Kind of highlighting all the side effects of these older agents, some of the key points are the sedation, the anticholinergic side effects, a lot of constipation, dry mouth is very common with these, I talked about the cardiac issues, there is some QTC prolongation with these agents, especially when we start adding them into other drugs also with issues with QTC prolongation; the extrapyrmaidal side effects are important to address... these are things like an acute dystonic reaction, so where the patient is having a sudden onset where they have a dystonia and they can't move, we need to address that in a fast management situation with an anticholinergic and an IM formulation, akathesia which is constant restlessness where they can't sit still anymore, and that's usually a dose related phenomenon so we'd need to address that with a dose reduction, and that can be a sticky situation and often times something 