<P> Most of the supervillains of Spider - Man would be introduced in The Amazing Spider - Man comic book starting with the Chameleon . The early villains would be introduced in the 1960s in the Silver Age of Comic Books . Originally created by Stan Lee and Steve Ditko . John Romita , Sr. would soon replace Ditko starting with the Rhino . Gerry Conway later replaced Stan Lee and helped create new adversaries for the web - slinger and also helped pave the way to the Bronze Age of Comic Books with depicting Green Goblin as the killer of Spider - Man 's long time romantic interest , Gwen Stacy . Many collaborators would soon take over The Amazing Spider - Man title . One of the more popular examples included Todd McFarlane 's Venom in the Modern Age of Comic Books . Note : Alter ego characters who are the most high profile in the supervillain alias but others have shared that supervillain name are in bold . Alter egos listed having N / A use their real name as the supervillain name . In chronological order . </P>
<P> Most of the supervillains of Spider - Man would be introduced in The Amazing Spider - Man comic book starting with the Chameleon . The early villains would be introduced in the 1960s in the Silver Age of Comic Books . Originally created by Stan Lee and Steve Ditko . John Romita , Sr. would soon replace Ditko starting with the Rhino . Gerry Conway later replaced Stan Lee and helped create new adversaries for the web - slinger and also helped pave the way to the Bronze Age of Comic Books with depicting Green Goblin as the killer of Spider - Man 's long time romantic interest , Gwen Stacy . Many collaborators would soon take over The Amazing Spider - Man title . One of the more popular examples included Todd McFarlane 's Venom in the Modern Age of Comic Books . Note : Alter ego characters who are the most high profile in the supervillain alias but others have shared that supervillain name are in bold . Alter egos listed having N / A use their real name as the supervillain name . In chronological order . </P>
who was the first super villain spiderman ever encountered
who was the first super villain spiderman ever encountered
the Chameleon
the Chameleon