<P> In molecular biology , the iron response element or iron - responsive element ( IRE ) is a short conserved stem - loop which is bound by iron response proteins ( IRPs , also named IRE - BP or IRBP ) . The IRE is found in UTRs ( untranslated regions ) of various mRNAs whose products are involved in iron metabolism . For example , the mRNA of ferritin ( an iron storage protein ) contains one IRE in its 5 ' UTR . When iron concentration is low , IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates . In contrast , binding to multiple IREs in the 3 ' UTR of the transferrin receptor ( involved in iron acquisition ) leads to increased mRNA stability . </P>
<P> In molecular biology , the iron response element or iron - responsive element ( IRE ) is a short conserved stem - loop which is bound by iron response proteins ( IRPs , also named IRE - BP or IRBP ) . The IRE is found in UTRs ( untranslated regions ) of various mRNAs whose products are involved in iron metabolism . For example , the mRNA of ferritin ( an iron storage protein ) contains one IRE in its 5 ' UTR . When iron concentration is low , IRPs bind the IRE in the ferritin mRNA and cause reduced translation rates . In contrast , binding to multiple IREs in the 3 ' UTR of the transferrin receptor ( involved in iron acquisition ) leads to increased mRNA stability . </P>
where is the ire located in the ferritin gene
where is the ire located in the ferritin gene
UTRs ( untranslated regions ) of various mRNAs whose products are involved in iron metabolism
UTRs ( untranslated regions ) of various mRNAs whose products are involved in iron metabolism