abstract: UNASSIGNED: Abstract Background: @entity5018 ( @entity12690 ) is an efficacious over-the-counter analgesic/antipyretic with adverse event (AE) rates comparable to placebo. @entity12690 @entity1372 (IBUNa) is a newer, more soluble form that is absorbed faster than standard @entity12690 , leading to more rapid analgesia. Although its safety and tolerability are expected to be comparable to standard @entity12690 , this has not yet been reported. Methods: Pooled analysis comparing the safety of single-dose IBUNa (512 mg; equivalent to 400 mg @entity12690 free acid; n = 362) with standard @entity12690 tablets (400 mg; n = 342) and placebo (n = 187) across five Phase III, randomized, placebo-controlled, double-blind studies evaluating IBUNa for treatment of postoperative dental @entity158 , @entity2701 , or @entity221 . Results: Treatment-emergent AEs (TEAEs) occurred in 5% of cases in the IBUNa group (25 events), 6.4% of cases in the standard @entity12690 group (41 events), and 10.2% of cases in the placebo group (31 events). The most frequent TEAEs were in the following Medical Dictionary for Regulatory Activities (MedDRA) System Organ Classes: @entity344 (2.8, 3.2, and 5.9% for IBUNa, standard @entity12690 , and placebo, respectively), @entity3002 (1.4, 3.5, and 3.7% for IBUNa, standard @entity12690 , and placebo, respectively), and general disorders and administration-site conditions (1.1, 1.5, and 2.1% for IBUNa, standard @entity12690 , and placebo, respectively). @entity390 was the most common TEAE (2.5, 2.6, and 5.9% for IBUNa, standard @entity12690 , and placebo, respectively). Only two AEs were considered related to treatment: @entity111 (n = 1, IBUNa) and @entity390 (n = 1, placebo). Of those subjects reporting >=  1 TEAE, 44.4, 36.4, and 89.5% of subjects in the IBUNa, standard @entity12690 , and placebo groups, respectively, received rescue medication. Conclusion: IBUNa has a favorable safety profile comparable to those of standard @entity12690 tablets and placebo in single-dose studies evaluating analgesic or antipyretic efficacy. ClinicalTrials.gov Registry Numbers: Dental @entity158 studies: NCT01098747 and NCT01216163; @entity10 studies: NCT01077973 and NCT01362491; pyresis study: NCT01035346.

title: Safety of a novel formulation of XXXX sodium compared with standard @entity5018 and placebo.

entities_list: @entity390 :: ('MESH:D009325', 'Disease') :: ['Nausea', 'nausea']

entities_list: @entity5018 :: ('MESH:D007052', 'Chemical') :: ['Ibuprofen']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal disorders']

entities_list: @entity3002 :: ('MESH:D009421', 'Disease') :: ['nervous system disorders']

entities_list: @entity111 :: ('MESH:D011537', 'Disease') :: ['pruritus']

entities_list: @entity2701 :: ('MESH:D018781', 'Disease') :: ['tension-type headache']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

answer: @entity5018 :: (MESH:D007052,Chemical) :: ['ibuprofen']


abstract: BACKGROUND: Insulin resistance is associated with @entity731 , but its mechanism is unknown. It has been reported that @entity3241 deficient ( @entity3241 -/-) @entity19 showed insulin resistance without @entity164 2 @entity6 , whereas the @entity3238 deficient ( @entity3238 -/-) @entity19 showed insulin resistance with @entity164 2 @entity6 . METHODS AND RESULTS: We investigated @entity8233 formation in the @entity3241 -/- and @entity3238 -/- @entity19 at 8 and 20 weeks. The @entity3238 -/- @entity19 showed much greater @entity8233 formation than the @entity3241 -/- and wild- @entity164 @entity19 at 8 weeks. At 20 weeks, the @entity3238 -/- @entity19 had greater @entity8233 formation than the @entity3241 -/- @entity19 , which showed more enhanced @entity8233 formation than the wild- @entity164 @entity19 . The @entity3241 -/- and @entity3238 -/- @entity19 had @entity2299 , @entity101 , and insulin resistance. The @entity3238 -/- @entity19 had more @entity209 than the @entity3241 -/- @entity19 at 8 and 20 weeks. @entity3238 expression was detected, but @entity3241 expression was not detected in the vessels. CONCLUSIONS: The @entity8233 formation in the @entity3241 -/- and @entity3238 -/- @entity19 appears to be related to abnormalities induced by the altered metabolic milieu in insulin-resistant states. Moreover, because @entity8233 formation was much greater in the @entity3238 -/- @entity19 than in the @entity3241 -/- @entity19 at 8 and 20 weeks, it is suggested that a lack of @entity3238 renders the vasculature more susceptible to injury in the abnormal metabolic milieu, and @entity3238 may have a protective effect on @entity8233 formation. We conclude that @entity3238 is protective and retards the development of @entity8233 formation in insulin-resistant states.

title: Lack of @entity3238 causes progressive XXXX .

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity2299 :: ('MESH:D050171', 'Disease') :: ['dyslipidemia']

entities_list: @entity8233 :: ('MESH:D058426', 'Disease') :: ['neointima']

entities_list: @entity209 :: ('MESH:D008659', 'Disease') :: ['metabolic abnormalities']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity3241 :: ('16367(Tax:10090)', 'Gene') :: ['insulin receptor substrate (IRS)-1', 'IRS-1']

answer: @entity8233 :: (MESH:D058426,Disease) :: ['neointima formation in response to vessel injury']


abstract: OBJECTIVE: There are a few long-term follow-up studies of @entity1 with @entity43 . The objective of this study was to evaluate prognostic factors for long-term survival. METHODS: Two hundred fourteen @entity43 (registered by the Tokai @entity43 Study Group from 1988 to 1999) were analyzed. Staging according to the International Federation of Gynecology and Obstetrics was set without considering the pathologic findings of the lymph nodes. Stage Ic was divided into Ic(b) and other Ic. RESULTS: Seventy-four @entity1 were stage Ia, 2 were stage Ib, and 138 were stage Ic, consisting of 75 Ic(b) and 63 other Ic @entity1 . The ratios of stage Ic to Ia and stage Ic(b) to Ic were highest in clear-cell @entity420 among histologies analyzed. There were significant differences in disease-free survival curves between each group. In @entity16488 , there was a significant difference in disease- free survival curves between stage Ic(b) and other Ic (p = 0.0373), while this tendency was also observed in other histologies except for @entity189 . Multivariate analysis demonstrated that substage was a significant prognostic factor of both disease-free and overall survival. CONCLUSIONS: Stage Ic(b) @entity1 showed poorer survival than stage Ia @entity1 but better than survival in other Ic. Thus, cautious treatment of @entity43 during surgery is quite important to avoid @entity397 .

title: Long-term prognosis of @entity43 . Prognostic importance of intraoperative XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity16488 :: ('MESH:D018262', 'Disease') :: ['clear cell adenocarcinoma']

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['Ovarian Tumor', 'ovarian tumor', 'stage I ovarian carcinoma', 'stage I ovarian carcinomas']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['mucinous carcinoma']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity397 :: (MESH:D012421,Disease) :: ['rupture']


abstract: The aim of this study was to determine how @entity561 ( @entity16292 ) alters cartilage @entity79 in a @entity95 anterior cruciate ligament transection (ACLT) model of @entity571 ( @entity571 ). Thirty @entity95 underwent an ACLT on the left knee and a sham operation on the right knee. Fifteen @entity95 received weekly subcutaneous injections of @entity16292 (0.14   mg/kg) and 15 @entity95 (the control [cont] group) received saline. Animal knees were divided into four groups: cont/sham, cont/ACLT, @entity16292 /sham, and @entity16292 /ACLT. Histological, radiological, and immunohistochemical indices were evaluated for each group. Bone volume ratios by micro-computed tomography showed that @entity16292 prevented periarticular @entity604 . Histologically, the cont/ACLT group had significantly worse @entity16 than the cont/sham group 12 weeks after the surgery. However, the @entity16292 /ACLT group had mild @entity528 compared with that of the @entity16292 /sham group. Immunohistochemical analysis showed that @entity16292 suppressed the expression of @entity28477 , @entity20573 , type-X collagen, vascular endothelial growth factor, and receptor activator of nuclear factor kB ligand in @entity571 cartilage. @entity16292 had a chondroprotective effect in an experimental @entity95 model of @entity571 .

title: Chondroprotective effect of @entity561 in a XXXX model of @entity571 .

entities_list: @entity571 :: ('MESH:D010003', 'Disease') :: ['osteoarthritis', 'OA']

entities_list: @entity561 :: ('MESH:D019386', 'Chemical') :: ['alendronate']

entities_list: @entity604 :: ('MESH:D016301', 'Disease') :: ['bone loss']

entities_list: @entity95 :: ('9986', 'Species') :: ['rabbits', 'rabbit']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['cartilage damage']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['degeneration and periarticular bone quality']

entities_list: @entity528 :: ('MESH:D009410', 'Disease') :: ['cartilage degeneration']

answer: @entity95 :: (9986,Species) :: ['rabbit']


abstract: UNASSIGNED: Purpose. To compare the outcomes of external dacryocystorhinostomy (E-DCR) by using two different @entity1912 anastomosis patterns and skin incision types. Methods. This study included 79 @entity1 (88 eyes) with lacrimal @entity74 who underwent E-DCR surgery. Fifty eyes of 44 @entity1 (group A) underwent E-DCR by suturing anterior and posterior flaps (H- @entity1912 ) of the lacrimal sac with curvilinear skin incision whereas in 38 eyes of 35 @entity1 (group B) DCR was performed by suturing only anterior flaps (U- @entity1912 ) with W skin incision. Results. The success rate was evaluated according to lacrimal patency and scar assessment scores. Patency was achieved in 78 @entity1 (88.6%). In terms of groups, patency was 44 eyes (88.0%) in group A and 34 eyes (89.5%) in group B. There was no statistically significant difference in the success rates of lacrimal patency between the two groups. Further, there was no statistically significant difference concerning cutaneous scar scores. Conclusion. Our study suggests that anastomoses of only anterior flaps or both anterior and posterior flaps have similar success rates; suturing only anterior flaps is easier to perform and shortens the operative time. In addition, W skin incision is a reasonable alternative to curvilinear incision for reducing scar formation.

title: Comparison of Modifications in @entity1912 Anastomosis Patterns and Skin Incision Types for External Dacryocystorhinostomy: Anterior-Only @entity1912 Anastomosis with W Skin Incision versus Anterior and Posterior XXXX Anastomosis with Linear Skin Incision.

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['drainage system disorders']

answer: @entity1912 :: (241,Gene) :: ['Flap']


abstract: OBJECTIVE: To assess the risk of @entity281 in @entity130 @entity1 undergoing surgical intervention with instrumentation for @entity174 . DATA SOURCES: A case series of 235 consecutive @entity1 who sustained @entity174 seen at Tampa General Hospital in Tampa, Florida between 1986 and 1997. STUDY SELECTION: 117 @entity1 of the 235 consecutive @entity1 included in the case series underwent surgical intervention; of these @entity1 , twelve were identified as having @entity6081 . DATA EXTRACTION: Of those @entity1 treated with operative decompression and internal fixation, the authors identified and studied those with an acute wound @entity281 . These @entity1 were analyzed for risk factors and @entity281 management. DATA SYNTHESIS: Twelve (10 percent) @entity1 with @entity6081 were identified. These included nine deep and three superficial @entity281 . This provides an overall @entity281 rate of 10 percent (12 of 117). Of these, there were three @entity281 in twenty-one @entity1 undergoing anterior spinal procedures. Only two of the twelve @entity1 had pure cultures of gram-positive organisms (2 @entity794 ). Cultures from eight (67 percent) @entity1 showed multiple organisms. There was a significantly (P < 0.05) higher risk of @entity281 in the @entity1 with a complete @entity16 41 percent (7/17) as compared with those with no deficit or incomplete injuries 5.0 percent (5/100). CONCLUSIONS: The overall risk of @entity281 is higher in the @entity130 @entity1 than in the elective surgery population. Those @entity1 with a @entity51 are at a greater risk. @entity146 and early intervention can help contribute to a favorable outcome.

title: Postoperative wound @entity281 after instrumentation of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity6081 :: ('MESH:D013530', 'Disease') :: ['acute postoperative wound infections']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['thoracic and lumbar fractures']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['Aggressive']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurologic injury']

entities_list: @entity794 :: ('1280', 'Species') :: ['Staphylococcus aureus']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection', 'infections']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['complete neurologic deficit']

answer: @entity174 :: (MESH:D050723,Disease) :: ['thoracic and lumbar fractures']


abstract: BACKGROUND: The increasing prevalence of @entity28 is considered a serious global health threat. Mainly due to change of diet and reduced physical activity, @entity28 is an important risk factor for @entity102 . A higher level of cytokines and a general inflammatory state has also been associated with this condition. With this regard, potential anti- @entity28 compounds with anti-inflammatory properties could be beneficial in better control of the disease. @entity26878 is a natural aromatic compound that has been shown to have anti-inflammatory properties, while the antidiabetic drug @entity2449 has been observed to be effective as an aid for @entity353 . In this study, the effect of these comounds was compared in a high fat diet treated @entity19 model. METHODS: 48 adult NMRI @entity19 were randomly divided into six groups: control group receiving a normal diet, high fat diet (HFD) fed control group, sham group receiving HFD and sunflower seed oil, Experimental group1 (E1) receiving HFD and 20  mg/kg @entity2449 , Experimental group2 (E2) receiving 20  mg/kg @entity2449 and 20  mg/kg @entity26878 , Experimental group3 (E3) receiving 20  mg/kg @entity26878 . Compounds were administered by intragastric gavage for 45  days. RESULTS: Non-fasting @entity413 serum levels, ALT, and ALP of E2 and E3 decreased significantly compared to HFD control group. In the E3 group, AST levels decrease was also significant. In E1, non-fasting @entity413 and TG serum levels decreased significantly compared to HFD control group. Histological observations on liver tissue showed an increase of lipid droplets in the HFD control group compared with the normal group, while upon treatment with the compounds, lipid droplets decreased and the cells appeared to be more ordered. CONCLUSION: @entity26878 has a potential to ameliorate biochemical parameters in high fat diet treated @entity19 , and its concurrent use with @entity2449 was effective.

title: Cymene and XXXX treatment effect on biochemical parameters of male NMRI @entity19 fed with high fat diet.

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity102 :: ('MESH:D002908', 'Disease') :: ['chronic diseases']

entities_list: @entity26878 :: ('MESH:C007210', 'Chemical') :: ['p-Cymene', 'p-cymene']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity2449 :: ('MESH:D008687', 'Chemical') :: ['metformin']

answer: @entity2449 :: (MESH:D008687,Chemical) :: ['Metformin']


abstract: We compared peripheral nerve fibers and muscle fibers in @entity3918 ( @entity3918 ) using a computer-assisted device for morphometry. In the 17 cases with @entity3918 studied, the sural nerves of 14 cases (82%) showed various degrees of @entity17 (MSA) per endoneurial area. Of these, 8 cases (47%) presented with a mild @entity17 , 5 cases (29.4%) with moderate reduction, and one case (6%) with severe reduction. The number of myelinated nerve fibers was not significantly reduced in @entity3918 when compared with control nerves, due to clusters of small regenerated nerve fibers. The mean diameter of the muscle fibers in 6 of the 17 cases was less than 40 microm. Of these 6 severely affected cases, 5 revealed a considerable @entity17 . Other cases, which appeared to be normal in respect to the diameter of muscle fibers, showed various degrees of @entity17 . Thus, there is usually, but not always a morphometric correlation of the severity of changes between peripheral nerves and muscle. The severity of the @entity1897 appears to depend largely on the @entity1 's age, the stage of the disorder, and the time of progression. Electron microscopic examination of sural nerves showed significant, though non-specific pathological changes.

title: Comparative morphometric evaluation of peripheral nerves and muscle fibers in XXXX .

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['peripheral neuropathy']

entities_list: @entity3918 :: ('MESH:D009223', 'Disease') :: ['myotonic dystrophy', 'MD']

entities_list: @entity17 :: ('MESH:D003711', 'Disease') :: ['reduction of the MSA', 'reduction of the myelin sheath area']

answer: @entity3918 :: (MESH:D009223,Disease) :: ['myotonic dystrophy']


abstract: @entity1555 ( @entity1555 ) is a progressive disease of striated @entity121 . Respiratory and @entity299 are particularly clinically relevant because they result in the leading causes of @entity204 in @entity1555 @entity1 . Despite the clinical and physiological significance of these systems, little has been done to understand the cardiorespiratory interaction in @entity1555 . We show here that prior to the onset of global @entity299 , @entity942 mdx @entity19 have @entity299 with the right ventricle being particularly affected. Using a novel biventricular cardiac catheterization technique coupled with cardiac stress testing, we demonstrate that both the right and left ventricles have significant reductions in both systolic and diastolic function in response to @entity452 . Unstimulated cardiac function is relatively normal except for a significant reduction in the ventricular pressure transient duration compared with controls. These biventricular analyses also reveal the absence of a @entity452 -induced increase in isovolumic relaxation in the right ventricle of control hearts. Simultaneous assessment of biventricular pressure demonstrates a @entity452 -dependent enhancement of coupling between the ventricles in control @entity19 , which is absent in mdx @entity19 . Furthermore, studies probing the passive-extension properties of the left ventricle demonstrate that the mdx heart is significantly more compliant compared with age-matched C57BL/10 hearts, which have an age-dependent stiffening that is completely absent from @entity299 . These new results indicate that right ventricular @entity82 is an early indicator of the development of @entity296 , suggesting a mechanism by which @entity1576 may accelerate the development of @entity712 in @entity1555 .

title: Early right ventricular @entity82 and reduction in biventricular cardiac reserve in the XXXX mdx heart.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity452 :: ('MESH:D004280', 'Chemical') :: ['dobutamine']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['dystrophic cardiomyopathy']

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity1555 :: ('MESH:D020388', 'Disease') :: ['Duchenne muscular dystrophy', 'DMD']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory insufficiency']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac muscle dysfunction', 'increased cardiac fibrosis', 'dystrophic hearts', 'cardiac dysfunction']

entities_list: @entity121 :: ('MESH:D009135', 'Disease') :: ['muscle deterioration']

entities_list: @entity942 :: ('MESH:D003677', 'Disease') :: ['dystrophin-deficient']

answer: @entity942 :: (MESH:D003677,Disease) :: ['dystrophin-deficient']


abstract: BACKGROUND AND AIM: @entity1 colic is a prevalent physiological event of healthy @entity1 under 3 months of age, which can disrupt the @entity1 's home environment. Despite its benign natural history, sometimes it requires a therapeutic approach. There is limited evidence supporting the use of complementary and alternative treatments. The aim of this study was to investigate the effectiveness of a mixture of standardized extract of matricariae Chamomilla L., Melissa Officinalis L. and tyndallized @entity9206 (H122) compared with @entity6374 (DSM 17938) and with @entity21710 for the treatment of infantile colic. @entity1 AND METHODS: A multicenter prospective, randomized comparative study was conducted involving 133 @entity1 with colic, according to Rome III criteria, who were assigned at random to receive Chamomilla L., Melissa Officinalis L. and tyndallized @entity9206 (H122) (Group A; n=45), @entity6374 DSM 17938 (10 CFU) (Group B; n=45) or @entity21710 (GroupC; n=43). Treatment was given to subjects for 21 days and they were followed for 4 weeks. Treatment success was assessed at the end of study period. Daily crying and fussing times were recorded in a structured diary, and maternal questionnaires were completed to monitor changes in @entity1 colic symptoms and adverse events. RESULTS: Treatment success was observed in 30 out of 45 @entity1 (66.7%) of @entity1 in Group A, while it was seen in 31 out of 45 @entity1 (68.9%) of Group B and in 19 out of 43 (44.2%) of subjects of Group C (  : 6.8; p=0.03). Mean daily crying time was more significantly reduced (from 211.3  40 min/day to 69.6  59 min/day) in the Group A and in Group B (from 201.6  32.5 min/day to 58.1  48.9 min/day) when compared with Group C (from 199.5  32 min/day to 106  56.5 min/day) (p<0.01, p=0.006 respectively). No significant difference was observed comparing Group A and B (p=0.4). No adverse events were reported in any group. CONCLUSIONS: This study suggests that administration of Chamomilla L., Melissa Officinalis L. and tyndallized @entity9206 (H122) and @entity6374 DSM 17938 are significantly more effective than @entity21710 in improving colic symptoms. Therefore, the use of herbal supplements may represent a new therapeutic strategy in the management of colicky @entity1 .

title: PP-12 EFFICACY OF A STANDARDIZED EXTRACT OF MATRICARIAE CHAMOMILLA L., MELISSA OFFICINALIS L. AND TYNDALLIZED @entity9206 (H122) COMPARED WITH @entity6374 (DSM 17938) AND WITH XXXX FOR THE TREATMENT OF INFANTILE COLIC.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Infant', 'patients', 'infant', 'PATIENTS', 'infants', 'child']

entities_list: @entity21710 :: ('MESH:D012841', 'Chemical') :: ['simethicone']

entities_list: @entity9206 :: ('1579', 'Species') :: ['L. Acidophilus', 'Lactobacillus Acidophilus']

entities_list: @entity6374 :: ('1598', 'Species') :: ['Lactobacillus Reuteri', 'L reuteri']

answer: @entity21710 :: (MESH:D012841,Chemical) :: ['SIMETHICONE']


abstract: BACKGROUND: Goblet cell carcinoid is a rare variant of @entity2466 with mixed endocrine and exocrine features. The most common symptom and signs are @entity490 , @entity697 and palpable mass. Additionally, @entity490 is common in @entity1 on peritoneal dialysis, which may confound the diagnosis in such @entity1 . CASE PRESENTATION: We report a 71- years- old @entity1 on peritoneal dialysis that experienced several episodes of abdominal cramping @entity158 . She had one episode of severe @entity158 and underwent an appendectomy for suspicion of @entity698 . Goblet cell carcinoid was diagnosed. She had no further @entity490 after she received appendectomy. CONCLUSIONS: Malignant dialysate was rarely reported in @entity1 with peritoneal dialysis. However, @entity4303 can initially present with @entity697 , chronic intermittent @entity490 and mimicking @entity298 . In systemically reviewing the literature, this is the first case report of @entity298 with peritoneal dialysis caused by @entity4303 .

title: @entity4303 presenting with recurrent @entity298 in a XXXX on peritoneal dialysis: a case report.

entities_list: @entity1 :: ('9606', 'Species') :: ['woman', 'patient']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute appendicitis']

entities_list: @entity698 :: ('MESH:D001064', 'Disease') :: ['appendicitis']

entities_list: @entity2466 :: ('MESH:D001063', 'Disease') :: ['appendiceal carcinoid']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['pain and sterile peritonitis', 'pain']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity4303 :: ('MESH:D002276', 'Disease') :: ['goblet cell carcinoid']

entities_list: @entity298 :: ('MESH:D010538', 'Disease') :: ['sterile peritonitis', 'peritonitis']

answer: @entity1 :: (9606,Species) :: ['patient']


abstract: AIM: To evaluate the neurosensory outcome of management of damaged @entity129 caused by endodontic overfilling and to assess the efficacy of delayed surgical intervention. METHODOLOGY: Nine @entity1 who underwent surgical removal of extruded endodontic material were included. All @entity1 were evaluated for neurosensory function using a set of standardized tests. The outcome of surgical intervention was evaluated through @entity1 interview and quantitative statistical analysis. RESULTS: Surgical procedures included @entity5744 , microsurgical external/internal decompression, excision of @entity2950 followed by nerve repair, and excision of damaged nerve segment with interpositional nerve graft. Seven of the nine @entity1 had significant improvement according to the follow-up neurosensory assessment. Four @entity1 reported significant improvement, three @entity1 reported mild improvement and two @entity1 reported no appreciable improvement in the Visual Analog Scale (VAS). Two @entity1 who reported no appreciable improvement in VAS also did not achieve FSR. In these @entity1 , @entity6086 was spread widely along the IAN and a surgical approach was obtained via sagittal spit osteotomy. The mean time to reach FSR was 222.7 (  41.8)  days with a range of 106-397  days. In the early repair group who received surgery within 60  days, three out of five @entity1 achieved FSR in a mean time of 198.0 (  76.2)  days. The mean time to FSR in all four subjects who received surgical attention over 60  days after injury was 241.3 (  139.8)  days with a range of 106-397  days. As all four cases in the late repair group with limited amount of @entity128 achieved FSR, only 3 of 5 early repair cases with wide-spread injury achieved a similar outcome. CONCLUSION: The results of this case series confirmed the notion that surgical management of the @entity129 is effective in the treatment of @entity128 caused by endodontic extrusion of @entity6086 paste. Delayed surgical repair of the @entity129 can be indicated and helpful for the neurosensory recovery of damaged IAN, however, the surgical management was less effective in case of widespread @entity128 .

title: Surgical management of damaged @entity129 caused by endodontic overfilling of XXXX paste.

entities_list: @entity129 :: ('MESH:D003389', 'Disease') :: ['inferior alveolar nerves', 'inferior alveolar nerve']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity5744 :: ('MESH:D005547', 'Disease') :: ['foreign body removal']

entities_list: @entity128 :: ('MESH:D020209', 'Disease') :: ['nerve injury', 'nerve injuries']

entities_list: @entity6086 :: ('MESH:D002126', 'Chemical') :: ['calcium hydroxide']

answer: @entity6086 :: (MESH:D002126,Chemical) :: ['calcium hydroxide']


abstract: INTRODUCTION: Septal deviation is often found in conjunction with other pathological conditions that adversely affect nasal patency. Anterior septal deviation, together with @entity30744 , is a relatively rare @entity177 . In our experience, it can often be resolved with septoplasty, without the necessity of surgery involving the external valve. The aim of this paper was to verify this hypothesis prospectively. @entity1 AND METHODS: Twelve @entity1 with anterior septal deviation and simultaneous @entity30744 on the opposite side were prospectively enrolled in the study. Subjective assessment of nasal patency was made on post-operative day 1, and again 6 months after surgery, using a subjective evaluation of nasal breathing. The width of the nostril (alar-columellar distance) on the side with the @entity30744 was measured during inspiration pre-operatively, 1 day after surgery and again 6 months after surgery. RESULTS: Immediately after surgery, all @entity1 reported improved or excellent nasal breathing on the side of the original septal deviation. On the collapsed side, one @entity1 reported no change in condition. With the exception of one @entity1 , all measurements showed some degree of improvement in the extension of the alar-columellar distance. The average benefit 6 months after surgery was an improvement of 4.54 mm. CONCLUSION: In our group of @entity1 (anterior septal deviation and simultaneous @entity30744 and no obvious structural changes of the alar cartilage) we found septoplasty to be entirely suitable and we recommend it as the treatment of choice in such cases.

title: Anterior septal deviation and XXXX .

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['type of anatomical and functional incompetence']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity30744 :: ('MESH:C563533', 'Disease') :: ['contralateral alar collapse', 'alar collapse']

answer: @entity30744 :: (MESH:C563533,Disease) :: ['contralateral alar collapse']


abstract: We evaluated the association between chlorination byproducts and @entity694 risk in a population-based case-control study conducted in Iowa in 1986-1989. Data were gathered from 685 @entity694 cases, 655 @entity5 cases, and 2,434 controls. We calculated odds ratios for the 560 @entity694 cases, 537 @entity5 cases, and 1,983 controls for whom water exposure information was available for at least 70% of their lifetime. We estimated exposure to chlorination byproducts with two types of measures: duration of lifetime at residences served by chlorinated water and estimated lifetime @entity26625 exposure. For @entity5 , we observed an association with duration of chlorinated surface water use, with adjusted odds ratios of 1.1, 1.6, 1.6, and 2.6 for 1-19, 20-39, 40-59, and > or =60 years of exposure, compared with no exposure. @entity5 risk was also associated with several different measures of estimated lifetime @entity26625 exposure. For @entity694 and subsites, we detected no important increase in risk associated with duration of chlorinated surface water, nor with @entity26625 estimates. When we evaluated chlorination byproducts jointly with other factors, we found larger relative risk estimates for @entity5 among subjects with low dietary fiber intake. The risk related to > or =40 years of exposure to a chlorinated surface water source was 2.4 (95% confidence interval = 1.5-4.0) for @entity1 with low fiber intake and 0.9 (95% confidence interval = 0.4-1.8) for @entity1 with high fiber intake, relative to the risk of @entity1 with high-fiber diets and no exposure to chlorinated surface water. We observed a similar risk differential for low and high levels of physical activity.

title: Drinking water source and chlorination byproducts. II. Risk of XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['rectal cancer', 'Rectal cancer']

entities_list: @entity26625 :: ('MESH:D022882', 'Chemical') :: ['trihalomethane']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon and rectal cancer', 'colon cancer']

answer: @entity694 :: (MESH:D003110,Disease) :: ['colon and rectal cancers']


abstract: A meta-analysis of SPECT brain imaging in @entity302 was performed to derive the sensitivity and specificity of interictal, postictal or ictal rCBF patterns to identify a @entity410 focus in medically refractory @entity1 . METHODS: Papers were obtained by pooling all published articles identified by two independent literature searches: (a) Dialnet (EMBASE) or Radline by CD-ROM and (b) Current Contents searched manually. Literature inclusion criteria were: (a) @entity1 had a localization-related @entity302 ; (b) more than six @entity1 were reported; and (c) @entity1 had at least an interictal EEG-documented @entity302 . Of 46 papers meeting these criteria, 30 contained extractable data. SPECT results were compared to localization by standard diagnostic evaluation and surgical outcome. Meta-analytic sensitivities for SPECT localization in @entity1 with @entity410 relative to diagnostic evaluation were 0.44 (interictal), 0.75 (postictal) and 0.97 (ictal). Similar results were obtained relative to surgical outcome. False-positive rates were low relative to diagnostic evaluation (7.4% for interictal and 1.5% for postictal studies) and surgical outcome (4.4% for interictal and 0.0% for postictal studies). RESULTS: The results were not dependent on tracer used (or dose), the presence of CT-identified structural abnormalities, blinding of image interpretation or camera quality (although data were more variable with low-resolution cameras). There were insufficient data for conclusions regarding extratemporal- @entity410 or @entity302 . CONCLUSION: Insights gained from reviewing this literature yielded recommendations for minimal information that should be provided in future reports. Additional recommendations regarding the nature and focus of future studies also are provided. The most important of these is that institutions using SPECT imaging in @entity302 should perform ictal, preferably, or postictal scanning in combination with interictal scanning.

title: SPECT brain imaging in XXXX : a meta-analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'temporal lobe seizures']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epileptic syndrome', 'epilepsy', 'pediatric epilepsy populations', 'epileptiform abnormality']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: OBJECTIVE: To investigate the status of @entity1374 among @entity1 aged 14 years and older residing in Huanghua County, an @entity1496 excess intake area in north China. METHODS: 4,230 @entity1 were asked to fulfill the questionnaire and 1,074 among them aged (36.97 +/- 12.83) years were accepted to be samples for the test. All subjects who were taken as samples needed to fill the questionnaire on @entity1374 in detail, accept physical and ultrasound examination. Their morning fasting urine were collected for measurement of @entity6893 concentration, and their sera were measured for thyroid-stimulating hormone(TSH, the third generation), thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb) and thyroglobulin (TG). If some @entity1 had abnormal TSH level, their free T4, free T3 and TSH receptor antibody(TRAb) were measured. RESULTS: The median level of urinary @entity6893 of the sample subjects was 614.61 micrograms/L. The prevalence of clinical and subclinical @entity1378 was 1.21% and 1.12% respectively; 92.3% of the clinical @entity1378 were of Graves' disease and 75% of the subjects with @entity1375 were TRAb positive. The average incidence of clinical @entity1378 was not different between 2 periods before and after general iodinization of table salt in this area (1991-1995 and 1996-2000). The prevalence of clinical and @entity1375 was 1.96% and 6.05% respectively. All the clinical @entity1 were female, among them 85.71% were TPOAb and/or TGAb positive, while only 29.23% of the subclinical @entity1 were TPOAb and/or TGAb positive. Positive TPOAb and TGAb were seen in 11.6% and 9.3% respectively of the sample subjects with an age-related increase. Positive thyroid autoantibody was more common in the female and those with abnormal TSH. The prevalence of @entity259 during the period of 1994-2000 was 91.58/100,000. CONCLUSION: The high prevalence of @entity1375 and @entity259 indicates that excessive @entity1496 intake in this area is not safe.

title: [An epidemiological survey of XXXX in an area with high @entity1496 content in water supply].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['subclinical hypothyroidism', 'hypothyroidism']

entities_list: @entity1378 :: ('MESH:D006980', 'Disease') :: ['hyperthyroidism']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid cancer']

entities_list: @entity1374 :: ('MESH:D013959', 'Disease') :: ['thyroid disorders']

answer: @entity1374 :: (MESH:D013959,Disease) :: ['thyroid disorders']


abstract: The objective of this study was to assess the effect of @entity3303 jelly application to chest tubes on the intensity and duration of @entity158 , chest tube site @entity158 and the required analgesics for @entity282 relief in coronary artery bypass graft (CABG) @entity1 . For @entity1 in group L, we applied sterile 2% @entity3303 jelly on the chest tubes just before insertion, and for @entity1 in group C, we applied normal saline. Overall visual analogue scale (VAS), maximal @entity158 area with their VAS were documented postoperatively, and the frequency that button of @entity1 -controlled analgesia was pressed (FPB) and total @entity3575 consumption were assessed. The number of @entity1 who complained that tube site was the most @entity158 site was significantly higher in group C than in group L (85% vs. 30% at extubation, P<0.001). The overall VAS score was significantly higher in group C than in group L (39.14  12.49 vs. 27.74  13.76 at extubation, P=0.006). After all of the tubes were removed, the VAS score decreased more in group C (5.74  4.77, P<0.001) than in group L (3.05  2.48, P<0.001). FPB and total @entity3575 consumption were significantly higher in group C than in group L (73.00, 59.00-78.00 vs. 34.00, 31.00-39.25, P<0.001; 2,214.65  37.01 vs. 1,720.19  361.63, P<0.001, respectively). @entity3303 jelly application is a very simple way to reduce @entity282 by reducing chest tube site @entity158 after CABG. (Clinical Trials Registry No. ACTRN 12611001215910).

title: Application of XXXX jelly on chest tubes to reduce @entity158 caused by drainage catheter after coronary artery bypass surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['Lidocaine', 'lidocaine']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['overall pain', 'pain', 'painful']

entities_list: @entity282 :: ('MESH:D010149', 'Disease') :: ['postoperative pain']

entities_list: @entity3575 :: ('MESH:D005283', 'Chemical') :: ['fentanyl']

answer: @entity3303 :: (MESH:D008012,Chemical) :: ['lidocaine']


abstract: Computerized axial tomography (CAT) of the abdomen was prospectively compared with peritoneal lavage (PL) in 19 @entity1 who sustained acute blunt @entity1661 . All were selected carefully and were deemed stable, never having been in shock, and all required diagnostic PL. Seven @entity1 underwent exploratory laparotomy on the basis of CAT and PL findings. There were no negative findings at laparotomy. Three significant @entity130 , one @entity99 , and two hemoperitoneums were undetected by CAT. All seven cases explored were preceded by a grossly positive PL. Thus no @entity130 would have been missed if PL had been used alone. There were no complications of PL but one @entity1 aspirated oral contrast medium and one @entity1 developed @entity551 during CAT. Open PL required one half the time (20.6 minutes) as CAT (47.4 minutes). The total cost of CAT was approximately eight times that of PL ( 900.01 versus  116.38). In our hands, PL would seem to be significantly more sensitive with fewer false negative results than CAT of the abdomen in acute blunt @entity1661 , a deviation from results of earlier reported series. CAT alone would have added cost, time, some risk, and very little information of use that would not be obtained by PL followed by surgery. Therefore before CAT replaces PL in the evaluation of adult @entity1 with blunt @entity1661 , we feel that additional prospective studies are needed to better define the accuracy and sensitivity of CAT as compared with PL with regard to intraperitoneal injuries.

title: The use of computerized axial tomography versus peritoneal lavage in the evaluation of blunt XXXX : a prospective study.

entities_list: @entity99 :: ('MESH:D056486', 'Disease') :: ['hepatic laceration']

entities_list: @entity1661 :: ('MESH:D000008', 'Disease') :: ['abdominal trauma']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['splenic injuries', 'major injury']

answer: @entity1661 :: (MESH:D000008,Disease) :: ['abdominal trauma']


abstract: OBJECTIVES: @entity1 with @entity177 are restricted to mild physical activity and tend to a lack of exercise. However, there have been few reports regarding the influence of chronic exercise on the progression of @entity8 . Similarly, there are few animal models concerned with the effect of exercise training on improving renal function. Therefore, we assessed the renal effects of moderate chronic treadmill exercise in a remnant kidney model of spontaneously @entity101 @entity35 (SHR) with @entity177 . We also assessed the effects of exercise and antihypertensive therapy on renal function. DESIGN AND METHODS: Eight-week-old SHR were subjected to 5/6 nephrectomy by removal of the left kidney and excision of two-thirds of the right kidney. The @entity35 were divided into four groups: (i) no exercise (Non-EX); (ii) moderate exercise with treadmill running (20 m/min, 0 grade incline for 60 min) (EX); (iii) EX with an @entity1811 ( @entity1811 ) inhibitor, @entity4688 (2 mg/kg per day, i.p.); and (iv) EX with an angiotensin receptor antagonist, @entity9886 (5 mg/kg per day, i.p.), for 4 weeks. RESULTS: Chronic EX significantly attenuated the increase in @entity644 (P < 0.01) and significantly protected against increases in the @entity8 ( @entity8 ). Both @entity4688 and @entity9886 with EX significantly decreased blood pressure (P < 0.001), and further decreased the @entity8 . In the stepwise multiple regression analysis, only antihypertensive drug remained in the model as a significant predictor of @entity8 (P < 0.0001). In contrast, exercise, antihypertensive drug and mean systolic blood pressure (weeks 1-4) remained in the model as a significant predictors of mean @entity644 (weeks 1-4) (all P < 0.0001). CONCLUSIONS: These results suggest that exercise does not worsen renal function and has renal-protective effects in this model of @entity35 . Moreover, the antihypertensive therapy has additional renal-protective effects in this model of @entity35 .

title: Renal protective effects of chronic exercise and antihypertensive therapy in @entity101 @entity35 with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients']

entities_list: @entity1811 :: ('24310(Tax:10116)', 'Gene') :: ['ACE', 'angiotensin converting enzyme']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['index of glomerular sclerosis', 'renal disease', 'IGS']

entities_list: @entity4688 :: ('MESH:D004656', 'Chemical') :: ['enalapril']

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertensive']

entities_list: @entity9886 :: ('MESH:D019808', 'Chemical') :: ['losartan']

entities_list: @entity177 :: ('MESH:D051437', 'Disease') :: ['chronic renal failure']

answer: @entity177 :: (MESH:D051437,Disease) :: ['chronic renal failure']


abstract: BACKGROUND: The incidence of urinary stone disease has shown a steep rise in recent decades along with marked modifications in dietary habits and life- style. There has been an increased prevalence of urinary stone disease in @entity1 with @entity6 . We took up this study to determine the association of @entity6 with @entity1290 in @entity1 undergoing surgical treatment. MATERIALS AND METHODS: @entity1 presenting with @entity1290 for surgical management formed the study group. Body mass index (BMI) was calculated by noting the weight and height of the @entity1 . The extracted stone/stone fragments were analyzed to determine the chemical composition. Urinary pH was similarly noted in all. RESULTS: The mean BMI among the diabetics was 26.35    5.20 (range 17.75-35.60), whereas the mean BMI among the non-diabetics was 23.41    2.85 (range 17.71-31.62) (P < 0.0004). The incidence of @entity414 calculi in the diabetics was significantly high (P < 0.03). The mean urinary pH among the diabetics was 5.61    0.36 and among the non-diabetics was 6.87    0.32, which was significantly lower (P < 0.000044). CONCLUSIONS: There is a strong association between type 2 @entity6 and @entity414 stone formation. There is also a strong association between @entity6 , BMI, and also with lower urinary pH.

title: XXXX and @entity1290 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['kidney stones', 'renal stones']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes', 'diabetes mellitus']

entities_list: @entity414 :: ('MESH:D014527', 'Chemical') :: ['uric acid']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Type 2 diabetes mellitus']


abstract: UNASSIGNED: Bleeding is a feared complication of invasive procedures in @entity1 with @entity82 and @entity1003 (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets ( @entity49683 ). Thromboelastography (TEG) provides a more @entity1650 assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in @entity1 with @entity82 and @entity1003 (defined in this study as INR >1.8 and/or platelet count <50 * 10(9) /L) who will be undergoing an invasive procedure. Sixty @entity1 were randomly allocated to TEG-guided transfusion strategy or standard of care (SOC; 1:1 TEG:SOC). The TEG group would receive FFP if the reaction time (r) was >40 min and/or @entity49683 if maximum amplitude (MA) was <30 mm. All SOC @entity1 received FFP and/or @entity49683 per hospital guidelines. Endpoints were blood product use and @entity548 complications. Baseline characteristics of the two groups were similar. Per protocol, all subjects in the SOC group received blood product transfusions versus 5 in the TEG group (100% vs. 16.7%; P   <   0.0001). Sixteen SOC (53.3%) received FFP, 10 (33.3%) @entity49683 , and 4 (13.3%) both @entity49683 . In the TEG group, none received FFP alone (P   <   0.0001 vs. SOC), 2 received @entity49683 (6.7%; P   =   0.009 vs. SOC), and 3 both @entity49683 (not significant). Postprocedure @entity548 occurred in only 1 @entity1 (SOC group) after large-volume paracentesis. CONCLUSIONS: In @entity1 with @entity82 and @entity1003 before invasive procedures, TEG-guided transfusion strategy leads to a significantly lower use of blood products compared to SOC (transfusion guided by INR and platelet count), without an increase in @entity548 complications. Remarkably, even in @entity1 with @entity1003 , postprocedure @entity548 was rare, indicating that TEG thresholds should be reevaluated. (Hepatology 2016;63:566-573).

title: Thrombelastography-guided blood product use before invasive procedures in XXXX with severe @entity1003 : A randomized, controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['cirrhosis']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['bleeding']

entities_list: @entity1650 :: ('MESH:D001308', 'Disease') :: ['comprehensive global coagulation']

entities_list: @entity1003 :: ('MESH:D001778', 'Disease') :: ['significant coagulopathy']

answer: @entity82 :: (MESH:D005355,Disease) :: ['cirrhosis']


abstract: PURPOSE: Among @entity1 with multiply relapsed @entity521 refractory to conventional chemotherapy, oral @entity1945 has often been used for palliation. Although @entity137 was generally thought to be mild, the efficacy of such an approach remains unproven. METHODS: The authors retrospectively analyzed @entity1 with multiply relapsed or refractory @entity521 who were treated with oral @entity1945 for palliation. Each course was generally 1 mg/m2/d in two divided doses, for 21 consecutive days, repeated after a 1-week rest in @entity1 without symptoms of @entity74 . Disease status was assessed by radiographic studies, urine @entity2922 levels, and multiple @entity236 and biopsies. RESULTS: Twenty @entity1 between the ages of 3 and 34 (median 13 years) received 1 (n = 7), 2 (n = 3), 3 (n = 4), 4 (n = 2), 6 (n = 2), and 12 courses (n = 2). Prior treatments included multiple cycles of high-dose alkylator-based chemotherapy (n = 20), high-dose intravenous @entity1945 (n = 8), myeloablative chemotherapy or radioimmunotherapy (n = 10), or experimental biologic agents (n = 16). Anti- @entity521 effects were seen in five @entity1 lasting 6 to 12 months; two additional @entity1 remained stable for 4 months. Thirteen @entity1 had @entity74 (11 after one or two cycles). @entity137 included @entity294 (n = 12) requiring a dose adjustment in three @entity1 and discontinuation of the drug in a fourth, and myelosuppression (n = 11) requiring transfusion and/or @entity1261 support. CONCLUSIONS: Oral @entity1945 therapy has antitumor activity in a small percentage of @entity1 with relapsed or refractory @entity521 . @entity137 , including @entity294 and myelosuppression, may necessitate a dose adjustment in this @entity1 population. Low-dose oral @entity1945 may have utility in the treatment of @entity521 .

title: Oral XXXX for refractory and relapsed @entity521 : a retrospective analysis.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'Toxicity', 'Toxicities']

entities_list: @entity1261 :: ('1440', 'Gene') :: ['granulocyte-colony stimulating factor']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['progressive disease']

entities_list: @entity521 :: ('MESH:D009447', 'Disease') :: ['neuroblastoma']

entities_list: @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine']

entities_list: @entity236 :: ('MESH:D001855', 'Disease') :: ['bone marrow aspirations']

entities_list: @entity1945 :: ('MESH:D019772', 'Chemical') :: ['topotecan']

answer: @entity1945 :: (MESH:D019772,Chemical) :: ['topotecan']


abstract: OBJECTIVES: To describe specific aspects of the diagnostic process of transmissible spongiform @entity75 in Spain and to evaluate the 14-3-3 protein test in cerebrospinal fluid. METHODS: The annual pattern of diagnostic certainty as well as those of demand and results of biochemical and genetic studies were studied using two sets of @entity1 , those diagnosed for the 1993-1998 period, notified to a National @entity3605 Register (NCDJR), and those referred to the Tissue Bank for Neurological Research Laboratory (TBNRL). The 14-3-3 protein test was validated taking as a reference two clinical populations. RESULTS: Two-hundred and four @entity3605 cases were registered at the NCDJR: 39 out of them and 28 other @entity1 had been studied at the TBNRL. The proportion of definite @entity3605 cases decreased since 1996. Among those registered in 1997-1998, 35.5%, 36% and 20% had undergone 14-3-3 protein in LCR, histopathologic and genetic studies. The 14-3-3 test grave, for definite, @entity13895 as compared for @entity1 with other @entity74 , the following data: 12/13 sensitivity; 33/35 specificity; and 12/14 and 33/34 predictive values of positive and negative test. Two familial cases were diagnosed by identification of mutations in the TBNRL. CONCLUSIONS: The results suggest that: a) the diagnostic certainty of @entity3605 in Spain decreased due to a drop in autopsy rates; b) the 14-3-3 cerebrospinal fluid test has a high diagnostic value, and its use diffused rapid but incompletely; c) genetic studies are useful in some cases, and d) @entity3605 undereporting may be considerable. @entity3605 diagnosis and surveillance, are closely related and being consolidated in Spain.

title: [Diagnosis of transmissible spongiform XXXX in Spain. Population perspective].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathies']

entities_list: @entity3605 :: ('MESH:D007562', 'Disease') :: ['Creutzfeldt-Jakob disease', 'Creutzfeldt-Jakob Disease']

entities_list: @entity13895 :: ('MESH:C565143', 'Disease') :: ['sporadic Creutzfeldt-Jakob disease']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['dementing disorders']

answer: @entity75 :: (MESH:D001927,Disease) :: ['encephalopathies']


abstract: UNASSIGNED: A central step in the initiation of chromosomal DNA replication in eukaryotes is the assembly of pre-replicative complex (pre-RC) at late M and early G1 phase of the cell cycles. Since 1973, four proteins or protein complexes, including cell division control protein 6 (Cdc6)/Cdc18, minichromosome @entity22 ( @entity22 ), origin recognition complex (ORC), and Cdt1, are known components of the pre-RC. Previously, we reported that a non-ORC protein binds to the essential element delta 9 of the @entity6739 DNA replication origin ARS3001. In this study, we identified that the non-ORC protein is Sap1. Like ORC, Sap1 binds to DNA origins during cell growth cycles. But unlike ORC, which binds to asymmetric AT-rich sequences through its nine AT-hook motifs, Sap1 preferentially binds to a DNA sequence of 5-( @entity2775 )nC/G @entity69196 ( @entity2775 )n-3. We also found that Sap1 and ORC physically interact. We further demonstrated that Sap1 is required for the assembly of the pre-RC because of its essential role in recruiting Cdc18 to DNA origins. Thus, we conclude that Sap1 is a replication-initiation factor that directly participates in the assembly of the pre-RC. DNA replication origins in @entity6739 are defined by possessing two essential elements with one bound by ORC and the other by Sap1.

title: Sap1 is a replication initiation factor essential for the assembly of pre-replicative complex in the XXXX @entity6739 .

entities_list: @entity6739 :: ('4896', 'Species') :: ['Schizosaccharomyces pombe', 'fission yeast']

entities_list: @entity2775 :: ('c|SUB|A||T', 'DNAMutation') :: ['A/T']

entities_list: @entity22 :: ('MESH:D007319', 'Disease') :: ['MCM', 'maintenance protein complex']

answer: @entity6739 :: (4896,Species) :: ['fission yeast']


abstract: Elderly @entity1 with diseases of the central nervous system often show @entity74 . Before these disorders can be called pathological, they must be distinguished from the physiological effects of aging. The purpose of this study was to determine the effect of aging on @entity227 . Ninety healthy volunteers were divided into three groups (younger than 30 years; 30-50 years; older than 50 years), with 30 volunteers in each group. Visual and auditory predictive 15-degree saccades were evoked and recorded with electrooculography. Recorded parameters were peak velocity, duration, and latency. Both stimuli showed increasing latencies with increasing age and a higher peak velocity in the middle group as compared to the oldest group. The latter result was significant only for saccades to visual targets. Duration was almost identical for both patterns and all age groups. Between the age groups, latencies were significantly shorter for the saccades to auditory targets, and no differences in peak velocity occurred. The results stress the importance of an age-related assessment for saccadic parameters. The increasing latency and decreasing peak velocity in elderly @entity1 probably result from age-related @entity179 that are involved in the generation of saccadic eye movements. We found no indications of a different effect of aging through either the visual or the auditory pathway for saccadic parameters.

title: Effect of aging on saccadic eye movements to XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'people']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual and auditory saccadic eye movements']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative changes in central nervous system parts']

entities_list: @entity74 :: ('MESH:D030342', 'Disease') :: ['saccadic disorders']

answer: @entity227 :: (MESH:D014786,Disease) :: ['visual and auditory targets']


abstract: PURPOSE: Geographic access to care may be associated with receipt of chemotherapy but has not been fully examined. This study sought to evaluate the association between density of oncologists and travel distance and receipt of adjuvant chemotherapy for @entity694 within 90 days of colectomy. @entity1 AND METHODS: @entity1 in the National @entity5 Data Base with @entity5 , diagnosed between 2007 and 2010, and age 18 to 80 years were selected. Generalized estimating equation clustering by hospital service area was conducted to examine the association between geographic access and receipt of oncology services, controlling for @entity1 sociodemographic and clinical characteristics. RESULTS: Of 34,694 @entity1 in the study cohort, 75.7% received adjuvant chemotherapy within 90 days of colectomy. Compared with travel distance less than 12.5 miles, @entity1 who traveled 50 to 249 miles (odds ratio [OR], 0.87; P=.009) or >= 250 miles (OR, 0.36; P<.001) had decreased likelihood of receiving adjuvant chemotherapy. Density level of oncologists was not statistically associated with receipt of adjuvant chemotherapy (low v high density: OR, 0.98; P=.77). When stratifying analyses by insurance status, non-privately insured @entity1 who resided in areas with low density of oncologists were less likely to receive adjuvant chemotherapy (OR, 0.85; P=.03). CONCLUSION: Increased travel burden was associated with a decreased likelihood of receiving adjuvant chemotherapy, regardless of insurance status. @entity1 with nonprivate insurance who resided in low-density oncologist areas were less likely to receive adjuvant chemotherapy. If these findings are validated prospectively, interventions to decrease geographic barriers may improve the timeliness and quality of @entity694 treatment.

title: Association Between Geographic Access to XXXX Care, Insurance, and Receipt of Chemotherapy: Geographic Distribution of Oncologists and Travel Distance.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity694 :: ('MESH:D003110', 'Disease') :: ['colon cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['stage III colon cancer', 'Cancer']

answer: @entity5 :: (MESH:D009369,Disease) :: ['Cancer']


abstract: UNASSIGNED: The mechanistic understanding of lifestyle contributions to disease has been largely driven by work in laboratory rodent models using environmental interventions. These interventions show an array of methodologies and sometimes unclear collective conclusions, hampering clinical interpretations. Here we discuss environmental enrichment, exercise and stress interventions to illustrate how different protocols can affect the interpretations of environmental factors in disease. We use @entity2033 ( @entity2033 ) as an example because its @entity19 models exhibit excellent validity and @entity2033 was the first genetic animal model in which environmental stimulation was found to be beneficial. We make a number of observations and recommendations. Firstly, environmental enrichment and @entity2798 generally show benefits across laboratories and @entity19 models. However, the extent to which these environmental interventions have beneficial effects depends on parameters such as the structural complexity of the cage in the case of enrichment, the timing of the intervention and the nature of the control conditions. In particular, clinical interpretations should consider deprived control living conditions and the ethological relevance of the enrichment. Secondly, stress can have negative effects on the phenotype in @entity19 models of @entity2033 and other @entity75 . When modeling stress, the effects of more than one type of experimental stressor should be investigated due to the heterogeneity and complexity of stress responses. With stress in particular, but ideally in all studies, both sexes should be used and the randomized group sizes need to be sufficiently powered to detect any sex effects. Opportunities for clinical translation will be guided by the 'environmental construct validity' of the preclinical data, including the culmination of complementary protocols across multiple animal models. Environmental interventions in @entity19 models of @entity2033 provide illustrative examples of how valid preclinical studies can lead to conclusions relevant to clinical populations.

title: What's wrong with my XXXX cage? Methodological considerations for modeling lifestyle factors and gene-environment interactions in @entity19 .

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['brain disorders']

entities_list: @entity2033 :: ('MESH:D006816', 'Disease') :: ["Huntington's disease", 'HD']

entities_list: @entity2798 :: ('MESH:D009155', 'Disease') :: ['voluntary exercise']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: OBJECTIVE: The aim of this study was to investigate the possible effects of age-related intracranial changes on the potential outcome of @entity21 and acute subdural @entity1410 under rotational head loading. METHODS: A simulation-based parametric study was conducted using an updated and validated finite element model of a @entity35 head. The validation included a comparison of predicted brain cortex sliding with respect to the skull. Further, model material properties were modified to account for aging; predicted tissue strains were compared with experimental data in which groups of @entity35 in 2 different lifecycle stages, young adult and mature adult, were subjected to rotational @entity130 . For the parameter study, 2 age-dependent factors-brain volume and region-specific brain material properties-were implemented into the model. The models young adult and old age were subjected to several injurious and subinjurious sagittal plane rotational acceleration levels. RESULTS: Sequential analysis of the simulated @entity130 progression indicates that an increase in acute subdural @entity130 risk indicator occurs at an early stage of the @entity130 , whereas an increase in @entity21 risk indicators occurs at a later stage. Tissue stiffening from young adult to mature adult @entity35 produced an increase in strain-based thresholds accompanied by a wider spread of strain distribution toward the rear part of the brain, consistent with rotational @entity130 experiments with young adult and mature adult @entity35 . Young adult to old age brain tissue softening and @entity1010 resulted in an increase in @entity21 and acute subdural @entity130 risk indicators, respectively. CONCLUSIONS: The findings presented in this study suggest that age-specific injury thresholds should be developed to enable the development of superior restraint systems for the elderly. The findings also motivate other further studies on age-dependency of @entity542 .

title: Effect of aging on brain injury prediction in rotational XXXX -a parameter study with a @entity35 finite element model.

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head trauma']

entities_list: @entity1010 :: ('MESH:C566985', 'Disease') :: ['brain atrophy']

entities_list: @entity21 :: ('MESH:D001480', 'Disease') :: ['diffuse axonal injuries', 'diffuse axonal injury']

entities_list: @entity130 :: ('MESH:D014947', 'Disease') :: ['hematoma injury', 'trauma']

answer: @entity542 :: (MESH:D006259,Disease) :: ['head trauma']


abstract: BACKGROUND: @entity68965 is a K-cell derived gut peptide with insulin-releasing activity which is rapidly degraded following release into the circulation. We hypothesized that substitution of all naturally-occurring Lys and @entity534 residues with @entity7647 would lead to prolonged enzyme resistance and enhanced biological efficacy. METHODS: Peptide stability was assessed using @entity19 plasma, in vitro insulin-releasing actions evaluated in BRIN-BD11 cells and acute @entity413 -lowering and insulin-releasing actions examined in high fat fed @entity19 . For sub-chronic studies, a range of metabolic parameters and pancreatic histology were assessed in high fat fed @entity19 which had received saline vehicle or @entity68965 ( @entity7647 ) twice-daily for 21days. RESULTS: In contrast to native @entity68965 , @entity68965 ( @entity7647 ) was resistant to plasma-mediated degradation and significantly stimulated insulin secretion in BRIN-BD11 cells. Acute administration of @entity68965 ( @entity7647 ) in high fat fed @entity19 significantly reduced blood @entity413 and increased plasma insulin concentrations. Twice-daily administration of @entity68965 ( @entity7647 ) in high fat fed @entity19 did not affect food intake, body weight or circulating insulin concentrations but significantly decreased blood @entity413 from day 9 onwards. Furthermore, @entity413 tolerance, @entity413 -mediated insulin secretion, insulin sensitivity and GIP-stimulated insulin-release were significantly enhanced in @entity68965 ( @entity7647 )-treated @entity19 . Pancreatic immunohistochemistry revealed decreased alpha cell area with increased beta cell area and beta-to-alpha cell ratio in @entity68965 ( @entity7647 )-treated @entity19 . In addition, @entity68965 ( @entity7647 ) exerted similar beneficial actions in ob/ob @entity19 as demonstrated by reduced blood @entity413 , superior glycaemic response and @entity413 -mediated insulin release. CONCLUSIONS: @entity68965 ( @entity7647 ) is resistant to plasma-mediated degradation and exerts sustained and beneficial metabolic actions in high fat fed and ob/ob @entity19 . GENERAL SIGNIFICANCE: @entity3264 ( @entity7647 )-modified analogues of xenin may represent an attractive therapeutic approach for type 2 @entity6 .

title: A novel chemically modified analogue of XXXX exhibits improved @entity413 -lowering and insulin-releasing properties.

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity68965 :: (MESH:C077659,Chemical) :: ['xenin-25']


abstract: We have reported that increased @entity2227 concentrations in microdialysate of the cerebrospinal fluid (CSF) may be clue phenomena to elucidate mechanisms of @entity2359 of intrathecal @entity6513 . However, little is known about whether this is true for other local anesthetics. In this study, we compared the effects of local anesthetics on @entity2227 concentrations in CSF microdialysate and neurologic and histopathologic outcome. @entity95 were assigned into 5 groups (n = 6 in each) and intrathecally received 0.3 mL of @entity1219 solution (control), 2% @entity6513 , 10% @entity3303 , 2% @entity1341 , or 2% @entity1342 . Neurologic and histopathologic assessments were performed 1 wk after the administration. Intrathecal local anesthetics significantly increased @entity2227 concentrations with no significant differences among the four local anesthetics. The sensory and motor functions in the @entity3303 group were significantly worse than in the other groups. Characteristic histopathologic changes were vacuolation in the dorsal funiculus and chromatolytic damage of motor neurons. The extent of vacuolation of the dorsal funiculus was in the order of @entity3303 = @entity6513 > @entity1341 > @entity1342 . Although the differences among the local anesthetics cannot be explained by @entity2227 concentrations, the results suggest that the margin of safety may be smallest with @entity3303 . IMPLICATIONS: Large concentrations of local anesthetics administered intrathecally increased @entity2227 concentrations in the cerebrospinal fluid. The margin of safety may be smallest with @entity3303 .

title: A comparison of the @entity2359 effects on the spinal cord of @entity6513 , @entity3303 , @entity1341 , and @entity1342 administered intrathecally in XXXX .

entities_list: @entity2227 :: ('CHEBI:29987', 'Chemical') :: ['glutamate']

entities_list: @entity1342 :: ('MESH:C037663', 'Chemical') :: ['ropivacaine']

entities_list: @entity1341 :: ('MESH:D002045', 'Chemical') :: ['bupivacaine']

entities_list: @entity6513 :: ('MESH:D013748', 'Chemical') :: ['tetracaine']

entities_list: @entity3303 :: ('MESH:D008012', 'Chemical') :: ['lidocaine']

entities_list: @entity2359 :: ('MESH:D020258', 'Disease') :: ['neurotoxicity']

answer: @entity95 :: (9986,Species) :: ['rabbits']


abstract: A @entity1 aged 6 years presented with genital precocity, enlarged testes and advanced linear growth. An ovoid mass 3-4 cm in diameter was identified by MRI scan in the right adrenal gland. Serum concentrations of LH, @entity251 , alpha-subnuit, @entity2990 , @entity2671 and @entity53 were persistently elevated. LH was unresponsive to bolus i.v. injection of @entity1176 or to @entity1176 analogue therapy. Serum FSH was normal. After removal of the @entity5 , serum LH, alpha-subunit, @entity251 and adrenal @entity342 levels fell to normal. In incubation medium of cultured disaggregated @entity5 cells, LH concentrations were greater than twice the mean serum concentration and 4-5-fold higher than in the medium of cultured non-neoplastic adrenal cells. Specific immunostaining of the @entity5 was positive for LH and alpha-subunit in many areas and these were not found in the adjacent non-neoplastic adrenal. Testicular biopsy showed almost complete spermatogenesis although germinal cell types were numerically lower than in normal @entity1 . These findings are consistent with an @entity822 secreting LH being the cause of the @entity1 's precocious puberty.

title: Luteinizing hormone secreting XXXX as a cause of precocious puberty.

entities_list: @entity251 :: ('MESH:D013739', 'Chemical') :: ['testosterone']

entities_list: @entity2990 :: ('CHEBI:16814', 'Chemical') :: ['dehydroepiandrosterone sulphate']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['adrenal tumour', 'tumour']

entities_list: @entity53 :: ('MESH:D004958', 'Chemical') :: ['oestradiol']

entities_list: @entity342 :: ('CHEBI:50113', 'Chemical') :: ['androgen']

entities_list: @entity822 :: ('MESH:D018246', 'Disease') :: ['adrenocortical adenoma']

entities_list: @entity2671 :: ('MESH:D000735', 'Chemical') :: ['androstenedione']

answer: @entity5 :: (MESH:D009369,Disease) :: ['adrenal tumour']


abstract: OBJECTIVES: The purpose of this investigation was to determine the prevalence of sound, decayed, filled, and sealed permanent tooth surfaces for @entity1 and adolescents from three fluoridated communities in British Columbia and to develop a predictive model of sealant use that included the @entity1547 status of tooth surfaces. METHODS: @entity1 in grades 2 and 3 (n = 2,715) and adolescents in grades 8 and 9 (3,317) were surveyed to determine the prevalence of sound, decayed, filled, and sealed permanent tooth surfaces. The DMFS index, modified to include incipient (D1) and cavitated (D2) lesions, was used to measure the status of all tooth surfaces. The prevalence of D1D2MF and sealed tooth surfaces was estimated by age group and tooth type. @entity2357 models were developed to analyze the association between a number of independent variables and sealant use. RESULTS: About 60 percent of surveyed students had one or more sealants present, with a mean of 3.2 sealants per subject. Of all pit and fissure surfaces on permanent first molars, 23.4 percent and 20.1 percent were sealed for the 11 years and younger and 12 years and older age groups, respectively. For these same two age groups, the percentages of pit and fissure surfaces that were decayed and filled were 6.7 percent and 19.7 percent, respectively. For both age groups combined, 10.8 percent and 23.7 percent of all pit and fissure surfaces on second molars and premolars, respectively, were sealed. The prevalence of decayed and filled pit and fissure surfaces was 5.6 percent and 1.8 percent, respectively, for second molars and premolars. Premolars were being sealed at a rate of 13 to 1 compared to the number of decayed and filled surfaces. @entity2357 failed to identify meaningful predictors of sealant use. CONCLUSIONS: Results from this study found an increase in the prevalence of sealants in the three communities surveyed, yet failed to identify criteria used by dentists or auxiliaries when making decisions about sealant placement. Professional education in the appropriate use of sealants may be necessary.

title: The relationship between the number of sound, decayed, and filled permanent tooth surfaces and the number of sealed surfaces in XXXX and adolescents.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Children']

entities_list: @entity1547 :: ('MESH:D003731', 'Disease') :: ['dental caries']

entities_list: @entity2357 :: ('MESH:C537770', 'Disease') :: ['Logistic regression']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: INTRODUCTION: Delayed @entity2806 (DCI) after @entity510 ( @entity510 ) can be reversible or progress to @entity385 . In @entity1 with a deterioration clinically diagnosed as DCI, we investigated whether CT perfusion (CTP) can distinguish between reversible @entity63 and @entity63 progressing to @entity385 . METHODS: From a prospectively collected series of @entity510 @entity1 , we included those with DCI, CTP on the day of clinical deterioration, and follow-up imaging. In qualitative CTP analyses (visual assessment), we calculated positive and negative predictive value ( @entity2286 and NPV) with 95  % confidence intervals (95%CI) of a perfusion deficit for @entity1188 on follow-up imaging. In quantitative analyses, we compared perfusion values of the least perfused brain tissue between @entity1 with and without @entity1188 by using receiver-operator characteristic curves and calculated a threshold value with @entity2286 and NPV for the perfusion parameter with the highest area under the curve. RESULTS: In qualitative analyses of 33 included @entity1 , 15 of 17 @entity1 (88  %) with and 6 of 16 @entity1 (38  %) without @entity1188 on follow-up imaging had a perfusion deficit during clinical deterioration (p   =   0.002). Presence of a perfusion deficit had a @entity2286 of 71  % (95%CI: 48-89  %) and NPV of 83  % (95%CI: 52-98  %) for @entity1188 on follow-up. Quantitative analyses showed that an absolute minimal cerebral blood flow (CBF) threshold of 17.7  mL/100  g/min had a @entity2286 of 63  % (95%CI: 41-81  %) and a NPV of 78  % (95%CI: 40-97  %) for @entity1188 . CONCLUSIONS: CTP may differ between @entity1 with DCI who develop @entity1188 and those who do not. For this purpose, qualitative evaluation may perform marginally better than quantitative evaluation.

title: CT perfusion during delayed @entity2806 after XXXX : distinction between reversible @entity63 and @entity63 progressing to @entity1188 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity510 :: ('MESH:D013345', 'Disease') :: ['aneurysmal subarachnoid hemorrhage', 'aSAH']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarction']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity510 :: (MESH:D013345,Disease) :: ['subarachnoid hemorrhage']


abstract: OBJECTIVES: To investigate the impact of preprocedural left ventricular (LV) diastolic function on outcomes of @entity1 with postprocedural @entity337 (ARpost ) following @entity886 ( @entity886 ). BACKGROUND: The predictors and mechanisms of the increased mortality in @entity1 with ARpost are inadequately defined. METHODS: Baseline clinical and echocardiographic variables from a prospective @entity886 registry were analyzed. Preprocedural correlates of late outcomes (all-cause mortality and the composite of mortality, @entity64 , @entity712 , and new-onset @entity955 ) were examined according to the presence and severity of ARpost . RESULTS: Of the 418 @entity1 undergoing @entity886 , ARpost was present in 212 (51%): mild 36%, moderate-severe 15%. Mean follow-up was 909        489 days. All-cause mortality and composite endpoint rates were significantly increased in @entity1 with moderate-severe ARpost compared with @entity1 with either none or only mild ARpost (38, 22, 21%, P   =   0.02; and, 56, 35, 40%, P   =   0.01; respectively). Moderate-severe (though not mild) ARpost was independently associated with mortality and the composite endpoint (HR   =   1.93 [95%CI 1.15-3.14], P   =   0.01; HR   =   1.85 [95%CI 1.22-2.77], P   =   0.004], respectively). By multivariate analysis, preprocedural LV deceleration time (DT)   <   160 ms was independently associated with the risk of all-cause mortality and the composite endpoint among @entity1 with mild @entity1984 (HR   =   1.74 [95%CI 1.14-2.60], P   =   0.01; and, HR   =   1.73 [95%CI 1.23-2.41], P   =   0.002, respectively) and moderate-severe ARpost (HR   =   1.81 [95%CI 1.28-2.51], P   <   0.001; HR   =   1.86 [95%CI 0.22-2.80], P   =   0.004, respectively). CONCLUSIONS: Preprocedural impairment of @entity1002 , reflected by short DT, portends an adverse prognosis in @entity886 @entity1 who develop ARpost independently of other clinical and echocardiocardigraphic measures including AS severity and systolic LV function.    2015 Wiley Periodicals, Inc.

title: @entity337 following XXXX : Impact of preprocedural left ventricular diastolic filling patterns on late clinical outcomes.

entities_list: @entity712 :: ('MESH:D006333', 'Disease') :: ['heart failure']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['transcatheter aortic valve replacement', 'TAVR']

entities_list: @entity337 :: ('MESH:D001022', 'Disease') :: ['aortic regurgitation']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial fibrillation']

entities_list: @entity1002 :: ('MESH:D018487', 'Disease') :: ['LV filling']

answer: @entity886 :: (MESH:C563178,Disease) :: ['transcatheter aortic valve replacement']


abstract: Using endogenous lipid substrates, assays of lipid phosphorylation indicated that neuronal nuclei had a considerable superiority in @entity8558 (PA) formation when compared with homogenates and other subfractions of cerebral cortex. This predominance of neuronal nuclear PA labelling was linked to a sizable pool of nuclear @entity13286 that expanded significantly with incubation. PA was also the dominant product of neuronal nuclear lipid phosphorylation reactions. Nuclear envelope preparations and the parent neuronal nuclei showed specific rates of PA formation that were comparable, based upon membrane phospholipid contents. As well, using an exogenous @entity2366 substrate, the distribution of @entity2366 kinase activities closely followed phospholipid contents of subfractions derived from the neuronal nucleus during envelope preparation. This evidence suggested an association between @entity2366 kinase and the neuronal nuclear envelope. Nuclear PA formation increased in the presence of @entity5597 , while @entity5597 decreased PA formation in other subfractions. Likely @entity5597 exerted its effect on nuclear @entity2366 kinase, as @entity5597 did not elevate levels of nuclear @entity13286 . @entity7985 was present in the nuclei and inhibitors of this enzyme did decrease PA formation, indicating @entity13286 from inositides as substrates for nuclear @entity2366 kinase. The nuclear envelope fraction had a considerably lower specific @entity7985 activity than the parent nuclei, and showed an activation of PA formation by @entity5597 , but a less efficient handling of the exogenous @entity2366 substrate. It is possible that @entity7985 and @entity2366 kinase are closely situated within the neuronal nuclei, and a loss of the former activity may compromise the latter.

title: XXXX is the prominent product of endogenous neuronal nuclear lipid phosphorylation, an activity enhanced by @entity5597 , linked to phospholipase C and associated with the nuclear envelope.

entities_list: @entity2366 :: ('CHEBI:41847', 'Chemical') :: ['diacylglycerol']

entities_list: @entity8558 :: ('MESH:D010712', 'Chemical') :: ['phosphatidic acid']

entities_list: @entity7985 :: ('5335', 'Gene') :: ['phosphoinositidase C', 'Phosphoinositidase C']

entities_list: @entity5597 :: ('MESH:D013110', 'Chemical') :: ['sphingosine']

entities_list: @entity13286 :: ('MESH:D004075', 'Chemical') :: ['diacylglycerols']

answer: @entity8558 :: (MESH:D010712,Chemical) :: ['Phosphatidic acid']


abstract: UNASSIGNED: This study aimed to review the clinical features and outcome of 53 @entity1 with @entity6872 managed at our Institution between 1976 and 2012. Thirty-five @entity1 had @entity79 and 18 extramedullary @entity6872 . @entity5 sizes were larger in @entity1 with bone involvement (P  =  0  003). Treatment consisted of local radiotherapy (n  =  26), radiotherapy  +  chemotherapy (n  =  15), surgery (n  =  4) and chemotherapy (n  =  8); the local control rate was 94  3%. Progression to multiple @entity1582 was recorded in 20/35 (57  1%) @entity1 with bone involvement and in 1/18 (5  5%) @entity1 with extramedullary disease (P  =  0  0003). The 5-year @entity1349 ( @entity1349 ) rate was 78  4%; @entity79 @entity1 had a significantly worse @entity1349 (71  9% vs. 88  2%, respectively; P  =  0  029) and 5-year progression-free survival (PFS; 53  0% vs. 88  5%; P  =  0  0003) compared to extramedullary @entity6872 @entity1 . On univariate analysis, @entity79 and size (>= 5  cm) impacted negatively on PFS (P  =  0  0027 and P  =  0  04, respectively). @entity79 also affected @entity1349 (P  =  0  04). In multivariate analysis bone location was the only independent prognostic factor for PFS (P  =  0  0041) and @entity1349 (P  =  0  021). @entity1 with @entity79 have a significantly worse prognosis than extramedullary @entity6872 cases.

title: Clinical features and prognostic factors in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity6872 :: ('MESH:D010954', 'Disease') :: ['solitary plasmacytoma']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Tumour']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['Bone disease', 'bone disease', 'bone solitary plasmacytoma']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity6872 :: (MESH:D010954,Disease) :: ['solitary plasmacytoma']


abstract: PURPOSE: To determine the clinical efficacy of diffusion-weighted and perfusion echo-planar magnetic resonance (MR) imaging in the evaluation of @entity7025 . MATERIALS AND METHODS: Seventeen @entity1 with @entity7025 were examined prospectively with diffusion-weighted and perfusion echo-planar MR imaging and conventional angiography. The change in the effective transverse relaxation rate (delta R2*) peak value, delta R2* peak time, and delta R2* integral were calculated to assess regional cerebral perfusion. The MR images were compared with angiographic images. RESULTS: Of the 34 posterior cerebral arteries (PCAs) of the 17 @entity1 , 14 PCAs (41%) in 11 @entity1 showed @entity850 or @entity432 . The delta R2* peak value ratio in the cerebral hemispheres decreased significantly, and the delta R2* peak time ratio increased significantly, with @entity5546 and @entity432 . However, no correlation was apparent between perfusion and extent of the stenotic or occlusive lesions of the internal carotid artery bifurcation. The frequency of @entity385 was significantly increased in @entity1 with stenotic or occlusive @entity75 . For three acute @entity1188 , a decrease in the apparent diffusion coefficient was significantly correlated with a decrease in the delta R2* peak value, an increase in the delta R2* peak time, and a decrease in the delta R2* integral. CONCLUSION: Regional cerebral perfusion in @entity7025 is decreased and delayed with @entity5546 , with greater decrease and delay with @entity432 . Diffusion-weighted and perfusion imaging are useful for evaluating @entity2806 in @entity7025 .

title: XXXX : evaluation with diffusion-weighted and perfusion echo-planar MR imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['PCA lesions']

entities_list: @entity5546 :: ('MESH:C562643', 'Disease') :: ['PCA stenosis']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarctions']

entities_list: @entity7025 :: ('MESH:D009072', 'Disease') :: ['moyamoya disease']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['PCA occlusion', 'occlusion']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarctions']

answer: @entity7025 :: (MESH:D009072,Disease) :: ['Moyamoya disease']


abstract: James' adaptation of the Glasgow @entity772 scale (JGCS) was designed for young @entity1 . Intubated @entity1 are not allocated a verbal score, however, so important changes in a @entity1 's conscious level may be missed. A grimace score was therefore developed and assessed for use in intubated @entity1 . Two observers made a JGCS observation within 15 minutes of each other. One observer was the @entity1 's nurse and the other a trained investigator. Interobserver reliability was determined between the first and second observation for each component of the scale. Reliability was measured using kappa and weighted kappa statistics. Seventy three @entity1 had 104 sets of observations. Interobserver reliability was moderate to good for all components, with the grimace score better than the verbal score. It is concluded that the grimace score is more reliable than the verbal score and may be useful in intubated @entity1 in whom the verbal score cannot be used.

title: Development of a modified paediatric XXXX scale in intensive care clinical practice.

entities_list: @entity1 :: ('9606', 'Species') :: ['patient', 'children', 'patients']

answer: @entity772 :: (MESH:D003128,Disease) :: ['coma']


abstract: BACKGROUND: In 2002, an increased risk of @entity2650 was reported for sons of @entity1 exposed to @entity4742 ( @entity4743 ) in utero, suggesting transgenerational effects of @entity4743 . The aim of this study was to further assess the association between parental @entity4743 exposure and @entity2650 in a case-referent study. METHODS: Cases with @entity2650 were retrieved from the hospital information system. Referents were recruited via the parents of cases. Both parents completed postal questionnaires. Associations were estimated by odds ratios (OR) with 95% confidence intervals (CI). Additionally, conditional logistic regression analyses were performed for a matched subset of parents. RESULTS: The final database included 583 cases and 251 referents. In the initial analyses, an indication was found for an increased risk of @entity2650 when mothers were exposed to @entity4743 in utero: OR=2.3 (95% CI 0.7-7.9). Conditional logistic regression resulted in a stronger risk estimate: OR=4.9 (95% CI 1.1-22.3). Paternal exposure to @entity4743 did not increase the risk. CONCLUSIONS: The results confirm an increased risk of @entity2650 when mothers were exposed to @entity4743 in utero. However, the excess risk appears to be of much smaller magnitude than in the 2002 study. Further research on the potential health risks for the third generation is of great importance.

title: @entity2650 : a transgenerational effect of XXXX ?

entities_list: @entity4742 :: ('MESH:D004054', 'Chemical') :: ['diethylstilbestrol']

entities_list: @entity2650 :: ('MESH:D007021', 'Disease') :: ['hypospadias']

answer: @entity4742 :: (MESH:D004054,Chemical) :: ['diethylstilbestrol']


abstract: The intestinal protozoan @entity461 is a widespread opportunistic parasite of @entity1 and animals. This parasite inhabits the upper part of the small intestine and has a direct life cycle. After ingestion of cysts, which are the infective stage, the trophozoites emerge from the cysts in the duodenum and attach to the small intestinal mucosa of the host. Since the migration of trophozoites from the lumen of the intestine into surrounding tissues is an unusual occurrence, the immune response to Giardia remains localized. The identification of antigens that play a role in acquired immunity has been difficult because of the occurrence of antigenic variation and because, Giardia being an ubiquitous organism, it is possible that the antigenic profiles of isolates from different geographic areas will vary. Innate-immunity mechanisms play a role in the control and/or severity of the @entity281 . Both humoral and cell-mediated immune responses play a role in acquired immunity, but the mechanisms involved are unknown. A variety of serological assays have been used to detect circulating antibodies in serum. Because of the biological characteristics of the parasite and the lack of suitable antigens, the sensitivity of serological assays remains poor. On the other hand, detection of antigens in feces of infected @entity1 has met with success. Commercial kits are available, and they are reported to be more sensitive than microscopic examination for the detection of @entity7014 on a single specimen.

title: Immune response to XXXX .

entities_list: @entity461 :: ('5741', 'Species') :: ['Giardia duodenalis']

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'patients']

entities_list: @entity7014 :: ('MESH:D005873', 'Disease') :: ['giardiasis']

entities_list: @entity281 :: ('MESH:D007239', 'Disease') :: ['infection']

answer: @entity461 :: (5741,Species) :: ['Giardia duodenalis']


abstract: Anti-nucleosome antibodies have a role in the diagnosis and follow-up of @entity1252 ( @entity1252 ) and have a possible correlation with @entity1252 activity and with kidney and hematological involvement. The aim of our study was to detect in 91 @entity1 with @entity309 ( @entity309 ) the positivity of anti-nucleosome antibodies during therapy with three different @entity310 blocking agents and to underline the possible correlation with the development of antinuclear autoantibodies (ANA) and anti-dsDNA autoantibodies. We detected anti-nucleosome antibodies, ANA, and anti-dsDNA during therapy with three different @entity310 blocking agents at T-0 and after 12 and 24 weeks of treatment, respectively. Anti-nucleosome antibodies (IgG class) were analyzed by ELISA technique (Orgentec Diagnostika GmbH, Mainz, Germany), ANA both by indirect immunofluorescence (IIF) technique on Hep-2 (Scimedx, USA) and by ELISA (Autoimmune EIA ANA screening test Bio-Rad Laboratories, CA, USA), and anti-dsDNA (IgG and IgM classes) by ELISA (Kallestad, Bio-Rad Laboratories, CA, USA) and confirmed by IIF on Crithidia luciliae (ImmunoConcepts N.A., Sacramento, CA, USA). We observed 19 @entity1 on infliximab treatment at 3 mg/kg every 8 weeks, 43 @entity1 on etanercept treatment at 25 mg twice a week, and 29 @entity1 on adalimumab treatment at 40 mg every other week. At baseline, we observed positivity as follow: in the group of @entity1 treated with infliximab-anti-nucleosome 1/19 (5.26%), ANA 3/19 (15.7%), anti-dsDNA 1/19 (5.26%); in the group treated with etanercept--anti-nucleosome 2/43 (4.65%), ANA 1/43 (2.43%), anti-dsDNA 0/43; and in the group treated with adalimumab--anti-nucleosome 2/29 (6.89%), ANA 1/29 (3.44%), anti-dsDNA 0/29. The results at 12 weeks for the three autoantibodies were: for infliximab--3/19 (15.7%), 10/19 (52.6%), 2/19 (10.5%); for etanercept--3/43 (6.9%), 10/43 (23.2%), 1/43 (2.32%); and for adalimumab--3/29 (10.3%), 4/29 (13.7%), 1/29 (3.4%). At 24 weeks, the results were for infliximab 6/19 (31.5%), 12/19 (63.1%), 2/19 (10.5%); for etanercept 11/43 (25.5%), 22/43 (51.1%), 2/43 (4.65%); and for adalimumab 4/29 (13.7%), 13/29 (44.8%), 1/29 (3.4%). We observed a concordance anti-nucleosome/ANA antibodies of 85.5% (p < 0.001). Our data showed a concordance between anti-nucleosome antibodies and ANA positivity in @entity1 with @entity309 during therapy with @entity310 blocking agents. The induction of autoantibodies positivity is different for each @entity310 blocking agent.

title: Anti-nucleosome antibodies as prediction factor of development of autoantibodies during therapy with three different @entity310 blocking agents in XXXX .

entities_list: @entity1252 :: ('MESH:D008180', 'Disease') :: ['SLE', 'systemic lupus erythematosus']

entities_list: @entity309 :: ('MESH:D001172', 'Disease') :: ['rheumatoid arthritis', 'RA']

answer: @entity309 :: (MESH:D001172,Disease) :: ['rheumatoid arthritis']


abstract: BACKGROUND: In @entity1053 ( @entity1053 ), conventional lifestyle modification measures such as dietary counseling and exercise are supplemented with relaxation techniques and psychological motivational elements. This review studied the effect of @entity1053 on @entity299 and mortality in @entity1 with @entity301 ( @entity301 ). METHODS: This review is based on publications up to and including January 2015 that were retrieved by a systematic search in PubMed, the Cochrane Library, and Scopus. Randomized controlled trials of the effect of @entity1053 programs (versus standard treatment) on @entity299 , overall mortality, and/or cardiac mortality were analyzed. @entity731 , blood pressure, LDL @entity165 , and the body mass index (BMI) were chosen as secondary outcomes. Random-effects meta-analyses were performed. The risk of bias was assessed with the Cochrane tool. RESULTS: Twelve trials, performed on a total of 1085 @entity1 , were included in the analysis. Significant differences between groups were found with respect to @entity299 (odds ratio [OR]: 0.38; 95% confidence interval [CI]: 0.23-0.61; p<0.01; heterogeneity [I2]: 0%), but not overall mortality (OR: 0.82; 95% CI: 0.46-1.45; p = 0.49; I2: 0%) or cardiac mortality (OR: 0.98; 95% CI: 0.43-2.25; p = 0.97; I2: 0%). Significant differences between groups were also found with respect to @entity731 (mean difference [MD] = -7.86% diameter @entity850 ; 95% CI: -15.06-[-0.65]; p = 0.03; I2: 0%) and systolic blood pressure (MD = -3.33 mm Hg; 95% CI: -5.76-[-0.91]; p<0.01; I2: 0%), but not with respect to diastolic blood pressure, LDL @entity165 , or BMI. CONCLUSION: In @entity1 with @entity301 , @entity1053 programs can lessen the occurrence of @entity299 , reduce @entity731 , and lower systolic blood pressure, but they do not reduce mortality. They can be used as a complement to conventional rehabilitation programs.

title: Mind-Body Medicine in the Secondary Prevention of XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['CHD', 'coronary heart disease']

entities_list: @entity1053 :: ('MESH:D001835', 'Disease') :: ['mind-body medicine', 'MBM']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac events']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis', 'Atherosclerosis']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity301 :: (MESH:D003327,Disease) :: ['Coronary Heart Disease']