<P> Activated p53 binds DNA and activates expression of several genes including microRNA miR - 34a , WAF1 / CIP1 encoding for p21 and hundreds of other down - stream genes . p21 ( WAF1 ) binds to the G1 - S / CDK ( CDK4 / CDK6 , CDK2 , and CDK1 ) complexes ( molecules important for the G1 / S transition in the cell cycle ) inhibiting their activity . </P>
<P> Activated p53 binds DNA and activates expression of several genes including microRNA miR - 34a , WAF1 / CIP1 encoding for p21 and hundreds of other down - stream genes . p21 ( WAF1 ) binds to the G1 - S / CDK ( CDK4 / CDK6 , CDK2 , and CDK1 ) complexes ( molecules important for the G1 / S transition in the cell cycle ) inhibiting their activity . </P>
what stage of the cell cycle does p53 work
what stage of the cell cycle does p53 work
G1 / S transition
G1 / S transition