<P> The theory states that in a pre-existing group of lymphocytes ( specifically B cells ) , a specific antigen only activates ( i.e. selection ) its counter-specific cell so that particular cell is induced to multiply ( producing its clones ) for antibody production . This activation occurs in secondary lymphoid organs such as the spleen and the lymph nodes . In short the theory is an explanation of the mechanism for the generation of diversity of antibody specificity . The first experimental evidence came in 1958 , when Gustav Nossal and Joshua Lederberg showed that one B cell always produces only one antibody . The idea turned out to be the foundation of molecular immunology , especially in adaptive immunity . </P>
<P> The theory states that in a pre-existing group of lymphocytes ( specifically B cells ) , a specific antigen only activates ( i.e. selection ) its counter-specific cell so that particular cell is induced to multiply ( producing its clones ) for antibody production . This activation occurs in secondary lymphoid organs such as the spleen and the lymph nodes . In short the theory is an explanation of the mechanism for the generation of diversity of antibody specificity . The first experimental evidence came in 1958 , when Gustav Nossal and Joshua Lederberg showed that one B cell always produces only one antibody . The idea turned out to be the foundation of molecular immunology , especially in adaptive immunity . </P>
where does clonal selection of t cells happen
where does clonal selection of t cells happen
in secondary lymphoid organs such as the spleen and the lymph nodes
in secondary lymphoid organs such as the spleen and the lymph nodes