Rika Moriya Satoshi Hokari Satoshi Shibata Takeshi Koizumi Takafumi Tetsuka Kazuhiko Ito Hideki Hashidate Hiroki Tsukada
10.2169/internalmedicine.56.7452
Intern Med
2017;56(15):2013-2017.
adenocarcinoma epidermal growth factor receptor tyrosine kinase inhibitor histological transformation large-cell neuroendocrine carcinoma
CC BY-NC-ND
https://pubmed.ncbi.nlm.nih.gov/28768973/
Carcinoma, Large Cell / genetics Carcinoma, Neuroendocrine / genetics ErbB Receptors / genetics Lung Neoplasms / genetics Neoplasms, Multiple Primary / genetics
Carcinoma, Large Cell / genetics Carcinoma, Neuroendocrine / genetics ErbB Receptors / genetics Lung Neoplasms / genetics Neoplasms, Multiple Primary / genetics Case Reports Adenocarcinoma / genetics Adenocarcinoma / pathology Adenocarcinoma of Lung Autopsy Carcinoma, Large Cell / drug therapy Carcinoma, Large Cell / pathology Carcinoma, Neuroendocrine / drug therapy Carcinoma, Neuroendocrine / pathology Drug Resistance, Neoplasm / genetics Fatal Outcome Female Humans Lung Neoplasms / drug therapy Lung Neoplasms / pathology Middle Aged Neoplasm Recurrence, Local / drug therapy Neoplasm Recurrence, Local / genetics Neoplasm Recurrence, Local / pathology Neoplasms, Multiple Primary / drug therapy Neoplasms, Multiple Primary / pathology Protein Kinase Inhibitors / therapeutic use Sequence Deletion Protein Kinase Inhibitors EGFR protein, human ErbB Receptors
PMC5577079
28768973
Histological Transformation to Large Cell Neuroendocrine Carcinoma from Lung Adenocarcinoma Harboring an EGFR Mutation: An Autopsy Case Report
2017