<P> Izzie supports Alex when he discovers his new girlfriend has psychiatric problems , and convinces him to have her committed . She is also handed primary responsibility for the clinic , as Bailey cuts back on her responsibilities . Izzie and Alex go on to rekindle their relationship , though Izzie is concerned when she begins hallucinating Denny . She discovers she has metastatic melanoma ( Stage IV ) which has spread to her liver , skin , and brain , causing the hallucinations . Her survival chances are estimated at only 5 % . She is admitted to Seattle Grace as a patient , and Derek Shepherd ( Patrick Dempsey ) successfully removes a tumor from her brain . Izzie spends her time in the hospital planning Meredith and Derek 's wedding , but when her condition worsens and Derek discovers a second brain tumor , they give the ceremony to Izzie and Alex , who marry in front of all their friends . The procedure to remove the second tumor from Izzie 's brain causes her to lose her short - term memory , and although she soon regains it , she flatlines moments later . The fifth season ends with her friends ignoring her DNR order and attempting to resuscitate her , transposed with images of Izzie in an elevator encountering George , who has been in an accident and is also currently flatlining . Though George dies , Izzie is resuscitated and recovers enough to return to work . </P>
<P> Izzie supports Alex when he discovers his new girlfriend has psychiatric problems , and convinces him to have her committed . She is also handed primary responsibility for the clinic , as Bailey cuts back on her responsibilities . Izzie and Alex go on to rekindle their relationship , though Izzie is concerned when she begins hallucinating Denny . She discovers she has metastatic melanoma ( Stage IV ) which has spread to her liver , skin , and brain , causing the hallucinations . Her survival chances are estimated at only 5 % . She is admitted to Seattle Grace as a patient , and Derek Shepherd ( Patrick Dempsey ) successfully removes a tumor from her brain . Izzie spends her time in the hospital planning Meredith and Derek 's wedding , but when her condition worsens and Derek discovers a second brain tumor , they give the ceremony to Izzie and Alex , who marry in front of all their friends . The procedure to remove the second tumor from Izzie 's brain causes her to lose her short - term memory , and although she soon regains it , she flatlines moments later . The fifth season ends with her friends ignoring her DNR order and attempting to resuscitate her , transposed with images of Izzie in an elevator encountering George , who has been in an accident and is also currently flatlining . Though George dies , Izzie is resuscitated and recovers enough to return to work . </P>
what season does izzie die on grey 's anatomy
what season does izzie die on grey 's anatomy
The fifth season
The fifth season