<P> The first season of the American television medical drama Grey 's Anatomy , began airing in the United States on the American Broadcasting Company ( ABC ) on March 27 , 2005 , and concluded on May 22 , 2005 . The first season introduces the main character , Meredith Grey , as she enrolls in Seattle Grace Hospital 's internship program and faces unexpected challenges and surprises . Season one had nine series regulars , four of whom have been part of the main cast ever since . The season initially served as a mid-season replacement for the legal drama Boston Legal , airing in the Sunday night time slot at 10 : 00 , after Desperate Housewives . Although no clip shows have been produced for this season , the events that occur are recapped in `` Straight to Heart '' , a clip - show which aired one week before the winter holiday hiatus of the second season ended . The season was officially released on DVD as two - disc Region 1 box set under the title of Grey 's Anatomy : Season One on February 14 , 2006 , by Buena Vista Home Entertainment . </P>
<P> The first season of the American television medical drama Grey 's Anatomy , began airing in the United States on the American Broadcasting Company ( ABC ) on March 27 , 2005 , and concluded on May 22 , 2005 . The first season introduces the main character , Meredith Grey , as she enrolls in Seattle Grace Hospital 's internship program and faces unexpected challenges and surprises . Season one had nine series regulars , four of whom have been part of the main cast ever since . The season initially served as a mid-season replacement for the legal drama Boston Legal , airing in the Sunday night time slot at 10 : 00 , after Desperate Housewives . Although no clip shows have been produced for this season , the events that occur are recapped in `` Straight to Heart '' , a clip - show which aired one week before the winter holiday hiatus of the second season ended . The season was officially released on DVD as two - disc Region 1 box set under the title of Grey 's Anatomy : Season One on February 14 , 2006 , by Buena Vista Home Entertainment . </P>
when was the first episode of greys anatomy aired
when was the first episode of greys anatomy aired
March 27 , 2005
March 27 , 2005