Virginia Meda Spaccamela Rocio G Valencia Oleksandr Pastukhov Andrea Duppenthaler Matthias S Dettmer Juliane Erb Urs C Steiner Sven Hillinger Carsten Speckmann Stephan Ehl Janine Reichenbach Ulrich Siler
10.3389/fimmu.2019.02236
Front Immunol
2019 Oct 18;10:2236.
il-18/ifn-γ loop chronic granulomatous disease hyperinflammation macrophage priming macrophage re-priming
CC BY
https://pubmed.ncbi.nlm.nih.gov/31681257/
Granulomatous Disease, Chronic / immunology Interferon-gamma / immunology Interleukin-18 / immunology Macrophages / immunology Paracrine Communication / immunology Signal Transduction / immunology
Granulomatous Disease, Chronic / immunology Interferon-gamma / immunology Interleukin-18 / immunology Macrophages / immunology Paracrine Communication / immunology Signal Transduction / immunology Case Reports Clinical Trial Research Support, Non-U.S. Gov't Adolescent Adult Child Female Granulomatous Disease, Chronic / genetics Granulomatous Disease, Chronic / pathology Humans Infant Inflammation / genetics Inflammation / immunology Inflammation / pathology Interferon-gamma / genetics Interleukin-18 / genetics Macrophages / pathology Male Paracrine Communication / genetics Signal Transduction / genetics IFNG protein, human IL18 protein, human Interleukin-18 Interferon-gamma
PMC6813411
31681257
High Levels of IL-18 and IFN-γ in Chronically Inflamed Tissue in Chronic Granulomatous Disease
2019