<P> Fusion proteins or chimeric ( \ kī - ˈmir - ik ) proteins ( literally , made of parts from different sources ) are proteins created through the joining of two or more genes that originally coded for separate proteins . Translation of this fusion gene results in a single or multiple polypeptides with functional properties derived from each of the original proteins . Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics . Chimeric or chimera usually designate hybrid proteins made of polypeptides having different functions or physico - chemical patterns . Chimeric mutant proteins occur naturally when a complex mutation , such as a chromosomal translocation , tandem duplication , or retrotransposition creates a novel coding sequence containing parts of the coding sequences from two different genes . Naturally occurring fusion proteins are commonly found in cancer cells , where they may function as oncoproteins . The bcr - abl fusion protein is a well - known example of an oncogenic fusion protein , and is considered to be the primary oncogenic driver of chronic myelogenous leukemia . </P>
<P> Fusion proteins or chimeric ( \ kī - ˈmir - ik ) proteins ( literally , made of parts from different sources ) are proteins created through the joining of two or more genes that originally coded for separate proteins . Translation of this fusion gene results in a single or multiple polypeptides with functional properties derived from each of the original proteins . Recombinant fusion proteins are created artificially by recombinant DNA technology for use in biological research or therapeutics . Chimeric or chimera usually designate hybrid proteins made of polypeptides having different functions or physico - chemical patterns . Chimeric mutant proteins occur naturally when a complex mutation , such as a chromosomal translocation , tandem duplication , or retrotransposition creates a novel coding sequence containing parts of the coding sequences from two different genes . Naturally occurring fusion proteins are commonly found in cancer cells , where they may function as oncoproteins . The bcr - abl fusion protein is a well - known example of an oncogenic fusion protein , and is considered to be the primary oncogenic driver of chronic myelogenous leukemia . </P>
what type of mutation produces the bcr-abl chimeric protein
what type of mutation produces the bcr-abl chimeric protein
chromosomal translocation tandem duplication retrotransposition
chromosomal translocation tandem duplication retrotransposition