桔梗에 의한 NCI-H460 인체 비소세포폐암 세포에서의 autophagy 및 apoptosis 유발 효과
Su-hyun Hong, Min-ho Han, Cheol Park, Sang-eun Park, Sang-hoon Hong, Yung-hyun Choi
The Journal of Internal Korean Medicine > Volume 35(3); 2014 > Article
The Journal of Internal Korean Medicine 2014;35(3): 317-331.
홍수현1, 한민호1, 박철2, 박상은3, 홍상훈3, 최영현1,4
1동의대학교 한의과대학 생화학교실
2동의대학교 자연생활과학대학 분자생물학과
3동의대학교 한의과대학 한방내과
4동의대학교 항노화연구소 및 블루바이오소재개발센터
Su-hyun Hong1, Min-ho Han1, Cheol Park2, Sang-eun Park3, Sang-hoon Hong3, Yung-hyun Choi1,4
1Dept. of Biochemistry, College of Korean Medicine, Dong-eui University
2Dept. of Molecular Biology, College of Natural Science and Human Ecology, Dong-eui University
3Dept. of Korean Internal Medicine, College of Korean Medicine, Dong-eui University
4Anti-Aging Research Center & Blue-Bio Industry RIC, Dong-eui University
Correspondence Su-hyun Hong ,Tel: 051-850-8644, Fax: 051-853-4036, Email: hongsh@deu.ac.kr
Published online: September 30, 2014.
Our results suggest that PG elicited both autophagy and apoptosis by increasing loss of MMP and ROS production. PG induced-autophagy may play a cell protective role. [This research was supported by Basic Science Research Program through the NRF grant funded by the Korea government(No.2013R1A1A2065537).
Key words: Platycodong grandiflorum, Autophagy, Apoptosis, ROS, MMP
Effect of Gamisamgibopae-tang on the Growth and Apoptosis of A539 and NCI-H460 Human Lung Cancer Cells 2008 March;29(1)
Inhibition of Cell Proliferation and Induction of Apoptosis by Methanolic Extract of Aconiti Tuber in Human Renal Cell Carcinoma Cells 2008 March;29(1)
Induction of Apoptosis by Samgibopae-tang in Human Non-small-cell Lung Cancer Cells 2007 September;28(3)