<P> In the series , the character 's unorthodox diagnostic approaches , radical therapeutic motives , and stalwart rationality have resulted in much conflict between him and his colleagues . House is also often portrayed as lacking sympathy for his patients , a practice that allots him time to solve pathological enigmas . The character is partly inspired by Sherlock Holmes . A portion of the show 's plot centers on House 's habitual use of Vicodin to manage pain stemming from a leg infarction involving his quadriceps muscle some years earlier , an injury that forces him to walk with a cane . This addiction is also one of the many parallels to Holmes , who was a habitual user of cocaine . </P>
<P> In the series , the character 's unorthodox diagnostic approaches , radical therapeutic motives , and stalwart rationality have resulted in much conflict between him and his colleagues . House is also often portrayed as lacking sympathy for his patients , a practice that allots him time to solve pathological enigmas . The character is partly inspired by Sherlock Holmes . A portion of the show 's plot centers on House 's habitual use of Vicodin to manage pain stemming from a leg infarction involving his quadriceps muscle some years earlier , an injury that forces him to walk with a cane . This addiction is also one of the many parallels to Holmes , who was a habitual user of cocaine . </P>
what is wrong with dr house 's leg
what is wrong with dr house 's leg
a leg infarction involving his quadriceps muscle
a leg infarction involving his quadriceps muscle