Andrei E Medvedev Arnd Lentschat Douglas B Kuhns Jorge C G Blanco Cindy Salkowski Shuling Zhang Moshe Arditi John I Gallin Stefanie N Vogel
10.1084/jem.20030701
J Exp Med
2003 Aug 18;198(4):521-31.
CC BY-NC-SA
https://pubmed.ncbi.nlm.nih.gov/12925671/
Bacterial Infections / metabolism Interleukin-1 / immunology Lipopolysaccharides / immunology Phosphotransferases (Alcohol Group Acceptor) / genetics Phosphotransferases (Alcohol Group Acceptor) / metabolism Point Mutation
Bacterial Infections / metabolism Interleukin-1 / immunology Lipopolysaccharides / immunology Phosphotransferases (Alcohol Group Acceptor) / genetics Phosphotransferases (Alcohol Group Acceptor) / metabolism Point Mutation Case Reports Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Adult Bacterial Infections / immunology Cell Line Female Humans Inflammation / immunology Inflammation / metabolism Interleukin-1 / metabolism Interleukin-1 Receptor-Associated Kinases Interleukin-18 / immunology Interleukin-18 / metabolism Leukocytes, Mononuclear / metabolism Lipopolysaccharides / metabolism Molecular Sequence Data NF-kappa B / metabolism Neutrophils / immunology Neutrophils / metabolism Signal Transduction / physiology Transcription Factor AP-1 / metabolism Interleukin-1 Interleukin-18 Lipopolysaccharides NF-kappa B Transcription Factor AP-1 Phosphotransferases (Alcohol Group Acceptor) Interleukin-1 Receptor-Associated Kinases
PMC2194174
12925671
Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections
2003