def test_drop_obs_column():
    adata = ad.AnnData(np.array(X_list), obs=obs_dict, dtype="int32")

    subset = adata[:2]
    assert subset.is_view
    # returns a copy of obs
    assert subset.obs.drop(columns=["oanno1"]).columns.tolist() == ["oanno2", "oanno3"]
    assert subset.is_view
    # would modify obs, so it should actualize subset and not modify adata
    subset.obs.drop(columns=["oanno1"], inplace=True)
    assert not subset.is_view
    assert subset.obs.columns.tolist() == ["oanno2", "oanno3"]

    assert adata.obs.columns.tolist() == ["oanno1", "oanno2", "oanno3"]
def add_handles(self, model, forward_handle, backward_handle):
        """
        Add handles to all non-container layers in the model.
        Recursively for non-container layers
        """
        handles_list = []
        model_children = list(model.children())
        if model_children:
            for child in model_children:
                handles_list.extend(self.add_handles(child, forward_handle, backward_handle))
        else:  # leaves
            handles_list.append(model.register_forward_hook(forward_handle))
            handles_list.append(model.register_backward_hook(backward_handle))
        return handles_list