def test_modify_uns_in_copy():
    # https://github.com/theislab/anndata/issues/571
    adata = ad.AnnData(np.ones((5, 5)), uns={"parent": {"key": "value"}})
    adata_copy = adata[:3].copy()
    adata_copy.uns["parent"]["key"] = "new_value"
    assert adata.uns["parent"]["key"] != adata_copy.uns["parent"]["key"]
def compute_rbf_kernel_matrix(X):
    """Compute the RBF kernel matrix with sigma2 as the median pairwise
    distance.
    """
    sigma2 = np.median(pairwise_distances(X, metric='euclidean'))**2
    K = pairwise_kernels(X, X, metric='rbf', gamma=1.0/sigma2, n_jobs=-1)
    return K