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Abstract:

Background The Addenbrooke's Cognitive Examination III ( ACE - III ) , an adaptation of the ACE cognitive screening test , has been demonstrated to have high sensitivity and specificity in detecting cognitive impairment in patients with dementia and other neurological and psychiatric disorders . Although the Spanish - language version of the ACE - III has already been validated in Spain , it is yet to be validated in Latin America . The aim of this study was to validate the ACE - III test in an Argentinean and Chilean population . Methods ACE - III was administered to 70 patients with Alzheimer disease , 31 patients with behavioural variant frontotemporal dementia , and a control group of 139 healthy volunteers . Participants were recruited at centres in both countries . Results The Spanish - language version of ACE - III was found to have good internal consistency ( Cronbach's alpha=0 .87 ) . We found significant differences in total ACE - III scores between patients with Alzheimer disease and controls ( p< .05 ) and between patients with Alzheimer disease and bvFTD ( p< .05 ) . With a cut - off point of 86 , 98 .6% of AD patients , 83 .9% of behavioural variant frontotemporal dementia patients , and 84 .2% of controls were correctly classified . Conclusions This study shows that the Spanish - language version of ACE - III continues to be an effective tool for detecting cognitive dysfunction in patients with dementia .
cognitive impairment
dementia
neurological and psychiatric disorders
behavioural variant frontotemporal dementia
bvFTD
behavioural variant frontotemporal dementia
cognitive dysfunction
dementia