But these are the two individuals who, these are the two most important Nobel prizes in the history of medicine and they were both gained under the influence of LSD where people used, these two individuals used it to solve what at the time were insoluable problems so working out the crystal structure of the double helix is not trivial and in fact it was very difficult but one suspects that Crick got insights from taking LSD when it was normal of course, when it was legal of course and one of the real challenges to us today is the fact that the illegality of these drugs has profoundly distorted research and is continuing to do so to a point where I think it's actually one of the greatest insults to modern research 