<P> The H receptor is a histamine receptor belonging to the family of rhodopsin - like G - protein - coupled receptors . This receptor is activated by the biogenic amine histamine . It is expressed in smooth muscles , on vascular endothelial cells , in the heart , and in the central nervous system . The H receptor is linked to an intracellular G - protein ( G ) that activates phospholipase C and the inositol triphosphate ( IP3 ) signalling pathway . Antihistamines , which act on this receptor , are used as anti-allergy drugs . The crystal structure of the receptor has been determined ( shown on the right ) and used to discover new histamine H receptor ligands in structure - based virtual screening studies . </P>
<P> The H receptor is a histamine receptor belonging to the family of rhodopsin - like G - protein - coupled receptors . This receptor is activated by the biogenic amine histamine . It is expressed in smooth muscles , on vascular endothelial cells , in the heart , and in the central nervous system . The H receptor is linked to an intracellular G - protein ( G ) that activates phospholipase C and the inositol triphosphate ( IP3 ) signalling pathway . Antihistamines , which act on this receptor , are used as anti-allergy drugs . The crystal structure of the receptor has been determined ( shown on the right ) and used to discover new histamine H receptor ligands in structure - based virtual screening studies . </P>
where are h1 receptors found in the body
where are h1 receptors found in the body
smooth muscles vascular endothelial cells the heart the central nervous system
smooth muscles vascular endothelial cells the heart the central nervous system