Jun Li Bing Wei Junnan Feng Xinxin Wu Yuxi Chang Yi Wang Xiuli Yang Haiyan Zhang Sile Han Cuiyun Zhang Jiawen Zheng Harry J M Groen Anke van den Berg Jie Ma Hongle Li Yongjun Guo
10.3389/fendo.2022.1006480
Front Endocrinol (Lausanne)
2022 Dec 13;13:1006480.
myc amplification tp53 and rb1 loss lung adenocarcinoma osimertinib small cell lung cancer transformation
CC BY
https://pubmed.ncbi.nlm.nih.gov/36583000/
Adenocarcinoma of Lung / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Small Cell Lung Carcinoma / genetics
Adenocarcinoma of Lung / genetics Lung Neoplasms / drug therapy Lung Neoplasms / genetics Lung Neoplasms / pathology Small Cell Lung Carcinoma / genetics Case Reports Research Support, Non-U.S. Gov't ErbB Receptors / genetics Female Humans In Situ Hybridization, Fluorescence Phosphatidylinositol 3-Kinases / genetics Retinoblastoma Binding Proteins / genetics Retrospective Studies Tumor Suppressor Protein p53 / genetics Ubiquitin-Protein Ligases / genetics Tumor Suppressor Protein p53 Phosphatidylinositol 3-Kinases ErbB Receptors TP53 protein, human RB1 protein, human Ubiquitin-Protein Ligases Retinoblastoma Binding Proteins
PMC9792468
36583000
Case report: TP53 and RB1 loss may facilitate the transformation from lung adenocarcinoma to small cell lung cancer by expressing neuroendocrine markers
2022