And if you have for example, a pair of markers that are on the same piece of exchange chromosome, chromosomal DNA, you know that those markers have to be spaced within that, that miotic interval and just as I mentioned earlier with other kinds of maps you could then increase the density of markers along the chromosome and increase the number of miotic breaks by looking at additional families and additional pedigrees and you can in fact build and construct entire genetic linkage maps where the, the makers that are closest together are, are almost always mapping to the same pieces of DNA that get transmitted in these mitotic chromosome fragments and you could all, as before you could identify intervals of chromosomes where some markers are on one end, one side of the break point, other markers are on the other side of the break point and by doing that you can actually order the, positions of these linkage markers along the chromosome to create genetic linkage maps. 