F J T Staal R B van der Luijt M R M Baert J van Drunen H van Bakel E Peters I de Valk H K P van Amstel M J B Taphoorn G H Jansen C W M van Veelen B Burgering G E J Staal
10.1038/sj.bjc.6600206
Br J Cancer
2002 May 20;86(10):1586-91.
CC BY
https://pubmed.ncbi.nlm.nih.gov/12085208/
Amino Acid Substitution Brain Neoplasms / genetics Frontal Lobe / pathology Germ-Line Mutation Meningeal Neoplasms / genetics Meningioma / genetics Mutation, Missense Neoplasm Proteins / genetics Neoplasms, Multiple Primary / genetics Oligodendroglioma / genetics Phosphoric Monoester Hydrolases / genetics Point Mutation Protein Serine-Threonine Kinases Tumor Suppressor Proteins / genetics
Amino Acid Substitution Brain Neoplasms / genetics Frontal Lobe / pathology Germ-Line Mutation Meningeal Neoplasms / genetics Meningioma / genetics Mutation, Missense Neoplasm Proteins / genetics Neoplasms, Multiple Primary / genetics Oligodendroglioma / genetics Phosphoric Monoester Hydrolases / genetics Point Mutation Protein Serine-Threonine Kinases Tumor Suppressor Proteins / genetics Case Reports Research Support, Non-U.S. Gov't Adult Apoptosis / genetics Brain Neoplasms / pathology Cell Division Cell Lineage DNA Mutational Analysis DNA, Neoplasm / genetics Enzyme Activation / drug effects Genetic Predisposition to Disease Humans Insulin / pharmacology Loss of Heterozygosity Male Meningeal Neoplasms / pathology Meningioma / pathology Models, Molecular Neoplasm Proteins / chemistry Neoplasm Proteins / physiology Neoplasms, Multiple Primary / pathology Oligodendroglioma / pathology PTEN Phosphohydrolase Phosphoric Monoester Hydrolases / chemistry Phosphoric Monoester Hydrolases / physiology Protein Conformation Proto-Oncogene Proteins / metabolism Proto-Oncogene Proteins c-akt Transfection Tumor Suppressor Proteins / chemistry Tumor Suppressor Proteins / physiology U937 Cells / drug effects U937 Cells / enzymology DNA, Neoplasm Insulin Neoplasm Proteins Proto-Oncogene Proteins Tumor Suppressor Proteins AKT1 protein, human Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-akt Phosphoric Monoester Hydrolases PTEN Phosphohydrolase PTEN protein, human
PMC2746590
12085208
A novel germline mutation of PTEN associated with brain tumours of multiple lineages
2002