<P> The first hepatitis B vaccine was approved in the United States in 1981 . A recombinant version came to market in 1986 . It is on the World Health Organization 's List of Essential Medicines , the most effective and safe medicines needed in a health system . As of 2014 , the wholesale cost in the developing world is US $ 0.58 -- 13.20 per dose . In the United States it costs US $50 -- 100 . </P>
<P> The first hepatitis B vaccine was approved in the United States in 1981 . A recombinant version came to market in 1986 . It is on the World Health Organization 's List of Essential Medicines , the most effective and safe medicines needed in a health system . As of 2014 , the wholesale cost in the developing world is US $ 0.58 -- 13.20 per dose . In the United States it costs US $50 -- 100 . </P>
when did the hepatitis b vaccine come out
when did the hepatitis b vaccine come out
1981
1981