abstract: A combined measles-mumps- @entity2462 (MMRV) vaccine is expected to facilitate universal immunization against these 4 diseases. This study was undertaken to synthesize current research findings of the immunogenicity and safety of MMRV in healthy @entity1 .We searched PubMed, Embase, BIOSIS Previews, Web of Science, Cochrane Library, and other databases through September 9, 2014. Eligible randomized controlled trials (RCTs) were selected and collected independently by 2 reviewers. Meta-analysis was conducted using Stata 12.0 and RevMan 5.3.Twenty-four RCTs were included in qualitative synthesis. Nineteen RCTs compared single MMRV dose with measles-mumps- @entity2462 vaccine with or without varicella vaccine (MMR+V/MMR). Similar seroconversion rates of these 4 viruses were found between comparison groups. There were comparable geometric mean titers (GMTs) against @entity20436 viruses between MMRV group and MMR+V/MMR group. MMRV group achieved enhanced immune response to measles component, with GMT ratio of 1.66 (95% confidence interval [CI] 1.48, 1.86; P<0.001) for MMRV versus MMR and 1.62 (95% CI 1.51, 1.70; P<0.001) for MMRV versus MMR+V. Meanwhile, immune response to @entity2462 component in MMRV group was slightly reduced, GMT ratios were 0.81 (95% CI 0.78, 0.85; P<0.001) and 0.79 (95% CI 0.76, 0.83; P<0.001), respectively. Well tolerated safety profiles were demonstrated except higher incidence of @entity221 (relative risks 1.12-1.60) and measles/ @entity2462 -like @entity1910 (relative risks 1.44-1.45) in MMRV groups.MMRV had comparable immunogenicity and overall safety profiles to MMR+V/MMR in healthy @entity1 based on current evidence.

title: Combination Measles-Mumps-Rubella-Varicella Vaccine in Healthy XXXX : A Systematic Review and Meta-analysis of Immunogenicity and Safety.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity2462 :: ('MESH:D012409', 'Disease') :: ['rubella-varicella', 'rubella']

entities_list: @entity20436 :: ('MESH:D009107', 'Disease') :: ['mumps and varicella']

answer: @entity1 :: (9606,Species) :: ['Children']


abstract: The prognostic factors associated with local failure and overall survival and the effect of radiotherapy were determined in 77 @entity1 with localized (extremity and nonextremity) operable soft-tissue @entity242 . There were 52 male and 25 female @entity1 ; median age was 50 years (range: 15-83). Histologic grade of the @entity5 was as follows: low-intermediate grade in 32 cases and high grade in 29 cases. The @entity5 were treated by marginal resection (20 @entity1 ), wide resection (52 @entity1 ), and radical resection (5 @entity1 ). Adjuvant radiotherapy was applied to 50 (65%) @entity1 . The 5-year local recurrence-free survival rate was 70.6%. Treatment with adjuvant radiotherapy and development of @entity3 were the significant prognostic factors associated with local recurrence. Radiotherapy was more effective in @entity1 with @entity5 10 cm or larger, marginally resected, extremity located, and high grades. The overall survival rate was 64.4% at 5 years. Significant adverse prognostic factors were high grade @entity5 , presence of local recurrence, and development of @entity3 in univariate analyses. Development of @entity3 and old age were the only adverse prognostic factors by multivariate analysis. The best 5-year survival rate was obtained in female @entity1 younger than 50 years (90%). The present study demonstrated the importance of adjuvant radiotherapy and development of @entity3 as prognostic factors for local control. Again, development of @entity3 and age were the most important prognostic factors in operable soft-tissue @entity242 .

title: Prognostic factors in localized soft-tissue XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumors', 'tumors']

entities_list: @entity242 :: ('MESH:D012509', 'Disease') :: ['sarcoma', 'sarcomas']

answer: @entity242 :: (MESH:D012509,Disease) :: ['sarcomas']


abstract: @entity22743 , @entity11141 and @entity117 are @entity3785 derivates. They differ in their substitution on the @entity7935 ring and may have different effects on membranes. Red blood cells were used as a prototypical cellular system regarding drug mediated plasma bilayer effects. Established photometric methods sensing tiny changes of red blood cell morphology at rest (red blood cell shape) and at very low shear forces (red blood cell stiffness, red blood cell relaxation time) were applied. The derivative induced effects were detected in a time- and dose-dependent manner. @entity22743 induced a most pronounced echinocytic shape at 5 mM. The shape effect was smaller above as well as below 5 mM. @entity11141 induced echinocytes with increasing concentrations showing a saturation above 10 mM. In contrast, the shape was not affected by @entity117 . All shape changes occurred within 2 min, and were reversible. The above tendencies were in parallel to a slight red blood cell stiffening. The relaxation time continuously increased with increasing concentrations in both @entity22743 and @entity11141 , with @entity22743 always acting stronger. @entity117 again showed no effect. We hypothesize that the observed effects of @entity11141 and @entity22743 are due to their phenolic character mediating a molecular hydrophobicity. According to the bilayer couple hypothesis this would lead to an insertion into the red blood cells outer plasma bilayer leaflet. The extension induced here would cause a positive membrane bending leading to echinocytic shapes and the observed loss of red blood cell fluidity. In contrast, the hydrophilic @entity117 would penetrate and thus not affect the red blood cell plasma membrane.

title: Effects of XXXX derivatives on red blood cell membranes.

entities_list: @entity3785 :: ('MESH:D020156', 'Chemical') :: ['salicylic acid']

entities_list: @entity11141 :: ('MESH:D012980', 'Chemical') :: ['Sodium salicylate', 'sodium salicylate']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['acetylsalicylic acid', 'Acetylsalicylic acid', 'aspirin']

entities_list: @entity22743 :: ('MESH:C031060', 'Chemical') :: ['Salicylamide', 'salicylamide']

answer: @entity3785 :: (MESH:D020156,Chemical) :: ['salicylic acid']


abstract: BACKGROUND: Excessive skin is a side-effect of massive @entity353 . The only evidence-based treatment for @entity272 is plastic surgery. Non-invasive treatments, therefore, need to be evaluated. The aim of this study was to investigate effects of therapeutic ultrasound treatment on excess skin on the upper arms after bariatric surgery. METHOD: Fourteen @entity1 were randomised to receive five treatments, each lasting for 30 minutes with active ultrasound treatment by CellsonicTM (Cellsonic Ltd) on one arm. The other arm served as control. The effect was evaluated objectively by measuring arm volume, circumference, and @entity1736 , and subjectively by a questionnaire where the @entity1 assessed the effect of the treatment and amount and/or discomfort of the excess skin. RESULT: No statistical differences were observed in the objectively measured variables. Some @entity1 reported perceived effects and a majority reported positive experiences of the treatment. No side-effects were reported. CONCLUSION: This study could not find any objectively measured effect of ultrasound treatment on @entity272 after bariatric surgery. However, @entity1 experienced relief of symptoms associated with excess skin, such as @entity158 , looseness, and decreased skin burst, which indicates that ultrasonic treatment of @entity1 with @entity272 should be further investigated.

title: Therapeutic ultrasound treatment for @entity272 on the upper arms due to extensive XXXX after bariatric surgery: A single blind, randomised, controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity272 :: ('MESH:D012871', 'Disease') :: ['excessive skin']

answer: @entity353 :: (MESH:D015431,Disease) :: ['weight loss']


abstract: IMPORTANCE: Problem adaptation therapy (PATH) is a treatment for older adults with @entity308 , @entity73 (from mild @entity73 to moderate @entity303 ), and disability. Antidepressants have limited efficacy in this population and psychosocial interventions are inadequately investigated. OBJECTIVE: To test the efficacy of 12-week PATH vs supportive therapy for @entity73 @entity1 (ST-CI) in reducing @entity308 and disability in 74 older adults with @entity308 , @entity73 , and disability. DESIGN, SETTING, AND @entity1 : A randomized clinical trial at the Weill Cornell Institute of Geriatric Psychiatry from April 1, 2006, to September 31, 2011. Interventions were administered at the @entity1 ' homes. @entity1 included 74 older individuals (age >=  65 years) with @entity308 and @entity73 to the level of moderate @entity303 . They were recruited through collaborating community agencies of Weill Cornell Institute of Geriatric Psychiatry and were randomly assigned to 12 weekly sessions of PATH or ST-CI (14.8% attrition rate). INTERVENTIONS: Home-delivered PATH vs home-delivered ST-CI. Problem adaptation therapy integrates a problem-solving approach with compensatory strategies, environmental adaptations, and caregiver participation to improve @entity1 ' emotion regulation. Supportive therapy for @entity73 @entity1 focuses on expression of affect, understanding, and empathy. MAIN OUTCOMES AND MEASURES: Mixed-effects models for longitudinal data compared the efficacy of PATH with that of ST-CI in reducing @entity308 (Montgomery-Asberg Depression Rating Scale) and disability (World Health Organization Disability Assessment Schedule II) during 12 weeks of treatment. RESULTS: @entity1 in PATH had significantly greater reduction in @entity308 (Cohen d, 0.60; 95% CI, 0.13-1.06; treatment * time, F(1,179) = 8.03; P =   .005) and disability (Cohen d, 0.67; 95% CI, 0.20-1.14; treatment * time, F(1,169) = 14.86; P =   .001) than ST-CI @entity1 during the 12-week period (primary outcomes). Furthermore, PATH @entity1 had significantly greater @entity308 remission rates than ST-CI @entity1 (37.84% vs 13.51%;   (2) = 5.74; P =   .02; number needed to treat = 4.11) (secondary outcome). CONCLUSIONS AND RELEVANCE: Problem adaptation therapy was more efficacious than ST-CI in reducing @entity308 and disability. Problem adaptation therapy may provide relief to a large group of @entity73 older adults who have few treatment options. TRIALS REGISTRATION: Clinicaltrials.gov Identifier: NCT00368940.

title: Problem adaptation therapy for older adults with XXXX and @entity73 : a randomized clinical trial.

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['cognitively impaired', 'cognitive impairment', 'cognitive deficits', 'depressed and cognitively impaired']

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'Participants', 'PARTICIPANTS']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression', 'major depression']

answer: @entity308 :: (MESH:D003866,Disease) :: ['major depression']


abstract: UNASSIGNED: Tectonic  -1 ( @entity68281 ) is an upstream gene involved in embryonic development. The aim of the present study was to investigate the effect of the @entity68281 gene on the viability and @entity263 cells. Lentivirus  -mediated short hairpin RNA (shRNA) was constructed to silence the expression of @entity68281 in PC  -3 and DU145 @entity263 cells. Cell viability and proliferation were measured using @entity98 and colony formation assays, and the distribution of cells in phases of the cell cycle was determined using flow cytometry. Cell migration was detected using a Transwell assay. The results demonstrated that @entity68281 was widely expressed in several @entity1 @entity263 cell lines. Knockdown of the @entity68281 gene by RNA interference markedly suppressed cell viability and colony formation in the PC  -3 and DU145 cell lines. Cell cycle progression was also arrested by @entity68281 silencing. In addition, knockdown of the @entity68281 gene led to the inhibition of cell migration in the two cell lines. These findings confirmed the direct association between the @entity68281 gene and @entity263 growth in  vitro. With further understanding and clinical investigation, this indicates the potential for future development of a novel marker for early detection and gene therapy for @entity263 .

title: Tectonic  -1 contributes to the growth and XXXX cells in  vitro.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'migration of prostate cancer']

answer: @entity263 :: (MESH:D011471,Disease) :: ['migration of prostate cancer']


abstract: @entity794 is the bacterial pathogen which is responsible for approximately 80% of all cases of @entity1 @entity4034 . It can invade and remain within osteoblasts. The fate of intracellular Staph. aureus after the death of the osteoblast has not been documented. We exposed @entity1 osteoblasts to Staph. aureus. After @entity281 , the osteoblasts were either lysed with Triton X-100 or trypsinised. The bacteria released from both the trypsinised and lysed osteoblasts were cultured and counted. Colonies of the recovered bacteria were then introduced to additional cultures of @entity1 osteoblasts. The number of intracellular Staph. aureus recovered from the two techniques was equivalent. Staph. aureus recovered from time zero and 24 hours after @entity281 , followed by lysis/trypsinisation, were capable of invading a second culture of @entity1 osteoblasts. Our findings indicate that dead or dying osteoblasts are capable of releasing viable Staph. aureus and that Staph. aureus released from dying or dead osteoblasts is capable of reinfecting @entity1 osteoblasts in culture.

title: Intracellular @entity794 . A mechanism for the indolence of XXXX .

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity4034 :: ('MESH:D010019', 'Disease') :: ['osteomyelitis']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

answer: @entity4034 :: (MESH:D010019,Disease) :: ['osteomyelitis']


abstract: PURPOSE: Multi-detector row CT (MDCT) is a new noninvasive modality for coronary artery imaging. Using the same MDCT data obtained for coronary artery assessment, left ventricular (LV) volumes such as end-diastolic (ED) and end-systolic (ES) volumes (EDV and @entity5778 , respectively) and ejection fraction (EF) can potentially be assessed when ED and ES datasets are extracted. The purpose of this study was to evaluate the feasibility of MDCT in the assessment of LV volumes. METHODS: Using a pulsating heart phantom (EDV = 143 ml, @entity5778 = 107 ml, @entity64 volume = 36 ml, EF = 25%) and MDCT, EDV and @entity5778 were measured and EF was calculated. Clinical materials consisted of 11 consecutive @entity1 subjects who underwent MDCT. MDCT data were acquired during a single breathhold, using an intravenous injection of contrast medium. Left ventriculography (LVG) was performed in all @entity1 as a gold standard. LV-EF was calculated by measuring @entity5778 and EDV in all @entity1 . RESULTS: In the phantom study, LV volumes were: EDV = 137 ml, @entity5778 = 101 ml, @entity64 volume = 36 ml, and EF = 26%. Close correlations were observed between MDCT values and LVG values (EDV: r = 0.95, @entity5778 : r = 0.98, EF: r = 0.93, p < 0.001). CONCLUSION: MDCT was useful for th e assessment of LV volumes and EF in various @entity1 with CVD.

title: Assessment of left ventricular volumes using multi-detector row computed tomography (MDCT): phantom and XXXX studies.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'human']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: UNASSIGNED: DNA damage response (DDR) consists of both proapoptotic and prosurvival signaling branches. Superiority of each signaling branch determines the outcome of DNA damage: death or allowing the repair. The present authors have previously shown that an increased intracellular level of cAMP disrupts @entity876 -mediated apoptosis in @entity1 pre-B @entity1 cells and inhibition of NF-kB prevents prosurvival effect of cAMP during DNA damage. @entity584 /PKB (protein kinase B) is a general mediator of survival signaling. @entity584 signaling inhibits @entity876 -mediated transcription and apoptosis. The results of present study showed that cAMP disrupted DNA damage/ @entity876 -mediated apoptosis through @entity584 and subsequent NF-kB activation. These results suggested that @entity584 may be found as part of a complex with scaffolding proteins, beta-arrestins and @entity20224 . cAMP disarticulated the complex through binding to @entity20224 compartment. It seems that release of @entity584 protein potentiated DDR activated pro-survival @entity584 in @entity1 cells. Taken together, the present data indicated that regulation of @entity584 signaling may determine the fate of cells exposed to genotoxic stress.

title: PI3K/AKT and Mdm2 activation are associated with inhibitory effect of cAMP increasing agents on DNA damage-induced cell death in XXXX pre-B @entity1 cells.

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND _ AIMS: Serologic profiles after @entity1956 surface antigen (HBsAg) seroclearance in @entity6194 ( @entity6194 ) have not been well-studied. METHODS: We employed a highly sensitive HBsAg (hs-HBsAg) assay (lower detection limit 0.5 mIU/ml), 100 times more sensitive than conventional HBsAg measurements. @entity6194 @entity1 achieving HBsAg seroclearance defined by conventional assays were followed up for serum hs-HBsAg, @entity97 DNA and antibody to HBsAg (anti-HBs) levels at 0 months, 6-12 months and 3-5 years after HBsAg seroclearance. Factors associated with hs-HBsAg detectability were determined. RESULTS: One hundred and nine @entity1 were recruited; 94 (86.2%) were followed up to years 3-5; and 25 @entity1 (22.9%) were on nucleoside analogue therapy for a median duration of 6.0 (range 1.5-12.7) years before HBsAg seroclearance. Detectable hs-HBsAg was noted in 88 (80.7%), 60 (55.0%) and 20 (21.3%) @entity1 at 0 months, 6-12 months and 3-5 years respectively. At years 3-5, genotype B @entity1 , when compared to genotype C @entity1 , had a higher anti-HBs positive rate (63.2% and 41.1% respectively, P = 0.036). Serum anti-HBs positivity, when compared to persistent anti-HBs negativity, was associated with a lower rate of hs-HBsAg detection (7.4% and 40% respectively, P < 0.001). Multivariate analysis showed anti-HBs negativity at years 3-5 to be independently associated with persistently positive hs-HBsAg (P = 0.007, odds ratio 7.1, 95% confidence interval 1.7-29.3). CONCLUSION: Serum hs-HBsAg could detect HBsAg presence in a substantial proportion of @entity6194 after HBsAg seroclearance defined by conventional assays, especially among anti-HBs negative individuals. Serum hs-HBsAg could potentially assist differentiating HBsAg-negative @entity6194 from individuals with only past @entity97 exposure without carrier state.

title: Longitudinal profiles of highly sensitive XXXX surface antigen levels: re-evaluation of HBsAg seroclearance.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6194 :: ('MESH:D019694', 'Disease') :: ['chronic hepatitis B', 'CHB']

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']

answer: @entity1956 :: (MESH:D006509,Disease) :: ['hepatitis B']


abstract: OBJECTIVE: There has been no clear evidence supporting similar chemo-responses for upper and lower @entity189 . METHODS: We conducted a multicenter retrospective cohort study to analyze @entity189 @entity1 who underwent systemic chemotherapy at 17 centers from 2004 to 2010. A total of 298 @entity1 with either @entity150 (N = 151) or upper tract @entity189 (N = 147) were included. Differences in @entity5 location ( @entity150 vs. upper tract @entity189 ) were evaluated in relation to the @entity1 backgrounds and clinical responses to systemic chemotherapy. RESULTS: Overall 216 @entity1 were treated with @entity900 -based chemo-regimens ( @entity136 and @entity900 in 92, or @entity1499 , @entity5713 , @entity632 and @entity900 / @entity1499 , @entity1259 and @entity900 in 124). Among 186 initially metastatic @entity1 , the incidences of lung @entity3 and liver @entity3 were 39.2 and 34.1%, respectively, in upper tract @entity189 @entity1 , and were significantly higher than those with @entity150 (22.4% for lung; 8.4% for liver @entity3 ). Among 112 post-surgical recurrent/metastatic @entity1 , age was significantly higher and estimated glomerular filtration rate at baseline was significantly lower in upper tract @entity189 @entity1 than those with @entity150 . No significant differences were observed in overall clinical response rates for systemic chemotherapy between @entity150 (45.8%) and upper tract @entity189 (38%) in initially metastatic @entity1 or between @entity150 (43.2%) and upper tract @entity189 (44.1%) in post-surgical recurrent/metastatic @entity1 . @entity5 location was not independently associated with @entity5 -specific survival in either initially metastatic or post-surgical recurrent/metastatic @entity189 @entity1 . CONCLUSIONS: No significant difference was observed in response rates of @entity150 and upper tract @entity189 to systemic chemotherapy, suggesting that a similar chemo-regimen can be applied to metastatic @entity189 @entity1 regardless of @entity5 location (upper vs. lower).

title: Do metastatic upper tract @entity189 and XXXX have similar clinical responses to systemic chemotherapy? A Japanese multi-institutional experience.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['adriamycin']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1259 :: ('MESH:D015251', 'Chemical') :: ['epirubicin']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['urothelial carcinoma', 'urothelial carcinomas']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['urothelial carcinoma of the bladder']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

entities_list: @entity5713 :: ('MESH:D014747', 'Chemical') :: ['vinblastine']

answer: @entity150 :: (MESH:D001749,Disease) :: ['bladder carcinoma']


abstract: OBJECTIVE AND IMPORTANCE: We report two cases of massive @entity548 resulting from @entity510 . Both @entity1 had experienced a @entity1756 and were initially moribund. The @entity1 were treated with Guglielmi detachable coiling and then administration of intraventricular @entity1456 (tPA). Rapid clot resolution was demonstrated radiographically in both. Both @entity1 survived and had a meaningful functional neurological recovery. These are the first reported cases of the acute use of intraventricular tPA after Guglielmi detachable coiling treatment for @entity1756 . CLINICAL PRESENTATION: A 59-year-old @entity1 and a 44-year-old @entity1 presented with high-grade @entity510 . Both had had extensive casting of their ventricular systems with blood. INTERVENTION: The @entity1 were treated with Guglielmi detachable coiling @entity715 of the @entity439 and then intraventricular administration of tPA for dissolution of @entity4461 . Both @entity1 survived; one is able to carry out activities of daily living with moderate assistance, and the other is able to communicate with his family. CONCLUSION: This is a novel method to manage @entity1 with high-grade @entity439 with @entity4461 . The tPA reduced the mass effect of the @entity4461 , possibly helping to improve the neurological grade; in addition, the administration of tPA helped keep the external ventricular drains functional, enabling treatment of the acute @entity1276 . The safety of administering tPA after endovascular @entity715 was demonstrated in these two @entity1 . Further investigation is required to determine the applicability of this approach on a broader scale.

title: Use of intraventricular XXXX and Guglielmi detachable coiling for the acute treatment of casted ventricles from cerebral aneurysm hemorrhage: two technical case reports.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'man']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['intraventricular hemorrhage']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity1276 :: ('MESH:D006849', 'Disease') :: ['hydrocephalus']

entities_list: @entity1456 :: ('100128998', 'Gene') :: ['tissue plasminogen activator']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['aneurysms', 'aneurysm']

entities_list: @entity4461 :: ('MESH:D020141', 'Disease') :: ['blood clots', 'massive intraventricular blood clots', 'blood clot']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1756 :: ('MESH:D017542', 'Disease') :: ['ruptured cerebral aneurysm']

answer: @entity1456 :: (100128998,Gene) :: ['tissue plasminogen activator']


abstract: We investigated the intrathecally administrated unbilical cord mesenchymal stem cells (UC-MSCs) by lumbar puncture and assessed the technical difficulties and effects in various neurological conditions. One hundred @entity1 underwent subarachnoid placement of UC-MSCs between December 2006 and May 2010 in the Affiliated Hospital of Medicine. @entity4764 in @entity1 in the form of localization of subarachnoid space, number of attempts, and post-procedural complications were evaluated. Functional evaluation was done using Hauser Ambulation Index (HAI) by the stem cell transplant team on a regular basis. All @entity1 were followed-up for more than 1 yr after the treatment. Clinical symptoms, related biochemical index and photographic examinations were observed regularly. We encountered technical difficulties in 31 @entity1 (31%) in the form of general anesthesia supplementation and difficulty localizing the lumbar space. Side effects ( @entity10 , low-grade fever, @entity1643 and @entity158 ) were observed in 22 (22%) @entity1 , which were treated with symptomatic therapy within 48 h. One year after the treatment, functional indices improved in 47 @entity1 (47%): 12 @entity1 with @entity1566 , 11 @entity1 with @entity306 , 9 @entity1 with @entity131 , 9 @entity1 with post- @entity4798 , 3 @entity1 with @entity164 , and 3 @entity1 with @entity4681 . In conclusion, intrathecal administration of UC-MSCs is a safe and effective way to treat @entity16 . Our encouraging results of intrathecal administration of UC-MSCs indicate the potential of restoration of lost tissue and improvement of function in @entity1 with profound @entity16 and inefficient conventional cure. These data support expanded double-blind, placebo-controlled studies for this treatment modality.

title: Umbilical cord mesenchymal stem cells in XXXX : A clinical study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity4798 :: ('MESH:D020520', 'Disease') :: ['brain infarction syndrome']

entities_list: @entity1643 :: ('MESH:D017116', 'Disease') :: ['low back pain']

entities_list: @entity131 :: ('MESH:D001930', 'Disease') :: ['post-traumatic brain syndrome']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological defects', 'neurological disorders']

entities_list: @entity4681 :: ('MESH:D016472', 'Disease') :: ['motor neuron disease']

entities_list: @entity164 :: ('MESH:D017827', 'Disease') :: ['spinocerebellar ataxias']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['lower limb pain']

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injury']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity4764 :: ('MESH:D051346', 'Disease') :: ['Technical difficulties']

entities_list: @entity306 :: ('MESH:D002547', 'Disease') :: ['cerebral palsy']

answer: @entity16 :: (MESH:D009422,Disease) :: ['neurological disorders']


abstract: OBJECTIVES: To compare anti-inflammatory effect of @entity2993 and @entity8671 in @entity1 of @entity1187 . MATERIALS AND METHODS: The study was a prospective, open-labeled, randomized and single-center study conducted on 100 @entity1 of @entity1187 . @entity1 were assigned to @entity2993 40 mg daily or @entity8671 20 mg daily for 4 weeks. @entity1851 ( @entity1851 ) levels, lipid profiles, erythrocyte sedimentation rate (ESR) and adverse effects were measured at beginning and at the end of 4 weeks. RESULTS: Baseline parameters and clinical profile did not differ between the two groups. @entity1851 levels significantly decreased from beginning to the end of 4 weeks in both @entity2993 and @entity8671 groups (from 35.48 to 23.07 mg/l and from 35.88 to 19.91 mg/l respectively, both P < 0.001). However, there was significant difference between the levels of @entity1851 in @entity1 of the @entity8671 group as compared to the @entity2993 group (19.91    6.32 vs 23.07    7.47, P < 0.05). In addition, both the drugs were associated with a reduction in total @entity165 , LDL levels and ESR at the end of 4 weeks as compared to the beginning (P < 0.001 for all comparisons). CONCLUSION: Both @entity2993 (40 mg) and @entity8671 (20 mg) are effective in decreasing @entity1851 and LDL @entity165 levels even in a short duration of 4 weeks. @entity8671 was found to be more effective in decreasing @entity1851 levels.

title: Comparison of anti-inflammatory effect of @entity2993 with @entity8671 in XXXX of @entity1187 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1187 :: ('MESH:D054058', 'Disease') :: ['acute coronary syndrome']

entities_list: @entity8671 :: ('MESH:C422923', 'Chemical') :: ['rosuvastatin', 'Rosuvastatin']

entities_list: @entity2993 :: ('MESH:C065179', 'Chemical') :: ['atorvastatin']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein', 'CRP']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: HISTORY: A 22 year old @entity1 had noted progressive @entity812 without recognizable urinary abnormalities for five days. INVESTIGATIONS: A urologist had noted increased serum @entity908 (2.1 mg/dl), @entity101 (180/100 mmHg) and microhematuria. A post-renal cause was excluded by excretory urography. An interview revealed that the @entity1 had consumed @entity2072 on weekends since age 19; the acute episode was preceded by a rave party with consumption of a total of 3 g of street quality @entity2072 . DIAGNOSIS AND TREATMENT: Because of microhematuria with a suggestive nephritic urinary sediment, the @entity1 underwent renal biopsy. It showed @entity4295 and @entity4 , but no signs of @entity631 and negative immunohistology. The patient received antihypertensive treatment. This led to rapid reversal of elevated serum @entity1011 and microhematuria was noted, but @entity101 persisted. Currently the @entity1 receives ACE inhibitors. CONCLUSION: Similar to what is seen in the US, @entity2072 use has to be considered in the differential diagnosis of @entity810 with @entity101 .

title: [Acute renal failure and XXXX crisis after a technoparty].

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity4295 :: ('MESH:D007683', 'Disease') :: ['acute tubular necrosis']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity4 :: ('MESH:D004487', 'Disease') :: ['interstitial edema']

entities_list: @entity812 :: ('MESH:D021501', 'Disease') :: ['flank pain']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity631 :: ('MESH:D005921', 'Disease') :: ['glomerulonephritis']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: UNASSIGNED: @entity735 are one of the characteristic adverse events associated with @entity11730 chemotherapy. In this retrospective study, we investigated the frequency and outcome of @entity735 associated with @entity11730 chemotherapy in @entity356 @entity1 . This retrospective study included 75 advanced @entity356 @entity1 who received @entity11730 monotherapy between January 2014 and December 2015. We retrospectively evaluated the frequency, Grade, and @entity735 . @entity735 were observed in 16 @entity1 (21%). The median time of onset was 3(range, 1-8)months. Grade 2 @entity735 , eye discharge, and @entity2024 were reported in 14, 8, and 4 @entity1 , respectively. Artificial tears, @entity11074 eye-drops, and both of these treatments were used in 7, 1, and 8 @entity1 , respectively. Ophthalmologic examination was performed for 3 @entity1 . No delay or reduction of @entity11730 therapy was required for the @entity735 . @entity735 associated with @entity11730 therapy in @entity356 @entity1 did not affect treatment if managed properly using eye drops.

title: [Eye Disorders Associated with @entity11730 Chemotherapy in @entity356 XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['watering eyes', 'treatment of eye disorders', 'eye disorders', 'Eye disorders']

entities_list: @entity11074 :: ('MESH:D005469', 'Chemical') :: ['fluorometholone']

entities_list: @entity2024 :: ('MESH:D003231', 'Disease') :: ['conjunctivitis']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric cancer']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: In a prospective community-based cohort study, we investigated the relationship between @entity79 ( @entity79 ) and regional fat depots in 1474 Korean postmenopausal @entity1 . @entity79 was positively related with subcutaneous fat and negatively related with visceral fat. INTRODUCTION: The effect of fat distribution (visceral/subcutaneous) on bone quality or microarchitecture has rarely been investigated due to measurement difficulty. We aimed to investigate the relationship between @entity79 reflecting bone microarchitecture and regional fat depots in Korean @entity1 . METHODS: Cross-sectional data evaluation was made from subjects participating in an ongoing prospective community-based cohort study since 2001. A total of 1474 postmenopausal @entity1 in the Ansung cohort were analyzed. Regional body fat mass, bone mineral density (BMD) at the lumbar spine, and total hip and lumbar spine @entity79 were measured by dual energy X-ray absorptiometry (DXA). RESULTS: In an age-adjusted partial correlation analysis, @entity79 was not associated with total fat mass, but negatively associated with trunk fat mass. However, @entity79 was positively related with leg (r   =   0.102, P   <   0.05) and gynoid fat mass (r   =   0.086, P   <   0.05) and negatively related with android fat mass (r   =   -0.106; P   <   0.05). In linear regression models controlling age, BMI, and physical activity, android fat was inversely associated with @entity79 (b   =   -0.595, P   <   0.001), whereas gynoid fat was positively associated with @entity79 (b   =   0.216, P   <   0.001). Lumbar spine and total hip BMDs revealed positive associations with total and all regional fat depots regardless of fat distribution. CONCLUSION: Our findings suggest that relatively large visceral fat and small subcutaneous fat may have a detrimental effect on @entity79 , a bone microarchitecture index.

title: Regional body fat depots differently affect bone microarchitecture in postmenopausal Korean XXXX .

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['trabecular bone score', 'TBS']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: The results of a longterm prospective follow-up study after the 'Double @entity1912 Scheie filtering operation are presented. Fifty-two eyes of 47 @entity1 with @entity725 ( @entity725 ) were operated; after ten years 29 eyes of 24 @entity1 could be examined. Twenty @entity1 (43%) had died, in three follow-up was incomplete. The two and four year results have been published earlier. In the 29 eyes the mean intraocular pressure (IOP) without medical therapy rose from 15.8 mm Hg at five years to 16.3 mm Hg at ten years (not significant). Additional medical or surgical treatment was necessary in 35% of the eyes. Diurnal variation and outflow facility remained stable. During the ten years 13 eyes showed some @entity227 . Nearly all clinically important deterioration occurred within five years after the operation. @entity231 progression was noticed in 45% (13 of 29); four times a lens extraction was performed (13%). Complete success of the operation, as judged by stable visual fields and IOP levels at or under 21 mm Hg without additional medical or surgical therapy was reached in 13 of 20 eyes (45%). Based on IOP alone the success rate was 62% without and 93% with additional treatment.

title: Ten year prospective follow-up of a glaucoma operation. The Double @entity1912 Scheie in XXXX .

entities_list: @entity725 :: ('MESH:C562750', 'Disease') :: ['POAG', 'primary open angle glaucoma']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['deterioration of visual fields']

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['Cataract']

answer: @entity725 :: (MESH:C562750,Disease) :: ['primary open angle glaucoma']


abstract: BACKGROUND: Although @entity2953 ( @entity2953 ) are a global health problem affecting every region of the world, the higher prevalence and mortality rate of @entity2953 in developing countries of the world, like Nigeria, make them serious public health issues in this region. OBJECTIVE: The aim of this study is to assess the knowledge and perception of young adults in Nigeria on the role of condom (both male and female condoms) as a preventive measure against @entity2953 during heterosexual and homosexual intercourse. MATERIALS AND METHODS: Data was collected from @entity1 selected from the northern and southern Nigeria using self-administered questionnaire specifically designed for this study. RESULTS: Knowledge of condom efficacy in STI prevention was satisfactory. However, knowledge and practice of the correct use of condom was poor. Only 47.1% of the 102 @entity1 in this study reported correct condom use of wearing condoms before staring intercourse and removing condoms after ejaculation. As a strategy to include the experiences, knowledge and perception of @entity1 who have sex with @entity1 , this study asked the question on condom use during anal sex. Only 24.4% of the male @entity1 indicated they have never had anal sex while for females, the percentage was more than half (53.5%). Condom use during anal sex was low with only 20.6% of @entity1 reporting condom use during anal sex. Negative perceptions about condom use - such as that condom use promotes sexual promiscuity, and not using condoms with steady sexual partners - were significant in this study. Also, condom use errors were common in this study. CONCLUSION: There is a wide gap in knowledge of correct condom use in this population. There is need for interventions that address the issue of condom use during anal and same-sex sexual intercourse in this population.

title: Knowledge and perception of young adults in Nigeria on effectiveness of condom use in prevention of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'participants']

entities_list: @entity2953 :: ('MESH:D012749', 'Disease') :: ['sexually transmitted infections', 'STIs']

answer: @entity2953 :: (MESH:D012749,Disease) :: ['sexually transmitted infections']


abstract: 1. @entity141 - @entity70145 -dependent protein kinase II (CaMK) and a @entity70145 ( @entity70145 )-binding 'IQ' domain (IQ) are both implicated in @entity141 -dependent regulation of L-type @entity141 current (I( @entity9495 )). We used an IQ-mimetic peptide (IQmp), under conditions in which CaMK activity was controlled, to test the relationship between these @entity70145 -activated signalling elements in the regulation of L-type @entity141 channels (LTCCs) and I( @entity9495 ) in @entity95 ventricular myocytes. 2. A specific CaMK inhibitory peptide nearly abolished I( @entity9495 ) facilitation, but the facilitation was 'rescued' by cell dialysis with IQmp. 3. IQmp significantly enhanced I( @entity9495 ) facilitation and slowed the fast component of I( @entity9495 ) inactivation, compared with an inactive control peptide. Neither effect could be elicited by a more avid @entity70145 -binding peptide, suggesting that generalized @entity70145 buffering did not account for the effects of IQmp. 4. I( @entity9495 ) facilitation was abolished and the fast component of inactivation eliminated by @entity8452 , @entity5834 or @entity2426 , suggesting that the sarcoplasmic reticulum (SR) is an important source of @entity141 for I( @entity9495 ) facilitation and inactivation. IQmp did not restore I( @entity9495 ) facilitation under these conditions. 5. Engineered @entity141 -independent CaMK and IQmp each markedly increased LTCC open probability (P(o)) in excised cell membrane patches. The LTCC P(o) increases with CaMK and IQmp were non-additive, suggesting that CaMK and IQmp are components of a shared signalling pathway. 6. Both CaMK and IQmp induced a modal gating shift in LTCCs that favoured prolonged openings, indicating that CaMK and IQmp affect LTCCs through a common biophysical mechanism. 7. These findings support the hypothesis that CaMK is required for physiological I( @entity9495 ) facilitation in cardiac myocytes. Both CaMK and IQmp were able to induce a modal gating shift in LTCCs, suggesting that each of these signalling elements is important for @entity141 - @entity70145 -dependent LTCC facilitation in cardiac myocytes.

title: @entity70145 kinase and a @entity70145 -binding 'IQ' domain facilitate L-type XXXX current in @entity95 ventricular myocytes by a common mechanism.

entities_list: @entity2426 :: ('MESH:D019284', 'Chemical') :: ['thapsigargin']

entities_list: @entity8452 :: ('MESH:D012433', 'Chemical') :: ['ryanodine']

entities_list: @entity5834 :: ('MESH:D002110', 'Chemical') :: ['caffeine']

answer: @entity141 :: (CHEBI:29108,Chemical) :: ['Ca2+']


abstract: BACKGROUND/PURPOSE: The intussusception-type antireflux valve is a mechanism introduced by Nakajo, who reported the results of his initial 17 cases in 1990. This report summarizes our further experience with new @entity1 , together with follow-up results of the cases previously reported by Nakajo. METHODS: In total, 46 new @entity1 who had @entity2876 underwent portoenterostomy at the authors' two units. The authors hoped to construct the intussuscepted antireflux valve in the Roux-en-Y loop, whenever possible, at the time of hepatic portoenterostomy. RESULTS: Among the 46 @entity1 , one case each was found to be too young or too old to have the valve constructed during the surgery. In another case, the Roux-en-Y loop became too short after repeated revisions of the portoenterostomy. In another @entity1 , the valve was first constructed but later removed because of jejunal perforation near the valve. In the last @entity1 , the valve was not constructed for unspecified reasons. The authors constructed the antireflux valve in 42 @entity1 , but it was maintained in 41. In one case, the valve truly prevented reflux of the intestinal juice during an episode of @entity1321 . The valve was found to be incompetent in one @entity1 5 years after the initial surgery. CONCLUSION: The incidence of @entity255 was high in @entity1 with @entity384 of the intrahepatic bile ducts, and low in those without it.

title: Further experience with the antireflux valve to prevent XXXX in @entity2876 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['postoperative cystic dilatation']

entities_list: @entity1321 :: ('MESH:D007415', 'Disease') :: ['intestinal obstruction']

entities_list: @entity2876 :: ('MESH:D001656', 'Disease') :: ['biliary atresia']

entities_list: @entity255 :: ('MESH:D002761', 'Disease') :: ['cholangitis']

answer: @entity255 :: (MESH:D002761,Disease) :: ['ascending cholangitis']


abstract: OBJECTIVES: To estimate the proportion of @entity1 with @entity164 2 @entity6 who were eligible for @entity1780 treatment per American @entity6 Association (ADA) recommendations and the proportion who were actually prescribed a @entity1780 in US clinical practice. Factors associated with receiving a @entity1780 prescription were also determined. METHODS: @entity1 >=  25 years diagnosed with @entity164 2 @entity6 or had received prescriptions for antihyperglycemic agents between 7/2006 and 6/2008 were identified within a large electronic medical record database. Eligibility for @entity1780 therapy was determined according to 2008 ADA recommendations. @entity1780 use was assessed based on prescription records during a 12-month follow-up period. An adjusted logistic regression analysis was performed to estimate the likelihood of @entity1780 use in relation to selected baseline characteristics. RESULTS: Of the 125,464 @entity1 identified, 98.5% were eligible for @entity1780 therapy. Only 62.9% received a @entity1780 prescription during follow-up period. In an adjusted logistic regression, factors associated with increased likelihood of @entity1780 use were older age, male gender, smoking, history of @entity65 , and receiving an antihyperglycemic, antihypertensive, or anticoagulant prescription at baseline (all p < 0.05). LIMITATIONS: Of the @entity1 who did not receive @entity1780 during follow-up, 13% of them were previously on a @entity1780 during the baseline period. The reasons for discontinuing therapy are not known. It cannot be excluded that some of these @entity1 were intolerant or had contraindications to @entity1780 . The data on prescription dispensing and compliance were not recorded. CONCLUSIONS: Nearly all @entity1 with @entity164 2 @entity6 were eligible for @entity1780 therapy, but less than two-thirds received @entity1780 therapy in US clinical practice. Efforts to minimize this gap are warranted.

title: Underutilization of statins in @entity1 with @entity164 2 XXXX in US clinical practice: a retrospective cohort study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes', 'diabetes']

entities_list: @entity1780 :: ('CHEBI:35664', 'Chemical') :: ['statin', 'Statin']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular conditions']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: BACKGROUND: Cognitive behavioural therapy for @entity1 with @entity161 is a psychotherapeutic approach that establishes links between thoughts, emotions and behaviours and challenges dysfunctional thoughts. There is some evidence to suggest that cognitive behavioural therapy for @entity1 with @entity716 (CBTp) might be an effective treatment for @entity1 with @entity161 . There are however, limitations in its provision due to available resource and training issues. One way to tackle this issue might be to offer a brief version of CBTp. OBJECTIVES: To review the effects of brief CBTp (6 to 10 regular sessions given in less than 4 months and using a manual) for @entity1 with @entity161 compared with standard CBTp (12 to 20 regular sessions given in 4 to 6 months and using a manual). SEARCH METHODS: We searched the Cochrane @entity161 Group's Trials Register (August 21, 2013 and August 26, 2015) which is based on regular searches of CINAHL, BIOSIS, AMED, EMBASE, PubMed, MEDLINE, PsycINFO and registries of Clinical Trials. There are no language, date, document type, or publication status limitations for inclusion of records in the register. We inspected all references of the selected articles for further relevant trials. We also contacted experts in the field regarding brief CBTp studies. SELECTION CRITERIA: Randomised controlled trials involving adults with @entity161 or @entity74 , comparing brief cognitive behavioural therapy for @entity1 with @entity716 versus standard CBTp. DATA COLLECTION AND ANALYSIS: Two review authors independently screened and assessed studies for inclusion using pre-specified inclusion criteria. MAIN RESULTS: We found only seven studies which used a brief version of CBTp, but no study compared brief CBTp with CBTp of standard duration. No studies could be included. AUTHORS' CONCLUSIONS: Currently there is no literature available to compare brief with standard CBTp for @entity1 with @entity161 . We cannot, therefore, conclude whether brief CBTp is as effective, less effective or even more effective than standard courses of the same therapy. This lack of evidence for brief CBTp has serious implications for research and practice. Well planned, conducted and reported randomised trials are indicated.

title: Cognitive behavioural therapy (brief versus standard duration) for XXXX .

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['related disorders']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: Rhizobium tropici forms @entity1568 -fixing nodules on the roots of the common bean ( @entity11297 ). Like other legume-Rhizobium symbioses, the bean-R. tropici association is sensitive to the availability of @entity1391 (P(i)). To better understand @entity3151 movement between the bacteroid and the host plant, P(i) transport was characterized in R. tropici. We observed two P(i) transport systems, a high-affinity system and a low-affinity system. To facilitate the study of these transport systems, a Tn5B22 transposon mutant lacking expression of the high-affinity transport system was isolated and used to characterize the low-affinity transport system in the absence of the high-affinity system. The K(m) and V(max) values for the low-affinity system were estimated to be 34 +/- 3 microM P(i) and 118 +/- 8 nmol of P(i) x min(-1) x mg (dry weight) of cells(-1), respectively, and the K(m) and V(max) values for the high-affinity system were 0.45 +/- 0.01 microM P(i) and 86 +/- 5 nmol of P(i) x min(-1) x mg (dry weight) of cells(-1), respectively. Both systems were inducible by P(i) starvation and were also shock sensitive, which indicated that there was a periplasmic binding-protein component. Neither transport system appeared to be sensitive to the proton motive force dissipator @entity6320 , but P(i) transport through both systems was eliminated by the ATPase inhibitor @entity18040 ; the P(i) transport rate was correlated with the intracellular @entity855 concentration. Also, P(i) movement through both systems appeared to be unidirectional, as no efflux or exchange was observed with either the wild-type strain or the mutant. These properties suggest that both P(i) transport systems are ABC type systems. Analysis of the transposon insertion site revealed that the interrupted gene exhibited a high level of homology with kdpE, which in several bacteria encodes a cytoplasmic response regulator that governs responses to low @entity972 contents and/or changes in medium osmolarity.

title: Characterization of two inducible XXXX transport systems in Rhizobium tropici.

entities_list: @entity11297 :: ('3885', 'Species') :: ['Phaseolus vulgaris']

entities_list: @entity1568 :: ('MESH:D009584', 'Chemical') :: ['nitrogen']

entities_list: @entity6320 :: ('MESH:D002258', 'Chemical') :: ['carbonyl cyanide m-chlorophenylhydrazone']

entities_list: @entity18040 :: ('CHEBI:53090', 'Chemical') :: ["N,N'-dicyclohexylcarbodiimide"]

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity3151 :: ('MESH:D010758', 'Chemical') :: ['phosphorus']

answer: @entity1391 :: (CHEBI:26020,Chemical) :: ['phosphate']


abstract: BACKGROUND: The @entity1577 ( @entity1577 ) Foundation recommends @entity1 attend clinic >= 4 times per year with 4 respiratory cultures and 2 pulmonary function tests (PFTs). However, nationally only 57.4% of @entity1 met these guidelines in 2012. We used a quality improvement program with a goal of 75% of our @entity1 meeting this care guideline by 2012. METHODS: A 2-stage program was started in 2011. Stage 1: education of @entity1 /caregivers on importance of quarterly visits. Stage 2: quarterly tracking system of @entity1 appointments. Data on clinic visits, respiratory cultures, and PFTs were collected from the @entity1577 registry from January 2009 through December 2013. Statistical process control charts were used to track improvements. RESULTS: The average number of clinic visits increased significantly from 4.6    2.3 in 2009 to 6.3    4.6 in 2013 (P < .0001). The percentage of @entity1 ages 6 through 18 completing a clinic visit, PFT, and respiratory culture per quarter increased significantly from 76.2% during 2009 to 86.4% in 2013. The percentage of @entity1 completing >= 4 clinic visits with 4 respiratory cultures and 2 PFTs improved significantly from 47.5% in 2009 to 71.0% in 2013 (P < .0001). CONCLUSIONS: A tracking system of @entity1 appointments significantly improved adherence to the care guidelines better than education alone. The multiple-stage quality improvement program we implemented may be modifiable and able to be integrated in other @entity1577 centers or other multiple disciplinary @entity102 care centers.

title: Improvements in XXXX Quarterly Visits, Lung Function Tests, and Respiratory Cultures.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1577 :: ('MESH:D003550', 'Disease') :: ['CF', 'Cystic Fibrosis']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic illness']

answer: @entity1577 :: (MESH:D003550,Disease) :: ['Cystic Fibrosis']


abstract: OBJECTIVE: To study the prevalence of Barrett esophagus (BE) ( @entity356 ) in adolescents treated for @entity1152 ( @entity1152 ). SUMMARY OF BACKGROUND DATA: @entity1152 @entity1 are at high risk of BE. METHODS: This multicenter prospective study included @entity1152 @entity1 aged 15 to 19 years. All eligible @entity1 were proposed an @entity1729 with multistaged esophageal biopsies under general anesthesia. Histological suspicion of @entity4648 was confirmed centrally. RESULTS: One hundred twenty @entity1 [mean age, 16.5 years (  1.4)] were included; 70% had been treated for @entity354 ( @entity354 ) during infancy. At evaluation, 8% were undernourished, 41% had received antireflux surgery, and 41% presented with @entity354 symptoms, although only 28% were receiving medical treatment. @entity2910 was found at endoscopy in 34% and confirmed at histology in 67%. BE was suspected after endoscopy in 37% and was confirmed by histology for 43% of @entity1 (50 gastric and 1 intestinal @entity4648 ). No endoscopic or histological anomalies were found at the @entity254 site. BE was not significantly related to clinical symptoms. In multivariate analysis, BE was associated with @entity1152 without @entity292 (P = 0.03), previous multiple antireflux surgery (P = 0.04), esophageal dilation (P = 0.04), suspicion of BE at endoscopy (P < 0.001), and histological @entity2910 (P = 0.02). CONCLUSIONS: @entity1 with @entity1152 are at high risk of persistent @entity354 and BE. The development of BE is related to @entity354 history. Long-term systematic follow-up of the esophageal mucosa including multistaged biopsies is required, even in asymptomatic @entity1 . (NCT02495051).

title: Prevalence of Barrett Esophagus in Adolescents and Young Adults With XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1152 :: ('MESH:D004933', 'Disease') :: ['esophageal atresia', 'EA']

entities_list: @entity2910 :: ('MESH:D004941', 'Disease') :: ['esophagitis', 'Esophagitis']

entities_list: @entity254 :: ('MESH:C563598', 'Disease') :: ['anastomosis']

entities_list: @entity4648 :: ('MESH:D008679', 'Disease') :: ['metaplasia']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['upper endoscopy']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease', 'GERD']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric and/or intestinal metaplasia']

answer: @entity1152 :: (MESH:D004933,Disease) :: ['Esophageal Atresia']


abstract: This study was undertaken to (1) determine the incidence of articular @entity1844 in @entity1 with instability of the glenohumeral joint, (2) determine whether recurrent dislocations increased the risk of @entity16 , and (3) correlate these injuries with postoperative clinical outcomes. A cohort was identified of consecutive @entity1 who underwent diagnostic magnetic resonance imaging and shoulder arthroscopy for glenohumeral instability with documented dislocation or subluxation between 1997 and 2006 at a single institution. @entity1 with moderate or severe @entity571 were excluded. Arthroscopic findings were recorded, including lesion location and Outerbridge grade. The American Shoulder and Elbow Surgeons Standardized Shoulder Assessment Form (ASES) was used to assess outcome in 61 @entity1 who were available for follow-up. Outcomes were compared between shoulders with and without @entity75 . A total of 87 shoulders (83 @entity1 ) met the inclusion criteria, with 69 (83%) @entity1 and 14 (17%) @entity1 . Mean age was 26.1 years (range, 18-64 years), and mean follow-up was 36 months (range, 33-39 months). @entity1844 were found in 56 shoulders (64%). Previously documented shoulder dislocation requiring closed reduction (P=.046) and the number of discrete dislocations (P=.032) were significant for @entity130 . A greater number of dislocations was associated with higher-grade lesions of the glenohumeral joint (P<.001). Overall, mean ASES score was 89.6 (range, 37-100). In @entity1 with an articular cartilage lesion, mean ASES score was 90.4 (range, 58-100) compared with 88.1 (range, 37-100) in those without this injury (P=.75). Although clinical outcomes were not significantly affected, further investigation is warranted to establish a relationship between these injuries and longer-term outcomes. [Orthopedics. 2015; 38(11):e965-e969.].

title: The Effect of XXXX After Arthroscopic Stabilization for Shoulder Instability.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'men']

entities_list: @entity1844 :: ('MESH:D002357', 'Disease') :: ['Cartilage injuries', 'cartilage injuries']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['articular lesions']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['articular damage']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['glenoid injury']

answer: @entity1844 :: (MESH:D002357,Disease) :: ['Cartilage Injury']


abstract: The increased knowledge regarding @entity281 in @entity213 ( @entity213 ) has unexpectedly contributed to several uncertainties related to i) prevalence diversities depending on @entity5 site and geographical origin of the @entity1 , ii) proportion of @entity5 among HPV-DNA-positive cases, and iii) identification of @entity1 with HPV-attributed survival benefit. To investigate this heterogeneity, we analysed 307 @entity213 cases (tonsillar, n=135; non-tonsillar, n=172) from eight health care centers mostly from Northern Germany and determined HPV-DNA/mRNA and @entity986 -status and combined results with the @entity1 outcome. Overall HPV-DNA prevalence rate was 23.5% (72/307); attributed to: 43.7% (59/135) and 7.6% (13/172) tonsillar and non-tonsillar cases, respectively. Among these, 96.6% tonsillar and 38.5% non- @entity5326 were HPV-mRNA-positive. Although the study cohort was composed of @entity1 from regions of rather close proximity, prevalence rates showed diversities of up to 40% in @entity213 subsite analysis with the lowest prevalence for @entity5326 in metropolitan areas (22.2%) vs. 50.9% in rural areas. Survival analysis identified @entity986 alone as strongest predictor, followed by HPV-DNA-status alone or in combination with @entity986 . This survival benefit was shown for tonsillar and non-tonsillar cases. Smoking significantly correlated with HPV-status, however, it does not influence survival when stratified for HPV. In conclusion, the data emphasize the urge for further data on @entity281 in @entity213 to, e.g. clarify to what extent survival benefits of @entity986 -positive @entity1 are truly attributed to @entity281 .

title: Geographical and anatomical influences on human papillomavirus prevalence diversity in XXXX in Germany.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['HPV-driven tumours', 'tumour']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['HPV-infections', 'HPV-infection']

entities_list: @entity5326 :: ('MESH:D014067', 'Disease') :: ['tonsillar SCC']

entities_list: @entity213 :: ('MESH:C535575', 'Disease') :: ['head and neck squamous cell carcinoma', 'HNSCC']

answer: @entity213 :: (MESH:C535575,Disease) :: ['head and neck squamous cell carcinoma']


abstract: BACKGROUND: The purpose of this study was to determine the best tolerated and efficacious dose of @entity1206 given once or twice in 3-week cycles in combination with @entity1499 and @entity1487 (VMF). @entity1 AND METHODS: @entity1206 40 mg/m(2) was given as follows: 20 mg/m(2) on days 1 and 8 (group 1); 30 mg/m(2) on day 1 and 10 mg/m(2) on day 8 (group 2); or 40 mg/m(2) on day 1 (not exeeding 60 mg/m(2)) (group 3). The @entity1499 dose was 40 mg/m(2) on day 1 and the @entity1487 dose 600 mg/m(2) on days 1 and 8. Thirty @entity1 with evaluable @entity3 were randomly allocated to the groups (first step). The second step was to exclude the worst tolerated regimen and then to expand the study to 60 @entity1 . Thus, group 1 had 26 @entity1 , group 2 had 24 @entity1 and group 3 had 10 @entity1 . RESULTS: World Health Organization (WHO) grade 3 hematological @entity137 occurred in 23%, 36% and 50% of @entity1 and grade 4 in 39%, 32% and 50% of @entity1 in groups 1, 2 and 3, respectively; grade 3 @entity281 were observed in 15%, 9% and 10% of @entity1 in groups 1, 2 and 3, and grade 4 @entity281 in 5% and 10% of @entity1 in groups 2 and 3, respectively. Nonhematological @entity137 included a mild to moderate @entity2359 manifesting as @entity1142 , abdominal colics and @entity925 in the majority of @entity1 . One @entity1 in group 3 had serious @entity410 after @entity1206 administration; she also developed @entity1398 ; all symptoms were reversible. No @entity1 died from side-effects. The objective response rates were 50%, 55% and 44% for groups 1, 2 and 3, respectively. Median time to progression was 7, 10 and 8 months and median survival time was 26, 23 and 16 months in groups 1, 2 and 3, respectively. CONCLUSION: VMF regimens where the @entity1206 dose (40 mg/m(2)) is divided (20 + 20 mg/m(2) and 30 + 10 mg/m(2)) between days 1 and 8 of a 3-week cycle are equally well tolerated and the efficacy is comparable to other modern first line regimens used in the treatment of metastatic @entity0 .

title: @entity1206 , XXXX and @entity1487 (VMF) as first-line therapy in metastatic @entity0 : a randomized phase II trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['convulsions']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

entities_list: @entity1206 :: ('MESH:C030852', 'Chemical') :: ['vinorelbine', 'Vinorelbine']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenic sepsis']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity1142 :: ('MESH:D003248', 'Disease') :: ['constipation']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['fluorouracil']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: BACKGROUND: A prospective 1-year study was conducted to assess the frequency, clinical spectrum, histologic description, and follow-up of @entity7592 unrelated to ingestion of caustic or corrosive agents. METHODS: The diagnosis of @entity7592 was based on a diffusely black esophagus at endoscopy and typical histologic features of @entity39 . Ingestion of caustic and corrosive agents was excluded in all @entity1 . Medical history, associated diseases, and clinical symptoms were recorded for each @entity1 . Nutritional status was evaluated based on clinical and biochemical parameters. Treatment included short-term parenteral nutrition and intravenous administration of a pump proton inhibitor. A second endoscopy was performed when possible at 2 weeks after presentation to assess regression of @entity7592 . RESULTS: Among 3900 @entity1 who underwent EGD, 8 (0.2%) with @entity7592 were identified. Nutritional status was poor for 6 @entity1 . Complete resolution of @entity7592 without further recurrence was observed in 4. No esophageal strictures appeared during follow-up. Four @entity1 died, but no death was directly related to @entity7592 . CONCLUSION: Acute @entity39 is not as infrequent an endoscopic finding as has been reported. Acute @entity39 appears to be associated with poor general health status and is not a purely local phenomenon.

title: Acute XXXX : a 1-year prospective study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity7592 :: ('MESH:D015882', 'Disease') :: ['acute esophageal necrosis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['esophageal necrosis', 'diffuse mucosal and submucosal necrosis']

answer: @entity39 :: (MESH:D009336,Disease) :: ['esophageal necrosis']


abstract: OBJECTIVE: To investigate predictors of @entity4806 in @entity3004 . DESIGN: Cross-sectional study. Height, weight and waist circumference were measured using standard procedures. Overweight and @entity28 in adolescents aged 10-17 years were assessed using the International Obesity Taskforce cut-offs, while the WHO adult cut-offs were used for @entity1 aged 18-20 years. Waist-to-height ratio of >0.5 @entity1144 in those at Tanner stages 3-5. Linear and logistic regression analysis was used to evaluate risk factors. SETTING: Agincourt sub-district, @entity3004 . SUBJECTS: @entity1 (n 1848) were aged 10-20 years. RESULTS: Combined overweight and @entity28 was higher in @entity1 (15 %) than @entity1 (4 %), as was @entity1144 (15 % and 2 %, respectively). With regard to overweight/ @entity28 , fourfold higher odds were observed for @entity1 and twofold higher odds were observed for @entity1 from households with the highest socio-economic status (SES). The odds for overweight/ @entity28 were 40 % lower if the household head had not completed secondary level education. For @entity1144 , the odds increased 10 % for each unit increase in age; @entity1 had sevenfold higher odds v. @entity1 ; post-pubertal @entity1 had threefold higher odds v. pubertal @entity1 ; those with older mothers aged 50+ years had twofold higher odds v. those whose mothers were aged 35-49 years; those in highest SES households had twofold higher odds v. those in lowest SES households. CONCLUSIONS: In @entity3004 , adolescent females are most at risk of @entity28 which increases with age and appears to be associated with higher SES. To intervene effectively, it is essential to understand how household factors influence food choice, diet and exercise.

title: Predictors of adolescent weight status and XXXX in @entity3004 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants', 'girls', 'boys']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity4806 :: ('MESH:D063766', 'Disease') :: ['adolescent obesity']

entities_list: @entity1144 :: ('MESH:D056128', 'Disease') :: ['defined central obesity', 'central obesity']

entities_list: @entity3004 :: ('MESH:C537904', 'Disease') :: ['rural South Africa']

answer: @entity1144 :: (MESH:D056128,Disease) :: ['central obesity']


abstract: UNASSIGNED: Migrant Chinese populations in Western countries have a high prevalence of @entity6194 but often experience poor access to healthcare and late diagnosis. This systematic review aimed to identify obstacles and supports to timely and appropriate health service use among these populations. Systematic searches resulted in 48 relevant studies published between 1996 and 2015. Data extraction and synthesis were informed by models of healthcare access that highlight the interplay of @entity1 , provider and health system factors. There was strong consistent evidence of low levels of knowledge among @entity1 and community members; but interventions that were primarily focused on increasing knowledge had only modest positive effects on testing and/or vaccination. There was strong consistent evidence that Chinese migrants tend to misunderstand the need for healthcare for @entity1956 and have low satisfaction with services. Stigma was consistently associated with @entity1956 and there was weak but consistent evidence of stigma acting as a barrier to care. However, available evidence on the effects of providing culturally appropriate services for @entity1956 on increasing uptake is limited. There was strong consistent evidence that health professionals miss opportunities for testing and vaccination. Practitioner education interventions may be important but evidence of effectiveness is limited. A simple prompt in @entity1 records for primary care physicians improved the uptake of testing; and a dedicated service increased targeted vaccination coverage for new-borns. Further development and more rigorous evaluation of more holistic approaches that address @entity1 , provider and system obstacles are needed. This article is protected by copyright. All rights reserved.

title: Improving access to health care for XXXX among migrant Chinese populations: a systematic mixed methods review of barriers and enablers.

entities_list: @entity6194 :: ('MESH:D019694', 'Disease') :: ['chronic hepatitis B']

entities_list: @entity1956 :: ('MESH:D006509', 'Disease') :: ['hepatitis B']

answer: @entity6194 :: (MESH:D019694,Disease) :: ['chronic hepatitis B']


abstract: UNASSIGNED: We performed a simulation study to evaluate the performances of an @entity154 detection algorithm considered in the frame of an automated surveillance system of @entity291 mortality. The method consisted in a combination of temporal regression and spatial cluster detection which allows identifying, for a given week, clusters of spatial units showing an excess of @entity204 in comparison with their own historical fluctuations. First, we simulated 1,000 outbreaks of a disease causing extra @entity204 in the French @entity291 population (about 200,000 herds and 20 million @entity291 ) according to a model mimicking the spreading patterns of an infectious disease and injected these disease-related extra @entity204 in an authentic mortality dataset, spanning from January 2005 to January 2010. Second, we applied our algorithm on each of the 1,000 semi-synthetic datasets to identify clusters of spatial units showing an excess of @entity204 considering their own historical fluctuations. Third, we verified if the clusters identified by the algorithm did contain simulated extra @entity204 in order to evaluate the ability of the algorithm to identify unusual mortality clusters caused by an outbreak. Among the 1,000 simulations, the median duration of simulated outbreaks was 8 weeks, with a median number of 5,627 simulated @entity204 and 441 infected herds. Within the 12-week trial period, 73% of the simulated outbreaks were detected, with a median timeliness of 1 week, and a mean of 1.4 weeks. The proportion of outbreak weeks flagged by an alarm was 61% (i.e. sensitivity) whereas one in three alarms was a true alarm (i.e. positive predictive value). The performances of the detection algorithm were evaluated for alternative combination of epidemiologic parameters. The results of our study confirmed that in certain conditions automated algorithms could help identifying abnormal @entity291 mortality increases possibly related to unidentified health events.

title: Simulation-Based Evaluation of the Performances of an Algorithm for Detecting Abnormal Disease-Related Features in XXXX Mortality Records.

answer: @entity291 :: (9913,Species) :: ['Cattle']


abstract: OBJECTIVE: This study aimed to describe the clinical and histopathologic findings in four @entity1 with complex limbal @entity12556 associated with @entity9720 ( @entity9720 ), a @entity395 including nevus sebaceous, @entity410 , and @entity1032 , and often accompanied by @entity735 . DESIGN: Small observational case series. METHODS: A retrospective review of the clinical and histopathologic records of four @entity1 . RESULTS: Each of four @entity1 had complex limbal @entity12556 in the setting of clinical and histopathologic @entity9720 . The limbal @entity12556 were multiple in three @entity1 and bilateral in two @entity1 . Most @entity12556 involved the superotemporal limbus (6 of 10), although nasal (3 of 10) and @entity5 also were present. Three @entity1 had significant corneal @entity940 or involvement of the central cornea requiring surgical removal of their @entity12556 , one accompanied by a lamellar keratoplasty and another accompanied by two consecutive penetrating keratoplasties. Each graft eventually vascularized, reducing vision. One @entity1 's vision was limited by amblyopia and another by occipital cortical @entity16490 with @entity227 . Histopathologic examination of the excised @entity12556 showed foci of lacrimal gland (3 of 4 @entity1 ), adipose tissue (3 of 4), neural tissue (1 of 4), cartilage (1 of 4), lymphoid follicles (1 of 4), skin adnexal tissue (1 of 4), and smooth muscle (1 of 4). Other associated ocular findings included an eyelid mass (1 of 4), @entity4643 of the eyelid (3 of 4), @entity4643 of the choroid and retina (2 of 4), nonparalytic strabismus (2 of 4), @entity5692 (1 of 4), partial @entity2895 with @entity1736 and anisocoria (1 of 4), @entity4353 (1 of 4), @entity5766 (1 of 4), and cortical @entity227 (1 of 4). CONCLUSIONS: Complex limbal @entity12556 , although rare, can occur in the setting of @entity9720 and can be associated with multiple ocular and @entity3002 . Visual prognosis appears poor in most cases despite aggressive management.

title: Complex limbal XXXX .

entities_list: @entity12556 :: ('MESH:D002828', 'Disease') :: ['choristomas']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizures']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['mental retardation']

entities_list: @entity940 :: ('MESH:D001251', 'Disease') :: ['astigmatism']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual impairment']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['inferior (1 of 10) limbal tumors']

entities_list: @entity4353 :: ('MESH:D008850', 'Disease') :: ['microphthalmia']

entities_list: @entity16490 :: ('MESH:D050033', 'Disease') :: ['dysgenesis']

entities_list: @entity3002 :: ('MESH:D009421', 'Disease') :: ['systemic abnormalities']

entities_list: @entity2895 :: ('MESH:D015840', 'Disease') :: ['oculomotor palsy']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['ocular anomalies']

entities_list: @entity9720 :: ('MESH:D054000', 'Disease') :: ['linear nevus sebaceous syndrome', 'LNSS']

entities_list: @entity4643 :: ('MESH:D003103', 'Disease') :: ['colobomas']

entities_list: @entity395 :: ('MESH:D035583', 'Disease') :: ['rare disorder']

entities_list: @entity5692 :: ('MESH:D015422', 'Disease') :: ['scleral ectasia']

entities_list: @entity5766 :: ('MESH:D006972', 'Disease') :: ['hypertelorism']

answer: @entity9720 :: (MESH:D054000,Disease) :: ['choristomas in linear nevus sebaceous syndrome']


abstract: Defence against invading DNA occurs in both mammals and bacteria. Recognition of stray DNA can initiate responses to infection, but may also protect against potentially mutagenic integration of transposons or retrotransposons into the genome. Double-stranded DNA detected in the cytosol of @entity1 macrophages can elicit inflammatory cytokines and cell death following assembly of the @entity3357 inflammasome. Amongst eukaryotes, responses to cytosolic DNA have so far only been detected in mammals, and @entity3357 is @entity1 restricted. In protecting genome integrity, we reasoned that pathways recognising invading DNA should be fundamental to cellular life, and that cell death would be an appropriate response to an overwhelming foreign DNA burden. We found that @entity238 S2 cells were killed by transfection of DNA from a range of natural sources. Unlike with @entity1 cells, responses were not prevented by DNA denaturation. There was an element of sequence specificity, as synthetic single-stranded homopolymers were not toxic, whilst mixed-base synthetic DNA caused significant cell death. @entity204 occurred with rapid loss of membrane integrity, and without the characteristic features of apoptosis. We have defined a novel defence against invading DNA in @entity238 . An active necrotic pathway has not previously been described in insects.    2014 S. Karger AG, Basel.

title: A Novel Pathway of Cell XXXX in Response to Cytosolic DNA in @entity238 Cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['mammalian']

entities_list: @entity238 :: ('7227', 'Species') :: ['Drosophila']

answer: @entity204 :: (MESH:D003643,Disease) :: ['Death']


abstract: PURPOSE: Nomograms are statistically based tools that provide the overall probability of a specific outcome. They have shown better individual discrimination than the current @entity2802 staging system in numerous @entity1 @entity5 models. The pancreatic nomogram combines individual clinicopathologic and operative data to predict disease-specific survival at 1, 2, and 3 years from initial resection. A single US institution database was used to test the validity of the @entity788 nomogram established at Memorial Sloan-Kettering Cancer Center. @entity1 AND METHODS: The nomogram was created from a prospective @entity788 database that included 555 consecutive @entity1 between October 1983 and April 2000. The nomogram was validated by an external @entity1 cohort from a retrospective @entity788 database at Massachusetts General Hospital that included 424 consecutive @entity1 between January 1985 and December 2003. RESULTS: Of the 424 @entity1 , 375 had all variables documented. At last follow-up, 99 @entity1 were alive, with a median follow-up time of 27 months (range, 2 to 151 months). The 1-, 2-, and 3-year disease-specific survival rates were 68% (95% CI, 63% to 72%), 39% (95% CI, 34% to 44%), and 27% (95% CI, 23% to 32%), respectively. The nomogram concordance index was 0.62 compared with 0.59 with the American Joint Committee on Cancer (AJCC) stage (P = .004). This suggests that the nomogram discriminates disease-specific survival better than the AJCC staging system. CONCLUSION: The @entity788 nomogram provides more accurate survival predictions than the AJCC staging system when applied to an external @entity1 cohort. The nomogram may aid in more accurately counseling @entity1 and in better stratifying @entity1 for clinical trials and molecular @entity5 analysis.

title: Validation of a postresection XXXX nomogram for disease-specific survival.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'pancreatic adenocarcinoma']

answer: @entity788 :: (MESH:D010190,Disease) :: ['pancreatic adenocarcinoma']


abstract: OBJECTIVE: To evaluate the correlation between @entity1714 and @entity6 . STUDY DESIGN: Cross-sectional study. PLACE AND DURATION OF STUDY: Eye Department of Postgraduate Medical Institute, Lahore General Hospital, from August 2012 to February 2013. METHODOLOGY: A total of 258 @entity1 suffering from type-2 @entity6 were included. Axial length was measured by two optometrists using contact type ultrasound biometer. Colored retinal photographs, red free retinal photographs and Fundus Fluorescein Angiography (FFA) were performed on all @entity1 using standard fundus camera. All fundus photographs and angiograms were independently reviewed and graded by two qualified vitreoretinal fellows. RESULTS: Out of 258 @entity1 , 163 were males (63.2%) and 95 (36.8%) were females. Average age of @entity1 was 56.30    7.57 years. Average axial length of right and left eyes were 23.16 mm and 23.15 mm respectively. There was statistically significant negative correlation between axial length and severity of @entity6 in the right eye, (Spearman correlation = -0.511, p = 0.0001) as well as the left eye (Spearman correlation = -0.522, p = 0.0001). CONCLUSION: There is a protective influence of longer axial length of globe on the stage and severity of @entity6 . This study may help in modifying the screening protocol for @entity6 amongst @entity1 of differing axial lengths.

title: XXXX and its influence on @entity6 .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity1714 :: ('MESH:D009216', 'Disease') :: ['axial myopia']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic retinopathy']

answer: @entity1714 :: (MESH:D009216,Disease) :: ['Axial myopia']


abstract: BACKGROUND: The purpose of this study was to assess the effectiveness of free tissue transfer for treatment of @entity1442 ( @entity7190 ) in @entity135 @entity1 . METHODS: We reviewed 29 @entity1 who were treated for advanced mandibular @entity7190 by radical resection and reconstruction with free flaps at our institution. All @entity1 had either failed to respond to conservative treatment, including hyperbaric @entity26 therapy and debridement or had @entity174 due to @entity7190 . RESULTS: Twenty-four vascularized bone (17 fibula, five iliac, and two scapula), four rectus abdominis myocutaneous, and one radial forearm fasciocutaneous free flaps were used. The complications occurred in 6 of 29 @entity1 (21%). A total of four flaps (14%) were lost. The mean follow-up was 2 years 9 months. All @entity1 had complete resolution of @entity7190 symptoms. No evidence of @entity7190 recurrence was observed in any @entity1 . CONCLUSION: For advanced @entity7190 of the mandible, radical resection followed by reconstruction using free flap provides a reliable means of obtaining good wound healing with acceptable aesthetic and functional results.

title: Management of XXXX with free flap reconstruction.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity135 :: ('MESH:D006258', 'Disease') :: ['head and neck cancer']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['pathological fracture']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity7190 :: ('MESH:D010025', 'Disease') :: ['ORN', 'osteoradionecrosis']

entities_list: @entity1442 :: ('MESH:D020178', 'Disease') :: ['advanced mandibular osteoradionecrosis']

answer: @entity1442 :: (MESH:D020178,Disease) :: ['advanced mandibular osteoradionecrosis']


abstract: BACKGROUND: Addition of high-dose @entity2592 (HDCA) to the conventional @entity786 /total-body irradiation (CY/ @entity131 ) regimen significantly improved prognosis after cord blood transplantation (CBT) for adult @entity3052 ( @entity3052 ) and @entity2590 ( @entity2590 ). The efficacy of HDCA in bone marrow or peripheral blood stem cell transplantation (BMT/PBSCT), however, has not yet been elucidated. FINDINGS: We conducted a cohort study to compare the prognosis of HDCA/CY/ @entity131 (N   =   435) and CY/ @entity131 (N   =   1667) in BMT/PBSCT for @entity3052 / @entity2590 using a Japanese transplant registry database. The median age was 38  years, and 86.0  % of the @entity1 had @entity3052 . Unrelated donors comprised 54.6  %, and 63.9  % of donors were human leukocyte antigen (HLA)-matched. Overall survival (OS) was not improved in the HDCA/CY/ @entity131 group (adjusted hazard ratio (HR), 1.14; p   =   0.13). Neutrophil engraftment was inferior (HR, 0.80; p   <   0.01), and the incidence of @entity2335 and @entity9818 increased in HDCA/CY/ @entity131 (HR, 1.47 and 1.60; p   =   0.06 and 0.04, respectively), leading to significantly higher non-relapse mortality (NRM; HR, 1.48; p   <   0.01). Post-transplant relapse and @entity5 -related mortality were not suppressed by the addition of HDCA. CONCLUSIONS: This study indicated the inefficacy of HDCA/CY/ @entity131 in BMT/PBSCT for @entity3052 / @entity2590 . Our results should be validated in large-scale prospective studies.

title: Clinical significance of high-dose @entity2592 added to XXXX /total-body irradiation in bone marrow or peripheral blood stem cell transplantation for @entity5 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity9818 :: ('MESH:D057049', 'Disease') :: ['thrombotic microangiopathy']

entities_list: @entity2590 :: ('MESH:D009190', 'Disease') :: ['myelodysplastic syndrome', 'MDS']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myelogenous leukemia', 'AML']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine']

entities_list: @entity2335 :: ('MESH:D003556', 'Disease') :: ['hemorrhagic cystitis']

answer: @entity786 :: (MESH:D003520,Chemical) :: ['cyclophosphamide']


abstract: UNASSIGNED: Benefits of n-3 @entity1474 ( @entity5204 ) against @entity65 have been reported. Vascular tone regulation is largely mediated by endothelial factors whose release is modulated by sex hormones. Since the incidence of @entity65 has been correlated with decreased levels of sex hormones, the aim of this study was to analyze whether a diet supplemented with the specific @entity5204 @entity4600 ( @entity4601 ) could prevent vascular changes induced by an @entity73 . For this purpose, control and orchidectomized @entity35 were fed with a standard diet supplemented with 5% (w/w) sunflower oil or with 3% (w/w) sunflower oil plus 2% (w/w) @entity4601 . The lipid profile, the blood pressure, the production of @entity2918 and @entity842 (NO), and the redox status of biological samples from control and orchidectomized @entity35 , fed control or @entity4601 -supplemented diet, were analyzed. The vasodilator response and the contribution of NO, @entity2918 and hyperpolarizing mechanisms were also studied. The results showed that orchidectomy negatively affected the lipid profile, increased the production of @entity2918 and reactive @entity26 species (ROS), and decreased NO production and the antioxidant capacity, as well as the participation of hyperpolarizing mechanisms in the vasodilator responses. The @entity4601 -supplemented diet of the orchidectomized @entity35 decreased the release of @entity2918 and ROS, while increasing NO production and the antioxidant capacity, and it also improved the lipid profile. Additionally, it restored the participation of hyperpolarizing mechanisms by activating @entity972 . Since the modifications induced by the @entity4601 -supplemented diet were observed in the orchidectomized, but not in the healthy group, @entity4601 seems to exert cardioprotective effects in physiopathological situations in which @entity455 exists.

title: Effect of Dietary XXXX Supplementation on the Participation of Vasodilator Factors in Aorta from Orchidectomized @entity35 .

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular dysfunction']

entities_list: @entity4600 :: ('CHEBI:28125', 'Chemical') :: ['docosahexaenoic acid']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired gonadal function']

entities_list: @entity2918 :: ('MESH:D011453', 'Chemical') :: ['prostanoids']

entities_list: @entity1474 :: ('MESH:D005231', 'Chemical') :: ['polyunsaturated fatty acids']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular pathologies', 'cardiovascular diseases']

answer: @entity4600 :: (CHEBI:28125,Chemical) :: ['Docosahexaenoic Acid']


abstract: OBJECTIVES: To review outcomes after curative treatment for @entity418 in the Vancouver Island Cancer Centre from 1993 to 1998. Curative treatments included esophagectomy alone, and chemoradiotherapy with "selective surgery" for @entity1 with post-treatment-positive endoscopic biopsy or less than 75% regression on computed axial tomography scan, or with resectable local recurrence. METHODS: @entity1 undergoing esophagectomy alone, or primary chemoradiotherapy and "selective surgery" were reviewed. This was a retrospective, nonrandomized, institutional experience. @entity532 , relief of @entity1282 , disease-specific survival rates and prognostic factors were analyzed. RESULTS: Nineteen @entity1 underwent esophagectomy alone. A total of 56 @entity1 underwent primary chemoradiotherapy, of whom 16 had "selective surgery". Relief of @entity1282 was similar in both groups of esophagectomy @entity1 . Exploration for "selective surgery" was performed in 12 @entity1 after their first postchemo-radiotherapy endoscopy (two @entity1 had unresectable disease), and in seven for relapse, one of whom died intraoperatively. Overall, the mortality rate due to surgery was 3%. Chemoradiotherapy was not associated with more frequent serious surgical complications. For @entity1 who underwent esophagectomy alone and those who underwent chemoradiotherapy plus selective surgery, the median survival times were 12.9 and 16.4 months, respectively, and the three-year survival rates were 21% and 37%, respectively. Seventeen of 25 @entity1 who underwent chemoradiotherapy and who survived more than two years have not required selective surgery. For the two groups of @entity1 combined, no single prognostic factor for survival was significant in multivariate analysis, but for @entity1 who underwent chemoradiotherapy plus selective surgery, negative endoscopic biopsy was highly significant. CONCLUSIONS: @entity532 and disease-specific survival rates after primary chemoradiotherapy with selective surgery compare favourably with esophagectomy alone in the curative treatment of @entity418 . A prospective, randomized trial is necessary for the definitive evaluation of the strategy of chemoradiotherapy and selective surgery.

title: Curative treatment for XXXX : Vancouver Island Cancer Centre experience from 1993 to 1998.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['Surgical complication']

entities_list: @entity418 :: ('MESH:D004938', 'Disease') :: ['esophageal cancer']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

answer: @entity418 :: (MESH:D004938,Disease) :: ['esophageal cancer']


abstract: The term " @entity2783 " encompasses the heterogeneous group of diseases caused by the extracellular deposition of autologous fibrillar proteins. The global incidence of @entity2783 is estimated at five to nine cases per million @entity1 -years. While @entity3917 ( @entity3917 ) @entity2783 is more frequent in developed countries, @entity1129 ( @entity1129 ) @entity2783 is more common in some European regions and in developing countries. The spectrum of @entity2783 has changed in recent decades owing to: an increase in the median age at diagnosis; a percent increase in the frequency of primary @entity2783 with respect to the @entity1129 type; and a substantial change in the epidemiology of the underlying diseases. Diagnosis of @entity2783 is based on clinical organ involvement and histological evidence of @entity527 . Among the many tinctorial characteristics of @entity527 , avidity for Congo red and metachromatic birefringence under unidirectional polarized light remain the gold standard. Once the initial diagnosis has been made, the amyloid subtype must be identified and systemic organ involvement evaluated. In this sense, the (123)I-labeled serum amyloid P component scintigraphy is a safe and noninvasive technique that has revolutionized the diagnosis and monitoring of treatment in @entity1582 . It can successfully identify anatomical patterns of @entity527 throughout the body and enables not only an initial estimation of prognosis, but also the monitoring of the course of the disease and the response to treatment. Given the etiologic diversity of @entity2783 , common therapeutic strategies are scarce. All treatment options should be based upon a greater control of the underlying disease, adequate organ support, and treatment of symptoms. Nevertheless, novel therapeutic strategies targeting the formation of amyloid fibrils and @entity527 may generate new expectations for @entity1 with @entity2783 .

title: XXXX : epidemiology, diagnosis, and management.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity527 :: ('MESH:D058225', 'Disease') :: ['amyloid deposits', 'amyloid deposition']

entities_list: @entity2783 :: ('MESH:D000686', 'Disease') :: ['AA amyloidosis', 'amyloidosis', 'AL amyloidosis']

entities_list: @entity1582 :: ('MESH:D009101', 'Disease') :: ['systemic amyloidosis']

entities_list: @entity3917 :: ('MESH:D020795', 'Disease') :: ['amyloid light-chain', 'AL']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['Systemic AA amyloidosis']


abstract: BACKGROUND: Circulating @entity5 cells (CTCs) are associated with prognosis in a variety of @entity1 @entity5 and have been proposed as a liquid biopsy for follow-up examinations. We show that @entity5 suppressor and @entity3 suppressor genes are epigenetically silenced in CTCs isolated from peripheral blood of @entity0 @entity1 . METHODS: We obtained peripheral blood from 56 @entity1 with operable @entity0 , 27 @entity1 with verified @entity3 , and 23 healthy individuals. We tested DNA extracted from the EpCAM-positive immunomagnetically selected CTC fraction for the presence of methylated and unmethylated @entity57911 , @entity13311 , and @entity13050 promoter sequences by methylation-specific PCR (MSP). All samples were checked for @entity4166 ( @entity4166 , formerly @entity4166 ) expression by reverse-transcription quantitative PCR. RESULTS: In CTCs of @entity1 with operable @entity0 , promoter methylation of @entity57911 was observed in 17.9%, @entity13311 in 32.1%, and @entity13050 in 53.6% of @entity1 . In CTCs of @entity1 with verified @entity3 , promoter methylation of @entity57911 was observed in 37.0%, @entity13311 in 44.4%, and @entity13050 in 74.1%. In healthy individuals, promoter methylation of @entity57911 was observed in 4.3%, @entity13311 in 8.7%, and @entity13050 in 4.3%. DNA methylation of these genes for both operable and metastatic @entity0 was significantly different from that of the control population. CONCLUSIONS: DNA methylation of @entity5 suppressor and @entity3 suppressor genes is a hallmark of CTCs and confirms their heterogeneity. Our findings add a new dimension to the molecular characterization of CTCs and may underlie the acquisition of malignant properties, including their stem-like phenotype.

title: DNA methylation of XXXX suppressor and @entity3 suppressor genes in circulating @entity5 cells.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity5 :: (MESH:D009369,Disease) :: ['tumor']