<P> Tay -- Sachs disease is caused by a genetic mutation in the HEXA genes on chromosome 15 . It is inherited from a person 's parents in an autosomal recessive manner . The mutation results in problems with an enzyme called beta - hexosamidase A which results in the buildup of the molecule GM2 ganglioside within cells , leading to toxicity . Diagnosis is by measuring the blood hexosaminidase A level or genetic testing . It is a type of sphingolipidoses . </P>
<P> Tay -- Sachs disease is caused by a genetic mutation in the HEXA genes on chromosome 15 . It is inherited from a person 's parents in an autosomal recessive manner . The mutation results in problems with an enzyme called beta - hexosamidase A which results in the buildup of the molecule GM2 ganglioside within cells , leading to toxicity . Diagnosis is by measuring the blood hexosaminidase A level or genetic testing . It is a type of sphingolipidoses . </P>
what type of protein is affected in cells of individuals with tay-sachs
what type of protein is affected in cells of individuals with tay-sachs
beta - hexosamidase A
beta - hexosamidase A