[PAR] [TLE] Nitric oxide [SEP] Nitric oxide (nitrogen oxide, nitrogen monoxide) is a molecular, chemical compound with chemical formula of ·NO.  One of several oxides of nitrogen, it is a colorless gas under standard conditions.  Nitric oxide is a free radical—i.e., its bonding structure includes an unpaired electron, represented by the dot (·) on the nitrogen atom—and it is in the class of heteronuclear diatomic molecules that are of historic theoretical interest (for the insights they gave in formulating early modern theories of bonding).  It is a particularly important intermediate in the chemical industry.  In addition, nitric oxide is formed in nitrogen-oxygen mixtures at high-temperature conditions, such as those found in combustion systems including internal combustion piston engines, gas turbines, industrial furnaces, and boilers.  It is also produced naturally by the extremely high air temperatures produced along the path of lightning in thunderstorms. [PAR] [TLE] Carbon monoxide-releasing molecules [SEP] Carbon monoxide-releasing molecules (CO-RMs) are chemical compounds that release controlled amounts of carbon monoxide (CO) to cells and tissues and are being developed as potential therapeutic agents.  Although long recognized as a poison, CO also exhibits beneficial effects in small doses.  These effects include anti-inflammatory activity, vasodilatation, and cardioprotection.  CO is produced in mammals during the degradation of heme by heme oxygenase-1, a redox-sensitive enzyme induced by oxidative stress.  It is this enzymatic reaction that inspired the development of synthetic CO-RMs.  Therapeutic drugs have historically been developed based on the similar activity of small molecules in biological signaling, examples exist in the case of both HS and NO-releasing drugs.
[PAR] [TLE] Nitric oxide [ SEP ] Nitric oxide ( nitrogen oxide , nitrogen monoxide ) is a molecular , chemical compound with chemical formula of · NO . One of several oxides of nitrogen , it is a colorless gas under standard conditions . Nitric oxide is a free radical — i.e . , its bonding structure includes an unpaired electron , represented by the dot ( · ) on the nitrogen atom — and it is in the class of heteronuclear diatomic molecules that are of historic theoretical interest ( for the insights they gave in formulating early modern theories of bonding ) . It is a particularly important intermediate in the chemical industry . In addition , nitric oxide is formed in nitrogen - oxygen mixtures at high - temperature conditions , such as those found in combustion systems including internal combustion piston engines , gas turbines , industrial furnaces , and boilers . It is also produced naturally by the extremely high air temperatures produced along the path of lightning in thunderstorms . [PAR] [TLE] Carbon monoxide - releasing molecules [ SEP ] Carbon monoxide - releasing molecules ( CO - RMs ) are chemical compounds that release controlled amounts of carbon monoxide ( CO ) to cells and tissues and are being developed as potential therapeutic agents . Although long recognized as a poison , CO also exhibits beneficial effects in small doses . These effects include anti - inflammatory activity , vasodilatation , and cardioprotection . CO is produced in mammals during the degradation of heme by heme oxygenase-1 , a redox - sensitive enzyme induced by oxidative stress . It is this enzymatic reaction that inspired the development of synthetic CO - RMs . Therapeutic drugs have historically been developed based on the similar activity of small molecules in biological signaling , examples exist in the case of both HS and NO - releasing drugs .
What colorless gas has historically been used to develop therapeutic drugs?
What colorless gas has historically been used to develop therapeutic drugs ?
Nitric oxide
Nitric oxide