abstract: AIM: To conduct a meta-analysis of all the studies published in literature over the past three decades on the prevalence of @entity2681 in preschool @entity1 . MATERIALS AND METHODS: The Pubmed data base revealed only one systematic review on the prevalence of @entity3356 in @entity1 up to 5 years old. The search included works published from January 1982 to September 2012, using the following combinations of keywords: 1) " @entity2681 " AND " @entity1 "; 2) " @entity2681 in primary dentition"; 3) " @entity6661 "prevalence". The inclusion criteria for papers on @entity3356 were the deciduous dentition observed only on the palatal and buccal sides with the distinction of erosion, @entity6661 . We took into consideration only randomized control trials. We excluded articles not written in English, case reports, historical and forensic studies, in vitro and in vivo studies. In case of doubt and/or when an abstract was not available, the full text copy of the article was examined. The first search on Pubmed revealed 29 articles, the same found in the study of Kreulen [2010], however we selected only multicentric studies focused on @entity1 of age below 5 years old, in which only the primary dentition (D) and only anterior teeth (incisors) were considered. RESULTS: Both forest plot and scatter plot showed the prevalence of @entity2681 in primary dentition, and that older @entity1 had a more severe @entity2681 . CONCLUSION: @entity2681 should be considered a paediatric dentistry pathological entity as well as dental caries, and it can be related to more severe @entity262 such as @entity354 . In addition, taking care of these little @entity1 is important because they might suffer ipersentiveness, and also pulpal pathology caused by the typical structure of deciduous teeth, where the pulp cavity is wide and close to the dentine and the enamel.

title: Meta-analysis of the prevalence of XXXX in primary dentition.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity2681 :: ('MESH:D014077', 'Disease') :: ['dental erosion', 'Dental erosion']

entities_list: @entity3356 :: ('MESH:D057085', 'Disease') :: ['tooth wear']

entities_list: @entity262 :: ('MESH:D034721', 'Disease') :: ['systemic diseases']

entities_list: @entity6661 :: ('MESH:D019217', 'Disease') :: ['attrition and abrasion', 'dental" AND "attrition" AND']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['Gastroesophageal reflux disease']

answer: @entity3356 :: (MESH:D057085,Disease) :: ['tooth wear']


abstract: The Afrotropical pouched @entity19 Saccostomus campestris displays @entity458 in the use of daily torpor; males reluctantly enter torpor. We tested the hypothesis that males may compensate for a limited heterothermic capacity with lower basal and resting metabolic rates relative to females. We also investigated the association between gonadal activity (testosterone) and the propensity for daily torpor. Body temperature and @entity26 consumption were measured at various ambient temperatures and were compared between sexes under ad libitum and restricted-diet treatments. Whereas no significant sex differences were observed in body temperature and @entity26 consumption under ad libitum treatment, there were pronounced differences in heterothermic responses under food restriction. Females employed torpor more frequently and also had lower minimum torpor body temperatures (ca. 25 degrees C) than males (ca. 29 degrees C). @entity251 inhibited torpor in males, whereas the majority of saline-treated animals employed torpor under both ad libitum and restricted-diet treatments. This study demonstrated that the limited capacity of male S. campestris to enter torpor is a consequence of reproductive activity and that opportunistic breeding and the absence of seasonal testes regression compromises the capacity to conserve energy through daily torpor.

title: Reproductive activity influences thermoregulation and torpor in pouched XXXX , Saccostomus campestris.

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual disparity']

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['Testosterone']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: Currently, there is no standardized approach to the management of @entity410 in @entity1 and there are no published practice guidelines for the procurement of neuroimaging. Presented is a 2-year-old female @entity1 who experienced a 3- to 5-minute episode of staring and @entity2133 twitching associated with high fever. On initial presentation, the @entity1 appeared well and had a normal neurological examination. No focus of @entity281 was identified, and she was diagnosed with @entity410 . The @entity1 was discharged home with close neurology and primary care follow-up but returned the following day with @entity1032 , toxic appearance, and right lower @entity425 . Magnetic resonance imaging of the brain revealed left-sided cranial @entity3509 and the @entity1 was managed with antibiotics and surgical drainage. A literature review to answer the question "Do @entity1 with @entity410 require emergent neuroimaging?" yielded a small number of retrospective reviews describing the utility of computed tomography, magnetic resonance imaging and lumbar puncture in the work-up of @entity410 . Current evidence indicates that neuroimaging is not indicated in an otherwise healthy @entity1 who presents with @entity410 if the @entity1 is well appearing and has no evidence of focal @entity51 on examination. As this case demonstrates, however, serious conditions such as @entity693 and @entity867 (though rare) should be considered in the differential diagnosis of @entity410 and physicians should remain aware that the need for neuroimaging and/or lumbar puncture may arise in the appropriate clinical setting.

title: @entity867 Presenting as a XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patient', 'child']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['complex febrile seizures', 'complex febrile seizure', 'febrile seizures']

entities_list: @entity1032 :: ('MESH:D008607', 'Disease') :: ['altered mental status']

entities_list: @entity2133 :: ('MESH:D014987', 'Disease') :: ['unilateral mouth']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['extremity weakness']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity867 :: ('MESH:D001922', 'Disease') :: ['brain abscess']

answer: @entity410 :: (MESH:D012640,Disease) :: ['Complex Febrile Seizure']


abstract: This study was designed to assess the efficacy and safety of two immunosuppressant regimens in kidney transplantation based on the administration of @entity1140 -one of them with @entity1140 , @entity500 , and @entity288 (n=239) and the other with @entity1140 , and @entity288 (n=236). After completing the initial 3-month study, the @entity1 remaining in the study (197 and 195, respectively) were assessed for 3 years. The incidence of @entity697 ( @entity697 ) episodes treated during this period was 28.8% with dual-drug therapy and 29.7% with triple-drug therapy. Late @entity697 : episodes between 4 and 36 months were scarce (3.3% in dual and 4.2% in triple therapy). Chronic rejection incidence was 7.7% and 8.9%, respectively. The @entity1 who experienced @entity697 episodes during the first 3 months developed chronic rejection more frequently than those who did not suffer @entity697 . @entity1 survival at 3 years was 95% vs 95.6%, and graft survival was 86.6% vs 86.5% (NS). Doses and blood levels of @entity1140 were similar in the two groups. Adverse effects were similar among both treatment groups. Median SCr was 123.8 micromol/L vs 114.9 micromol/L in @entity1 who did experience @entity697 : 145.9 micromol/L vs 132.6 micromol/L in those with early @entity697 ; and 194.5 micromol/L vs 152 micromol/L in those who presented with late @entity697 . Need for de novo posttransplant insulin was 4.2% in the dual-drug group and 3.8% in the triple-drug cohort. These results demonstrate that, after 3 years of follow up, there were similar efficacy data among the dual- and triple-drug regimens. Thus, addition of @entity500 does not contribute any advantage in the middle term.

title: Comparison between a two-drug regimen with @entity1140 and steroids and a triple one with XXXX in kidney transplantation: results of a European trial with 3-year follow up.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patient']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute rejection', 'AR']

entities_list: @entity500 :: ('MESH:D001379', 'Chemical') :: ['azathioprine']

entities_list: @entity1140 :: ('MESH:D016559', 'Chemical') :: ['tacrolimus']

entities_list: @entity288 :: ('MESH:D000305', 'Chemical') :: ['corticosteroids']

answer: @entity500 :: (MESH:D001379,Chemical) :: ['azathioprine']


abstract: PURPOSE: A phase II trial investigated the activity and @entity137 of a bolus administration schedule of @entity901 , @entity1487 ( @entity1487 ), and @entity4181 (LV) therapy in @entity1 with untreated advanced @entity14 . @entity1 AND METHODS: Forty-five @entity1 in this multicenter, open, nonrandomized study received @entity901 130 mg/m(2) on the first day of each course and @entity1487 and LV 350 mg/m(2) and 20 mg/m(2), respectively, as a daily bolus for 5 days, every 21 days, for a maximum of six courses. RESULTS: Partial responses occurred in 18 @entity1 , giving an intent-to-treat response rate of 40.0%. Median time to response was 12.7 weeks; median duration of response was 18.4 weeks. Median progression-free survival was 5.9 months; median survival was 14 months. The independent prognostic factors for improved overall survival were good performance status and negative carcino-embryonic antigen blood level. Incidences of adverse effects were reduced after the @entity1487 dose was reduced to 300 mg/m(2). Reversible @entity137 occurred in 44.4% of @entity1 . CONCLUSION: Bolus administration of @entity901 , @entity1487 , and LV as first-line therapy for untreated advanced @entity14 is efficacious and safe. In addition to a more favorable safety profile, the 300 mg/m(2) dosage offered improved dose-intensity compared with the initial dosage.

title: Bolus @entity1487 and @entity4181 with @entity901 as first-line treatment in metastatic XXXX .

entities_list: @entity901 :: ('MESH:C030110', 'Chemical') :: ['oxaliplatin']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity4181 :: ('MESH:D002955', 'Chemical') :: ['leucovorin']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'neurologic toxicity']

entities_list: @entity14 :: ('MESH:D015179', 'Disease') :: ['colorectal cancer']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-FU', 'fluorouracil']

answer: @entity14 :: (MESH:D015179,Disease) :: ['colorectal cancer']


abstract: We report a case of @entity1188 in a 22-yr-old @entity1 , with an 11-yr history of poorly controlled Type 1 @entity6 complicated by laser-treated @entity989 , macroalbuminuria and severe @entity4148 , also affected by @entity7491 , @entity12012 , @entity66 . She was admitted to our Hospital for @entity158 to the left thigh hindering her from walking. The @entity158 had appeared without @entity130 about 2 months before admission, and worsened progressively in spite of anti-inflammatory drugs. Clinical picture (localised tender mass without skin signs of @entity32 in an afebrile @entity1 ) and laboratory data (erythrocyte sedimentation rate 113 mm in 1 hr, fibrinogen 635 mg/dl) suggested the diagnosis of @entity1188 . Magnetic resonance imaging (MRI) confirmed this hypothesis showing a hyperintense area in T2-weighted sequences at adductor muscle group with enhancement after intravenous contrast. Symptoms subsided over the following 4 weeks after bed rest, analgesics, @entity117 and a good glycaemic control. The 3-month follow-up MRI showed total recovery. At hospital admission, the @entity1 presented a very poor glycaemic control ( @entity4051 c 15.5%). After discharge, she started--in order to avoid the weight gain associated with intensive insulin therapy--a daily intense isometric training, undergoing frequent hypoglycaemic episodes. In a few months, in spite of repeated laser treatment, @entity989 progressed to the proliferative stage with bilateral vitreous @entity548 and visual acuity decreased dramatically notwithstanding vitrectomy. This case confirms the association of @entity1188 with poorly controlled long-standing @entity6 with microvascular complications, suggests the possible role of autoimmunity, and underlines the risk of repeated hypoglycaemic episodes and isometric exercise in the progression of @entity989 .

title: @entity1188 associated with multiple autoimmune disorders, XXXX and a catastrophically poor glycaemic control: a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['coeliac disease and polygenic familiar hypercolesterolaemia']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['haemorrhages']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity7491 :: ('MESH:D017098', 'Disease') :: ['IgA deficiency']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['diabetic muscle infarction']

entities_list: @entity4148 :: ('MESH:D001342', 'Disease') :: ['autonomic neuropathy']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinopathy', 'pre-proliferative retinopathy']

entities_list: @entity12012 :: ('MESH:C562768', 'Disease') :: ['autoimmune hypothyroidism']

answer: @entity7491 :: (MESH:D017098,Disease) :: ['IgA deficiency']


abstract: UNASSIGNED: 533 Background: Preclinical data clearly demonstrated that cyclooxigenase activates growth-promoting and anti-apoptotic pathways as well as aromatase. However, data from clinical trial are poor, mainly due to the severe restrictions that the FDA has imposed to the @entity2247 inhibitors in 2004 because of their serious adverse events. METHODS: We designed a phase III, placebo-controlled prospective trial in which postmenopausal @entity5282 positive early @entity0 (EBC) @entity1 were randomized 1:1 to receive @entity13558 (1 mg/die) upfront in combination with placebo or @entity14296 (60 mg/die). Combined treatment was planned for 24 months. @entity1 were allowed to discontinue the @entity14296 or placebo for @entity137 (censored). @entity13558 was continued for 5 years. The primary end-point was the 5-years event free survival (EFS). The secondary end-point was to compare the risk of @entity174 and the muscle-skeletal events in the two groups. Chi-Square tests for categorical data and time to event provided two-sided p values. RESULTS: Since 2003 to 2006 we enrolled 182 @entity1 . A number of 93 @entity1 was enrolled in the treatment arm and N=89 in the control. The median treatment duration was 14 months in ETAN group and 12 in PAN group. A number of 37 @entity1 in the treatment arm and 33 in the control discontinued @entity14296 after the FDA alert on @entity2247 inhibitors. To a 5 years follow-up, the median EFS was 56.9 and 53.14 months [HR: 1.9; 95%CI (1.03 - 3.59), p= .03] in the treatment arm and control, respectively. There were no significative differences in terms of fractures [RR: 0.58, 95%CI (0.14-2.38), p= .45]. @entity925 was significative lower in the treatment arm (50/73) than the control (16/67) [RR: 2.1, 95%CI (1.29-3.43), p= .002]. None of the @entity1 in the treatment arm developed serious adverse event. CONCLUSIONS: Our data demonstrated a small but significative advantage in terms of EFS and muscle-skeletal events when @entity14296 is added to @entity13558 in adjuvant setting. Data are strongly limited from the study drop-out, but the very long follow-up and the absence of major @entity137 encourage larger phase III confirmatory trials.

title: @entity14296 and XXXX in adjuvant early @entity0 : ETAN trial (phase III).

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fracture']

entities_list: @entity14296 :: ('MESH:C422649', 'Chemical') :: ['etoricoxib']

entities_list: @entity13558 :: ('MESH:C090450', 'Chemical') :: ['Anastrozole', 'anastrozole']

entities_list: @entity925 :: ('MESH:D063806', 'Disease') :: ['Muscle-skeletal pain']

entities_list: @entity5282 :: ('3164', 'Gene') :: ['hormone-receptor']

answer: @entity13558 :: (MESH:C090450,Chemical) :: ['anastrozole']


abstract: Various foot structures are thought to influence forefoot plantar pressures during walking. High @entity551 ( @entity551 ) during walking in @entity1 with @entity6 ( @entity6 ) and @entity1897 ( @entity1897 ) can cause skin breakdown. The question addressed by this study is "What are the primary forefoot structural factors that predict regional @entity551 during walking in groups of @entity1 with and without @entity6 and @entity1897 ?" Twenty @entity1 with @entity6 and @entity1897 (mean age 55+/-9 years, 6 female, 14 male, BMI=33+/-8) and 20 @entity1 without @entity6 , matched for gender, age, and BMI were tested. Measures of foot structure were taken from three-dimensional images constructed from spiral X-ray computed tomography. Peak plantar pressure data were recorded during walking. Hierarchical multiple regression analysis was used to predict regional @entity551 at the great toe and five metatarsal heads from selected structural and walking variables. Metatarsal phalangeal joint angle ( @entity85 ) was the most important variable predicting pressure, accounting for 19-45% of the @entity551 variance at five of the six locations in the @entity6 group. Soft tissue thickness, @entity4553 , and forefoot @entity2720 were the most important predictors of @entity551 in the control group. Combinations of structural and walking variables accounted for 47-71% of the variance in the @entity6 group and 52-83% of the variance of @entity551 during walking in the control group. These structural variables, especially @entity85 , should be considered in attempts to develop strategies to reduce excessive forefoot @entity551 that may contribute to skin breakdown or other injury.

title: Forefoot structural predictors of plantar pressures during walking in @entity1 with @entity6 and XXXX .

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus', 'DM']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['PN', 'peripheral neuropathy']

entities_list: @entity4553 :: ('MESH:D006215', 'Disease') :: ['hallux valgus']

entities_list: @entity2720 :: ('MESH:D007592', 'Disease') :: ['arthropathy']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['hammer toe deformity']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['PPP', 'peak plantar pressures']

answer: @entity1897 :: (MESH:D010523,Disease) :: ['peripheral neuropathy']


abstract: OBJECTIVE: To investigate the relationship between awareness of @entity2414 and psychological well-being in a nonclinically @entity308 sample of @entity1 with mild to moderate @entity195 ( @entity195 ). METHODS: Study @entity1 (N  = 104) enrolled through Columbia University Medical Center and the University of Pennsylvania completed clinical and cognitive assessments. @entity1 were rated with regard to their degree of @entity2414 and completed questionnaires relating to their psychological well-being, including mood and quality of life (QOL). Mediating models were used to establish the relationship between awareness, @entity308 , and QOL and to examine potential mediators of awareness and @entity308 , including @entity458 , objective @entity2414 , and negative self-ratings. RESULTS: There was a direct association between @entity2414 and @entity308 mood but not awareness and QOL. However, there was an indirect association between awareness and QOL through @entity308 . Neither @entity458 , @entity2414 , nor negative self-ratings mediated the relationship between awareness and @entity308 . CONCLUSION: Awareness is associated with @entity308 mood in nonclinically @entity308 @entity1 with mild to moderate @entity195 . However, @entity308 mood does not appear to reflect the direct psychological reaction to awareness of @entity2414 . Moreover, awareness has only an indirect association with QOL via @entity308 mood. These results suggest that preserved awareness does not have a direct negative impact on overall psychological well-being in @entity195 .

title: Examining the Pathways between Self-Awareness and Well-Being in Mild to  Moderate XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'Participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressed', 'depression']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', 'Alzheimer disease']

entities_list: @entity2414 :: ('MESH:D008569', 'Disease') :: ['memory loss', 'memory deficits', 'awareness of memory deficits']

answer: @entity195 :: (MESH:D000544,Disease) :: ['Alzheimer Disease']


abstract: PURPOSE: Visual search plays an integral role in many daily activities. This study aimed to determine whether @entity1 with @entity726 are slower than visually healthy age-matched individuals when searching for items in computer displayed images. METHODS: Forty @entity1 were recruited for the study: 20 @entity1 with a clinical diagnosis of @entity726 and 20 age-similar visually healthy control subjects. All @entity1 had visual acuity of 6/12 or better. @entity1 were presented with 20 images with Landolt C symbols and 15 photographic images of everyday scenes on a computer. The time taken by each @entity1 to locate a specified item in each image was recorded. Average search times were calculated across @entity1 and compared between groups. RESULTS: All the @entity1 had @entity227 in both eyes. On average, the @entity1 also differed from control subjects by binocular contrast sensitivity measurements (p = 0.01) and visual acuity (p = 0.003). The @entity1 (mean age = 67 years, S.D.: 10 years) and controls (mean age: 67 years, S.D.: 11 years) were age similar (p = 0.40). The median search time for @entity1 finding target items in photographs of everyday scenes was 15.2 s (interquartile range 9.4-20.6 s) and this was significantly slower than the median time (10.0 s; interquartile range 7.2-10.3 s) taken by the controls (p = 0.007). There was no statistical evidence for a difference in median search times between groups in the Landolt C search task (p = 0.24). CONCLUSION: Some individuals with @entity227 in both eyes find it especially difficult to locate objects in photographs of everyday scenes when compared to visually healthy individuals of a similar age.

title: An exploratory study of visual search performance in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'participant', 'Participants']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field defects', 'glaucomatous visual field defects']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

answer: @entity726 :: (MESH:D005901,Disease) :: ['glaucoma']


abstract: A series of 212 prostate specimens of @entity1 dead between August 2002-August 2004, have been sectioned in consecutive autopsies and subjected to whole mount analysis in purpose to determine the epidemiology of @entity263 in Greece. @entity263 were found in 40 cases (18.8%) most in the peripheral region. In all, 29 of 40 impalpable @entity5 (70.7%) had volume less than 1 cm3. Most of impalpable @entity189 were of favorable (Gleason score 2-4) or intermediate (Gleason score 5 and 6) histological type (55 and 27.7%, respectively) while only five (12.5%) were undifferentiated (Gleason score 7 and 8). In all, 24 (60%) of the 40 impalpable @entity189 were multifocal and consisted of two or more foci, most of small size (<0.5 cm3). Most of the impalpable @entity5 found in this autopsy study were potentially insignificant @entity5 (relatively low volume, favorable or intermediate histological pattern and absence of invasiveness). @entity5436 ( @entity5436 ) coexisted with impalpable @entity189 , in almost half of the @entity5 -positive specimens. There was a positive correlation between @entity5436 foci and coexistent @entity5 foci in most of the cases. Frequency rate and pathological features of both entities show significant variations in medical literature. Since the incidence of @entity263 in Greece is relatively low, and according to our autopsy findings, it is plausible that the frequency of @entity263 in a certain population could be related to the prevalent model of impalpable @entity5 as well as to the frequency and extend of the @entity1613 .

title: Frequency of @entity263 and XXXX in Greek male population: an autopsy study.

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['Impalpable prostate carcinomas', 'impalpable prostate cancer', 'clinical prostate cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

entities_list: @entity1613 :: ('MESH:D011230', 'Disease') :: ['precancerous lesions']

entities_list: @entity5436 :: ('MESH:D019048', 'Disease') :: ['Prostate intraepithelial neoplasia', 'PIN']

answer: @entity1613 :: (MESH:D011230,Disease) :: ['precancerous conditions']


abstract: OBJECTIVES: To report our experience of subacute @entity39 (SANS), an unusual lesion of the minor salivary palatal glands, and to discuss its relationship with @entity39 sialometaplasia (NS). DESIGN: A retrospective review of records for @entity1 with SANS identified between 1996 and 2001. SETTING: @entity4207 center, referral center, and an ambulatory care center. @entity1 : Three @entity1 (1 @entity1 , 2 @entity1 ), aged 22, 23, and 40 years at diagnosis. INTERVENTION: All 3 @entity1 underwent incisional biopsy. MAIN OUTCOME MEASURES: Clinical description of SANS, ability to make the diagnosis preoperatively, clinical evolution, histologic features, and comparison with the much more frequent NS. RESULTS: Three @entity1 presented with a lateral palatal nodule (1 case bilateral, 1 case ulcerated) of 7 to 10 days' duration, 0.8 to 1.0 cm in size, slightly or not painful. No @entity1 was correctly diagnosed prior to undergoing a biopsy. In all 3 cases, the biopsy specimen showed acinic @entity39 surrounded by a dense polymorphous inflammatory infiltrate with @entity194 of ductal cells but no @entity1544 . Healing occurred without any further treatment in up to 3 weeks. No recurrence was observed in 2 cases; 1 @entity1 was lost to follow-up. CONCLUSIONS: SANS is a @entity158 of the palatal salivary glands, easily misdiagnosed preoperatively. The main differences from NS are smaller size of lesion, scarcity of @entity1066 , and absence of @entity1544 . Although initially described as a new autonomous entity, SANS might be an early or minimal form of NS.

title: @entity39 : a form of XXXX sialometaplasia?

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients', 'patient', 'PATIENTS', 'men']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis', 'necrotizing sialadenitis', 'necrotizing']

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity1544 :: ('MESH:D018307', 'Disease') :: ['squamous metaplasia']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['painful spontaneously resolving necrosis']

answer: @entity39 :: (MESH:D009336,Disease) :: ['necrotizing']


abstract: BACKGROUND: Cast immobilisation after successful closed reduction is a standard treatment for displaced extra-articular @entity174 of lower end radius. The position of the wrist during immobilisation is controversial. Immobilisation in dorsiflexion prevents redisplacement after closed reduction. Our aim is to determine the effectiveness of immobilization of wrist in dorsiflexion in such cases and evaluate anatomical and functional outcome. MATERIALS AND METHODS: Study included 54 @entity1 , above 19 years of age with closed extra-articular @entity174 of lower end radius treated conservatively with below elbow cast application. The wrist was maintained in 15   of dorsiflexion during plaster immobilisation. At 24 weeks, functional results were evaluated with subjective symptoms and objective signs, as per modified Demerit Point Score System. Anatomical result was evaluated based on the scheme devised by Lidstrom (1959) and modified by Sarmiento et al. (1980). RESULTS: 76% @entity1 had Excellent to Good subjective symptoms. Out of 42 @entity1 that had residual dorsal angulation of less than 10  , 37 had excellent to good functional outcome. 39 of the 43 @entity1 who had loss of radial length less than 6  mm had excellent to good functional outcome. 40 out of 49 @entity1 having loss of radial angulation less than 9   showed excellent to good functional outcome. Functional result was directly proportional to anatomical outcome. CONCLUSION: Cast immobilization of extra articular @entity174 of lower end radius with wrist in dorsiflexion prevents re-displacement of the fragments resulting in satisfactory anatomical _ functional outcome.

title: Immobilisation of extra-articular distal radius XXXX (Colles type) in dorsiflexion. The functional and anatomical outcome.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: Energy intake restriction reduces bone formation both in protein-energy malnourished @entity1 and in undernourished @entity35 , and such conditions might cause partial or irreversible @entity604 . Because the use of anti-resorptive agents in this situation is seemingly limited, we examined the effect of the anabolic agent, recombinant @entity1 parathyroid hormone (rhPTH(1-84)), on bones in undernourished conditions. First, the osteopenic changes of @entity35 bones with 40% restricted diet for 4 weeks were confirmed. Subsequently, another set of the @entity35 were randomized into four groups and studied for 8 weeks: the freely fed group (control group); the restricted diet, then freely fed group (restriction-ad libitum group); the restricted diet-vehicle-treated group (restriction-vehicle group); and the restricted diet- @entity4727 -treated group (restriction- @entity4727 group). In the restriction-vehicle group, total femoral @entity79 ( @entity79 ) was lower and femoral length was shorter than the control group by 15.4% and 8.1% respectively (P<0.05). In the restriction-ad libitum group, these parameters recovered fully to those of the control group. In the case of intermittent @entity4727 treatment in the persistent undernourished state, the @entity79 of total femur caught up with those of the control or the restriction-ad libitum group. However, the femoral length remained shorter than those of the other groups. Serum @entity9356 was significantly reduced in continuously undernourished @entity35 , whereas it was elevated in the restriction- @entity4727 group. In conclusion, @entity79 of total femur was low in undernourished @entity35 . However, it increased after re-feeding ad libitum or intermittent @entity4727 treatment. We suggest that rhPTH(1-84) may be a possible therapeutic agent for ongoing @entity604 , especially in @entity1 in a chronically undernourished condition.

title: The effects of recombinant XXXX parathyroid hormone, rhPTH(1-84), on bone mass in undernourished @entity35 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'human', 'patients']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: BACKGROUND: Reperfusion causes injury to the coronary artery endothelium primarily by neutrophil-mediated mechanisms. However, factors other than neutrophils may govern the extent of @entity296 . This study tests the hypothesis that gradual initiation of reflow will reduce reperfusion injury and preserve postischemic endothelial function. METHODS: In 16 anesthetized @entity235 , the left anterior descending artery was ligated for 60 minutes. In one group, reperfusion was initiated abruptly (abrupt, n = 8), whereas in the gradual reperfusion group (ramp, n = 8), flow was slowly initiated during the first 30 minutes of reperfusion. After reperfusion, coronary artery segments were isolated to assess postischemic endothelial function. RESULTS: Infarct size (area of @entity39 /area at risk) was significantly reduced in the ramp group (28.2% +/- 2.0%) compared with abrupt (41.6% +/- 1.4%). Neutrophil accumulation ( @entity20402 ) in the area at risk was significantly greater in the ramp group compared with abrupt (8.0 +/- 1.3 versus 3.5 +/- 0.8 U/g tissue). In isolated postischemic left anterior descending arterial rings, the concentration of @entity934 that elicited a response 50% of the maximum possible response was significantly greater in abrupt (-6.88 +/- 0.04 log [mol/L]) than ramp (-7.62 +/- 0.04 log [mol/L]) and control (-7.68 +/- 0.003 log [mol/L]), suggesting @entity409 . The concentration of @entity3365 that elicited a response 50% of the maximum possible response was similarly greater in abrupt (-7.24 +/- 0.03 log [mol/L]) versus ramp (-7.62 +/- 0.03 log [mol/L]) and control (-7.8 +/- 0.04 log [mol/L]). Smooth @entity121 (response to @entity11495 ) also occurred in the abrupt rings. CONCLUSIONS: Gradual reperfusion of an ischemic area reduces @entity1188 size and preserves endothelial function but paradoxically increases neutrophil accumulation within the area at risk.

title: Gradual reperfusion reduces XXXX size and endothelial injury but augments neutrophil accumulation.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial necrosis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['endothelial dysfunction']

entities_list: @entity11495 :: ('MESH:D012977', 'Chemical') :: ['sodium nitrite']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle dysfunction']

entities_list: @entity934 :: ('MESH:D000109', 'Chemical') :: ['acetylcholine']

answer: @entity1188 :: (MESH:D007238,Disease) :: ['infarct']


abstract: UNASSIGNED: Three combinations of molecular chaperones from @entity526 , i.e., DnaK-DnaJ-GrpE- @entity26540 - @entity26541 , @entity26540 - @entity26541 and DnaK-DnaJ-GrpE, were overproduced in @entity13724 , and their in vitro stabilizing effects on a @entity7575 hydratase (NHase) were assessed. The optimal gene-combination, @entity526 @entity26540 - @entity26541 (ecgroEL-ES), were introduced into Rhodococcus ruber TH3. A novel engineered strain, R. ruber TH3G was constructed with the native NHase gene on its chromosome and the heterologous ecgroEL-ES genes in a shuttle plasmid. In R. ruber TH3G, NHase activity was enhanced 37.3% compared with the control, TH3. The in vivo stabilizing effect of ecGroEL-ES on the NHase was assessed using both @entity3323 immersion and heat shock experiments. The inactivation behavior of the in vivo NHase after immersion in a solution of dynamically increased concentrations of @entity3323 was particularly evident. When the @entity3323 concentration was increased to 500 g/L (50%), the remaining NHase activity in TH3G was 38%, but in TH3, activity was reduced to 10%. Reactivation of the in vivo NHases after varying degrees of inactivation was further assessed. The activity of the reactivated NHase was more than twofold greater in TH3G than in TH3. The hydration synthesis of @entity3323 catalyzed by the in vivo NHase was performed with continuous acrylonitrile feeding. The final concentration of @entity3323 was 640 g/L when catalyzed by TH3G compared with 490 g/L @entity3323 by TH3. This study is the first to show that the chaperones ecGroEL-ES work well in Rhodococcus and simultaneously possess protein-folding assistance functions and the ability to stabilize and reactivate the native NHases.

title: Overproduction of the @entity526 chaperones @entity26540 - XXXX in Rhodococcus ruber improves the activity and stability of cell catalysts harboring a @entity7575 hydratase.

entities_list: @entity7575 :: ('CHEBI:18379', 'Chemical') :: ['nitrile']

entities_list: @entity3323 :: ('MESH:D020106', 'Chemical') :: ['acrylamide']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli', 'E. coli']

answer: @entity26541 :: (13876916,Gene) :: ['GroES']


abstract: The present prospective single-center study investigated the prognostic role of novel serum biomarkers in advanced @entity788 ( @entity788 ). @entity1 (pts) with locally advanced or metastatic @entity788 treated with first-line palliative chemotherapy were included. Among others, the serum markers CYFRA 21-1, @entity2104 , @entity5475 ( @entity5475 ), and 25-OH vitamin D3 were determined at baseline and categorized by pre-defined cut-offs [median values (MV), upper limits of normal (ULN), lower limits of normal (LLN), or the natural logarithm (ln)] and correlated with @entity1349 ( @entity1349 ). Among the 59 pts included, pre-treatment CYFRA 21-1 levels showed a strong correlation with @entity1349 independent of the applied cut-off (MV 4.9  ng/ml-14.2 vs. 4.2 months, HR 0.18, p   =   0.001; ULN 3.3  ng/ml-14.2 vs. 4.4 months, HR 0.28, p   =   0.003; [ln] CYFRA 21-1-HR 0.77, p   =   0.013). Lower values of @entity2104 were additionally associated with an improvement in @entity1349 (categorized by LLN of 2.05  g/l-10.4 vs. 5.5 months, HR 0.46, p   =   0.023; [ln] @entity2104 -HR 0.51, p   =   0.036). Pts with baseline @entity5475 values below the MV of 22  mg/l also had a prolonged @entity1349 (10.4 vs. 5.0 months, HR 0.47, p   =   0.036). For 25-OH vitamin D3 levels, no significant correlation with @entity1349 was found. In multivariate analyses, pre-treatment CYFRA 21-1 levels (categorized by MV-HR 0.15, p   =   0.032) as well as [ln] @entity2104 (HR 0.30, p   =   0.006) retained their independent prognostic significance for @entity1349 . CYFRA 21-1, @entity2104 , and @entity5475 might provide useful prognostic information in advanced @entity788 . An external multicenter validation of these results is necessary.

title: Assessing novel prognostic serum biomarkers in advanced @entity788 : the role of CYFRA 21-1, serum amyloid A, XXXX , and 25-OH vitamin D3.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['pancreatic cancer', 'PC']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity2104 :: (3240,Gene) :: ['haptoglobin']


abstract: The accumulation of 125I-low density lipoprotein (LDL) into normal and @entity731 arterial tissue and cellular uptake in arterial cells were studied in an in vitro perfusion system for @entity95 aorta. The accumulation of 125I-LDL in normal tissue could be fitted to an inverse exponential function with an initial influx rate of 1.39 nl/mg wet weight/hour and an equilibration volume of about 2% of the tissue volume. The influx rate into @entity731 was about 10 times faster and the equilibration volume, 50 times higher. In @entity731 tissue there was a steep concentration gradient between the plaque and the underlying media. The accumulation of 125I-LDL in the media under plaque and in normal tissue adjacent to plaques was similar to that seen in normal tissue. For studies of cellular uptake of LDL a trace label, 125I- @entity6114 - @entity8692 (TC), was used. Normal or @entity731 @entity95 aorta was perfused in vitro with medium containing 125I-TC-LDL. After perfusion the tissue was digested and the cells were isolated by density gradient centrifugation. Two main cell fractions with characteristics of smooth muscle cells and foam cells, respectively, were obtained. A 70-fold higher uptake was seen in the foam cells. In conclusion, these studies suggest a higher influx rate into @entity731 , as well as a high LDL concentration in the plaque, compared with normal tissue or underlying media. We suggest that most of the cellular uptake of LDL in the arterial wall is caused by the foam cells.

title: Influx and cellular degradation of low density lipoproteins in XXXX aorta determined in an in vitro perfusion system.

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic', 'atherosclerotic plaques']

entities_list: @entity8692 :: ('MESH:D002475', 'Chemical') :: ['cellobiose']

entities_list: @entity6114 :: ('MESH:D014439', 'Chemical') :: ['tyramine']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: BACKGROUND: Mortality in @entity146 @entity1 both from natural and non-natural causes was reported to be markedly higher than in the general population. The effect of the @entity146 hospital (PH) closure process on mortality has nonetheless seldom been investigated. We studied mortality in a cohort of PH @entity1 , taking into account the closure process in Italy. METHODS: A total of 2915 @entity1 from 12 PH were described in the period 1994-1996 and followed up until June 2000, and discharges and @entity204 were registered. Standardized mortality ratios (SMR) for natural and non-natural causes were computed on the basis of regional death rates. RESULTS: Observed @entity204 were 714 vs. 291.2 expected. The all-causes SMR was 2.47 in males and 2.43 in females. The SMR was 26.92 in males and 13.75 in females for @entity146 causes, 6.84 and 7.89 for undefined causes, 9.57 and 7.27 for @entity55 , 6.38 and 7.78 for @entity1030 , and 1.27 and 1.58 for @entity741 . No excess was observed for all @entity5 in males, but the SMR was 1.50 for @entity2 in males, 2.30 for @entity0 and 1.48 for all @entity5 in females. SMR for suicide was 3.85 in males and 2.73 in females. Most SMR were higher at younger age, although the rate of absolute excess @entity204 was greater above age 60. The SMR for all causes was 2.66 before discharge from PH, and 2.09 after discharge. CONCLUSIONS: Mortality remained high after leaving the PH, but no increase was associated to the PH closure.

title: Mortality in long-stay @entity1 from XXXX hospitals in Italy--results from the Qualyop Project.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonia']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasms', 'cancers']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancer']

entities_list: @entity741 :: ('MESH:D017202', 'Disease') :: ['ischemic heart disease']

entities_list: @entity1030 :: ('MESH:D029424', 'Disease') :: ['chronic obstructive respiratory disease']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: OBJECTIVE: To systematically review evidence for the efficacy of family-based education for @entity712 ( @entity712 ) @entity1 and carers. METHOD: A systematic review was conducted. Databases CINAHL, MEDLINE Complete, Cochrane, PubMed, Web of Science, EMBASE, PsycINFO, and Scopus were searched between 1 January 2005 and 1 May 2015. Randomised controlled trials included @entity712 @entity1 and carer dyads or carers alone. The primary outcome was @entity712 knowledge. Secondary outcomes included self-care behaviour, dietary and treatment adherence, quality of life, @entity308 , perceived control, hospital readmissions, and carer burden. RESULT: Six trials reported in nine papers were included. Wide variation in the quality of the studies was found. Two studies only examined @entity712 knowledge; a significant improvement among @entity1 and carers was reported. Other significant findings were enhanced @entity1 self-care, boosted dietary and treatment adherence, enriched @entity1 quality of life, improved perceived control among @entity1 but not carers, and reduced carer burden CONCLUSION: Modest evidence was found for family-based education among @entity712 @entity1 and carers. Methodological shortcomings of trials signify the need for empirically sound future research. PRACTICE IMPLICATION: Family-based @entity712 education needs to include strategies that are tailored to the @entity712 @entity1 and carer, and sustainable in nature.

title: XXXX family-based education: a systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HF', 'heart failure']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depression']

answer: @entity712 :: (MESH:D006333,Disease) :: ['Heart failure']


abstract: The incidence of @entity293 ( @entity293 ) in 363 adult renal transplant recipients transplanted during the period 1990-96 has been analysed. UTI occurred in 96 @entity1 (26%), most frequently during the first year after transplantation. Female recipients had significantly more UTI than male recipients (49% vs. 14%, p < 0.0001). There was no difference in the incidence of UTI between recipients receiving @entity1707 -tail catheters as ureteral stents or not, the figures being 21% vs. 28%, respectively. Age had no influence on the incidence of UTI. In 341 @entity1 treated with @entity205 the incidence of UTI was 28%, while in 15 @entity1 treated with @entity1140 only 1 @entity1 (7%) had a UTI (ns). The majority of organisms cultured were gram-negative (76%), with approximately 1/3 being @entity526 and 1/5 being Enterococcus and Klebsiella/Enterobacter. The bacterial spectrum was not influenced by the recipient's age. UTI had no effect on the number of rejections, or on graft and @entity1 survival in living donor transplant recipients. No significant difference was found in graft and @entity1 survival rates at 3 yr between @entity1 who had UTI or no UTI.

title: XXXX following renal transplantation.

entities_list: @entity205 :: ('MESH:D016572', 'Chemical') :: ['cyclosporine']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infections', 'UTIs']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity293 :: (MESH:D014552,Disease) :: ['Urinary tract infections']


abstract: OBJECTIVE: To review the effectiveness of interventions targeted at health care professionals and/or the structure of care in order to improve the management of @entity6 in primary care, outpatient, and community settings. RESEARCH DESIGN AND METHODS: A systematic review of controlled trials evaluating the effectiveness of interventions targeted at health care professionals and aimed at improving the process of care or @entity1 outcomes for @entity1 with @entity6 was performed. Standard search methods of the Cochrane Effective Practice and Organization of Care Group were used. RESULTS: A total of 41 studies met the inclusion criteria. The studies identified were heterogeneous in terms of interventions, @entity1 , settings, and reported outcomes. In all studies, the interventions were multifaceted. The interventions were targeted at health care professionals only in 12 studies, at the organization of care only in 9 studies, and at both in 20 studies. Complex professional interventions improved the process of care, but the effect on @entity1 outcomes remained less clear because such outcomes were rarely assessed. Organizational interventions that facilitated the structured and regular review of @entity1 also showed a favorable effect on process measures. Complex interventions in which @entity1 education was added and/or the role of a nurse was enhanced led to improvements in @entity1 outcomes as well as the process of care. CONCLUSIONS: Multifaceted professional interventions and organizational interventions that facilitate structured and regular review of @entity1 were effective in improving the process of care. The addition of @entity1 education to these interventions and the enhancement of the role of nurses in @entity6 care led to improvements in @entity1 outcomes and the process of care.

title: Interventions to improve the management of XXXX in primary care, outpatient, and community settings: a systematic review.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients', 'patient']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

answer: @entity6 :: (MESH:D003920,Disease) :: ['diabetes']


abstract: The goal of this study is to determine the feasibility of intravenous @entity136 and an intraperitoneal @entity902 agent in the treatment of @entity1 with @entity43 . We performed a retrospective chart review of @entity1 with primary, persistent or recurrent @entity43 , who received intravenous @entity136 and an intraperitoneal @entity902 agent. @entity1 received @entity136 (750 mg/m  ) intravenous on days 1 and 8 and @entity900 (100 or 60 mg/m  ) intraperitoneal on day 1 every 21 - 28 days. An alternate regimen was composed of @entity136 (750 mg/m  ) intravenous and @entity3003 (AUC 5) intraperitoneal on day 1 every 21 days. Dose reductions occurred at the discretion of the prescribing physician.Intravenous @entity136 and an intraperitoneal @entity902 agent were administered to 12 @entity1 with advanced primary or recurrent @entity43 . Myelosuppression was the most common @entity137 . Grade 3 or 4 @entity882 , @entity1398 and @entity417 occurred in 7, 8 and 2 @entity1 respectively. Dose reductions were required in 7 of 12 @entity1 . 10 of 12 @entity1 received 6 cycles of the regimen. Treatment was discontinued prior to 6 cycles in 2 of 12 @entity1 secondary to progression in one case and to grade 4 @entity1398 and @entity882 in another.The combination of intravenous @entity136 and an intraperitoneal @entity902 agent appears to be a feasible regimen in @entity1 with @entity43 . The most common @entity137 was myelosuppression, which resulted in dose reductions in almost half of the @entity1 .

title: Feasibility of intravenous @entity136 and an intraperitoneal @entity902 agent in the treatment of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['carboplatin']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['gemcitabine']

answer: @entity43 :: (MESH:D010051,Disease) :: ['ovarian cancer']


abstract: BACKGROUND: We compared the sonographic characteristics of @entity6594 with pathologic findings. METHODS: Information over 10 years was collected on 12 @entity1 (six @entity1 , six @entity1 ; mean age = 47 years) with surgically proven @entity6594 . Clinical data, sonographic features, and histopathologic findings were reviewed. RESULTS: The @entity5 in males were smaller and simpler than those in @entity1 (p < 0.05, Fisher's exact test). Four of the six larger @entity5 (>5 cm) showed mixed-echoic patterns corresponding with pathologically intratumoral @entity548 and @entity39 . Four homogeneously @entity5 had less change in @entity5 composition. Three homogeneously @entity5 had evident fatty changes inside. One @entity5 had a hypoechoic rim, that correlated mostly to the @entity5 itself and compressed @entity409 . Seven of the 12 @entity5 had thin fibrous capsules that were not seen on sonography. CONCLUSION: @entity6594 have variable sonographic appearances depending on changes in the @entity5 . Hypoechoic, hyperechoic, and mixed-echoic patterns represent simple @entity652 , @entity652 with @entity1560 , and @entity548 , respectively, in @entity5 .

title: Sonographic features of XXXX with pathologic correlation.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity1560 :: ('MESH:D005234', 'Disease') :: ['fatty metamorphosis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage', 'hemorrhagic necrosis']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'hypoechoic tumors', 'isoechoic tumor', 'hyperechoic tumors', 'tumors']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver parenchyma']

entities_list: @entity6594 :: ('MESH:C564190', 'Disease') :: ['Hepatic adenomas', 'hepatic adenomas']

answer: @entity6594 :: (MESH:C564190,Disease) :: ['hepatic adenomas']


abstract: OBJECTIVE: Atrial contribution to ventricular filling was studied to assess its role in predicting the future development of @entity955 ( @entity955 ) in @entity1 with severe @entity4794 ( @entity4794 ) and sinus rhythm. DESIGN: Two hundred and eight @entity1 with severe @entity4794 and sinus rhythm were followed up for 1 year. Baseline data were compared between group I (who developed @entity955 at follow-up) and group II (who maintained sinus rhythm). Left atrial size, severity of @entity4794 , @entity1054 ( @entity1054 ) of mitral valve flow and @entity1054 due to atrial systole (A- @entity1054 ) were noted. Percentage contribution of A- @entity1054 to the total @entity1054 (A-%) was calculated. Sensitivity and specificity of A-% to predict the onset of @entity955 was obtained. RESULTS: Left atrial size, severity of @entity4794 and total @entity1054 were similar in the two groups. Group I @entity1 were older (31.1 +/- 9.1 and 18.4 +/- 6.5 years, respectively, p < 0.03) with smaller A- @entity1054 (5.3 +/- 2.2 and 6.7 +/- 3.4 cm, respectively, p < 0.01) and A-% (8.9 +/- 1.8 and 11.2 +/- 2.7, respectively, p < 0.003). A-% of <9% (mean value of A- @entity1054 in group I) had high sensitivity (84%, positive predictive value 76%) and specificity (80%, negative predictive value 87%) to predict the development of @entity955 . CONCLUSION: Atrial contribution to ventricular filling is reduced in @entity1 prone to develop @entity955 (due to inefficient left atrial contraction, much before its dilatation). It can be used for early identification of @entity1 likely to develop @entity955 with high sensitivity and specificity. It is simple, easily available, cost-effective and will guide earlier intervention and more frequent follow-up. There is a preclinical loss in atrial pump function much before the eventual onset of @entity955 .

title: Prediction of @entity955 in XXXX with severe @entity4794 --role of atrial contribution to ventricular filling.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1054 :: ('MESH:D000377', 'Disease') :: ['VTI', 'velocity time integral']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity4794 :: ('MESH:D008946', 'Disease') :: ['MS', 'mitral stenosis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: @entity1851 is the prototype marker of @entity32 and has been shown to predict mortality in hemodialysis @entity1 . However, it remains uncertain as to whether a single @entity1851 level has similar prognostic significance in peritoneal dialysis @entity1 . A single high-sensitivity @entity1851 (hs-CRP) level was measured in 246 continuous ambulatory peritoneal dialysis @entity1 without active infections at study baseline together with indices of dialysis adequacy, echocardiographic parameters (left ventricular mass index, left ventricular dimensions, and ejection fraction), nutrition markers (serum albumin, dietary intake, and subjective global assessment) and biochemical parameters (hemoglobin, lipids, @entity460 , and @entity1391 ). The cohort was then followed-up prospectively for a median of 24 mo (range, 2 to 34 mo), and outcomes were studied in relation to these parameters. Fifty-nine @entity1 died (36 from cardiovascular causes) during the follow-up period. The median hs-CRP level was 2.84 mg/L (range, 0.20 to 94.24 mg/L). @entity1 were stratified into tertiles according to baseline hs-CRP, namely those with hs-CRP < or = 1.26 mg/L, 1.27 to 5.54 mg/L, and > or = 5.55 mg/L. Those with higher hs-CRP were significantly older (P < 0.001), had greater body mass index (P < 0.001), higher prevalence of @entity453 (P = 0.003), and greater left ventricular mass index (P < 0.001). One-year overall mortality was 3.9% (lower) versus 8.8% (middle) versus 21.3% (upper tertile) (P < 0.0001). @entity65 rate was 2.7% (lower) versus 5.2% (middle) versus 16.2% (upper tertile) (P < 0.0001). Multivariable Cox regression analysis showed that every 1 mg/L increase in hs-CRP was independently predictive of higher all-cause mortality (hazard ratio [ @entity712 ], 1.02; 95% CI, 1.01 to 1.04; P = 0.002) and @entity65 ( @entity712 , 1.03; 95% CI, 1.01 to 1.05; P = 0.001) in peritoneal dialysis @entity1 . Other significant predictors for all-cause mortality included age ( @entity712 , 1.07; 95% CI, 1.04 to 1.10), gender ( @entity712 , 0.49; 95% CI, 0.27 to 0.90), @entity731 ( @entity712 , 2.65; 95% CI, 1.46 to 4.80), left ventricular mass index ( @entity712 , 1.01; 95% CI, 1.00 to 1.01) and residual GFR ( @entity712 , 0.53; 95% CI, 0.38 to 0.75). Age ( @entity712 , 1.06; 95% CI, 1.02 to 1.10), history of @entity712 ( @entity712 , 3.31; 95% CI, 1.36 to 8.08), @entity731 ( @entity712 , 3.20; 95% CI, 1.43 to 7.13), and residual GFR ( @entity712 , 0.57; 95% CI, 0.38 to 0.86) were also independently predictive of @entity65 . In conclusion, a single, random hs-CRP level has significant and independent prognostic value in @entity1726 @entity1 .

title: Is a single time point XXXX predictive of outcome in peritoneal dialysis @entity1 ?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['HR', 'heart failure']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic vascular disease']

entities_list: @entity1391 :: ('CHEBI:26020', 'Chemical') :: ['phosphate']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity65 :: ('MESH:D002318', 'Disease') :: ['cardiovascular mortality', 'Cardiovascular death']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['C-reactive protein']

answer: @entity1851 :: (1401,Gene) :: ['C-reactive protein']


abstract: UNASSIGNED: @entity12464 ( @entity12464 ) are an infrequent cause of @entity1353 in oncological @entity1 . The majority are di-agnosed in @entity1 with advanced @entity5 , above all localized in the breast, lung or stomach. There are few published cases involving @entity1 with @entity5 . We present the case of a 69 year-old male, without a previous diagnosis of @entity5 , who was admitted due to subacute @entity1353 , with clinical suspicion of @entity1151 ( @entity1151 ). The @entity1 died on the fifth day of admission. The autopsy confirmed the existence of a @entity5 in the left renal pelvis with hepatic and lymphoganglionary metastasis and an extensive @entity1151 that affected a large part of the capillaries and medium-caliber blood vessels of both lungs. @entity12464 were considered responsible for the progressive @entity1576 and as the final cause of @entity204 . The most frequent clinical presentation of @entity12464 is @entity1353 . They are often mistaken for @entity1151 and diagnosis is not easy. Their prognosis is very bad, with extremely high mortality and confirmation is usually post-mortem.

title: [Microvascular XXXX in a @entity1 with @entity5 ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'urothelial tumors', 'tumors']

entities_list: @entity12464 :: ('MESH:D009360', 'Disease') :: ['Pulmonary tumor embolisms', 'PTE']

entities_list: @entity1151 :: ('MESH:D011655', 'Disease') :: ['PT', 'microvascular pulmonary embolism', 'pulmonary thromboembolism']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

answer: @entity12464 :: (MESH:D009360,Disease) :: ['pulmonary tumor embolism']


abstract: UNASSIGNED: @entity1778 stem cells (LSCs) are regarded as the origin of @entity1778 and its recurrence. Side population (SP) cells possess some intrinsic stem cell properties and contain numerous LSCs. In this study, we examined the prognostic significance of cluster differentiation 47 (CD47) and identified the appropriate target for eliminating LSCs. We determined the percentage of SP cells in a @entity1357 cell population and analyzed CD47 expression in different cell subsets. We then explored whether CD47 affected the phagocytic ability of macrophages to LSCs in vitro. Finally, the effect of anti-CD47 monoclonal antibodies, alone or combination with @entity2592 , against @entity1778 cells was evaluated in vitro and in vivo to identify the optimal targets for the treatment of @entity1778 . We observed an SP sub-fraction at low frequency (1.81    0.99%), which was a likely candidate for LSC enrichment. CD47 was more highly expressed on @entity1357 LSCs (P < 0.05) and was an independent predictor of survival and refractory disease in @entity1357 -engrafted @entity19 . Furthermore, the anti-CD47 monoclonal antibody stimulated preferential phagocytosis of LSCs by macrophages in vitro. Finally, single or combination treatment of @entity1357 LSC-engrafted @entity19 with @entity2592 and anti-CD47 antibody resulted in targeting of LSCs and depletion of @entity1778 cells. These findings suggest that CD47 is an antibody target in LSCs and combination treatment with @entity2592 and anti-CD47 monoclonal antibody represents an attractive option for the therapeutic targeting of @entity9020 .

title: @entity2592 and anti-CD47 antibody combination therapy eliminates XXXX @entity1357 cells in vivo and in vitro.

entities_list: @entity9020 :: ('MESH:D007948', 'Disease') :: ['acute monocytic leukemia']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['Leukemia', 'leukemia', 'leukemic']

answer: @entity9020 :: (MESH:D007948,Disease) :: ['acute monocytic leukemia']


abstract: UNASSIGNED: Conditions such as @entity309 ( @entity309 ) and @entity1691 ( @entity1691 , such as @entity5144 , PsA, and @entity1691 , @entity5427 ) are characterized by an imbalance between osteoclast (OC) bone resorption and osteoblast (OB) bone formation. The two conditions present substantial differences in bone involvement, which is probably related to the different expression of @entity4155 and @entity310 , two cytokines that strongly promote osteoclastogenesis and focal @entity79 . @entity310 is the major inflammatory cytokine in @entity309 . It acts by both triggering OC bone erosion via the @entity5298 system, and suppressing OB bone formation through the overexpression of @entity5741 , a powerful inhibitor of the WNT bone anabolic signaling pathway. Differing from @entity310 , @entity4155 promotes also osteogenesis, particularly at inflamed sites undergoing mechanical stress, such as entheses. Therefore, in @entity309 , where overexpression of @entity310 is higher than @entity4155 , OC bone resorption largely prevails upon bone formation. In PsA and @entity5427 , the prevailing inflammatory cytokine is @entity4155 , which promotes also osteogenesis. Given the prevalent involvement of entheses poor of OC, excess bone formation may even prevail over excess bone resorption. The results of clinical trials support the different pathophysiology of bone involvement in chronic @entity625 . Inflammation control through anti- @entity310 agents has not resulted in incomparable effects on radiographic progression and excess bone formation in both @entity5427 and PsA. Clinical trials investigating @entity4155 inhibitors, such as secukinumab, in @entity1 with @entity5144 are underway. The preliminary results on @entity32 and symptoms appear positive, while long-term studies are required to demonstrate an effect on excess bone formation.

title: Focal bone involvement in inflammatory @entity625 : the role of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity625 :: ('MESH:D001168', 'Disease') :: ['arthritis']

entities_list: @entity5144 :: ('MESH:D015535', 'Disease') :: ['psoriatic disease', 'psoriatic arthritis']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone erosions']

entities_list: @entity1691 :: ('MESH:D013167', 'Disease') :: ['ankylosing spondylitis', 'spondyloarthritis', 'SpA']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity4155 :: (3605,Gene) :: ['IL17']


abstract: OBJECTIVE: @entity19372 ( @entity19372 ) is a disorder characterized by tubular dilation of renal collecting ducts and cystic dilation of medullary pyramids that has been associated with stone disease. The significance of @entity1790 and the mechanisms by which it occurs are incompletely understood. We describe clinical and metabolic features of @entity1790 in a cohort of @entity1 with @entity19372 . METHODS: Records were reviewed of 56 @entity1 , all with radiographic diagnosis of @entity19372 and data collected pertaining to presentation, stone events and recurrences, stone composition, and metabolic profile to perform a descriptive study with median 3.7 years follow-up. RESULTS: @entity1790 was confirmed radiographically in 39/56 @entity1 (69.6%). No @entity1 without evidence of @entity1790 developed a stone event, whereas 13/39 (33%) of those with @entity1790 developed a recurrent stone event. Stones were composed of @entity3835 , @entity3835 , @entity78 apatite, and @entity414 . Metabolic profile was obtained for 26 of 39 (67%) stone-forming @entity1 demonstrating abnormalities in 22/26 (84.6%). These included @entity5200 , 58% (15/26); low urine volume, 35% (9/26); hyperuricosuria, 27% (7/26); hypocitraturia, 19% (5/26); elevated urine @entity1372 , 15% (4/26); and @entity5201 , 12% (3/26). CONCLUSION: Many @entity1 with @entity19372 have no evidence of @entity1790 . Among those who do, recurrence is common, and metabolic profile and composition are varied as in the general stone-forming population.

title: XXXX in @entity19372 : evaluation of clinical and metabolic features.

entities_list: @entity5201 :: ('MESH:D006959', 'Disease') :: ['hyperoxaluria']

entities_list: @entity3835 :: ('MESH:D002129', 'Chemical') :: ['calcium oxalate monohydrate', 'calcium oxalate dihydrate']

entities_list: @entity19372 :: ('MESH:D007691', 'Disease') :: ['MSK', 'Medullary sponge kidney', 'medullary sponge kidney']

entities_list: @entity78 :: ('MESH:C020243', 'Chemical') :: ['calcium phosphate']

entities_list: @entity1790 :: ('MESH:D053040', 'Disease') :: ['Nephrolithiasis', 'nephrolithiasis']

entities_list: @entity5200 :: ('MESH:D053565', 'Disease') :: ['hypercalciuria']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

answer: @entity1790 :: (MESH:D053040,Disease) :: ['Nephrolithiasis']


abstract: BACKGROUND: Prognostic predictions in @entity4281 ( @entity4281 ) are usually based on relapse and @entity3 . Thus, assessment of factors associated with @entity3 and clinical outcomes in @entity1 with @entity4281 are of significant important. The purpose of this study was to investigate the correlated factors for @entity3 and prognosis for @entity1 with @entity4281 . METHODS: We analyzed 159 @entity4281 @entity1 who underwent curative surgery at the First Teaching Hospital of Xinjiang Medical University from February 2003 to December 2013 by @entity1710 and @entity1711 (HE) staining. Immunohistochemistry (IHC) staining for @entity1759 was performed in 159 @entity4281 and adjacent normal liver specimens. The clinicopathological parameters were analyzed for @entity3 and prognosis, including gender, age, size, @entity730 , @entity39 , foreign body @entity738 and @entity1759 protein level. RESULTS: The rate of @entity3 was 22.1%. Chi-square test showed that low levels of @entity1759 was associated with @entity3 (P = 0.004). However, multivariate analysis suggested that @entity1759 expression is not independent prognostic indicators for overall survival (P = 0.356). In addition, no correlations between prognosis and gender, age, size, @entity730 , @entity39 , foreign body granulomatous, @entity3 were identified. CONCLUSIONS: The finding that a low level of @entity1759 is associated with @entity3 in @entity4281 @entity1 . At present, it thus remains question whether @entity1759 expression is a valid prognostic marker for @entity4281 , further investigations are required.

title: Metastatic and prognostic factors in XXXX with @entity4281 .

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granuloma']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcification']

entities_list: @entity1710 :: ('MESH:D006416', 'Chemical') :: ['hematoxylin']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity4281 :: ('MESH:C536591', 'Disease') :: ['AE', 'alveolar echinococcosis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Access to "safe" water and "adequate" sanitation are emphasized as important measures for @entity2040 control. Indeed, the schistosomes' lifecycles suggest that their transmission may be reduced through safe water and adequate sanitation. However, the evidence has not previously been compiled in a systematic review. METHODOLOGY: We carried out a systematic review and meta-analysis of studies reporting schistosome infection rates in @entity1 who do or do not have access to safe water and adequate sanitation. PubMed, Web of Science, Embase, and the Cochrane Library were searched from inception to 31 December 2013, without restrictions on year of publication or language. Studies' titles and abstracts were screened by two independent assessors. Papers deemed of interest were read in full and appropriate studies included in the meta-analysis. Publication bias was assessed through the visual inspection of funnel plots and through Egger's test. Heterogeneity of datasets within the meta-analysis was quantified using Higgins' I2. PRINCIPAL FINDINGS: Safe water supplies were associated with significantly lower odds of @entity2040 (odds ratio (OR)=0.53, 95% confidence interval (CI): 0.47-0.61). Adequate sanitation was associated with lower odds of @entity380 , (OR=0.59, 95% CI: 0.47-0.73) and @entity4114 (OR=0.69, 95% CI: 0.57-0.84). Included studies were mainly cross-sectional and quality was largely poor. CONCLUSIONS/SIGNIFICANCE: Our systematic review and meta-analysis suggests that increasing access to safe water and adequate sanitation are important measures to reduce the odds of schistosome infection. However, most of the studies were observational and quality was poor. Hence, there is a pressing need for adequately powered cluster randomized trials comparing schistosome infection risk with access to safe water and adequate sanitation, more studies which rigorously define water and sanitation, and new research on the relationships between water, sanitation, hygiene, @entity1 behavior, and schistosome transmission.

title: The Relationship between Water, Sanitation and XXXX : A Systematic Review and Meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'people']

entities_list: @entity4114 :: ('6185', 'Species') :: ['Schistosoma haematobium']

entities_list: @entity380 :: ('6183', 'Species') :: ['Schistosoma mansoni']

entities_list: @entity2040 :: ('MESH:D012552', 'Disease') :: ['schistosomiasis']

answer: @entity2040 :: (MESH:D012552,Disease) :: ['Schistosomiasis']


abstract: OBJECTIVE: To evaluate longitudinal @entity1 -oriented outcomes in @entity1897 over a 14-year time period including time before and after diagnosis. METHODS: The 1996-2007 @entity283 ( @entity283 )-Medicare Claims linked database identified incident @entity1897 cases (ICD-9 codes) in @entity1 >= 65 years. Using detailed demographic information from the @entity283 and Medicare claims, a propensity score method identified a matched control group without @entity16 . @entity1 -oriented outcomes, with an emphasis on self-reported falls, @entity158 , and self-rated health ( @entity283 interview), were determined before and after @entity16 diagnosis. Generalized estimating equations were used to assess differences in longitudinal outcomes between cases and controls. RESULTS: We identified 953 @entity1897 cases and 953 propensity-matched controls. The mean (SD) age was 77.4 (6.7) years for cases, 76.9 (6.6) years for controls, and 42.1% had @entity6 . Differences were detected in falls 3.0 years before @entity16 diagnosis (case vs control; 32% vs 25%, p = 0.008), 5.0 years for @entity158 (36% vs 27%, p = 0.002), and 5.0 years for good to excellent self-rated health (61% vs 74%, p < 0.0001). Over time, the proportion of fallers increased more rapidly in @entity16 cases compared to controls (p = 0.002), but no differences in @entity158 (p = 0.08) or self-rated health (p = 0.9) were observed. CONCLUSIONS: In older @entity1 , differences in falls, @entity158 , and self-rated health can be detected 3-5 years prior to @entity1897 diagnosis, but only falls deteriorates more rapidly over time in @entity16 cases compared to controls. Interventions to improve early @entity1897 detection are needed, and future clinical trials should incorporate falls as a key @entity1 -oriented outcome.

title: Longitudinal XXXX -oriented outcomes in @entity16 : Importance of early detection and falls.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient', 'persons']

entities_list: @entity283 :: ('OMIM:603663', 'Disease') :: ['HRS', 'Health and Retirement Study']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neuropathy']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: Excess @entity1386 is frequent after childhood @entity981 treated without BMT. We measured the whole-body percent fat by dual-energy X-ray absorptiometry and the body-mass index (weight/height(2) (kg/m(2)), BMI) in 25 survivors of childhood @entity1778 or @entity706 (21 with @entity981 ) who had received TBI and allogeneic BMT a median of 8 years ago (range 4-13). Adjusted for sex and age, the mean BMI was slightly but significantly reduced (0.4 s.d. below predicted) and the whole-body percent fat was significantly increased compared with healthy controls (1.1 s.d. above predicted). Eleven of 25 @entity1 had a percent fat above the 90 percentile of the reference values, which indicates excess @entity1386 . Adjusted for sex and age, a higher percent fat was related to additional cranial irradiation. Controlled for this, the whole-body percent fat seemed to be unrelated to age at BMT, length of follow-up, and previous chemotherapy. Compared with untransplanted @entity981 survivors treated with cranial irradiation, BMT survivors had significantly reduced BMI but similar whole body percent fat. BMI was a poor measure of body @entity1386 in these @entity1 . In conclusion, survivors of BMT for childhood @entity1778 or @entity706 are adipose and slightly underweight and consequently have a substantially reduced lean body mass.

title: Degree of @entity1386 after allogeneic BMT for childhood XXXX or @entity706 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity1778 :: ('MESH:D007938', 'Disease') :: ['leukaemia']

answer: @entity1778 :: (MESH:D007938,Disease) :: ['leukaemia']


abstract: UNASSIGNED: Previous studies reported inconsistent findings about the relationship between pretreatment @entity1148 and survival in @entity1 with @entity5 . This study aimed to evaluate the prognostic significance of @entity1148 in @entity5 . We searched databases to identify relevant articles. Pooled hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were calculated. Fourteen studies including 3,394 @entity1 were eligible for the meta-analysis. Overall, an @entity1423 was significantly associated with inferior overall survival (OS, hazard ratio [HR]: 1.66, 95% confidence interval [CI]: 1.42-1.95, P < 0.001) and recurrence-free survival (RFS, HR: 1.67, 95% CI: 1.15-2.42, P = 0.007) but not progression-free survival (PFS, HR: 1.21, 95% CI: 0.89-1.64; P = 0.235). The results were similar for low stage @entity1 treated with surgery alone. Moreover, a pretreatment @entity1148 status was significantly associated with higher clinical stage (odd ratio [OR]: 2.39, 95% CI: 1.68-3.38, P < 0.001), positive pelvic node status (OR: 1.58, 95% CI: 1.01- 2.45, P = 0.044) and larger @entity5 size (OR: 2.32, 95% CI: 1.39-3.87, P = 0.001). Pretreatment @entity1148 is an independent prognosis predictor in @entity5 @entity1 . It may be used as a readily available biomarker to refine clinical outcome prediction for @entity5 @entity1 .

title: The association of pretreatment @entity1148 with prognosis and clinicopathological significance in XXXX : a systematic review and meta-analysis.

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocytosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cervical cancer']

entities_list: @entity1423 :: ('MESH:D001791', 'Disease') :: ['elevated platelet count']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cervical cancer']


abstract: UNASSIGNED: Weissella spp. are non-spore forming, catalase-negative, gram-positive coccobacilli. They are often misidentified by traditional and commercial phenotypic identification methods as Lactobacillus spp. or Lactobacillus-like organisms. Weissella spp. were previously grouped along with Lactobacillus spp., Leuconostoc spp., and Pediococcus spp. Utilization of more sensitive methods like DNA sequencing or Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) has facilitated identification of Weissella as a unique genus. Nineteen species have been identified to date. W. confusa, @entity26043 , and W. viridescens are the only species isolated from @entity1 . The true prevalence of Weissella spp. continues to be probably underestimated. Weissella spp. strains have been isolated from a wide range of habitats including raw milk, feces, fermented cereals, and vegetables. Weisella is believed to be a rare cause of usually nonfatal infections in @entity1 , and is often considered a contaminant. However, in recent years, Weissella spp. have been implicated in @entity2259 , @entity281 , and @entity884 . Alterations of the gut flora from surgery or chemotherapy are believed to facilitate translocation of Weissella spp. due to disruption of the mucosal barrier, predisposing the host to infection with this organism. Implications of the isolation of Weissella spp. from blood must be interpreted in context of underlying risk factors. Weissella spp. are inherently resistant to @entity2176 . Therefore, early consideraton of the pathogenic role of this bacteria and choice of alternate therapy is important to assure better outcomes.

title: Identification and significance of XXXX .

entities_list: @entity2176 :: ('MESH:D014640', 'Chemical') :: ['vancomycin']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['abscesses, prosthetic joint infections']

entities_list: @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['infective endocarditis']

answer: @entity281 :: (MESH:D007239,Disease) :: ['Weissella species infections']


abstract: BACKGROUND: Mucopolysaccharidoses (MPS) are @entity74 caused by deficiency of required glycosaminoglycans breakdown enzymes, inducing @entity299 . Little is known about myocardial deformation involvement in MPS. Our aim was to assess biventricular structure and function in asymptomatic children with MPS using standard echo Doppler and 2D speckle tracking (STE). METHODS: Fifteen MPS children (one type I, six type II, three type III A, one III B, three IV A, one VI), asymptomatic for cardiac symptoms, and 15 age and sex-matched healthy controls underwent echo Doppler and STE. Left ventricular (LV) wall thicknesses, diameters, and mass were normalized by z-score. @entity1002 (GLS), global circumferential strain (GCS), global radial strain (GRS) at papillary muscles, LV twisting, and right ventricular (RV) GLS were measured. RESULTS: The two groups were comparable for body mass index, heart rate, and blood pressure. LV mass index and relative wall thickness were higher in MPS. Ejection fraction (EF), and s' velocity did not differ between the two groups. E/A ratio was lower and E/e' higher in MPS. Tricuspid annular plane systolic excursion, RV s' and e' were lower in MPS. LV GLS did not differ between the two groups, but GCS (P=.014), GRS (P=.023), twisting (P=.012), and RV GLS (P<.001) were lower in the MPS group. CONCLUSIONS: @entity1002 are detectable in MPS pediatric patients, independently of MPS type, when EF is still normal. RV GLS is also involved consensually with TAPSE reduction. STE can be useful for detection of subclinical @entity296 in MPS.

title: XXXX in pediatric patients with mucopolysaccharidoses: A two-dimensional speckle tracking echocardiography study.

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited lysosomal storage disorders']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV global longitudinal strain', 'LV strain abnormalities']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac involvement']

answer: @entity296 :: (MESH:D009202,Disease) :: ['Myocardial deformation']


abstract: We report a reliable @entity712 model in @entity742 using sequential ligation of the homonymous artery and its diagonal branch. After a left anterior thoracotomy in Corridale @entity742 , the homonymous artery was ligated at a point approximately 40% of the distance from the apex to the base of the heart, and after 1 hour, the diagonal vessel was ligated at a point at the same level. Hemodynamic measurements were done preligation, 30 minutes after the homonymous artery ligation, and 1 hour after diagonal branch ligation. The electrocardiograms were obtained as needed, and cardiac function was also evaluated with ultrasonography. After a predetermined interval (2 months for five animals and 3 months for two animals), the animals were reevaluated in the same way as before, and were killed for postmortem examination of their hearts. All seven animals survived the experimental procedures. Statistically significant @entity551 and increases in pulmonary artery capillary wedge pressure were observed 1 hour after sequential ligation of the homonymous artery and its diagonal branch. Untrasonographic analyses demonstrated variable degrees of anteroseptal @entity910 and @entity910 in all animals. The data from animals at 2 months after coronary artery ligation showed significant increases in central venous pressure, pulmonary artery pressure, and pulmonary artery capillary wedge pressure. Left ventricular enddiastolic dimension and left ventricular end-systolic dimension on ultrasonographic studies were also increased. Electrocardiography showed severe ST elevation immediately after the ligation and pathologic Q waves were found at 2 months after ligation. The thin walled infarcted areas with chamber enlargement were clearly seen in the hearts removed at 2 and 3 months after ligation. In conclusion, we could achieve a reliable ovine model of @entity712 using a simple concept of sequential ligation of the homonymous and diagonal arteries. This animal model was comparable to the clinical situation.

title: XXXX model with sequential ligation of the homonymous artery and its diagonal branch in the @entity742 .

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['decreases in systemic arterial blood pressure and cardiac output']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['chronic heart failure']

entities_list: @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesia', 'akinesia']

answer: @entity712 :: (MESH:D006333,Disease) :: ['Chronic heart failure']


abstract: BACKGROUND: Recurrent @entity2419 @entity292 is a challenge for maxillofacial surgeons. In severe cases, microvascular tissue transfer is necessary to treat these @entity1 successfully. METHODS: A 23-year-old @entity1 with @entity3384 , previously treated elsewhere, presented with a 2-cm defect in the @entity2419 . A tongue flap had already been performed. It was decided to close the persistent @entity292 with a lateral upper-arm flap. In a first-step operation, a free graft of buccal @entity5932 was fixed to the lateral upper arm subcutaneously and covered with an alloplastic sheet. After 11 weeks, the prelaminated flap was harvested and transferred to the palate. RESULTS: Integration of the buccal @entity5932 to the upper arm was uneventful. On harvesting the flap, we found a smooth, thin, and @entity400 with a @entity5932 surface of 4 x 4 cm. Healing of the microvascular flap in its recipient site was regular. The @entity292 was closed successfully. CONCLUSIONS: To the authors' knowledge, this is the first report of a lateral upper-arm flap prelaminated with autologous @entity5932 . By prelamination, it is possible to circumvent the disadvantage of extraoral skin within the oral cavity and to cover @entity33 with @entity5932 , especially in elective procedures, such as cleft cases.

title: XXXX @entity292 closure with a mucosal prelaminated lateral upper arm flap.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'man']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucosal defects']

entities_list: @entity400 :: ('MESH:D014202', 'Disease') :: ['continuous fasciomucosal flap']

entities_list: @entity2419 :: ('MESH:D002972', 'Disease') :: ['posterior hard palate', 'cleft palate']

entities_list: @entity3384 :: ('MESH:D002971', 'Disease') :: ['cleft lip and palate']

answer: @entity2419 :: (MESH:D002972,Disease) :: ['Cleft palate']


abstract: BACKGROUND: Increased permeability and uptake of proinflammatory bacterial endotoxins from gut microbiota has been suggested as a mechanism for @entity28 that causes @entity28 -associated insulin resistance. We hypothesized that intestinal barrier function may be restored after Roux-en-Y gastric bypass (RYGB) surgery and thereby contribute to decreased @entity32 . The objective of this study was to investigate levels of the permeability-regulating tight-junction proteins in @entity1 small intestinal mucosa before and after RYGB surgery. METHODS: Paired intraindividual jejunal mucosa samples were retrieved at the time of surgery and 6 to 8 months after surgery. Mucosal cell surface area was calculated by histomorphometry. Mucosal samples were analyzed by proteomics to find patterns of protein regulations. Based on these findings further analyses were performed by Western blotting. Ussing chambers were used to analyze permeability in the retrieved mucosal samples. RESULTS: Mucosal surface area was significantly decreased after surgery. Global protein expression analysis showed a significant increase in the @entity10585 ( @entity10585 ), which was confirmed by Western blotting. Further analyses showed a significant increase in @entity21487 expression after surgery, whereas @entity11177 and zonula occludens-1 levels were decreased. Expressions of @entity3670 and vinculin were unchanged. Ussing chamber experiments revealed a linear correlation between the epithelial electrical resistance and @entity14187 protein expression. CONCLUSION: Several alterations were found in the rerouted small intestine after surgery, indicating a decreased jejunal mucosal surface area and decreased paracellular permeability. These changes could contribute to decreased uptake of luminal microbiota-derived inflammatory mediators such as endotoxins after RYGB.

title: Expression of tight-junction proteins in XXXX proximal small intestinal mucosa before and after Roux-en-Y gastric bypass surgery.

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity-associated chronic inflammation', 'obesity']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The scarcity of sizeable specimens of normal oral mucosa for experimental purposes has hampered research on oral epithelium. Because large specimens of viable @entity1 vaginal mucosa are readily available and because @entity365 are microscopically similar, vaginal mucosa has been used successfully to establish a @entity1 cyst model in experimental animals. The ultrastructure and distribution of keratin filaments in these epithelia are also similar, as is their permeability to water and a number of chemical substances. Therefore, if vaginal mucosa could be substituted for @entity14705 it would expedite research on the epithelium of @entity14705 . To strengthen further the concept that vaginal epithelium could replace buccal epithelium in certain experimental studies, the thickness of these epithelia, their patterns of surface keratinization, the presence or absence of intercellular lipid lamellae and their lipid contents were now compared. Thirty-three specimens of vaginal mucosa from postmenopausal @entity1 and 36 of @entity14705 were investigated. To compare the thickness of the epithelial layers the number of cell layers in sections of 20 vaginal and 20 buccal mucosal specimens were counted in the three thickest and three thinnest regions of each specimen. Surface keratinization was evaluated on sections stained with the Picro-Mallory method. To demonstrate lipid lamellae two vaginal and two @entity14705 specimens were examined electron microscopically after normal fixation and postfixation in @entity69384 . Following solvent extraction of 11 vaginal and 14 @entity14705 , quantitative lipid analyses were performed using thin-layer chromatography. No statistically significant differences were found between the maximum and minimum number of epithelial cell layers. The patterns of surface keratinization and the distribution and appearance of the lipid lamellae in the intercellular spaces were similar. The lipid composition of the two epithelia corresponded, except for the @entity8557 and @entity29434 , which were higher in buccal epithelium. @entity9932 for vaginal epithelium and @entity1674 for buccal epithelium were not determined. Based on structural similarities, a similar lipid composition and earlier findings, it is concluded that vaginal epithelium can be used as a substitute for buccal epithelium in certain in vitro, and possibly for in vivo, studies.

title: A comparative light-microscopic, electron-microscopic and chemical study of XXXX vaginal and buccal epithelium.

entities_list: @entity365 :: ('MESH:D014627', 'Disease') :: ['vaginal and buccal epithelia']

entities_list: @entity14705 :: ('MESH:D007967', 'Disease') :: ['buccal mucosa', 'buccal epithelia']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity69384 :: ('MESH:C027646', 'Chemical') :: ['ruthenium tetroxide']

entities_list: @entity8557 :: ('MESH:D002788', 'Chemical') :: ['cholesterol esters']

entities_list: @entity9932 :: ('MESH:D002518', 'Chemical') :: ['Ceramides']

entities_list: @entity29434 :: ('CHEBI:62941', 'Chemical') :: ['glycosylceramides']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: All cases of neonatal @entity2259 occurring at Neonatal Department of Pediatric Clinic, Catholic University of Rome, from January 1976 to December 1983 were examined retrospectively. Twenty-seven (30%) newborn @entity1 with positive blood cultures for coagulase-negative staphylococcus were identified. Seven (25.9%) of the 27 @entity1 were born at term, 4 AGA and 3 SGA; mean birth weight was 2,804 gm (range 2,280-3,670). All of these neonates had clinical evidence and laboratory signs of @entity295 , and one had the cerebrospinal-fluid culture positive for coagulase-negative staphylococcus. In the remaining 20 @entity1 (74.1%) the mean birth weight was 1,445 gm (range 810 - 2,400) and mean gestational age was 32 weeks (range 27 - 36). In 15 of the 20 preterm @entity1 clinical signs of @entity295 were associated with positive blood culture, and sixty percent of these had received an umbilical artery catheter. An half of coagulase-negative staphylococci isolated from our neonatal @entity295 were DNAse-positive and/or phosphatase-positive and/or @entity2656 -positive. Two full-term @entity1 , one with Down syndrome and one with @entity299 , died at 9 days and at 2 weeks of age, respectively. Three of 15 preterm @entity1 with coagulas-negative @entity295 died; deaths were among @entity1 of very low birth weights and immature gestations who had severe @entity1576 . These data show that coagulase-negative staphylococcus can be important cause of @entity295 in @entity1 with compromised host defenses as newborn @entity1 , and especially in the premature babies receiving invasive procedures.

title: [ XXXX caused by coagulase-negative staphylococci].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'infants']

entities_list: @entity2656 :: ('MESH:D008353', 'Chemical') :: ['mannitol']

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['sepsis', 'staphylococcal septicemia', 'septicemia']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory syndrome']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac malformation']

entities_list: @entity2259 :: ('MESH:D016470', 'Disease') :: ['bacteremia']

answer: @entity295 :: (MESH:D018805,Disease) :: ['Neonatal sepsis']


abstract: INTRODUCTION: @entity1 with @entity309 ( @entity309 ) have an increased cardiovascular (CV) morbidity and mortality. Pulse-wave velocity ( @entity122 ) and augmentation index (AIx) are non-invasive methods to assess arterial @entity2693 , a marker of CV risk. We performed a meta-analysis evaluating the impact of @entity309 on aortic- @entity122 , brachial- @entity122 , brachial-ankle (ba-) @entity122 , AIx, and AIx normalized to a 75 beats/minute heart rate (AIx@75). MATERIALS AND METHODS: Studies evaluating the relationship between @entity309 and aortic- @entity122 , brachial- @entity122 , ba- @entity122 , AIx, and AIx@75 were systematically searched. A total of 25 studies (1,472 @entity309 @entity1 , 1,583 controls) were included. RESULTS: Compared to controls, @entity309 @entity1 showed a significantly higher aortic- @entity122 (mean difference 1.32 m/s; 95% CI 0.77, 1.88; P < 0.00001), ba- @entity122 ( @entity601 198.42 cm/s; 95% CI 45.79, 342.76; P = 0.01), AIx ( @entity601 11.50%; 95% CI 5.15, 17.86; P = 0.0004), and AIx@75 ( @entity601 6.99%; 95% CI 4.92, 9.06; P < 0.00001), with a trend toward a higher brachial- @entity122 ( @entity601 0.34 m/s; 95% CI -0.03, 0.70; P = 0.07). When analyzing studies on early @entity309 , the difference in aortic- @entity122 among @entity309 @entity1 and controls was even higher ( @entity601 2.30 m/s; 95% CI 1.15, 3.45; P < 0.0001). CONCLUSION: Meta-regression showed that a more severe inflammatory status impacted on aortic- @entity122 , AIx, and AIx@75. Arterial @entity2693 , a recognized marker of CV risk, is increased in @entity309 @entity1 . This alteration is associated with the severity of the inflammatory status and is present even in early-stage disease.

title: Non-invasive assessment of arterial @entity2693 in @entity1 with XXXX : A systematic review and meta-analysis of literature studies.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

entities_list: @entity2693 :: ('MESH:C566112', 'Disease') :: ['stiffness']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']