Petra Hoffknecht Amanda Tufman Thomas Wehler Theo Pelzer Rainer Wiewrodt Martin Schütz Monika Serke Jan Stöhlmacher-Williams Angela Märten Rudolf Maria Huber Nicolas J Dickgreber Afatinib Compassionate Use Consortium (ACUC) A Abdollahi A Ammon S P Aries C Arntzen H J Achenbach D Atanackovic A Atmaca N Basara D Binder B Borchard M Bos W Brugger S Budweiser K Conrad K Corduan D Cortes- Incio B Dallmeier C Denzlinger H G Derigs N Dickgreber I Dittrich T Düll W Engel-Riedel M Faehling A Fertl J R Fischer D Fleckenstein G Folprecht A Forstbauer Y France N Frickhofen S Frühauf M Gardizi T Gauler C Gessner W Gleiber E Gökkurt M Görner C Grah J Greeve J Greiner F Griesinger C Grohé W Grüning D Guggenberger S Gütz C Hannig D Heigener M Heilmann B Heinrich G Hense M Hoiczyk R M Huber G Illerhaus G Jacobs P Jung K O Kambartel L Kayikci J Kern J Kersten M Kiehl M Kimmich J Kisro H Knipp Y D Ko J U Koch C H Koehne J Kollmeier A Kommer W Körber K Kratz-Albers G Krause R Krügel E Laack R Leistner U Liebers M Lommatzsch C Maintz C Mozek A Matzdorff M Mohr W Neumeister H Nolte T Overbeck M Östreicher J Panse T Pelzer K Peters M Planker A Reissig M Ritter A Rittmeyer S Rösel P Sadjadian B Sandritter M Schatz M Scheffler G Schmid-Bindert A Schmittel C P Schneider W Schneider-Kappus F Schneller E Schorb J Schreiber F Schüler M Schuler A Schulz-Abelius C Schumann W Schütte S Schütz M Schütz M Sebastian M Serke D Spissinger W Spengler H Staiger U Steffen I Stehle H Steiniger K Stengele S Steppert J Stöhlmacher-Williams T Strapatsas B Sulzbach A Tessmer M Thomas B Thöming D Ukena B Wagner T Wagner D Wagner-Hug H Wahn T Wehler R Wiewrodt C Witt M Wohlleber J Wolf M Wolf K Wricke O Zaba I Zander
10.1097/JTO.0000000000000380
J Thorac Oncol
2015 Jan;10(1):156-63.
NO-CC CODE
https://pubmed.ncbi.nlm.nih.gov/25247337/
Brain Neoplasms / drug therapy Carcinoma, Non-Small-Cell Lung / drug therapy Lung Neoplasms / drug therapy Meningeal Neoplasms / drug therapy Protein Kinase Inhibitors / therapeutic use Quinazolines / therapeutic use
Brain Neoplasms / drug therapy Carcinoma, Non-Small-Cell Lung / drug therapy Lung Neoplasms / drug therapy Meningeal Neoplasms / drug therapy Protein Kinase Inhibitors / therapeutic use Quinazolines / therapeutic use Case Reports Research Support, Non-U.S. Gov't Adult Afatinib Aged Brain Neoplasms / secondary Carcinoma, Non-Small-Cell Lung / enzymology Carcinoma, Non-Small-Cell Lung / pathology Disease Progression ErbB Receptors / antagonists & inhibitors ErbB Receptors / genetics Female Humans Lung Neoplasms / enzymology Lung Neoplasms / pathology Male Meningeal Neoplasms / secondary Middle Aged Mutation Treatment Outcome Protein Kinase Inhibitors Quinazolines Afatinib EGFR protein, human ErbB Receptors
PMC4276567
25247337
Efficacy of the irreversible ErbB family blocker afatinib in epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-pretreated non-small-cell lung cancer patients with brain metastases or leptomeningeal disease
2015