abstract: OBJECTIVES: To estimate the incidence of surgical complications and associated in-hospital morbidity and mortality following surgery for malignant @entity1313 . @entity1 AND METHODS: The Nationwide Inpatient Sample (NIS) database was queried from 2002 to 2011. All adult @entity1 who underwent elective brain surgery for a @entity1313 were included. @entity532 included wrong side surgery, retention of a foreign object, @entity64 , @entity693 , @entity548 / @entity1410 complicating a procedure, and @entity16 . A regression model was conducted to estimate the odds ratios (OR) with their 95% confidence intervals (95% CI) of in-hospital mortality for each surgical complication. RESULTS: A total of 16,530 admissions were analyzed, with 601 (36.2 events per 1000 cases) surgical complications occurring in 567 @entity1 . Over the examined 10-year period, the overall incidence of surgical complications did not change (P=0.061) except for @entity64 , which increased in incidence from 14.1 to 19.8 events per 1000 between 2002 and 2011 (P=0.023). @entity1 who developed a surgical complication had significantly longer lengths of stay, total hospital costs, and higher rates of other complications. @entity1 who experienced an @entity64 had a significantly increased risk of mortality (OR 9.6; 95% 6.3-14.8) and so were @entity1 with a @entity548 / @entity1410 (OR 3.3; 95% CI 1.6-6.6). CONCLUSION: In this study of an administrative database, @entity1 undergoing surgery for a @entity1313 who suffered from a surgical complication had significantly longer lengths of stay, total hospital charges, and complication rates. Having a surgical complication was also an independent risk factor for in-hospital mortality. Nonetheless, it is unclear whether all surgical complications were clinically relevant, and further research is encouraged.

title: @entity532 following XXXX surgery: An analysis of 2002-2011 data.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PATIENTS']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['iatrogenic strokes', 'iatrogenic stroke']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['malignant brain tumor', 'brain tumors']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological complications']

entities_list: @entity532 :: ('MESH:D003925', 'Disease') :: ['Surgical complications']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['meningitis']

answer: @entity1313 :: (MESH:D001932,Disease) :: ['malignant brain tumor']


abstract: PURPOSE: Although segmentectomy is attempted for small @entity1149 ( @entity1149 ) @entity5 , no reports have so far described how many of these @entity5 can be candidates for a successful resection by single segmentectomy. METHODS: In all, 135 @entity1 with peripheral p-T1N0M0 @entity1149 were examined. The @entity5 were classified into five groups divided by every 0.5-cm increase in size. @entity5 locations were classified into two groups - limited to within one segment and extended beyond one segment - based on the identification of whether pulmonary vessels and the bronchi were involved in the @entity5 on high-resolution computed tomography. Differences in the proportion of @entity5 limited within one segment between @entity5 smaller and larger than each class of @entity5 size were assessed. RESULTS: The @entity5 sizes were 0-1.0 cm in 8 @entity5 , 1.1-1.5 cm in 27, 1.6-2.0 cm in 35, 2.1-2.5 cm in 34, and 2.6-3.0 cm in 31 @entity5 . Of these 135 @entity5 , 92 (65%) were limited to one segment, whereas 48 (35%) had extended beyond one segment. When the @entity5 size was less than 30 mm, the proportion of @entity5 limited within one segment did not show any significant difference depending on the size of the @entity5 . CONCLUSIONS: More than one-third of p-T1N0M0 @entity1149 extended beyond one segment, irrespective of size. It is therefore noteworthy that resection of up to two segments or lobectomy should be undertaken for prevention of local recurrence in @entity1 with p-T1N0M0 peripheral @entity1149 .

title: How many pathological T1N0M0 XXXX can be completely resected in one segment? Special reference to high-resolution computed tomography findings.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'Tumor', 'tumors']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer', 'NSCLC tumors']

answer: @entity1149 :: (MESH:D002289,Disease) :: ['non-small cell lung cancers']


abstract: Young, healthy outpatients (100) undergoing restorative dentistry and/or oral surgery under enfluranenitrous @entity8369 - @entity26 anaesthesia were given 0.014 mg/kg of @entity6918 or a saline placebo i.v. in a double-blind random fashion 5 min after induction of anaesthesia to prevent @entity1209 . Overall, less @entity1 given @entity6918 were nauseated (18%) or vomited (7%) in comparison with @entity1 given saline (27% and 11%, respectively). During the first postoperative hour, 4% of @entity1 given @entity6918 were nauseated and 2% vomited, whereas 16% of @entity1 given saline were nauseated and 6% vomited. Four @entity1 given saline were not discharged from the clinic 1 h after anaesthesia owing to prolonged @entity390 and @entity391 . The time elapsed until the @entity1 were oriented as to time and place after cessation of @entity4488 and @entity3810 administration was similar in both groups (mean +/- s.d., 13.5 +/- 4.7 min). Thirty minutes after anaesthesia, the ability to walk on a straight line was significantly (P less than 0.001) worse in @entity1 given @entity6918 as compared to @entity1 given saline. After 60 min, only one @entity1 given @entity6918 and four @entity1 who received saline and vomited took side steps or were unable to walk. Psychomotor performance was significantly (P less than 0.05) better in a perceptual speed test both 30 and 60 min after anaesthesia in @entity1 receiving saline as compared to those given @entity6918 . It is concluded that although @entity6918 is a less effective antiemetic after outpatient than after inpatient enflurane anaesthesia, small doses of @entity6918 may be used for outpatients prone to @entity391 to prevent delayed discharge from the clinic due to prolonged @entity391 .

title: Effect of a small dose of @entity6918 on XXXX , @entity391 and recovery after outpatient enflurane anaesthesia.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity6918 :: ('MESH:D004329', 'Chemical') :: ['droperidol']

entities_list: @entity3810 :: ('MESH:D009609', 'Chemical') :: ['nitrous oxide']

entities_list: @entity4488 :: ('MESH:D004737', 'Chemical') :: ['enflurane']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['postoperative nausea and vomiting']

answer: @entity390 :: (MESH:D009325,Disease) :: ['nausea']


abstract: UNASSIGNED: Colistin and @entity6414 are effective treatment options for Gram-negative resistant bacteria but are used as last-line therapy due to their dose-limiting nephrotoxicity. A critical factor in developing safer polymyxin analogues is understanding accumulation of the drugs and their metabolites, which is currently limited due to the lack of effective techniques for analysis of these challenging molecules. @entity2996 ( @entity2996 ) allows direct detection of targets (drugs, metabolites, and endogenous compounds) from tissue sections. The presented study exemplifies the utility of @entity2996 by measuring the distribution of @entity69934 , colistin, and @entity6414 nonapeptide ( @entity69935 ) within dosed @entity35 kidney tissue sections. The label-free @entity2996 analysis revealed that the nephrotoxic compounds (polymyxin B1 and @entity3273 ) preferentially accumulated in the renal cortical region. The less nephrotoxic analogue, @entity69935 , was more uniformly distributed throughout the kidney. In addition, metabolites of the dosed compounds were detected by @entity2996 . Kidney homogenates were analyzed using LC/MS/MS to determine total drug exposure and for metabolite identification. To our knowledge, this is the first time such techniques have been utilized to measure the distribution of @entity3272 drugs and their metabolites. By simultaneously detecting the distribution of drug and drug metabolites, @entity2996 offers a powerful alternative to tissue homogenization analysis and label or antibody-based imaging.

title: Investigating Nephrotoxicity of XXXX Derivatives by Mapping Renal Distribution Using Mass Spectrometry Imaging.

entities_list: @entity3273 :: ('MESH:D003091', 'Chemical') :: ['colistin']

entities_list: @entity69935 :: ('MESH:C038934', 'Chemical') :: ['polymyxin B nonapeptide', 'PMBN']

entities_list: @entity6414 :: ('MESH:D011112', 'Chemical') :: ['polymyxin B']

entities_list: @entity3272 :: ('MESH:D011113', 'Chemical') :: ['polymyxin']

entities_list: @entity2996 :: ('MESH:C564543', 'Disease') :: ['Mass spectrometry imaging', 'MSI']

entities_list: @entity69934 :: ('MESH:C121746', 'Chemical') :: ['polymyxin B1']

answer: @entity3272 :: (MESH:D011113,Chemical) :: ['Polymyxin']


abstract: Complex III (CIII; ubiquinol @entity4674 reductase of the mitochondrial respiratory chain) catalyzes electron transfer from @entity4588 and @entity2125 -linked dehydrogenases to @entity4674 . CIII is made up of 11 subunits, of which all but one ( @entity13508 ) are encoded by nuclear DNA. @entity6345 are rare and manifest heterogeneous clinical presentations. Although pathogenic mutations in the gene encoding mitochondrial @entity13508 have been described, mutations in the nuclear-DNA-encoded subunits have not been reported. Involvement of various genes has been indicated in assembly of @entity375 CIII (refs. 8-11). So far only one such gene, @entity35506 , has been identified in @entity1 . @entity35506 represents, therefore, an obvious candidate gene in @entity6345 . Here, we report @entity35506 mutations in six @entity1 , from four unrelated families and presenting neonatal proximal @entity8 , hepatic involvement and @entity75 . Complementation study in @entity375 confirmed the deleterious effect of these mutations. Mutation of @entity35506 would seem to be a frequent cause of @entity6345 , as one-third of our @entity1 have @entity35506 mutations.

title: A mutant mitochondrial respiratory chain assembly protein causes @entity6345 in @entity1 with @entity8 , XXXX and liver failure.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity2125 :: ('MESH:D009243', 'Chemical') :: ['nicotinamide adenine dinucleotide']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['tubulopathy']

entities_list: @entity4588 :: ('MESH:D019802', 'Chemical') :: ['succinate']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['encephalopathy']

entities_list: @entity6345 :: ('MESH:C565128', 'Disease') :: ['CIII deficiencies', 'CIII deficiency']

answer: @entity75 :: (MESH:D001927,Disease) :: ['encephalopathy']


abstract: BACKGROUND: Medication is the mainstay of treatment for @entity161 or @entity161 -like illnesses. Many @entity1 , however, continue to experience symptoms in spite of medication. In addition to medication, creative therapies, such as art therapy may be helpful. Art therapy allows exploration of the @entity1 's inner world in a non-threatening way through a therapeutic relationship and the use of art materials. It was mainly developed in adult @entity146 inpatient units and was designed for use with @entity1 in whom verbal psychotherapy would be impossible. OBJECTIVES: To review the effects of art therapy as an adjunctive treatment for @entity161 compared with standard care and other psychosocial interventions. SEARCH STRATEGY: We searched the Cochrane @entity161 Group's Register (May 2002), hand searched reference lists and 'Inscape' (the Journal of the British Association of Art Therapists), and contacted relevant authors. SELECTION CRITERIA: All randomised controlled trials that compared art therapy with standard care or other psychosocial interventions for @entity161 . DATA COLLECTION AND ANALYSIS: Studies were reliably selected, quality assessed and data extracted. Data were excluded where more than 50% of @entity1 in any group were lost to follow up. For binary outcomes we calculated a fixed effects risk ratio (RR) and its 95% confidence interval (CI). MAIN RESULTS: The search identified 57 reports but only two studies (total n=137) met the inclusion criteria. Both compared art therapy plus standard care with standard care alone. Fewer @entity1 allocated to art therapy left the study before 20 weeks compared with those given standard care alone (n=47, 1 RCT, RR 0.34 CI 0.15 to 0.8, NNT 3 CI 1.5 to 7). Measures of change in mental state, interpersonal relationships and social networking were reported but the data were too problematic to interpret with confidence. Much data was lost due to poor reporting or inappropriate use of scales. REVIEWER'S CONCLUSIONS: Randomised studies have been proven to be possible in this field. The use of art therapy for serious mental illnesses should continue to be under evaluation as its benefits, or harms, are unclear.

title: Art therapy for XXXX or @entity161 -like illnesses.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patient', 'people']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia', 'Schizophrenia']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric']

answer: @entity161 :: (MESH:D012559,Disease) :: ['schizophrenia']


abstract: BACKGROUND/AIMS: To examine the reproducibility of lesion dimensions of the @entity989 ( @entity989 ) in neovascular @entity1020 ( @entity1020 ) with polarisation-sensitive optical coherence tomography (PS- @entity6653 ), specifically imaging the @entity989 . METHODS: Twenty-six @entity1 (28 eyes) with @entity1020 were included in this study, and examined by a PS- @entity6653 prototype. Each @entity1 was scanned five times at a 1-day visit. The PS- @entity6653 B-scan located closest to the macular centre presenting with @entity989 @entity194 was identified, and the longitudinal diameter of the lesion was quantified manually using AutoCAD 2008. This procedure was followed for the identical B-scan position in all five scans per eye and @entity1 . Reproducibility of qualitative changes in PS- @entity6653 was evaluated. Interobserver variability was assessed. Results were compared with intensity-based spectral-domain @entity6653 (SD- @entity6653 ) imaging. RESULTS: Mean variability of all @entity194 lesion dimensions was 0.10   mm (SD  =0.06   mm). Coefficient of variation (SD  /mean) was 0.06 on average (SD  =0.03). Interobserver variability assessment showed a mean difference of 0.02   mm across all @entity1 regarding @entity989 lesion size evaluation (paired t test: p=0.38). Spearman correlation coefficient was r=0.98, p<0.001. Results revealed a good overall reproducibility of    90%. PS- @entity6653 specifically detected the @entity989 in all eyes compared with conventional intensity-based SD- @entity6653 that was not capable to clearly identify @entity989 @entity194 in 25 eyes (89.3%, p<0.01). CONCLUSIONS: PS- @entity6653 offers good reproducibility of @entity989 @entity194 assessment in @entity1020 , and may be suitable for precise @entity989 evaluation in clinical practice. PS- @entity6653 unambiguously identifies @entity989 changes in @entity3193 compared with intensity-based SD- @entity6653 that does not identify the @entity989 status reliably.

title: Polarisation-sensitive XXXX is useful for evaluating retinal pigment epithelial lesions in @entity1 with @entity1020 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity3193 :: ('MESH:D015862', 'Disease') :: ['choroidal neovascularisation']

entities_list: @entity989 :: ('MESH:D012164', 'Disease') :: ['retinal pigment epithelium', 'RPE']

entities_list: @entity1020 :: ('MESH:D008268', 'Disease') :: ['neovascular AMD', 'AMD', 'age-related macular degeneration']

answer: @entity6653 :: (5362,Gene) :: ['OCT']


abstract: BACKGROUND: Oxidative stress and @entity7499 are important elements in the pathogenesis of inflammatory diseases and @entity5 . Our aim was to evaluate the role of both and of antioxidant capacity in the @entity420 sequence in @entity355 . METHODS: In mucosal specimens from 59 @entity1 grouped as having symptomatic @entity354 , @entity355 , or @entity420 in the esophagus, plus controls, we measured @entity3335 activity, superoxidase dismutase activity, @entity2041 content, and total aromatic DNA adducts. To evaluate blood vessel densities and angioarchitecture, we used immunohistochemistry and a modified whole-mount technique. Sections were stained with endothelium-specific markers and smooth muscle cell actin. RESULTS: The @entity189 sequence revealed progressively increased oxidative stress (increased @entity3335 activity), decreased antioxidant capacity ( @entity2041 content), and simultaneous formation of DNA adducts. Pooled data show a negative correlation between @entity2041 content and DNA adducts (-0.28; P =.05). This sequence was also characterized by increased intensity in microvessels and an increasing percentage of immature blood vessels. In addition, the whole-mount technique offered 3-dimensional evidence that the rich new vascular bed is highly abnormal, with repeated twists, bends, or turns, even in nonmalignant Barrett esophagus. CONCLUSIONS: Increased oxidative stress, decreased antioxidant capacity, and a negative correlation between @entity2041 content and DNA adduct formation indicate a link between oxidative stress and @entity355 . Simultaneously, this transformation acquires angiogenic capacity, strong neovascularization, and abnormal angioarchitecture.

title: Simultaneous progression of oxidative stress and @entity7499 in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3335 :: ('4353', 'Gene') :: ['myeloperoxidase']

entities_list: @entity7499 :: ('MESH:D016510', 'Disease') :: ['angiogenesis']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ['Barrett epithelium', 'malignant transformation of Barrett epithelium']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity2041 :: ('MESH:D005978', 'Chemical') :: ['glutathione']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['reflux disease-metaplasia-carcinoma']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux disease']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['metaplasia-dysplasia-adenocarcinoma', 'adenocarcinoma']

answer: @entity5 :: (MESH:D009369,Disease) :: ['malignant transformation of Barrett esophagus']


abstract: BACKGROUND: Phase-contrast magnetic resonance imaging (PC-MRI) enables quantification of cerebrospinal fluid (CSF) flow and total cerebral blood (tCBF) flow and may be of value for the etiological diagnosis of @entity179 . This investigation aimed to study CSF flow and intracerebral vascular flow in @entity1 with @entity195 ( @entity195 ) and @entity1 with @entity73 ( @entity73 ) and to compare the results with @entity1 with @entity5083 ( @entity5083 ) and with healthy elderly volunteers ( @entity4973 ). METHODS: Ten @entity73 and 9 mild @entity195 @entity1 were identified in a comprehensive neurological and neuropsychological assessment. They underwent brain MRI; PC-MRI pulse sequence was performed with the following parameters: two views per segment; @entity1182 angle: 25   for vascular flow and 20   for CSF flow; field-of-view (FOV): 14   14 mm  ; matrix: 256   128; slice thickness: 5 mm; with one excitation for exams on the 3 T machine, and 2 excitations for the 1.5 T machine exams. Velocity (encoding) sensitization was set to 80 cm/s for the vessels at the cervical level, 10 or 20 cm/s for the aqueduct and 5 cm/s for the cervical subarachnoid space (SAS). Dynamic flow images were analyzed with in-house processing software. The @entity1 ' results were compared with those obtained for HEVs (n = 12), and for @entity5083 @entity1 (n = 13), using multivariate analysis. RESULTS: Arterial tCBF and the calculated pulsatility index were significantly greater in @entity73 @entity1 than in HEVs. In contrast, vascular parameters were lower in @entity5083 @entity1 . Cervical CSF flow analysis yielded similar values for all four populations. Aqueductal CSF @entity64 volumes (in  l per cardiac cycle) were similar in HEVs (34    17) and @entity195 @entity1 (39    18). In contrast, the aqueductal CSF was hyperdynamic in @entity73 @entity1 (73    33) and even more so in @entity5083 @entity1 (167    89). CONCLUSION: Our preliminary data show that @entity73 @entity1 present with high systolic arterial peak flows, which are associated with higher mean total cerebral arterial flows. @entity8468 are within normal range in @entity195 and higher than normal in @entity5083 . This study provides an original dynamic vision of cerebral @entity179 , consistent with the vascular theory for @entity195 , and supporting primary flow disturbances different from those observed in @entity5083 .

title: Cerebrospinal fluid and blood flow in mild @entity73 and @entity195 : a differential diagnosis from XXXX .

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['a-MCI', 'amnesic mild cognitive impairment']

entities_list: @entity8468 :: ('OMIM:600791', 'Disease') :: ['Aqueductal CSF oscillations']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['neurodegenerative diseases']

entities_list: @entity195 :: ('MESH:D000544', 'Disease') :: ['AD', "Alzheimer's disease"]

entities_list: @entity5083 :: ('MESH:D006850', 'Disease') :: ['idiopathic normal pressure hydrocephalus', 'NPH']

answer: @entity5083 :: (MESH:D006850,Disease) :: ['idiopathic normal pressure hydrocephalus']


abstract: PURPOSE: The aim of the study was to evaluate the feasibility and efficacy of the combination of @entity2664 , @entity3118 , @entity2592 , and @entity900 (MIFAP) in @entity1 with prognostically unfavorable recurrent and @entity978 ( @entity978 ) and @entity1893 ( @entity1893 ). METHODS: Forty-six @entity1 (median age 43 years, range 18-63) with relapsed (n = 15) or refractory (n = 31) @entity706 were enrolled ( @entity978 , n = 13; low-grade/transformed @entity1893 , n = 4; high-grade @entity1893 , n = 29). A total of 39 @entity1 (85%) showed multiply @entity66 with a duration of prior remission of < 12 months (n = 8) or had @entity706 being resistant to prior chemotherapy (n = 31). The MIFAP therapy consisted of @entity3118 (15 mg/m2, q. 12 h, day 1-4), @entity2592 (50 mg/m2 by continuous infusion (CI) over 22 h, day 1-4), @entity900 (25 or 30 mg/m2 by CI over 24 h, day 1-4), and @entity2664 (4 mg/m2, day 2-5). RESULTS: Thirteen @entity1 (28%) achieved complete remission (CR) and 15 @entity1 (33%) partial remission (PR), for an overall response (OR) rate of 61%. Twenty-two @entity1 responding to MIFAP (10 CR, 12 PR) have been consolidated by high-dose therapy (HDT) with hematopoietic @entity8 ( @entity8 ). After a median follow-up of 12 months, 16 @entity1 are in continuous CR (CCR) (n = 14) or CCRu (unconfirmed) (n = 2). The median duration of event-free survival (EFS) and @entity1349 ( @entity1349 ) were 6.5 and 19.3 months, respectively. Probabilities of EFS and @entity1349 after 3 years were 19% and 40%. Responders consolidated by subsequent HDT showed rates for 3-year EFS and @entity1349 of 40% and 66%, respectively. Unfavorable prognostic factors for EFS by univariate analysis were @entity706 and the presence of @entity1109 . Significant prognostic factors for @entity1349 were @entity1893 , @entity706 , @entity1109 , and bone marrow involvement. The major @entity137 were @entity1431 and @entity882 of the World Health Organization (WHO) grade IV in nearly all courses (median duration 10 and 11 days). In contrast, non-hematological side effects were moderate, predominantly of WHO grades I and II. Treatment-related mortality with MIFAP was 4% (two @entity1 with @entity295 by @entity54 ). CONCLUSIONS: MIFAP is an effective salvage protocol for @entity1 with poor-risk recurrent or refractory @entity978 and @entity1893 . The observed @entity137 seems to be acceptable considering the unfavorable prognosis and intensive pretreatment. The results in @entity1 responding to MIFAP and afterwards undergoing HDT with autologous stem cell support are even comparable to those published in @entity1 with prognostically more @entity66 .

title: Salvage chemotherapy with @entity2664 , @entity3118 , XXXX , and @entity900 (MIFAP) in relapsing and @entity706 .

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['SCT', 'stem cell transplantation']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicities', 'toxicity']

entities_list: @entity295 :: ('MESH:D018805', 'Disease') :: ['septicemia']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['favorable diseases', 'relapsed diseases']

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma', 'refractory lymphoma', 'malignant lymphoma']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity2664 :: ('MESH:D008942', 'Chemical') :: ['mitoxantrone']

entities_list: @entity2592 :: ('MESH:D003561', 'Chemical') :: ['cytarabine']

entities_list: @entity3118 :: ('MESH:C024352', 'Chemical') :: ['fludarabine']

entities_list: @entity54 :: ('746128', 'Species') :: ['Aspergillus fumigatus']

entities_list: @entity1431 :: ('MESH:D007970', 'Disease') :: ['leukocytopenia']

entities_list: @entity1893 :: ('MESH:D008228', 'Disease') :: ["non-Hodgkin's lymphoma", 'NHL']

entities_list: @entity978 :: ('MESH:D006689', 'Disease') :: ['HD', "refractory Hodgkin's disease"]

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity2592 :: (MESH:D003561,Chemical) :: ['cytarabine']


abstract: BACKGROUND: Victims of abusive @entity542 have poor outcomes compared to other injured @entity1 . There is often a delay in diagnosis as these young @entity1 are unable to communicate with healthcare providers. These critically injured @entity1 would benefit from early identification and therapy. METHODS: We performed a retrospective review of our single hospital @entity130 registry from 2005-2014. All level 1 pediatric (age 0-17) @entity130 @entity1 who sustained abusive @entity542 were included. Exclusion criteria included: no admission coagulation studies, prehospital product transfusion, preexisting @entity3459 or @entity204 upon arrival. Primary outcome was mortality; secondary outcomes were early blood transfusion and neurosurgical intervention.Univariate analysis included Fisher exact and Wilcoxon rank-sum testing; we then performed logistic regression modeling and calculated adjusted odds ratios (AOR) to control for known predictors of poor outcome including @entity551 , @entity2332 , @entity520 , @entity2992 , and Head AIS. RESULTS: In 101 total subjects, 35% (n=35) had INR>= 1.3 on admission. On univariate analysis, @entity1 with @entity3459 were more likely to have @entity2332 , @entity551 , @entity520 , high @entity2992 and low GCS (all p<0.05). There was no difference in age, @entity417 , and incidence of @entity1230 . Overall mortality was 24.8% (n=25) which varied significantly based on admission INR (60% INR>= 1.3 vs 6% INR>1.3, p<0.001). @entity1 with elevated INR were also more likely to have early PRBC transfusion (p=0.003) and neurosurgical intervention (p=0.011). In logistic regression analysis, admission INR was the strongest independent predictor of mortality with increased odds of 3.65 (p=0.045). Adjusted odds ratio after controlling specifically for @entity551 , @entity2332 and @entity520 was 6.25 (p=0.006) and after controlling for head AIS and admission GCS the AOR=5.27 (p=0.007). CONCLUSIONS: Admission INR>= 1.3 strongly predicts mortality in abusive @entity542 . These @entity1 should be targeted for early aggressive interventions and monitoring with the goal of improving @entity1 outcomes. Further study is warranted to investigate potential therapeutic targets in @entity130 -induced @entity3459 . LEVEL OF EVIDENCE: III, prognostic and epidemiological.

title: Elevated admission INR strongly predicts mortality in victims of abusive XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

entities_list: @entity542 :: ('MESH:D006259', 'Disease') :: ['head trauma']

entities_list: @entity3459 :: ('MESH:D025861', 'Disease') :: ['coagulation disorder', 'coagulation dysregulation']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity520 :: ('MESH:D000138', 'Disease') :: ['acidosis']

entities_list: @entity1230 :: ('MESH:D009104', 'Disease') :: ['polytrauma']

answer: @entity542 :: (MESH:D006259,Disease) :: ['head trauma']


abstract: OBJECTIVE: To analyze the success rates and prognosis of heart valvuloplasty and valve replacement for elderly @entity1 , and to provide clinical evidence. METHODS: A total of 1240 @entity1 who received heart valve surgeries in our hospital from June 2004 to October 2014 were selected and retrospectively analyzed. They were divided into two groups based on age (60), and those older than 60 (Group B) suffered from @entity340 and nonrheumatic @entity340 including @entity179 . Mitral valve replacement (MVR), tricuspid valve replacement (TVR), @entity886 ( @entity886 ), double valve replacement (DVR), @entity339 ( @entity339 ) and tricuspid valvuloplasty (TVP) were performed by using bioprosthetic and mechanical valves. Before surgery, coronary angiography, coronary artery bypass grafting (CABG), left @entity955 , left atrial wall folding and radiofrequency ablation were conducted. For the @entity1 younger than 60 (Group A) who had @entity299 , @entity340 and @entity340 , MVR, @entity886 , DVR, @entity339 , TVP and closed cuspid commissurotomy were performed with bioprosthetic and mechanical valves. The two groups were then monitored. RESULTS: The mortality rates of Group A and Group B were 2.7% (16 cases) and 3.1% (20 cases) respectively. They died mainly of malignant @entity943 , @entity881 , left @entity9009 , @entity998 , @entity810 , @entity1576 , upper @entity360 , mechanical valve failure and cerebrovascular accident. The two groups had significantly different application rates of bioprosthetic valve, times of auxiliary ventilation and hospitalization stay lengths (P<0.05), but left ventricular ejection fractions, left ventricular end-diastolic diameters (LVEDDs), mortality rates as well as times of aortic cross-clamping and cardiopulmonary bypass were similar (P>0.05). LVEDD, complicated @entity453 , CABG and grade of the New York Heart Association Functional Classification were independent risk factors for @entity204 . CONCLUSION: When heart valvuloplasty and valve replacement were performed for elderly @entity1 , the success rate and prognosis could only be improved by optimizing preoperative preparation, shortening the times of cardiopulmonary bypass and aortic cross-clamping, and paying particular attention to myocardial protection and postoperative treatment.

title: Success rates and prognosis of heart valvuloplasty and valve replacement performed for elderly XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity339 :: ('MESH:D008944', 'Disease') :: ['MVP', 'mitral valvuloplasty']

entities_list: @entity9009 :: ('MESH:D018658', 'Disease') :: ['ventricular rupture']

entities_list: @entity998 :: ('MESH:D002303', 'Disease') :: ['low cardiac output syndrome']

entities_list: @entity886 :: ('MESH:C563178', 'Disease') :: ['AVR', 'aortic valve replacement']

entities_list: @entity881 :: ('MESH:D009102', 'Disease') :: ['multiple organ failure']

entities_list: @entity179 :: ('MESH:D019636', 'Disease') :: ['degenerative valve disease']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['respiratory failure']

entities_list: @entity955 :: ('MESH:D001281', 'Disease') :: ['atrial thrombectomy']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['congenital heart disease']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity453 :: ('MESH:D003324', 'Disease') :: ['coronary artery disease']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['rheumatic valvular heart disease', 'valvular heart disease']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['ventricular arrhythmias']

entities_list: @entity360 :: ('MESH:D006471', 'Disease') :: ['gastrointestinal bleeding']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['postoperative death']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: Global research knowledge has accumulated over the past few decades, and there is reasonable evidence for a positive association between @entity3069 spp. @entity3068 and @entity30 in @entity1 , although its role as a @entity1 pathogen has not been entirely accepted. For this reason, management of public health risk due to M.  @entity3068 remains an important policy issue in agri-food public health arenas in many countries. Responsible authorities must decide whether existing mitigation strategies are sufficient to prevent or reduce @entity1 exposure to M.  @entity3068 . A Web-based questionnaire was administered to topic specialists to elicit empirical knowledge and opinion on the overall public health impact of M.  @entity3068 , the importance of various routes of @entity1 exposure to the pathogen, existing mitigation strategies and the need for future strategies. The questionnaire had four sections and consisted of 20 closed and five open questions. Topic specialists believed that M.  @entity3068 is likely a risk to @entity1 health (44.8%) and, given the paucity of available evidence, most frequently ranked it as a moderate public health issue (40.1%). A significant correlation was detected between topic specialists' commitment to M.  @entity3068 in terms of the number of years or proportion of work dedicated to this topic, and the likelihood of an extreme answer (high or low) to the above questions. Topic specialists identified contact with ruminants and dairy products as the most likely routes of exposure for @entity1 . There was consensus on exposure routes for ruminants and what commodities to target in mitigation efforts. Described mandatory programmes mainly focused on culling diseased animals and voluntary on-farm prevention programmes. Despite ongoing difficulties in the identification of @entity4092 in animals, the topic specialists largely agreed that further enhancement of on-farm programmes in affected commodities by the agri-food industry (68.4%) and allocation of resources by governments to monitor the issue (92%) are most appropriate given the current state of evidence.

title: The potential Public Health Impact of XXXX ssp. @entity3068 : Global Opinion Survey of Topic Specialists.

entities_list: @entity1 :: ('9606', 'Species') :: ['humans', 'human']

entities_list: @entity30 :: ('MESH:D003424', 'Disease') :: ["Crohn's disease"]

entities_list: @entity3069 :: ('1764', 'Species') :: ['Mycobacterium avium']

entities_list: @entity3068 :: ('MESH:D010283', 'Disease') :: ['paratuberculosis']

entities_list: @entity4092 :: ('MESH:D058345', 'Disease') :: ['subclinical infections']

answer: @entity3069 :: (1764,Species) :: ['Mycobacterium avium']


abstract: @entity3323 is formed during cooking processes and is present in many foods. Accumulating evidence suggests that @entity5066 is carcinogenic, but the underlying mechanism remains unclear. Here, we investigated the carcinogenesis mechanisms of @entity5066 . @entity5066 increased the @entity10178 expression. Two major transcription factors, AP-1 and NF-kB, were activated by @entity5066 treatment. @entity5066 induced the ERK phosphorylation, and this was abolished by the treatment of @entity5732 , a pharmacological inhibitor of @entity13438 , an upstream kinase of ERK. @entity5066 -induced expression and promoter activity of @entity10178 were suppressed by @entity5732 . @entity5732 treatment attenuated @entity5066 -induced transactivation of AP-1 and NF-kB, suggesting that the @entity13438 /ERK signaling pathway regulates @entity10178 expression. In addition, @entity3091 , a natural inhibitor of the @entity13438 /ERK signal pathway, reduced @entity5066 -induced activation of the @entity10178 promoter as well as activation of AP-1 and NF-kB. Collectively, these results suggest that the ability of @entity5066 to up-regulate @entity10178 expression through the @entity13438 /ERK signaling pathway underlies @entity5066 .

title: XXXX up-regulates cyclooxygenase-2 expression through the @entity13438 /ERK signaling pathway in mouse epidermal cells.

entities_list: @entity3091 :: ('MESH:C040015', 'Chemical') :: ['myricetin']

entities_list: @entity5066 :: ('MESH:C566236', 'Disease') :: ['AA', 'AA carcinogenicity']

entities_list: @entity3323 :: ('MESH:D020106', 'Chemical') :: ['Acrylamide']

answer: @entity3323 :: (MESH:D020106,Chemical) :: ['Acrylamide']


abstract: BACKGROUND: We measured the functional and metabolic status of hearts submitted to normothermic @entity63 before preservation through the use of an ex  vivo @entity1707 heart model to assess the feasibility of donation after @entity204 ( @entity6061 ) in heart transplantation. METHODS: Ten @entity1707 were separated into 2 groups: control (n  = 6, @entity1620 group) and @entity6061 (n  = 4, heart donation after @entity204 ). In the control group, hearts were excised 20 minutes after the brachiocephalic trunk cross-clamping and were immediately reperfused. In @entity6061 , hearts were excised 20 minutes after exsanguination and @entity1763 , stored in the Centre de R  sonance Magn  tique Biologique et M  dicale (CRMBM) solution for 2 hours, and then were reperfused. @entity1167 was induced with the use of 1 L of CRMBM solution (4  C) and the heart was reperfused for 60 minutes through the use of an ex  vivo perfusion system in Langendorff mode with normothermic autologous blood. During reperfusion, functional parameters were analyzed. Biochemical assays were performed in myocardial effluents and freeze-clamped hearts. RESULTS: No electromechanical activity was found in @entity6061 compared with control. @entity908 kinase (CK) was higher at 2 minutes of reperfusion in @entity6061 versus control (P  = .005). @entity855 was lower in @entity6061 versus control (P  = .0019). @entity1234 , an oxidative stress index, was present only in @entity6061 . The @entity842 (NO) pathway was impaired in @entity6061 versus control, with lower eNOS expression (P  < .0001) and total @entity1507 concentration content (P  = .04). CONCLUSIONS: We reported no cardiac functional and metabolic recovery in the @entity6061 group after normothermic @entity63 and reperfusion, which indicates that a single immersion of the cardiac graft during storage does not provide an optimal protection. New strategies in heart preservation are necessary for recruiting heart donation after @entity204 .

title: Heart donation after @entity204 : preliminary study on an isolated, perfused XXXX heart after 20 minutes of normothermic @entity63 .

entities_list: @entity63 :: ('MESH:D007511', 'Disease') :: ['ischemia']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['Creatine']

entities_list: @entity1507 :: ('CHEBI:48107', 'Chemical') :: ['nitrate']

entities_list: @entity1234 :: ('MESH:D008315', 'Chemical') :: ['Malondialdehyde']

entities_list: @entity842 :: ('MESH:D009569', 'Chemical') :: ['nitric oxide']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['Cardioplegic arrest']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['cardiac death']

entities_list: @entity855 :: ('MESH:D000255', 'Chemical') :: ['Adenosine triphosphate']

answer: @entity1707 :: (9823,Species) :: ['Swine']


abstract: AIMS:     The aim of this study was to investigate and compare effective parameters for gastric electrical stimulation (GES) to modulate gastric muscle functions in different species. METHODS:     Four species: @entity1707 , @entity235 , @entity35 , and @entity19 implanted with two pairs of electrodes on the serosal surface of the stomach were studied, respectively. Experiment 1 was designed to entrain/pace gastric slow waves and included a series of 5-min periods with long-pulse GES of different pulse widths and frequencies. Experiment 2 was designed to induce @entity943 with long-pulse GES of different frequencies. Gastric slow waves were recorded during the entire experiment. RESULTS:     1) The minimum pulse width for GES to completely entrain the slow waves was similar (100-400   msec) in all four species. 2) With fixed amplitude (4   mA) and pulse width (400   msec), the highest frequency at which slow waves could be paced was similar (about 10-60% higher than the intrinsic slow wave frequency) in all species. 3) With fixed pulse width of 400   msec and amplitude of 6   mA, GES with nine to 18 cycles per min (cpm) was able to induce @entity943 in @entity235 . In addition, there was no significant difference among these frequencies of 9-18   cpm. 4) GES with 400   msec, 6   mA, and 9   cpm was able to induce @entity943 in all species. These effective GES parameters in results 1-4 were similar to those used in @entity1 in the literature. CONCLUSIONS:     There is no significant difference in stimulation parameters when GES is applied to alter gastric slow waves in different animal models. Furthermore, the effective parameters for GES to alter slow waves are similar between the @entity1 and various animal models. These findings suggest that stimulation parameters obtained from animal studies are applicable in @entity1 .

title: Gastric electrical stimulation with long pulses in XXXX and animals: can data obtained in animals be replicated in @entity1 ?

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['dysrhythmia', 'gastric dysrhythmia']

answer: @entity1 :: (9606,Species) :: ['humans']


abstract: PURPOSE: The purpose of this paper is to determine the repeatability of visual acuity measurement in @entity9042 and to describe the impact of measurement repeatability on sample size. METHODS: Approximately 10% of a 1209 @entity1 sample in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study were selected randomly for a Repeat CLEK Study Visit. @entity1 were tested at the 15 CLEK Participating Clinics. The test-retest sample consisted of 1 34 @entity9042 @entity1 who met the entry criteria of the CLEK Study. High and low contrast Bailey-Lovie visual acuity was measured with the @entity1 's habitual visual correction (entrance visual acuity monocularly and binocularly), and with the best correction monocularly (either the @entity1 's rigid contact lens and over-refraction, or with a CLEK Study trial lens and appropriate over-refraction) at two visits separated by a median of 90 days (range 22 to 268 days). RESULTS: The mean absolute differences between the number of letters correct at the two visits ranged from a low of 3.24 +/- 3.1 for entrance high contrast binocular acuity to a high of 5.48 +/- 5.1 for best corrected low contrast monocular acuity. Intraclass correlation coefficients ranged from 0.757 to 0.853. The visual acuity score was somewhat higher at the Repeat Visit than at the Baseline Visit when the examiners were different between visits. CONCLUSIONS: Given the variable vision reported by @entity9042 @entity1 , visual acuity in this sample was very repeatable. Repeatability was slightly poorer when different examiners tested visual acuity at the Baseline and Repeat Visits.

title: Visual acuity repeatability in XXXX : impact on sample size. Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study Group.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'Patients']

entities_list: @entity9042 :: ('MESH:D007640', 'Disease') :: ['keratoconus']

answer: @entity9042 :: (MESH:D007640,Disease) :: ['keratoconus']


abstract: BACKGROUND: The cognitive fusion questionnaire (CFQ) is a self-report questionnaire that assesses the extent to which individuals are psychologically entangled with, and dominated by the form-content of their thoughts. The aim of this study was to replicate the factor structure of CFQ in @entity66 , @entity6 , @entity28 , @entity308 , and normative population. It further examined the factorial invariance of the CFQ across these 5 groups. METHOD: Data from 299 @entity1 (N General Population   =  67, N @entity66   =  73, N @entity6   =  47, N @entity308   =  45, and N Obesity   =  60) were subjected to confirmatory factorial analysis ( @entity3795 ) to replicate the structural model of CFQ dimensionality. RESULTS: @entity3795 supported a 1-factor structure with good internal consistency and construct related validity. The 1-factor solution was also supported by a second independent data set, which showed a configural, strict measurement, and structural invariance of the 1-factor solution proposed. Multigroup @entity3795 showed the configural invariance, strict measurement invariance, and structural invariance of CFQ across the 5 groups under study. CONCLUSIONS: The unidimensional model has both similar meanings and the same structure, but the measurement model across the groups was not the same. The study provides the first approach to CFQ to Portuguese population, as a reliable tool of general cognitive fusion. Furthermore, results indicated that CFQ has a coherent structure across multiple samples and clinical utility, as it discriminate individuals with @entity458 from those who do not.

title: Validation of the psychometric properties of cognitive fusion questionnaire. A study of the factorial validity and factorial invariance of the measure among @entity66 , @entity6 , @entity28 , XXXX , and general populations.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depressive Disorder', 'depressive disorder']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['Osteoarticular Disease', 'osteoarticular disease']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['Diabetes Mellitus', 'diabetes mellitus']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['psychological distress']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depressive disorder']


abstract: UNASSIGNED: 1084 Background: @entity5345 -associated @entity0 have pathologic features and biologic behavior that are distinct from @entity0 while @entity2674 @entity5 are indistinguishable. Comparative survival studies have reported conflicting results and recent studies suggest relative resistance to @entity3907 -based chemotherapy in @entity1 with @entity5345 mutations. To determine if there are differences in long-term outcomes for @entity5345 , @entity2674 and high-risk non-carriers with @entity0 based on adjuvant therapy received, we conducted a retrospective analysis in US and Italian @entity1 . METHODS: @entity1 diagnosed with @entity0 between January 1, 1990 and December 31, 2008 were identified at the University of Chicago Cancer Risk Clinic and the Veneto Institute of Oncology in Padua. There were 80 @entity5345 carriers, 78 @entity2674 carriers and 177 high-risk non-carriers ascertained within the same time period. End points were @entity1349 ( @entity1349 ) and @entity1349 ( @entity1349 ) by type of adjuvant chemotherapy received. Hazard Ratios (HR) and 95% Confidence Intervals (95% CI) were calculated from Cox proportional hazard models. A multivariate analysis was used to adjust for year at diagnosis, stage, grade and @entity1782 (ER) status. RESULTS: The median follow up was 4.98 (0.03-18.9). The @entity1349 -adjusted hazard ratios were not significantly different among mutation carriers and non-carriers (HR among @entity5345 carriers, 0.52; 95% CI, 0.21 to 1.31; HR among @entity2674 carriers, 0.68; 95% CI, 0.31 to 1.48; P=0.326). The @entity1349 -adjusted hazard ratios were not significantly different (HR among @entity5345 carriers, 1.24; 95% CI, 0.45 to 3.45; HR among @entity2674 carriers, 0.89; 95% CI, 0.33 to 2.38; P=0.837). Ten year survival was 78% for @entity5345 , 83% for @entity2674 and 92% for non-carriers, respectively. The risk of recurrence and @entity204 was also not statistically significant among @entity1 treated with different chemotherapy regimens. CONCLUSIONS: @entity1349 and @entity1349 survival are similar for carriers of a BRCA mutation and non-carriers.

title: Adjuvant chemotherapy in American and Italian @entity1 with XXXX /2-associated @entity0 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1782 :: ('2099', 'Gene') :: ['Estrogen Receptor']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancers', 'breast cancer', 'sporadic breast tumors', 'stage I, II, and III breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumors']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'RFS', 'recurrence-free survival', 'overall survival']

answer: @entity5345 :: (672,Gene) :: ['BRCA1']


abstract: Immune cells infiltrating the microenvironment of melanoma @entity3 may either limit or promote @entity5 progression, but the characteristics that distinguish these effects are obscure. In this study, we systematically evaluated the composition and organization of immune cells that infiltrated melanoma @entity3 in @entity1 @entity1 . Three histologic patterns of immune cell infiltration were identified, designated immunotypes A, B, and C. Immunotype A was characterized by no immune cell infiltrate. Immunotype B was characterized by infiltration of immune cells limited only to regions proximal to intratumoral blood vessels. Immunotype C was characterized by a diffuse immune cell infiltrate throughout a @entity3 . These immunotypes represented 29%, 63%, and 8% of @entity3 with estimated median survival periods of 15, 23, and 130 months, respectively. Notably, from immunotypes A to C, there were increasing proportions of B cells and decreasing proportions of macrophages. Overall, the predominant immune cells were T cells (53%), B cell lineage cells (33%), and macrophages (13%), with natural killer and mature dendritic cells only rarely present. Whereas higher densities of @entity405 (+) T cells correlated best with survival, a higher density of @entity1195 (+) leukocytes, T cells, and B cells also correlated with increased survival. Together, our findings reveal striking differences in the immune infiltrate in melanoma @entity3 in @entity1 , suggesting microenvironmental differences in immune homing receptors and ligands that affect immune cell recruitment. These findings are important, not only by revealing how the immune microenvironment can affect outcomes but also because they reveal characteristics that may help improve individualized therapy for @entity1 with @entity320 .

title: Immunotype and immunohistologic characteristics of @entity5 -infiltrating immune cells are associated with clinical outcome in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastases', 'metastatic tumor']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['metastatic melanoma']

answer: @entity320 :: (MESH:D008545,Disease) :: ['metastatic melanoma']


abstract: Scaling up of insecticide treated nets has contributed to a substantial @entity311 decline. However, some @entity311 vectors, and most arbovirus vectors, bite outdoors and in the early evening. Therefore, topically applied insect repellents may provide crucial additional protection against mosquito-borne pathogens. Among topical repellents, DEET is the most commonly used, followed by others such as @entity15916 . The protective efficacy of two formulated @entity15916 repellents against mosquito bites, including arbovirus and @entity311 vectors, was evaluated in a field study in Cambodia. Over a period of two years, @entity1 landing collections were performed on repellent treated @entity1 , with rotation to account for the effect of collection place, time and individual collector. Based on a total of 4996 mosquitoes collected on negative control @entity1 , the overall five hour protection rate was 97.4% [95%CI: 97.1-97.8%], not decreasing over time. @entity15916 20% performed equally well as DEET 20% and better than @entity15916 10%. Repellents performed better against Mansonia and Culex spp. as compared to aedines and anophelines. A lower performance was observed against @entity197 as compared to @entity4224 , and against Anopheles barbirostris as compared to several vector species. Parity rates were higher in vectors collected on repellent treated @entity1 as compared to control @entity1 . As such, field evaluation shows that repellents can provide additional personal protection against early and outdoor biting @entity311 and arbovirus vectors, with excellent protection up to five hours after application. The heterogeneity in repellent sensitivity between mosquito genera and vector species could however impact the efficacy of repellents in public health programs. Considering its excellent performance and potential to protect against early and outdoor biting vectors, as well as its higher acceptability as compared to @entity2471 , @entity15916 is an appropriate product to evaluate the epidemiological impact of large scale use of topical repellents on arthropod borne diseases.

title: Field Evaluation of XXXX Repellents Reveals Differences in Repellent Sensitivity between Southeast Asian Vectors of @entity311 and Arboviruses.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'person', 'persons']

entities_list: @entity4224 :: ('7159', 'Species') :: ['Aedes aegypti']

entities_list: @entity197 :: ('7160', 'Species') :: ['Aedes albopictus']

entities_list: @entity15916 :: ('MESH:C483506', 'Chemical') :: ['picaridin', 'Picaridin']

answer: @entity15916 :: (MESH:C483506,Chemical) :: ['Picaridin']


abstract: BACKGROUND: Minimal @entity1985 (MCNS) in @entity1 frequently is associated with @entity566 and immunoglobulin E production. T Helper subtype 2 cytokines, such as @entity3646 ( @entity3646 ), may have an important role in the development of @entity402 . We investigated the associations of gene polymorphisms of @entity69997 ( @entity9597 ), and the @entity8850 ( @entity8850 ) gene with MCNS. METHODS: We analyzed these polymorphisms in Japanese @entity1 with MCNS (n = 58) and healthy controls with neither allergic nor @entity8 (n = 63). The polymerase chain reaction (PCR) and restriction fragment length polymorphism method was used for the @entity3646 promoter gene polymorphism ( @entity8997 ), and PCR single-strand conformation polymorphism analysis was used for the @entity9597 chain gene ( @entity69998 ) and @entity8850 3' untranslated region ( @entity69999 ) polymorphisms. RESULTS: There was a significant difference between the MCNS group and controls in genotypic distribution of @entity3646 promoter gene polymorphism. Frequency of the T allele was significantly lower in the MCNS group than controls. There was no difference between the MCNS group and controls in the @entity9597 gene polymorphism. In the @entity8850 gene, no significant differences in genotypic and allelic distribution were observed between the 2 groups. However, there were significant differences between @entity1 who did not need cytotoxic agents or who experienced 3 or fewer relapses and controls. CONCLUSION: These results suggest that genetic variations in the @entity3646 and @entity8850 genes may be associated with predisposition to MCNS, partially the clinical course of MCNS.

title: Polymorphisms of @entity3646 --related genes in Japanese XXXX with minimal @entity1985 .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients']

entities_list: @entity8 :: ('MESH:D007674', 'Disease') :: ['renal disease']

entities_list: @entity8850 :: ('6778', 'Gene') :: ['signal transducer and activator 6', 'STAT6']

entities_list: @entity1985 :: ('MESH:D009404', 'Disease') :: ['change nephrotic syndrome']

answer: @entity1 :: (9606,Species) :: ['children']


abstract: UNASSIGNED: Objective. To explore whether GC (group-specific component) @entity69032 , @entity69033 , and @entity69034 polymorphisms are associated with generalized aggressive @entity2521 . Methods. This case-control study recruited 372 @entity1 with generalized aggressive @entity2521 (group AgP) and 133 periodontal healthy subjects (group HP). GC @entity69032 , @entity69033 , and @entity69034 genotypes and plasmatic @entity12095 ( @entity13520 ) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic @entity13520 and haplotypes was analyzed. Results. GC @entity69032 GG genotype was statistically associated with lower risk for generalized aggressive @entity2521 under the recessive model (OR = 0.52, 95% CI: 0.30-0.92, p = 0.028). GC @entity69032 and @entity69033 had strong linkage disequilibrium with r(2) >=  0.8 and D' >=  0.8. Haplotype (GC @entity69032 , @entity69033 ) GC was associated with the less risk for generalized aggressive @entity2521 (OR = 0.29, 95% CI: 0.09-0.96, p = 0.043). In group AgP, individuals with combined genotype (GC @entity69032 , @entity69033 ) AG+CA had significantly lower plasmatic @entity13520 level than those with the other two combined genotypes (AG+CA versus AA+CC p = 0.007; AG+CA versus GG+AA p = 0.026). Conclusions. GC @entity69032 genotype GG and haplotype (GC @entity69032 , @entity69033 ) GC are associated with generalized aggressive @entity2521 . The association may be acquired through regulating @entity13520 levels. The functions of GC gene and @entity13520 in @entity32 need to be further studied.

title: GC Gene Polymorphisms and XXXX Levels Are Related to the Risk of Generalized Aggressive Periodontitis.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammatory disease']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis']

entities_list: @entity12095 :: ('2638', 'Gene') :: ['vitamin D-binding protein']

answer: @entity12095 :: (2638,Gene) :: ['Vitamin D-Binding Protein']


abstract: BACKGROUND: Extracorporeal shockwave therapy is a conservative treatment for several @entity4512 . The aim of the study was the assessment of the relief from @entity158 by the shockwave therapy in a population of consecutive @entity1 affected by specific pathologies. MATERIALS AND METHODS: A group of consecutive @entity1 were studied and treated. They were affected by @entity730 of the shoulder (129 @entity1 ), @entity924 (102 @entity1 ), and @entity2633 of the elbow (80 subjects). Each @entity1 had 3 applications with a monthly interval, and was followed up at 1, 6, and 12  months after treatment. Results were evaluated by the numeric rating scale (NRS) in all cases, the Constant Murley Score for the assessment of the shoulder function, the American Orthopaedic Foot and Ankle Society Score for subjects affected by @entity924 , and the Oxford Elbow Score for those affected by a @entity2633 of the elbow. RESULTS: One year after treatment, the results were considered satisfactory with an almost complete resolution of symptoms. There were statistically significant results at the 12-month follow-ups regarding the mean NRS score (from 6.25 to 0.2), the Constant Murley Score (from 66.7 to 79.4), the Oxford Elbow Score (from 28 to 46), and the AOFAS (from 71 to 86). CONCLUSIONS: Extracorporeal shockwave therapy may be considered a safe, economic, and effective treatment for several chronic @entity85 , allowing satisfactory @entity158 relief and improvement of function ability. LEVEL OF EVIDENCE: Level IV.

title: Effectiveness of extracorporeal shockwave therapy in three major XXXX .

entities_list: @entity4512 :: ('MESH:D059352', 'Disease') :: ['painful musculoskeletal disorders']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity924 :: ('MESH:D052256', 'Disease') :: ['chronic Achilles tendinopathy']

entities_list: @entity730 :: ('MESH:D002114', 'Disease') :: ['calcific tendonitis']

entities_list: @entity2633 :: ('MESH:D013716', 'Disease') :: ['lateral epicondylitis']

entities_list: @entity85 :: ('MESH:D009140', 'Disease') :: ['musculoskeletal disorders']

answer: @entity924 :: (MESH:D052256,Disease) :: ['tendon diseases']


abstract: OBJECTIVE: To evaluate the effect of @entity4044 extract (GBE) on preexisting @entity227 in @entity1 with normal tension @entity726 (NTG). DESIGN: Prospective, randomized, placebo-controlled, double-masked cross-over trial. @entity1 : Twenty-seven @entity1 with bilateral @entity227 resulting from NTG. INTERVENTION: @entity1 received 40 mg GBE, administered orally, three times daily for 4 weeks, followed by a wash-out period of 8 weeks, then 4 weeks of placebo treatment (identical capsules filled with 40 mg @entity948 ). Other @entity1 underwent the same regimen, but took the placebo first and the GBE last. Visual field tests, performed at baseline and at the end of each phase of the study, were evaluated for changes. MAIN OUTCOME MEASURES: Change in visual field and any @entity149 . RESULTS: After GBE treatment, a significant improvement in visual fields indices was recorded: @entity5494 ( @entity5494 ) at baseline versus @entity5494 after GBE treatment, 11.40 +/- 3.27 dB versus 8.78 +/- 2.56 dB (t = 8.86, P = 0.0001, chi-square test); corrected pattern standard deviation (CPSD) at baseline versus CPSD after GBE treatment, 10.93 +/- 2.12 dB versus 8.13 +/- 2.12 dB (t = 9.89, P = 0.0001, chi-square test). No significant changes were found in intraocular pressure, blood pressure, or heart rate after placebo or GBE treatment. Any ocular and systemic side effects were recorded for the duration of the trial. CONCLUSIONS: @entity4044 extract administration appears to improve preexisting @entity227 in some @entity1 with NTG.

title: Effect of XXXX extract on preexisting @entity227 in normal tension @entity726 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field damage']

entities_list: @entity5494 :: ('MESH:D010262', 'Disease') :: ['mean deviation', 'MD']

entities_list: @entity948 :: ('MESH:D005632', 'Chemical') :: ['fructose']

entities_list: @entity149 :: ('MESH:D002493', 'Disease') :: ['ocular or systemic complications']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity4044 :: ('3311', 'Species') :: ['Ginkgo biloba']

answer: @entity4044 :: (3311,Species) :: ['Ginkgo biloba']


abstract: OBJECTIVE: Infantile @entity13785 is a lethal @entity299 . Current developments toward enzyme replacement therapy are promising. The aim of our study is to delineate the natural course of the disease to verify endpoints of clinical studies. METHODS: A total of 20 infantile @entity1 diagnosed by the collaborative Dutch centers and 133 cases reported in literature were included in the study. Information on clinical history, physical examination, and diagnostic parameters was collected. RESULTS: The course of @entity13785 is essentially the same in the Dutch and the general @entity1 population. Symptoms start at a median age of 1.6 months in both groups. The median age of death is 7.7 and 6 months, respectively. Five percent of the Dutch @entity1 and 8% of all reported @entity1 survive beyond 1 year of age. Only 2 @entity1 from literature became older than 18 months. A progressive @entity1283 is characteristic for @entity13785 . The diastolic thickness of the left ventricular posterior wall and cardiac weight at autopsy increase significantly with age. Motor development is severely delayed and major developmental milestones are generally not achieved. For the Dutch @entity1 group, growth deviates significantly from normal despite start of nasogastric tube feeding. Levels of @entity492 aminotransferase, @entity493 aminotransferase, @entity880 dehydrogenase, @entity908 kinase, or @entity908 kinase-myocardial band isoenzyme are typically elevated, although @entity492 aminotransferase, @entity493 aminotransferase, and @entity880 dehydrogenase increase significantly with age. The @entity1 have fully deleterious mutations. Acid alpha-glucosidase activity is severely deficient. CONCLUSIONS: Survival, decrease of the diastolic thickness of the left ventricular posterior wall, and achievement of major motor milestones are valid endpoints for therapeutic studies of @entity13785 . Mutation analysis and measurement of the alpha-glucosidase activity should be part of the enrollment program.

title: The natural course of XXXX : 20 original cases compared with 133 cases from the literature.

entities_list: @entity1283 :: ('MESH:D006332', 'Disease') :: ['cardiac hypertrophy']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity13785 :: ('MESH:D006009', 'Disease') :: ["infantile Pompe's disease", "Pompe's disease"]

entities_list: @entity492 :: ('CHEBI:29995', 'Chemical') :: ['aspartate']

entities_list: @entity880 :: ('MESH:D019344', 'Chemical') :: ['lactate']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac and muscular disorder']

entities_list: @entity493 :: ('CHEBI:16449', 'Chemical') :: ['alanine']

answer: @entity13785 :: (MESH:D006009,Disease) :: ['infantile Pompe's disease']


abstract: The N @entity19 oligodendroglial cell line, immortalized with SV40 T antigen, simultaneously expresses oligodendroglial markers and @entity9327 ( @entity9327 ), an astroglial marker. This study examines the plasticity of N @entity19 cells with regard to @entity9327 expression, and its relationship to expression of SV40 T antigen, @entity899 , and a novel nuclear antigen detected by the A007 monoclonal antibody. Marked changes occur in @entity9327 levels and cell morphology when N @entity19 cells are switched from the permissive temperature (34 degrees C) to the non-permissive temperature (39 degrees C), and with @entity1919 elevation at 39 degrees C. At 34 degrees C, levels of @entity9327 are high; when cells are switched to 39 degrees C, @entity9327 levels decrease significantly, then increase slightly when @entity1928 is added. At both temperatures, the cells display feathery @entity9327 immunostaining. When @entity1928 is added at 39 degrees C, however, cells display bright fibrous @entity9327 staining in elongated processes. The changes in @entity9327 were compared to changes in T antigen and @entity899 . As expected, the decrease in T antigen at 39 degrees C was accompanied by movement of @entity899 from the nucleus to cytoplasm. Total @entity899 levels did not change, however, and @entity1928 did not alter the respective distribution or levels of @entity899 at either temperature. At both temperatures, the cell bodies and processes show internal expression of sulfatide, as demonstrated with the O4, Sulph I, and A007 antibodies. We show, for the first time, abundant nuclear immunoreactivity with the A007 monoclonal antibody in the N @entity19 cells. This nuclear reactivity is seen at 34 degrees C, but not at 39 degrees C, similar to @entity899 , and is not detected with the other @entity10839 antibodies. Double-label immunostaining shows that the nuclear A007 immunoreactivity is co-localized in nuclear structures with T antigen and @entity899 at 34 degrees C, but is not found in every nucleus containing these antigens. We conclude that regulation of @entity9327 expression and morphology in N @entity19 cells is dependent on a combination of T antigen expression and level of @entity268 and may be related to regulation of @entity899 and the A007 nuclear antigen.

title: Regulation of CNS glial phenotypes in N XXXX cells.

entities_list: @entity9327 :: ('14580(Tax:10090)', 'Gene') :: ['glial fibrillary acidic protein', 'GFAP']

entities_list: @entity1919 :: ('MESH:D000242', 'Chemical') :: ['cyclic AMP']

entities_list: @entity10839 :: ('CHEBI:18318', 'Chemical') :: ['sulfatide']

entities_list: @entity1928 :: ('MESH:D005576', 'Chemical') :: ['forskolin']

answer: @entity19 :: (10090,Species) :: ['20.1']


abstract: BACKGROUND: Although the standard of care after recurrence of @entity43 ( @entity43 ) is chemotherapy, increasing data suggest that combining cytoreductive surgery with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising option for @entity1 with recurrent @entity43 . Our aim was to determine the prognostic value of the addition of HIPEC to secondary cytoreductive surgery (SCR) in recurrent @entity43 . METHODS: We analyzed a series of 79 @entity1 with @entity902 -sensitive recurrent @entity43 who were treated from May 2000 to January 2014. Fifty @entity1 who underwent SCR were compared to 29 who had SCR in combination with HIPEC. RESULTS: The SCR group had a higher median age (58.4  years) compared to the SCR  +  HIPEC group (51.6  years) (p  =  0.006). The median hospital stay length was longer for SCR  +  HIPEC versus SCR @entity1 (11 and 8  days, respectively; p  =  0.009). More subjects experienced National @entity5 Institute grade III-IV morbidity in the SCR  +  HIPEC group (34.5  %) compared to the SCR group (10.6  %) (p  =  0.015). Conversely, there were no deaths in the SCR  +  HIPEC group and 2 (4.0  %) deaths the SCR group. The median disease-free survival did not differ between SCR and SCR  +  HIPEC @entity1 (18.6 and 15.8  months, respectively; p  =  0.82); nor did median overall survival (59.3 and 58.3  months, respectively; p  =  0.95). The presence of @entity189 was the only variable that remained linked to a higher risk of recurrence and @entity204 in the multivariate analysis. CONCLUSIONS: Our data suggest that the addition of HIPEC to cytoreduction in @entity1 with recurrent @entity902 -sensitive @entity43 does not improve survival.

title: Hyperthermic Intraperitoneal Chemotherapy after Secondary Cytoreduction in XXXX : A Single-center Comparative Analysis.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['EOC', 'epithelial ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['Cancer']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomatosis']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

answer: @entity43 :: (MESH:D010051,Disease) :: ['Epithelial Ovarian Cancer']


abstract: BACKGROUND: The psychopathological and clinical characteristics of adult @entity1 with @entity302 attending our neurology clinic were evaluated to determine prevalence of psychopathology and its associated factors towards improving services and initiating collaborative care which is currently nonexistent. METHODS: The study was a two-stage procedure conducted over 1 year using the General Health Questionnaire in the first stage and Schedule for Clinical Assessment in Neuropsychiatry in the second stage. Diagnosis of @entity146 was based on International Classification of Diseases: 10th Revision criteria. RESULTS: Sixty-three @entity1 were interviewed. Mean age was 34.43    13.7 years; more than half of the @entity1 had less than one @entity410 episode per month. Fourteen @entity1 (22.2%) had @entity302 ; 40 (63.5%), generalized; and 9 (14.3%), unclassified @entity410 . The rate of @entity146 morbidity was found to be 28.6%. @entity308 were the most common (66.7%), followed by @entity914 (11.1%), @entity148 (11.1%) and @entity303 (11.1%). Psychopathology was more common in @entity1 (P=.007), those older than 40 years (P=.038) and those with @entity302 (P=.017). CONCLUSION: About one third of @entity1 with @entity302 studied had undetected and untreated psychopathology. Our neurology clinic urgently needs currently nonexistent collaborative care involving neurologists, psychiatrists and primary care physicians in order to improve the mental health of the @entity1 with @entity302 .

title: Prevalence and clinical implications of psychopathology in adults with XXXX seen in an outpatient clinic in Nigeria.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['seizure', 'seizures']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depressive disorders']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'psychiatric disorders']

entities_list: @entity303 :: ('MESH:D003704', 'Disease') :: ['dementia']

entities_list: @entity914 :: ('MESH:D011618', 'Disease') :: ['psychotic disorders']

entities_list: @entity148 :: ('MESH:D001008', 'Disease') :: ['anxiety disorders']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy', 'partial epilepsy']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: PURPOSE: We generated a @entity1501 -conjugated @entity7170 nanoparticle (porphysome) suitable for multimodal non-invasive active macrophage tracking @entity583 ( @entity583 ). PROCEDURES: Macrophage uptake of @entity1501 -conjugated porphysomes was selective. @entity1501 -porphysome cardiac macrophage tracking was detected in vivo using radioligand and fluorescent imaging. To track post- @entity583 macrophage mobilization, cardiac fluorescence signal in @entity1501 -porphysome-injected @entity19 was measured for 9  day post- @entity583 . Active macrophage phenotype was assessed using immunohistochemistry. RESULTS: Heart active macrophage presence peaked on day 1, returned to baseline by day 3, and peaked again on day 7 post- @entity583 . Macrophages were distributed throughout the left ventricle at day 1, but aggregated within scar tissue at day 7. Macrophage phenotype was pro-inflammatory ( @entity637 (+)) at day 1, whereas scar-resident macrophages expressed anti-inflammatory markers ( @entity1618 , @entity641 ) at day 7. However, day 7 macrophages outside the scar expressed neither pro- nor anti-inflammatory markers. CONCLUSIONS: We established that @entity1501 -porphysomes are suitable for non-invasive imaging of macrophages and used it to investigate active macrophage behavior in the infarcted heart.

title: Non-invasive Macrophage Tracking Using Novel Porphysome Nanoparticles in the Post- XXXX @entity19 Heart.

entities_list: @entity1501 :: ('MESH:D005492', 'Chemical') :: ['Folate', 'folate']

entities_list: @entity7170 :: ('CHEBI:8337', 'Chemical') :: ['porphyrin']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['MI', 'post-myocardial infarction']

answer: @entity583 :: (MESH:D009203,Disease) :: ['myocardial Infarction']


abstract: Authors present comparison of the previous results on the influence of free @entity1522 of the @entity7462 in @entity95 and @entity1 on the pH of the @entity7462 in vitro. Four clinically used antiglaucomatics were added (2% Trusopt--pH 5.33; 0,005% Xalatan--pH 6.4; 0.5% @entity6839 --pH 6.80 and 1% @entity2134 --pH 5.87) into the aquired @entity7462 of @entity95 (pH 7.59) and @entity1 (pH 7.11 +/- 0.11). After their instillation pH of the @entity7462 immediately decreased towards acid levels. The pH changes after @entity6839 , Xalatan and @entity2134 showed a similar time pattern and after return to the baseline values the pH shifted to alkaline levels. In case of Trusopt instillation the pH value reached the baseline of the @entity7462 after 240 min. Almost no pH changes were recorded from 240 min up to 24 hours after all tested antiglaucomatics. From the wiev on the speed of activity and effectivity depending on time required to reach the initial pH value of the @entity7462 we to make this order: @entity2134 > @entity6839 >Xalatan>Trusopt. Comparing our results the effect of antiglaucomatics is connected with different composition and also with shift of the @entity8487 towards slightly alkaline level (similar effect in @entity95 and @entity1 ). Results presented in this work are theoretical but also practical contribution to the treatment of @entity726 . (Fig. 1, Ref. 38.).

title: The free @entity1522 and the XXXX after antiglaucomatics in vitro.

entities_list: @entity1522 :: ('CHEBI:33709', 'Chemical') :: ['amino acids']

entities_list: @entity8487 :: ('MESH:D010677', 'Disease') :: ['aqueous humor pH']

entities_list: @entity6839 :: ('MESH:D013999', 'Chemical') :: ['Timoptol']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity2134 :: ('MESH:D010862', 'Chemical') :: ['Pilocarpine']

entities_list: @entity7462 :: ('MESH:C562390', 'Disease') :: ['aqueous humor']

answer: @entity8487 :: (MESH:D010677,Disease) :: ['aqueous humor pH']


abstract: INTRODUCTION: The 90-day risk of @entity385 in @entity1 with @entity4905 ( @entity4905 ) is estimated at between 8% and 20%. There is little consensus as to which diagnostic strategy is most effective. This study evaluates the benefits of early transthoracic echocardiography (TTE) with carotid and transcranial Doppler ultrasound in @entity1 with @entity4905 . METHODS: Prospective study of @entity1 with @entity4905 in an emergency department setting. Demographic data, vascular risk factors, and @entity13203 ) score were analysed. @entity4905 aetiology was classified according to TOAST criteria. All @entity1 underwent early vascular studies (<72hours), including TTE, carotid ultrasound, and transcranial Doppler. Primary endpoints were recurrence of @entity64 or @entity4905 , @entity583 ( @entity583 ), or @entity204 during the first year. RESULTS: We evaluated 92 @entity1 enrolled over 24 months. Mean age was 68.3  13 years and 61% were male. The mean @entity13203 ) score was 3 points (>= 5 in 30%). The distribution of @entity4905 subtypes was as follows: 12% large-artery @entity731 ; 30% cardioembolism; 10% small-vessel occlusion; 40% undetermined cause; and 8% rare causes. Findings from the early TTE led to a change in treatment strategy in 6 @entity1 (6.5%) who displayed normal physical examination and ECG findings. At one year of follow-up, 3 @entity1 had experienced @entity64 (3.2%) and 1 @entity1 experienced @entity583 (1%); no vascular @entity204 were identified. CONCLUSIONS: In our @entity4905 @entity1 , early vascular study and detecting @entity1 with silent @entity296 may have contributed to the low rate of @entity455 recurrence.

title: Rapid diagnosis and treatment of @entity4905 results in low rates of @entity64 , @entity583 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['cardiomyopathy']

entities_list: @entity455 :: ('MESH:D014652', 'Disease') :: ['vascular disease']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerosis']

entities_list: @entity4905 :: ('MESH:D002546', 'Disease') :: ['transient ischaemic attack', 'TIA']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI']

entities_list: @entity204 :: ('MESH:D003643', 'Disease') :: ['vascular death', 'deaths']

entities_list: @entity385 :: ('MESH:D002544', 'Disease') :: ['cerebral infarction']

answer: @entity204 :: (MESH:D003643,Disease) :: ['vascular death']


abstract: Severe @entity425 is an infrequent symptom in the course of lumbar @entity850 . The objectives of this study are threefold: to describe the @entity51 , evaluate the prognosis factors, and determine the type of @entity850 most likely to be complicated by motor loss. Fifty consecutive @entity1 with a mean age of 65 years, operated on for @entity2649 and with a severe @entity51 , have been retrospectively studied with a mean follow-up of 38 months. The overall functional result was evaluated according to the Beaujon scoring system. The motor capacity was rated from 0 (complete paralysis) to 5 (normal strength). Prognosis factors were investigated with a multivariate analysis model. Motor weakness was rated as zero 11 times, as one 8 times, as two 8 times, and as three 23 times. According to our rating scale, the overall results were considered excellent in 25 cases, good in 17 cases, and fair in the 8 remaining cases. @entity425 was complete 15 times, partial 25 times, and null 10 times. In this study, favorable prognosis parameters of @entity425 recovery were as follows: association with a discal herniation, @entity850 at one level, preoperative duration of @entity425 <6 weeks, age <65, and monoradicular deficit. In contrast, severity of the initial @entity425 , association with @entity1690 , presence or not of degenerative spondylolisthesis, or of a complete block on the myelogram were not influential variables.

title: @entity51 in @entity2649 : a retrospective study of a series of 50 XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1690 :: ('MESH:D046628', 'Disease') :: ['sphincter abnormalities']

entities_list: @entity2649 :: ('MESH:C563613', 'Disease') :: ['a lumbar stenosis']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['motor weakness', 'Regression of motor weakness']

entities_list: @entity51 :: ('MESH:D009461', 'Disease') :: ['motor deficit']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: UNASSIGNED: This paper presents the first ever paleodontological investigation of @entity1 remains from an archeological site in Central Europe dating from the Early Bronze Age and attributed to the Strzyzow Culture. It corroborates the knowledge gained from archeological, anthropological and genetical investigations. Our study aimed to assess dental status, dental morphology and dental pathologies as well as @entity3356 and @entity2193 based on visual inspection and stereomicroscopic investigation. The research was supported by CBCT imaging to obtain digital images and 3D reconstructions as well as 2D radiographs essential for dental age estimation. All of the 191 teeth discovered showed morphological similarity, with adult teeth showing similar color, shape and size. A maxillary molar presenting with a unique root morphology and a mandibular molar with a rare occlusal surface were found. Both permanent and deciduous dentition presented significant @entity3356 . A few specimens displayed signs of @entity1547 , periapical pathology and antemortem @entity2524 . Three individuals exhibited @entity2193 . CBCT provided high-quality 2D images useful for dental age estimation by non-destructive methods. Estimated dental age correlated with the age estimated by other anthropological methods. In one case, this was crucial because of insufficient material for anthropological analysis. The presented studies have proved that besides the skeleton, teeth can be used as a fundamental tool in assessing the overall health and living conditions of paleopopulations. It would seem that there is potential for considerable development to be made in the research and investigation of paleodontological material using CBCT.

title: Analysis of XXXX dentition from Early Bronze Age: 4000-year-old puzzle.

entities_list: @entity3356 :: ('MESH:D057085', 'Disease') :: ['tooth wear']

entities_list: @entity1547 :: ('MESH:D003731', 'Disease') :: ['dental caries']

entities_list: @entity2524 :: ('MESH:D016388', 'Disease') :: ['tooth loss']

entities_list: @entity2193 :: ('MESH:D003744', 'Disease') :: ['enamel hypoplasia', 'linear enamel hypoplasia']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: The purpose of this study was to establish an efficient combination of assisted hatching and cryopreservation procedures for producing @entity291 embryos in vitro. A total of 1312 day 7 blastocysts were subjected randomly to 14 different combinations of three factors: osmotic stress, assisted hatching and vitrification. Re-expansion, initiation and completion of the hatching process, as well as attachment to the culture dish, were analysed by SAS Genmod procedure. Incubation with @entity969 was found to decrease survival rates; among the assisted hatching procedures used, zona fenestration resulted in higher survival rates compared with partial zona dissection and controls; and vitrification decreased survival and further development. The combined effect of @entity969 incubation and vitrification decreased further development markedly, as did partial zona dissection followed by vitrification. Partial zona dissection performed in medium containing @entity969 severely lowered embryo survival. Zona fenestration without @entity969 incubation followed by vitrification did not compromise further embryo development: 86%, 84% and 79% of the blastocysts initiated, completed hatching and attached to the bottom, respectively. These data were not different from the controls (80%, 76% and 63%, respectively; P > 0.05). Cell count analysis revealed a decrease in the total number of cells as a result of the assisted hatching and vitrification compared with controls (135 versus 202, respectively; P < 0.0001). Although embryo transfer results (36% pregnancy rate and 30% calving rate) require further improvement, this combination of methods may prove useful in the commercial production of @entity291 embryos in vitro.

title: Survival and development of XXXX blastocysts produced in vitro after assisted hatching, vitrification and in-straw direct rehydration.

entities_list: @entity969 :: ('MESH:D013395', 'Chemical') :: ['sucrose']

answer: @entity291 :: (9913,Species) :: ['bovine']


abstract: PURPOSE: To evaluate a @entity4530 -like finding in an eye with @entity726 using anterior-segment optical coherence tomography (AS-OCT). METHODS: A 35-year-old @entity1 complained of sudden-onset @entity3856 . She had been diagnosed with @entity1036 at 1.5 years old and the onset of secondary @entity726 was identified at 13 years old. At the age of 26 years, transscleral contact diode laser cyclophotocoagulation therapy was performed, except for the upper quadrant, because scleral thinning was noted at that time. At the age of 35 years, she was blind in her right eye and @entity5575 and a @entity4530 -like structure in the upper conjunctiva was seen with a slit-lamp examination. This @entity4530 -like structure was removed surgically at bulbar exenteration, and the pathology was examined. RESULTS: AS-OCT showed a @entity4530 -like internal structure with a single large empty space and thin scleral tissue and relatively thin walls with high optical density. Pathology indicated that the high optical density @entity4530 wall was connective tissue. On AS-OCT, the internal surface of the empty space was very smooth, which matched the pathology. Histochemically, there were goblet cells, as in normal conjunctiva, but not in the conjunctiva over the aqueous space. CONCLUSIONS: AS-OCT images found that the intrableb structure was in good agreement with the pathology results; these conjunctival changes were very similar to those after a standard trabeculectomy.

title: Bleb-like Finding Caused by Idiopathic Scleral Thinning in an Eye With XXXX .

entities_list: @entity1036 :: ('MESH:D007634', 'Disease') :: ['keratitis']

entities_list: @entity5575 :: ('MESH:D003318', 'Disease') :: ['corneal opacity']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['absolute glaucoma', 'glaucoma']

entities_list: @entity3856 :: ('MESH:D058447', 'Disease') :: ['pain in the right eye']

answer: @entity726 :: (MESH:D005901,Disease) :: ['Absolute Glaucoma']


abstract: PURPOSE: To evaluate the response rates, toxicitiesy, and survival rates, to @entity1206 ( @entity1206 (R)), @entity900 and @entity1260 combination chemotherapy, of the @entity1 with inoperable NSCLC (stage III and IV), who received @entity1206 ( @entity1206 (R)), @entity900 , @entity1260 combinationthe mentioned chemotherapy every 4 weeks. MATERIALS AND METHODS: This study included 26 @entity1 with inoperable NSCLC (stage III and IV), who attended St. Vincent's Hospital Bbetween April 1999 and December 2001, 26 @entity1 were included at St.Vincent's Hospital. The chemotherapy regimen consisted of @entity1206 (25 mg/m2 on days 1 and 8), @entity1260 (1,500 mg/m2 on days 1- and 2 with @entity9614 ), and @entity900 (30 mg/m2 on days 1- to 3). The cycles were administered every 4 weeks. A 25% reduction in the doses reduction was applied into subsequent courses if there werewas grade 3~4 @entity1398 . RESULTS: The median age was 63 (range, 44~73) years and the male : to female ratio was 19 : 7. One @entity1 had stage IIIa, 6 had stage IIIb and 19 had stage IV. Twenty two @entity1 had an ECOG performance status of 0 or 1, andwith 4 hadhave one of 2. Eighteen of the @entity1 had @entity420 , 7 had @entity957 , and 1 had an undifferentiated NSCLC. Two @entity1 were innot able to be evaluatedble due to follow-up loss. Among Of the 24 @entity1 able to be evaluatedble @entity1 , 1 @entity1 had a complete response and 9 @entity1 hada partial responses, and thewith an overall response rate wasof 41.7%. During a total of 104 cycles, grade 3 @entity1398 occurred in 29%, grade 4 @entity1398 in 12%, grade 3~4 @entity882 in 4%, grade 3 @entity417 in 11%, and grade 3~4 @entity33 in 2%. The mean time to progression was 6.4 months (range 1~13) and the median overall survival was 10 months (range 1.5~32). CONCLUSION: The combination of @entity1206 , @entity1260 and @entity900 , in the dose and schedule employed in this study, shows an response rate of 41.7%, but, because grade 3- or 4 @entity1398 occurred in 41%, a careful investigation is needed.

title: Effect of @entity1206 , @entity1260 and XXXX Combination Chemotherapy in Stage III-IV Non-Small-Cell Lung Cancer.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity882 :: ('MESH:D013921', 'Disease') :: ['thrombocytopenia']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinomas']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin']

entities_list: @entity33 :: ('MESH:D052016', 'Disease') :: ['mucositis']

entities_list: @entity1206 :: ('MESH:C030852', 'Chemical') :: ['vinorelbine', 'Navelbine']

entities_list: @entity1398 :: ('MESH:D009503', 'Disease') :: ['neutropenia']

entities_list: @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity900 :: (MESH:D002945,Chemical) :: ['Cisplatin']


abstract: BACKGROUND: Despite the progress that has been achieved in the last years, recurrence rates in @entity43 @entity1 are still considerably high and the majority of @entity1 ultimately become candidates for second-line treatment. @entity3003 reinduction is a broadly adopted regimen in @entity1 with recurrences occurring six months or later after first-line treatment. @entity136 is among the candidates as combination partner in second-line regimens. @entity1 AND METHODS: We performed a study with escalating doses of @entity136 combined with @entity3003 in 26 @entity902 -pretreated @entity1 with recurrent @entity43 and a treatment-free interval of 6+ months. Dose-limiting @entity137 (DLT) and a maximum tolerable dose (MTD) recommendable for further trials was evaluated. RESULTS: The DLT was myelosuppression, mainly @entity882 . No dose limiting non-hematological @entity137 were observed. The MTD of @entity136 was 1,000 mg/m2 given on days 1 + 8 of a three-week schedule combined with @entity3003 AUC 4 given on day 1. The majority of evaluable @entity1 showed an objective response (62.5%), and median progression-free and overall survival were 10 and 18+ months, respectively. CONCLUSION: @entity136 - @entity3003 given according to the MTD is well tolerated and active against recurrent @entity902 -sensitive disease. A randomized trial comparing @entity3003 with or without @entity136 in @entity902 -sensitive @entity43 has already been initiated.

title: Second-line XXXX and @entity136 in @entity902 sensitive @entity43 --a dose-finding study by the Arbeitsgemeinschaft Gyn  kologische Onkologie (AGO) @entity43 Study Group.

entities_list: @entity43 :: ('MESH:D010051', 'Disease') :: ['ovarian cancer']

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity902 :: ('MESH:D010984', 'Chemical') :: ['platinum']

entities_list: @entity3003 :: ('MESH:D016190', 'Chemical') :: ['Carboplatin', 'carboplatin']

entities_list: @entity136 :: ('MESH:C056507', 'Chemical') :: ['Gemcitabine', 'gemcitabine']

answer: @entity3003 :: (MESH:D016190,Chemical) :: ['carboplatin']


abstract: @entity1290 may be removed without using a surgical incision by a combination of techniques and skills recently developed in the fields of urology and radiology. Percutaneous access to the kidney is established under fluoroscopic control. A guide wire placed into the renal pelvis allows a nephroscope to be inserted and the collecting system visualized. A long hollow metal probe is advanced through the nephroscope and placed in contact with the stone. This probe conducts the ultrasonic energy. The stone absorbs the energy and breaks into fine granules which are evacuated by suction. Percutaneous lithotomy was performed upon 300 of 302 consecutive @entity1 bearing stones which required removal. Targeted calculi were successfully removed from 97 per cent of these @entity1 . Eighty-one per cent had complete stone removal at the primary procedure; 57 @entity1 required additional percutaneous manipulations under local or general anesthesia. The previous 100 @entity1 with @entity1290 underwent surgical removal of the calculi. Complications associated with percutaneous stone removal included @entity86 , delayed @entity548 , ureteral @entity4 , symptomatic urinary extravasation and @entity11896 . Only 16 @entity1 with complications required prolonged hospitalization or readmission. No complications required surgical management; no @entity204 occurred. Anesthetic times were similar for both groups, averaging 152 +/- 4 (S. E. M.) minutes for PL and 193 +/- 8 minutes for SL. Hospital recovery days averaged 5.7 +/- 0.3 for PL and 8.4 +/- 0.5 for SL (p less than 0.01). Associated costs averaged  7,203 +/- 255 for PL and  8,849 +/- 660 for SL (p less than 0.01). The number of narcotic administrations per @entity1 (days one to five postoperatively) averaged 9.9 +/- 0.7 for the PL group and 16.8 +/- 0.8 for the SL group (p less than 0.01). The average @entity1 in the PL group felt capable of full activity 2.0 +/- 0.2 weeks after stone removal, whereas no @entity1 who experienced previous SL recalls a recovery period of less than three weeks (p less than 0.01). Most upper urinary tract calculi may be removed cost-effectively using a percutaneous approach. @entity1 may expect a rapid convalescence with diminished @entity158 .

title: Percutaneous ultrasonic versus surgical XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity11896 :: ('MESH:D014869', 'Disease') :: ['water intoxication']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['urinary bleeding']

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['kidney stones', 'Kidney stones']

entities_list: @entity86 :: ('MESH:D019106', 'Disease') :: ['postoperative fever']

answer: @entity1290 :: (MESH:D007669,Disease) :: ['removal of kidney stones']