<P> Apolipoprotein E ( ApoE ) is a class of apolipoprotein found in the chylomicron and Intermediate - density lipoprotein ( IDLs ) that is essential for the normal catabolism of triglyceride - rich lipoprotein constituents . In peripheral tissues , ApoE is primarily produced by the liver and macrophages , and mediates cholesterol metabolism in an isoform - dependent manner . In the central nervous system , ApoE is mainly produced by astrocytes , and transports cholesterol to neurons via ApoE receptors , which are members of the low density lipoprotein receptor gene family . ApoE is the principal cholesterol carrier in the brain . This protein is involved in Alzheimer 's disease and cardiovascular disease . </P>
<P> Apolipoprotein E ( ApoE ) is a class of apolipoprotein found in the chylomicron and Intermediate - density lipoprotein ( IDLs ) that is essential for the normal catabolism of triglyceride - rich lipoprotein constituents . In peripheral tissues , ApoE is primarily produced by the liver and macrophages , and mediates cholesterol metabolism in an isoform - dependent manner . In the central nervous system , ApoE is mainly produced by astrocytes , and transports cholesterol to neurons via ApoE receptors , which are members of the low density lipoprotein receptor gene family . ApoE is the principal cholesterol carrier in the brain . This protein is involved in Alzheimer 's disease and cardiovascular disease . </P>
apolipoprotein e4 appears to play a role in
apolipoprotein e4 appears to play a role in
Alzheimer 's disease cardiovascular disease
Alzheimer 's disease cardiovascular disease