<P> The endoplasmic reticulum serves many general functions , including the folding of protein molecules in sacs called cisternae and the transport of synthesized proteins in vesicles to the Golgi apparatus . Correct folding of newly made proteins is made possible by several endoplasmic reticulum chaperone proteins , including protein disulfide isomerase ( PDI ) , ERp29 , the Hsp70 family member BiP / Grp78 , calnexin , calreticulin , and the peptidylpropyl isomerase family . Only properly folded proteins are transported from the rough ER to the Golgi apparatus -- unfolded proteins cause an unfolded protein response as a stress response in the ER . Disturbances in redox regulation , calcium regulation , glucose deprivation , and viral infection or the over-expression of proteins can lead to endoplasmic reticulum stress response ( ER stress ) , a state in which the folding of proteins slows , leading to an increase in unfolded proteins . This stress is emerging as a potential cause of damage in hypoxia / ischemia , insulin resistance , and other disorders . </P>
<P> The endoplasmic reticulum serves many general functions , including the folding of protein molecules in sacs called cisternae and the transport of synthesized proteins in vesicles to the Golgi apparatus . Correct folding of newly made proteins is made possible by several endoplasmic reticulum chaperone proteins , including protein disulfide isomerase ( PDI ) , ERp29 , the Hsp70 family member BiP / Grp78 , calnexin , calreticulin , and the peptidylpropyl isomerase family . Only properly folded proteins are transported from the rough ER to the Golgi apparatus -- unfolded proteins cause an unfolded protein response as a stress response in the ER . Disturbances in redox regulation , calcium regulation , glucose deprivation , and viral infection or the over-expression of proteins can lead to endoplasmic reticulum stress response ( ER stress ) , a state in which the folding of proteins slows , leading to an increase in unfolded proteins . This stress is emerging as a potential cause of damage in hypoxia / ischemia , insulin resistance , and other disorders . </P>
what is the primary function of the endoplasmic reticulum
what is the primary function of the endoplasmic reticulum
transport of synthesized proteins
transport of synthesized proteins