Mutations or deletions of clock gene in mice have demonstrated the importance of body clocks to ensure the proper timing of cellular/metabolic events; clock-mutant mice are hyperphagic and obese, and have altered glucose metabolism. In mice, deletion of the Rev-ErbA alpha clock gene facilitates diet-induced obesity and changes the balance between glucose and lipid utilization predisposing to diabetes. However, it is not clear whether there is a strong association between clock gene polymorphisms in humans and the susceptibility to develop the metabolic syndrome.
Mutations or deletions of clock gene in mice have demonstrated the importance of body clocks to ensure the proper timing of cellular / metabolic events ; clock - mutant mice are hyperphagic and obese , and have altered glucose metabolism . In mice , deletion of the Rev - ErbA alpha clock gene facilitates diet - induced obesity and changes the balance between glucose and lipid utilization predisposing to diabetes . However , it is not clear whether there is a strong association between clock gene polymorphisms in humans and the susceptibility to develop the metabolic syndrome .
How certain is it that these circadian clock  effects are the same in humans?
How certain is it that these circadian clock effects are the same in humans ?
not clear
not clear