[PAR] [TLE] Phoebus Levene [SEP] Phoebus Aaron Theodore Levene, M.D. (25 February 1869 – 6 September 1940) was an American biochemist who studied the structure and function of nucleic acids.  He characterized the different forms of nucleic acid, DNA from RNA, and found that DNA contained adenine, guanine, thymine, cytosine, deoxyribose, and a phosphate group. [PAR] [TLE] Protein phosphorylation [SEP] Protein phosphorylation is a post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group.  Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or modifying its function.  The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by protein phosphatases. Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins.  The amino acids most commonly phosphorylated are serine, threonine, and tyrosine in eukaryotes, and histidine in prokaryotes, which play important and well-characterized roles in signaling pathways and metabolism.  However, many other amino acids can also be phosphorylated, including arginine, lysine, and cysteine.  Protein phosphorylation was first reported in 1906 by Phoebus Levene at the Rockefeller Institute for Medical Research with the discovery of phosphorylated vitellin.  However, it was nearly 50 years until the enzymatic phosphorylation of proteins by protein kinases was discovered.
[PAR] [TLE] Phoebus Levene [ SEP ] Phoebus Aaron Theodore Levene , M.D. ( 25 February 1869 – 6 September 1940 ) was an American biochemist who studied the structure and function of nucleic acids . He characterized the different forms of nucleic acid , DNA from RNA , and found that DNA contained adenine , guanine , thymine , cytosine , deoxyribose , and a phosphate group . [PAR] [TLE] Protein phosphorylation [ SEP ] Protein phosphorylation is a post - translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group . Phosphorylation alters the structural conformation of a protein , causing it to become activated , deactivated , or modifying its function . The reverse reaction of phosphorylation is called dephosphorylation , and is catalyzed by protein phosphatases . Protein kinases and phosphatases work independently and in a balance to regulate the function of proteins . The amino acids most commonly phosphorylated are serine , threonine , and tyrosine in eukaryotes , and histidine in prokaryotes , which play important and well - characterized roles in signaling pathways and metabolism . However , many other amino acids can also be phosphorylated , including arginine , lysine , and cysteine . Protein phosphorylation was first reported in 1906 by Phoebus Levene at the Rockefeller Institute for Medical Research with the discovery of phosphorylated vitellin . However , it was nearly 50 years until the enzymatic phosphorylation of proteins by protein kinases was discovered .
What American biochemist, born February 1869 was first responsible for reporting Protein phosphorylation?
What American biochemist , born February 1869 was first responsible for reporting Protein phosphorylation ?
Phoebus Levene
Phoebus Levene