<P> Most cell types take up iron primarily through receptor - mediated endocytosis via transferrin receptor 1 ( TFR1 ) , transferrin receptor 2 ( TFR2 ) and GAPDH . TFR1 has a 30-fold higher affinity for transferrin - bound iron than TFR2 and thus is the main player in this process . The higher order multifunctional glycolytic enzyme glyceraldehyde - 3 - phosphate dehydrogenase ( GAPDH ) also acts as a transferrin receptor . Transferrin - bound ferric iron is recognized by these transferrin receptors , triggering a conformational change that causes endocytosis . Iron then enters the cytoplasm from the endosome via importer DMT1 after being reduced to its ferrous state by a STEAP family reductase . </P>
<P> Most cell types take up iron primarily through receptor - mediated endocytosis via transferrin receptor 1 ( TFR1 ) , transferrin receptor 2 ( TFR2 ) and GAPDH . TFR1 has a 30-fold higher affinity for transferrin - bound iron than TFR2 and thus is the main player in this process . The higher order multifunctional glycolytic enzyme glyceraldehyde - 3 - phosphate dehydrogenase ( GAPDH ) also acts as a transferrin receptor . Transferrin - bound ferric iron is recognized by these transferrin receptors , triggering a conformational change that causes endocytosis . Iron then enters the cytoplasm from the endosome via importer DMT1 after being reduced to its ferrous state by a STEAP family reductase . </P>
where does the iron in your blood come from
where does the iron in your blood come from
receptor - mediated endocytosis
receptor - mediated endocytosis