In the mid-1950s, Frank Burnet, inspired by a suggestion made by Niels Jerne, formulated the clonal selection theory (CST) of immunity. On the basis of CST, Burnet developed a theory of how an immune response is triggered according to the self/nonself distinction: "self" constituents (constituents of the body) do not trigger destructive immune responses, while "nonself" entities (e.g., pathogens, an allograft) trigger a destructive immune response. The theory was later modified to reflect new discoveries regarding histocompatibility or the complex "two-signal" activation of T cells. The self/nonself theory of immunity and the self/nonself vocabulary have been criticized, but remain very influential.
In the mid-1950s , Frank Burnet , inspired by a suggestion made by Niels Jerne , formulated the clonal selection theory ( CST ) of immunity . On the basis of CST , Burnet developed a theory of how an immune response is triggered according to the self / nonself distinction : " self " constituents ( constituents of the body ) do not trigger destructive immune responses , while " nonself " entities ( e.g. , pathogens , an allograft ) trigger a destructive immune response . The theory was later modified to reflect new discoveries regarding histocompatibility or the complex " two - signal " activation of T cells . The self / nonself theory of immunity and the self / nonself vocabulary have been criticized , but remain very influential .
When was clonal selection theory first proposed?
When was clonal selection theory first proposed ?
In the mid-1950s
In the mid-1950s