<P> Acetyl - CoA is formed into malonyl - CoA by acetyl - CoA carboxylase , at which point malonyl - CoA is destined to feed into the fatty acid synthesis pathway . Acetyl - CoA carboxylase is the point of regulation in saturated straight - chain fatty acid synthesis , and is subject to both phosphorylation and allosteric regulation . Regulation by phosphorylation occurs mostly in mammals , while allosteric regulation occurs in most organisms . Allosteric control occurs as feedback inhibition by palmitoyl - CoA and activation by citrate . When there are high levels of palmitoyl - CoA , the final product of saturated fatty acid synthesis , it allosterically inactivates acetyl - CoA carboxylase to prevent a build - up of fatty acids in cells . Citrate acts to activate acetyl - CoA carboxylase under high levels , because high levels indicate that there is enough acetyl - CoA to feed into the Krebs cycle and produce energy . </P>
<P> Acetyl - CoA is formed into malonyl - CoA by acetyl - CoA carboxylase , at which point malonyl - CoA is destined to feed into the fatty acid synthesis pathway . Acetyl - CoA carboxylase is the point of regulation in saturated straight - chain fatty acid synthesis , and is subject to both phosphorylation and allosteric regulation . Regulation by phosphorylation occurs mostly in mammals , while allosteric regulation occurs in most organisms . Allosteric control occurs as feedback inhibition by palmitoyl - CoA and activation by citrate . When there are high levels of palmitoyl - CoA , the final product of saturated fatty acid synthesis , it allosterically inactivates acetyl - CoA carboxylase to prevent a build - up of fatty acids in cells . Citrate acts to activate acetyl - CoA carboxylase under high levels , because high levels indicate that there is enough acetyl - CoA to feed into the Krebs cycle and produce energy . </P>
where do fatty acids enter the krebs cycle
where do fatty acids enter the krebs cycle
fatty acid synthesis pathway
fatty acid synthesis pathway