I hope not, one would hope that psychotherapy would improve the response but one doesn't know and of course I don't think we actually know whether the sensitivity to Psilocybin will be different in people with depression you could argue it both ways so in fact in the depression study we're going to use a low dose first just in case but if anyone here's got experience of using Psilocybin in depressed people and can reassure us that they're not super-sensitive 