<P> Primase adds RNA primers onto the lagging strand , which allows synthesis of Okazaki fragments from 5 ' to 3 ' . However , primase creates RNA primers at a much lower rate than that at which DNA polymerase synthesizes DNA on the leading strand . DNA polymerase on the lagging strand also has to be continually recycled to construct Okazaki fragments following RNA primers . This makes the speed of lagging strand synthesis much lower than that of the leading strand . To solve this , primase acts as a temporary stop signal , briefly halting the progression of the replication fork during DNA replication . This molecular process prevents the leading strand from overtaking the lagging strand . </P>
<P> Primase adds RNA primers onto the lagging strand , which allows synthesis of Okazaki fragments from 5 ' to 3 ' . However , primase creates RNA primers at a much lower rate than that at which DNA polymerase synthesizes DNA on the leading strand . DNA polymerase on the lagging strand also has to be continually recycled to construct Okazaki fragments following RNA primers . This makes the speed of lagging strand synthesis much lower than that of the leading strand . To solve this , primase acts as a temporary stop signal , briefly halting the progression of the replication fork during DNA replication . This molecular process prevents the leading strand from overtaking the lagging strand . </P>
which enzyme seals okazaki fragments on the lagging strand
which enzyme seals okazaki fragments on the lagging strand
Primase
Primase