query: Longitudinal analysis of discussion topics in an online breast cancer community using convolutional neural networks

positive: NLTK: The Natural Language Toolkit NLTK, the Natural Language Toolkit, is a suite of open source program modules, tutorials and problem sets, providing ready-to-use computational linguistics courseware. NLTK covers symbolic and statistical natural language processing, and is interfaced to annotated corpora. Students augment and replace existing components, learn structured programming by example, and manipulate sophisticated models from the outset.

positive: Convolutional Neural Networks for Sentence Classification We report on a series of experiments with convolutional neural networks (CNN) trained on top of pre-trained word vectors for sentence-level classification tasks. We show that a simple CNN with little hyperparameter tuning and static vectors achieves excellent results on multiple benchmarks. Learning task-specific vectors through fine-tuning offers further gains in performance. We additionally propose a simple modification to the architecture to allow for the use of both task-specific and static vectors. The CNN models discussed herein improve upon the state of the art on 4 out of 7 tasks, which include sentiment analysis and question classification.

positive: Parameter estimation for text analysis Presents parameter estimation methods common with discrete probability distributions, which is of particular interest in text modeling. Starting with maximum likelihood, a posteriori and Bayesian estimation, central concepts like conjugate distributions and Bayesian networks are reviewed. As an application, the model of latent Dirichlet allocation (LDA) is explained in detail with a full derivation of an approximate inference algorithm based on Gibbs sampling, including a discussion of Dirichlet hyperparameter estimation. History: version 1: May 2005, version 2.4: August 2008.

positive: A COEFFICIENT OF AGREEMENT FOR NOMINAL SCALES 1

positive: Least Squares Support Vector Machine Classifiers In this letter we discuss a least squares version for support vector machine (SVM) classifiers. Due to equality type constraints in the formulation, the solution follows from solving a set of linear equations, instead of quadratic programming for classical SVM's. The approach is illustrated on a two-spiral benchmark classification problem.

negative: Vehicle Routing with Drones We introduce a package service model where trucks as well as drones can deliver packages. Drones can travel on trucks or fly; but while flying, drones can only carry one package at a time and have to return to a truck to charge after each delivery. We present a heuristic algorithm to solve the problem of finding a good schedule for all drones and trucks. The algorithm is based on two nested local searches, thus the definition of suitable neighbourhoods of solutions is crucial for the algorithm. Empirical tests show that our algorithm performs significantly better than a natural Greedy algorithm. Moreover, the savings compared to solutions without drones turn out to be substantial, suggesting that delivery systems might considerably benefit from using drones in addition to trucks.

negative: 2 REINVENTING GROUNDED THEORY : SOME QUESTIONS ABOUT THEORY , GROUND AND DISCOVERY Grounded theory‖s popularity persists after three decades of broad-ranging critique. We discuss here three problematic notions – “theory,” “ground” and “discovery” – which linger in the continuing use and development of grounded theory procedures. We argue that far from providing the epistemic security promised by grounded theory, these notions – embodied in continuing reinventions of grounded theory – constrain and distort qualitative inquiry. We argue that what is contrived is not in fact theory in any meaningful sense, that “ground” is a misnomer when talking about interpretation and that what ultimately materializes following grounded theory procedures is less like discovery and more akin to invention. The procedures admittedly provide signposts for qualitative inquirers, but educational researchers should be wary, for the significance of interpretation, narrative and reflection can be undermined in the procedures of grounded theory.

negative: Ways of Asking and Replying in Duplicate Question Detection This paper presents the results of systematic experimentation on the impact in duplicate question detection of different types of questions across both a number of established approaches and a novel, superior one used to address this language processing task. This study permits to gain a novel insight on the different levels of robustness of the diverse detection methods with respect to different conditions of their application, including the ones that approximate real usage scenarios.

negative: Exploitation of Dual-Polarization Diversity for 5G Millimeter-Wave MIMO Beamforming Systems For the first time, to the best of our knowledge, this paper reports a complete millimeter wave (mmWave) wireless system, which coherently utilizes polarization diversity, multi-input multioutput (MIMO), and beamforming technologies applicable for upcoming fifth generation wireless mobile terminals. Using an interdisciplinary approach across the entire layers constituting of antennas, RF architecture, and digital modem, the polarization of the presented mmWave beamforming antenna system dynamically adapts to the channel environments and MIMO transmission modes. Empirical investigations, which are taken under real-life environments, ascertain that implementing switchable dual-polarized array antennas can alleviate the complexity of the beam searching procedure and MIMO channelization. In addition, experimental results acquired from intensive system level tests indicate more than 22 dB averaged cross-polarization discrimination under polarized MIMO channel conditions at the 60 GHz band. The beam selection algorithm that can be easily implemented based on power metric is confirmed to feature a 99.5% accuracy in comparison with the optimal selection algorithm derived from the theoretical maximal capacity.

negative: The Overview of Research on Microgrid Protection Development In general, the microgrid can operate in both grid-connection mode and islanded mode that challenges the traditional over-current protection scheme in the distribution network. The novel research and development of protection, including both the microgrid and distribution network are comprehensively analyzed in this paper, which mainly focuses on two aspects. The first one analyses the impact on the network protection from the fault current feature while microgrid-connected. Secondly, several innovative protection schemes for network and microgrid are discussed. It is essential to improve traditional protection schemes by using communication techniques. In order to protect the microgrid in islanded mode, two innovative voltage protection schemes are discussed. However, the differential current protection scheme is possibly still the most effective solution for both network and microgrid.

negative: An improved anomaly detection and diagnosis framework for mobile network operators The ever increasing complexity of commercial mobile networks drives the need for methods capable of reducing human workload required for network troubleshooting. In order to address this issue, several attempts have been made to develop automatic anomaly detection and diagnosis frameworks for mobile network operators. In this paper, the latest improvements introduced to one of those frameworks are discussed, including more sophisticated profiling and detection capabilities. The new algorithms further reduce the need for human intervention related to the proper configuration of the profiling and anomaly detection apparatus. The main concepts of the new approach are described and illustrated with an explanatory showcase featuring performance data from a live 3 G network.

negative: DFuzzy: a deep learning-based fuzzy clustering model for large graphs Graph clustering is successfully applied in various applications for finding similar patterns. Recently, deep learning- based autoencoder has been used efficiently for detecting disjoint clusters. However, in real-world graphs, vertices may belong to multiple clusters. Thus, it is obligatory to analyze the membership of vertices toward clusters. Furthermore, existing approaches are centralized and are inefficient in handling large graphs. In this paper, a deep learning-based model ‘DFuzzy’ is proposed for finding fuzzy clusters from large graphs in distributed environment. It performs clustering in three phases. In first phase, pre-training is performed by initializing the candidate cluster centers. Then, fine tuning is performed to learn the latent representations by mining the local information and capturing the structure using PageRank. Further, modularity is used to redefine clusters. In last phase, reconstruction error is minimized and final cluster centers are updated. Experiments are performed over real-life graph data, and the performance of DFuzzy is compared with four state-of-the-art clustering algorithms. Results show that DFuzzy scales up linearly to handle large graphs and produces better quality of clusters when compared to state-of-the-art clustering algorithms. It is also observed that deep structures can help in getting better graph representations and provide improved clustering performance.

negative: A recommender system based on historical usage data for web service discovery The tremendous growth in the amount of available web services impulses many researchers on proposing recommender systems to help users discover services. Most of the proposed solutions analyzed query strings and web service descriptions to generate recommendations. However, these text-based recommendation approaches depend mainly on user’s perspective, languages, and notations, which easily decrease recommendation’s efficiency. In this paper, we present an approach in which we take into account historical usage data instead of the text-based analysis. We apply collaborative filtering technique on user’s interactions. We propose and implement four algorithms to validate our approach. We also provide evaluation methods based on the precision and recall in order to assert the efficiency of our algorithms.

negative: Detection of leukemia in human blood sample based on microscopic images: A study At the moment, identification of blood disorders is through visual inspection of microscopic images of blood cells. From the identification of blood disor de s, it can lead to classification of certain dise ases related to blood. This paper describes a preliminar y study of developing a detection of leukemia types using microscopic blood sample images. Analyzing through images is very important as from images, diseases can be detected and diagnosed at earlier stage. Fro m there, further actions like controlling, monitori ng and prevention of diseases can be done. Images are used as they are cheap and do not require expensive tes ting and lab equipments. The system will focus on white blood cells disease, leukemia. The system will use features in microscopic images and examine changes on texture, geometry, color and statistical analysi s. Changes in these features will be used as a classif ier input. A literature review has been done and Reinforcement Learning is proposed to classify type s of leukemia. A little discussion about issues inv olved by researchers also has been prepared.

negative: A Surgical Palpation Probe With 6-Axis Force/Torque Sensing Capability for Minimally Invasive Surgery A novel surgical palpation probe installing a miniature 6-axis force/torque (F/T) sensor is presented for robot-assisted minimally invasive surgery. The 6-axis F/T sensor is developed by using the capacitive transduction principle and a novel capacitance sensing method. The sensor consists of only three parts, namely a sensing printed circuit board, a deformable part, and a base part. The simple configuration leads to simpler manufacturing and assembly processes in conjunction with high durability and low weight. In this study, a surgical instrument installed with a surgical palpation probe is implemented. The 6-axis F/T sensing capability of the probe has been experimentally validated by comparing it with a reference 6-axis F/T sensor. Finally, a vivo tissue palpation task is performed in a simulated surgical environment with an animal organ and a relatively hard simulated cancer buried under the surface of the organ.

negative: A review of essential standards and patent landscapes for the Internet of Things: A key enabler for Industry 4.0 This paper is a formal overview of standards and patents for Internet of Things (IoT) as a key enabler for the next generation advanced manufacturing, referred as Industry 4.0 (I 4.0). IoT at the fundamental level is a means of connecting physical objects to the Internet as a ubiquitous network that enables objects to collect and exchange information. The manufacturing industry is seeking versatile manufacturing service provisions to overcome shortened product life cycles, increased labor costs, and fluctuating customer needs for competitive marketplaces. This paper depicts a systematic approach to review IoT technology standards and patents. The thorough analysis and overview include the essential standard landscape and the patent landscape based on the governing standards organizations for America, Europe and China where most global manufacturing bases are located. The literature of emerging IoT standards from the International Organization for Standardization (ISO), the International Electrotechnical Commission (IEC) and the Guobiao standards (GB), and global patents issued in US, Europe, China and World Intellectual Property Organization (WIPO) are systematically presented in this study. 2016 Elsevier Ltd. All rights reserved.

negative: TanDEM-X: A Satellite Formation for High-Resolution SAR Interferometry TanDEM-X (TerraSAR-X add-on for digital elevation measurements) is an innovative spaceborne radar interferometer that is based on two TerraSAR-X radar satellites flying in close formation. The primary objective of the TanDEM-X mission is the generation of a consistent global digital elevation model (DEM) with an unprecedented accuracy, which is equaling or surpassing the HRTI-3 specification. Beyond that, TanDEM-X provides a highly reconfigurable platform for the demonstration of new radar imaging techniques and applications. This paper gives a detailed overview of the TanDEM-X mission concept which is based on the systematic combination of several innovative technologies. The key elements are the bistatic data acquisition employing an innovative phase synchronization link, a novel satellite formation flying concept allowing for the collection of bistatic data with short along-track baselines, as well as the use of new interferometric modes for system verification and DEM calibration. The interferometric performance is analyzed in detail, taking into account the peculiarities of the bistatic operation. Based on this analysis, an optimized DEM data acquisition plan is derived which employs the combination of multiple data takes with different baselines. Finally, a collection of instructive examples illustrates the capabilities of TanDEM-X for the development and demonstration of new remote sensing applications.

negative: Human-Computer Interaction for Complex Pattern Recognition Problems We review some applications of human-computer interaction that alleviate the complexity of visual recognition by partitioning it into human and machine tasks to exploit the differences between human and machine capabilities. Human involvement offers advantages, both in the design of automated pattern classification systems, and at the operational level of some image retrieval and classification tasks. Recent development of interactive systems has benefited from the convergence of computer vision and psychophysics in formulating visual tasks as computational processes. Computer-aided classifier design and exploratory data analysis are already well established in pattern recognition and machine learning, but interfaces and functionality are improving. On the operational side, earlier recognition systems made use of human talent only in preprocessing and in coping with rejects. Most current content-based image retrieval systems make use of relevance feedback without direct image interaction. In contrast, some visual object classification systems can exploit such interaction. They require, however, a domain-specific visible model that makes sense to both human and computer.

negative: Toward an integrated knowledge discovery and data mining process model Enterprise decision making is continuously transforming in the wake of ever increasing amounts of data. Organizations are collecting massive amounts of data in their quest for knowledge nuggets in form of novel, interesting, understandable patterns that underlie these data. The search for knowledge is a multi-step process comprising of various phases including development of domain (business) understanding, data understanding, data preparation, modeling, evaluation and ultimately, the deployment of the discovered knowledge. These phases are represented in form of Knowledge Discovery and Data Mining (KDDM) Process Models that are meant to provide explicit support towards execution of the complex and iterative knowledge discovery process. Review of existing KDDM process models reveals that they have certain limitations (fragmented design, only a checklist-type description of tasks, lack of support towards execution of tasks, especially those of the business understanding phase etc) which are likely to affect the efficiency and effectiveness with which KDDM projects are currently carried out. This dissertation addresses the various identified limitations of existing KDDM process models through an improved model (named the Integrated Knowledge Discovery and Data Mining Process Model) which presents an integrated view of the KDDM process and provides explicit support towards execution of each one of the tasks outlined in the model. We also evaluate the effectiveness and efficiency offered by the IKDDM model against CRISP-DM, a leading KDDM process model, in aiding data mining users to execute various tasks of the KDDM process. Results of statistical tests

negative: CryptoDL : Towards Deep Learning over Encrypted Data With increasing growth of cloud services, machine learning services can be run on cloud providers’ infrastructure where training and deploying machine learning models are performed on cloud servers. However, machine learning solutions require access to the raw data, which can create potential security and privacy risks. In this work, we take the first steps towards developing theoretical foundation for implementing deep learning algorithms in encrypted domain and propose a method to adopt deep neural networks (NN) within the practical limitations of current homomorphic encryption schemes. We first design two methods for approximation of activation functions with low degree polynomials. Then, we train NNs with the generated polynomials and analyze the performance of the trained models. Finally, we run the low degree polynomials over encrypted values to estimate the computation costs and time.

negative: Exploiting Topic based Twitter Sentiment for Stock Prediction *This work is supported by a grant from National Science Foundation (IIS-1111092) and a strategic research grant from City University of Hong Kong (7002770) *The work was done when the first author was visiting University of Illinois at Chicago. Abstract • The Web has seen a tremendous rise in social media. • People’s experiences and opinions expressed in Social Media (e.g., Twitter, Facebook) contain rich social signals (e.g., about consumer sentiment, stock market, economic conditions, etc.). • The goal of this paper is to exploit public sentiment for stock market prediction. • Topic based sentiment is an important factor in stock prediction because it reflects public opinions about current issues/topics. • We employ a Bayesian non-parametric topic-based sentiment time series approach learned from streaming tweets to predict the S&P100 Stock Index.

negative: Intelligent Maze Solving Robot Based on Image Processing and Graph Theory Algorithms The most important task for maze solving robots is the fast and reliable finding of its shortest path from its initial point to its final destination point. This paper proposes an intelligent maze solving robot that can determine its shortest path on a line maze based on image processing and artificial intelligence algorithms. The image of the line maze is captured by a camera and sent to the computer to be analyzed and processed by a program developed using Visual C++ and OpenCV libraries and based on graph theory algorithms. The developed program solves the captured maze by examining all possible paths exist in the maze that could convey the robot to the required destination point. After that, the best shortest path is determined and then the instructions that guide the car-like robot to reach its desired destination point are sent to the robot through Bluetooth. The robot follows the received guide path to reach its destination. The proposed approach works faster than the traditional methods which push the robot to move through the maze cell by cell in order to find its destination point. Moreover, the proposed method allows the maze solving robot to avoid trapping and falling in infinity loops. Applications of maze solving systems include intelligent traffic control that helps ambulances, fire fighters, or rescuing robots to find their shortest path to their destination.

negative: Monte-Carlo Tree Search for the Game of "7 Wonders" Monte-Carlo Tree Search algorithm, and in particular with the Upper Confidence Bounds formula, provided huge improvements for AI in numerous games, particularly in Go, Hex, Havannah, Amazons and Breakthrough. In this work we study this algorithm on a more complex game, the game of “7 Wonders”. This card game gathers together several known difficult features, such as hidden information, N-player and stochasticity. It also includes an inter-player trading system that induces a combinatorial search to decide which decisions are legal. Moreover it is difficult to hand-craft an efficient evaluation function since the card values are heavily dependent upon the stage of the game and upon the other player decisions. We show that, in spite of the fact that “7 Wonders” is apparently not so related to abstract games, a lot of known results still hold.

negative: Collaboration, creativity and the co-construction of oral and written texts The Open University's repository of research publications and other research outputs Collaboration, creativity and the co-construction of oral and written texts Journal Article Copyright and Moral Rights for the articles on this site are retained by the individual authors and/or other copyright owners. For more information on Open Research Online's data policy on reuse of materials please consult the policies page. (To be included in a special issue of Thinking Skills and Creativity, on " Collaborative Abstract In this paper we explore how primary school children 'learn to collaborate' and 'collaborate to learn' on creative writing projects by using diverse cultural artefacts-including oracy, literacy and ICT. We begin by reviewing some key socio-cultural concepts which serve as a theoretical framework for the research reported. Secondly, we describe the context in which the children talked and worked together to create their projects. This context is a 'learning community' developed as part of an innovative educational programme with the aim of promoting the social construction of knowledge among all participants. We then present microgenetic analyses of the quality of the interaction and dialogues taking place as peers worked together on their projects, and how these collaborative processes and uses of the mediational artefacts were taken up by the children. In order to exemplify these processes, our analyses centre on a selection of examples of dialogues, texts and multimedia products of stories created by groups of 4th grade (9-10 year-old) children. Overall, the work reveals the dynamic functioning in educational settings of some central socio-cultural concepts. These include: co-construction; intertextuality and intercontextuality amongst oracy, literacy and uses of ICT; collaborative creativity; development of dialogical and text production strategies and appropriation of diverse cultural artefacts for knowledge construction.

negative: Automated segmentation of 3D anatomical structures on CT images by using a deep convolutional network based on end-to-end learning approach We have proposed an end-to-end learning approach that trained a deep convolutional neural network (CNN) for automatic CT image segmentation, which accomplished a voxel-wised multiple classification to directly map each voxel on 3D CT images to an anatomical label automatically. The novelties of our proposed method were (1) transforming the anatomical structures segmentation on 3D CT images into a majority voting of the results of 2D semantic image segmentation on a number of 2D-slices from different image orientations, and (2) using “convolution” and “deconvolution” networks to achieve the conventional “coarse recognition” and “fine extraction” functions which were integrated into a compact all-in-one deep CNN for CT image segmentation. The advantage comparing to previous works was its capability to accomplish real-time image segmentations on 2D slices of arbitrary CT-scan-range (e.g. body, chest, abdomen) and produced correspondingly-sized output. In this paper, we propose an improvement of our proposed approach by adding an organ localization module to limit CT image range for training and testing deep CNNs. A database consisting of 240 3D CT scans and a human annotated ground truth was used for training (228 cases) and testing (the remaining 12 cases). We applied the improved method to segment pancreas and left kidney regions, respectively. The preliminary results showed that the accuracies of the segmentation results were improved significantly (pancreas was 34% and kidney was 8% increased in Jaccard index from our previous results). The effectiveness and usefulness of proposed improvement for CT image segmentations were confirmed.

negative: A comparative analysis of common YouTube comment spam filtering techniques Ever since its development in 2005, YouTube has been providing a vital social media platform for video sharing. Unfortunately, YouTube users may have malicious intentions, such as disseminating malware and profanity. One way to do so is using the comment field for this purpose. Although YouTube provides a built-in tool for spam control, yet it is insufficient for combating malicious and spam contents within the comments. In this paper, a comparative study of the common filtering techniques used for YouTube comment spam is conducted. The study deploys datasets extracted from YouTube using its Data API. According to the obtained results, high filtering accuracy (more than 98%) can be achieved with low-complexity algorithms, implying the possibility of developing a suitable browser extension to alleviate comment spam on YouTube in future.

negative: A Novel Method for Comparative Analysis of DNA Sequences by Ramanujan-Fourier Transform Alignment-free sequence analysis approaches provide important alternatives over multiple sequence alignment (MSA) in biological sequence analysis because alignment-free approaches have low computation complexity and are not dependent on high level of sequence identity. However, most of the existing alignment-free methods do not employ true full information content of sequences and thus can not accurately reveal similarities and differences among DNA sequences. We present a novel alignment-free computational method for sequence analysis based on Ramanujan-Fourier transform (RFT), in which complete information of DNA sequences is retained. We represent DNA sequences as four binary indicator sequences and apply RFT on the indicator sequences to convert them into frequency domain. The Euclidean distance of the complete RFT coefficients of DNA sequences are used as similarity measures. To address the different lengths of RFT coefficients in Euclidean space, we pad zeros to short DNA binary sequences so that the binary sequences equal the longest length in the comparison sequence data. Thus, the DNA sequences are compared in the same dimensional frequency space without information loss. We demonstrate the usefulness of the proposed method by presenting experimental results on hierarchical clustering of genes and genomes. The proposed method opens a new channel to biological sequence analysis, classification, and structural module identification.

negative: Safe Exploration of State and Action Spaces in Reinforcement Learning In this paper, we consider the important problem of safe exploration in reinforcement learning. While reinforcement learning is well-suited to domains with complex transition dynamics and high-dimensional state-action spaces, an additional challenge is posed by the need for safe and efficient exploration. Traditional exploration techniques are not particularly useful for solving dangerous tasks, where the trial and error process may lead to the selection of actions whose execution in some states may result in damage to the learning system (or any other system). Consequently, when an agent begins an interaction with a dangerous and high-dimensional state-action space, an important question arises; namely, that of how to avoid (or at least minimize) damage caused by the exploration of the state-action space. We introduce the PI-SRL algorithm which safely improves suboptimal albeit robust behaviors for continuous state and action control tasks and which efficiently learns from the experience gained from the environment. We evaluate the proposed method in four complex tasks: automatic car parking, pole-balancing, helicopter hovering, and business management.

negative: Optical see-through head up displays' effect on depth judgments of real world objects Recent research indicates that users consistently underestimate depth judgments to Augmented Reality (AR) graphics when viewed through optical see-through displays. However, to our knowledge, little work has examined how AR graphics may affect depth judgments of real world objects that have been overlaid or annotated with AR graphics. This study begins a preliminary analysis whether AR graphics have directional effects on users' depth perception of real-world objects, as might be experienced in vehicle driving scenarios (e.g., as viewed via an optical see-through head-up display or HUD). Twenty-four participants were asked to judge the depth of a physical pedestrian proxy figure moving towards them at a constant rate of 1 meter/second. Participants were shown an initial target location that varied in distance from 11 to 20 m and were then asked to press a button to indicate when the moving target was perceived to be at the previously specified target location. Each participant experienced three different display conditions: no AR visual display (control), a conformal AR graphic overlaid on the pedestrian via a HUD, and the same graphic presented on a tablet physically located on the pedestrian. Participants completed 10 trials (one for each target distance between 11 and 20 inclusive) per display condition for a total of 30 trials per participant. The judged distance from the correct location was recorded, and after each trial, participants' confidence in determining the correct distance was captured. Across all conditions, participants underestimated the distance of the physical object consistent with existing literature. Greater variability was observed in the accuracy of distance judgments under the AR HUD condition relative to the other two display conditions. In addition, participant confidence levels were considerably lower in the AR HUD condition.

negative: Stochastic Activation Pruning for Robust Adversarial Defense Neural networks have been found vulnerable to adversarial examples. Carefully chosen perturbations to real images, while imperceptible to humans, induce misclassification and threaten the reliability of deep learning systems in the wild. To guard against adversarial examples, we take inspiration from game theory. We cast the problem as a minimax zero-sum game between the adversary and the model. For such games, it is in general optimal for players to use a stochastic policy, also known as a mixed strategy. In light of this, we propose a mixed strategy for the model: stochastic activation pruning. SAP prunes a random subset of activations (preferentially pruning activations with smaller magnitude) and scales up the survivors to compensate. SAP can be applied to pre-trained neural networks—even adversarially trained models—without fine-tuning, providing robustness against adversarial examples. Experiments demonstrate that SAP confers robustness in the adversarial setting, increasing accuracy whilst preserving calibration.

negative:
Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007 BACKGROUND
Quality of life in patients with breast cancer is an important outcome. This paper presents an extensive overview on the topic ranging from descriptive findings to clinical trials.

METHODS
This was a bibliographic review of the literature covering all full publications that appeared in English language biomedical journals between 1974 and 2007. The search strategy included a combination of key words 'quality of life' and 'breast cancer' or 'breast carcinoma' in titles. A total of 971 citations were identified and after exclusion of duplicates, the abstracts of 606 citations were reviewed. Of these, meetings abstracts, editorials, brief commentaries, letters, errata and dissertation abstracts and papers that appeared online and were indexed ahead of publication were also excluded. The remaining 477 papers were examined. The major findings are summarized and presented under several headings: instruments used, validation studies, measurement issues, surgical treatment, systemic therapies, quality of life as predictor of survival, psychological distress, supportive care, symptoms and sexual functioning.

RESULTS
Instruments-Several valid instruments were used to measure quality of life in breast cancer patients. The European Organization for Research and Treatment of Cancer Core Cancer Quality of Life Questionnaire (EORTC QLQ-C30) and its breast cancer specific complementary measure (EORTC QLQ-BR23) and the Functional Assessment Chronic Illness Therapy General questionnaire (FACIT-G) and its breast cancer module (FACIT-B) were found to be the most common and well developed instruments to measure quality of life in breast cancer patients. Surgery-different surgical procedures led to relatively similar results in terms of quality of life assessments, although mastectomy patients compared to conserving surgery patients usually reported a lower body image and sexual functioning. Systemic therapies-almost all studies indicated that breast cancer patients receiving chemotherapy might experience several side-effects and symptoms that negatively affect their quality of life. Adjuvant hormonal therapies also were found to have similar negative impact on quality of life, although in general they were associated with improved survival. Quality of life as predictor of survival-similar to known medical factors, quality of life data in metastatic breast cancer patients was found to be prognostic and predictive of survival time. Psychological distress-anxiety and depression were found to be common among breast cancer patients even years after the disease diagnosis and treatment. Psychological factors also were found to predict subsequent quality of life or even overall survival in breast cancer patients. Supportive care-clinical treatments to control emesis, or interventions such as counseling, providing social support and exercise could improve quality of life. Symptoms-Pain, fatigue, arm morbidity and postmenopausal symptoms were among the most common symptoms reported by breast cancer patients. As recommended, recognition and management of these symptoms is an important issue since such symptoms impair health-related quality of life. Sexual functioning-breast cancer patients especially younger patients suffer from poor sexual functioning that negatively affect quality of life.

CONCLUSION
There was quite an extensive body of the literature on quality of life in breast cancer patients. These papers have made a considerable contribution to improving breast cancer care, although their exact benefit was hard to define. However, quality of life data provided scientific evidence for clinical decision-making and conveyed helpful information concerning breast cancer patients' experiences during the course of the disease diagnosis, treatment, disease-free survival time, and recurrences; otherwise finding patient-centered solutions for evidence-based selection of optimal treatments, psychosocial interventions, patient-physician communications, allocation of resources, and indicating research priorities were impossible. It seems that more qualitative research is needed for a better understanding of the topic. In addition, issues related to the disease, its treatment side effects and symptoms, and sexual functioning should receive more attention when studying quality of life in breast cancer patients.

negative:
A deep learning method for classifying mammographic breast density categories. PURPOSE
Mammographic breast density is an established risk marker for breast cancer and is visually assessed by radiologists in routine mammogram image reading, using four qualitative Breast Imaging and Reporting Data System (BI-RADS) breast density categories. It is particularly difficult for radiologists to consistently distinguish the two most common and most variably assigned BI-RADS categories, i.e., "scattered density" and "heterogeneously dense". The aim of this work was to investigate a deep learning-based breast density classifier to consistently distinguish these two categories, aiming at providing a potential computerized tool to assist radiologists in assigning a BI-RADS category in current clinical workflow.

METHODS
In this study, we constructed a convolutional neural network (CNN)-based model coupled with a large (i.e., 22,000 images) digital mammogram imaging dataset to evaluate the classification performance between the two aforementioned breast density categories. All images were collected from a cohort of 1,427 women who underwent standard digital mammography screening from 2005 to 2016 at our institution. The truths of the density categories were based on standard clinical assessment made by board-certified breast imaging radiologists. Effects of direct training from scratch solely using digital mammogram images and transfer learning of a pretrained model on a large nonmedical imaging dataset were evaluated for the specific task of breast density classification. In order to measure the classification performance, the CNN classifier was also tested on a refined version of the mammogram image dataset by removing some potentially inaccurately labeled images. Receiver operating characteristic (ROC) curves and the area under the curve (AUC) were used to measure the accuracy of the classifier.

RESULTS
The AUC was 0.9421 when the CNN-model was trained from scratch on our own mammogram images, and the accuracy increased gradually along with an increased size of training samples. Using the pretrained model followed by a fine-tuning process with as few as 500 mammogram images led to an AUC of 0.9265. After removing the potentially inaccurately labeled images, AUC was increased to 0.9882 and 0.9857 for without and with the pretrained model, respectively, both significantly higher (P < 0.001) than when using the full imaging dataset.

CONCLUSIONS
Our study demonstrated high classification accuracies between two difficult to distinguish breast density categories that are routinely assessed by radiologists. We anticipate that our approach will help enhance current clinical assessment of breast density and better support consistent density notification to patients in breast cancer screening.

negative: Breast disorders in pregnant and lactating women. The breast undergoes extensive changes during pregnancy and lactation that can create diagnostic challenges. This article reviews the anatomy of the breast, breast changes associated with pregnancy and lactation, and breast imaging techniques for pregnant and lactating women. Various benign breast conditions in this patient population also are discussed, such as lactating adenomas, galactoceles, and granulomatous mastitis. Finally, pregnancy-associated breast cancer is presented, including its epidemiology, diagnosis, staging, treatment, and prognosis.

negative: Accessory Axillary Breast Tissues Dr. Emsen recently published a case report describing a patient with accessory axillary breast tissue treated with ultrasound-guided liposuction [3]. We recently treated a similar case of bilateral axillary breast tissue, and we offer our contribution to the debate (Figs. 1, 2). Accessory axillary breast tissues are common embriogenic alterations found in 1% to 6% of women that often manifest bilaterally [1,2]. Ectopic breast tissue is at risk for benign and malignant breast disease with reported diagnoses of fibrocystic disease, mastitis, fibroadenoma, atypical hyperplasia, and carcinoma [4 6]. In a review of 82 ectopic breast cancer cases, Marshall et al. [5] found an increased incidence of cancer in aberrant breast tissue. Ectopic cancers located in the axilla seemed to present with more extensive disease at an earlier age, suggesting that aberrant breast tissue may be at increased risk for malignant change. According to this view, as for any ectopic mass, tissue diagnosis is required and mandatory [4]. We recently treated a 43-year-old woman who was asymptomatic until her second pregnancy (2004), when two bilateral masses appeared in axillae and began to increase in size. Six months after parturition, a clear fluid was continuously secreted throughout few small pores on the skin. Ultrasounddiagnosed breast tissue and excision with histologic examination confirmed the radiologic findings. In this case, we preoperatively contemplated, as Dr. Emsen did, less invasive and aesthetic methods such as liposuction. However, a collegial discussion with our pathologist and an analysis of literature data suggested en bloc removal for a more precise analysis not only of cellular, but also of histologic characteristics of suspected mammary ducts. We believe that liposuction, more traumatic on tissues than simple excision, does not allow for this. Furthermore, although liposuction leaves minimal incision scars, the Fig. 1. A 43-year-old woman. Right axilla with accessory breast tissue.

negative:
Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials BACKGROUND
Lymphedema is a common complication of axillary dissection for breast cancer. We investigated whether manual lymphatic drainage (MLD) could prevent or manage limb edema in women after breast-cancer surgery.

METHODS
We performed a systematic review and meta-analysis of published randomized controlled trials (RCTs) to evaluate the effectiveness of MLD in the prevention and treatment of breast-cancer-related lymphedema. The PubMed, EMBASE, CINAHL, Physiotherapy Evidence Database (PEDro), SCOPUS, and Cochrane Central Register of Controlled Trials electronic databases were searched for articles on MLD published before December 2012, with no language restrictions. The primary outcome for prevention was the incidence of postoperative lymphedema. The outcome for management of lymphedema was a reduction in edema volume.

RESULTS
In total, 10 RCTs with 566 patients were identified. Two studies evaluating the preventive outcome of MLD found no significant difference in the incidence of lymphedema between the MLD and standard treatment groups, with a risk ratio of 0.63 and a 95% confidence interval (CI) of 0.14 to 2.82. Seven studies assessed the reduction in arm volume, and found no significant difference between the MLD and standard treatment groups, with a weighted mean difference of 75.12 (95% CI, -9.34 to 159.58).

CONCLUSIONS
The current evidence from RCTs does not support the use of MLD in preventing or treating lymphedema. However, clinical and statistical inconsistencies between the various studies confounded our evaluation of the effect of MLD on breast-cancer-related lymphedema.

negative: Review of Electromagnetic Techniques for Breast Cancer Detection Breast cancer is anticipated to be responsible for almost 40,000 deaths in the USA in 2011. The current clinical detection techniques suffer from limitations which motivated researchers to investigate alternative modalities for the early detection of breast cancer. This paper focuses on reviewing the main electromagnetic techniques for breast cancer detection. More specifically, this work reviews the cutting edge research in microwave imaging, electrical impedance tomography, diffuse optical tomography, microwave radiometry, biomagnetic detection, biopotential detection, and magnetic resonance imaging (MRI). The goal of this paper is to provide biomedical researchers with an in-depth review that includes all main electromagnetic techniques in the literature and the latest progress in each of these techniques.

negative:
Analysis of circulating tumor DNA to monitor metastatic breast cancer. BACKGROUND
The management of metastatic breast cancer requires monitoring of the tumor burden to determine the response to treatment, and improved biomarkers are needed. Biomarkers such as cancer antigen 15-3 (CA 15-3) and circulating tumor cells have been widely studied. However, circulating cell-free DNA carrying tumor-specific alterations (circulating tumor DNA) has not been extensively investigated or compared with other circulating biomarkers in breast cancer.

METHODS
We compared the radiographic imaging of tumors with the assay of circulating tumor DNA, CA 15-3, and circulating tumor cells in 30 women with metastatic breast cancer who were receiving systemic therapy. We used targeted or whole-genome sequencing to identify somatic genomic alterations and designed personalized assays to quantify circulating tumor DNA in serially collected plasma specimens. CA 15-3 levels and numbers of circulating tumor cells were measured at identical time points.

RESULTS
Circulating tumor DNA was successfully detected in 29 of the 30 women (97%) in whom somatic genomic alterations were identified; CA 15-3 and circulating tumor cells were detected in 21 of 27 women (78%) and 26 of 30 women (87%), respectively. Circulating tumor DNA levels showed a greater dynamic range, and greater correlation with changes in tumor burden, than did CA 15-3 or circulating tumor cells. Among the measures tested, circulating tumor DNA provided the earliest measure of treatment response in 10 of 19 women (53%).

CONCLUSIONS
This proof-of-concept analysis showed that circulating tumor DNA is an informative, inherently specific, and highly sensitive biomarker of metastatic breast cancer. (Funded by Cancer Research UK and others.).


query: Behavior of MVC (Model View Controller) based Web Application developed in PHP and .NET framework

positive: Use of Design Patterns in PHP-Based Web Application Frameworks It is known that design patterns of object-oriented programming are used in the design of Web applications, but there is no sufficient information which data patterns are used, how often they are used, and the level of quality at which they are used. This paper describes the results concerning the use of design patterns in projects which develop PHP-based Web application frameworks. Documentation and source code were analysed for 10 frameworks, finding that design patterns are used in the development of Web applications, but not too much and without much consistency. The results and conclusions can be of use when planning and developing new projects because the existing experience can be taken into account. The paper also offers information which design patterns are not used because they may be artificial or hard-to-use in real projects. Alternatively, developers may simply lack information on the existence of the design patterns.

positive: PHP FRAMEWORK FOR DATABASE MANAGEMENT BASED ON MVC PATTERN PHP is a powerful language to develop dynamic and interactive web applications. One of the defining features of PHP is the ease for developers to connect and manipulate a database. PHP prepares the functions for database manipulation. However, database management is done by the Structure Query Language (SQL). Most novice programmers often have trouble with SQL syntax. In this paper, we present the PHP framework for database management based on the MVC pattern. The MVC pattern is very useful for the architecture of web applications, separating the model, view and controller of a web application. The PHP framework encapsulated, common database operations are INSERT, UPDATE, DELETE and SELECT. Developers will not be required to consider the specific SQL statement syntax, just to call it the method in the model module. In addition, we use White-Box testing for the code verification in the model module. Lastly, a web application example is shown to illustrate the process of the PHP framework.

positive: Understanding and Using Patterns in Software Development Patterns have shown to be an effective means of capturing and communicating software design experience. However, there is more to patterns than software design patterns: We believe that patterns work for software development on several levels. In this paper we explore what we have come to understand as crucial aspects of the pattern concept, relate patterns to the different models built during software design, discuss pattern forms and how we think that patterns can form larger wholes like pattern handbooks.

positive: Patterns of Enterprise Application Architecture protected void doInsert(DomainObject subject, PreparedStatement insertStatement) throws SQLException; class PersonMapper... protected String insertStatement() { return "INSERT INTO people VALUES (?, ?, ?, ?)"; } protected void doInsert( DomainObject abstractSubject, PreparedStatement stmt) throws SQLException { Person subject = (Person) abstractSubject; stmt.setString(2, subject.getLastName()); stmt.setString(3, subject.getFirstName()); stmt.setInt(4, subject.getNumberOfDependents()); } Example: Separating the Finders (Java) To allow domain objects to invoke finder behavior I can use Separated Interface (476) to separate the finder interfaces from the mappers (Figure 10.5 ). I can put these finder interfaces in a separate package that's visible to the domain layer, or, as in this case, I can put them in the domain layer itself. Figure 10.5. Defining a finder interface in the domain package.

positive: The Research of PHP Development Framework Based on MVC Pattern PHP is one of the leading web development languages, however, the development model of existing PHP organizes without a structure, which mixes the code of data access, the processing of business logic , and web presentation layer together, as a relult, it brought about many problems in the web applications , meanwhile, it could not meet the rapid development of web apply any more. In this paper, a implementation of PHP based on MVC design patterns - FDF framework was provided for PHP developers, which can offer a framework for web applications, separate the data, view and control of web applications, afford to achieve loose coupling, thereby enhanced the efficiency, reliability, maintainability and scalability of application development.

negative: Co-regularized least square regression for multi-view multi-class classification Many classification problems involve instances that are unlabeled, multi-view and multi-class. However, few technique has been benchmarked for this complex scenario, with a notable exception that combines co-trained naive bayes (CoT-NB) with BCH coding. In this paper, we benchmark the performance of co-regularized least square regression (CoR-LS) for semi-supervised multi-view multi-class classification. We find it performed consistently and significantly better than CoT-NB over eight data sets at different scales. We also find for CoR-LS identity coding is optimal on large data sets and BCH coding is optimal on small data sets. Optimal scoring, a data-dependent coding scheme, often provides near-optimal performance.

negative:
Introduction to Fillers. BACKGROUND
Over the last few years, injectable soft-tissue fillers have become an integral part of cosmetic therapy, with a wide array of products designed to fill lines and folds and revolumize the face.

METHODS
This review describes cosmetic fillers currently approved by the Food and Drug Administration and discusses new agents under investigation for use in the United States.

RESULTS
Because of product refinements over the last few years-greater ease of use and longevity, the flexibility of multiple formulations within one line of products, and the ability to reverse poor clinical outcomes-practitioners have gravitated toward the use of biodegradable agents that stimulate neocollagenesis for sustained aesthetic improvements lasting up to a year or more with minimal side effects. Permanent implants provide long-lasting results but are associated with greater potential risk of complications and require the skilled hand of the experienced injector.

CONCLUSIONS
A variety of biodegradable and nonbiodegradable filling agents are available or under investigation in the United States. Choice of product depends on injector preference and the area to be filled. Although permanent agents offer significant clinical benefits, modern biodegradable fillers are durable and often reversible in the event of adverse effects.

negative: Truncated Importance Sampling for Reinforcement Learning with Experience Replay Reinforcement Learning (RL) is considered here as an adaptation technique of neural controllers of machines. The goal is to make Actor-Critic algorithms require less agent-environment interaction to obtain policies of the same quality, at the cost of additional background computations. We propose to achieve this goal in the spirit of experience replay. An estimation method of improvement direction of a changing policy, based on preceding experience, is essential here. We propose one that uses truncated importance sampling. We derive bounds of bias of that type of estimators and prove that this bias asymptotically vanishes. In the experimental study we apply our approach to the classic ActorCritic and obtain 20-fold increase in speed of learning.

negative: EmEx, a Tool for Automated Emotive Face Recognition Using Convolutional Neural Networks The work described in this paper represents the study and the attempt to make a contribution to one of the most stimulating and promising sectors in the field of emotion recognition, which is health care management. Multidisciplinary studies in artificial intelligence, augmented reality and psychology stressed out the importance of emotions in communication and awareness. The intent is to recognize human emotions, processing images streamed in real-time from a mobile device. The adopted techniques involve the use of open source libraries of visual recognition and machine learning approaches based on convolutional neural networks (CNN).

negative: A Novel Secure Architecture for the Internet of Things The "Internet of Things"(IoT) opens opportunities for devices and softwares to share information on an unprecedented scale. However, such a large interconnected network poses new challenges to system developers and users. In this article, we propose a layered architecture of IoT system. Using this model, we try to identify and assess each layer's challenges. We also discuss several existing technologies that can be used make this architecture secure.

negative: MIMO Performance of Realistic UE Antennas in LTE Scenarios at 750 MHz Multiple-input-multiple-output (MIMO) is a technique to achieve high data rates in mobile communication networks. Simulations are performed at both the antenna level and Long-Term Evolution (LTE) system level to assess the performance of realistic handheld devices with dual antennas at 750 MHz. It is shown that MIMO works very well and gives substantial performance gain in user devices with a quarter-wavelength antenna separation.

negative: Implementation and verification of a generic universal memory controller based on UVM This paper presents a coverage driven constraint random based functional verification method based on the Universal Verification Methodology (UVM) using System Verilog for generic universal memory controller architecture. This universal memory controller is looking forward to improving the performance of the existing memory controllers through a complete integration of the existing memory controllers features in addition of providing novel features. It also reduces the consumed power through providing high power consumption control due to its proposed different power levels supported to fit all power scenarios. While implementing a worthy architecture like the proposed generic universal memory controller, UVM is the best choice to build well-constructed, high controlled and reusable verification environment to efficiently verify it. More than 200 coverage points have been covered to verify the validation of the integrated features which makes the proposed universal memory controller replaces the existing controllers on the scene as it provides all of their powerful features in addition of novel features to control two of the most dominated types of memory; FLASH and DRAM through one memory controller.

negative: Towards Internet of Things : Survey and Future Vision Internet of things is a promising research due to its importance in many commerce, industry, and education applications. Recently, new applications and research challenges in numerous areas of Internet of things are fired. In this paper, we discuss the history of Internet of things, different proposed architectures of Internet of things, research challenges and open problems related to the Internet of things. We also introduce the concept of Internet of things database and discuss about the future vision of Internet of things. These are the manuscript preparation guidelines used as a standard template for all journal submissions. Author must follow these instructions while preparing/modifying these guidelines.

negative: Joint Semantic and Latent Attribute Modelling for Cross-Class Transfer Learning A number of vision problems such as zero-shot learning and person re-identification can be considered as cross-class transfer learning problems. As mid-level semantic properties shared cross different object classes, attributes have been studied extensively for knowledge transfer across classes. Most previous attribute learning methods focus only on human-defined/nameable semantic attributes, whilst ignoring the fact there also exist undefined/latent shareable visual properties, or latent attributes. These latent attributes can be either discriminative or non-discriminative parts depending on whether they can contribute to an object recognition task. In this work, we argue that learning the latent attributes jointly with user-defined semantic attributes not only leads to better representation but also helps semantic attribute prediction. A novel dictionary learning model is proposed which decomposes the dictionary space into three parts corresponding to semantic, latent discriminative and latent background attributes respectively. Such a joint attribute learning model is then extended by following a multi-task transfer learning framework to address a more challenging unsupervised domain adaptation problem, where annotations are only available on an auxiliary dataset and the target dataset is completely unlabelled. Extensive experiments show that the proposed models, though being linear and thus extremely efficient to compute, produce state-of-the-art results on both zero-shot learning and person re-identification.

negative: The Parallel Knowledge Gradient Method for Batch Bayesian Optimization In many applications of black-box optimization, one can evaluate multiple points simultaneously, e.g. when evaluating the performances of several different neural networks in a parallel computing environment. In this paper, we develop a novel batch Bayesian optimization algorithm — the parallel knowledge gradient method. By construction, this method provides the one-step Bayes optimal batch of points to sample. We provide an efficient strategy for computing this Bayes-optimal batch of points, and we demonstrate that the parallel knowledge gradient method finds global optima significantly faster than previous batch Bayesian optimization algorithms on both synthetic test functions and when tuning hyperparameters of practical machine learning algorithms, especially when function evaluations are noisy.

negative: The structure of musical preferences: a five-factor model. Music is a cross-cultural universal, a ubiquitous activity found in every known human culture. Individuals demonstrate manifestly different preferences in music, and yet relatively little is known about the underlying structure of those preferences. Here, we introduce a model of musical preferences based on listeners' affective reactions to excerpts of music from a wide variety of musical genres. The findings from 3 independent studies converged to suggest that there exists a latent 5-factor structure underlying music preferences that is genre free and reflects primarily emotional/affective responses to music. We have interpreted and labeled these factors as (a) a Mellow factor comprising smooth and relaxing styles; (b) an Unpretentious factor comprising a variety of different styles of sincere and rootsy music such as is often found in country and singer-songwriter genres; (c) a Sophisticated factor that includes classical, operatic, world, and jazz; (d) an Intense factor defined by loud, forceful, and energetic music; and (e) a Contemporary factor defined largely by rhythmic and percussive music, such as is found in rap, funk, and acid jazz. The findings from a fourth study suggest that preferences for the MUSIC factors are affected by both the social and the auditory characteristics of the music.

negative: Coagulation and ablation patterns of high-intensity focused ultrasound on a tissue-mimicking phantom and cadaveric skin High-intensity focused ultrasound (HIFU) can be applied noninvasively to create focused zones of tissue coagulation on various skin layers. We performed a comparative study of HIFU, evaluating patterns of focused tissue coagulation and ablation upon application thereof. A tissue-mimicking (TM) phantom was prepared with bovine serum albumin and polyacrylamide hydrogel to evaluate the geometric patterns of HIFU-induced thermal injury zones (TIZs) for five different HIFU devices. Additionally, for each device, we investigated histologic patterns of HIFU-induced coagulation and ablation in serial sections of cadaveric skin of the face and neck. All HIFU devices generated remarkable TIZs in the TM phantom, with different geometric values of coagulation for each device. Most of the TIZs seemed to be separated into two or more tiny parts. In cadaveric skin, characteristic patterns of HIFU-induced ablation and coagulation were noted along the mid to lower dermis at the focal penetration depth of 3 mm and along subcutaneous fat to the superficial musculoaponeurotic system or the platysma muscle of the neck at 4.5 mm. Additionally, remarkable pre-focal areas of tissue coagulation were observed in the upper and mid dermis at the focal penetration depth of 3 mm and mid to lower dermis at 4.5 mm. For five HIFU devices, we outlined various patterns of HIFU-induced TIZ formation along pre-focal, focal, and post-focal areas of TM phantom and cadaveric skin of the face and neck.

negative: Revising Immersion: A Conceptual Model for the Analysis of Digital Game Involvement Game studies literature has recently seen a renewed interest in game experience with the recent publication of a number of edited collections, dissertations and conferences focusing on the subject. This paper aims to contribute to that growing body of literature by presenting a summary of my doctoral research in digital game involvement and immersion. It outlines a segment of a conceptual model that describes and analyzes the moment by moment involvement with digital games on a variety of experiential dimensions corresponding to six broad categories of game features. The paper ends with a proposal to replace the metaphor of immersion with one of incorporation. Incorporation aims to avoid the binary notion of the player’s plunge into the virtual environment characteristic of “immersion” while dispelling the vagueness of application that all too often surrounds the term.

negative: SpatialHadoop: towards flexible and scalable spatial processing using mapreduce Recently, MapReduce frameworks, e.g., Hadoop, have been used extensively in different applications that include tera-byte sorting, machine learning, and graph processing. With the huge volumes of spatial data coming from different sources, there is an increasing demand to exploit the efficiency of Hadoop, coupled with the flexibility of the MapReduce framework, in spatial data processing. However, Hadoop falls short in supporting spatial data efficiently as the core is unaware of spatial data properties. This paper describes SpatialHadoop; a full-edged MapReduce framework with native support for spatial data. SpatialHadoop is a comprehensive extension to Hadoop that injects spatial data awareness in each Hadoop layer, namely, the language, storage, MapReduce, and operations layers. In the language layer, SpatialHadoop adds a simple and ex- pressive high level language for spatial data types and operations. In the storage layer, SpatialHadoop adapts traditional spatial index structures, Grid, R-tree and R+-tree, to form a two-level spatial index. SpatialHadoop enriches the MapReduce layer by two new components, SpatialFileSplitter and SpatialRecordReader, for efficient and scalable spatial data processing. In the operations layer, SpatialHadoop is already equipped with a dozen of operations, including range query, kNN, and spatial join. The flexibility and open source nature of SpatialHadoop allows more spatial operations to be implemented efficiently using MapReduce. Extensive experiments on a real system prototype and real datasets show that SpatialHadoop achieves orders of magnitude better performance than Hadoop for spatial data processing.

negative:
Impact of a workplace stress reduction program on blood pressure and emotional health in hypertensive employees. OBJECTIVES
This study examined the impact of a workplace-based stress management program on blood pressure (BP), emotional health, and workplace-related measures in hypertensive employees of a global information technology company.

DESIGN
Thirty-eight (38) employees with hypertension were randomly assigned to a treatment group that received the stress-reduction intervention or a waiting control group that received no intervention during the study period. The treatment group participated in a 16-hour program, which included instruction in positive emotion refocusing and emotional restructuring techniques intended to reduce sympathetic nervous system arousal, stress, and negative affect, increase positive affect, and improve performance. Learning and practice of the techniques was enhanced by heart rate variability feedback, which helped participants learn to self-generate physiological coherence, a beneficial physiologic mode associated with increased heart rhythm coherence, physiologic entrainment, parasympathetic activity, and vascular resonance. BP, emotional health, and workplace-related measures were assessed before and 3 months after the program.

RESULTS
Three months post-intervention, the treatment group exhibited a mean adjusted reduction of 10.6 mm Hg in systolic BP and of 6.3 mm Hg in diastolic BP. The reduction in systolic BP was significant in relation to the control group. The treatment group also demonstrated improvements in emotional health, including significant reductions in stress symptoms, depression, and global psychological distress and significant increases in peacefulness and positive outlook. Reduced systolic BP was correlated with reduced stress symptoms. Furthermore, the trained employees demonstrated significant increases in the work-related scales of workplace satisfaction and value of contribution.

CONCLUSIONS
Results suggest that a brief workplace stress management intervention can produce clinically significant reductions in BP and improve emotional health among hypertensive employees. Implications are that such interventions may produce a healthier and more productive workforce, enhancing performance and reducing losses to the organization resulting from cognitive decline, illness, and premature mortality.

negative: IL-17 and Th17 Cells. CD4+ T cells, upon activation and expansion, develop into different T helper cell subsets with different cytokine profiles and distinct effector functions. Until recently, T cells were divided into Th1 or Th2 cells, depending on the cytokines they produce. A third subset of IL-17-producing effector T helper cells, called Th17 cells, has now been discovered and characterized. Here, we summarize the current information on the differentiation and effector functions of the Th17 lineage. Th17 cells produce IL-17, IL-17F, and IL-22, thereby inducing a massive tissue reaction owing to the broad distribution of the IL-17 and IL-22 receptors. Th17 cells also secrete IL-21 to communicate with the cells of the immune system. The differentiation factors (TGF-beta plus IL-6 or IL-21), the growth and stabilization factor (IL-23), and the transcription factors (STAT3, RORgammat, and RORalpha) involved in the development of Th17 cells have just been identified. The participation of TGF-beta in the differentiation of Th17 cells places the Th17 lineage in close relationship with CD4+CD25+Foxp3+ regulatory T cells (Tregs), as TGF-beta also induces differentiation of naive T cells into Foxp3+ Tregs in the peripheral immune compartment. The investigation of the differentiation, effector function, and regulation of Th17 cells has opened up a new framework for understanding T cell differentiation. Furthermore, we now appreciate the importance of Th17 cells in clearing pathogens during host defense reactions and in inducing tissue inflammation in autoimmune disease.

negative: Variational mesh segmentation via quadric surface fitting Wepresent a new variationalmethod formesh segmentation by fitting quadric surfaces. Each component of the resulting segmentation is represented by a general quadric surface (including plane as a special case). A novel energy function is defined to evaluate the quality of the segmentation, which combines both L2 and L2,1 metrics from a triangle to a quadric surface. The Lloyd iteration is used to minimize the energy function, which repeatedly interleaves between mesh partition and quadric surface fitting. We also integrate feature-based and simplification-based techniques in the segmentation framework, which greatly improve the performance. The advantages of our algorithm are demonstrated by comparing with the state-of-the-art methods. © 2012 Elsevier Ltd. All rights reserved.

negative: Extracting Opinion Expressions with semi-Markov Conditional Random Fields Extracting opinion expressions from text is usually formulated as a token-level sequence labeling task tackled using Conditional Random Fields (CRFs). CRFs, however, do not readily model potentially useful segment-level information like syntactic constituent structure. Thus, we propose a semi-CRF-based approach to the task that can perform sequence labeling at the segment level. We extend the original semi-CRF model (Sarawagi and Cohen, 2004) to allow the modeling of arbitrarily long expressions while accounting for their likely syntactic structure when modeling segment boundaries. We evaluate performance on two opinion extraction tasks, and, in contrast to previous sequence labeling approaches to the task, explore the usefulness of segmentlevel syntactic parse features. Experimental results demonstrate that our approach outperforms state-of-the-art methods for both opinion expression tasks.

negative: The GUM corpus: creating multilayer resources in the classroom This paper presents the methodology, design principles and detailed evaluation of a new freely available multilayer corpus, collected and edited via classroom annotation using collaborative software. After briefly discussing corpus design for open, extensible corpora, five classroom annotation projects are presented, covering structural markup in TEI XML, multiple part of speech tagging, constituent and dependency parsing, information structural and coreference annotation, and Rhetorical Structure Theory analysis. Layers are inspected for annotation quality and together they coalesce to form a richly annotated corpus that can be used to study the interactions between different levels of linguistic description. The evaluation gives an indication of the expected quality of a corpus created by students with relatively little training. A multifactorial example study on lexical NP coreference likelihood is also presented, which illustrates some applications of the corpus. The results of this project show that high quality, richly annotated resources can be created effectively as part of a linguistics curriculum, opening new possibilities not just for research, but also for corpora in linguistics pedagogy.

negative: Programming challenges of chatbot: Current and future prospective In the modern Era of technology, Chatbots is the next big thing in the era of conversational services. Chatbots is a virtual person who can effectively talk to any human being using interactive textual skills. Currently, there are many cloud base Chatbots services which are available for the development and improvement of the chatbot sector such as IBM Watson, Microsoft bot, AWS Lambda, Heroku and many others. A virtual person is based on machine learning and Artificial Intelligence (AI) concepts and due to dynamic nature, there is a drawback in the design and development of these chatbots as they have built-in AI, NLP, programming and conversion services. This paper gives an overview of cloud-based chatbots technologies along with programming of chatbots and challenges of programming in current and future Era of chatbot.

negative: Situationally Aware In-Car Information Presentation Using Incremental Speech Generation: Safer, and More Effective Holding non-co-located conversations while driving is dangerous (Horrey and Wickens, 2006; Strayer et al., 2006), much more so than conversations with physically present, “situated” interlocutors (Drews et al., 2004). In-car dialogue systems typically resemble non-co-located conversations more, and share their negative impact (Strayer et al., 2013). We implemented and tested a simple strategy for making in-car dialogue systems aware of the driving situation, by giving them the capability to interrupt themselves when a dangerous situation is detected, and resume when over. We show that this improves both driving performance and recall of system-presented information, compared to a non-adaptive strategy.

negative: Predictive maintenance techniques This article discusses the importance of PdM for industrial process applications and investigates a number of emerging technologies that enable this approach, including online energy-efficiency evaluation and continuous condition monitoring. The article gives an overview of existing and future technologies that can be used in these areas. Two methods for bearing fault detection and energy-efficiency estimation are discussed. The article concludes with focus on one pilot installation at Weyerhaeuser's Containerboard Packaging Plant in Manitowoc, Wisconsin, USA, monitoring three critical induction motors: a 75-hrho blower motor, a 50-hrho hydraulic pump motor, and a 200-hp compressor motor. Finally, the field experience gained in this plant is presented as two case studies.

negative: Spectral analysis of surface electromyography (EMG) of upper esophageal sphincter-opening muscles during head lift exercise. Although recent studies have shown enhancement of deglutitive upper esophageal sphincter opening in healthy elderly patients performing an isometric/isotonic head lift exercise (HLE), the muscle groups affected by this process are not known. A shift in the spectral analysis of surface EMG activity seen with muscle fatigue can be used to identify muscles affected by an exercise. The objective of this study was to use spectral analysis to evaluate surface EMG activities in the suprahyoid (SHM), infrahyoid (IHM), and sternocleidomastoid (SCM) muscle groups during the HLE. Surface EMG signals were recorded continuously on a TECA Premiere II during two phases of the HLE protocol in eleven control subjects. In the first phase of the protocol, surface EMG signals were recorded simultaneously from the three muscle groups for a period of 20 s. In the second phase, a 60 s recording was obtained for each of three successive trials with individual muscle groups. The mean frequency (MNF), median frequency (MDF), root mean square (RMS), and average rectified value (ARV) were used as spectral variables to assess the fatigue of the three muscle groups during the exercise. Least squares regression lines were fitted to each variable data set. Our findings suggest that during the HLE the SHM, IHM, and SCM muscle groups all show signs of fatigue; however, the SCM muscle group fatigued faster than the SHM and IHM muscle groups. Because of its higher fatigue rate, the SCM muscle group may play a limiting role in the HLE.

negative:
ZStream: a cost-based query processor for adaptively detecting composite events Composite (or Complex) event processing (CEP) systems search sequences of incoming events for occurrences of user-specified event patterns. Recently, they have gained more attention in a variety of areas due to their powerful and expressive query language and performance potential. Sequentiality (temporal ordering) is the primary way in which CEP systems relate events to each other. In this paper, we present a CEP system called ZStream to efficiently process such sequential patterns. Besides simple sequential patterns, ZStream is also able to detect other patterns, including conjunction, disjunction, negation and Kleene closure.
 Unlike most recently proposed CEP systems, which use non-deterministic finite automata (NFA's) to detect patterns, ZStream uses tree-based query plans for both the logical and physical representation of query patterns. By carefully designing the underlying infrastructure and algorithms, ZStream is able to unify the evaluation of sequence, conjunction, disjunction, negation, and Kleene closure as variants of the join operator. Under this framework, a single pattern in ZStream may have several equivalent physical tree plans, with different evaluation costs. We propose a cost model to estimate the computation costs of a plan. We show that our cost model can accurately capture the actual runtime behavior of a plan, and that choosing the optimal plan can result in a factor of four or more speedup versus an NFA based approach. Based on this cost model and using a simple set of statistics about operator selectivity and data rates, ZStream is able to adaptively and seamlessly adjust the order in which it detects patterns on the fly. Finally, we describe a dynamic programming algorithm used in our cost model to efficiently search for an optimal query plan for a given pattern.

negative: Environmental implications of plastic debris in marine settings--entanglement, ingestion, smothering, hangers-on, hitch-hiking and alien invasions. Over the past five or six decades, contamination and pollution of the world's enclosed seas, coastal waters and the wider open oceans by plastics and other synthetic, non-biodegradable materials (generally known as 'marine debris') has been an ever-increasing phenomenon. The sources of these polluting materials are both land- and marine-based, their origins may be local or distant, and the environmental consequences are many and varied. The more widely recognized problems are typically associated with entanglement, ingestion, suffocation and general debilitation, and are often related to stranding events and public perception. Among the less frequently recognized and recorded problems are global hazards to shipping, fisheries and other maritime activities. Today, there are rapidly developing research interests in the biota attracted to freely floating (i.e. pelagic) marine debris, commonly known as 'hangers-on and hitch-hikers' as well as material sinking to the sea floor despite being buoyant. Dispersal of aggressive alien and invasive species by these mechanisms leads one to reflect on the possibilities that ensuing invasions could endanger sensitive, or at-risk coastal environments (both marine and terrestrial) far from their native habitats.

negative: MVC architecture driven restructuring to achieve client-side web page composition This paper presents a restructuring approach to relocating web page composition from servers to browsers for Java web applications. The objective is to reduce redundant manipulation and transfer of code/data that are shared by web pages. The reduction is carried out through a restructuring algorithm, effectively keeping consistency between source and target applications from the perspective of the model-view-controller (MVC) architecture, because the problem requires the target application to preserve the observable behavior of its source application. Case studies show that our restructuring tool can efficiently support the restructuring process.

negative: DATS - Data Containers for Web Applications Data containers enable users to control access to their data while untrusted applications compute on it. However, they require replicating an application inside each container - compromising functionality, programmability, and performance. We propose DATS - a system to run web applications that retains application usability and efficiency through a mix of hardware capability enhanced containers and the introduction of two new primitives modeled after the popular model-view-controller (MVC) pattern. (1) DATS introduces a templating language to create views that compose data across data containers. (2) DATS uses authenticated storage and confinement to enable an untrusted storage service, such as memcached and deduplication, to operate on plain-text data across containers. These two primitives act as robust declassifiers that allow DATS to enforce non-interference across containers, taking large applications out of the trusted computing base (TCB). We showcase eight different web applications including Gitlab and a Slack-like chat, significantly improve the worst-case overheads due to application replication, and demonstrate usable performance for common-case usage.

negative: A mobile application framework for the geospatial web In this paper we present an application framework that leverages geospatial content on the World Wide Web by enabling innovative modes of interaction and novel types of user interfaces on advanced mobile phones and PDAs. We discuss the current development steps involved in building mobile geospatial Web applications and derive three technological pre-requisites for our framework: spatial query operations based on visibility and field of view, a 2.5D environment model, and a presentationindependent data exchange format for geospatial query results. We propose the Local Visibility Model as a suitable XML-based candidate and present a prototype implementation.

negative: An Approach to Capture Role-Based Access Control Models from Spring Web Applications To mitigate potential misinterpretation and security violations, software developers should use tools that reflect the state of web applications and visualise them as graphical models. Modelling helps to ensure that functionality and access control mechanisms are consistently interconnected. In this paper, we propose an approach to support Web application development using the Spring platform. Our proposal is supported by the Eclipse IDE plugin tool, which recognises Spring Security configuration captures, its notations, and visualises them in the role-based access control (RBAC) models. The RBAC models are represented using SecureUML modelling language. The plugin is validated through survey taken by software developers.

negative: A Systematic Analysis of XSS Sanitization in Web Application Frameworks While most research on XSS defense has focused on techniques for securing existing applications and re-architecting browser mechanisms, sanitization remains the industry-standard defense mechanism. By streamlining and automating XSS sanitization, web application frameworks stand in a good position to stop XSS but have received little research attention. In order to drive research on web frameworks, we systematically study the security of the XSS sanitization abstractions frameworks provide. We develop a novel model of the web browserions frameworks provide. We develop a novel model of the web browser and characterize the challenges of XSS sanitization. Based on the model, we systematically evaluate the XSS abstractions in 14 major commercially-used web frameworks. We find that frameworks often do not address critical parts of the XSS conundrum. We perform an empirical analysis of 8 large web applications to extract the requirements of sanitization primitives from the perspective of realworld applications. Our study shows that there is a wide gap between the abstractions provided by frameworks and the requirements of applications.

negative: DESIGN AND IMPLEMENTATION OF A VIRTUAL CLASSROOM SYSTEM In the last few decades, education has witnessed some advances in technologies involving computeraided learning that promises to drastically change the methods of teaching and learning. The World Wide Web has played a major role in information storage and dissemination in the educational community. Conventional classroom based teaching involves the delivery of course materials by the lecturer in a particular place at a defined time. Hence it imposes a constraint of time and place on both the instructor and the student. Due to human factor arising from the traditional classroom method, the lecturer may not always be able to put in optimum effort towards preparing and delivering course materials. There may also be inconsistencies in the pedagogy and learning style due to repetitive nature of teaching/learning. The objective of this paper is to develop a virtual classroom system to enhance learning on campus. The system was developed using PHP and MySQL as server side programming and database respectively. The web-based virtual classroom provides a web enabled interactive model for e-learning in which the course material is presented using multimedia and hypermedia.

negative: GIST: A Model for Design and Management of Content and Interactivity of Customer-Centric Web Sites Customer-centric Web-based systems, such as ecommerce Web sites, or sites that support customer relationship management (CRM) activities, are themselves information systems, but their design and maintenance need to follow vastly different approaches from the traditional systems lifecycle approach. Based on marketing frameworks that are applicable to the online world, and following design science principles, we develop a model to guide the design and the continuous management of such sites. The model makes extensive use of current technologies for tracking the customers and their behaviors, and combines elements of data mining and statistical analyses. A case study based on a financial services Web site is used to provide a preliminary validation and design evaluation of our approach. The case study showed considerable measured improvement in the effectiveness of the companys Web site. In addition, it also highlighted an important benefit of the our approach: the identification of previously unknown or unexpected segments of visitors. This finding can lead to promising new business opportunities.