Andrew J Wagner Izabela Malinowska-Kolodziej Jeffrey A Morgan Wei Qin Christopher D M Fletcher Natalie Vena Azra H Ligon Cristina R Antonescu Nikhil H Ramaiya George D Demetri David J Kwiatkowski Robert G Maki
10.1200/JCO.2009.25.2981
J Clin Oncol
2010 Feb 10;28(5):835-40.
author_manuscript
https://pubmed.ncbi.nlm.nih.gov/20048174/
Antibiotics, Antineoplastic / therapeutic use Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Perivascular Epithelioid Cell Neoplasms / drug therapy Protein Serine-Threonine Kinases / antagonists & inhibitors Sirolimus / therapeutic use Transcription Factors / antagonists & inhibitors
Antibiotics, Antineoplastic / therapeutic use Intracellular Signaling Peptides and Proteins / antagonists & inhibitors Perivascular Epithelioid Cell Neoplasms / drug therapy Protein Serine-Threonine Kinases / antagonists & inhibitors Sirolimus / therapeutic use Transcription Factors / antagonists & inhibitors Case Reports Multicenter Study Research Support, Non-U.S. Gov't Administration, Oral Aged Antibiotics, Antineoplastic / administration & dosage Antibiotics, Antineoplastic / adverse effects Female Humans Immunohistochemistry In Situ Hybridization, Fluorescence Intracellular Signaling Peptides and Proteins / analysis Male Mechanistic Target of Rapamycin Complex 1 Middle Aged Multiprotein Complexes Perivascular Epithelioid Cell Neoplasms / chemistry Perivascular Epithelioid Cell Neoplasms / diagnostic imaging Perivascular Epithelioid Cell Neoplasms / genetics Perivascular Epithelioid Cell Neoplasms / secondary Protein Serine-Threonine Kinases / analysis Proteins Sirolimus / administration & dosage Sirolimus / adverse effects TOR Serine-Threonine Kinases Time Factors Tomography, X-Ray Computed Transcription Factors / analysis Treatment Outcome Tuberous Sclerosis Complex 1 Protein Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins / analysis Tumor Suppressor Proteins / genetics United States Antibiotics, Antineoplastic Intracellular Signaling Peptides and Proteins Multiprotein Complexes Proteins TSC1 protein, human TSC2 protein, human Transcription Factors Tuberous Sclerosis Complex 1 Protein Tuberous Sclerosis Complex 2 Protein Tumor Suppressor Proteins MTOR protein, human Mechanistic Target of Rapamycin Complex 1 Protein Serine-Threonine Kinases TOR Serine-Threonine Kinases Sirolimus
PMC4810029
20048174
Clinical activity of mTOR inhibition with sirolimus in malignant perivascular epithelioid cell tumors: targeting the pathogenic activation of mTORC1 in tumors
2010