abstract: UNASSIGNED: Due to numerous industrial applications, lead has caused widespread pollution in the environment; it seems that the central nervous system (CNS) is the main target for lead in the @entity1 body. Oxidative stress and programmed cell death in the CNS have been assumed as two mechanisms related to @entity2359 of lead. Cerium oxide (CeO2) and yttrium oxide (Y2O3) nanoparticles have recently shown antioxidant effects, particularly when used together, through scavenging the amount of reactive oxygen species (ROS) required for cell apoptosis. We looked into the neuroprotective effects of the combinations of these nanoparticles against acute lead-induced @entity2359 in @entity35 hippocampus. We used five groups in this study: control, lead, CeO2 nanoparticles + lead, Y2O3 nanoparticles + lead, and CeO2 and Y2O3 nanoparticles + lead. Nanoparticles of CeO2 (1000  mg/kg) and Y2O3 (230  mg/kg) were administered intraperitoneally during 2  days prior to intraperitoneal injection of the lead (25  mg/kg for 3  days). At the end of the treatments, oxidative stress markers, antioxidant enzymes activity, and apoptosis indexes were investigated. The results demonstrated that pretreatments with CeO2 and/or Y2O3 nanoparticles recovered lead-caused oxidative stress markers (ROS, lipid peroxidation, and total thiol molecules) and apoptosis indexes ( @entity2310 / @entity1976 and @entity4124 protein expression). Besides, these nanoparticles reduced the activities of lead-induced superoxide dismutase and @entity12609 as well as the ADP/ATP ratio. Interestingly, the best recovery resulted from the compound of these nanoparticles. Based on these outcomes, it appears that this combination may potentially be beneficial for protection against lead-caused acute @entity137 in the brain through improving the oxidative stress-mediated programmed cell death pathway.

title: Cerium and Yttrium Oxide Nanoparticles Against Lead-Induced Oxidative Stress and Apoptosis in XXXX Hippocampus.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity35 :: (10116,Species) :: ['Rat']


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity66 , like @entity65 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7066 --63G>A ( @entity71795 ) and @entity2215 --1327C>T ( @entity41070 ), on the whole spectrum of acute @entity453 . METHODS: We studied 150 middle aged @entity1 admitted for an @entity1187 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity2215 polymorphism was more prevalent among @entity101 @entity1 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity453 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity101 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity453 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity1187 .

title: The role of the @entity7066 -63g>a and @entity2215 -1327c>t telomerase polymorphisms in the study of @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'men']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['related diseases']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension', 'hypertensive']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity1187 :: (MESH:D054058,Disease) :: ['acute coronary syndrome']


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity66 , like @entity65 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7066 --63G>A ( @entity71795 ) and @entity2215 --1327C>T ( @entity41070 ), on the whole spectrum of acute @entity453 . METHODS: We studied 150 middle aged @entity1 admitted for an @entity1187 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity2215 polymorphism was more prevalent among @entity101 @entity1 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity453 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity101 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity453 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity1187 .

title: The role of the @entity7066 -63g>a and XXXX -1327c>t telomerase polymorphisms in the study of @entity1 with @entity1187 .

answer: @entity2215 :: (7015,Gene) :: ['tert']


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity66 , like @entity65 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7066 --63G>A ( @entity71795 ) and @entity2215 --1327C>T ( @entity41070 ), on the whole spectrum of acute @entity453 . METHODS: We studied 150 middle aged @entity1 admitted for an @entity1187 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity2215 polymorphism was more prevalent among @entity101 @entity1 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity453 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity101 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity453 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity1187 .

title: The role of the XXXX -63g>a and @entity2215 -1327c>t telomerase polymorphisms in the study of @entity1 with @entity1187 .

answer: @entity7066 :: (7012,Gene) :: ['terc']


abstract: AIM: Telomerase is a ribonucleoprotein that maintains telomere length. Telomeres and telomerase are involved in cellular ageing and have been connected to some aging @entity66 , like @entity65 . Telomerase dysfunction could be the main underlying mechanism in this connection but this point is still unclear. The aim of this article is to investigate the possible influence of cellular ageing, measured by two telomerase polymorphisms, @entity7066 --63G>A ( @entity71795 ) and @entity2215 --1327C>T ( @entity41070 ), on the whole spectrum of acute @entity453 . METHODS: We studied 150 middle aged @entity1 admitted for an @entity1187 . Cardiovascular risk factors prevalence was collected at admission. Severity variables analyzed were Killip class and number of vessels affected. Telomerase polymorphisms were studied by real time PCR in DNA samples extracted from peripheral blood leukocytes. Clinical follow up had been developed for more than 600 days and a prognostic combined event was defined. RESULTS: C allele of @entity2215 polymorphism was more prevalent among @entity101 @entity1 (OR: 3.19; 95% CI: 1.37-7.42; p= 0.006). None of polymorphisms showed any prognostic value or relation to @entity453 severity. CONCLUSION: Telomerase dysfunction could be involved in @entity101 prevalence. This finding could support new screening strategies in high risk population. The two telomerase polymorphisms analyzed did not show any prognostic value or connection to @entity453 severity. However, further studies are required to determine the molecular mechanisms responsible for cellular ageing in @entity1187 .

title: The role of the @entity7066 -63g>a and @entity2215 -1327c>t telomerase polymorphisms in the study of XXXX with @entity1187 .

answer: @entity1 :: (9606,Species) :: ['men']


abstract: Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in @entity1 with @entity571 and @entity174 of the femoral neck are described. Femoral heads were obtained from @entity1 who had surgery for the treatment of @entity2249 or total hip replacement for advanced @entity571 . Blocks from the principal compressive region of a coronal slice were sampled systematically to prepare 10 microns sections for automated analysis. There was no significant difference in the mineral bone content of the osteoarthritic (OA) and @entity2249 ( @entity2249 ) cases or between males and females for each group. The regression of mineralized bone on age was significant for OA data, showing a decrease in mineralized bone volume with age, whereas there was no significant relationship for the @entity2249 data. Surface density was significantly lower in the OA group than in the @entity2249 group despite the fact there is no difference in the mineralized bone. The regression of surface density on age was not statistically significant in both groups, although regression of surface density on the mineralized bone was significant for both groups and demonstrated that OA cases generated less surface than @entity2249 cases for the same amount of mineralized bone volume. The trabeculae in OA were significantly thicker than in @entity2249 , and spacing in OA was significantly greater than in @entity2249 . The regression of trabecular thickness and spacing on age was not significant for either OA or @entity2249 . For OA, thickness and spacing showed a significant regression on the mineralized bone volume, positive and negative, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Histomorphometric changes in the trabecular structure of a selected stress region in the femur in @entity1 with XXXX and @entity174 of the femoral neck.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2249 :: ('MESH:D005265', 'Disease') :: ['femoral neck fracture', 'FNOF', 'fractured neck of femur']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

answer: @entity571 :: (MESH:D010003,Disease) :: ['osteoarthritis']


abstract: Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in @entity1 with @entity571 and @entity174 of the femoral neck are described. Femoral heads were obtained from @entity1 who had surgery for the treatment of @entity2249 or total hip replacement for advanced @entity571 . Blocks from the principal compressive region of a coronal slice were sampled systematically to prepare 10 microns sections for automated analysis. There was no significant difference in the mineral bone content of the osteoarthritic (OA) and @entity2249 ( @entity2249 ) cases or between males and females for each group. The regression of mineralized bone on age was significant for OA data, showing a decrease in mineralized bone volume with age, whereas there was no significant relationship for the @entity2249 data. Surface density was significantly lower in the OA group than in the @entity2249 group despite the fact there is no difference in the mineralized bone. The regression of surface density on age was not statistically significant in both groups, although regression of surface density on the mineralized bone was significant for both groups and demonstrated that OA cases generated less surface than @entity2249 cases for the same amount of mineralized bone volume. The trabeculae in OA were significantly thicker than in @entity2249 , and spacing in OA was significantly greater than in @entity2249 . The regression of trabecular thickness and spacing on age was not significant for either OA or @entity2249 . For OA, thickness and spacing showed a significant regression on the mineralized bone volume, positive and negative, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Histomorphometric changes in the trabecular structure of a selected stress region in the femur in @entity1 with @entity571 and XXXX of the femoral neck.

answer: @entity174 :: (MESH:D050723,Disease) :: ['fracture']


abstract: Histomorphometric changes in the trabecular structure of the principal compressive stress region in the femur in @entity1 with @entity571 and @entity174 of the femoral neck are described. Femoral heads were obtained from @entity1 who had surgery for the treatment of @entity2249 or total hip replacement for advanced @entity571 . Blocks from the principal compressive region of a coronal slice were sampled systematically to prepare 10 microns sections for automated analysis. There was no significant difference in the mineral bone content of the osteoarthritic (OA) and @entity2249 ( @entity2249 ) cases or between males and females for each group. The regression of mineralized bone on age was significant for OA data, showing a decrease in mineralized bone volume with age, whereas there was no significant relationship for the @entity2249 data. Surface density was significantly lower in the OA group than in the @entity2249 group despite the fact there is no difference in the mineralized bone. The regression of surface density on age was not statistically significant in both groups, although regression of surface density on the mineralized bone was significant for both groups and demonstrated that OA cases generated less surface than @entity2249 cases for the same amount of mineralized bone volume. The trabeculae in OA were significantly thicker than in @entity2249 , and spacing in OA was significantly greater than in @entity2249 . The regression of trabecular thickness and spacing on age was not significant for either OA or @entity2249 . For OA, thickness and spacing showed a significant regression on the mineralized bone volume, positive and negative, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

title: Histomorphometric changes in the trabecular structure of a selected stress region in the femur in XXXX with @entity571 and @entity174 of the femoral neck.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND AND OBJECTIVES: Although resection of @entity242 with en bloc nephrectomy confers the potential benefit of improved @entity5 control, little has been published about the long-term post-operative renal function of these @entity1 . METHODS: Retrospective review of 54 @entity1 undergoing nephrectomy for @entity242 was performed. Clinicopathologic and treatment characteristics, pre- and post-operative @entity1011 ( @entity8818 ) values, and estimated glomerular filtration rates (eGFR) were recorded. The primary outcome measure was progression of @entity740 ( @entity740 ) stage. RESULTS: Median preoperative eGFR was 85   ml/min. Post-nephrectomy, median nadir eGFR was 44   ml/min, rebounding to 62   ml/min at median follow-up of 50 months. Of 49 @entity1 with preoperative eGFR >= 60   ml/min ( @entity740 stage 1,2), 51% preserved eGFR >= 60 postoperatively, whereas 49% progressed to @entity740 stage 3 (eGFR 30-59). Independent risk factors for progression of @entity740 stage were age and preoperative eGFR. Eleven @entity1 died of recurrent disease, whereas no @entity1 died of @entity454 ( @entity454 ) or required dialysis. CONCLUSIONS: Although progression of @entity740 stage occurs in nearly one-half of @entity1 followed for more than 4 years after nephrectomy for @entity242 , no @entity1 progressed to @entity454 or had a limitation in systemic therapy options, even with progression to @entity740 stage 3. J. Surg. Oncol. 2015 111:98-102.    2015 Wiley Periodicals, Inc.

title: Post-operative renal function following nephrectomy as part of en bloc resection of XXXX ( @entity242 ).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['locoregional tumor']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['CKD', 'chronic kidney disease']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity454 :: ('MESH:D007676', 'Disease') :: ['ESRD', 'end stage renal disease']

answer: @entity242 :: (MESH:D012509,Disease) :: ['retroperitoneal sarcoma']


abstract: BACKGROUND AND OBJECTIVES: Although resection of @entity242 with en bloc nephrectomy confers the potential benefit of improved @entity5 control, little has been published about the long-term post-operative renal function of these @entity1 . METHODS: Retrospective review of 54 @entity1 undergoing nephrectomy for @entity242 was performed. Clinicopathologic and treatment characteristics, pre- and post-operative @entity1011 ( @entity8818 ) values, and estimated glomerular filtration rates (eGFR) were recorded. The primary outcome measure was progression of @entity740 ( @entity740 ) stage. RESULTS: Median preoperative eGFR was 85   ml/min. Post-nephrectomy, median nadir eGFR was 44   ml/min, rebounding to 62   ml/min at median follow-up of 50 months. Of 49 @entity1 with preoperative eGFR >= 60   ml/min ( @entity740 stage 1,2), 51% preserved eGFR >= 60 postoperatively, whereas 49% progressed to @entity740 stage 3 (eGFR 30-59). Independent risk factors for progression of @entity740 stage were age and preoperative eGFR. Eleven @entity1 died of recurrent disease, whereas no @entity1 died of @entity454 ( @entity454 ) or required dialysis. CONCLUSIONS: Although progression of @entity740 stage occurs in nearly one-half of @entity1 followed for more than 4 years after nephrectomy for @entity242 , no @entity1 progressed to @entity454 or had a limitation in systemic therapy options, even with progression to @entity740 stage 3. J. Surg. Oncol. 2015 111:98-102.    2015 Wiley Periodicals, Inc.

title: Post-operative renal function following nephrectomy as part of en bloc resection of @entity242 ( XXXX ).

answer: @entity242 :: (MESH:D012509,Disease) :: ['RPS']


abstract: OBJECTIVES: This study aims to investigate demographic features, type and localization of foreign bodies, mean hospitalization duration, and peri- and @entity260 ratios of @entity1 with @entity5744 . @entity1 AND METHODS: Seventy @entity1 (23 males, 47 females; mean age 32  14.5 months; range 3 months to 10 years) who were diagnosed with @entity5744 in our clinic between January 2007 and August 2010, and performed rigid bronchoscopy under general anesthesia were included in this study. RESULTS: Main findings were cough, wheezing, and witnessed @entity1173 . No foreign body was detected in 14 @entity1 (20%). Foreign bodies in 56 @entity1 (80%) were successfully removed. Foreign bodies were located in the left bronchial tree in 23 @entity1 (41%), right bronchial tree in 18 @entity1 (32%), @entity825 in four @entity1 (7%), bilateral bronchial tree in three @entity1 (5%), carina in two @entity1 (3%), subglottic region in two @entity1 (3%), pyriform sinus in two @entity1 (2%), laryngeal ventricle in one @entity1 (1.7%), and right vocal cord in one @entity1 (1.7%). Foreign bodies were hard-shelled nuts in 23 @entity1 (41%), beans in 14 @entity1 (25%), plastic materials in 11 @entity1 (19%), and other bodies in eight @entity1 (14%). CONCLUSION: Foreign body @entity1173 is a risky condition particularly for @entity1 under the age of four. Bronchoscopy is still the most commonly used and reliable diagnosis and treatment method. Foreign body @entity1173 should be kept in mind in @entity1 with persistent cough, wheezing, and unilateral pulmonary findings in radiologic imaging.

title: [Foreign body XXXX : an urgent airway condition].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient', 'PATIENTS']

entities_list: @entity5744 :: ('MESH:D005547', 'Disease') :: ['foreign body aspiration']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complication']

entities_list: @entity1173 :: ('MESH:D053120', 'Disease') :: ['aspiration']

answer: @entity1173 :: (MESH:D053120,Disease) :: ['aspiration']


abstract: Concerns remain over the ability to stent across of the lower esophageal sphincter (LES) for @entity420 and the effects of gastroesophageal (GE) reflux. Thus, the aim of this study was to demonstrate minimal quality-of-life (QOL) side effects in @entity1 undergoing esophageal stenting across the LES. An Institutional Review Board-approved prospective clinical trial evaluated the results of the Gastrointestinal Symptom questionnaire that includes a @entity354 ( @entity354 ) assessment ( @entity354 -HRQL) and a @entity1282 assessment. Consecutive @entity1 were enrolled in this clinical trial, with 81 per cent male, 19 per cent female, median age of 62 years, with @entity420 as their diagnosis. The median @entity1282 score was 3 (only liquids can be tolerated) prestent and was improved to a median score of 0 (ability to eat all foods) poststent (P = 0.01). The median @entity354 score was 0 (none) prestent and did not change with a median score of 0 (none) poststent (P = 0.2). All @entity354 -related questions were unchanged prestent and poststent in all categories, specifically: frequency of @entity354 , time of day of reflux, @entity158 behind breastbone, and @entity158 medications. There was also no difference in regurgitation frequency (median prestent 1 vs poststent 0, P = 0.08), texture (prestent 2 [semisolid] vs poststent 1 [liquid]). There was only a statistical change in the ability to belch (prestent 0 [no ability] to poststent 1 [ability]), P = 0.02) and the ability to vomit. Esophageal stenting across the GE junction for @entity1282 relief in @entity5 does not adversely effect a @entity1 's QOL in regard to reflux-related symptoms.

title: Gastroesophageal Reflux Disease-related Symptom Assessment in Subjects with XXXX Receiving Esophageal Stents.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['esophageal malignancies']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['GERD', 'validated GE reflux disease']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['esophageal adenocarcinoma', 'adenocarcinoma of the GE junction']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Malignant Dysphagia']


abstract: OBJECTIVE: The contribution contains a comparison of the history data of adolescent @entity1 hospitalized at the Department of @entity1 Psychiatry, @entity1  s Faculty Hospital in Bratislava with the diagnoses of @entity716 ( @entity716 ), @entity161 ( @entity161 ) and with @entity734 ( @entity734 ). BACKGROUND: @entity716 is rarely recorded and little documented by the age of 18. The etiology of this disorder is still relatively unclear. METHODS: The data collection was carried out from @entity1 hospitalized between January 1, 2001 and December 31, 2012. We recorded data from 20 @entity1 hospitalized with @entity716 , 50 @entity1 hospitalized with @entity161 , and 50 @entity1 hospitalized with @entity734 . We collected and compared the data on family history, perinatal complications, early psychomotor development, data on psychical problems before their hospitalization, and presence of unfavorable life situations in their childhood. CONCLUSION: The data of adolescents with @entity716 are more similar to the data of @entity1 with @entity161 than @entity1 with @entity734 in terms of the burden of family history, the frequency of complications during pregnancy and delivery, and the frequency of the subsequent early @entity1155 . In terms of unfavorable life situations and @entity458 for which they were monitored in a @entity146 ward before their hospitalization with @entity716 , their data are more similar to those of @entity1 with @entity734 than with @entity161 (Tab. 3, Fig. 1, Ref. 21). KEYWORDS: adolescent, @entity734 , psychoactive drugs, substance-induced @entity716 , early onset @entity161 .

title: Comparison of history of adolescents with substance-induced @entity716 , early onset XXXX and @entity734 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Child', 'patients', 'Children']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological problems']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'EOS', 'Early Onset Schizophrenia']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['SIP', 'psychosis', 'Substance-Induced Psychosis']

entities_list: @entity1155 :: ('MESH:D011596', 'Disease') :: ['psychomotor impairment']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['Substance Use Disorders', 'substance-related disorders', 'SUD']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: OBJECTIVE: The contribution contains a comparison of the history data of adolescent @entity1 hospitalized at the Department of @entity1 Psychiatry, @entity1  s Faculty Hospital in Bratislava with the diagnoses of @entity716 ( @entity716 ), @entity161 ( @entity161 ) and with @entity734 ( @entity734 ). BACKGROUND: @entity716 is rarely recorded and little documented by the age of 18. The etiology of this disorder is still relatively unclear. METHODS: The data collection was carried out from @entity1 hospitalized between January 1, 2001 and December 31, 2012. We recorded data from 20 @entity1 hospitalized with @entity716 , 50 @entity1 hospitalized with @entity161 , and 50 @entity1 hospitalized with @entity734 . We collected and compared the data on family history, perinatal complications, early psychomotor development, data on psychical problems before their hospitalization, and presence of unfavorable life situations in their childhood. CONCLUSION: The data of adolescents with @entity716 are more similar to the data of @entity1 with @entity161 than @entity1 with @entity734 in terms of the burden of family history, the frequency of complications during pregnancy and delivery, and the frequency of the subsequent early @entity1155 . In terms of unfavorable life situations and @entity458 for which they were monitored in a @entity146 ward before their hospitalization with @entity716 , their data are more similar to those of @entity1 with @entity734 than with @entity161 (Tab. 3, Fig. 1, Ref. 21). KEYWORDS: adolescent, @entity734 , psychoactive drugs, substance-induced @entity716 , early onset @entity161 .

title: Comparison of history of adolescents with substance-induced XXXX , early onset @entity161 and @entity734 .

answer: @entity716 :: (MESH:D011605,Disease) :: ['psychosis']


abstract: OBJECTIVE: The contribution contains a comparison of the history data of adolescent @entity1 hospitalized at the Department of @entity1 Psychiatry, @entity1  s Faculty Hospital in Bratislava with the diagnoses of @entity716 ( @entity716 ), @entity161 ( @entity161 ) and with @entity734 ( @entity734 ). BACKGROUND: @entity716 is rarely recorded and little documented by the age of 18. The etiology of this disorder is still relatively unclear. METHODS: The data collection was carried out from @entity1 hospitalized between January 1, 2001 and December 31, 2012. We recorded data from 20 @entity1 hospitalized with @entity716 , 50 @entity1 hospitalized with @entity161 , and 50 @entity1 hospitalized with @entity734 . We collected and compared the data on family history, perinatal complications, early psychomotor development, data on psychical problems before their hospitalization, and presence of unfavorable life situations in their childhood. CONCLUSION: The data of adolescents with @entity716 are more similar to the data of @entity1 with @entity161 than @entity1 with @entity734 in terms of the burden of family history, the frequency of complications during pregnancy and delivery, and the frequency of the subsequent early @entity1155 . In terms of unfavorable life situations and @entity458 for which they were monitored in a @entity146 ward before their hospitalization with @entity716 , their data are more similar to those of @entity1 with @entity734 than with @entity161 (Tab. 3, Fig. 1, Ref. 21). KEYWORDS: adolescent, @entity734 , psychoactive drugs, substance-induced @entity716 , early onset @entity161 .

title: Comparison of history of adolescents with substance-induced @entity716 , early onset @entity161 and XXXX .

answer: @entity734 :: (MESH:D019966,Disease) :: ['substance use disorders']


abstract: INTRODUCTION: Recent studies have shown that @entity1 with @entity10931 ( @entity10931 ) experience a @entity308 mood during the episode. However, little evidence has been found of possible mood congruency effects on memory, which are probably masked by the massive anterograde @entity2730 . An implicit assessment could provide a means of settling this question. METHODS: First, we measured @entity1 ' emotional states on psychopathological scales. Second, we administered a lexical decision task to assess three priming effects: Semantic priming (SP; table-chair), emotional priming (EP; murder-garbage), and emotional plus semantic priming (ESP; cemetery-coffin). RESULTS: @entity1 displayed a more depressed mood than controls. For @entity1 , we found a SP effect in the ESP condition and a striking inhibition effect (i.e., negative target recognized more slowly when preceded by a negative prime rather than a neutral one) in the EP condition. For controls, a priming effect was found in the SP and ESP conditions, but not the EP condition. Finally, whereas the priming effect was greater in SP than in the other two conditions for controls, for @entity1 it was the EP condition that stood out from the other two, being the only condition that led to an inhibition effect. CONCLUSIONS: We highlighted a mood congruency effect in @entity10931 which could impel @entity1 to focus their attention on negative information. While the negative valence of items always led to a slowdown in reaction times for both @entity1 and controls, attesting to a negativity bias, this bias was greater in @entity1 , leading to an inhibition effect.

title: Influence of @entity308 in  XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity10931 :: ('MESH:D020236', 'Disease') :: ['transient global amnesia', 'TGA']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive']

answer: @entity10931 :: (MESH:D020236,Disease) :: ['transient global amnesia']


abstract: INTRODUCTION: Recent studies have shown that @entity1 with @entity10931 ( @entity10931 ) experience a @entity308 mood during the episode. However, little evidence has been found of possible mood congruency effects on memory, which are probably masked by the massive anterograde @entity2730 . An implicit assessment could provide a means of settling this question. METHODS: First, we measured @entity1 ' emotional states on psychopathological scales. Second, we administered a lexical decision task to assess three priming effects: Semantic priming (SP; table-chair), emotional priming (EP; murder-garbage), and emotional plus semantic priming (ESP; cemetery-coffin). RESULTS: @entity1 displayed a more depressed mood than controls. For @entity1 , we found a SP effect in the ESP condition and a striking inhibition effect (i.e., negative target recognized more slowly when preceded by a negative prime rather than a neutral one) in the EP condition. For controls, a priming effect was found in the SP and ESP conditions, but not the EP condition. Finally, whereas the priming effect was greater in SP than in the other two conditions for controls, for @entity1 it was the EP condition that stood out from the other two, being the only condition that led to an inhibition effect. CONCLUSIONS: We highlighted a mood congruency effect in @entity10931 which could impel @entity1 to focus their attention on negative information. While the negative valence of items always led to a slowdown in reaction times for both @entity1 and controls, attesting to a negativity bias, this bias was greater in @entity1 , leading to an inhibition effect.

title: Influence of XXXX in  @entity10931 .

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive symptoms on memory']


abstract: INTRODUCTION: Performance status (PS) is the only known clinical predictor of outcome in @entity1 with advanced @entity1149 ( @entity1149 ), although pharmacogenomic markers may also correlate with outcome. The aim of our study was to correlate clinical and pharmacogenomic measures with overall survival. METHODS: This was an IRB approved, retrospective study in which the medical records of 50 @entity1 with advanced @entity1149 from 1998-2008 were reviewed, and gender, race, PS, and chemotherapy regimens were documented. Stromal expression of pharmacogenomic markers ( @entity319 , @entity11833  , pAKT, and @entity983 ) was measured. Clinical factors and pharmacogenomics markers were compared to overall survival using a Cox proportional hazards model. RESULTS: Forty @entity1 received @entity902 -based therapy. Median age was 65 years. Improved PS, female gender, and @entity136 therapy were significantly associated with longer overall survival (P = 0.004, P = 0.04, and P = 0.003, respectively). Age was not associated with survival. Caucasians had better overall survival in comparison to African Americans with median survival of 14.8 months versus 10.4 months (P = 0.1). @entity1 treated with @entity902 -based therapy had better survival of 15 months versus 8 months for non- @entity902 based therapy (P = 0.01). There was no significant association between any of the pharmacogenomics markers and overall survival other than in @entity1 treated with @entity902 , in whom @entity11833 negativity was strongly associated with longer survival (P = 0.007). CONCLUSION: @entity11833 negativity with @entity902 therapy, @entity136 therapy, good PS, and female gender all correlated with improved overall survival in @entity1 with advanced @entity1149 .

title: The use of pharmacogenomics for selection of therapy in XXXX .

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small-cell lung cancer']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small-cell lung cancer']


abstract: BACKGROUND: @entity2621 testis is a rare entity, and there are only few reports on the malignant transformation of a @entity17588 to @entity3557 in the literature. In this report, we describe the @entity5 testis with distant lung @entity3 associated with trisomy 17 and a coexisting @entity7172 in the thyroid. CASE REPORT: A 56-year-old @entity1 presented after a left orchiectomy for an undescended left testicle. Pathologic examination identified a monodermal @entity44 composed of @entity1374 and associated with a 1.7-cm @entity3557 . Further evaluation showed a pulmonary mass on a chest CT scan. Total thyroidectomy revealed a 0.5-mm focus of @entity3557 , and removal of the lung mass confirmed metastatic @entity3557 . Array-comparative genomic hybridization of both @entity5 showed trisomy 17 in the @entity2621 testes and the lung @entity3 . The @entity1 responded well to radioactive @entity1496 ablation and has no evidence of @entity5 3 years later. CONCLUSION: To our knowledge, this is the first case of @entity3557 in @entity2621 testes metastatic to the lung. It highlights the difficulties in treating these @entity1 . Surgery to remove @entity5 foci, followed by radioactive @entity1496 ablation, resulted in an excellent response in our @entity1 . Interestingly, trisomy 17, which has so far been observed only in noninvasive thyroid nodules, was associated with pulmonary @entity3 in our @entity1 .

title: XXXX in @entity2621 testis with malignant transformation in the lung associated with trisomy 17 successfully treated with total thyroidectomy and radioiodine ablation.

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'papillary thyroid cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'man']

entities_list: @entity17588 :: ('MESH:C562472', 'Disease') :: ['testicular teratoma']

entities_list: @entity2621 :: ('MESH:D050031', 'Disease') :: ['Struma', 'struma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumors', 'malignant transformation of struma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity7172 :: ('MESH:C563277', 'Disease') :: ['papillary microcarcinoma']

entities_list: @entity44 :: ('MESH:D013724', 'Disease') :: ['teratoma']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid parenchyma']

answer: @entity3557 :: (MESH:C536915,Disease) :: ['Papillary thyroid cancer']


abstract: BACKGROUND: @entity2621 testis is a rare entity, and there are only few reports on the malignant transformation of a @entity17588 to @entity3557 in the literature. In this report, we describe the @entity5 testis with distant lung @entity3 associated with trisomy 17 and a coexisting @entity7172 in the thyroid. CASE REPORT: A 56-year-old @entity1 presented after a left orchiectomy for an undescended left testicle. Pathologic examination identified a monodermal @entity44 composed of @entity1374 and associated with a 1.7-cm @entity3557 . Further evaluation showed a pulmonary mass on a chest CT scan. Total thyroidectomy revealed a 0.5-mm focus of @entity3557 , and removal of the lung mass confirmed metastatic @entity3557 . Array-comparative genomic hybridization of both @entity5 showed trisomy 17 in the @entity2621 testes and the lung @entity3 . The @entity1 responded well to radioactive @entity1496 ablation and has no evidence of @entity5 3 years later. CONCLUSION: To our knowledge, this is the first case of @entity3557 in @entity2621 testes metastatic to the lung. It highlights the difficulties in treating these @entity1 . Surgery to remove @entity5 foci, followed by radioactive @entity1496 ablation, resulted in an excellent response in our @entity1 . Interestingly, trisomy 17, which has so far been observed only in noninvasive thyroid nodules, was associated with pulmonary @entity3 in our @entity1 .

title: @entity3557 in XXXX testis with malignant transformation in the lung associated with trisomy 17 successfully treated with total thyroidectomy and radioiodine ablation.

answer: @entity2621 :: (MESH:D050031,Disease) :: ['struma']


abstract: Although the association between @entity28 and @entity101 is well-known, the underlying mechanism remains elusive. Previously, we have shown that 3 week fat feeding in @entity95 produces greater visceral adiposity, @entity101 , @entity591 and elevated renal sympathetic nerve activity (RSNA) compared to @entity95 on a normal diet. Because hyperinsulinaemia, hyperleptinemia, and dyslipidaemia are independent cardiovascular risk factors associated with @entity101 we compared plasma @entity8446 , leptin, and lipid profiles in male New Zealand White @entity95 fed a normal fat diet (NFD 4.3% fat, n = 11) or high fat diet (HFD 13.4% fat, n = 13) at days 1, 2, 3 and weeks 1, 2, 3 of the diet. Plasma concentrations of diacylglyceride (DG), triacylglyceride (TG), @entity2367 and @entity8557 (CE) were obtained after analysis by liquid chromatography mass spectrometry. Plasma @entity8446 and @entity413 increased within the first 3 days of the diet in HFD @entity95 (P < 0.05) and remained elevated at week 1 (P < 0.05). Blood pressure and heart rate (HR) followed a similar pattern. By contrast, in both groups, plasma leptin levels remained unchanged during the first few days (P > 0.05), increasing by week 3 in fat fed animals alone (P < 0.05). Concentrations of total DG, TG, CE, and @entity2367 at week 3 did not differ between groups (P > 0.05). Our data show plasma @entity8446 increases rapidly following consumption of a HFD and suggests that it may play a role in the rapid rise of blood pressure. Dyslipidaemia does not appear to contribute to the @entity101 in this animal model.

title: Short term fat feeding rapidly increases plasma XXXX but does not result in dyslipidaemia.

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity2367 :: ('CHEBI:17761', 'Chemical') :: ['ceramide', 'Ceramide']

entities_list: @entity8557 :: ('MESH:D002788', 'Chemical') :: ['cholesteryl esters']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity8446 :: (100009181(Tax:9986),Gene) :: ['insulin']


abstract: BACKGROUND: Delayed onset @entity925 (DOMS) occurs following unaccustomed or intense bouts of exercise. Previous research has demonstrated that that preconditioning with low load exercise or heat relieves @entity925 . However, actively warming up the muscles with exercise may be an effective alternative. OBJECTIVES: This study compared preconditioning effect of light load eccentric exercise and heat using microwave diathermy on markers of @entity121 in collegiate males. @entity1 AND METHODS: Thirty six sedentary collegiate males were randomly assigned into two experimental groups: 10% Eccentric exercise group (10% ECC group) and Microwave diathermy group (MWD group). Both the groups performed 30 repetitions of maximal eccentric exercise (Max-ECC) of the elbow flexors. The 10% ECC group performed light load eccentric exercise (10% ECC), five sets, six repetitions using a dumbbell set at 10% of maximal voluntary isometric contraction strength (MVC), 2 days prior to Max-ECC. The MWD group received heat using microwave diathermy (150 watts, 20 minutes) one day prior to Max-ECC. Changes in MVC, range of motion (ROM), upper arm circumference, soreness, were assessed before and 24-72 hours after whereas serum @entity908 kinase activity and @entity880 dehydrogenase (LDH) activity up to 48 hours following the Max-ECC were compared between groups by a mixed model ANOVA. RESULTS: No significant difference (P > 0.05) were found between the groups for changes in all variables post Max-ECC, except for LDH activity showing significant interaction effect (P = 0.04). CONCLUSIONS: Preconditioning with light load eccentric exercise and heat using microwave diathermy treatment did not differ in their effects on @entity121 markers after Max-ECC. However, with time their effects on LDH activity were found to be different.

title: Effect of preconditioning by light load eccentric exercise versus heat on markers of XXXX in collegiate males.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['muscle soreness']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle damage']

answer: @entity121 :: (MESH:D009135,Disease) :: ['muscle damage']


abstract: This retrospective cohort study of 1,345 male employees with potential for exposure to @entity334 analyzes @entity5 incidence and mortality from 1956 to 1976. Expected numbers based on company and national rates have been computed on @entity1 -years. The analyses consider calendar time, payroll classification, occupation, duration of exposure, severity of exposure, and latency. Overall, 25 cases of @entity5 occurred, with 20.5 expected based on company rates. Of these, eight were @entity5 cases, with 4.4 expected. Excesses were found primarily during the 1970-76 time period among wage roll employees who had worked during plant start-up. A trend toward increased risks was seen with increased duration and severity of exposure. Twenty @entity5 deaths were found, with 17.4 expected according to company rates. Since many @entity5 cases were recently diagnosed and are living, it may be premature to evaluate mortality statistics. These findings, coupled with results from tests in laboratory animals, raise the serious suspicion that @entity334 may be a @entity1 carcinogen.

title: Epidemiologic study of workers exposed to XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['respiratory cancer', 'cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'person']

entities_list: @entity334 :: ('MESH:D000181', 'Chemical') :: ['acrylonitrile']

answer: @entity334 :: (MESH:D000181,Chemical) :: ['acrylonitrile']


abstract: PURPOSE OF THE STUDY The aim of the study is to present the technique of pedicle subtraction osteotomy (PSO) of the seventh cervical vertebra (C7) for correction of @entity2003 of the cervicothoracic junction (C/Th) in @entity1 with severe @entity1691 ( @entity1691 ).. MATERIAL AnD METHODS The PSO technique for correction of @entity2003 of the C/Th spine was used in fie @entity1 with the aim to restore their ability of horizontal vision. The follow-up in all @entity1 lasted two years at least. Clinical assessment of treatment results was based on the @entity1 ' neurological status and their satisfaction with the correction achieved. Improvement in a vertical 2) line of sight was evaluated using the angle measured between the forehead-chin line and the vertical ( @entity21063 angle) in a lateral view photograph of the standing @entity1 . The achieved correction of @entity85 was assessed by comparing the pre-operative Cobb's angle between the second cervical and the fourth thoracic vertebra with the post-operative one. RESULTS The average operative time was 4 hours (range, 3.5 to 5 h). The average @entity190 was 1600 ml (range, 800 to 2100 ml). On the average, the @entity21063 angle was reduced by 45.2   and Cobb's angle was corrected) by 54.6  . All @entity1 were satisfid with the degree of correction achieved and reported alleviation of @entity4048 . none of the @entity1 showed any signifiant loss of @entity16 at two-year follow-up. DISCUSSIOn The theoretical and technical principles of corrective osteotomy at the C7 level performed for @entity2003 of the spine at the C/Th junction are presented in our group of @entity1 . Our results give support to the superiority of instrumented PSO used currently over the previous techniques. In accordance with the relevant literature data, attention is drawn to a relatively higher risk of this procedure in comparison with corrective surgery performed at the other spinal levels. COnCLUSIOnS Corrective osteotomy of a @entity2003 at the C/Th spine level in @entity1691 @entity1 involves a complex reconstructive surgical procedure. The PSO technique reduces the risk of injury to the visceral structures ventral to the spine, and provides optimal conditions for bone healing at the site of vertebral body resection. If the @entity1 heals well, a successful PSO procedure will markedly improve the quality of his/her life. Key words: corrective osteotomy, cervicothoracic, kyphosis, @entity1691 .

title: [Correction of @entity85 of the cervical spine in XXXX using pedicle subtraction osteotomy of the seventh cervical vertebra].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigid deformity', 'rigid kyphotic deformity']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['correction or neurological deterioration']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['ankylosing spondylitis', 'AS']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['kyphotic deformity']

answer: @entity1691 :: (MESH:D013167,Disease) :: ['ankylosing spondylitis']


abstract: PURPOSE OF THE STUDY The aim of the study is to present the technique of pedicle subtraction osteotomy (PSO) of the seventh cervical vertebra (C7) for correction of @entity2003 of the cervicothoracic junction (C/Th) in @entity1 with severe @entity1691 ( @entity1691 ).. MATERIAL AnD METHODS The PSO technique for correction of @entity2003 of the C/Th spine was used in fie @entity1 with the aim to restore their ability of horizontal vision. The follow-up in all @entity1 lasted two years at least. Clinical assessment of treatment results was based on the @entity1 ' neurological status and their satisfaction with the correction achieved. Improvement in a vertical 2) line of sight was evaluated using the angle measured between the forehead-chin line and the vertical ( @entity21063 angle) in a lateral view photograph of the standing @entity1 . The achieved correction of @entity85 was assessed by comparing the pre-operative Cobb's angle between the second cervical and the fourth thoracic vertebra with the post-operative one. RESULTS The average operative time was 4 hours (range, 3.5 to 5 h). The average @entity190 was 1600 ml (range, 800 to 2100 ml). On the average, the @entity21063 angle was reduced by 45.2   and Cobb's angle was corrected) by 54.6  . All @entity1 were satisfid with the degree of correction achieved and reported alleviation of @entity4048 . none of the @entity1 showed any signifiant loss of @entity16 at two-year follow-up. DISCUSSIOn The theoretical and technical principles of corrective osteotomy at the C7 level performed for @entity2003 of the spine at the C/Th junction are presented in our group of @entity1 . Our results give support to the superiority of instrumented PSO used currently over the previous techniques. In accordance with the relevant literature data, attention is drawn to a relatively higher risk of this procedure in comparison with corrective surgery performed at the other spinal levels. COnCLUSIOnS Corrective osteotomy of a @entity2003 at the C/Th spine level in @entity1691 @entity1 involves a complex reconstructive surgical procedure. The PSO technique reduces the risk of injury to the visceral structures ventral to the spine, and provides optimal conditions for bone healing at the site of vertebral body resection. If the @entity1 heals well, a successful PSO procedure will markedly improve the quality of his/her life. Key words: corrective osteotomy, cervicothoracic, kyphosis, @entity1691 .

title: [Correction of XXXX of the cervical spine in @entity1691 using pedicle subtraction osteotomy of the seventh cervical vertebra].

answer: @entity85 :: (MESH:D009140,Disease) :: ['kyphotic deformity']


abstract: Graph theory-based analysis has been widely employed in brain imaging studies, and altered topological properties of brain connectivity have emerged as important features of @entity1032 such as @entity161 . However, most previous studies have focused on graph metrics of stationary brain graphs, ignoring that brain connectivity exhibits fluctuations over time. Here we develop a new framework for accessing dynamic graph properties of time-varying functional brain connectivity in resting-state fMRI data and apply it to healthy controls (HCs) and @entity1 with @entity161 (SZs). Specifically, nodes of brain graphs are defined by @entity2597 ( @entity2597 ) identified by group independent component analysis (ICA). Dynamic graph metrics of the time-varying brain connectivity estimated by the correlation of sliding time-windowed ICA time courses of @entity2597 are calculated. First- and second-level connectivity states are detected based on the correlation of nodal connectivity strength between time-varying brain graphs. Our results indicate that SZs show decreased variance in the dynamic graph metrics. Consistent with prior stationary functional brain connectivity works, graph measures of identified first-level connectivity states show lower values in SZs. In addition, more first-level connectivity states are disassociated with the second-level connectivity state which resembles the stationary connectivity pattern computed by the entire scan. Collectively, the findings provide new evidence about altered dynamic brain graphs in @entity161 , which may underscore the abnormal brain performance in this @entity1032 .

title: Assessing dynamic brain graphs of time-varying connectivity in fMRI data: application to healthy controls and @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental illness', 'mental diseases']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity2597 :: ('MESH:D003240', 'Disease') :: ['ICNs', 'intrinsic connectivity networks']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: Graph theory-based analysis has been widely employed in brain imaging studies, and altered topological properties of brain connectivity have emerged as important features of @entity1032 such as @entity161 . However, most previous studies have focused on graph metrics of stationary brain graphs, ignoring that brain connectivity exhibits fluctuations over time. Here we develop a new framework for accessing dynamic graph properties of time-varying functional brain connectivity in resting-state fMRI data and apply it to healthy controls (HCs) and @entity1 with @entity161 (SZs). Specifically, nodes of brain graphs are defined by @entity2597 ( @entity2597 ) identified by group independent component analysis (ICA). Dynamic graph metrics of the time-varying brain connectivity estimated by the correlation of sliding time-windowed ICA time courses of @entity2597 are calculated. First- and second-level connectivity states are detected based on the correlation of nodal connectivity strength between time-varying brain graphs. Our results indicate that SZs show decreased variance in the dynamic graph metrics. Consistent with prior stationary functional brain connectivity works, graph measures of identified first-level connectivity states show lower values in SZs. In addition, more first-level connectivity states are disassociated with the second-level connectivity state which resembles the stationary connectivity pattern computed by the entire scan. Collectively, the findings provide new evidence about altered dynamic brain graphs in @entity161 , which may underscore the abnormal brain performance in this @entity1032 .

title: Assessing dynamic brain graphs of time-varying connectivity in fMRI data: application to healthy controls and XXXX with @entity161 .

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: To report a rare case of painful @entity16 after lateral medullary @entity1188 and probe its underlying pathogenesis on the basis of neuroimaging and electrophysiological study. CASE REPORT: A 45-year-old @entity1 presented acute onset of unsteady gait followed by paroxysmal and @entity10 in the distribution of ophthalmic branch of left trigeminal nerve in 2 days. Neurological examinations showed @entity1183 in the distribution of mandibular branch of left trigeminal nerve and @entity2055 . Muscle powers and deep tendon reflexes were normal. Brain magnetic resonance imaging revealed @entity1188 within the left cerebellum and middle portion of dorsolateral medulla. @entity2850 at the root entry zone of trigeminal nerve was excluded. Painful @entity16 secondary to lateral medullary @entity1188 was diagnosed. Ancillary blink reflex study 3 days after the @entity64 event showed abnormal late responses (R2), either ipsilateral or contralateral, after stimulation of left supraorbital nerve, suggesting left medullary lesion. Followup study 3 weeks later demonstrated normalization in absolute latencies of bilateral late responses, in line with remission of @entity158 paroxysms on low-dose @entity2682 treatment. CONCLUSION: Painful @entity16 attributed to lateral medullary @entity1188 is a unique disease entity. Ophthalmic branch involvement, coexisting @entity51 , absence of triggers, and rapid evolvement and remission are its characteristics. Our neuroimaging study delineated @entity385 pathology within descending tract and spinal nucleus of trigeminal nerve. Serial electrophysiological studies provide evidences supporting ephaptic transmission as the main pathogenesis concordant with dynamics of @entity9 and therapeutic implications.

title: A Rare Case of Painful XXXX Secondary to Lateral Medullary Infarct: Neuroimaging and Electrophysiological Studies.

entities_list: @entity1183 :: ('MESH:D006987', 'Disease') :: ['hypoesthesia']

entities_list: @entity2682 :: ('MESH:C040029', 'Chemical') :: ['gabapentin']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['trigeminal neuropathy']

entities_list: @entity2850 :: ('MESH:D009408', 'Disease') :: ['Vascular compression']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['sensory deficits']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['electric shock-like headache']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']

entities_list: @entity2055 :: ('MESH:D001259', 'Disease') :: ['left appendicular ataxia']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity16 :: (MESH:D009422,Disease) :: ['Trigeminal Neuropathy']


abstract: BACKGROUND: In @entity513 in situ of the breast (DCIS), histologic diagnosis obtained before the definitive treatment is related to the risk of underestimation if the presence of @entity3 is found postoperatively. These @entity1 need a second operation to assess the nodal status. We evaluated the upstaging rate in @entity1 with mass-forming DCIS. METHODS: Sixty-three @entity1 with pure DCIS presenting as sonographic mass lesion underwent vacuum-assisted or core-needle biopsy and subsequent surgery. Rates of postoperative upstaging to @entity3 were calculated and compared with clinical character and size of DCIS. RESULTS: Median age of @entity1 (range) was 63  years (27-88) while median diameter of DCIS was 11  mm (6-60). Fifty-six percent of DCIS were upstaged. @entity1 age did not differ significantly between groups with and without final invasion (median, mean, SD): 63, 61.4, 12.5 vs 62, 61.2, 10.6  years, respectively (P   =   0.659). The difference of DCIS size between these groups was statistically important (median, mean, SD): 13, 17.3, 11.4 vs 9.5, 9.8, 3.2  mm, respectively (P   =   0.0003). Mass size and palpability were significant risk factors (P   <   0.001 and P   <   0.01, respectively). Rate of underestimation for mass with diameter  <=10  mm, 10-20  mm and >20  mm was 37, 64 and 91  %, respectively. CONCLUSIONS: DCIS diagnosed on minimal-invasive biopsy of even small sonographic mass is of high risk for the upstaging to @entity3 after final surgical excision. In these @entity1 , subsequent intervention is needed for nodal status assessment. They are good candidates for the sentinel node biopsy during the breast operation to avoid multi-step surgery.

title: Preoperatively diagnosed ductal cancers in situ of the breast presenting as even small masses are of high risk for the XXXX foci in postoperative specimen.

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['ductal carcinoma']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Patient']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['invasive cancer']

answer: @entity3 :: (MESH:D009362,Disease) :: ['invasive cancer']


abstract: The relationship between cell swelling and plasma membrane disruption has been evaluated in thin @entity296 incubated in oxygenated or anoxic Krebs-Ringer phosphate media. Electron microscopy and measurements of inulin-diffusible space were used to monitor plasma membrane integrity. Inulin is excluded from the intracellular space of intact cells; therefore, an increase in tissue inulin content is an excellent marker of loss of plasma membrane integrity. Cell volume was increased during exposure of aerobic slices to @entity2421 media, but the inulin-diffusible space was not increased and electron micrographs showed no detectable plasma membrane alterations. Likewise, during @entity1162 , no evidence of plasma membrane damage was observed. Incubation in anoxic @entity2421 media for 60 minutes resulted in a larger increase in cell volume than under aerobic conditions, but plasma membrane integrity was maintained. @entity2421 (300 minutes) produced no further change in tissue water, but the inulin-diffusible space was increased and electron micrographs revealed breaks in the plasma membranes primarily in association with large subsarcolemmal blebs. Likewise, @entity296 incubated in isotonic anoxic media for 240 minutes and @entity2421 anoxic media for 60 minutes had an increased inulin-diffusible space and the ultrastructural appearance was similar. This ultrastructural appearance is indistinguishable from that observed in myocytes lethally injured by @entity63 . Measurements of tissue osmolarity during total @entity63 showed that osmotically induced cell swelling could occur in @entity63 prior to the onset of plasma membrane disruption. Our results indicate that cell swelling per se is incapable of rupturing plasma membranes; however, after prolonged periods of @entity7493 , the plasma membrane or its cytoskeletal scaffold become injured, which allows the membrane to rupture if the cell is swollen, as might occur during @entity63 or reperfusion.

title: Volume regulation and plasma membrane injury in aerobic, anaerobic, and XXXX in vitro. Effects of osmotic cell swelling on plasma membrane integrity.

entities_list: @entity7493 :: ('MESH:D011502', 'Disease') :: ['energy deficiency']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial slices']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic myocardium', 'ischemia']

entities_list: @entity2421 :: ('MESH:D009123', 'Disease') :: ['Extended anoxic hypotonic incubation', 'hypotonic']

entities_list: @entity1162 :: ('MESH:D008133', 'Disease') :: ['prolonged anoxic isotonic incubation']

answer: @entity63 :: (MESH:D007511,Disease) :: ['ischemic myocardium']


abstract: BACKGROUND: Tympanometry and pneumatic otoscopy are recommended for diagnosis of @entity2346 media, but are not frequently used by general practitioners (GPs). We examined how, after targeted short training, GP diagnosis and management of @entity2169 was changed by the addition of these techniques to non-pneumatic otoscopy. We further explored factors influencing the uptake of these techniques. METHODS: Between 2011 and 2012, we used a crossover experimental design to determine associations between tympanometry and pneumatic otoscopy and the GP diagnosis and management of @entity2169 in @entity1 aged 6  months to 6  years. GPs recorded a diagnosis and management plan after examining ears using non-pneumatic otoscopy, and another after using either tympanometry or pneumatic otoscopy. We compared diagnosis, prescription of oral antibiotics and planned GP follow-up at these two steps between the tympanometry and pneumatic otoscopy groups. We interviewed @entity1 about their views regarding these techniques and analysed these data thematically. RESULTS: Thirteen GPs recorded 694 ear examinations on 347 @entity1 : 347 examinations with non-pneumatic otoscopy; then 196 using tympanometry; and 151 using pneumatic otoscopy. Tympanometry was more likely to be associated with changes in diagnosis (   (2)   =   28.64, df 1, p   <   0.001) and planned GP follow-up (   (2)   =   9.24, df 1, p   <   0.01) than pneumatic otoscopy. Change in oral antibiotic prescription was no different between the two techniques. GPs preferred tympanometry to pneumatic otoscopy, but cost was a barrier to ongoing use. Pneumatic otoscopy was considered the more difficult skill. GPs were not convinced that the increased detection of @entity2171 afforded by tympanometry and pneumatic otoscopy resulted in benefit to general practice @entity1 . CONCLUSION: Tympanometry was more likely than pneumatic otoscopy to change GP diagnoses and follow-up plans of @entity2169 . Tympanometry may require less training than pneumatic otoscopy. GPs preferred tympanometry due to ease of use and interpretation; however, perceived high cost inhibited their intent to use it in the future. Training, cost and perceived lack of @entity1 benefit are barriers to the use of tympanometry and pneumatic otoscopy in general practice.

title: The effect and acceptability of tympanometry and pneumatic otoscopy in general practitioner diagnosis and management of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'children', 'patients', 'patient']

entities_list: @entity2169 :: ('MESH:D004427', 'Disease') :: ['childhood ear disease', 'ear disease']

entities_list: @entity2171 :: ('MESH:D010034', 'Disease') :: ['middle ear effusion']

answer: @entity2169 :: (MESH:D004427,Disease) :: ['childhood ear disease']


abstract: AIM: This study evaluated the use of polymerase chain reaction for @entity1330 diagnosis in clinical samples. MATERIALS AND METHODS: The sensitivity and specificity of the methodology were evaluated using eight @entity1327 / @entity14851 species complex reference strains and 165 cerebrospinal fluid samples from @entity1 with @entity16 divided into two groups: 96 @entity1 with @entity1330 and @entity791 ; and 69 @entity1 with other @entity16 ( @entity18204 / @entity791 ). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a specific product for @entity1327 and another for @entity14851 ). RESULTS: CN4-CN5 primer set was positive in all @entity1327 standard strains and in 94.8% in DNA samples from @entity1330 and @entity791 group. With the multiplex, no 448-bp product of @entity14851 was observed in the clinical samples of either group. The 695bp products of @entity1327 were observed only in 64.6% of the @entity1330 and @entity791 group. This primer set was negative for two standard strains. The specificity based on the negative samples from the CTL/ @entity791 group was 98.5% in both primer sets. CONCLUSIONS: These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of @entity1327 / @entity14851 species complex in cerebrospinal fluid samples from @entity1 with clinical suspicion of @entity1330 .

title: Molecular diagnosis of @entity1330 in cerebrospinal fluid: comparison of primer sets for @entity1327 and XXXX species complex.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1330 :: ('MESH:D016919', 'Disease') :: ['cryptococcal meningitis']

entities_list: @entity1327 :: ('5207', 'Species') :: ['Cryptococcus', 'C. neoformans', 'Cryptococcus neoformans']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological opportunistic diseases', 'neurological diseases']

answer: @entity14851 :: (552467,Species) :: ['Cryptococcus gattii']


abstract: AIM: This study evaluated the use of polymerase chain reaction for @entity1330 diagnosis in clinical samples. MATERIALS AND METHODS: The sensitivity and specificity of the methodology were evaluated using eight @entity1327 / @entity14851 species complex reference strains and 165 cerebrospinal fluid samples from @entity1 with @entity16 divided into two groups: 96 @entity1 with @entity1330 and @entity791 ; and 69 @entity1 with other @entity16 ( @entity18204 / @entity791 ). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a specific product for @entity1327 and another for @entity14851 ). RESULTS: CN4-CN5 primer set was positive in all @entity1327 standard strains and in 94.8% in DNA samples from @entity1330 and @entity791 group. With the multiplex, no 448-bp product of @entity14851 was observed in the clinical samples of either group. The 695bp products of @entity1327 were observed only in 64.6% of the @entity1330 and @entity791 group. This primer set was negative for two standard strains. The specificity based on the negative samples from the CTL/ @entity791 group was 98.5% in both primer sets. CONCLUSIONS: These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of @entity1327 / @entity14851 species complex in cerebrospinal fluid samples from @entity1 with clinical suspicion of @entity1330 .

title: Molecular diagnosis of @entity1330 in cerebrospinal fluid: comparison of primer sets for XXXX and @entity14851 species complex.

answer: @entity1327 :: (5207,Species) :: ['Cryptococcus neoformans']


abstract: AIM: This study evaluated the use of polymerase chain reaction for @entity1330 diagnosis in clinical samples. MATERIALS AND METHODS: The sensitivity and specificity of the methodology were evaluated using eight @entity1327 / @entity14851 species complex reference strains and 165 cerebrospinal fluid samples from @entity1 with @entity16 divided into two groups: 96 @entity1 with @entity1330 and @entity791 ; and 69 @entity1 with other @entity16 ( @entity18204 / @entity791 ). Two primer sets were tested (CN4-CN5 and the multiplex CNa70S-CNa70A/CNb49S-CNb-49A that amplify a specific product for @entity1327 and another for @entity14851 ). RESULTS: CN4-CN5 primer set was positive in all @entity1327 standard strains and in 94.8% in DNA samples from @entity1330 and @entity791 group. With the multiplex, no 448-bp product of @entity14851 was observed in the clinical samples of either group. The 695bp products of @entity1327 were observed only in 64.6% of the @entity1330 and @entity791 group. This primer set was negative for two standard strains. The specificity based on the negative samples from the CTL/ @entity791 group was 98.5% in both primer sets. CONCLUSIONS: These data suggest that the CN4/CN5 primer set was highly sensitive for the identification of @entity1327 / @entity14851 species complex in cerebrospinal fluid samples from @entity1 with clinical suspicion of @entity1330 .

title: Molecular diagnosis of XXXX in cerebrospinal fluid: comparison of primer sets for @entity1327 and @entity14851 species complex.

answer: @entity1330 :: (MESH:D016919,Disease) :: ['cryptococcal meningitis']


abstract: Total @entity165 level was measured in 8,303 @entity1 and youth in Tokyo. Age ranged from 6 to 18 years. The change of total @entity165 level relates to sex and age, and @entity1 showed higher level than @entity1 . Not a small number of @entity1 revealed elevated total @entity165 level but some @entity1 showed very low level. HDL- @entity165 was determined and prevalence of @entity63 @entity301 risk factors was studied. The elevation of total @entity165 level in senior high school students was caused by either increase of HDL- @entity165 or increased total minus HDL- @entity165 fraction. High school @entity1 with @entity28 were found to have higher serum total @entity165 level accompanied by low HDL- @entity165 level. High school @entity1 of parents with @entity583 were found to have higher total @entity165 level. Majority of Japanese senior high school students were found to have one or more @entity301 risk factors. The necessity of prevention for @entity63 @entity301 starting from childhood in Japan is emphasized.

title: Risk factors of arteriosclerosis in Japanese XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'girls', 'boys']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: Asynchronous flowering of @entity4335 (canola) leads to seeds and siliques at varying stages of maturity as harvest approaches. This range of maturation can result in premature silique dehiscence (pod shattering), resulting in yield losses, which may be worsened by environmental stresses. Therefore, a goal for canola crop improvement is to reduce shattering in order to maximize yield. We performed a comprehensive transcriptome analysis on the dehiscence zone (DZ) and valve of @entity958 and Brassica siliques in shatter resistant and sensitive genotypes at several developmental stages. Among known @entity958 dehiscence genes, we confirmed that homologs of @entity71796 , @entity29399 , @entity71797 , @entity71798 and IND were associated with shattering in @entity13344 and @entity4335 . We noted a correlation between reduced pectin degradation genes and shatter-resistance. Tension between lignified and non-lignified cells in the silique DZ plays a major role in dehiscence. Light microscopy revealed a smaller non-lignified separation layer in relatively shatter-resistant @entity13344 relative to @entity4335 and this corresponded to increased expression of peroxidases involved in @entity39121 polymerization. Sustained repression of auxin biosynthesis, transport and signaling in @entity13344 relative to @entity4335 may cause differences in dehiscence zone structure and cell wall constituents. Tension on the dehiscence zone is a consequence of shrinkage and loss of flexibility in the valves, which is caused by senescence and desiccation. Reduced shattering was generally associated with upregulation of ABA signaling and down-regulation of @entity1786 and @entity7214 signaling, corresponding to more pronounced stress responses and reduced senescence and photosynthesis. Overall, we identified 124 cell wall related genes and 103 transcription factors potentially involved in silique dehiscence.

title: A comprehensive transcriptome analysis of silique development and dehiscence in XXXX and Brassica integrating genotypic, interspecies and developmental comparisons.

entities_list: @entity7214 :: ('MESH:C011006', 'Chemical') :: ['jasmonate']

entities_list: @entity4335 :: ('3708', 'Species') :: ['B. napus', 'Brassica napus']

entities_list: @entity1786 :: ('MESH:C036216', 'Chemical') :: ['ethylene']

entities_list: @entity958 :: ('3702', 'Species') :: ['Arabidopsis']

entities_list: @entity39121 :: ('CHEBI:64477', 'Chemical') :: ['monolignol']

answer: @entity958 :: (3702,Species) :: ['Arabidopsis']


abstract: BACKGROUND: Simultaneous saccharification and fermentation (SSF) is a promising process for bioconversion of lignocellulosic biomass. High glucan loading for hydrolysis and fermentation is an efficient approach to reduce the capital costs for bio-based products production. The SSF of steam-exploded @entity4336 stover (SECS) for @entity1068 production at high glucan loading and high temperature was investigated in this study. RESULTS: Glucan conversion of @entity4336 stover biomass pretreated by steam explosion was maintained at approximately 71 to 79% at an enzyme loading of 30 filter paper units (FPU)/g glucan, and 74 to 82% at an enzyme loading of 60 FPU/g glucan, with glucan loading varying from 3 to 12%. Glucan conversion decreased obviously with glucan loading beyond 15%. The results indicated that the mixture was most efficient in enzymatic hydrolysis of SECS at 3 to 12% glucan loading. The optimal SSF conditions of SECS using a novel @entity375 were inoculation optical density (OD)600   =   4.0, initial pH  4.8, 50% nutrients added, 36  hours pre-hydrolysis time, 39  C, and 12% glucan loading (20% solid loading). With the addition of 2% @entity9266 , glucan conversion, @entity1068 yield, final @entity1068 concentration reached 78.6%, 77.2%, and 59.8  g/L, respectively, under the optimal conditions. The results suggested that the solid and degradation products' inhibitory effect on the hydrolysis and fermentation of SECS were also not obvious at high glucan loading. Additionally, glucan conversion and final @entity1068 concentration in SSF of SECS increased by 13.6% and 18.7%, respectively, compared with separate hydrolysis and fermentation (SHF). CONCLUSIONS: Our research suggested that high glucan loading (6 to 12% glucan loading) and high temperature (39  C) significantly improved the SSF performance of SECS using a thermal- and @entity1068 -tolerant strain of @entity375 due to the removal of degradation products, sugar feedback, and solid's inhibitory effects. Furthermore, the surfactant addition obviously increased @entity1068 yield in SSF process of SECS.

title: Simultaneous saccharification and fermentation of steam-exploded XXXX stover at high glucan loading and high temperature.

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae', 'S. cerevisiae']

answer: @entity4336 :: (381124,Species) :: ['corn']


abstract: BACKGROUND: The MindSpot Clinic (MindSpot) provides remote screening assessments and therapist-guided treatment for @entity148 and @entity308 to adult Australians. Most @entity1 are self-referred. The purpose of this study was to report on the procedures followed to maintain the safety of @entity1 and to examine the circumstances of urgent referrals to local services made by this remote mental health service. METHOD: A description of the procedures used to manage risk, and an audit of case summaries of @entity1 who were urgently referred for crisis intervention. The reported measures were scores on self-report scales of @entity458 ( @entity7434 ) and @entity308 (PHQ-9), the number reporting suicidal thoughts and plans, and the number of acute referrals. RESULTS: A total of 9061 @entity1 completed assessments and consented for analysis of their data in the year from 1 July, 2013 to 30 June, 2014. Of these, 2599 enrolled in online treatment at MindSpot, and the remainder were supported to access local mental health services. Suicidal thoughts were reported by 2366 (26.1  %) and suicidal plans were reported by 213 (2.4  %). There were 51 acute referrals, of whom 19 (37.3  %) lived in regional or remote locations. The main reason for referral was the @entity1 ' self-report of imminent suicidal intent. The police were notified in three cases, and in another case an ambulance attended after the @entity1 reported taking an @entity1445 . For the remaining acute referrals, MindSpot therapists were able to identify a local mental health service or a general practitioner, confirm receipt of a written case summary, and confirm that the @entity1 had been contacted, or that the local service intended to contact the @entity1 . CONCLUSIONS: Around 0.6  % of the @entity1 seeking assessment or treatment by MindSpot were referred to local mental health services for urgent face to face care. The procedures for identifying and managing those @entity1 were satisfactory, and in every case, either emergency services or local mental health services were able to take over the @entity1 's care. This review suggests that the uncertainty associated with taking responsibility for the remote treatment of @entity1 who disclose active suicidal plans is not a major impediment to providing direct access online treatment for severe forms of @entity148 and @entity308 .

title: Procedures for risk management and a review of crisis referrals from the MindSpot Clinic, a national service for the remote assessment and treatment of XXXX and @entity308 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'people']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

answer: @entity148 :: (MESH:D001008,Disease) :: ['anxiety']


abstract: BACKGROUND: The MindSpot Clinic (MindSpot) provides remote screening assessments and therapist-guided treatment for @entity148 and @entity308 to adult Australians. Most @entity1 are self-referred. The purpose of this study was to report on the procedures followed to maintain the safety of @entity1 and to examine the circumstances of urgent referrals to local services made by this remote mental health service. METHOD: A description of the procedures used to manage risk, and an audit of case summaries of @entity1 who were urgently referred for crisis intervention. The reported measures were scores on self-report scales of @entity458 ( @entity7434 ) and @entity308 (PHQ-9), the number reporting suicidal thoughts and plans, and the number of acute referrals. RESULTS: A total of 9061 @entity1 completed assessments and consented for analysis of their data in the year from 1 July, 2013 to 30 June, 2014. Of these, 2599 enrolled in online treatment at MindSpot, and the remainder were supported to access local mental health services. Suicidal thoughts were reported by 2366 (26.1  %) and suicidal plans were reported by 213 (2.4  %). There were 51 acute referrals, of whom 19 (37.3  %) lived in regional or remote locations. The main reason for referral was the @entity1 ' self-report of imminent suicidal intent. The police were notified in three cases, and in another case an ambulance attended after the @entity1 reported taking an @entity1445 . For the remaining acute referrals, MindSpot therapists were able to identify a local mental health service or a general practitioner, confirm receipt of a written case summary, and confirm that the @entity1 had been contacted, or that the local service intended to contact the @entity1 . CONCLUSIONS: Around 0.6  % of the @entity1 seeking assessment or treatment by MindSpot were referred to local mental health services for urgent face to face care. The procedures for identifying and managing those @entity1 were satisfactory, and in every case, either emergency services or local mental health services were able to take over the @entity1 's care. This review suggests that the uncertainty associated with taking responsibility for the remote treatment of @entity1 who disclose active suicidal plans is not a major impediment to providing direct access online treatment for severe forms of @entity148 and @entity308 .

title: Procedures for risk management and a review of crisis referrals from the MindSpot Clinic, a national service for the remote assessment and treatment of @entity148 and XXXX .

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: UNASSIGNED: TIDEL-II was designed to optimise outcomes for newly-diagnosed @entity2212 ( @entity2212 ) @entity1 . Two sequential cohorts enrolled a total of 210 @entity1 , all commencing @entity2213 600 mg/day, with a planned dose escalation to 800mg/day for @entity1 with @entity2213 plasma trough level <1000 ng/mL on day 22 (19%). @entity1 were then assessed with molecular treatment targets: BCR-ABL1  <=10%,  <=1% and  <=0.1% at 3, 6 and 12 months, respectively. Cohort I @entity1 who failed to achieve targets were escalated to @entity2213 800 mg/day (if on 600mg/day), then subsequently switched to @entity10542 400 mg BID for failing the same target 3 months later. Cohort II @entity1 who failed to achieve targets switched to @entity10542 directly, as did @entity1 with intolerance or loss of response in either cohort. At 2 years, 55% of study @entity1 remained on @entity2213 , and 30% were on @entity10542 . Only 12% were >10% BCR-ABL1 at 3 months. Confirmed MMR was achieved in 64% and 73% at 12 and 24 months, respectively. MR(4.5) at 24 months was 34%. Overall and transformation-free survival was 96% and 95% at 3 years, respectively. This trial supports the feasibility and efficacy of an @entity2213 -based approach with selective switching to @entity10542 . Trial Registration #ACTRN12607000325404.

title: TIDEL-II: frontline use of @entity2213 in CML with early switch to XXXX for failure to achieve time-dependent molecular targets.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2212 :: ('MESH:D015466', 'Disease') :: ['chronic phase chronic myeloid leukemia', 'CP-CML']

entities_list: @entity2213 :: ('MESH:C097613', 'Chemical') :: ['imatinib']

entities_list: @entity10542 :: ('MESH:C498826', 'Chemical') :: ['nilotinib']

answer: @entity10542 :: (MESH:C498826,Chemical) :: ['nilotinib']


abstract: UNASSIGNED: TIDEL-II was designed to optimise outcomes for newly-diagnosed @entity2212 ( @entity2212 ) @entity1 . Two sequential cohorts enrolled a total of 210 @entity1 , all commencing @entity2213 600 mg/day, with a planned dose escalation to 800mg/day for @entity1 with @entity2213 plasma trough level <1000 ng/mL on day 22 (19%). @entity1 were then assessed with molecular treatment targets: BCR-ABL1  <=10%,  <=1% and  <=0.1% at 3, 6 and 12 months, respectively. Cohort I @entity1 who failed to achieve targets were escalated to @entity2213 800 mg/day (if on 600mg/day), then subsequently switched to @entity10542 400 mg BID for failing the same target 3 months later. Cohort II @entity1 who failed to achieve targets switched to @entity10542 directly, as did @entity1 with intolerance or loss of response in either cohort. At 2 years, 55% of study @entity1 remained on @entity2213 , and 30% were on @entity10542 . Only 12% were >10% BCR-ABL1 at 3 months. Confirmed MMR was achieved in 64% and 73% at 12 and 24 months, respectively. MR(4.5) at 24 months was 34%. Overall and transformation-free survival was 96% and 95% at 3 years, respectively. This trial supports the feasibility and efficacy of an @entity2213 -based approach with selective switching to @entity10542 . Trial Registration #ACTRN12607000325404.

title: TIDEL-II: frontline use of XXXX in CML with early switch to @entity10542 for failure to achieve time-dependent molecular targets.

answer: @entity2213 :: (MESH:C097613,Chemical) :: ['imatinib']


abstract: BACKGROUND: The conservative treatment of pediatric @entity3330 can be socially and financially burdensome for @entity1 and families due to the long period of immobilization. New operative techniques have consistently gained significance in the treatment of such fractures due to a shorter period of immobilization. Elastic stable intramedullary nailing (ESIN) in particular has been proven to lead to better outcome in comparison to conservative treatment. This article presents the first study that compares the outcome of three versus two ESINs in the treatment of pediatric femoral shaft fractures. MATERIAL AND METHODS: A retrospective analysis of all @entity1 who underwent operative treatment of @entity3330 with ESINs in our hospital from 2009-2012 was carried out. A follow-up examination was performed in mid-2013 by standardized evaluation of @entity3656 and the movement capacity of the hip and knee joint. RESULTS: The follow-up examination revealed a @entity3656 of the injured leg when three ESINs were used (p   =   0.013) and an impairment of the movement capacity in the hip joint of the injured leg (p   =   0.029). In addition the surgery time for metal removal of three ESINs was higher (p   =   0.046). All other evaluated parameters did not show any differences. CONCLUSION: In this study population the treatment of pediatric femoral shaft fractures with three ESINs showed no benefit in comparison to two ESINs and therefore should not be used to treat @entity3330 . The @entity3656 using three ESINs may be explained by a nonsymmetrical distribution of support points leading to an increased micromovement of the bone with increased callus formation.

title: [Therapy of pediatric XXXX : Two versus three elastic stable intramedullary nails.]

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3656 :: ('MESH:D007870', 'Disease') :: ['leg length discrepancy']

entities_list: @entity3330 :: ('MESH:D005264', 'Disease') :: ['femoral fractures']

answer: @entity3330 :: (MESH:D005264,Disease) :: ['femoral fractures']


abstract: UNASSIGNED: In this study, the proximate and @entity844 compositions of the muscle tissue of 186 samples of fish belonging to fifteen species of freshwater fish harvested in subalpine lakes ( @entity22485 , shad, @entity30947 , whitefish, @entity7136 , pike, black bullhead, @entity31094 , perch, Italian roach, roach, rudd, @entity23936 , chub and @entity16885 ) were investigated. Most of the fish demonstrated a lipid content in the fillet lower than 2.0  g 100  g(-1) wet weight (range 0.6-9.7). A strong relationship between feeding behavior and @entity844 composition of the muscle lipids was observed. Planktivorous fish showed the lowest amounts of n-3 @entity1718 (p  <  0.05), but the highest @entity8981 ( @entity8981 ) contents, in particular 18:1n-9. Conversely, carnivorous fish showed the highest amounts of @entity1718 and @entity9539 (p  <  0.05), but the lowest @entity8981 contents. Omnivorous fish showed substantial proportions of n-3 @entity1718 and the highest contents of @entity9540 . Principal component analysis showed a distinct separation between fish species according to their feeding habits and demonstrated that the most contributing trophic markers were 18:1n-9, 18:3n-3, 22:6n-3 and 20:4n-6. The quantitative amounts n-3 @entity5204 in muscle tissues varied depending on the fish species, the lipid content and the feeding habits. Some species were very lean, and therefore would be poor choices for @entity1 consumption to meet dietary n-3 fatty acid requirements. Nevertheless, the more frequently consumed and appreciated fish, shad and whitefish, had @entity8393 and @entity4601 contents in the range 900-1,000  mg 100  g(-1) fresh fillet.

title: XXXX Composition of Freshwater Wild Fish in Subalpine Lakes: A Comparative Study.

entities_list: @entity5204 :: ('CHEBI:26208', 'Chemical') :: ['polyunsaturated fatty acid']

entities_list: @entity844 :: ('CHEBI:35366', 'Chemical') :: ['fatty acid']

entities_list: @entity8981 :: ('CHEBI:25413', 'Chemical') :: ['MUFA', 'monounsaturated fatty acid']

entities_list: @entity9540 :: ('MESH:D043371', 'Chemical') :: ['n-6 fatty acids']

entities_list: @entity9539 :: ('MESH:D015525', 'Chemical') :: ['n-3 fatty acids']

entities_list: @entity1718 :: ('MESH:D005227', 'Chemical') :: ['fatty acids', 'saturated fatty acids']

answer: @entity844 :: (CHEBI:35366,Chemical) :: ['Fatty Acid']


abstract: UNASSIGNED: Applications of @entity3928 ( @entity3928 ) are rapidly expanding and encompass molecular and cellular biology. @entity3928 aids in the analysis of in vivo global molecular alterations, identifying potential biomarkers which may improve diagnosis and treatment of various pathologies. @entity3928 has added new dimensionality to medical research. Pioneering gynecologists now study molecular mechanisms underlying female reproductive pathology with @entity3928 -based tools. Although @entity13374 including @entity46 , @entity1870 , @entity2909 , and @entity3610 ( @entity3610 ) carry low mortality rates, they cause significant physical, mental, and social detriments. Additionally, some benign disorders are unfortunately associated with @entity5 . @entity3928 -based technology can detect malignant changes in formerly benign proteomes and metabolomes with distinct advantages of speed, sensitivity, and specificity. We present the use of @entity3928 in proteomics and metabolomics, and summarize the current understanding of the molecular pathways concerning female reproductive anatomy. Highlight discoveries of novel protein and metabolite biomarkers via @entity3928 -based technology, we underscore the clinical application of these techniques in the diagnosis and management of @entity13374 .    2015 Wiley Periodicals, Inc. Mass Spec Rev 9999: XX-XX, 2015.

title: A mass spectrometric insight into the origins of XXXX .

entities_list: @entity3610 :: ('MESH:D011085', 'Disease') :: ['polycystic ovarian syndrome', 'PCOS']

entities_list: @entity13374 :: ('MESH:D005831', 'Disease') :: ['benign gynecological disorders', 'benign gynecologic disorders']

entities_list: @entity3928 :: ('MESH:C536030', 'Disease') :: ['mass spectrometry', 'MS']

entities_list: @entity1870 :: ('MESH:D062788', 'Disease') :: ['adenomyosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancies']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis']

entities_list: @entity2909 :: ('MESH:D007889', 'Disease') :: ['leiomyoma']

answer: @entity13374 :: (MESH:D005831,Disease) :: ['benign gynecological disorders']


abstract: PURPOSE: This study addressed whether age is prognostic for @entity1349 ( @entity1349 ) or @entity1349 ( @entity1349 ) in @entity1 with metastatic @entity14 (mCRC). @entity1 AND METHODS: A total of 20,023 @entity1 from 24 first-line clinical trials in the ARCAD (Aide et Recherche en Canc  rologie Digestive) database were analyzed. Primary age effects and interactions with age,sex, performance status (PS), and metastatic site were modeled using Cox proportional hazards stratified by treatment arm within study. RESULTS: Of total @entity1 , 3,051 (15%) were age < or =50 years. Age was prognostic for both @entity1349 (P < .001)and @entity1349 (P < .001), with U-shaped risk (i.e., highest risk was evident in youngest and oldest @entity1 ). Relative to @entity1 of middle age, the youngest @entity1 experienced 19% (95% CI, 7% to 33%) increased risk of @entity204 and 22% (95% CI, 10% to 35%) increased risk of progression. The oldest @entity1 experienced 42% (95% CI, 31% to 54%) increased risk of @entity204 and 15% (95% CI, 7% to 24%) increased risk of progression or @entity204 . This relationship was more pronounced in the first year of follow-up. Age remained marginally significant for @entity1349 (P = .08) when adjusted forPS, sex, and presence of liver, lung, or peritoneal metastases, and age was significant in an adjusted model for @entity1349 (P = .005). The age effect did not differ by site of metastatic disease, year of enrollment, type of therapy received, or biomarker mutational status. CONCLUSION: Younger and older age are associated with poorer @entity1349 and @entity1349 among treated @entity1 with mCRC. Younger and older @entity1 may represent higher-risk populations, and additional studies are warranted.

title: Association of age with survival in @entity1 with metastatic XXXX : analysis from the ARCAD Clinical Trials Program.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'PFS', 'overall survival', 'progression-free survival']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: PURPOSE: This study addressed whether age is prognostic for @entity1349 ( @entity1349 ) or @entity1349 ( @entity1349 ) in @entity1 with metastatic @entity14 (mCRC). @entity1 AND METHODS: A total of 20,023 @entity1 from 24 first-line clinical trials in the ARCAD (Aide et Recherche en Canc  rologie Digestive) database were analyzed. Primary age effects and interactions with age,sex, performance status (PS), and metastatic site were modeled using Cox proportional hazards stratified by treatment arm within study. RESULTS: Of total @entity1 , 3,051 (15%) were age < or =50 years. Age was prognostic for both @entity1349 (P < .001)and @entity1349 (P < .001), with U-shaped risk (i.e., highest risk was evident in youngest and oldest @entity1 ). Relative to @entity1 of middle age, the youngest @entity1 experienced 19% (95% CI, 7% to 33%) increased risk of @entity204 and 22% (95% CI, 10% to 35%) increased risk of progression. The oldest @entity1 experienced 42% (95% CI, 31% to 54%) increased risk of @entity204 and 15% (95% CI, 7% to 24%) increased risk of progression or @entity204 . This relationship was more pronounced in the first year of follow-up. Age remained marginally significant for @entity1349 (P = .08) when adjusted forPS, sex, and presence of liver, lung, or peritoneal metastases, and age was significant in an adjusted model for @entity1349 (P = .005). The age effect did not differ by site of metastatic disease, year of enrollment, type of therapy received, or biomarker mutational status. CONCLUSION: Younger and older age are associated with poorer @entity1349 and @entity1349 among treated @entity1 with mCRC. Younger and older @entity1 may represent higher-risk populations, and additional studies are warranted.

title: Association of age with survival in XXXX with metastatic @entity14 : analysis from the ARCAD Clinical Trials Program.

answer: @entity1 :: (9606,Species) :: ['patients']