<P> Parietal cells also produce intrinsic factor . Intrinsic factor is required for the absorption of vitamin B in the diet . A long - term deficiency in vitamin B can lead to megaloblastic anemia , characterized by large fragile erythrocytes . Pernicious anaemia results from autoimmune destruction of gastric parietal cells , precluding the synthesis of intrinsic factor and , by extension , absorption of Vitamin B. Pernicious anemia also leads to megaloblastic anemia . Atrophic gastritis , particularly in the elderly , will cause an inability to absorb B and can lead to deficiencies such as decreased DNA synthesis and nucleotide metabolism in the bone marrow . </P>
<P> Parietal cells also produce intrinsic factor . Intrinsic factor is required for the absorption of vitamin B in the diet . A long - term deficiency in vitamin B can lead to megaloblastic anemia , characterized by large fragile erythrocytes . Pernicious anaemia results from autoimmune destruction of gastric parietal cells , precluding the synthesis of intrinsic factor and , by extension , absorption of Vitamin B. Pernicious anemia also leads to megaloblastic anemia . Atrophic gastritis , particularly in the elderly , will cause an inability to absorb B and can lead to deficiencies such as decreased DNA synthesis and nucleotide metabolism in the bone marrow . </P>
what type of cells are primarily responsible for the secretion of intrinsic factor
what type of cells are primarily responsible for the secretion of intrinsic factor
Parietal cells
Parietal cells