<P> Trypsin is produced as the inactive zymogen trypsinogen in the pancreas . When the pancreas is stimulated by cholecystokinin , it is then secreted into the first part of the small intestine ( the duodenum ) via the pancreatic duct . Once in the small intestine , the enzyme enteropeptidase activates trypsinogen into trypsin by proteolytic cleavage . Autocatalysis does not happen with trypsin , as trypsinogen is a poor substrate , therefore enzymatic damage to the pancreas is avoided . </P>
<P> Trypsin is produced as the inactive zymogen trypsinogen in the pancreas . When the pancreas is stimulated by cholecystokinin , it is then secreted into the first part of the small intestine ( the duodenum ) via the pancreatic duct . Once in the small intestine , the enzyme enteropeptidase activates trypsinogen into trypsin by proteolytic cleavage . Autocatalysis does not happen with trypsin , as trypsinogen is a poor substrate , therefore enzymatic damage to the pancreas is avoided . </P>
where is trypsin found in the digestive system
where is trypsin found in the digestive system
the first part of the small intestine ( the duodenum )
the first part of the small intestine ( the duodenum )