<P> Metabolites are the substances ( generally waste products ) produced as a result of muscular contraction . They include chloride , potassium , lactic acid , ADP , magnesium ( Mg ) , reactive oxygen species , and inorganic phosphate . Accumulation of metabolites can directly or indirectly produce metabolic fatigue within muscle fibers through interference with the release of calcium ( Ca ) from the sarcoplasmic reticulum or reduction of the sensitivity of contractile molecules actin and myosin to calcium . </P>
<P> Metabolites are the substances ( generally waste products ) produced as a result of muscular contraction . They include chloride , potassium , lactic acid , ADP , magnesium ( Mg ) , reactive oxygen species , and inorganic phosphate . Accumulation of metabolites can directly or indirectly produce metabolic fatigue within muscle fibers through interference with the release of calcium ( Ca ) from the sarcoplasmic reticulum or reduction of the sensitivity of contractile molecules actin and myosin to calcium . </P>
muscle fatigue occurs due to a buildup of
muscle fatigue occurs due to a buildup of
metabolites
metabolites