abstract: PURPOSE: To evaluate the visual outcomes and complications after Artisan iris-claw lens implantation in aphakic @entity1 with insufficient capsular support. METHODS: In this prospective, interventional noncontrolled study, aphakic eyes of consecutive @entity1 >2 years of age with insufficient capsular support who underwent Artisan @entity2790 ( @entity2790 ) implantation between June 2011 and December 2012 were followed for 1 year. @entity1 with anterior chamber depth <3 mm, central endothelial cell density (CECD) <2500 cells/mm  , uncontrolled @entity726 , or @entity1596 were excluded. Best-corrected visual acuity, intraocular pressure (IOP), and CECD were measured at 1, 6, and 12 months postoperatively. RESULTS: A total of 25 aphakic eyes of 18 @entity1 (mean age, 7.86    3.08 years) with insufficient capsular support for a standard posterior chamber @entity2790 were included, 18 eyes with subluxated lens and 7 following @entity130 . The mean preoperative logMAR best-corrected visual acuity for traumatic aphakic @entity1 was 0.95    0.36; for @entity1 with subluxation, 0.7      0.26. Values improved at 1 year to 0.38    0.15 (P < 0.002) and 0.3    0.2 (P < 0.0001), respectively. One year after surgery the CECD (2892.64    441.79 cells/mm  ) was significantly reduced from the preoperative and 1 month postoperative values (3573.36    468.9 cells/mm(2), 3081    495 cells/mm  ; P < 0.0001, P < 0.02 resp.). Two cases (8%) developed @entity130 . @entity616 occurred in 1 case (4%). CONCLUSIONS: Artisan @entity2790 implantation for pediatric @entity4118 achieved a good visual outcome.

title: Evaluation of Artisan aphakic XXXX in cases of pediatric @entity4118 with insufficient capsular support.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['Pupillary block']

entities_list: @entity2790 :: ('MESH:D009798', 'Disease') :: ['IOL', 'intraocular lens']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['traumatic dislocation', 'trauma']

answer: @entity2790 :: (MESH:D009798,Disease) :: ['intraocular lens']


abstract: PURPOSE: To evaluate the visual outcomes and complications after Artisan iris-claw lens implantation in aphakic @entity1 with insufficient capsular support. METHODS: In this prospective, interventional noncontrolled study, aphakic eyes of consecutive @entity1 >2 years of age with insufficient capsular support who underwent Artisan @entity2790 ( @entity2790 ) implantation between June 2011 and December 2012 were followed for 1 year. @entity1 with anterior chamber depth <3 mm, central endothelial cell density (CECD) <2500 cells/mm  , uncontrolled @entity726 , or @entity1596 were excluded. Best-corrected visual acuity, intraocular pressure (IOP), and CECD were measured at 1, 6, and 12 months postoperatively. RESULTS: A total of 25 aphakic eyes of 18 @entity1 (mean age, 7.86    3.08 years) with insufficient capsular support for a standard posterior chamber @entity2790 were included, 18 eyes with subluxated lens and 7 following @entity130 . The mean preoperative logMAR best-corrected visual acuity for traumatic aphakic @entity1 was 0.95    0.36; for @entity1 with subluxation, 0.7      0.26. Values improved at 1 year to 0.38    0.15 (P < 0.002) and 0.3    0.2 (P < 0.0001), respectively. One year after surgery the CECD (2892.64    441.79 cells/mm  ) was significantly reduced from the preoperative and 1 month postoperative values (3573.36    468.9 cells/mm(2), 3081    495 cells/mm  ; P < 0.0001, P < 0.02 resp.). Two cases (8%) developed @entity130 . @entity616 occurred in 1 case (4%). CONCLUSIONS: Artisan @entity2790 implantation for pediatric @entity4118 achieved a good visual outcome.

title: Evaluation of Artisan aphakic @entity2790 in cases of pediatric XXXX with insufficient capsular support.

answer: @entity4118 :: (MESH:D001035,Disease) :: ['aphakia']


abstract: @entity70669 is a rare disorder characterised by a combination of anatomic anomalies, and @entity1032 due to a monosomy or trisomy 6q. So far only 12 suspected cases of monosomies 6q have been reported. @entity393 does not seem to be characteristic for this syndrome. We present the case of a @entity1 with @entity70670 . A bilateral severe @entity393 was confirmed by subjective and objective audiometry at the age of 12 years. The @entity1 was successfully equipped with hearing aids. Other features of the syndrome, i.e. @entity1032 , @entity4242 , asymmetric face, broad nasal bridge, @entity5766 , epicanthus, strabism, @entity6127 , @entity1757 and @entity410 were seen. Additionally, a tetraplegy and diaphragmal @entity547 had been diagnosed. The @entity1 was equipped with a @entity5274 because of @entity17304 . In the literature, the possibility of @entity2167 in monosomy 6q is rarely mentioned, although limited verbal speech skills have been reported. A syndromic character of @entity2167 in @entity70669 cannot be excluded. We advise detailed and early audiological testing of @entity1 with monosomy 6q.

title: Severe XXXX in @entity70669 .

entities_list: @entity1 :: ('9606', 'Species') :: ['girl', 'children']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation', 'mental and motor retardation']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity2167 :: ('MESH:D006311', 'Disease') :: ['hearing disorders']

entities_list: @entity1757 :: ('MESH:D006345', 'Disease') :: ['ventricular septum defect']

entities_list: @entity70670 :: ('MESH:C537807', 'Disease') :: ['partial monosomy 6q']

entities_list: @entity5274 :: ('MESH:D005184', 'Disease') :: ['gastrostomy tube']

entities_list: @entity17304 :: ('MESH:D009748', 'Disease') :: ['nutritional disorders']

entities_list: @entity4242 :: ('MESH:D008831', 'Disease') :: ['microcephaly']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['Hearing loss', 'sensory hearing loss']

entities_list: @entity6127 :: ('MESH:D007569', 'Disease') :: ['high arched palate']

entities_list: @entity5766 :: ('MESH:D006972', 'Disease') :: ['hypertelorism']

answer: @entity393 :: (MESH:D034381,Disease) :: ['sensory hearing loss']


abstract: @entity70669 is a rare disorder characterised by a combination of anatomic anomalies, and @entity1032 due to a monosomy or trisomy 6q. So far only 12 suspected cases of monosomies 6q have been reported. @entity393 does not seem to be characteristic for this syndrome. We present the case of a @entity1 with @entity70670 . A bilateral severe @entity393 was confirmed by subjective and objective audiometry at the age of 12 years. The @entity1 was successfully equipped with hearing aids. Other features of the syndrome, i.e. @entity1032 , @entity4242 , asymmetric face, broad nasal bridge, @entity5766 , epicanthus, strabism, @entity6127 , @entity1757 and @entity410 were seen. Additionally, a tetraplegy and diaphragmal @entity547 had been diagnosed. The @entity1 was equipped with a @entity5274 because of @entity17304 . In the literature, the possibility of @entity2167 in monosomy 6q is rarely mentioned, although limited verbal speech skills have been reported. A syndromic character of @entity2167 in @entity70669 cannot be excluded. We advise detailed and early audiological testing of @entity1 with monosomy 6q.

title: Severe @entity393 in XXXX .

answer: @entity70669 :: (MESH:C537810,Disease) :: ['del(6q)-syndrome']


abstract: BACKGROUND/OBJECTIVES: Isolated phytochemicals have been shown to reduce blood pressure; however, combinations of phytochemicals have rarely been tested in @entity1 . We hypothesized that a combination of extracts from grape seed and skin (330   mg), green tea (100   mg), @entity4025 (60   mg) and a blend of @entity3092 , @entity4044 and bilberry (60   mg) would reduce blood pressure (BP) in @entity101 subjects. SUBJECTS/METHODS: Eighteen individuals meeting BP requirements (   130   mm   Hg systolic or    85   mm   Hg diastolic) and criteria for @entity209 were enrolled in a double-blinded, placebo-controlled, crossover trial (ClinicalTrials.gov, NCT01106170). The 28-day placebo and supplement arms were separated by a 2-week washout period, and 14   -h daytime ambulatory BP was assessed at baseline and at the end point of each arm. RESULTS: BP was not altered after placebo. After supplement treatment, diastolic pressure was reduced by 4.4   mm   Hg (P=0.024, 95% CI, 0.6-8.1), systolic pressure was unchanged and mean arterial pressure trended (P=0.052) toward reduction. Serum angiotensin-converting enzyme activity was similar between placebo and supplement arms, but urinary @entity1507 and @entity3542 concentrations were significantly increased (P=0.022) after supplementation. @entity1 aortic endothelial cells treated with metabolites of the @entity6398 used in the @entity1 supplement trial had a significant increase (P=0.005) in insulin-stimulated eNOS phosphorylation and greater (P<0.001) accumulation of @entity3362 / @entity2648 . CONCLUSIONS: Our clinical and in vitro data support the theory that this combination of @entity6398 reduced diastolic pressure by potentiating eNOS activation and @entity842 production. Such supplements may have clinical relevance as stand-alone or adjunct therapy to help reduce BP.

title: A combination of isolated phytochemicals and botanical extracts lowers diastolic blood pressure in a randomized controlled trial of XXXX subjects.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human', 'Human']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity3362 :: ('MESH:D009566', 'Chemical') :: ['nitrates']

entities_list: @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

entities_list: @entity2648 :: ('MESH:D009573', 'Chemical') :: ['nitrites']

entities_list: @entity6398 :: ('MESH:D059808', 'Chemical') :: ['polyphenols']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity4044 :: ('3311', 'Species') :: ['ginkgo biloba']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic syndrome']

entities_list: @entity4025 :: ('MESH:C059514', 'Chemical') :: ['resveratrol']

entities_list: @entity3092 :: ('MESH:D011794', 'Chemical') :: ['quercetin']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertensive']


abstract: BACKGROUND: There is limited knowledge of how co-morbidities influence survival after surgery for @entity5 . This population-based cohort study investigated how Charlson co-morbidity index and specific co-morbidities influenced all-cause and disease-specific mortality. METHODS: Data from all @entity1 who underwent @entity5 surgery in Sweden in 1987-2010, with follow-up until 2012, came from histopathology records, operation charts and nationwide registers. Associations between co-morbidities (Charlson co-morbidity index) and mortality were analysed using Cox proportional hazard regression with adjustment for potential confounding, and presented as hazard ratio (HR) with 95 per cent c.i. RESULTS: Among 1822 @entity1 there were 1474 deaths (80  9 per cent), of which 1139 (77  3 per cent) occurred between 91 days and 5 years after surgery. Overall all-cause mortality was increased in @entity1 with a Charlson score of 2 or more (HR 1  24, 95 per cent c.i. 1  08 to 1  42), and those with a history of @entity583 (HR 1  23, 1  01 to 1  49) or @entity712 (HR 1  31, 1  04 to 1  67). @entity1 with @entity957 had increased overall all-cause mortality if they had been diagnosed with @entity5 (HR 1  36, 1  09 to 1  71), whereas those with @entity420 did not. A Charlson score of 1 or exposure to the co-morbidity groups peripheral @entity455 , @entity358 , connective tissue disease, @entity10189 , @entity409 did not increase mortality. The disease-specific results were generally similar to the all-cause mortality data. CONCLUSION: Co-morbidity with a Charlson score of 2 or more, previous @entity583 and @entity712 were associated with increased mortality after @entity5 surgery undertaken with curative intent.

title: Impact of co-morbidity on mortality after XXXX surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity10189 :: ('MESH:D010437', 'Disease') :: ['peptic ulcer disease']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['congestive heart failure']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['oesophageal cancer', 'cerebrovascular disease (HR 1  35, 1  00 to 1  83) or other cancers']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['diabetes and liver disease']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['chronic pulmonary disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['oesophageal cancer']


abstract: BACKGROUND: @entity419 positron emission tomography (FDG-PET) is valuable in staging of @entity418 . However, FDG-PET may falsely upstage @entity1 leading to incorrect exclusion from surgical treatment. This study was performed to determine the false-positive rate and possible causes. METHODS: The rate of false-positive lesions on FDG-PET was documented in 86 out of a group of 98 @entity1 . Lesions were defined as false positive when pathological examination was negative or as absence of @entity5 activity within 6 months of follow-up. To evaluate the influence of a learning curve on the false-positive rate, the PET scans were revised recently. RESULTS: False-positive lesions were found in 13 @entity1 (13 of 86; 15%). FDG-PET incorrectly revealed only locoregional node metastases in 5 @entity1 in whom surgery with curative intent was performed. Ten lesions in the other 8 @entity1 were classified as distant organ or as nonregional node metastases (M1a/1b). Finally, 5 @entity1 upstaged to M1a/1b underwent a curative resection. The number of false-positive lesions decreased from 16 to 5 (6%) after revision. CONCLUSIONS: Proper interpretation of FDG-PET in staging @entity418 is impeded by false-positive results. Even after completion of the learning curve, positive FDG-PET findings still have to be confirmed by additional investigations.

title: Pitfalls of positive findings in staging XXXX with @entity419 positron emission tomography.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity419 :: ('MESH:D019788', 'Chemical') :: ['18-F-fluorodeoxyglucose']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

answer: @entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']


abstract: BACKGROUND: @entity419 positron emission tomography (FDG-PET) is valuable in staging of @entity418 . However, FDG-PET may falsely upstage @entity1 leading to incorrect exclusion from surgical treatment. This study was performed to determine the false-positive rate and possible causes. METHODS: The rate of false-positive lesions on FDG-PET was documented in 86 out of a group of 98 @entity1 . Lesions were defined as false positive when pathological examination was negative or as absence of @entity5 activity within 6 months of follow-up. To evaluate the influence of a learning curve on the false-positive rate, the PET scans were revised recently. RESULTS: False-positive lesions were found in 13 @entity1 (13 of 86; 15%). FDG-PET incorrectly revealed only locoregional node metastases in 5 @entity1 in whom surgery with curative intent was performed. Ten lesions in the other 8 @entity1 were classified as distant organ or as nonregional node metastases (M1a/1b). Finally, 5 @entity1 upstaged to M1a/1b underwent a curative resection. The number of false-positive lesions decreased from 16 to 5 (6%) after revision. CONCLUSIONS: Proper interpretation of FDG-PET in staging @entity418 is impeded by false-positive results. Even after completion of the learning curve, positive FDG-PET findings still have to be confirmed by additional investigations.

title: Pitfalls of positive findings in staging @entity418 with XXXX positron emission tomography.

answer: @entity419 :: (MESH:D019788,Chemical) :: ['F-18-fluorodeoxyglucose']


abstract: OBJECTIVE: To compare the efficacy of handrubbing with an @entity167 based solution versus conventional handwashing with antiseptic soap in reducing hand contamination during routine @entity1 care. DESIGN: Randomised controlled trial during daily nursing sessions of 2 to 3 hours. SETTING: Three intensive care units in a French university hospital. @entity1 : 23 healthcare workers. INTERVENTIONS: Handrubbing with @entity167 based solution (n=12) or handwashing with antiseptic soap (n=11) when hand hygiene was indicated before and after @entity1 care. Imprints taken of fingertips and palm of dominant hand before and after hand hygiene procedure. Bacterial counts quantified blindly. MAIN OUTCOME MEASURES: Bacterial reduction of hand contamination. RESULTS: With handrubbing the median percentage reduction in bacterial contamination was significantly higher than with handwashing (83% v 58%, P=0.012), with a median difference in the percentage reduction of 26% (95% confidence interval 8% to 44%). The median duration of hand hygiene was 30 seconds in each group. CONCLUSIONS: During routine @entity1 care handrubbing with an @entity167 based solution is significantly more efficient in reducing hand contamination than handwashing with antiseptic soap.

title: Efficacy of handrubbing with XXXX based solution versus standard handwashing with antiseptic soap: randomised clinical trial.

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS', 'patient']

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['alcohol']


abstract: OBJECTIVES: African Americans with @entity1187 receive cardiac catheterization less frequently than whites. The objective was to determine if such disparities extend to acute evaluation and non interventional treatment. METHODS: Data on adults with @entity662 (N = 7,935) presenting to eight emergency departments (EDs) were evaluated from the Internet Tracking Registry of Acute @entity301 . Groups were selected from final ED diagnosis: 1) @entity583 ( @entity583 ), n = 400; 2) unstable @entity951 /non-ST-elevation @entity583 (UA/NSTEMI), n = 1,153; and 3) nonacute coronary syndrome @entity662 (non-ACS @entity2723 ), n = 6,382. American College of Cardiology/American Heart Association guidelines for @entity583 and UA/NSTEMI were used to evaluate racial disparities with logistic regression models. Odds ratios (ORs) were adjusted for age, gender, guideline publication, and insurance status. Non-ACS @entity2723 @entity1 were assessed by comparing electrocardiographic (ECG)/laboratory evaluation, medical treatment, admission rates, and invasive and noninvasive testing for @entity453 ( @entity453 ). RESULTS: African Americans with UA/NSTEMI received glycoprotein IIb/IIIa receptor inhibitors less often than whites (OR, 0.41; 95% CI = 0.19 to 0.91). African Americans with non-ACS @entity2723 underwent ECG/laboratory evaluation, medical treatment, and invasive and noninvasive testing for @entity453 less often than whites (p < 0.05). Other nonwhites with non-ACS @entity2723 were admitted and received invasive testing for @entity453 less often than whites (p < 0.01). African Americans and other nonwhites with @entity583 underwent catheterization less frequently than whites (OR, 0.45; 95% CI = 0.29 to 0.71 and OR, 0.40; 95% CI = 0.17 to 0.92, respectively). A similar disparity in catheterization was noted in UA/NSTEMI therapy (OR, 0.53; 95% CI = 0.40 to 0.68 and OR, 0.68; 95% CI = 0.47 to 0.99). CONCLUSIONS: Racial disparities in acute @entity662 management extend beyond cardiac catheterization. Poor compliance with recommended treatments for ACS may be an explanation.

title: The impact of race on the acute management of XXXX .

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndromes']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['Coronary Syndromes']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['CAD', 'coronary artery disease']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'myocardial infarction', 'acute myocardial infarction']

answer: @entity662 :: (MESH:D002637,Disease) :: ['chest pain']


abstract: OBJECTIVE: To evaluate @entity455 after transpupillary thermotherapy used as the sole treatment for @entity320 . DESIGN: Prospective noncomparative interventional case series. @entity1 : Forty-five eyes of 45 @entity1 affected by malignant @entity320 treated with transpupillary thermotherapy alone with more than 1 year of follow-up. INTERVENTION: Transpupillary thermotherapy was performed through a panfunduscopic contact lens using an 810-nm diode laser. MAIN OUTCOME MEASURES: Dynamic/static @entity941 and @entity3194 angiography were performed at scheduled intervals (24 hours, at 3-month intervals during the first year, and every 6 months thereafter) after transpupillary thermotherapy. Visual acuity, clinical evaluation, fundus photographs, and ultrasonographic examination were also performed. RESULTS: The mean follow-up was 30.5 months (range, 12-54 months). Changes in the choroidal circulation were always confined within the treatment margins (except in one case) and characterized by occlusion of choriocapillaris (100%), patent medium and/or large choroidal vessels (76%), @entity254 (11%), and progressive @entity6980 (42%). Forty-one cases (91%) showed persistent clinical regression, and four cases (9%) recurred; recurrent cases showed @entity254 . CONCLUSIONS: Transpupillary thermotherapy is suggested as a new single therapeutic modality in the treatment of selected @entity320 , but more precise eligibility criteria and longer follow-up are mandatory. Patent choroidal circulation, @entity6980 , and @entity254 after transpupillary thermotherapy might be helpful to detect recurrent @entity5 .

title: Choroidal vascular changes after transpupillary thermotherapy for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['choroidal vascular alterations']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['retinochoroidal anastomosis', 'anastomosis']

entities_list: @entity3194 :: ('MESH:D007208', 'Chemical') :: ['indocyanine green']

entities_list: @entity6980 :: ('MESH:D066253', 'Disease') :: ['choroidal vascular remodeling']

entities_list: @entity941 :: ('MESH:D019793', 'Chemical') :: ['fluorescein']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['choroidal melanoma', 'choroidal melanomas']

answer: @entity320 :: (MESH:D008545,Disease) :: ['choroidal melanoma']


abstract: OBJECTIVE: To analyze the data on @entity1 operated on for @entity1907 ( @entity378 ) with (Group I) or without (Group II) a correct @entity378 diagnosis and preoperative anti- @entity378 treatment. METHODS: Between 1980 and 1997, 144 resections for @entity378 (Groups I+II) were performed. The 80 @entity1 in Group I underwent therapeutic resections: 32 cases involved recurrent @entity6675 or @entity6551 , three involved post- @entity378 bronchiectasis, 13 involved progression of @entity6675 or @entity6551 , and 32 involved persistent @entity6551 after 6 months of anti- @entity378 therapy. The 64 @entity1 in Group II were operated on for a suspicion of @entity5 in 49 cases, for cavitary lesions with haemophthysis in six cases, for @entity75 in seven cases, and for recurrent hydrothorax in two cases. RESULTS: Groups I and II included 0 and five pneumonectomies, 32 and 29 lobectomies, 48 and 20 wedge resections, 0 and nine videothoracoscopic biopsies, and 0 and one hilar lymphadenectomy, respectively. In Groups I and II, the mean duration of postoperative hospitalization was 13.2 and 10.4 days, and the frequency of @entity86 was 11.25 and 4.6%, respectively. The incidence of @entity292 was 1.25 and 0%, the mortality was 0 and 3.1%, and the morbidity was 53.7 and 35.9% in Groups I and II, respectively. Two @entity1 with active disease died in Group II. Pathology demonstrated that the frequency of acid-fast bacilli in Groups I and II was 40 and 25%, respectively. CONCLUSIONS: @entity1 without a correct preoperative @entity378 diagnosis underwent more extensive parenchyma resection. @entity260 increased when acid-fast bacilli were present. The lack of preoperative anti- @entity378 treatment did not involve a higher risk of minor complications, but @entity204 occurred only in this group.

title: Surgical intervention for XXXX : analysis of indications and perioperative data relating to diagnostic and therapeutic resections.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6551 :: ('MESH:D014375', 'Disease') :: ['tuberculomas']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['multiple lesions']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['Postoperative complications']

entities_list: @entity292 :: ('MESH:D005402', 'Disease') :: ['bronchopleural fistula']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative pneumothorax']

entities_list: @entity1907 :: ('MESH:D014397', 'Disease') :: ['pulmonary tuberculosis']

answer: @entity1907 :: (MESH:D014397,Disease) :: ['pulmonary tuberculosis']


abstract: OBJECTIVE: We evaluated the results of surgical treatment postinfarction @entity439 , with preoperative modeling of an optimal left ventricle volume. METHODS: From January 1998 to December 2000, 41 @entity1 underwent left ventricular (LV) @entity439 repair. There were 39 @entity1 and two @entity1 , with a mean age 45.6+/-6.2 years. With echocardiography study, an optimal end-diastolic volume of LV was modeled on the basis of the proper @entity64 index and the contractile ejection fraction (EF). A permissible area of @entity439 resection was calculated by using a difference between the initial and the projected surface area of LV. The patch position and sizes were measured preoperatively. Ventricular reconstruction was performed by using linear plasty in eight @entity1 , septal plasty of the Stoney et al. technique in 14 @entity1 , and endoventriculoplasty of the Dor et al. technique in 19 @entity1 . RESULTS: The mean NYHA functional class decreased from 2.9+/-0.6 to 1.6+/-0.7 postoperatively. The improvement of LV contracting function made itself evident in a decreased end-diastolic volume from 216+/-98 to 158+/-35 ml, and end-systolic volume from 133+/-85 to 80+/-34 ml postoperatively. The mean EF increased from 38+/-11 to 49+/-9% after operation. We noted that preoperative contractile EF corresponded with postoperative EF (49.8+/-11% and 49.3+/-9%, respectively). The projected optimal end-diastolic volume of LV estimated before operation agreed with postoperative data (152+/-33 ml and 158+/-35 ml, respectively). The hospital mortality rate was 7.3%. CONCLUSIONS: Preoperative modeling of an optimal LV volume allows for the estimation of a permissible area of @entity439 resection, the position and sizes of the patch, as well as for the prevention of an excessive reduction of the LV cavity after @entity439 repair.

title: Preoperative modeling of an optimal left ventricle volume for surgical treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['ventricular aneurysms', 'aneurysm']

answer: @entity439 :: (MESH:D000783,Disease) :: ['ventricular aneurysms']


abstract: @entity520 and changes in serum osmolarity are consequences of 0.9% @entity4361 ( @entity4361 ) solution administration. We sought to determine if these physiologic changes influence @entity1 outcome. @entity1 undergoing aortic reconstructive surgery were enrolled and were randomly assigned to receive lactated Ringer's (LR) solution (n = 33) or @entity4361 (n = 33) in a double-blinded fashion. Anesthetic and fluid management were standardized. Multiple measures of outcome were monitored. The @entity4361 @entity1 developed a hyperchloremic @entity520 and received more @entity3157 therapy (30 +/- 62 mL in the @entity4361 group versus 4 +/- 16 mL in the LR group; mean +/- SD), which was given if the base deficit was greater than -5 mEq/L. The @entity4361 @entity1 also received a larger volume of platelet transfusion (478 +/- 302 mL in the @entity4361 group versus 223 +/- 24 mL in the LR group; mean +/- SD). When all blood products were summed, the @entity4361 group received significantly more blood products (P = 0.02). There were no differences in duration of mechanical ventilation, intensive care unit stay, hospital stay, and incidence of complications. When @entity4361 was used as the primary intraoperative solution, significantly more @entity520 was seen on completion of surgery. This @entity520 resulted in no apparent change in outcome but required larger amounts of @entity3157 to achieve predetermined measurements of base deficit and was associated with the use of larger amounts of blood products. These changes should be considered when choosing fluids for surgical procedures involving extensive @entity190 and requiring extensive fluid administration. IMPLICATIONS: Predominant use of 0.9% saline solution in major surgery has little impact on outcome as assessed by duration of mechanical ventilation, intensive care unit stay, hospital stay, and @entity260 , but it does appear to be associated with increased perioperative @entity190 .

title: Normal saline versus lactated Ringer's solution for intraoperative fluid management in XXXX undergoing abdominal aortic aneurysm repair: an outcome study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity3157 :: ('CHEBI:17544', 'Chemical') :: ['bicarbonate']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['postoperative complications']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis', 'Metabolic acidosis']

entities_list: @entity4361 :: ('MESH:C537354', 'Disease') :: ['NS', 'normal saline']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: @entity1 with relapsed @entity1073 have poor prognosis and short survival. Our aim was to determine the efficacy of nonablative allogeneic stem-cell transplantation in @entity1 with relapsed @entity1073 . @entity1 AND METHODS: Eighteen @entity1 were treated in one of two consecutive trials. Thirteen @entity1 underwent a conditioning regimen of @entity3118 (30 mg/m2 daily for 3 days), @entity786 (750 mg/m2 daily for 3 days), and high-dose rituximab. For the remaining five @entity1 , the conditioning regimen consisted of @entity900 (25 mg/m2 daily for 4 days), @entity3118 (30 mg/m2 daily for 2 days), and @entity2592 (1,000 mg/m2 daily for 2 days). @entity1140 and @entity1499 were used for graft-versus-host disease prophylaxis. RESULTS: The median age was 56.5 years. @entity1 underwent a median of three prior chemotherapy regimens. Prior autologous transplantation failed in five (28%) @entity1 and 16 (89%) had chemosensitive disease. Donor cell engraftment occurred in all @entity1 . Eight @entity1 (44%) required no platelet or RBC transfusion, and @entity2132 of greater than grade 2 did not develop in any @entity1 . The day-100 mortality was 0%. Complete remission (CR) occurred in 17 @entity1 . Three @entity1 progressed, and one was reinduced into continuous CR with donor lymphocyte infusion. With a median follow-up period of 26 months, the actuarial probability of current-event-free-survival at 3 years was 82% (95% CI, 65% to 99%). CONCLUSION: Our data suggest that nonablative allogeneic transplantation is a safe and potentially effective strategy for @entity1 with relapsed and chemosensitive @entity1073 .

title: Nonablative allogeneic stem-cell transplantation for advanced/recurrent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine']

entities_list: @entity3118 :: ('MESH:C024352', 'Chemical') :: ['fludarabine']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['acute graft-versus-host disease']

entities_list: @entity1073 :: ('MESH:D020522', 'Disease') :: ['mantle-cell lymphoma']

entities_list: @entity1140 :: ('MESH:D016559', 'Chemical') :: ['Tacrolimus']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

answer: @entity1073 :: (MESH:D020522,Disease) :: ['mantle-cell lymphoma']


abstract: @entity70671 (CST) is a sleep-modulating peptide found exclusively in the brain. Although CST is closely related to @entity1943 (SST) and binds to SST receptors, CST has effects on sleep and neuronal activity in cortex and hippocampus that differ from SST. To uncover the cellular mechanisms affected by CST, we studied the electrophysiological postsynaptic effects of CST and assessed its interaction with SST on hippocampal @entity1399 pyramidal neurons. CST altered intrinsic membrane properties and occluded SST effects, indicating that both peptides similarly augment the sustained K+ M- and leak-currents (IM and IK(L)). In the presence of SST, however, CST elicited an additional inwardly rectifying component in the hyperpolarized range. This effect was unaffected by @entity9666 , used to block K+ currents, but was completely prevented by the selective h-current (Ih) blocker @entity22724 . CST, but not SST, selectively increased Ih in a concentration-dependent manner by augmenting its maximum conductance. CST did not shift the Ih activation curve, and the peptide effect was unaffected by a membrane-permeable analog of @entity268 . We conclude that CST and SST similarly increase K+ conductances in hippocampal neurons, most likely by activating SST receptors. However, CST additionally augments Ih, a voltage-dependent current that plays a key role in the modulation of synaptic integration and regulates oscillatory activity. Our results indicate that CST targets a specific conductance unaffected by SST to modulate cellular mechanisms implicated in sleep regulation.

title: The sleep-modulating peptide XXXX augments the h-current in hippocampal neurons.

entities_list: @entity70671 :: ('MESH:C099323', 'Chemical') :: ['Cortistatin']

entities_list: @entity1943 :: ('MESH:D013004', 'Chemical') :: ['somatostatin']

answer: @entity70671 :: (MESH:C099323,Chemical) :: ['cortistatin']


abstract: Telomerase-deficient mutants of @entity375 can survive death by senescence by using one of two homologous recombination pathways. The @entity11023 pathway amplifies the subtelomeric Y' sequences, while the @entity12248 pathway amplifies the telomeric TG(1-3) repeats. Here we show that telomerase-negative cells require @entity20495 (the major B-type cyclin in this organism), in association with @entity11869 ( @entity11869 ), to generate postsenescence survivors at a normal rate. The @entity12248 pathway was more sensitive to the absence of @entity20495 than the @entity11023 pathway. We also report that telomerase @entity12248 @entity11023 triple mutants still generated postsenescence survivors. This novel @entity12248 - and @entity11023 -independent pathway of telomeric recombination also appeared to be controlled by @entity20495 . In telomerase-positive cells, a synthetic growth defect between mutations in @entity20495 and @entity12248 or in its partners in the conserved MRX complex, @entity42182 and @entity42183 , was observed. This genetic interaction was independent of @entity42182 nuclease activity but was dependent on a DNA repair function. The present data reveal an unexpected role of @entity11869 / @entity20495 in telomeric recombination during telomerase-independent maintenance of telomeres. They also uncover a functional interaction between @entity11869 / @entity20495 and MRX during the control of the mitotic cell cycle.

title: Mitotic cyclins regulate telomeric recombination in telomerase-deficient XXXX cells.

entities_list: @entity375 :: ('4932', 'Species') :: ['Saccharomyces cerevisiae']

answer: @entity375 :: (4932,Species) :: ['yeast']


abstract: The signaling molecule @entity842 (NO) could engage multiple pathways to influence cellular function. Unraveling their relative biological importance has been difficult because it has not been possible to administer NO under the steady-state conditions that are normally axiomatic for analyzing ligand-receptor interactions and downstream signal transduction. To address this problem, we devised a chemical method for generating constant NO concentrations, derived from balancing NO release from a @entity26890 donor with NO consumption by a sink. On theoretical grounds, @entity6706 ( @entity6706 ) was selected as the sink. The mixture additionally contained urate to convert an unwanted product of the reaction ( @entity6836 ) into @entity3542 ions. The method enabled NO concentrations covering the physiological range (0-100 nM) to be formed within approximately 1 s. Moreover, the concentrations were sufficiently stable over at least several minutes to be useful for biological purposes. When applied to the activation of guanylyl cyclase-coupled NO receptors, the method gave an EC50 of 1.7 nM NO for the protein purified from @entity291 lung, which is lower than estimated previously using a biological NO sink (red blood cells). The corresponding values for the alpha1beta1 and alpha2beta1 isoforms were 0.9 nM and 0.5 nM, respectively. The slopes of the concentration-response curves were more shallow than before (Hill coefficient of 1 rather than 2), questioning the need to consider the binding of more than one NO molecule for receptor activation. The discrepancies are ascribable to limitations of the earlier method. Other biological problems can readily be addressed by adaptations of the new method.

title: A new and simple method for delivering clamped XXXX concentrations in the physiological range: application to activation of guanylyl cyclase-coupled @entity842 receptors.

entities_list: @entity6706 :: ('MESH:C079393', 'Chemical') :: ['CPTIO', '2-4-carboxyphenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide']

entities_list: @entity3542 :: ('CHEBI:16301', 'Chemical') :: ['nitrite']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: The signaling molecule @entity842 (NO) could engage multiple pathways to influence cellular function. Unraveling their relative biological importance has been difficult because it has not been possible to administer NO under the steady-state conditions that are normally axiomatic for analyzing ligand-receptor interactions and downstream signal transduction. To address this problem, we devised a chemical method for generating constant NO concentrations, derived from balancing NO release from a @entity26890 donor with NO consumption by a sink. On theoretical grounds, @entity6706 ( @entity6706 ) was selected as the sink. The mixture additionally contained urate to convert an unwanted product of the reaction ( @entity6836 ) into @entity3542 ions. The method enabled NO concentrations covering the physiological range (0-100 nM) to be formed within approximately 1 s. Moreover, the concentrations were sufficiently stable over at least several minutes to be useful for biological purposes. When applied to the activation of guanylyl cyclase-coupled NO receptors, the method gave an EC50 of 1.7 nM NO for the protein purified from @entity291 lung, which is lower than estimated previously using a biological NO sink (red blood cells). The corresponding values for the alpha1beta1 and alpha2beta1 isoforms were 0.9 nM and 0.5 nM, respectively. The slopes of the concentration-response curves were more shallow than before (Hill coefficient of 1 rather than 2), questioning the need to consider the binding of more than one NO molecule for receptor activation. The discrepancies are ascribable to limitations of the earlier method. Other biological problems can readily be addressed by adaptations of the new method.

title: A new and simple method for delivering clamped @entity842 concentrations in the physiological range: application to activation of guanylyl cyclase-coupled XXXX receptors.

answer: @entity842 :: (MESH:D009569,Chemical) :: ['nitric oxide']


abstract: OBJECTIVES: The lack of agreement regarding assessment methods is responsible for the variability in the reported rate of occurrence of @entity1057 after @entity64 . The aim of this study was to assess the sensitivity of different tests of neglect after right hemisphere @entity64 . METHODS: Two hundred and six subacute right hemisphere @entity64 @entity1 were given a test battery including a preliminary assessment of @entity1054 and of visual extinction, a clinical assessment of gaze orientation and of personal neglect, and paper and pencil tests of @entity1057 in the peripersonal space. @entity1 were compared with a previously reported control group. A subgroup of @entity1 (n=69) received a behavioural assessment of neglect in daily life situations. RESULTS: The most sensitive paper and pencil measure was the starting point in the cancellation task. The whole battery was more sensitive than any single test alone. About 85% of @entity1 presented some degree of neglect on at least one measure. An important finding was that behavioural assessment of neglect in daily life was more sensitive than any other single measure of neglect. Behavioural neglect was considered as moderate to severe in 36% of cases. A factorial analysis revealed that paper and pencil tests were related to two underlying factors. Dissociations were found between extrapersonal neglect, personal neglect, @entity1054 , and extinction. Anatomical analyses showed that neglect was more common and severe when the posterior association cortex was damaged. CONCLUSIONS: The automatic rightward orientation bias is the most sensitive clinical measure of neglect. Behavioural assessment is more sensitive than any single paper and pencil test. The results also support the assumption that neglect is a @entity74 .

title: Sensitivity of clinical and behavioural tests of @entity1057 after right hemisphere XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1057 :: ('MESH:D058069', 'Disease') :: ['spatial neglect']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['heterogeneous disorder']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['anosognosia']

answer: @entity64 :: (MESH:D020521,Disease) :: ['stroke']


abstract: OBJECTIVES: The lack of agreement regarding assessment methods is responsible for the variability in the reported rate of occurrence of @entity1057 after @entity64 . The aim of this study was to assess the sensitivity of different tests of neglect after right hemisphere @entity64 . METHODS: Two hundred and six subacute right hemisphere @entity64 @entity1 were given a test battery including a preliminary assessment of @entity1054 and of visual extinction, a clinical assessment of gaze orientation and of personal neglect, and paper and pencil tests of @entity1057 in the peripersonal space. @entity1 were compared with a previously reported control group. A subgroup of @entity1 (n=69) received a behavioural assessment of neglect in daily life situations. RESULTS: The most sensitive paper and pencil measure was the starting point in the cancellation task. The whole battery was more sensitive than any single test alone. About 85% of @entity1 presented some degree of neglect on at least one measure. An important finding was that behavioural assessment of neglect in daily life was more sensitive than any other single measure of neglect. Behavioural neglect was considered as moderate to severe in 36% of cases. A factorial analysis revealed that paper and pencil tests were related to two underlying factors. Dissociations were found between extrapersonal neglect, personal neglect, @entity1054 , and extinction. Anatomical analyses showed that neglect was more common and severe when the posterior association cortex was damaged. CONCLUSIONS: The automatic rightward orientation bias is the most sensitive clinical measure of neglect. Behavioural assessment is more sensitive than any single paper and pencil test. The results also support the assumption that neglect is a @entity74 .

title: Sensitivity of clinical and behavioural tests of XXXX after right hemisphere @entity64 .

answer: @entity1057 :: (MESH:D058069,Disease) :: ['spatial neglect']


abstract: @entity19865 also known as histiocytic necrotizing @entity3298 is a rare cervical inflammatory @entity3298 that is most commonly seen in young Asian @entity1 . It is mainly characterized by lymphadenopathy, @entity828 , @entity221 , nocturnal sweats, @entity925 , @entity353 , and @entity4841 , and commonly follows a self-limited course. The differential diagnosis is challenging as many other conditions such as @entity706 , @entity3 , @entity378 and infectious lymphadenopathies can present in a similar way. We present an unusual case of @entity19865 masquerading as metastatic @entity1377 of the thyroid. A 30-year-old young female presented, 2 months post-partum, with complaints of @entity4048 and @entity221 . A computed tomography scan showed enlarged right-sided lymph nodes and a thyroid nodule. Subsequent biopsy of a thyroid nodule revealed @entity3557 and reactive @entity32 in one of the lymph nodes. She underwent an elective total thyroidectomy, central node dissection and a right modified lymph node dissection for enlarged lymph nodes. Her recovery was uneventful and the pathology report was consistent with a @entity1377 of the thyroid with one lymph node positive for @entity3 and several other lymph nodes showing histiocytic necrotizing @entity3298 . This coexistence of @entity19865 with localized metastatic @entity3557 is unusual and presents an interesting, challenging, and complex management dilemma.

title: XXXX Masquerading as Metastatic @entity1377 of the Thyroid.

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinoma']

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid carcinoma', 'papillary thyroid cancer']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity3298 :: ('MESH:D008199', 'Disease') :: ['lymphadenitis']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['malignant lymphoma']

entities_list: @entity828 :: ('MESH:C535727', 'Disease') :: ['hepatosplenomegaly']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']

entities_list: @entity19865 :: ('MESH:D020042', 'Disease') :: ['Kikuchi-Fujimoto disease']

entities_list: @entity4841 :: ('MESH:D018771', 'Disease') :: ['arthralgia']

entities_list: @entity378 :: ('MESH:D014376', 'Disease') :: ['tuberculosis']

answer: @entity19865 :: (MESH:D020042,Disease) :: ['Kikuchi-Fujimoto Disease']


abstract: @entity19865 also known as histiocytic necrotizing @entity3298 is a rare cervical inflammatory @entity3298 that is most commonly seen in young Asian @entity1 . It is mainly characterized by lymphadenopathy, @entity828 , @entity221 , nocturnal sweats, @entity925 , @entity353 , and @entity4841 , and commonly follows a self-limited course. The differential diagnosis is challenging as many other conditions such as @entity706 , @entity3 , @entity378 and infectious lymphadenopathies can present in a similar way. We present an unusual case of @entity19865 masquerading as metastatic @entity1377 of the thyroid. A 30-year-old young female presented, 2 months post-partum, with complaints of @entity4048 and @entity221 . A computed tomography scan showed enlarged right-sided lymph nodes and a thyroid nodule. Subsequent biopsy of a thyroid nodule revealed @entity3557 and reactive @entity32 in one of the lymph nodes. She underwent an elective total thyroidectomy, central node dissection and a right modified lymph node dissection for enlarged lymph nodes. Her recovery was uneventful and the pathology report was consistent with a @entity1377 of the thyroid with one lymph node positive for @entity3 and several other lymph nodes showing histiocytic necrotizing @entity3298 . This coexistence of @entity19865 with localized metastatic @entity3557 is unusual and presents an interesting, challenging, and complex management dilemma.

title: @entity19865 Masquerading as Metastatic XXXX of the Thyroid.

answer: @entity1377 :: (MESH:D002291,Disease) :: ['Papillary Carcinoma']


abstract: OBJECTIVE: This investigation explored the relationship of coping responses and parental history of @entity101 to task-induced blood pressure changes. MATERIALS AND METHODS: The sample consisted of 215 black college student volunteers (median age = 25.95 y). During the speaking task, @entity1 responded to standardized questions about perceptions of intra-ethnic and inter-ethnic group racism. Systolic blood pressure and diastolic blood pressure were measured via an automated blood pressure monitor. Usual ways of coping with intra-ethnic group racism were assessed with the @entity5786 Scale, and parental history of @entity101 (PHH) was self-reported by @entity1 . RESULTS: Findings from the final step of hierarchical general linear models indicated that the main effect of emotion-focused coping was negatively associated with diastolic blood pressure (p = 0.02) and systolic blood pressure (p = 0.002) changes. Further, these analyses revealed that PHH interacted: (1) with the coping responses of planning (p = 0.007) and denial (p = 0.002) to predict changes in systolic blood pressure and (2) with the planning coping response to predict diastolic blood pressure changes (p = 0.02). The direction of these effects indicated that among @entity1 who were high in these coping responses, @entity1 who also had a positive PHH had larger blood pressure changes. Regression analyses also revealed that PHH interacted with the cognitive coping response (p = 0.01) to predict changes in systolic blood pressure. The direction of this effect indicated that among @entity1 who were low in this coping response, @entity1 who also had a positive PHH had larger systolic blood pressure changes. CONCLUSION: This study highlights the importance of examining the joint contribution of biological and psychosocial parameters to blood pressure reactivity in blacks.

title: Parental history of XXXX and coping responses predict blood pressure changes in black college volunteers undergoing a speaking task about perceptions of racism.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: Exercise training decreases blood viscosity in athletes parallel with metabolic improvements mostly characterized by an @entity1720 . @entity1 with @entity258 exhibit a host of @entity209 that may also benefit from regular training. However, the hemorheologic aspects of training in such subjects are not known and we aimed at characterizing them. SUBJECTS: Thirty-two @entity28 insulin resistant subjects were tested before and after 2 months. Twenty-one of them were trained (3x45 min/wk) at a level defined by exercise calorimetry and corresponding to the power at which lipid oxidation reaches a maximum (LIPOX(max )) and eleven served as controls. The two groups were matched for age and body mass index. There was no weight change in controls while the 2 months training period decreased weight by 2.5 kg (p<0.02). This change was totally explained by a loss in fat mass (-2.7 kg, p<0.02) while fat free mass remained unchanged. Blood rheology was unchanged in the control group while training improved plasma viscosity @entity2231 (pl) (before: 1.43+/-0.03 mPa.s; after: 1.35+/-0.03 mPa.s, p<0.02). There was no change in either hematocrit, @entity2003 or red cell aggregation. The balance of substrates oxidation shifted towards a higher use of lipids (point of crossover where subjects oxidize 70% @entity3363 30% lipids: before 39.3+/-6.9 watts; after 70.8+/-6 watts, p<0.001; point where lipid oxidation is maximal (LIPOX(max )) before: 16.5+/-1.4 watts; after: 21.4+/-1.3 watts, p<0.001) and V(O(2max )) increased by 74% (p<0.01). Consistent with observations in athletes, the metabolic and ergometric improvements induced by training reduces @entity2231 (pl) in sedentary, insulin resistant @entity1 , but at those low levels training does not appear to induce "autohemodilution" (as reflected by hematocrit) neither it improves red cell deformability or aggregation. The reliability of @entity2231 (pl) as simple and unexpensive marker of efficiency of training in insulin resistant @entity1 should be further evaluated.

title: Regular exercise (3x45 min/wk) decreases plasma viscosity in sedentary XXXX , insulin resistant @entity1 parallel to an improvement in fitness and a shift in substrate oxidation balance.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['red cell rigidity']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic disorders']

entities_list: @entity1720 :: ('MESH:D007333', 'Disease') :: ['increase in insulin sensitivity']

entities_list: @entity258 :: ('MESH:D009800', 'Disease') :: ['low insulin sensitivity']

entities_list: @entity3363 :: ('MESH:D002241', 'Chemical') :: ['carbohydrates']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obese']


abstract: Exercise training decreases blood viscosity in athletes parallel with metabolic improvements mostly characterized by an @entity1720 . @entity1 with @entity258 exhibit a host of @entity209 that may also benefit from regular training. However, the hemorheologic aspects of training in such subjects are not known and we aimed at characterizing them. SUBJECTS: Thirty-two @entity28 insulin resistant subjects were tested before and after 2 months. Twenty-one of them were trained (3x45 min/wk) at a level defined by exercise calorimetry and corresponding to the power at which lipid oxidation reaches a maximum (LIPOX(max )) and eleven served as controls. The two groups were matched for age and body mass index. There was no weight change in controls while the 2 months training period decreased weight by 2.5 kg (p<0.02). This change was totally explained by a loss in fat mass (-2.7 kg, p<0.02) while fat free mass remained unchanged. Blood rheology was unchanged in the control group while training improved plasma viscosity @entity2231 (pl) (before: 1.43+/-0.03 mPa.s; after: 1.35+/-0.03 mPa.s, p<0.02). There was no change in either hematocrit, @entity2003 or red cell aggregation. The balance of substrates oxidation shifted towards a higher use of lipids (point of crossover where subjects oxidize 70% @entity3363 30% lipids: before 39.3+/-6.9 watts; after 70.8+/-6 watts, p<0.001; point where lipid oxidation is maximal (LIPOX(max )) before: 16.5+/-1.4 watts; after: 21.4+/-1.3 watts, p<0.001) and V(O(2max )) increased by 74% (p<0.01). Consistent with observations in athletes, the metabolic and ergometric improvements induced by training reduces @entity2231 (pl) in sedentary, insulin resistant @entity1 , but at those low levels training does not appear to induce "autohemodilution" (as reflected by hematocrit) neither it improves red cell deformability or aggregation. The reliability of @entity2231 (pl) as simple and unexpensive marker of efficiency of training in insulin resistant @entity1 should be further evaluated.

title: Regular exercise (3x45 min/wk) decreases plasma viscosity in sedentary @entity28 , insulin resistant XXXX parallel to an improvement in fitness and a shift in substrate oxidation balance.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVES/HYPOTHESIS: This study examined the role of the pulsed-dye laser (PDL) at 585 nm coupled with @entity1968 at therapeutic (5.0 mg/kg) and nontherapeutic (0.5 mg/kg) doses to delay the progression of @entity5 with a two-hit approach. The existing vasculature is selectively targeted by the laser, whereas @entity1968 inhibits future angiogenesis. STUDY DESIGN: Randomized, prospective study in a @entity19 model. METHODS: Twenty-five athymic @entity19 were inoculated with oral @entity1544 on six flank sites and randomly divided into five groups: 1) control subjects, 2) treatment with 0.5 mg/kg @entity1968 ( @entity309 0.5), 3) treatment with 5.0 mg/kg @entity1968 ( @entity309 5.0), 4) treatment with @entity309 0.5 + PDL, and 5) treatment with @entity309 5.0 + PDL. The PDL groups received irradiation after inoculation. The @entity1968 was administered daily. The @entity5 were counted and measured for 14 days. RESULTS: The control group developed visible @entity5 in 50% of the inoculation sites at 3 days compared with 3 days ( @entity309 0.5) and 4 days ( @entity309 5.0) for the @entity1968 groups and 9 days ( @entity309 0.5 + PDL) and 10 days ( @entity309 5.0 + PDL) for the laser treatment groups. There was no @entity5 growth until day 7 in the @entity309 5.0 + PDL group. The @entity5 volume was statistically different between the treatment groups. CONCLUSION: This study demonstrated the superiority of a single treatment with the PDL coupled with @entity1968 to delay the progression of @entity5 when compared with treatment with @entity1968 alone, thus introducing a novel strategy in @entity5 control.

title: Pulsed-dye laser and XXXX delay progression of oral squamous cell carcinoma: a @entity19 model.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'tumors']

entities_list: @entity19 :: ('10090', 'Species') :: ['nude mice', 'murine']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous cell cancers']

entities_list: @entity1968 :: ('MESH:D014212', 'Chemical') :: ['retinoic acid']

answer: @entity1968 :: (MESH:D014212,Chemical) :: ['retinoic acid']


abstract: OBJECTIVES/HYPOTHESIS: This study examined the role of the pulsed-dye laser (PDL) at 585 nm coupled with @entity1968 at therapeutic (5.0 mg/kg) and nontherapeutic (0.5 mg/kg) doses to delay the progression of @entity5 with a two-hit approach. The existing vasculature is selectively targeted by the laser, whereas @entity1968 inhibits future angiogenesis. STUDY DESIGN: Randomized, prospective study in a @entity19 model. METHODS: Twenty-five athymic @entity19 were inoculated with oral @entity1544 on six flank sites and randomly divided into five groups: 1) control subjects, 2) treatment with 0.5 mg/kg @entity1968 ( @entity309 0.5), 3) treatment with 5.0 mg/kg @entity1968 ( @entity309 5.0), 4) treatment with @entity309 0.5 + PDL, and 5) treatment with @entity309 5.0 + PDL. The PDL groups received irradiation after inoculation. The @entity1968 was administered daily. The @entity5 were counted and measured for 14 days. RESULTS: The control group developed visible @entity5 in 50% of the inoculation sites at 3 days compared with 3 days ( @entity309 0.5) and 4 days ( @entity309 5.0) for the @entity1968 groups and 9 days ( @entity309 0.5 + PDL) and 10 days ( @entity309 5.0 + PDL) for the laser treatment groups. There was no @entity5 growth until day 7 in the @entity309 5.0 + PDL group. The @entity5 volume was statistically different between the treatment groups. CONCLUSION: This study demonstrated the superiority of a single treatment with the PDL coupled with @entity1968 to delay the progression of @entity5 when compared with treatment with @entity1968 alone, thus introducing a novel strategy in @entity5 control.

title: Pulsed-dye laser and @entity1968 delay progression of oral squamous cell carcinoma: a XXXX model.

answer: @entity19 :: (10090,Species) :: ['murine']


abstract: OBJECTIVE/HYPOTHESIS: To reconcile conflicting reports and opinions of the value of @entity3459 studies for @entity1 undergoing tonsillectomy. STUDY DESIGN: Meta-analysis: Articles were identified by MEDLINE search, references from review articles, textbook chapter, and retrieved reports. Independent observers selected prospective trials of @entity1 undergoing tonsillectomy or adenoidectomy and tonsillectomy. Retrospective studies meeting other inclusion and exclusion criteria were included for sensitivity analyses of results. METHODS: Data were abstracted from studies for an end point of @entity548 with normal and @entity854 tests. Four prospective studies met all inclusion and exclusion criteria. These four studies were used in the data synthesis. An additional eight retrospective studies met all other criteria and were used in the sensitivity analysis. RESULTS: Pooled analysis of 3384 @entity1 revealed a rate of 3.3% (95% confidence interval [CI], 2.5%-4.1%) for post-tonsillectomy @entity548 in @entity1 with normal coagulation studies. A rate of 8.7% (95% CI, 1.5%-15.9%) was obtained for @entity548 in @entity1 with @entity854 studies. No significant rate difference in post-tonsillectomy @entity548 was demonstrated. CONCLUSION: There is no difference in the rate of post-tonsillectomy @entity548 in @entity1 with @entity854 studies as compared with @entity1 with normal coagulation studies obtained preoperatively.

title: XXXX : a meta-analysis.

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['preoperative coagulation']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity854 :: ('MESH:D018376', 'Disease') :: ['abnormal coagulation']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

answer: @entity548 :: (MESH:D006470,Disease) :: ['Post-tonsillectomy bleeding']


abstract: BACKGROUND: @entity14 prevalence is an important determinant of the health demand that completes information provided by @entity5 incidence. Current estimations established from data for the years 1985 and 1995 can be used to establish a precise description of changing healthcare needs for @entity14 . METHOD: Prevalence estimates method were based on incidence data computed on the regional scale by the FRANCIM network and mortality data provided by INSERM. We used the relationship that exists between the net risk of @entity5 , the net risk of dying of the given @entity5 and the age-specific prevalence of @entity5 . RESULTS: In 1995, the prevalence of @entity1 who had a diagnosis of @entity14 amounted to 200 000 @entity1 . The estimated number of prevalent cases was never lower than 3500 in any region and in 7 regions this number was higher than 10 000. From 1985 to 1995, there has been an increase of 35% in the prevalence rates. CONCLUSION: The evaluation of the number of @entity1 who have had a diagnosis of @entity14 provides knowledge for health care planning. Such information on the regional scale is very useful for the health organisation (SROS). This geographical level induces difficulties not encountered at the national level.

title: [Estimate of regional prevalence of XXXX in France].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'persons']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['Colorectal cancer', 'colorectal cancer']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: PURPOSE: To evaluate survival, @entity3 , @entity5 @entity39 , and prediction of local recurrence after percutaneous ultrasonographically (US) guided radiofrequency (RF) thermal ablation with electrodes perfused continuously with isotonic saline. MATERIALS AND METHODS: VX2 @entity96 were implanted in 31 @entity95 according to a standardized protocol. After 21 days, 16 animals were treated percutaneously with RF ablation. Four animals died of complications related to anesthesia, and 12 animals were evaluated. All animals were followed for 110 days and monitored with computed tomography (CT) and US at 1, 7, and 30 days. A control group of 15 animals did not receive treatment. Autopsy was performed at the end of scheduled follow-up or immediately after @entity204 . For survival analysis, the Kaplan-Meier method was used; for nominal data, the Fisher exact test was used. RESULTS: In comparison to controls, animals in the treatment group showed significantly prolonged survival (P <.001). Eight of 12 animals (67%) treated with RF ablation survived to 110 days, while none of the controls did so. @entity3 developed in all controls (100%) and in eight of 12 treated animals (67%) (P =.001). In comparison with controls, animals that developed @entity3 despite treatment also showed significantly prolonged survival (P =.02). Local recurrence was observed in three of 12 animals (25%) in the treatment group. CT and US performed 1 week after treatment did not allow prediction of local recurrence. CONCLUSION: RF ablation of @entity96 with perfused needle applicators prolongs survival in the VX2 @entity95 @entity96 model, regardless of whether complete remission is achieved. In comparison with controls, RF ablation results in a lower frequency of @entity3 .

title: Percutaneous US-guided radiofrequency ablation with perfused needle applicators: improved survival with the VX2 @entity5 model in XXXX .

entities_list: @entity96 :: ('MESH:D008113', 'Disease') :: ['liver tumors', 'liver tumor']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'Metastases']

answer: @entity95 :: (9986,Species) :: ['rabbits']


abstract: PURPOSE: To evaluate survival, @entity3 , @entity5 @entity39 , and prediction of local recurrence after percutaneous ultrasonographically (US) guided radiofrequency (RF) thermal ablation with electrodes perfused continuously with isotonic saline. MATERIALS AND METHODS: VX2 @entity96 were implanted in 31 @entity95 according to a standardized protocol. After 21 days, 16 animals were treated percutaneously with RF ablation. Four animals died of complications related to anesthesia, and 12 animals were evaluated. All animals were followed for 110 days and monitored with computed tomography (CT) and US at 1, 7, and 30 days. A control group of 15 animals did not receive treatment. Autopsy was performed at the end of scheduled follow-up or immediately after @entity204 . For survival analysis, the Kaplan-Meier method was used; for nominal data, the Fisher exact test was used. RESULTS: In comparison to controls, animals in the treatment group showed significantly prolonged survival (P <.001). Eight of 12 animals (67%) treated with RF ablation survived to 110 days, while none of the controls did so. @entity3 developed in all controls (100%) and in eight of 12 treated animals (67%) (P =.001). In comparison with controls, animals that developed @entity3 despite treatment also showed significantly prolonged survival (P =.02). Local recurrence was observed in three of 12 animals (25%) in the treatment group. CT and US performed 1 week after treatment did not allow prediction of local recurrence. CONCLUSION: RF ablation of @entity96 with perfused needle applicators prolongs survival in the VX2 @entity95 @entity96 model, regardless of whether complete remission is achieved. In comparison with controls, RF ablation results in a lower frequency of @entity3 .

title: Percutaneous US-guided radiofrequency ablation with perfused needle applicators: improved survival with the VX2 XXXX model in @entity95 .

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']


abstract: STUDY DESIGN: A cross-sectional survey of 806 pupils in Odense, Denmark was performed. This survey included @entity1 and adolescents ages 8 to 10 and 14 to 16 years obtained through two-stage cluster sampling from schools stratified according to school type, location, and socioeconomic character of the uptake area. OBJECTIVES: To establish the 1-month prevalence of neck, middle back, and @entity1643 and the consequences this disorder may have in relation to age and gender. SUMMARY OF BACKGROUND DATA: The @entity615 and the variety of age groups included in previous studies make it difficult to draw clear conclusions about the onset of @entity158 for various spinal regions in the young. METHODS: Information on back @entity158 within the preceding month, obtained through a standardized interview of 481 @entity1 and 325 adolescents, was categorized according to area of @entity158 , age, and gender. The consequences of back @entity158 also were studied. RESULTS: The 1-month prevalence of back @entity158 was 39%. @entity158 is most common in childhood, whereas @entity158 and @entity158 are equally common in adolescence. Neck @entity158 and @entity158 in more than one area of the spine are rare in both age groups. No gender differences were found. Of those who had back @entity158 , 38% also reported some type of consequence, usually either visits to a medical physician or diminished physical activities. CONCLUSIONS: For clinical and research purposes, @entity4048 , @entity615 , and @entity1643 in childhood should be regarded as three specific entities. In future research the data for different age groups should be reported separately.

title: XXXX reporting pattern in a Danish population-based sample of @entity1 and adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['differences in definitions of back pain', 'middle back pain']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['lumbar pain', 'Thoracic pain', 'pain', 'thoracic pain']

answer: @entity615 :: (MESH:D001416,Disease) :: ['Back pain']


abstract: STUDY DESIGN: A cross-sectional survey of 806 pupils in Odense, Denmark was performed. This survey included @entity1 and adolescents ages 8 to 10 and 14 to 16 years obtained through two-stage cluster sampling from schools stratified according to school type, location, and socioeconomic character of the uptake area. OBJECTIVES: To establish the 1-month prevalence of neck, middle back, and @entity1643 and the consequences this disorder may have in relation to age and gender. SUMMARY OF BACKGROUND DATA: The @entity615 and the variety of age groups included in previous studies make it difficult to draw clear conclusions about the onset of @entity158 for various spinal regions in the young. METHODS: Information on back @entity158 within the preceding month, obtained through a standardized interview of 481 @entity1 and 325 adolescents, was categorized according to area of @entity158 , age, and gender. The consequences of back @entity158 also were studied. RESULTS: The 1-month prevalence of back @entity158 was 39%. @entity158 is most common in childhood, whereas @entity158 and @entity158 are equally common in adolescence. Neck @entity158 and @entity158 in more than one area of the spine are rare in both age groups. No gender differences were found. Of those who had back @entity158 , 38% also reported some type of consequence, usually either visits to a medical physician or diminished physical activities. CONCLUSIONS: For clinical and research purposes, @entity4048 , @entity615 , and @entity1643 in childhood should be regarded as three specific entities. In future research the data for different age groups should be reported separately.

title: @entity615 reporting pattern in a Danish population-based sample of XXXX and adolescents.

answer: @entity1 :: (9606,Species) :: ['children']


abstract: In the @entity5157 , @entity70672 and @entity9838 are described as alarm substances. We asked whether both substances have a similar role by testing the effect of their exposure on the appetitive proboscis extension reflex and on the aversive stinging reflex. In the appetitive context of @entity969 stimulation no differences were found between @entity70672 and @entity9838 . Small amounts of @entity70672 or @entity9838 (3 microl of 1:9 dilution) yielded a response similar to that of a non-exposed control. Larger amounts of both substances (125 microl of 1:9 dilutions) as well as mixtures led to a decrease of responsiveness to @entity969 . In the aversive context of electrical stimulation, significant differences between @entity70672 and @entity9838 were found. Exposure to a small amount of @entity70672 (3 microl of 1:9 dilution) or to a large amount of @entity9838 (125 microl of 1:9 dilution) led to an increase of responsiveness to the electric shock. Larger quantities of @entity70672 (125 microl of 1:9 dilution) decreased the responsiveness to the shock. @entity9838 never decreased the responsiveness to the shock. Our results indicate that @entity70672 and @entity9838 have different functions even if both are capable of evoking deterrent responses in a defensive context.

title: Different functions of two alarm substances in the XXXX .

entities_list: @entity70672 :: ('CHEBI:31725', 'Chemical') :: ['isopentyl acetate']

entities_list: @entity9838 :: ('MESH:C011917', 'Chemical') :: ['2-heptanone', '2-Heptanone']

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

answer: @entity5157 :: (7460,Species) :: ['honeybee']


abstract: OBJECTIVE: There has been little research into @entity74 . While, Peji   carried out a study some 50 years ago, and Grymer more recently suggested that some @entity85 could be inherited, both studies lack a precise definition of the types of @entity85 which were investigated. The aim of this paper is to investigate the hypothetic influence of heredity on the onset of particular types of @entity85 . The authors investigated a very particular and well defined type of @entity85 after Mladina's classification. METHODS: The authors studied a group of 22 @entity1 among 779 @entity1 aged 7-14, selected at random, suffering from @entity85 and their 44 parents. They were examined by means of anterior rhinoscopy by two the same ENT specialists in rhinology. The control group consisted of 24 @entity1 with a straight nasal septum of the same age and sex distribution and their 48 parents. The results were compared using Fisher's exact probability test. RESULTS: In the studied group @entity85 was found in 21 out of 22 both fathers and mothers of these @entity1 . Type 6 was not found in any of 48 parents of @entity1 with no @entity85 . CONCLUSIONS: There is a high positive correlation between the appearance of @entity85 in both mothers and fathers of @entity1 with this @entity85 . The high correlation in the incidence of type 6 @entity85 in mothers and their @entity1 and in fathers and their @entity1 suggests that this type of @entity85 is inherited. Most authors hold that only @entity85 result from inheritance factors, while @entity85 result from environmental factors, that is, from injury to the nose and the central massif of the face. However, our study of type 6 deformities shows that certain types of @entity85 can be inherited.

title: Are some septal XXXX revisited.

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['septal deformities', 'posterior septal deformities', 'type 6 septal deformity', 'nasal deformity', 'type of deformity', 'type 6 septal deformities', 'anterior deformities', 'septal deformity', 'septal deformity: type 6']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited septal deformities']

answer: @entity74 :: (MESH:D030342,Disease) :: ['deformities inherited? Type 6']


abstract: OBJECTIVE: Facial nerve (FN) anomalies are exceedingly rare. The association between a @entity393 and an anomalous @entity2103 has never been touched deeply in the literature. The aim of this study is to report @entity2103 in @entity1 presenting with @entity393 ( @entity393 ) and/or @entity2103 . METHODS: A retrospective chart review over 10 years from two academic tertiary referral centers. Eight @entity1 were diagnosed with @entity2103 in association with @entity393 . The age ranged from 7 months to 13 years. RESULTS: Five @entity1 had conductive @entity393 (CCHL). Two had congenital @entity1274 (CSNHL). The eighth @entity1 had a @entity393 ( @entity393 ). Surgical findings for @entity1 with conductive @entity393 included @entity2103 passing @entity75 (OW) (two @entity1 ), @entity2103 covering head of stapes (three @entity1 ), deformed stapes (two @entity1 ), deformed incus (two @entity1 ), and absent incus (one @entity1 ). Radiological findings for @entity1 with congenital @entity1274 and @entity393 include, @entity154 (one @entity1 ), dilated vestibule and superior semicircular canal (one @entity1 ), and absent internal auditory canal (IAC) (two @entity1 ). For @entity1 with conductive @entity393 , the radiological findings consistency demonstrates a soft tissue opacification in the middle ear. CONCLUSIONS: @entity393 may be associated with @entity2103 . Pediatric otolaryngologists should be cautious when exploring @entity1 with conductive @entity393 .

title: @entity2103 in association with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity154 :: ('MESH:D000013', 'Disease') :: ['single cavity anomaly']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['inferior to oval window']

entities_list: @entity2103 :: ('MESH:D005155', 'Disease') :: ['facial nerve', 'facial nerve anomalies', 'facial nerve palsy']

entities_list: @entity1274 :: ('MESH:D006319', 'Disease') :: ['sensorineural hearing loss']

entities_list: @entity393 :: ('MESH:D034381', 'Disease') :: ['Congenital hearing loss', 'congenital hearing loss', 'COHL', 'MHL', 'hearing loss', 'mixed hearing loss']

answer: @entity393 :: (MESH:D034381,Disease) :: ['congenital hearing loss']


abstract: OBJECTIVE: Facial nerve (FN) anomalies are exceedingly rare. The association between a @entity393 and an anomalous @entity2103 has never been touched deeply in the literature. The aim of this study is to report @entity2103 in @entity1 presenting with @entity393 ( @entity393 ) and/or @entity2103 . METHODS: A retrospective chart review over 10 years from two academic tertiary referral centers. Eight @entity1 were diagnosed with @entity2103 in association with @entity393 . The age ranged from 7 months to 13 years. RESULTS: Five @entity1 had conductive @entity393 (CCHL). Two had congenital @entity1274 (CSNHL). The eighth @entity1 had a @entity393 ( @entity393 ). Surgical findings for @entity1 with conductive @entity393 included @entity2103 passing @entity75 (OW) (two @entity1 ), @entity2103 covering head of stapes (three @entity1 ), deformed stapes (two @entity1 ), deformed incus (two @entity1 ), and absent incus (one @entity1 ). Radiological findings for @entity1 with congenital @entity1274 and @entity393 include, @entity154 (one @entity1 ), dilated vestibule and superior semicircular canal (one @entity1 ), and absent internal auditory canal (IAC) (two @entity1 ). For @entity1 with conductive @entity393 , the radiological findings consistency demonstrates a soft tissue opacification in the middle ear. CONCLUSIONS: @entity393 may be associated with @entity2103 . Pediatric otolaryngologists should be cautious when exploring @entity1 with conductive @entity393 .

title: XXXX in association with @entity393 .

answer: @entity2103 :: (MESH:D005155,Disease) :: ['Facial nerve anomalies']


abstract: The object of this report is to review the clinical outcomes of aortic valve-sparing operations in @entity1 with @entity449 . From May 1988 to June 2000, 120 @entity1 with @entity449 with or without @entity337 underwent aortic valve-sparing operations. There were 83 @entity1 and 37 @entity1 whose mean age was 46 years (range 16 to 72 years). Forty-eight @entity1 had the @entity1614 , and 22 had either @entity4432 . Reconstruction of the aortic root was performed using the technique of reimplanation of the aortic valve in 64 @entity1 and the remodeling of the aortic root in 56. The mean follow-up was 35 months (range 2 to 145 months), and it was complete. Aortic valve function was assessed by echocardiography. There were 2 operative and 5 late deaths. The 10-year survival for @entity1 with @entity449 was 88% +/- 4%. Two @entity1 have required aortic root replacement: one on the first postoperative day because of severe @entity337 and one paraplegic @entity1 12 years after surgery because of @entity884 with @entity2333 . Both @entity1 survived reoperation. The 10-year freedom from aortic root reoperation was 99% +/- 1%. Three @entity1 suffered transient @entity63 attacks. The 10-year freedom from @entity1031 events was 89% +/- 5%. Seven @entity1 had moderate @entity337 at the latest echocardiographic study. The 10-year freedom from severe or moderate @entity337 was 83% +/- 8%. Aortic valve-sparing operations have provided excellent clinical outcomes and few @entity340 . The function of the reconstructed aortic root remains unchanged in most @entity1 during the first decade of follow-up.

title: Aortic valve-sparing operations for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic root aneurysm']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemic']

entities_list: @entity1614 :: ('MESH:D008382', 'Disease') :: ['Marfan syndrome']

entities_list: @entity4432 :: ('MESH:D065290', 'Disease') :: ['acute or chronic type A aortic dissections']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic insufficiency']

entities_list: @entity1031 :: ('MESH:D013923', 'Disease') :: ['thromboembolic']

entities_list: @entity2333 :: ('MESH:D001018', 'Disease') :: ['aortic root abscess']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valve-related complications']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['infective endocarditis']

answer: @entity449 :: (MESH:D001014,Disease) :: ['aortic root aneurysm']


abstract: OBJECTIVE: To compare the inspiratory volume pressure (VP) curves of the respiratory system (rs) produced by static occlusion (OCC) and dynamic low constant flow inflation (LCFI) methods using a new device in @entity649 ( @entity649 ) @entity1 . SETTING: A multidisciplinary 24-bed ICU in a tertiary university hospital. @entity1 : Eleven intubated and mechanically ventilated @entity1 with @entity649 . MEASUREMENTS AND RESULTS: OCC and LCFI methods were performed using the same ventilator, which had been specifically implemented for this purpose. LCFI of 5, 10, and 15 l/min and OCC were applied in a random order at zero end-expiratory positive pressure. Airway pressure was measured both proximal (P(ao)) and distal (P(tr)) to the endotracheal tube. @entity1166 ( @entity1166 ) and maximal slope (C(max,rs)) were estimated using unbiased iterative linear regressions. @entity1166 (rs) was obtained in all @entity1 under LCFI and in nine @entity1 under OCC. With LCFI of 5, 10, 15 l/min and OCC the average @entity1166 (rs) values were 12.2 +/- 3.9, 12.9 +/- 4, 14.3 +/- 3.4, and 11.9 cm @entity2507 for P(ao) and 11.9 +/- 3.9, 11.5 +/- 3.3, 12.5 +/- 3.4 and 11.8 +/- 4.4 for P(tr), respectively. Only the mean values of @entity1166 (rs) for P(ao) with LCFI at 15 l/min were significantly different from those obtained for OCC. The C(max,rs) values found with the two methods were similar. CONCLUSIONS: An LCFI less than or equal to 10 l/min seems to be a quick, safe, and reliable method to determine @entity1166 (rs) and C(max,rs) at the bedside.

title: Inspiratory pressure-volume curves obtained using automated low constant flow inflation and automated occlusion methods in XXXX @entity1 with a new device.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity649 :: ('MESH:D012128', 'Disease') :: ['ARDS', 'acute respiratory distress syndrome']

entities_list: @entity1166 :: ('MESH:D016171', 'Disease') :: ['LIP', 'Lower inflection point']

answer: @entity649 :: (MESH:D012128,Disease) :: ['ARDS']


abstract: OBJECTIVE: To compare the inspiratory volume pressure (VP) curves of the respiratory system (rs) produced by static occlusion (OCC) and dynamic low constant flow inflation (LCFI) methods using a new device in @entity649 ( @entity649 ) @entity1 . SETTING: A multidisciplinary 24-bed ICU in a tertiary university hospital. @entity1 : Eleven intubated and mechanically ventilated @entity1 with @entity649 . MEASUREMENTS AND RESULTS: OCC and LCFI methods were performed using the same ventilator, which had been specifically implemented for this purpose. LCFI of 5, 10, and 15 l/min and OCC were applied in a random order at zero end-expiratory positive pressure. Airway pressure was measured both proximal (P(ao)) and distal (P(tr)) to the endotracheal tube. @entity1166 ( @entity1166 ) and maximal slope (C(max,rs)) were estimated using unbiased iterative linear regressions. @entity1166 (rs) was obtained in all @entity1 under LCFI and in nine @entity1 under OCC. With LCFI of 5, 10, 15 l/min and OCC the average @entity1166 (rs) values were 12.2 +/- 3.9, 12.9 +/- 4, 14.3 +/- 3.4, and 11.9 cm @entity2507 for P(ao) and 11.9 +/- 3.9, 11.5 +/- 3.3, 12.5 +/- 3.4 and 11.8 +/- 4.4 for P(tr), respectively. Only the mean values of @entity1166 (rs) for P(ao) with LCFI at 15 l/min were significantly different from those obtained for OCC. The C(max,rs) values found with the two methods were similar. CONCLUSIONS: An LCFI less than or equal to 10 l/min seems to be a quick, safe, and reliable method to determine @entity1166 (rs) and C(max,rs) at the bedside.

title: Inspiratory pressure-volume curves obtained using automated low constant flow inflation and automated occlusion methods in @entity649 XXXX with a new device.

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: To evaluate outcome and prognostic factors in Saudi Arabian @entity1 with metastatic @entity2828 and @entity6196 of bone (PMES) at diagnosis. PROCEDURE: Ninety-nine of 304 (33%) consecutive @entity1 with @entity2828 and @entity6196 of bone registered at our centre from 1975 to 1998, had metastatic disease at registration and 93 were available for analysis. The maximum x-axis diameter of the @entity5 was used as the measure of @entity5 size. Usually a trial of systemic treatment was undertaken before a decision was made on local treatment. Standard chemotherapy regimens were used in all treated @entity1 . Forty-one (44%) @entity1 did not receive radical local treatment due to an inadequate response to chemotherapy, or a decision not to undertake more than palliative treatment. Radical treatment of the primary site was radiation alone 41 (79%), resection alone 7 (13%), and resection and radiation 4 (8%). RESULTS: The 5-year survival rates were 9% for all 93 evaluable @entity1 , 16% for 52 @entity1 who received chemotherapy and radical local treatment, 0% for 41 @entity1 who received lesser treatment, 19% for 43 @entity1 with lung metastases alone, and 0% (P = 0.002) for 50 @entity1 with other sites involved. For 60 @entity1 with imaging data, 5-year survivals were 34 and 0% when the maximum transverse diameter of the @entity5 was < 10 cm (N = 20) and > or = 10 cm (N = 40), respectively. CONCLUSIONS: Small @entity5 size and the presence of lung metastases alone were the only significant favorable prognostic factors. Earlier diagnosis will be the basis for better results.

title: Metastatic @entity2828 / XXXX of bone at diagnosis: prognostic factors--a report from Saudi Arabia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2828 :: ('MESH:D012512', 'Disease') :: ['Ewing sarcoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumor']

answer: @entity6196 :: (MESH:D018242,Disease) :: ['PNET']


abstract: BACKGROUND: To evaluate outcome and prognostic factors in Saudi Arabian @entity1 with metastatic @entity2828 and @entity6196 of bone (PMES) at diagnosis. PROCEDURE: Ninety-nine of 304 (33%) consecutive @entity1 with @entity2828 and @entity6196 of bone registered at our centre from 1975 to 1998, had metastatic disease at registration and 93 were available for analysis. The maximum x-axis diameter of the @entity5 was used as the measure of @entity5 size. Usually a trial of systemic treatment was undertaken before a decision was made on local treatment. Standard chemotherapy regimens were used in all treated @entity1 . Forty-one (44%) @entity1 did not receive radical local treatment due to an inadequate response to chemotherapy, or a decision not to undertake more than palliative treatment. Radical treatment of the primary site was radiation alone 41 (79%), resection alone 7 (13%), and resection and radiation 4 (8%). RESULTS: The 5-year survival rates were 9% for all 93 evaluable @entity1 , 16% for 52 @entity1 who received chemotherapy and radical local treatment, 0% for 41 @entity1 who received lesser treatment, 19% for 43 @entity1 with lung metastases alone, and 0% (P = 0.002) for 50 @entity1 with other sites involved. For 60 @entity1 with imaging data, 5-year survivals were 34 and 0% when the maximum transverse diameter of the @entity5 was < 10 cm (N = 20) and > or = 10 cm (N = 40), respectively. CONCLUSIONS: Small @entity5 size and the presence of lung metastases alone were the only significant favorable prognostic factors. Earlier diagnosis will be the basis for better results.

title: Metastatic XXXX / @entity6196 of bone at diagnosis: prognostic factors--a report from Saudi Arabia.

answer: @entity2828 :: (MESH:D012512,Disease) :: ['Ewing sarcoma']


abstract: PURPOSE: Examination of the aetiology, clinical characteristics and the final results for contusion @entity130 of the eyeball. MATERIAL AND METHODS: Retrospective examination of the clinical documentation for 247 @entity1 (260 eyes of which 219 male and 41 female), treated in Emergency Eye Clinic during the period 1994-1996. The @entity1 are separated in groups by their age. DISCUSSION AND RESULTS: Contusion @entity130 are more frequent in @entity1 and @entity1 aged up to 50 years old. The @entity130 are caused by different factors but these having housework and criminal character prevail. The eyeball is with not damaged entity in 225 eyes (86.54%) and with damaged entity in 35 eyes (13.46%). @entity4858 are observed in 11 @entity1 . The clinical characteristics show simultaneous injury of the front protection elements and the eyeball. More often all tissues and areas of the eye are damaged. Serious damages in the area of iris-lens diaphragm, vitreous and retina are observed. The final visual acuity in 178 eyes (68.48%) is between 20/40 and 20/20. CONCLUSION: The contusion @entity130 are more frequent in @entity1 and young @entity1 . The @entity130 caused by factors having housework and criminal character prevail. Usually all tissues and areas of the eye are damaged. The final visual acuity of the most of the eyes is between 20/40 and 20/20.

title: [Contusion eye XXXX : etiology, clinical characteristics and final results].

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'men']

entities_list: @entity4858 :: ('MESH:D005131', 'Disease') :: ['Injuries in both eyes']

answer: @entity130 :: (MESH:D014947,Disease) :: ['traumas']


abstract: OBJECTIVE: Post-movement beta synchronization is an increase in EEG beta power after movement termination. Its characteristics in @entity717 are not well described. @entity191 shows unique clinical, anatomical and biochemical features. In our study we examined the relation between the laterality of @entity400 and size of post-movement beta synchronisation in @entity400 dominant @entity191 . METHODS: In a self-paced movement paradigm we measured movement duration and analyzed EEG power changes at movement-reactive beta frequencies. RESULTS: Movement duration was significantly longer in @entity304 - @entity1 than in controls (0.49 +/- 0.170 s, 0.35 +/- 0.087 s, p = 0.013, Mann-Whitney test). There was no difference between the two hands in the control group (0.36 +/- 0.078 s, 0.34 +/- 0.099 s, p = 0.207, Wilcoxon-test), while @entity304 @entity1 performed longer movement with their left hand (0.52 +/- 0.195 s, 0.46 +/- 0.148 s, p = 0.049, Wilcoxon), unrelated to the side of @entity400 . In controls, post-movement beta synchronisation contralateral to the movement was not significantly different after right and left hand movement (108.1 +/- 68.21% and 92.1 +/- 23.43%, p = 0.78 Wilcoxon). In @entity304 @entity1 post-movement beta synchronisation was significantly smaller contralateral to the @entity717 (36.9 +/- 47.79%, 104.7 +/- 91.42%, p = 0.012, Wilcoxon-test). The post-movement beta synchronisation showed anterior shifting in @entity304 - @entity1 . CONCLUSIONS: In @entity400 dominant @entity191 the asymmetric decrease of post-move beta synchronisation is related to the laterality of @entity400 rather than @entity2845 . Analysis of this phenomena might provide further insight to the pathophysiology of @entity191 .

title: [Electrophysiologic investigation of cerebral cortex in the subtypes of XXXX ].

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['Parkinson']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease", "Tremor dominant Parkinson's disease"]

entities_list: @entity2845 :: ('MESH:D018476', 'Disease') :: ['bradykinesia']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['movement disorders', 'tremulous hand movement']

answer: @entity191 :: (MESH:D010300,Disease) :: ['Parkinson disease']


abstract: AIM OF THE STUDY: To report our experience of total pancreatectomy (TP) in ten @entity1 with mucinous @entity788 (MPT), to discuss pre and peroperative investigations in the management of MPT, and operative, functional and carcinologic results after TP. @entity1 AND METHODS: This retrospective study from January 1985 to January 2001 included ten @entity1 , 5 @entity1 and 5 @entity1 (mean aged: 64 years). Six @entity1 underwent one step TP for @entity5 ( @entity5 ) in 5 cases, and multifocal @entity8940 in one case. Four @entity1 underwent a second step TP for @entity5 recurrence (2 @entity5 , and 2 @entity7157 ) which occurred 12 to 121 months post operatively (mean: 49 months). RESULTS: Post TP @entity6 was controlled by insulinotherapy (3 injections a day), except in one @entity1 who needed insulin administration through a pump. One @entity1 , with @entity7157 , died from @entity5 recurrence 18 months after TP and 140 months after the initial pancreaticoduodenectomy. One @entity1 died from @entity299 34 months postoperatively. The 8 other @entity1 were alive with a mean follow-up of 33 months (range 11-61 months). CONCLUSION: Curative surgery for mucinous @entity5 of the pancreas may require TP, which is indicated preoperatively according to imaging, or intraoperatively following surgical findings and frozen section of the pancreatic margin. Totalization of a previous partial pancreatectomy is mandatory in case of @entity5 persistence or recurrence in the pancreatic remnant. @entity6 can be managed successfully by a specialized team.

title: [Total pancreatectomy for mucinous XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic tumors']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'Postoperative diabetes']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'intraductal papillary mucinous tumor of the pancreas', 'tumors', 'tumoral', 'cancer', 'IPMT']

entities_list: @entity8940 :: ('MESH:D018291', 'Disease') :: ['mucinous cystadenoma']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['heart disease']

entities_list: @entity7157 :: ('MESH:D003536', 'Disease') :: ['cystadenocarcinomas', 'cystadenocarcinoma']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic tumor']


abstract: OBJECTIVES: In the primary treatment of @entity0 , postoperative radiotherapy is performed in high-risk @entity1 after mastectomy and in @entity1 who received breast conserving surgery. In a retrospective analysis, our mono-institutional results of postoperative irradiation have been evaluated. @entity1 AND METHODS: Between 1992 and 1996, 500 @entity1 have been irradiated after surgery for primary @entity0 . Of these, 489 @entity1 had no initial metastases. 89 @entity1 with loco-regional disease had a mastectomy, 400 @entity1 were irradiated after breast conserving surgery. Radiotherapy at the chest wall was performed with 50 Gy and 2 Gy fractions. After microscopically incomplete resection, an electron boost of 10 Gy was given. The ipsilateral lymph nodes were irradiated with 50 Gy when there was extensive lymph node involvement or invasion of @entity5 in the axillary fat tissue. RESULTS: The 5-year local control rate after mastectomy was 97.4% and 91.2% after breast conserving surgery. The only statistically significant risk factor for local failure was microscopically incomplete resection. The corresponding 5-year local control rates for microscopically incomplete and complete resections were 76.4% and 92.7% (p = 0.01). The risk of local relapse was increased with both marginal invasive and marginal DCIS-tissue. 86.6% of local relapses were in the same quadrant. CONCLUSIONS: High-risk @entity1 after mastectomy and @entity1 with breast conserving surgery achieve a high local control rate with postoperative irradiation. After microscopically incomplete resection, there is an increased risk for local relapse.

title: Microscopic residual disease is a risk factor in the primary treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

answer: @entity0 :: (MESH:D001943,Disease) :: ['breast cancer']