<P> Reed -- Sternberg cells ( also known as lacunar histiocytes for certain types ) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin 's lymphoma ( a.k.a. Hodgkin 's disease , a type of lymphoma ) . They are usually derived from B lymphocytes , classically considered crippled germinal center B cells , meaning they have not undergone hypermutation to express their antibody . Seen against a sea of B cells , they give the tissue a moth - eaten appearance . </P>
<P> Reed -- Sternberg cells ( also known as lacunar histiocytes for certain types ) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin 's lymphoma ( a.k.a. Hodgkin 's disease , a type of lymphoma ) . They are usually derived from B lymphocytes , classically considered crippled germinal center B cells , meaning they have not undergone hypermutation to express their antibody . Seen against a sea of B cells , they give the tissue a moth - eaten appearance . </P>
reed-sternberg cells in lymphatic tissue is diagnostic of
reed-sternberg cells in lymphatic tissue is diagnostic of
Hodgkin 's lymphoma ( a.k.a. Hodgkin 's disease , a type of lymphoma )
Hodgkin 's lymphoma ( a.k.a. Hodgkin 's disease , a type of lymphoma )