<P> The Brain ( voiced by Maurice LaMarche ) looks and sounds a little like Orson Welles . In `` What Ever Happened to Baby Brain '' , Brain actually crosses paths with Welles ( voiced by Jim Cummings ) , who is working as a busboy in a Hollywood restaurant ; they find themselves inadvertently yelling in unison , `` Things will be different when I take over the world ! '' In `` Project B.R.A.I.N. '' Brain 's name is the backronym for the eponymous project : `` Biological Recombinant Algorithmic Intelligence Nexus '' . His tail is curly and bent -- he often uses it to pick the lock of the cage -- and his head is large and wide , housing his abnormally large brain . He is highly intelligent and develops complex plans for global domination using politics , cultural references , and his own inventions toward his goal . He seems coldly unemotional , speaking in a snarky deadpan . Nevertheless , Brain has a subtle sense of humor and has even fallen in love ; with Trudie in the episode `` The Third Mouse '' and with Billie in `` The World Can Wait '' . Due to his stature and megalomania , Brain has been compared to Don Quixote and a pop culture depiction of Napoleon Bonaparte . </P>
<P> The Brain ( voiced by Maurice LaMarche ) looks and sounds a little like Orson Welles . In `` What Ever Happened to Baby Brain '' , Brain actually crosses paths with Welles ( voiced by Jim Cummings ) , who is working as a busboy in a Hollywood restaurant ; they find themselves inadvertently yelling in unison , `` Things will be different when I take over the world ! '' In `` Project B.R.A.I.N. '' Brain 's name is the backronym for the eponymous project : `` Biological Recombinant Algorithmic Intelligence Nexus '' . His tail is curly and bent -- he often uses it to pick the lock of the cage -- and his head is large and wide , housing his abnormally large brain . He is highly intelligent and develops complex plans for global domination using politics , cultural references , and his own inventions toward his goal . He seems coldly unemotional , speaking in a snarky deadpan . Nevertheless , Brain has a subtle sense of humor and has even fallen in love ; with Trudie in the episode `` The Third Mouse '' and with Billie in `` The World Can Wait '' . Due to his stature and megalomania , Brain has been compared to Don Quixote and a pop culture depiction of Napoleon Bonaparte . </P>
who plays brain in pinky and the brain
who plays brain in pinky and the brain
Maurice LaMarche
Maurice LaMarche