<P> In the National Football League ( NFL ) and the American Football League ( AFL ) , 130 different quarterbacks have passed for at least 400 yards in a single game : 309 times in the regular season and 20 more in the postseason . Sid Luckman was the first to pass for 400 yards , in 1943 . Drew Brees has recorded the most 400 - yard games , with 18 in total . Brees has also recorded the most 400 - yard postseason games , with 3 , including 2 consecutive in a single postseason ( unofficial 3 consecutive over two postseasons ) . Cam Newton is the only player to throw for 400 yards in his first career game , and the only rookie with two ( coincidentally consecutive ) 400 yard games . Don Strock is the only quarterback to have thrown for 400 yards in a game that he did not start . Kurt Warner and Tom Brady are the only two quarterbacks to have thrown a 400 - yard game in the Super Bowl , and Brady is the only quarterback to have thrown a 500 - yard game in the Super Bowl . </P>
<P> In the National Football League ( NFL ) and the American Football League ( AFL ) , 130 different quarterbacks have passed for at least 400 yards in a single game : 309 times in the regular season and 20 more in the postseason . Sid Luckman was the first to pass for 400 yards , in 1943 . Drew Brees has recorded the most 400 - yard games , with 18 in total . Brees has also recorded the most 400 - yard postseason games , with 3 , including 2 consecutive in a single postseason ( unofficial 3 consecutive over two postseasons ) . Cam Newton is the only player to throw for 400 yards in his first career game , and the only rookie with two ( coincidentally consecutive ) 400 yard games . Don Strock is the only quarterback to have thrown for 400 yards in a game that he did not start . Kurt Warner and Tom Brady are the only two quarterbacks to have thrown a 400 - yard game in the Super Bowl , and Brady is the only quarterback to have thrown a 500 - yard game in the Super Bowl . </P>
who has the most 400 yard passing games in the nfl
who has the most 400 yard passing games in the nfl
Drew Brees
Drew Brees