And these receptors are profoundly concentrated in these areas of the brain that make up the default mode network and maybe to address one of the questions that was raised from the floor the way we're conceptualising what these receptors are doing now is that they clearly don't affect, unless perhaps they are extraordinarily stimulated, they don't affect memory they don't effect even the ability to respond to perceptions and sensory inputs but they certainly change the way in which you integrate sensory inputs with other experiences. 