Dulce France
Eugen Weber
Cancer is associated with early changes in the cardiovascular system (CV) before overt cardiotoxicity. Endothelial dysfunction induced by chemotherapeutic regimens but there no data for endothelial glycocalyx cancer.Sixty-four patients cancer (65.6% solid tumors and 34.4% hematological malignancies) 32 controls from outpatient cardiology clinic were included study. The perfused boundary region (PBR) of sublingual arterial microvessels, Pulse Wave Velocity (PWV) augmentation index (AI) measured. A standard transthoracic echocardiogram plus assessment global longitudinal strain (GLS) all cardiac chambers performed.There was difference baseline profile (age, sex, smoking, hypertension, diabetes, hyperlipidemia coronary artery disease) echocardiographic parameters between two groups, exception left atrial volume (33.3 ± 13 vs 27.6 6.5 ml/m2 controls). PBR 5–25 20–25 significantly increased (2.11 0.36 1.97 0.21 μm, p = 0.025 2.65 0.48 2.40 0.012, respectively). thickness impairment independent traditional CV risk factors anticancer therapy, proportional to disease stage (r 0.337, 0.044). However, stiffness groups (PWV 10.74 4.11 11.26 3.38 m/s, 0.539 AI 11.28 28.87 15.38 18.8 %, 0.470).Endothelial function as assessed impaired without This implies that might be useful microvascular toxicity cancer.
Journal of Historical Geography