<P> The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes . These are the cells responsible for the resorption of bone . Osteoclasts are generally present on the outer layer of bone , just beneath the periosteum . Attachment of the osteoclast to the osteon begins the process . The osteoclast then induces an infolding of its cell membrane and secretes collagenase and other enzymes important in the resorption process . High levels of calcium , magnesium , phosphate and products of collagen will be released into the extracellular fluid as the osteoclasts tunnel into the mineralized bone . Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatological disorders . </P>
<P> The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes . These are the cells responsible for the resorption of bone . Osteoclasts are generally present on the outer layer of bone , just beneath the periosteum . Attachment of the osteoclast to the osteon begins the process . The osteoclast then induces an infolding of its cell membrane and secretes collagenase and other enzymes important in the resorption process . High levels of calcium , magnesium , phosphate and products of collagen will be released into the extracellular fluid as the osteoclasts tunnel into the mineralized bone . Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatological disorders . </P>
are large cells that can cause the breakdown of bone tissue
are large cells that can cause the breakdown of bone tissue
osteoclasts
osteoclasts