abstract: UNASSIGNED: The Tabapu   breed is a beef @entity291 Brazilian breed known for its @entity17246 and desirable characteristics for tropical conditions. However, this is a newly formed breed and few studies have been conducted regarding genetic parameters and genetic trends for its reproductive traits. The objective of the present study was to estimate the genetic parameters, genetic trends, and relative selection efficiency for weaning weight adjusted to 210 d of age (W210), age at first calving (AFC), average calving interval (ACI), first calving interval (CI1), and @entity409 ( @entity409 ) among Tabapu   beef @entity291 . Pedigree data on 15,241 Tabapu   animals born between 1958 and 2011 and phenotype records from 7,340 @entity291 born between 1970 and 2011 were supplied by the National Association of Breeders and Researchers (Associa    o Nacional de Criadores e Pesquisadores). Analysis through the least squares method assisted in defining the fixed effects that were considered within the models. The estimates for the genetic parameters were obtained through the REML, using a multitrait animal model. The likelihood ratio test applied for W210 was significant ( < 0.05) for the inclusion of maternal additive genetic and permanent environmental effects in the model. Genetic trends were calculated through linear regression of the EBV of the animals, according to the year of birth. The heritability estimates obtained ranged from 0.04    0.03 for CI1 to 0.25    0.05 for W210. The genetic correlations ranged from 0.004    0.19 for W210-AFC and 0.93    0.12 for ACI-CI1. The genetic trend was significant ( < 0.05) and favorable for CI1 and the maternal genetic effect of W210 and was significant ( < 0.05) and unfavorable for AFC, ACI, and @entity409 . The @entity409 could be used in the selection index to assist the breeding goal of improved productive and reproductive performance. The genetic trends indicated small and unfavorable genetic changes for AFC, ACI, and @entity409 in light of the recent implementation of a genetic breeding program for this breed.

title: Estimates of genetic parameters and genetic trends for reproductive traits and weaning weight in Tabapu   XXXX .

entities_list: @entity409 :: ('MESH:D008107', 'Disease') :: ['accumulated productivity', 'ACP']

entities_list: @entity17246 :: ('MESH:C538542', 'Disease') :: ['sexual precocity']

answer: @entity291 :: (9913,Species) :: ['cattle']


abstract: BACKGROUND: The @entity6309 challenge test correlates well with a @entity1 's peak diurnal intraocular pressure (IOP) measurement. We aimed to investigate the effect that a functioning trabeculectomy has on the @entity6309 challenge test. DESIGN: Non-randomized prospective clinical trial evaluating a diagnostic test. @entity1 : Thirteen @entity1 were recruited through @entity726 clinics at the Flinders Medical Centre. Of these, seven required surgical management with trabeculectomy surgery, whilst the remainder were managed medically. METHODS: @entity1 underwent IOP measurement, and then two drops of @entity6309 2% solution were instilled into the study eye of each @entity1 . After 45   min, IOP was reassesed. A positive challenge test was considered to be a rise in IOP of greater than 3   mmHg. Changes from baseline were determined and compared between groups. Twelve months later, this test was then repeated in all @entity1 . MAIN OUTCOME MEASURE: Change in IOP after @entity6309 challenge. RESULTS: Following the @entity6309 challenge, IOP increased by 9.2   mmHg (SD 2.8) (100% positive) for medically managed @entity1 and 7.2   mmHg (SD 2.0) (100% positive) for surgically managed @entity1 (P   =   0.18). The surgically managed group then underwent trabeculectomy surgery. Twelve months later, the @entity6309 challenge was repeated. Following the repeat @entity6309 challenge, IOP increased by 7.2   mmHg (SD 2.3) for medically managed @entity1 and 0.3   mmHg (SD 1.3) for surgically managed @entity1 (P   <   0.0001). The medically managed group remained 100% positive, whilst the surgically manage group became 0% positive (Fisher Exact P   =   0.044). CONCLUSIONS: A @entity726 @entity1 with a positive @entity6309 challenge will show a negative challenge result when re-tested following trabeculectomy surgery.

title: XXXX challenge testing becomes negative following successful trabeculectomy surgery.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient', 'PARTICIPANTS']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

entities_list: @entity6309 :: ('MESH:C023487', 'Chemical') :: ['ibopamine', 'Ibopamine']

answer: @entity6309 :: (MESH:C023487,Chemical) :: ['Ibopamine']


abstract: Vocal @entity717 are increasingly recognized in @entity1 with @entity746 ( @entity746 ). We describe a @entity1 with limb-onset @entity746 who developed @entity3746 . A 74-year-old Japanese male consulted our clinic with a 6-month history of @entity425 in both arms. His family history was unremarkable. There were @entity2901 and mild @entity194 and both arms. In the legs, muscle strength was almost normal but widespread @entity2901 were present. All tendon reflexes were hypoactive and pathological reflexes were absent. Thereafter, he developed @entity425 and showed increased eating time. Babinski sign was positive bilaterally at this stage. The forced vital capacity dropped from 90% at the initial evaluation to 62% of the predicted value 14 months later. Two years after disease onset, the @entity1 developed @entity1174 with hoarseness and had difficulty clearing his throat of phlegm. Laryngoscopy demonstrated severe @entity3746 on both sides, particularly in the abductor muscles possibly leading to obstruction. Tracheotomy was performed because of the risk that the @entity1 could @entity1224 to @entity204 . A review of the literature suggests that severe @entity602 could be a prelude to @entity944 in @entity746 . Follow up by laryngoscopic examination is necessary.

title: [A case of @entity746 with bilateral XXXX necessitating tracheotomy].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity602 :: ('MESH:D013118', 'Disease') :: ['impairment of vocal cord abduction']

entities_list: @entity425 :: ('MESH:D018908', 'Disease') :: ['weakness of the legs', 'weakness']

entities_list: @entity2901 :: ('MESH:D005207', 'Disease') :: ['fasciculations']

entities_list: @entity1174 :: ('MESH:D011015', 'Disease') :: ['aspiration pneumonia']

entities_list: @entity194 :: ('MESH:D001284', 'Disease') :: ['atrophy of the tongue']

entities_list: @entity746 :: ('MESH:D000690', 'Disease') :: ['ALS', 'amyotrophic lateral sclerosis']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['cord movement disorders']

entities_list: @entity3746 :: ('MESH:D014826', 'Disease') :: ['vocal cord paresis', 'vocal cord paralysis']

answer: @entity3746 :: (MESH:D014826,Disease) :: ['vocal cord paralysis']


abstract: BACKGROUND: The @entity3 of @entity263 to bone is associated with a substantial increase in bone matrix turnover. Matrix metalloproteinases (MMPs) play roles in both normal bone remodeling and invasion and @entity3 of @entity263 . This study was designed to determine the role of MMP activity in @entity263 that has metastasized to bone. METHODS: Single @entity1 fetal bone fragments were implanted subcutaneously in immunodeficient @entity19 . Four weeks later, @entity5049 @entity1 @entity263 cells were injected directly into some of the implants, and daily treatment was begun with batimastat (a broad-spectrum MMP inhibitor). There were six @entity19 (i.e., six implants) in each of four experimental arms: bone alone with and without batimastat and bone injected with @entity5049 cells with and without batimastat. Bone implants were harvested after 14 days of treatment and analyzed for MMP expression, bone histomorphometry, osteoclast counts, blood vessel density, and @entity5 cell proliferation and apoptosis. Complementary data were obtained from bone biopsy samples from @entity1 and a bone organ coculture system. All statistical tests were two-sided. RESULTS: MMPs were detected in @entity5 and stromal cells of clinical specimens and experimental bone implants. In vivo, MMP inhibition reduced the number of osteoclasts per millimeter in @entity5049 -injected implants-from 8.2 (95% confidence interval [CI] = 7.9 to 8.5) to 3.0 (95% CI = 2.3 to 3.7) (P =.006). In addition, it prevented degradation of marrow trabeculae within the bone implants (cross-sectional area of implant occupied by mineralized trabeculae: untreated implant = 29.1% [95% CI = 27.1% to 31.1%], @entity5049 -injected implant = 14.0% [95% CI = 10.9% to 17.1%] [P =.005 versus untreated], and batimastat-treated @entity5049 -injected implant = 27.2% [95% CI = 22.4% to 32.0%] [P =.03 versus @entity5049 injected alone]). MMP inhibition reduced proliferating @entity5 cells from 20.8% (95% CI = 19.9% to 21.7%) to 7.4% (95% CI = 5.2% to 9.6%) (P =.006), without affecting angiogenesis or apoptosis. In vitro, MMP inhibition had no toxic effect on @entity5049 cells but prevented calcium release from bone fragments cocultured with @entity5049 cells. CONCLUSIONS: MMP activity appears to play an important role in bone matrix turnover when @entity263 cells are present in bone. Bone matrix turnover and metastatic @entity5 growth appear to be involved in a mutually supportive cycle that is disrupted by MMP inhibition.

title: Matrix metalloproteinase activity, bone matrix turnover, and @entity5 cell proliferation in XXXX bone @entity3 .

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostate cancer']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

answer: @entity263 :: (MESH:D011471,Disease) :: ['prostate cancer']


abstract: Dendritic cells (DC) are the initiators of immune responses and are present in most tissues in vivo. To generate myeloid DC from monocytes (MoDC) in vitro the necessary cytokines are @entity2841 ( @entity2841 ) and @entity3646 ( @entity3646 ). Using degenerated primers delineated from other species and rapid amplification of cDNA ends reverse transcription-polymerase chain reaction (RACE RT-PCR), the cDNA of @entity1641 (eq.) @entity2841 was cloned and found to have a point deletion at the 3'-end of eq. @entity2841 , resulting in a 24- @entity377 extended open reading frame not described in any species thus far. For differentiating eq.MoDC, monocytes were stimulated with eq. @entity2841 and eq. @entity3646 . The eq.MoDC was analysed by both light and electron microscopy and by flow cytometry and mixed lymphocyte reaction. The eq.MoDC obtained had the typical morphology and function of DC, including the ability to stimulate allogeneic T cells in a mixed lymphocyte reaction. In contrast to the @entity1 system, however, monocytes had to be differentiated for 6-7 days before immature DC were obtained. Our data also indicate that lipopolysaccharide or poly(I:C) alone are not sufficient to confer the full phenotypic transition into mature DC. Thus our study contributes to understanding the heterogeneity of immunity and adds important information on the @entity1641 immune system, which is clearly distinct from those of @entity19 or @entity1 .

title: Monocyte-derived dendritic cells from @entity1641 differ from dendritic cells of @entity1 and XXXX .

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity2841 :: ('1437', 'Gene') :: ['granulocyte-macrophage colony-stimulating factor', 'GM-CSF']

answer: @entity19 :: (10090,Species) :: ['mice']


abstract: PURPOSE: The objective of the study was to describe the occurrence of @entity3136 and @entity358 in @entity1 with @entity1358 ( @entity1358 ) treated with second-line @entity2239 in a real-world setting. METHODS: This multicenter, prospective, observational study was conducted in France by physicians with experience of treatment of @entity1 with @entity1358 . @entity1 aged >= 18  years who received @entity2239 after first-line antivascular endothelial growth factor ( @entity7 ) therapy were included in the study. The primary safety assessments were occurrence of @entity3136 (in terms of severity, event dates, and therapeutic management) and noninfectious @entity55 (in terms of detection methodology, severity, event dates, and therapeutic management). RESULTS: Between September 2010 and August 2012, 284 @entity1 were enrolled at 77 centers, of whom, 274 received @entity2239 therapy. Most @entity1 had @entity1358 of clear cell histology (88%), and most of them (84%) received first-line @entity2240 . In total, 40% of @entity1 experienced treatment-related @entity3136 , and 15% of @entity1 experienced @entity358 . Most of them had a single episode. The incidence of grade 3 @entity3136 and @entity358 were 8 and 3%, respectively. Mean time to the first episode was 27  days for @entity3136 and 72  days for @entity358 from treatment initiation. @entity3136 and @entity358 resulted in treatment discontinuations in 2 and 7% of @entity1 , respectively. The primary first-episode treatment was mouthwash (86%) for @entity3136 and corticosteroids (65%) for @entity358 . CONCLUSIONS: This study confirms that @entity3136 and @entity358 are commonly associated with @entity2239 use. Both adverse events were rarely severe and were managed easily and efficiently.

title: A prospective observational study on the evaluation of @entity2239 -related adverse events in XXXX after first-line anti- @entity7 therapy: the AFINITE study in France.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity3136 :: ('MESH:D013280', 'Disease') :: ['stomatitis', 'Stomatitis']

entities_list: @entity2240 :: ('MESH:C473478', 'Chemical') :: ['sunitinib']

entities_list: @entity55 :: ('MESH:D011014', 'Disease') :: ['pneumonitis']

entities_list: @entity2239 :: ('MESH:C107135', 'Chemical') :: ['everolimus']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['mRCC', 'metastatic renal cell carcinoma']

entities_list: @entity358 :: ('MESH:D008171', 'Disease') :: ['noninfectious lung disease']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['metastatic renal cell carcinoma']


abstract: BACKGROUND, AIMS: Oral @entity597 -reducing bacteria are involved in several clinical categories of @entity2521 . The aim of this cross-sectional study was to compare the presence of @entity597 -reducing bacteria (SRB) with other putative pathogens including spirochetes, @entity3841 , @entity3289 , @entity2523 , and @entity14148 in periodontal lesions. METHOD: Periodontal SRB were detected by enrichment culture and compared with a microscopic spirochete count (n=168). Species-specific oligonucleotide probes directed against the 16S rRNA were employed to determine the presence of A. actinomycetemcomitans, @entity2523 , @entity3289 , and @entity14148 (n=55). RESULTS: A significant positive correlation was observed between the presence of SRB and the proportions of spirochetes in @entity527 , although the 2 bacterial groups also occurred separately. SRB tended to be negatively correlated with the presence of A. actinomycetemcomitans. In contrast, all pockets with SRB harbored either @entity14148 , or both @entity14148 and @entity3289 (12/14) before therapy. Interestingly, the combination of SRB with @entity2523 occurred in 32% of the periodontal pockets before treatment. After initial periodontal therapy, the prevalence of this combination was reduced to 2% of the sites, and to 25% of the sites in recall @entity1 . CONCLUSION: The presence of SRB was positively correlated with @entity14148 , @entity3289 , and @entity2523 in periodontal lesions. These suspected pathogens form a complex strongly associated with destructive @entity2521 .

title: XXXX -reducing bacteria in relation with other potential periodontal pathogens.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity527 :: ('MESH:D058225', 'Disease') :: ['subgingival plaque']

entities_list: @entity14148 :: ('158', 'Species') :: ['T. denticola', 'Treponema denticola']

entities_list: @entity597 :: ('CHEBI:16189', 'Chemical') :: ['sulfate']

entities_list: @entity3289 :: ('28112', 'Species') :: ['B. forsythus', 'Bacteroides forsythus']

entities_list: @entity3841 :: ('714', 'Species') :: ['Actinobacillus actinomycetemcomitans']

entities_list: @entity2521 :: ('MESH:D010518', 'Disease') :: ['periodontitis']

entities_list: @entity2523 :: ('837', 'Species') :: ['Porphyromonas gingivalis', 'P. gingivalis']

answer: @entity597 :: (CHEBI:16189,Chemical) :: ['Sulfate']


abstract: Two experiments were conducted at the Delta Research and Extension Center in Stoneville, MS, during 2011 and 2012 to determine the impact of water management practices on the efficacy of insecticidal seed treatments targeting @entity579 water weevil, Lissorhoptrus oryzophilus Kuschel. Larval densities and yield were compared for plots treated with labeled rates of @entity14155 , @entity39055 , and @entity32711 and an untreated control. In the first experiment, plots were subjected to flood initiated at 6 and 8 wk after planting. Seed treatments significantly reduced larval densities with the 8-wk flood timing, but not the 6-wk flood timing. Overall, the treated plots yielded higher than the control plots. In the second experiment, the impact of multiple flushes on the efficacy of insecticidal seed treatments was evaluated. Plots were subjected to zero, one, or two flushes with water. All seed treatments reduced larval densities compared with the untreated control. Significantly fewer larvae were observed in plots that received one or two flushes compared with plots that did not receive a flush. All seed treatments resulted in higher yields compared to the untreated control in the zero and one flush treatments. When two flushes were applied, yield from the @entity14155 and @entity32711 treated plots was not significantly different from those of the control plots, while the @entity39055 treated plots yielded significantly higher than the control. These data suggest that time from planting to flood did not impact the efficacy of seed treatments, but multiple flushes reduced the efficacy of @entity14155 and @entity32711 .

title: Impact of Water Management on Efficacy of Insecticide Seed Treatments Against @entity579 Water Weevil (Coleoptera: Curculionidae) in Mississippi XXXX .

entities_list: @entity14155 :: ('MESH:C416660', 'Chemical') :: ['thiamethoxam']

entities_list: @entity32711 :: ('MESH:C480342', 'Chemical') :: ['clothianidin']

entities_list: @entity39055 :: ('MESH:C517733', 'Chemical') :: ['chlorantraniliprole']

answer: @entity579 :: (4530,Species) :: ['Rice']


abstract: BACKGROUND: A low @entity14951 ( @entity14282 ) serum concentration at @entity320 diagnosis might be associated with worse survival. We prospectively studied the prognostic value of @entity14282 at diagnosis and during follow-up. METHODS: MelanCohort is a cohort of invasive @entity320 patients. Serum @entity14282 was measured by mass spectrometry and standardized on month of blood drawn, age, sex, and body mass index (BMI). Role of @entity14282 levels and risk of relapse was analyzed in a Cox proportional hazards model adjusting for age, sex, BMI, and American Joint Committee on Cancer (AJCC) stage. All statistical tests were two-sided. RESULTS: One thousand one hundred seventy-one @entity1 were included. @entity14282 levels at diagnosis (median = 49.0 nmol/L) were inversely correlated with prognostic factors such as AJCC stage (P < .001 Kruskal-Wallis), Breslow's thickness (P < .001 Spearman correlation), and @entity1066 (P < .001 Kruskal-Wallis), but not with risk of relapse. Changes in @entity14282 levels during follow-up were associated with worse prognosis: With a third quartile Q3 of average change per year (-0.30 to 4.60 nmol/L/Y) used as reference, hazard ratios for the first, second, and fourth quarters were 1.94 (95% confidence interval [CI] = 1.36 to 2.76), 1.23 (95% CI = 0.85 to 1.78), and 1.61 (95% CI = 1.14 to 2.28), respectively. In sensitivity analyses, no changes were observed either by AJCC stage, number of @entity14282 measures performed, or by @entity14282 level at baseline. No evidence of reverse causation was identified. Analyses performed on overall survival yielded similar results. CONCLUSIONS: We show that @entity14282 variation during follow-up is an independent @entity320 prognostic marker, but not its level at diagnosis. Previously reported associations between low @entity14282 level at diagnosis and poor prognosis seem to be due to insufficient adjustment for prognostic factors.

title: Prognostic Value of XXXX Levels at Diagnosis and During Follow-up in @entity320 @entity1 .

entities_list: @entity1066 :: ('MESH:D014456', 'Disease') :: ['ulceration']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

entities_list: @entity14951 :: ('MESH:D002112', 'Chemical') :: ['25-hydroxyvitamin D3']

answer: @entity14951 :: (MESH:D002112,Chemical) :: ['25-hydroxyvitamin D3']


abstract: AIM: This study was designed to answer the question of whether multifocal steady-state pattern-reversal electroretinography (ERG) is capable of detecting @entity227 . METHOD: Sixteen @entity1 (28 eyes) and ten normal subjects (20 eyes) were examined. Multifocal pattern ERGs were recorded with the RETIscan system and DTL electrodes. We stimulated with a steady-state checkerboard pattern reversal (three reversals during 171 ms sweep length, congruent with 17.5 reversals/s). The multifocal pattern ERG amplitudes were evaluated using discrete Fourier transformation (DFT) across three reversals. In cases of advanced @entity726 , the DFT-calculated amplitudes were combined in hemispheres and checked for correlations with corresponding @entity227 . In all binocularly examined @entity1 , side comparisons ("worse" eye vs "better" eye), and interindividual comparisons ( @entity726 vs normal) were carried out. RESULTS: In interindividual comparisons and interocular side comparisons, significant @entity735 were seen in the foveal records. No topographical correlation between multifocal pattern ERG amplitudes and @entity227 could be found. CONCLUSIONS: In @entity227 , multifocal steady-state pattern-reversal ERG using the present stimulation was significantly reduced in its foveal records but seems to be incapable of detecting them topographically.

title: [Multifocal steady-state pattern-reversal electroretinography in @entity726 XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'persons']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['amplitude reductions of the "worse" eyes']

entities_list: @entity227 :: ('MESH:D014786', 'Disease') :: ['visual field defects', 'glaucomatous visual field defects']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['glaucoma']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: OBJECTIVE: To generate phage-displayed anti-idiotypic antibody single chain variable fragments (anti-Id ScFv) MG7 to monoclonal antibody directed against @entity356 so as to lay a foundation for developing anti-Id ScFv vaccine of the @entity5 . METHODS: Balb/c @entity19 were immunized i.p. with purified MG7 monoclonal antibody conjugated with keyhole limpet hemocyanin. mRNA was isolated from the spleens of immunized @entity19 . Heavy and light chain genes (VH and VL) of antibody were amplified separately and assembled into ScFv genes with a specially constructed linker DNA by RT-PCR. The ScFv genes were ligated into the phagemid vector pCANTAB5E and the ligated sample was transformed into competent @entity526 TG1. The transformed cells were infected with M13KO7 helper phage to yield recombinant phage, which displayed ScFv fragments as a fusion with gene 3 protein on the tips of M13 phage. After four rounds of panning with monoclonal antibody MG7, the MG7-positive clones were selected with the enzyme-linked immunosorbent assay (ELISA) from the enriched phages. The types of the anti-Id ScFv displayed on the selected phage clones were primarily identified by competition ELISA. RESULTS: The VH, VL and ScFv DNAs were about 340, 320 and 750 bp respectively. Twenty-four MG7-positive clones were selected from 40 enriched phage clones. Five of the 24 clones displayed beta or gamma type anti-Id ScFv. CONCLUSION: The anti-Id ScFv frangments to MG7 monoclonal antibody can be successfully selected by recombinant phage antibody technique, which paves a way for the study of prevention and cure of @entity356 using anti-Id ScFv.

title: [Production of phage-displayed anti-idiotypic antibody single chain variable fragments to MG7 monoclonal antibody directed against XXXX ].

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric carcinoma']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric carcinoma']


abstract: BACKGROUND/AIMS: Thrombolysis for @entity583 is more effective in smokers. Our aim was to determine whether smokers treated by intravenous (i.v.) rt-PA for @entity2806 have better outcomes. METHOD: Comparison of smokers and non-smokers for baseline characteristics and month-3 outcome in @entity1 treated by i.v. rt-PA for @entity2806 in Lille, France, and Belgrade, Serbia. The primary outcome was a modified Rankin scale (mRS) 0-1 or similar to the pre- @entity64 mRS. Secondary outcomes were an mRS 0-2 and @entity204 . RESULTS: We included 459 @entity1 (255 @entity1 ; median age 65 years, interquartile range 52-76; 135 smokers). Smokers were younger (median 53 vs. 70 years, p < 0.0001) and had less severe @entity64 (median NIHSS 10 vs. 14, p < 0.0001). At month 3, they were more likely to have an mRS 0-1 [odds ratio (OR) 1.75; 95% confidence interval (CI) 1.17-2.62], or an mRS 0-2 (OR 2.90; 95% CI 1.86-4.52) and less likely to be dead (OR 0.28; 95% CI 0.13-0.61). Smoking was not independently associated with outcome after adjustment for case mix [adjusted OR ((adj)OR) 0.86; 95% CI 0.52-1.43]. CONCLUSION: Smoking does not independently influence the outcome in @entity1 treated by rt-PA for @entity2806 . The better outcome in smokers is the consequence of differences in case mix.

title: Influence of differences in case mix on the better outcome of smokers after intravenous thrombolysis for XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['men', 'patients']

entities_list: @entity64 :: ('MESH:D020521', 'Disease') :: ['strokes', 'stroke']

entities_list: @entity2806 :: ('MESH:D002545', 'Disease') :: ['cerebral ischemia', 'acute cerebral ischemia']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction']

answer: @entity2806 :: (MESH:D002545,Disease) :: ['acute cerebral ischemia']


abstract: OBJECTIVES: This study sought to compare the impact of primary coronary angioplasty and thrombolytic therapy for @entity583 ( @entity583 ) on 1-month @entity1188 size and microvascular perfusion. BACKGROUND: The effect of the reperfusion strategies of primary coronary angioplasty and thrombolytic therapy on microvascular integrity still remains to be determined. METHODS: Sixty-two consecutive @entity1 with a first @entity583 , undergoing intravenous @entity3479 ( @entity3479 ) therapy (32 @entity1 , Group I) or primary angioplasty (30 @entity1 , Group II), were studied. Only @entity1 with 1-month Thrombolysis in @entity583 (TIMI) flow grade 2 or 3 were selected for the study. @entity1 in whom primary angioplasty was unsuccessful or those with clinical evidence of failed reperfusion were excluded. Microvascular perfusion was assessed at 1 month by intracoronary injection of sonicated microbubbles. Contrast score index (CSI) and wall motion score index (WMSI) were derived using qualitative methods. RESULTS: At baseline there were no significant differences between groups for age, risk factors, time to hospital presentation, Killip class on admission, prevalence of multivessel disease or anterior @entity1188 site, @entity1188 area extension before reperfusion, peak @entity908 kinase levels and postinfarction treatment. Conversely, significant differences between groups were found at follow-up for percent residual @entity1188 (70 +/- 12 vs 36 +/- 14 [mean +/- SD], p = 0.0001), CSI (1.02 +/- 0.4 vs. 1.49 +/- 0.5, p = 0.0003) and WMSI (1.67 +/- 0.3 vs. 1.45 +/- 0.3, p = 0.015). In particular, in the subset of @entity1 with TIMI grade 3 flow, a perfusion defect occurred in one or more segments subtended by the IRA in 72% of Group I versus 31% of Group II @entity1 (p < 0.00001) and in 27% of Group I versus 8% of Group II segments (p < 0.00001). CONCLUSIONS: The present study shows, in a highly selected cohort with successful IRA recanalization, that primary angioplasty is more effective than thrombolysis in preserving microvascular flow and preventing extension of @entity296 at 1-month after @entity583 .

title: XXXX therapy versus primary coronary angioplasty: impact on myocardial tissue perfusion and regional function 1 month after uncomplicated @entity583 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity296 :: ('MESH:D009202', 'Disease') :: ['myocardial damage']

entities_list: @entity908 :: ('MESH:D003401', 'Chemical') :: ['creatine']

entities_list: @entity1188 :: ('MESH:D007238', 'Disease') :: ['infarct related-artery (IRA) stenosis', 'infarct']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['AMI', 'Myocardial Infarction', 'acute myocardial infarction']

entities_list: @entity3479 :: ('5327', 'Gene') :: ['tissue-type plasminogen activator', 't-PA']

answer: @entity3479 :: (5327,Gene) :: ['Tissue-type plasminogen activator']


abstract: ABSTRACT Purpose: The acute phase protein, a1-acid glycoprotein, is expressed in the lung, and influences endothelial cell function. We asked whether it might regulate angiogenesis in @entity1 lung microvascular endothelia. MATERIALS AND METHODS: a1-acid glycoprotein was isolated from human serum by HPLC ion exchange chromatography. Its effects on endothelial cell functions including capillary-like tube formation on Matrigel, migration in a wounding assay, chemotaxis in a modified Boyden chamber, adhesion, and transendothelial flux of the permeability tracer, @entity3209 -albumin, were tested. RESULTS: a1-acid glycoprotein dose-dependently inhibited capillary-like tube formation without loss of cell viability. At >= 0.50  mg/mL, it inhibited tube formation >70%, and at 0.75  mg/mL, >97%. a1-acid glycoprotein dose- and time-dependently restrained EC migration into a wound as early as 2  hours, and in washout studies, did so reversibly. It was inhibitory against @entity7 and @entity540 -driven migration but failed to inhibit chemotactic responsiveness. When a1-acid glycoprotein was added to preformed tubes, it provoked their almost immediate disassembly. As early as 15 minutes, it induced @entity5274 without endothelial cell-cell disruption. It exerted a biphasic effect on cell adhesion to the Matrigel substrate. At lower concentrations (0.05-0.25  mg/mL), it increased cell adhesion, whereas at higher concentrations (>= 0.75  mg/mL) decreased adhesion. In contrast, it had no effect on transendothelial (14)C-albumin flux. CONCLUSION: a1-acid glycoprotein, at concentrations found under physiological conditions, rapidly inhibits endothelial cell capillary-like tube formation that may be explained through diminished cell adhesion to the underlying matrix and/or reversibly decreased cell migration.

title: a1-Acid glycoprotein disrupts capillary-like tube formation of XXXX lung microvascular endothelia.

entities_list: @entity7 :: ('7422', 'Gene') :: ['vascular endothelial growth factor-A']

entities_list: @entity540 :: ('2247', 'Gene') :: ['fibroblast growth factor-2']

entities_list: @entity5274 :: ('MESH:D005184', 'Disease') :: ['tube network collapse']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: OBJECTIVE: To evaluate the long-term results of @entity1 surgically treated for metastatic @entity1358 ( @entity1358 ) with a unique pancreatic secondary localization to assess the importance of radical treatment in this rare group of @entity1 . @entity1 AND METHODS: This is a retrospective monocentric study including 20 surgically treated @entity1 between 1997 and 2012 for a unique pancreatic @entity3 of a @entity1358 . The main objective was to evaluate the outcome after surgical resection. RESULTS: Twenty @entity1 were followed up for a @entity1358 . The M/F ratio was 1.2. The average age of onset of @entity703 was 57.05    7.78  years. Two @entity1 who had synchronous pancreatic @entity3 and 18 @entity1 who had metachronous @entity3 appeared after an average of 130    59  months (24-240 months). The average size of the metastases was 20    11.6  mm. @entity788 was unique in all @entity1 , with 35% of @entity1 having multiple lesions of the pancreas. All @entity1 underwent a pancreatic resection of @entity3 . Histologic examination confirmed the location of a secondary @entity1358 in all @entity1 . Median follow-up after pancreatectomy was 69  months (1-150 months). Disease-free survival at 2  years was 60%. Overall survival rates at 2 and 4  years were 79% and 72%, respectively. There was no difference found between @entity1 with multiple and unique pancreatic metastases in overall survival. CONCLUSION: Unique pancreatic @entity3 of @entity1358 is rare. The literature on this subject is limited. Surgical resection might be an option and can be associated with long-term disease-free intervals in highly selected @entity1 .

title: @entity788 from XXXX : outcome of an aggressive approach.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity788 :: ('MESH:D010190', 'Disease') :: ['Pancreatic metastasis']

entities_list: @entity1358 :: ('MESH:D002292', 'Disease') :: ['CCRCC', 'clear cell renal cell carcinoma']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity703 :: ('MESH:D007680', 'Disease') :: ['kidney cancer']

answer: @entity1358 :: (MESH:D002292,Disease) :: ['clear cell renal cell carcinoma']


abstract: PURPOSE: To determine the genomic organization of the @entity3392 @entity68636 gene and to evaluate if mutations in @entity68636 are responsible for the @entity2000 phenotype in the @entity3392 ( @entity3392 ) mutants niezerka (nie(m743)) and mikre oko (mok(m632)). METHODS: Overlapping fragments were PCR amplified from genomic DNA isolated from homozygous mutant embryos and wild-type siblings (sibs). Amplicons were sequenced and sequence data assembled into contigs. Genomic organization was determined by alignment of contigs with published cDNA sequences and @entity3392 genomic sequence from Sanger and Ensembl databases. Linkage analysis used DNA from mapping panels of single homozygous mutant animals with mixed genetic backgrounds. RESULTS: The analysis indicated that the @entity3392 @entity68636 gene consisted of three exons and 2 introns, and spans 3.8 kb of genomic DNA. The splice junctions were all located within the coding region. Highly repetitive sequences present in non-coding regions of @entity68636 and extended tetra- @entity377 repeats in intronic regions were associated with sequence variation between different strains. Homozygous mok(m632) or nie(m743) mutants and their respective wild-type sibs, showed identical patterns of heterozygosity and sequence variations within each line. No mutation in @entity68636 were identified in homozygous mok(m632) or nie(m743). Consistent with the absence of identified mutations, linkage analysis excluded linkage of the mutant phenotypes to @entity68636 . CONCLUSIONS: Despite the presence of sequence variations in their respective genetic backgrounds, within each line the sequence of @entity68636 was identical. Consistent with the absence of mutations, further analysis excluded linkage of the mutant phenotypes to @entity68636 . Analysis is in progress to map these loci and identify the genes responsible for the @entity2000 phenotype in these mutant lines.

title: Genomic organization of @entity3392 cone-rod homeobox gene and exclusion as a candidate gene for XXXX in niezerka and mikre oko.

entities_list: @entity2000 :: ('MESH:D012162', 'Disease') :: ['retinal degeneration']

entities_list: @entity377 :: ('CHEBI:36976', 'Chemical') :: ['nucleotide']

entities_list: @entity3392 :: ('7955', 'Species') :: ['zebrafish', 'Danio rerio']

answer: @entity2000 :: (MESH:D012162,Disease) :: ['retinal degeneration']


abstract: UNASSIGNED: OBJECT The study aim was to examine the effect of gradually reducing the opening pressure on symptoms and signs in the shunt treatment of @entity5083 ( @entity5083 ). METHODS In this prospective double-blinded, randomized, controlled, double-center study on @entity1 with @entity5083 , a ventriculoperitoneal shunt with an adjustable Codman Medos Valve was implanted in 68 @entity1 randomized into 2 groups. In 1 group (the 20-4 group) the valve setting was initially set to 20 cm @entity4358 and gradually reduced to 4 cm @entity4358 over the course of the 6-month study period. In the other group (the 12 group), the valve was kept at a medium level of 12 cm @entity4358 during the whole study period. All @entity1 were clinically evaluated using 4 tests preoperatively as well as postoperatively at 1, 2, 3, 4, and 6 months. The test scores between the 2 groups (20-4 and 12) were compared for each clinical evaluation. RESULTS Fifty-five @entity1 (81%) were able to complete the study. There were no significant differences between the 2 groups (20-4 and 12) preoperatively or at any time postoperatively. Both groups exhibited significant clinical improvement after shunt insertion at all valve settings compared with the preoperative score, with the greatest improvement observed at the first postoperative evaluation. The clinical improvement was significant within the first 3 months, and thereafter no significant improvement was seen in either group. CONCLUSIONS Gradual reduction of the valve setting from 20 to 4 cm @entity4358 did not improve outcome compared with a fixed valve setting of 12 cm @entity4358 . Improvement after shunt surgery in @entity5083 @entity1 was evident within 3 months, irrespective of valve setting.

title: A double-blind randomized trial on the clinical effect of different shunt valve settings in XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity5083 :: ('MESH:D006850', 'Disease') :: ['idiopathic normal pressure hydrocephalus', 'iNPH']

answer: @entity5083 :: (MESH:D006850,Disease) :: ['idiopathic normal pressure hydrocephalus']


abstract: BACKGROUND: @entity3965 @entity311 is an important public health issue in the Amazon region, and it accounts for approximately 84  % of cases of the disease. Migration across the border between Brazil and French Guiana contributes to the maintenance of the disease. The aim of this study was to evaluate the therapeutic and parasitological responses of @entity1 with @entity3965 @entity311 treated with @entity503 and @entity12433 in the socio-environmental context of cross-border interactions between Brazil and French Guiana. The factors controlled were diagnostic agreement, adherence, adjustment of @entity12433 doses for @entity1 weight, and quality of the drugs used. METHODS: A prospective study was conducted in 2011 with 103 individuals aged 10-60  years with a positive diagnosis of @entity3965 treated with @entity503 (10  mg base/kg on the first day, followed by 7.5  mg/kg on the second and third days) and @entity12433 for 7  days, who were followed for 28  days. The @entity12433 doses were adjusted for the @entity1 ' weight. A number of factors were determined: epidemiological characteristics, origin of @entity1 , signs and symptoms, initial parasitaemia and parasitaemia clearance time, blood concentrations of @entity503 and @entity12433 , quality of anti-malarial drugs and diagnostic agreement. RESULTS: Ninety-five @entity1 were followed for 28  days. There was a 100  % agreement in microscopic diagnosis between field laboratory and reference centre. The adhesion to the treatment was 100  %. Of these @entity1 , 32.6  % received a weight-adjusted dose of @entity12433 . The @entity503 and @entity12433 tablets were consistent with the optimal quality limits for @entity1 consumption. The investigated @entity1 achieved optimal blood exposure to anti-malarial drugs. The parasitological and therapeutic response was adequate in 99.0  % of cases. CONCLUSIONS: In the municipality of Oiapoque, the therapeutic regime used for the treatment of @entity3965 @entity311 using @entity503 combined with @entity12433 remains effective, when external factors are controlled, such as the quality of anti-malarial drugs, the adhesion to the treatment prescribed, the correct diagnostic and the adjustment of @entity12433 dose for @entity1 body weight.

title: Efficacy in the treatment of XXXX by @entity3965 in Oiapoque, Brazil, on the border with French Guiana: the importance of control over external factors.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'human', 'patient']

entities_list: @entity3965 :: ('5855', 'Species') :: ['P. vivax', 'Plasmodium vivax']

entities_list: @entity12433 :: ('MESH:D011319', 'Chemical') :: ['primaquine']

entities_list: @entity503 :: ('MESH:D002738', 'Chemical') :: ['chloroquine']

answer: @entity311 :: (MESH:D008288,Disease) :: ['malaria']


abstract: BACKGROUND: Alemtuzumab is a humanized monoclonal antibody approved in several countries for treatment of @entity3780 ( @entity3780 ). This report summarizes the experience with infusion-associated reactions (IARs) in two phase 3 trials of alemtuzumab in @entity3780 and examines skilled nursing interventions in IAR prevention and management. METHODS: In the Comparison of Alemtuzumab and Rebif(  ) Efficacy in @entity15 (CARE-MS) studies, @entity1 with @entity3780 (treatment naive [CARE-MS I] or with inadequate response [defined as at least one relapse] to previous therapy [CARE-MS II]) received intravenous infusions of alemtuzumab 12 mg/day on 5 consecutive days at baseline and on 3 consecutive days 12 months later. @entity1 were monitored for IARs during and after each infusion. An IAR was defined as any adverse event occurring during any infusion or within 24 hours after infusion. RESULTS: The IARs affected 90.1% of @entity1 receiving alemtuzumab. The most common IARs were @entity10 , @entity1910 , @entity221 , @entity390 , and @entity1671 ; most were mild to moderate in severity. Management of IARs consisted of infusion interruption or rate reduction, pharmacologic therapies, and continual @entity1 education and support. Medication administration before and during alemtuzumab infusion reduced IAR severity. Forty-five of 972 alemtuzumab-treated @entity1 (4.6%) required interruption of the first treatment course (ie, infusions did not occur on consecutive days); of these, 24 (53.3%) were still able to complete the first and second full treatment courses. CONCLUSIONS: Nurses played an invaluable role in the detection and management of IARs in the CARE-MS studies. Best practices for management of IARs associated with alemtuzumab include @entity1 and caregiver education, medication to lessen IAR severity, infusion monitoring, and discharge planning.

title: Prevention and Management of Infusion-Associated Reactions in the Comparison of Alemtuzumab and Rebif(  ) Efficacy in XXXX (CARE-MS) Program.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity3780 :: ('MESH:D020529', 'Disease') :: ['relapsing-remitting multiple sclerosis', 'RRMS']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity15 :: ('MESH:D009103', 'Disease') :: ['Multiple Sclerosis']

answer: @entity15 :: (MESH:D009103,Disease) :: ['Multiple Sclerosis']


abstract: @entity174 of the tibial tuberosity are uncommon injuries that mainly occur in 14 to 16 year-old adolescents involved in sports activities. The mechanism of injury is related to jumping while practicing sports. This retrospective study presents the outcome of @entity174 of the tibial tuberosity in a series of 18 adolescent soccer players treated with the same surgical technique in one center. The hypothesis was that our surgical technique with two parallel screws, one proximal and one distal to the physis, avoids physis injury and has no repercussions on growth. The average age was 14.7 years. All @entity1 were male. The @entity174 included 4 type IIA, 3 type IIB, 6 type IIIA, and 5 type IIIB (Ogden classification). All @entity1 underwent open reduction and internal fixation consisting of screw placement parallel to the joint surface, sparing the tibial physis. There were no complications in any case, and all @entity1 were able to resume their previous sports activities. The technique used appeared to be safe. Screws were removed in 8 @entity1 owing to local discomfort. All @entity1 achieved the same competition level as before the injury.

title: Treatment of XXXX of the tibial tuberosity in adolescent soccer players.

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'Fractures']

answer: @entity174 :: (MESH:D050723,Disease) :: ['fractures']


abstract: OBJECTIVE: To study the awareness and acceptance of @entity1082 ) vaccination among sexually active @entity1 having sex with @entity1 (MSM) and @entity1 not having sex with @entity1 (MNSM) attending the largest @entity458 in Wuxi, China. METHODS: A questionnaire about @entity1 ' socio-demographic characteristics and view on HPV vaccination was collected. RESULTS: A total of 186 MSM and 182 MNSM were recruited. Among MSM, 12.4% were under 20  years old, 64.5% never married and 56.5% from Jiangsu Province (where Wuxi City is located); 64.0% had resided in Wuxi for over 2  years, 64.5% had high school education or more, and 83.9% had an income of 5000 RMB or less per month compared to figures of 5.5%, 50.6%, 73.6%, 54.9%, 86.8% and 64.8% among MNSM, respectively (All P values<0.05). Among these two groups of @entity1 , 18.4% and 23.1% had heard of HPV; 10.2% and 15.4% had heard of HPV vaccine; and 26.2% and 20.2% would take HPV vaccine before sexual debut, respectively. MNSM were significantly more willing to take HPV vaccine than MSM (70.9  vs 34.9%, p<0.001). Factors associated with HPV vaccine acceptance among MSM included engaging mostly in receptive anal sex (Odds ratio (OR)=3.9, 95% Confidence interval (CI): 1.8-13.5), never using a condom in anal sex in the past 6 months (3.5, 1.5-20.2), ever diagnosed with a @entity2953 ( @entity2953 ) (3.4, 1.3-8.4) and ever receiving @entity645 related services (1.6, 1.1-4.4). Among MNSM these Factors included commercial sex with @entity1 (1.7, 1.2-8.6), never using a condom in commercial sex (1.6, 1.4-7.6) and @entity2953 diagnosis (2.0, 1.6-7.3). CONCLUSIONS: Sexually active MSM and MNSM in Wuxi lacked knowledge of HPV and HPV vaccination. The majority of these at-risk @entity1 would not benefit from HPV vaccination as their age at first sex proceeded perceived age of vaccine uptake. Aggressive education aimed at increasing knowledge of HPV and HPV vaccination among these @entity1 is warranted.

title: Awareness and acceptance of XXXX ) vaccination among males attending a major @entity458 in Wuxi, China: A cross-sectional study.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'women', 'men']

entities_list: @entity2953 :: ('MESH:D012749', 'Disease') :: ['STI', 'sexually transmitted infection']

entities_list: @entity458 :: ('MESH:D020018', 'Disease') :: ['sexual health clinic']

entities_list: @entity1082 :: ('10566', 'Species') :: ['human papillomavirus (HPV']

answer: @entity1082 :: (10566,Species) :: ['human papillomavirus (HPV']


abstract: BACKGROUND: Several studies have found that Hispanics and @entity7864 have statistically significantly higher adjusted OR for @entity5 screening tests compared to non-Hispanic whites, even though their crude percentages were lower than, or about equal to, those for the non-Hispanic whites. Most documentation is for mammography. This article investigates the prevalence of such unadjusted-to-adjusted "reversed associations" (RA) for @entity2786 , colorectal, and prostate testing. We also investigate large percent changes (LPC) to the unadjusted ORs. METHODS: Data were from the 2004/2006/2008 Behavioral Risk Factor Surveillance System (BRFSS) and the 2000/2003/2005/2008 National Health Interview Survey (NHIS). Analyses used a consistent set of covariates. RESULTS: RAs were more common for @entity7864 than Hispanics, but Hispanics had a greater number of LPCs. RAs and LPCs occurred more often for Pap testing than colorectal and prostate testing. However, results from the BRFSS and NHIS were often not consistent. CONCLUSIONS: Attention should be given to the National Breast and @entity5 Early Detection Program, as well as public programs addressing other @entity5 , as possible contributors to RAs and LPCs. Hispanics may show more RAs in analyses of future data. Discrepancies between the BRFSS and the NHIS also must be recognized and explained. IMPACT: This research highlights the need for vigilance regarding the results of analyses to identify race/ethnicity as a correlate of @entity5 screening. Results also direct attention to aspects of the results of multivariable analysis other than ORs and confidence intervals.

title: Reversals of association for Pap, colorectal, and prostate cancer testing among XXXX women and men.

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancers', 'cancer', 'Cervical Cancer']

entities_list: @entity7864 :: ('MESH:D055008', 'Disease') :: ['non-Hispanic blacks']

answer: @entity7864 :: (MESH:D055008,Disease) :: ['Hispanic and non-Hispanic black']


abstract: BACKGROUND: @entity2399 is one of the most commonly prescribed intravenous medications in obstetrics. Despite its widespread use, there are limited data about @entity1760 pharmacokinetics, and @entity1760 is prescribed empirically without dose adjustment for different indications. OBJECTIVE: The aim of this study was to characterize the pharmacokinetics and placental transfer of @entity2399 in pregnant @entity1 and to determine key covariates that impact the pharmacokinetics. STUDY DESIGN: This is a prospective pharmacokinetic cohort study of  pregnant @entity1 who were prescribed @entity2399 for preeclampsia, @entity3152 , or extreme prematurity. @entity1 received a 4-g loading dose and 2 g/h maintenance dose as clinically indicated. Maternal blood samples were obtained before and at multiple time points during and after @entity1760 administration. Cord blood also was sampled at delivery. A population pharmacokinetic approach that used a nonlinear mixed-effects modeling was used to characterize @entity1760 disposition. RESULTS: Pharmacokinetic profiles of 111 pregnant @entity1 were analyzed. @entity1760 clearance was 3.98 L/h in preeclamptic @entity1 and  5.88 L/h non-preeclamptic @entity1 . Steady-state concentration of  @entity1760 was 7.2 mg/dL in preeclamptic @entity1 compared with 5.1  mg/dL in non-preeclamptic @entity1 . Maternal weight significantly impacted time to steady state. The ratio of the mean umbilical vein @entity1760 level to the mean maternal serum @entity1760 level at the time of delivery was 0.94    0.15. CONCLUSIONS: The study accurately characterizes the pharmacokinetics of @entity1760 administered to pregnant @entity1 . Preeclamptic status and maternal weight significantly impact serum @entity1760 levels. This pharmacokinetic model could be applied to larger cohorts to help tailor @entity1760 treatment and account for these covariates.

title: Pharmacokinetics and placental transfer of XXXX in pregnant @entity1 .

entities_list: @entity3152 :: ('MESH:D007752', 'Disease') :: ['preterm labor']

entities_list: @entity2399 :: ('MESH:D008278', 'Chemical') :: ['magnesium sulfate', 'Magnesium sulfate']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium', 'Magnesium']

answer: @entity2399 :: (MESH:D008278,Chemical) :: ['magnesium sulfate']


abstract: OBJECTIVE: @entity2 that invade the apical chest wall and surrounding structures. Treatment is complex and often involves surgery together with radio- and chemotherapy. We studied the outcome of surgical resection for @entity20330 in Iceland. MATERIALS AND METHODS: A retrospective study including all @entity1 that underwent resection of a @entity20330 with curative intent in Iceland in the years 1991-2010. Data on symptoms, complications, @entity2802 -stage, relapse and survival were analyzed. RESULTS: Twelve @entity1 were operated on; 7 on the right lung. Shoulder @entity158 (n=5) and/or @entity662 (n=3), cough (n=6) and @entity353 (n=5) were the most common presenting symptoms. @entity420 (n=5) and @entity957 (n=4) were the most frequent histological types. Average @entity5 size was 5,9 cm (range: 2,8-15). Five cases were stage IIB and 7 stage IIIA according to operative staging. In 10 cases (83%) the surgical margins were free of @entity5 . All @entity1 survived surgery and only one @entity1 suffered a major operative complication, an @entity954 . In one case induction chemo-radiation prior to surgery was administrated, and 8 @entity1 received postoperative radiotherapy. Recurrent disease was diagnosed in 9 @entity1 ; four had local or regional recurrence, four had distant metastases and one @entity1 was diagnosed with both local and distant recurrences simultaneously. Survival at 5 years was 33% and median survival was 27,5 months (range: 4-181). CONCLUSIONS: Operative and short-term outcomes for @entity1 with @entity20330 in Iceland are excellent. However, long-term outcomes are not as favorable and recurrence rate is high compared to other studies, possibly due to incomplete @entity5 and less use of chemo-radiation therapy prior to surgery among these @entity1 . Key words: @entity20330 , @entity1149 , treatment, outcome, relapse, survival. Correspondence: Tomas Gudbjartsson, tomasgud@landspitali.is.

title: [Outcome of surgical treatment for XXXX in Iceland].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity662 :: ('MESH:D002637', 'Disease') :: ['chest pain']

entities_list: @entity353 :: ('MESH:D015431', 'Disease') :: ['weight loss']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'preoperative staging']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['squamous cell carcinoma']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['Pancoast tumors are lung carcinomas']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['non-small cell lung cancer']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['Adenocarcinoma']

entities_list: @entity954 :: ('MESH:D016063', 'Disease') :: ['intraoperative bleeding']

entities_list: @entity20330 :: ('MESH:D010178', 'Disease') :: ['Pancoast tumors', 'Pancoast tumor']

answer: @entity2 :: (MESH:D008175,Disease) :: ['Pancoast lung carcinoma']


abstract: @entity900 based combination chemotherapy remains the mainstay for treatment of advanced @entity5 . The combination of @entity1487 and interferon has been found to be effective second line treatment of advanced @entity5 . Hence, we tested the combination of @entity900 , @entity1487 and interferon as first line therapy in advanced @entity5 . Eligible @entity1 had to have no prior chemotherapy or interferon. Treatment consisted of @entity900 80 mg/m(2) on day one, followed by @entity1487 750 mg/m(2) as a daily infusion for 5 days and @entity4020 5 MU/m(2) subcutaneously daily on day 1-5 of @entity1487 infusion. Cycles repeated every 21 days. Eighteen @entity1 , of which sixteen were males were enrolled. Median age was 60 years. All @entity1 had @entity1606 . The median number of cycles given was 4. Thirteen @entity1 were evaluable for response. Two @entity1 achieved CR and 3 PR for an overall response rate of 28% (95% confidence interval 7% to 49%). Median response duration was 8.3 months. Median survival was 5.5 months. Four @entity1 died secondary to chemotherapy @entity137 . Those were @entity937 in one, @entity3127 in one, @entity810 in one and one @entity1 died at home 3 weeks following the third cycle. The above regimen demonstrates excessive @entity137 and moderate activity. It cannot be recommended in its present format. Novel anti- @entity5 agents need to explored.

title: Phase II trial of @entity900 , @entity1487 , and XXXX as first line treatment of advanced @entity5 .

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'toxicities']

entities_list: @entity937 :: ('MESH:D012167', 'Disease') :: ['GI perforation']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'urothelial cancer']

entities_list: @entity900 :: ('MESH:D002945', 'Chemical') :: ['cisplatin', 'Cisplatin']

entities_list: @entity1606 :: ('MESH:D002295', 'Disease') :: ['transitional-cell carcinoma']

entities_list: @entity810 :: ('MESH:D058186', 'Disease') :: ['acute renal failure']

entities_list: @entity4020 :: ('3440', 'Gene') :: ['interferon alpha 2 B']

entities_list: @entity3127 :: ('MESH:D001996', 'Disease') :: ['bronchopneumonia']

entities_list: @entity1487 :: ('MESH:D005472', 'Chemical') :: ['5-fluorouracil']

answer: @entity4020 :: (3440,Gene) :: ['interferon-alpha-2B']


abstract: @entity2647 , a strong alpha-adrenergic receptor-stimulating agent, was compared with @entity1425 in 65 @entity1 with out-of-hospital @entity1167 , in a double-blind study. The resuscitation was performed by the physician-staffed Prehospital Emergency Care Unit of Helsinki University Central Hospital. The @entity1 received either 1.0 mg of @entity2647 or 0.5 mg of @entity1425 i.v. in the treatment of fine @entity2224 , @entity1167 or electromechanical dissociation. If two doses of either drug did not restore circulation, 0.5 mg of known 0.01% @entity1425 was given i.v., maximally twice. In the @entity1425 group, which consisted of 36 @entity1 with a mean age of 61 years, 10 @entity1 (28%) were successfully resuscitated. The @entity2647 group consisted of 29 @entity1 with a mean age of 62 years. In this group nine @entity1 (31%) were successfully resuscitated. The two groups were comparable regarding their apnoea-times, and there was no difference in the need for extra @entity1425 between the groups. No adverse effects, such as @entity101 or @entity1168 , were noted in the @entity1 treated with either @entity1425 or @entity2647 , nor did the overall rate of successful resuscitation fall during the test period. It is concluded that @entity2647 seems as effective as @entity1425 in the treatment of @entity1167 , but further studies seem warranted.

title: Comparison of XXXX and @entity2647 in out-of-hospital cardiopulmonary resuscitation. A double-blind study.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity1425 :: ('MESH:D004837', 'Chemical') :: ['adrenaline']

entities_list: @entity2647 :: ('MESH:D010656', 'Chemical') :: ['phenylephrine', 'Phenylephrine']

entities_list: @entity2224 :: ('MESH:D014693', 'Disease') :: ['ventricular fibrillation']

entities_list: @entity1167 :: ('MESH:D006323', 'Disease') :: ['cardiac arrest', 'asystole']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

answer: @entity1425 :: (MESH:D004837,Chemical) :: ['adrenaline']


abstract: OBJECTIVE: @entity1 with a history of @entity162 , postpartum @entity716 , or both are at high risk for postpartum relapse. The aim of this meta-analysis was to estimate the risk of postpartum relapse in these three @entity1 groups. METHOD: A systematic literature search was conducted in all public medical electronic databases, adhering to the PRISMA guidelines. Studies were included if they reported postpartum relapse in @entity1 diagnosed with @entity162 and/or a history of postpartum @entity716 or @entity162 according to DSM or @entity1479 criteria or the Research Diagnostic Criteria. RESULTS: Thirty-seven articles describing 5,700 deliveries in 4,023 @entity1 were included in the quantitative analyses. The overall postpartum relapse risk was 35% (95% CI=29, 41). @entity1 with @entity162 were significantly less likely to experience severe episodes postpartum (17%, 95% CI=13, 21) than @entity1 with a history of postpartum @entity716 (29%, 95% @entity13401 , 41). Insufficient information was available to determine relapse rates for @entity1 with @entity162 and a history of postpartum episodes. In @entity1 with @entity162 , postpartum relapse rates were significantly higher among those who were medication free during pregnancy (66%, 95% CI=57, 75) than those who used prophylactic medication (23%, 95% CI=14, 37). CONCLUSIONS: One-third of @entity1 at high risk experience a postpartum relapse. In @entity1 with @entity162 , continuation of prophylactic medication during pregnancy appears highly protective for maintaining mood stability postpartum. In @entity1 with a history of isolated postpartum @entity716 , initiation of prophylaxis immediately after delivery offers the opportunity to minimize the risk of relapse while avoiding in utero medication exposure.

title: Risk of Postpartum Relapse in XXXX and Postpartum Psychosis: A Systematic Review and Meta-Analysis.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'Patients', 'patients', 'patient', 'Women']

entities_list: @entity162 :: ('MESH:D001714', 'Disease') :: ['bipolar disorder', 'mania']

entities_list: @entity716 :: ('MESH:D011605', 'Disease') :: ['psychosis']

answer: @entity162 :: (MESH:D001714,Disease) :: ['Bipolar Disorder']


abstract: OBJECTIVE: We aimed to determine the diagnostic yield of continuous monitoring with video electroencephalography (cVEEG) for pediatric inpatients with paroxysmal vital sign changes (PVSCs), and to identify risk factors for the PVSCs being @entity410 , based on clinical information available before cVEEG initiation. We hypothesized that PVSCs without @entity1109 ( @entity1109 ) were unlikely to be @entity410 , and also that @entity1 ' clinical characteristics would alter the risk of recording @entity410 . METHODS: We performed a single-center chart review of 324 cVEEG studies that were obtained for differential diagnosis of PVSCs. We examined the type of PVSCs that prompted cVEEG, associated @entity1109 , and @entity1 characteristics, and whether the target events or @entity410 were recorded. We performed logistic regression analyses to determine which @entity1 and semiologic features altered the risk of the PVSCs being @entity410 , and which @entity1 characteristics altered the risk of recording any @entity410 . RESULTS: Target PVSCs were recorded in 52% (N = 169). @entity410 were recorded in 21% (N = 69) of the studies, often unrelated to the PVSCs (N = 39). When examining only PVSCs without @entity1109 , only 4% (3/75) of studies obtained for @entity386 and 2.1% (1/48) of studies obtained for @entity26 desaturation revealed the target events to be @entity410 . No studies recorded ictal @entity101 (0/26), @entity551 (0/16), or @entity1168 (0/18). In univariate analysis, there was a decreased risk that the events were @entity410 when PVSCs lacked @entity1109 (odds ratio [OR] 0.23, 95% confidence interval [CI] 0.08-0.65). The risk was increased when the @entity1 had received an antiseizure medication (2.9, 1.3-6.5), the target PVSC was @entity386 (3.5, 1.5-8.5), and in particular, @entity386 with @entity1109 (8.7, 3.7-20.8). In adjusted analyses, only @entity386 with associated @entity1109 independently increased the risk of the PVSCs being @entity410 (7.7, 3.2-18.5). SIGNIFICANCE: PVSCs in the absence of @entity1109 are rarely due to @entity410 . Ideally, cVEEG should be reserved for @entity1 with additional risk factors for @entity410 , beyond isolated PVSCs.

title: Diagnostic yield of continuous video electroencephalography for paroxysmal vital sign changes in pediatric XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity410 :: ('MESH:D012640', 'Disease') :: ['Seizures', 'seizures']

entities_list: @entity26 :: ('MESH:D010100', 'Chemical') :: ['oxygen']

entities_list: @entity1109 :: ('MESH:D012678', 'Disease') :: ['NAS', 'nonautonomic symptoms']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND AND OBJECTIVES: Bone demineralization is frequent in @entity1290 formers with @entity5200 . Although this pathologic link has been recognized for decades, the underlying mechanisms and risk factors associated with @entity2331 / @entity170 in this population remain partially understood. DESIGN, SETTING, @entity1 , _ MEASUREMENTS: This study retrospectively analyzed determinants of low @entity79 ( @entity79 ) in 65 idiopathic @entity12233 male @entity1290 formers. Clinical and biologic evaluation included @entity79 measurement, bone-remodeling markers, analysis of @entity460 metabolism with oral @entity460 load test, and dietary inquiry. RESULTS: @entity1 with @entity2331 (n=23, 35% of the population) presented significantly higher fasting calciuria as compared with normal bone density @entity1 (n=42) ( @entity460 / @entity1011 ratio was 0.32 versus 0.24 mmol/mmol; P=0.006). Analysis of the whole population revealed a negative association between fasting @entity5200 and @entity79 (P = 0.003), independent of confounding variables including body-mass index and @entity286 consumption. The fasting @entity460 / @entity1011 ratio above 0.25 mmol/mmol was associated with a 3.8-fold increase in the risk of low @entity79 . CONCLUSION: In our study, fasting @entity5200 after a 2-day @entity460 -restricted diet appears as the only biologic factor associated with low @entity79 , suggesting a bone- @entity460 efflux. Our results support the view of a parathyroid-independent pathologic process that remains to be identified. @entity12233 @entity1 with low @entity79 do not excrete more @entity460 in 24-hour urine samples than @entity1 without low @entity79 .

title: @entity2331 in male renal-stone-disease XXXX with idiopathic @entity5200 .

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'PARTICIPANTS']

entities_list: @entity170 :: ('MESH:D010024', 'Disease') :: ['osteoporosis']

entities_list: @entity12233 :: ('MESH:C562793', 'Disease') :: ['hypercalciuric', 'Hypercalciuric']

entities_list: @entity79 :: ('MESH:D001847', 'Disease') :: ['bone mineral density', 'BMD']

entities_list: @entity2331 :: ('MESH:D001851', 'Disease') :: ['osteopenia']

entities_list: @entity1290 :: ('MESH:D007669', 'Disease') :: ['renal-stone']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity5200 :: ('MESH:D053565', 'Disease') :: ['hypercalciuria']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: AIM: To evaluate the risks of medical conditions, evaluate @entity356 , and assess @entity384 to treat @entity1282 after @entity346 ( @entity346 ). METHODS: @entity346 is being performed more frequently worldwide as a treatment for medically-complicated @entity28 , and @entity1282 is common post-operatively. We hypothesize that post-operative @entity1282 is related to underlying medical conditions or narrowing of the @entity356 . This is a retrospective, single institution study of consecutive @entity1 who underwent sleeve gastrectomy from 2013 to 2015. @entity1 with previous bariatric procedures were excluded. Narrowing of a @entity356 includes: inability to pass a 9.6 mm gastroscope due to @entity850 or sharp angulation or spiral hindering its passage. RESULTS: Of 400 consecutive @entity1 , 352 are included; the prevalence of @entity1282 is 22.7%; 33 @entity1 (9.3%) have narrowing of the sleeve with 25 (7.1%) having sharp angulation or a spiral while 8 (2.3%) have a @entity850 . All 33 @entity1 underwent balloon dilatation of the @entity356 and @entity1282 resolved in 13 @entity1 (39%); 10 @entity1 (30%) noted resolution of @entity1282 after two additional dilatations. In a multivariate model, medical conditions associated with post-operative @entity1282 include @entity6 , symptoms of @entity354 , a low whole blood @entity9138 level, @entity1375 , use of non-steroidal anti-inflammatory drugs, and use of opioids. CONCLUSION: Narrowing of the @entity356 and @entity356 are common after @entity346 . @entity6676 resolves @entity1282 in 69% of @entity1 .

title: XXXX after @entity346 : Evaluation of risk factors and assessment of endoscopic intervention.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1375 :: ('MESH:D007037', 'Disease') :: ['hypothyroidism']

entities_list: @entity6676 :: ('MESH:D013271', 'Disease') :: ['Endoscopic balloon dilatations of the gastric sleeve']

entities_list: @entity28 :: ('MESH:D009765', 'Disease') :: ['obesity']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes mellitus']

entities_list: @entity384 :: ('MESH:D002311', 'Disease') :: ['hydrostatic balloon dilatation']

entities_list: @entity9138 :: ('MESH:D013831', 'Chemical') :: ['thiamine']

entities_list: @entity1282 :: ('MESH:D003680', 'Disease') :: ['dysphagia']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['esophageal reflux']

entities_list: @entity850 :: ('MESH:D003251', 'Disease') :: ['stenosis']

entities_list: @entity346 :: ('MESH:D009759', 'Disease') :: ['VSG', 'vertical sleeve gastrectomy']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric sleeve narrowing', 'gastric sleeve', 'gastric sleeve stenosis']

answer: @entity1282 :: (MESH:D003680,Disease) :: ['Dysphagia']


abstract: STUDY DESIGN: Prospective single-center study. OBJECTIVE: To analyze the efficacy and safety of a new technique of global vertebral correction with convex rod rotation performed on the @entity1 with @entity1615 . SUMMARY OF BACKGROUND DATA: Surgical goal is to obtain an optimal curve correction in @entity1635 surgery. There are various correction techniques. This report describes a new technique of global vertebral correction with convex rod rotation. MATERIALS AND METHODS: A total of 12 consecutive @entity1 with @entity196 @entity1615 and managed by convex rod rotation technique between years 2012 and 2013 having more than 1 year follow-up were included. Mean age was 14.5 (range = 13-17 years) years at the time of operation. The hospital charts were reviewed for demographic data. Measurements of curve magnitude and balance were made on 36-inch standing anteroposterior and lateral radiographs taken before surgery and at most recent follow up to assess deformity correction, spinal balance, and complications related to the instrumentation. RESULTS: Preoperative coronal plane major curve of 62   (range = 50  -72  ) with flexibility of less than 30% was corrected to 11.5  (range = 10  -14  ) showing a 81% @entity1635 correction at the final follow-up. Coronal imbalance was improved 72% at the most recent follow-up assessment. No complications were found. CONCLUSION: The new technique of global vertebral correction with Ucar's convex rod rotation is an effective technique. This method is a vertebral rotation procedure from convex side and it allows to put screws easily to the concave side.

title: A new corrective technique for XXXX (Ucar's convex rod rotation).

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity196 :: ('MESH:D020754', 'Disease') :: ['Lenke type I']

entities_list: @entity1635 :: ('MESH:D012600', 'Disease') :: ['scoliosis']

entities_list: @entity1615 :: ('OMIM:181800', 'Disease') :: ['adolescent idiopathic scoliosis']

answer: @entity1615 :: (OMIM:181800,Disease) :: ['adolescent idiopathic scoliosis']


abstract: CASE DESCRIPTION: A 6-year-old Siberian Husky-mix @entity235 was examined for episodes of collapse. CLINICAL FINDINGS: Physical examination, echocardiography, abdominal ultrasonography, ECG, and thoracic computed tomography with contrast were performed and revealed a 2.5   2.3   2.0-cm mass over the pulmonic @entity340 , resulting in moderate @entity849 . Other abnormal findings included systemic @entity101 , @entity714 , @entity644 , and a urinary bladder mass. TREATMENT AND OUTCOME: Pulmonary arteriotomy was performed under @entity432 , and the mass was resected with transesophageal echocardiographic guidance and direct visualization. Results of histologic examination of the mass revealed @entity4607 . Sequential follow-up examinations and telephone contacts (at 0.5, 5, and 15 months after surgery) revealed that the @entity1 had been free from episodes of collapse since surgery. No regrowth of the mass was noted on follow-up echocardiograms, and the @entity849 had resolved, although mild to moderate @entity338 later developed. The bladder mass was excised 15 months after the first surgery when @entity811 developed, and results of histologic examination of this mass revealed @entity4607 . The @entity235 was eventually euthanized 31 months after the initial surgery for reasons that could not be directly linked to any recurrence of the pulmonary artery mass. CLINICAL RELEVANCE: @entity4607 are @entity5 that can be located in various tissues, including large arteries. Computed tomography was helpful in predicting the resectability of the @entity4615 in this @entity235 . Treatment with arteriotomy under @entity432 and mild @entity2332 resulted in a favorable outcome.

title: Surgical treatment of a pulmonary artery vascular hamartoma in a XXXX .

entities_list: @entity644 :: ('MESH:D011507', 'Disease') :: ['proteinuria']

entities_list: @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity714 :: ('MESH:D002037', 'Disease') :: ['right bundle branch block']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['benign tumors']

entities_list: @entity338 :: ('MESH:D011665', 'Disease') :: ['pulmonary insufficiency']

entities_list: @entity849 :: ('MESH:D011666', 'Disease') :: ['pulmonic stenosis']

entities_list: @entity4615 :: ('MESH:C538262', 'Disease') :: ['intracardiac mass']

entities_list: @entity432 :: ('MESH:D001157', 'Disease') :: ['inflow occlusion']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valve leaflets']

entities_list: @entity4607 :: ('MESH:D006222', 'Disease') :: ['a vascular hamartoma', 'Hamartomas']

entities_list: @entity2332 :: ('MESH:D007035', 'Disease') :: ['hypothermia']

answer: @entity235 :: (9615,Species) :: ['dog']


abstract: @entity3555 still remains a serious disease with significant morbidity and mortality. In @entity1 with known @entity340 , most cases are caused by oral viridans streptococci. These organisms are present in vast numbers on the gum margins and in gum pockets. They cause transient @entity582 during eating and tooth brushing. More substantial, but short-lived @entity582 can occur during dental treatment such as extraction and scaling. Bacteria may then become attached to abnormal endocardium leading to the development of @entity884 . Prophylaxis of @entity884 during dental procedures in @entity1 with known @entity340 should thus be aimed at reducing the number of bacteria entering the blood stream and eliminating those that get there. This can be sought first by good oro-dental hygiene and secondly by the use of prophylactic antibiotics. In this paper, we set out simple guidelines for practitioners in those countries that do not already have recommendations of their own. They are based on guidelines already in use in the United Kingdom, France, Switzerland and the United States.

title: Prophylaxis of XXXX for dental procedures. Report of a working party of the European Society of Cardiology.

entities_list: @entity582 :: ('MESH:C531821', 'Disease') :: ['bacteraemia']

entities_list: @entity340 :: ('MESH:D006349', 'Disease') :: ['valve disease']

entities_list: @entity3555 :: ('MESH:D004697', 'Disease') :: ['Bacterial endocarditis']

entities_list: @entity884 :: ('MESH:D004696', 'Disease') :: ['infective endocarditis', 'endocarditis']

answer: @entity884 :: (MESH:D004696,Disease) :: ['infective endocarditis']


abstract: PURPOSE: To evaluate which parameters of dynamic magnetic resonance (MR) imaging and T2 relaxation rate would result in optimal discrimination of @entity263 from normal peripheral zone (PZ) and central gland (CG) tissues and to correlate these parameters with @entity5 stage, Gleason score, @entity1 age, and @entity5 markers. MATERIALS AND METHODS: Of 58 @entity1 with @entity263 , 36 were included for analysis. @entity1 underwent MR imaging at 1.5 T with an endorectal-pelvic phased-array coil and subsequently underwent prostatectomy. A T2-weighted turbo spin-echo sequence, an intermediate-weighted sequence, and a fast T1-weighted gradient-echo sequence (seven sections in 2.03 seconds) during bolus injection of 0.1 mmol @entity7241 per kilogram of body weight were performed. Contrast agent concentration-time curves were obtained for @entity263 and normal PZ and CG tissue by using whole-mount sections to guide placement of regions of interest. Onset time, time to peak, peak enhancement, relative peak enhancement, washout, and T2 relaxation rates were calculated. Multivariate receiver operating characteristic analysis was performed with and without relative peak enhancement. RESULTS: Results of multivariate receiver operating characteristic analysis showed that relative peak enhancement demonstrated the highest area under the receiver operating characteristic curve (AUC) in the PZ and the CG (AUC = 0.93, 0.82). Results of multivariate analysis without relative peak enhancement showed that relative peak enhancement in the PZ and washout in the CG demonstrated the highest AUC (AUC = 0.9, 0.81). Pearson correlation coefficients between the dynamic parameters or T2 relaxation rates in @entity189 and the @entity5 stage, Gleason score, @entity1 age, and @entity5 markers ranged between 0.02 and 0.44. CONCLUSION: The optimal parameter for discrimination of @entity263 in the PZ and CG was relative peak enhancement. If relative peak enhancement was not used, then peak enhancement was optimal in the PZ, and washout was optimal in the CG. Poor-to-moderate correlation was present between the dynamic parameters or T2 relaxation rate in @entity189 and the @entity5 stage, Gleason score, @entity1 age, @entity5 volume, and @entity1486 .

title: XXXX from normal peripheral zone and central gland tissue by using dynamic contrast-enhanced MR imaging.

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['prostatic carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinoma']

entities_list: @entity7241 :: ('MESH:D019786', 'Chemical') :: ['gadopentetate dimeglumine']

entities_list: @entity1486 :: ('354', 'Gene') :: ['prostate-specific antigen']

answer: @entity263 :: (MESH:D011471,Disease) :: ['Discrimination of prostate cancer']


abstract: UNASSIGNED: @entity1362 is a rare proliferative condition of the synovium that affects large joints. The primary treatment options are synovectomy and a combination of synovectomy and arthroplasty. We performed a systematic review of the literature, excluding all nonclinical and review articles with follow-up of less than 2 years. Primary outcomes reported were disease recurrence, symptom progression, and revision surgery. Student t tests were used to compare outcomes after synovectomy with outcomes after synovectomy combined with arthroplasty. Twenty-one studies (82 @entity1 ) were included. All represented level IV or V evidence. Fifty-one @entity1 (59.3%) were female. Mean (SD) age was 33.2 (12.6) years. Synovectomy alone was performed in 45 @entity1 (54.9%), and synovectomy with arthroplasty was performed in 37 @entity1 (45.1%). Mean (SD) follow-up was 8.4 (5.9) years. The groups' revision rates were not significantly different (26.2% vs 24.3%; P = .17). Mean (SD) time to revision was significantly (P = .02) longer in the synovectomy-with-arthroplasty group, 11.8 (4.5) years, than in the synovectomy-only group, 6.5 (3.9) years. Study results showed revisions are common after surgery for hip @entity1362 , affecting 1 in 4 @entity1 regardless of which surgery they have-either synovectomy alone or synovectomy combined with arthroplasty. Revision is required sooner in synovectomy-only @entity1 than in @entity1 who also undergo arthroplasty.

title: XXXX of the Hip: A Systematic Review.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity1362 :: ('MESH:D013586', 'Disease') :: ['pigmented villonodular synovitis', 'Pigmented villonodular synovitis']

answer: @entity1362 :: (MESH:D013586,Disease) :: ['Pigmented Villonodular Synovitis']


abstract: @entity1951 and @entity398 neuroendocrine cells within the @entity2339 ( @entity4525 ) display mRNA expression for the @entity143 receptor subunits, @entity4474 and @entity4319 , @entity4477 and @entity4475 . The @entity4319 subunit confers slow decay kinetics (relative to @entity4474 / @entity4476 receptors) and high @entity1760 sensitivity to @entity143 receptor responses--properties which may contribute to the @entity143 receptor-mediated bursting manifested by these cells. Therefore, we examined @entity4319 protein expression and its developmental profile in the @entity4525 and compared it to that in the cortex and cerebellum--areas which have been studied previously. We performed Western blot analysis on @entity4525 homogenates from embryonic, postnatal (PN7, 14, 21), and adult @entity35 using an @entity4319 -specific antibody. Adult @entity4319 levels in the @entity4525 and PVN were similar but low relative to those of cortex. @entity4525 @entity4319 protein levels rose in the first postnatal week, remained high through PN21, and later declined to significantly lower levels in the adult. A similar profile was observed in cerebellum, where @entity4319 expression displayed a sharp peak at PN14 and later declined to minimal or undetectable levels in the adult. In contrast, @entity4319 continued to be overexpressed through adulthood in the cortex. The ontogenic pattern for @entity4474 expression, which included unregulation during early postnatal life and adulthood, was similar in the @entity4525 and cortex. A different pattern was observed for the cerebellum, where @entity4474 levels increased gradually after ED17 to reach significantly greater adult levels. Of all three areas studied, the @entity4525 displayed the earliest developmental rise in @entity4474 levels. @entity4525 explant cultures proved to be a useful preparation, since they contained neurons which synthesized @entity4474 and @entity4319 subunits in quantities similar to those of ED17 @entity4525 . Our findings suggest that @entity143 receptors on @entity4525 neuroendocrine cells are assembled using @entity4474 and @entity4319 subunits, and that their plastic expression in early postnatal life may play a role during development.

title: Developmental plasticity of @entity4474 and XXXX subunit expression in the supraoptic nucleus of the @entity35 hypothalamus.

entities_list: @entity398 :: ('MESH:D010121', 'Chemical') :: ['oxytocin']

entities_list: @entity1951 :: ('MESH:D014667', 'Chemical') :: ['Vasopressin']

entities_list: @entity2339 :: ('MESH:D007029', 'Disease') :: ['supraoptic nucleus of the adult hypothalamus']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity4319 :: (24410(Tax:10116),Gene) :: ['NR2B']


abstract: Mucosa-associated lymphoid tissue (MALT) @entity706 is a relatively common, indolent @entity1892 . @entity1074 with large @entity5 cells (LTCs) is believed to have the potential to transform to aggressive @entity1892 ( @entity1892 ) which may have a poor prognosis. @entity517 is a transcription factor. Its translocation and overexpression predicts an inferior prognosis and poor response to therapy in cases of @entity1892 . In the current study, @entity517 expression was detected in @entity1074 , and its relationship to the occurrence of LTCs, clinicopathological parameters and prognosis was assessed. A total of 69 cases were enrolled in the study, including 42 cases of @entity1074 without LTCs, 20 cases of @entity1074 with LTCs and 7 cases of @entity1892 with a @entity1074 component ( @entity1892 +MALT). Immunohistochemistry and fluorescent in situ hybridization analyses were performed. In total, 15/42 (35.7%) cases were nuclear positive for @entity517 expression in the group without LTCs, whereas 15/20 (75.0%) and 4/7 (57.1%) cases were positive in the group with LTCs and in the group with @entity1892 +MALT, respectively (P=0.004). Univariate and multivariate analysis were used to determine the correlations of @entity517 expression and clinicopathological parameters with @entity1349 ( @entity1349 ). @entity517 expression, Ann Arbor stage, LDH level and IPI were considerably associated with @entity1349 according to the univariate analysis. However, only @entity517 expression >= 20% showed a statistical significance in the multivariate analysis (HR=20.604, 95% CI: 1.909-222.412, P=0.013). Therefore, @entity517 overexpression may play an important role in aggressive transformation and is an independent prognostic factor in @entity1074 .

title: @entity517 overexpression predicts aggressive transformation and a poor outcome in mucosa-associated XXXX .

entities_list: @entity706 :: ('MESH:D008223', 'Disease') :: ['lymphoma']

entities_list: @entity1074 :: ('MESH:D018442', 'Disease') :: ['MALT lymphoma', 'MALT lymphomas']

entities_list: @entity1892 :: ('MESH:D016393', 'Disease') :: ['DLBCL', 'B-cell lymphoma', 'diffuse large B-cell lymphoma']

entities_list: @entity1349 :: ('MESH:D011475', 'Disease') :: ['OS', 'overall survival']

answer: @entity706 :: (MESH:D008223,Disease) :: ['lymphoid tissue lymphomas']


abstract: Highly differentiated sex chromosomes create a lethal imbalance in gene expression in one sex. To accommodate hemizygosity of the X chromosome in male @entity238 , expression of X-linked genes increases twofold. This is achieved by the @entity3930 ( @entity3930 ) complex, which modifies chromatin to increase expression. Mutations that disrupt the X localization of this complex decrease the expression of X-linked genes and reduce male survival. The mechanism that restricts the @entity3930 complex to X chromatin is not understood. We recently reported that the siRNA pathway contributes to localization of the @entity3930 complex, raising questions about the source of the siRNAs involved. The X-linked 1.688 g/cm(3) satellite related repeats (1.688(X) repeats) are restricted to the X chromosome and produce small RNA, making them an attractive candidate. We tested RNA from these repeats for a role in dosage compensation and found that ectopic expression of single-stranded RNAs from 1.688(X) repeats enhanced the male lethality of mutants with defective X recognition. In contrast, expression of double-stranded hairpin RNA from a 1.688(X) repeat generated abundant siRNA and dramatically increased male survival. Consistent with improved survival, X localization of the @entity3930 complex was largely restored in these males. The striking distribution of 1.688(X) repeats, which are nearly exclusive to the X chromosome, suggests that these are cis-acting elements contributing to identification of X chromatin.

title: siRNAs from an X-linked satellite repeat promote X-chromosome recognition in XXXX .

entities_list: @entity3930 :: ('MESH:D005834', 'Disease') :: ['MSL', 'male- specific lethal']

entities_list: @entity238 :: ('7227', 'Species') :: ['fruit flies']

answer: @entity238 :: (7227,Species) :: ['Drosophila melanogaster']


abstract: OBJECTIVES: To present a model of decision and cost-effectiveness analysis that allows assessing the trade-off between the short-term risks of performing a carotid endarterectomy and the rate of preventable future events and the impact of real-world adherence of best medical treatment on cost-effectivenss of both therapeutic options. METHODS: We used data from current literature to define values for a base case and perform a sensitivity analysis. The primary endpoint was a comparison of the fatal and disabling @entity64 -free survival during a 5-year period in a cohort of hypothetical @entity1 who presented asymptomatic severe @entity543 and were treated with either prophylactic carotid endarterectomy or adherent and non-adherent best medical treatment, respectively. RESULTS: The difference in estimated fatal and disabling @entity64 -free survival favoring endarterectomy in @entity1 with asymptomatic severe @entity543 is 44 days over the course of 5 years in case of non-adherent best medical treatment. Over a 5-year time horizon, prophylactic @entity787 would be cost-effective in 50.8% of bootstrap replicates and non-persistent BMT might be economically dominant in 11.1%. The probability that @entity787 would be cost-effective at a willingness-to-pay threshold of @entity7634 50 000/QALY gained was 71.8 %. In 17.9 % prophylactic @entity787 would be more costly and effective than persistent BMT, but its @entity10679 was greater than the WTP, so persistent BMT would be optimal. CONCLUSIONS: In this model, in case of real-world drug adherence it was likely that a strategy of early endarterectomy might be a cost-effective or even the dominant therapeutic option in comparison with a strategy of medical therapy alone (deferred surgery). If background any-territory @entity64 rates on contemporary medical therapy would fall substantially below 0.7 per cent, surgery would cease to be cost-effective.   .

title: Impact of real-world adherence with best medical treatment on cost-effectiveness of carotid endarterectomy for asymptomatic XXXX .

entities_list: @entity543 :: ('MESH:D016893', 'Disease') :: ['carotid stenosis']

answer: @entity543 :: (MESH:D016893,Disease) :: ['carotid artery stenosis']


abstract: Adequate indoor-air quality (IAQ)-defined by the temperature, relative humidity, and the levels of @entity544 , small particles, and total volatile organic compounds (TVOC)-is crucial in laboratory animal facilities. The ventilation standards for controlling these parameters are not well defined. This study assessed the effect of 2 ventilation strategies on IAQ in 2 rooms housing @entity2608 ( @entity2608 ). We hypothesized that using a demand-controlled ventilation ( @entity14637 ) system with a baseline ventilation rate of less than 3 @entity11535 ( @entity11535 ) would maintain IAQ comparable to or better than the traditional constant flow rate (CFR) system at 12 fresh @entity11535 . During a 60-d study period, each of the 2 rooms operated 30 d on @entity14637 and 30 d on CFR ventilation. In both rooms, temperatures remained more consistently within the established setpoint during the @entity14637 phase than during the CFR phase. Relative humidity did not differ significantly between rooms or strategies. @entity3158 was lower during the CFR phase than @entity14637 phase. Small-particle and TVOC levels were lower during CFR in the larger (3060 ft(3)) room but not the smaller (2340 ft(3)) room. During the @entity14637 phase, the larger room was at the baseline airflow rate over 99% of the time and the smaller room over 96% of the time. The @entity14637 strategy resulted in a baseline airflow rate of less than 3 @entity11535 , which in turn provided acceptable IAQ over 96% of the time; higher ventilation rates were warranted only during sanitation periods.

title: Comparison of Indoor Air Quality between 2 Ventilation Strategies in a Facility Housing @entity2608 ( XXXX ).

entities_list: @entity11535 :: ('MESH:D009041', 'Disease') :: ['fresh-air changes per hour', 'ACH']

entities_list: @entity544 :: ('MESH:D002245', 'Chemical') :: ['carbon dioxide']

entities_list: @entity2608 :: ('9544', 'Species') :: ['Macaca mulatta', 'rhesus macaques']

answer: @entity2608 :: (9544,Species) :: ['Macaca mulatta']


abstract: This review of @entity944 in @entity1 previously seen in a pediatric cardiology clinic attempts to identify factors that may have been predictive of @entity944 . The denominator for these factors is unknown. For example, the number of @entity1 with these possible risk factors who have well tolerated @entity943 is not known. Further studies are planned to document the incidence of these factors in @entity1 with similar lesions whom we continue to follow up. The following conclusions can be drawn from the study: More than three-quarters of the @entity1 who died suddenly had severe limitation of activity, @entity299 on chest radiograph or poor hemodynamic status at cardiac catheterization. The majority of @entity1 who died suddenly had an @entity943 in the 12 month period before death. A significant number of these @entity943 developed for the first time in the year before death. The presence of @entity943 was generally related to poor hemodynamic status in @entity1 who died suddenly. Most sudden @entity204 occurred with the @entity1 at rest and only approximately one-quarter occurred during participation in sports. Each cardiac diagnosis had its own specific profile of types of @entity943 Conspicuously absent from the list of diagnoses were @entity1 with a normal heart and @entity1 with @entity3454 .(ABSTRACT TRUNCATED AT 250 WORDS)

title: @entity944 in a pediatric cardiology population, 1958 to 1983: relation to prior XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'patient']

entities_list: @entity944 :: ('MESH:D003645', 'Disease') :: ['sudden death']

entities_list: @entity3454 :: ('MESH:D008945', 'Disease') :: ['mitral valve prolapse']

entities_list: @entity299 :: ('MESH:D006331', 'Disease') :: ['cardiac enlargement']

entities_list: @entity943 :: ('MESH:D001145', 'Disease') :: ['arrhythmias', 'arrhythmia']

answer: @entity943 :: (MESH:D001145,Disease) :: ['arrhythmias']


abstract: OBJECTIVE: To observe pressure changes in the spinal canal of the vertebrarium subjected to impact. From the point of view of impact, pressure changes and @entity1566 , the relationship between the type of @entity174 and the severity of @entity1566 were analyzed and some experimental data were provided for early evaluation of severity of @entity1566 . METHODS: An experimental model of @entity174 was made with Type BIM-I bio-impact machine and techniques of high velocity vertical loading in static pattern and stress shielding were adopted. Vertebral sections T10-L4 taken from fresh cadavers were impacted and pressure changes in the spinal canal were observed. The types and severity of @entity174 were studied with gross and radiography examination. RESULTS: Great positive pressure wave (wave A) in the spinal canal of the 4 vertebral specimens with @entity174 was recorded. The peak value of pressure was correlated with the severity of posterior column injuries. Generally, the peak value of pressure was low in the samples with posterior column injuries, but high in the samples without injuries. The predominant features of @entity174 were @entity174 and severe destruction of the skeletal and fiber structure of the spinal canal. Positive and negative pressure waves (wave B) were recorded in 2 vertebral samples in which no significant abnormal changes were found by radiography examination, however, a little liquid effusion in the vertebral body was found by gross examination. CONCLUSIONS: The type of pressure wave in the spinal canal is related to the deformation or the destruction of the spinal canal structure. The peak value of the pressure is non-linearly related to the obstruction in the spinal canal, but related to posterior column injuries.

title: Pressure changes in spinal canal and evaluation of XXXX in spinal section subjected to impact.

entities_list: @entity1566 :: ('MESH:D013119', 'Disease') :: ['spinal cord injuries']

entities_list: @entity174 :: ('MESH:D050723', 'Disease') :: ['fractures', 'spinal burst fracture', 'burst fracture', 'spinal fracture', 'burst fractures of vertebral body']

answer: @entity1566 :: (MESH:D013119,Disease) :: ['spinal cord injuries']


abstract: BACKGROUND: @entity1576 caused by @entity1800 is associated with the development and exacerbation of childhood @entity565 . Little is known about the effects of respiratory @entity1800 in the absence of illness. Using quantitative PCR (qPCR) for common respiratory viruses and for two genes known to be highly upregulated in @entity1800 ( @entity12869 / @entity372 ), we screened 92 asthmatic and 69 healthy @entity1 without illness for @entity1729 . RESULTS: We found 21 viral qPCR-positive and 2 suspected @entity778 subjects with high expression of @entity12869 / @entity372 . We applied a dual RNA-seq workflow to these subjects, together with 25 viral qPCR-negative subjects, to compare qPCR with sequencing-based virus detection and to generate the airway transcriptome for analysis. RNA-seq virus detection achieved 86% sensitivity when compared to qPCR-based screening. We detected additional respiratory viruses in the two @entity12869 / @entity372 -high subjects and in two of the qPCR-negative subjects. Viral read counts varied widely and were used to stratify subjects into Virus-High and Virus-Low groups. Examination of the host airway transcriptome found that the Virus-High group was characterized by immune cell airway infiltration, downregulation of cilia genes, and dampening of type 2 @entity32 . Even the Virus-Low group was differentiated from the No-Virus group by 100 genes, some involved in @entity38270 signaling. CONCLUSIONS: @entity1729 without illness is not innocuous but may determine the airway function of these subjects by driving immune cell airway infiltration, cellular remodeling, and alteration of asthmogenic gene expression.

title: Dual RNA-seq reveals @entity1800 in asthmatic XXXX without @entity1576 which are associated with changes in the airway transcriptome.

entities_list: @entity1 :: ('9606', 'Species') :: ['children']

entities_list: @entity778 :: ('MESH:D015658', 'Disease') :: ['virus-infected']

entities_list: @entity32 :: ('MESH:D007249', 'Disease') :: ['inflammation']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infections', 'viral infection']

entities_list: @entity1576 :: ('MESH:D012131', 'Disease') :: ['Respiratory illness']

entities_list: @entity1729 :: ('MESH:D012141', 'Disease') :: ['Respiratory virus infection', 'respiratory virus infections']

answer: @entity1 :: (9606,Species) :: ['children']