Takeo Shibata Sumit Shah Teresa Evans Hannah Coleman Benjamin J Lieblong Horace J Spencer Charles M Quick Toshiyuki Sasagawa Owen W Stephens Erich Peterson Donald Johann Jr Yong-Chen Lu Mayumi Nakagawa
10.3389/fimmu.2021.645299
Front Immunol
2021 Sep 30;12:645299.
t cell receptor cervical intraepithelial neoplasia clonal expansion human papillomavirus therapeutic vaccine
CC BY
https://pubmed.ncbi.nlm.nih.gov/34659195/
Cancer Vaccines / therapeutic use Human papillomavirus 16 / immunology Lymphocytes, Tumor-Infiltrating / drug effects Papillomavirus Vaccines / therapeutic use Squamous Intraepithelial Lesions / drug therapy T-Lymphocytes / drug effects Uterine Cervical Neoplasms / drug therapy
Cancer Vaccines / therapeutic use Human papillomavirus 16 / immunology Lymphocytes, Tumor-Infiltrating / drug effects Papillomavirus Vaccines / therapeutic use Squamous Intraepithelial Lesions / drug therapy T-Lymphocytes / drug effects Uterine Cervical Neoplasms / drug therapy Case Reports Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Adult Cell Proliferation / drug effects Cells, Cultured Clinical Trials, Phase I as Topic Female Genes, T-Cell Receptor High-Throughput Nucleotide Sequencing Host-Pathogen Interactions Humans Lymphocyte Activation / drug effects Lymphocytes, Tumor-Infiltrating / immunology Lymphocytes, Tumor-Infiltrating / virology Neoplasm Grading RNA-Seq Remission Induction Squamous Intraepithelial Lesions / immunology Squamous Intraepithelial Lesions / pathology Squamous Intraepithelial Lesions / virology T-Lymphocytes / immunology T-Lymphocytes / virology Time Factors Treatment Outcome Uterine Cervical Neoplasms / immunology Uterine Cervical Neoplasms / pathology Uterine Cervical Neoplasms / virology Cancer Vaccines Papillomavirus Vaccines
PMC8515132
34659195
Expansion of Human Papillomavirus-Specific T Cells in Periphery and Cervix in a Therapeutic Vaccine Recipient Whose Cervical High-Grade Squamous Intraepithelial Lesion Regressed
2021