abstract: Increased ECM in @entity235 PVs. INTRODUCTION: Cell uncoupling due to @entity82 or increased extracellular collagen matrix (ECM) affects the formation of ectopic focal activity. Whether or not the increase of ECM also exists in the pulmonary veins (PVs) with rapid atrial pacing is unknown. We sought to test the hypothesis that in chronic atrial pacing @entity235 with sustained @entity955 ( @entity955 ), the amount of ECM was increased in both atria and the PVs. METHODS AND RESULTS: We induced sustained @entity955 in @entity235 by rapid atrial pacing. Computerized mapping techniques were used to map both atria and the PVs. We also used histological assessment to quantify the amount of ECM. After 118+/-24 days of rapid atrial pacing, sustained @entity955 was induced in 7 @entity235 . Repetitive rapid activities (RRAs) either continuously or intermittently arose from the PVs during sustained @entity955 . Histological study shows that there was no @entity82 in both atrial free walls and the PVs. However, the amount of ECM was increased in these regions. The mean ECM surface area fraction at each region in the @entity235 with sustained @entity955 was all significantly higher compared to the corresponding region in normal @entity235 . Similarly, the heterogeneity of the ECM surface area fraction at each region in the @entity235 with sustained @entity955 was also all significantly higher compared to normal @entity235 . CONCLUSIONS: In chronic atrial pacing-induced sustained @entity955 , structural remodeling (i.e., inhomogeneous increase of ECM) also involves the PVs. Reduced coupling of the myocytes in the PV due to histological changes may provide an additional mechanism facilitating RRAs.

title: Increased extracellular collagen matrix in myocardial sleeves of pulmonary veins: an additional mechanism facilitating repetitive rapid activities in chronic pacing-induced sustained XXXX .

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

answer: @entity955 :: (MESH:D001281,Disease) :: ['atrial fibrillation']


abstract: OBJECTIVES: We sought to compare the maternal and fetal outcomes of @entity1 with severe @entity4794 submitted to percutaneous @entity384 versus open mitral valve commissurotomy (MVC) during pregnancy. BACKGROUND: @entity712 in @entity1 with @entity4794 complicating pregnancy is a common problem in developing countries. Since 1984, percutaneous dilation of the mitral valve using a balloon catheter has become a therapeutic alternative to open heart surgery. Although the efficacy of percutaneous mitral @entity384 is well established, its results have never before been compared with the results of commissurotomy during pregnancy. METHODS: We compared the clinical and obstetric complications in 45 @entity1 who were treated with percutaneous mitral @entity384 (group I, n = 21; from 1990 to 1995) or open MVC (group II, n = 24; from 1985 to 1990) for severe @entity712 due to @entity4794 during pregnancy. RESULTS: In our study, percutaneous @entity384 of the mitral valve had a success rate of 95% (Gorlin formula) and 90.5% (echocardiographic "pressure half-time" method), as demonstrated by the final mitral valve area achieved. This improvement was followed by a marked decrease in the mitral valve gradient, left atrial pressure and mean pulmonary artery pressure. @entity1 in both groups had similar improvements in symptoms. @entity1 who underwent percutaneous @entity384 had significantly fewer @entity2241 , with a reduction in fetal and neonatal mortality (1 death in group I vs. 8 in group II, p = 0.025). CONCLUSIONS: @entity661 is safe and effective and appears to be preferable for the fetus, compared with open MVC during pregnancy.

title: @entity661 in comparison with open mitral valve commissurotomy for XXXX during pregnancy.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['Heart failure', 'heart failure']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['balloon dilation', 'valve balloon dilation']

entities_list: @entity661 :: ('MESH:D054549', 'Disease') :: ['Percutaneous balloon mitral valvuloplasty']

entities_list: @entity4794 :: ('MESH:D008946', 'Disease') :: ['mitral stenosis']

entities_list: @entity2241 :: ('MESH:D005315', 'Disease') :: ['fetal complications']

answer: @entity4794 :: (MESH:D008946,Disease) :: ['mitral stenosis']


abstract: The present studies were conducted in conscious, instrumented @entity35 to evaluate measurements of aortic peak flow velocity ( @entity18179 ) as an index of myocardial contractility. Because our previous studies had characterized/verified procedures to determine pressure-derived indices of contractile function in the anesthetized, ventilated, open-chest @entity35 , we first correlated @entity18179 with (a) maximum rate of left ventricular pressure development (max +dP/dt) and (b) a contractility index derived by dividing max +dP/dt by left ventricular pressure at max +dP/dt [(dP/dt)/P] in anesthetized @entity35 (n = 5). The positive inotropic agent, @entity3044 , given by bolus intravenous injection (0.2 microgram), significantly and concurrently increased dP/dt, (dP/dt)/P, and @entity18179 . The negative inotropic agent, @entity1169 , given by bolus intravenous injection (2 mg/kg), significantly and concurrently attenuated all of the above measurements. When control, @entity3044 , and @entity1169 responses were used to calculate multivariate correlation coefficients among dP/dt, (dP/dt)/P, and @entity18179 , r values ranged from 0.74 ( @entity18179 vs. dP/dt) to 0.84 (dP/dt vs. (dP/dt)/P) to 0.91 ( @entity18179 vs. (dP/dt)/P). A separate group of @entity35 (n = 4) was surgically implanted with ascending aortic blood flow sensors, carotid artery and jugular vein catheters. Intravenous @entity3044 (0.2 microgram, bolus) elicited increased cardiac (heart rate and cardiac output) and decreased peripheral vascular resistance (mean arterial blood pressure) beta-adrenergic receptor agonist effects. @entity1169 (2 mg/kg, i.v. bolus) produced hemodynamic effects consistent with cardiovascular beta-adrenergic receptor blockade. @entity3044 and @entity1169 had directionally appropriate, and significant effects on @entity18179 in the conscious @entity35 . When compared with @entity18179 values under control conditions in the anesthetized @entity35 , conscious @entity35 values are approximately double those observed under anesthesia; however, the relative @entity18179 responses to @entity3044 and @entity1169 were not affected. Therefore, the present studies provide evidence that aortic @entity18179 can be utilized as an estimate of heart contractile performance, i.e., myocardial contractility, in the conscious, instrumented @entity35 .

title: Aortic peak flow velocity as an index of myocardial contractility in the conscious XXXX .

entities_list: @entity3044 :: ('MESH:D007545', 'Chemical') :: ['Isoproterenol', 'isoproterenol']

entities_list: @entity1169 :: ('MESH:D011433', 'Chemical') :: ['propranolol', 'Propranolol']

answer: @entity35 :: (10116,Species) :: ['rat']


abstract: Insulin-like growth factors (IGFs) play an important role in regulating vascular smooth muscle cell (VSMC) proliferation and directed migration. IGFs exert these biological actions through the activation of the @entity2856 and its downstream signaling network. While the involvement of the IRS-PI3 kinase- @entity584 pathway in mediating the chemotactic and mitogenic actions of IGFs is clear, the role of the mitogen-activated protein kinase (MAPK) signaling pathway is still under debate. In this study, the role of @entity1366 in mediating the chemotactic and mitogenic actions of @entity442 in cultured porcine VSMCs was investigated. @entity442 treatment caused a significant increase in the phosphorylation state, as well as the kinase activity, of @entity1366 . Compared to the strong and sustained MAPK activation induced by platelet-derived growth factor-BB, the @entity442 -induced MAPK activation was weaker and more transient. Specific inhibition of the MAPK activation by @entity4286 or @entity5732 , two selective MEK inhibitors, significantly inhibited @entity442 -stimulated cell proliferation, and reduced the number of cells that migrated towards @entity442 . The p38 MAPK inhibitor @entity1441 had no such effect. Likewise, depletion of @entity1366 using antisense oligonucleotides abolished the @entity442 -induced VSMC migration and proliferation. These results suggest that the chemotactic and mitogenic responses of VSMCs to @entity442 require the activation of @entity1366 .

title: The chemotactic and mitogenic responses of vascular smooth muscle cells to insulin-like growth factor-I require the activation of XXXX .

answer: @entity1366 :: (5595;5594,Gene) :: ['ERK1/2']


abstract: UNASSIGNED: Isolated @entity453 ( @entity453 ) may be associated with stable or unstable coronary events despite the absence of @entity3979 . Impaired coronary flow dynamics and myocardial perfusion have been demonstrated in stable @entity1 with ectatic coronary arteries. We aimed to assess whether epicardial flow and tissue-level perfusion would be improved by @entity3988 in myocardial regions subtended by the ectatic coronary arteries in @entity1 with @entity453 . A total of 60 @entity1 with @entity453 were identified of 9,780 @entity1 who underwent elective coronary angiography. @entity1 were randomized to 5  mg of intracoronary @entity3988 or saline. Coronary blood flow of the microvascular network was assessed using myocardial blush grade ( @entity7584 ) technique. The thrombolysis in @entity583 (TIMI) flow grade and TIMI frame count (TFC) were used to assess epicardial coronary flow. @entity7584 (from 2.4 to 2.6, p  = 0.02), TIMI flow grades (from 2.4 to 2.8, p <0.001), and TFC (from 35 to 26, p <0.001) were significantly improved after @entity3988 , whereas no significant change was noticed after saline (from 2.4 to 2.4, p  = 0.86 for @entity7584 ; from 2.3 to 2.3, p  = 0.71 for TIMI flow grade; and from 35 to 33, p  = 0.43 for TFC). @entity3988 provided amelioration of the altered coronary flow dynamics, which was suggested as the pathophysiological influence of @entity453 . In conclusion, the favorable effects of the @entity3988 on myocardial perfusion were observed at both epicardial and tissue levels.

title: Effect of XXXX on Coronary Artery Flow and Myocardial Perfusion in @entity1 With Isolated Coronary Artery Ectasia and Either Stable Angina Pectoris or Positive Myocardial Ischemic Stress Test.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

entities_list: @entity3988 :: ('MESH:D004110', 'Chemical') :: ['diltiazem', 'Diltiazem']

entities_list: @entity3979 :: ('MESH:D023921', 'Disease') :: ['epicardial coronary stenosis']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery ectasia', 'CAE', 'isolated CAE']

answer: @entity3988 :: (MESH:D004110,Chemical) :: ['Diltiazem']


abstract: A signaling cascade that includes @entity7131 ( @entity7131 ), Ras, and @entity44985 regulates @entity40330 ( @entity41579 ) gene expression in epidermal keratinocytes (Efimova, T., LaCelle, P., Welter, J. F., and Eckert, R. L. (1998) J. Biol. Chem. 273, 24387-24395 and Efimova, T., and Eckert, R. L. (2000) J. Biol. Chem. 275, 1601-1607). Because signal transfer downstream of @entity44985 may involve several MAPK kinases (MEKs), it is important to evaluate the regulatory role of each MEK isoform. In the present study we evaluate the role of @entity32027 in transmitting this signal. Constitutively active @entity32027 (caMEK6) increases @entity41579 promoter activity and increases endogenous @entity41579 levels. The caMEK6-dependent increase in gene expression is inhibited by the p38 MAPK inhibitor, @entity1441 , and is associated with a marked increase in @entity1435 MAPK activity; JNK and ERK kinases are not activated. In addition, @entity41579 gene expression is inhibited by dominant-negative @entity1435 and increased when caMEK6 and @entity1435 are co-expressed. caMEK6 also activates @entity10887 , but @entity10887 inhibits the caMEK6-dependent activation. These results suggest that @entity32027 increases @entity41579 gene expression by regulating the balance between activation of @entity1435 , which increases gene expression, and @entity10887 , which decreases gene expression.

title: @entity32027 regulates human @entity40330 gene expression via a @entity1435 - and XXXX -dependent mechanism.

entities_list: @entity7131 :: ('MESH:D020151', 'Disease') :: ['protein kinase C', 'PKC']

answer: @entity10887 :: (5603,Gene) :: ['p38delta']


abstract: BACKGROUND AIMS: Bone marrow (BM) transplantations are an accepted therapeutic strategy for hematologic conditions. In the past decades, interest for BM-derived cell therapy has extended toward the field of regenerative medicine. Irrespective of the treatment strategy, its success depends on the amount of cells available for transplantation. Both @entity1 and procedural factors have been shown to influence the cell density of the BM aspirate. In the present study, the influence of core diameter of the BM aspiration device on cell density of the BM aspirate is studied. METHODS: BM harvesting procedures performed in a clinical trial investigating the effect of BM cell therapy in @entity1 with severe @entity3657 were retrospectively studied (clinicaltrials.govNCT00371371). @entity1 underwent BM harvesting through the use of either a 15-gauge (n  = 85) or an 8-gauge (n  = 75) needle. The numbers of harvested white blood cells (WBC) and @entity2280 (+) @entity1583 ( @entity1583 ) were quantified. RESULTS: The amount of WBC per milliliter of BM aspirate was significantly higher when the 8-gauge needle (27.8  * 10(6) WBC/mL [95%CI 25.4-30.5  * 10(6)]) was used compared with the smaller 15-gauge core needle (20.1  * 10(6) WBC/mL [95% confidence interval (CI), 18.7-21.7  * 10(6)], P  < 0.001). For the amount of @entity2280 (+) @entity1583 , a similar pattern was observed (185  * 10(3) @entity1583 /mL [95% CI, 161-213  * 10(3)]; 114  * 10(3) @entity1583 /mL [95% CI, 96-134  * 10(3)]; P  < 0.001). CONCLUSIONS: The application of a BM aspiration device with a larger core diameter is associated with an increased cell density of the BM aspiration product in @entity1 with severe @entity3657 .

title: Core diameter of bone marrow aspiration devices influences cell density of bone marrow aspirate in XXXX with severe @entity3657 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['HPC', 'hematopoietic cells']

entities_list: @entity3657 :: ('MESH:D058729', 'Disease') :: ['peripheral artery disease']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: Cymbopogon citratus (Poaceae) a tropical perennial herb plant that is widely cultivated to be eaten either fresh with food or dried in tea or soft drink has been reported to possess a number of medicinal and aromatic properties. This study aimed at evaluating the protective effects of C. citratus aqueous extract against @entity99 induced by @entity273 ( @entity274 ), in male @entity35 . MATERIALS AND METHODS: Twenty-five @entity35 were randomly divided into five different groups of five animals in each group; (1) Control. (2) Received @entity274 (0.5%) with drinking water. (3), and (4) received @entity274 and C. citratus (100 mg  kg(-1) b wt), @entity620 (250 mg  kg(-1) b wt) respectively. (5), was given C. citratus alone. The treatments were administered for 30 days. Blood samples were collected and serum was used for biochemical assay including liver enzymes activities, total protein, total @entity648 and @entity1234 , @entity2041 in serum and liver homogenates. Liver was excised and routinely processed for histological examinations. RESULTS: C. citratus attenuated @entity409 due to @entity274 administration as indicated by the significant reduction (p<0.05), in the elevated levels of ALT, AST, @entity6032 , LDH, @entity1906 , and @entity1865 in serum and liver homogenates; increase in TP and @entity2197 levels in serum and liver homogenates; and improvement of liver histo-pathological changes. These effects of the extract were similar to that of @entity620 which used as antioxidant reference. CONCLUSION: C. citratus could effectively ameliorate @entity274 -induced oxidative stress and prevent @entity99 in male @entity35 .

title: Hepatoprotective effect of cymbopogon citratus aqueous extract against @entity273 -induced @entity99 in male XXXX .

entities_list: @entity620 :: ('MESH:D001205', 'Chemical') :: ['vitamin C']

entities_list: @entity648 :: ('MESH:D001663', 'Chemical') :: ['bilirubin']

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['liver damage']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity273 :: ('MESH:D006861', 'Chemical') :: ['hydrogen peroxide']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['malonaldehyde']

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['liver injury']

answer: @entity35 :: (10116,Species) :: ['rats']


abstract: OBJECTIVE: To compare the effects of @entity11796 and micronized @entity1420 on the lipid profile of postmenopausal @entity1 receiving conjugated @entity1641 @entity172 . STUDY DESIGN: A prospective, clinical study of the changes in lipoprotein profile evaluated in 123 postmenopausal @entity1 receiving conjugated @entity172 alone (group I), conjugated @entity172 combined with @entity11796 (group II) or micronized @entity1420 (group III) before treatment and six months after. RESULTS: Group I had significantly increased high-density lipoprotein @entity165 (HDL-C) levels (14.4%) after six months as well as decreased low-density lipoprotein @entity165 (LDL-C) concentrations (-6.61%), LDL/HDL and total @entity165 /HDL-C ratios (P < .05). In groups II and III, HDL-C concentrations increased 4.58% and 5.44%, respectively, after six months. LDL-C levels were markedly decreased in group II (8.98%). There was no significant reduction in LDL-C levels in group III. Total @entity165 levels were significantly decreased only in group II (-4.93%). @entity412 levels were increased with statistical significance only in group III (21.2%, P < .05). LDL/HDL and total @entity165 / HDL-C ratios were significantly decreased in group II, and this effect was more pronounced in group I. There was no change in the ratios in group III. CONCLUSION: Conjugated @entity172 replacement therapy had a persistent cardioprotective effect in postmenopausal @entity1 , based on the positive effect on lipoprotein metabolism. Both natural and synthetic progesterones blunt the beneficial effects of @entity172 on the lipoprotein profile, and micronized @entity1420 is not superior to @entity11796 .

title: Changes in the lipoprotein profile in postmenopausal XXXX receiving hormone replacement therapy. Effects of natural and synthetic @entity1420 .

entities_list: @entity172 :: ('MESH:D004967', 'Chemical') :: ['estrogen']

entities_list: @entity11796 :: ('MESH:D017258', 'Chemical') :: ['medroxyprogesterone acetate']

entities_list: @entity1420 :: ('MESH:D011374', 'Chemical') :: ['progesterone']

entities_list: @entity412 :: ('CHEBI:17855', 'Chemical') :: ['Triglyceride']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity1 :: (9606,Species) :: ['women']


abstract: Clinical characteristics of 97 @entity1 with @entity302 associated with a small single cerebral @entity730 (SSCCCTL), measuring 20 mm or less were analysed. The mean age was 20 years and 60% were in the first and second decades. Eighteen (18.5%) @entity1 had a previous history of unprovoked @entity410 , with complex partial @entity410 (61%) being the most common type. @entity410 could be localized to a single ILAE site in 73% of @entity1 . None had @entity51 and electroencephalograph abnormalities were noted in 29% of @entity1 . Fifty-one (53%) @entity1 had @entity410 and were more common with frontal location. By 7 years 71.5% (95% confidence intervals (CI) 53.7-85.4) of @entity1 achieved 3-year remission and 66% (CI 32.4-88.2) had achieved 5-year remission. The clinical pattern of the @entity410 was clearly distinctive to allow it to be localized to the location of the lesion on computerized tomography (CT) scan in 25 (26%) @entity1 and in another 31 (31%) @entity1 nearer to the anatomical site of the lesion on the CT scan. There was discordance between clinical localization and CT location of the lesion in 15 @entity1 . Nine of the 10 @entity1 with occipital or parieto-occipital location had focal @entity410 with secondary generalization. Both @entity1 with temporal location had motor @entity410 . The relevance of these findings to the @entity410 propagation was discussed.

title: Clinical characteristics, @entity410 spread patterns and prognosis of XXXX associated with a single small cerebral @entity730 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'Seizures', 'breakthrough seizures', 'seizures', 'tonic-clonic seizures']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcific CT lesion']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['neurological deficit']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

answer: @entity410 :: (MESH:D012640,Disease) :: ['seizures']


abstract: BACKGROUND/PURPOSE: Unfavorable histology (UH) in @entity3969 has been linked to malfunction of the @entity899 @entity5 suppressor gene, which regulates (1) the endogenous angiogenesis suppressor @entity39244 ( @entity39244 ) and (2) @entity1611 ( @entity1611 ). The authors hypothesized that clinically aggressive favorable histology @entity3969 ( @entity753 ), like UH, but distinct from standard-risk @entity753 disease, would display altered @entity899 / @entity39244 function and upregulated angiogenesis. METHODS: Three @entity3969 specimens manifesting different histology and clinical behavior were obtained: clinically aggressive UH, clinically aggressive @entity753 , and standard-risk @entity753 disease. Xenografts were induced intrarenally in athymic @entity19 . @entity899 , @entity39244 , and @entity1611 status and @entity2295 were assessed in @entity5 tissues. Lungs were evaluated for @entity3 . RESULTS: Clinically aggressive @entity753 @entity3969 displayed progressive alteration in @entity899 / @entity39244 status and upregulation of @entity1611 . Such alteration was observed in the UH @entity5 , but was absent from the standard-risk @entity5 . Xenografts from clinically aggressive @entity5 displayed brisk neoangiogenesis and yielded lung metastases. CONCLUSIONS: This is the first report of altered @entity899 / @entity39244 function in association with clinically aggressive behavior in @entity753 @entity3969 . These characteristics were not observed in parallel studies of a nonaggressive @entity5 . Loss of wild-type @entity899 function may contribute to disease progression in @entity753 @entity3969 , in part by upregulation of @entity1611 .

title: XXXX accumulation in favorable-histology @entity3969 is associated with angiogenesis and clinically aggressive disease.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'FH tumor', 'tumors']

entities_list: @entity2295 :: ('MESH:D015861', 'Disease') :: ['neovascularity']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity3969 :: ('MESH:D009396', 'Disease') :: ['Wilms tumor']

entities_list: @entity1611 :: ('22339(Tax:10090)', 'Gene') :: ['vascular endothelial growth factor', 'VEGF']

answer: @entity899 :: (22060(Tax:10090),Gene) :: ['p53']


abstract: OBJECTIVE: To describe attitudes toward the @entity10281 ( @entity10281 ) among Department of Veterans Affairs (VA) nursing home care unit (NHCU) clinical leadership. DESIGN: Cross-sectional online survey using structured (quantitative) and open-ended (qualitative) items. SETTING: Approximately 97 VA Medical Center NCHUs nationwide. @entity1 : A total of 289 directors of nursing, medical directors, @entity10281 coordinators, nurse managers and other clinical management staff. MEASUREMENTS: Quantitative ratings of the @entity10281 's accuracy, usefulness for initial and ongoing care planning, and utility for quality improvement; content analysis of open-ended items describing perceived causes of inaccuracy and reasons for use/nonuse in care planning and quality improvement. RESULTS: Although quantitative ratings were generally positive, qualitative analysis yielded a number of emergent themes regarding data accuracy, team functioning, timeliness of assessments, and validity of the @entity10281 tool itself. Medical directors were somewhat less positive about the @entity10281 than were other NHCU leadership. Very large and very small facilities were less likely to view the tool as useful and to use it for care planning and quality improvement. CONCLUSIONS: NHCU clinical leadership clearly has a "love-hate" relationship with the @entity10281 . They value information it provides, but identify a number of weaknesses that limit its utility for clinical use.

title: "Sometimes XXXX don't fit in boxes": attitudes toward the minimum data set among clinical leadership in VA nursing homes.

entities_list: @entity1 :: ('9606', 'Species') :: ['PARTICIPANTS']

entities_list: @entity10281 :: ('MESH:D020920', 'Disease') :: ['Minimum Data Set', 'MDS']

answer: @entity1 :: (9606,Species) :: ['people']


abstract: The present study compares the effects of @entity68175 , a novel @entity972 channel opener, with those of @entity31802 and @entity9805 on blood pressure and other haemodynamic parameters. In conscious, spontaneously @entity101 @entity35 (SHR) the oral dose of @entity68175 for lowering blood pressure was 10 times lower than that of @entity31802 and some 100 times lower than that of @entity9805 . In addition, the duration of antihypertensive activity of @entity68175 was longer than that of @entity31802 or @entity9805 . The @entity591 evoked by @entity68175 and @entity31802 was of shorter duration than the antihypertensive effect of either agent. In a repeat, once daily dosing experiment no tolerance was observed to the antihypertensive effect of @entity68175 over a 22-day period. In conscious normotensive @entity468 @entity68175 was 10 times more potent than @entity31802 and 1,000 times more potent than @entity9805 in reducing blood pressure. The duration of @entity551 activity was in excess of 5 h for each agent. In anaesthetised @entity235 all three agents reduced mean arterial pressure (MAP) and total peripheral resistance (TPR), while increasing cardiac output (CO) via a rise in @entity64 volume (SV). Both @entity68175 and @entity31802 significantly reduced femoral (FVR) and mesenteric vascular resistances (MVR), while only @entity31802 reduced renal vascular resistance (RVR). @entity68175 is a potent new antihypertensive agent that compares favourably with @entity31802 and @entity9805 .

title: Preclinical pharmacology of @entity68175 , a new XXXX channel opener.

entities_list: @entity31802 :: ('MESH:D019806', 'Chemical') :: ['cromakalim']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity9805 :: ('MESH:D009568', 'Chemical') :: ['nitrendipine']

entities_list: @entity591 :: ('MESH:D013610', 'Disease') :: ['tachycardia']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotensive']

answer: @entity972 :: (MESH:D011188,Chemical) :: ['potassium']


abstract: UNASSIGNED: Inherited mild @entity19434 belongs to one of the most underdiagnosed @entity548 disorders so far. This is, because most @entity1 do not develop @entity548 complications in daily life. @entity1 , methods: A @entity1 (age: 64 years) without a history of @entity548 presented with @entity4048 , @entity353 , @entity417 and @entity548 from the right tonsil necessitating tonsillectomy. Histologic and immunohistochemical evaluation revealed @entity5426 . @entity1003 status showed significantly elevated D-dimer and decreased FXIII levels (FXIII-activity 35%, FXIIIA-Ag 16-26%). Plasma mixing studies excluded neutralizing antibodies against FXIII. RESULTS: A novel heterozygous @entity21939 gene nonsense mutation ( @entity69915 , @entity69916 ) was found confirming heterozygous FXIII-A deficiency. The same mutation was detected in two further asymptomatic relatives. For further clinical management the @entity1 was transfused with FXIII-concentrate and showed an adequate increase of FXIII ruling out @entity942 to be induced by increased turnover. Despite this haemostatic management and antifibrinolytic treatment the @entity1 had to undergo several revisions due to delayed, Hb relevant @entity548 after cervical lymph nodes extirpation and resection of tonsil. Two chemotherapy cycles with @entity1311 and palliative radiotherapy of the neck area were performed, but the @entity1 died unfortunately two months after diagnosis. CONCLUSIONS: It is a unique case showing the combination of a highly aggressive @entity5426 and presence of @entity74 . It is also a rare example demonstrating the benefit of FXIII genotyping besides the expected acquired @entity942 possibly due to @entity5 induced increased consumption by elevated crosslinking of fibrin fibers.

title: XXXX -induced @entity548 in inherited, heterozygous FXIII-A  deficiency.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patient', 'man']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['episodic bleeding', 'bleeding']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['neoplasm']

entities_list: @entity5426 :: ('MESH:D006394', 'Disease') :: ['cytokeratin-positive epitheloid angiosarcoma', 'angiosarcoma']

entities_list: @entity1311 :: ('MESH:D017239', 'Chemical') :: ['paclitaxel']

entities_list: @entity1003 :: ('MESH:D001778', 'Disease') :: ['Blood coagulation']

entities_list: @entity4048 :: ('MESH:D019547', 'Disease') :: ['painful swelling of neck']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['inherited FXIII deficiency']

entities_list: @entity69915 :: ('p|SUB|E|103|X', 'ProteinMutation') :: ['p.Glu103Ter']

entities_list: @entity19434 :: ('MESH:D005177', 'Disease') :: ['factor XIII deficiency']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['FXIII deficiency']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Neoplasm']


abstract: The objective was to study the effects of @entity1 -specific vaccine immunotherapy administered with either @entity379 ( @entity379 ) or @entity2841 ( @entity2841 ) in @entity1 with @entity5 . Short-term cell lines were established from @entity5 tissue resected from @entity1 with @entity5 for use as @entity5 cell vaccines. Successful cultures were expanded to 1 to 2 x 108 cells, irradiated, and cryopreserved in aliquots of 106 cells for intradermal testing of delayed @entity5 hypersensitivity and 107 cells for subcutaneous vaccinations. The study design was that of a randomized phase 2 trial. @entity1 were stratified by @entity5 type and by whether they had measurable disease at the time vaccination was to commence, and then randomized to receive either 100 MIU @entity379 subcutaneously or 500 microg @entity2841 subcutaneously at the time of each @entity5 cell vaccination. Following a baseline test of @entity56 ( @entity56 ) to an intradermal injection of 106 irradiated @entity5 cells, @entity1 received 3 weekly subcutaneous injections of 107 cells, had a repeat @entity56 test at week 4, then received monthly vaccinations for 5 months. A positive @entity56 test was defined as at least 10 mm of induration; survival was determined from the first @entity56 test. There were 98 @entity1 enrolled with a median follow-up of over 4 years. The most prevalent diagnoses were @entity320 (51), @entity1358 (18), and soft-tissue @entity242 (14). There were 49 @entity1 (26 @entity1 , 23 @entity1 , average age 50.4 years) randomized to @entity379 and 49 (28 @entity1 , 21 @entity1 , average age 54.1 years) to @entity2841 . The average numbers of vaccine and adjuvant injections were 6.3 and 5.9, respectively. For the @entity1 who received @entity379 , the objective response rate was 0 of 21; for @entity1 who received @entity2841 the response rate was 1 of 26. Only eight @entity1 (four from each arm) had a positive baseline @entity56 reaction to @entity5 . The @entity5 @entity56 test converted from negative to positive in 13 of 45 of the @entity379 group and 11 of 43 of the @entity2841 group. With 29 @entity1 deceased in the @entity379 arm and 31 in the @entity2841 arm, the 2-year and 5-year survival rates were 45% and 29% for the @entity379 arm and 41% and 23% for the @entity2841 arm ( @entity168 ). Both adjuvants were well tolerated and results were similar in both arms of the study. Both adjuvants were associated with a 25% to 30% rate of @entity56 conversion and a 25% 5-year survival rate. Immune recognition of @entity5 can be induced with this approach.

title: @entity379 or granulocyte-macrophage colony-stimulating factor administered as adjuvants with a vaccine of irradiated @entity5 cells from short-term cell line cultures: a randomized phase 2 trial of the XXXX biotherapy research group.

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'women', 'Patients', 'patients', 'patient']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'autologous tumor', 'cancer', 'metastatic cancer']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['renal cell carcinoma']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['DTH', 'delayed-type hypersensitivity']

entities_list: @entity379 :: ('3458', 'Gene') :: ['IFNgamma', 'interferon-gamma']

entities_list: @entity2841 :: ('1437', 'Gene') :: ['granulocyte-macrophage colony stimulating factor', 'GM-CSF']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['cancer']


abstract: UNASSIGNED: Genetic background plays an important role in the development of @entity2074 . A genome-wide association study (GWAS) showed that nine loci are associated with the disease, six of which contain genes that are involved in Wnt signaling ( @entity17731 , @entity18182 , @entity13023 , @entity43125 , @entity18181 , @entity19922 ). To obtain insight in the role of these genes, we performed expression studies on affected and unaffected @entity1 's tissues. Surgically obtained nodules and cords from eight Dupuytren's @entity1 were compared to @entity1 -matched control tissue (unaffected transverse palmar fascia). The Wnt-related genes found in the GWAS, the classical Wnt-downstream protein @entity3546 , as well as (myo)fibroblast markers were analyzed using real-time qPCR and immunohistochemical stainings for mRNA levels and protein levels, respectively. The collagen-coding genes @entity13239 and @entity1414 were highly upregulated on mRNA level, both in cords and nodules. Three Wnt-related genes were found to be differently regulated compared to control tissue: @entity17731 was downregulated in nodules, @entity13023 was upregulated in nodules, and @entity18181 was upregulated in nodules and cords. Immunohistochemistry revealed significantly less staining of @entity17731 in cords, but significantly more staining for @entity13023 in nodules. There was significantly more staining of @entity1970 in nodules and cord and @entity3546 in nodules than in control tissue. We found differences in expression, both at mRNA and protein level, in several Wnt-related genes found earlier to be associated with @entity2074 . Of these, @entity13023 was upregulated and found in close association with both @entity1970 and @entity3546 expressing cells, making it a candidate pro-fibrotic mediator in @entity2074 .

title: Further evidence of the involvement of the Wnt signaling pathway in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2074 :: ('MESH:D004387', 'Disease') :: ["Dupuytren's disease"]

answer: @entity2074 :: (MESH:D004387,Disease) :: ['Dupuytren's disease']


abstract: BACKGROUND: Anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty have been widely used to treat @entity1 with cervical spondylotic @entity602 and/or @entity614 . In our clinical practice, many @entity1 with @entity4720 also complain of @entity10 , and wish to know if the surgical treatment for @entity4720 can also alleviate this symptom. Considering that there is no literature concerning this extra benefit of surgical manipulation on @entity4720 , we have carried out this retrospective study. METHODS: Among the @entity1 treated with anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty in our institute for cervical spondylotic @entity602 and/or @entity614 between February 2002 to March 2011, 108 of whom that have complained about @entity10 at the same time were included in this study. Those @entity1 were followed by 25 to 145  months. Severity of @entity10 before the surgery and at the last follow up was recorded by VAS @entity158 scores and compared among the @entity1 with different surgical methods using SPSS17.0 software. One way ANOVA was used to compare VAS scores between the groups, paired sample t-tests were used to compare the differences in a group at different time points. RESULTS: @entity10 was significantly alleviated in all groups (P   <   0.01). Respectively, 75.0  % of the @entity1 in the ACDF group, 84.6  % of the @entity1 in the TDR group and 82.2  % of the @entity1 in the laminoplasty group were significantly relieved of the @entity10 after the surgery. No significant differences were found with the VAS score at the last follow up among the groups (P   >   0.05). No significant differences were found among the groups comparing the degree of alleviation of VAS scores before and after the surgery (P   >   0.05). DISCUSSION: Considering that all the three procedures in the current study have achieved similar effect on alliviating @entity10 in @entity1 with cevical @entity602 , and that what they have in common was that was the decompression of spinal cord, it can be assumed that the @entity10 associated with @entity4720 may be the result of compression on the spinal cord. CONCLUSIONS: Anterior cervical discectomy and fusion, total disk replacement and open door laminoplasty can all significantly alleviate @entity10 in @entity1 with cervical spondylotic @entity602 and/or @entity614 . No surgical technique is better than any other technique on alleviating cervical @entity10 associated with cervical spondylotic @entity602 and/or @entity614 .

title: Effect of different surgical methods on XXXX associated with cervical spondylotic @entity602 and/or @entity614 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['myelopathy']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache', 'Headache']

entities_list: @entity614 :: ('MESH:D011843', 'Disease') :: ['radiculopathy']

entities_list: @entity4720 :: ('MESH:D055009', 'Disease') :: ['cervical spondylosis']

answer: @entity10 :: (MESH:D006261,Disease) :: ['headache']


abstract: BACKGROUND: Studies on the relationship between @entity251 concentrations and blood pressure have yielded inconsistent results. Therefore, this study investigated the prospective association of total @entity251 (TT) concentrations with risk of incident @entity101 and blood pressure change in 1,484 @entity1 aged 20-79 years. METHODS: Data from the population-based Study of Health in Pomerania, Germany, were used. Serum TT concentrations, measured by chemiluminescent enzyme immunoassays, were categorised into age-specific quartiles. Generalised Estimating Equation (GEE) models, adjusted for age, waist circumference, physical activity, smoking and @entity167 consumption were specified. RESULTS: During a median follow-up time of 5.0 years, the prevalence of @entity101 increased from 50.6% to 57.1%. TT concentrations were significantly lower in @entity1 with baseline and incident @entity101 . Analyses revealed that @entity1 with baseline TT concentrations in the lowest quartile had an increased risk of incident @entity101 (odds ratio (OR), 1.19 (95% CI, 1.10-1.28)) compared to @entity1 with higher TT concentrations. Furthermore, we found a significant inverse association of TT concentrations and blood pressure, showing that @entity1 with baseline TT concentrations in the lowest quartile showed the slightest change in systolic blood pressure (-6.01 mmHg), diastolic blood pressure (-2.11 mmHg) and pulse pressure (-3.98 mmHg). Sensitivity analyses in a subpopulation of men without antihypertensive medication confirmed these findings. CONCLUSION: These results show that low male TT concentrations are predictive of @entity101 , suggesting TT as a potential biomarker of increased cardiovascular risk.

title: Inverse association between total XXXX concentrations, incident @entity101 and blood pressure.

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['alcohol']

answer: @entity251 :: (MESH:D013739,Chemical) :: ['testosterone']


abstract: A retrospective review was conducted of 122 charts of @entity1 with clinically diagnosed @entity195 (CDAD) who had participated in a @entity303 study at the Mayo Clinic from 1965 to 1970. DSM-III-R diagnoses were assigned based on the longitudinal description of symptoms detailed in the Mayo Clinic medical records of the hospitalizations; clinic, home, and nursing home visits; and state hospital admissions. Thirty @entity1 (25%) were found to have a @entity933 episode during their course of CDAD that occurred during inpatient admissions; 50% (15 of 30) of the @entity933 episode occurred in @entity1 ages 80 to 89. Among @entity1 with a @entity933 episode, 50% died within one year of the @entity933 episode and 64% died within two years. Of 13 @entity1 , 10 (77%) had multiple @entity933 episodes within two years. Admitting diagnoses were mainly primary degenerative @entity303 of the @entity195 with @entity933 . Only 3 (10%) demented @entity1 experienced @entity933 episodes during a medical admission. No @entity204 occurred during hospitalization for the years covered by this study. A psychiatric consultation was requested in only 17 (14%) @entity1 ; 88% of these @entity1 received diagnoses involving PDDAT, late onset. An additional diagnosis included @entity308 . Psychopharmacology was the major management strategy (82% of @entity1 with a @entity933 episode received medication) with a resolution of symptoms within 48 hours. At discharge, only 2 (7%) @entity1 failed to clear the increased degree of @entity911 .

title: XXXX episodes during the course of clinically diagnosed @entity195 .

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['longitudinal dementia', 'dementia']

entities_list: @entity911 :: ('MESH:D003221', 'Disease') :: ['confusion']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ["Alzheimer's disease", "Alzheimer's type (PDDAT) or PDDAT"]

entities_list: @entity933 :: ('MESH:D003693', 'Disease') :: ['delirium']

answer: @entity933 :: (MESH:D003693,Disease) :: ['Delirium']


abstract: Sixty @entity1 with chronic @entity615 or lumboischialgia with exacerbation for at least 1 month were included in the study. A main group consisted of 40 @entity1 and a control group of 20 @entity1 . All @entity1 took @entity3522 in dosage 100 mg per day from the 1st day. Versatis was prescribed to @entity1 of the main group from the 6th day. One-three plates were applied to the most painful spine areas and low extremities for 12 h during 5 days. To assess treatment efficacy, scales for measuring @entity615 , @entity5525 , @entity9 (NPS) as well as the Global Impression scale (CGI) and quality of life (EQ-5D) were used. A significant clinical effect was observed in 63% of @entity1 of the main group: the additional reduction of @entity158 by about a quarter, decrease of @entity5525 intensity, improvement of functional activity - spinal flexion-extension, ability to standing and quality of life. The NPS revealed that the use of versatis resulted in the significant decrease of "neuropathic" characteristics of @entity158 ; this effect remained after the end of treatment. The anesthetic effect of plates emerged in 1,2+/-1,1h after application, reached the maximum after 3,8+/-2,0 h, and continued during 4,7+/-2,2 h after removing the plates from the skin. The safety of @entity3303 -coated plates was observed.

title: [The use of @entity3303 -coated plates (versatis) in the treatment of XXXX ].

entities_list: @entity5525 :: ('MESH:C538664', 'Disease') :: ['vertebral syndrome']

entities_list: @entity3522 :: ('MESH:D004008', 'Chemical') :: ['diclofenac']

entities_list: @entity615 :: ('MESH:D001416', 'Disease') :: ['vertebrogenic lumbalgia', 'back pain']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']

answer: @entity615 :: (MESH:D001416,Disease) :: ['back pain']


abstract: INTRODUCTION: Resistance to Carbapenems in Klebsiella may be due to @entity2893 hydrolysing enzymes. Accurate detection of carbapenemase must be done for @entity1 treatment and epidemiological purposes. AIM: To detect carbapenemase production by performing Modified Hodge Test (MHT), @entity1062 ( @entity1062 ) for @entity23041 ( @entity23041 ) and PCR for blaKPC gene, to evaluate the performance of MHT using MacConkey Agar (MCA) and to access the value of MHT for carbapenemase detection. MATERIAL AND METHODS: Using a prospective laboratory study design, 153 Extended Spectrum Beta-Lactamases (ESBL) producing @entity3274 from clinical samples of @entity1 admitted in the Kasturba Medical College were collected from January 2014 to December 2015. Isolates resistant to carbapenems by disk diffusion were subjected to MHT on MCA and @entity23977 ( @entity23977 ). All isolates were tested for ( @entity23041 ) production by Imipenem and Imipenem-EDTA @entity1062 and subjected to PCR for the presence of blaKPC gene. RESULTS: Out of 153 isolates, 54 were resistant to one of the carbapenems. Among these, 13 were positive for MHT on @entity23977 , while 23 were positive by MHT on MCA. Number of @entity23041 producers was 23 (42.5%), while blaKPC was detected in 2 out of the 54 isolates. CONCLUSION: Though detection of drug resistance gene remains the method of choice, it can be performed only in centers with adequate resources. Hence, for most laboratories in resource poor countries, the MHT performed on MCA with concomitant @entity1062 for @entity23041 detection seem to be a better option for detection of @entity2893 resistance.

title: Approach to Carbapenemase Detection in XXXX in Routine Diagnostic Laboratories.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity23977 :: ('MESH:C535871', 'Disease') :: ['MHA', 'Mueller Hinton agar']

entities_list: @entity23041 :: ('MESH:C535600', 'Disease') :: ['MBL', 'Metallo-b-Lactamases']

entities_list: @entity3274 :: ('573', 'Species') :: ['Klebsiella pneumoniae']

entities_list: @entity2893 :: ('CHEBI:46765', 'Chemical') :: ['Carbapenem']

entities_list: @entity1062 :: ('MESH:D013736', 'Disease') :: ['CDT', 'Combined Disk Test']

answer: @entity3274 :: (573,Species) :: ['Klebsiella pneumoniae']


abstract: PURPOSE OF REVIEW: Management of @entity6582 vera and @entity4407 requires understanding of the key concepts regarding diagnosis, risk stratification, and management. RECENT FINDINGS: Essential @entity1148 and @entity6582 vera are among the Philadelphia chromosome negative @entity5 . They are characterized by overproduction of blood cells and their complications include @entity715 , @entity548 , and progression to @entity4018 or @entity3052 ( @entity3052 ). Management of @entity4406 requires recognition of the risk factors for @entity715 and @entity548 . Risk stratification allows the clinician to make a treatment plan that may include antiplatelet therapy with @entity117 alone or in combination with therapeutic phlebotomy in the case of @entity6582 vera, or cytoreductive therapy for high-risk @entity1 with either @entity4407 or @entity6582 vera. Hydroxyurea remains first-line therapy for high-risk @entity1 with @entity4406 , whereas second-line options include @entity18829 , pegylated-IFNa-2a, and the @entity7821 inhibitor @entity26223 . The current evaluation of pegylated- @entity4020 a in global phase II and III studies will provide clarity to the potential long-term benefit and risks associated with this biologic in @entity1 with @entity4406 . Novel therapeutics aimed at prevention of disease progression to @entity4018 / @entity3052 are the focus of current clinical trials. SUMMARY: Risk stratification of @entity1 with @entity4406 by age and/or history of @entity715 provides the basis of risk adapted therapeutic intervention. Aggressive control of modifiable cardiovascular risk factors, the use of antiplatelet agents, control of the hematocrit less than 45% in @entity6582 vera, and cytoreductive therapy in high-risk @entity4406 @entity1 is the focus of management. The exact role of @entity4020 remains undefined and under active investigation, and the recent approval of @entity26223 provides @entity1 with @entity6582 vera a second-line option.

title: Contemporary approach to XXXX and @entity6582 vera.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity6582 :: ('MESH:D011086', 'Disease') :: ['polycythemia']

entities_list: @entity1148 :: ('MESH:D013922', 'Disease') :: ['thrombocythemia']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['myeloproliferative neoplasms']

entities_list: @entity117 :: ('MESH:D001241', 'Chemical') :: ['aspirin']

entities_list: @entity26223 :: ('MESH:C540383', 'Chemical') :: ['ruxolitinib']

entities_list: @entity3052 :: ('MESH:D015470', 'Disease') :: ['acute myeloid leukemia', 'AML']

entities_list: @entity4018 :: ('MESH:D055728', 'Disease') :: ['myelofibrosis']

entities_list: @entity4406 :: ('MESH:D011087', 'Disease') :: ['essential thrombocythemia/polycythemia vera']

entities_list: @entity4407 :: ('MESH:D013920', 'Disease') :: ['essential thrombocythemia']

entities_list: @entity18829 :: ('MESH:C021139', 'Chemical') :: ['anagrelide']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombosis']

answer: @entity4407 :: (MESH:D013920,Disease) :: ['essential thrombocythemia']


abstract: INTRODUCTION: Right @entity2895 ( @entity2895 ) is the most frequently observed complication occurring during cryoballoon ablation (CB). Our aim was to analyze the impact of the premature interruption (PI) of cryoenergy delivery in a large series of consecutive @entity1 during ablation in the right-sided veins on clinical outcome. METHODS AND RESULTS: All consecutive @entity1 having undergone second-generation CB ablation for paroxysmal @entity955 ( @entity955 ) from July 2012 to September 2014 were included in our analysis. Exclusion criteria were persistent @entity955 , presence of an intracavitary @entity715 , uncontrolled @entity712 , moderate or severe @entity340 , left atrium (LA) diameter >= 55 mm, and contraindications to general anesthesia. A total 287 consecutive @entity1 with drug-resistant paroxysmal @entity955 having undergone pulmonary vein isolation by means of CB technology (male 65%, age 57.6    13.1 years) were included. The incidence of @entity2895 in the study population was 8.0% (23/287). At a mean follow-up of 11.5    3.9 months, the success rate without antiarrhythmic therapy was 81.6%. @entity1 with @entity2895 had similar rates of @entity955 recurrence compared with those without @entity2895 (17.4% vs. 17.8%; P = 0.9); the former had a mean follow-up of 10.9    3.7 months, the latter 11.8    4.5 months (P = 0.3). CONCLUSION: Conclusion: Our findings show that @entity1 in whom freezing was interrupted due to @entity2895 had a similar outcome on 1-year follow-up compared with those in whom freezing cycles were completed in the septal veins. No baseline clinical or procedural characteristics were found to predict @entity955 recurrence in @entity1 having experienced @entity2895 .

title: Impact on Clinical Outcome of Premature Interruption of Cryoenergy Delivery Due to Phrenic Nerve Palsy During Second Generation Cryoballoon Ablation for Paroxysmal XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity2895 :: ('MESH:D015840', 'Disease') :: ['PNP', 'phrenic nerve paralysis']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation', 'AF']

entities_list: @entity715 :: ('MESH:D013927', 'Disease') :: ['thrombus']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valvular disease']

answer: @entity955 :: (MESH:D001281,Disease) :: ['Atrial Fibrillation']


abstract: BACKGROUND AND AIMS: Current endoscopic activity scores for ulcerative colitis (UC) do not take into account the extent of mucosal inflammation. We have developed a simple endoscopic index for UC that takes into account the severity and distribution of mucosal inflammation. METHODS: In this multicentre trial, UC @entity1 undergoing colonoscopy were prospectively enrolled. For the Modified Score (MS), the sum of Mayo Endoscopic Subscores (MESs) for five colon segments (ascending, transverse, descending, sigmoid and rectum) was calculated. The Extended Modified Score (EMS) was obtained by multiplying the MS by the maximal extent of inflammation. The Modified Mayo Endoscopic Score (MMES) was obtained by dividing the EMS by the number of segments with active inflammation. Colon biopsies were obtained from the rectum and sigmoid, as well as from all inflamed segments, by standard methods. Clinical activity was scored according to the Partial Mayo Score (PMS). Biological activity was scored according to @entity1851 ( @entity1851 ) and faecal calprotectin (FC) levels. Histological activity was scored according to the Geboes Score (GS). RESULTS: One hundred and seventy-one UC @entity1 (38% female, median age 47 years, median disease duration 13 years) were included. The MMES correlated significantly with the PMS (r = 0.535), @entity1851 (r = 0.238), FC (r = 0.730) and GS (r = 0.615) (all p < 0.001). Median MMES scores were significantly higher in @entity1 with clinical, biological or histological activity (all p  <= 0.001) CONCLUSIONS: The MMES is an easy to use endoscopic index for UC that combines the severity analysis of the @entity32973 with disease extent, and correlates very well with clinical, biological and histological disease activity.

title: The Modified Mayo Endoscopic Score (MMES): A New Index for the Assessment of Extension and Severity of Endoscopic Activity in Ulcerative Colitis XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1851 :: ('1401', 'Gene') :: ['CRP', 'C-reactive protein']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: UNASSIGNED: The @entity995 suppressor pathway is frequently inactivated in @entity1 @entity5 , enabling unrestrained proliferation. Most @entity5 , however, maintain expression of a wild-type (WT) @entity995 suppressor protein ( @entity996 ). It is generally in a hyperphosphorylated state (ppRB) because of mutations in upstream regulators such as @entity986 and cyclin D. Hyperphosphorylated ppRB is considered inactive, although data are emerging that suggest it can retain some function. To test the clinical relevance of @entity996 status, we obtained archival tissue sections from 91 cases of @entity2220 resected between 2003 and 2008. All cases received @entity902 doublet chemotherapy, and the median survival was 5.9 years. All cases were assessed for @entity996 and ppRB using immunohistochemistry and quantified based on intensity of signal and proportion of positive cells. @entity996 expression was lost in 15% of @entity2220 cases. In @entity5 that did not express @entity996 , the survival rate was significantly improved (hazard ratio, 0.21; 95% confidence interval, 0.06-0.69; P = .01) in comparison to @entity5 that express @entity996 . @entity996 status was found to be an independent predictor of overall survival on multivariate analysis (hazard ratio, 0.22; 95% confidence interval, 0.07-0.73; P = .01) along with increased stage and age. @entity996 status did not alter baseline levels of apoptotic or proliferative markers in these @entity5 , but the DNA damage response protein 53 @entity23380 was higher in @entity5 with high levels of @entity996 . In summary, loss of @entity996 expression is associated with improved survival in @entity1 treated with surgical resection and chemotherapy. This may be useful in classifying @entity1 at greatest benefit for aggressive treatment regimes.

title: @entity995 tumor suppressor correlates with improved outcome in XXXX with @entity2220 treated with surgery and chemotherapy.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors', 'cancers', 'cancer']

entities_list: @entity2220 :: ('MESH:C538231', 'Disease') :: ['lung adenocarcinoma']

entities_list: @entity995 :: ('MESH:D012175', 'Disease') :: ['retinoblastoma tumor']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: PURPOSE: This study was conducted to evaluate the association between @entity1984 and mental health status in the general Korean adult population and to investigate the relative burden of @entity1984 on mental health using the @entity2023 and Its Impact on Asthma ( @entity6048 ) classification. METHODS: A cross-sectional study was performed by using data from 11,154 individuals, 19 years old or older in the Korean National Health and Nutrition Examination Survey 2011-2012. Univariate analysis was conducted in the healthy @entity1984 groups with weighted prevalence of demographic characteristics, socioeconomic status, and comorbid diseases. Subanalysis that classified @entity1984 severity according to the @entity6048 classification was carried out to evaluate the relationship of @entity1984 severity with mental health. The odds ratios (ORs) for each component representing mental health status were estimated by multiple logistic regression analysis with confounder adjustment. RESULTS: Univariate analysis with the chi-square test after adjustment for age, sex, body mass index, smoking status, @entity285 use status, and exercise status, components representing mental health status showed a linear relationship with the severity of @entity1984 according to the @entity6048 classification. Stress, @entity308 mood, suicidal thoughts, and psychological consultation factors were correlated with @entity1984 after adjustment for demographic characteristics and socioeconomic status. Even after adjustment for comorbid @entity56 , the correlation remained significant with stress, @entity308 mood, and psychological consultation factors (OR [95% CI]; 1.227 [1.042, 1.445], 1.368 [1.095, 1.71], 1.804 [1.096, 2.969], respectively). CONCLUSIONS: @entity1 with @entity1984 appear to be at higher risk of @entity146 in the general Korean adult population. Moreover, persistent or severe @entity1984 was correlated with poor mental health. Therefore, better control of @entity1984 may be conducive to better mental health, and more attention should be paid to the psychological status of @entity1984 @entity1 .

title: Relationship Between XXXX and Mental Health in the General Korean Adult Population.

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['Allergic Rhinitis']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['mental disorders']

entities_list: @entity56 :: ('MESH:D004342', 'Disease') :: ['allergic diseases']

answer: @entity2023 :: (MESH:D006255,Disease) :: ['Allergic Rhinitis']


abstract: BACKGROUND: Acupuncture was shown to reduce symptoms of @entity2023 ( @entity2023 ). The present study investigated (a) whether autonomic function would differ in @entity2023 @entity1 and healthy controls, and (b) whether acupuncture treatment would evoke changes in autonomic function compared to sham acupuncture. @entity1 AND METHODS: @entity2023 @entity1 (n = 30) were recruited from a larger randomized controlled trial investigating the efficacy of acupuncture in @entity2023 . 21 @entity1 received acupuncture, and 9 @entity1 received sham acupuncture. Among other we measured resting heart rate variability and cardiovascular reactivity to a cold pressure test prior to and after 12 sessions of acupuncture or sham acupuncture. In addition, 30 age- and sex-matched healthy controls were tested once. RESULTS: @entity2023 @entity1 showed higher resting heart rate and lower heart rate variability as well as blunted cardiovascular responses compared to controls. After treatment, resting heart rate had decreased, and systolic blood pressure response to the cold pressure test had increased in @entity2023 @entity1 . We found no significant differences in autonomic function changes between @entity1 receiving acupuncture or sham acupuncture. CONCLUSION: @entity2023 @entity1 showed alterations in autonomic function, which had partially normalized after treatment. However, in this sample we found no specific effect of acupuncture compared to sham acupuncture.

title: Autonomic Function in XXXX and Acupuncture - an Experimental Pilot Study within a Randomized Trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['PATIENTS', 'patients']

entities_list: @entity2023 :: ('MESH:D006255', 'Disease') :: ['SAR', 'seasonal allergic rhinitis']

answer: @entity2023 :: (MESH:D006255,Disease) :: ['Seasonal Allergic Rhinitis']


abstract: OBJECTIVE: To identify the features of @entity309 associated with deterioration resulting in the need for surgical intervention or death. @entity1 AND METHODS: @entity1 with @entity309 who underwent cervical spine magnetic resonance imaging (MRI) between 1991 and 1996 were identified. @entity1 requiring immediate surgical intervention were excluded. The remainder were divided into two groups. Deterioration group: @entity1 requiring surgical intervention during the follow-up period and deaths resulting from cervical @entity602 . Conservative group: all other @entity1 . Relevant clinical features and radiology reports were extracted retrospectively from the casesheet. RESULTS: The deterioration group comprised 11 @entity1 (12%), median time to deterioration 15 months (range 4-84 months). The conservative group included 82 @entity1 . Initial clinical features did not differ significantly between the two groups. Sixty per cent of those @entity1 with compression or impingement at the atlanto-axial level on first MRI deteriorated over a median of 12 months (range 4-36 months). CONCLUSION: Deterioration is likely if there is evidence of cord compromise at the atlanto-axial level on MRI regardless of initial clinical and plain X-ray features.

title: Factors predictive of subsequent deterioration in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['myelopathy']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid cervical myelopathy', 'rheumatoid cervical spine disease']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid cervical myelopathy']


abstract: A 55-year-old @entity1 visited our clinic for rapid swelling of her left breast. The left breast was palpated, and a mass of about 10 cm with thick skin, and multiple lymph nodes in the supraclavicle and axilla were found. PET-CT images showed an increased uptake in her left breast, lymph nodes, spine of TH5, sternum, left lobe of liver, and both lungs. The serum @entity5 markers were also found to be elevated. A core needle biopsy was performed, and the @entity5 was diagnosed as secondary inflammatory @entity189 ( @entity513 ). Immunohistochemical staining showed negative for @entity1722 protein, but strongly positive for ER and @entity7273 . @entity4672 monotherapy administered her starting June, 2008. After 3 months, the @entity3 showed a notable response, which was subsequently maintained for 19 months. The @entity5 markers decreased to the normal range after 6 months, and the multiple @entity3 were not found by PET-CT after 1 year. A radiofrequency ablation operation was conducted on the remaining 3 cm @entity0 . Neoadjuvant endocrine therapy with @entity4672 was shown to be useful for post-menopausal @entity0 @entity1 with strong hormone receptor expression.

title: [A case of secondary inflammatory @entity0 with multiple XXXX in which operation was possible through letrozole monotherapy].

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patients']

entities_list: @entity4672 :: ('MESH:C067431', 'Chemical') :: ['letrozole', 'Letrozole']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity513 :: ('MESH:D044584', 'Disease') :: ['invasive ductal carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases']

answer: @entity3 :: (MESH:D009362,Disease) :: ['metastases']


abstract: BACKGROUND: Although non-adherence to antidepressant medications is a significant barrier to the successful treatment of @entity308 in clinical practice, few potentially modifiable predictors of poor adherence to antidepressant treatment are known. The aim of this study was to examine the relationship of psychological reactance, health locus of control and the sense of self-efficacy on adherence to treatment regimen among @entity146 outpatients with @entity308 . METHODS: One hundred and forty-five consecutive @entity146 outpatients suffering from @entity308 were invited to participate in a cross-sectional study and 119 accepted. @entity1 completed a series of self-reported questionnaires assessing psychological reactance, health locus of control, self-efficacy, and adherence to prescribed medication in addition to socio-demographic and clinical variables. Logistic regression analyses were performed to determine which factors better correlate to treatment adherence. RESULTS: Age was found to be the best correlate of adherence to prescribed treatment. As regards psychological dimension studied, medication adherence was negatively associated with both cognitive and affective psychological reactance; @entity1 with higher psychological reactance were more likely to be noncompliant than @entity1 showing a low level of psychological reactance. Regarding health locus of control, only the external dimension of doctor-attributed health locus of control was positively associated with medications adherence. No effect on adherence was observed for the self-efficacy scale. CONCLUSIONS: Psychological reactance is an important correlate of adherence to treatment in @entity1 with @entity308 and this needs to be considered when giving clinical advice in order to avoid inducing reactance and thus non-adherence to prescribed treatments. Mental health professionals need to learn about communication techniques and counseling skills that enable them to deal with the psychological reactance of their @entity1 .

title: The relationship of psychological reactance, health locus of control and sense of self-efficacy with adherence to treatment in XXXX outpatients with @entity308 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['depressive disorders', 'depression']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity146 :: (MESH:D001523,Disease) :: ['psychiatric']


abstract: UNASSIGNED: The mechanisms of @entity528 after @entity519 - @entity63 (HI) are different in the immature and the adult brain, but microglia activation has not been compared. The purpose of this study was to phenotype resident microglia and blood-derived macrophages in the hippocampus after HI in neonatal (postnatal day 9, P9) or adult (3 months of age, 3mo) @entity19 . Unilateral @entity1545 after HI was induced in @entity21846 (GFP/+) @entity13766 (RFP/+) male @entity19 on P9 (n   =   34) or at 3mo (n   =   53) using the Vannucci model. Resident microglia ( @entity21846 -GFP+) proliferated and were activated earlier after HI in the P9 (1-3 days) than that in the 3mo hippocampus, but remained longer in the adult brain (3-7 days). Blood-derived macrophages ( @entity13766 -RFP+) peaked 3 days after HI in both immature (P9) and adult (3mo) hippocampi but were twice as frequent in adult brains, 41% vs. 21% of all microglia/macrophages. @entity1750 expression was three times higher in the P9 hippocampi, indicating that the proinflammatory response was more pronounced in the immature brain after HI. This corresponded well with the higher numbers of galectin-3-positive resident microglia in the P9 hippocampi, but did not correlate with @entity37871 /32- or @entity8272 -positive resident microglia or blood-derived macrophages. In conclusion, resident microglia, rather than infiltrating blood-derived macrophages, proliferate and are activated earlier in the immature than in the adult brain, but remain increased longer in the adult brain. The inflammatory response is more pronounced in the immature brain, and this correlate well with galectin-3 expression in resident microglia. GLIA 2015;63:2220-2230.

title: Resident microglia, rather than blood-derived macrophages, contribute to the earlier and more pronounced inflammatory reaction in the immature compared with the adult hippocampus after XXXX - @entity63 .

entities_list: @entity1545 :: ('MESH:D020214', 'Disease') :: ['brain injury']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['neuronal injury']

answer: @entity519 :: (MESH:D000860,Disease) :: ['hypoxia']


abstract: The effect of @entity3800 on the oligosaccharide structure of follicle-stimulating hormone (FSH) isoforms was studied in adult male @entity35 treated with a potent @entity1176 (GnRH) antagonist. Animals were castrated (Cx), and 24 h later were treated with physiological doses of either @entity3033 (T) or @entity8048 ( @entity587 ) (0.25 mg/ @entity35 in @entity4336 oil, daily, s.c.) for 7 days. The antiandrogen @entity12194 (F; 5 mg/day/ @entity35 , twice a day, s.c.) was administered to either @entity1619 or Cx- @entity587 @entity35 to block @entity342 action. The GnRH antagonist @entity70538 ( @entity35951 mg/kg/day, s.c.) was injected to both Cx- and Cx- @entity587 treated rats. FSH serum levels reached normal values in Cx @entity35 treated with either T or @entity587 , whereas those treated with F retained Cx conditions. Both Cx-Ant and Cx-Ant- @entity587 treated animals presented normal serum FSH levels. Concanavalin A affinity chromatography was used to isolate pituitary FSH isoforms according to their @entity1735 inner structure. An increased proportion of FSH isoforms bearing complex-type oligosaccharides was observed in Cx @entity35 treated with T or @entity587 , whereas the proportion of these isoforms was reduced in Cx and @entity1619 -F or Cx- @entity587 -F @entity35 . These results demonstrate that functional @entity3800 are needed to complete the oligosaccharide processing of FSH. In addition, the proportion of the different pituitary FSH isoforms after @entity587 replacement was equivalent to that found when @entity1176 action was blocked, indicating that @entity3800 are involved in the regulation of @entity1735 incorporation to the FSH molecule by acting mainly at the pituitary level, independently of GnRH action.

title: Effect of dihydrotestosterone on pituitary follicle-stimulating hormone isoforms in adult male @entity35 treated with a XXXX antagonist.

entities_list: @entity3033 :: ('MESH:D043343', 'Chemical') :: ['testosterone propionate']

entities_list: @entity8048 :: ('MESH:C030445', 'Chemical') :: ['dihydrotestosterone propionate']

entities_list: @entity12194 :: ('MESH:D005485', 'Chemical') :: ['flutamide']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['carbohydrate']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity1176 :: ('MESH:D007987', 'Chemical') :: ['GnRH', 'gonadotropin-releasing hormone']

entities_list: @entity3800 :: ('MESH:D000728', 'Chemical') :: ['androgens']

answer: @entity1176 :: (MESH:D007987,Chemical) :: ['gonadotropin-releasing hormone']


abstract: BACKGROUND: @entity167 exposure during development has been shown to alter a variety of social behaviors in both @entity1 and rodents. Sexual behavior in rodents has been well characterized and lends itself to a detailed investigation of the manner in which @entity1068 impacts this particular social behavior. METHODS: @entity35 were exposed to @entity1068 during both the prenatal and early postnatal period (ET). Control groups included @entity35 exposed to the administration procedures alone (intubated-control) and nontreated controls (NC). Sexual behavior of intact na  ve female @entity35 in estrus was assessed in adulthood (approximately postnatal day 90) and activity was measured by the number of crossings between chambers in the 3-chamber test apparatus. A separate study examined the olfactory preferences for 4 odors by intact na  ve female @entity35 in all 3 groups. The 4 odors were the odors resulting from 1 hour of occupation of the test chamber by an intact male, 1 hour of occupation of the test chamber by a gonadectomized male, 0.5 ml of urine from an intact male, and 0.5 ml of urine from a gonadectomized male. RESULTS: ET female @entity35 showed a reduced return latency after ejaculation compared to both control groups. There was a trend toward a reduction in percent exits after all forms of male behavior in the ET animals compared to the control groups. No significant differences across groups were seen in the @entity1515 quotient, activity, or the behavior of the nonexperimental male. ET female @entity35 showed a reduced preference for the odor from the intact male compared to both control groups and a reduced preference for the odor from the gonadectomized male compared to NC females only. CONCLUSIONS: These data suggest that @entity1068 exposure during the prenatal and postnatal period in females alters sexual motivation and changes the processing of olfactory cues and possibly coital cues from male @entity35 .

title: XXXX exposure during development: analysis of effects on female sexual behavior.

entities_list: @entity167 :: ('CHEBI:16236', 'Chemical') :: ['Alcohol']

answer: @entity167 :: (CHEBI:16236,Chemical) :: ['Alcohol']


abstract: This paper describes the findings of an ethnographic study that sought to explore the influence of @entity645 / @entity791 on the practice of primary care nurses in Jordan. The study was undertaken in three (3) rural and three (3) urban comprehensive primary health care centres. Data collection included @entity1 observation, key informant interviews, field notation and document analysis. These data informed the development of descriptive ethnographic accounts that allowed for the subsequent identification of common and divergent themes reflective of factors recognized as influencing the practice of nurses. The findings indicate that the ability of the nurses to raise awareness and therefore reduce the spread of @entity645 / @entity791 is unrealistic. Data shows that the population is at risk because the nurses' knowledge and skill base is inadequate and the health care facilities are crippled by limited @entity1 and physical resources. Poor management and the lack of localised leadership are also factors identified as contributing to the vulnerability of Jordanians. Enhanced commitment from the Ministry of Health and the senior nursing administration in Jordan is required if the comprehensive primary health care centres are to meet expectations and improve health outcomes of the population. Funding must be directed to improve the infrastructure of the comprehensive primary health care centres and adequate concurrent funds provided for the purchase of non-capital items. It is crucial that support be made available to up-skill the nursing staff and superior recruitment and retention initiatives implemented to address the current nursing shortages.

title: Jordan's vulnerability: a population at risk of @entity645 / XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'participant']

answer: @entity791 :: (MESH:D000163,Disease) :: ['AIDS']


abstract: BACKGROUND: In a new health care economy, there is an emerging need to understand and quantify predictors of @entity572 ( @entity572 ) outcomes. We investigated the association between preoperative radiographic disease (as measured quantitatively by joint space width [JSW]) and @entity1 -reported function, activity, @entity158 , and quality of life after @entity572 . METHODS: We retrospectively analyzed 146 @entity1 (146 hips) 55 years or younger with a diagnosis of @entity571 who underwent cementless @entity572 between January 2009 and December 2010. Preoperative pelvic radiographs were measured by 1 author blinded to clinical outcomes to establish JSW, defined as the shortest distance between the femoral head margin and the superolateral weight-bearing portion of the acetabulum. The JSW value was treated as a continuous variable when applied to statistical modeling. The relationship between the JSW and the improvement of clinical outcome was examined via a general linear modeling approach with adjustments for @entity1 ' age, body mass index, and sex. RESULTS: We identified an inverse relationship between preoperative JSW and improvements in functional, activity, @entity158 , and quality of life. We found that, as JSW decreased by 1 mm, the outcome measure improvements were modified Harris Hip Score of 6.3 (p<0.001); SF-12 physical: 2.1 (p=0.027); WOMAC- @entity158 : 4.8 (p=0.01); and UCLA Activity: 0.44 (p=0.02). CONCLUSIONS: Our results demonstrate that @entity1 with greater preoperative joint space have less predictable improvement in terms of function, @entity158 relief, and activity. These findings suggest that @entity572 in young @entity1 with a JSW less than 1.5 to 2 mm provides more predictable improvements in @entity158 and functional outcomes.

title: Preoperative Joint Space Width Predicts XXXX -Reported Outcomes After Total Hip Arthroplasty in Young @entity1 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity572 :: ('MESH:D006617', 'Disease') :: ['THA', 'total hip arthroplasty']

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis']

answer: @entity1 :: (9606,Species) :: ['Patient']


abstract: BACKGROUND: The role of endoscopy in the management of malignant-pedunculated @entity1127 has been well studied, but endoscopic management of @entity1127 has not. Sometimes @entity1 with @entity1127 have comorbidities that make surgery exceptionally risky, and endoscopy beckons as a definitive management option. The aim of this study is to evaluate the potential role of endoscopy in the management of @entity1127 . METHODS: @entity1 undergoing colonoscopic polypectomy for @entity1127 by a single endoscopist from 1997 to 2010 were evaluated. Demographic data, clinicopathological variables as well as long-term outcomes were recorded. RESULTS: Sixteen @entity1 had @entity1127 . Six (37.5  %) were male and 10 (62.5  %) were female. Mean age at diagnosis was 72.9      12.2  years. Six @entity1127 were proximal to the @entity4558 (37.5  %) and 10 (62.5  %) were distal. The mean size of the @entity1127 was 30.5      15.9  mm. All @entity1127 were removed endoscopically but 7 @entity1 (43.8  %) had formal colectomy following colonoscopic resection. There were no demographic differences between @entity1 with and without surgery. Piecemeal polypectomy was necessary in 8 @entity1 , 4 from the surgery group, and 4 from the endoscopy group. More @entity1 in the surgery group had poorly differentiated @entity5 (4/6 vs. 0/6) and incomplete margins (5/6 vs. 1/6) and more @entity1 in the endoscopically treated group had serious comorbidity (5/9 vs. 3/7). There was no procedure-related morbidity or mortality. After a mean follow-up of 48.4      27.2  months, one @entity1 from the polypectomy group @entity1 had a local recurrence and a liver @entity3 , after originally declining surgery. In the surgery group, one @entity1 had lung @entity3 . The two @entity1 who recurred with distant @entity3 died. CONCLUSION: Endoscopic management of sessile @entity1127 appears to be feasible and safe in @entity1 with well/moderately differentiated @entity5 and negative margins. Larger studies are needed to confirm these findings.

title: Management of sessile malignant XXXX : is colonoscopic polypectomy enough?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1127 :: ('MESH:D011127', 'Disease') :: ['colorectal polyps', 'polyps', 'malignant sessile polyps']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer']

entities_list: @entity4558 :: ('MESH:D013158', 'Disease') :: ['splenic flexure']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity1127 :: (MESH:D011127,Disease) :: ['polyps']


abstract: UNASSIGNED: Dysregulation of microRNAs (miRNAs) is actively involved in the pathogenesis and tumorigenicity of @entity157 ( @entity157 ). @entity61833 was found to play either oncogenic or @entity5 suppressive roles in @entity1 @entity5 . Recent study reported that the levels of @entity61833 in late recurrent @entity157 @entity1 were evidently higher than that in early recurrent cases, suggesting that @entity61833 may function as a @entity5 suppressive miRNA in @entity157 . Yet, the clinical value and biological function of @entity61833 remain rarely known in @entity157 . Here, we presented that @entity61833 level in @entity157 tissues was notably reduced compared to matched non-cancerous specimens. Its decreased level was evidently correlated with adverse clinical parameters and poor prognosis of @entity157 @entity1 . Accordingly, the levels of @entity61833 were obviously down-regulated in @entity157 cells. Ectopic expression of @entity61833 in HCCLM3 and MHCC97H cells prominently inhibits the migration and invasion of @entity5 cells and reduced lung metastases in vivo, while @entity61833 knockdown increased these behaviors of HepG2 and MHCC97L cells. Mechanically, @entity61833 negatively regulated @entity1917 ( @entity1917 ) abundance in @entity157 cells. Herein, @entity1917 was found to be a downstream molecule of @entity61833 in @entity157 . An inversely correlation between @entity61833 and @entity1917 was confirmed in @entity157 specimens. @entity1917 knockdown prohibited cell migration and invasion while @entity1917 overexpression showed opposite effects on @entity157 cells. Furthermore, restoration of @entity1917 expression could abrogate the anti-metastatic effects of @entity61833 on HCCLM3 cells with enhanced cell migration and invasion. Altogether, @entity61833 potentially acts as a prognostic predictor and a drug-target for @entity157 @entity1 .

title: microRNA-489 Plays an Anti-Metastatic Role in XXXX @entity157 by Targeting @entity1917 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity1917 :: ('4316', 'Gene') :: ['matrix metalloproteinase-7', 'MMP7']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancers']

entities_list: @entity157 :: ('MESH:D006528', 'Disease') :: ['HCC', 'hepatocellular carcinoma']

answer: @entity1 :: (9606,Species) :: ['Human']


abstract: UNASSIGNED: Although historically restricted from combat roles, @entity1 suffer from combat-related @entity130 , especially in recent conflicts where asymmetrical warfare erases distinctions between forward and rear operating areas. U.S. servicewomen who sustained combat-related injury in @entity7441 ( @entity7441 ) or @entity7441 ( @entity7441 ) between January 2003 and May 2014 were identified from the Expeditionary Medical Encounter Database. Injuries were characterized using Abbreviated Injury Scale and International Classification of Diseases, 9th Revision codes. Of the 844 combat-related @entity130 in @entity1 , 51% (n = 433) were @entity130 and 49% (n = 411) were @entity130 . Blast events were responsible for 90% of @entity130 . The average Injury Severity Score was 3, with no statistical difference in means between @entity7441 and @entity7441 . Of significance were @entity542 in @entity7441 compared with @entity7441 (80% vs. 48%; p < 0.001). Although the majority of combat-related @entity130 suffered by @entity1 were mild, some @entity1 suffered life-threatening @entity130 , and nearly 65% of the @entity130 resulted in more than one injury. More research is needed as the roles of @entity1 in the military continue to expand. Future studies will investigate quality of life outcomes and gender differences in combat-related @entity130 .

title: Characterization and Comparison of Combat-Related Injuries in XXXX During @entity7441 and @entity7441 .

entities_list: @entity7441 :: ('MESH:D056987', 'Disease') :: ['OIF', 'Operation Iraqi Freedom', 'Operation Enduring Freedom', 'OEF']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['increased head injuries']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['OIF injuries', 'injuries', 'injury episodes', 'OEF injuries']

answer: @entity1 :: (9606,Species) :: ['Women']


abstract: BACKGROUND: Emotional reactions of couples were investigated during @entity52 ( @entity52 ) at a private clinic in Sweden. The purpose was to compare such reactions between couples who obtained supernumerary embryos that could be cryopreserved and couples without such embryos. METHODS: Forty @entity1 and @entity1 undergoing @entity52 treatment monitored individually their emotional reactions daily for one complete treatment cycle from the first day of down-regulation until the outcome of treatment was known. Ratings were extracted and analyzed from two separate days; the very first day of treatment and the day of embryo transfer. RESULTS: The group of @entity1 (n=16; 40%) with supernumerary embryos suitable for cryopreservation reported a greater increase in optimism than the group (n=24; 60%) without such embryos (p=0.024). Correspondingly, @entity1 with supernumerary embryos reported less pessimism than @entity1 without such embryos (p=0.014). Among @entity1 there was no difference in optimism or pessimism between the groups. The @entity1 and @entity1 with supernumerary embryos did not differ in distress reactions compared to those @entity1 and @entity1 without such embryos. There was no correlation between optimism and distress on the day of embryo transfer in @entity1 ; r=-0.167 and @entity1 ; r=-0.135 respectively. CONCLUSION: The presence of frozen embryos increased optimistic and reduced pessimistic feelings about pregnancy among @entity1 undergoing @entity52 treatment. However, the couples' increased optimism on the day of embryo transfer did not seem to reduce their experience of distress.

title: The impact of frozen embryos on emotional reactions during XXXX .

entities_list: @entity52 :: ('MESH:C566179', 'Disease') :: ['IVF', 'in vitro fertilization']

answer: @entity52 :: (MESH:C566179,Disease) :: ['in vitro fertilization']


abstract: PURPOSE: To determine whether serum levels of @entity518 ( @entity518 ) could differentiate @entity3620 @entity1 , @entity1355 -exposed individuals, and unexposed controls. EXPERIMENTAL DESIGN: Hyperacetylated and nonacetylated @entity518 (together referred to as total @entity518 ) were blindly measured in blood collected from @entity3620 @entity1 (n= 22), individuals with verified chronic @entity1355 exposure (n= 20), @entity1 with benign @entity1143 (n= 13) or @entity3483 not due to @entity3620 (n= 25), and healthy controls (n= 20). Blood levels of previously proposed @entity3620 biomarkers @entity21378 , mesothelin, and @entity1096 were also measured in nonhealthy individuals. RESULTS: @entity518 serum levels reliably distinguished @entity3620 @entity1 , @entity1355 -exposed individuals, and unexposed controls. Total @entity518 was significantly higher in @entity3620 @entity1 and @entity1355 -exposed individuals compared with healthy controls. Hyperacetylated @entity518 was significantly higher in @entity3620 @entity1 compared with @entity1355 -exposed individuals and healthy controls, and did not vary with @entity5 stage. At the cut-off value of 2.00 ng/mL, the sensitivity and specificity of serum hyperacetylated @entity518 in differentiating @entity3620 @entity1 from @entity1355 -exposed individuals and healthy controls was 100%, outperforming other previously proposed biomarkers. Combining @entity518 and @entity21378 provided increased sensitivity and specificity in differentiating @entity3620 @entity1 from @entity1 with cytologically benign or malignant non- @entity2615 @entity1143 . CONCLUSIONS: Our results are significant and clinically relevant as they provide the first biomarker of @entity1355 exposure and indicate that hyperacetylated @entity518 is an accurate biomarker to differentiate @entity3620 @entity1 from individuals occupationally exposed to @entity1355 and unexposed controls. A trial to independently validate these findings will start soon.Clin Cancer Res; 1-10.   2016 AACR.

title: @entity518 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify @entity2615 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity518 :: ('3146', 'Gene') :: ['high mobility group box protein 1', 'HMGB1']

entities_list: @entity1143 :: ('MESH:D010996', 'Disease') :: ['pleural effusions', 'pleural effusion']

entities_list: @entity2615 :: ('MESH:D008654', 'Disease') :: ['mesothelioma']

entities_list: @entity3620 :: ('MESH:C562839', 'Disease') :: ['malignant mesothelioma']

entities_list: @entity3483 :: ('MESH:D016066', 'Disease') :: ['malignant pleural effusions']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: OBJECTIVE: To summarize the application of protective terminal ileostomy in laparoscopic total mesorectal excision for @entity5 @entity1 , and explore the risk factors associated with @entity260 and timing of stoma closure. METHODS: Clinical data of 77 @entity1 with middle or low @entity5 undergoing laparoscopic total mesorectal excision (TME) with preventive terminal ileostomy in our department from January 2007 to December 2013 were retrospectively analyzed. Independent risk factors associated to @entity260 of terminal ileostomy were examined by logistic regression and timing of stoma closure was investigated. RESULT: The total postoperative complication morbidity was 57.1%(44/77). Electrolyte disturbance was found in 39 cases (50.6%, 39/77), including 1 case of @entity1163 . @entity547 occurred in 9 cases (11.7%, 9/77). @entity1909 and @entity733 was observed in 1 case (1.3%, 1/77). The result of the single factor analysis of the water electrolyte disturbance after operation, the risk factors of P<0.2 were new adjuvant chemotherapy (P=0.094), @entity5 antigen (P=0.086) and TNM staging (P=0.026); @entity86 hernia of the single factor analysis results, the risk factors of P<0.2 included uses of antidiabetic drugs (P=0.172), ASA anesthesia (P=0.168) grading and TNM stage(P=0.161); But multivariate analysis revealed no risk factors associated with the above complications (all P>0.05). Sixty-five @entity1 underwent stoma closure during follow-up, including 2 cases (3.1%) within 90 days, 20 cases (30.8%) from 90 to 180 days, and 43 cases (66.2%) more than 180 days. CONCLUSIONS: No risk factors were found to be associated with @entity260 of protective terminal ileostomy after laparoscopic TME for @entity5 @entity1 , such as electrolytes imbalance and @entity547 . The timing of stoma closure should be longer than 180 days.

title: [Risk factor analysis on XXXX after laparoscopic total mesorectal excision with preventive terminal ileostomy and timing of stoma closure in @entity5 ].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'rectal cancer']

entities_list: @entity1163 :: ('MESH:D013575', 'Disease') :: ['hypovolemic syncope']

entities_list: @entity260 :: ('MESH:D011183', 'Disease') :: ['main postoperative complications', 'postoperative complications']

entities_list: @entity733 :: ('MESH:D000038', 'Disease') :: ['subcutaneous abscess']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['Postoperative parastomal']

entities_list: @entity547 :: ('MESH:D006547', 'Disease') :: ['Parastomal hernia', 'parastomal hernia']

entities_list: @entity1909 :: ('MESH:D003872', 'Disease') :: ['Peristomal dermatitis']

answer: @entity260 :: (MESH:D011183,Disease) :: ['postoperative complications']


abstract: STUDY DESIGN: Retrospective clinical study. OBJECTIVE: To retrospectively evaluate the safety and efficacy of one-stage spinal osteotomy in the treatment of severe and progressive @entity1635 ( @entity1635 ) associated with @entity602 ( @entity602 ). SUMMARY OF BACKGROUND DATA: For severe and @entity2003 , @entity4681 are often advocated for correcting the deformity. However, the safety and efficacy of one-stage spinal osteotomy in the treatment of severe and rigid @entity1635 with @entity602 have been unclear thus far. METHODS: @entity1 were treated by one-stage spinal osteotomy between September 2007 and June 2011 in our hospital. The clinical records were reviewed for demographic and radiographical data, operative time, intraoperative @entity190 , blood transfusion, perioperative complications, and functional outcomes. RESULTS: There were 18 females and 11 males with an average age of 15.5    3.6 years (range, 12-28 yr). Spinal cord was longitudinally split by a @entity5040 in 11 @entity1 (type I @entity602 ) and by a fibrous band in 18 @entity1 (type II @entity602 ). @entity1 were observed for a minimum of 24 months after initial surgical treatment with an average follow-up of 43.0    17.1 months (range 24-68 mo) from September 2007 to June 2013. The mean operative time and average @entity190 of type ISSCM was significantly greater than those of type II @entity602 (P < 0.05). The major curve was corrected from an average of 97.2     17.8   to 35.7     15.9  , a mean correction rate of 64.3%    11.0%. The average loss of correction at final follow-up was 2.9% for major curves. The overall complication rate was 24.1%, including transient @entity16 in 3 @entity1 , cerebrospinal fluid leakage in 2 @entity1 , @entity293 in 1 @entity1 and @entity397 in 1 @entity1 . CONCLUSION: Relative to multistage corrective surgery, one-stage spinal osteotomy is effective for the correction of severe @entity1635 and @entity602 without increasing the rate of surgical complications. However, surgical treatment of type I @entity602 does require more operating time and @entity190 . LEVEL OF EVIDENCE: 4.

title: Safety and Efficacy of One-stage Spinal Osteotomy for Severe and Rigid @entity1635 Associated with Split XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity2003 :: ('MESH:D009127', 'Disease') :: ['rigid spinal deformity']

entities_list: @entity190 :: ('MESH:D006473', 'Disease') :: ['blood loss']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['SSCM', 'split spinal cord malformation']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological deterioration']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['CS', 'congenital scoliosis']

entities_list: @entity4681 :: ('MESH:D016472', 'Disease') :: ['spinal osteotomies']

entities_list: @entity397 :: ('MESH:D012421', 'Disease') :: ['pleural rupture']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection']

answer: @entity602 :: (MESH:D013118,Disease) :: ['Spinal Cord Malformation']