<P> HRS can affect individuals with cirrhosis , severe alcoholic hepatitis , or liver failure , and usually occurs when liver function deteriorates rapidly because of a sudden insult such as an infection , bleeding in the gastrointestinal tract , or overuse of diuretic medications . HRS is a relatively common complication of cirrhosis , occurring in 18 % of people within one year of their diagnosis , and in 39 % within five years of their diagnosis . Deteriorating liver function is believed to cause changes in the circulation that supplies the intestines , altering blood flow and blood vessel tone in the kidneys . The kidney failure of HRS is a consequence of these changes in blood flow , rather than direct damage to the kidney . The diagnosis of hepatorenal syndrome is based on laboratory tests of individuals susceptible to the condition . Two forms of hepatorenal syndrome have been defined : Type 1 HRS entails a rapidly progressive decline in kidney function , while type 2 HRS is associated with ascites ( fluid accumulation in the abdomen ) that does not improve with standard diuretic medications . </P>
<P> HRS can affect individuals with cirrhosis , severe alcoholic hepatitis , or liver failure , and usually occurs when liver function deteriorates rapidly because of a sudden insult such as an infection , bleeding in the gastrointestinal tract , or overuse of diuretic medications . HRS is a relatively common complication of cirrhosis , occurring in 18 % of people within one year of their diagnosis , and in 39 % within five years of their diagnosis . Deteriorating liver function is believed to cause changes in the circulation that supplies the intestines , altering blood flow and blood vessel tone in the kidneys . The kidney failure of HRS is a consequence of these changes in blood flow , rather than direct damage to the kidney . The diagnosis of hepatorenal syndrome is based on laboratory tests of individuals susceptible to the condition . Two forms of hepatorenal syndrome have been defined : Type 1 HRS entails a rapidly progressive decline in kidney function , while type 2 HRS is associated with ascites ( fluid accumulation in the abdomen ) that does not improve with standard diuretic medications . </P>
why does liver failure lead to kidney failure
why does liver failure lead to kidney failure
changes in blood flow , rather than direct damage to the kidney
changes in blood flow , rather than direct damage to the kidney