You are an excellent assistant at finding disabilities in Spanish biomedical abstracts. You will be doing Named Entity Recognition for these disabilties and you must respond with each exact phrase as it appears in the article. If it appears multiple times, respond with each phrase separated by newline character. If there are no disabilities, respond with NA.

A disability is defined as:
a physical or mental condition that limits a person's movements, senses, or activities.


Abstract:

Introduction In humans and animal models , Alzheimer disease ( AD ) is characterised by accumulation of amyloid - β peptide ( Aβ ) and hyperphosphorylated tau protein , neuronal degeneration , and astrocytic gliosis , especially in vulnerable brain regions ( hippocampus and cortex ) . These alterations are associated with cognitive impairment ( loss of memory ) and non - cognitive impairment ( motor impairment ) . The purpose of this study was to identify cell changes ( neurons and glial cells ) and aggregation of Aβ and hyperphosphorylated tau protein in the primary motor cortex ( M1 ) in 3xTg - AD mouse models at an intermediate stage of AD . Methods We used female 3xTg - AD mice aged 11 months and compared them to non - transgenic mice of the same age . In both groups , we assessed motor performance ( open field test ) and neuronal damage in M1 using specific markers : BAM10 ( extracellular Aβ aggregates ) , tau 499 ( hyperphosphorylated tau protein ) , GFAP ( astrocytes ) , and Klüver - Barrera staining ( neurons ) . Results Female 3xTg - AD mice in intermediate stages of the disease displayed motor and cellular alterations associated with Aβ and hyperphosphorylated tau protein deposition in M1 . Conclusions Patients with AD display signs and symptoms of functional impairment from early stages . According to our results , M1 cell damage in intermediate - stage AD affects motor function , which is linked to progression of the disease .
cognitive impairment
loss of memory
non - cognitive impairment
motor impairment
functional impairment