Frank Hoentjen Stephen B Hanauer Nanne K de Boer David T Rubin
10.1007/s10620-011-1999-x
Dig Dis Sci
2012 Jan;57(1):250-3.
CC BY-NC
https://pubmed.ncbi.nlm.nih.gov/22147254/
Allopurinol / therapeutic use Colitis, Ulcerative / drug therapy Colitis, Ulcerative / metabolism Guanine Nucleotides / metabolism Mercaptopurine / analogs & derivatives Mercaptopurine / therapeutic use Thionucleotides / metabolism
Allopurinol / therapeutic use Colitis, Ulcerative / drug therapy Colitis, Ulcerative / metabolism Guanine Nucleotides / metabolism Mercaptopurine / analogs & derivatives Mercaptopurine / therapeutic use Thionucleotides / metabolism Case Reports Antimetabolites / therapeutic use Colitis, Ulcerative / genetics Dose-Response Relationship, Drug Drug Therapy, Combination Humans Liver / enzymology Male Mercaptopurine / metabolism Methyltransferases / metabolism Steroids / therapeutic use Treatment Outcome Young Adult Antimetabolites Guanine Nucleotides Steroids Thionucleotides 6-thioguanylic acid Allopurinol 6-methylthiopurine Mercaptopurine Methyltransferases thiopurine methyltransferase
PMC3253335
22147254
Two brothers with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction
2012