abstract: AIMS: The @entity1133 breath test may have value in the initial assessment of @entity2210 in primary care. This pilot study tracks @entity1 and general practitioner behaviour which cannot be predicted with modelling studies. METHODS: The @entity1133 breath test was made available over a period of 18 months. The test was requested when general practitioners would normally have used a trial of medication or referred for endoscopy. @entity1 with a positive @entity1133 breath test had early endoscopy before treatment. @entity1 with a negative @entity1133 breath test were treated according to symptom response. A follow-up questionnaire was given 6-24 months after the @entity1133 breath test. RESULTS: @entity1133 breath tests were requested on 249 @entity1 ; clinical notes and follow-up interview data were available for 207 @entity1 (83%). The @entity1133 breath test was positive for 89 @entity1 (43%); 70 were referred for endoscopy and @entity10189 was found in 33 (47%). The @entity1133 breath test was negative for 118 @entity1 ; 14 were follow-up tests after previous @entity1534 treatment. For the 104 @entity1 with @entity2210 , a negative test and no previous treatment, 42% had 1 or more previous investigations for @entity2210 and 66% had @entity2210 symptoms for more than one year. During follow-up, 21 @entity1 had endoscopy. Dyspepsia symptom scores were significantly lower at follow-up (p < 0.01). Using a global assessment, 66% had fewer symptoms, 22% same and 12% had more symptoms. The symptom improvement was greater if the duration of symptoms was less than one year (p < 0.05). Medication use did not change significantly. Twelve @entity1 were dissatisfied with management; most of these would have preferred endoscopy. CONCLUSIONS: A negative @entity1133 breath test appears to have some reassurance value. The use of the @entity1133 breath test as initial assessment for dyspespia may prevent the need for some endoscopy. Further controlled studies of breath testing compared with early endoscopy are required.

title: Can the XXXX breath test for @entity1534 replace endoscopy for the assessment of @entity2210 in primary care?

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients', 'patient']

entities_list: @entity10189 :: ('MESH:D010437', 'Disease') :: ['peptic ulcer disease']

entities_list: @entity2210 :: ('MESH:D004415', 'Disease') :: ['dyspepsia']

answer: @entity1133 :: (MESH:D014508,Chemical) :: ['urea']


abstract: Acquired genomic aberrations have been shown to significantly impact survival in several @entity1583 . We analyzed the prognostic value of the most frequent chromosomal changes in a large series of @entity1 with newly diagnosed symptomatic @entity1582 prospectively enrolled in homogeneous therapeutic trials. All the 1064 @entity1 enrolled in the IFM99 trials conducted by the Intergroupe Francophone du My  lome benefited from an interphase fluorescence in situ hybridization analysis performed on purified bone marrow plasma cells. They were systematically screened for the following genomic aberrations: del(13), t(11;14), t(4;14), hyperdiploidy, MYC translocations, and del(17p). Chromosomal changes were observed in 90% of the @entity1 . The del(13), t(11;14), t(4;14), hyperdiploidy, MYC translocations, and del(17p) were present in 48%, 21%, 14%, 39%, 13%, and 11% of the @entity1 , respectively. After a median follow-up of 41 months, univariate statistical analyses revealed that del(13), t(4;14), nonhyperdiploidy, and del(17p) negatively impacted both the event-free survival and the overall survival, whereas t(11;14) and MYC translocations did not influence the prognosis. Multivariate analyses on 513 @entity1 annotated for all the parameters showed that only t(4;14) and del(17p) retained prognostic value for both the event-free and overall survivals. When compared with the currently used International Staging System, this prognostic model compares favorably. In @entity1582 , the genomic aberrations t(4;14) and del(17p), together with @entity2262 level, are important independent predictors of survival. These findings have implications for the design of risk-adapted treatment strategies.

title: Genetic abnormalities and survival in multiple XXXX : the experience of the Intergroupe Francophone du My  lome.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity2262 :: ('567', 'Gene') :: ['beta2-microglobulin']

entities_list: @entity1583 :: ('MESH:D019337', 'Disease') :: ['hematologic malignancies']

answer: @entity1582 :: (MESH:D009101,Disease) :: ['myeloma']


abstract: UNASSIGNED: @entity734 ( @entity734 ) exhibit high biological activity, they are cytotoxic, genotoxic, and are constantly released into the environment as a result of incomplete metabolism. Consequently they pose a serious threat to the environment and @entity1 health due to their carcinogenic, mutagenic and/or reproductive @entity137 properties. Knowledge of their bioavailability, including their sorption to soils and their impact on the soil-groundwater pathway, is crucial for their risk assessment. Laboratory batch and column leaching tests are important tools for determining the release potential of contaminants from soil or waste material. Batch and column tests were carried out with soils differing in physicochemical properties, each spiked with @entity786 (CK) or @entity1260 (IF). Moreover, due to the fact that environmental pollutants may occur as coexisting compounds in the soil the mobility evaluation for @entity734 in the mixture with @entity1406 ( @entity4508 ; b-blocker) as a co-contaminant was performed. In order to assess appropriateness, the batch and column tests were compared. The release depended on the properties of both the soil and the presence of co-contaminants. The faster release was observed for coarse-grained soil with the smallest organic matter content (MS soil: 90% decrease in concentration until liquid-to-solid ratio (L/S) of 0.3Lkg(-1) for all tests' layout) than for loamy sand (LS soil: 90% decrease in concentration until ratio L/S of 0.75Lkg(-1)). @entity734 are highly mobile in soil systems. Furthermore, the decrease of mobility of @entity1260 was observed with the presence of a co-contaminant ( @entity1406 ) in both of the soils (in MS soil a decrease of 29%; in LS soil a decrease of 26%). The mobility of @entity786 does not depend on the presence of a contaminant for MS soil, but also exhibits a decrease of 21% in LS soil.

title: The leaching behavior of XXXX and @entity1260 from soil in the presence of co-contaminant - Mixture sorption approach.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity']

entities_list: @entity786 :: ('MESH:D003520', 'Chemical') :: ['cyclophosphamide']

entities_list: @entity1406 :: ('MESH:D008790', 'Chemical') :: ['metoprolol']

entities_list: @entity1260 :: ('MESH:D007069', 'Chemical') :: ['ifosfamide']

entities_list: @entity734 :: ('MESH:D019966', 'Disease') :: ['ACDs', 'Anticancer drugs']

answer: @entity786 :: (MESH:D003520,Chemical) :: ['cyclophosphamide']


abstract: INTRODUCTION: @entity259 is the most common endocrine malignancy. In childhood, @entity259 usually behaves aggressively and relapses frequently. Nevertheless, it has a favorable prognosis. Our aim is to present our experience with pediatric @entity259 ( @entity259 ) treated at the Portuguese Institute of Oncology in Lisbon (L-PIO), between 1964 and 2006. METHODS: Review of clinical files of @entity259 in <=18-year-old @entity1 selected from the databases of the Endocrinology Service of L-PIO and the South Portugal Regional Cancer Registry (SPCR). RESULTS: 93 cases of @entity259 were found. Of these, 70 (75.3%) were @entity1 . The median age was 15 years old (range 5-18) with a median follow-up time of 15.1 years (range 0.2-47.8). The most common histological diagnosis was @entity1377 of the classical variant (n=60, 64.5%). Initial @entity5 showed locoregional dissemination in 27 (29.0%) @entity1 and distant @entity3 in 16 (17.2%) @entity1 . Median age was lower in @entity1 with distant disease than in @entity1 with @entity66 or with disease confined to the thyroid (P=0.007). After the initial treatment, 44 (47.3%) @entity1 were in remission and 46 (49.5%) had persistent disease (lost follow-up in 3). Of the disease-free @entity1 after initial treatment, 11 (25.0%) relapsed later. At the last observation, most @entity1 (n=63, 67.7%) showed no evidence of disease. CONCLUSION: Our study demonstrates that @entity1 with distant metastatic disease are younger than @entity1 with a @entity146 . However, in both groups the response to treatment is favorable and the prognosis is usually excellent.

title: Review of clinical and pathological features of 93 cases of XXXX in pediatric age at the Lisbon Centre of the Portuguese Institute of Oncology between 1964 and 2006.

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'patients', 'girls']

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinoma']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['locoregional disease']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['less aggressive disease']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['staging']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastasis']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['well-differentiated thyroid carcinoma', 'Thyroid carcinoma', 'thyroid carcinoma', 'WDTC']

answer: @entity259 :: (MESH:D013964,Disease) :: ['well-differentiated thyroid carcinoma']


abstract: Several prospective studies with @entity189 as endpoint have supported @entity1082 as a cause of @entity2622 . However, the largest study used seroepidemiology and did not analyse presence of @entity1082 DNA in the subsequent @entity5 . Linkage of serum bank registries and @entity5 registries had identified 196 @entity1 with a registered @entity2622 after donation of a serum sample. For the present study, biopsies for 127 cases could be located, verified to contain @entity189 and be amplified by PCR. Three control @entity1 who had remained alive and without @entity2622 during an equal length of follow-up had been matched to each of the case @entity1 and tested for HPV antibodies. Presence of @entity1082 DNA in the @entity5 was analysed by general primer and type specific PCR. @entity1799 -seropositive @entity1 had a relative risk of 4.4 (95% CI: 2.2-8.8) to develop @entity2622 carrying @entity1799 DNA. By contrast, there was no excess risk for @entity1799 -seropositive @entity1 to develop @entity2622 devoid of @entity1799 DNA. Prediagnostic @entity1799 seropositivity was strongly correlated with later @entity1799 DNA positivity of the @entity5 (P<0.001) and prediagnostic HPV18 seropositivity correlated with HPV18 DNA in the @entity5 (P<0.03). The link between prediagnostic seropositivity and type of viral DNA in the @entity5 implies that the carcinogenic effect of infection with these viruses is dependent on persistent presence of type-specific viral DNA.

title: A prospective study of the relationship between prediagnostic @entity1082 seropositivity and HPV DNA in subsequent cervical XXXX .

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer', 'tumours', 'tumour']

entities_list: @entity2622 :: ('MESH:D002583', 'Disease') :: ['cervical carcinoma']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['invasive carcinoma']

entities_list: @entity1799 :: ('333760', 'Species') :: ['HPV16', 'Human Papillomavirus 16']

entities_list: @entity1082 :: ('10566', 'Species') :: ['Human Papillomavirus']

answer: @entity189 :: (MESH:D002277,Disease) :: ['carcinomas']


abstract: @entity1141 in @entity355 has been recognized to be morphologically heterogenous, featuring adenomatous, foveolar, and hybrid phenotypes. Recent studies have suggested a @entity5 suppressor role for @entity6628 in the @entity189 sequence. The phenotypic stability and role of @entity6628 in the @entity5 progression of different types of @entity1141 have not been evaluated. Thirty-eight endoscopic mucosal resections with @entity1141 and/or @entity189 ( @entity189 ) arising in @entity355 were evaluated for the expression of @entity5089 , @entity21826 , @entity5091 , @entity2282 , and @entity6628 . The background mucosa was also evaluated. The results were correlated with morphologic classification and clinicopathologic parameters. Of 38 endoscopic mucosal resections, 23 had @entity189 and @entity1141 , 8 had @entity189 only, and 7 had @entity1141 only. Among @entity75 , 73% were foveolar, 17% were adenomatous, and 10% were hybrid. Twenty of 23 cases with @entity1141 and adjacent @entity189 showed an identical immunophenotype of @entity1141 and @entity189 comprising 16 gastric, 3 intestinal, and 1 mixed immunophenotype. Three cases showed discordance of @entity1141 and @entity189 immunophenotype. These findings suggest that most Barrett-related @entity189 cases are either gastric or intestinal, with phenotypic stability during progression supporting separate gastric and intestinal pathways of @entity105 . @entity6628 showed gradual downregulation of expression during progression in @entity1412 but not in foveolar or hybrid @entity1141 , supporting a @entity5 suppressor role, at least in the intestinal pathway. @entity6628 was also found to be expressed to a greater degree in @entity1944 compared with nonintestinalized columnar metaplasia. Consistent with @entity6628 as a @entity5 suppressor, this suggests that nonintestinalized columnar metaplasia may be an unstable intermediate state at risk for @entity5 progression.

title: Divergent expression of @entity5089 , @entity21826 , @entity5091 , @entity2282 , and XXXX in @entity1141 and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to @entity105 in @entity355 ?

entities_list: @entity1944 :: ('MESH:D007410', 'Disease') :: ['intestinal metaplasia']

entities_list: @entity355 :: ('MESH:D001471', 'Disease') :: ['Barrett esophagus']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'neoplastic']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['dysplastic lesions']

entities_list: @entity1412 :: ('MESH:D011125', 'Disease') :: ['adenomatous dysplasia']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['intramucosal carcinoma', 'IMC', 'metaplasia-dysplasia-carcinoma']

entities_list: @entity105 :: ('MESH:D063646', 'Disease') :: ['carcinogenesis']

entities_list: @entity1141 :: ('MESH:C535662', 'Disease') :: ['dysplasia', 'Dysplasia', 'dysplasias']

answer: @entity6628 :: (1045,Gene) :: ['CDX-2']


abstract: OBJECTIVE: To assess the frequency and significance of @entity37345 infection in type 1 @entity775 . MATERIAL AND METHODS: Serum specimens from 94 @entity1 with type 1 @entity775 were tested for @entity37345 RNA by reverse transcription and polymerase chain reaction. Serum samples from 50 normal subjects were also assessed. RESULTS: Three of the 94 specimens from @entity1 with @entity775 were positive for @entity37345 RNA in comparison with none of the 50 control samples (3% versus 0%; P = 0.5). Two @entity1 were seropositive after @entity548 and blood transfusion, including one @entity1 who clearly acquired the infection in this fashion. One @entity1 had no epidemiologic basis for his seropositivity. @entity646 was prolonged in all infected @entity1 (mean duration, 69 +/- 23 months; range, 36 to 113); however, no clinical features suggested a concurrent @entity1800 , and mortality was similar to that among the uninfected counterparts (33% versus 8%; P = 0.2). Liver transplantation was more common in the infected @entity1 (67% versus 9%; P = 0.03), but the duration of disease was also longer in these @entity1 (277 +/- 29 months versus 106 +/- 9 months; P = 0.0008). Clinical features and immediate responses to @entity228 therapy were similar in both groups. CONCLUSION: @entity37345 RNA is found infrequently in type 1 @entity775 , and @entity37345 is unlikely to be an important etiologic agent or prognostic determinant.

title: XXXX infection in type 1 @entity775 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['variceal hemorrhage']

entities_list: @entity228 :: ('CHEBI:50858', 'Chemical') :: ['corticosteroid']

entities_list: @entity1800 :: ('MESH:D014777', 'Disease') :: ['viral infection']

entities_list: @entity775 :: ('MESH:D019693', 'Disease') :: ['autoimmune hepatitis']

answer: @entity37345 :: (54290,Species) :: ['GB virus-C']


abstract: The authors present two cases of primary @entity1492 ( @entity1492 ) of the kidney. Both @entity1 had a mass in the upper part of the left kidney without any primary @entity1313 . Grossly, the @entity5 were solid masses both measuring 7.5  cm in the greatest diameter. Histologically, one of the lesions exhibited a predominantly lobular growth of round or oval small uniform epithelioid cells in variable cellularity. Circular zones of crowded @entity5 cells alternating with hypocellular collagenous tissue in a concentric fashion around entrapped native renal tubules were distinctive. The second case was distinctive with significant cytological atypia in the neoplastic cells and prominent reactive proliferations in the trapped renal tubules. Immunohistochemically, @entity2277 , @entity588 and @entity5088 were diffusely positive in both. They were negative for @entity2281 protein, @entity2280 , and desmin, whereas @entity3778 were positive in one lesion. Fluorescence in situ hybridization assay using dual staining probes detected @entity12726 - @entity12522 fusion in each lesion, which is characteristic molecular findings of @entity1492 . One @entity1 presented widespread distant metastases at the time of diagnosis. In the other, no @entity5 deposits were detected other than primary. Both @entity1 have been alive with 30 and 10  month follow-ups, respectively. These @entity5 are 6th and 7th cases of primary renal @entity1492 in the literature confirmed by FISH study, which exhibit unique and remarkable histomorphologic features.

title: Primary XXXX of kidney with variant histomorphologic features: report of 2 cases and review of the literature.

entities_list: @entity1313 :: ('MESH:D001932', 'Disease') :: ['extrarenal neoplastic lesions']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'tumors']

entities_list: @entity1492 :: ('MESH:D005354', 'Disease') :: ['SEF', 'sclerosing epithelioid fibrosarcoma']

answer: @entity1492 :: (MESH:D005354,Disease) :: ['sclerosing epithelioid fibrosarcoma']


abstract: OBJECTIVE: @entity1 with @entity161 have increased risk of @entity731 . It is already known that lifestyle-related disorders and the use of antipsychotics are closely related with the progression of @entity731 in @entity146 @entity1 . @entity64 as well as @entity301 play an important role in the cause of @entity204 in Asia and Japan. Thus, we studied the prevalence of @entity66 in @entity146 inpatients in Japan using brain magnetic resonance imaging (MRI). METHOD: This cross-sectional study was performed from January 2012 to December 2013. Study @entity1 were 152 hospitalized @entity1 (61 @entity1 and 91 @entity1 ) in the Department of Psychiatry at Kohnodai Hospital, National Center for Global Health and Medicine, Ichikawa City, Japan. Mean ages were 50.0 and 57.1 years old for @entity1 and @entity1 , respectively. The diagnoses (DSM-IV-TR criteria) of @entity1 were @entity161 (69.1%), @entity1316 (18.4%), and other @entity146 (12.5%). We checked physical status, metabolic status of @entity413 and lipid levels, and brain MRI within 1 week of admission. RESULTS: The study group showed a significantly high prevalence of @entity6 and low high-density lipoprotein (HDL) cholesterolemia in both sexes (n = 61 in @entity1 , n = 91 in @entity1 , P < .05). In the study group, serum fasting plasma @entity413 and hemoglobin A1c levels were significantly high (n = 152, P < .05), but serum HDL @entity165 and total @entity165 were significantly low in both sexes (n = 61 in @entity1 , n = 90 in @entity1 , P < .05), and @entity1674 were low in @entity1 (n = 61, P < .05). Silent @entity4798 was recognized at a higher rate (n = 98, P < .05) compared with healthy controls. CONCLUSIONS: @entity1 in this study had an increased ratio of silent @entity4798 compared with Japanese healthy controls, accompanied with higher ratios of @entity6 and low HDL @entity165 .

title: Increased Silent Brain Infarction Accompanied With High Prevalence of XXXX and Dyslipidemia in @entity146 Inpatients: A Cross-Sectional Study.

entities_list: @entity1 :: ('9606', 'Species') :: ['Participants', 'men', 'women', 'Patients', 'participants', 'patients']

entities_list: @entity4798 :: ('MESH:D020520', 'Disease') :: ['brain infarction']

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['cerebrovascular disease']

entities_list: @entity6 :: ('MESH:D003920', 'Disease') :: ['diabetes']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['psychiatric', 'mental disorders']

entities_list: @entity301 :: ('MESH:D003327', 'Disease') :: ['coronary heart disease']

entities_list: @entity1674 :: ('MESH:D014280', 'Chemical') :: ['triglycerides']

entities_list: @entity1316 :: ('MESH:D019964', 'Disease') :: ['mood disorder']

entities_list: @entity161 :: ('MESH:D012559', 'Disease') :: ['schizophrenia']

entities_list: @entity731 :: ('MESH:D050197', 'Disease') :: ['atherosclerotic diseases', 'atherosclerosis']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

answer: @entity6 :: (MESH:D003920,Disease) :: ['Diabetes']


abstract: The antinociceptive effect of alpha(2)-adrenoceptor agonists is mediated by activation of descending inhibiting noradrenergic systems, which modulates 'wide-dynamic-range' neurones. Furthermore, they inhibit the liberation of @entity4757 and endorphines and activate serotoninergic neurones. Despite this variety of antinociceptive actions, there is still little experience with alpha(2)-adrenoceptor agonists as therapeutic agents for use in @entity1118 syndromes. Studies in animals and @entity1 have shown that the transdermal, epidural and intravenous administration of the alpha(2)-adrenoceptor agonist @entity1338 reduces @entity158 intensity in @entity9 syndromes for periods varying from some hours up to 1 month. @entity1 suffering from lancinating or sharp @entity158 respond best to this therapy. Topically applied @entity1338 (200-300 microg) relieves @entity1931 in sympathetically maintained @entity158 . Epidural administration of 300 microg @entity1338 dissolved in 5 ml @entity1219 0.9 % has also been shown to be effective. In @entity1 suffering from @entity5 tolerant to opioids, @entity158 control has proved possible again with combinations of opioids and @entity1338 . In isolated cases @entity1338 has been administered epidurally at a dose of 1500 microg/day for almost 5 months without evidence for any histotoxic property of @entity1338 . Side effects often observed during administration of alpha(2)-adrenoceptor agonists are @entity2133 , sedation, @entity551 and @entity1168 . Therapeutic interventions are usually not required.

title: [Alpha 2-adrenoceptor agonists for the treatment of XXXX ].

entities_list: @entity1 :: ('9606', 'Species') :: ['Patients', 'patients']

entities_list: @entity1931 :: ('MESH:D006930', 'Disease') :: ['hyperalgesia']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer pain']

entities_list: @entity1168 :: ('MESH:D001919', 'Disease') :: ['bradycardia']

entities_list: @entity551 :: ('MESH:D007022', 'Disease') :: ['hypotension']

entities_list: @entity1338 :: ('MESH:D003000', 'Chemical') :: ['clonidine']

entities_list: @entity1118 :: ('MESH:D059350', 'Disease') :: ['chronic pain']

entities_list: @entity9 :: ('MESH:D009437', 'Disease') :: ['neuropathic pain']

answer: @entity1118 :: (MESH:D059350,Disease) :: ['chronic pain']


abstract: OBJECTIVE: Orbital complications of acute @entity1244 can be severe. Nowadays, surgical drainage of intraorbital abscess formations is performed endoscopically in the majority of cases. This study aims to illustrate the Graz experience in the endoscopic treatment of orbital complications and to present our treatment algorithm. METHODS: In a retrospective study, 53 @entity1 were examined who were referred to the Department of General Otorhinolaryngology of the ENT-University Hospital Graz from 2000 to 2011. RESULTS: Of 53 @entity1 , @entity1 were affected more frequently than @entity1 (n = 37, 69.81% vs n = 16, 30.19%). The following diagnoses were obtained: 9 @entity2688 , 7 @entity4550 , 14 subperiosteal @entity733 , and 23 orbital @entity733 . In 16 @entity1 , a conservative therapy was administered; 37 @entity1 underwent surgery, most of them purely endoscopically (n = 31, 83.78%). Two of the @entity1 who underwent conservative treatment and 7 of those who underwent surgery experienced a recurrence (n = 9, 16.98%). CONCLUSION: Based on analysis of our recurrences, we have tried to create the optimal treatment algorithm as a point of reference in the management of orbital complications of acute @entity1244 . In this way, 7 of 9 recurrences could have been avoided, equaling a hypothetical recurrence rate of 3.77% instead of 16.98% (hypothetical success rate 96.23%).

title: Transnasal Endoscopic Treatment of Orbital Complications of Acute XXXX : The Graz Concept.

entities_list: @entity1244 :: ('MESH:D012852', 'Disease') :: ['sinusitis']

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'men']

entities_list: @entity2688 :: ('MESH:D002481', 'Disease') :: ['preseptal cellulitis']

entities_list: @entity733 :: ('MESH:D000038', 'Disease') :: ['abscesses']

entities_list: @entity4550 :: ('MESH:D054517', 'Disease') :: ['orbital cellulitis']

answer: @entity1244 :: (MESH:D012852,Disease) :: ['Sinusitis']


abstract: BACKGROUND: Colorectal resection is performed in a majority of @entity1 presenting with large @entity46 of mid and lower rectum; however, it may negatively and irreversibly impact postoperative rectal function. To avoid such unfavourable outcomes, we propose an original technique combining laparoscopic deep rectal shaving and transanal disc excision using a semi-circular stapler. METHODS: The video presents the procedure performed in a 29-year-old nullipara referred with a large endometriotic nodule infiltrating the lower rectum on more than 30  mm length. The first step is laparoscopic and involves deep rectal shaving performed using exclusively the plasma energy. Then, transanal excision of shaved area is performed, by placing traction parachute sutures in the middle and outside the shaved area. Their traction induces the prolapse of shaved area that is resected using a semicircular stapler. Insufflating the rectum with air checks the integrity of the staple line. RESULTS: Operative time was 210  min. Immediate postoperative outcomes were uneventful, and bowel movements were normal beginning with day 6. Our technique is suitable in large rectal nodules located up to 10  cm above the anus, infiltrating the rectum on up to 6  cm length, and these parameters are preoperatively assessed using MRI and computed tomography. To date, it was successfully carried out in 29 @entity1 with large deep @entity46 of the mid and lower rectum. @entity3622 was recorded in one @entity1 (3.6  %) and transitory @entity1494 in seven @entity1 (25  %). Digestive function assessment using standardized questionnaires revealed an overall improvement, without de novo anal continence troubles. Postoperative pregnancy rate was 78  % with a majority of @entity1 having conceived spontaneously. CONCLUSIONS: Based on our experience, we believe that our conservative technique is feasible and reproducible in large mid and lower @entity46 and might avoid the risk of unfavourable outcomes related to low colorectal resection.

title: Deep shaving and transanal disc excision in large XXXX of mid and lower rectum: the Rouen technique.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'patient']

entities_list: @entity46 :: ('MESH:D004715', 'Disease') :: ['endometriosis', 'rectal endometriosis']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['bladder dysfunction']

entities_list: @entity3622 :: ('MESH:D012006', 'Disease') :: ['Rectovaginal fistula']

answer: @entity46 :: (MESH:D004715,Disease) :: ['endometriosis']


abstract: New crown-appended @entity165 -based organogelator 1, which has two @entity165 skeletons as a chiral aggregate-forming site, two @entity1472 groups as an acidic proton-binding site, and one crown moiety as a cation-binding site, was synthesized, and the gelation ability was evaluated in organic solvents. It can gelate @entity1543 , @entity1626 , @entity1324 , @entity1068 , @entity10439 , @entity9840 , @entity3733 , and @entity9104 under 1.0 wt %, indicating that 1 acts as a versatile gelator of various organic solvents. To characterize the aggregation mode in the organogel system, we observed a CD spectrum of the @entity1543 gel 1. In the CD spectrum, the lambda(theta)=0 value appears at 353 nm, which is the same as the absorption maximum lambda(max) = 353 nm. The positive sign for the first @entity2708 effect indicates that the dipole moments of @entity37313 chromophores tend to orient in a clockwise direction. Very surprisingly, the TEM images of the 1 + @entity1543 gel resulted in the helical ribbon and the tubular structures. @entity4625 -gel polymerization of @entity23149 was carried out using 1 in the gel phase. The @entity3440 obtained from the 1 + @entity1543 gel showed the helical ribbon with 1700-1800-nm pitches and the tubular structure of the @entity3440 with approximately 560-nm outer diameter. As far as can be recognized, all the helicity possesses a right-handed helical motif. Since the exciton-coupling band of the organogel also shows R (right-handed) helicity, we consider that a microscopic helicity is reflected by a macroscopic helicity.

title: Helical ribbon aggregate composed of a crown-appended XXXX derivative which acts as an amphiphilic gelator of organic solvents and as a template for chiral @entity3440 transcription.

entities_list: @entity37313 :: ('MESH:C009850', 'Chemical') :: ['azobenzene']

entities_list: @entity1626 :: ('MESH:C032159', 'Chemical') :: ['acetonitrile']

entities_list: @entity1543 :: ('MESH:D019342', 'Chemical') :: ['acetic acid']

entities_list: @entity165 :: ('MESH:D002784', 'Chemical') :: ['cholesterol']

entities_list: @entity23149 :: ('MESH:C040733', 'Chemical') :: ['tetraethoxysilane']

answer: @entity165 :: (MESH:D002784,Chemical) :: ['cholesterol']


abstract: BACKGROUND: @entity460 disorders are common in both intensive care units and in @entity1 with @entity740 and are associated with increased morbidity and mortality. It is unknown whether @entity460 abnormalities in unselected emergency department admissions have an impact on in-hospital mortality. METHODS: This cross-sectional analysis included all admissions to the Emergency Department at the Inselspital Bern, Switzerland from 2010 to 2011. For hyper- and hypocalcaemic @entity1 with a Mann-Whitney U-test, the differences between subgroups divided by age, length of hospital stay, @entity1011 , @entity1372 , @entity2865 , @entity4613 , @entity972 and @entity1760 were compared. Associations between @entity460 disorders and 28-day in-hospital mortality were assessed using the Cox proportional hazard regression model. RESULTS: 8,270 @entity1 with @entity460 measurements were included in our study. Overall 264 (3.2%) @entity1 died. 150 @entity1 (6.13%) with hypocalcaemia and 7 @entity1 with hypercalcaemia (6.19%) died, in contrast to 104 normocalcaemic @entity1 (1.82%). In univariate analysis, @entity460 serum levels were associated with sex, mortality and pre-existing diuretic therapy (all p<0.05). In multivariate Cox regression analysis, hypocalcaemia and hypercalcaemia were independent risk factors for mortality (HR 2.00 and HR 1.88, respectively; both p<0.01). CONCLUSION: Both hypocalcaemia and hypercalcaemia are associated with increased 28-day in-hospital mortality in unselected emergency department admissions.

title: XXXX Disorders in the Emergency Department: Independent Risk Factors for Mortality.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity972 :: ('MESH:D011188', 'Chemical') :: ['potassium']

entities_list: @entity740 :: ('MESH:D051436', 'Disease') :: ['chronic kidney disease']

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium', 'Calcium']

entities_list: @entity2865 :: ('CHEBI:17996', 'Chemical') :: ['chloride']

entities_list: @entity1011 :: ('MESH:D003404', 'Chemical') :: ['creatinine']

entities_list: @entity1760 :: ('MESH:D008274', 'Chemical') :: ['magnesium']

answer: @entity460 :: (MESH:D002118,Chemical) :: ['Calcium']


abstract: OBJECTIVES: We evaluated the effects of irradiation, @entity632 and @entity619 on @entity1 @entity263 cells, investigating whether @entity619 and @entity632 can alter the irradiation cytotoxicity of PC-3 cells. METHODS: We used the @entity1 @entity263 cells, analyzing cell growth with @entity3460 exclusion, indices of the cell cycle with flow cytometry and apoptosis with flow cytometry and analysis of DNA fragmentation on simple agarose gel. RESULTS: @entity632 (100 nM) arrested cell cycle at the G2/M phase, decreased cell growth and produced apoptosis of PC-3 cells in a time-dependent manner. @entity619 (100 nM) increased the distribution of PC-3 cells at G0/G1 phase in the cell cycle, exerting an inhibitory effect on the proliferation of PC-3 cells after 48 and 72 hr, but it did not produce apoptosis. Irradiation (4 Gy) initially arrested cells at the G2/M phase in the cell cycle (24 hr) which was gradually overcome and the PC-3 cells were shifted into G0/G1 phase or apoptosis after 48 and 72 hr. Irradiation decreased the PC-3 cell growth by 40-50% after 48 and 72 hr, respectively. Treatment with @entity632 (100 nM) for 24, 48, and 72 hr after irradiation potentiated irradiation cytotoxicity of PC-3 cells. @entity619 treatment 24 hr before and 24, 48 and 72 hr after irradiation increased the number of surviving PC-3 cells and partially neutralized the irradiation effects on cell cycle. CONCLUSION: @entity632 potentiated while @entity619 partially reversed the irradiation cytotoxicity of PC-3 cells. These data may be of clinical importance for the treatment of hormone @entity263 .

title: Response of @entity263 cells to combination therapy using irradiation with glucocorticoids or XXXX .

entities_list: @entity632 :: ('MESH:D004317', 'Chemical') :: ['doxorubicin', 'Doxorubicin']

entities_list: @entity263 :: ('MESH:D011471', 'Disease') :: ['refractory prostate cancer', 'PC-3 prostate cancer']

entities_list: @entity619 :: ('MESH:D003907', 'Chemical') :: ['Dexamethasone', 'dexamethasone']

entities_list: @entity3460 :: ('MESH:D014343', 'Chemical') :: ['trypan blue']

answer: @entity632 :: (MESH:D004317,Chemical) :: ['doxorubicin']


abstract: INTRODUCTION: @entity370 is a multisystemic @entity738 disease of unknown aetiology. Neurologic manifestations are found in 5 to 10% of cases. @entity1 AND METHODS: We conducted a retrospective study over 6-year period including 18  @entity1 diagnosed with @entity7993 in the Neurologic department of the Military Hospital of Instruction of Tunis. Clinical, radiological, therapeutic features and outcome were studied. RESULTS: The mean age was 43.44  years. Neurologic signs were the first symptom in 10  cases. @entity1897 was often found. @entity693 was noted in 8  cases. Biological tests are not contributive for the diagnosis. The brain magnetic resonance imaging was pathologic in 10  cases. Corticosteroids were administrated in the majority of cases. Eight @entity1 did not show any sign of improvement. Ten cases improved with treatment. DISCUSSION AND CONCLUSION: Diagnosis of @entity7993 is difficult because of its clinical and radiological polymorphism. It is based on a clinical history suggestive of @entity7993 , laboratory, imaging and histological studies.

title: [Neurologic manifestations of XXXX : A study of 18  cases].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomatous']

entities_list: @entity693 :: ('MESH:D008581', 'Disease') :: ['Meningitis']

entities_list: @entity1897 :: ('MESH:D010523', 'Disease') :: ['Peripheral nervous system impairment']

entities_list: @entity7993 :: ('MESH:C535814', 'Disease') :: ['neurosarcoidosis']

entities_list: @entity370 :: ('MESH:D012507', 'Disease') :: ['Sarcoidosis']

answer: @entity370 :: (MESH:D012507,Disease) :: ['sarcoidosis']


abstract: AIM: To compare the efficacy of antibiotics therapy alone with antibiotics and @entity375 boulardii in treatment of acute @entity8016 . METHODS: In a double blind, random clinical trial on @entity1 with @entity16126 , 57 adult @entity1 with acute @entity8016 , diagnosed with clinical manifestations ( @entity697 ) and amebic trophozoites engulfing RBCs found in stool were enrolled in the study. Regimen 1 included @entity868 (750 mg Tid) and @entity70446 (630 mg Tid) for 10 days. Regimen 2 contained capsules of lyophilized @entity375 boulardii (250 mg Tid) orally in addition to regimen 1. @entity1 were re-examined at two and four weeks after the treatment, and stool examination was performed at the end of week 4. Student's t-test, chi(2) and McNemar's tests were used for statistical analysis. RESULTS: Three @entity1 refused to participate. The other 54 @entity1 were randomized to receive either regimen 1 or regimen 2 (Groups 1 and 2 respectively, each with 27 @entity1 ). The two groups were similar regarding their age, sex and clinical manifestations. In Group 1, @entity294 lasted 48.0+/-18.5 hours and in Group 2, 12.0+/-3.7 hours (P<0.0001). In Group 1, the durations of @entity221 and @entity490 were 24.0+/-8.8 and 24.0+/-7.3 hours and in Group 2 they were 12.0+/-5.3 and 12.0+/-3.2 hours, respectively (P<0.001). Duration of @entity10 was similar in both groups. At week 4, amebic cysts were detected in 5 cases (18.5 %) of Group 1 but in none of the Group 2 (P<0.02). CONCLUSION: Adding @entity375 boulardii to antibiotics in the treatment of acute @entity8016 seems to decrease the duration of clinical symptoms and cyst passage.

title: Efficacy of XXXX boulardii with antibiotics in acute @entity8016 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'Patients']

entities_list: @entity697 :: ('MESH:D000208', 'Disease') :: ['acute mucous bloody diarrhea']

entities_list: @entity868 :: ('MESH:D008795', 'Chemical') :: ['metronidazole']

entities_list: @entity70446 :: ('MESH:D004103', 'Chemical') :: ['iodoquinol']

entities_list: @entity294 :: ('MESH:D003967', 'Disease') :: ['diarrhea']

entities_list: @entity16126 :: ('MESH:D004404', 'Disease') :: ['acute intestinal amoebiasis']

entities_list: @entity10 :: ('MESH:D006261', 'Disease') :: ['headache']

entities_list: @entity8016 :: ('MESH:D000562', 'Disease') :: ['amebiasis', 'amoebiasis']

entities_list: @entity490 :: ('MESH:D015746', 'Disease') :: ['abdominal pain']

entities_list: @entity375 :: ('4932', 'Species') :: ['saccharomyces']

answer: @entity375 :: (4932,Species) :: ['saccharomyces']


abstract: PURPOSE: Ictal motor phenomena play a crucial role in the localization of @entity410 focus in the management of refractory focal @entity302 . While the importance of unilateral @entity10804 is well established, little attention is paid to the contralateral relatively immobile limb. In cases where @entity10804 mimic @entity42385 and in the absence of previously well-established signs, unilateral relative ictal immobility (RII) is potentially useful as a lateralizing sign. This study was carried out to examine the lateralizing value of this sign and to define its characteristics among @entity1 of refractory focal @entity302 . METHODS: VEEGs of 69 consecutive @entity1 of refractory focal @entity302 who had undergone @entity302 surgery at our center over last four years were reviewed and analyzed for the presence of RII. Unilateral RII was defined as a paucity of movement in one limb lasting for at least 10s while the contralateral limb showed @entity717 (in the absence of @entity3520 or clonic movements in the involved limb). The findings were seen in the light of VEEG, radiological and nuclear imaging data, and with post-surgical outcome. RESULTS: Unilateral RII as a lateralizing sign was found in 24 of 69 @entity1 (34.78%), consisting of both temporal and extra @entity25474 , with 100% concordance with VEEG and MRI data. All @entity1 demonstrating this sign had a good post-surgical outcome. CONCLUSION: RII, when well characterized is a frequent and reliable lateralizing sign in @entity1 of refractory focal @entity302 .

title: Lateralizing value of unilateral relative ictal immobility in @entity1 with refractory focal XXXX - Looking beyond unilateral @entity10804 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity3520 :: ('MESH:D020821', 'Disease') :: ['tonic or dystonic posturing']

entities_list: @entity25474 :: ('MESH:C536956', 'Disease') :: ['temporal epilepsy']

entities_list: @entity42385 :: ('MESH:C536300', 'Disease') :: ['clonic or dystonic movements']

entities_list: @entity10804 :: ('MESH:C537069', 'Disease') :: ['automatisms']

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity717 :: ('MESH:D009069', 'Disease') :: ['purposive or semi-purposive movements']

answer: @entity410 :: (MESH:D012640,Disease) :: ['seizures']


abstract: BACKGROUND: SIAscopy (Spectrophotometric Intracutaneous Analysis) enables non-invasive analysis of the skin. OBJECTIVE: We wanted to determine whether SIAscopy is able to detect and differentiate the skin chromophores melanin, collagen and haemoglobin and the influence of immunosuppressive drugs and other known risk factors for @entity1489 ( @entity1489 ). METHODS: Volunteers and @entity1 were measured by SIAscopy at six spots on sun-exposed and two spots on sun-protected skin. Measurements were transformed by SIAmetrics into arbitrary units and statistically analysed. RESULTS: Melanin was shown to be higher with age (+1.73759  a.u.; P  <  0.0001), sun exposure (+47.03998 a.u.; P  <  0.0001), immunosuppression (+10.48526  a.u.; P  <  0.0001) and lower in males (-26.50952 a.u.; P  <  0.0001). Collagen was lower with increasing age (-0.29162 a.u.; P  <  0.0001) and sun exposure (-6.85586  a.u.; P  <  0.0001) but higher with male sex (+8.34251  a.u.; P  <  0.0001) and immunosuppression (+5.79171  a.u.; P  =  0.0001). Haemoglobin was lower with increasing age (-0.23833  a.u.; P  =  0.0005), but higher with male sex (+18.51976  a.u.; P  <  0.0001) and sun exposure (+13.74523  a.u.; P  <  0.0001). Haemoglobin content was not associated to immunosuppression. CONCLUSION: Our results encourage the use of SIAscopy as a tool to better gauge an individual @entity1 's @entity1489 risk factors. Further studies should help to better delineate SIAscopy as a prognostic tool.

title: Spectophotometric intracutaneous analysis: an investigation on photodamaged skin of immunocompromised XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity1489 :: ('MESH:D012878', 'Disease') :: ['non-melanoma skin cancer', 'NMSC']

answer: @entity1 :: (9606,Species) :: ['patients']


abstract: BACKGROUND: @entity726 combined with an extremely @entity231 remains as a complex condition to deal with. And the emergence of microincision vitrectomy surgery (MIVS) system may provide an ideal option for the treatment of that. We report a clinical study of surgical outcomes of 23-gauge transconjunctival pars plana vitrectomy ( @entity2286 ) combined with lensectomy in the treatment of @entity735 with extremely shallow anterior chamber and @entity231 . METHODS: Prospective, nonrandomized and noncomparative case series study. Consecutive @entity1 with @entity726 , extremely shallow anterior chamber and @entity231 were recruited to have combined surgeries of 23-gauge transconjunctival pars plana vitrectomy and lensectomy. The main outcomes were best corrected visual acuity (BCVA), intraocular pressure (IOP), @entity8707 ( @entity8707 ), number of anti- @entity726 medications and surgery-associated complications. RESULTS: Seventeen consecutive @entity1 with @entity726 , extremely shallow anterior chamber and @entity231 were recruited. The mean follow-up was 21.2        8.8  months. Postoperatively, there was no significant improvement of BCVA (P   =   0.25). The mean intraocular (IOP) decreased significantly from 43.14        6.53  mmHg to 17.29        1.80  mmHg (P   <   0.001), and the mean depth of anterior chamber increased significantly from 0.507        0.212  mm to 3.080        0.313  mm (P   <   0.001). The mean number of anti- @entity726 medications decreased from 4.1        0.8 to 0.6        0.8 (P   <   0.001). No severe vision-threatening intra- or post-operative complications occurred. CONCLUSIONS: @entity726 with an extremely shallow anterior chamber and @entity231 can be managed well with the combined surgeries of 23-gauge pars plana vitrectomy and lensectomy. The surgical procedure is an effective and safe method to resolve the @entity616 and deepen the anterior chamber.

title: Surgical outcomes of 23-gauge transconjunctival pars plana vitrectomy combined with lensectomy for @entity735 with extremely shallow anterior chamber and XXXX .

entities_list: @entity231 :: ('MESH:D002386', 'Disease') :: ['cataract', 'shallow anterior chamber and cataracts']

entities_list: @entity8707 :: ('MESH:C535679', 'Disease') :: ['ACD', 'anterior chamber depth']

entities_list: @entity726 :: ('MESH:D005901', 'Disease') :: ['Glaucoma', 'secondary glaucoma', 'glaucoma']

entities_list: @entity735 :: ('MESH:D005124', 'Disease') :: ['glaucomatous eyes']

entities_list: @entity616 :: ('MESH:D006327', 'Disease') :: ['pupillary block']

answer: @entity231 :: (MESH:D002386,Disease) :: ['cataract']


abstract: Snake venoms are mixtures of bioactive proteins and peptides that exhibit diverse biochemical activities. This wide array of pharmacologies associated with snake venoms has made them attractive sources for research into potentially novel therapeutics, and several venom-derived drugs are now in use. In the current study we performed a broad screen of a variety of venoms (61 taxa) from the major @entity5900 families (Viperidae, Elapidae and "Colubridae") in order to examine cytotoxic effects toward MCF-7 @entity0 cells and A-375 @entity320 cells. @entity98 cell viability assays of @entity5 cells incubated with crude venoms revealed that most venoms showed significant @entity137 . We further investigated venom from the Red-bellied Blacksnake (Pseudechis porphyriacus); venom was fractionated by ion exchange fast protein liquid chromatography and several cytotoxic components were isolated. @entity214 -PAGE and MALDI-TOF mass spectrometry were used to identify the compounds in this venom responsible for the cytotoxic effects. In general, viper venoms were potently cytotoxic, with MCF-7 cells showing greater sensitivity, while elapid and colubrid venoms were much less toxic; notable exceptions included the elapid genera Micrurus, Naja and Pseudechis, which were quite cytotoxic to both cell lines. However, venoms with the most potent @entity137 were often not those with low @entity19 LD50s, including some dangerously venomous viperids and Australian elapids. This study confirmed that many venoms contain cytotoxic compounds, including catalytic @entity7098 , and several venoms also showed significant differential @entity137 toward the two @entity5 cell lines. Our results indicate that several previously uncharacterized venoms could contain promising lead compounds for drug development.

title: Evaluation of cytotoxic activities of snake XXXX (A-375) cell lines.

entities_list: @entity137 :: ('MESH:D064420', 'Disease') :: ['toxicity', 'cytotoxicity']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['cancer']

entities_list: @entity320 :: ('MESH:D008545', 'Disease') :: ['melanoma']

entities_list: @entity5900 :: ('MESH:D012909', 'Disease') :: ['venomous snake']

answer: @entity0 :: (MESH:D001943,Disease) :: ['venoms toward breast (MCF-7) and skin cancer']


abstract: OBJECTIVES: To assess the effectiveness of continuous @entity11399 acupressure as an adjunct to antiemetic drug therapy in the prevention and control of @entity390 and @entity391 in the first 24h after @entity583 ( @entity583 ). DESIGN: Partially randomised, partially blinded placebo-controlled, exploratory clinical study. SETTING: Coronary Care Unit, Torbay Hospital, Torquay, Devon. @entity1 : A total of 301 consecutive @entity1 (205 males, 96 females) admitted following acute @entity583 . INTERVENTION: The first 125 @entity1 recruited received no additional intervention. Subsequent @entity1 were randomised to receive either continuous @entity11399 acupressure or placebo acupressure. OUTCOME MEASURES: (1) Incidence of @entity583 , (2) severity of symptoms, (3) use of antiemetic drugs, over 24h. RESULTS: There were no significant differences between the groups for the whole 24-h treatment period. However, the @entity11399 acupressure group experienced significantly lower incidence of @entity1209 during the last 20h (18%), compared with the placebo (32%) or control (43%) groups (P<0.05). The severity of symptoms and the need for antiemetic drugs were also reduced in the acupressure group, but these differences were not statistically significant. CONCLUSIONS: Continuous 24-h @entity11399 acupressure therapy as an adjunct to standard antiemetic medication for @entity583 is feasible and is well accepted and tolerated by @entity1 . In view of its benefits, further studies are worthwhile using earlier onset of treatment.

title: Continuous @entity11399 wristband acupressure for relief of @entity390 and XXXX associated with @entity583 : a partially randomised, placebo-controlled trial.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PARTICIPANTS']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity583 :: ('MESH:D009203', 'Disease') :: ['myocardial infarction', 'MI', 'post-MI nausea and/or vomiting', 'post-MI nausea and vomiting']

entities_list: @entity1209 :: ('MESH:D020250', 'Disease') :: ['nausea and/or vomiting']

answer: @entity391 :: (MESH:D014839,Disease) :: ['vomiting']


abstract: Chronic high frequency (130 Hz) stimulation (HFS) of the thalamic target @entity2277 , first used in our group in 1987 as a treatment of @entity400 of various origins, has been used over the last ten years in 137 @entity1 . Since 1993, this method has been extended to two other targets (subthalamic nucleus (STN): 137 @entity1 and the medial pallidum ( @entity14243 ): 12 @entity1 ), based on recent experimental data in @entity35 and monkeys. STN appears to be a target of major interest, able to control the three cardinal symptoms and to allow the decrease or suppression of levodopa treatment, which then also suppresses levodopa induced @entity910 . The stereotactic technique is based on the determination of the target using ventriculography, MRI and electrophysiology, with both microrecording of single neuron activity and microstimulation inducing therapeutic symptom suppression and side effects. Chronic electrodes are then placed bilaterally at the best physiologically defined location and then connected to implantable stimulators (either 2 Itrel II or the new double channel Kinetra), operated at 130-185 Hz, 60 ms pulse width, 2.5 to 3.5 volts. There was no operative mortality and permanent morbidity was observed in 3 @entity1 . The mechanisms of action of HFS are not fully understood, but are definitely related to high frequency and are probably different depending on the target. Inhibition of cellular activity or of neural network functions could be induced, by jamming of a retroactive loop for @entity400 , or by shutdown of neurotransmitter release in STN. Mechanisms within an individual target are also probably different for @entity400 or for other symptom alleviation. All cardinal symptoms are alleviated from @entity400 to @entity910 and @entity2003 . This strong improvement allows the decrease of the drug dosage to approximately 30% of the preoperative level, which suppresses the levodopa-induced @entity910 . The off period @entity3519 are also suppressed as well as freezings and falls. The effects remain stable over more than 5 years and in the same period, the off stimulation-off medication UPDRS remains stable and does not increase at the usual rate The low rate of permanent complications, the minor side effects and their immediate reversibility, the possibility of bilateral implantation in one session and the long-term persistence of symptom relief are strong arguments which support chronic HFS of STN as the method of choice when a surgical procedure is indicated for the treatment of @entity191 and even more when a bilateral procedure is necessary. Recent data show that STN stimulation could be useful in the treatment of @entity3519 as well as some forms of @entity302 . It is therefore possible that DBS in STN as well as in other targets could become a potent therapeutic tool in the near future for @entity16 .

title: Deep brain stimulation of the corpus luysi (subthalamic nucleus) and other targets in @entity191 . Extension to new indications such as @entity3519 and XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity16 :: ('MESH:D009422', 'Disease') :: ['neurological disorders']

entities_list: @entity910 :: ('MESH:D004409', 'Disease') :: ['dyskinesias', 'akinesia']

entities_list: @entity191 :: ('MESH:D010300', 'Disease') :: ["Parkinson's disease"]

entities_list: @entity302 :: ('MESH:D004827', 'Disease') :: ['epilepsy']

entities_list: @entity3519 :: ('MESH:D004421', 'Disease') :: ['dystonias', 'dystonia']

answer: @entity302 :: (MESH:D004827,Disease) :: ['epilepsy']


abstract: BACKGROUND/PURPOSE: Despite frequent use of percutaneous endoscopic gastrostomy ( @entity970 ) for enteral feeding, the relationship between it and @entity354 ( @entity354 ) remains an incompletely answered question. We conducted this study to compare the @entity354 between the same @entity1 fed with a nasogastric (NG) tube and later with a @entity970 tube. METHODS: We enrolled 15 @entity1 who had received NG tube feeding for > 6 months and were about to receive @entity970 tube insertion. We used Ponsky's pull method with 24 Fr feeding tubes. They received two @entity354 scans, one just before @entity970 tube insertion and another 1 week after insertion. We drew regions of interest of radioactivity in the esophagus and stomach manually. The ratios of radioactivity of the region of interest in the esophagus over the stomach ( @entity354 ratio) were calculated to evaluate the severity of @entity354 and compared. RESULTS: The @entity354 ratios of these @entity1 were all small and <3% except one that was 4.7% in one @entity1 before @entity970 tube insertion. There was a small but substantial decrease (65% risk reduction) in @entity354 ratio after @entity970 tube insertion. After arcsine transformation, the difference in the transformed data between @entity1 fed with an NG tube and after @entity970 tube insertion was significant (t= 2.46, p = 0.028), and was lower after @entity970 tube insertion. CONCLUSION: Our study demonstrates by scintigraphy a small but significant reduction of @entity354 after shifting from NG to @entity970 tube feeding.

title: Changes in XXXX in @entity1 with nasogastric tube followed by percutaneous endoscopic gastrostomy.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity354 :: ('MESH:D005764', 'Disease') :: ['gastroesophageal reflux', 'GER']

answer: @entity354 :: (MESH:D005764,Disease) :: ['gastroesophageal reflux']


abstract: In our previous studies, we established a lymphogenous metastatic @entity915 @entity19 model using orthotopic implantation of @entity1 @entity2 cell lines. However, the lymphogenous metastatic potential of each cell line in our models does not reflect that of a @entity5 . In this study, we made orthotopic implanted models using primary cultured cells from surgically-resected @entity2 tissues. Tissues of 5 @entity1 with @entity1149 ( @entity1149 ) were applied to a primary culture method using a collagen gel coated flask. Suspensions of 2.0x10(4) @entity5 cells were injected into the left lung of @entity915 @entity19 . We could maintain primary culture cells from 2 (FM205 and FT821 cells) of 5 @entity2 , and made orthotopically implanted @entity915 @entity19 models. The size of both @entity5 in implanted sites of the lung increased with time. The FM205 cells microscopically were metastasized to the mediastinum by 4 weeks after implantation and macroscopically metastasized by 16 weeks. The FT821 cells were microscopically metastasized to the mediastinum by 4 weeks after implantation and macroscopically metastasized by 6 weeks. The lymphogenous metastatic potential of these primary culture cells was similar to that of clinical @entity5 . As the lymphogenous metastatic potential of this model reflects that of the clinical @entity5 , it is useful for elucidating the mechanism of lymphogenous metastasis and selecting anticancer drugs suitable for an individual @entity1 .

title: Establishment of @entity1 -like @entity915 XXXX model by orthotopically implanting primary cultured cells from surgically-resected @entity2 tissues.

entities_list: @entity1 :: ('9606', 'Species') :: ['human', 'patients']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'cancer', 'primary tumor', 'tumors']

entities_list: @entity2 :: ('MESH:D008175', 'Disease') :: ['lung cancers', 'lung cancer']

entities_list: @entity1149 :: ('MESH:D002289', 'Disease') :: ['NSCLC', 'non-small cell lung cancer']

answer: @entity19 :: (10090,Species) :: ['mouse']


abstract: INTRODUCTION: Bladder augmentation is widely used to treat otherwise unmanageable urinary incontinence. However, it is associated with a large number of complications, of which @entity5 formation is the most severe. @entity3558 proteins and MUC genes are linked, among others, to @entity1494 . OBJECTIVE: To investigate histological alterations as well as changes in expression of @entity2355 and @entity5091 genes and proteins following different types of urinary bladder augmentation or substitution performed in @entity1 and adolescents. @entity1 AND METHODS: Between 1988 and 2013, 91 @entity1 underwent urinary bladder augmentation or substitution at the study institute. @entity1 were included on whom cystoplasty had been performed 4 years previously or earlier, and could have been followed-up prospectively. Thus, 54 @entity1 were involved in the study. In eight @entity1 gastrocystoplasty was performed, in 17 @entity1 ileocystoplasty, and in 22 @entity1 colocystoplasty. Seven @entity1 underwent bladder substitution using a colonic-segment. Biopsies were taken via cystoscopy from the native bladder, from the @entity344 used for augmentation, and from the anastomotic line between these two. One part of the samples was fixed in @entity406 for routine histological processing. The other part of the biopsies was embedded into OCT medium, then cryosectioned and fluorescently double-immunostained for @entity2355 and @entity5091 proteins. Samples from the microscopically @entity75 and from the 15-year-old or older biopsies were processed by laser capture microdissection, and then real-time PCR was done. Data were statistically analyzed by ANOVA and ordinary least squares regression tests. RESULTS: One @entity420 was found in a female @entity1 , 11 years after colocystoplasty. There were no significant changes in the level of @entity2355 and @entity5091 proteins and gene expression in the urothelium and in the @entity344 used for augmentation following ileocystoplasty and gastrocystoplasty. Significant increase in @entity2355 and decrease in @entity5091 protein levels were detected following colocystoplasty in the large bowel segment used for augmentation, both with qualitative and quantitative methods (p  <  0.05) (Figure). The uroepithelium showed no significant change. RT-PCR revealed progressive increase in @entity2355 gene expression and decrease in @entity5091 gene expression after colocystoplasty in the course of time. It also showed highly increased @entity2355 gene expression and decreased @entity5091 gene expression in the samples of @entity1 . CONCLUSIONS: Alterations in gene expression of @entity2355 and @entity5091 might serve as promising markers for early detection of histological changes after colocystoplasty.

title: Long-term histological and @entity3558 alterations in the neobladder mucosa following urinary bladder augmentation or substitution with XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['children', 'Patients', 'patients', 'patient', 'PATIENTS']

entities_list: @entity1494 :: ('MESH:D001745', 'Disease') :: ['malignancies of the urinary bladder and the gastrointestinal system']

entities_list: @entity75 :: ('MESH:D001927', 'Disease') :: ['dysplastic lesions']

entities_list: @entity406 :: ('MESH:D005557', 'Chemical') :: ['formaldehyde']

entities_list: @entity344 :: ('MESH:D005767', 'Disease') :: ['gastrointestinal segment']

entities_list: @entity420 :: ('MESH:D000230', 'Disease') :: ['adenocarcinoma']

answer: @entity344 :: (MESH:D005767,Disease) :: ['gastrointestinal segment']


abstract: BACKGROUND: Many institutions recommend a stepwise approach to intradermal testing for venom @entity566 . This is costly and uncomfortable for the @entity1 . The rationale for this approach is the risk of potential adverse reactions to testing with the maximal dose alone. OBJECTIVE: To evaluate the safety of a single-step approach to venom @entity566 testing. METHODS: The authors retrospectively reviewed the charts of 300 consecutive @entity1 with suspected hymenoptera venom @entity566 based on history who underwent venom @entity566 testing in a single allergist's clinic where a single-step protocol had been adopted. All @entity1 had positive skin test reaction to at least 1 hymenoptera venom. Charts were reviewed for testing protocol used, results of testing, and reported immediate and delayed adverse reactions to testing. RESULTS: All @entity1 underwent testing with an identical single-step protocol with an intradermal dose of 0.02 mL of a 1.0- g/mL concentration of each of the 5 commercially available vespid and @entity5157 venoms. Only 1 @entity1 reported an adverse reaction to testing, which was delayed until the morning after his visit. There were no immediate adverse reactions. The @entity1 who had the delayed reaction was successfully started on venom immunotherapy subsequent to his reaction. CONCLUSION: A single-step venom @entity566 intradermal testing protocol with a 1.0- g/mL concentration of commercially available extracts is a safe option, which, if adopted into practice, could lead to more streamlined care for @entity1 and cost savings for the medical system.

title: XXXX testing: is a graded approach necessary?

answer: @entity566 :: (MESH:D006967,Disease) :: ['Venom allergy']


abstract: OBJECTIVE: To assess the efficacy and tolerability of @entity903 20mg daily, for the treatment of @entity308 and @entity308 associated with @entity148 . METHOD: An open, non-comparative study undertaken at three centers in three cities of Pakistan. A total of 112 in- or out- @entity1 , presenting with a major @entity308 were included in the study. @entity308 was diagnosed according to DSM IV criteria and a Hamilton Rating Scale for @entity308 (HAMD-D) score of >18 on the first 17 items of the HAM-D-21. After a placebo washout period of 7 days, @entity1 were given a 20-mg fixed dose of @entity903 daily in the morning for a period of 6 weeks. After baseline, regular assessments were made at 1, 2, 4 and 6 weeks. Efficacy measures included the HAMD-D, the Clinical Anxiety Scale, The Clinical Global Impression Severity of Illness Scale (CGI-S), and the Clinical Global Impression Improvement Scale (CGI-I). Tolerability was assessed by any adverse event. The primary therapeutic outcome measures were @entity1 who achieved a 50% or greater reduction in HAMD-D score at the end of the treatment or achieved a reduction in final HAMD-D score of < or = 10 points. The final scores of 1 or 2 for CGI-S and CGI-I were considered as full clinical response. RESULTS: Of 112 cases evaluated, 57 were males and 55 females whose ages ranged from 18 to 65 years. There was a clear and statistically significant efficacy of @entity903 on all the major outcome variables. A total of 88% @entity1 achieved a reduction in the final HAMD-D score at the end of treatment. The total HAM-D score reduced to 10 or less in 73% @entity1 at 6 weeks and by this week 76% and 92% @entity1 achieved a score of 1 or 2 for CGI-S and CGI-I, respectively. The mean Clinical Anxiety Scale score reduced from 12.6 at the baseline to 4.4 at the end of treatment. Safety data was evaluated in all 112 @entity1 and @entity903 was well tolerated. Adverse events were experienced by 10% of @entity1 of whom 4% were dropped from the study. @entity390 was the commonest adverse event reported. CONCLUSION: The study shows that @entity903 is an effective, well-tolerated, and safe drug for the treatment of @entity308 .

title: Efficacy and tolerability of @entity903 20 mg daily in the treatment of XXXX and @entity308 associated @entity148 .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients']

entities_list: @entity308 :: ('MESH:D003866', 'Disease') :: ['Depression', 'depression', 'depressive episode']

entities_list: @entity903 :: ('MESH:D017374', 'Chemical') :: ['paroxetine']

answer: @entity308 :: (MESH:D003866,Disease) :: ['depression']


abstract: BACKGROUND: @entity73 is considered a @entity66 in which @entity1 may have delayed @entity356 . The effects of total abdominal colectomy and ileorectal anastomosis on @entity1319 are unknown. The aim of this study was to evaluate @entity356 in @entity1 with @entity73 before and after subtotal colectomy. METHODS: Gastric emptying of a solid meal was studied by scintigraphic technique in 11 @entity1 with @entity73 . The total colonic transit time was more than 72 hours in all @entity1 studied, with delay in transit in all segments of the colon. The @entity356 test was repeated 3 to 6 months after total abdominal colectomy and ileorectal anastomosis in ten of these @entity1 . Before and after surgery, @entity1 filled out a questionnaire to record upper gut symptoms. RESULTS: Solid @entity356 was delayed (T1/2 > upper limit of normal) in 7 of 11 @entity1 with @entity73 . Gastric emptying T1/2 was almost similar before and after surgery. Mean +/- standard deviation was 142 +/- 91 minutes before surgery and 146 +/- 67 minutes after surgery. Symptoms of @entity391 and belching improved significantly after surgery. Symptoms of @entity390 , bloating, and @entity11068 also decreased, but these changes failed to reach statistical significance. CONCLUSION: Despite a reduction in upper gut symptoms, total abdominal colectomy and ileorectal anastomosis does not improve delayed @entity356 in @entity1 with @entity73 .

title: Effect of subtotal colectomy on XXXX of a solid meal in slow-transit constipation.

entities_list: @entity66 :: ('MESH:D004194', 'Disease') :: ['panenteral disease']

entities_list: @entity73 :: ('MESH:D003072', 'Disease') :: ['Idiopathic slow-transit constipation', 'idiopathic slow-transit constipation']

entities_list: @entity391 :: ('MESH:D014839', 'Disease') :: ['vomiting']

entities_list: @entity356 :: ('MESH:D013274', 'Disease') :: ['gastric emptying']

entities_list: @entity1319 :: ('MESH:D015835', 'Disease') :: ['upper gut motility']

answer: @entity356 :: (MESH:D013274,Disease) :: ['gastric emptying']


abstract: @entity189 is the 9(th) most common @entity5 worldwide. Most @entity5 are non-muscle invasive on presentation. However, two-thirds of non-invasive @entity150 will eventually recur with a 25% risk of progression to @entity150 . @entity5 stage, histological grade and pathological invasion of blood vessels and lymphatic tissue are the main indicators for @entity5 prognosis. The gold standard for diagnosing @entity150 is conventional white-light cystoscopy and biopsy. Urine cytology is a highly specific, sensitive test for high-grade @entity5 or @entity2735 ( @entity2735 ). Urinary @entity14276 has an overall sensitivity and specificity for detecting @entity150 of 49% and 87%, respectively. However, there are false-positive results in the presence of @entity293 or @entity811 . The detection of specific gene mutations related to @entity5 has been studied and employed to reproduce markers helpful for diagnosis. According to current studies, molecular markers can be used to predict @entity5 recurrence. From a prognostic point of view, new molecular markers have yet to be established as reliable indicators of @entity146 . We aimed to review the molecular markers with possible prognostic significance that have been discussed in the literature. This review examined the literature for various molecular markers under development for @entity150 in an attempt to optimize @entity1 care and reduce the costs of treating these @entity1 .

title: What are the currently available and in development molecular markers for XXXX ? Will they prove to be useful in the future?

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity2735 :: ('MESH:D002278', 'Disease') :: ['CIS', 'carcinoma in situ']

entities_list: @entity146 :: ('MESH:D001523', 'Disease') :: ['tumor aggressiveness']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'urothelial cancers', 'cancer', 'Tumor', 'urothelial cancer', 'urothelial tumors', 'tumors']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['Urothelial carcinoma']

entities_list: @entity150 :: ('MESH:D001749', 'Disease') :: ['bladder cancers', 'bladder cancer', 'muscle-invasive bladder cancer']

entities_list: @entity811 :: ('MESH:D006417', 'Disease') :: ['hematuria']

entities_list: @entity293 :: ('MESH:D014552', 'Disease') :: ['urinary tract infection']

answer: @entity150 :: (MESH:D001749,Disease) :: ['bladder cancer']


abstract: UNASSIGNED: Intravascular @entity1377 (IPEH) is a benign lesion of the skin and mucosa of vascular origin characterized by reactive proliferation of endothelial cells. A 76-year-old @entity1 was referred presenting a painless nodule on the lip. Intraoral examination revealed bluish submucosal nodular proliferation, measuring 10 * 5 * 5   mm, affecting the lower labial mucosa. The lesion had a firm consistency and it was not fixed to the adjacent tissues. The main differential diagnoses were mucocele/mucus retention cyst, sialolith, or @entity5 . An incisional biopsy was performed and during the intraoperative procedure an encapsulated red-bluish nodular mass was observed. Microscopic analysis revealed papillary endothelial proliferation in the center of the lesion and fibrin admixed with inflammatory cells in organization peripherally. There was no nuclear atypia, mitotic figures, or @entity39 . The endothelial cells were @entity2280 positive, with low Ki-67 proliferation index (4%). @entity1970 highlighted the vessel walls, whereas negativity for D2-40 excluded lymphatic origin. Final diagnosis was IPEH associated with an organizing thrombus. Dentists should be aware about this rare benign vascular lesion, whose final diagnosis is achieved only after histopathology analysis. Surgical removal is the treatment of choice and no recurrence is expected.

title: Oral Intravascular XXXX Associated with an Organizing Thrombus: Case Report and Immunohistochemical Analysis.

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary endothelial hyperplasia']

entities_list: @entity39 :: ('MESH:D009336', 'Disease') :: ['necrosis']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['salivary gland neoplasia']

answer: @entity1377 :: (MESH:D002291,Disease) :: ['Papillary Endothelial Hyperplasia']


abstract: The Semipalatinsk nuclear test site (SNTS), the Republic of Kazakhstan, has been contaminated by radioactive fallout. The alteration of oncogenic molecules in @entity259 around the SNTS was considered worthy of analysis because it presented the potential to elucidate the relationship between radiation exposure and @entity259 . This study aimed to analyze both @entity3546 and @entity4910 expressions in @entity259 around the SNTS. We examined nine cases of @entity10972 , eight cases of @entity652 , and 23 cases of @entity1377 . Immunohistochemically, all @entity189 displayed a strong cytosolic @entity3546 expression, while both @entity10972 and @entity652 showed a significantly lower cytoplasmic @entity3546 (22.2% and 37.5%, respectively). No @entity4910 immunoreactivity was evident in @entity10972 . In contrast, 62.5% of @entity652 and 87.0% of @entity1377 showed @entity4910 overexpression. Additionally, a strong correlation between cytoplasmic @entity3546 and @entity4910 expression was suggested in @entity259 . This study revealed a higher prevalence of both aberrant @entity3546 expression and @entity4910 overexpression in @entity3557 around the SNTS than sporadic cases. The analysis of the alteration of the Wnt signaling-related molecules in @entity259 around the SNTS may be important to gain an insight into radiation-induced thyroid tumorigenesis.

title: Correlation of cytoplasmic @entity3546 and XXXX overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site.

entities_list: @entity3557 :: ('MESH:C536915', 'Disease') :: ['papillary thyroid cancers']

entities_list: @entity1377 :: ('MESH:D002291', 'Disease') :: ['papillary carcinomas', 'papillary carcinoma']

entities_list: @entity10972 :: ('MESH:C535842', 'Disease') :: ['chronic thyroiditis']

entities_list: @entity189 :: ('MESH:D002277', 'Disease') :: ['carcinomas']

entities_list: @entity652 :: ('MESH:D000236', 'Disease') :: ['follicular adenomas']

entities_list: @entity259 :: ('MESH:D013964', 'Disease') :: ['thyroid tumors', 'thyroid cancer', 'thyroid carcinomas']

answer: @entity4910 :: (595,Gene) :: ['cyclin D1']


abstract: OBJECTIVE: To analyze the effect of serum levels of high molecular weight @entity1254 (HMWA) on the occurrence of @entity3036 during subsequent pregnancy in @entity1 with primary pregnancy-induced @entity101 ( @entity5029 ). @entity1 AND METHODS: Thirty @entity1 with primary @entity5029 (observation group) and sixty @entity1 without primary @entity5029 (control group) were consecutively selected. ELISA was used to measure the serum levels of HMWA. The differences in the occurrence of @entity3036 during subsequent pregnancy between the two groups were compared. RESULTS: The serum levels of HMWA in the observation group were significantly lower than in the control group, and they decreased with increased severity of @entity5029 (p < 0.05). In the observation group, the gestational age was lower than that of the control group, and the occurrence of cesarean section and maternal complications were increased. The neonatal weight and Apgar scores were lower than those of the control group, and the occurrence of neonatal complications was increased. The difference was statistically significant (p < 0.05). There were no differences in the time intervals between pregnancies in the two groups. The occurrence of @entity5029 and @entity3036 during subsequent pregnancy in the observation group was significantly higher than that in the control group (p < 0.05). According to receiver operating curve analysis, the sensitivity, specificity, and accuracy of serum HMWA level in predicting the occurrence of @entity3036 during subsequent pregnancy were 85.6%, 74.8%, and 0.824 (95% CI = 0.811-0.936, p = 0.015), respectively. The critical value was 2.4 mg/l. CONCLUSIONS: Decreases of serum levels of HMWA in @entity1 with primary @entity5029 are closely related to the severity of @entity5029 and the outcome of pregnancy, which has important predictive value for the occurrence of @entity3036 during subsequent pregnancy.

title: Effect of serum high molecular weight @entity1254 level on the occurrence of @entity3036 during subsequent pregnancy in @entity1 with primary pregnancy induced XXXX .

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'PATIENTS']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['hypertension']

entities_list: @entity3036 :: ('MESH:D004461', 'Disease') :: ['eclampsia']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: "Blue eye" disease of @entity1707 in Mexico is caused by @entity70216 and characterized by @entity249 in sows and boars, nervous signs in young @entity1707 , and @entity5575 in @entity1707 of all ages. The pathogenesis of reproductive tract lesions in rubulavirus-infected boars has not previously been investigated. In a first experiment, four 9-month-old boars were inoculated with @entity70216 and killed 5, 15, 30 or 45 days post-inoculation (pi). In a second experiment, four similar boars were inoculated with the same virus and two animals were killed on each of days 70 and 80 pi. Swelling of the head of the epididymis developed in all inoculated boars at approximately day 15 pi. @entity1319 and concentration were detected in semen samples collected from one boar from day 21 pi. At post-mortem examination, nodules were seen in the head of the epididymis of the boars killed 15, 30 or 45 days pi and the right testis of the @entity1707 killed 30 days pi was @entity3202 . Corresponding histopathological epididymal alterations included formation of spermatic @entity738 and @entity13312 of ductular epithelium. These lesions were associated with mononuclear cell infiltration and interstitial @entity3385 . Degeneration of seminiferous tubules and interstitial mononuclear cell infiltration were seen in the @entity3202 of the @entity1707 killed 30 days pi. There was @entity82 of the head of the epididymis in all boars killed 70 or 80 days pi and one of these animals also had right testicular @entity194 associated with degeneration of seminiferous tubules, lymphocytic infiltration and giant cell formation. Porcine rubulavirus antigen was detected by immunofluorescence labelling in the head of the epididymis of the @entity1707 killed 15, 30 or 45 days pi and in one animal killed on day 70 pi. These results indicate that @entity70216 can cause severe @entity11570 and reduced semen quality in sexually mature boars.

title: Lesions in the reproductive tract of boars experimentally infected with XXXX .

entities_list: @entity249 :: ('MESH:D007246', 'Disease') :: ['infertility']

entities_list: @entity82 :: ('MESH:D005355', 'Disease') :: ['fibrosis']

entities_list: @entity738 :: ('MESH:D006099', 'Disease') :: ['granulomas']

entities_list: @entity13312 :: ('MESH:C536522', 'Disease') :: ['vacuolar degeneration']

entities_list: @entity5575 :: ('MESH:D003318', 'Disease') :: ['corneal opacity']

entities_list: @entity3202 :: ('MESH:D016109', 'Disease') :: ['atrophic', 'atrophic testis']

entities_list: @entity70216 :: ('53179', 'Species') :: ['porcine rubulavirus']

entities_list: @entity11570 :: ('MESH:D009920', 'Disease') :: ['epididymo-orchitis']

entities_list: @entity3385 :: ('MESH:D012178', 'Disease') :: ['fibroplasia']

entities_list: @entity1319 :: ('MESH:D015835', 'Disease') :: ['Reduced spermatozoan motility']

answer: @entity70216 :: (53179,Species) :: ['porcine rubulavirus']


abstract: @entity1735 ( @entity435 ) ingestion during exercise, in the form of @entity435 -electrolyte beverages, leads to performance benefits during prolonged submaximal and variable intensity exercise. However, the mechanism underlying this ergogenic effect is less clear. Euglycaemia and oxidation of blood @entity413 at high rates late in exercise and a decreased rate of muscle glycogen utilisation (i.e. glycogen 'sparing') have been proposed as possible mechanisms underlying the ergogenic effect of @entity435 ingestion. The prevalence of one or the other mechanism depends on factors such as the type and intensity of exercise, amount, type and timing of @entity435 ingestion, and pre-exercise nutritional and training status of study @entity1 . The type and intensity of exercise and the effect of these on blood @entity413 , plasma @entity2690 and @entity2922 levels, may play a major role in determining the rate of muscle glycogen utilisation when @entity435 is ingested during exercise. The ingestion of @entity435 (except fructose) at a rate of > 45 g/h, accompanied by a significant increase in plasma @entity2690 levels, could lead to decreased muscle glycogen utilisation (particularly in type I fibres) during exercise. Endurance training and alterations in pre-exercise muscle glycogen levels do not seem to affect exogenous @entity413 oxidation during submaximal exercise. Thus, at least during low intensity or intermittent exercise, @entity435 ingestion could result in reduced muscle glycogen utilisation in well trained individuals with high resting muscle glycogen levels. Further research needs to concentrate on factors that regulate @entity413 uptake and energy metabolism in different types of muscle fibres during exercise with and without @entity435 ingestion.

title: @entity1 muscle glycogen metabolism during exercise. Effect of XXXX supplementation.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants']

entities_list: @entity1735 :: ('CHEBI:16646', 'Chemical') :: ['Carbohydrate']

entities_list: @entity2922 :: ('CHEBI:33567', 'Chemical') :: ['catecholamine']

entities_list: @entity413 :: ('MESH:D005947', 'Chemical') :: ['glucose']

answer: @entity1735 :: (CHEBI:16646,Chemical) :: ['carbohydrate']


abstract: OBJECTIVE: The aim of this study was to evaluate the significance of the development of a restrictive response to an acute saline load, defined as an increase in the ratio of peak early to peak late diastolic transmitral flow velocity (E/A ratio) associated with a decrease in the deceleration time, in @entity1 with mild to moderate untreated @entity101 . BACKGROUND: Recognised abnormal patterns of transmitral diastolic flow include, from 'best' to 'worst': prolonged relaxation, pseudonormalisation, and restrictive physiology. The common denominator of these transitions is the constellation of an increase in the E/A ratio associated with a decrease in deceleration time. @entity1 AND METHODS: Sixteen normal control subjects (6 males, 10 females, age 51.6 +/- 6.9 years) and 24 @entity1 with mild to moderate untreated @entity101 (12 males, 12 females, age 46.8 +/- 7.5 years) underwent supine blood pressure measurement with sphygmomanometry, biochemical studies, and transthoracic M-mode, 2D, and Doppler echocardiography before and after an acute saline load (7 mL kg(-1), maximum 500 mL, @entity1219 0.9% within 15 min IV). RESULTS: The baseline E/A ratio was lower (0.90 +/- 0.14 vs. 1.04 +/- 0.18; P < 0.01) and the deceleration time was longer (158.8 +/- 19.4 vs. 135 +/- 8.9 ms; P < 0.01) in @entity1 with @entity101 compared with normotensive controls. However, no @entity1 with @entity101 exhibited a transmitral flow velocity pattern compatible with typical prolonged relaxation. A restrictive response to the acute saline load was observed in 12 (50%) of the @entity101 and none of the control subjects. @entity101 @entity1 with a restrictive response to the acute saline load had a lower baseline E velocity (54.8 +/- 8.7 cm s(-1) vs. 66 +/- 6.4 cm s(-1); P = 0.003), a lower baseline E/A ratio (0.83 +/- 0.13 vs. 0.97 +/- 0.12; P = 0.015), and a longer deceleration time (167.5 +/- 15.4 ms vs. 150 +/- 19.5; P = 0.03) than @entity101 @entity1 without such a response. CONCLUSION: A restrictive response to an acute saline load is indicative of a limited diastolic reserve in @entity1 with mild to moderate untreated @entity101 . Further studies are required in order to evaluate the significance of such a response with regards to risk stratification and efficacy of medical treatment in this @entity1 population.

title: Assessment of the left ventricular diastolic reserve in essential XXXX : the acute saline load test.

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient', 'PATIENTS']

entities_list: @entity101 :: ('MESH:D006973', 'Disease') :: ['Hypertensive', 'hypertension', 'hypertensive']

answer: @entity101 :: (MESH:D006973,Disease) :: ['hypertension']


abstract: OBJECTIVE: To study the clinicopathological features of @entity957 ( @entity957 ) of breast and the diagnosis and treatment of the disease. METHODS: The clinical, operative and pathological data from 7 cases of @entity0 were retrospectively analysed. RESULTS: Five @entity1 complained of painless mass and two of them were accompanied with @entity158 . All @entity1 were diagnosed as having @entity957 by fine-needle aspiration before operation. Two @entity1 underwent modified radical mastectomy, and the others received radical mastectomy. Pathological examination showed @entity957 of the breast with metastasis to axlliary lymph nodes in one @entity1 . Follow-up of four @entity1 revealed that two @entity1 are living well and two @entity1 died. Three @entity1 lost to follow up. CONCLUSION: The diagnosis of @entity957 of the breast is dependent on pathological results. Radical mastectomy including modified radical mastectomy is most effective in the treatment of mammary @entity957 . Postoperative chemotherapy and radiation are necessary auxiliary therapy.

title: [Clinical analysis of XXXX of the breast].

entities_list: @entity1 :: ('9606', 'Species') :: ['patients', 'patient']

entities_list: @entity957 :: ('MESH:D002294', 'Disease') :: ['primary squamous cell carcinoma', 'SCC']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['SCC of breast']

entities_list: @entity158 :: ('MESH:D010146', 'Disease') :: ['local pain']

answer: @entity957 :: (MESH:D002294,Disease) :: ['primary squamous cell carcinoma']


abstract: @entity6835 -like toxin (SLT) has been implicated in the pathogenesis of @entity1381 and its attendant endothelial cell (EC) injury. Key serotypes of @entity526 produce @entity27173 in addition to another highly pro-inflammatory molecule, lipopolysaccharide (LPS). It has previously been established that @entity27173 induces EC apoptosis and that LPS enhances this effect. LPS alone has no affect on @entity1 EC viability, and the mechanism for this enhancement remains unknown. In the present report, we demonstrate that @entity27173 sensitizes EC to LPS-induced apoptosis. Pretreatment with @entity27173 sensitized EC to LPS-induced apoptosis, whereas pretreatment with LPS did not influence @entity27173 -induced apoptosis. @entity27173 exposure resulted in decreased expression of @entity1182 ( @entity1182 ), an anti-apoptotic protein that has previously been shown to block LPS-induced apoptosis. This @entity27173 -mediated decrease in @entity1182 expression preceded the onset of apoptosis elicited by @entity27173 alone or in combination with LPS. @entity27173 -mediated decrements in @entity1182 expression correlated in a dose- and time-dependent manner with sensitization to LPS-induced apoptosis. Finally, transient or stable overexpression of @entity1182 protected against LPS enhancement of @entity27173 -induced apoptosis, and this protection corresponded with sustained expression of @entity1182 . Together, these data suggest that @entity27173 sensitizes EC to LPS-induced apoptosis by inhibiting @entity1182 expression.

title: XXXX -like toxin inhibition of @entity1182 expression sensitizes endothelial cells to bacterial lipopolysaccharide-induced apoptosis.

entities_list: @entity1182 :: ('8837', 'Gene') :: ['FLICE-like inhibitory protein', 'FLIP']

entities_list: @entity1381 :: ('MESH:D006463', 'Disease') :: ['hemolytic uremic syndrome']

entities_list: @entity526 :: ('562', 'Species') :: ['Escherichia coli']

answer: @entity6835 :: (MESH:D004405,Disease) :: ['Shiga']


abstract: OBJECTIVE: The purpose of this study was to assess the prevalence of @entity1817 ( @entity1817 ) @entity3018 in @entity1 with @entity0 and compare breast MRI and PET/CT for detection of @entity1817 @entity3018 . MATERIALS AND METHODS: This retrospective study included 90 @entity1 who underwent MRI and PET/CT before neoadjuvant chemotherapy for clinical stage IIA through IIIA disease. MRI and PET/CT examinations were read independently by two readers trained in breast imaging and nuclear medicine. All @entity1 underwent follow-up MRI at the end of chemotherapy, and 10 with @entity2495 IMNs underwent follow-up PET/CT. Histology was not obtained. @entity1 were considered to have @entity1817 @entity3018 when nodes seen on MRI or having standardized uptake value (SUV) greater than mediastinal blood pool decreased in either size or SUV (or both) after treatment. Features including lymphovascular invasion, @entity5 quadrant(s), and axillary @entity3018 were compared between presence and absence of @entity1817 @entity3018 using Fisher's exact test. Prevalence was determined on the basis of the percentage of @entity1 with @entity1817 @entity3018 by either modality. The McNemar test compared the prevalence of @entity1817 @entity3018 on MRI to its prevalence on PET/CT. RESULTS: Prevalence of @entity1817 @entity3018 was 16% (14/90) by MRI and 14% (13/90) by PET/CT (p = 0.317). After chemotherapy, @entity1817 @entity3018 resolved in 12 of 14 @entity1 (86%). In two @entity1 with poor responses in @entity5 , @entity1817 @entity3018 persisted, and both @entity1 developed @entity3 within 6 months. At 3 years, survival was significantly worse in @entity1 with @entity1817 @entity3018 than in those without (85.7% vs 53.3%, respectively; p = 0.009). CONCLUSION: In @entity1 with @entity0 receiving neoadjuvant chemo-therapy, prevalence of @entity1817 @entity3018 was 16%, equally detected by breast MRI and PET/CT. Identification of @entity1817 @entity3018 may affect treatment and provides prognostic information.

title: Detection of Internal Mammary Adenopathy in XXXX With @entity0 by PET/CT and MRI.

entities_list: @entity1 :: ('9606', 'Species') :: ['women', 'patients', 'Women']

entities_list: @entity3018 :: ('MESH:D009377', 'Disease') :: ['adenopathy']

entities_list: @entity0 :: ('MESH:D001943', 'Disease') :: ['breast cancer', 'advanced breast cancer']

entities_list: @entity5 :: ('MESH:D009369', 'Disease') :: ['tumor', 'primary tumors']

entities_list: @entity1817 :: ('MESH:D012804', 'Disease') :: ['IMN', 'internal mammary node']

entities_list: @entity2495 :: ('MESH:C565498', 'Disease') :: ['hypermetabolic']

entities_list: @entity3 :: ('MESH:D009362', 'Disease') :: ['metastatic disease']

answer: @entity1 :: (9606,Species) :: ['Patients']


abstract: INTRODUCTION: As technological advances allow for the development of more sophisticated measurement of the mechanisms that contribute to compensation for loss of circulating blood volume such as @entity548 , it is important to compare the discriminative ability of these new measures to standard vital signs and other new physiologic metrics of interest. The purpose of this study was to compare the discriminative ability of the following three measures to predict the onset of hemodynamic decompensation: peripheral perfusion index (PPI), pulse pressure variability ( @entity2286 ), and the compensatory reserve index (CRI). MATERIALS AND METHODS: There were 51 healthy @entity1 who underwent a progressive simulated @entity548 to induce central @entity3485 by lower body negative pressure (LBNP). The least-squares means and 95% confidence intervals for each measure were reported by LBNP level and stratified by tolerance status (high tolerance vs. low tolerance). Generalized estimating equations were used to perform repeated measures logistic regression analysis by regressing the onset of hemodynamic decompensation on each of the vital signs of interest. These probabilities were used to calculate sensitivity, specificity, and receiver-operating characteristic area under the curve (ROCAUC) for PPI, @entity2286 , and CRI. RESULTS: Compared with both @entity2286 (ROCAUC=0.79) and PPI (0.56), the CRI (0.90) had superior discriminative ability (P <=0.0001) to predict the onset of hemodynamic decompensation. This included higher sensitivity (0.86 vs. 0.78 and 0.71) and specificity (0.78 vs. 0.69 and 0.29) for the CRI compared with @entity2286 and PPI, respectively. Further, CRI was the only measure with mean predicted probabilities of the onset of hemodynamic decompensation that progressively increased as the level of simulated @entity548 increased. DISCUSSION: There are two potential rationales for why the CRI had superior discriminative ability to predict hemodynamic decompensation. First, the CRI more accurately predicted the onset of hemodynamic decompensation at all levels of simulated @entity548 , but especially at lower levels of @entity548 . Second, the CRI was better able to differentiate high versus low tolerant @entity1 . CONCLUSION: Consistent with previous research, the CRI had superior discriminative ability to predict the onset of hemodynamic decompensation. For those @entity1 at greatest risk for developing impending @entity1457 , identifying the most sensitive and specific measures of the onset of hemodynamic decompensation is critical for both the early recognition and implementation of life-saving interventions.

title: Predictors of the Onset of Hemodynamic Decompensation XXXX : Comparison of the Peripheral Perfusion Index, Pulse Pressure Variability, and Compensatory Reserve Index.

entities_list: @entity1 :: ('9606', 'Species') :: ['participants', 'patients']

entities_list: @entity548 :: ('MESH:D006470', 'Disease') :: ['hemorrhage']

entities_list: @entity1457 :: ('MESH:D012769', 'Disease') :: ['circulatory shock']

entities_list: @entity3485 :: ('MESH:D020896', 'Disease') :: ['hypovolemia']

answer: @entity3485 :: (MESH:D020896,Disease) :: ['During Progressive Central Hypovolemia']


abstract: One of the hallmark events regulating the process of osteogenesis is the transition of undifferentiated @entity1 mesenchymal stem cells (hMSCs) found in the bone marrow into mineralized-matrix producing osteoblasts (hOSTs) through mechanisms that are not entirely understood. With recent developments in mass spectrometry and its potential application to the systematic definition of the stem cell proteome, proteins that govern cell fate decisions can be identified and tracked during this differentiation process. We hypothesize that protein profiling of hMSCs and hOSTs will identify potential osteogenic marker proteins associated with hMSC commitment and hOST differentiation. To identify markers for each cell population, we analyzed the expression of hMSC proteins and compared them to that of hOST by two-dimensional gel electrophoresis and two-dimensional liquid chromatography tandem mass spectrometry (2D LC- @entity15 / @entity15 ). The 2D LC- @entity15 / @entity15 data sets were analyzed using the Database for Annotation, Visualization and Integrated Discovery (DAVID). Only 34% of the spots in 2D gels were found in both cell populations; of those that differed between populations, 65% were unique to hOST cells. Of the 755 different proteins identified by 2D LCMS/ @entity15 in both cell populations, two sets of 247 and 158 proteins were found only in hMSCs and hOST cells, respectively. Differential expression of some of the identified proteins was further confirmed by Western blot analyses. Substantial differences in clusters of proteins responsible for @entity460 - based signaling and cell adhesion were found between the two cell types. Osteogenic differentiation is accompanied by a substantial change in the overall protein expression profile of hMSCs. This study, using gene ontology analysis, reveals that these changes occur in clusters of functionally related proteins. These proteins may serve as markers for identifying stem cell differentiation into osteogenic fates because they promote differentiation by mechanisms that remain to be defined.

title: Comparing the protein expression profiles of @entity1 mesenchymal stem cells and XXXX osteoblasts using gene ontologies.

entities_list: @entity460 :: ('MESH:D002118', 'Chemical') :: ['calcium']

answer: @entity1 :: (9606,Species) :: ['human']


abstract: Fusarium head blight (FHB) caused by the filamentous fungus @entity12069 is one of the most severe diseases threatening the production of small grains. Infected grains are often contaminated with mycotoxins such as @entity12071 and trichothecences. During survey of contamination by FHB in @entity579 grains, we found a bacterial isolate, designated as BN1, antagonistic to @entity12069 . The strain BN1 had branching vegetative hyphae and spores, and its aerial hyphae often had long, straight filaments bearing spores. The 16S rRNA gene of BN1 had 100% sequence identity with those found in several Streptomyces species. Phylogenetic analysis of ITS regions showed that BN1 grouped with S. sampsonii with 77% bootstrap value, suggesting that BN1 was not a known Streptomyces species. In addition, the efficacy of the BN1 strain against @entity12069 strains was tested both in vitro and in vivo. @entity3505 seedling length was significantly decreased by @entity12069 infection. However, this effect was mitigated when @entity3505 seeds were treated with BN1 spore suspension prior to @entity12069 infection. BN1 also significantly decreased FHB severity when it was sprayed onto @entity3505 heads, whereas BN1 was not effective when @entity3505 heads were point inoculated. These results suggest that spraying of BN1 spores onto @entity3505 heads during the @entity3505 flowering season can be efficient for plant protection. Mechanistic studies on the antagonistic effect of BN1 against @entity12069 remain to be analyzed.

title: Biological Efficacy of Streptomyces sp. Strain BN1 against the Cereal Head Blight Pathogen XXXX .

entities_list: @entity12069 :: ('5518', 'Species') :: ['Fusarium graminearum', 'F. graminearum']

entities_list: @entity12071 :: ('MESH:D015025', 'Chemical') :: ['zearalenone']

answer: @entity12069 :: (5518,Species) :: ['Fusarium graminearum']