<P> MLB 's first regular - season interleague game took place on June 12 , 1997 , as the Texas Rangers hosted the San Francisco Giants at The Ballpark in Arlington . There were four interleague games on the schedule that night , but the other three were played on the West Coast , so the Giants -- Rangers matchup started a few hours earlier than the others . Texas 's Darren Oliver threw the game 's first pitch and San Francisco outfielder Glenallen Hill was the first designated hitter used in a regular - season game by a National League team . San Francisco 's Darryl Hamilton got the first base hit in interleague play , while Stan Javier hit the first home run , leading the Giants to a 4 -- 3 victory over the Rangers . </P>
<P> MLB 's first regular - season interleague game took place on June 12 , 1997 , as the Texas Rangers hosted the San Francisco Giants at The Ballpark in Arlington . There were four interleague games on the schedule that night , but the other three were played on the West Coast , so the Giants -- Rangers matchup started a few hours earlier than the others . Texas 's Darren Oliver threw the game 's first pitch and San Francisco outfielder Glenallen Hill was the first designated hitter used in a regular - season game by a National League team . San Francisco 's Darryl Hamilton got the first base hit in interleague play , while Stan Javier hit the first home run , leading the Giants to a 4 -- 3 victory over the Rangers . </P>
who hit the first mlb interleague home run in 1997
who hit the first mlb interleague home run in 1997
Stan Javier
Stan Javier