<P> A group of drugs called the phenothiazines , including antipsychotics such as chlorpromazine , has been found to antagonize dopamine binding ( particularly at receptors known as D dopamine receptors ) and reduce positive psychotic symptoms . This observation was subsequently extended to other antipsychotic drug classes , such as butyrophenones including haloperidol . The link was strengthened by experiments in the 1970s which suggested that the binding affinity of antipsychotic drugs for D dopamine receptors seemed to be inversely proportional to their therapeutic dose . This correlation , suggesting that receptor binding is causally related to therapeutic potency , was reported by two laboratories in 1976 . </P>
<P> A group of drugs called the phenothiazines , including antipsychotics such as chlorpromazine , has been found to antagonize dopamine binding ( particularly at receptors known as D dopamine receptors ) and reduce positive psychotic symptoms . This observation was subsequently extended to other antipsychotic drug classes , such as butyrophenones including haloperidol . The link was strengthened by experiments in the 1970s which suggested that the binding affinity of antipsychotic drugs for D dopamine receptors seemed to be inversely proportional to their therapeutic dose . This correlation , suggesting that receptor binding is causally related to therapeutic potency , was reported by two laboratories in 1976 . </P>
what schizophrenic symptoms are decreased by drugs that selectively block the d2 dopamine receptor
what schizophrenic symptoms are decreased by drugs that selectively block the d2 dopamine receptor
psychotic
psychotic