abstract: UNASSIGNED: 9722 Background: The serum troponin-T ( @entity10020 ) level increases with @entity296 . We sought to assess whether @entity10020 level could be a useful marker for the early detection of @entity5948 @entity1370 . METHODS: 41 @entity1 who had been planned to receive @entity5948 containing combination chemotherapy were included into the study. Serum @entity10020 levels were measured before (baseline) and after first cycle of chemotherapy, and repeated after the last cycle of chemotherapy. In all @entity1 , the left ventricular ejection fraction (LVEF), fractional shortening (FS), early peak flow/atrial flow (E/A) velocity ratio, and the isovolemic relaxation time (IRT) were measured echocardiographically, both before and after the study. RESULTS: LVEF and FS did not change in any @entity1 . In 21 @entity1 (49%), the E/A ratio decreased after therapy. The decrease in E/A ratio was more prominent in @entity1 who were older than mean age of our study group which was 44 years (p<0.05). The post-therapy IRT was prolonged (94.0  2.0 vs 85.6  10.5 msec). @entity10020 levels after completion of therapy were elevated in 14 (34%) @entity1 , but it exceeded the upper limit of normal range (>0.01 ng/mL) only in a single case. @entity10020 levels after completion of therapy were significantly higher, compared to those baseline and after the first cycles of therapy (p<0.05). In the younger age group (<= 44 years), there was a 2-fold decrease in the E/A ratio in @entity1 whose @entity10020 levels increased during the therapy, compared to those whose @entity10020 levels did not change (21% vs 43%, p<0.05) (Table 1). CONCLUSIONS: Increased serum @entity10020 levels can be detected in the early stages of @entity5948 therapy and it is associated with @entity67 of the left ventricle. Therefore, serum @entity10020 level could be a useful marker for the early detection of @entity5948 -induced @entity296 . [Figure: see text] No significant financial relationships to disclose.

title: Increased Troponin-T level is associated with @entity5948 -induced XXXX of the left ventricle.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy', 'myocardial damage']

entities_list: @entity5948 :: ('D018943', 'Chemical') :: ['anthracycline']

entities_list: @entity67 :: ('MESH:D018754', 'Disease') :: ['diastolic dysfunction']

entities_list: @entity1370 :: ('MESH:D066126', 'Disease') :: ['cardiotoxicity']

answer: @entity67 :: (MESH:D018754,Disease) :: ['diastolic dysfunction']


abstract: BACKGROUND: Simple neurectomy is a standard treatment of @entity2950 after failure of conservative treatment. Recently, neurectomy with intramuscular implantation of the proximal nerve stump has been proposed as a safe and effective alternative method providing significant @entity158 improvement. However, there remains little evidence supporting one technique over the other. The purpose of this study was to compare functional outcomes and complications of simple neurectomy versus neurectomy with intramuscular implantation. METHODS: Retrospective chart review along with prospectively collected data of 99 consecutive @entity1 (105 feet with 118 @entity2950 ) who were diagnosed with @entity2950 of the foot and underwent simple neurectomy (66 @entity1 / 72 feet / 78 @entity2950 ) and neurectomy with intramuscular implantation of proximal nerve stump into intrinsic muscle of foot (33 @entity1 / 33 feet / 40 @entity2950 ) between 2000 and 2013. The minimum follow-up to be included in the study was 6 months for both techniques (mean = 44.6 months, range = 6 to 150 months for simple neurectomy; and mean = 19.3 months, range = 6 to 66 months for neurectomy with intramuscular implantation of proximal nerve stump into the intrinsic muscle). The primary outcomes were @entity10395 ( @entity10395 ); @entity158 , disability, activity limitation, and total score, Short Form-36 (SF-36: physical and mental component scores); and visual analog scale (VAS). Secondary outcomes included operative time and complications. Pre- and postoperative SF-36, and @entity10395 , and @entity158 (VAS) scores were obtained and compared using a paired t test. An independent t test was used to assess the functional outcomes and operative time between the 2 groups, and a chi-square test was used to compare the complications between the 2 techniques. RESULTS: Both groups demonstrated signi   cant improvement of postoperative functional outcomes ( @entity10395 , SF-36, and VAS; P < .001, all) compared to the preoperative period. Neurectomy with intramuscular implantation demonstrated significant improvement of @entity158 compared to simple neurectomy as measured with VAS (P = .002); however, the operative time was significantly longer than the simple neurectomy technique (P = .001). The rest of the functional outcomes measured were comparable between the 2 techniques. Complications in both simple neurectomy and implantation techniques were persistent @entity158 (11.5% vs 2.5%, P = .07), revision rate (5.1% vs 0.0%, P = .08), and @entity158 (5.1% vs 5.0%, P = .83), respectively, but it did not reach statistical significance (P > .05, all). CONCLUSION: Both simple neurectomy and neurectomy with intramuscular implantation demonstrated significant improvement in terms of functional outcomes as measured with the @entity10395 , SF-36, and VAS in @entity1 with @entity2950 . Although requiring a longer operative time, neurectomy with intramuscular implantation technique might offer superior @entity158 relief with comparable complications to the simple neurectomy technique. LEVEL OF EVIDENCE: Level III, retrospective comparative study.

title: Simple Neurectomy Versus Neurectomy With Intramuscular Implantation for XXXX : A Comparative Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2950 :: ('MESH:D009463', 'Disease') :: ['interdigital neuroma', 'interdigital nerve neuroma', 'neuromas']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['painful scar', 'pain']

entities_list: @entity10395 :: ('MESH:D005534', 'Disease') :: ['FFI', 'Foot Function Index']

answer: @entity2950 :: (MESH:D009463,Disease) :: ['Interdigital Neuroma']


abstract: OBJECTIVE: Many @entity1 with @entity449 ( @entity2334 ). Because open repair is associated with a high morbidity and mortality, hybrid approaches to @entity2334 repair are emerging. In this study, we evaluated the midterm outcomes and aortic remodeling of a hybrid technique that combines proximal @entity439 repair (TEVAR), followed by staged distal open thoracoabdominal repair for @entity1 with Crawford extent I or II TAAAs secondary to chronic @entity1580 . METHODS: We identified 19 @entity1 with Crawford extent I (n  = 1) or extent II (n  = 18) TAAAs secondary to chronic @entity1580 who underwent a staged hybrid repair from 2007 to 2014 at our institution. Nine @entity1 had previous open ascending aortic surgery for type I @entity1580 . Stage 1 TEVAR was performed via percutaneous (n  = 8), femoral cutdown (n  = 8), or iliac exposure (n  = 3). The left subclavian artery was covered in nine @entity1 and revascularized in eight @entity1 using carotid-subclavian bypass (n  = 7) or laser fenestration (n  = 1). Stage 2 open repair was performed a median of 18  weeks later with partial cardiopulmonary bypass via left femoral arterial and venous cannulation for visceral and lower body perfusion. The open thoracoabdominal graft was anastomosed proximally in an end to end fashion with the endograft. We then assessed surgical morbidity and mortality, midterm survival, and freedom from reintervention. Aortic remodeling was measured and change in maximum aortic and false lumen diameter at last follow-up (median, 3  years) from baseline was assessed. RESULTS: There were no deaths, @entity64 , or @entity177 in this cohort. After stage 1 TEVAR, three @entity1 required repeat intervention for endoleak (type IA, n  = 1; type IB, n  = 1; type II, n  = 1) before open repair. After stage 2 open repair, there was a single delayed permanent @entity912 2  weeks after discharge. At a median 3-year follow-up (range, 6 months-6.2  years), there were no deaths, neurologic events, @entity1070 , or @entity2334 reinterventions. Complete false lumen @entity715 occurred in 100% of the @entity1 , with maximum false lumen diameter decreasing from 34.3     15.3  mm to 13.2     12.0  mm  (P  < .01) and total aortic diameter decreasing from 60.2     9.0  mm to 49.4     9.6  mm  (P  <  .01). CONCLUSIONS: Staged hybrid @entity2334 repair, using a combination of proximal TEVAR with open distal repair, can be performed using established endovascular skills and technology coupled with traditional open aortic surgical techniques, with low surgical morbidity and mortality. In the midterm, staged hybrid @entity2334 repair was associated favorable survival, aortic remodeling, and freedom from reintervention.

title: Staged hybrid repair of extensive @entity2334 secondary to chronic XXXX .

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes']

entities_list: @entity449 :: ('MESH:D001014', 'Disease') :: ['aortic dissection develop Crawford extent I or II thoracoabdominal aortic aneurysms']

entities_list: @entity912 :: ('MESH:D010243', 'Disease') :: ['paralysis']

entities_list: @entity1070 :: ('MESH:D057867', 'Disease') :: ['endoleaks']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['thoracic endovascular aneurysm']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1580 :: ('MESH:C562834', 'Disease') :: ['aortic dissection']

answer: @entity1580 :: (MESH:C562834,Disease) :: ['aortic dissection']


abstract: OBJECTIVES: In @entity309 ( @entity309 ) and @entity571 ( @entity571 ) forefoot involvement causes disability and @entity7529 . Our objective was to evaluate, in @entity309 and @entity571 @entity1 , the efficacy of two protocols combining insoles in polypropylene terephtalate ( @entity3445 ) and custom @entity1346 orthoses for toes on disability and @entity7529 . METHODS: Twenty-four @entity1 (13 with @entity571 , 11 with @entity309 ) with @entity7529 were treated with two protocols: group A (protocol A) wore @entity3445 insoles (T1) for 30 days and for another 30 days @entity1346 orthosis for toes were added (T2). Group B (protocol B) wore @entity3445 insoles and @entity1346 orthosis (T1) for 30 days and in the following 30 days only insoles (T2). At T0, T1 and T2, @entity158 , disability and function (Foot Function Index - FFI), pressure (KPA) and plantar contact areas (cm2) (baropodometer), and gait spatial-temporal parameters (GAITRite  ) were assessed. RESULTS: At T0 versus T2, both protocols reduced @entity158 , -disability and -functional limitation (p<0.05), with better results of protocol A than protocol B (p<0.05) for @entity158 and -disability. Both protocols reduced baropodometer foot plantar pressures (p<0.001), with better results for protocol A for right foot pressures (p<0.05) and increased foot contact areas (p<0.05), with no difference between them (p=NS). Gait parameters were not significantly changed by both protocols (p=NS). CONCLUSIONS: In @entity1 with @entity309 and @entity571 with @entity7529 , the synergic action of @entity1346 toe orthosis and @entity3445 insoles improves FFI, @entity551 and increases foot plantar contact areas. Protocol A, using firstly insoles and then adding @entity1346 toe orthoses, is the more efficacious.

title: A comparison of two podiatric protocols for @entity7529 in @entity1 with XXXX and @entity571 .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA']

entities_list: @entity7529 :: ('MESH:D037061', 'Disease') :: ['metatarsalgia']

entities_list: @entity1346 :: ('MESH:D012828', 'Chemical') :: ['silicone']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['reduces foot plantar pressures']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: OBJECTIVE AND IMPORTANCE: A disadvantage of transarticular and C2 pedicle screws is vertebral artery (VA) injury as a result of screw misplacement. If unilateral occlusion of the VA is present, @entity1317 of the dominant side will cause fatal complications as a result of @entity1887 . Several authors have recently reported the usefulness of C2 laminar screws because of their safety on @entity1317 . We used transarticular and C2 laminar screws combined with the atlas hook in a @entity1 with C1-2 instability and unilateral VA occlusion, in order to reduce the risk of further @entity1317 . CLINICAL PRESENTATION: A 64-year-old @entity1 with @entity309 and @entity4048 . Preoperative MR angiography showed a left side VA occlusion. TECHNIQUE: The @entity1 underwent atlantoaxial, posterior fusion using a transarticular screw on the side of the occlusion and a C2 laminar screw on the dominant side combined with a bilateral atlas hook. The transarticular screw was inserted using a navigation system and image intensifier, and the laminar screw was inserted free hand. Bone grafting from the iliac crest was performed. CONCLUSION: Transarticular and C2 laminar screws fixation combined with the atlas hook in a @entity1 with unilateral VA occlusion is a useful technique, in order to reduce the risk of further @entity1317 .

title: Safety of atlantoaxial fusion using laminar and transarticular screws combined with an atlas hook in a XXXX with unilateral vertebral artery occlusion (case report).

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity1887 :: ('MESH:D000309', 'Disease') :: ['collateral flow insufficiency']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid atlantoaxial subluxation complained of cervical myelopathy']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: In pancreatic islet transplantation, revascularization is crucial for the graft's survival and function. In this study, the endothelium of isolated islets and revascularization and function of islet isografts in @entity6 @entity35 were investigated. Islets were isolated from Lewis @entity35 by collagenase digestion method and were examined using immunohistochemistry ( @entity18518 stain) on days 0, 1, 3, and 7 after isolation. The number of @entity18518 -positive cells in these isolated islets was counted (mean +/- SD %). Isografts (freshly isolated islets: group A, and islets cultured for 7 days: group B) transplanted in the renal subcapsule of @entity3839 -induced @entity6 Lewis @entity35 were examined using immunohistochemistry ( @entity18518 stain) on days 3, 5, and 7 after transplantation. Intravenous @entity413 tolerance tests (IVGTT) were performed on days 3 and 7 after transplantation. The number of @entity18518 -positive cells in the isolated islets on days 0, 1, 3, and 7 after isolation were: 17.3 +/- 4.1%, 8.2 +/- 0.7%, 2.1 +/- 0.8%, and 0.8 +/- 0.5%, respectively (p < 0.05). On day 5 after transplantation, @entity18518 -positive cells were not detected in group A and B grafts, but were detected in both groups in periphery of the islets. On day 7, @entity18518 -positive microvessels were present throughout the entire graft. IVGTT values in groups A and B on days 3 and 7 after transplantation did not show significant differences. In renal subcapsular isografts in @entity6 @entity35 , revascularization into islet grafts occurs from the surrounding host tissue 5 days after transplantation, but has no influence on the response to @entity413 during this period.

title: Revascularization and function of pancreatic islet isografts in XXXX @entity35 following transplantation.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetic']

entities_list: @entity3839 :: ('MESH:D013311', 'Chemical') :: ['streptozotocin']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetic']


abstract: UNASSIGNED: Chromosome rearrangement is clinically and physiologically important because it can produce oncogenic fusion genes. Chromosome rearrangement requires DNA double-strand breaks (DSBs) at two genomic locations and misrejoining between the DSBs. Before DSB misrejoining, two DSB-containing chromatin regions move and pair with each other; however, the molecular mechanism underlying this process is largely unknown. We performed a spatiotemporal analysis of ionizing radiation-induced foci of @entity15664 ( @entity15664 ), a marker for DSB-containing chromatin. We found that some @entity15664 foci were paired, indicating that the two damaged chromatin regions neighboured one another. We searched for factors regulating the foci pairing and found that the number of paired foci increased when @entity10321 , @entity10322 , or ATM was absent. In contrast, @entity15664 depletion reduced the number of paired foci and dicentric chromosomes-an interchromosomal rearrangement. Foci were paired more frequently in heterochromatin than in euchromatin in control cells. Additionally, the reduced foci pairing in @entity15664 -depleted cells was rescued by concomitant depletion of a heterochromatin building factor such as Kr  ppel-associated box-associated protein 1 or @entity34255 . These findings indicate that pairing between DSB-containing chromatin regions was suppressed by @entity10321 , @entity10322 , and ATM, and this pairing was promoted by @entity15664 through chromatin relaxation.

title: Regulation of pairing between broken DNA-containing chromatin regions by XXXX , @entity10322 , ATM, and 53BP1.

entities_list: @entity34255 :: ('1107', 'Gene') :: ['chromodomain helicase DNA-binding protein 3']

answer: @entity10321 :: (7520,Gene) :: ['Ku80']


abstract: The localization of the S-antigen was studied by electron microscopy in the @entity95 eye, under three conditions of adaptation: A) 24-hour dark adaptation, B) 24-hour dark adaptation and 1.5-hour light adaptation and C) light adaptation for 30 hours. The Fab' fraction of the IgG of @entity95 against the swine S-antigen was labeled with horseradish peroxidase (HRP) and was used as the marking antibody. In Group A, the HRP reaction products indicating the S-antigen were found mainly in the disk and plasma membranes of the outer segments of the photoreceptor cells. The reaction products were also found diffusely in the cytoplasm of the inner segment with the exception of the mitochondria and nucleus. In Group B, the phagosomes were found surrounded by the multilayered microvilli of the @entity989 ( @entity989 ) cells; the reaction products were scarcely found in the phagosomes but were seen in the microvilli. Some weak reaction products were also encountered in the cytoplasm of the @entity989 cells. In Group C, after 30-hour light adaptation, many phagosomes were found but they contained almost no reaction products. However, the microvilli of the @entity989 cells surrounding the phagosomes showed a fair amount of the reaction products. The cytoplasm of the @entity989 cells contained abundant reaction products, particularly in the area of the basal infoldings. The reaction products were also seen in the Bruch's membrane and the endothelial cells of the choriocapillaris. It was thought that the S-antigen is taken up by the @entity989 during phagocytosis of the shed outer segments and is transported to the choriocapillaris.

title: Localization of S-antigen under various conditions of light or dark adaptation in the XXXX .

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelial', 'RPE']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: The induction of targeted drugs for the treatment of @entity1358 has changed the treatment strategy for systemic therapy. Surgical treatment for @entity1358 should also be reconsidered in the light of the effect of targeted drugs. The clinical benefit of cytoreductive nephrectomy for cases of @entity1358 was proved in randomized trials in the cytokine era. However, at present, there has not been level 1 evidence for this in the targeted therapy era. @entity1 with better performance status and without poor risk factors tend to benefit from cytoreductive nephrectomy. Two ongoing large-scale randomized studies might shed light on this issue. One of the remarkable differences in the efficacy between cytokines and targeted drugs, particularly @entity4149 kinase inhibitors, is the reduction in the size of the @entity5 by @entity4149 kinase inhibitors, including @entity2240 and @entity16231 . Initial experiences with targeted therapy suggest that the neoadjuvant setting of @entity4149 kinase inhibitors could be a viable option when the @entity5 shows local invasion and/or is unresectable. The present study does not support the routine neoadjuvant use of @entity2240 because of the possibility of disease progression during the neoadjuvant therapy, and modest response and benefit. @entity16231 , in contrast, shows larger reduction in the size of the @entity5 and might be used in the near future. Another issue is the combination of targeted therapy with metastasectomy. There is a lack of evidence for improved prognosis resulting from the neoadjuvant setting of @entity4149 kinase inhibitors followed by metastasectomy. Further studies are warranted to investigate this.

title: Treatment strategies for advanced XXXX : A new paradigm for surgical treatment.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib']

entities_list: @entity16231 :: ('MESH:C503983', 'Chemical') :: ['Axitinib', 'axitinib']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['primary tumors', 'primary tumor']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['metastatic renal cell carcinoma']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['renal cell carcinoma']


abstract: BACKGROUND AND AIMS: We published that threatening life experiences and adverse family relations impact @entity30 ( @entity30 ) adversely. In this study, we examine the influence of these stressors in @entity31 ( @entity31 ). PATIENTS AND METHODS: Patients completed demography, @entity159 ( @entity159 ), the Patient-Simple Clinical @entity1960 Activity Index (P-SCCAI), the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), the Short-Form Health Survey (SF-36), the Brief Symptom Inventory (BSI), the Family Assessment Device (FAD), and the List of Threatening Life Experiences (LTE). Analysis included multiple linear and quantile regressions and structural equation modeling, comparing @entity30 . RESULTS: @entity31 patients (N=148, age 47.55  16.04 years, 50.6% women) had scores [median (interquartile range)] as follows: SCAAI, 2 (0.3-4.8); FAD, 1.8 (1.3-2.2); LTE, 1.0 (0-2.0); SF-36 Physical Health, 49.4 (36.8-55.1); SF-36 Mental Health, 45 (33.6-54.5); Brief Symptom Inventory-Global Severity Index (GSI), 0.5 (0.2-1.0). SIBDQ was 49.76  14.91. There were significant positive associations for LTE and SCAAI (25, 50, 75% quantiles), FAD and SF-36 Mental Health, FAD and LTE with GSI (50, 75, 90% quantiles), and @entity159 with SF-36 and SIBDQ. The negative associations were as follows: LTE with SF-36 Physical/Mental Health, SIBDQ with FAD and LTE, @entity159 with GSI (all quantiles), and P-SCCAI (75, 90% quantiles). In structural equation modeling analysis, LTE impacted @entity159 negatively and @entity159 impacted GSI negatively; LTE impacted GSI positively and GSI impacted P-SCCAI positively. In a split model, @entity159 had a greater effect on GSI in @entity31 than @entity30 , whereas other path magnitudes were similar. CONCLUSION: Threatening life experiences, adverse family relations, and poor @entity159 make @entity31 patients less healthy both physically and mentally. The impact of @entity159 is worse in @entity31 than @entity30 .

title: Effect of threatening life experiences and adverse family relations in XXXX : analysis using structural equation modeling and comparison with @entity30 .

entities_list: @entity31 :: ('MESH:D003093', 'Disease') :: ['ulcerative colitis', 'UC']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ['CD', "Crohn's disease"]

entities_list: @entity159 :: ('MESH:D013226', 'Disease') :: ['economic status', 'ES']

answer: @entity31 :: (MESH:D003093,Disease) :: ['ulcerative colitis']


abstract: Studying saccades can illuminate the more complex decision-making processes required for everyday movements. The double-step task, in which a target jumps to two successive locations before the subject has time to react, has proven a powerful research tool to investigate the brain's ability to program sequential responses. We asked how @entity1 with a range of @entity76 responded to the double-step task, specifically, whether the initial saccadic response made to a target is affected by the appearance of a second target jump. We also sought to determine whether cerebellar @entity1 were able to make corrective saccades towards the remembered second target location if it were turned off soon after presentation. We tested saccades to randomly interleaved single- and double-step target jumps to eight locations on a circle. @entity1 's initial responses to double-step stimuli showed 50% more error than saccades to single target jumps, and often, they failed to make a saccade to the first target jump. The presence of a second target jump had similar, but smaller effects in control subjects (error increased by 18%). During memory-guided double-step trials, both @entity1 and controls made corrective saccades in darkness to the remembered location of the second jump. We conclude that in cerebellar @entity1 , the second target jump interferes with programming of the saccade to the first target jump of a double-step stimulus; this defect highlights @entity1 ' impaired ability to respond appropriately to sudden, conflicting changes in their environment. Conversely, since cerebellar @entity1 can make corrective memory-guided saccades in darkness, they retain the ability to remember spatial locations, possibly due to non-retinal neural signals (corollary discharge) from cerebral hemispheric areas concerned with spatial localization.

title: Effects of XXXX on sequences of rapid eye movements.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity76 :: ('MESH:D002526', 'Disease') :: ['cerebellar disorders']

answer: @entity76 :: (MESH:D002526,Disease) :: ['cerebellar disease']


abstract: OBJECTIVE: To characterize @entity1 with @entity410 that only occur without their @entity3596 (SWA). METHODS: Twenty-four @entity1 with SWA were retrospectively identified by chart review and subsequently underwent video-EEG monitoring (VEM). Eleven @entity1 met selection criteria for SWA and were never aware of any @entity410 . A case-matched control group of @entity1 who were always aware (SA) was used for comparison. Statistical analysis included Pearson's Chi-square, Fisher's Exact, and Mann-Whitney. RESULTS: @entity1 with SWA were older at @entity410 diagnosis than those with SA (p=0.04), were less often referred for evaluation of @entity410 or @entity302 (p=0.04), and were referred faster for VEM, despite SWA were significantly less likely to include motor manifestations (p=0.0004). SWA more often had temporal lobe onsets (p<0.0001) with left lateralization on ictal EEG (p<0.0001). At final follow up, @entity1 with SWA had tried fewer antiseizure drugs (p=0.03), but reported @entity410 freedom as often as @entity1 with SA (p=0.4). SIGNIFICANCE: We suggest that @entity1 with SWA have a @entity302 . @entity1 with absent recall were older, referred later, had fewer motor signs, and dominant hemisphere limbic localization than @entity1 with SA, but fewer antiseizure drugs are used in treatment. @entity1 with SWA can be detected from the clinical history, though serial VEM is needed to validate effective management.

title: Focal @entity410 without XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['unique epilepsy syndrome', 'epilepsy']

entities_list: @entity3596 :: ('MESH:D058926', 'Disease') :: ['awareness']

answer: @entity3596 :: (MESH:D058926,Disease) :: ['awareness']


abstract: OBJECTIVE: The Zenith Renu @entity1028 ( @entity1028 ) Ancillary Graft (Cook Medical Inc, Bloomington, Ind) provides active proximal fixation for treatment of pre-existing endografts with failed or failing proximal fixation or seal. The purpose of this study was to evaluate the midterm outcomes of treatment with this device. METHODS: From September 2005 to November 2006, a prospective, nonrandomized, multicenter, postmarket registry was utilized to collect physician experiences from 151 cases (89 converters and 62 main body extensions) at 95 institutions. Preoperative indications and procedural and postimplantation outcomes were collected and analyzed. Technical success and clinical success were determined as defined by the Society of Vascular Surgery reporting standards. RESULTS: @entity1 were predominantly male (87%) with a mean age of 77 years. The interval between the original endograft implantation to Renu treatment was 43.4    18.7 months. The indications for treatment were @entity1070 (n = 111), migration (n = 136), or both (n = 94). Technical success was 98.0% with two cases of intraoperative conversion and one case of persistent @entity1070 . The median follow-up for the cohort was 45.0 months (range, 0-56 months; interquartile range, 25.0 months). Overall, 32 cases had treatment failures that included at least one of the following: @entity204 (n = 5), @entity1070 (n = 18), graft infection (n = 1), @entity715 (n = 1), @entity439 >5 mm (n = 9), @entity397 (n = 4), conversion (n = 9, with 7 after 30 days), and migration (n = 1). Overall, the clinical success for the entire cohort during the follow-up period was 78.8% (119/151). CONCLUSIONS: The postmarket registry data confirm that the Zenith Renu @entity1028 Ancillary Graft can be used to treat endovascular repairs that failed due to @entity177 . The salvage treatment with the Renu device had high technical success rate and resulted in clinical success in a majority of @entity1 (78.8%). While failed endovascular repairs can be salvaged, a clinical failure in one of five @entity1 still emphasizes the importance of @entity1 and device selection during initial @entity439 repair to ensure durable success.

title: Midterm outcomes of the Zenith Renu XXXX Ancillary Graft.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1070 :: ('MESH:D057867', 'Disease') :: ['type IA endoleak', 'endoleak', 'type I/III endoleak']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['proximal attachment failures']

entities_list: @entity439 :: ('MESH:D000783', 'Disease') :: ['endovascular aneurysm', 'aneurysm enlargement']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm', 'AAA']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['AAA']


abstract: UNASSIGNED: Pollen grains are well established to be an important cause of @entity1576 . Current pharmacologic therapies for @entity56 do not cure the disease. Allergen specific immunotherapy is the only treatment method which re-directs the immune system away from @entity56 leading to a long lasting effect. The mechanism by which immunotherapy achieves this goal is an area of active research world-wide. The present experimental study was designed to develop an experimental model of @entity55 based on a relevant @entity1 allergen, Alstonia scholaris pollen, and to establish the immunological and cellular features of specific allergen immunotherapy using this same pollen extract. Our results revealed that Alstonia scholaris pollen sensitization and challenge causes eosinophilic @entity32 with mucin hypersecretion. This is associated with increased total IgE, increased expression of Fc  RI on lung mast cells and increased levels of @entity12718 , @entity22538 _ @entity10957 as confirmed by ELISA, in-situ immunofluorescence and FACS assay. Allergen specific immunotherapy reduced @entity32 and also decreased total IgE level, Fc  RI expression, @entity12718 , @entity22538 _ @entity10957 levels. It was further noted that the reduction of these levels was more by intra-nasal route than by intra-peritoneal route. Thus we present a novel animal model of @entity2023 and specific allergen immunotherapy which will pave the way towards the development of better treatment modalities.

title: Specific allergen immunotherapy attenuates XXXX in a rat model of Alstonia scholaris pollen induced airway allergy.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['airway inflammation']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['Alstonia scholaris pollen allergic disease']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['allergic lung inflammation']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic response', 'allergic asthma']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory allergy']

answer: @entity32 :: (MESH:D007249,Disease) :: ['allergic airway inflammation']


abstract: AIM: The aim of this study was to assess the @entity2193 ( @entity2193 ) as biomaterial used in autogenous tooth transplantation. MATERIAL AND METHODS: The study consisted of 3 @entity235 , 5 months old, in which six incisors and six premolars were transplanted to mechanically prepared @entity133 . One group of teeth was transplanted to a recipient bed, with @entity2193 in the root surface. The second groups of teeth were transplanted using saline solution in the root surface. Every week, clinical examinations were done. Nine weeks later, the animals were killed and the specimens decalcified and prepared for histological and imunohistochemical analysis. Periodontal healing was evaluated by undertaking histomorphometric investigation and analyzed using the Mann- Whitney test (P = 0.05). RESULTS: In both groups, all the transplanted teeth survived. Between the experimental groups, there was statistically significant difference in the complete healing (P = 0.004). There was statistically significant difference between the treatment group in the occurrence of inflammatory root resorption (P = 0.015) and the occurrence of replacement root resorption (P = 0.041). CONCLUSIONS: Emdogain gel used on the surface of transplanted teeth improves the occurrence of complete healing and reduces root resorption.

title: The effect of Emdogain gel on periodontal regeneration in autogenous transplanted XXXX 's teeth.

entities_list: @entity235 :: ('9615', 'Species') :: ['beagle dogs']

entities_list: @entity133 :: ('MESH:D002282', 'Disease') :: ['recipient alveolar sockets']

entities_list: @entity2193 :: ('MESH:D003744', 'Disease') :: ['EMD', 'enamel matrix derivative']

answer: @entity235 :: (9615,Species) :: ['dog']


abstract: UNASSIGNED: A distinct seasonal pattern in total and @entity65 rates has been reported. The factors contributing to this pattern have not been fully explored. Seven locations (average total population 71,354,000) were selected where data were available including relatively warm, cold, and moderate temperatures. Over the period 2004 to 2009, there were 2,526,123 all-cause deaths, 838,264 circulatory deaths, 255,273 @entity301 deaths, and 135,801 @entity583 ( @entity583 ) deaths. We used time series and multivariate regression modeling to explore the association between death rates and climatic factors (temperature, dew point, precipitation, barometric pressure), influenza levels, air pollution levels, hours of daylight, and day of week. Average seasonal patterns for all-cause and @entity65 were very similar across the 7 locations despite differences in climate. After adjusting for multiple covariates and potential confounders, there was a 0.49% increase in all-cause death rate for every 1  C decrease. In general, all-cause, circulatory, @entity301 and @entity583 death rates increased linearly with decreasing temperatures. The temperature effect varied by location, including temperature's linear slope, cubic fit, positional shift on the temperature axis, and the presence of circulatory death increases in locally hot temperatures. The variable effect of temperature by location suggests that @entity1 acclimatize to local temperature cycles. All-cause and circulatory death rates also demonstrated sizable associations with influenza levels, dew point temperature, and barometric pressure. A greater understanding of how climate, temperature, and barometric pressure influence cardiovascular responses would enhance our understanding of circulatory and @entity583 deaths.

title: Relation of XXXX Rates to Climate System, Temperature, Barometric Pressure, and Respiratory Infection.

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['STEMI', 'ST-elevation myocardial infarction']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular deaths', 'cardiovascular death']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

answer: @entity65 :: (MESH:D002318,Disease) :: ['Total and Cardiovascular Death']


abstract: BACKGROUND: @entity9 is difficult to treat, and the available options are often inadequate. The expectorant @entity5923 also acts as a strong local anaesthetic and blocks @entity1372 channels about 40 times more potently than @entity3303 . It preferentially inhibits the channel subtype @entity8603 , which is expressed especially in nociceptive C-fibres. In view of the low @entity137 of @entity5923 , it seemed reasonable to try using it for the treatment of @entity9 that failed to respond to other standard options. MATERIAL AND METHODS: The medical records of seven @entity1 with severe @entity9 and @entity158 reduction following topical @entity5923 treatment are reported retrospectively. As standard therapies had not proved sufficient, a topical @entity5923 20   % cream was repeatedly applied by the @entity1 in the area of @entity9 . RESULTS: The reasons for @entity9 were @entity14000 (2   *), @entity4216 , @entity158 , @entity158 , @entity86 and foot @entity16 of unknown origin. The individual mean @entity158 intensity reported was between 4 and 6/10 (NRS), maximum @entity158 at 6-10/10 (NRS). The @entity158 reduction achieved individually following @entity5923 cream was 2-8 points (NRS) within 5-30  min and lasted for 3-8  h. @entity158 attacks were reduced in all five @entity1 presenting with this problem. Four @entity1 with no improvement after @entity3303 5   % and one @entity1 with no response to @entity2951 8   % nevertheless experienced a @entity158 reduction with topical @entity5923 . No @entity1 reported any side effects or skin changes during a treatment that has since been continued for up to 4 years. CONCLUSION: @entity5923 acts as a strong local anaesthetic and preferentially inhibits the nociceptively relevant @entity1372 channel subtype @entity8603 . For the first time, we report below on a relevant @entity158 relief following topical @entity5923 20   % cream in @entity1 with @entity9 . In view of the positive side effect profile, the clinical benefit in @entity1 with @entity158 should be investigated further.

title: Topical XXXX for the treatment of @entity9 : An initial clinical observation. English version.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity2951 :: ('MESH:D002211', 'Chemical') :: ['capsaicin']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative neuralgia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['phantom pain', 'deafferentation pain', 'Pain', 'pain']

entities_list: @entity4216 :: ('MESH:D020422', 'Disease') :: ['mononeuropathy multiplex']

entities_list: @entity14000 :: ('MESH:D051474', 'Disease') :: ['postherpetic neuralgia']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain', 'Neuropathic pain']

entities_list: @entity5923 :: ('MESH:D000551', 'Chemical') :: ['ambroxol', 'Ambroxol']

answer: @entity5923 :: (MESH:D000551,Chemical) :: ['ambroxol']


abstract: AIM: The haemodynamic effects of intravenous @entity1443 have not been systematically investigated. We compared the physiological effects of intravenous @entity2656 -containing @entity1443 , and an equivalent dosage of @entity2656 , and normal saline 0.9% in healthy volunteers. METHODS: We performed a blinded, triple crossover, randomized trial of 24 adult healthy volunteers. @entity1 received i.v. @entity1443 (1  g @entity1443 +3.91  g @entity2656  100  ml(-1) ), i.v. @entity2656 (3.91  g @entity2656  100  ml(-1) ) and i.v. normal saline (100  ml). Composite primary end points were changes in mean arterial pressure (MAP), systolic blood pressure (SBP) and diastolic blood pressure (DBP) measured pre-infusion, during a 15  min infusion period and over a 45  min observation period. Systemic vascular resistance index (SVRI) and cardiac index were measured at the same time points. RESULTS: Infusion of @entity1443 induced a transient yet significant decrease in blood pressures from pre-infusion values ( @entity24858 .85  mmHg, 95% CI -2.6, -1.1, SBP -0.54  mmHg, 95% CI -1.7, 0.6 and @entity44334 .92  mmHg, 95% CI -2.6, -1.2, P  <  0.0001), associated with a transient reduction in SVRI and an increase in cardiac index. Changes were observed, but to a lesser extent with normal saline (MAP -0.15  mmHg, @entity518 .44  mmHg, DBP --0.73  mmHg, P  <  0.0001), but not with @entity2656 (MAP +1.47  mmHg, SBP +4.03  mmHg, DBP +0.48  mmHg, P  <  0.0001). CONCLUSIONS: I.v. @entity1443 caused a transient decrease in blood pressure immediately after infusion. These effects were not seen with @entity2656 or normal saline. The physiological mechanism was consistent with vasodilatation. This study provides plausible physiological data in a healthy volunteer setting, supporting transient changes in haemodynamic variables with i.v. @entity1443 and justifies controlled studies in the peri-operative and critical care setting.

title: The haemodynamic effects of intravenous XXXX ( @entity1443 ) in healthy volunteers: a double-blind, randomized, triple crossover trial.

entities_list: @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol']

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants']

entities_list: @entity1443 :: ('MESH:D000082', 'Chemical') :: ['paracetamol']

answer: @entity1443 :: (MESH:D000082,Chemical) :: ['paracetamol']


abstract: @entity388 ( @entity388 ) is a caloric vestibular areflexia that occurs suddenly, and whose compensation can take several weeks, sometimes several months. Usually these @entity1 are rehabilitated, but the most affected @entity1 (cervical vestibular evoked myogenic potential (cVEMP) absent) have a worse prognosis of @entity2194 . Thanks to symptomatic, videographic and posturographic evaluation tools, we objectify and quantify which factors influence the recovery or more accurately the compensation of this @entity74 . EQUIPMENT AND METHOD: We have colligated 34 observations of @entity388 whose beginning could be precisely dated. These 34 unilateral caloric areflexic @entity1 had a @entity304 ( @entity304 ) with scales (vertigo symptom scale, dizziness handicap inventory, short form 36), an evaluation of the vestibulo-ocular reflex (VOR) (spontaneous nystagmus, head shaking test, mastoid bone skull vibration test, and finally an evaluation of the vestibulo-spinal function (VSF) on a dynamic posturography platform (DPY). On the other hand were evaluated eight elements supposed to influence (influence factors FI) the care and/or the outcome of the treatment (age, cVEMP absent, duration of deficiency, sports and walk practice, rehabilitation of VOR, rehabilitation of VSF, waiting period before application of rehabilitation, vertigo medications treatment). RESULTS: By comparing averages and with a Fischer's exact test, we can show here that the medical treatment, the waiting period before the application of the rehabilitation, the number of rehabilitation sessions or the type of rehabilitation influence only partially the state of health of @entity5013 . The age of the @entity1 and absent cVEMP don't have a major influence either. However, @entity1 with the most important physical activity feel better from a symptomatic point of view, over a long period after the episode. The effect of rehabilitation might be temporary if daily activity is minimal. CONCLUSION: The evaluation of the vestibulo-ocular reflex has long remained the main element for the evaluation of the state of health of @entity388 . But if you use in addition posturography and symptomatic scales to assess the state of health, the @entity5013 considered to be compensated with the VOR will not always be symptomatically compensated. Estimating the functional recovery of @entity5013 can't be limited to estimating or quantifying the VOR. @entity5013 can't be limited to rehabilitating the VOR. Finally we show here that physical activity is probably more necessary than any type of rehabilitation.

title: XXXX : Evaluation and effect of vestibular rehabilitation.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2194 :: ('MESH:D005128', 'Disease') :: ['vestibulo-ocular compensation']

entities_list: @entity304 :: ('MESH:D010302', 'Disease') :: ['SE', 'symptomatic evaluation']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['type of disorder']

entities_list: @entity388 :: ('MESH:D020338', 'Disease') :: ['vestibular neuritis', 'Vestibular neuritis', 'VN']

entities_list: @entity5013 :: ('MESH:D009443', 'Disease') :: ['Rehabilitating neuritis', 'neuritis']

answer: @entity388 :: (MESH:D020338,Disease) :: ['Vestibular neuritis']


abstract: CONTEXT: @entity17211 and chronic subclinical @entity32 in adults are associated with the development of @entity6 and @entity65 . The potential relationship between @entity1254 and @entity32 and its modulation by lifestyle intervention in the pediatric @entity28 population remain unclear. OBJECTIVES: The objectives were to investigate in adolescents 1) the relationship between @entity1254 and @entity28 -related inflammatory factors, C-reactive protein, and @entity36578 ) the effect of a lifestyle intervention on @entity1254 and whether these effects are related to changes in inflammatory factors. RESEARCH METHODS AND PROCEDURES: Twenty-one @entity28 and age-matched lean adolescents (age, 14-18 yr; Tanner stage, > or =IV) were studied cross-sectionally. Fifteen @entity28 adolescents also underwent a randomized, controlled physical activity-behavior-diet-based lifestyle intervention for 3 months. Associations among @entity1254 , fat mass, insulin resistance, and inflammatory factors at baseline as well as after the intervention were assessed. RESULTS: Plasma @entity1254 concentration was lower (P < 0.001) in the @entity28 vs. age-matched lean adolescents. Significant inverse relationships were observed between @entity1254 and inflammatory factors, insulinemia, insulin resistance, and fat mass. Intervention produced a 34% increase in @entity1254 concentration (P = 0.0004) despite negligible weight loss but with reductions in fat mass, @entity3190 , insulin resistance, and inflammatory factors (all P < 0.01). CONCLUSIONS: The data suggest that in adolescents, @entity28 -related @entity17211 is associated with subclinical @entity32 , and a short-term lifestyle intervention augments @entity1254 concentrations. These effects appear to be related to reductions in fat mass and inflammatory factors. Based on our current understanding of @entity1254 physiology, reversal of @entity17211 in @entity28 adolescents may protect against risks for @entity65 and @entity6 .

title: Reversal of XXXX -related @entity17211 by lifestyle intervention: a controlled, randomized study in @entity28 adolescents.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity17211 :: ('MESH:C567258', 'Disease') :: ['hypoadiponectinemia', 'Hypoadiponectinemia']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obese', 'obesity']

entities_list: @entity3190 :: ('MESH:D006946', 'Disease') :: ['hyperinsulinemia']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity28 :: (MESH:D009765,Disease) :: ['obesity']


abstract: The @entity3308 ( @entity3308 ) of the vertebrate embryonic neural tube develops in response to the isthmic organizer (IsO), located at the midbrain-hindbrain boundary (MHB). @entity3308 derivatives are largely missing in mutants affected in IsO activity; however, the potentialities and fate of @entity3308 precursors in these conditions have not been directly determined. To follow the dynamics of @entity3308 maintenance in vivo, we used artificial chromosome transgenesis in @entity3392 to construct lines where egfp transcription is driven by the complete set of regulatory elements of @entity69995 , the first known gene expressed in the @entity3308 area. In these lines, egfp transcription faithfully recapitulates @entity69995 expression from its induction phase onwards. Using the stability of GFP protein as lineage tracer, we first demonstrate that @entity69995 expression at gastrulation is a selective marker of @entity3308 precursor fate. By comparing GFP protein and @entity69995 transcription, we further reveal the spatiotemporal dynamics of @entity69995 expression that conditions neurogenesis progression towards the MHB over time. Finally, we trace the molecular identity of GFP-positive cells in the acerebellar (ace) and no-isthmus (noi) mutant backgrounds to analyze directly @entity28628 and @entity69996 mutant gene activities for their ultimate effect on cell fate. We demonstrate that most @entity3308 precursors are maintained in both mutants but express abnormal identities, in a manner that strikingly differs between the ace and noi contexts. Our observations directly support a role for @entity28628 in protecting anterior tectal and metencephalic precursors from acquiring anterior identities, while @entity69996 controls the choice of @entity3308 identity as a whole. Together, our results suggest a model where an ordered @entity3308 pro-domain is identified at gastrulation, and where cell identity choices within this domain are subsequently differentially controlled by @entity28628 and @entity69996 functions.

title: Tracing of @entity69995 progeny in XXXX transgenics reveals the dynamics of midbrain-hindbrain neurogenesis and maintenance.

entities_list: @entity3308 :: ('MESH:D020295', 'Disease') :: ['midbrain-hindbrain domain', 'MH']

answer: @entity3392 :: (7955,Species) :: ['zebrafish']


abstract: BACKGROUND: The purpose of the study was to examine the @entity158 related health care utilization in @entity1 with @entity239 syndrome. METHODS: In a multicenter study six rheumatological hospitals associated in the rheumatological center of Heidelberg participated. All consecutive @entity1 which fulfilled the @entity12169 -criteria of @entity239 were assessed. Data about @entity158 and related treatments were available from n=259 @entity1 . RESULTS: @entity1 suffered from chronic generalized @entity158 on average for 5 years before being diagnosed as @entity239 . In most of the cases longlasting localized @entity158 symptoms preceeded generalized @entity158 . The spectrum of @entity158 related treatments seems to be wide and arbitrary: 87% took questionable or excessive medication. 86% had some form of physiotherapy and 41% already experienced psychological treatment. 28% of the @entity1 consulted dental surgeons including teeth extraction and 20% underwent multiple orthopaedic surgery. A mean of five different health care professionals were consulted regarding the @entity158 problem. Treatment satisfaction rated by the @entity1 was lowest with pharmacological and highest with psychological treatment and physiotherapy. CONCLUSIONS: The health care-seeking behavior of @entity239 - @entity1 seems to be characterized by a multitude of different treatment attempts. Treatment was often invasive and focused on localized symptoms rather than on the generalized @entity158 . An early confirmation of the diagnosis and a more evidence based treatment is strongly indicated.

title: [Health care utilization in @entity1 with XXXX ( @entity239 )].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity239 :: ('MESH:D005356', 'Disease') :: ['fibromyalgia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'pain syndrome']

answer: @entity239 :: (MESH:D005356,Disease) :: ['Fibromyalgia Syndrome']


abstract: PURPOSE: To report correlation between retinal and @entity1504 and to evaluate pathogenesis of @entity5861 in the @entity3702 ( @entity3702 ). DESIGN: Observational case series. METHODS: Seventy-five @entity1 with apparent nonaccidental head @entity130 consistent with @entity3702 had complete physical examination, complete ophthalmologic examination, neuroimaging by CT or MRI, or both, and skeletal radiographic survey. In this retrospective review, ophthalmoscopic and @entity1504 were correlated. RESULTS: The age of @entity1 ranged from 2 to 48 months (mean - SD, 10.6 +/- 10.4 months). Neuroimaging was abnormal in all 75 cases. Findings included subdural @entity1410 (70 @entity1 , 93%), @entity2657 (33 @entity1 , 44%), @entity510 (12 @entity1 , 16%), vascular @entity1188 (nine @entity1 , 12%), intraparenchymal blood (six @entity1 , 8%), parenchymal contusion (six @entity1 , 8%), and @entity548 (one @entity1 , 1%). Sixty-four (64/75, 85%) @entity1 had @entity989 , mostly (53/64, 82%) confluent multiple @entity548 that were subretinal, intraretinal, and preretinal in 47/64 (74%) and bilateral in 52/64 (81%). No association was found between anatomic site (left, right, or bilateral) of intracranial and retinal findings (McNemar test kappa = -0.026-0.106) or between any of the intracranial findings mentioned above and the following retinal findings: normal or abnormal retinal examination, multiple (>10) or few @entity5861 (< or =10), symmetric or asymmetric retinal findings, or @entity9712 (kappa = -0.127-0.104). Signs of possible @entity428 were not correlated with any @entity989 (kappa = -0.03-0.073). There was no correlation between evidence of impact @entity130 to the head and @entity5861 (kappa = 0.058). Total Cranial @entity130 Score and Total @entity5861 Score, both indicating the severity of injury, were correlated (P =.032). CONCLUSIONS: Our study supports previous observations that the severity of retinal and @entity1504 is correlated in @entity3702 . We cannot support the suggestions that in most @entity1 with @entity3702 retinal @entity548 is caused by sustained elevated intracranial, elevated intrathoracic pressure, direct tracking of blood from the intracranial space, or direct impact @entity130 . The correlation in severity of both eye and head findings may suggest, however, that @entity989 are the result of mechanical shaking forces.

title: Correlation between @entity989 and @entity1504 in the XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['child', 'children', 'patients']

entities_list: @entity2657 :: ('MESH:D001929', 'Disease') :: ['cerebral edema']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding', 'epidural hemorrhage', 'hemorrhages']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['subarachnoid hemorrhage']

entities_list: @entity428 :: ('MESH:D019586', 'Disease') :: ['increased intracranial pressure']

entities_list: @entity3702 :: ('MESH:D038642', 'Disease') :: ['SBS', 'shaken baby syndrome']

entities_list: @entity9712 :: ('MESH:D041441', 'Disease') :: ['retinoschisis']

entities_list: @entity1504 :: ('MESH:D002561', 'Disease') :: ['intracranial abnormalities', 'intracranial injury']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity5861 :: ('MESH:D012166', 'Disease') :: ['Retinal Hemorrhage', 'retinal hemorrhages']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal abnormalities', 'retinal abnormality']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['Trauma', 'trauma']

answer: @entity3702 :: (MESH:D038642,Disease) :: ['shaken baby syndrome']


abstract: BACKGROUND AND PURPOSE: @entity2269 ( @entity2269 ) is a rare, aggressive @entity5 . We report survival rates and @entity137 associated with sequential multimodality treatment including @entity1161 ( @entity1161 ). MATERIAL AND METHODS: Medical records of 32 @entity1 with @entity2269 treated at our institution were reviewed. @entity1 underwent chemotherapy, cytoreductive surgery with hyperthermic intraperitoneal chemoperfusion (HIPEC), followed by @entity1161 with intensity-modulated radiation or volumetric-modulated arc therapy. RESULTS: Median overall survival (OS) was 60months. After 18months of follow-up, 20 @entity1 (62.5%) had disease recurrence and median disease-free survival (DFS) was 10months. Median time to extrahepatic abdominal failure was 19.4months. Factors affecting time to local progression included liver @entity3 at diagnosis, and an interval of greater than 5.6months between diagnosis and HIPEC or greater than 2.1months between HIPEC and @entity1161 . None of these factors altered OS. Grade 3 or higher @entity137 occurred in 84% of @entity1 . CONCLUSIONS: @entity1161 following chemotherapy, surgical cytoreduction and HIPEC is an aggressive treatment for @entity2269 @entity1 and can result in severe side effects. Our median OS of 5years is favorable compared to prior studies, despite a median DFS of only 10months, which may be due to improved salvage therapies.

title: Survival and @entity137 following sequential multimodality treatment including whole abdominopelvic radiotherapy for @entity1 with XXXX .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['malignancy']

entities_list: @entity1161 :: ('MESH:D011832', 'Disease') :: ['whole abdominopelvic radiation therapy', 'WART']

entities_list: @entity2269 :: ('MESH:D058405', 'Disease') :: ['Desmoplastic small round cell tumor', 'DSRCT']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity2269 :: (MESH:D058405,Disease) :: ['desmoplastic small round cell tumor']


abstract: UNASSIGNED: @entity4096 ( @entity4096 ) is a progressive @entity32 . Because of its inflammatory nature, several circulating markers were investigated for predicting disease progression. We aimed to investigate simple inflammatory blood markers as predictors of clinical class and disease severity in @entity1 with @entity4096 . Eighty @entity1 with @entity4096 were divided into three groups according to clinical class (grade 1, 2 and 3) and score of disease severity (mild, moderate and severe). The basic inflammatory blood markers [neutrophil, lymphocyte, mean platelet volume ( @entity6688 ), white blood cell (WBC), platelet, albumin, D-dimer, @entity2002 , @entity2002 to albumin ratio, and neutrophil to lymphocyte ratio] were investigated in each group. Serum neutrophil, lymphocyte, @entity6688 , platelet count, D-dimer and neutrophil to lymphocyte ratio levels were similar among the groups (P>0.05). Although the serum WBC levels were significant in the clinical severity groups (P<0.05), it was useless to separate each severity class. However, albumin, @entity2002 and the @entity2002 to albumin ratio were significant predictors of clinical class and disease severity. Especially, the @entity2002 to albumin ratio was detected as an independent indicator for a clinical class and disease severity with high sensitivity and specificity (75% sensitivity and 87.5% specificity for clinical class and 90% sensitivity and 88.3% specificity for disease severity). Serum @entity2002 and albumin levels can be useful parameters to determine clinical class and disease severity in @entity1 with @entity4096 . Moreover, the @entity2002 to albumin ratio is a more sensitive and specific predictor of the progression of @entity4096 .

title: Simple blood tests as predictive markers of disease severity and clinical condition in @entity1 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease']

entities_list: @entity4096 :: ('MESH:D014689', 'Disease') :: ['Chronic venous insufficiency', 'CVI']

answer: @entity4096 :: (MESH:D014689,Disease) :: ['venous insufficiency']


abstract: UNASSIGNED: Background and study aims: The transnasal endosheath endoscope is a new disposable technology with potential applicability to the primary care setting. The aim of this study was to evaluate the efficacy of transnasal endosheath endoscopy (TEE) for the detection of @entity355 , by comparing the diagnostic accuracy of TEE with that of standard endoscopy. @entity1 and methods: This was a prospective, randomized, crossover study performed in a single tertiary referral center. Consecutive @entity1 undergoing surveillance for @entity355 or referred for diagnostic assessment were recruited. All @entity1 were randomized to undergo TEE followed by standard endoscopy or the reverse. Endoscopy experiences and @entity1 preferences were evaluated using a questionnaire. Endoscopic and histologic diagnosis of @entity355 , and optical image quality of both endoscopic procedures, were compared. Results: A total of 21 of 25 @entity1 completed the study. TEE had sensitivity and specificity of 100% for an endoscopic diagnosis of @entity355 , and of 66.7% and 100%, respectively, for the histologic diagnosis of @entity355 . The mean optical quality of standard endoscopy was significantly better than that of TEE (7.11  0.42 vs. 4.06  0.27; P<0.0001). However, following endoscopy, @entity1 reported a significantly better experience with TEE compared with standard endoscopy (7.05  0.49 vs. 4.35  0.53; P=0.0006), with 60% preferring TEE and 25% preferring sedated standard endoscopy. Conclusions: In this study, TEE had equal accuracy for an endoscopic diagnosis of @entity355 compared with standard endoscopy, at the expense of reduced image quality and a lower yield of intestinal metaplasia on biopsy. TEE was better tolerated and preferred by @entity1 . Hence, TEE needs further evaluation in primary care as an initial diagnostic tool.

title: Pilot randomized crossover study comparing the efficacy of transnasal disposable endosheath with standard endoscopy to detect XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patient', 'patients']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ["Barrett's esophagus"]

answer: @entity355 :: (MESH:D001471,Disease) :: ['Barrett's esophagus']


abstract: @entity2436 has been described in @entity1 with @entity717 ( @entity717 ). These are the first three published cases of @entity2436 in adults older than 50 years of age with @entity717 . They were followed using the KANNER scale and, in one case, @entity1011 phosphokinase (CPK) monitoring. Case 1 is a 67-year-old Caucasian who probably had been having intermittent episodes of undiagnosed @entity2436 withdrawal for many years. His episodes of @entity2146 and @entity146 responded to @entity2934 up to 8   mg/day. Case 2 is a 63-year-old Caucasian male who had probably had undiagnosed @entity2437 episodes since age 25. An @entity2146 episode that rated 88 on Part 2 of the KANNER scale ended within minutes after he received 1   mg of intramuscular @entity2934 . He had no symptom relapses for 4 years after getting stable oral @entity2934 doses (3-8.5   mg/day). Case 3 is a 55-year-old African-American male with severe @entity25878 and @entity1168 (with a pacemaker). He had been "institutionalized" since age 22 and his undiagnosed @entity2437 episodes appeared to have been intermittently present for at least the last ten years. As he became tolerant and experienced symptom relapse, oral @entity2934 was slowly increased (1.5-18   mg/day). Electroconvulsive therapy was ruled out due to his pacemaker.

title: @entity2436 in Older Adult Individuals with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['IDs', 'intellectual disabilities']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['withdrawal behavior']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

entities_list: @entity2146 :: ('MESH:D011595', 'Disease') :: ['agitation']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity2436 :: ('MESH:D002389', 'Disease') :: ['Catatonia', 'catatonia']

entities_list: @entity2437 :: ('MESH:D012560', 'Disease') :: ['catatonic']

entities_list: @entity2934 :: ('MESH:D008140', 'Chemical') :: ['lorazepam']

answer: @entity717 :: (MESH:D009069,Disease) :: ['Intellectual Disabilities']


abstract: OBJECT Gamma Knife radiosurgery (GKRS) is the least invasive treatment option for medically refractory, intractable @entity4254 ( @entity4254 ) and is especially valuable for treating elderly, infirm @entity1 or those on anticoagulation therapy. The authors reviewed @entity158 outcomes and complications in @entity4254 @entity1 who required 3 radiosurgical procedures for recurrent or persistent @entity158 . METHODS A retrospective review of all @entity1 who underwent 3 GKRS procedures for @entity4254 at 4 participating centers of the North American Gamma Knife Consortium from 1995 to 2012 was performed. The Barrow Neurological Institute (BNI) @entity158 score was used to evaluate @entity158 outcomes. RESULTS Seventeen @entity1 were identified; 7 were male and 10 were female. The mean age at the time of last GKRS was 79.6 years (range 51.2-95.6 years). The @entity4254 was Type I in 16 @entity1 and Type II in 1 @entity1 . No @entity1 suffered from @entity15 . Eight @entity1 (47.1%) reported initial @entity158 relief (BNI Score I) following their third GKRS and 8 others (47.1%) experienced at least partial relief (BNI Scores II-IIIb). The average time to initial response was 2.9 months following the third GKRS. Although 3 @entity1 (17.6%) developed new facial @entity409 following primary GKRS and 2 @entity1 (11.8%) experienced new or worsening @entity132 following the second GKRS, no @entity1 sustained additional @entity132 after the third procedure. At a mean follow-up of 22.9 months following the third GKRS, 6 @entity1 (35.3%) reported continued Score I @entity158 relief, while 7 others (41.2%) reported @entity158 improvement (BNI Scores II-IIIb). Four @entity1 (23.5%) suffered recurrent @entity4254 following the third procedure at a mean interval of 19.1 months. CONCLUSIONS A third GKRS resulted in @entity158 reduction with a low risk of additional complications in most @entity1 with medically refractory and recurrent, intractable @entity4254 . In @entity1 unsuitable for other microsurgical or percutaneous strategies, especially those receiving long-term oral anticoagulation or antiplatelet agents, GKRS repeated for a third time was a satisfactory, low risk option.

title: The results of a third Gamma Knife procedure for recurrent XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity132 :: ('MESH:D010468', 'Disease') :: ['sensory disturbances', 'sensory disturbance']

entities_list: @entity4254 :: ('MESH:D014277', 'Disease') :: ['TN', 'trigeminal neuralgia']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['sensory dysfunction']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain', 'complete pain']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['multiple sclerosis']

answer: @entity4254 :: (MESH:D014277,Disease) :: ['trigeminal neuralgia']


abstract: UNASSIGNED: e15034 Background: Data is scarce on prognostic variables determining recurrence and mortality after surgical resection in @entity1 with @entity1358 ( @entity1358 ) and @entity5 @entity715 . METHODS: Retrospective evaluation of the medical records of 132 @entity1 with @entity1358 and @entity5 thrombi treated at Johns Hopkins Hospital (1997-2008) was done. Demographics, @entity5 characteristics, peri-operative variables, complications and course of disease were studied. Uni- and multivariate Cox proportional hazard analysis was done to identify predictors for recurrence, All Cause Mortality (ACM) and Cancer Specific Mortality (CSM). RESULTS: Mean follow up was 31.3 months. 63 (47.7%) @entity1 had @entity8 (group 1), 56 (42.4%) had subdiaphragmatic Inferior Vena Cava (IVC) @entity715 (group 2) while 13 (9.8%) had involvement of IVC above diaphragm or atrial extension (group 3). IVC @entity715 was more common from the right sided @entity5 . @entity3 at presentation was more commonly found in group 2 and with higher @entity5 grade. @entity532 were more common and hospital stay was longer for @entity1 with higher @entity715 levels. Group 2 had larger mean @entity5 size as compared to group 1. No difference in histology, grade, lymph node positivity, concurrent fat and adrenal invasion was found between 3 groups. @entity715 level was not found to be a predictor of recurrence, ACM or CSM. @entity5 size (p=0.044), adrenal invasion (p=0.002) and vascular invasion (p=0.006) were found to be independent predictors for recurrence. On univariate analysis, @entity5 size and grade were found to be prognostic for ACM and CSM. On multivariate analysis, only size (p=0.002, p=0.001) was found to be an independent predictor for ACM and CSM. 5-year Overall Survival was 46.4%, 43.1% and 31.3% for 3 groups respectively. 5-year Cancer Specific Survival (CSS) was 55.5%, 54.0% and 48.5% for 3 groups respectively. The difference between 5-year CSS of non-metastatic compared to metastatic disease (63.4% vs 23.6%) failed to reach significance (p=0.051). CONCLUSIONS: The level of @entity5 @entity715 does not predict recurrence or mortality in @entity1358 . The survival is determined by inherent @entity146 of the @entity5 manifested by @entity5 grade and size at presentation.

title: Determinants of outcomes after resection of XXXX with venous involvement.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal vein thrombus']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['aggressiveness']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'cancer', 'tumors']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['Post-operative complications']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell cancer', 'RCC']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['Metastatic disease']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus', 'Thrombus']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['renal cell cancer']


abstract: UNASSIGNED: Poor adherence to health-related behaviors can have serious health consequences. Cardiac rehabilitation has been documented to have physiological and psychosocial benefits; however, optimizing adherence to exercise in @entity1 with @entity65 is a particular challenge. We recently completed a large, 6-year randomized trial of exercise training in elderly @entity1 with @entity1028 (50-85  years), which provided an opportunity to describe adherence strategies in this unique group of elderly individuals. @entity1 were randomized to exercise therapy or usual care. Using a case-management approach, a combination of center and home-based training was used during which @entity1 trained for up to 3  years. We observed that overall, 84% of subjects in the exercise group completed >= 1  year in the study, achieving a mean energy expenditure of 1,999      1,030  kcals per week. Subjects in the exercise group were more likely to drop out of the study as compared with usual care, though none of the reasons for dropping out were associated with exercise participation (eg, exercise-related injury). Reasons for withdrawal included orthopedic problems, lost physician coverage, time constraints, and @entity1028 repair. Although the groups were matched for @entity1028 size at baseline, there was a trend for more @entity1028 repairs among usual care subjects versus those in the exercise group (12 [17.6%] vs 5 [6.9%], P  =  0.09). The case-managed approach to optimizing adherence used was reasonably successful in achieving a training response (ie, improvement in exercise capacity) in elderly @entity1 with @entity1028 , a group for whom little is previously known regarding the effects of rehabilitation.

title: Exercise adherence in the elderly: Experience with XXXX simple treatment and prevention.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1028 :: ('MESH:D017544', 'Disease') :: ['abdominal aortic aneurysm (AAA) disease', 'AAA']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular disease']

answer: @entity1028 :: (MESH:D017544,Disease) :: ['abdominal aortic aneurysm']


abstract: @entity1 with @entity177 suffer from @entity2132 which are directly the result of the @entity8 , in addition to those dependent on the primary illness leading to the @entity177 . The mechanisms underlying the defective responses in phagocytic cells, lymphocytes and antigen processing are likely due to either failure to adequately eliminate suppressive compounds by the defective kidneys or to improper metabolic processing of the factors by the damaged renal parynchema. That some of the defects are reversed by transplantation and not dialysis suggests that renal parenchymal metabolic activities may be involved, although it is also possible that functioning glomerular cells are capable of filtering substances that membranes are not currently capable of eliminating. The current strategy for dealing with the @entity465 appears to be totally based on developing means to circumvent the defective function. The other approach, correction of the impaired function, cannot be even considered until the mechanisms underlying the defective function of the cells involved in defenses are better delineated. It seems possible that one or a few compounds are pivotal in altering the function of all the affected cell lines, since, with only a small amount of effort, it is possible to relate the dysfunction to abnormal cell membrane functions in phagocytic cells, dendritic cells and lymphocytes. Until the biochemical basis of the dysfunction of all the cell types affected are better defined, such exercises cannot be translated into better management of @entity1 with @entity177 . Proper function of host defenses requires that appropriate cells can properly respond to threats to host viability. For the cells of the immune system (phagocytes and lymphocytes) this means that their response to regulatory molecules be appropriate, that their mobility be normal, that their adherence to substrates be preserved, and that they can generate the appropriate response to the challenge. For neutrophils, for example, it is necessary that they recognize and mobilize appropriately to chemotactic stimuli, that they be able to adhere to and migrate through endothelial lining, that their phagocytic activity be sufficient, and that they can kill and degrade endocytosed particles and generate appropriate secretions. Similar lists of requirements for good function can be generated for any cell type in the immune defense system. @entity5507 , as well as currently available treatments for @entity5507 , directly or indirectly alters the function of all phases of appropriate immune cell function. Defective host responses in @entity5507 have been recognized for decades and there has been considerable effort in the past decade to better define the extent and mechanisms of @entity73 . Despite the multitude of @entity4696 in humoral, cellular, and inflammatory processes, uremic @entity1 who are cared for today, although they remain at higher risk of serious infectious complications, can and do maintain a good quality of life, with most remaining free of @entity281 for years and decades.

title: Immunologic defects and vaccination in XXXX with @entity177 .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal impairment']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['impaired defenses']

entities_list: @entity5507 :: ('MESH:D014511', 'Disease') :: ['uremia', 'Uremia']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['renal failure', 'chronic renal failure']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['major infections']

entities_list: @entity465 :: ('MESH:D007153', 'Disease') :: ['immunodeficiency']

entities_list: @entity2132 :: ('MESH:D006086', 'Disease') :: ['defective host defenses']

entities_list: @entity4696 :: ('MESH:D003865', 'Disease') :: ['major defects']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVES: A delayed @entity64 -like @entity62 has been observed in @entity1 receiving @entity1499 ( @entity1500 ) for @entity1778 . Diffusion-weighted MRI (DWI) may help to distinguish between @entity385 and chemotherapy-related @entity62 . Although conventional MRI correlates have been described for this @entity64 -like syndrome, DWI data are largely unavailable. Our objective is to present a retrospective analysis of the DWI findings in four @entity1 who suffered subacute @entity2359 after intrathecal @entity1500 . DESIGN: We reviewed the medical records of four @entity1 , who were seen by us between July 2000 and February 2004 for sudden onset of a central @entity16 within days of intrathecal @entity1500 . @entity1 underwent standardized MRI within 48 h of symptom onset; MRI included DWI and apparent diffusion coefficient (ADC) maps. RESULTS: DWI of all @entity1 revealed well-demarcated hyperintense @entity62 corresponding to areas of restricted proton diffusion on ADC maps. Lesions exceeded the confines of adjacent vascular territories. Complete resolution of symptoms within 1-4 days was accompanied by normalization of @entity66 . CONCLUSIONS: DWI findings in this cohort seem to reflect cytotoxic @entity2657 suggesting a reversible metabolic derangement, rather than @entity63 , as the basis for this syndrome.

title: Diffusion-weighted MRI correlates of subacute XXXX -related @entity2359 .

entities_list: @entity2657 :: ('MESH:D001929', 'Disease') :: ['edema within cerebral white matter']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['ADC abnormalities']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological syndrome']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['childhood leukemia']

entities_list: @entity1499 :: ('MESH:D008727', 'Chemical') :: ['methotrexate']

entities_list: @entity62 :: ('MESH:D056784', 'Disease') :: ['lesions within the subcortical white matter', 'leukoencephalopathy']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['ischemic stroke']

answer: @entity1499 :: (MESH:D008727,Chemical) :: ['methotrexate']


abstract: BACKGROUND AND STUDY OBJECTIVE: The point prevalence of @entity2488 ( @entity2488 ) is imperfectly associated with current @entity565 , possibly due to changes over time in bronchial responsiveness (BR). To evaluate cross-sectional and longitudinal determinants of BR, a population sample comprising 408 @entity1 and adolescents, aged 7 to 17 years at enrollment, was examined twice, 6 years apart. METHODS: Case history was obtained by interview and questionnaire. BR to inhaled @entity112 , pulmonary function, and skin prick test reactivity were measured using standard techniques. RESULTS: The point prevalence of @entity2488 (the concentration of @entity112 causing a 20% decline in FEV1 <8 mg/mL) declined from childhood to early adulthood (25% and 6%, respectively; p<0.001); and similarly a decline in @entity112 dose-response slope was observed. At both surveys, prechallenge FEV1 percent predicted, @entity565 , and @entity402 , especially @entity402 to @entity6711 ( @entity6711 ), were important determinants for the degree of BR. After adjustment for prechallenge FEV1 percent predicted, no male-female difference was observed in degree of BR. Lower FEV1 percent predicted (p=0.003), @entity565 (p<0.001), higher degree of BR (p=0.003), and @entity402 to @entity6711 (p=0.007) at enrollment predicted a higher degree of BR at the second survey (degree of BR at second survey adjusted for prechallenge FEV1). Furthermore, new @entity565 (p<0.001) and/or @entity402 to @entity6711 (p=0.003) were associated with higher BR at the second survey. Confining the analysis to nonasthmatics showed that subjects with new or persistent @entity402 to @entity6711 had significantly increased BR compared with nonatopic subjects; and, moreover, prechallenge FEV1 percent predicted was significantly correlated with BR. CONCLUSIONS: BR declines from childhood to early adulthood, possibly reflecting the increase in airway caliber. The level of FEV1 and @entity402 , especially to @entity6711 , are important determinants for changes over time in level of BR, also in nonasthmatic subjects.

title: Longitudinal determinants of bronchial responsiveness to inhaled XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity2488 :: ('MESH:D001982', 'Disease') :: ['BHR', 'bronchial hyperresponsiveness']

entities_list: @entity112 :: ('MESH:D006632', 'Chemical') :: ['histamine']

entities_list: @entity6711 :: ('MESH:D008924', 'Disease') :: ['HDM', 'house dust mite']

answer: @entity112 :: (MESH:D006632,Chemical) :: ['histamine']


abstract: HYPOTHESIS: Laparoscopic liver resection for subcapsular @entity157 in @entity1 with @entity409 is associated with lower morbidity than open resections. DESIGN: A case-comparison study. SETTING: A tertiary referral center. @entity1 AND INTERVENTION: From December 1, 1998, to November 30, 2000, 13 @entity1 with @entity409 who underwent laparoscopic resection of @entity157 formed the laparoscopic group (LG). @entity5 were 5 cm or smaller, subcapsular, and located in anterolateral segments (segments II-VI). A control group was created by matching each laparoscopic case with @entity1 identical for @entity409 , @entity5 size, and location and type of hepatectomy who underwent open liver resection. Fourteen @entity1 fulfilled the criteria and formed the open group (OG). MAIN OUTCOME MEASURES: Postoperative mortality and morbidity. RESULTS: One segment or less was resected in 21 @entity1 and 2 in 6 @entity1 . Operative duration and cumulative portal triad clamping times were longer in the LG (267 +/- 79 minutes vs 182 +/- 57 minutes, P =.006; 68 +/- 24 minutes vs 25 +/- 19 minutes, P =.006, respectively). Mortality rates were 0% in the LG and 14% (2/14) in the OG (P =.2). @entity1578 and @entity843 occurred in 8% (1/13) in the LG and 36% (5/14) in the OG (P =.15). Surgical margin was not different in the 2 groups. Three-year survival was significantly higher in the LG (89% vs 55%; P =.04), but 3-year recurrence rates were similar (46% vs 44%). CONCLUSION: Our study suggests that, despite longer operative and clamping times without clinical consequences, the rate of decompensation of @entity409 could be lower after laparoscopy.

title: Laparoscopic liver resection for subcapsular @entity157 complicating XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumors']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['chronic liver disease', 'liver disease']

entities_list: @entity1578 :: ('MESH:D017093', 'Disease') :: ['Postoperative liver failure']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['hepatocellular carcinoma']

answer: @entity409 :: (MESH:D008107,Disease) :: ['chronic liver disease']


abstract: Medications will be always necessary in the treatment of @entity162 . More and more, however, the importance of an adjunctive psychotherapy is emphasized. Numerous controlled therapy trials showed that @entity308 @entity1 can be effectively treated with cognitive behavior therapy (CBT). Therefore a literature search was done to check for the empirical evidence concerning the efficacy of CBT for @entity162 . We conducted a literature search using Medline, PsycINFO, and Psyndex, considering all publications dealing with the topic "psychotherapy and @entity162 " till July 2001. This search resulted in 241 articles. Ten percent of these publications were considered to be controlled trials. Four studies explicitly tested the efficacy of CBT. Compared to standard medical treatment, CBT proved to be efficient concerning symptomatic and functional outcome. However, there remain many questions to be answered, e.g., if there are differential effects on the course of @entity162 and @entity308 and how stable the results will be in the long run.

title: [Cognitive behavioral therapy as supplement to pharmacotherapy of XXXX . What is the empirical basis?].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['manic', 'bipolar affective disorders', 'bipolar disorder', 'bipolar disorders']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['unipolar depressed', 'depressive symptoms']

answer: @entity308 :: (MESH:D003866,Disease) :: ['manic depressive disorders']


abstract: Some @entity134 hormones as well as @entity4082 have been administered to new-born @entity35 (postnatally) or to pregnant @entity35 (prenatally) in order to study the effect on the future gonadal function of the animals born before or after the injection. A single postnatal @entity342 injection in oily solution influences only the female function; @entity172 or the combination of @entity342 and @entity172 are effective in both sexes preventing the ovulation or damaging the testicles. If the hormone is administered in water instead of oil, several injections are necessary in order to obtain an effect. Only the aqueous solution of @entity4082 produces a positive effect even given in a single injection. When a single postnatal injection is effective the same result can be obtained after prenatal administration but only following intraamniotic injection. @entity4082 is an exception to this rule; intraamniotic injection has no effect. These observations permit the following conclusions: 1. It is possible to influence the hypothalamus-hypophysis function not only in the first days of life but already in the prenatal period. 2. As @entity342 damages only the ovary, @entity172 however the gonads of both sexes, the mechanisme of action can not be the same. @entity342 alters the function of the sexual centres in the brain only in the female @entity35 , @entity172 paralyses this function in both sexes. 3. Prenatal injection of hormone is only effective if administered intraamniotically (eliminating in this way the action of the placenta). This proves the important role of the placenta in the metabolisme of the hormones. 4. Other possible consequences of postnatal @entity342 administration as permanent obstruction of the vagina or @entity1184 of the clitoris can be obtained equally by prenatal intraamniotic injection. These phenomena can also occur independent of the avarian processes, being due to direct hormonal action. 5. @entity43 and abscesses are observed with relative frequency especially following @entity172 or @entity4082 -administration. The cause is unknown but we can assume that @entity1457 in the genital area, produced by the hormone, are responsible for the frequency of these phenomena.

title: [Gonadal function of XXXX following pre- or postnatal administration of some hormones (author's transl)].

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Tubo-ovarian inflammation']

entities_list: @entity1184 :: ('MESH:D006984', 'Disease') :: ['hypertrophy']

entities_list: @entity4082 :: ('MESH:D002996', 'Chemical') :: ['Clomiphene', 'clomiphene']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['circulatory disorders']

entities_list: @entity134 :: ('CHEBI:35341', 'Chemical') :: ['steroid']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen', 'Androgen']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: PURPOSE: Definitive surgical treatment of gastric @entity5 such as @entity674 ( @entity674 ) typically involves full-thickness resection of the lesion with normal gastric wall as the margin. This is not readily possible with proximal gastric lesions near the gastroesophageal junction, nor necessary for small incidental lesions. We have employed a combined endoscopic/laparoscopic intraluminal enucleation technique for selected @entity1 and report long-term surveillance following this novel technique. METHODS: Retrospective review of @entity1 who have undergone intraluminal laparoscopic resection from 1994 to 2008. RESULTS: Fifteen @entity1 who underwent intraluminal enucleation were followed up for a median of 61  months. There were eight @entity1 and seven @entity1 with a mean age of 62.1      3.38  years. Eight @entity1 (53  %) underwent endoscopy for @entity360 , six for @entity2210 (40  %), six for @entity417 (40  %), and four for @entity490 (27  %). Eight lesions (53  %) were located in the fundus/ @entity418 : six (40  %) in the body and two (13  %) in the antrum. The mean @entity5 size was 3.5      0.45 (1.5-7.0) cm. @entity75 with benign histologic features predominated. All operations were successfully completed, including full-thickness resections with no conversion to open procedure, major morbidity, or mortality. @entity1939 was accomplished in 14 @entity1 with no local or distant recurrence and no symptomatic follow-up in any @entity1 . CONCLUSION: Enucleation of intact @entity674 can be accomplished with low risk of recurrence when done with a combined endoscopic/laparoscopic intraluminal technique. It should be the preferred approach considered for small, proximal, intraluminal @entity5 .

title: Long-term outcomes of combined endoscopic/laparoscopic intragastric enucleation of presumed gastric XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient', 'men']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'myogenic neoplasms', 'tumors']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['GIST lesions']

entities_list: @entity1939 :: ('MESH:D001766', 'Disease') :: ['Complete endoscopic and endosonographic surveillance']

entities_list: @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia']

entities_list: @entity674 :: ('MESH:D046152', 'Disease') :: ['GISTs', 'gastrointestinal stromal tumors']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding']

answer: @entity5 :: (MESH:D009369,Disease) :: ['stromal tumors']


abstract: INTRODUCTION: Retrievable plastic biliary stents are usually inserted endoscopically. When endoscopic placement fails, radiological percutaneous transhepatic placement is indicated. We report the occurrence of a case of delayed duodenal perforation with @entity733 formation after radiological placement of a plastic stent. To the best of our knowledge, this is the first report of this complication after radiological stenting. CASE PRESENTATION: A 58-year-old Caucasian @entity1 had a mass 30 mm in size in the head of the @entity3883 . He was referred for radiological insertion of plastic biliary stents after a failed endoscopic attempt. The procedure was uneventful, and the @entity1 was discharged. Two weeks after the procedure, the @entity1 presented with an acute abdomen and signs of @entity295 . Computed tomography revealed erosion of the posterior duodenal wall from the plastic stent, and a large retroperitoneal @entity733 . The @entity733 was drained under computed tomography guidance, and the migrated stent was removed percutaneously with a snare under fluoroscopic guidance. Our @entity1 had an uneventful recovery and was discharged after a week. CONCLUSION: Late retroperitoneal duodenal perforation is a very rare but severe complication of biliary stenting with plastic stents. Gastroenterologists, surgeons and radiologists should all be aware of its existence, clinical presentation and management.

title: Perforation and XXXX formation after radiological placement of a retrievable plastic biliary stent.

entities_list: @entity3883 :: ('MESH:D041781', 'Disease') :: ['pancreas and obstructive jaundice']

answer: @entity733 :: (MESH:D000038,Disease) :: ['abscess']


abstract: OBJECTIVE: To investigate the effect of the percentage of free @entity1486 (%fPSA) on @entity263 risk. MATERIALS AND METHODS: We examined serum total PSA (tPSA) and %fPSA annually in a @entity263 -screening cohort between July 2001 and June 2011. @entity1 with tPSA >4.0  ng/mL or tPSA of 2.0-4.0  ng/mL with %fPSA   <=12% were screened as positive and were recommended to undergo a biopsy. The study population consisted of 6368 @entity1 , aged 40-79  years, who had tPSA   <=4.0  ng/mL at initial screening and who subsequently underwent 1 or more screenings. We calculated the cumulative risk and hazard ratio of @entity263 stratified by the initial %fPSA groups as quartiles of @entity263 @entity1 . RESULTS: During a median follow-up of 36  months, 119 @entity1 were diagnosed with @entity263 . The lowest quartile of %fPSA (<13.3%) was associated with a 21.2-fold higher risk of having @entity263 compared with the highest quartile (>22.2%). For the subset with an initial tPSA   <=1.0  ng/mL, all @entity1 diagnosed with @entity5 had an initial %fPSA   <=33.3% (median). For the subset with tPSA >1.0  ng/mL, @entity1 with %fPSA   <=23.0% (median) had significantly higher risk for @entity5 than those with %fPSA >23.0% (P  <.0001). Of the 114 @entity1 with @entity263 in whom pathologic findings were available, 79 (69.3%) had a Gleason score  >= 3  + 4  =  7. CONCLUSION: A low %fPSA is a strong predictor of a subsequent diagnosis of @entity263 among @entity1 with  tPSA levels   <=4.0  ng/mL. Measurement of %fPSA might enhance the detection of high-grade @entity5 that warrants aggressive treatment.

title: Low Percentage of Free XXXX (PSA) Is a Strong Predictor of Later Detection of @entity263 Among Japanese Men With Serum Levels of Total PSA of 4.0  ng/mL or Less.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Men', 'men']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer', 'future prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']

answer: @entity1486 :: (354,Gene) :: ['Prostate-specific Antigen']


abstract: UNASSIGNED: Objective. Chronic nasal carriage of @entity794 (SA) increases the risk of relapse while Rituximab (RTX) is an effective agent for inducing and maintaining remission in @entity1 with @entity2883 with @entity2883 (GPA). We investigated whether B cell depletion and @entity7893 that occur during RTX treatment increase the risk of chronic SA nasal carriage and subsequent disease flares, in GPA @entity1 on long-term RTX maintenance therapy. Methods. Retrospective cohort study from a disease registry involving 29 GPA @entity1 receiving RTX maintenance (median RTX dose of 9 g) during a median period of 49 months. Nasal swabs were collected prior and during RTX for a median of 3 and 9 swabs respectively. Persistent SA nasal carriage was defined with the presence of SA in more than 75% of nasal swabs. Results. SA nasal carriage did not change during RTX (p = 0.297). However, the rate of positive nasal swabs in GPA @entity1 with transient SA nasal carriage during RTX maintenance increased from 0 prior RTX to 0.42 during RTX (p = 0.017). Persistent SA nasal carriage did not increase the risk of relapses (p = 0.844), of @entity7893 (p = 0.122) and of severe @entity281 (p = 0.144), but reduced the risk of @entity281 (p = 0.044). Change in SA carriage status during RTX did not influence the risk of relapses (p = 0.756), hypogammaglobulinamia (p = 0.474) and @entity281 , either severe (p = 0.913) or chronic (p = 0.121). Conclusion. Long-term RTX maintenance therapy in GPA @entity1 did not significantly influence SA nasal carriage status. Persistent SA carriage during long-term RTX treatment did not seem to increase the risk of relapses, but seemed to decrease the risk of @entity7893 associated @entity281 .

title: @entity794 carriage and long-term Rituximab treatment for @entity2883 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infections', 'chronic infections']

entities_list: @entity7893 :: ('MESH:D000361', 'Disease') :: ['hypogammaglobulinemia']

entities_list: @entity2883 :: ('MESH:D014890', 'Disease') :: ['Granulomatosis', 'polyangiitis']

answer: @entity2883 :: (MESH:D014890,Disease) :: ['polyangiitis']