<P> Heigl garnered critical acclaim for her performance as Izzie and received numerous awards and nominations for her role , winning the `` Outstanding Supporting Actress In A Drama Series '' at the 2007 Emmy Awards . She was critical of the character 's development during the show 's fourth season , particularly her romance with George . She declined to put herself forward for the 2008 Emmy Awards , citing insufficient material in the role . After speculation that Izzie would be killed off in the fifth season , the character was diagnosed with Stage 4 metastatic melanoma . She married Alex in the series ' one - hundredth episode , and afterwards , her tumor was successfully removed . Izzie made her final appearance in the sixth season , leaving Seattle after Alex refused to resume their marriage . Heigl requested to be released from her contract 18 months early , in order to spend more time with her family . In January 2012 , Heigl reported that she would like to return to Grey 's Anatomy to give closure to her character , however , Rhimes confirmed that there were no plans to have the character return at that time and has since stated that she has no plans to ever re-approach Izzie 's storyline again . </P>
<P> Heigl garnered critical acclaim for her performance as Izzie and received numerous awards and nominations for her role , winning the `` Outstanding Supporting Actress In A Drama Series '' at the 2007 Emmy Awards . She was critical of the character 's development during the show 's fourth season , particularly her romance with George . She declined to put herself forward for the 2008 Emmy Awards , citing insufficient material in the role . After speculation that Izzie would be killed off in the fifth season , the character was diagnosed with Stage 4 metastatic melanoma . She married Alex in the series ' one - hundredth episode , and afterwards , her tumor was successfully removed . Izzie made her final appearance in the sixth season , leaving Seattle after Alex refused to resume their marriage . Heigl requested to be released from her contract 18 months early , in order to spend more time with her family . In January 2012 , Heigl reported that she would like to return to Grey 's Anatomy to give closure to her character , however , Rhimes confirmed that there were no plans to have the character return at that time and has since stated that she has no plans to ever re-approach Izzie 's storyline again . </P>
when does izzy get cancer in greys anatomy
when does izzy get cancer in greys anatomy
fifth season
fifth season