<P> Intracerebroventricular injection ( ICVI ) is an invasive injection technique of substances directly into the cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier . Although this barrier effectively protects the brain , it can prevent important medications to enter the CNS . The technique is widely used in biomedical research to introduce drugs , therapeutic RNAs , plasmid DNAs , and viral vectors into the CNS of diseased mice models . It can also be used in human in cases of neurodegenerative disorders like spinal muscular atrophy ( SMA ) , or administering chemotherapy in gliomas as well as delivering neurotrophic factors to CNS . </P>
<P> Intracerebroventricular injection ( ICVI ) is an invasive injection technique of substances directly into the cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier . Although this barrier effectively protects the brain , it can prevent important medications to enter the CNS . The technique is widely used in biomedical research to introduce drugs , therapeutic RNAs , plasmid DNAs , and viral vectors into the CNS of diseased mice models . It can also be used in human in cases of neurodegenerative disorders like spinal muscular atrophy ( SMA ) , or administering chemotherapy in gliomas as well as delivering neurotrophic factors to CNS . </P>
icv ( intracerebroventricular ) injection of a drug involves injections into the
icv ( intracerebroventricular ) injection of a drug involves injections into the
cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier
cerebrospinal fluid in cerebral ventricles in order to bypass the blood brain barrier