<P> Transition state analogs ( transition state analogues ) , are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme - catalyzed chemical reaction . Enzymes interact with a substrate by means of strain or distortions , moving the substrate towards the transition state . Transition state analogs can be used as inhibitors in enzyme - catalyzed reactions by blocking the active site of the enzyme . Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate . Examples of drugs that are transition state analog inhibitors include flu medications such as the neuraminidase inhibitor oseltamivir and the HIV protease inhibitors saquinavir in the treatment of AIDS . </P>
<P> Transition state analogs ( transition state analogues ) , are chemical compounds with a chemical structure that resembles the transition state of a substrate molecule in an enzyme - catalyzed chemical reaction . Enzymes interact with a substrate by means of strain or distortions , moving the substrate towards the transition state . Transition state analogs can be used as inhibitors in enzyme - catalyzed reactions by blocking the active site of the enzyme . Theory suggests that enzyme inhibitors which resembled the transition state structure would bind more tightly to the enzyme than the actual substrate . Examples of drugs that are transition state analog inhibitors include flu medications such as the neuraminidase inhibitor oseltamivir and the HIV protease inhibitors saquinavir in the treatment of AIDS . </P>
compound designed to mimic the structure of a transition state
compound designed to mimic the structure of a transition state
Transition state analogs ( transition state analogues )
Transition state analogs ( transition state analogues )