<P> PLP acts as a coenzyme in all transamination reactions , and in certain decarboxylation , deamination , and racemization reactions of amino acids . The aldehyde group of PLP forms a Schiff - base linkage ( internal aldimine ) with the ε - amino group of a specific lysine group of the aminotransferase enzyme . The α - amino group of the amino acid substrate displaces the ε - amino group of the active - site lysine residue in a process known as transaldimination . The resulting external aldimine can lose a proton , carbon dioxide , or an amino acid sidechain to become a quinoid intermediate , which in turn can act as a nucleophile in several reaction pathways . </P>
<P> PLP acts as a coenzyme in all transamination reactions , and in certain decarboxylation , deamination , and racemization reactions of amino acids . The aldehyde group of PLP forms a Schiff - base linkage ( internal aldimine ) with the ε - amino group of a specific lysine group of the aminotransferase enzyme . The α - amino group of the amino acid substrate displaces the ε - amino group of the active - site lysine residue in a process known as transaldimination . The resulting external aldimine can lose a proton , carbon dioxide , or an amino acid sidechain to become a quinoid intermediate , which in turn can act as a nucleophile in several reaction pathways . </P>
where is vitamin b6 activated to form its active form pyridoxal phosphate ( plp )
where is vitamin b6 activated to form its active form pyridoxal phosphate ( plp )
the ε - amino group of a specific lysine group of the aminotransferase enzyme
the ε - amino group of a specific lysine group of the aminotransferase enzyme