M Wasif Saif Adam M Lee Steven M Offer Kathleen McConnell Valerie Relias Robert B Diasio
10.1016/j.mayocp.2013.09.008
Mayo Clin Proc
2014 Jan;89(1):131-136.
5-fu 5-fluorouracil 5-fluorouracil, leucovorin, oxaliplatin dpd folfox inr pcr base pair bp dihydropyrimidine dehydrogenase international normalized ratio polymerase chain reaction
author_manuscript
https://pubmed.ncbi.nlm.nih.gov/24388031/
Adenocarcinoma / drug therapy Antineoplastic Combined Chemotherapy Protocols / adverse effects Antineoplastic Combined Chemotherapy Protocols / therapeutic use Black or African American / genetics Colonic Neoplasms / drug therapy Dihydrouracil Dehydrogenase (NADP) / genetics Genetic Markers
Adenocarcinoma / drug therapy Antineoplastic Combined Chemotherapy Protocols / adverse effects Antineoplastic Combined Chemotherapy Protocols / therapeutic use Black or African American / genetics Colonic Neoplasms / drug therapy Dihydrouracil Dehydrogenase (NADP) / genetics Genetic Markers Case Reports Research Support, N.I.H., Extramural Adenocarcinoma / enzymology Adenocarcinoma / pathology Adenocarcinoma / secondary Colonic Neoplasms / enzymology Colonic Neoplasms / pathology Diarrhea / chemically induced Dihydrouracil Dehydrogenase (NADP) / drug effects Fatal Outcome Female Fluorouracil / administration & dosage Fluorouracil / adverse effects Fluorouracil / therapeutic use Heat-Shock Proteins Humans Leucovorin / adverse effects Leucovorin / therapeutic use Middle Aged Mucositis / chemically induced Neoplasm Staging Organoplatinum Compounds / adverse effects Organoplatinum Compounds / therapeutic use Peptide Fragments Polymorphism, Genetic Precision Medicine Stomatitis / chemically induced Genetic Markers Heat-Shock Proteins Organoplatinum Compounds Peptide Fragments SNP nonapeptide Dihydrouracil Dehydrogenase (NADP) Leucovorin Fluorouracil Folfox protocol
PMC4071869
24388031
A DPYD variant (Y186C) specific to individuals of African descent in a patient with life-threatening 5-FU toxic effects: potential for an individualized medicine approach
2014