def adata():
    adata = ad.AnnData(np.zeros((100, 100)))
    adata.obsm["o"] = np.zeros((100, 50))
    adata.varm["o"] = np.zeros((100, 50))
    return adata
def _update_changed_options(self):
        changed = {}
        for key in Parameters.updatables:
            if getattr(self.want, key) is not None:
                attr1 = getattr(self.want, key)
                attr2 = getattr(self.have, key)
                if attr1 != attr2:
                    changed[key] = attr1
        if changed:
            self.changes = Parameters(changed)
            return True
        return False