<P> Laura Elizabeth `` Laurie '' Metcalf ( born June 16 , 1955 ) is an American actress . She is known for her television roles as Jackie Harris on the ABC sitcom Roseanne ( 1988 -- 97 ) ; Carolyn Bigsby on Desperate Housewives ( 2006 ) ; the recurring role of Mary Cooper on The Big Bang Theory ( 2007 -- present ) ; Dr. Jenna James on Getting On ( 2013 -- 15 ) , and Marjorie McCarthy in The McCarthys ( 2014 -- 15 ) . She voiced the role of Mrs. Davis in the Toy Story film series . Her other film appearances include Making Mr. Right ( 1987 ) , JFK ( 1991 ) , Mistress ( 1992 ) , and as Debbie Salt / Mrs. Loomis in Scream 2 ( 1997 ) . She has also appeared in commercials for Plan USA , a humanitarian organization which helps children in need around the world . </P>
<P> Laura Elizabeth `` Laurie '' Metcalf ( born June 16 , 1955 ) is an American actress . She is known for her television roles as Jackie Harris on the ABC sitcom Roseanne ( 1988 -- 97 ) ; Carolyn Bigsby on Desperate Housewives ( 2006 ) ; the recurring role of Mary Cooper on The Big Bang Theory ( 2007 -- present ) ; Dr. Jenna James on Getting On ( 2013 -- 15 ) , and Marjorie McCarthy in The McCarthys ( 2014 -- 15 ) . She voiced the role of Mrs. Davis in the Toy Story film series . Her other film appearances include Making Mr. Right ( 1987 ) , JFK ( 1991 ) , Mistress ( 1992 ) , and as Debbie Salt / Mrs. Loomis in Scream 2 ( 1997 ) . She has also appeared in commercials for Plan USA , a humanitarian organization which helps children in need around the world . </P>
who plays sheldons sister on big bang theory
who plays sheldons sister on big bang theory
Laura Elizabeth `` Laurie '' Metcalf
Laura Elizabeth `` Laurie '' Metcalf