<P> The CYP3A4 protein localizes to the endoplasmic reticulum , and its expression is induced by glucocorticoids and some pharmacological agents . Cytochrome P450 enzymes metabolize approximately 60 % of prescribed drugs , CYP3A4 is responsible for about half of this metabolism , substrates include acetaminophen , codeine , ciclosporin ( cyclosporin ) , diazepam , and erythromycin . The enzyme also metabolizes some steroids and carcinogens . Most drugs undergo deactivation by CYP3A4 , either directly or by facilitated excretion from the body . Also , many substances are bioactivated by CYP3A4 to form their active compounds , and many protoxins being toxicated into their toxic forms ( for examples -- see table below ) . </P>
<P> The CYP3A4 protein localizes to the endoplasmic reticulum , and its expression is induced by glucocorticoids and some pharmacological agents . Cytochrome P450 enzymes metabolize approximately 60 % of prescribed drugs , CYP3A4 is responsible for about half of this metabolism , substrates include acetaminophen , codeine , ciclosporin ( cyclosporin ) , diazepam , and erythromycin . The enzyme also metabolizes some steroids and carcinogens . Most drugs undergo deactivation by CYP3A4 , either directly or by facilitated excretion from the body . Also , many substances are bioactivated by CYP3A4 to form their active compounds , and many protoxins being toxicated into their toxic forms ( for examples -- see table below ) . </P>
drugs that are substrates of cytochrome p450 3a4 and cyp2d6
drugs that are substrates of cytochrome p450 3a4 and cyp2d6
acetaminophen codeine ciclosporin ( cyclosporin ) diazepam erythromycin
acetaminophen codeine ciclosporin ( cyclosporin ) diazepam erythromycin