def test_layers_view():
    X = np.array([[1, 2, 3], [4, 5, 6], [7, 8, 9]])
    L = np.array([[10, 11, 12], [13, 14, 15], [16, 17, 18]])
    real_adata = ad.AnnData(X)
    real_adata.layers["L"] = L
    view_adata = real_adata[1:, 1:]
    real_hash = joblib.hash(real_adata)
    view_hash = joblib.hash(view_adata)

    assert view_adata.is_view

    with pytest.raises(ValueError):
        view_adata.layers["L2"] = L + 2

    assert view_adata.is_view  # Failing to set layer item makes adata not view
    assert real_hash == joblib.hash(real_adata)
    assert view_hash == joblib.hash(view_adata)

    view_adata.layers["L2"] = L[1:, 1:] + 2

    assert not view_adata.is_view
    assert real_hash == joblib.hash(real_adata)
    assert view_hash != joblib.hash(view_adata)
def compute_svm_score_nestedCV(K, y, n_folds,
                               scoring=balanced_accuracy_scoring,
                               random_state=None,
                               param_grid=[{'C': np.logspace(-5, 5, 25)}]):
    """Compute cross-validated score of SVM using precomputed kernel.
    """
    cv = StratifiedKFold(y, n_folds=n_folds, shuffle=True,
                         random_state=random_state)
    scores = np.zeros(n_folds)
    for i, (train, test) in enumerate(cv):
        cvclf = SVC(kernel='precomputed')
        y_train = y[train]
        cvcv = StratifiedKFold(y_train, n_folds=n_folds,
                               shuffle=True,
                               random_state=random_state)
        clf = GridSearchCV(cvclf, param_grid=param_grid, scoring=scoring,
                           cv=cvcv, n_jobs=1)
        clf.fit(K[train, :][:, train], y_train)
        # print clf.best_params_
        scores[i] = clf.score(K[test, :][:, train], y[test])

    return scores.mean()