<P> The total body clearance will be equal to the renal clearance + hepatic clearance + lung clearance . Although for many drugs the clearance is simply considered as the renal excretion ability , that is , the rate at which waste substances are cleared from the blood by the kidney . In these cases clearance is almost synonymous with renal clearance or renal plasma clearance . Each substance has a specific clearance that depends on its filtration characteristics . Clearance is a function of glomerular filtration , secretion from the peritubular capillaries to the nephron , and re-absorption from the nephron back to the peritubular capillaries . Clearance is variable in zero - order kinetics because a constant amount of the drug is eliminated per unit time , but it is constant in first - order kinetics , because the amount of drug eliminated per unit time changes with the concentration of drug in the blood . The concept of clearance was described by Thomas Addis , a graduate of the University of Edinburgh Medical School . </P>
<P> The total body clearance will be equal to the renal clearance + hepatic clearance + lung clearance . Although for many drugs the clearance is simply considered as the renal excretion ability , that is , the rate at which waste substances are cleared from the blood by the kidney . In these cases clearance is almost synonymous with renal clearance or renal plasma clearance . Each substance has a specific clearance that depends on its filtration characteristics . Clearance is a function of glomerular filtration , secretion from the peritubular capillaries to the nephron , and re-absorption from the nephron back to the peritubular capillaries . Clearance is variable in zero - order kinetics because a constant amount of the drug is eliminated per unit time , but it is constant in first - order kinetics , because the amount of drug eliminated per unit time changes with the concentration of drug in the blood . The concept of clearance was described by Thomas Addis , a graduate of the University of Edinburgh Medical School . </P>
how to calculate the clearance of a drug
how to calculate the clearance of a drug
equal to the renal clearance + hepatic clearance + lung clearance
equal to the renal clearance + hepatic clearance + lung clearance