<P> The nucleic acid to be separated can be prepared in several ways before separation by electrophoresis . In the case of large DNA molecules , the DNA is frequently cut into smaller fragments using a DNA restriction endonuclease ( or restriction enzyme ) . In other instances , such as PCR amplified samples , enzymes present in the sample that might affect the separation of the molecules are removed through various means before analysis . Once the nucleic acid is properly prepared , the samples of the nucleic acid solution are placed in the wells of the gel and a voltage is applied across the gel for a specified amount of time . </P>
<P> The nucleic acid to be separated can be prepared in several ways before separation by electrophoresis . In the case of large DNA molecules , the DNA is frequently cut into smaller fragments using a DNA restriction endonuclease ( or restriction enzyme ) . In other instances , such as PCR amplified samples , enzymes present in the sample that might affect the separation of the molecules are removed through various means before analysis . Once the nucleic acid is properly prepared , the samples of the nucleic acid solution are placed in the wells of the gel and a voltage is applied across the gel for a specified amount of time . </P>
where are the dna samples inserted into the gel
where are the dna samples inserted into the gel
in the wells of the gel
in the wells of the gel