED: @entity360 from @entity1066 or esophago-gastric varices are life threatening medical conditions which require immediate endoscopic therapy. Despite successful endoscopic hemostasis, there is a significant risk of rebleeding often requiring close surveillance of these @entity1 in the intensive care unit (ICU). Any time delay to recognize @entity548 may lead to a high @entity190 and increases the risk of @entity204 . A novel telemetric real-time @entity548 sensor can help indicate blood in the stomach: the sensor is swallowed to detect active @entity548 or is anchored endoscopically on the gastrointestinal wall close to the potential @entity548 source. By telemetric communication with an extra-corporeal receiver, information about the @entity548 status is displayed. In this study the novel sensor, which measures characteristic optical properties of blood, has been evaluated in an ex-vivo setting to assess its clinical applicability and usability. @entity1 venous blood of different concentrations, various fluids, and liquid food were tested. The LED-based sensor was able to reliably distinguish between concentrated blood and other liquids, especially red-colored fluids. In addition, the spectrometric quality of the small sensor (size: 6.5mm in diameter, 25.5mm in length) was comparable to a much larger and technically more complex laboratory spectrophotometer. The experimental data confirm the capability of a miniaturized sensor to identify concentrated blood, which could help in the very near future the detection of upper @entity360 and to survey high-risk @entity1 for rebleeding.

title: Telemetric real-time sensor for the detection of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Human']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding', 'Acute upper gastrointestinal bleedings']

answer: @entity360 :: (MESH:D006471,Disease) :: ['acute upper gastrointestinal bleeding']


abstract: BACKGROUND: Early/intensive mobilization may improve functional recovery after @entity64 but it is not clear which kind of "mobilization" is more effective. Proprioceptive neuromuscular facilitation (PNF) and @entity73 ( @entity73 ) are widespread applied in post- @entity64 rehabilitation but their efficacy and safety have not been systematically investigated. AIM: To compare PNF and @entity73 methods in a two different time setting (early versus standard approach) in order to evaluate different role of time and techniques in functional recovery after acute @entity385 . DESIGN: We designed a prospectical multicenter blinded interventional study of early versus standard approach with two different methods by means of both PNF and @entity73 . SETTING: A discrete @entity64 -dedicated area for out-of-thrombolysis @entity1 , connected with two different @entity64 centres in two different catchment areas. POPULATION: Three hundred and forty consecutive @entity64 @entity1 with first ever sub-cortical @entity385 in the mean cerebral artery (MCA) territory and contralateral @entity1158 admitted within 6 and 24 hours from symptoms onset. METHODS: All @entity1 were randomly assigned by means of a computer generated randomization sequence in blocks of 4 to one to the 4 interventional groups: early versus delayed rehabilitation programs with Kabat's schemes or Perfetti's technique. @entity1 in both delayed group underwent to a standard protocol in the acute phase. PRIMARY OUTCOME: disability at 3-12 months. Disability measures: modified Rankin Score and Barthel Index. Safety outcome: immobility-related adverse events. SECONDARY OUTCOME MEASURES: Six-Minute Walking Test, Motricity Index, Mini-Mental State Examination, Beck @entity308 Inventory. RESULTS: Disability was not different between groups at 3 months but Barthel Index significantly changed between early versus delayed groups at 12 months (P=0.01). Six-Minute Walking Test (P=0.01) and Motricity Index in both upper (P=0.01) and lower limbs (P=0.001) increased in early versus delayed groups regardless rehabilitation schedule. CONCLUSIONS: A time-dependent effect of rehabilitation on post @entity64 motor recovery was observed, particularly in lower limb improvement. According to our results, rehabilitation technique seems not to affect long term motor recovery. CLINICAL REHABILITATION IMPACT: These results show a significant effect of time but not of technique that may impact the decision making in the acute phase of care.

title: Early versus delayed rehabilitation treatment in hemiplegic @entity1 with @entity385 : proprioceptive or XXXX ?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1158 :: ('MESH:D006429', 'Disease') :: ['hemiplegia']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['comprehensive stroke', 'stroke']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['CTE', 'cognitive therapeutic exercise']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity73 :: (MESH:D003072,Disease) :: ['cognitive approach']


abstract: BACKGROUND: Early/intensive mobilization may improve functional recovery after @entity64 but it is not clear which kind of "mobilization" is more effective. Proprioceptive neuromuscular facilitation (PNF) and @entity73 ( @entity73 ) are widespread applied in post- @entity64 rehabilitation but their efficacy and safety have not been systematically investigated. AIM: To compare PNF and @entity73 methods in a two different time setting (early versus standard approach) in order to evaluate different role of time and techniques in functional recovery after acute @entity385 . DESIGN: We designed a prospectical multicenter blinded interventional study of early versus standard approach with two different methods by means of both PNF and @entity73 . SETTING: A discrete @entity64 -dedicated area for out-of-thrombolysis @entity1 , connected with two different @entity64 centres in two different catchment areas. POPULATION: Three hundred and forty consecutive @entity64 @entity1 with first ever sub-cortical @entity385 in the mean cerebral artery (MCA) territory and contralateral @entity1158 admitted within 6 and 24 hours from symptoms onset. METHODS: All @entity1 were randomly assigned by means of a computer generated randomization sequence in blocks of 4 to one to the 4 interventional groups: early versus delayed rehabilitation programs with Kabat's schemes or Perfetti's technique. @entity1 in both delayed group underwent to a standard protocol in the acute phase. PRIMARY OUTCOME: disability at 3-12 months. Disability measures: modified Rankin Score and Barthel Index. Safety outcome: immobility-related adverse events. SECONDARY OUTCOME MEASURES: Six-Minute Walking Test, Motricity Index, Mini-Mental State Examination, Beck @entity308 Inventory. RESULTS: Disability was not different between groups at 3 months but Barthel Index significantly changed between early versus delayed groups at 12 months (P=0.01). Six-Minute Walking Test (P=0.01) and Motricity Index in both upper (P=0.01) and lower limbs (P=0.001) increased in early versus delayed groups regardless rehabilitation schedule. CONCLUSIONS: A time-dependent effect of rehabilitation on post @entity64 motor recovery was observed, particularly in lower limb improvement. According to our results, rehabilitation technique seems not to affect long term motor recovery. CLINICAL REHABILITATION IMPACT: These results show a significant effect of time but not of technique that may impact the decision making in the acute phase of care.

title: Early versus delayed rehabilitation treatment in hemiplegic @entity1 with XXXX : proprioceptive or @entity73 ?

answer: @entity385 :: (MESH:D002544,Disease) :: ['ischemic stroke']


abstract: BACKGROUND: Early/intensive mobilization may improve functional recovery after @entity64 but it is not clear which kind of "mobilization" is more effective. Proprioceptive neuromuscular facilitation (PNF) and @entity73 ( @entity73 ) are widespread applied in post- @entity64 rehabilitation but their efficacy and safety have not been systematically investigated. AIM: To compare PNF and @entity73 methods in a two different time setting (early versus standard approach) in order to evaluate different role of time and techniques in functional recovery after acute @entity385 . DESIGN: We designed a prospectical multicenter blinded interventional study of early versus standard approach with two different methods by means of both PNF and @entity73 . SETTING: A discrete @entity64 -dedicated area for out-of-thrombolysis @entity1 , connected with two different @entity64 centres in two different catchment areas. POPULATION: Three hundred and forty consecutive @entity64 @entity1 with first ever sub-cortical @entity385 in the mean cerebral artery (MCA) territory and contralateral @entity1158 admitted within 6 and 24 hours from symptoms onset. METHODS: All @entity1 were randomly assigned by means of a computer generated randomization sequence in blocks of 4 to one to the 4 interventional groups: early versus delayed rehabilitation programs with Kabat's schemes or Perfetti's technique. @entity1 in both delayed group underwent to a standard protocol in the acute phase. PRIMARY OUTCOME: disability at 3-12 months. Disability measures: modified Rankin Score and Barthel Index. Safety outcome: immobility-related adverse events. SECONDARY OUTCOME MEASURES: Six-Minute Walking Test, Motricity Index, Mini-Mental State Examination, Beck @entity308 Inventory. RESULTS: Disability was not different between groups at 3 months but Barthel Index significantly changed between early versus delayed groups at 12 months (P=0.01). Six-Minute Walking Test (P=0.01) and Motricity Index in both upper (P=0.01) and lower limbs (P=0.001) increased in early versus delayed groups regardless rehabilitation schedule. CONCLUSIONS: A time-dependent effect of rehabilitation on post @entity64 motor recovery was observed, particularly in lower limb improvement. According to our results, rehabilitation technique seems not to affect long term motor recovery. CLINICAL REHABILITATION IMPACT: These results show a significant effect of time but not of technique that may impact the decision making in the acute phase of care.

title: Early versus delayed rehabilitation treatment in hemiplegic XXXX with @entity385 : proprioceptive or @entity73 ?

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: Ruminants remain productive during the @entity1887 or early lactation by evoking metabolic adaptations sparing available energy and nutrients (e.g. higher metabolic efficiency and induction of insulin resistance). A deficit in central leptin signaling triggers these adaptations in rodents but whether it does in ruminants remains unclear. To address this issue, five mature ewes were implanted with intracerebroventricular (ICV) cannula in the third ventricle. They were used in two experiments with an ovine leptin antagonist (OLA) when well-conditioned (average body condition score of 3.7 on a 5 point scale). The first experiment tested the ability of OLA to antagonize leptin under in vivo conditions. Ewes received continuous ICV infusion of artificial cerebrospinal fluid (aCSF), ovine leptin (4   g/h) or the combination of ovine leptin (4   g/h) and its mutant version OLA (40   g/h) for 48 h. Dry matter intake (DMI) was measured every day and blood samples were collected on the last day of infusion. ICV infusion of leptin reduced DMI by 24% (P < 0.05), and this effect was completely abolished by OLA co-infusion. A second experiment tested whether a reduction in endogenous leptin signaling in the brain triggers metabolic adaptations. This involved continuous ICV infusions of aCSF or OLA alone (40   g/h) for 4 consecutive days. The infusion of OLA did not alter voluntary DMI over the treatment period or on any individual day. OLA did not affect plasma variables indicative of insulin action ( @entity413 , non-esterified @entity1718 , insulin and the disposition of plasma @entity413 during an insulin tolerance test) or plasma @entity701 , but tended to reduce plasma @entity1954 and @entity1955 (P < 0.07). Overall, these data show that a reduction of central leptin signaling has little impact on insulin action in well-conditioned mature @entity742 . They also raise the possibility that reduced central leptin signaling plays a role in controlling @entity6145 production.

title: Insensitivity of well-conditioned mature XXXX to central administration of a leptin receptor antagonist.

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['energy insufficiency of late pregnancy']

entities_list: @entity1955 :: ('MESH:D013974', 'Chemical') :: ['thyroxine']

entities_list: @entity6145 :: ('CHEBI:60311', 'Chemical') :: ['thyroid hormone']

entities_list: @entity701 :: ('MESH:D006854', 'Chemical') :: ['cortisol']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity1954 :: ('MESH:D014284', 'Chemical') :: ['triiodothyronine']

answer: @entity742 :: (9940,Species) :: ['sheep']


abstract: AIMS: Psychopathology has been studied in @entity1 with @entity302 or @entity302 in the context of diagnosis and treatment. Unfortunately, most PNES studies include few males and do not consider possible gender differences, making findings less generalizable to males with PNES. In this study we specifically compare males with PNES to females with PNES and to males with @entity302 . METHODS: Males with PNES (n=58), males with @entity302 (n=86), females with PNES (n=147), and females with @entity2828 (n=142) were evaluated on an inpatient @entity302 monitoring unit. Self-reported objective measures of psychopathology, demographics, and PNES @entity410 semiology were compared. RESULTS: Personality Assessment Inventory profiles revealed marked differences, particularly in somatic symptoms, between PNES and @entity302 . Females with PNES had higher levels of physiological @entity308 but lower antisocial features. Males with PNES who had clinically significant elevations on the somatic complaints scale were much more likely to have motor @entity410 while females with PNES classified similarly were equally likely to have either motor or non-motor events. CONCLUSION: Gender difference in PNES @entity410 semiology was associated with whether or not clinically significant somatic symptoms were present; males with elevated somatic symptoms were much more likely to have motor PNES. However, we did not find evidence of greater psychopathology in males with PNES compared to females with PNES. Gender differences in the behavioral manifestation of PNES in the context of presence or absence of somatization may have implications for diagnosis and treatment.

title: XXXX semiology in males with psychogenic @entity410 is associated with somatic complaints.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive symptoms']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic', 'epilepsy', 'psychogenic non-epileptic seizures']

answer: @entity410 :: (MESH:D012640,Disease) :: ['Seizure']


abstract: AIMS: Psychopathology has been studied in @entity1 with @entity302 or @entity302 in the context of diagnosis and treatment. Unfortunately, most PNES studies include few males and do not consider possible gender differences, making findings less generalizable to males with PNES. In this study we specifically compare males with PNES to females with PNES and to males with @entity302 . METHODS: Males with PNES (n=58), males with @entity302 (n=86), females with PNES (n=147), and females with @entity2828 (n=142) were evaluated on an inpatient @entity302 monitoring unit. Self-reported objective measures of psychopathology, demographics, and PNES @entity410 semiology were compared. RESULTS: Personality Assessment Inventory profiles revealed marked differences, particularly in somatic symptoms, between PNES and @entity302 . Females with PNES had higher levels of physiological @entity308 but lower antisocial features. Males with PNES who had clinically significant elevations on the somatic complaints scale were much more likely to have motor @entity410 while females with PNES classified similarly were equally likely to have either motor or non-motor events. CONCLUSION: Gender difference in PNES @entity410 semiology was associated with whether or not clinically significant somatic symptoms were present; males with elevated somatic symptoms were much more likely to have motor PNES. However, we did not find evidence of greater psychopathology in males with PNES compared to females with PNES. Gender differences in the behavioral manifestation of PNES in the context of presence or absence of somatization may have implications for diagnosis and treatment.

title: @entity410 semiology in males with psychogenic XXXX is associated with somatic complaints.

answer: @entity410 :: (MESH:D012640,Disease) :: ['nonepileptic seizures']


abstract: INTRODUCTION: Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying @entity1 as to whether they will respond or not to a given treatment before prescription is not only essential to optimise treatment outcome but also to lessen the economic burden that such drugs can have on healthcare resources. In @entity309 ( @entity309 ), there is of yet no genetic/genomic biomarker which can accurately predict response to @entity310 inhibitor biologics prior to treatment, despite much interest in this area. Multiple studies have reported findings on potential candidate genes; however, due to relatively small sample sizes or lack of sufficient validation, results have been disappointingly inconsistent. The aim of this research was to further explore the predictive value of a previously reported association between @entity2935 expression and response to the @entity310 inhibitor biologics, adalimumab and etanercept. METHODS: Real-time qPCR was performed using whole blood RNA samples obtained from seventy-five @entity309 @entity1 about to commence treatment with a @entity310 inhibitor biologic drug, whose response status was determined at 3-month follow-up using the EULAR classification criteria. Relative quantification of @entity2935 using the comparative CT method outputted differential expression between good-responders and non-responders as a fold-change. RESULTS: Relative expression of @entity2935 in @entity1 receiving @entity310 inhibitor biologics yielded a decrease of 1.025 fold in good-responders as compared to non-responders (p-value = 0.36). Upon stratification of @entity1 dependent upon the specific drug administered, adalimumab or etanercept, similar findings to the full cohort were observed, decreases of 1.015 (p-value = 0.33) and 1.032 fold (p-value = 0.13) in good-responders compared to non-responders, respectively. CONCLUSION: The results from this study reveal that @entity2935 expression does not correlate with response to @entity310 inhibitor biologics when tested for within pre-treatment whole blood samples of @entity309 @entity1 .

title: Investigating @entity2935 expression as a potential genomic biomarker of response to XXXX inhibitor biologics in whole blood @entity309 samples.

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity310 :: (7124,Gene) :: ['TNF']


abstract: INTRODUCTION: Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying @entity1 as to whether they will respond or not to a given treatment before prescription is not only essential to optimise treatment outcome but also to lessen the economic burden that such drugs can have on healthcare resources. In @entity309 ( @entity309 ), there is of yet no genetic/genomic biomarker which can accurately predict response to @entity310 inhibitor biologics prior to treatment, despite much interest in this area. Multiple studies have reported findings on potential candidate genes; however, due to relatively small sample sizes or lack of sufficient validation, results have been disappointingly inconsistent. The aim of this research was to further explore the predictive value of a previously reported association between @entity2935 expression and response to the @entity310 inhibitor biologics, adalimumab and etanercept. METHODS: Real-time qPCR was performed using whole blood RNA samples obtained from seventy-five @entity309 @entity1 about to commence treatment with a @entity310 inhibitor biologic drug, whose response status was determined at 3-month follow-up using the EULAR classification criteria. Relative quantification of @entity2935 using the comparative CT method outputted differential expression between good-responders and non-responders as a fold-change. RESULTS: Relative expression of @entity2935 in @entity1 receiving @entity310 inhibitor biologics yielded a decrease of 1.025 fold in good-responders as compared to non-responders (p-value = 0.36). Upon stratification of @entity1 dependent upon the specific drug administered, adalimumab or etanercept, similar findings to the full cohort were observed, decreases of 1.015 (p-value = 0.33) and 1.032 fold (p-value = 0.13) in good-responders compared to non-responders, respectively. CONCLUSION: The results from this study reveal that @entity2935 expression does not correlate with response to @entity310 inhibitor biologics when tested for within pre-treatment whole blood samples of @entity309 @entity1 .

title: Investigating @entity2935 expression as a potential genomic biomarker of response to @entity310 inhibitor biologics in whole blood XXXX samples.

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: INTRODUCTION: Gene expression profiling is rapidly becoming a useful and informative tool in a much needed area of research. Identifying @entity1 as to whether they will respond or not to a given treatment before prescription is not only essential to optimise treatment outcome but also to lessen the economic burden that such drugs can have on healthcare resources. In @entity309 ( @entity309 ), there is of yet no genetic/genomic biomarker which can accurately predict response to @entity310 inhibitor biologics prior to treatment, despite much interest in this area. Multiple studies have reported findings on potential candidate genes; however, due to relatively small sample sizes or lack of sufficient validation, results have been disappointingly inconsistent. The aim of this research was to further explore the predictive value of a previously reported association between @entity2935 expression and response to the @entity310 inhibitor biologics, adalimumab and etanercept. METHODS: Real-time qPCR was performed using whole blood RNA samples obtained from seventy-five @entity309 @entity1 about to commence treatment with a @entity310 inhibitor biologic drug, whose response status was determined at 3-month follow-up using the EULAR classification criteria. Relative quantification of @entity2935 using the comparative CT method outputted differential expression between good-responders and non-responders as a fold-change. RESULTS: Relative expression of @entity2935 in @entity1 receiving @entity310 inhibitor biologics yielded a decrease of 1.025 fold in good-responders as compared to non-responders (p-value = 0.36). Upon stratification of @entity1 dependent upon the specific drug administered, adalimumab or etanercept, similar findings to the full cohort were observed, decreases of 1.015 (p-value = 0.33) and 1.032 fold (p-value = 0.13) in good-responders compared to non-responders, respectively. CONCLUSION: The results from this study reveal that @entity2935 expression does not correlate with response to @entity310 inhibitor biologics when tested for within pre-treatment whole blood samples of @entity309 @entity1 .

title: Investigating XXXX expression as a potential genomic biomarker of response to @entity310 inhibitor biologics in whole blood @entity309 samples.

answer: @entity2935 :: (3687,Gene) :: ['CD11c']


abstract: Serial assessment of cardiac function by radionuclide ejection fraction (EF), using a "first-pass" technique, was performed prior to each dose in 292 @entity1 receiving @entity632 . Detailed analysis was undertaken in 98 @entity1 , consisting of all 91 @entity1 who had received greater than 200 mg/m2 and seven with risk factors (RFs) who had received between 100 and 200 mg/m2. Thirty-two @entity1 had RFs and 66 had no risk factors (NRFs). RFs were: (a) @entity65 , (b) mediastinal irradiation within 6 months of starting @entity632 treatment, and (c) total @entity632 dose greater than 550 mg/m2. The criteria for discontinuing @entity632 were EF less than 0.40 in @entity6470 @entity1 or less than 0.35 in @entity37763 @entity1 or decrease in EF of greater than or equal to 0.14 over three successive readings. In the @entity37763 group, no @entity1 met these criteria nor did any develop @entity712 . In the @entity6470 group, discontinuation was indicated in eight @entity1 : two stopped receiving @entity632 at total doses of 730 mg/m2 and 680 mg/m2, respectively, and it was discontinued in the other six at total doses ranging from 120 to 420 mg/m2. Prior to the first dose of @entity632 , all @entity1 should have a baseline EF and assessment of RFs. An EF study is required before each subsequent dose in @entity1 with RFs or with initial EF less than 0.45, but in the remaining @entity1 , serial studies are not required until there is a cumulative dose of 450 mg/m2. Use of these guidelines and our criteria for discontinuation may prevent development of @entity632 @entity1370 .

title: Radionuclide ejection fraction in @entity632 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['cardiac failure']

entities_list: @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity1370 :: (MESH:D066126,Disease) :: ['cardiotoxicity']


abstract: Serial assessment of cardiac function by radionuclide ejection fraction (EF), using a "first-pass" technique, was performed prior to each dose in 292 @entity1 receiving @entity632 . Detailed analysis was undertaken in 98 @entity1 , consisting of all 91 @entity1 who had received greater than 200 mg/m2 and seven with risk factors (RFs) who had received between 100 and 200 mg/m2. Thirty-two @entity1 had RFs and 66 had no risk factors (NRFs). RFs were: (a) @entity65 , (b) mediastinal irradiation within 6 months of starting @entity632 treatment, and (c) total @entity632 dose greater than 550 mg/m2. The criteria for discontinuing @entity632 were EF less than 0.40 in @entity6470 @entity1 or less than 0.35 in @entity37763 @entity1 or decrease in EF of greater than or equal to 0.14 over three successive readings. In the @entity37763 group, no @entity1 met these criteria nor did any develop @entity712 . In the @entity6470 group, discontinuation was indicated in eight @entity1 : two stopped receiving @entity632 at total doses of 730 mg/m2 and 680 mg/m2, respectively, and it was discontinued in the other six at total doses ranging from 120 to 420 mg/m2. Prior to the first dose of @entity632 , all @entity1 should have a baseline EF and assessment of RFs. An EF study is required before each subsequent dose in @entity1 with RFs or with initial EF less than 0.45, but in the remaining @entity1 , serial studies are not required until there is a cumulative dose of 450 mg/m2. Use of these guidelines and our criteria for discontinuation may prevent development of @entity632 @entity1370 .

title: Radionuclide ejection fraction in XXXX @entity1370 .

answer: @entity632 :: (MESH:D004317,Chemical) :: ['doxorubicin']


abstract: BACKGROUND: @entity11163 ( @entity11163 ) are commonly used as adjunctive hormone treatment for early @entity0 @entity1 . The major side effect of @entity11163 is @entity4841 , which affects adherence. Previous reviews suggested that acupuncture is effective in the management of @entity5 . The aim of this review is to evaluate the effects of acupuncture on @entity4841 caused by @entity11163 . METHODS: This article examined @entity23 ( @entity23 ) measuring the effects of acupuncture on joint symptoms caused by @entity11163 within 8 medical databases till May 2014. The quality of the articles was evaluated according to the Cochrane risk of bias (ROB) tool. RESULTS: Four @entity23 were identified in medical journals. Two studies were conducted with manual acupuncture and 2 studies were electroacupuncture. The range of sample size was between 32 and 67. One RCT showed significant improvement in the acupuncture group compared with the sham control group and another RCT showed a statistical difference between the electroacupuncture and waitlist group. The other 2 studies showed no statistical differences between control and acupuncture groups. Two studies conducted blood analysis to elucidate the mechanism of efficacy of acupuncture for @entity4841 . The 2 positive studies had a lower ROB and 2 studies had a high ROB. CONCLUSIONS: The systematic review suggests that acupuncture has potential benefits to improve @entity4841 caused by @entity11163 . However, further trials of adequate sample size, appropriate control group, and longer follow-up are necessary to investigate the efficacy of acupuncture in AI-induced @entity4841 .

title: Acupuncture for Aromatase Inhibitor-Induced XXXX : A Systematic Review.

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer-related pain']

entities_list: @entity23 :: ('MESH:D007174', 'Disease') :: ['randomized controlled trials', 'RCTs']

entities_list: @entity11163 :: ('MESH:C537436', 'Disease') :: ['AIs', 'Aromatase inhibitors']

entities_list: @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia']

answer: @entity4841 :: (MESH:D018771,Disease) :: ['Arthralgia']


abstract: INTRODUCTION: @entity10979 , a radiopharmaceutical widely used in the assessment of myocardial perfusion, can be used as an indicator of @entity1374 due to its oncophilic character. The aim of this study was to establish the usefulness of performing additional examinations of radiotracer uptake in the thyroid gland during standard stress scintigraphy with sestamibi in order to identify @entity1374 . MATERIAL AND METHODS: After a retrospective evaluation of 330 consecutive myocardial perfusion scintigraphies performed in our hospital during one year, 41 @entity1 with a focal accumulation of @entity10979 in the thyroid were enrolled in the study. The @entity1 underwent clinical examinations, including thyroid ultrasonography and TSH, fT4, fT3, @entity4424 , TRAB, calcitonin, and @entity787 levels. Based on the thyroid ultrasounds, 21 @entity1 were referred for fine-needle aspiration biopsy of the thyroid. RESULTS: An abnormal accumulation of radiotracer in the thyroid was found in 41(12.4%) of 330 @entity1 who underwent stress cardiac scintigraphy. Thirteen (31.7%) of those @entity1 had multinodular euthyroid goitres, 12 (29.2%) had a single thyroid nodule (including two autonomous nodules), 11 (26.8%) had @entity1669 , and one (2.4%) had @entity3557 . In 12 (29.2%) with thyroid tracer uptake there was no thyroid pathology. CONCLUSIONS: Additional evaluation of radiotracer uptake in the thyroid during standard myocardial perfusion scintigraphy is a valuable tool in the detection of @entity1374 . The additional or parallel evaluation of radiotracer uptake in the thyroid should be considered during every @entity296 . (Endokrynol Pol 2015; 66 (6): 521-525).

title: Incidentally recognised thyroid focal uptake of XXXX during stress myocardial perfusion scintigraphy.

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial scintigraphy']

entities_list: @entity1669 :: ('MESH:D013967', 'Disease') :: ['autoimmune thyroid disease']

entities_list: @entity10979 :: ('MESH:D017256', 'Chemical') :: ['99mTc-sestamibi']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disease', 'thyroid diseases']

answer: @entity10979 :: (MESH:D017256,Chemical) :: ['99mTc-sestamibi']


abstract: BACKGROUND: In @entity438 , clotting can either stabilise the @entity439 sac via @entity439 , or it can have a detrimental effect by giving rise to @entity432 . OBJECTIVE: The work presented in this study details the development of an in silico model that combines, all the salient, clinically relevant features of @entity438 clotting. A comprehensive computational model of clotting that accounts for biochemical complexity coupled with three-dimensional haemodynamics in image-derived @entity1 @entity439 , and in the presence of virtually implanted interventional devices is presented. METHODS: The model is developed and presented in two stages. First, a two-dimensional computational model of clotting is presented, for an idealised geometry. This enables verification of the methods with existing, physiological data before the pathological state is considered. This model is used to compare the results predicted by two different underlying biochemical cascades. The two-dimensional model is then extended to image-derived, three-dimensional aneurysmal topologies by incorporating level set methods, demonstrating the potential use of this model. RESULTS AND CONCLUSION: As a proof of concept, comparisons are then made between treated and untreated @entity439 . The prediction of different clotting outcomes for different @entity1 demonstrates that with further development, refinement and validation, this methodology could be used for @entity1 -specific interventional planning. This article is protected by copyright. All rights reserved.

title: Computational modelling of clot development in @entity1 - specific XXXX cases.

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['embolic occlusion']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm', 'aneurysm occlusion']

entities_list: @entity438 :: ('MESH:D002532', 'Disease') :: ['cerebral aneurysms', 'cerebral aneurysm']

answer: @entity438 :: (MESH:D002532,Disease) :: ['cerebral aneurysm']


abstract: BACKGROUND: In @entity438 , clotting can either stabilise the @entity439 sac via @entity439 , or it can have a detrimental effect by giving rise to @entity432 . OBJECTIVE: The work presented in this study details the development of an in silico model that combines, all the salient, clinically relevant features of @entity438 clotting. A comprehensive computational model of clotting that accounts for biochemical complexity coupled with three-dimensional haemodynamics in image-derived @entity1 @entity439 , and in the presence of virtually implanted interventional devices is presented. METHODS: The model is developed and presented in two stages. First, a two-dimensional computational model of clotting is presented, for an idealised geometry. This enables verification of the methods with existing, physiological data before the pathological state is considered. This model is used to compare the results predicted by two different underlying biochemical cascades. The two-dimensional model is then extended to image-derived, three-dimensional aneurysmal topologies by incorporating level set methods, demonstrating the potential use of this model. RESULTS AND CONCLUSION: As a proof of concept, comparisons are then made between treated and untreated @entity439 . The prediction of different clotting outcomes for different @entity1 demonstrates that with further development, refinement and validation, this methodology could be used for @entity1 -specific interventional planning. This article is protected by copyright. All rights reserved.

title: Computational modelling of clot development in XXXX - specific @entity438 cases.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity1582 involves induction with @entity3600 , @entity786 , and @entity229 (BCP) and maintenance with either melphalan and @entity229 (MP), @entity229 , @entity632 , @entity500 , and @entity1891 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity137 in the @entity19 MOPC 104E @entity6872 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity5 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity137 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity137 . Most of the @entity19 on the PAIV regimen die due to @entity137 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity5 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity5 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity1582 maintenance regimen of @entity229 . XXXX , @entity500 , and @entity1891 in a @entity19 @entity6872 model.

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['Adriamycin']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'drug toxicity']

entities_list: @entity6872 :: ('MESH:D010954', 'Disease') :: ['plasmacytoma']

entities_list: @entity229 :: ('MESH:D011241', 'Chemical') :: ['prednisone']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity1891 :: ('MESH:D014750', 'Chemical') :: ['vincristine']

answer: @entity632 :: (MESH:D004317,Chemical) :: ['Adriamycin']


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity1582 involves induction with @entity3600 , @entity786 , and @entity229 (BCP) and maintenance with either melphalan and @entity229 (MP), @entity229 , @entity632 , @entity500 , and @entity1891 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity137 in the @entity19 MOPC 104E @entity6872 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity5 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity137 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity137 . Most of the @entity19 on the PAIV regimen die due to @entity137 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity5 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity5 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity1582 maintenance regimen of @entity229 . @entity632 , @entity500 , and XXXX in a @entity19 @entity6872 model.

answer: @entity1891 :: (MESH:D014750,Chemical) :: ['vincristine']


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity1582 involves induction with @entity3600 , @entity786 , and @entity229 (BCP) and maintenance with either melphalan and @entity229 (MP), @entity229 , @entity632 , @entity500 , and @entity1891 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity137 in the @entity19 MOPC 104E @entity6872 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity5 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity137 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity137 . Most of the @entity19 on the PAIV regimen die due to @entity137 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity5 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity5 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity1582 maintenance regimen of @entity229 . @entity632 , @entity500 , and @entity1891 in a @entity19 XXXX model.

answer: @entity6872 :: (MESH:D010954,Disease) :: ['plasmacytoma']


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity1582 involves induction with @entity3600 , @entity786 , and @entity229 (BCP) and maintenance with either melphalan and @entity229 (MP), @entity229 , @entity632 , @entity500 , and @entity1891 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity137 in the @entity19 MOPC 104E @entity6872 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity5 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity137 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity137 . Most of the @entity19 on the PAIV regimen die due to @entity137 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity5 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity5 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity1582 maintenance regimen of @entity229 . @entity632 , XXXX , and @entity1891 in a @entity19 @entity6872 model.

answer: @entity500 :: (MESH:D001379,Chemical) :: ['imuran']


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity1582 involves induction with @entity3600 , @entity786 , and @entity229 (BCP) and maintenance with either melphalan and @entity229 (MP), @entity229 , @entity632 , @entity500 , and @entity1891 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity137 in the @entity19 MOPC 104E @entity6872 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity5 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity137 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity137 . Most of the @entity19 on the PAIV regimen die due to @entity137 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity5 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity5 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of XXXX maintenance regimen of @entity229 . @entity632 , @entity500 , and @entity1891 in a @entity19 @entity6872 model.

answer: @entity1582 :: (MESH:D009101,Disease) :: ['myeloma']


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity1582 involves induction with @entity3600 , @entity786 , and @entity229 (BCP) and maintenance with either melphalan and @entity229 (MP), @entity229 , @entity632 , @entity500 , and @entity1891 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity137 in the @entity19 MOPC 104E @entity6872 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity5 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity137 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity137 . Most of the @entity19 on the PAIV regimen die due to @entity137 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity5 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity5 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity1582 maintenance regimen of XXXX . @entity632 , @entity500 , and @entity1891 in a @entity19 @entity6872 model.

answer: @entity229 :: (MESH:D011241,Chemical) :: ['prednisone']


abstract: A current southeastern cancer study group protocol for the treatment of multiple @entity1582 involves induction with @entity3600 , @entity786 , and @entity229 (BCP) and maintenance with either melphalan and @entity229 (MP), @entity229 , @entity632 , @entity500 , and @entity1891 (PAIV), or delayed treatment of relapsed cases following induction. These combinations of drugs are used as induction regimens to establish their chemotherapeutic effects and hematological @entity137 in the @entity19 MOPC 104E @entity6872 model. The three combinations of drugs produce rapid, reliable, and reproducible @entity5 regressions. However, MP is the only combination which consistently gives long-term disease-free survivors. This particular regimen has least @entity137 and is considered to be most effective. BCP produces complete remission with no relapses; however, long-term survivors are not observed with this combination due to early deaths because of @entity137 . Most of the @entity19 on the PAIV regimen die due to @entity137 . This combination is considered least effective. With the different drug regimens, toxic events and regressions are noted to occur at different time periods, indicating that perhaps @entity5 cells in different stages are being destroyed. Toxic events as measured by hematocrit and body weight changes always precede regression by several days. This disparity between rapid drug effects on the host and a delayed effect on the @entity5 remains unexplained but may possibly be used to advantage in designing future trials.

title: Assessment of @entity1582 maintenance regimen of @entity229 . @entity632 , @entity500 , and @entity1891 in a XXXX @entity6872 model.

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: UNASSIGNED: Yolk sac @entity5 are testicular germ-cell @entity5 of the non-seminoma type. In @entity291 , this @entity5 is very rare and to date has only been described three times. In @entity1 males, it usually occurs in @entity1 and @entity1 . Immunohistochemistry provides solid criteria for diagnostics. Especially present pathognomonic Schiller-Duval bodies are helpful for identification. In this report, a 32-day-old Holstein Friesian @entity291 presented with a highly enlarged right testis. Sonographic examination was performed and blood samples were taken to measure @entity251 and @entity172 levels. Furthermore, the testis was surgically removed and macroscopically, histologically, and immunohistochemically examined which lead to the diagnosis of @entity2970 . The second testis was descended until the age of nine months and histology revealed impaired spermatogenesis. This report provides the first sonographic images of @entity291 @entity2970 as well as the first information about hormone levels in @entity291 with this @entity5 . It also shows the importance to combine anamnesis, histomorphological, and immunohistochemical findings in order to diagnose yolk sac @entity5 when pathognomonic structures are not present.

title: XXXX and impaired spermatogenesis in a Holstein Friesian @entity291 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human', 'infants']

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'neoplasm']

entities_list: @entity2970 :: ('MESH:D018240', 'Disease') :: ['testicular yolk sac tumor']

entities_list: @entity291 :: ('9913', 'Species') :: ['calf', 'cattle', 'bovine', 'calves']

answer: @entity2970 :: (MESH:D018240,Disease) :: ['Testicular yolk sac tumor']


abstract: UNASSIGNED: Yolk sac @entity5 are testicular germ-cell @entity5 of the non-seminoma type. In @entity291 , this @entity5 is very rare and to date has only been described three times. In @entity1 males, it usually occurs in @entity1 and @entity1 . Immunohistochemistry provides solid criteria for diagnostics. Especially present pathognomonic Schiller-Duval bodies are helpful for identification. In this report, a 32-day-old Holstein Friesian @entity291 presented with a highly enlarged right testis. Sonographic examination was performed and blood samples were taken to measure @entity251 and @entity172 levels. Furthermore, the testis was surgically removed and macroscopically, histologically, and immunohistochemically examined which lead to the diagnosis of @entity2970 . The second testis was descended until the age of nine months and histology revealed impaired spermatogenesis. This report provides the first sonographic images of @entity291 @entity2970 as well as the first information about hormone levels in @entity291 with this @entity5 . It also shows the importance to combine anamnesis, histomorphological, and immunohistochemical findings in order to diagnose yolk sac @entity5 when pathognomonic structures are not present.

title: @entity2970 and impaired spermatogenesis in a Holstein Friesian XXXX .

answer: @entity291 :: (9913,Species) :: ['calf']


abstract: UNASSIGNED: The overarching goals of treatments for orthopedic conditions are generally to improve or restore function and alleviate @entity158 . Results of clinical trials are generally used to determine whether a treatment is efficacious; however, a statistically significant improvement may not actually be @entity922 , i.e., meaningful to the @entity1 . To determine whether an intervention has produced @entity922 benefits requires a two-step process: first, determining the magnitude of change considered @entity922 for a particular measure in the relevant population and, second, applying this yardstick to a @entity1 's data to determine whether s/he has benefited from treatment. Several metrics have been devised to quantify @entity922 differences, including the @entity922 ( @entity922 ) and @entity922 ( @entity922 ). Herein, we review the methods to generate the @entity922 and other metrics and their use and interpretation in clinical trials and practice. We particularly highlight the many pitfalls associated with the generation and utilization of these metrics that can impair their correct use. These pitfalls include the fact that different @entity158 measures yield different MCIDs, that efficacy in clinical trials is impacted by various factors (population characteristics, trial design), that the @entity922 value is impacted by the method used to calculate it (anchor, distribution), by the type of anchor chosen and by the definition (threshold) of improvement. The @entity922 is also dependent on the population characteristics such as disease type and severity, sex, age, etc. For appropriate use, the @entity922 should be applied to changes in individual subjects, not to group changes. The @entity922 and @entity922 are useful tools to define general guidelines to determine whether a treatment produces clinically meaningful effects. However, the many pitfalls associated with these metrics require a detailed understanding of the methods to calculate them and their context of use. Orthopedic surgeons that will use these metrics need to carefully understand them and be aware of their pitfalls.

title: Determining the clinical importance of treatment benefits for interventions for XXXX .

entities_list: @entity922 :: ('MESH:D013568', 'Disease') :: ['clinically important difference', 'clinically important', 'minimum clinically important difference', 'CID', 'MCID']

answer: @entity158 :: (MESH:D010146,Disease) :: ['painful orthopedic conditions']


abstract: BACKGROUND: Severe @entity5477 has limited therapeutic options. OBJECTIVES: To evaluate photodynamic therapy (PDT) using topical @entity19297 ( @entity7671 , 80 mg/g) as the photosensitiser in severe facial acne METHODS: Double-blind, randomised, vehicle-controlled multicentre trial in 153 @entity1 (12-35 years) with severe facial acne (Investigator Global Assessment [IGA] score 4; 25-75 inflammatory lesions with  <=3 nodules; 20-100 non-inflammatory lesions). Treatment (4 treatments 2 weeks apart) involved incubation with @entity7671 (n=100) or vehicle cream (n=53) 1.5 hours under @entity432 , then illumination (635 nm red light, total dose 37 J/cm(2) ). IGA assessment and standardised lesion counts were performed before each treatment and 12 weeks after first treatment. Treatment success was defined as improvement from baseline in IGA by >= 2 grades at 12 weeks. Safety assessments were @entity158 (10 cm visual analogue scale [VAS], immediately after illumination), erythema (four-point rating scale) and adverse events. RESULTS: At 12 weeks, PDT using 80 mg/g @entity7671 reduced inflammatory lesions versus vehicle PDT (mean change -15.6 vs. -7.8, p=0.006; mean percent change -37.3% vs. -16.2%, p=0.003). Although non-inflammatory lesions did not decrease significantly (mean change -11.8 vs. -10.7, p=0.85; mean percent change -28.6% vs. -24.9%, p=0.72). Treatment success rates were greater with 80 mg/g @entity7671 PDT (44% vs. 26%, p=0.013). @entity158 was low and manageable by briefly pausing illumination. There was similar @entity158 or erythema with successive treatments. CONCLUSIONS: PDT using topical 80 mg/g @entity7671 and red light may offer promise for severe @entity5477 . [ClinicalTrials. gov Identifier NCT01347879; registered May 3, 2011]. This article is protected by copyright. All rights reserved.

title: Photodynamic therapy with 80 mg/g XXXX for severe @entity5477 : a randomised vehicle-controlled study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5477 :: ('MESH:D000152', 'Disease') :: ['acne vulgaris']

entities_list: @entity19297 :: ('MESH:C475457', 'Chemical') :: ['methyl aminolaevulinate']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['occlusion']

answer: @entity19297 :: (MESH:C475457,Chemical) :: ['methyl aminolaevulinate']


abstract: BACKGROUND: Severe @entity5477 has limited therapeutic options. OBJECTIVES: To evaluate photodynamic therapy (PDT) using topical @entity19297 ( @entity7671 , 80 mg/g) as the photosensitiser in severe facial acne METHODS: Double-blind, randomised, vehicle-controlled multicentre trial in 153 @entity1 (12-35 years) with severe facial acne (Investigator Global Assessment [IGA] score 4; 25-75 inflammatory lesions with  <=3 nodules; 20-100 non-inflammatory lesions). Treatment (4 treatments 2 weeks apart) involved incubation with @entity7671 (n=100) or vehicle cream (n=53) 1.5 hours under @entity432 , then illumination (635 nm red light, total dose 37 J/cm(2) ). IGA assessment and standardised lesion counts were performed before each treatment and 12 weeks after first treatment. Treatment success was defined as improvement from baseline in IGA by >= 2 grades at 12 weeks. Safety assessments were @entity158 (10 cm visual analogue scale [VAS], immediately after illumination), erythema (four-point rating scale) and adverse events. RESULTS: At 12 weeks, PDT using 80 mg/g @entity7671 reduced inflammatory lesions versus vehicle PDT (mean change -15.6 vs. -7.8, p=0.006; mean percent change -37.3% vs. -16.2%, p=0.003). Although non-inflammatory lesions did not decrease significantly (mean change -11.8 vs. -10.7, p=0.85; mean percent change -28.6% vs. -24.9%, p=0.72). Treatment success rates were greater with 80 mg/g @entity7671 PDT (44% vs. 26%, p=0.013). @entity158 was low and manageable by briefly pausing illumination. There was similar @entity158 or erythema with successive treatments. CONCLUSIONS: PDT using topical 80 mg/g @entity7671 and red light may offer promise for severe @entity5477 . [ClinicalTrials. gov Identifier NCT01347879; registered May 3, 2011]. This article is protected by copyright. All rights reserved.

title: Photodynamic therapy with 80 mg/g @entity19297 for severe XXXX : a randomised vehicle-controlled study.

answer: @entity5477 :: (MESH:D000152,Disease) :: ['facial acne vulgaris']


abstract: OBJECTIVE: We examined the prospective influence of the resilient, undercontrolled, and overcontrolled personality prototypes on @entity308 and @entity1005 ( @entity1005 ) symptoms among Iraq/Afghanistan war veterans. After accounting for the possible influence of combat exposure, we expected that the resilient prototype would predict lower @entity308 and @entity1005 over time and would be associated with adaptive coping strategies, higher social support, lower @entity458 , and higher self-reported resilience relative to overcontrolled and undercontrolled prototypes, independent of @entity131 ( @entity131 ) status. METHOD: One hundred twenty-seven veterans (107 @entity1 , 20 @entity1 ; average age = 37) participated in the study. Personality was assessed at baseline, and @entity1005 and @entity308 symptoms were assessed 8 months later. Path analysis was used to test the direct and indirect effects of personality on distress. RESULTS: No direct effects were observed from personality to distress. The resilient prototype did have significant indirect effects on @entity1005 and @entity308 through its beneficial effects on social support, coping and @entity458 . @entity131 also had direct effects on @entity1005 . CONCLUSIONS: A resilient personality prototype appears to influence veteran adjustment through its positive associations with greater social support and @entity458 , and lower use of avoidant coping. Low social support, avoidant coping, and @entity458 are related to overcontrolled and undercontrolled personality prototypes, and these behaviors seem to characterize veterans who experience problems with @entity308 and @entity1005 over time. A positive @entity131 status is directly and prospectively associated with @entity1005 symptomology independent of personality prototype. Implications for clinical interventions and future research are discussed.

title: Resilience, XXXX , @entity308 , and posttraumatic stress among Iraq/Afghanistan war veterans.

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['TBI', 'traumatic brain injury']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological inflexibility', 'psychological flexibility']

entities_list: @entity1005 :: ('MESH:D013313', 'Disease') :: ['posttraumatic stress disorder', 'PTSD']

answer: @entity131 :: (MESH:D001930,Disease) :: ['traumatic brain injury']


abstract: OBJECTIVE: We examined the prospective influence of the resilient, undercontrolled, and overcontrolled personality prototypes on @entity308 and @entity1005 ( @entity1005 ) symptoms among Iraq/Afghanistan war veterans. After accounting for the possible influence of combat exposure, we expected that the resilient prototype would predict lower @entity308 and @entity1005 over time and would be associated with adaptive coping strategies, higher social support, lower @entity458 , and higher self-reported resilience relative to overcontrolled and undercontrolled prototypes, independent of @entity131 ( @entity131 ) status. METHOD: One hundred twenty-seven veterans (107 @entity1 , 20 @entity1 ; average age = 37) participated in the study. Personality was assessed at baseline, and @entity1005 and @entity308 symptoms were assessed 8 months later. Path analysis was used to test the direct and indirect effects of personality on distress. RESULTS: No direct effects were observed from personality to distress. The resilient prototype did have significant indirect effects on @entity1005 and @entity308 through its beneficial effects on social support, coping and @entity458 . @entity131 also had direct effects on @entity1005 . CONCLUSIONS: A resilient personality prototype appears to influence veteran adjustment through its positive associations with greater social support and @entity458 , and lower use of avoidant coping. Low social support, avoidant coping, and @entity458 are related to overcontrolled and undercontrolled personality prototypes, and these behaviors seem to characterize veterans who experience problems with @entity308 and @entity1005 over time. A positive @entity131 status is directly and prospectively associated with @entity1005 symptomology independent of personality prototype. Implications for clinical interventions and future research are discussed.

title: Resilience, @entity131 , XXXX , and posttraumatic stress among Iraq/Afghanistan war veterans.

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: UNASSIGNED: Each @entity0 has its unique spatial shape, but the clinical importance and the underlying mechanism for the three-dimensional @entity5 shapes are mostly unknown. We collected the data on the three-dimensional @entity5 size and @entity5 volume data of invasive @entity0 from 2,250 @entity1 who underwent surgery between Jan 2000 and Jul 2007. The degree of @entity5 eccentricity was estimated by using the difference between the spheroid @entity5 volume and ellipsoid @entity5 volume (spheroid-ellipsoid discrepancy, @entity11736 ). In 41 @entity1 , transcriptome and exome sequencing data obtained. Estimation of more accurate @entity5 burden by calculating ellipsoid @entity5 volumes did not improve the outcome prediction when compared to the traditional longest diameter measurement. However, the @entity5 eccentricity, which was measured by @entity11736 , showed significant variation between the molecular subtypes of @entity0 . Additionally, the degree of @entity5 eccentricity was associated with well-known prognostic factors of @entity0 such as @entity5 size and lymph node @entity3 . Transcriptome data from 41 @entity1 showed significant association between @entity1550 and @entity5 shapes. Network analysis and analysis of TCGA gene expression data suggest that @entity1550 is regulated by @entity1722 and @entity71488 . The present study validates the usefulness of the current @entity5 size method in determining @entity5 stages. Furthermore, we show that the @entity5 with high eccentricity are more likely to have aggressive @entity5 characteristics. Genes involved in the extracellular matrix remodeling can be candidate regulators of the @entity5 shapes in @entity0 .

title: The Clinical Significance and Molecular Features of the Spatial Tumor Shapes in XXXX .

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'spatial tumor', 'tumors']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity0 :: (MESH:D001943,Disease) :: ['Breast Cancers']


abstract: Most adults with @entity3458 ( @entity3458 ) receive care for their acute @entity158 episodes in an @entity341 ( @entity341 ) setting. The purpose of this article is to describe the impact of opening a dedicated treatment center for adults with @entity3458 [ @entity3458 ( @entity3458 )] on @entity1 outcomes and on hospital discharges for @entity3458 . Descriptive data including demographics, time to first dose of narcotic, and @entity158 scores were collected on @entity1 presenting to the @entity3458 and @entity341 . Maryland hospital discharge data were obtained from the Maryland Health Services Cost Review Commission. Analyses were conducted using T tests,   (2) tests, and simple generalized estimating equation regression models accounting for the clustered nature of observations, as appropriate. There were 3,874 visits to the @entity3458 by 361 unique @entity1 ; 85% of those visits resulted in the @entity1 being sent home. During the same time period, there were 3,408 visits to the @entity341 by 558 unique @entity1 with @entity3458 . The overall admission rate from the @entity341 for these @entity1 was 35.9% but decreased significantly over the time period with a rate of 20% in December 2011. There was a significant decrease in readmissions over time for the entire Baltimore Metro area with the likelihood of readmission decreasing by 7% over time. The @entity3458 model provides adults with @entity3458 access to high quality care that decreases the need for hospital admission. Further research needs to be done to evaluate the cost effectiveness of this model.

title: Impact of a dedicated infusion clinic for acute management of adults with sickle cell XXXX crisis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity341 :: ('MESH:D004630', 'Disease') :: ['emergency department', 'ED']

entities_list: @entity3458 :: ('MESH:D000755', 'Disease') :: ['SCD', 'SCIC', 'Sickle Cell Infusion Clinic', 'sickle cell disease']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'painful']

answer: @entity158 :: (MESH:D010146,Disease) :: ['pain']


abstract: UNASSIGNED: Background   The outcomes of @entity955 ( @entity955 ) between biatrial maze (BAM) and left atrial maze (LAM) are still controversial. The purpose of this study was to compare the clinical and rhythm outcomes between BAM and LAM in @entity1 with @entity955 . Methods   Electronic databases and article references were systematically searched (1990-2014) to access relevant studies. Odds ratio (OR) and @entity353 ( @entity353 ) with 95% confidence interval (CI) were reported. Results   Fourteen studies with 2,075 @entity1 were finally involved in the present meta-analysis. The rate of restored sinus rhythm (SR) was similar in BAM and LAM groups (OR: 1.25, 95% CI: 0.91-1.72, p   =   0.163). BAM reduced the prevalence of @entity956 during follow-up (OR: 0.12, 95% CI: 0.01-0.96, p   =   0.046). Compared with BAM, LAM shorten aortic cross-clamping time ( @entity353   =   9.05 minutes, 95% CI: 1.28-16.82, p   =   0.023) and cardiopulmonary bypass time ( @entity353   =   20.21 minutes, 95% CI: 7.40-33.03, p   =   0.002). No significant difference was found between groups in the risk of @entity204 (OR: 1.22, 95% CI: 0.70-2.14, p   =   0.233), cerebrovascular events (OR: 1.44, 95% CI: 0.51-4.06, p   =   0.493), and reoperation for @entity548 (OR: 1.34, 95% CI: 0.70-2.55, p   =   0.374). However, the risk for implantation of permanent pacemaker was significantly higher in BAM group (OR: 2.60, 95% CI: 1.09-6.20, p   =   0.031). Conclusion   No significant difference was found between BAM and LAM in the rate of restored SR, the risk of @entity204 , cerebrovascular events, and reoperation for @entity548 . BAM is superior to LAM in reducing the prevalence of @entity956 during follow-up, but LAM shortens the aortic cross-clamping time and cardiopulmonary bypass time, and decreases the risk of permanent pacemaker implantation.

title: Comparison of Left Atrial and Biatrial Maze Procedure in the Treatment of XXXX : A Meta-Analysis of Clinical Studies.

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['WMD', 'weight mean difference']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity956 :: ('MESH:D001282', 'Disease') :: ['atrial flutter']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

answer: @entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']


abstract: OBJECTIVE: To summarize the effect of antipsychotics for preventing @entity260 . DESIGN: We conducted a literature search using Medline, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and clinicaltrials.gov. We included randomized controlled trials of adults undergoing surgery who were given antipsychotics to prevent @entity260 . Quality was assessed via the Cochrane risk of bias tool. Random-effects meta-analysis and meta-regression were conducted. Q-statistics and I(2) were used for assessment of heterogeneity. The main outcome was @entity933 incidence using validated definitions. RESULTS: A total of 1710 subjects were included, with a mean age ranging from 60.7 to 86.4   years. Antipsychotics reduced the incidence of @entity260 with the global effect-size estimate (weighted odds ratio) using the random effects model of 0.44 (95% confidence interval: 0.28-0.70; N   =   6; Q-value: 16, p-value 0.0005; I(2)    =   69%). Significant heterogeneity existed with the pooled global effect of @entity933 incidence; however, meta-regression allowed us to test both treatment-level and @entity1 -level explanations for significant between-study variance. Baseline risk for @entity933 was found to be a significant contributor to study heterogeneity, and meta-regression suggested that antipsychotic type and dosage were two of the several treatment-level factors that also may have led to heterogeneity. Our analysis implied the presence of a breakeven baseline level of @entity933 risk below which preventive treatment with antipsychotics might prove ineffective. CONCLUSIONS: Within the limits of few randomized controlled trials, antipsychotics appeared to reduce the incidence of @entity260 in several surgical settings, predominantly orthopedic and for those at higher risk for @entity933 . Copyright    2015 John Wiley _ Sons, Ltd.

title: Do antipsychotics prevent XXXX ? A systematic review and meta-analysis.

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative delirium']

answer: @entity260 :: (MESH:D011183,Disease) :: ['postoperative delirium']


abstract: BACKGROUND: One of the most important functions of the @entity341 ( @entity341 ) is to assess @entity1 status. Only one, the pediatric early warning score (PEWS), has been designed for @entity341 with acceptable validity, but it has never been validated in Thailand. The objective of this study was to validate PEWS in predicting hospitalization in @entity1 visiting the @entity341 . METHODS: During the initial phase, two triage nurses performed blind scoring (in order to determine inter-rater reliability using kappa statistics) for the first 30 @entity1 who presented to the @entity341 at Ramathibodi Hospital between March and May 2014 and who were aged <15   years. The second phase then consisted of validation and involved 1136 @entity1 . @entity1 who presented with @entity130 , @entity146 , dental and surgical concerns were excluded. Validity of the scoring system in predicting admission was assessed using area under the receiver operating characteristics (ROC) curve (AUC), sensitivity, and specificity, positive predictive value ( @entity2286 ) and negative predictive value (NPV). RESULTS: Phase I demonstrated good inter-rater reliability (kappa = 0.75). In phase II, of the total group of 1136 @entity1 , 168 @entity1 (14.8%) were admitted: 162 to the general ward and six to the intensive care unit (ICU) during the study period. AUC for predicting overall, ICU, and general ward admission were 0.73 (95%CI: 0.68-0.77), 0.98 (95%CI: 0.96-1) and 0.71 (95%CI: 0.66-0.75), respectively. The sensitivity and specificity in predicting overall admission with a cut-off of PEWS >= 1 was 78% and 60%, respectively ( @entity2286 , 28%; NPV, 95%). Sensitivity and specificity in predicting ICU admission with the cut-off PEWS >= 3 was 100% and 91%, respectively ( @entity2286 , 5%; NPV, 100%). Using the cut-off PEWS >= 1, sensitivity and specificity in predicting ward admission were 77% and 59%, respectively ( @entity2286 , 24%; NPV, 94%). CONCLUSION: PEWS can be helpful in assessing @entity1 status in pediatric @entity341 with acceptable validity and can serve as a potentially excellent screening tool for prediction of ICU admission.

title: Validation of pediatric early warning score in pediatric XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity341 :: (MESH:D004630,Disease) :: ['emergency department']


abstract: UNASSIGNED: Irradiation in conjunction with gene therapy is considered for efficient @entity5 treatment. Mesenchymal stem cells (MSCs), due to their irradiation-promotable @entity5 tropism, are ideal delivery vehicles for gene therapy. In this study, we investigated whether treatment with radiation and interleukin (IL)-12-expressing MSCs (MSCs/IL-12) exerts improved antitumor effects on @entity19 metastatic @entity157 . HCa-I and Hepa 1-6 cells were utilized to generate heterotopic @entity19 @entity157 models. Tumor-bearing @entity19 were treated with irradiation or MSCs/IL-12 alone, or a combination. @entity1750 ( @entity1750 / @entity1750 ) expression was assessed in irradiated @entity157 tissues to confirm a chemotactic effect. Combination treatment strategies were established and their therapeutic efficacies were evaluated by monitoring @entity5 growth, @entity3 and survival rate. IL-12 expression was assessed and the apoptotic activity and immunological alterations in the @entity5 microenvironment were examined. @entity1750 / @entity1750 expression and localization of MSCs/IL-12 increased in the irradiated @entity19 @entity157 cells. The antitumor effects, including suppression of pulmonary @entity3 and survival rate improvements, were increased by the combination treatment with irradiation and MSCs/IL-12. IL-12 expression was increased in @entity5 cells, causing proliferation of cluster of differentiation 8(+) T-lymphocytes and natural killer cells. The apoptotic activity increased, indicating that the @entity137 of immune cells was involved in the antitumor effect of the combined treatment. Treatment with irradiation and MSCs/IL-12 showed effectiveness in treating @entity19 metastatic @entity157 . IL-12-induced proliferation of immune cells played an important role in apoptosis of @entity5 cells. Our results suggest that treatment with irradiation and MSCs/IL-12 may be a useful strategy for enhancing antitumor activity in metastatic @entity157 .

title: Irradiation-induced localization of IL-12-expressing mesenchymal stem cells to enhance the curative effect in @entity19 metastatic XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['cytotoxicity']

entities_list: @entity1750 :: ('20296(Tax:10090)', 'Gene') :: ['Monocyte chemoattractant protein-1', 'CCL2', 'MCP-1']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatoma']

answer: @entity157 :: (MESH:D006528,Disease) :: ['hepatoma']


abstract: UNASSIGNED: Irradiation in conjunction with gene therapy is considered for efficient @entity5 treatment. Mesenchymal stem cells (MSCs), due to their irradiation-promotable @entity5 tropism, are ideal delivery vehicles for gene therapy. In this study, we investigated whether treatment with radiation and interleukin (IL)-12-expressing MSCs (MSCs/IL-12) exerts improved antitumor effects on @entity19 metastatic @entity157 . HCa-I and Hepa 1-6 cells were utilized to generate heterotopic @entity19 @entity157 models. Tumor-bearing @entity19 were treated with irradiation or MSCs/IL-12 alone, or a combination. @entity1750 ( @entity1750 / @entity1750 ) expression was assessed in irradiated @entity157 tissues to confirm a chemotactic effect. Combination treatment strategies were established and their therapeutic efficacies were evaluated by monitoring @entity5 growth, @entity3 and survival rate. IL-12 expression was assessed and the apoptotic activity and immunological alterations in the @entity5 microenvironment were examined. @entity1750 / @entity1750 expression and localization of MSCs/IL-12 increased in the irradiated @entity19 @entity157 cells. The antitumor effects, including suppression of pulmonary @entity3 and survival rate improvements, were increased by the combination treatment with irradiation and MSCs/IL-12. IL-12 expression was increased in @entity5 cells, causing proliferation of cluster of differentiation 8(+) T-lymphocytes and natural killer cells. The apoptotic activity increased, indicating that the @entity137 of immune cells was involved in the antitumor effect of the combined treatment. Treatment with irradiation and MSCs/IL-12 showed effectiveness in treating @entity19 metastatic @entity157 . IL-12-induced proliferation of immune cells played an important role in apoptosis of @entity5 cells. Our results suggest that treatment with irradiation and MSCs/IL-12 may be a useful strategy for enhancing antitumor activity in metastatic @entity157 .

title: Irradiation-induced localization of IL-12-expressing mesenchymal stem cells to enhance the curative effect in XXXX metastatic @entity157 .

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: OBJECTIVES: To investigate the efficacy and safety of percutaneous @entity384 (PTBD) for the treatment of bilateral pulmonary artery banding (bil-PAB) site @entity850 . Background: Although bil-PAB is an alternative initial treatment for high-risk neonates with @entity1699 ( @entity1699 ) or critical @entity472 (cAS), those @entity1 often suffer from desaturation because of progressive @entity850 of the bil-PAB sites during the interstage period. METHODS: We retrospectively evaluated the efficacy and safety of 11 consecutive PTBD procedures performed between 2006 and 2012 to treat bil-PAB site @entity850 in four high-risk @entity1 (three females) with @entity1699 or cAS. RESULTS: PTBD was repeated twice in two @entity1 and three times in one @entity1 over intervals. The mean @entity661 ( @entity661 ) and @entity661 -to-band circumference (BC) ratio were 3.1        0.5 mm and 0.31        0.06, respectively. After the procedures, the mean minimum lumen diameter was dilated significantly from 1.1        0.1 mm to 1.7        0.3 mm (P   <   0.01), and the mean peripheral @entity26 saturation increased significantly from 75        8% to 85        4% (P   <   0.01). All @entity1 reached the next stage operation involving the Norwood _ bidirectional Glenn or Ross procedure, after growth. No complications such as band @entity397 occurred. CONCLUSIONS: For progressive @entity850 of bil-PAB sites, PTBD using a balloon size that did not exceed the BC ( @entity661 around 30% of the BC) was an effective and safe procedure.    2015 Wiley Periodicals, Inc.

title: Efficacy and safety of percutaneous @entity384 to prevent progression of banding site XXXX after bilateral pulmonary artery banding.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'infants']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['transluminal balloon dilation']

entities_list: @entity1699 :: ('MESH:D018636', 'Disease') :: ['hypoplastic left heart syndrome', 'HLHS']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity472 :: ('MESH:D001024', 'Disease') :: ['aortic stenosis']

entities_list: @entity661 :: ('MESH:D054549', 'Disease') :: ['balloon diameter', 'BD']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity850 :: (MESH:D003251,Disease) :: ['stenosis']


abstract: OBJECTIVES: To investigate the efficacy and safety of percutaneous @entity384 (PTBD) for the treatment of bilateral pulmonary artery banding (bil-PAB) site @entity850 . Background: Although bil-PAB is an alternative initial treatment for high-risk neonates with @entity1699 ( @entity1699 ) or critical @entity472 (cAS), those @entity1 often suffer from desaturation because of progressive @entity850 of the bil-PAB sites during the interstage period. METHODS: We retrospectively evaluated the efficacy and safety of 11 consecutive PTBD procedures performed between 2006 and 2012 to treat bil-PAB site @entity850 in four high-risk @entity1 (three females) with @entity1699 or cAS. RESULTS: PTBD was repeated twice in two @entity1 and three times in one @entity1 over intervals. The mean @entity661 ( @entity661 ) and @entity661 -to-band circumference (BC) ratio were 3.1        0.5 mm and 0.31        0.06, respectively. After the procedures, the mean minimum lumen diameter was dilated significantly from 1.1        0.1 mm to 1.7        0.3 mm (P   <   0.01), and the mean peripheral @entity26 saturation increased significantly from 75        8% to 85        4% (P   <   0.01). All @entity1 reached the next stage operation involving the Norwood _ bidirectional Glenn or Ross procedure, after growth. No complications such as band @entity397 occurred. CONCLUSIONS: For progressive @entity850 of bil-PAB sites, PTBD using a balloon size that did not exceed the BC ( @entity661 around 30% of the BC) was an effective and safe procedure.    2015 Wiley Periodicals, Inc.

title: Efficacy and safety of percutaneous XXXX to prevent progression of banding site @entity850 after bilateral pulmonary artery banding.

answer: @entity384 :: (MESH:D002311,Disease) :: ['transluminal balloon dilation']