<P> Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver . Normally , metabolism of cocaine produces two primarily biologically inactive metabolites -- benzoylecgonine and ecgonine methyl ester . The hepatic enzyme carboxylesterase is an important part of cocaine 's metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver , which produces these inactive metabolites . If ethanol is present during the metabolism of cocaine , a portion of the cocaine undergoes transesterification with ethanol , rather than undergoing hydrolysis with water , which results in the production of cocaethylene . </P>
<P> Cocaethylene is the byproduct of concurrent consumption of alcohol and cocaine as metabolized by the liver . Normally , metabolism of cocaine produces two primarily biologically inactive metabolites -- benzoylecgonine and ecgonine methyl ester . The hepatic enzyme carboxylesterase is an important part of cocaine 's metabolism because it acts as a catalyst for the hydrolysis of cocaine in the liver , which produces these inactive metabolites . If ethanol is present during the metabolism of cocaine , a portion of the cocaine undergoes transesterification with ethanol , rather than undergoing hydrolysis with water , which results in the production of cocaethylene . </P>
cocaethylene is produced as an active metabolite of
cocaethylene is produced as an active metabolite of
cocaine
cocaine