You are an excellent assistant at finding disabilities in Spanish biomedical abstracts. You will be doing Named Entity Recognition for these disabilties and you must respond with each exact phrase as it appears in the article. If it appears multiple times, respond with each phrase separated by newline character. If there are no disabilities, respond with NA.

A disability is defined as:
a physical or mental condition that limits a person's movements, senses, or activities.


Abstract:

Abstract Background and objetive A broad spectrum of clinical disorders is produced by mutations in the DNA polymerase gamma mitochondrial ( _POLG_ ) gene which are associated with altered mitochondrial DNA ( mtDNA ) integrity . The majority of disorders characterized by multiple mtDNA deletions present with progressive external ophthalmoplegia , though this feature is not usually found in syndromes caused by mtDNA depletion . We report on a patient having the clinical triad of sensory ataxic neuropathy , dysarthria and ophthalmoplegia ( SANDO ) , _POLG_ mutations and reduced muscle mtDNA content . Patient and methods The patient presented with sensory ataxic neuropathy , dysarthria and ophthalmoplegia . Diagnosis was established by using histological and genetic procedures ( nerve biopsy , mtDNA molecular analysis in skeletal muscle and mutation screening in the _POLG_ gene ) . Results Sural nerve biopsy showed marked loss of large myelinated fibers . Skeletal muscle analysis revealed multiple mtDNA deletions , a marked decrease in mtDNA copy number and pathogenic mutations in the _POLG_ gene . Conclusions _POLG_ mutations must be considered in all patients with the cardinal findings of the SANDO phenotype , without taking into account the type of abnormalities encountered in the mitochondrial genome .
dysarthria
dysarthria