<P> The microscope was still largely a novelty until the 1660s and 1670s when naturalists in Italy , the Netherlands and England began using them to study biology , both organisms and their ultrastructure . Italian scientist Marcello Malpighi , called the father of histology by some historians of biology , began his analysis of biological structures with the lungs . Robert Hooke 's Micrographia had a huge impact , largely because of its impressive illustrations . A significant contribution came from Antonie van Leeuwenhoek who achieved up to 300 times magnification using a simple single lens microscope . He sandwiched a very small glass ball lens between the holes in two metal plates riveted together , and with an adjustable - by - screws needle attached to mount the specimen . Then , Van Leeuwenhoek re-discovered red blood cells ( after Jan Swammerdam ) and spermatozoa , and helped popularise the use of microscopes to view biological ultrastructure . On 9 October 1676 , van Leeuwenhoek reported the discovery of micro-organisms . </P>
<P> The microscope was still largely a novelty until the 1660s and 1670s when naturalists in Italy , the Netherlands and England began using them to study biology , both organisms and their ultrastructure . Italian scientist Marcello Malpighi , called the father of histology by some historians of biology , began his analysis of biological structures with the lungs . Robert Hooke 's Micrographia had a huge impact , largely because of its impressive illustrations . A significant contribution came from Antonie van Leeuwenhoek who achieved up to 300 times magnification using a simple single lens microscope . He sandwiched a very small glass ball lens between the holes in two metal plates riveted together , and with an adjustable - by - screws needle attached to mount the specimen . Then , Van Leeuwenhoek re-discovered red blood cells ( after Jan Swammerdam ) and spermatozoa , and helped popularise the use of microscopes to view biological ultrastructure . On 9 October 1676 , van Leeuwenhoek reported the discovery of micro-organisms . </P>
who is credited with producing the strongest early microscope
who is credited with producing the strongest early microscope
Antonie van Leeuwenhoek
Antonie van Leeuwenhoek