The Genetic History of France
Aude Saint Pierre|Joanna Giemza|Mathilde Karakachoff|Isabel Alves|Philippe Amouyel|Jean‐François Dartigues|Christophe Tzourio|Martial Monteil|Pilar Galán|Serge Herçberg|Richard Redon|Emmanuelle Génin|Christian Dina
ABSTRACT The study of the genetic structure different countries within Europe has provided significant insights into their demographic history and actual stratification. Although France occupies a particular location at end European peninsula crossroads migration routes, few population studies have been conducted so far with genome-wide data. In this study, we analyzed SNP-chip data from 2 184 individuals born in who were enrolled two independent cohorts. Using FineStructure, six clusters found that very consistent between These match extremely well geography overlap historical linguistic divisions France. By modeling relationship genetics using EEMS software, able to detect gene flow barriers are similar cohorts corresponds major French rivers or mountains. Estimations effective sizes IBDNe program also revealed patterns both rapid increase over last 150 generations what was observed other countries. A marked bottleneck is consistently seen datasets starting fourteenth century when Black Death raged Europe. conclusion, by performing first exhaustive France, fill gap would be useful medical geneticists but historians archeologists.
bioRxiv (Cold Spring Harbor Laboratory)