abstract: BACKGROUND _ AIMS: The aim of this study was to systematically assess the diagnostic and prognostic value of early liver biopsy in @entity1 who require hospital admission with @entity697 of @entity7160 . METHODS: Sixty-eight @entity1 with @entity697 of @entity7160 underwent a liver biopsy within 7 days and the biopsies were processed using routine stains and K8/18 immunohistochemistry to characterize @entity528 . The biopsies were scored by two independent histopathologists using pre-defined criteria. The @entity1 were managed according to institutional protocols and followed until the time of hospital discharge or @entity204 . RESULTS: With use of K8/18 immunohistochemistry, very high concordance rate for the diagnosis of @entity528 was reached (r = 0.7; p = 0.0001). The presence of a @entity1850 ( @entity1850 ) suggestive of @entity7936 ( @entity7936 ), predicts severe @entity7936 histologically in only 50% @entity1 . Moreover, in 41% of @entity1850 negative @entity1 who were thought not to have @entity7936 , a diagnosis of @entity7936 was subsequently confirmed on histological grading. @entity1 that have @entity1850 criteria but no evidence of histological @entity7936 are more likely to develop @entity281 which may be indicated by the severity of canalicular @entity1448 . Nineteen @entity1 died during follow up. @entity1 manifesting @entity7936 on biopsy who were also @entity1850 positive, had a significantly greater risk of mortality compared to those that were @entity1850 positive but @entity7936 negative (p < 0.01) and those that were @entity1850 negative (p < 0.0001). CONCLUSIONS: The use of K8/18 immunostaining allows grading of the severity of @entity7936 . Early liver biopsy in these @entity1 presenting with @entity697 of @entity82 is safe and provides important diagnostic and prognostic information.

title: The role of liver biopsy in the diagnosis and prognosis of @entity1 with XXXX of @entity7160 .

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute deterioration']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity7936 :: ('MESH:D005235', 'Disease') :: ['acute alcoholic steatohepatitis', 'alcoholic steatohepatitis', 'ASH']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity1448 :: ('MESH:D002779', 'Disease') :: ['cholestasis']

entities_list: @entity1850 :: ('MESH:D018746', 'Disease') :: ['SIRS', 'systemic inflammatory response']

entities_list: @entity7160 :: ('MESH:D008104', 'Disease') :: ['alcoholic cirrhosis']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['balloon degeneration']

answer: @entity697 :: (MESH:D000208,Disease) :: ['acute deterioration']


abstract: BACKGROUND _ AIMS: The aim of this study was to systematically assess the diagnostic and prognostic value of early liver biopsy in @entity1 who require hospital admission with @entity697 of @entity7160 . METHODS: Sixty-eight @entity1 with @entity697 of @entity7160 underwent a liver biopsy within 7 days and the biopsies were processed using routine stains and K8/18 immunohistochemistry to characterize @entity528 . The biopsies were scored by two independent histopathologists using pre-defined criteria. The @entity1 were managed according to institutional protocols and followed until the time of hospital discharge or @entity204 . RESULTS: With use of K8/18 immunohistochemistry, very high concordance rate for the diagnosis of @entity528 was reached (r = 0.7; p = 0.0001). The presence of a @entity1850 ( @entity1850 ) suggestive of @entity7936 ( @entity7936 ), predicts severe @entity7936 histologically in only 50% @entity1 . Moreover, in 41% of @entity1850 negative @entity1 who were thought not to have @entity7936 , a diagnosis of @entity7936 was subsequently confirmed on histological grading. @entity1 that have @entity1850 criteria but no evidence of histological @entity7936 are more likely to develop @entity281 which may be indicated by the severity of canalicular @entity1448 . Nineteen @entity1 died during follow up. @entity1 manifesting @entity7936 on biopsy who were also @entity1850 positive, had a significantly greater risk of mortality compared to those that were @entity1850 positive but @entity7936 negative (p < 0.01) and those that were @entity1850 negative (p < 0.0001). CONCLUSIONS: The use of K8/18 immunostaining allows grading of the severity of @entity7936 . Early liver biopsy in these @entity1 presenting with @entity697 of @entity82 is safe and provides important diagnostic and prognostic information.

title: The role of liver biopsy in the diagnosis and prognosis of @entity1 with @entity697 of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

answer: @entity7160 :: (MESH:D008104,Disease) :: ['alcoholic cirrhosis']


abstract: BACKGROUND _ AIMS: The aim of this study was to systematically assess the diagnostic and prognostic value of early liver biopsy in @entity1 who require hospital admission with @entity697 of @entity7160 . METHODS: Sixty-eight @entity1 with @entity697 of @entity7160 underwent a liver biopsy within 7 days and the biopsies were processed using routine stains and K8/18 immunohistochemistry to characterize @entity528 . The biopsies were scored by two independent histopathologists using pre-defined criteria. The @entity1 were managed according to institutional protocols and followed until the time of hospital discharge or @entity204 . RESULTS: With use of K8/18 immunohistochemistry, very high concordance rate for the diagnosis of @entity528 was reached (r = 0.7; p = 0.0001). The presence of a @entity1850 ( @entity1850 ) suggestive of @entity7936 ( @entity7936 ), predicts severe @entity7936 histologically in only 50% @entity1 . Moreover, in 41% of @entity1850 negative @entity1 who were thought not to have @entity7936 , a diagnosis of @entity7936 was subsequently confirmed on histological grading. @entity1 that have @entity1850 criteria but no evidence of histological @entity7936 are more likely to develop @entity281 which may be indicated by the severity of canalicular @entity1448 . Nineteen @entity1 died during follow up. @entity1 manifesting @entity7936 on biopsy who were also @entity1850 positive, had a significantly greater risk of mortality compared to those that were @entity1850 positive but @entity7936 negative (p < 0.01) and those that were @entity1850 negative (p < 0.0001). CONCLUSIONS: The use of K8/18 immunostaining allows grading of the severity of @entity7936 . Early liver biopsy in these @entity1 presenting with @entity697 of @entity82 is safe and provides important diagnostic and prognostic information.

title: The role of liver biopsy in the diagnosis and prognosis of XXXX with @entity697 of @entity7160 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Epistasis is a key factor in evolution since it determines which combinations of mutations provide adaptive solutions and which mutational pathways toward these solutions are accessible by natural selection. There is growing evidence for the pervasiveness of sign epistasis-a complete reversion of mutational effects, particularly in protein evolution-yet its molecular basis remains poorly understood. We describe the structural basis of sign epistasis between @entity48627 and @entity72974 , two adaptive mutations in @entity25054 b-lactamase- an enzyme that endows antibiotics resistance. Separated by 10  , these mutations initiate two separate trajectories toward increased hydrolysis rates and resistance toward second and third-generation cephalosporins antibiotics. Both mutations allow the enzyme's active site to adopt alternative conformations and accommodate the new antibiotics. By solving the corresponding set of crystal structures, we found that @entity72974 causes @entity74 whereas @entity48627 induces discrete conformations. When combined, the mutations in 238 and 164 induce @entity74 whereby nonproductive conformations that perturb the enzyme's catalytic preorganization dominate. Specifically, @entity2734 170 that coordinates the deacylating water molecule is misaligned, in both the free form and the inhibitor-bound double mutant. This @entity74 is not restored by stabilizing global suppressor mutations and thus leads to an evolutionary cul-de-sac. Conformational dynamism therefore underlines the reshaping potential of protein's structures and functions but also limits protein evolvability because of the fragility of the interactions networks that maintain protein structures.

title: Negative Epistasis and Evolvability in XXXX b-Lactamase-The Thin Line between an Enzyme's Conformational Freedom and Disorder.

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['local disorder']

answer: @entity25054 :: (57124,Gene) :: ['TEM-1']


abstract: BACKGROUND: Although many comprehensive batteries exist to evaluate the nature and degree of @entity73 in @entity1 with @entity161 , short batteries hold promise for rapidly screening and estimating @entity73 . Recently, the Brief Neurocognitive Assessment (BNA) was established and has been shown to have similar validity and utility to a more comprehensive battery of cognitive tests in evaluating global @entity73 in @entity1 with @entity161 . The present study sought to further establish the validity of the BNA by comparing it with the MATRICS Consensus Cognitive Battery (MCCB). METHODS: One-hundred seventy-six @entity1 with @entity161 and 300 healthy volunteers participated in the present study. Global cognition was evaluated using the MCCB composite score and estimated using the BNA. To examine practice effects and test-retest reliability, @entity1 were re-assessed after 4weeks. RESULTS: The BNA was highly correlated with global cognition as evaluated by the MCCB in both the @entity161 (r=0.82) and healthy control samples (r=0.75). Both instruments were similarly sensitive to @entity73 in @entity1 with @entity161 relative to healthy controls. The BNA also demonstrated high test-retest reliability in @entity1 with @entity161 (r=0.87), comparable to the level observed with the MCCB (r=0.91). In addition, both the BNA and MCCB showed a similar level of practice effects (both Cohen's d=0.11), and both instruments demonstrated equivalent sensitivities to longitudinal change. Furthermore, scores from the BNA and MCCB were related to symptom severity and functional capacity to a similar degree. CONCLUSIONS: The BNA provides clinicians and researchers with an efficient and reliable means by which to evaluate global @entity149 in @entity1 with @entity161 by allowing estimation of performance on a more comprehensive standardized battery.

title: Examination of the validity of the Brief Neurocognitive Assessment (BNA) for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitive impairments', 'deficits in global cognition']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['neurocognitive impairments']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: BACKGROUND: @entity5 is an important health problem, due to the increasing number of new cases and the quality of life issues brought forth by surgical treatment in these @entity1 . AIM: The aim of the study was to analyse the results of robotic surgery in the treatment of lower and middle @entity5 ,locations in which @entity348 is performed. MATERIAL AND METHOD: @entity1 diagnosed with and operated on for @entity5 by the means of robotic surgery between 2008-2012 at the Fundeni Clinical Institute were retrospectively analysed. RESULTS: A number of 117 @entity1 with @entity5 were operated on by robotic surgery, of which 79 (67.52%) were submitted to @entity348 ( @entity348 ). The most frequently performed surgery was low anterior resection, followed by rectal amputation through abdominoperineal approach. @entity254 @entity292 was observed in 9 (11.39%) @entity1 . Local recurrence was encountered in 2 (2.53%) of the robotically performed surgeries. CONCLUSIONS: 1. Robotically assisted @entity348 is feasible, safe and can be performed with a small number of complications and a low local recurrence rate; 2. The main advantages are oncological safety and quality of life; 3.Conversion to open surgery is rarely encountered; 4. Protection loop ileostomy existence allows avoiding reintervention in case anastomotic @entity292 occurs in @entity1 with low anterior resection. 5. Robotic surgery may become gold standard in the surgical treatment of @entity5 .

title: Robotically performed XXXX for @entity5 .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer', 'Rectal cancer']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['Anastomosis']

entities_list: @entity348 :: ('MESH:C535338', 'Disease') :: ['TME', 'total mesorectal excision']

answer: @entity348 :: (MESH:C535338,Disease) :: ['total mesorectal excision']


abstract: BACKGROUND: @entity5 is an important health problem, due to the increasing number of new cases and the quality of life issues brought forth by surgical treatment in these @entity1 . AIM: The aim of the study was to analyse the results of robotic surgery in the treatment of lower and middle @entity5 ,locations in which @entity348 is performed. MATERIAL AND METHOD: @entity1 diagnosed with and operated on for @entity5 by the means of robotic surgery between 2008-2012 at the Fundeni Clinical Institute were retrospectively analysed. RESULTS: A number of 117 @entity1 with @entity5 were operated on by robotic surgery, of which 79 (67.52%) were submitted to @entity348 ( @entity348 ). The most frequently performed surgery was low anterior resection, followed by rectal amputation through abdominoperineal approach. @entity254 @entity292 was observed in 9 (11.39%) @entity1 . Local recurrence was encountered in 2 (2.53%) of the robotically performed surgeries. CONCLUSIONS: 1. Robotically assisted @entity348 is feasible, safe and can be performed with a small number of complications and a low local recurrence rate; 2. The main advantages are oncological safety and quality of life; 3.Conversion to open surgery is rarely encountered; 4. Protection loop ileostomy existence allows avoiding reintervention in case anastomotic @entity292 occurs in @entity1 with low anterior resection. 5. Robotic surgery may become gold standard in the surgical treatment of @entity5 .

title: Robotically performed @entity348 for XXXX .

answer: @entity5 :: (MESH:D009369,Disease) :: ['rectal cancer']


abstract: INTRODUCTION: The laparoscopic-assisted abdominoperineal resection (LAPR) has been proved to be associated with a shorter postoperative recovery, with equivalent oncological results and similar survival when compared with conventional open surgery, for @entity1 with @entity5 . METHOD: Case report of a massive @entity954 during LAPR and systematic review of the English language literature, using PubMed Medline, ISI Thopmson, OVID and EMBASE databases. RESULTS: 58 years old @entity1 admitted in emergency setting or @entity548 . Rectal examination revealed a protruding,frail @entity5 , located 2 cm from the anal verge. Total colono scopy revealed an infiltrative, protruding @entity5 , situated at 2 cm from the anal verge, with a 5 cm cranial extension,without any additional @entity1049 . Computed Tomography showed a 4,5 cm circumferential rectal wall thickening, without any enlarged mesorectal or abdominal lymph nodes. The @entity1 was transported to operating room for a LAPR. During final hemostasis, at the level of perineal surgical wound, an acute massive @entity548 occurred from the presacral vessels with severe @entity190 . This @entity548 couldnot be managed laparo scopicaly and conversion to laparotomywas decided, with pelvic packing. At 48 hours after the initial surgical approach, the tamponing packs were removed, without signs of active @entity548 . There were applied haemostatic agents and the perineal wound was sutured, without further rbleeding during in-hospital stay. CONCLUSIONS: A rapid and effective control of the @entity548 is mandatory to prevent a fatal outcome. Pelvic packing remains a life-saving procedure and the treatment of choice in severe cases.

title: Massive XXXX after laparoscopic assisted abdominoperineal resection: a case report and systematic review of the literature.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['rectal bleeding', 'presacral bleeding', 'bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'low rectal cancer']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['intraoperative bleeding']

entities_list: @entity1049 :: ('MESH:D003108', 'Disease') :: ['colonic lesions']

answer: @entity954 :: (MESH:D016063,Disease) :: ['intraoperative bleeding']


abstract: AIM: The potential psycho-social sequelae of traumatic @entity8494 have received increasing attention in recent years, however there remains paucity of cross-national comparative data on the prevalence of @entity458 following such @entity130 . The aim of the present study was to investigate and compare the prevalence of @entity148 and @entity308 in an adult @entity1 group who have been treated for maxillofacial @entity130 , and who attend a follow-up clinic in either the West Midlands, UK or New South Wales (NSW), Australia. By using an identical methodological and statistical approach, we hoped to add to the available information on the incidence of early @entity458 in @entity1 following facial @entity130 . METHOD: This was a comparative cross-sectional study. A sample of fifty consecutive adult victims of facial @entity130 in the West Midlands UK, was compared to a group of fifty-two facially injured @entity1 in NSW, Australia. Demographic data was collected, following which the @entity308 and @entity148 Scale (HADS) were applied to both groups of @entity1 . RESULTS: Psychometric scores suggestive of @entity148 and @entity308 state were common in both groups of @entity1 . The mean HADS @entity308 subscale score for UK @entity1 compared to Australian @entity1 was not significantly different (5.94 versus 5.54 p=0.62). This was also the case for the HADS @entity148 subscale (5.96 versus 5.94 p=0.98). Although the number of @entity1 achieving scores suggestive of a 'caseness' for co-morbid psychological state was higher within the UK sample when compared to the Australian group (20% versus 11.5% for HADS @entity308 subscale, and 20% versus 15% for HADS @entity148 subscales respectively); these differences did not reach statistical significance. CONCLUSION: This cross-national comparative study has shown that @entity148 and @entity308 in @entity2123 were comparable in both settings.

title: The prevalence of XXXX in a sample of @entity2123 . A comparative cross-sectional study between UK and Australia.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Hospital Depression', 'depression', 'depressive']

entities_list: @entity2123 :: ('MESH:D020220', 'Disease') :: ['facial trauma victims']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['Anxiety', 'anxiety']

entities_list: @entity8494 :: ('MESH:D005151', 'Disease') :: ['facial injury']

answer: @entity458 :: (MESH:D020018,Disease) :: ['psychological distress']


abstract: AIM: The potential psycho-social sequelae of traumatic @entity8494 have received increasing attention in recent years, however there remains paucity of cross-national comparative data on the prevalence of @entity458 following such @entity130 . The aim of the present study was to investigate and compare the prevalence of @entity148 and @entity308 in an adult @entity1 group who have been treated for maxillofacial @entity130 , and who attend a follow-up clinic in either the West Midlands, UK or New South Wales (NSW), Australia. By using an identical methodological and statistical approach, we hoped to add to the available information on the incidence of early @entity458 in @entity1 following facial @entity130 . METHOD: This was a comparative cross-sectional study. A sample of fifty consecutive adult victims of facial @entity130 in the West Midlands UK, was compared to a group of fifty-two facially injured @entity1 in NSW, Australia. Demographic data was collected, following which the @entity308 and @entity148 Scale (HADS) were applied to both groups of @entity1 . RESULTS: Psychometric scores suggestive of @entity148 and @entity308 state were common in both groups of @entity1 . The mean HADS @entity308 subscale score for UK @entity1 compared to Australian @entity1 was not significantly different (5.94 versus 5.54 p=0.62). This was also the case for the HADS @entity148 subscale (5.96 versus 5.94 p=0.98). Although the number of @entity1 achieving scores suggestive of a 'caseness' for co-morbid psychological state was higher within the UK sample when compared to the Australian group (20% versus 11.5% for HADS @entity308 subscale, and 20% versus 15% for HADS @entity148 subscales respectively); these differences did not reach statistical significance. CONCLUSION: This cross-national comparative study has shown that @entity148 and @entity308 in @entity2123 were comparable in both settings.

title: The prevalence of @entity458 in a sample of XXXX . A comparative cross-sectional study between UK and Australia.

answer: @entity2123 :: (MESH:D020220,Disease) :: ['facial trauma victims']


abstract: @entity302 surgery plays a pivotal role in the successful treatments of @entity302 . In China, economic burden for @entity302 @entity1 is heavy. Because of limited economic resources, appropriate utilization of presurgical evaluation technologies is especially important for @entity258 @entity1 , who could benefit from surgery. This study proposed the strategies for restricting the cost of presurgical evaluation for resective surgery in @entity258 population with @entity302 . A retrospective study was performed on the database of @entity1 with resective surgery from January 2007 to June 2009 in West China Hospital of Sichuan University. Presurgical evaluation technologies and outcome were analyzed. As a result, 143 @entity1 underwent resective operation were included in this study. @entity410 free can be reached at 63.8% @entity1 with (ATL) and 61.1% with focal lesionectomy (FLE). Magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), positron emission tomography (PET), routine electroencephalography (REEG), video-EEG (VEEG) and invasive-EEG (IEEG) were used for investigation. The cost of those technologies was listed for consultation. Based on these findings, how to make the proper choice for surgery candidates was suggested according to different types of @entity302 .

title: How to effectively constrain the cost of presurgical evaluation for resective surgery in XXXX population: clinically oriented opinions.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['low-income']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['refractory epilepsy', 'epileptic', 'epilepsy', 'intractable epilepsy', 'Epilepsy']

answer: @entity258 :: (MESH:D009800,Disease) :: ['low-income']


abstract: The @entity238 middle midgut cells derived from the endoderm develop into four distinct types of cell. Of these cells, @entity920 cells have invaginated microvillar membranes on their apical surface, and they are involved in two distinct functions, i.e., @entity920 absorption and acid secretion. The homeobox gene @entity72975 proventriculus (dve) is expressed in the midgut, and two transcripts, type A (   4.9kb) and type B (   3.5kb), have been identified. We isolated the deletion allele dve(E181) that completely removes the first exon for type-A (dve-A) transcript. Dve expression pattern in dve-A mutant background indicates that isoform switching is dynamically regulated in a cell-type specific manner. Using RNAi for dve-A, we examined spatial and temporal requirement of the Dve-A activity. Early Dve-A activity is required to repress isoform switching in @entity920 cells, and for establishment of two gut functions. Late Dve-A activity in @entity920 cells, but not in adjacent interstitial cells, is required for acid secretion, while the activity is redundantly required in both cells for the @entity920 absorptive function. Furthermore, ectopic type-B expression in larval @entity920 cells specifically impaired the @entity920 absorptive function. These results provide insight into molecular mechanisms to establish functional specificity.

title: Spatial and temporal requirement of @entity72975 proventriculus activity during XXXX midgut development.

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

answer: @entity238 :: (7227,Species) :: ['Drosophila']


abstract: The @entity238 middle midgut cells derived from the endoderm develop into four distinct types of cell. Of these cells, @entity920 cells have invaginated microvillar membranes on their apical surface, and they are involved in two distinct functions, i.e., @entity920 absorption and acid secretion. The homeobox gene @entity72975 proventriculus (dve) is expressed in the midgut, and two transcripts, type A (   4.9kb) and type B (   3.5kb), have been identified. We isolated the deletion allele dve(E181) that completely removes the first exon for type-A (dve-A) transcript. Dve expression pattern in dve-A mutant background indicates that isoform switching is dynamically regulated in a cell-type specific manner. Using RNAi for dve-A, we examined spatial and temporal requirement of the Dve-A activity. Early Dve-A activity is required to repress isoform switching in @entity920 cells, and for establishment of two gut functions. Late Dve-A activity in @entity920 cells, but not in adjacent interstitial cells, is required for acid secretion, while the activity is redundantly required in both cells for the @entity920 absorptive function. Furthermore, ectopic type-B expression in larval @entity920 cells specifically impaired the @entity920 absorptive function. These results provide insight into molecular mechanisms to establish functional specificity.

title: Spatial and temporal requirement of XXXX proventriculus activity during @entity238 midgut development.

answer: @entity72975 :: (248315,Gene) :: ['defective']


abstract: BACKGROUND: Following @entity583 , individual @entity1 can have wide variations in the extent of @entity1002 ( @entity1002 ) and increased left ventricular (LV) mass. Both affect the risk for @entity1164 , but only LV ejection fraction is used for risk prediction. OBJECTIVE: The purpose of this study was to evaluate the independent as well as the additive contributions of increased LV mass and decreased LV ejection fraction to @entity1164 in the general population. METHODS: In the ongoing Oregon Sudden Unexpected Death Study, we studied consecutive @entity1164 cases (n = 191) and @entity453 controls (n = 203) from the Portland, Oregon, metropolitan area (population approximately 1,000,000; 2002-2008). Comparisons of echocardiographic LV mass obtained prior and unrelated to @entity1164 ( @entity1164 ) were conducted, and a logistic regression model was used to evaluate the relationship between @entity1164 , severe @entity1002 , LV mass, and other relevant clinical variables. RESULTS: In a multivariate model, both severe @entity1002 and @entity4346 ( @entity4346 ) were associated with increased @entity1164 risk (odds ratio [OR] 1.9, 95% confidence interval [CI] 1.1-3.2 for severe @entity1002 ; OR 1.8, 95% CI 1.1-2.9 for @entity4346 ). In @entity1 with coexisting severe @entity1002 and @entity4346 , risk of @entity1164 was additive (OR 3.5, 95% CI 1.7-7.2). In the same model, increased age, @entity955 /flutter, elevated @entity1011 , and @entity6 independently increased risk, and use of angiotensin receptor blockers attenuated risk. CONCLUSION: Reduced LV ejection fraction and increased LV mass had independent and additive effects on risk of @entity944 . Despite the significant overlap between the two conditions, these findings point toward the existence of independent mechanistic pathways for @entity943 that occur due to @entity1002 and @entity4346 .

title: Increased left ventricular mass and decreased left ventricular systolic function have independent pathways to ventricular arrhythmogenesis in XXXX .

entities_list: @entity1164 :: ('MESH:D016757', 'Disease') :: ['sudden cardiac death', 'SCD']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity4346 :: ('MESH:D017379', 'Disease') :: ['left ventricular hypertrophy', 'LVH']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['LVSD', 'left ventricular systolic dysfunction']

answer: @entity453 :: (MESH:D003324,Disease) :: ['coronary artery disease']


abstract: INTRODUCTION: @entity397 is a rare injury which, if missed, leads to delayed surgical treatment and may result in the loss of the knee joint function. The aim of this study was to report our results of operative treatment of the @entity397 and point out the significance of timely diagnosis and surgical procedure. MATERIAL AND METHODS: This retrospective ten-year study included 20 @entity1 , 15 males and 5 females, their mean age being 42 (20-84) years. Seven @entity1 had an injury on the right side and 13 had an injury on the left side. Thirteen @entity1 had the diagnosis set in the first seven days after the injury. The applied techniques were surgical suture of the tendon, bone-tendon-bone ligamentoplasty using allograft from a bone bank and bone-tendon-bone ligamentoplasty using contralateral autograft, and they were performed in 12, 5 and 3 @entity1 , respectively. The treatment results were assessed by using the Lysholm score, measuring the range of movement in the knee joint and measuring the girth of the thigh 10 cm above the patella. RESULTS: The follow-up period after the surgery was 4 years on average (1-10 years) and the average value of the Lysholm score was 83 (27-100). The result was found to be excellent in 11 cases, satisfactory in 5 cases and unsatisfactory in 4. A statistically significant difference (p=0.0197 p<0.05) was found in the average values of the Lysholm score between the group of @entity1 with risk factors (71.78) and the subjects without risk factors (92.18). A statistically significant difference (p=0.008 p<0.01) was found in the Lysholm score between the @entity1 with timely diagnosis (91.62) and cases of chronic tendon tear (67). CONCLUSION: Timely diagnosis and early surgical reparation are the basic imperatives in the treatment of this injury. Comorbidity and risk factors are related to a poorer postoperative Lysholm score. The method of choice is early surgical treatment.

title: XXXX --treatment results.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['Patellar tendon rupture', 'patellar tendon rupture']

answer: @entity397 :: (MESH:D012421,Disease) :: ['Patellar tendon rupture']


abstract: Novel magnetic molecularly imprinted polymer (MIP) beads using @entity38305 as template for use in extraction was developed by microwave heating initiated suspension polymerization. Microwave heating, as an alternative heating source, significantly accelerate the polymerization process. By incorporating magnetic @entity1933 , superparamagnetic composite MIP beads with average diameter of 80  m were obtained. The imprinted beads were then characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, thermogravimetric analysis and vibrating sample magnetometer. Highly cross-linked porous surface and good magnetic property were observed. The adsorption isotherm modeling was performed by fitting the data to Freundlich isotherm model. The binding sites measured were 3.24  mol g(-1) and 1.17  mol g(-1) for the magnetic MIP beads and the corresponding non-imprinted magnetic beads, respectively. Cross-selectivity experiments showed the recognition ability of the magnetic MIP beads to analytes is relative to degree of molecular analogy to the template. Finally, this magnetic MIP bead was successfully used for enrichment of @entity38305 , @entity16825 and @entity7284 from ultrasonically extracted solution of pork and @entity1707 liver followed by high performance chromatography with fluorescence detection. The proposed method presented good linearity and the detection limits was 0.52-1.04 ng mL(-1).The recoveries were from 82.0% to 90.0% and from 80.4% to 86.8% for the spiked pork and @entity1707 liver, respectively, with the RSDs of 5.8-10.0%. Combination of the specific adsorption property of the MIP material and the magnetic separation provided a powerful analytical tool of simplicity, flexibility, and selectivity.

title: Magnetic molecularly imprinted polymer beads prepared by microwave heating for selective enrichment of b-agonists in pork and XXXX liver samples.

entities_list: @entity38305 :: ('MESH:C060897', 'Chemical') :: ['ractopamine']

entities_list: @entity7284 :: ('MESH:D005280', 'Chemical') :: ['fenoterol']

entities_list: @entity1933 :: ('MESH:C000499', 'Chemical') :: ['iron oxide']

entities_list: @entity16825 :: ('MESH:D007556', 'Chemical') :: ['isoxsuprine']

answer: @entity1707 :: (9823,Species) :: ['pig']


abstract: @entity44 ( @entity44 ) are uncommon @entity5 which are usually benign. Our interest was aroused by encountering @entity1 with reportedly benign @entity44 which later, after surgery, recurred as @entity5 . We conducted a retrospective study of 17 @entity1 treated for benign @entity44 during a period of 9 years. Of these @entity1 , 4 developed malignant recurrence (3 females and 1 male) with a mean age of 19 months. The average time to recurrence was 17 months. Recurrence presented as a gluteal mass in one case, urinary and digestive compression signs in another case and as elevated @entity160 levels in the two remaining cases. Histologically, one of the original @entity5 included tiny immature foci but none contained a malignant component after reading slides. Recurrences were as @entity5 in all cases. After surgery and adjuvant chemotherapy, only one @entity1 died from complications related to chemotherapy. The other three were alive and well at mean follow-up of 5 years. These results emphasise the need for close clinical and biological follow-up for at least 2 years in all @entity1 who had undergone excision of a neonatal @entity44 .

title: [Malignant recurrence of "mature" XXXX . A clinicopathological study of 4 cases].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignant tumours', 'endodermal sinus tumour', 'neonatal tumours', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'patients']

entities_list: @entity160 :: ('174', 'Gene') :: ['alpha-fetoprotein']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['Sacrococcygeal teratomas', 'SCT']

answer: @entity44 :: (MESH:D013724,Disease) :: ['sacrococcygeal teratoma']


abstract: OBJECTIVE: To evaluate the efficacy and effectiveness of @entity2144 on 3rd degree haemorrhoids. METHODS: Study was done at Surgical Unit, Civil Hospital Karachi, during a period of 19 months from December 2006 to July 2008. Out of 344 @entity1 80 @entity1 were included in the study with 3rd degree internal haemorrhoids and were treated with Rubber band ligation (RBL). Outcome data was recorded for success of treatment. RESULT: Among 80 @entity1 , 77 (96.25%) were symptom free. After completion of treatment, 1 (16.66%) out of 5 @entity1 had the complaint of @entity158 , 2 (2.85%) out of 70 had complaints of @entity1142 . Before start of treatment 5 (6.25%) @entity1 complained of @entity548 per rectum and 73 (91.25%) complained of manually reducible/prolapsed haemorrhoids. Both complaints were cured 100% after treatment. CONCLUSION: RBL is an efficient, cost-effective and simple out @entity1 procedure for symptomatic @entity3354 with minimum complications. RBL is a reliable, safe procedure requiring no hospitalization and no use of any anaesthetic drugs.

title: A prospective study of outcome from @entity2144 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity3354 :: ('MESH:C565336', 'Disease') :: ['third degree haemorrhoids']

entities_list: @entity2144 :: ('MESH:D020315', 'Disease') :: ['rubber band ligation']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

answer: @entity3354 :: (MESH:C565336,Disease) :: ['third degree haemorrhoids']


abstract: OBJECTIVE: To evaluate the efficacy and effectiveness of @entity2144 on 3rd degree haemorrhoids. METHODS: Study was done at Surgical Unit, Civil Hospital Karachi, during a period of 19 months from December 2006 to July 2008. Out of 344 @entity1 80 @entity1 were included in the study with 3rd degree internal haemorrhoids and were treated with Rubber band ligation (RBL). Outcome data was recorded for success of treatment. RESULT: Among 80 @entity1 , 77 (96.25%) were symptom free. After completion of treatment, 1 (16.66%) out of 5 @entity1 had the complaint of @entity158 , 2 (2.85%) out of 70 had complaints of @entity1142 . Before start of treatment 5 (6.25%) @entity1 complained of @entity548 per rectum and 73 (91.25%) complained of manually reducible/prolapsed haemorrhoids. Both complaints were cured 100% after treatment. CONCLUSION: RBL is an efficient, cost-effective and simple out @entity1 procedure for symptomatic @entity3354 with minimum complications. RBL is a reliable, safe procedure requiring no hospitalization and no use of any anaesthetic drugs.

title: A prospective study of outcome from XXXX in @entity3354 .

answer: @entity2144 :: (MESH:D020315,Disease) :: ['rubber band ligation']


abstract: @entity361 ( @entity361 ) is an early step in the process of @entity5 metastasis. It is well known that @entity5 microenvironment affects @entity189 ; in particular, that @entity519 induces @entity361 . Deregulated notch signaling also contributes a lot to the development of @entity2 . In this study, we investigated the use of @entity125 -inhibiting compound as novel therapeutic candidates to regulate @entity519 -induced @entity2 cells. According to previous screening, @entity44426 was selected as a @entity125 inhibitor. @entity519 -induced @entity361 was characteristic of increased @entity6076 _ @entity2277 expressions and decreased @entity5962 expressions. Treatment with @entity44426 notably attenuated @entity519 -induced @entity361 , invasion and migration in H1299 cells, accompanied with reduced @entity125 , @entity72976 expressions and its downstream genes @entity21507 and @entity1135 . @entity44426 treatment also promoted tumorsuppressive @entity27164 level. Moreover, @entity125 siRNA prevented @entity519 -mediated cell migration and decreased @entity8945 , @entity4245 , and @entity62403 expressions, which are key @entity361 markers. Re-expression of @entity27164 blocked @entity519 -induced @entity361 and cell invasion. Our findings suggest that downregulation of @entity125 and reexpression of @entity27164 by @entity44426 might be a novel remedy for the therapy of @entity2 .

title: XXXX inhibited @entity519 -induced epithelial-mesenchymal transition of @entity2 cells by inactivating of @entity125 signaling and switching on @entity27164 .

entities_list: @entity44426 :: ('MESH:C008661', 'Chemical') :: ['nobiletin', 'Nobiletin']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['EMT in lung cancer', 'lung cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['malignancy in various carcinomas']

entities_list: @entity519 :: ('MESH:D000860', 'Disease') :: ['hypoxia', 'Hypoxia']

entities_list: @entity361 :: ('MESH:C535700', 'Disease') :: ['EMT', 'Epithelial-mesenchymal transition']

answer: @entity44426 :: (MESH:C008661,Chemical) :: ['Nobiletin']


abstract: @entity361 ( @entity361 ) is an early step in the process of @entity5 metastasis. It is well known that @entity5 microenvironment affects @entity189 ; in particular, that @entity519 induces @entity361 . Deregulated notch signaling also contributes a lot to the development of @entity2 . In this study, we investigated the use of @entity125 -inhibiting compound as novel therapeutic candidates to regulate @entity519 -induced @entity2 cells. According to previous screening, @entity44426 was selected as a @entity125 inhibitor. @entity519 -induced @entity361 was characteristic of increased @entity6076 _ @entity2277 expressions and decreased @entity5962 expressions. Treatment with @entity44426 notably attenuated @entity519 -induced @entity361 , invasion and migration in H1299 cells, accompanied with reduced @entity125 , @entity72976 expressions and its downstream genes @entity21507 and @entity1135 . @entity44426 treatment also promoted tumorsuppressive @entity27164 level. Moreover, @entity125 siRNA prevented @entity519 -mediated cell migration and decreased @entity8945 , @entity4245 , and @entity62403 expressions, which are key @entity361 markers. Re-expression of @entity27164 blocked @entity519 -induced @entity361 and cell invasion. Our findings suggest that downregulation of @entity125 and reexpression of @entity27164 by @entity44426 might be a novel remedy for the therapy of @entity2 .

title: @entity44426 inhibited @entity519 -induced epithelial-mesenchymal transition of XXXX cells by inactivating of @entity125 signaling and switching on @entity27164 .

answer: @entity2 :: (MESH:D008175,Disease) :: ['lung cancer']


abstract: @entity361 ( @entity361 ) is an early step in the process of @entity5 metastasis. It is well known that @entity5 microenvironment affects @entity189 ; in particular, that @entity519 induces @entity361 . Deregulated notch signaling also contributes a lot to the development of @entity2 . In this study, we investigated the use of @entity125 -inhibiting compound as novel therapeutic candidates to regulate @entity519 -induced @entity2 cells. According to previous screening, @entity44426 was selected as a @entity125 inhibitor. @entity519 -induced @entity361 was characteristic of increased @entity6076 _ @entity2277 expressions and decreased @entity5962 expressions. Treatment with @entity44426 notably attenuated @entity519 -induced @entity361 , invasion and migration in H1299 cells, accompanied with reduced @entity125 , @entity72976 expressions and its downstream genes @entity21507 and @entity1135 . @entity44426 treatment also promoted tumorsuppressive @entity27164 level. Moreover, @entity125 siRNA prevented @entity519 -mediated cell migration and decreased @entity8945 , @entity4245 , and @entity62403 expressions, which are key @entity361 markers. Re-expression of @entity27164 blocked @entity519 -induced @entity361 and cell invasion. Our findings suggest that downregulation of @entity125 and reexpression of @entity27164 by @entity44426 might be a novel remedy for the therapy of @entity2 .

title: @entity44426 inhibited @entity519 -induced epithelial-mesenchymal transition of @entity2 cells by inactivating of XXXX signaling and switching on @entity27164 .

answer: @entity125 :: (4851,Gene) :: ['Notch-1']


abstract: @entity361 ( @entity361 ) is an early step in the process of @entity5 metastasis. It is well known that @entity5 microenvironment affects @entity189 ; in particular, that @entity519 induces @entity361 . Deregulated notch signaling also contributes a lot to the development of @entity2 . In this study, we investigated the use of @entity125 -inhibiting compound as novel therapeutic candidates to regulate @entity519 -induced @entity2 cells. According to previous screening, @entity44426 was selected as a @entity125 inhibitor. @entity519 -induced @entity361 was characteristic of increased @entity6076 _ @entity2277 expressions and decreased @entity5962 expressions. Treatment with @entity44426 notably attenuated @entity519 -induced @entity361 , invasion and migration in H1299 cells, accompanied with reduced @entity125 , @entity72976 expressions and its downstream genes @entity21507 and @entity1135 . @entity44426 treatment also promoted tumorsuppressive @entity27164 level. Moreover, @entity125 siRNA prevented @entity519 -mediated cell migration and decreased @entity8945 , @entity4245 , and @entity62403 expressions, which are key @entity361 markers. Re-expression of @entity27164 blocked @entity519 -induced @entity361 and cell invasion. Our findings suggest that downregulation of @entity125 and reexpression of @entity27164 by @entity44426 might be a novel remedy for the therapy of @entity2 .

title: @entity44426 inhibited XXXX -induced epithelial-mesenchymal transition of @entity2 cells by inactivating of @entity125 signaling and switching on @entity27164 .

answer: @entity519 :: (MESH:D000860,Disease) :: ['hypoxia']


abstract: @entity361 ( @entity361 ) is an early step in the process of @entity5 metastasis. It is well known that @entity5 microenvironment affects @entity189 ; in particular, that @entity519 induces @entity361 . Deregulated notch signaling also contributes a lot to the development of @entity2 . In this study, we investigated the use of @entity125 -inhibiting compound as novel therapeutic candidates to regulate @entity519 -induced @entity2 cells. According to previous screening, @entity44426 was selected as a @entity125 inhibitor. @entity519 -induced @entity361 was characteristic of increased @entity6076 _ @entity2277 expressions and decreased @entity5962 expressions. Treatment with @entity44426 notably attenuated @entity519 -induced @entity361 , invasion and migration in H1299 cells, accompanied with reduced @entity125 , @entity72976 expressions and its downstream genes @entity21507 and @entity1135 . @entity44426 treatment also promoted tumorsuppressive @entity27164 level. Moreover, @entity125 siRNA prevented @entity519 -mediated cell migration and decreased @entity8945 , @entity4245 , and @entity62403 expressions, which are key @entity361 markers. Re-expression of @entity27164 blocked @entity519 -induced @entity361 and cell invasion. Our findings suggest that downregulation of @entity125 and reexpression of @entity27164 by @entity44426 might be a novel remedy for the therapy of @entity2 .

title: @entity44426 inhibited @entity519 -induced epithelial-mesenchymal transition of @entity2 cells by inactivating of @entity125 signaling and switching on XXXX .

answer: @entity27164 :: (406984,Gene) :: ['miR-200b']


abstract: The article presents the analysis of data of "Study on Global AGEing and Adult Health, 2007-2010" ( @entity12337 ) concerning subjective judging of health, prevalence of @entity63 @entity299 under different levels of arterial pressure in similar age groups. An attempt is made to evaluate spectrum of pharmaceuticals applied in treatment of @entity1 with arterial pressure in hospital at the level of oblast hospital. According official statistics of Minzdrav of Russia, in 20102 prevalence of diseases characterized by higher arterial pressure amounted to 10.5% in adult population and to 22.3% in population older than able-bodied age. At the same time, according @entity12337 data, prevalence of various forms of @entity101 disease in population older than 50 years amounted to 52.8%. That is, this pathology is often missed in conditions of mass medical network. Thereafter, @entity1 receive no necessary medicinal therapy. The one or another treatment was provided to almost 94% of @entity1 with @entity101 disease diagnosed by physician. At that, among @entity1 received treatment the normal levels of both systolic and diastolic pressure were established in less than 20% of @entity1 with @entity101 . Therefore, the issue of effectiveness of applied methods of correction of arterial @entity101 become a matter of interest. The appropriate treatment of @entity101 is a mean to decrease complications and as a result to diminish mortality of diseases of circulatory system.

title: [The evaluation of medicinal therapy under treatment of arterial XXXX in hospital].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: OBJECTIVE: Evaluation of the clinical effectiveness and safety of a new custom-made valgus knee brace (OdrA) in @entity626 ( @entity571 ) in terms of @entity158 and secondary symptoms. METHODS: Open-label prospective study of @entity1 with symptomatic medial knee @entity571 with clinical evaluation at 6 and 52 weeks (W6, W52). We systematically assessed @entity158 on a visual analog scale (VAS), @entity3331 and @entity571 Outcome Score (KOOS), spatio-temporal gait variables, use of nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesic-sparing effects of the brace and tolerance. Mean scores were compared at baseline, W6 and W52 and the effect size (ES) and 95% confidence intervals (95% CIs) were calculated. RESULTS: We included 20 @entity1 with knee @entity571 (mean age 64.2  10.2 years, mean body mass index 27.2  5.4kg/m(2)). @entity227 and KOOS were improved at W6 and W52: @entity158 (ES=0.9 at 1 year), amelioration of other symptoms (ES=0.4), and function in activities of daily living (ES=1.1), sports and leisure (ES=1.5), quality of life (ES=0.9) and gait speed (ES=0.41). In total, 76% of @entity1 showed clinical improvement at 1 year. Analgesic and NSAIDs consumption was significantly decreased at W6 and W52. One serious adverse effect noted was lower-limb varices, and observance was deemed satisfactory at 1 year. CONCLUSION: This new unloader brace appeared to have good effect on medial knee @entity571 , with an acceptable safety profile and good @entity1 compliance.

title: Clinical effectiveness and safety of a distraction-rotation knee brace for XXXX .

entities_list: @entity626 :: ('MESH:D020370', 'Disease') :: ['medial knee osteoarthritis']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['OA', 'Osteoarthritis']

entities_list: @entity3331 :: ('MESH:D007718', 'Disease') :: ['Knee injury']

answer: @entity626 :: (MESH:D020370,Disease) :: ['medial knee osteoarthritis']


abstract: UNASSIGNED: Russian traditional fermented dairy foods have been consumed for thousands of years. However, little research has focused on exploiting @entity880 bacteria (LAB) resources and analyzing the LAB composition of Russian traditional fermented dairy foods. In the present study, we cultured LAB isolated from fermented mare and @entity291 milks, sour cream, and cheese collected from Kalmykiya, Buryats, and Tuva regions of Russia. Seven @entity1336 species and the Bifidobacterium genus were quantified by quantitative PCR. The LAB counts in these samples ranged from 3.18 to 9.77 log cfu/mL (or per gram). In total, 599 LAB strains were obtained from these samples using de @entity1 , Rogosa, and Sharpe agar and M17 agar. The identified LAB belonged to 7 genera and 30 species by 16S rRNA and murE gene sequencing and multiplex PCR assay. The predominant LAB isolates were @entity11070 (176 strains) and @entity1336 (63 strains), which represented 39.9% of all isolates. The quantitative PCR results revealed that counts of 7 lactobacilli species and Bifidobacterium spp. of 30 fermented @entity291 milk samples ranged from 1.19    0.34 ( @entity11070 in Tuva) to 8.09    0.71 ( @entity9206 in Kalmykiya) log cfu/mL of fermented @entity291 milk (mean    standard error). The numbers of Bifidobacterium spp., Lb. plantarum, Lb. helveticus, and Lb. acidophilus revealed no significant difference between the 3 regions; nevertheless, @entity6983 , @entity10688 , @entity5210 , and @entity6043 ssp. bulgaricus exhibited different degrees of variation across 3 regions. The results demonstrate that traditional fermented dairy products from different regions of Russia have complex compositions of LAB species. The diversity of LAB might be related to the type of fermented dairy product, geographical origin, and manufacturing process.

title: Molecular identification and quantification of XXXX bacteria in traditional fermented dairy foods of Russia.

entities_list: @entity11070 :: ('1587', 'Species') :: ['Lactobacillus helveticus']

entities_list: @entity10688 :: ('1613', 'Species') :: ['Lactobacillus fermentum']

entities_list: @entity5210 :: ('1599', 'Species') :: ['Lactobacillus sakei']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactic acid']

entities_list: @entity9206 :: ('1579', 'Species') :: ['Lactobacillus acidophilus']

entities_list: @entity6983 :: ('1597', 'Species') :: ['Lactobacillus paracasei']

entities_list: @entity1336 :: ('1590', 'Species') :: ['Lactobacillus plantarum', 'lactobacillus']

entities_list: @entity6043 :: ('1584', 'Species') :: ['Lactobacillus delbrueckii']

answer: @entity880 :: (MESH:D019344,Chemical) :: ['lactic acid']


abstract: @entity18921 (MK) is a heparin-binding cytokine, and promotes growth, survival, migration and other activities of target cells. After describing the general properties of MK, this review focuses on MK and MK inhibitors as therapeutics for diseases in the central nervous system. MK is strongly expressed during embryogenesis especially at the midgestation period, but is expressed only at restricted sites in adults. MK expression is induced upon tissue injury such as @entity75 . Since exogenously administered MK or the gene transfer of MK suppresses neuronal cell death in experimental systems, MK has the potential to treat @entity385 . MK might become important also in the treatment of @entity179 such as @entity195 . MK is involved in inflammatory diseases by enhancing migration of leukocytes, inducing chemokine production and suppressing regulatory T cells. Since an aptamer to MK suppresses experimental autoimmune @entity198 , MK inhibitors are promising for the treatment of @entity15 . MK is overexpressed in most @entity5 including @entity463 , and is involved in @entity5 invasion. MK inhibitors may be of value in the treatment of @entity463 . Furthermore, an oncolytic adenovirus, whose replication is under the control of the MK promoter, inhibits the growth of @entity463 xenografts. MK inhibitors under development include antibodies, aptamers, glycosaminoglycans, peptides and low molecular weight compounds. siRNA and antisense oligoDNA have proved effective against @entity5 and inflammatory diseases in experimental systems. Practical information concerning the development of MK and MK inhibitors as therapeutics is described in the final part of the review.

title: XXXX : a promising molecule for drug development to treat diseases of the central nervous system.

entities_list: @entity198 :: ('MESH:D004660', 'Disease') :: ['encephalitis']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['ischemic brain damage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'malignant tumors']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases']

entities_list: @entity463 :: ('MESH:D005909', 'Disease') :: ['glioblastoma']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease"]

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity18921 :: (MESH:C068680,Chemical) :: ['Midkine']


abstract: The potential role of the detection of residual @entity715 after @entity1150 ( @entity1150 ) in the differentiation of @entity1 at risk for recurrent @entity1211 ( @entity1211 ) has not yet been fully established and includes different definitions. We performed a systematic review in order to determine the role of residual @entity715 in predicting recurrent @entity1211 after acute proximal @entity1150 . Databases were searched until June 2010. Randomized, controlled trials or prospective cohort studies were eligible for inclusion if they included @entity1 with objectively diagnosed proximal @entity1150 , measured thrombus diameter after at least 3   months and reported recurrent @entity1211 during follow-up. Two authors independently reviewed articles and extracted data. Data from 11 studies were used for the current analysis; in total 3203 @entity1 were included. Residual @entity715 was positively correlated with recurrent @entity1211 . Large heterogeneity was present, due to differences in study population, timing and the differences in method of measuring residual @entity715 . The effect was more pronounced in @entity1 with @entity5 or was dependent on the criteria used. This systematic review shows a positive relationship between residual @entity715 and recurrent @entity1211 during follow-up. Assessing residual @entity715 could be useful in individual recurrence risk estimation.

title: Residual venous thrombosis as predictive factor for recurrent XXXX in @entity1 with proximal @entity1150 : a sytematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity1150 :: ('MESH:D020246', 'Disease') :: ['deep vein thrombosis', 'DVT']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1211 :: ('MESH:D054556', 'Disease') :: ['VTE', 'venous thromboembolism']

answer: @entity1211 :: (MESH:D054556,Disease) :: ['venous thromboembolim']


abstract: The potential role of the detection of residual @entity715 after @entity1150 ( @entity1150 ) in the differentiation of @entity1 at risk for recurrent @entity1211 ( @entity1211 ) has not yet been fully established and includes different definitions. We performed a systematic review in order to determine the role of residual @entity715 in predicting recurrent @entity1211 after acute proximal @entity1150 . Databases were searched until June 2010. Randomized, controlled trials or prospective cohort studies were eligible for inclusion if they included @entity1 with objectively diagnosed proximal @entity1150 , measured thrombus diameter after at least 3   months and reported recurrent @entity1211 during follow-up. Two authors independently reviewed articles and extracted data. Data from 11 studies were used for the current analysis; in total 3203 @entity1 were included. Residual @entity715 was positively correlated with recurrent @entity1211 . Large heterogeneity was present, due to differences in study population, timing and the differences in method of measuring residual @entity715 . The effect was more pronounced in @entity1 with @entity5 or was dependent on the criteria used. This systematic review shows a positive relationship between residual @entity715 and recurrent @entity1211 during follow-up. Assessing residual @entity715 could be useful in individual recurrence risk estimation.

title: Residual venous thrombosis as predictive factor for recurrent @entity1211 in @entity1 with proximal XXXX : a sytematic review.

answer: @entity1150 :: (MESH:D020246,Disease) :: ['deep vein thrombosis']


abstract: The potential role of the detection of residual @entity715 after @entity1150 ( @entity1150 ) in the differentiation of @entity1 at risk for recurrent @entity1211 ( @entity1211 ) has not yet been fully established and includes different definitions. We performed a systematic review in order to determine the role of residual @entity715 in predicting recurrent @entity1211 after acute proximal @entity1150 . Databases were searched until June 2010. Randomized, controlled trials or prospective cohort studies were eligible for inclusion if they included @entity1 with objectively diagnosed proximal @entity1150 , measured thrombus diameter after at least 3   months and reported recurrent @entity1211 during follow-up. Two authors independently reviewed articles and extracted data. Data from 11 studies were used for the current analysis; in total 3203 @entity1 were included. Residual @entity715 was positively correlated with recurrent @entity1211 . Large heterogeneity was present, due to differences in study population, timing and the differences in method of measuring residual @entity715 . The effect was more pronounced in @entity1 with @entity5 or was dependent on the criteria used. This systematic review shows a positive relationship between residual @entity715 and recurrent @entity1211 during follow-up. Assessing residual @entity715 could be useful in individual recurrence risk estimation.

title: Residual venous thrombosis as predictive factor for recurrent @entity1211 in XXXX with proximal @entity1150 : a sytematic review.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Disease severity in @entity1 with @entity613 ( @entity613 ) is often assessed using walking distances and treadmill tests. The aim of this study was to determine the agreement between walking distance as estimated by the @entity1 , as measured during outside walking, and as determined using a nongraded treadmill protocol (NGTP), and an incremental graded ( @entity4511 ) treadmill protocol ( @entity23756 ). METHODS: In this prospective observational study, 30 @entity1 with @entity613 estimated their maximal walking distance (MWD) and completed a "Walking Impairment Questionnaire" (WIQ). Outside walking was determined using a measuring wheel and a @entity23756 controlled device. Primary outcomes were differences in MWD and variability (coefficient of variation, COV). Secondary outcomes were results of WIQ and differences in walking speed. RESULTS: Estimated walking distance was significantly higher than MWD as objectively measured during outside walking (400 m vs. 309 m, respectively, P  =  0.02). A substantial variability (COV  =  55%) was found between both parameters. A small 35-m MWD difference between outside walking and @entity23756 was found with a substantial scatter (COV  =  42%). In contrast, a much larger 122-m MWD difference was present between outside walking and NGTP (COV = 89%). @entity1 walked significantly faster in the open air than on treadmills (median outside walking speed  =  3.8  km/hr, @entity23756  =  3.2  km/hr, NGTP  =  2.8  km/hr; P  <  0.001). CONCLUSIONS: An incremental graded ( @entity4511 ) treadmill protocol demonstrated the best agreement to outside walking. Discrepancies between treadmill tests and outside walking may be explained by a difference in walking speed. A single determination of a walking distance is a poor reflection of true walking capacity.

title: Agreements and Discrepancies between the  Estimated Walking Distance, Nongraded and Graded Treadmill Testing, and Outside Walking in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity613 :: ('MESH:D007383', 'Disease') :: ['intermittent claudication', 'IC']

entities_list: @entity4511 :: ('MESH:D005736', 'Disease') :: ['Gardner-Skinner']

answer: @entity613 :: (MESH:D007383,Disease) :: ['Intermittent Claudication']


abstract: BACKGROUND: Disease severity in @entity1 with @entity613 ( @entity613 ) is often assessed using walking distances and treadmill tests. The aim of this study was to determine the agreement between walking distance as estimated by the @entity1 , as measured during outside walking, and as determined using a nongraded treadmill protocol (NGTP), and an incremental graded ( @entity4511 ) treadmill protocol ( @entity23756 ). METHODS: In this prospective observational study, 30 @entity1 with @entity613 estimated their maximal walking distance (MWD) and completed a "Walking Impairment Questionnaire" (WIQ). Outside walking was determined using a measuring wheel and a @entity23756 controlled device. Primary outcomes were differences in MWD and variability (coefficient of variation, COV). Secondary outcomes were results of WIQ and differences in walking speed. RESULTS: Estimated walking distance was significantly higher than MWD as objectively measured during outside walking (400 m vs. 309 m, respectively, P  =  0.02). A substantial variability (COV  =  55%) was found between both parameters. A small 35-m MWD difference between outside walking and @entity23756 was found with a substantial scatter (COV  =  42%). In contrast, a much larger 122-m MWD difference was present between outside walking and NGTP (COV = 89%). @entity1 walked significantly faster in the open air than on treadmills (median outside walking speed  =  3.8  km/hr, @entity23756  =  3.2  km/hr, NGTP  =  2.8  km/hr; P  <  0.001). CONCLUSIONS: An incremental graded ( @entity4511 ) treadmill protocol demonstrated the best agreement to outside walking. Discrepancies between treadmill tests and outside walking may be explained by a difference in walking speed. A single determination of a walking distance is a poor reflection of true walking capacity.

title: Agreements and Discrepancies between the  Estimated Walking Distance, Nongraded and Graded Treadmill Testing, and Outside Walking in XXXX with @entity613 .

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: INTRODUCTION: Operative laparoscopy is the most common used technique for treatment of @entity1 with @entity43 , because of many positive effects in comparison with laparotomy. There are many laparoscopic techniques, but most used are cystectomy and puncture with endocoagulation (ablation) of the cyst's capsule. The aim of this study was to evaluate the effect of two laparoscopic techniques for treatment of @entity43 on ovarian reserve. We used two ultrasonographic markers for ovarian reserve: ovarian volume and antral follicle count (AFC). MATERIALS AND METHODS: Sixty @entity1 in reproductive age (18-42 years) were treated for a chronic pelvic @entity158 or @entity249 in a tertiary hospital (University Clinic for Gynecology and Obstetrics in Skopje, R. Macedonia). The study was prospective and two laparoscopic techniques were used. All @entity1 were with confirmed ultrasound diagnosis for @entity43 with diameter between 3 and 8 cm. Complete cystectomy was done in 30 @entity1 (group A) and puncture with endocoagulation was done in other 30 @entity1 (group B). Ovarian reserve was analyzed before surgery and was controlled one and three months after laparoscopic surgery. RESULTS: In group A (operated with cystectomy) ovarian volume was 53.46  29.97 cm   before surgery, which fell to 13.06  7.34 cm   after one month, and 13.28  7.17 cm   after three months. Statistical analysis showed a significant @entity2670 and three months after surgery (p <=0.01). In group B (operated with puncture and endocoagulation) the ovarian volume was 58.34  37.99 cm   before surgery, which fell to 18.96  7.90 cm   one month and 17.38  6.86 cm   three months after surgery. In both groups there was a significant @entity2670 and three months postoperatively (p <=0.01). In the first group AFC was 3.03  1.27 before surgery, 4.8  1.30 one month after surgery and 6.23  1.57 after three months. Statistical analysis showed a significant increase in AFC after laparoscopic cystectomy (p <=0.01). In the second group AFC was 3.07  1.05 before surgery, 5.33  1.60 after one month and 7.0  1.62 after three months. The comparison of AFC showed high statistically significant difference (p <=0.001), e.g. increase of AFC after one and three months in comparison with AFC before surgery. CONCLUSIONS: Ovarian reserve decreases after laparoscopic surgery using both laparoscopic techniques. But, this decrease was more frequent using cystectomy in comparison with ablation of the @entity45 .

title: Effect of Two Laparoscopic Techniques for Treatment of XXXX on Ovarian Reserve.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian endometriomas']

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity45 :: ('MESH:D010181', 'Disease') :: ['endometriotic cyst']

entities_list: @entity2670 :: ('MESH:D010049', 'Disease') :: ['reduction in ovarian volume one']

answer: @entity43 :: (MESH:D010051,Disease) :: ['Ovarian Endometrioma']


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity458 are registered during the use of selective @entity750 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity204 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity906 , @entity3659 and @entity903 . MATERIAL AND METHODS: The study included 90 in- @entity1 as well as outpatients of both sexes aged 18-65 who were treated for major @entity308 at Psychiatric Clinic in Banjaluka. 30 @entity1 were treated with @entity3659 75-250 mg, 30 @entity1 were treated with @entity903 20-40 mg and 30 @entity1 were treated with @entity906 75-300 mg. The selection of @entity1 was done on the basis of diagnosis of major @entity308 . RESULTS: Most @entity1 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity903 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of @entity906 , @entity903 and @entity3659 in XXXX Therapy.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorder']

entities_list: @entity3659 :: ('MESH:D000639', 'Chemical') :: ['amitriptyline']

entities_list: @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual side effects']

entities_list: @entity750 :: ('MESH:D012701', 'Chemical') :: ['serotonin']

entities_list: @entity906 :: ('MESH:C047426', 'Chemical') :: ['venlafaxine']

answer: @entity308 :: (MESH:D003866,Disease) :: ['Depression']


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity458 are registered during the use of selective @entity750 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity204 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity906 , @entity3659 and @entity903 . MATERIAL AND METHODS: The study included 90 in- @entity1 as well as outpatients of both sexes aged 18-65 who were treated for major @entity308 at Psychiatric Clinic in Banjaluka. 30 @entity1 were treated with @entity3659 75-250 mg, 30 @entity1 were treated with @entity903 20-40 mg and 30 @entity1 were treated with @entity906 75-300 mg. The selection of @entity1 was done on the basis of diagnosis of major @entity308 . RESULTS: Most @entity1 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity903 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of XXXX , @entity903 and @entity3659 in @entity308 Therapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

answer: @entity906 :: (MESH:C047426,Chemical) :: ['Venlafaxine']


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity458 are registered during the use of selective @entity750 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity204 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity906 , @entity3659 and @entity903 . MATERIAL AND METHODS: The study included 90 in- @entity1 as well as outpatients of both sexes aged 18-65 who were treated for major @entity308 at Psychiatric Clinic in Banjaluka. 30 @entity1 were treated with @entity3659 75-250 mg, 30 @entity1 were treated with @entity903 20-40 mg and 30 @entity1 were treated with @entity906 75-300 mg. The selection of @entity1 was done on the basis of diagnosis of major @entity308 . RESULTS: Most @entity1 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity903 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of @entity906 , @entity903 and XXXX in @entity308 Therapy.

answer: @entity3659 :: (MESH:D000639,Chemical) :: ['Amitriptyline']


abstract: INTRODUCTION: There are no controlled studies dedicated to research of side effects of antidepressants. It is a well known fact that antidepressants reciprocally differ according to their type, intensity and frequency of appearance of certain side effects. For example, cardiovascular and anticholinergic effects are essential feature of the tricyclics whereas gastrointestinal and @entity458 are registered during the use of selective @entity750 reuptake inhibitors. Interruptions of therapy or irregular use of drugs because of the appearance of side effects are not rare. Serious side effects of drugs are the fourth cause of @entity204 in the USA. AIM: The aim of this study is the evaluation of appearance of side effects comparing three different groups of antidepressants: @entity906 , @entity3659 and @entity903 . MATERIAL AND METHODS: The study included 90 in- @entity1 as well as outpatients of both sexes aged 18-65 who were treated for major @entity308 at Psychiatric Clinic in Banjaluka. 30 @entity1 were treated with @entity3659 75-250 mg, 30 @entity1 were treated with @entity903 20-40 mg and 30 @entity1 were treated with @entity906 75-300 mg. The selection of @entity1 was done on the basis of diagnosis of major @entity308 . RESULTS: Most @entity1 did not have serious side effects. The study confirmed high efficiency of the mentioned drugs as well as the fact that @entity903 causes a bit more side effects in comparison with two other antidepressants.

title: Comparison of Tolerance of @entity906 , XXXX and @entity3659 in @entity308 Therapy.

answer: @entity903 :: (MESH:D017374,Chemical) :: ['Paroxetine']


abstract: The purpose of the use of this methodology is 1) to advance our capacity to protect individuals with antibody or vaccine for preventing or treating @entity3219 caused by the fungus @entity3218 and 2) to examine the role of virulence factors as target for therapy. To generate mAbs, @entity19 are immunized, the immune responses are assessed using a solid phase ELISA system developed in our laboratory, and the best responder @entity19 are selected for isolation of splenocytes for fusion with hybridoma cells. C57BL/6 @entity19 have been extensively used to study @entity3218 pathogenesis and provide the best model for obtaining the data required. In order to assess the role of the mAbs in @entity281 , @entity19 are intraperitoneally administered with either mAb to @entity3218 or isotype matched control mAb and then infected by either intravenous (i.v.), intraperitoneal (i.p.), or intranasal (i.n.) routes. In the scientific literature, efficacy of mAbs for @entity364 in @entity19 relies on mortality as an end point, in conjunction with colony forming units (CFU) assessments at earlier time points. Survival (time to death) studies are necessary as they best represent @entity1 disease. Thus, efficacy of our intervention would not adequately be established without survival curves. This is also true for establishing efficacy of vaccine or testing of mutants for virulence. With @entity3219 , the @entity19 often go from being energetic to dead over several hours. The capacity of an intervention such as the administration of a mAb may initially protect an animal from disease, but the disease can relapse which would not be realized in short CFU experiments. In addition to survival and fungal burden assays, we examine the inflammatory responses to @entity281 (histology, cellular recruitment, cytokine responses). For survival/time to death experiments, the @entity19 are infected and monitored at least twice daily for signs of morbidity. To assess fungal burden, histopathology, and cytokine responses, the @entity19 are euthanized at various times after @entity281 . Animal experiments are performed according to the guidelines of the Institute for Animal Studies of the Albert Einstein College of Medicine.

title: Passive administration of monoclonal antibodies against XXXX and other fungal pathogens.

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity364 :: ('MESH:D009181', 'Disease') :: ['fungal infections']

entities_list: @entity3218 :: ('5037', 'Species') :: ['Histoplasma capsulatum', 'H. capsulatum']

entities_list: @entity3219 :: ('MESH:D006660', 'Disease') :: ['histoplasmosis']

answer: @entity3218 :: (5037,Species) :: ['H. capsulatum']


abstract: For some moth species, especially those closely interrelated and sympatric, recognizing a specific @entity5681 component concentration ratio is essential for males to successfully locate conspecific females. We propose and determine the properties of a minimalist competition-based feed-forward neuronal model capable of detecting a certain ratio of @entity5681 components independently of overall concentration. This model represents an elementary recognition unit for the ratio of binary mixtures which we propose is entirely contained in the macroglomerular complex (MGC) of the male moth. A set of such units, along with projection neurons (PNs), can provide the input to higher brain centres. We found that (1) accuracy is mainly achieved by maintaining a certain ratio of connection strengths between olfactory receptor neurons (ORN) and @entity528 ( @entity528 ), much less by properties of the interconnections between the competing LNs proper. An exception to this rule is that it is beneficial if connections between generalist LNs (i.e. excited by either @entity5681 component) and specialist LNs (i.e. excited by one component only) have the same strength as the reciprocal specialist to generalist connections. (2) successful ratio recognition is achieved using latency-to-first-spike in the @entity528 populations which, in contrast to expectations with a population rate code, leads to a broadening of responses for higher overall concentrations consistent with experimental observations. (3) when longer durations of the competition between LNs were observed it did not lead to higher recognition accuracy.

title: Competition-based model of XXXX component ratio detection in the moth.

entities_list: @entity5681 :: ('CHEBI:26013', 'Chemical') :: ['pheromone']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['local neurons', 'LN']

answer: @entity5681 :: (CHEBI:26013,Chemical) :: ['pheromone']


abstract: OBJECTIVE: After solid organ transplantation, risk of @entity5 varies significantly based on @entity5 type. In this study, we determine the incidence of @entity5 (bladder and kidney) after renal transplantation from a single high-volume transplantation institution. In addition, we analyze the risk factors and review outcomes from the @entity1 . MATERIALS AND METHODS: We performed a retrospective review of all @entity1 in the University of Alabama at Birmingham (UAB) transplant database to identify all @entity1 who received renal transplants at UAB between January 1, 1990, and January 1, 2010. We further identified transplant @entity1 diagnosed with bladder, urothelial of other @entity5 in the same time period. We also examined @entity5 -specific variables such as presentation, clinical and pathologic staging, treatment type, recurrence, progression, interval to recurrence and progression, @entity5 -specific mortality, and interval from time to diagnosis to @entity204 . RESULTS: Review of the transplant database confirmed 5,920 renal transplants. Thirteen @entity1 underwent the diagnosis of @entity5 , providing an incidence of 0.2%. Eight @entity1 had @entity150 for an incidence of 0.13%, compared to an incidence of 0.02% among the general population. @entity1 diagnosed with @entity150 after renal transplantation were younger than those in the general population and frequently present with more advanced and @entity146 . CONCLUSIONS: @entity1 are at an elevated risk of @entity5 after renal transplantation probably from immune suppression.

title: XXXX after renal transplantation.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressive disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers', 'urothelial cancers', 'cancer', 'urothelial cancer']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Urothelial cancers']


abstract: AIMS: To test a simulation model, the MICADO model, for estimating the long-term effects of interventions in @entity1 with and without @entity6 . METHODS: The MICADO model includes micro- and @entity66 in relation to their risk factors. The strengths of this model are its population scope and the possibility to assess parameter uncertainty using probabilistic sensitivity analyses. Outcomes include incidence and prevalence of complications, quality of life, costs and cost-effectiveness. We externally validated MICADO's estimates of micro- and macrovascular complications in a Dutch cohort with @entity6 (n  =  498 400) by comparing these estimates with national and international empirical data. RESULTS: For the annual number of @entity1 undergoing amputations, MICADO's estimate was 592 (95% interquantile range 291-842), which compared well with the registered number of @entity1 with @entity6 -related amputations in the Netherlands (728). The incidence of @entity454 estimated using the MICADO model was 247 @entity1 (95% interquartile range 120-363), which was also similar to the registered incidence in the Netherlands (277 @entity1 ). MICADO performed well in the validation of macrovascular outcomes of population-based cohorts, while it had more difficulty in reflecting a highly selected trial population. CONCLUSIONS: Validation by comparison with independent empirical data showed that the MICADO model simulates the natural course of @entity6 and its micro- and macrovascular complications well. As a population-based model, MICADO can be applied for projections as well as scenario analyses to evaluate the long-term (cost-)effectiveness of population-level interventions targeting @entity6 and its complications in the Netherlands or similar countries.

title: Policy evaluation in XXXX prevention and treatment using a population-based macro simulation model: the MICADO model.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['macrovascular diseases']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['end-stage renal disease']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: OBJECTIVE: To identify the presence of orexin receptor 1 (OXR1) in @entity28 @entity35 pancreas and clarify its effect and mechanism on body weight and metabolic index in @entity28 @entity35 . METHODS: The @entity28 @entity35 model was established a high-fat diet. And the serum levels of @entity413 , @entity412 and insulin were measured by Mini-Blood @entity413 meter, biochemical enzymatic method and chemiluminescent immunoassay. The pancreatic expression of @entity24210 protein was identified by immunohistochemistry. After an intracerebroventricular infusion of orexin receptor 1 antisense oligodeoxynucleotide ( @entity24210 -PS-ODNs), the effect on @entity24210 protein was detected in @entity35 pancreatic tissue with @entity28 . RESULTS: After feeding for 8 weeks, high-fat diet @entity35 appear @entity28 body weight, serum @entity413 , insulin, @entity412 and @entity165 of high-diet @entity35 were higher than those in the control group (P < 0.05). The expression of @entity24210 protein was located in the cytoplasm of pancreas Islet b-cells. The expression of @entity24210 protein in @entity28 @entity35 pancreas decreased around 16% versus the normal group (P < 0.05). After the @entity28 @entity35 were treated by @entity24210 -PS-ODNs for 72 hours, the expression of @entity24210 protein in pancreas declined from 82    6 to 65    4, reduced about 21% compare with control group (P < 0.01). CONCLUSION: The expression of @entity24210 protein is found in pancreas Islet b-cells. Hypothalamic orexin system can intervene the expression of @entity24210 protein in @entity35 pancreatic tissue with @entity28 . And it may participate in the occurrence of @entity28 and the metabolic regulation of serum @entity413 and insulin.

title: [Expression of orexin receptor 1 in @entity35 pancreatic tissue with XXXX ].

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['alimentary obesity', 'obese', 'obesity']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['triglyceride']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose', 'Glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity28 :: (MESH:D009765,Disease) :: ['alimentary obesity']


abstract: OBJECTIVE: To identify the presence of orexin receptor 1 (OXR1) in @entity28 @entity35 pancreas and clarify its effect and mechanism on body weight and metabolic index in @entity28 @entity35 . METHODS: The @entity28 @entity35 model was established a high-fat diet. And the serum levels of @entity413 , @entity412 and insulin were measured by Mini-Blood @entity413 meter, biochemical enzymatic method and chemiluminescent immunoassay. The pancreatic expression of @entity24210 protein was identified by immunohistochemistry. After an intracerebroventricular infusion of orexin receptor 1 antisense oligodeoxynucleotide ( @entity24210 -PS-ODNs), the effect on @entity24210 protein was detected in @entity35 pancreatic tissue with @entity28 . RESULTS: After feeding for 8 weeks, high-fat diet @entity35 appear @entity28 body weight, serum @entity413 , insulin, @entity412 and @entity165 of high-diet @entity35 were higher than those in the control group (P < 0.05). The expression of @entity24210 protein was located in the cytoplasm of pancreas Islet b-cells. The expression of @entity24210 protein in @entity28 @entity35 pancreas decreased around 16% versus the normal group (P < 0.05). After the @entity28 @entity35 were treated by @entity24210 -PS-ODNs for 72 hours, the expression of @entity24210 protein in pancreas declined from 82    6 to 65    4, reduced about 21% compare with control group (P < 0.01). CONCLUSION: The expression of @entity24210 protein is found in pancreas Islet b-cells. Hypothalamic orexin system can intervene the expression of @entity24210 protein in @entity35 pancreatic tissue with @entity28 . And it may participate in the occurrence of @entity28 and the metabolic regulation of serum @entity413 and insulin.

title: [Expression of orexin receptor 1 in XXXX pancreatic tissue with @entity28 ].

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: OBJECTIVE: To evaluate the characteristics of papillary structure of @entity1374 on MSCT (multiple-slice spiral computed tomography) for the diagnosis of @entity1374 . METHODS: Thirty-five cases of @entity1374 pathologically confirmed with plain and contrast MSCT data from March 2003 to April 2010 were retrospectively analyzed. The number, margin, shape, enhancement behavior, location, @entity730 and the delineation of papillary structure were compared by the stata 10.1 software. RESULTS: There were statistically significant differences between @entity259 , @entity259 and @entity8170 in margin, shape and location of papillary structure (P < 0.05). @entity3557 was most commonly located in central part with an indistinct margin. Psammoma, such as microcalcification, was characteristic of @entity259 . Coarse and peripheral @entity730 was commonly observed in @entity8170 . No statistical difference existed in the number and internal septa of papillary structure among @entity259 , @entity259 and @entity8170 (P > 0.05). It could offer a more distinct visualization of papillary structure during the venous phase. CONCLUSION: The features of papillary structure on MSCT of various @entity1374 may help make the differential diagnosis of @entity1374 .

title: [Characteristics of papillary structure of XXXX on multiple-slice spiral computed tomography for the diagnosis of @entity1374 ].

entities_list: @entity8170 :: ('MESH:D006044', 'Disease') :: ['nodular goiter']

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['Papillary structure of thyroidal carcinoma']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroidal adenoma', 'thyroidal cancer', 'thyroidal carcinoma']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroidal lesions', 'thyroidal diseases']

answer: @entity1374 :: (MESH:D013959,Disease) :: ['thyroidal lesions']


abstract: OBJECTIVE: To evaluate the characteristics of papillary structure of @entity1374 on MSCT (multiple-slice spiral computed tomography) for the diagnosis of @entity1374 . METHODS: Thirty-five cases of @entity1374 pathologically confirmed with plain and contrast MSCT data from March 2003 to April 2010 were retrospectively analyzed. The number, margin, shape, enhancement behavior, location, @entity730 and the delineation of papillary structure were compared by the stata 10.1 software. RESULTS: There were statistically significant differences between @entity259 , @entity259 and @entity8170 in margin, shape and location of papillary structure (P < 0.05). @entity3557 was most commonly located in central part with an indistinct margin. Psammoma, such as microcalcification, was characteristic of @entity259 . Coarse and peripheral @entity730 was commonly observed in @entity8170 . No statistical difference existed in the number and internal septa of papillary structure among @entity259 , @entity259 and @entity8170 (P > 0.05). It could offer a more distinct visualization of papillary structure during the venous phase. CONCLUSION: The features of papillary structure on MSCT of various @entity1374 may help make the differential diagnosis of @entity1374 .

title: [Characteristics of papillary structure of @entity1374 on multiple-slice spiral computed tomography for the diagnosis of XXXX ].

answer: @entity1374 :: (MESH:D013959,Disease) :: ['thyroidal diseases']


abstract: OBJECTIVES/HYPOTHESIS: To examine associations between quality of care, short- and long-term treatment-related outcomes, and costs in elderly @entity1 treated for @entity1544 ( @entity1544 ). STUDY DESIGN: Retrospective analysis of Surveillance, Epidemiology, and End Results-Medicare data. METHODS: We evaluated longitudinal data from 2,370 @entity1 diagnosed with laryngeal @entity1544 from 2004 to 2007 using cross-tabulations, multivariate regression, and survival analysis. Using quality indicators derived from guidelines for recommended care and performance measures, an overall summary measure of quality was calculated incorporating summary quality measures for diagnosis, initial treatment, performance, surveillance, treatment for recurrence, and end-of-life care. RESULTS: Higher-quality care was associated with a lower likelihood of long-term @entity353 (odds ratio [OR]   =   0.6 [0.5-0.8]), stricture (OR   =   0.5 [0.3-0.8]), @entity734 (OR   =   0.5 [0.4-0.7]), @entity1224 (OR   =   0.7 [0.6-0.9]), tracheostomy (OR   =   0.5 [0.3-0.7]), and @entity55 (OR   =   0.7 [0.5-0.9]), but had no impact on the likelihood of @entity1282 . Higher-quality care was associated with lower risk of @entity204 in @entity1 with @entity1282 (hazard ratio [HR]   =   0.7 [0.6-0.8]), @entity353 (HR   =   0.8 [0.6-0.9]), @entity1224 (HR   =   0.7 [0.6-0.8]), tracheostomy (HR   =   0.7 [0.5-0.9]), and @entity55 (HR   =   0.8 [0.6-0.9]), but was not associated with survival differences in @entity1 with @entity734 or stricture. Costs associated with @entity1282 , @entity353 , stricture, @entity1224 , and @entity55 were lower for @entity1 receiving higher-quality care. CONCLUSIONS: Higher-quality @entity5 care was associated with a reduced incidence of late airway and swallowing impairment after laryngeal @entity1544 treatment in elderly @entity1 , with improved survival and reduced costs. These data suggest that greater attention to evidence-based practices associated with quality indicators may lead to improved functional outcomes in the elderly. LEVEL OF EVIDENCE: 2c.

title: Quality of care and short- and long-term outcomes of XXXX care in the elderly.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['larynx cancer']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['laryngeal squamous cell cancer', 'SCCA']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['gastrostomy dependence']

entities_list: @entity1224 :: ('MESH:D000402', 'Disease') :: ['airway obstruction']

answer: @entity5 :: (MESH:D009369,Disease) :: ['laryngeal cancer']


abstract: BACKGROUND: @entity195 ( @entity195 ) is associated with @entity528 , yet the underlying pathophysiology of this disease and the @entity1781 remain poorly understood. Low-density lipoprotein receptor-related protein ( @entity8993 ) is implicated in the pathogenesis of @entity195 by mediating the transport of amyloid-b (Ab) out of the brain into the systemic circulation. As a key player in the reaction to central @entity4215 , astrocytes associate with @entity8993 in @entity195 . This study investigates the role of @entity8993 and astrocytes in the pathogenesis of @entity1781 . METHODS: To investigate the role of @entity8993 and astrocytes in the pathogenesis of @entity1781 , we conducted immunohistochemical studies on postmortem optic nerves in @entity195 @entity1 (n = 11) and age-matched controls (n = 10) to examine the presence of @entity8993 . Quantitative analyses using imaging software were used to document the extent of @entity8993 in neural tissues. Axonal integrity was assessed by performing immunohistochemistry on the subjects' optic nerves with an antibody to neurofilament (NF) protein. Double-immunofluorescence labeling was performed to investigate whether @entity8993 colocalized with astrocytes, expressing glial fibrillary acidic protein. RESULTS: @entity8993 expression was decreased in @entity195 optic nerves compared to that in controls (P < 0.001). @entity8993 immunoreactivity was observed in the microvasculature and perivascularly in close proximity to the astrocytic processes. Colocalization of @entity8993 in the astrocytes of optic nerves was also demonstrated. The presence of @entity1781 was confirmed in the @entity195 optic nerves by demonstrating greatly reduced immunostaining for NF protein as compared to controls. CONCLUSIONS: The reduction of @entity8993 in the @entity1781 supports the hypothesis that @entity8993 may play a role in the pathophysiology of @entity1781 .

title: Low-density lipoprotein receptor-related protein is decreased in XXXX of @entity195 .

entities_list: @entity4215 :: ('MESH:D020196', 'Disease') :: ['nervous system injury']

entities_list: @entity1781 :: ('MESH:D009901', 'Disease') :: ['optic neuropathy', 'optic nerve disorder', 'AD optic neuropathy', 'AD degenerative optic nerves']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'Alzheimer disease']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['optic nerve degeneration']

answer: @entity1781 :: (MESH:D009901,Disease) :: ['optic neuropathy']