def adata():
    adata = ad.AnnData(np.zeros((100, 100)))
    adata.obsm["o"] = np.zeros((100, 50))
    adata.varm["o"] = np.zeros((100, 50))
    return adata
def set_submodule(self, submodule: 'Submodule') -> None:
        """Set this instance's submodule. It must be called before
        the first write operation begins"""
        self._smref = weakref.ref(submodule)