<P> Inborn errors of metabolism form a large class of genetic diseases involving congenital disorders of metabolism . The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances ( substrates ) into others ( products ) . In most of the disorders , problems arise due to accumulation of substances which are toxic or interfere with normal function , or to the effects of reduced ability to synthesize essential compounds . Inborn errors of metabolism are now often referred to as congenital metabolic diseases or inherited metabolic disorders . The term inborn errors of metabolism was coined by a British physician , Archibald Garrod ( 1857 -- 1936 ) , in 1908 . He is known for work that prefigured the `` one gene - one enzyme '' hypothesis , based on his studies on the nature and inheritance of alkaptonuria . His seminal text , Inborn Errors of Metabolism was published in 1923 . </P>
<P> Inborn errors of metabolism form a large class of genetic diseases involving congenital disorders of metabolism . The majority are due to defects of single genes that code for enzymes that facilitate conversion of various substances ( substrates ) into others ( products ) . In most of the disorders , problems arise due to accumulation of substances which are toxic or interfere with normal function , or to the effects of reduced ability to synthesize essential compounds . Inborn errors of metabolism are now often referred to as congenital metabolic diseases or inherited metabolic disorders . The term inborn errors of metabolism was coined by a British physician , Archibald Garrod ( 1857 -- 1936 ) , in 1908 . He is known for work that prefigured the `` one gene - one enzyme '' hypothesis , based on his studies on the nature and inheritance of alkaptonuria . His seminal text , Inborn Errors of Metabolism was published in 1923 . </P>
who wrote the book inborn errors of metabolism
who wrote the book inborn errors of metabolism
British physician , Archibald Garrod
British physician , Archibald Garrod